Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	isArtifactMode	oxoGCut	pox	pox_cutoff	qox	t_alt_count	t_ref_count	validation_alt_allele	validation_tumor_sample							
CAMTA1	23261	broad.mit.edu	37	1	7723702	7723702	+	Silent	SNP	G	G	A			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr1:7723702G>A	uc001aoi.2	+	9	1302	c.1095G>A	c.(1093-1095)GGG>GGA	p.G365G		NM_015215	NP_056030	Q9Y6Y1	CMTA1_HUMAN	calmodulin-binding transcription activator 1	365					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	calmodulin binding			ovary(5)|central_nervous_system(2)|breast(1)|pancreas(1)	9	Ovarian(185;0.0634)	all_epithelial(116;8.38e-23)|all_lung(118;5.87e-07)|Lung NSC(185;3.43e-06)|Renal(390;0.000219)|Breast(487;0.000307)|Colorectal(325;0.000615)|Hepatocellular(190;0.0088)|Myeloproliferative disorder(586;0.0303)|Ovarian(437;0.0388)		UCEC - Uterine corpus endometrioid carcinoma (279;0.101)|Colorectal(212;1.33e-05)|COAD - Colon adenocarcinoma(227;0.000235)|BRCA - Breast invasive adenocarcinoma(304;0.000864)|Kidney(185;0.00244)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0179)|READ - Rectum adenocarcinoma(331;0.133)		TCAGCAGCGGGCTCAACAGCG	0.662		NaN											0	0	0	0.010729	0	12	126									
PER3	8863	broad.mit.edu	37	1	7863866	7863866	+	Missense_Mutation	SNP	G	G	T			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr1:7863866G>T	uc001aoo.2	+	9	1266	c.1091G>T	c.(1090-1092)AGC>ATC	p.S364I	PER3_uc009vmg.1_Missense_Mutation_p.S365I|PER3_uc009vmh.1_Missense_Mutation_p.S365I|PER3_uc001aop.2_Missense_Mutation_p.S365I|PER3_uc010nzw.1_Missense_Mutation_p.S46I|PER3_uc001aon.2_Missense_Mutation_p.S364I	NM_016831	NP_058515	P56645	PER3_HUMAN	period 3	364	PAC.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	signal transducer activity			ovary(1)|pancreas(1)|skin(1)	3	Ovarian(185;0.0634)|all_lung(157;0.178)	all_epithelial(116;9.35e-21)|all_lung(118;7.57e-07)|Lung NSC(185;4.52e-06)|Renal(390;0.000147)|Breast(487;0.00086)|Colorectal(325;0.000959)|Hepatocellular(190;0.00825)|Ovarian(437;0.0253)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0234)|all cancers(8;8.58e-70)|GBM - Glioblastoma multiforme(8;1.81e-35)|Colorectal(212;2.06e-07)|COAD - Colon adenocarcinoma(227;1.92e-05)|Kidney(185;7.18e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000472)|STAD - Stomach adenocarcinoma(132;0.00118)|KIRC - Kidney renal clear cell carcinoma(229;0.00122)|READ - Rectum adenocarcinoma(331;0.0649)		AATCCCTGGAGCCGGAAGATT	0.403		NaN											1	0	1.36161e-19	0.004289	1.53322e-19	36	41									
RERE	473	broad.mit.edu	37	1	8617577	8617577	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr1:8617577C>G	uc001ape.2	-	6	1338	c.528G>C	c.(526-528)AAG>AAC	p.K176N	RERE_uc001apf.2_Missense_Mutation_p.K176N|RERE_uc001aph.1_Missense_Mutation_p.K176N	NM_012102	NP_036234	Q9P2R6	RERE_HUMAN	atrophin-1 like protein isoform a	176	BAH.				multicellular organismal development|NLS-bearing substrate import into nucleus	mitochondrion	poly-glutamine tract binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2	Ovarian(185;0.0661)	all_epithelial(116;1.17e-21)|all_lung(118;1.4e-06)|Lung NSC(185;3.06e-06)|Renal(390;0.000147)|Breast(348;0.000206)|Colorectal(325;0.00187)|Hepatocellular(190;0.00825)|Ovarian(437;0.0253)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;9.64e-67)|GBM - Glioblastoma multiforme(8;9.89e-33)|Colorectal(212;1.45e-07)|COAD - Colon adenocarcinoma(227;3.42e-05)|Kidney(185;6e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000533)|KIRC - Kidney renal clear cell carcinoma(229;0.00106)|STAD - Stomach adenocarcinoma(132;0.00118)|READ - Rectum adenocarcinoma(331;0.0419)|Lung(427;0.195)		GATGGTCCCTCTTACTCTGAA	0.438		NaN											0	0	0	0.012319	0	22	30									
DFFA	1676	broad.mit.edu	37	1	10523593	10523593	+	Missense_Mutation	SNP	G	G	T			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr1:10523593G>T	uc001arj.2	-	4	624	c.526C>A	c.(526-528)CAA>AAA	p.Q176K	DFFA_uc001ark.2_Missense_Mutation_p.Q176K	NM_004401	NP_004392	O00273	DFFA_HUMAN	DNA fragmentation factor, 45kDa, alpha	176					DNA fragmentation involved in apoptotic nuclear change|intracellular signal transduction|negative regulation of apoptosis	cytosol|mitochondrion|nucleoplasm|plasma membrane	deoxyribonuclease activity|identical protein binding				0	Ovarian(185;0.203)	all_lung(284;1.31e-05)|Lung NSC(185;2.19e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.25e-07)|COAD - Colon adenocarcinoma(227;7.25e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000296)|Kidney(185;0.00074)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(132;0.0167)|READ - Rectum adenocarcinoma(331;0.0487)		AGCACCTGTTGGAGTGTGTGC	0.547		NaN											1	0	3.61848e-18	0.007835	4.05776e-18	40	167									
C1orf127	148345	broad.mit.edu	37	1	11017751	11017751	+	Silent	SNP	C	C	T			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr1:11017751C>T	uc010oao.1	-	3	173	c.168G>A	c.(166-168)CTG>CTA	p.L56L	C1orf127_uc001arr.1_Silent_p.L56L|C1orf127_uc001ars.1_Silent_p.L56L	NM_173507	NP_775778	B7ZLG7	B7ZLG7_HUMAN	hypothetical protein LOC148345	56										ovary(1)	1	Ovarian(185;0.249)	Lung NSC(185;0.000226)|all_lung(284;0.000302)|Renal(390;0.000469)|Colorectal(325;0.0062)|Breast(348;0.0139)|Hepatocellular(190;0.0305)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0731)	STAD - Stomach adenocarcinoma(5;0.0224)	UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.71e-07)|COAD - Colon adenocarcinoma(227;7.79e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000305)|Kidney(185;0.000785)|KIRC - Kidney renal clear cell carcinoma(229;0.00262)|READ - Rectum adenocarcinoma(331;0.0509)		ACAGTCCCATCAGGCTGGCGT	0.582		NaN											0	0	0	0.00361	0	62	83									
SPEN	23013	broad.mit.edu	37	1	16203049	16203049	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr1:16203049C>G	uc001axk.1	+	3	961	c.757C>G	c.(757-759)CAG>GAG	p.Q253E	SPEN_uc010obp.1_Missense_Mutation_p.Q212E	NM_015001	NP_055816	Q96T58	MINT_HUMAN	spen homolog, transcriptional regulator	253	Ser-rich.|Arg-rich.|By similarity.				interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|Notch signaling pathway	nucleus	nucleotide binding|protein binding|RNA binding			ovary(6)|breast(3)|lung(2)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	15		Colorectal(325;0.000258)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0185)|Colorectal(212;5.96e-07)|COAD - Colon adenocarcinoma(227;3.11e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000115)|Kidney(64;0.000212)|KIRC - Kidney renal clear cell carcinoma(64;0.003)|STAD - Stomach adenocarcinoma(313;0.013)|READ - Rectum adenocarcinoma(331;0.0681)		GTCTAGAAATCAGTCTCCTCA	0.537		NaN											0	0	0	0.005524	0	33	90									
LUZP1	7798	broad.mit.edu	37	1	23419953	23419953	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr1:23419953C>T	uc001bgk.2	-	4	1186	c.802G>A	c.(802-804)GAG>AAG	p.E268K	LUZP1_uc010odv.1_Missense_Mutation_p.E268K|LUZP1_uc001bgl.2_Missense_Mutation_p.E268K|LUZP1_uc001bgm.1_Missense_Mutation_p.E268K	NM_033631	NP_361013	Q86V48	LUZP1_HUMAN	leucine zipper protein 1	268	Potential.					nucleus					0		Colorectal(325;3.46e-05)|Lung NSC(340;4.15e-05)|all_lung(284;6.64e-05)|Renal(390;0.000219)|Ovarian(437;0.00373)|Breast(348;0.00815)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;4.88e-27)|Colorectal(126;8.36e-08)|COAD - Colon adenocarcinoma(152;4.31e-06)|GBM - Glioblastoma multiforme(114;8.64e-05)|BRCA - Breast invasive adenocarcinoma(304;0.00112)|KIRC - Kidney renal clear cell carcinoma(1967;0.00176)|STAD - Stomach adenocarcinoma(196;0.0146)|READ - Rectum adenocarcinoma(331;0.0686)|Lung(427;0.0967)|LUSC - Lung squamous cell carcinoma(448;0.199)		GTTTCATTCTCTACCTGCTTT	0.413		NaN											0	0	0	0.010818	0	32	51									
LUZP1	7798	broad.mit.edu	37	1	23420139	23420139	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr1:23420139C>G	uc001bgk.2	-	4	1000	c.616G>C	c.(616-618)GAA>CAA	p.E206Q	LUZP1_uc010odv.1_Missense_Mutation_p.E206Q|LUZP1_uc001bgl.2_Missense_Mutation_p.E206Q|LUZP1_uc001bgm.1_Missense_Mutation_p.E206Q	NM_033631	NP_361013	Q86V48	LUZP1_HUMAN	leucine zipper protein 1	206	Potential.					nucleus					0		Colorectal(325;3.46e-05)|Lung NSC(340;4.15e-05)|all_lung(284;6.64e-05)|Renal(390;0.000219)|Ovarian(437;0.00373)|Breast(348;0.00815)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;4.88e-27)|Colorectal(126;8.36e-08)|COAD - Colon adenocarcinoma(152;4.31e-06)|GBM - Glioblastoma multiforme(114;8.64e-05)|BRCA - Breast invasive adenocarcinoma(304;0.00112)|KIRC - Kidney renal clear cell carcinoma(1967;0.00176)|STAD - Stomach adenocarcinoma(196;0.0146)|READ - Rectum adenocarcinoma(331;0.0686)|Lung(427;0.0967)|LUSC - Lung squamous cell carcinoma(448;0.199)		TTCTCATTTTCTTTCTCCTTT	0.328		NaN											0	0	0	0.007413	0	20	29									
ASAP3	55616	broad.mit.edu	37	1	23763091	23763091	+	Silent	SNP	G	G	A			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr1:23763091G>A	uc001bha.2	-	16	1657	c.1533C>T	c.(1531-1533)CCC>CCT	p.P511P	ASAP3_uc001bgy.1_Silent_p.P15P|ASAP3_uc001bgz.1_RNA|ASAP3_uc010odz.1_Silent_p.P380P|ASAP3_uc010oea.1_Silent_p.P502P|ASAP3_uc001bhb.2_Silent_p.P34P	NM_017707	NP_060177	Q8TDY4	ASAP3_HUMAN	ArfGAP with SH3 domain, ankyrin repeat and PH	511	Arf-GAP.				regulation of ARF GTPase activity	cytoplasm	ARF GTPase activator activity|zinc ion binding			large_intestine(1)|ovary(1)|skin(1)	3						CGCCGTGTGAGGGTAGCTGGG	0.587		NaN											0	0	0	0.00361	0	56	70									
ZNF683	257101	broad.mit.edu	37	1	26691249	26691249	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr1:26691249G>A	uc001bmg.1	-	4	906	c.788C>T	c.(787-789)TCT>TTT	p.S263F	ZNF683_uc001bmh.1_Missense_Mutation_p.S263F|ZNF683_uc009vsj.1_Missense_Mutation_p.S263F	NM_173574	NP_775845	Q8IZ20	ZN683_HUMAN	zinc finger protein 683	263					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_cancers(24;2.39e-25)|Colorectal(325;3.46e-05)|all_lung(284;5.94e-05)|Lung NSC(340;7.26e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.00637)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;1.76e-26)|Colorectal(126;1.38e-08)|COAD - Colon adenocarcinoma(152;9.31e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.000751)|BRCA - Breast invasive adenocarcinoma(304;0.00099)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.00793)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.159)|LUSC - Lung squamous cell carcinoma(448;0.233)		AGCTTGGCCAGAGGCTTGGAA	0.642		NaN											0	0	0	0.00361	0	58	48									
FCN3	8547	broad.mit.edu	37	1	27699711	27699711	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr1:27699711C>G	uc001boa.2	-	5	315	c.309G>C	c.(307-309)TTG>TTC	p.L103F	FCN3_uc001bob.2_Missense_Mutation_p.L92F	NM_003665	NP_003656	O75636	FCN3_HUMAN	ficolin 3 isoform 1 precursor	103	Fibrinogen C-terminal.				complement activation, lectin pathway|signal transduction	collagen|extracellular space	receptor binding|sugar binding				0		all_lung(284;1.6e-05)|Lung NSC(340;2.92e-05)|Colorectal(325;3.46e-05)|Renal(390;0.0007)|Breast(348;0.0021)|Ovarian(437;0.0175)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0415)|OV - Ovarian serous cystadenocarcinoma(117;1.42e-27)|Colorectal(126;1.24e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00128)|KIRC - Kidney renal clear cell carcinoma(1967;0.00155)|STAD - Stomach adenocarcinoma(196;0.00303)|READ - Rectum adenocarcinoma(331;0.0419)		ACCAGCCGCTCAAGGTGGCGC	0.642		NaN											0	0	0	0.003271	0	34	71									
GMEB1	10691	broad.mit.edu	37	1	29040947	29040947	+	Missense_Mutation	SNP	A	A	C			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr1:29040947A>C	uc001bra.2	+	10	1522	c.1384A>C	c.(1384-1386)ACA>CCA	p.T462P	GMEB1_uc001bqz.2_Missense_Mutation_p.T452P|GMEB1_uc001brb.2_Missense_Mutation_p.T452P	NM_006582	NP_006573	Q9Y692	GMEB1_HUMAN	glucocorticoid modulatory element binding	462					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|metal ion binding|transcription coactivator activity				0		Colorectal(325;3.46e-05)|Lung NSC(340;0.000451)|all_lung(284;0.00063)|Breast(348;0.00502)|Renal(390;0.00555)|all_neural(195;0.0227)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0563)|Medulloblastoma(700;0.123)		Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|STAD - Stomach adenocarcinoma(196;0.00299)|BRCA - Breast invasive adenocarcinoma(304;0.0221)|KIRC - Kidney renal clear cell carcinoma(1967;0.0296)|READ - Rectum adenocarcinoma(331;0.0649)		CTCACCAGACACAGTGACCAT	0.582		NaN											0	0	0	0.003954	0	26	83									
S100PBP	64766	broad.mit.edu	37	1	33321593	33321593	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr1:33321593G>A	uc001bvz.2	+	7	1458	c.1181G>A	c.(1180-1182)CGA>CAA	p.R394Q	S100PBP_uc001bwc.2_Missense_Mutation_p.R394Q|S100PBP_uc001bwd.2_RNA	NM_022753	NP_073590	Q96BU1	S1PBP_HUMAN	S100P binding protein isoform a	394						nucleus	calcium-dependent protein binding				0		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Breast(348;0.244)				AGGAACATGCGAAGCCACCAT	0.512		NaN											0	0	0	0.003954	0	25	60									
DLGAP3	58512	broad.mit.edu	37	1	35365869	35365869	+	Silent	SNP	C	C	T	rs139408471		TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr1:35365869C>T	uc001byc.2	-	2	1113	c.1113G>A	c.(1111-1113)CCG>CCA	p.P371P		NM_001080418	NP_001073887	O95886	DLGP3_HUMAN	discs, large (Drosophila) homolog-associated	371					cell-cell signaling	cell junction|postsynaptic density|postsynaptic membrane				ovary(3)	3		Myeloproliferative disorder(586;0.0393)				AGTCATCTTGCGGCACCTGCA	0.612		NaN											0	0	0	0.006122	0	18	187									
RSPO1	284654	broad.mit.edu	37	1	38079496	38079496	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr1:38079496G>A	uc001cbl.1	-	7	1293	c.505C>T	c.(505-507)CGG>TGG	p.R169W	RSPO1_uc001cbm.1_Missense_Mutation_p.R169W|RSPO1_uc009vvf.1_Missense_Mutation_p.R142W|RSPO1_uc009vvg.1_Intron	NM_001038633	NP_001033722	Q2MKA7	RSPO1_HUMAN	R-spondin1 precursor	169	TSP type-1.				positive regulation of canonical Wnt receptor signaling pathway|regulation of receptor internalization		heparin binding				0		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				GAGCCCCTCCGGAAACCACAG	0.627		NaN											0	0	0	0.00308	0	8	117									
LEPRE1	64175	broad.mit.edu	37	1	43224586	43224586	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr1:43224586C>G	uc001chv.2	-	4	990	c.877G>C	c.(877-879)GAG>CAG	p.E293Q	LEPRE1_uc001chw.2_Missense_Mutation_p.E293Q|LEPRE1_uc001chx.3_Missense_Mutation_p.E293Q	NM_022356	NP_071751	Q32P28	P3H1_HUMAN	leprecan 1 isoform 1	293					negative regulation of cell proliferation	endoplasmic reticulum|proteinaceous extracellular matrix	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-proline 3-dioxygenase activity			ovary(3)|lung(1)	4	Ovarian(52;0.00744)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)			L-Proline(DB00172)|Succinic acid(DB00139)|Vitamin C(DB00126)	AAGGGCTTCTCTCGACTTGGG	0.443		NaN											0	0	0	0.00361	0	51	63									
TIE1	7075	broad.mit.edu	37	1	43778138	43778138	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr1:43778138C>T	uc001ciu.2	+	12	1872	c.1793C>T	c.(1792-1794)TCA>TTA	p.S598L	TIE1_uc010okd.1_Missense_Mutation_p.S598L|TIE1_uc010oke.1_Missense_Mutation_p.S553L|TIE1_uc009vwq.2_Missense_Mutation_p.S554L|TIE1_uc010okf.1_Missense_Mutation_p.S243L|TIE1_uc010okg.1_Missense_Mutation_p.S243L	NM_005424	NP_005415	P35590	TIE1_HUMAN	tyrosine kinase with immunoglobulin-like and	598	Fibronectin type-III 2.|Extracellular (Potential).				mesoderm development	integral to plasma membrane	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity			lung(3)|stomach(1)|salivary_gland(1)|ovary(1)|skin(1)	7	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				GAGAACGTCTCATCCCCCCAG	0.706		NaN											0	0	0	0.001168	0	5	42									
SLC6A9	6536	broad.mit.edu	37	1	44482736	44482736	+	Missense_Mutation	SNP	G	G	T			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr1:44482736G>T	uc001cll.2	-	1	262	c.70C>A	c.(70-72)CCC>ACC	p.P24T	SLC6A9_uc009vxe.2_5'Flank|SLC6A9_uc010okm.1_Intron|SLC6A9_uc001clm.2_Missense_Mutation_p.P24T|SLC6A9_uc009vxd.2_RNA|SLC6A9_uc010okn.1_Missense_Mutation_p.P24T|SLC6A9_uc001cln.2_Intron|SLC6A9_uc010oko.1_Intron|SLC6A9_uc010okp.1_Intron	NM_201649	NP_964012	P48067	SC6A9_HUMAN	solute carrier family 6 member 9 isoform 2	24	Cytoplasmic (Potential).					integral to plasma membrane|membrane fraction	glycine:sodium symporter activity|neurotransmitter:sodium symporter activity				0	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0511)			Glycine(DB00145)	GGGGAAGAGGGGGCCACAGGT	0.677		NaN											1	0	7.07596e-05	0.006122	7.30378e-05	14	59									
PRDX1	5052	broad.mit.edu	37	1	45981460	45981460	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr1:45981460G>C	uc001cnz.2	-	2	158	c.126C>G	c.(124-126)TTC>TTG	p.F42L	PRDX1_uc001coa.2_Missense_Mutation_p.F42L|PRDX1_uc001cob.2_Missense_Mutation_p.F42L|PRDX1_uc001coc.2_Missense_Mutation_p.F42L	NM_181697	NP_859048	Q06830	PRDX1_HUMAN	peroxiredoxin 1	42	Thioredoxin.				cell proliferation|cell redox homeostasis|hydrogen peroxide catabolic process|skeletal system development	melanosome|mitochondrion|nucleus	protein binding|thioredoxin peroxidase activity				0	Acute lymphoblastic leukemia(166;0.155)					GAGGGTAAAAGAAGAACACAA	0.408		NaN											0	0	0	0.00361	0	67	57									
CCDC17	149483	broad.mit.edu	37	1	46086690	46086690	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr1:46086690G>A	uc010olt.1	-	11	1632	c.1484C>T	c.(1483-1485)TCA>TTA	p.S495L	CCDC17_uc009vxy.2_Missense_Mutation_p.S463L|CCDC17_uc010ols.1_Missense_Mutation_p.S486L|CCDC17_uc001com.3_Missense_Mutation_p.S316L|CCDC17_uc001con.3_RNA|CCDC17_uc009vxz.2_Intron	NM_001114938	NP_001108410	Q96LX7	CCD17_HUMAN	coiled-coil domain containing 17	495										ovary(1)	1	Acute lymphoblastic leukemia(166;0.155)					TAGTCCAAGTGAGACCCAAGC	0.592		NaN											0	0	0	0.005443	0	26	26									
LRRC41	10489	broad.mit.edu	37	1	46744710	46744710	+	Missense_Mutation	SNP	G	G	T			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr1:46744710G>T	uc001cpn.2	-	10	2310	c.2266C>A	c.(2266-2268)CTG>ATG	p.L756M	LRRC41_uc010omb.1_3'UTR	NM_006369	NP_006360	Q15345	LRC41_HUMAN	MUF1 protein	756										ovary(2)|breast(1)|pancreas(1)	4	Acute lymphoblastic leukemia(166;0.155)					CAGCGCTCCAGCCGCTTGGCG	0.582		NaN											1	0	1.5842e-08	0.001855	1.69292e-08	11	64									
ZYG11B	79699	broad.mit.edu	37	1	53287142	53287142	+	Missense_Mutation	SNP	A	A	C			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr1:53287142A>C	uc001cuj.2	+	14	2271	c.2076A>C	c.(2074-2076)GAA>GAC	p.E692D	ZYG11B_uc010onj.1_Missense_Mutation_p.E613D|ZYG11B_uc009vzh.2_Missense_Mutation_p.E114D	NM_024646	NP_078922	Q9C0D3	ZY11B_HUMAN	zyg-11 homolog B	692							protein binding			upper_aerodigestive_tract(2)|ovary(1)|pancreas(1)	4						TGATTGAAGAAGGAGGATTGC	0.358		NaN											0	0	0	0.009096	0	4	55									
PODN	127435	broad.mit.edu	37	1	53544320	53544320	+	Missense_Mutation	SNP	C	C	A			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr1:53544320C>A	uc001cuv.2	+	8	1289	c.1282C>A	c.(1282-1284)CGC>AGC	p.R428S	PODN_uc001cuw.2_Missense_Mutation_p.R409S|PODN_uc010onr.1_Missense_Mutation_p.R409S|PODN_uc010ons.1_Missense_Mutation_p.R286S	NM_153703	NP_714914	Q7Z5L7	PODN_HUMAN	podocan	380	LRR 12.				negative regulation of cell migration|negative regulation of cell proliferation	cytoplasm|extracellular space|proteinaceous extracellular matrix	collagen binding			ovary(1)|pancreas(1)	2						TGGCCTGCCTCGCCGCGTGCG	0.632		NaN											1	0	1.76056e-25	0.011902	2.00733e-25	44	148									
USP1	7398	broad.mit.edu	37	1	62916526	62916526	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr1:62916526G>C	uc001daj.1	+	9	2560	c.2232G>C	c.(2230-2232)GAG>GAC	p.E744D	USP1_uc001dak.1_Missense_Mutation_p.E744D|USP1_uc001dal.1_Missense_Mutation_p.E744D	NM_001017415	NP_001017415	O94782	UBP1_HUMAN	ubiquitin specific protease 1	744					DNA repair|monoubiquitinated protein deubiquitination|regulation of DNA repair|response to UV|ubiquitin-dependent protein catabolic process	nucleoplasm	cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(1)	1		all_neural(321;0.0281)		BRCA - Breast invasive adenocarcinoma(111;8.01e-05)|KIRC - Kidney renal clear cell carcinoma(1967;0.00245)|OV - Ovarian serous cystadenocarcinoma(397;0.0535)		AGGAGTATGAGGGGAAGTGGT	0.373		NaN											0	0	0	0.010729	0	12	56									
SGIP1	84251	broad.mit.edu	37	1	67155919	67155919	+	Missense_Mutation	SNP	T	T	C			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr1:67155919T>C	uc001dcr.2	+	17	1707	c.1490T>C	c.(1489-1491)ATA>ACA	p.I497T	SGIP1_uc010opd.1_Missense_Mutation_p.I97T|SGIP1_uc001dcs.2_Missense_Mutation_p.I97T|SGIP1_uc001dct.2_Missense_Mutation_p.I97T|SGIP1_uc009wat.2_Missense_Mutation_p.I291T	NM_032291	NP_115667	Q9BQI5	SGIP1_HUMAN	SH3-domain GRB2-like (endophilin) interacting	497	Pro-rich.				positive regulation of energy homeostasis|positive regulation of feeding behavior|positive regulation of receptor-mediated endocytosis|response to dietary excess	AP-2 adaptor complex	microtubule binding|phospholipid binding|SH3 domain binding			ovary(3)	3						CCTCCTCCAATAGCACCCTTA	0.458		NaN											0	0	0	0.007413	0	17	235									
ABCD3	5825	broad.mit.edu	37	1	94943841	94943841	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr1:94943841C>G	uc001dqn.3	+	8	756	c.654C>G	c.(652-654)ATC>ATG	p.I218M	ABCD3_uc001dqm.3_Missense_Mutation_p.I218M|ABCD3_uc010oto.1_Missense_Mutation_p.I242M|ABCD3_uc010otp.1_Missense_Mutation_p.I145M|ABCD3_uc009wdr.2_Missense_Mutation_p.I218M	NM_002858	NP_002849	P28288	ABCD3_HUMAN	ATP-binding cassette, sub-family D, member 3	218	ABC transmembrane type-1.				peroxisomal long-chain fatty acid import|peroxisome organization	cytosol|integral to peroxisomal membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			skin(1)	1		all_lung(203;0.000434)|Lung NSC(277;0.0019)		all cancers(265;0.0261)|Epithelial(280;0.165)		TTTTGTATATCTTTAAGTTAA	0.259		NaN											0	0	0	0.000602	0	4	27									
KCNA2	3737	broad.mit.edu	37	1	111146504	111146504	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr1:111146504C>T	uc001dzu.2	-	2	1397	c.901G>A	c.(901-903)GTC>ATC	p.V301I	KCNA2_uc009wfv.1_Intron|KCNA2_uc009wfw.2_Missense_Mutation_p.V301I	NM_004974	NP_004965	P16389	KCNA2_HUMAN	potassium voltage-gated channel, shaker-related	301	Helical; Voltage-sensor; Name=Segment S4; (Potential).					juxtaparanode region of axon|voltage-gated potassium channel complex	delayed rectifier potassium channel activity			ovary(1)	1		all_cancers(81;5.55e-06)|all_epithelial(167;1.87e-05)|all_lung(203;0.000199)|Lung NSC(277;0.000398)		Colorectal(144;0.00878)|Lung(183;0.0234)|all cancers(265;0.0492)|Epithelial(280;0.0529)|COAD - Colon adenocarcinoma(174;0.131)|LUSC - Lung squamous cell carcinoma(189;0.133)|READ - Rectum adenocarcinoma(129;0.191)		ATCCTAAAGACTCTTACCAAC	0.527		NaN											0	0	0	0.004289	0	37	162									
TSPAN2	10100	broad.mit.edu	37	1	115600206	115600206	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr1:115600206G>C	uc001eft.2	-	6	530	c.468C>G	c.(466-468)AGC>AGG	p.S156R		NM_005725	NP_005716	O60636	TSN2_HUMAN	tetraspan 2	156	Extracellular (Potential).					integral to membrane					0	Lung SC(450;0.211)	all_cancers(81;2.9e-07)|all_epithelial(167;1.42e-06)|all_lung(203;6.72e-06)|Lung NSC(69;1.13e-05)|Acute lymphoblastic leukemia(138;0.191)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)|all cancers(265;0.159)|Epithelial(280;0.179)		CCTGTTCGGAGCTTTCTTTTC	0.493		NaN											0	0	0	0.007291	0	23	269									
ITGA10	8515	broad.mit.edu	37	1	145534181	145534181	+	Silent	SNP	T	T	C			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr1:145534181T>C	uc001eoa.2	+	14	1762	c.1686T>C	c.(1684-1686)GAT>GAC	p.D562D	NBPF10_uc001emp.3_Intron|ITGA10_uc010oyv.1_Silent_p.D431D|ITGA10_uc009wiw.2_Silent_p.D419D|ITGA10_uc010oyw.1_Silent_p.D507D	NM_003637	NP_003628	O75578	ITA10_HUMAN	integrin, alpha 10 precursor	562	Potential.|Extracellular (Potential).|FG-GAP 6.				cell-matrix adhesion|integrin-mediated signaling pathway	integrin complex	collagen binding|receptor activity			lung(2)|ovary(2)|kidney(2)|large_intestine(1)|skin(1)	8	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					TGAACCAAGATGGTTTTGCTG	0.582		NaN											0	0	0	0.005524	0	37	489									
C1orf54	79630	broad.mit.edu	37	1	150246527	150246527	+	Missense_Mutation	SNP	T	T	A			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr1:150246527T>A	uc001eud.2	+	2	122	c.84T>A	c.(82-84)GAT>GAA	p.D28E	C1orf54_uc001euc.2_Missense_Mutation_p.D28E|C1orf54_uc001eue.2_Missense_Mutation_p.D28E|C1orf54_uc001euf.2_Missense_Mutation_p.D28E|C1orf54_uc001eug.2_Missense_Mutation_p.D28E	NM_024579	NP_078855	Q8WWF1	CA054_HUMAN	hypothetical protein LOC79630 precursor	28						extracellular region					0	Lung NSC(24;7.29e-29)|Breast(34;0.00211)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.161)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.171)			TGGGAGAGGATGAATATTATC	0.448		NaN											0	0	0	0.012213	0	30	325									
SETDB1	9869	broad.mit.edu	37	1	150915383	150915383	+	Silent	SNP	G	G	A			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr1:150915383G>A	uc001evu.2	+	7	919	c.729G>A	c.(727-729)TCG>TCA	p.S243S	SETDB1_uc009wmf.2_Silent_p.S243S|SETDB1_uc001evv.2_Silent_p.S243S|SETDB1_uc001evw.3_Silent_p.S243S|SETDB1_uc009wmg.1_Silent_p.S243S	NM_001145415	NP_001138887	Q15047	SETB1_HUMAN	SET domain, bifurcated 1 isoform 1	243					regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|Golgi apparatus|nucleus|plasma membrane	DNA binding|histone-lysine N-methyltransferase activity|protein binding|zinc ion binding			ovary(2)|upper_aerodigestive_tract(1)	3	all_lung(15;9e-35)|Lung NSC(24;3.45e-31)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.108)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|BRCA - Breast invasive adenocarcinoma(12;0.0152)|LUSC - Lung squamous cell carcinoma(543;0.211)			GTCTACTGTCGGGGAACCATA	0.453		NaN											0	0	0	0.008871	0	17	260									
FLG	2312	broad.mit.edu	37	1	152279926	152279926	+	Missense_Mutation	SNP	T	T	G			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr1:152279926T>G	uc001ezu.1	-	3	7472	c.7436A>C	c.(7435-7437)GAG>GCG	p.E2479A		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	2479	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TACCAATTGCTCGTAGTGGGA	0.572		NaN							Ichthyosis				0	0	0	0.00361	0	74	870									
DCST1	149095	broad.mit.edu	37	1	155018907	155018907	+	Silent	SNP	C	C	T			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr1:155018907C>T	uc001fgn.1	+	13	1536	c.1440C>T	c.(1438-1440)CTC>CTT	p.L480L	DCST1_uc010per.1_Silent_p.L505L|DCST1_uc010pes.1_Silent_p.L455L|uc001fgo.2_Intron	NM_152494	NP_689707	Q5T197	DCST1_HUMAN	DC-STAMP domain containing 1 isoform 1	480	Helical; (Potential).					integral to membrane	zinc ion binding			ovary(1)|skin(1)	2	all_epithelial(22;1.43e-30)|all_lung(78;6.64e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		BRCA - Breast invasive adenocarcinoma(34;0.000434)			ACTGGGCTCTCTACTCCATCT	0.612		NaN											0	0	0	0.004007	0	16	186									
THBS3	7059	broad.mit.edu	37	1	155172605	155172605	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr1:155172605C>T	uc001fix.2	-	8	978	c.955G>A	c.(955-957)GAG>AAG	p.E319K	RAG1AP1_uc010pey.1_Intron|THBS3_uc009wqi.2_Missense_Mutation_p.E310K|THBS3_uc001fiz.2_Missense_Mutation_p.E319K|THBS3_uc001fiy.2_5'UTR|THBS3_uc010pfu.1_Missense_Mutation_p.E199K|THBS3_uc010pfv.1_RNA|THBS3_uc001fja.2_RNA	NM_007112	NP_009043	P49746	TSP3_HUMAN	thrombospondin 3 precursor	319	EGF-like 2; calcium-binding (Potential).				cell-matrix adhesion	extracellular region|perinuclear region of cytoplasm	calcium ion binding|heparin binding|structural molecule activity			breast(3)|ovary(2)	5	all_epithelial(22;5.72e-28)|all_lung(78;2.07e-24)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		Epithelial(20;3.72e-10)|all cancers(21;1.19e-09)|BRCA - Breast invasive adenocarcinoma(34;0.000752)|LUSC - Lung squamous cell carcinoma(543;0.193)			TCCCTCACCTCATTGATGTCA	0.607		NaN											0	0	0	0.00361	0	42	143									
DAP3	7818	broad.mit.edu	37	1	155698905	155698905	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr1:155698905G>A	uc001flq.2	+	8	845	c.676G>A	c.(676-678)GTT>ATT	p.V226I	DAP3_uc001flr.2_Missense_Mutation_p.V226I|DAP3_uc001fls.2_Missense_Mutation_p.V226I|DAP3_uc010pgl.1_Missense_Mutation_p.V185I|DAP3_uc001flt.2_Missense_Mutation_p.V192I|DAP3_uc001flu.2_Intron|DAP3_uc010pgm.1_Missense_Mutation_p.V192I	NM_033657	NP_387506	P51398	RT29_HUMAN	death-associated protein 3	226					induction of apoptosis by extracellular signals	mitochondrial ribosome|nucleolus|small ribosomal subunit	protein binding			ovary(1)	1	Hepatocellular(266;0.0997)|all_hematologic(923;0.145)					GGGAGAAGTGGTTGAACAGGT	0.398		NaN											0	0	0	0.008291	0	10	152									
KIAA0907	22889	broad.mit.edu	37	1	155887393	155887393	+	Missense_Mutation	SNP	T	T	G			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr1:155887393T>G	uc001fmi.1	-	11	1361	c.1337A>C	c.(1336-1338)CAG>CCG	p.Q446P	KIAA0907_uc001fmj.1_Missense_Mutation_p.Q446P|KIAA0907_uc009wrk.1_Missense_Mutation_p.Q303P|KIAA0907_uc009wrl.1_RNA	NM_014949	NP_055764	Q7Z7F0	K0907_HUMAN	hypothetical protein LOC22889	446	Pro-rich.										0	Hepatocellular(266;0.133)|all_hematologic(923;0.145)|all_neural(408;0.195)		OV - Ovarian serous cystadenocarcinoma(3;8.82e-06)			gggctggggctggggctgggg	0.448		NaN											0	0	0	0.007291	0	21	91									
RXFP4	339403	broad.mit.edu	37	1	155912334	155912334	+	Silent	SNP	C	C	T			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr1:155912334C>T	uc010pgs.1	+	1	855	c.834C>T	c.(832-834)CCC>CCT	p.P278P		NM_181885	NP_871001	Q8TDU9	RL3R2_HUMAN	relaxin 3 receptor 2	278	Extracellular (Potential).					integral to membrane|plasma membrane	angiotensin type II receptor activity				0	Hepatocellular(266;0.133)|all_hematologic(923;0.145)|all_neural(408;0.195)					ACCTGGTGCCCTGGAACAGTA	0.537		NaN											0	0	0	0.00361	0	172	204									
ARHGAP30	257106	broad.mit.edu	37	1	161021373	161021373	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr1:161021373G>C	uc001fxl.2	-	10	1497	c.1151C>G	c.(1150-1152)TCT>TGT	p.S384C	ARHGAP30_uc001fxk.2_Missense_Mutation_p.S384C|ARHGAP30_uc001fxm.2_Missense_Mutation_p.S230C|ARHGAP30_uc009wtx.2_Missense_Mutation_p.S57C|ARHGAP30_uc001fxn.1_Missense_Mutation_p.S230C	NM_001025598	NP_001020769	Q7Z6I6	RHG30_HUMAN	Rho GTPase activating protein 30 isoform 1	384					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			ovary(2)|upper_aerodigestive_tract(1)	3	all_cancers(52;8.05e-20)|Breast(13;0.00188)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00122)			GCCTGGTTCAGAGTTTGTGCC	0.607		NaN											0	0	0	0.00361	0	47	257									
USP21	27005	broad.mit.edu	37	1	161130596	161130596	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr1:161130596C>T	uc010pke.1	+	3	543	c.166C>T	c.(166-168)CCA>TCA	p.P56S	USP21_uc010pkc.1_Missense_Mutation_p.P56S|USP21_uc010pkd.1_Missense_Mutation_p.P56S|USP21_uc010pkf.1_Missense_Mutation_p.P56S	NM_001014443	NP_001014443	Q9UK80	UBP21_HUMAN	ubiquitin-specific protease 21	56					histone deubiquitination|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent|ubiquitin-dependent protein catabolic process	nucleus	metal ion binding|NEDD8-specific protease activity|protein binding|transcription coactivator activity|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(2)|lung(1)|prostate(1)|breast(1)	5	all_cancers(52;3.73e-19)|Breast(13;0.000577)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00275)			GCCTCCCCGGCCAGGTCTGCC	0.642		NaN											0	0	0	0.008291	0	11	242									
OLFML2B	25903	broad.mit.edu	37	1	161954646	161954646	+	Silent	SNP	A	A	G			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr1:161954646A>G	uc001gbu.2	-	7	2023	c.1599T>C	c.(1597-1599)TAT>TAC	p.Y533Y	OLFML2B_uc001gbt.2_Silent_p.Y16Y|OLFML2B_uc010pkq.1_Silent_p.Y534Y	NM_015441	NP_056256	Q68BL8	OLM2B_HUMAN	olfactomedin-like 2B precursor	533	Olfactomedin-like.									skin(1)	1	all_hematologic(112;0.156)		BRCA - Breast invasive adenocarcinoma(70;0.0172)			TGCCGTAGTAATAGTTGGTTA	0.537		NaN											0	0	0	0.00361	0	76	382									
ILDR2	387597	broad.mit.edu	37	1	166927059	166927059	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr1:166927059G>A	uc001gdx.1	-	2	382	c.326C>T	c.(325-327)TCG>TTG	p.S109L		NM_199351	NP_955383	Q71H61	ILDR2_HUMAN	immunoglobulin-like domain containing receptor	109	Ig-like V-type.|Extracellular (Potential).					integral to membrane				ovary(1)	1						GGTGACAGTCGAGCCCTGTTT	0.493		NaN											0	0	0	0.00361	0	46	174									
KLHL20	27252	broad.mit.edu	37	1	173754326	173754326	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr1:173754326C>T	uc001gjc.2	+	12	1950	c.1771C>T	c.(1771-1773)CGG>TGG	p.R591W	KLHL20_uc010pmr.1_Missense_Mutation_p.R402W|KLHL20_uc009wwf.2_Missense_Mutation_p.R573W	NM_014458	NP_055273	Q9Y2M5	KLH20_HUMAN	kelch-like 20	591	Kelch 6.				cytoskeleton organization|negative regulation of apoptosis|proteasomal ubiquitin-dependent protein catabolic process|response to interferon-alpha	actin cytoskeleton|cell surface|Cul3-RING ubiquitin ligase complex|Golgi apparatus|perinuclear region of cytoplasm|PML body	actin binding|interferon-gamma binding|ubiquitin-protein ligase activity			ovary(1)	1						GAATTACCGTCGGCTAGGGGG	0.363		NaN											0	0	0	0.004878	0	32	44									
TNR	7143	broad.mit.edu	37	1	175336348	175336348	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr1:175336348C>G	uc001gkp.1	-	8	2130	c.2049G>C	c.(2047-2049)AGG>AGC	p.R683S	TNR_uc009wwu.1_Missense_Mutation_p.R683S	NM_003285	NP_003276	Q92752	TENR_HUMAN	tenascin R precursor	683	Fibronectin type-III 4.				axon guidance|cell adhesion|signal transduction	proteinaceous extracellular matrix				pancreas(5)|ovary(4)|central_nervous_system(1)|skin(1)	11	Renal(580;0.146)					ACTCACCAGTCCTGGCATTCA	0.493		NaN											0	0	0	0.010818	0	27	85									
HMCN1	83872	broad.mit.edu	37	1	186094817	186094817	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr1:186094817G>C	uc001grq.1	+	82	12810	c.12581G>C	c.(12580-12582)GGA>GCA	p.G4194A	HMCN1_uc001grs.1_5'Flank	NM_031935	NP_114141	Q96RW7	HMCN1_HUMAN	hemicentin 1 precursor	4194	Ig-like C2-type 41.				response to stimulus|visual perception	basement membrane	calcium ion binding			ovary(22)|skin(1)	23						GTAGCTGATGGAATCCCCACA	0.388		NaN											0	0	0	0.00632	0	26	70									
HMCN1	83872	broad.mit.edu	37	1	186114897	186114897	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr1:186114897G>A	uc001grq.1	+	93	14679	c.14450G>A	c.(14449-14451)TGG>TAG	p.W4817*	HMCN1_uc001grs.1_Nonsense_Mutation_p.W386*	NM_031935	NP_114141	Q96RW7	HMCN1_HUMAN	hemicentin 1 precursor	4817	TSP type-1 6.				response to stimulus|visual perception	basement membrane	calcium ion binding			ovary(22)|skin(1)	23						GATGGAAGTTGGGGAAGCTGG	0.498		NaN											0	0	0	0.00361	0	60	75									
ASPM	259266	broad.mit.edu	37	1	197073065	197073065	+	Silent	SNP	C	C	T			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr1:197073065C>T	uc001gtu.2	-	18	5573	c.5316G>A	c.(5314-5316)CTG>CTA	p.L1772L	ASPM_uc001gtv.2_Intron|ASPM_uc001gtw.3_Intron	NM_018136	NP_060606	Q8IZT6	ASPM_HUMAN	asp (abnormal spindle)-like, microcephaly	1772	IQ 7.				mitosis	cytoplasm|nucleus	calmodulin binding			ovary(4)|central_nervous_system(2)	6						TATACATTTTCAGATAATACT	0.358		NaN											0	0	0	0.001855	0	14	90									
LGTN	1939	broad.mit.edu	37	1	206782760	206782760	+	Silent	SNP	A	A	C			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr1:206782760A>C	uc001heh.2	-	3	509	c.300T>G	c.(298-300)CCT>CCG	p.P100P	LGTN_uc009xbw.2_Silent_p.P100P|LGTN_uc010prw.1_Silent_p.P100P	NM_006893	NP_008824	P41214	EIF2D_HUMAN	ligatin	100	PUA.				intracellular protein transport	cytoplasm	protein binding|receptor activity|translation initiation factor activity				0	Breast(84;0.183)		BRCA - Breast invasive adenocarcinoma(75;0.166)			CGAGCACCAGAGGCCATGTTG	0.438		NaN											0	0	0	0.001368	0	12	105									
NENF	29937	broad.mit.edu	37	1	212617721	212617721	+	Silent	SNP	G	G	A			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr1:212617721G>A	uc001hjd.2	+	3	336	c.279G>A	c.(277-279)GGG>GGA	p.G93G	NENF_uc010ptf.1_RNA	NM_013349	NP_037481	Q9UMX5	NENF_HUMAN	neuron derived neurotrophic factor precursor	93	Cytochrome b5 heme-binding.					extracellular space	heme binding				0				all cancers(67;0.00967)|OV - Ovarian serous cystadenocarcinoma(81;0.0108)|GBM - Glioblastoma multiforme(131;0.0325)|Epithelial(68;0.132)		CCTTGACGGGGAAGGACTCCA	0.512		NaN											0	0	0	0.001368	0	12	93									
KCTD3	51133	broad.mit.edu	37	1	215792292	215792292	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr1:215792292G>A	uc001hks.2	+	16	1921	c.1627G>A	c.(1627-1629)GGA>AGA	p.G543R	KCTD3_uc001hkt.2_Missense_Mutation_p.G543R|KCTD3_uc010pub.1_Missense_Mutation_p.G441R|KCTD3_uc009xdn.2_Missense_Mutation_p.G267R	NM_016121	NP_057205	Q9Y597	KCTD3_HUMAN	potassium channel tetramerisation domain	543	WD 5.					voltage-gated potassium channel complex	protein binding|voltage-gated potassium channel activity			ovary(3)	3				all cancers(67;0.0164)|OV - Ovarian serous cystadenocarcinoma(81;0.019)|GBM - Glioblastoma multiforme(131;0.0862)|Epithelial(68;0.13)		GGAATGTGAGGGATCCAGTAG	0.453		NaN											0	0	0	0.006214	0	8	107									
BPNT1	10380	broad.mit.edu	37	1	220233036	220233036	+	Missense_Mutation	SNP	G	G	T			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr1:220233036G>T	uc001hma.2	-	8	942	c.770C>A	c.(769-771)GCT>GAT	p.A257D	BPNT1_uc010pug.1_Missense_Mutation_p.A202D|BPNT1_uc010puh.1_Missense_Mutation_p.A221D|BPNT1_uc001hmb.3_Missense_Mutation_p.A272D	NM_006085	NP_006076	O95861	BPNT1_HUMAN	3'(2'), 5'-bisphosphate nucleotidase 1	257					3'-phosphoadenosine 5'-phosphosulfate metabolic process|nervous system development|xenobiotic metabolic process	cytosol	3'(2'),5'-bisphosphate nucleotidase activity			ovary(1)	1				GBM - Glioblastoma multiforme(131;0.0558)		ACCTCCCACAGCATGTAAAAT	0.338		NaN											1	0	1.5842e-08	0.001855	1.69292e-08	14	136									
AIDA	64853	broad.mit.edu	37	1	222867175	222867175	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr1:222867175G>C	uc001hnn.2	-	4	450	c.245C>G	c.(244-246)TCT>TGT	p.S82C	AIDA_uc001hno.2_RNA|AIDA_uc010pus.1_Missense_Mutation_p.S58C	NM_022831	NP_073742	Q96BJ3	AIDA_HUMAN	axin interactor, dorsalization associated	82					dorsal/ventral pattern formation|negative regulation of JNK cascade|negative regulation of JUN kinase activity|regulation of protein homodimerization activity						0						TTCTTCTTGAGACTGTGTGGA	0.313		NaN											0	0	0	0.010729	0	11	26									
LYST	1130	broad.mit.edu	37	1	235884050	235884050	+	Silent	SNP	G	G	A			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr1:235884050G>A	uc001hxj.2	-	40	9646	c.9471C>T	c.(9469-9471)TTC>TTT	p.F3157F	LYST_uc001hxi.2_Silent_p.F381F	NM_000081	NP_000072	Q99698	LYST_HUMAN	lysosomal trafficking regulator	3157	BEACH.				defense response to bacterium|defense response to protozoan|defense response to virus|endosome to lysosome transport via multivesicular body sorting pathway|leukocyte chemotaxis|mast cell secretory granule organization|melanosome organization|natural killer cell mediated cytotoxicity|protein transport	cytoplasm|microtubule cytoskeleton	protein binding			ovary(6)|breast(4)|central_nervous_system(2)	12	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.00246)|Prostate(94;0.0771)|Acute lymphoblastic leukemia(190;0.228)	OV - Ovarian serous cystadenocarcinoma(106;0.000674)			TGAGATCATTGAAGGATCGGC	0.363		NaN							Chediak-Higashi_syndrome				0	0	0	0.005524	0	38	112									
TUBB8	347688	broad.mit.edu	37	10	95170	95170	+	Silent	SNP	C	C	T			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr10:95170C>T	uc001ifi.2	-	1	9	c.9G>A	c.(7-9)GAG>GAA	p.E3E	TUBB8_uc009xhe.2_Silent_p.E3E|TUBB8_uc010pzs.1_Intron	NM_177987	NP_817124	Q3ZCM7	TBB8_HUMAN	tubulin, beta 8 isoform 1	3					microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|structural molecule activity			ovary(1)	1		all_cancers(4;0.00131)|all_lung(4;0.000777)|Lung NSC(4;0.0043)|all_epithelial(10;0.0154)|Colorectal(49;0.235)		Epithelial(11;0.00341)|all cancers(11;0.00922)|OV - Ovarian serous cystadenocarcinoma(14;0.0508)|Lung(33;0.132)		TGAGCACGATCTCCCTCATGG	0.672		NaN											0	0	0	0.009096	0	3	8									
CUBN	8029	broad.mit.edu	37	10	17107518	17107518	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr10:17107518C>T	uc001ioo.2	-	22	3180	c.3128G>A	c.(3127-3129)AGT>AAT	p.S1043N		NM_001081	NP_001072	O60494	CUBN_HUMAN	cubilin precursor	1043					cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			ovary(9)|breast(4)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|kidney(1)	19					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	TGTTGCTGCACTGATTGCTTC	0.423		NaN											0	0	0	0.00361	0	54	217									
ARMC3	219681	broad.mit.edu	37	10	23250840	23250840	+	Nonsense_Mutation	SNP	G	G	T			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr10:23250840G>T	uc001irm.3	+	7	648	c.565G>T	c.(565-567)GAA>TAA	p.E189*	ARMC3_uc010qcv.1_Nonsense_Mutation_p.E189*|ARMC3_uc010qcw.1_Intron	NM_173081	NP_775104	Q5W041	ARMC3_HUMAN	armadillo repeat containing 3	189	ARM 5.						binding				0						TAAACTTCAAGAACTAAATGC	0.333		NaN											1	0	0.00198382	0.001984	0.00203612	6	24									
AGAP6	414189	broad.mit.edu	37	10	51749116	51749116	+	Missense_Mutation	SNP	A	A	G			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr10:51749116A>G	uc001jix.3	+	2	670	c.272A>G	c.(271-273)CAG>CGG	p.Q91R		NM_001077665	NP_001071133	Q5VW22	AGAP6_HUMAN	ArfGAP with GTPase domain, ankyrin repeat and PH	91					regulation of ARF GTPase activity		ARF GTPase activator activity|zinc ion binding			skin(1)	1						ACAATATTCCAGAGGAACTCT	0.353		NaN											0	0	0	0.001168	0	5	53									
C10orf35	219738	broad.mit.edu	37	10	71392625	71392625	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr10:71392625C>T	uc001jpq.3	+	4	346	c.176C>T	c.(175-177)GCT>GTT	p.A59V		NM_145306	NP_660349	Q96D05	CJ035_HUMAN	hypothetical protein LOC219738	59						integral to membrane				ovary(1)|skin(1)	2						AGGCTGGGTGCTGCTCAGTCC	0.627		NaN											0	0	0	0.001168	0	5	84									
LRIT1	26103	broad.mit.edu	37	10	85991892	85991892	+	Missense_Mutation	SNP	G	G	A	rs75121307		TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr10:85991892G>A	uc001kcz.1	-	4	1685	c.1663C>T	c.(1663-1665)CGC>TGC	p.R555C		NM_015613	NP_056428	Q9P2V4	LRIT1_HUMAN	retina specific protein PAL	555	Cytoplasmic (Potential).					integral to endoplasmic reticulum membrane					0						TTTCGGCAGCGCTTCTGAAGA	0.552		NaN											0	0	0	0.002836	0	36	52									
STAMBPL1	57559	broad.mit.edu	37	10	90672881	90672881	+	Silent	SNP	C	C	G			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr10:90672881C>G	uc001kfk.2	+	6	867	c.444C>G	c.(442-444)CTC>CTG	p.L148L	STAMBPL1_uc010qmx.1_Silent_p.L148L|STAMBPL1_uc009xto.2_RNA|STAMBPL1_uc001kfl.2_Silent_p.L148L|STAMBPL1_uc001kfn.2_5'UTR	NM_020799	NP_065850	Q96FJ0	STALP_HUMAN	STAM binding protein-like 1	148							metal ion binding|metallopeptidase activity|protein binding			ovary(1)	1		Colorectal(252;0.0381)		Colorectal(12;6.38e-05)|COAD - Colon adenocarcinoma(12;7.75e-05)		CTGAAATTCTCAAAAAATTGG	0.408		NaN											0	0	0	0.002836	0	34	84									
BTAF1	9044	broad.mit.edu	37	10	93726464	93726464	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr10:93726464C>T	uc001khr.2	+	14	1698	c.1600C>T	c.(1600-1602)CGA>TGA	p.R534*	BTAF1_uc001khs.1_Nonsense_Mutation_p.R204*|BTAF1_uc001kht.1_5'UTR	NM_003972	NP_003963	O14981	BTAF1_HUMAN	BTAF1 RNA polymerase II, B-TFIID transcription	534	HEAT 3.				negative regulation of transcription, DNA-dependent	nucleus	ATP binding|DNA binding|helicase activity|sequence-specific DNA binding transcription factor activity			ovary(1)|central_nervous_system(1)|skin(1)	3		Colorectal(252;0.0846)				ATCATCAGTTCGAAGAGCAGC	0.338		NaN											0	0	0	0.002836	0	30	58									
CYP2C18	1562	broad.mit.edu	37	10	96454775	96454775	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr10:96454775C>T	uc001kjv.3	+	4	909	c.583C>T	c.(583-585)CTT>TTT	p.L195F	CYP2C18_uc001kjw.3_Missense_Mutation_p.L195F|CYP2C19_uc009xus.1_Intron|CYP2C19_uc010qny.1_5'UTR	NM_000772	NP_000763	P33260	CP2CI_HUMAN	cytochrome P450 family 2 subfamily C polypeptide	195					xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding			ovary(3)|lung(1)|skin(1)	5		Colorectal(252;0.09)		all cancers(201;2.8e-06)|KIRC - Kidney renal clear cell carcinoma(50;0.0646)|Kidney(138;0.0805)		TCAGAGGTTTCTTAACTTGAT	0.408		NaN											0	0	0	0.001168	0	6	68									
BLNK	29760	broad.mit.edu	37	10	97951794	97951794	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr10:97951794G>A	uc001kls.3	-	17	1484	c.1306C>T	c.(1306-1308)CTT>TTT	p.L436F	BLNK_uc001kme.3_Missense_Mutation_p.L331F|BLNK_uc001klt.3_Missense_Mutation_p.L327F|BLNK_uc009xvc.2_RNA|BLNK_uc001klu.3_Missense_Mutation_p.L302F|BLNK_uc001klv.3_Missense_Mutation_p.L279F|BLNK_uc001klw.3_RNA|BLNK_uc001klx.3_Missense_Mutation_p.L413F|BLNK_uc001kly.3_Missense_Mutation_p.L384F|BLNK_uc001klz.3_RNA|BLNK_uc001kma.3_Missense_Mutation_p.L361F|BLNK_uc001kmb.3_Missense_Mutation_p.L232F|BLNK_uc001kmc.3_RNA|BLNK_uc001kmd.3_Missense_Mutation_p.L354F|BLNK_uc009xvd.2_RNA	NM_013314	NP_037446	Q8WV28	BLNK_HUMAN	B-cell linker isoform 1	436	SH2.				B cell differentiation|humoral immune response|inflammatory response|intracellular signal transduction	cytoplasm|plasma membrane	SH3/SH2 adaptor activity|transmembrane receptor protein tyrosine kinase adaptor activity			skin(2)	2		Colorectal(252;0.083)		Epithelial(162;7.89e-08)|all cancers(201;2.27e-06)		CTGTCAATAAGAACCAAAGGA	0.343		NaN											0	0	0	0.00361	0	43	41									
PI4K2A	55361	broad.mit.edu	37	10	99400862	99400862	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr10:99400862C>G	uc001kog.1	+	1	420	c.363C>G	c.(361-363)ATC>ATG	p.I121M	PI4K2A_uc010qoy.1_Intron	NM_018425	NP_060895	Q9BTU6	P4K2A_HUMAN	phosphatidylinositol 4-kinase type 2 alpha	121					phosphatidylinositol biosynthetic process	cytoplasm|integral to plasma membrane|membrane raft	1-phosphatidylinositol 4-kinase activity|ATP binding|magnesium ion binding			lung(1)|skin(1)	2		Colorectal(252;0.162)		Epithelial(162;1.24e-10)|all cancers(201;1.2e-08)		AGCTGGCCATCGAGCGCTGCA	0.711		NaN											0	0	0	0.004482	0	8	28									
ADRB1	153	broad.mit.edu	37	10	115804383	115804383	+	Missense_Mutation	SNP	C	C	A			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr10:115804383C>A	uc001lba.2	+	1	578	c.492C>A	c.(490-492)TTC>TTA	p.F164L		NM_000684	NP_000675	P08588	ADRB1_HUMAN	beta-1-adrenergic receptor	164	Cytoplasmic (By similarity).				positive regulation of cAMP biosynthetic process	integral to plasma membrane	alpha-2A adrenergic receptor binding|beta1-adrenergic receptor activity|protein heterodimerization activity				0		Colorectal(252;0.172)|Breast(234;0.188)		Epithelial(162;0.0124)|all cancers(201;0.0298)	Acebutolol(DB01193)|Alprenolol(DB00866)|Amiodarone(DB01118)|Arbutamine(DB01102)|Atenolol(DB00335)|Betaxolol(DB00195)|Bevantolol(DB01295)|Bisoprolol(DB00612)|Bretylium(DB01158)|Carteolol(DB00521)|Carvedilol(DB01136)|Desipramine(DB01151)|Dobutamine(DB00841)|Dopamine(DB00988)|Epinephrine(DB00668)|Esmolol(DB00187)|Isoetharine(DB00221)|Isoproterenol(DB01064)|Labetalol(DB00598)|Levobunolol(DB01210)|Metipranolol(DB01214)|Metoprolol(DB00264)|Nadolol(DB01203)|Norepinephrine(DB00368)|Oxprenolol(DB01580)|Penbutolol(DB01359)|Pindolol(DB00960)|Practolol(DB01297)|Propranolol(DB00571)|Risperidone(DB00734)|Timolol(DB00373)|Ziprasidone(DB00246)	CCTCGCCCTTCCGCTACCAGA	0.572		NaN											1	0	1.08321e-29	0.00361	1.24546e-29	70	89									
TRUB1	142940	broad.mit.edu	37	10	116698112	116698112	+	Missense_Mutation	SNP	A	A	C			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr10:116698112A>C	uc001lcd.2	+	1	161	c.100A>C	c.(100-102)ACC>CCC	p.T34P	TRUB1_uc010qsl.1_Intron	NM_139169	NP_631908	Q8WWH5	TRUB1_HUMAN	TruB pseudouridine (psi) synthase homolog 1	34					pseudouridine synthesis|tRNA processing		pseudouridine synthase activity|RNA binding				0		Colorectal(252;0.09)|Breast(234;0.174)|Lung NSC(174;0.245)		Epithelial(162;0.00879)|all cancers(201;0.0243)		AATGGCTGCGACCCCGTCAGC	0.637		NaN											0	0	0	0.007413	0	5	5									
PNLIPRP1	5407	broad.mit.edu	37	10	118357370	118357370	+	Missense_Mutation	SNP	G	G	T			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr10:118357370G>T	uc001lco.1	+	7	623	c.605G>T	c.(604-606)AGT>ATT	p.S202I	PNLIPRP1_uc001lcp.2_Missense_Mutation_p.S202I|PNLIPRP1_uc009xys.1_RNA	NM_006229	NP_006220	P54315	LIPR1_HUMAN	pancreatic lipase-related protein 1 precursor	202					lipid metabolic process		calcium ion binding|triglyceride lipase activity			ovary(1)|breast(1)	2				all cancers(201;0.0161)		AGTTTCGAGAGTACTCCTGAA	0.468		NaN											1	0	4.96729e-08	0.008871	5.25665e-08	20	86									
B4GALNT4	338707	broad.mit.edu	37	11	373764	373764	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr11:373764G>A	uc001lpb.2	+	8	728	c.719G>A	c.(718-720)CGG>CAG	p.R240Q		NM_178537	NP_848632	Q76KP1	B4GN4_HUMAN	beta	240	Lumenal (Potential).					Golgi cisterna membrane|integral to membrane	N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity			pancreas(1)	1		all_cancers(49;1.59e-06)|all_epithelial(84;0.000256)|Breast(177;0.00122)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;1.56e-27)|Epithelial(43;9.31e-27)|OV - Ovarian serous cystadenocarcinoma(40;1.11e-20)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0182)|LUSC - Lung squamous cell carcinoma(625;0.0703)		ATGGCCTCCCGGAGGTACTAC	0.642		NaN											0	0	0	0.00361	0	47	37									
KRTAP5-5	439915	broad.mit.edu	37	11	1651190	1651190	+	Silent	SNP	C	C	T			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr11:1651190C>T	uc001lty.2	+	1	158	c.120C>T	c.(118-120)TCC>TCT	p.S40S		NM_001001480	NP_001001480	Q701N2	KRA55_HUMAN	keratin associated protein 5-5	40						keratin filament				lung(1)	1		all_epithelial(84;0.00018)|Ovarian(85;0.0014)|Breast(177;0.00147)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.000614)|Lung(200;0.0681)|LUSC - Lung squamous cell carcinoma(625;0.082)		gctgtggctccggctgtggag	0.104		NaN											0	0	0	0.00308	0	4	33									
SYT9	143425	broad.mit.edu	37	11	7335059	7335059	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr11:7335059G>C	uc001mfe.2	+	3	1168	c.931G>C	c.(931-933)GAC>CAC	p.D311H	SYT9_uc001mfd.2_RNA|SYT9_uc009yfi.2_Intron	NM_175733	NP_783860	Q86SS6	SYT9_HUMAN	synaptotagmin IX	311	Cytoplasmic (Potential).|C2 1.	Calcium 2 (By similarity).|Calcium 3 (By similarity).|Calcium 1 (By similarity).				cell junction|integral to membrane|synaptic vesicle membrane	metal ion binding|transporter activity			ovary(2)|large_intestine(1)	3				Epithelial(150;1.34e-07)|LUSC - Lung squamous cell carcinoma(625;0.0949)		GTACGACTTTGACAGGTTCTC	0.473		NaN											0	0	0	0.00361	0	69	141									
PAX6	5080	broad.mit.edu	37	11	31824258	31824258	+	Silent	SNP	A	A	T			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr11:31824258A>T	uc001mtd.3	-	4	1025	c.135T>A	c.(133-135)ATT>ATA	p.I45I	PAX6_uc001mte.3_Silent_p.I45I|PAX6_uc001mtg.3_Silent_p.I45I|PAX6_uc001mtf.3_Silent_p.I45I|PAX6_uc001mth.3_Silent_p.I45I|PAX6_uc009yjr.2_Silent_p.I45I	NM_001127612	NP_001121084	P26367	PAX6_HUMAN	paired box gene 6 isoform a	45	Paired.				blood vessel development|central nervous system development|cornea development in camera-type eye|glucose homeostasis|iris morphogenesis|negative regulation of neurogenesis|neuron fate commitment|pancreatic A cell development|positive regulation of transcription, DNA-dependent|response to wounding|visual perception	cytoplasm|nuclear chromatin	R-SMAD binding|RNA polymerase II core promoter sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity|ubiquitin-protein ligase activity			lung(4)|ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	9	Lung SC(675;0.225)					TCACCTGCAGAATTCGGGAAA	0.617		NaN							Wilms_tumor-Aniridia-ambiguous_Genitals-mental_Retardation				0	0	0	0.004007	0	16	8									
OR4C46	119749	broad.mit.edu	37	11	51515813	51515813	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr11:51515813G>C	uc010ric.1	+	1	532	c.532G>C	c.(532-534)GAT>CAT	p.D178H		NM_001004703	NP_001004703	A6NHA9	O4C46_HUMAN	olfactory receptor, family 4, subfamily C,	178	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						CTTTATGTGTGATCTGAACCC	0.453		NaN											0	0	0	0.001368	0	12	192									
OR8H2	390151	broad.mit.edu	37	11	55872777	55872777	+	Missense_Mutation	SNP	C	C	A			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr11:55872777C>A	uc010riy.1	+	1	259	c.259C>A	c.(259-261)CTG>ATG	p.L87M		NM_001005200	NP_001005200	Q8N162	OR8H2_HUMAN	olfactory receptor, family 8, subfamily H,	87	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	Esophageal squamous(21;0.00693)					AGCGAACTTACTGACTTCCAA	0.438		NaN								HNSCC(53;0.14)			1	0	1.66425e-11	0.004878	1.83235e-11	37	632									
RTN4RL2	349667	broad.mit.edu	37	11	57243961	57243961	+	Silent	SNP	C	C	G			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr11:57243961C>G	uc010rjt.1	+	3	840	c.840C>G	c.(838-840)CGC>CGG	p.R280R		NM_178570	NP_848665	Q86UN3	R4RL2_HUMAN	reticulon 4 receptor-like 2 precursor	280	LRRCT.				axon regeneration	anchored to plasma membrane	receptor activity				0						AGCGCGCGCGCGTGTCCAGCT	0.716		NaN											0	0	0	0.001168	0	5	4									
MS4A14	84689	broad.mit.edu	37	11	60183468	60183468	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr11:60183468C>T	uc001npj.2	+	5	1592	c.1027C>T	c.(1027-1029)CAT>TAT	p.H343Y	MS4A14_uc001npi.2_Missense_Mutation_p.H231Y|MS4A14_uc001npn.2_Missense_Mutation_p.H81Y|MS4A14_uc001npk.2_Missense_Mutation_p.H326Y|MS4A14_uc001npl.2_Missense_Mutation_p.H81Y|MS4A14_uc001npm.2_Missense_Mutation_p.H81Y	NM_032597	NP_115986	Q96JA4	M4A14_HUMAN	membrane-spanning 4-domains, subfamily A, member	343						integral to membrane	receptor activity			breast(1)	1						TACATCATCCCATGTCAAACA	0.338		NaN											0	0	0	0.006214	0	10	69									
VWCE	220001	broad.mit.edu	37	11	61058340	61058340	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr11:61058340G>C	uc001nra.2	-	4	634	c.355C>G	c.(355-357)CAG>GAG	p.Q119E	VWCE_uc001nrb.2_RNA	NM_152718	NP_689931	Q96DN2	VWCE_HUMAN	von Willebrand factor C and EGF domains	119						extracellular region	calcium ion binding			ovary(1)	1						GCCACCTCCTGACAGCCTCCA	0.622		NaN											0	0	0	0.006999	0	40	70									
TMEM179B	374395	broad.mit.edu	37	11	62557492	62557492	+	Silent	SNP	C	C	T			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr11:62557492C>T	uc001nvd.3	+	5	663	c.633C>T	c.(631-633)CTC>CTT	p.L211L		NM_199337	NP_955369	Q7Z7N9	T179B_HUMAN	transmembrane protein 179B	211						integral to membrane					0						CAGATGCTCTCGTTGGGTCAC	0.592		NaN											0	0	0	0.00361	0	64	107									
FAU	2197	broad.mit.edu	37	11	64889086	64889086	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr11:64889086G>A	uc001ocx.2	-	3	213	c.106C>T	c.(106-108)CCG>TCG	p.P36S	FAU_uc001ocy.1_Missense_Mutation_p.P36S|MRPL49_uc001ocz.1_5'Flank|MRPL49_uc001oda.1_5'Flank	NM_001997	NP_001988	P35544	UBIM_HUMAN	ubiquitin-like protein fubi and ribosomal	36											0						TGATCTTCCGGGGCAATGCCC	0.612		NaN											0	0	0	0.00308	0	8	116									
EHBP1L1	254102	broad.mit.edu	37	11	65349507	65349507	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr11:65349507C>T	uc001oeo.3	+	9	1629	c.1364C>T	c.(1363-1365)CCT>CTT	p.P455L	EHBP1L1_uc001oep.1_Intron	NM_001099409	NP_001092879	Q8N3D4	EH1L1_HUMAN	tangerin	455										central_nervous_system(1)	1						AGGGGGACCCCTGAGGCTCCT	0.642		NaN											0	0	0	0.00278	0	19	81									
NPAS4	266743	broad.mit.edu	37	11	66189921	66189921	+	Splice_Site	SNP	G	G	A			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr11:66189921G>A	uc001ohx.1	+	3	504	c.328_splice	c.e3-1	p.V110_splice	NPAS4_uc010rpc.1_Splice_Site	NM_178864	NP_849195	Q8IUM7	NPAS4_HUMAN	neuronal PAS domain protein 4						transcription, DNA-dependent		DNA binding|signal transducer activity				0						CCTCCCTCCAGGTGGACCTGG	0.527		NaN											0	0	0	0.00361	0	63	206									
ACTN3	89	broad.mit.edu	37	11	66325335	66325335	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr11:66325335C>G	uc001oio.1	+	10	1081	c.1063C>G	c.(1063-1065)CTG>GTG	p.L355V	ACTN3_uc010rpi.1_RNA	NM_001104	NP_001095	Q08043	ACTN3_HUMAN	actinin, alpha 3	355	Spectrin 1.				focal adhesion assembly|muscle filament sliding|regulation of apoptosis	actin filament|cytosol|focal adhesion|pseudopodium	actin binding|calcium ion binding|integrin binding|protein homodimerization activity|structural constituent of muscle				0						CTTCAACACACTGCAGACCAA	0.587		NaN											0	0	0	0.001168	0	5	102									
CCDC87	55231	broad.mit.edu	37	11	66359149	66359149	+	Silent	SNP	T	T	A			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr11:66359149T>A	uc001oiq.3	-	1	1406	c.1338A>T	c.(1336-1338)GTA>GTT	p.V446V	CCS_uc001oir.2_5'Flank	NM_018219	NP_060689	Q9NVE4	CCD87_HUMAN	coiled-coil domain containing 87	446										ovary(1)|skin(1)	2						CAGAGACCCGTACGGCAGCCG	0.532		NaN											0	0	0	0.004007	0	16	265									
PITPNM1	9600	broad.mit.edu	37	11	67269467	67269467	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr11:67269467C>T	uc001olx.2	-	4	695	c.506G>A	c.(505-507)CGA>CAA	p.R169Q	PITPNM1_uc001oly.2_Missense_Mutation_p.R169Q|PITPNM1_uc001olz.2_Missense_Mutation_p.R169Q	NM_004910	NP_004901	O00562	PITM1_HUMAN	phosphatidylinositol transfer protein,	169					brain development|lipid metabolic process|phototransduction|protein transport	cleavage furrow|endoplasmic reticulum membrane|Golgi cisterna membrane|lipid particle|membrane fraction|midbody	metal ion binding|phosphatidylinositol transporter activity	p.R169R(1)		lung(2)|central_nervous_system(1)	3						CAGTGGCCCTCGGCCCGTCTT	0.612		NaN											0	0	0	0.006999	0	38	85									
PITPNM1	9600	broad.mit.edu	37	11	67269826	67269826	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr11:67269826C>T	uc001olx.2	-	3	541	c.352G>A	c.(352-354)GAT>AAT	p.D118N	PITPNM1_uc001oly.2_Missense_Mutation_p.D118N|PITPNM1_uc001olz.2_Missense_Mutation_p.D118N	NM_004910	NP_004901	O00562	PITM1_HUMAN	phosphatidylinositol transfer protein,	118					brain development|lipid metabolic process|phototransduction|protein transport	cleavage furrow|endoplasmic reticulum membrane|Golgi cisterna membrane|lipid particle|membrane fraction|midbody	metal ion binding|phosphatidylinositol transporter activity			lung(2)|central_nervous_system(1)	3						TGCCCCCCATCAGGCAGGTAA	0.607		NaN											0	0	0	0.00361	0	68	199									
IGHMBP2	3508	broad.mit.edu	37	11	68703726	68703726	+	Missense_Mutation	SNP	A	A	G			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr11:68703726A>G	uc001ook.1	+	13	1880	c.1778A>G	c.(1777-1779)GAG>GGG	p.E593G	IGHMBP2_uc001ool.1_Missense_Mutation_p.E217G|IGHMBP2_uc001oom.1_Missense_Mutation_p.E171G	NM_002180	NP_002171	P38935	SMBP2_HUMAN	immunoglobulin mu binding protein 2	593					cell death|DNA recombination|DNA repair|DNA replication|protein homooligomerization|transcription, DNA-dependent|translation	axon|growth cone|nucleus|ribonucleoprotein complex	ATP binding|ATP-dependent 5'-3' DNA helicase activity|ATP-dependent 5'-3' RNA helicase activity|ribosome binding|single-stranded DNA binding|transcription factor binding|tRNA binding|zinc ion binding				0			STAD - Stomach adenocarcinoma(18;0.0208)|LUAD - Lung adenocarcinoma(13;0.0713)			TTTCTTGCTGAGGACCGGAGG	0.532		NaN											0	0	0	0.010818	0	33	410									
GRM5	2915	broad.mit.edu	37	11	88386506	88386506	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr11:88386506G>C	uc001pcq.2	-	3	1177	c.977C>G	c.(976-978)ACA>AGA	p.T326R	GRM5_uc009yvm.2_Missense_Mutation_p.T326R	NM_001143831	NP_001137303	P41594	GRM5_HUMAN	glutamate receptor, metabotropic 5 isoform a	326	Extracellular (Potential).				activation of phospholipase C activity by metabotropic glutamate receptor signaling pathway|synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			central_nervous_system(4)|ovary(2)|lung(2)|breast(1)	9		Acute lymphoblastic leukemia(157;2.54e-05)|all_hematologic(158;0.00834)			Acamprosate(DB00659)	GAGCTTGATTGTGATGCCACC	0.453		NaN											0	0	0	0.010729	0	11	74									
AMOTL1	154810	broad.mit.edu	37	11	94533301	94533301	+	Missense_Mutation	SNP	C	C	A			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr11:94533301C>A	uc001pfb.2	+	3	1115	c.945C>A	c.(943-945)TTC>TTA	p.F315L	AMOTL1_uc001pfc.2_Missense_Mutation_p.F265L	NM_130847	NP_570899	Q8IY63	AMOL1_HUMAN	angiomotin like 1	315						cytoplasm|tight junction	identical protein binding			ovary(1)|breast(1)	2		Acute lymphoblastic leukemia(157;2.38e-05)|all_hematologic(158;0.00824)				AGTACCCCTTCAAGACCAAGC	0.597		NaN											1	0	2.21704e-12	0.00278	2.45088e-12	24	165									
BTG4	54766	broad.mit.edu	37	11	111369384	111369384	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr11:111369384C>G	uc001plj.2	-	2	303	c.118G>C	c.(118-120)GAA>CAA	p.E40Q	BTG4_uc001plk.2_Missense_Mutation_p.E40Q	NM_017589	NP_060059	Q9NY30	BTG4_HUMAN	B-cell translocation gene 4	40					cell cycle arrest|negative regulation of cell proliferation|neuron differentiation						0		all_cancers(61;3.78e-13)|all_epithelial(67;5.29e-08)|Melanoma(852;3.15e-06)|all_hematologic(158;0.000405)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0204)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		Epithelial(105;1.22e-06)|BRCA - Breast invasive adenocarcinoma(274;1.72e-06)|all cancers(92;2.18e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.0509)		CTGTATGTTTCAAACAAGATC	0.408		NaN											0	0	0	0.004656	0	28	10									
GRAMD1B	57476	broad.mit.edu	37	11	123483472	123483472	+	Silent	SNP	C	C	G			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr11:123483472C>G	uc001pyx.2	+	14	1823	c.1494C>G	c.(1492-1494)GTC>GTG	p.V498V	GRAMD1B_uc001pyw.2_Silent_p.V505V|GRAMD1B_uc010rzw.1_Silent_p.V458V|GRAMD1B_uc010rzx.1_Silent_p.V458V|GRAMD1B_uc001pyy.2_Silent_p.V189V	NM_020716	NP_065767	Q3KR37	GRM1B_HUMAN	GRAM domain containing 1B	498						integral to membrane				ovary(1)	1		Breast(109;0.00204)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.32e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0394)		TCCTCAGGGTCTCCACAGAGC	0.522		NaN											0	0	0	0.00499	0	16	6									
ROBO3	64221	broad.mit.edu	37	11	124747869	124747869	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr11:124747869G>A	uc001qbc.2	+	21	3215	c.3023G>A	c.(3022-3024)AGG>AAG	p.R1008K	ROBO3_uc010saq.1_3'UTR|ROBO3_uc001qbd.2_5'UTR|ROBO3_uc010sar.1_Missense_Mutation_p.R57K|ROBO3_uc001qbe.2_5'UTR|ROBO3_uc001qbf.1_5'UTR	NM_022370	NP_071765	Q96MS0	ROBO3_HUMAN	roundabout, axon guidance receptor, homolog 3	1008	Cytoplasmic (Potential).				axon midline choice point recognition	integral to membrane	receptor activity			breast(1)|central_nervous_system(1)	2	all_hematologic(175;0.215)	Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|Breast(109;0.0481)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.5e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0296)		CAGACGGCCAGGGGCACGGCC	0.597		NaN											0	0	0	0.004672	0	3	17									
SLC6A12	6539	broad.mit.edu	37	12	306659	306659	+	Missense_Mutation	SNP	A	A	C			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr12:306659A>C	uc001qhz.2	-	11	1502	c.959T>G	c.(958-960)ATC>AGC	p.I320S	SLC6A12_uc001qhx.2_5'UTR|SLC6A12_uc001qhy.2_5'UTR|SLC6A12_uc001qia.2_Missense_Mutation_p.I320S|SLC6A12_uc001qib.2_Missense_Mutation_p.I320S|SLC6A12_uc009zdh.1_Missense_Mutation_p.I320S	NM_003044	NP_003035	P48065	S6A12_HUMAN	solute carrier family 6 (neurotransmitter	320	Helical; Name=7; (Potential).				cellular nitrogen compound metabolic process|neurotransmitter secretion	integral to plasma membrane	gamma-aminobutyric acid:sodium symporter activity|neurotransmitter:sodium symporter activity			ovary(1)	1	all_cancers(10;0.0172)|all_epithelial(11;0.0283)|all_lung(10;0.0392)|Lung NSC(10;0.0567)|Ovarian(42;0.142)		OV - Ovarian serous cystadenocarcinoma(31;0.00227)			GCAGAGGGCGATGCAGTCCCT	0.378		NaN											0	0	0	0.000602	0	4	36									
CCDC77	84318	broad.mit.edu	37	12	550970	550970	+	Missense_Mutation	SNP	C	C	A			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr12:550970C>A	uc001qig.2	+	13	1531	c.1351C>A	c.(1351-1353)CTT>ATT	p.L451I	CCDC77_uc009zdk.2_Missense_Mutation_p.L419I|CCDC77_uc010sdp.1_Missense_Mutation_p.L419I|CCDC77_uc010sdq.1_Missense_Mutation_p.L419I	NM_032358	NP_115734	Q9BR77	CCD77_HUMAN	coiled-coil domain containing 77 isoform a	451	Potential.					centrosome				ovary(1)	1	all_cancers(10;0.0149)|all_epithelial(11;0.035)|all_lung(10;0.111)|Ovarian(42;0.142)|Lung NSC(10;0.156)		OV - Ovarian serous cystadenocarcinoma(31;0.00123)|BRCA - Breast invasive adenocarcinoma(9;0.033)			AAACCAGGATCTTGCCCTTCT	0.433		NaN											1	0	7.03913e-09	0.001368	7.59668e-09	13	116									
WNK1	65125	broad.mit.edu	37	12	994879	994879	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr12:994879G>A	uc001qio.3	+	19	5416	c.4909G>A	c.(4909-4911)GAA>AAA	p.E1637K	WNK1_uc001qip.3_Missense_Mutation_p.E1390K|WNK1_uc001qir.3_Missense_Mutation_p.E810K	NM_018979	NP_061852	Q9H4A3	WNK1_HUMAN	WNK lysine deficient protein kinase 1	1637					intracellular protein kinase cascade|ion transport|neuron development	cytoplasm	ATP binding|protein binding|protein kinase inhibitor activity|protein serine/threonine kinase activity			stomach(6)|breast(6)|ovary(5)|lung(4)|large_intestine(1)|central_nervous_system(1)	23	all_cancers(10;0.00611)|all_epithelial(11;0.00825)|all_lung(10;0.0331)|Ovarian(42;0.0512)|Lung NSC(10;0.0632)		Epithelial(1;1.74e-08)|all cancers(1;7.04e-08)|OV - Ovarian serous cystadenocarcinoma(31;0.000423)|BRCA - Breast invasive adenocarcinoma(9;0.0149)|Colorectal(1;0.0197)			TCATTGTCCTGAAGTAGATTC	0.473		NaN											0	0	0	0.00361	0	71	68									
WNK1	65125	broad.mit.edu	37	12	994963	994963	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr12:994963G>A	uc001qio.3	+	19	5500	c.4993G>A	c.(4993-4995)GAA>AAA	p.E1665K	WNK1_uc001qip.3_Missense_Mutation_p.E1418K|WNK1_uc001qir.3_Missense_Mutation_p.E838K	NM_018979	NP_061852	Q9H4A3	WNK1_HUMAN	WNK lysine deficient protein kinase 1	1665					intracellular protein kinase cascade|ion transport|neuron development	cytoplasm	ATP binding|protein binding|protein kinase inhibitor activity|protein serine/threonine kinase activity			stomach(6)|breast(6)|ovary(5)|lung(4)|large_intestine(1)|central_nervous_system(1)	23	all_cancers(10;0.00611)|all_epithelial(11;0.00825)|all_lung(10;0.0331)|Ovarian(42;0.0512)|Lung NSC(10;0.0632)		Epithelial(1;1.74e-08)|all cancers(1;7.04e-08)|OV - Ovarian serous cystadenocarcinoma(31;0.000423)|BRCA - Breast invasive adenocarcinoma(9;0.0149)|Colorectal(1;0.0197)			TCTGTTCAGTGAACACAGCTC	0.478		NaN											0	0	0	0.00361	0	57	53									
DYRK4	8798	broad.mit.edu	37	12	4722735	4722735	+	Missense_Mutation	SNP	T	T	C			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr12:4722735T>C	uc001qmx.2	+	13	1539	c.1379T>C	c.(1378-1380)GTT>GCT	p.V460A	DYRK4_uc001qmy.1_Missense_Mutation_p.V459A|DYRK4_uc001qmz.1_Missense_Mutation_p.V173A|DYRK4_uc001qna.1_Missense_Mutation_p.V96A|DYRK4_uc010ser.1_Missense_Mutation_p.V97A	NM_003845	NP_003836	Q9NR20	DYRK4_HUMAN	dual-specificity tyrosine-(Y)-phosphorylation	460						Golgi apparatus	ATP binding|metal ion binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			lung(2)|skin(1)	3			Colorectal(7;0.103)			ACGAAGCATGTTCAGCATTCA	0.493		NaN											0	0	0	0.008291	0	10	89									
GRIN2B	2904	broad.mit.edu	37	12	13717440	13717440	+	Missense_Mutation	SNP	A	A	C			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr12:13717440A>C	uc001rbt.2	-	13	2911	c.2732T>G	c.(2731-2733)CTG>CGG	p.L911R		NM_000834	NP_000825	Q13224	NMDE2_HUMAN	N-methyl-D-aspartate receptor subunit 2B	911	Cytoplasmic (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	glycine binding|N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			central_nervous_system(4)|ovary(3)|skin(3)|lung(2)	12					Felbamate(DB00949)|Haloperidol(DB00502)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	CACACCAGACAGGTTAGCCAT	0.582		NaN											0	0	0	0.00361	0	65	270									
SOX5	6660	broad.mit.edu	37	12	23999053	23999053	+	Missense_Mutation	SNP	T	T	A			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr12:23999053T>A	uc001rfw.2	-	3	447	c.345A>T	c.(343-345)GAA>GAT	p.E115D	SOX5_uc001rfx.2_Missense_Mutation_p.E102D|SOX5_uc001rfy.2_Missense_Mutation_p.E102D|SOX5_uc010siv.1_Missense_Mutation_p.E102D|SOX5_uc010siw.1_RNA|SOX5_uc001rfz.1_Missense_Mutation_p.E67D|SOX5_uc001rga.2_Missense_Mutation_p.E80D	NM_006940	NP_008871	P35711	SOX5_HUMAN	SRY (sex determining region Y)-box 5 isoform a	115					transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(5)|lung(1)	6						GTCGCCCACCTTCTTCTGCCT	0.478		NaN											0	0	0	0.00245	0	13	155									
MLL2	8085	broad.mit.edu	37	12	49431524	49431525	+	Missense_Mutation	DNP	TC	TC	CA			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08			TC	CA	TC	TC		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr12:49431524_49431525TC>CA	uc001rta.3	-	34	9614_9615	c.9614_9615GA>TG	c.(9613-9615)GGA>GTG	p.G3205V		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	3205					chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						GGGAGGATCCTCCTGGGCCACT	0.599		NaN	N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			0	0	0	0.004672	0	4	21									
ERBB3	2065	broad.mit.edu	37	12	56480394	56480394	+	Silent	SNP	G	G	C			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr12:56480394G>C	uc001sjh.2	+	4	694	c.501G>C	c.(499-501)GTG>GTC	p.V167V	ERBB3_uc009zoj.2_RNA|ERBB3_uc010sqb.1_Intron|ERBB3_uc010sqc.1_Silent_p.V108V|ERBB3_uc001sji.2_5'Flank	NM_001982	NP_001973	P21860	ERBB3_HUMAN	erbB-3 isoform 1 precursor	167	Extracellular (Potential).				cranial nerve development|heart development|negative regulation of cell adhesion|negative regulation of neuron apoptosis|negative regulation of secretion|negative regulation of signal transduction|neuron apoptosis|phosphatidylinositol 3-kinase cascade|positive regulation of phosphatidylinositol 3-kinase cascade|regulation of cell proliferation|Schwann cell differentiation|transmembrane receptor protein tyrosine kinase signaling pathway|wound healing	basolateral plasma membrane|extracellular space|integral to plasma membrane|receptor complex	ATP binding|growth factor binding|protein heterodimerization activity|protein homodimerization activity|protein tyrosine kinase activator activity|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			lung(3)|central_nervous_system(2)|stomach(1)|ovary(1)|skin(1)	8			OV - Ovarian serous cystadenocarcinoma(18;0.112)			GGGACATCGTGAGGGACCGAG	0.493		NaN											0	0	0	0.012213	0	30	254									
NAB2	4665	broad.mit.edu	37	12	57485446	57485446	+	Missense_Mutation	SNP	T	T	C			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr12:57485446T>C	uc001smz.2	+	2	1000	c.622T>C	c.(622-624)TTC>CTC	p.F208L		NM_005967	NP_005958	Q15742	NAB2_HUMAN	NGFI-A binding protein 2	208					cell proliferation|negative regulation of transcription from RNA polymerase III promoter|transcription, DNA-dependent	nucleus	transcription corepressor activity			upper_aerodigestive_tract(1)|ovary(1)	2						CTCGCCCCCCTTCTCCCCCCC	0.716		NaN											0	0	0	0.008871	0	7	51									
PIP4K2C	79837	broad.mit.edu	37	12	57985171	57985171	+	Silent	SNP	C	C	T			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr12:57985171C>T	uc001sou.2	+	1	230	c.99C>T	c.(97-99)TTC>TTT	p.F33F	PIP4K2C_uc001sot.2_Silent_p.F33F|PIP4K2C_uc010srs.1_Silent_p.F33F|PIP4K2C_uc010srt.1_Silent_p.F33F	NM_001146258	NP_001139730	Q8TBX8	PI42C_HUMAN	phosphatidylinositol-5-phosphate 4-kinase, type	33						cytoplasm|membrane	1-phosphatidylinositol-5-phosphate 4-kinase activity|ATP binding|identical protein binding			central_nervous_system(2)|lung(1)	3	Melanoma(17;0.122)					AGAAGCATTTCGTGCAGCAGA	0.662		NaN											0	0	0	0.00361	0	101	258									
IRAK3	11213	broad.mit.edu	37	12	66639035	66639035	+	Missense_Mutation	SNP	T	T	C			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr12:66639035T>C	uc001sth.2	+	11	1409	c.1307T>C	c.(1306-1308)ATG>ACG	p.M436T	IRAK3_uc010ssy.1_Missense_Mutation_p.M375T	NM_007199	NP_009130	Q9Y616	IRAK3_HUMAN	interleukin-1 receptor-associated kinase 3	436	Protein kinase.				interleukin-1-mediated signaling pathway|MyD88-dependent toll-like receptor signaling pathway|negative regulation of innate immune response|negative regulation of interleukin-12 production|negative regulation of interleukin-6 production|negative regulation of macrophage cytokine production|negative regulation of MAP kinase activity|negative regulation of NF-kappaB transcription factor activity|negative regulation of protein catabolic process|negative regulation of protein complex disassembly|negative regulation of toll-like receptor signaling pathway|negative regulation of tumor necrosis factor production|positive regulation of macrophage tolerance induction|positive regulation of NF-kappaB transcription factor activity|response to exogenous dsRNA|response to lipopolysaccharide|response to peptidoglycan	cytoplasm|nucleus	ATP binding|magnesium ion binding|protein heterodimerization activity|protein homodimerization activity|protein serine/threonine kinase activity			lung(3)|ovary(2)|breast(2)|central_nervous_system(1)	8				GBM - Glioblastoma multiforme(28;0.0203)		AGACCATCAATGGATGAAGTG	0.418		NaN											0	0	0	0.00361	0	77	372									
IFNG	3458	broad.mit.edu	37	12	68553296	68553296	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr12:68553296G>C	uc001stw.1	-	1	226	c.100C>G	c.(100-102)CTT>GTT	p.L34V		NM_000619	NP_000610	P01579	IFNG_HUMAN	interferon, gamma precursor	34					cell cycle arrest|interferon-gamma-mediated signaling pathway|negative regulation of interleukin-17 production|negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis|negative regulation of metanephric nephron tubule epithelial cell differentiation|negative regulation of smooth muscle cell proliferation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of calcidiol 1-monooxygenase activity|positive regulation of fructose 1,6-bisphosphate 1-phosphatase activity|positive regulation of fructose 1,6-bisphosphate metabolic process|positive regulation of interleukin-12 production|positive regulation of interleukin-23 production|positive regulation of killing of cells of other organism|positive regulation of membrane protein ectodomain proteolysis|positive regulation of mesenchymal cell proliferation|positive regulation of nitric oxide biosynthetic process|positive regulation of osteoclast differentiation|positive regulation of peptidyl-serine phosphorylation of STAT protein|positive regulation of smooth muscle cell apoptosis|positive regulation of tumor necrosis factor (ligand) superfamily member 11 production|positive regulation of tyrosine phosphorylation of Stat1 protein|positive regulation of vitamin D biosynthetic process|protein import into nucleus, translocation|regulation of insulin secretion|regulation of interferon-gamma-mediated signaling pathway|response to virus	extracellular space	cytokine activity|interferon-gamma receptor binding				0			Lung(24;0.000131)|LUAD - Lung adenocarcinoma(15;0.00107)|STAD - Stomach adenocarcinoma(21;0.018)	GBM - Glioblastoma multiforme(7;0.000829)	Glucosamine(DB01296)|Interferon gamma-1b(DB00033)|Simvastatin(DB00641)	TATTTCTTAAGGTTTTCTGCT	0.363		NaN											0	0	0	0.000602	0	5	51									
CORO1C	23603	broad.mit.edu	37	12	109095064	109095064	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr12:109095064G>A	uc001tnj.2	-	2	127	c.31C>T	c.(31-33)CGG>TGG	p.R11W	CORO1C_uc009zva.2_Missense_Mutation_p.R64W|CORO1C_uc010sxf.1_Missense_Mutation_p.R11W	NM_014325	NP_055140	Q9ULV4	COR1C_HUMAN	coronin, actin binding protein, 1C isoform 1	11					actin cytoskeleton organization|phagocytosis|signal transduction	actin cytoskeleton	actin filament binding			skin(3)	3						AATACATGCCGAAACTTGCTC	0.443		NaN											0	0	0	0.010729	0	10	165									
KNTC1	9735	broad.mit.edu	37	12	123072359	123072359	+	Missense_Mutation	SNP	T	T	G			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr12:123072359T>G	uc001ucv.2	+	39	3995	c.3832T>G	c.(3832-3834)TCA>GCA	p.S1278A	KNTC1_uc010taf.1_Intron	NM_014708	NP_055523	P50748	KNTC1_HUMAN	Rough Deal homolog, centromere/kinetochore	1278					cell division|mitotic cell cycle checkpoint|mitotic prometaphase|protein complex assembly|regulation of exit from mitosis	condensed chromosome kinetochore|cytosol|kinetochore microtubule|nucleus|spindle pole	protein binding			ovary(5)|kidney(3)|lung(1)|central_nervous_system(1)	10	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;7.21e-05)|Epithelial(86;0.000178)|BRCA - Breast invasive adenocarcinoma(302;0.217)		TGTGGTTGGTTCATTTGGTAC	0.423		NaN											0	0	0	0.009096	0	3	37									
KNTC1	9735	broad.mit.edu	37	12	123078909	123078909	+	Silent	SNP	A	A	C			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr12:123078909A>C	uc001ucv.2	+	43	4495	c.4332A>C	c.(4330-4332)ACA>ACC	p.T1444T	KNTC1_uc010taf.1_Intron	NM_014708	NP_055523	P50748	KNTC1_HUMAN	Rough Deal homolog, centromere/kinetochore	1444					cell division|mitotic cell cycle checkpoint|mitotic prometaphase|protein complex assembly|regulation of exit from mitosis	condensed chromosome kinetochore|cytosol|kinetochore microtubule|nucleus|spindle pole	protein binding			ovary(5)|kidney(3)|lung(1)|central_nervous_system(1)	10	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;7.21e-05)|Epithelial(86;0.000178)|BRCA - Breast invasive adenocarcinoma(302;0.217)		ATATGGACACAAGCCTCATTT	0.323		NaN											0	0	0	0.003954	0	24	42									
MPHOSPH9	10198	broad.mit.edu	37	12	123687540	123687540	+	Missense_Mutation	SNP	C	C	A			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr12:123687540C>A	uc001uel.2	-	6	1063	c.956G>T	c.(955-957)AGA>ATA	p.R319I	MPHOSPH9_uc010tal.1_Intron|MPHOSPH9_uc010tam.1_RNA|MPHOSPH9_uc001uem.2_Intron	NM_022782	NP_073619	Q99550	MPP9_HUMAN	M-phase phosphoprotein 9	319					M phase of mitotic cell cycle	centriole|Golgi membrane					0	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000182)|Epithelial(86;0.00046)|BRCA - Breast invasive adenocarcinoma(302;0.169)		AAAGGATATTCTGTCATCAAG	0.463		NaN											1	0	2.01807e-28	0.00361	2.31547e-28	52	177									
GTF2H3	2967	broad.mit.edu	37	12	124144458	124144458	+	Silent	SNP	C	C	A			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr12:124144458C>A	uc001ufo.1	+	11	827	c.801C>A	c.(799-801)GTC>GTA	p.V267V	GTF2H3_uc010tau.1_Silent_p.V226V	NM_001516	NP_001507	Q13889	TF2H3_HUMAN	general transcription factor IIH, polypeptide 3,	267					mRNA capping|nucleotide-excision repair, DNA damage removal|positive regulation of viral transcription|protein phosphorylation|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase I promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	core TFIIH complex|holo TFIIH complex	damaged DNA binding|metal ion binding|protein N-terminus binding|sequence-specific DNA binding transcription factor activity|translation factor activity, nucleic acid binding				0	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;7.1e-05)|Epithelial(86;0.000388)|all cancers(50;0.00362)		TTGGTTATGTCTGTTCTGTGT	0.403		NaN						NER					1	0	1.45844e-13	0.002836	1.62214e-13	35	62									
ULK1	8408	broad.mit.edu	37	12	132379547	132379547	+	Missense_Mutation	SNP	A	A	G			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr12:132379547A>G	uc001uje.2	+	1	269	c.1A>G	c.(1-3)ATG>GTG	p.M1V		NM_003565	NP_003556	O75385	ULK1_HUMAN	Unc-51-like kinase 1	1					autophagy|protein localization|regulation of autophagy	autophagic vacuole|cytosol|pre-autophagosomal structure|ULK1-ATG13-FIP200 complex	ATP binding|protein complex binding|protein serine/threonine kinase activity			ovary(1)|lung(1)|central_nervous_system(1)|skin(1)	4	all_neural(191;0.0982)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;2.07e-08)|Epithelial(86;2.56e-07)|all cancers(50;3.01e-07)		cgccTGCGCCATGGAGCCCGG	0.373		NaN											0	0	0	0.000602	0	4	7									
EP400	57634	broad.mit.edu	37	12	132504716	132504716	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr12:132504716G>A	uc001ujn.2	+	21	4435	c.4400G>A	c.(4399-4401)CGA>CAA	p.R1467Q	EP400_uc001ujl.2_Missense_Mutation_p.R1466Q|EP400_uc001ujm.2_Missense_Mutation_p.R1467Q	NM_015409	NP_056224	Q96L91	EP400_HUMAN	E1A binding protein p400	1503					histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nuclear speck	ATP binding|DNA binding|helicase activity			central_nervous_system(4)|ovary(3)|breast(3)|skin(2)	12	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.198)		OV - Ovarian serous cystadenocarcinoma(86;3.01e-08)|Epithelial(86;3.43e-07)|all cancers(50;2.01e-06)		GGCCCGCTTCGAGGACGGCCG	0.652		NaN											0	0	0	0.007291	0	27	94									
ATP12A	479	broad.mit.edu	37	13	25276099	25276099	+	Silent	SNP	C	C	A			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr13:25276099C>A	uc001upp.2	+	14	2095	c.1908C>A	c.(1906-1908)CCC>CCA	p.P636P	ATP12A_uc010aaa.2_Silent_p.P642P	NM_001676	NP_001667	P54707	AT12A_HUMAN	hydrogen/potassium-exchanging ATPase 12A	636	Cytoplasmic (Potential).				ATP biosynthetic process	hydrogen:potassium-exchanging ATPase complex	ATP binding|hydrogen:potassium-exchanging ATPase activity|metal ion binding			ovary(2)|central_nervous_system(2)|large_intestine(1)|breast(1)	6		Lung SC(185;0.0225)|Breast(139;0.077)		all cancers(112;0.0307)|Epithelial(112;0.086)|OV - Ovarian serous cystadenocarcinoma(117;0.228)	Esomeprazole(DB00736)|Pantoprazole(DB00213)	GTGATCATCCCATCACAGCCA	0.478		NaN											1	0	7.93312e-07	0.00245	8.33054e-07	13	154									
ATP12A	479	broad.mit.edu	37	13	25281419	25281419	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr13:25281419C>T	uc001upp.2	+	17	2528	c.2341C>T	c.(2341-2343)CGC>TGC	p.R781C	ATP12A_uc010aaa.2_Missense_Mutation_p.R787C	NM_001676	NP_001667	P54707	AT12A_HUMAN	hydrogen/potassium-exchanging ATPase 12A	781	Cytoplasmic (Potential).				ATP biosynthetic process	hydrogen:potassium-exchanging ATPase complex	ATP binding|hydrogen:potassium-exchanging ATPase activity|metal ion binding			ovary(2)|central_nervous_system(2)|large_intestine(1)|breast(1)	6		Lung SC(185;0.0225)|Breast(139;0.077)		all cancers(112;0.0307)|Epithelial(112;0.086)|OV - Ovarian serous cystadenocarcinoma(117;0.228)	Esomeprazole(DB00736)|Pantoprazole(DB00213)	CTGCCTAGGTCGCCTGATCTT	0.532		NaN											0	0	0	0.00361	0	52	130									
BRCA2	675	broad.mit.edu	37	13	32936814	32936814	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr13:32936814C>T	uc001uub.1	+	17	8187	c.7960C>T	c.(7960-7962)CTT>TTT	p.L2654F		NM_000059	NP_000050	P51587	BRCA2_HUMAN	breast cancer 2, early onset	2654					cell cycle cytokinesis|centrosome duplication|double-strand break repair via homologous recombination|negative regulation of mammary gland epithelial cell proliferation|nucleotide-excision repair|positive regulation of transcription, DNA-dependent|regulation of S phase of mitotic cell cycle	BRCA2-MAGE-D1 complex|centrosome|nucleoplasm|stored secretory granule	gamma-tubulin binding|H3 histone acetyltransferase activity|H4 histone acetyltransferase activity|protease binding|single-stranded DNA binding			ovary(20)|endometrium(8)|lung(7)|breast(7)|oesophagus(5)|large_intestine(4)|central_nervous_system(3)|pancreas(3)|skin(2)|upper_aerodigestive_tract(1)|cervix(1)|salivary_gland(1)|liver(1)|kidney(1)	64		Lung SC(185;0.0262)		all cancers(112;7.13e-07)|Epithelial(112;1.59e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.000732)|BRCA - Breast invasive adenocarcinoma(63;0.0291)|GBM - Glioblastoma multiforme(144;0.0704)		AAGGGTGCTTCTTCAACTAAA	0.373		NaN	D|Mis|N|F|S		breast|ovarian|pancreatic	breast|ovarian|pancreatic|leukemia  (FANCB|FANCD1)		Direct_reversal_of_damage|Homologous_recombination	Fanconi_Anemia_type_D1_bi-allelic_BRCA2_mutations|Fanconi_Anemia|Pancreatic_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_BRCA2_type|Hereditary_Prostate_Cancer|Li-Fraumeni_syndrome	TCGA Ovarian(8;0.087)			0	0	0	0.00333	0	22	25									
BRCA2	675	broad.mit.edu	37	13	32936817	32936817	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr13:32936817C>T	uc001uub.1	+	17	8190	c.7963C>T	c.(7963-7965)CAA>TAA	p.Q2655*		NM_000059	NP_000050	P51587	BRCA2_HUMAN	breast cancer 2, early onset	2655					cell cycle cytokinesis|centrosome duplication|double-strand break repair via homologous recombination|negative regulation of mammary gland epithelial cell proliferation|nucleotide-excision repair|positive regulation of transcription, DNA-dependent|regulation of S phase of mitotic cell cycle	BRCA2-MAGE-D1 complex|centrosome|nucleoplasm|stored secretory granule	gamma-tubulin binding|H3 histone acetyltransferase activity|H4 histone acetyltransferase activity|protease binding|single-stranded DNA binding			ovary(20)|endometrium(8)|lung(7)|breast(7)|oesophagus(5)|large_intestine(4)|central_nervous_system(3)|pancreas(3)|skin(2)|upper_aerodigestive_tract(1)|cervix(1)|salivary_gland(1)|liver(1)|kidney(1)	64		Lung SC(185;0.0262)		all cancers(112;7.13e-07)|Epithelial(112;1.59e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.000732)|BRCA - Breast invasive adenocarcinoma(63;0.0291)|GBM - Glioblastoma multiforme(144;0.0704)		GGTGCTTCTTCAACTAAAATA	0.378		NaN	D|Mis|N|F|S		breast|ovarian|pancreatic	breast|ovarian|pancreatic|leukemia  (FANCB|FANCD1)		Direct_reversal_of_damage|Homologous_recombination	Fanconi_Anemia_type_D1_bi-allelic_BRCA2_mutations|Fanconi_Anemia|Pancreatic_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_BRCA2_type|Hereditary_Prostate_Cancer|Li-Fraumeni_syndrome	TCGA Ovarian(8;0.087)			0	0	0	0.00333	0	22	25									
BRCA2	675	broad.mit.edu	37	13	32937596	32937596	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr13:32937596C>T	uc001uub.1	+	18	8484	c.8257C>T	c.(8257-8259)CTT>TTT	p.L2753F		NM_000059	NP_000050	P51587	BRCA2_HUMAN	breast cancer 2, early onset	2753					cell cycle cytokinesis|centrosome duplication|double-strand break repair via homologous recombination|negative regulation of mammary gland epithelial cell proliferation|nucleotide-excision repair|positive regulation of transcription, DNA-dependent|regulation of S phase of mitotic cell cycle	BRCA2-MAGE-D1 complex|centrosome|nucleoplasm|stored secretory granule	gamma-tubulin binding|H3 histone acetyltransferase activity|H4 histone acetyltransferase activity|protease binding|single-stranded DNA binding			ovary(20)|endometrium(8)|lung(7)|breast(7)|oesophagus(5)|large_intestine(4)|central_nervous_system(3)|pancreas(3)|skin(2)|upper_aerodigestive_tract(1)|cervix(1)|salivary_gland(1)|liver(1)|kidney(1)	64		Lung SC(185;0.0262)		all cancers(112;7.13e-07)|Epithelial(112;1.59e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.000732)|BRCA - Breast invasive adenocarcinoma(63;0.0291)|GBM - Glioblastoma multiforme(144;0.0704)		GAAGATTATTCTTCATGGAGC	0.438		NaN	D|Mis|N|F|S		breast|ovarian|pancreatic	breast|ovarian|pancreatic|leukemia  (FANCB|FANCD1)		Direct_reversal_of_damage|Homologous_recombination	Fanconi_Anemia_type_D1_bi-allelic_BRCA2_mutations|Fanconi_Anemia|Pancreatic_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_BRCA2_type|Hereditary_Prostate_Cancer|Li-Fraumeni_syndrome	TCGA Ovarian(8;0.087)			0	0	0	0.012319	0	21	65									
KLF5	688	broad.mit.edu	37	13	73636804	73636804	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08			C	G	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr13:73636804C>G	uc001vje.2	+	2	1391	c.1067C>G	c.(1066-1068)CCT>CGT	p.P356R	KLF5_uc001vjd.2_Missense_Mutation_p.P265R	NM_001730	NP_001721	Q13887	KLF5_HUMAN	Kruppel-like factor 5	356					transcription from RNA polymerase II promoter	nucleus	DNA binding|zinc ion binding			large_intestine(1)|ovary(1)|pancreas(1)	3		Prostate(6;0.00187)|Breast(118;0.0735)		GBM - Glioblastoma multiforme(99;0.0011)		AACATCCAACCTGTCAGATAC	0.453		NaN											0	0	0	0.007413	0	18	89									
DCT	1638	broad.mit.edu	37	13	95121217	95121217	+	Missense_Mutation	SNP	A	A	C			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr13:95121217A>C	uc001vlv.3	-	2	805	c.378T>G	c.(376-378)ATT>ATG	p.I126M	DCT_uc010afh.2_Missense_Mutation_p.I126M	NM_001922	NP_001913	P40126	TYRP2_HUMAN	dopachrome tautomerase isoform 1	126	Lumenal, melanosome (Potential).				epidermis development|melanin biosynthetic process from tyrosine	cytosol|integral to membrane|melanosome membrane|microsome	copper ion binding|dopachrome isomerase activity|oxidoreductase activity			ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	5	all_neural(89;0.0684)|Medulloblastoma(90;0.163)	all_cancers(2;3.71e-42)|all_epithelial(2;3.76e-31)|all_lung(2;5.16e-14)|Lung NSC(4;1.33e-13)|Breast(118;0.0013)|Hepatocellular(115;0.00886)|Renal(2;0.00988)		COAD - Colon adenocarcinoma(199;7.07e-05)|GBM - Glioblastoma multiforme(99;0.000472)		TGTTCTGCCGAATCACTGGTG	0.507		NaN											0	0	0	0.00361	0	94	202									
RASA3	22821	broad.mit.edu	37	13	114778667	114778667	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr13:114778667G>A	uc001vui.2	-	15	1594	c.1463C>T	c.(1462-1464)GCG>GTG	p.A488V	RASA3_uc010tkk.1_Missense_Mutation_p.A456V|RASA3_uc001vuj.2_Missense_Mutation_p.A105V	NM_007368	NP_031394	Q14644	RASA3_HUMAN	RAS p21 protein activator 3	488	Ras-GAP.				intracellular signal transduction|negative regulation of Ras protein signal transduction	cytoplasm|intrinsic to internal side of plasma membrane	calcium-release channel activity|metal ion binding|Ras GTPase activator activity			lung(3)|skin(1)	4	Lung NSC(43;0.00814)|all_neural(89;0.0337)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.016)|all_epithelial(44;0.00577)|all_lung(25;0.0173)|Lung NSC(25;0.0634)|Breast(118;0.188)	BRCA - Breast invasive adenocarcinoma(86;0.128)			AATGGCGGGCGCAAAGAACCT	0.617		NaN											0	0	0	0.003954	0	18	6									
OR4Q3	441669	broad.mit.edu	37	14	20215775	20215775	+	Silent	SNP	T	T	C			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr14:20215775T>C	uc010tkt.1	+	1	189	c.189T>C	c.(187-189)TTT>TTC	p.F63F		NM_172194	NP_751944	Q8NH05	OR4Q3_HUMAN	olfactory receptor, family 4, subfamily Q,	63	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(3)	3	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		TGTATTATTTTTTAGGTCATC	0.413		NaN											0	0	0	0.00361	0	59	143									
ACIN1	22985	broad.mit.edu	37	14	23533347	23533347	+	Missense_Mutation	SNP	G	G	T			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr14:23533347G>T	uc001wit.3	-	12	3064	c.2736C>A	c.(2734-2736)GAC>GAA	p.D912E	ACIN1_uc001wio.3_RNA|ACIN1_uc001wip.3_Missense_Mutation_p.D154E|ACIN1_uc001wiq.3_Missense_Mutation_p.D154E|ACIN1_uc001wir.3_Missense_Mutation_p.D185E|ACIN1_uc001wis.3_Missense_Mutation_p.D593E|ACIN1_uc010akg.2_Missense_Mutation_p.D899E	NM_014977	NP_055792	Q9UKV3	ACINU_HUMAN	apoptotic chromatin condensation inducer 1	912					apoptotic chromosome condensation|erythrocyte differentiation|positive regulation of monocyte differentiation	cytosol	ATPase activity|enzyme binding|nucleic acid binding|nucleotide binding			ovary(2)|large_intestine(1)|skin(1)	4	all_cancers(95;1.36e-05)			GBM - Glioblastoma multiforme(265;0.00816)		TCAGCCCCTTGTCATGGGTCC	0.562		NaN											1	0	1.58986e-06	0.008291	1.6631e-06	11	170									
EFS	10278	broad.mit.edu	37	14	23829056	23829056	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr14:23829056C>T	uc001wjo.2	-	4	1239	c.631G>A	c.(631-633)GAG>AAG	p.E211K	EFS_uc001wjp.2_Missense_Mutation_p.E118K|EFS_uc010tnm.1_Intron	NM_005864	NP_005855	O43281	EFS_HUMAN	embryonal Fyn-associated substrate isoform 1	211	Pro-rich.				cell adhesion|intracellular signal transduction	cytoplasm	SH3 domain binding			large_intestine(1)	1	all_cancers(95;7.12e-06)			GBM - Glioblastoma multiforme(265;0.00649)		GGCCCCGGCTCCCGGCCTCCT	0.617		NaN											0	0	0	0.010818	0	31	137									
JPH4	84502	broad.mit.edu	37	14	24045009	24045009	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr14:24045009G>C	uc001wkq.2	-	4	1954	c.1036C>G	c.(1036-1038)CTC>GTC	p.L346V	JPH4_uc010tnr.1_5'Flank|JPH4_uc001wkr.2_Missense_Mutation_p.L346V|JPH4_uc001wks.2_Missense_Mutation_p.L346V	NM_032452	NP_115828	Q96JJ6	JPH4_HUMAN	junctophilin 4	346	Cytoplasmic (Potential).|MORN 8.				calcium ion transport into cytosol|regulation of ryanodine-sensitive calcium-release channel activity	integral to membrane|junctional sarcoplasmic reticulum membrane				ovary(1)|pancreas(1)	2	all_cancers(95;0.000251)			GBM - Glioblastoma multiforme(265;0.00654)		AGAGGCAGGAGACTGCGGACG	0.731		NaN											0	0	0	0.001984	0	5	4									
PNN	5411	broad.mit.edu	37	14	39646875	39646875	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr14:39646875G>A	uc001wuw.3	+	5	503	c.406G>A	c.(406-408)GAA>AAA	p.E136K		NM_002687	NP_002678	Q9H307	PININ_HUMAN	pinin, desmosome associated protein	136	Necessary for interaction with RNPS1.|Necessary for mediating alternative 5' splicing.				cell adhesion|regulation of transcription, DNA-dependent|transcription, DNA-dependent	catalytic step 2 spliceosome|desmosome|intermediate filament|nuclear speck	DNA binding|protein binding|structural molecule activity			ovary(1)	1	Hepatocellular(127;0.213)		LUAD - Lung adenocarcinoma(48;0.000565)|Lung(238;0.000711)	GBM - Glioblastoma multiforme(112;0.0119)		AAATATGGATGAAAAGGGAAA	0.403		NaN											0	0	0	0.00361	0	57	134									
MDGA2	161357	broad.mit.edu	37	14	47504376	47504376	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr14:47504376C>G	uc001wwj.3	-	8	1646	c.1450G>C	c.(1450-1452)GTT>CTT	p.V484L	MDGA2_uc001wwi.3_Missense_Mutation_p.V255L|MDGA2_uc010ani.2_Missense_Mutation_p.V44L	NM_001113498	NP_001106970	Q7Z553	MDGA2_HUMAN	MAM domain containing 1 isoform 1	484	Ig-like 5.				spinal cord motor neuron differentiation	anchored to membrane|plasma membrane				ovary(4)|large_intestine(1)|pancreas(1)	6						GGCATTGCAACTTCTTTATCC	0.418		NaN											0	0	0	0.00361	0	57	108									
NIN	51199	broad.mit.edu	37	14	51288736	51288736	+	Silent	SNP	G	G	C			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr14:51288736G>C	uc001wym.2	-	3	230	c.39C>G	c.(37-39)CTC>CTG	p.L13L	NIN_uc001wyi.2_Silent_p.L13L|NIN_uc001wyj.2_RNA|NIN_uc001wyk.2_Silent_p.L13L|NIN_uc010tqp.1_Intron|NIN_uc001wyo.2_Silent_p.L13L|NIN_uc001wyp.1_Intron	NM_182946	NP_891991	Q8N4C6	NIN_HUMAN	ninein isoform 5	13	EF-hand 1.				centrosome localization	centrosome|microtubule	calcium ion binding|GTP binding|protein binding			skin(3)|ovary(1)|kidney(1)|central_nervous_system(1)	6	all_epithelial(31;0.00244)|Breast(41;0.127)					ACAGCTCCTTGAGTCGGGCCT	0.587		NaN	T	PDGFRB	MPD								0	0	0	0.00361	0	147	301									
DAAM1	23002	broad.mit.edu	37	14	59791171	59791171	+	Missense_Mutation	SNP	A	A	T			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr14:59791171A>T	uc001xdz.1	+	8	1113	c.988A>T	c.(988-990)AGG>TGG	p.R330W	DAAM1_uc001xea.1_Missense_Mutation_p.R330W|DAAM1_uc001xeb.1_Missense_Mutation_p.R330W	NM_014992	NP_055807	Q9Y4D1	DAAM1_HUMAN	dishevelled-associated activator of	330	GBD/FH3.				actin cytoskeleton organization	cytoplasm|plasma membrane	actin binding|Rho GTPase binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(108;0.165)		AACATTAGATAGGTAAGTCAG	0.289		NaN											0	0	0	0.001984	0	7	27									
C14orf115	55237	broad.mit.edu	37	14	74825233	74825233	+	Missense_Mutation	SNP	G	G	T			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr14:74825233G>T	uc001xpw.3	+	2	1938	c.1747G>T	c.(1747-1749)GAT>TAT	p.D583Y		NM_018228	NP_060698	Q9H8Y1	VRTN_HUMAN	hypothetical protein LOC55237	583					transposition, DNA-mediated		DNA binding|transposase activity				0				BRCA - Breast invasive adenocarcinoma(234;0.00147)		GGCTGGCAGGGATGTGACAGC	0.652		NaN											1	0	0.00829132	0.008291	0.0084463	11	108									
KIAA1409	57578	broad.mit.edu	37	14	94004479	94004479	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr14:94004479C>T	uc001ybv.1	+	9	819	c.736C>T	c.(736-738)CAC>TAC	p.H246Y	KIAA1409_uc001ybs.1_Missense_Mutation_p.H246Y|KIAA1409_uc001ybu.1_Missense_Mutation_p.H184Y	NM_020818	NP_065869	Q9P2D8	UNC79_HUMAN	hypothetical protein LOC57578	423						integral to membrane				ovary(10)|skin(4)|large_intestine(3)	17		all_cancers(154;0.0354)|all_epithelial(191;0.216)		Epithelial(152;0.188)		TGCGGAGACTCACCTCTATCA	0.592		NaN											0	0	0	0.006214	0	10	59									
RYR3	6263	broad.mit.edu	37	15	33962623	33962623	+	Missense_Mutation	SNP	T	T	G			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr15:33962623T>G	uc001zhi.2	+	38	5796	c.5726T>G	c.(5725-5727)GTT>GGT	p.V1909G	RYR3_uc010bar.2_Missense_Mutation_p.V1909G	NM_001036	NP_001027	Q15413	RYR3_HUMAN	ryanodine receptor 3	1909	4 X approximate repeats.|Cytoplasmic (By similarity).				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(5)|central_nervous_system(4)|lung(1)	10		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		TTGCTAGGGGTTCCTTTggaa	0.398		NaN											0	0	0	0.010818	0	16	24									
RYR3	6263	broad.mit.edu	37	15	34080596	34080596	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr15:34080596C>T	uc001zhi.2	+	67	9837	c.9767C>T	c.(9766-9768)GCG>GTG	p.A3256V	RYR3_uc010bar.2_Missense_Mutation_p.A3256V	NM_001036	NP_001027	Q15413	RYR3_HUMAN	ryanodine receptor 3	3256					cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(5)|central_nervous_system(4)|lung(1)	10		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		GACGAGTTCGCGGTCCTCTGC	0.567		NaN											0	0	0	0.00245	0	15	86									
RPUSD2	27079	broad.mit.edu	37	15	40861663	40861663	+	Missense_Mutation	SNP	G	G	T			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr15:40861663G>T	uc001zmd.1	+	1	127	c.127G>T	c.(127-129)GTT>TTT	p.V43F		NM_152260	NP_689473	Q8IZ73	RUSD2_HUMAN	RNA pseudouridylate synthase domain containing	43					pseudouridine synthesis		protein binding|pseudouridine synthase activity|RNA binding			skin(1)	1		all_cancers(109;2.74e-14)|all_epithelial(112;1.64e-11)|Lung NSC(122;6.69e-09)|all_lung(180;1.22e-07)|Melanoma(134;0.091)|Colorectal(260;0.175)|Ovarian(310;0.243)		GBM - Glioblastoma multiforme(113;3.1e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0786)		GTCTACCCAGGTTGGGACAGA	0.627		NaN											1	0	1.10923e-09	0.00278	1.20906e-09	25	40									
CASC5	57082	broad.mit.edu	37	15	40913273	40913273	+	Missense_Mutation	SNP	A	A	T			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr15:40913273A>T	uc010bbs.1	+	11	1050	c.889A>T	c.(889-891)ACT>TCT	p.T297S	CASC5_uc010ucq.1_Missense_Mutation_p.T121S|CASC5_uc001zme.2_Missense_Mutation_p.T271S|CASC5_uc010bbt.1_Missense_Mutation_p.T271S	NM_170589	NP_733468	Q8NG31	CASC5_HUMAN	cancer susceptibility candidate 5 isoform 1	297	Interaction with BUB1 and BUB1B.				acrosome assembly|attachment of spindle microtubules to kinetochore|cell division|CenH3-containing nucleosome assembly at centromere|mitotic prometaphase|spindle assembly checkpoint	acrosomal vesicle|condensed chromosome kinetochore|cytosol|nucleoplasm	protein binding			breast(3)|central_nervous_system(1)|skin(1)	5		all_cancers(109;2.03e-18)|all_epithelial(112;4.26e-15)|Lung NSC(122;1.12e-10)|all_lung(180;2.59e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.0946)		GBM - Glioblastoma multiforme(113;4.99e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0861)|COAD - Colon adenocarcinoma(120;0.211)		CAGTAATATTACTAGGCTCTT	0.373		NaN											0	0	0	0.009096	0	4	26									
MGA	23269	broad.mit.edu	37	15	42003201	42003201	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr15:42003201C>T	uc001zog.1	+	8	2829	c.2738C>T	c.(2737-2739)TCA>TTA	p.S913L	MGA_uc010ucy.1_Missense_Mutation_p.S913L|MGA_uc010ucz.1_Missense_Mutation_p.S913L	NM_001080541	NP_001074010	Q8IWI9	MGAP_HUMAN	MAX-interacting protein isoform 2	913						MLL1 complex	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(6)|kidney(3)|upper_aerodigestive_tract(1)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	12		all_cancers(109;0.00356)|all_epithelial(112;0.0413)|all_lung(180;0.18)|Ovarian(310;0.238)		OV - Ovarian serous cystadenocarcinoma(18;1.41e-18)|GBM - Glioblastoma multiforme(113;2.15e-06)|COAD - Colon adenocarcinoma(120;0.031)|Lung(196;0.0721)|BRCA - Breast invasive adenocarcinoma(123;0.0964)|Colorectal(105;0.0998)|LUSC - Lung squamous cell carcinoma(244;0.235)		CGAACTAAATCATCTTATAAA	0.403		NaN											0	0	0	0.004878	0	38	101									
SPG11	80208	broad.mit.edu	37	15	44951440	44951440	+	Silent	SNP	G	G	A			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr15:44951440G>A	uc001ztx.2	-	3	535	c.504C>T	c.(502-504)ATC>ATT	p.I168I	SPG11_uc010ueh.1_Silent_p.I168I|SPG11_uc010uei.1_Silent_p.I168I|SPG11_uc001zua.1_Silent_p.I168I	NM_025137	NP_079413	Q96JI7	SPTCS_HUMAN	spatacsin isoform 1	168	Extracellular (Potential).				cell death	cytosol|integral to membrane|nucleus	protein binding			ovary(4)|skin(1)	5		all_cancers(109;1.29e-14)|all_epithelial(112;1.26e-12)|Lung NSC(122;1.34e-07)|all_lung(180;1.21e-06)|Melanoma(134;0.0122)		all cancers(107;2.93e-22)|GBM - Glioblastoma multiforme(94;1.55e-06)|COAD - Colon adenocarcinoma(120;0.0432)|Colorectal(105;0.0484)|Lung(196;0.104)|LUSC - Lung squamous cell carcinoma(244;0.214)		CACATTTGTTGATGAACAGTA	0.358		NaN											0	0	0	0.00499	0	16	53									
SLC27A2	11001	broad.mit.edu	37	15	50526106	50526106	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr15:50526106G>C	uc001zxw.2	+	9	1829	c.1597G>C	c.(1597-1599)GAA>CAA	p.E533Q	SLC27A2_uc010bes.2_Missense_Mutation_p.E480Q|SLC27A2_uc001zxx.2_Missense_Mutation_p.E298Q	NM_003645	NP_003636	O14975	S27A2_HUMAN	solute carrier family 27 (fatty acid	533	Cytoplasmic (Potential).				bile acid biosynthetic process|fatty acid alpha-oxidation	endoplasmic reticulum membrane|integral to membrane|peroxisomal matrix|peroxisomal membrane	ATP binding|long-chain fatty acid-CoA ligase activity|phytanate-CoA ligase activity|pristanate-CoA ligase activity			ovary(1)|skin(1)	2		all_lung(180;0.00177)		all cancers(107;1.16e-06)|GBM - Glioblastoma multiforme(94;0.000113)		CAAAATGAAAGAAAACCATGA	0.373		NaN											0	0	0	0.001984	0	7	40									
HERC1	8925	broad.mit.edu	37	15	64017588	64017588	+	Silent	SNP	A	A	C			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr15:64017588A>C	uc002amp.2	-	18	3619	c.3471T>G	c.(3469-3471)CTT>CTG	p.L1157L	HERC1_uc010uil.1_Intron	NM_003922	NP_003913	Q15751	HERC1_HUMAN	hect domain and RCC1-like domain 1	1157					protein modification process|transport	cytosol|Golgi apparatus|membrane	acid-amino acid ligase activity|ARF guanyl-nucleotide exchange factor activity			ovary(6)|breast(6)|lung(5)|central_nervous_system(2)	19						GGGAGCCCTGAAGCATGCCAC	0.512		NaN											0	0	0	0.006122	0	19	110									
EDC3	80153	broad.mit.edu	37	15	74963915	74963915	+	Missense_Mutation	SNP	T	T	G			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr15:74963915T>G	uc002ayn.2	-	6	853	c.365A>C	c.(364-366)GAT>GCT	p.D122A	EDC3_uc002ayo.2_Missense_Mutation_p.D122A|EDC3_uc002aym.2_Missense_Mutation_p.D122A	NM_001142443	NP_001135915	Q96F86	EDC3_HUMAN	enhancer of mRNA decapping 3	122					exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	cytoplasmic mRNA processing body|cytosol	protein binding|RNA binding			ovary(1)	1						GCTCTTCACATCTGTCCTCTT	0.522		NaN											0	0	0	0.004482	0	9	146									
EFTUD1	79631	broad.mit.edu	37	15	82443993	82443993	+	Silent	SNP	G	G	A			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr15:82443993G>A	uc002bgt.1	-	18	2971	c.2802C>T	c.(2800-2802)TGC>TGT	p.C934C	EFTUD1_uc002bgs.1_Silent_p.C305C|EFTUD1_uc002bgu.1_Silent_p.C883C	NM_024580	NP_078856	Q7Z2Z2	ETUD1_HUMAN	elongation factor Tu GTP binding domain	934					mature ribosome assembly		GTP binding|GTPase activity|ribosome binding|translation elongation factor activity			ovary(1)	1						AGGCCTCAGAGCAGCCATCTT	0.458		NaN											0	0	0	0.001855	0	14	145									
ADAMTSL3	57188	broad.mit.edu	37	15	84581959	84581959	+	Nonsense_Mutation	SNP	G	G	T			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr15:84581959G>T	uc002bjz.3	+	16	2040	c.1816G>T	c.(1816-1818)GAG>TAG	p.E606*	ADAMTSL3_uc010bmt.1_Nonsense_Mutation_p.E606*|ADAMTSL3_uc010bmu.1_Nonsense_Mutation_p.E606*	NM_207517	NP_997400	P82987	ATL3_HUMAN	ADAMTS-like 3 precursor	606	TSP type-1 4.					proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			ovary(6)|central_nervous_system(5)|lung(5)|large_intestine(4)|breast(3)|skin(2)|kidney(1)|pancreas(1)	27			BRCA - Breast invasive adenocarcinoma(143;0.211)			TGAGCTGCCCGAGGAAGAGTG	0.637		NaN											1	0	9.16793e-09	0.00499	9.83567e-09	18	66									
NPRL3	8131	broad.mit.edu	37	16	162645	162645	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr16:162645C>T	uc002cfr.2	-	6	622	c.523G>A	c.(523-525)GAT>AAT	p.D175N	NPRL3_uc010uua.1_RNA|NPRL3_uc002cfp.1_RNA|NPRL3_uc002cfq.2_5'UTR|NPRL3_uc010uub.1_Missense_Mutation_p.D150N|NPRL3_uc010uuc.1_Missense_Mutation_p.D97N|NPRL3_uc002cfs.1_Missense_Mutation_p.D150N	NM_001077350	NP_001070818	Q12980	NPRL3_HUMAN	conserved gene telomeric to alpha globin cluster	175							protein binding			ovary(1)	1						GACACCTCATCCTGGAGCGCC	0.657		NaN											0	0	0	0.001984	0	7	19									
ATF7IP2	80063	broad.mit.edu	37	16	10566012	10566012	+	Silent	SNP	G	G	A			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr16:10566012G>A	uc002czu.2	+	8	1625	c.1398G>A	c.(1396-1398)TTG>TTA	p.L466L	ATF7IP2_uc002czv.2_Silent_p.L466L|ATF7IP2_uc010uyo.1_Intron|ATF7IP2_uc010uyp.1_Silent_p.L10L|ATF7IP2_uc002czw.2_Silent_p.L466L|ATF7IP2_uc010uyq.1_RNA	NM_024997	NP_079273	Q5U623	MCAF2_HUMAN	activating transcription factor 7 interacting	466					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus					0						GTCCTAATTTGACAACTCCAA	0.284		NaN											0	0	0	0.001368	0	11	15									
XYLT1	64131	broad.mit.edu	37	16	17232337	17232337	+	Missense_Mutation	SNP	C	C	A			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr16:17232337C>A	uc002dfa.2	-	8	1724	c.1639G>T	c.(1639-1641)GAC>TAC	p.D547Y		NM_022166	NP_071449	Q86Y38	XYLT1_HUMAN	xylosyltransferase I	547	Lumenal (Potential).				glycosaminoglycan biosynthetic process	endoplasmic reticulum membrane|extracellular region|Golgi membrane|integral to membrane	acetylglucosaminyltransferase activity|protein xylosyltransferase activity			ovary(4)	4						AGGTTGTTGTCCACCATGGTG	0.597		NaN											1	0	7.93312e-07	0.00245	8.33054e-07	11	102									
DNAH3	55567	broad.mit.edu	37	16	21133386	21133386	+	Silent	SNP	G	G	A			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr16:21133386G>A	uc010vbe.1	-	10	1464	c.1464C>T	c.(1462-1464)ATC>ATT	p.I488I	DNAH3_uc002die.2_Silent_p.I459I	NM_017539	NP_060009	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	488	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(10)|skin(3)|large_intestine(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	18				GBM - Glioblastoma multiforme(48;0.207)		GTTTGATCATGATTAGCTGAG	0.393		NaN											0	0	0	0.008361	0	31	70									
EEF2K	29904	broad.mit.edu	37	16	22237249	22237249	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr16:22237249G>A	uc002dki.2	+	2	684	c.199G>A	c.(199-201)GAG>AAG	p.E67K	EEF2K_uc002dkh.2_RNA	NM_013302	NP_037434	O00418	EF2K_HUMAN	elongation factor-2 kinase	67					insulin receptor signaling pathway|translational elongation	cytosol	ATP binding|calcium ion binding|calmodulin binding|elongation factor-2 kinase activity|translation factor activity, nucleic acid binding			large_intestine(1)	1				GBM - Glioblastoma multiforme(48;0.0223)		AACAAAAAGTGAGCGGTATAG	0.507		NaN											0	0	0	0.007291	0	28	66									
ZNF629	23361	broad.mit.edu	37	16	30795792	30795792	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr16:30795792C>G	uc002dzs.1	-	2	220	c.12G>C	c.(10-12)GAG>GAC	p.E4D		NM_001080417	NP_001073886	Q9UEG4	ZN629_HUMAN	zinc finger protein 629	4					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0			Colorectal(24;0.198)			ACAGCGCAGTCTCGGGCTCCA	0.632		NaN											0	0	0	0.000602	0	5	6									
ZNF629	23361	broad.mit.edu	37	16	30795800	30795800	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr16:30795800C>T	uc002dzs.1	-	2	212	c.4G>A	c.(4-6)GAG>AAG	p.E2K		NM_001080417	NP_001073886	Q9UEG4	ZN629_HUMAN	zinc finger protein 629	2					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0			Colorectal(24;0.198)			GTCTCGGGCTCCATCCCAGAG	0.632		NaN											0	0	0	0.004672	0	3	6									
ORAI3	93129	broad.mit.edu	37	16	30964944	30964944	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr16:30964944G>C	uc002eac.2	+	2	873	c.667G>C	c.(667-669)GAG>CAG	p.E223Q		NM_152288	NP_689501	Q9BRQ5	ORAI3_HUMAN	ORAI calcium release-activated calcium modulator	223						integral to membrane	protein binding				0						GTCCCAAGCTGAGCCAGCCTG	0.672		NaN									OREG0023742	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.012213	0	34	373									
SETD1A	9739	broad.mit.edu	37	16	30990892	30990892	+	Missense_Mutation	SNP	C	C	A			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr16:30990892C>A	uc002ead.1	+	14	4471	c.3785C>A	c.(3784-3786)ACC>AAC	p.T1262N		NM_014712	NP_055527	O15047	SET1A_HUMAN	SET domain containing 1A	1262					regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nuclear speck|Set1C/COMPASS complex	histone-lysine N-methyltransferase activity|nucleotide binding|protein binding|RNA binding			ovary(2)|skin(1)	3						CTGGCCCTGACCCCTGCCCGG	0.726		NaN											1	0	0.00621372	0.006214	0.00635361	10	36									
FUS	2521	broad.mit.edu	37	16	31195261	31195261	+	Nonsense_Mutation	SNP	C	C	A	rs73530286	byFrequency	TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr16:31195261C>A	uc002ebf.2	+	4	356	c.273C>A	c.(271-273)TAC>TAA	p.Y91*	FUS_uc002ebe.1_Nonsense_Mutation_p.Y91*|FUS_uc002ebh.2_Nonsense_Mutation_p.Y90*|FUS_uc002ebg.2_5'UTR|FUS_uc002ebi.2_Nonsense_Mutation_p.Y91*|FUS_uc002ebj.2_5'UTR|FUS_uc002ebk.1_5'Flank	NM_004960	NP_004951	P35637	FUS_HUMAN	fusion (involved in t(12;16) in malignant	91	Gln/Gly/Ser/Tyr-rich.				cell death|nuclear mRNA splicing, via spliceosome	nucleoplasm	DNA binding|nucleotide binding|protein binding|RNA binding|zinc ion binding		FUS/DDIT3(623)|FUS/ERG(163)|FUS/CREB3L2(158)|FUS/CREB3L1(6)|FUS/ATF1(4)|FUS/FEV(2)	soft_tissue(791)|haematopoietic_and_lymphoid_tissue(153)|bone(12)|breast(2)	958		Renal(780;0.000219)|Breast(268;0.00957)|Hepatocellular(780;0.121)		GBM - Glioblastoma multiforme(240;2.31e-05)|Kidney(780;0.000209)		AATCGTCTTACGGGCAGCAGT	0.572		NaN	T	DDIT3|ERG|FEV|ATF1|CREB3L2|CREB3L1	liposarcoma|AML|Ewing sarcoma|angiomatoid fibrous histiocytoma|fibromyxoid sarcoma								1	0	4.09656e-53	0.00361	4.80135e-53	133	199									
RSPRY1	89970	broad.mit.edu	37	16	57241994	57241994	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr16:57241994G>A	uc002elb.2	+	3	653	c.375G>A	c.(373-375)ATG>ATA	p.M125I	RSPRY1_uc002elc.2_Missense_Mutation_p.M125I|RSPRY1_uc002eld.2_Missense_Mutation_p.M125I	NM_133368	NP_588609	Q96DX4	RSPRY_HUMAN	ring finger and SPRY domain containing 1	125						extracellular region	zinc ion binding			ovary(1)	1						CCTATTCAATGATAACATTAC	0.294		NaN											0	0	0	0.00361	0	52	110									
GPR56	9289	broad.mit.edu	37	16	57687989	57687989	+	Missense_Mutation	SNP	T	T	C			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr16:57687989T>C	uc002emb.2	+	6	1004	c.712T>C	c.(712-714)TGG>CGG	p.W238R	GPR56_uc002elz.1_Missense_Mutation_p.W68R|GPR56_uc002ema.1_Missense_Mutation_p.W63R|GPR56_uc002emc.2_Missense_Mutation_p.W238R|GPR56_uc002emf.2_Missense_Mutation_p.W238R|GPR56_uc010vhs.1_Missense_Mutation_p.W238R|GPR56_uc002emd.2_Missense_Mutation_p.W238R|GPR56_uc002eme.2_Missense_Mutation_p.W238R|GPR56_uc010vht.1_Missense_Mutation_p.W243R|GPR56_uc002emg.3_Missense_Mutation_p.W238R|GPR56_uc010vhu.1_Missense_Mutation_p.W63R	NM_005682	NP_005673	Q9Y653	GPR56_HUMAN	G protein-coupled receptor 56 isoform a	238	Extracellular (Potential).				brain development|cell adhesion|cell-cell signaling|neuropeptide signaling pathway	integral to plasma membrane	G-protein coupled receptor activity				0						CGCCACGGTGTGGAAGCTCCA	0.652		NaN											0	0	0	0.004007	0	14	114									
SMPD3	55512	broad.mit.edu	37	16	68405651	68405651	+	Missense_Mutation	SNP	A	A	T			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr16:68405651A>T	uc002ewa.2	-	3	856	c.434T>A	c.(433-435)TTT>TAT	p.F145Y	SMPD3_uc010cfe.2_Missense_Mutation_p.F145Y|SMPD3_uc010vlh.1_Missense_Mutation_p.F145Y	NM_018667	NP_061137	Q9NY59	NSMA2_HUMAN	neutral sphingomyelin phosphodiesterase 3	145	Lumenal (Potential).				cell cycle|multicellular organismal development|sphingomyelin catabolic process	Golgi membrane|integral to membrane|plasma membrane	metal ion binding|sphingomyelin phosphodiesterase activity			skin(1)	1		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0184)|Epithelial(162;0.0785)	Phosphatidylserine(DB00144)	TTGGGTGTTAAAAAGGTTGTT	0.592		NaN											0	0	0	0.006214	0	9	26									
LRRC50	123872	broad.mit.edu	37	16	84203923	84203923	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr16:84203923G>A	uc002fhl.3	+	8	1670	c.1489G>A	c.(1489-1491)GAG>AAG	p.E497K	LRRC50_uc010vnw.1_Missense_Mutation_p.E261K	NM_178452	NP_848547	Q8NEP3	DAAF1_HUMAN	leucine rich repeat containing 50	497	Pro-rich.				axonemal dynein complex assembly|cilium morphogenesis	cilium axoneme|cytoplasm|spindle pole	dynein binding				0						CCTCCCAGCTGAGGCCCCACC	0.627		NaN							Kartagener_syndrome				0	0	0	0.010818	0	32	70									
KIAA0513	9764	broad.mit.edu	37	16	85100858	85100858	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr16:85100858C>T	uc002fiu.2	+	2	401	c.181C>T	c.(181-183)CCC>TCC	p.P61S	KIAA0513_uc002fis.3_Missense_Mutation_p.P61S|KIAA0513_uc010voj.1_Missense_Mutation_p.P61S|KIAA0513_uc002fit.2_Missense_Mutation_p.P61S	NM_014732	NP_055547	O60268	K0513_HUMAN	hypothetical protein LOC9764	61						cytoplasm				breast(1)	1				BRCA - Breast invasive adenocarcinoma(80;0.234)		GGGCGAGTCGCCCTCGCACCC	0.632		NaN											0	0	0	0.001168	0	6	98									
KIAA0513	9764	broad.mit.edu	37	16	85114926	85114926	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr16:85114926C>G	uc002fiu.2	+	9	1128	c.908C>G	c.(907-909)ACT>AGT	p.T303S	KIAA0513_uc010voj.1_Missense_Mutation_p.T303S	NM_014732	NP_055547	O60268	K0513_HUMAN	hypothetical protein LOC9764	303						cytoplasm				breast(1)	1				BRCA - Breast invasive adenocarcinoma(80;0.234)		TGCAGGCACACTCTGAGGTTC	0.567		NaN											0	0	0	0.008871	0	19	22									
GAS8	2622	broad.mit.edu	37	16	90099213	90099213	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr16:90099213C>G	uc002fqi.1	+	4	498	c.376C>G	c.(376-378)CTG>GTG	p.L126V	GAS8_uc010vps.1_Missense_Mutation_p.L101V|GAS8_uc002fqh.2_Missense_Mutation_p.L43V|GAS8_uc010vpt.1_Missense_Mutation_p.L126V|GAS8_uc010vpu.1_Missense_Mutation_p.L43V|GAS8_uc010vpv.1_Missense_Mutation_p.L97V|GAS8_uc010cjc.1_Missense_Mutation_p.L43V|GAS8_uc010vpw.1_Missense_Mutation_p.L43V|GAS8_uc002fqj.1_5'UTR|C16orf3_uc002fqk.1_5'Flank	NM_001481	NP_001472	O95995	GAS8_HUMAN	growth arrest-specific 8	126	Microtubule-binding.				negative regulation of cell proliferation|sperm motility	cilium|Golgi apparatus|microtubule|microtubule basal body|microtubule-based flagellum	protein binding			ovary(1)	1		all_cancers(9;4.44e-13)|Lung NSC(15;1.56e-06)|all_lung(18;2.18e-06)|all_neural(9;0.00118)|all_hematologic(23;0.0194)		BRCA - Breast invasive adenocarcinoma(80;0.029)		AGTCATGAAGCTGGCACAGAA	0.552		NaN											0	0	0	0.006214	0	9	166									
SERPINF1	5176	broad.mit.edu	37	17	1680704	1680704	+	Silent	SNP	C	C	G			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr17:1680704C>G	uc002ftl.2	+	8	1378	c.1221C>G	c.(1219-1221)CTC>CTG	p.L407L	SERPINF1_uc010cjw.2_Silent_p.L220L	NM_002615	NP_002606	P36955	PEDF_HUMAN	serine (or cysteine) proteinase inhibitor, clade	407					cell proliferation|negative regulation of angiogenesis|positive regulation of neurogenesis|regulation of proteolysis	extracellular space|melanosome	serine-type endopeptidase inhibitor activity			ovary(1)	1						GGGCCCTTCTCTTCATTGGCA	0.542		NaN											0	0	0	0.009535	0	29	202									
NEURL4	84461	broad.mit.edu	37	17	7222372	7222372	+	Silent	SNP	G	G	C			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr17:7222372G>C	uc002gga.1	-	22	3688	c.3681C>G	c.(3679-3681)CTC>CTG	p.L1227L	NEURL4_uc002gfy.1_RNA|GPS2_uc002gfz.1_5'UTR|NEURL4_uc002ggb.1_Silent_p.L1225L	NM_032442	NP_115818	Q96JN8	NEUL4_HUMAN	neuralized homolog 4 isoform 1	1227	NHR 6.						protein binding			upper_aerodigestive_tract(1)|ovary(1)	2						TACTCACCTTGAGACCGTTGT	0.627		NaN											0	0	0	0.00308	0	7	64									
DNAH2	146754	broad.mit.edu	37	17	7637562	7637562	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr17:7637562G>A	uc002giu.1	+	5	704	c.690G>A	c.(688-690)ATG>ATA	p.M230I	DNAH2_uc002git.2_Missense_Mutation_p.M230I|DNAH2_uc010vuk.1_Missense_Mutation_p.M230I	NM_020877	NP_065928	Q9P225	DYH2_HUMAN	dynein heavy chain domain 3	230	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(6)|skin(6)|central_nervous_system(1)	13		all_cancers(10;4.66e-07)|Prostate(122;0.081)				CCATGAACATGAAGCCTGAGA	0.537		NaN											0	0	0	0.004482	0	7	16									
MYOCD	93649	broad.mit.edu	37	17	12656344	12656344	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr17:12656344C>T	uc002gnn.2	+	10	2038	c.1739C>T	c.(1738-1740)CCT>CTT	p.P580L	MYOCD_uc002gno.2_Missense_Mutation_p.P580L|MYOCD_uc002gnp.1_Missense_Mutation_p.P484L|MYOCD_uc002gnq.2_Missense_Mutation_p.P299L	NM_153604	NP_705832	Q8IZQ8	MYCD_HUMAN	myocardin isoform 2	580					cardiac muscle cell differentiation|negative regulation of cell proliferation|negative regulation of cyclin-dependent protein kinase activity|positive regulation of smooth muscle cell differentiation|positive regulation of smooth muscle contraction|positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation|regulation of histone acetylation|smooth muscle cell differentiation	nucleus	nucleic acid binding|RNA polymerase II transcription factor binding transcription factor activity|transcription factor binding			central_nervous_system(2)|skin(2)|ovary(1)	5				UCEC - Uterine corpus endometrioid carcinoma (92;0.0969)		TCCAGCTGTCCTTTTGCATCC	0.512		NaN											0	0	0	0.00308	0	8	122									
DRG2	1819	broad.mit.edu	37	17	17997132	17997132	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr17:17997132G>A	uc002gsh.1	+	2	125	c.70G>A	c.(70-72)GAG>AAG	p.E24K	DRG2_uc010vxg.1_Missense_Mutation_p.E24K|DRG2_uc002gsi.1_RNA|DRG2_uc002gsj.1_Missense_Mutation_p.E24K	NM_001388	NP_001379	P55039	DRG2_HUMAN	developmentally regulated GTP binding protein 2	24					signal transduction		GTP binding			ovary(1)	1	all_neural(463;0.228)					TTTAGCCACTGAGTATCATCT	0.577		NaN											0	0	0	0.002836	0	31	77									
NOS2	4843	broad.mit.edu	37	17	26087165	26087165	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr17:26087165C>T	uc002gzu.2	-	25	3314	c.3050G>A	c.(3049-3051)CGC>CAC	p.R1017H		NM_000625	NP_000616	P35228	NOS2_HUMAN	nitric oxide synthase 2A	1017					arginine catabolic process|defense response to Gram-negative bacterium|innate immune response in mucosa|nitric oxide biosynthetic process|peptidyl-cysteine S-nitrosylation|platelet activation|positive regulation of killing of cells of other organism|positive regulation of leukocyte mediated cytotoxicity|regulation of cellular respiration|regulation of insulin secretion|superoxide metabolic process	cytosol|nucleus	arginine binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|protein homodimerization activity|tetrahydrobiopterin binding			skin(2)|ovary(1)|breast(1)	4					Dexamethasone(DB01234)|Hydrocortisone(DB00741)|L-Arginine(DB00125)|L-Citrulline(DB00155)	ATCTGGGCGGCGGCACCCAAA	0.652		NaN									OREG0024268	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.007413	0	19	104									
NEK8	284086	broad.mit.edu	37	17	27064966	27064966	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr17:27064966G>C	uc002hcp.2	+	7	1019	c.1019G>C	c.(1018-1020)GGG>GCG	p.G340A		NM_178170	NP_835464	Q86SG6	NEK8_HUMAN	NIMA-related kinase 8	340	RCC1 1.					cytoplasm|primary cilium	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			stomach(2)|ovary(1)|pancreas(1)|liver(1)|skin(1)	6	Lung NSC(42;0.0158)					GTGGCAGCTGGGCGCACGCAG	0.672		NaN											0	0	0	0.010729	0	10	163									
EFCAB5	374786	broad.mit.edu	37	17	28417662	28417662	+	Missense_Mutation	SNP	T	T	G			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr17:28417662T>G	uc002het.2	+	20	4099	c.3907T>G	c.(3907-3909)TCT>GCT	p.S1303A	EFCAB5_uc010cse.2_Missense_Mutation_p.S1058A|EFCAB5_uc010csf.2_Intron	NM_198529	NP_940931	A4FU69	EFCB5_HUMAN	EF-hand calcium binding domain 5 isoform a	1303							calcium ion binding			ovary(1)|skin(1)	2						TGGCGAGTTCTCTGGAGAGAT	0.383		NaN											0	0	0	0.004656	0	25	94									
AP2B1	163	broad.mit.edu	37	17	33977553	33977553	+	Missense_Mutation	SNP	C	C	A			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr17:33977553C>A	uc002hjr.2	+	13	1730	c.1541C>A	c.(1540-1542)TCT>TAT	p.S514Y	AP2B1_uc002hjq.2_Missense_Mutation_p.S514Y|AP2B1_uc010wci.1_Missense_Mutation_p.S476Y|AP2B1_uc002hjs.2_Missense_Mutation_p.S457Y|AP2B1_uc002hjt.2_Missense_Mutation_p.S514Y|AP2B1_uc010ctv.2_Missense_Mutation_p.S514Y|AP2B1_uc010wcj.1_Missense_Mutation_p.S251Y	NM_001282	NP_001273	P63010	AP2B1_HUMAN	adaptor-related protein complex 2, beta 1	514					axon guidance|epidermal growth factor receptor signaling pathway|intracellular protein transport|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|regulation of defense response to virus by virus|synaptic transmission|vesicle-mediated transport|viral reproduction	clathrin adaptor complex|coated pit|cytosol|endocytic vesicle membrane|plasma membrane	clathrin binding|protein transporter activity			ovary(1)	1		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0227)		CTTTAGGATTCTGATAATCCT	0.438		NaN											1	0	2.14674e-31	0.00361	2.47876e-31	52	82									
PLXDC1	57125	broad.mit.edu	37	17	37265201	37265201	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr17:37265201G>C	uc002hrg.2	-	4	637	c.425C>G	c.(424-426)CCT>CGT	p.P142R	PLXDC1_uc002hrh.2_RNA|PLXDC1_uc002hri.2_RNA|PLXDC1_uc002hrj.1_RNA|PLXDC1_uc002hrk.1_RNA	NM_020405	NP_065138	Q8IUK5	PXDC1_HUMAN	plexin domain containing 1 precursor	142	Extracellular (Potential).				angiogenesis	cytoplasm|extracellular region|integral to membrane|tight junction				ovary(1)|kidney(1)|skin(1)	3						CCCGTAGAAAGGGAAATCAAA	0.617		NaN											0	0	0	0.004007	0	14	29									
FKBP10	60681	broad.mit.edu	37	17	39977232	39977232	+	Silent	SNP	C	C	T	rs143450797	byFrequency	TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr17:39977232C>T	uc002hxv.2	+	8	1615	c.1290C>T	c.(1288-1290)CTC>CTT	p.L430L	FKBP10_uc002hxw.1_Silent_p.L194L	NM_021939	NP_068758	Q96AY3	FKB10_HUMAN	FK506 binding protein 10 precursor	430	PPIase FKBP-type 4.				protein folding	endoplasmic reticulum lumen|membrane	calcium ion binding|FK506 binding|peptidyl-prolyl cis-trans isomerase activity			ovary(1)	1		Breast(137;0.00122)		BRCA - Breast invasive adenocarcinoma(366;0.148)		AGGCGACTCTCGGGGCCAACA	0.701		NaN											0	0	0	0.009096	0	4	30									
NT5C3L	115024	broad.mit.edu	37	17	39991455	39991455	+	Missense_Mutation	SNP	T	T	A			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr17:39991455T>A	uc002hyc.3	-	3	292	c.283A>T	c.(283-285)AAT>TAT	p.N95Y	NT5C3L_uc002hxx.3_5'Flank|NT5C3L_uc010wfu.1_5'Flank|NT5C3L_uc002hyb.3_Missense_Mutation_p.N18Y|NT5C3L_uc002hyd.3_Missense_Mutation_p.N18Y|NT5C3L_uc002hxy.3_Missense_Mutation_p.N53Y|NT5C3L_uc002hxz.3_Missense_Mutation_p.N18Y|NT5C3L_uc002hya.3_Missense_Mutation_p.N53Y|KLHL10_uc010cxr.2_5'Flank|KLHL10_uc010wfv.1_5'Flank|KLHL10_uc010wfw.1_5'Flank	NM_052935	NP_443167	C9JKC4	C9JKC4_HUMAN	5'-nucleotidase, cytosolic III-like	61						cytoplasm	5'-nucleotidase activity|magnesium ion binding				0		Breast(137;0.000162)		BRCA - Breast invasive adenocarcinoma(366;0.15)		TGTGACTTACTGTAAGAAGAA	0.388		NaN											0	0	0	0.00361	0	49	72									
MPP2	4355	broad.mit.edu	37	17	41960382	41960382	+	Silent	SNP	G	G	C			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr17:41960382G>C	uc010wip.1	-	5	534	c.477C>G	c.(475-477)ACC>ACG	p.T159T	MPP2_uc002ien.1_Silent_p.T131T|MPP2_uc010wim.1_Silent_p.T103T|MPP2_uc002ieo.1_Silent_p.T114T|MPP2_uc010win.1_5'UTR|MPP2_uc010wio.1_Silent_p.T103T|MPP2_uc010czm.1_Silent_p.T97T	NM_005374	NP_005365	Q14168	MPP2_HUMAN	palmitoylated membrane protein 2	138	L27 2.				signal transduction	cell surface|integral to plasma membrane|membrane fraction	guanylate kinase activity				0		Breast(137;0.00314)		BRCA - Breast invasive adenocarcinoma(366;0.12)		GTGTCTCATAGGTCTTTGAGG	0.632		NaN											0	0	0	0.00308	0	8	98									
NGFR	4804	broad.mit.edu	37	17	47590264	47590264	+	Missense_Mutation	SNP	C	C	A			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr17:47590264C>A	uc002ioz.3	+	6	1302	c.1177C>A	c.(1177-1179)CAG>AAG	p.Q393K		NM_002507	NP_002498	P08138	TNR16_HUMAN	nerve growth factor receptor precursor	393	Cytoplasmic (Potential).|Death.				anti-apoptosis|apoptosis|induction of apoptosis by extracellular signals|membrane protein intracellular domain proteolysis|negative regulation of axonogenesis|negative regulation of cell cycle|nerve growth factor receptor signaling pathway|positive regulation of axonogenesis	cell surface|cytosol|endosome|extracellular region|integral to plasma membrane|nucleoplasm				ovary(1)|lung(1)	2	all_cancers(4;1.45e-13)|Breast(4;6.34e-28)|all_epithelial(4;4.95e-17)					CTGGGCCACCCAGGACAGCGC	0.692		NaN											1	0	7.07758e-08	0.004656	7.47535e-08	28	34									
NGFR	4804	broad.mit.edu	37	17	47590332	47590332	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr17:47590332G>C	uc002ioz.3	+	6	1370	c.1245G>C	c.(1243-1245)GAG>GAC	p.E415D		NM_002507	NP_002498	P08138	TNR16_HUMAN	nerve growth factor receptor precursor	415	Cytoplasmic (Potential).|Death.				anti-apoptosis|apoptosis|induction of apoptosis by extracellular signals|membrane protein intracellular domain proteolysis|negative regulation of axonogenesis|negative regulation of cell cycle|nerve growth factor receptor signaling pathway|positive regulation of axonogenesis	cell surface|cytosol|endosome|extracellular region|integral to plasma membrane|nucleoplasm				ovary(1)|lung(1)	2	all_cancers(4;1.45e-13)|Breast(4;6.34e-28)|all_epithelial(4;4.95e-17)					ACCTCGTGGAGAGTCTGTGCA	0.706		NaN											0	0	0	0.010729	0	10	14									
ITGA3	3675	broad.mit.edu	37	17	48156573	48156573	+	Missense_Mutation	SNP	C	C	A			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr17:48156573C>A	uc010dbl.2	+	20	2998	c.2534C>A	c.(2533-2535)CCC>CAC	p.P845H	ITGA3_uc010dbm.2_Missense_Mutation_p.P845H	NM_002204	NP_002195	P26006	ITA3_HUMAN	integrin alpha 3 isoform a precursor	845	Extracellular (Potential).				blood coagulation|cell-matrix adhesion|integrin-mediated signaling pathway|leukocyte migration	cell surface|integrin complex	protein binding|receptor activity			ovary(2)|pancreas(1)	3						GGGTCCTGGCCCTGCCGACCA	0.552		NaN											1	0	6.38683e-12	0.008361	7.0462e-12	28	266									
KIF2B	84643	broad.mit.edu	37	17	51900906	51900906	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr17:51900906G>A	uc002iua.2	+	1	668	c.512G>A	c.(511-513)CGA>CAA	p.R171Q	uc010wna.1_RNA	NM_032559	NP_115948	Q8N4N8	KIF2B_HUMAN	kinesin family member 2B	171	Potential.				blood coagulation|cell division|microtubule depolymerization|microtubule-based movement|mitotic prometaphase|regulation of chromosome segregation	condensed chromosome kinetochore|cytosol|microtubule|microtubule organizing center|nucleolus|spindle	ATP binding|microtubule motor activity			ovary(5)|skin(3)	8						CAGGAGATCCGAGCTAGACGC	0.532		NaN											0	0	0	0.00361	0	87	209									
RNF43	54894	broad.mit.edu	37	17	56435956	56435956	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr17:56435956G>A	uc002iwf.2	-	8	3137	c.1181C>T	c.(1180-1182)GCA>GTA	p.A394V	RNF43_uc010wnv.1_Missense_Mutation_p.A353V|RNF43_uc002iwh.3_Missense_Mutation_p.A394V|RNF43_uc002iwg.3_Missense_Mutation_p.A394V|RNF43_uc010dcw.2_Missense_Mutation_p.A267V	NM_017763	NP_060233	Q68DV7	RNF43_HUMAN	ring finger protein 43 precursor	394	Cytoplasmic (Potential).					endoplasmic reticulum membrane|integral to membrane|nuclear envelope	ligase activity|protein binding|zinc ion binding			ovary(1)	1	Medulloblastoma(34;0.127)|all_neural(34;0.237)					CCGGGGATGTGCAGCTCTGGG	0.682		NaN											0	0	0	0.001168	0	6	26									
BRIP1	83990	broad.mit.edu	37	17	59857637	59857637	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr17:59857637G>C	uc002izk.1	-	13	2061	c.1920C>G	c.(1918-1920)ATC>ATG	p.I640M	BRIP1_uc002izl.1_Missense_Mutation_p.I21M	NM_032043	NP_114432	Q9BX63	FANCJ_HUMAN	BRCA1 interacting protein C-terminal helicase 1	640					DNA damage checkpoint|double-strand break repair|regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding|protein binding			ovary(1)	1						AATTTTTAATGATATGATTAG	0.333		NaN	F|N|Mis			AML|leukemia|breast		Direct_reversal_of_damage|Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				0	0	0	0.001368	0	12	84									
KCNH6	81033	broad.mit.edu	37	17	61607729	61607729	+	Silent	SNP	G	G	A			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr17:61607729G>A	uc002jay.2	+	4	581	c.501G>A	c.(499-501)GGG>GGA	p.G167G	KCNH6_uc002jax.1_Silent_p.G167G|KCNH6_uc010wpl.1_Silent_p.G44G|KCNH6_uc010wpm.1_Silent_p.G167G|KCNH6_uc002jaz.1_Silent_p.G167G	NM_030779	NP_110406	Q9H252	KCNH6_HUMAN	potassium voltage-gated channel, subfamily H,	167	Cytoplasmic (Potential).				regulation of transcription, DNA-dependent|signal transduction					skin(1)	1					Ibutilide(DB00308)	GCGGACCAGGGCCAGGCACAG	0.637		NaN											0	0	0	0.008361	0	26	163									
LRRC37A3	374819	broad.mit.edu	37	17	62891163	62891163	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr17:62891163G>C	uc002jey.2	-	3	2744	c.2213C>G	c.(2212-2214)TCT>TGT	p.S738C	LRRC37A3_uc010wqg.1_Intron|LRRC37A3_uc010wqf.1_Intron|LRRC37A3_uc010dek.1_5'Flank	NM_199340	NP_955372	O60309	L37A3_HUMAN	leucine rich repeat containing 37, member A3	738	Extracellular (Potential).					integral to membrane					0						CGTGGTTGGAGATGGTTTAAC	0.512		NaN											0	0	0	0.00361	0	55	324									
SLC25A19	60386	broad.mit.edu	37	17	73282503	73282503	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr17:73282503G>C	uc002jns.3	-	2	1080	c.170C>G	c.(169-171)GCA>GGA	p.A57G	SLC25A19_uc010dge.2_Missense_Mutation_p.A57G|SLC25A19_uc002jnv.3_Missense_Mutation_p.A57G|SLC25A19_uc002jnu.3_Missense_Mutation_p.A57G|SLC25A19_uc002jnw.3_Missense_Mutation_p.A57G|SLC25A19_uc002jnt.3_Missense_Mutation_p.A57G	NM_021734	NP_068380	Q9HC21	TPC_HUMAN	solute carrier family 25, member 19	57	Solcar 1.					integral to membrane|mitochondrial inner membrane	binding|deoxynucleotide transmembrane transporter activity			ovary(1)	1	all_cancers(13;5.98e-08)|all_epithelial(9;1.16e-08)|Breast(9;3.1e-08)		all cancers(21;6.82e-07)|Epithelial(20;6.86e-06)			ATGGTACTTTGCGCTGGGGTC	0.537		NaN											0	0	0	0.00245	0	15	199									
CASKIN2	57513	broad.mit.edu	37	17	73498040	73498040	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr17:73498040G>C	uc002joc.2	-	18	3665	c.3115C>G	c.(3115-3117)CCC>GCC	p.P1039A	CASKIN2_uc010wsc.1_Missense_Mutation_p.P957A	NM_020753	NP_065804	Q8WXE0	CSKI2_HUMAN	cask-interacting protein 2 isoform a	1039	Pro-rich.					cytoplasm				pancreas(1)	1	all_cancers(13;3.15e-09)|all_epithelial(9;5.78e-10)|Breast(9;5.8e-10)|all_lung(278;0.246)		all cancers(21;4.57e-07)|Epithelial(20;2.92e-06)|Lung(188;0.0809)|LUSC - Lung squamous cell carcinoma(166;0.154)			CTGGGCTCGGGCTGGGGAAGG	0.697		NaN											0	0	0	0.008291	0	11	148									
EXOC7	23265	broad.mit.edu	37	17	74097809	74097809	+	Missense_Mutation	SNP	T	T	C			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr17:74097809T>C	uc002jqs.2	-	3	357	c.262A>G	c.(262-264)ATC>GTC	p.I88V	EXOC7_uc010dgv.1_Missense_Mutation_p.I35V|EXOC7_uc002jqq.2_Missense_Mutation_p.I88V|EXOC7_uc010wsw.1_Missense_Mutation_p.I88V|EXOC7_uc010wsx.1_Missense_Mutation_p.I88V|EXOC7_uc002jqr.2_Missense_Mutation_p.I88V|EXOC7_uc010wsv.1_Missense_Mutation_p.I47V|EXOC7_uc002jqu.2_Missense_Mutation_p.I88V|EXOC7_uc002jqv.2_Missense_Mutation_p.I88V	NM_001145297	NP_001138769	Q9UPT5	EXOC7_HUMAN	exocyst complex component 7 isoform 4	88					exocytosis|protein transport	centriolar satellite|cytosol|exocyst|plasma membrane	protein binding				0			LUSC - Lung squamous cell carcinoma(166;0.187)			TAGTAGCTGATGACATGGTCC	0.547		NaN											0	0	0	0.002836	0	31	285									
MGAT5B	146664	broad.mit.edu	37	17	74936492	74936492	+	Silent	SNP	C	C	T			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr17:74936492C>T	uc002jti.2	+	12	1723	c.1620C>T	c.(1618-1620)ATC>ATT	p.I540I	MGAT5B_uc002jth.2_Silent_p.I529I	NM_198955	NP_945193	Q3V5L5	MGT5B_HUMAN	N-acetylglucosaminyltranferase VB isoform 2	531	Lumenal (Potential).					Golgi membrane|integral to membrane	alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase activity|metal ion binding			ovary(2)|skin(1)	3						AGCTCTTCATCGGGTTTGGCT	0.662		NaN											0	0	0	0.00361	0	85	180									
SEC14L1	6397	broad.mit.edu	37	17	75189528	75189528	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr17:75189528C>T	uc002jto.2	+	6	638	c.371C>T	c.(370-372)ACC>ATC	p.T124I	SEC14L1_uc010dhc.2_Missense_Mutation_p.T124I|SEC14L1_uc010wth.1_Missense_Mutation_p.T124I|SEC14L1_uc002jtm.2_Missense_Mutation_p.T124I|SEC14L1_uc010wti.1_Missense_Mutation_p.T90I	NM_003003	NP_002994	Q92503	S14L1_HUMAN	SEC14 (S. cerevisiae)-like 1 isoform a	124	PRELI/MSF1.				transport	Golgi apparatus|integral to membrane	binding			ovary(2)	2						GAAGATTGGACCTGTTTTGAA	0.358		NaN											0	0	0	0.001168	0	6	92									
CBX4	8535	broad.mit.edu	37	17	77808858	77808858	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr17:77808858G>C	uc002jxe.2	-	5	746	c.583C>G	c.(583-585)CCC>GCC	p.P195A		NM_003655	NP_003646	O00257	CBX4_HUMAN	chromobox homolog 4	195	Interaction with BMI1.				anti-apoptosis|chromatin modification|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|PcG protein complex	enzyme binding|transcription corepressor activity			skin(2)	2			OV - Ovarian serous cystadenocarcinoma(97;0.0102)|BRCA - Breast invasive adenocarcinoma(99;0.0224)			CACTTGTCGGGCGGGTGGCTC	0.711		NaN									OREG0024799	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.007413	0	19	111									
CARD14	79092	broad.mit.edu	37	17	78162187	78162187	+	Silent	SNP	G	G	C			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr17:78162187G>C	uc002jxw.1	+	5	882	c.687G>C	c.(685-687)CTG>CTC	p.L229L	CARD14_uc002jxt.1_RNA|CARD14_uc002jxv.2_Silent_p.L229L|CARD14_uc010wud.1_RNA|CARD14_uc002jxx.2_5'UTR|CARD14_uc010dhu.1_Silent_p.L27L	NM_024110	NP_077015	Q9BXL6	CAR14_HUMAN	caspase recruitment domain protein 14 isoform 1	229	Potential.				activation of NF-kappaB-inducing kinase activity|positive regulation of protein phosphorylation|regulation of apoptosis	aggresome|cytoplasm|plasma membrane	CARD domain binding			ovary(4)|skin(1)	5	all_neural(118;0.0952)		OV - Ovarian serous cystadenocarcinoma(97;0.017)|BRCA - Breast invasive adenocarcinoma(99;0.0908)			TGTATCTACTGAAGCAGGAGC	0.587		NaN											0	0	0	0.004289	0	36	43									
SLC26A11	284129	broad.mit.edu	37	17	78195377	78195377	+	Silent	SNP	G	G	C			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr17:78195377G>C	uc002jyb.1	+	3	287	c.18G>C	c.(16-18)ACG>ACC	p.T6T	SGSH_uc002jxz.3_5'Flank|SGSH_uc002jya.3_5'Flank|SGSH_uc002jxy.2_5'Flank|SGSH_uc010wue.1_5'Flank|SLC26A11_uc002jyc.1_Silent_p.T6T|SLC26A11_uc002jyd.1_Silent_p.T6T|SLC26A11_uc010dhv.1_Silent_p.T6T	NM_173626	NP_775897	Q86WA9	S2611_HUMAN	solute carrier family 26, member 11	6	Extracellular (Potential).					endoplasmic reticulum|Golgi apparatus|integral to membrane|lysosomal membrane|plasma membrane	anion:anion antiporter activity|secondary active sulfate transmembrane transporter activity				0	all_neural(118;0.0538)		OV - Ovarian serous cystadenocarcinoma(97;0.0344)|BRCA - Breast invasive adenocarcinoma(99;0.0908)			CTTCGGTGACGGCGCTGGGTC	0.687		NaN											0	0	0	0.012319	0	22	20									
CCDC57	284001	broad.mit.edu	37	17	80115782	80115782	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr17:80115782G>A	uc002kdz.1	-	15	2438	c.2083C>T	c.(2083-2085)CTT>TTT	p.L695F	CCDC57_uc002kdx.1_Missense_Mutation_p.L695F|CCDC57_uc010dik.1_Missense_Mutation_p.L203F	NM_198082	NP_932348	Q2TAC2	CCD57_HUMAN	coiled-coil domain containing 57	695										ovary(2)	2	Breast(20;0.00285)|all_neural(118;0.0878)|all_lung(278;0.0949)|Lung NSC(278;0.128)|Ovarian(332;0.227)		BRCA - Breast invasive adenocarcinoma(99;0.0232)|OV - Ovarian serous cystadenocarcinoma(97;0.0253)			TCACGGGGAAGCTCACGCTGG	0.642		NaN											0	0	0	0.004672	0	3	18									
EMILIN2	84034	broad.mit.edu	37	18	2891874	2891874	+	Silent	SNP	G	G	A			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr18:2891874G>A	uc002kln.2	+	4	1908	c.1749G>A	c.(1747-1749)TTG>TTA	p.L583L		NM_032048	NP_114437	Q9BXX0	EMIL2_HUMAN	elastin microfibril interfacer 2 precursor	583	Potential.				cell adhesion	collagen	extracellular matrix constituent conferring elasticity|protein binding			skin(2)|ovary(1)	3				READ - Rectum adenocarcinoma(2;0.1)		TGCACCTTTTGAAATCTCTCA	0.458		NaN											0	0	0	0.006122	0	16	174									
LAMA1	284217	broad.mit.edu	37	18	6986291	6986291	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr18:6986291C>T	uc002knm.2	-	37	5318	c.5224G>A	c.(5224-5226)GAA>AAA	p.E1742K	LAMA1_uc010wzj.1_Missense_Mutation_p.E1218K	NM_005559	NP_005550	P25391	LAMA1_HUMAN	laminin, alpha 1 precursor	1742	Domain II and I.|Potential.				axon guidance|cell adhesion|cell surface receptor linked signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	extracellular space|laminin-1 complex|laminin-3 complex	extracellular matrix structural constituent|receptor binding			ovary(8)|large_intestine(4)|upper_aerodigestive_tract(2)|breast(2)|skin(2)|pancreas(2)|central_nervous_system(1)	21		Colorectal(10;0.172)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	ACCTCCAATTCTTCCAGCGGC	0.423		NaN											0	0	0	0.009535	0	31	276									
ANKRD12	23253	broad.mit.edu	37	18	9255911	9255912	+	Missense_Mutation	DNP	TA	TA	AG			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr18:9255911_9255912TA>AG	uc002knv.2	+	9	2903_2904	c.2646_2647TA>AG	c.(2644-2649)CATAAA>CAAGAA	p.882_883HK>QE	ANKRD12_uc002knw.2_Missense_Mutation_p.859_860HK>QE|ANKRD12_uc002knx.2_Missense_Mutation_p.859_860HK>QE|ANKRD12_uc010dkx.1_Missense_Mutation_p.589_590HK>QE	NM_015208	NP_056023	Q6UB98	ANR12_HUMAN	ankyrin repeat domain 12 isoform 1	882_883						nucleus				ovary(2)|central_nervous_system(1)	3						AAAAATGCCATAAAGAAGGTGA	0.332		NaN											0	0	0	0.004672	0	5	51									
MUM1	84939	broad.mit.edu	37	19	1370839	1370839	+	Missense_Mutation	SNP	A	A	G			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr19:1370839A>G	uc010xgm.1	+	11	1817	c.1748A>G	c.(1747-1749)AAG>AGG	p.K583R	MUM1_uc010dsi.2_Missense_Mutation_p.K515R|MUM1_uc002lrz.2_Missense_Mutation_p.K584R|MUM1_uc002lsb.2_Missense_Mutation_p.K515R			Q2TAK8	MUM1_HUMAN	SubName: Full=MUM1 protein;	583					chromatin organization|DNA repair	nucleus	nucleosome binding|protein binding				0		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;3.55e-06)|all_lung(49;5.41e-06)|Breast(49;0.000172)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GTGAAGGCCAAGGGCGCGGAG	0.662		NaN											0	0	0	0.00308	0	7	7									
PCSK4	54760	broad.mit.edu	37	19	1482190	1482190	+	Silent	SNP	G	G	T			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr19:1482190G>T	uc002ltb.1	-	15	1898	c.1836C>A	c.(1834-1836)GCC>GCA	p.A612A	C19orf25_uc010xgn.1_5'Flank|C19orf25_uc010dsk.2_5'Flank|C19orf25_uc010xgo.1_5'Flank|PCSK4_uc002lsz.2_Silent_p.A99A|PCSK4_uc002lta.2_3'UTR	NM_017573	NP_060043	Q6UW60	PCSK4_HUMAN	proprotein convertase subtilisin/kexin type 4	612					proteolysis	integral to membrane	serine-type endopeptidase activity				0		Acute lymphoblastic leukemia(61;3.02e-13)|all_hematologic(61;4.32e-09)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CCAGGATGTAGGCGGGGCCGT	0.716		NaN											1	0	6.4e-05	0.004672	6.62005e-05	2	3									
PCSK4	54760	broad.mit.edu	37	19	1482922	1482922	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr19:1482922C>G	uc002ltb.1	-	13	1731	c.1669G>C	c.(1669-1671)GAG>CAG	p.E557Q	PCSK4_uc002lsz.2_Missense_Mutation_p.E44Q|PCSK4_uc002lta.2_Intron	NM_017573	NP_060043	Q6UW60	PCSK4_HUMAN	proprotein convertase subtilisin/kexin type 4	557					proteolysis	integral to membrane	serine-type endopeptidase activity				0		Acute lymphoblastic leukemia(61;3.02e-13)|all_hematologic(61;4.32e-09)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CCCTTGTTCTCTAGGCCCAGG	0.627		NaN											0	0	0	0.00499	0	16	34									
REXO1	57455	broad.mit.edu	37	19	1827792	1827792	+	Silent	SNP	G	G	A			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr19:1827792G>A	uc002lua.3	-	2	1091	c.996C>T	c.(994-996)GGC>GGT	p.G332G	REXO1_uc010dsr.1_Silent_p.G286G	NM_020695	NP_065746	Q8N1G1	REXO1_HUMAN	transcription elongation factor B polypeptide 3	332						nucleus	exonuclease activity|nucleic acid binding				0		Ovarian(11;1.78e-06)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CCCGCAGGCCGCCCCCCTCGG	0.731		NaN											0	0	0	0.006214	0	8	8									
AP3D1	8943	broad.mit.edu	37	19	2102196	2102196	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr19:2102196C>T	uc002luz.2	-	30	3661	c.3438G>A	c.(3436-3438)ATG>ATA	p.M1146I	AP3D1_uc010dsv.2_Missense_Mutation_p.M236I|AP3D1_uc002luy.2_Missense_Mutation_p.M1105I|AP3D1_uc002lva.2_Missense_Mutation_p.M1208I	NM_003938	NP_003929	O14617	AP3D1_HUMAN	adaptor-related protein complex 3, delta 1	1146					eye pigment biosynthetic process|intracellular protein transport|regulation of sequestering of zinc ion|vesicle-mediated transport	endosome membrane|Golgi membrane|membrane coat	binding|protein transporter activity				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GCGTCGCCTTCATCTCTTCTA	0.572		NaN											0	0	0	0.00361	0	146	158									
ZNF555	148254	broad.mit.edu	37	19	2852510	2852510	+	Silent	SNP	A	A	G			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr19:2852510A>G	uc002lwo.2	+	4	536	c.447A>G	c.(445-447)GGA>GGG	p.G149G	ZNF555_uc002lwn.3_Silent_p.G148G	NM_152791	NP_690004	Q8NEP9	ZN555_HUMAN	zinc finger protein 555	149					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		ACACGTACGGAAAAGTCTTCA	0.458		NaN											0	0	0	0.001368	0	11	120									
PIAS4	51588	broad.mit.edu	37	19	4037409	4037409	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr19:4037409G>A	uc002lzg.2	+	10	1190	c.1180G>A	c.(1180-1182)GAC>AAC	p.D394N		NM_015897	NP_056981	Q8N2W9	PIAS4_HUMAN	protein inhibitor of activated STAT, 4	394					positive regulation of protein sumoylation|transcription, DNA-dependent|Wnt receptor signaling pathway	cytoplasm|PML body	DNA binding|SUMO ligase activity|ubiquitin protein ligase binding|zinc ion binding			pancreas(1)	1				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00461)|STAD - Stomach adenocarcinoma(1328;0.18)		TGAGGACGCCGACGAGATCGA	0.701		NaN											0	0	0	0.003163	0	14	32									
MUC16	94025	broad.mit.edu	37	19	9021060	9021060	+	Missense_Mutation	SNP	C	C	A			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr19:9021060C>A	uc002mkp.2	-	19	37467	c.37263G>T	c.(37261-37263)CAG>CAT	p.Q12421H		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	12423	Extracellular (Potential).|SEA 3.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						TCACCAGACCCTGCAGGACCC	0.547		NaN											1	0	7.03913e-09	0.001368	7.59668e-09	13	183									
TNPO2	30000	broad.mit.edu	37	19	12817453	12817453	+	Missense_Mutation	SNP	T	T	C			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr19:12817453T>C	uc002muo.2	-	13	1612	c.1427A>G	c.(1426-1428)AAG>AGG	p.K476R	TNPO2_uc002mup.2_Missense_Mutation_p.K568R|TNPO2_uc002muq.2_Missense_Mutation_p.K476R|TNPO2_uc002mur.2_Missense_Mutation_p.K476R|SNORD41_uc002mut.1_5'Flank	NM_001136196	NP_001129668	O14787	TNPO2_HUMAN	transportin 2 (importin 3, karyopherin beta 2b)	476	HEAT 8.				intracellular protein transport	cytoplasm|nucleus	nuclear localization sequence binding|protein binding|protein transporter activity			ovary(1)	1						CATCAGGGGCTTGAGGTGCAT	0.637		NaN											0	0	0	0.00308	0	7	77									
AKAP8L	26993	broad.mit.edu	37	19	15512114	15512114	+	Silent	SNP	G	G	C			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr19:15512114G>C	uc002naw.1	-	5	762	c.663C>G	c.(661-663)CTC>CTG	p.L221L	AKAP8L_uc002nax.1_RNA|AKAP8L_uc010xoh.1_Silent_p.L160L|AKAP8L_uc002nay.1_Silent_p.L221L|AKAP8L_uc002naz.2_Silent_p.L69L	NM_014371	NP_055186	Q9ULX6	AKP8L_HUMAN	A kinase (PRKA) anchor protein 8-like	221						cytoplasm|nuclear matrix	DEAD/H-box RNA helicase binding|DNA binding|zinc ion binding			ovary(1)	1						TCTGGGAGAAGAGGGAGGGCA	0.672		NaN											0	0	0	0.00361	0	87	93									
IL12RB1	3594	broad.mit.edu	37	19	18174753	18174753	+	Silent	SNP	C	C	T			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr19:18174753C>T	uc002nhw.1	-	13	1615	c.1551G>A	c.(1549-1551)ACG>ACA	p.T517T	IL12RB1_uc010xqb.1_Silent_p.T517T|IL12RB1_uc002nhx.1_Silent_p.T557T	NM_005535	NP_005526	P42701	I12R1_HUMAN	interleukin 12 receptor, beta 1 isoform 1	517	Extracellular (Potential).|Fibronectin type-III 5.				cellular response to interferon-gamma|interleukin-12-mediated signaling pathway|positive regulation of activated T cell proliferation|positive regulation of defense response to virus by host|positive regulation of interferon-gamma production|positive regulation of memory T cell differentiation|positive regulation of T cell mediated cytotoxicity|positive regulation of T-helper 1 type immune response|positive regulation of T-helper 17 cell lineage commitment|positive regulation of T-helper 17 type immune response	interleukin-12 receptor complex|interleukin-23 receptor complex	cytokine receptor activity			pancreas(1)	1						GCACCTGCACCGTGTAGGCTA	0.632		NaN											0	0	0	0.001368	0	11	21									
KIAA1683	80726	broad.mit.edu	37	19	18375916	18375916	+	Missense_Mutation	SNP	C	C	T	rs140540623		TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr19:18375916C>T	uc002nin.2	-	3	2650	c.2434G>A	c.(2434-2436)GTG>ATG	p.V812M	KIAA1683_uc010ebn.2_Missense_Mutation_p.V812M|KIAA1683_uc010xqe.1_Missense_Mutation_p.V766M	NM_025249	NP_079525	Q9H0B3	K1683_HUMAN	KIAA1683 isoform b	812						mitochondrion				ovary(2)	2						TTCCCCGGCACGTGTCCGTGG	0.687		NaN											0	0	0	0.004007	0	15	100									
NCAN	1463	broad.mit.edu	37	19	19337300	19337300	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr19:19337300C>T	uc002nlz.2	+	7	1177	c.1078C>T	c.(1078-1080)CAC>TAC	p.H360Y	NCAN_uc010ecc.1_5'UTR	NM_004386	NP_004377	O14594	NCAN_HUMAN	chondroitin sulfate proteoglycan 3 precursor	360					axon guidance|cell adhesion	extracellular region	calcium ion binding|hyaluronic acid binding|sugar binding			ovary(4)	4			Epithelial(12;0.00544)			CACAGCTCATCACCCCACGTC	0.562		NaN											0	0	0	0.001368	0	13	110									
ZNF93	81931	broad.mit.edu	37	19	20045094	20045094	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr19:20045094G>A	uc002non.2	+	4	1441	c.1330G>A	c.(1330-1332)GAG>AAG	p.E444K		NM_031218	NP_112495	P35789	ZNF93_HUMAN	zinc finger protein 93	444	C2H2-type 11.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			pancreas(1)	1						TAGTAAACATGAGATCATTCA	0.388		NaN											0	0	0	0.00333	0	23	41									
ZNF682	91120	broad.mit.edu	37	19	20135146	20135146	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr19:20135146G>C	uc002noq.2	-	2	166	c.43C>G	c.(43-45)CTG>GTG	p.L15V	ZNF682_uc002noo.2_5'UTR|ZNF682_uc002nop.2_5'UTR|ZNF682_uc010eck.2_Intron	NM_033196	NP_149973	O95780	ZN682_HUMAN	zinc finger protein 682 isoform 1	15	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|pancreas(1)	2						CACTCCTCCAGAGAGAATTCT	0.433		NaN											0	0	0	0.003954	0	25	58									
ZNF257	113835	broad.mit.edu	37	19	22271880	22271880	+	Missense_Mutation	SNP	C	C	A			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr19:22271880C>A	uc010ecx.2	+	4	1497	c.1328C>A	c.(1327-1329)TCT>TAT	p.S443Y	ZNF257_uc010ecy.2_Missense_Mutation_p.S411Y	NM_033468	NP_258429	Q9Y2Q1	ZN257_HUMAN	zinc finger protein 257	443	C2H2-type 10.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_lung(12;0.0961)|Lung NSC(12;0.103)				TTTAACCGGTCTTCATACCTT	0.408		NaN											1	0	0.000219431	0.00245	0.000226068	15	22									
MAG	4099	broad.mit.edu	37	19	35793494	35793494	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr19:35793494G>A	uc002nyy.1	+	7	1263	c.1114G>A	c.(1114-1116)GAG>AAG	p.E372K	MAG_uc002nyx.1_Missense_Mutation_p.E372K|MAG_uc010eds.1_Missense_Mutation_p.E347K|MAG_uc002nyz.1_Missense_Mutation_p.E372K	NM_002361	NP_002352	P20916	MAG_HUMAN	myelin associated glycoprotein isoform a	372	Ig-like C2-type 3.|Extracellular (Potential).				blood coagulation|cell adhesion|leukocyte migration|negative regulation of axonogenesis|nerve growth factor receptor signaling pathway	integral to membrane|plasma membrane	sugar binding			breast(3)|lung(2)|central_nervous_system(1)|skin(1)	7	all_lung(56;2.37e-08)|Lung NSC(56;3.66e-08)|Esophageal squamous(110;0.162)	Renal(1328;0.242)	Epithelial(14;3.14e-19)|OV - Ovarian serous cystadenocarcinoma(14;1.5e-18)|all cancers(14;1.5e-16)|LUSC - Lung squamous cell carcinoma(66;0.0417)			GGTCATCTACGAGAGCGAGCT	0.587		NaN											0	0	0	0.007291	0	28	137									
DPF1	8193	broad.mit.edu	37	19	38709684	38709684	+	Silent	SNP	G	G	A			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr19:38709684G>A	uc002ohl.2	-	4	421	c.394C>T	c.(394-396)CTG>TTG	p.L132L	DPF1_uc002ohm.2_Silent_p.L132L|DPF1_uc002ohn.2_Silent_p.L50L|DPF1_uc010xtu.1_Silent_p.L106L|DPF1_uc010xtv.1_Silent_p.L106L|DPF1_uc010xtw.1_Silent_p.L106L	NM_004647	NP_004638	Q92782	DPF1_HUMAN	D4, zinc and double PHD fingers family 1 isoform	132					induction of apoptosis|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nBAF complex	zinc ion binding				0	all_cancers(60;1.24e-06)		Lung(45;0.000246)|LUSC - Lung squamous cell carcinoma(53;0.000292)			TCCTTCTTCAGGGGTGCTTCA	0.612		NaN											0	0	0	0.007835	0	38	270									
LGALS4	3960	broad.mit.edu	37	19	39292958	39292958	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr19:39292958C>G	uc002ojg.2	-	8	871	c.657G>C	c.(655-657)AAG>AAC	p.K219N		NM_006149	NP_006140	P56470	LEG4_HUMAN	galectin-4	219	Galectin 2.				cell adhesion	cytosol|plasma membrane	sugar binding			ovary(1)|skin(1)	2	all_cancers(60;1.02e-05)|Ovarian(47;0.0454)		Lung(45;0.00416)|LUSC - Lung squamous cell carcinoma(53;0.00741)			CGTTATACCTCTTGCCTGTGG	0.328		NaN											0	0	0	0.00361	0	171	121									
CCDC97	90324	broad.mit.edu	37	19	41822706	41822706	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr19:41822706G>A	uc002oqg.2	+	2	586	c.464G>A	c.(463-465)CGT>CAT	p.R155H	CYP2F1_uc010xvw.1_Intron	NM_052848	NP_443080	Q96F63	CCD97_HUMAN	coiled-coil domain containing 97	155											0						ACCCGCCTGCGTAACCGGCGC	0.677		NaN											0	0	0	0.00361	0	44	61									
BCKDHA	593	broad.mit.edu	37	19	41930481	41930481	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr19:41930481G>A	uc002oqq.2	+	9	1335	c.1306G>A	c.(1306-1308)GAG>AAG	p.E436K	CYP2F1_uc010xvw.1_Intron|BCKDHA_uc002oqm.3_Missense_Mutation_p.E470K|BCKDHA_uc002oqr.2_Missense_Mutation_p.E435K|BCKDHA_uc010xvz.1_Missense_Mutation_p.E439K	NM_000709	NP_000700	P12694	ODBA_HUMAN	branched chain keto acid dehydrogenase E1, alpha	436					branched chain family amino acid catabolic process	mitochondrial alpha-ketoglutarate dehydrogenase complex	3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity|alpha-ketoacid dehydrogenase activity|carboxy-lyase activity|metal ion binding|protein binding				0						GACCTACGGGGAGCACTACCC	0.617		NaN											0	0	0	0.00874	0	38	149									
POU2F2	5452	broad.mit.edu	37	19	42600386	42600386	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr19:42600386G>A	uc002osp.2	-	8	578	c.511C>T	c.(511-513)CGC>TGC	p.R171C	POU2F2_uc002osn.2_Intron|POU2F2_uc002oso.2_5'UTR|POU2F2_uc002osq.2_Intron|POU2F2_uc002osr.1_Missense_Mutation_p.R171C	NM_002698	NP_002689	P09086	PO2F2_HUMAN	POU domain, class 2, transcription factor 2	171					humoral immune response|transcription from RNA polymerase II promoter	cytoplasm|nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|skin(1)	2		Prostate(69;0.059)				AGCGTAGGGCGGGTCACGGCC	0.706		NaN											0	0	0	0.000602	0	5	23									
PSG7	5676	broad.mit.edu	37	19	43441225	43441225	+	Missense_Mutation	SNP	C	C	A			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr19:43441225C>A	uc002ovl.3	-	1	106	c.4G>T	c.(4-6)GGG>TGG	p.G2W	PSG3_uc002ouf.2_5'Flank|PSG11_uc002ouw.2_Intron|PSG10_uc002ouv.1_Intron|PSG6_uc002ovh.1_Intron|PSG6_uc002ovi.2_Intron|PSG6_uc010xwk.1_Intron|PSG11_uc002ovk.1_Intron|PSG7_uc010xwl.1_Missense_Mutation_p.G2W	NM_002783	NP_002774	Q13046	PSG7_HUMAN	pregnancy specific beta-1-glycoprotein 7	2					female pregnancy	extracellular region					0		Prostate(69;0.00682)				GAGAGGGGCCCCATGGTCTCT	0.572		NaN											1	0	2.38352e-08	0.004289	2.5322e-08	34	161									
FBXO46	23403	broad.mit.edu	37	19	46216533	46216533	+	Nonsense_Mutation	SNP	G	G	C			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr19:46216533G>C	uc002pcy.2	-	2	346	c.221C>G	c.(220-222)TCA>TGA	p.S74*	FBXO46_uc002pcz.2_Nonsense_Mutation_p.S74*	NM_001080469	NP_001073938	Q6PJ61	FBX46_HUMAN	F-box protein 46	74							protein binding			ovary(1)|lung(1)|breast(1)	3		Ovarian(192;0.179)|all_neural(266;0.224)		OV - Ovarian serous cystadenocarcinoma(262;0.00568)|GBM - Glioblastoma multiforme(486;0.0844)|Epithelial(262;0.201)		AGCTGCTGCTGAGAGGAGCGG	0.642		NaN											0	0	0	0.003163	0	13	114									
GRLF1	2909	broad.mit.edu	37	19	47440614	47440614	+	Nonsense_Mutation	SNP	A	A	T			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr19:47440614A>T	uc010ekv.2	+	2	3775	c.3775A>T	c.(3775-3777)AAG>TAG	p.K1259*		NM_004491	NP_004482	Q9NRY4	RHG35_HUMAN	glucocorticoid receptor DNA binding factor 1	1259	Rho-GAP.				axon guidance|negative regulation of transcription, DNA-dependent|small GTPase mediated signal transduction|transcription, DNA-dependent	cytosol	DNA binding|Rho GTPase activator activity|transcription corepressor activity			central_nervous_system(1)	1		all_cancers(25;1.51e-09)|all_epithelial(76;1.87e-07)|all_lung(116;7.86e-06)|Lung NSC(112;2.31e-05)|Ovarian(192;0.0129)|all_neural(266;0.026)|Breast(70;0.077)		all cancers(93;2.03e-05)|OV - Ovarian serous cystadenocarcinoma(262;2.57e-05)|Epithelial(262;0.00135)|GBM - Glioblastoma multiforme(486;0.0289)		GACTCCAGAGAAGCCGATCCC	0.443		NaN											0	0	0	0.006214	0	9	113									
GRLF1	2909	broad.mit.edu	37	19	47440617	47440617	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr19:47440617C>G	uc010ekv.2	+	2	3778	c.3778C>G	c.(3778-3780)CCG>GCG	p.P1260A		NM_004491	NP_004482	Q9NRY4	RHG35_HUMAN	glucocorticoid receptor DNA binding factor 1	1260	Rho-GAP.				axon guidance|negative regulation of transcription, DNA-dependent|small GTPase mediated signal transduction|transcription, DNA-dependent	cytosol	DNA binding|Rho GTPase activator activity|transcription corepressor activity			central_nervous_system(1)	1		all_cancers(25;1.51e-09)|all_epithelial(76;1.87e-07)|all_lung(116;7.86e-06)|Lung NSC(112;2.31e-05)|Ovarian(192;0.0129)|all_neural(266;0.026)|Breast(70;0.077)		all cancers(93;2.03e-05)|OV - Ovarian serous cystadenocarcinoma(262;2.57e-05)|Epithelial(262;0.00135)|GBM - Glioblastoma multiforme(486;0.0289)		TCCAGAGAAGCCGATCCCCAT	0.443		NaN											0	0	0	0.006214	0	9	114									
MAMSTR	284358	broad.mit.edu	37	19	49218558	49218558	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr19:49218558G>C	uc002pkg.2	-	5	448	c.386C>G	c.(385-387)TCT>TGT	p.S129C	MAMSTR_uc002pkf.2_Missense_Mutation_p.S26C	NM_001130915	NP_001124387	Q6ZN01	MASTR_HUMAN	MEF2 activating motif and SAP domain containing	129	Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding			ovary(1)	1						TTCCCACAGAGATGGCCCAGG	0.627		NaN											0	0	0	0.000602	0	3	9									
FUT1	2523	broad.mit.edu	37	19	49254435	49254435	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr19:49254435C>T	uc002pkk.2	-	4	1079	c.104G>A	c.(103-105)GGC>GAC	p.G35D		NM_000148	NP_000139	P19526	FUT1_HUMAN	fucosyltransferase 1	35	Lumenal (Potential).				L-fucose catabolic process|protein glycosylation	Golgi cisterna membrane|integral to plasma membrane|membrane fraction	galactoside 2-alpha-L-fucosyltransferase activity			ovary(1)	1		all_lung(116;1.7e-06)|all_epithelial(76;3.52e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.000135)|all cancers(93;0.000354)|Epithelial(262;0.0191)|GBM - Glioblastoma multiforme(486;0.0222)		CAGGCCTAGGCCATGTGGAAA	0.602		NaN											0	0	0	0.004656	0	23	93									
TSKS	60385	broad.mit.edu	37	19	50266516	50266516	+	Splice_Site	SNP	C	C	T			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr19:50266516C>T	uc002ppm.2	-	1	1	c.-10_splice	c.e1-1			NM_021733	NP_068379	Q9UJT2	TSKS_HUMAN	testis-specific kinase substrate								protein binding			large_intestine(1)|skin(1)	2		all_lung(116;3.24e-07)|Lung NSC(112;1.6e-06)|all_neural(266;0.0459)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.00153)|GBM - Glioblastoma multiforme(134;0.0145)		GTGTGGGGGTCTGGCTCCCAG	0.632		NaN											0	0	0	0.00632	0	27	115									
TMEM150B	284417	broad.mit.edu	37	19	55824329	55824329	+	Silent	SNP	G	G	A			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr19:55824329G>A	uc010esw.1	-	8	773	c.600C>T	c.(598-600)GCC>GCT	p.A200A	TMEM150B_uc010yfu.1_Silent_p.A200A|TMEM150B_uc010yfv.1_RNA|TMEM150B_uc010yfw.1_RNA	NM_001085488	NP_001078957	A6NC51	T150B_HUMAN	transmembrane protein 150B precursor	200	Helical; (Potential).					integral to membrane					0						AGAAGTCAACGGCTAAGAGAC	0.682		NaN											0	0	0	0.004672	0	3	34									
ZNF471	57573	broad.mit.edu	37	19	57037045	57037045	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr19:57037045C>G	uc002qnh.2	+	5	1742	c.1609C>G	c.(1609-1611)CAT>GAT	p.H537D		NM_020813	NP_065864	Q9BX82	ZN471_HUMAN	zinc finger protein 471	537	C2H2-type 12.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)|ovary(1)	2		Colorectal(82;5.46e-05)|Ovarian(87;0.0822)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0307)		TCAGAAAACTCATACAGGAGA	0.393		NaN											0	0	0	0.006214	0	9	93									
ZNF460	10794	broad.mit.edu	37	19	57803086	57803086	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr19:57803086G>C	uc002qog.2	+	3	1499	c.1177G>C	c.(1177-1179)GAG>CAG	p.E393Q	ZNF460_uc010ygv.1_Missense_Mutation_p.E352Q	NM_006635	NP_006626	Q14592	ZN460_HUMAN	zinc finger protein 460	393	C2H2-type 8.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0694)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		AAAGCCTTTTGAGTGCAAAGA	0.468		NaN											0	0	0	0.003271	0	35	133									
ZNF551	90233	broad.mit.edu	37	19	58198132	58198132	+	Silent	SNP	G	G	A			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr19:58198132G>A	uc002qpw.3	+	3	664	c.441G>A	c.(439-441)AAG>AAA	p.K147K	ZNF551_uc002qpv.3_Silent_p.K90K|ZNF776_uc002qpx.2_Intron	NM_138347	NP_612356	Q7Z340	ZN551_HUMAN	zinc finger protein 551	163					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Colorectal(82;0.000256)|all_neural(62;0.0577)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0257)		GGAAAAGGAAGGTGGATGAGG	0.507		NaN											0	0	0	0.00361	0	119	94									
ZNF274	10782	broad.mit.edu	37	19	58723904	58723904	+	Missense_Mutation	SNP	C	C	A			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr19:58723904C>A	uc002qrq.1	+	10	1816	c.1357C>A	c.(1357-1359)CGT>AGT	p.R453S	ZNF274_uc002qrr.1_Missense_Mutation_p.R421S|ZNF274_uc002qrs.1_Missense_Mutation_p.R348S|ZNF274_uc010eum.1_Missense_Mutation_p.R212S	NM_133502	NP_598009	Q96GC6	ZN274_HUMAN	zinc finger protein 274 isoform c	453					viral reproduction	centrosome|nucleolus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			ovary(1)	1		Colorectal(82;5.46e-05)|all_neural(62;0.0182)|Ovarian(87;0.0443)|Breast(46;0.0889)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0168)|Lung(386;0.215)		ATTGCGCAAACGTGACTCACA	0.423		NaN											1	0	4.68919e-08	0.008291	4.972e-08	11	163									
FAM110C	642273	broad.mit.edu	37	2	45650	45650	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr2:45650G>A	uc010yim.1	-	1	736	c.736C>T	c.(736-738)CTC>TTC	p.L246F		NM_001077710	NP_001071178	Q1W6H9	F110C_HUMAN	hypothetical protein LOC642273	246						microtubule|microtubule organizing center|spindle pole					0	all_hematologic(175;0.0429)|Acute lymphoblastic leukemia(172;0.0627)	all_cancers(51;0.00221)		all cancers(51;0.000815)|Epithelial(75;0.00379)|OV - Ovarian serous cystadenocarcinoma(76;0.0127)|GBM - Glioblastoma multiforme(21;0.232)		CGCACCTTGAGGGTCACACAG	0.687		NaN											0	0	0	0.004672	0	3	31									
NBAS	51594	broad.mit.edu	37	2	15448382	15448382	+	Silent	SNP	T	T	A			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr2:15448382T>A	uc002rcc.1	-	40	4781	c.4755A>T	c.(4753-4755)CGA>CGT	p.R1585R	NBAS_uc010exl.1_Silent_p.R657R|NBAS_uc002rcd.1_RNA	NM_015909	NP_056993	A2RRP1	NBAS_HUMAN	neuroblastoma-amplified protein	1585										ovary(2)|liver(1)|skin(1)	4						ATGGGGCCAATCGGGCATAGA	0.463		NaN											0	0	0	0.001984	0	7	89									
SPAST	6683	broad.mit.edu	37	2	32340842	32340842	+	Silent	SNP	G	G	A			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr2:32340842G>A	uc002roc.2	+	6	1163	c.942G>A	c.(940-942)TTG>TTA	p.L314L	SPAST_uc002rod.2_Silent_p.L282L	NM_014946	NP_055761	Q9UBP0	SPAST_HUMAN	spastin isoform 1	314	Required for interaction with microtubules and microtubule severing.|Sufficient for microtubule severing.|Sufficient for interaction with microtubules.				cell cycle|cell death|cell differentiation|cytokinesis, completion of separation|ER to Golgi vesicle-mediated transport|microtubule bundle formation|microtubule severing|nervous system development|protein hexamerization|protein homooligomerization	endoplasmic reticulum|endosome|integral to membrane|microtubule|microtubule organizing center|nucleus|perinuclear region of cytoplasm|spindle	alpha-tubulin binding|ATP binding|beta-tubulin binding|microtubule binding|microtubule-severing ATPase activity			breast(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.208)					AAAAAGACTTGAAGAATTTTA	0.303		NaN											0	0	0	0.002836	0	30	48									
THADA	63892	broad.mit.edu	37	2	43808919	43808919	+	Missense_Mutation	SNP	A	A	G			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr2:43808919A>G	uc002rsw.3	-	8	1034	c.682T>C	c.(682-684)TGT>CGT	p.C228R	THADA_uc002rsx.3_Missense_Mutation_p.C228R|THADA_uc002rsy.3_RNA|THADA_uc002rsz.2_5'UTR|THADA_uc002rta.2_5'UTR|THADA_uc002rtb.1_Missense_Mutation_p.C228R|THADA_uc002rtc.3_Missense_Mutation_p.C228R|THADA_uc002rtd.2_Missense_Mutation_p.C228R	NM_001083953	NP_001077422	Q6YHU6	THADA_HUMAN	thyroid adenoma associated	228							binding			ovary(2)|skin(1)	3		Acute lymphoblastic leukemia(82;0.00361)|all_hematologic(82;0.00837)				AGCAATCCACACATATTTTGC	0.333		NaN											0	0	0	0.004482	0	8	72									
MSH6	2956	broad.mit.edu	37	2	48027760	48027760	+	Missense_Mutation	SNP	G	G	T			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr2:48027760G>T	uc002rwd.3	+	4	2790	c.2638G>T	c.(2638-2640)GAT>TAT	p.D880Y	MSH6_uc002rwc.2_Missense_Mutation_p.D880Y|MSH6_uc010fbj.2_Missense_Mutation_p.D578Y|MSH6_uc010yoi.1_Missense_Mutation_p.D750Y|MSH6_uc010yoj.1_Missense_Mutation_p.D578Y	NM_000179	NP_000170	P52701	MSH6_HUMAN	mutS homolog 6	880					determination of adult lifespan|DNA damage response, signal transduction resulting in induction of apoptosis|isotype switching|meiotic mismatch repair|negative regulation of DNA recombination|positive regulation of helicase activity|reciprocal meiotic recombination|response to UV|somatic hypermutation of immunoglobulin genes	MutSalpha complex	ATP binding|DNA-dependent ATPase activity|protein binding			large_intestine(53)|central_nervous_system(28)|endometrium(28)|stomach(22)|haematopoietic_and_lymphoid_tissue(9)|lung(7)|skin(6)|urinary_tract(5)|breast(5)|ovary(3)|thyroid(1)|upper_aerodigestive_tract(1)	168		Acute lymphoblastic leukemia(82;0.0299)|all_hematologic(82;0.0358)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)			AGAAGTTGCTGATGGTTTTAA	0.363		NaN	Mis|N|F|S		colorectal	colorectal|endometrial|ovarian		MMR	Lynch_syndrome|Muir-Torre_syndrome|Turcot_syndrome|Constitutional_Mismatch_Repair_Deficiency_Syndrome				1	0	1.96895e-08	0.00278	2.09585e-08	23	120									
NRXN1	9378	broad.mit.edu	37	2	51254845	51254845	+	Silent	SNP	G	G	A			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr2:51254845G>A	uc010fbq.2	-	2	2044	c.567C>T	c.(565-567)GTC>GTT	p.V189V	NRXN1_uc002rxe.3_Silent_p.V189V|NRXN1_uc002rxd.1_Silent_p.V189V	NM_001135659	NP_001129131	P58400	NRX1B_HUMAN	neurexin 1 isoform alpha2 precursor	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					angiogenesis|neuron cell-cell adhesion|neuronal signal transduction	cell surface|endocytic vesicle|integral to membrane|presynaptic membrane	cell adhesion molecule binding|receptor binding			ovary(2)	2		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.192)	Lung(47;0.0813)|LUSC - Lung squamous cell carcinoma(58;0.116)			GCGAGGAGTTGACCCTCACGT	0.721		NaN											0	0	0	0.003163	0	13	11									
C2orf63	130162	broad.mit.edu	37	2	55407749	55407749	+	Nonsense_Mutation	SNP	G	G	T			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr2:55407749G>T	uc002ryi.2	-	11	1627	c.1281C>A	c.(1279-1281)TAC>TAA	p.Y427*	C2orf63_uc002ryh.2_5'UTR|C2orf63_uc002ryj.2_Nonsense_Mutation_p.Y305*	NM_152385	NP_689598	Q8NHS4	CB063_HUMAN	hypothetical protein LOC130162 isoform 1	427							binding			ovary(2)|central_nervous_system(1)	3			LUSC - Lung squamous cell carcinoma(58;0.179)|Lung(47;0.189)			CACATTCACTGTAGACAATCT	0.448		NaN											1	0	7.88023e-25	0.00361	8.94735e-25	49	76									
CCDC104	112942	broad.mit.edu	37	2	55764680	55764680	+	Missense_Mutation	SNP	A	A	G			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr2:55764680A>G	uc002ryy.2	+	7	797	c.599A>G	c.(598-600)AAT>AGT	p.N200S	CCDC104_uc002ryx.2_Missense_Mutation_p.N225S	NM_080667	NP_542398	Q96G28	CC104_HUMAN	coiled-coil domain containing 104	200										ovary(1)	1			LUSC - Lung squamous cell carcinoma(58;0.127)|Lung(47;0.132)			ATAATGAATAATTCCCAAGGG	0.373		NaN											0	0	0	0.001984	0	6	101									
USP34	9736	broad.mit.edu	37	2	61622358	61622358	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr2:61622358G>A	uc002sbe.2	-	4	585	c.563C>T	c.(562-564)ACT>ATT	p.T188I		NM_014709	NP_055524	Q70CQ2	UBP34_HUMAN	ubiquitin specific protease 34	188					positive regulation of canonical Wnt receptor signaling pathway|protein K48-linked deubiquitination|ubiquitin-dependent protein catabolic process|Wnt receptor signaling pathway		cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(8)|breast(5)|skin(3)|lung(2)|prostate(1)	19			Epithelial(17;0.229)			ACTTTCTTGAGTTGATATATC	0.229		NaN											0	0	0	0.006214	0	10	11									
ETAA1	54465	broad.mit.edu	37	2	67630594	67630594	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr2:67630594G>C	uc002sdz.1	+	5	919	c.780G>C	c.(778-780)AAG>AAC	p.K260N		NM_019002	NP_061875	Q9NY74	ETAA1_HUMAN	ETAA16 protein	260						cytoplasm|nucleus				ovary(3)|large_intestine(1)	4						GAAACACCAAGATATCTGTGG	0.313		NaN											0	0	0	0.00245	0	15	87									
ARHGAP25	9938	broad.mit.edu	37	2	69002357	69002357	+	Silent	SNP	G	G	T			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr2:69002357G>T	uc002seu.2	+	2	430	c.66G>T	c.(64-66)CGG>CGT	p.R22R	ARHGAP25_uc010yqk.1_5'UTR|ARHGAP25_uc010fdg.2_Silent_p.R22R|ARHGAP25_uc010yql.1_Silent_p.R22R|ARHGAP25_uc002sev.2_Silent_p.R15R|ARHGAP25_uc002sew.2_Silent_p.R15R|ARHGAP25_uc002sex.2_Silent_p.R15R|ARHGAP25_uc010fdh.1_RNA	NM_001007231	NP_001007232	P42331	RHG25_HUMAN	Rho GTPase activating protein 25 isoform a	22					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			ovary(2)|breast(2)	4						CTATAGCTCGGTCAAGGAGTG	0.612		NaN											1	0	6.27289e-28	0.00361	7.1822e-28	45	599									
LOXL3	84695	broad.mit.edu	37	2	74779494	74779494	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr2:74779494C>G	uc002smp.1	-	2	340	c.268G>C	c.(268-270)GAG>CAG	p.E90Q	LOXL3_uc002smo.1_5'Flank|LOXL3_uc010ffm.1_Missense_Mutation_p.E90Q|LOXL3_uc002smq.1_Missense_Mutation_p.E90Q|LOXL3_uc010ffn.1_Missense_Mutation_p.E90Q|DOK1_uc002smr.2_Intron|DOK1_uc002sms.2_5'Flank|DOK1_uc010ffo.2_5'Flank|DOK1_uc002smt.2_5'Flank|DOK1_uc002smu.2_5'Flank|DOK1_uc010yrz.1_5'Flank|DOK1_uc002smv.2_5'Flank|DOK1_uc002smw.1_5'Flank	NM_032603	NP_115992	P58215	LOXL3_HUMAN	lysyl oxidase-like 3 precursor	90	SRCR 1.					extracellular space|membrane	copper ion binding|protein-lysine 6-oxidase activity|scavenger receptor activity				0						CCTGTGGCCTCTGTGAAGCCC	0.572		NaN											0	0	0	0.006122	0	16	85									
GGCX	2677	broad.mit.edu	37	2	85778102	85778102	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr2:85778102C>G	uc002sps.2	-	13	1940	c.1834G>C	c.(1834-1836)GAG>CAG	p.E612Q	GGCX_uc010yss.1_Missense_Mutation_p.E428Q|GGCX_uc010yst.1_Missense_Mutation_p.E555Q	NM_000821	NP_000812	P38435	VKGC_HUMAN	gamma-glutamyl carboxylase isoform 1	612	Lumenal (Potential).				blood coagulation|peptidyl-glutamic acid carboxylation|post-translational protein modification	endoplasmic reticulum membrane|integral to membrane|membrane fraction	gamma-glutamyl carboxylase activity			ovary(1)	1					Anisindione(DB01125)|Coagulation Factor IX(DB00100)|Coagulation factor VIIa(DB00036)|Drotrecogin alfa(DB00055)|L-Glutamic Acid(DB00142)|Menadione(DB00170)|Phytonadione(DB01022)	AGGTCTTGCTCCAGTGCAAGC	0.453		NaN											0	0	0	0.00361	0	101	120									
ANKRD36	375248	broad.mit.edu	37	2	97866233	97866233	+	Missense_Mutation	SNP	A	A	G			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr2:97866233A>G	uc010yva.1	+	46	3072	c.2828A>G	c.(2827-2829)GAA>GGA	p.E943G	ANKRD36_uc002sxp.3_RNA	NM_001164315	NP_001157787	A6QL64	AN36A_HUMAN	ankyrin repeat domain 36	943											0						ATAACCAGAGAAAAAAAGGAT	0.323		NaN											0	0	0	0.004672	0	2	11									
C2orf55	343990	broad.mit.edu	37	2	99463218	99463218	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr2:99463218C>T	uc002szf.1	-	2	340	c.46G>A	c.(46-48)GAA>AAA	p.E16K		NM_207362	NP_997245	Q6NV74	CB055_HUMAN	hypothetical protein LOC343990	16											0						CCAAGGCCTTCTGCAGCCTCC	0.527		NaN											0	0	0	0.00361	0	43	76									
GPR45	11250	broad.mit.edu	37	2	105859329	105859329	+	Silent	SNP	G	G	A			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr2:105859329G>A	uc002tco.1	+	1	1130	c.1014G>A	c.(1012-1014)TTG>TTA	p.L338L		NM_007227	NP_009158	Q9Y5Y3	GPR45_HUMAN	G protein-coupled receptor 45	338	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity|protein binding			ovary(1)|breast(1)|central_nervous_system(1)	3						GCATAGAGTTGCTGCCCCAGA	0.547		NaN											0	0	0	0.008871	0	21	195									
BUB1	699	broad.mit.edu	37	2	111399043	111399043	+	Splice_Site	SNP	T	T	C			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr2:111399043T>C	uc002tgc.2	-	22	2738	c.2626_splice	c.e22-1	p.N876_splice	BUB1_uc010yxh.1_Splice_Site_p.N856_splice|BUB1_uc010fkb.2_Intron	NM_004336	NP_004327	O43683	BUB1_HUMAN	budding uninhibited by benzimidazoles 1						apoptosis|cell division|chromosome segregation|interspecies interaction between organisms|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|regulation of sister chromatid cohesion	condensed chromosome kinetochore|cytosol	ATP binding|protein binding|protein serine/threonine kinase activity			lung(2)|breast(2)|stomach(1)|ovary(1)|kidney(1)	7		Ovarian(717;0.0822)		BRCA - Breast invasive adenocarcinoma(221;0.0556)		AATGGCATTCTAGGAACAATG	0.403		NaN											0	0	0	0.006999	0	37	105									
ZC3H6	376940	broad.mit.edu	37	2	113089651	113089651	+	Silent	SNP	G	G	A			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr2:113089651G>A	uc002thq.1	+	12	3550	c.3156G>A	c.(3154-3156)AGG>AGA	p.R1052R		NM_198581	NP_940983	P61129	ZC3H6_HUMAN	zinc finger CCCH-type domain containing 6	1052							nucleic acid binding|zinc ion binding			ovary(3)|central_nervous_system(1)	4						ATGACCCTAGGGATCACGGTT	0.453		NaN											0	0	0	0.005443	0	25	40									
INSIG2	51141	broad.mit.edu	37	2	118854145	118854145	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr2:118854145G>C	uc002tlk.2	+	2	219	c.13G>C	c.(13-15)GAG>CAG	p.E5Q	INSIG2_uc010yye.1_Intron	NM_016133	NP_057217	Q9Y5U4	INSI2_HUMAN	insulin induced protein 2	5					ER-nuclear sterol response pathway	SREBP-SCAP-Insig complex		p.E5K(1)		ovary(1)|central_nervous_system(1)	2						GGCAGAAGGAGAGACAGAGTC	0.418		NaN											0	0	0	0.002299	0	24	54									
PCDP1	200373	broad.mit.edu	37	2	120385260	120385260	+	Silent	SNP	G	G	C			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr2:120385260G>C	uc002tmb.2	+	17	1782	c.690G>C	c.(688-690)CGG>CGC	p.R230R	PCDP1_uc010yyq.1_Silent_p.R360R	NM_001029996	NP_001025167	Q4G0U5	PCDP1_HUMAN	primary ciliary dyskinesia protein 1	516						cilium	calmodulin binding				0	Colorectal(110;0.196)					TCCTGAGGCGGATCAGTCAGG	0.483		NaN											0	0	0	0.009535	0	30	227									
PTPN4	5775	broad.mit.edu	37	2	120725515	120725515	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr2:120725515G>A	uc002tmf.1	+	26	3432	c.2661G>A	c.(2659-2661)ATG>ATA	p.M887I	PTPN4_uc010flj.1_Missense_Mutation_p.M600I|PTPN4_uc010yyr.1_Missense_Mutation_p.M520I	NM_002830	NP_002821	P29074	PTN4_HUMAN	protein tyrosine phosphatase, non-receptor type	887	Tyrosine-protein phosphatase.					cytoplasm|cytoskeleton|internal side of plasma membrane	cytoskeletal protein binding|non-membrane spanning protein tyrosine phosphatase activity			ovary(2)	2					Alendronate(DB00630)	TAAGAACAATGAGAGATCAGC	0.373		NaN											0	0	0	0.00361	0	52	85									
GLI2	2736	broad.mit.edu	37	2	121747003	121747003	+	Silent	SNP	G	G	C			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr2:121747003G>C	uc010flp.2	+	13	3543	c.3513G>C	c.(3511-3513)CTG>CTC	p.L1171L	GLI2_uc002tmq.1_Intron|GLI2_uc002tmr.1_Intron|GLI2_uc002tmt.3_Silent_p.L843L|GLI2_uc002tmu.3_Silent_p.L826L	NM_005270	NP_005261	P10070	GLI2_HUMAN	GLI-Kruppel family member GLI2	1171					axon guidance|branching morphogenesis of a tube|cell proliferation|cerebellar cortex morphogenesis|developmental growth|embryonic digestive tract development|epidermal cell differentiation|floor plate formation|heart development|hindgut morphogenesis|kidney development|lung development|negative regulation of transcription from RNA polymerase II promoter|odontogenesis of dentine-containing tooth|osteoblast development|osteoblast differentiation|pituitary gland development|positive regulation of DNA replication|positive regulation of T cell differentiation in thymus|positive regulation of transcription from RNA polymerase II promoter|proximal/distal pattern formation|skeletal system development|smoothened signaling pathway involved in ventral spinal cord interneuron specification|spinal cord ventral commissure morphogenesis	nucleus|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|lung(2)|breast(1)|central_nervous_system(1)|pancreas(1)	13	Renal(3;0.0496)	Prostate(154;0.0623)				AGGGCAACCTGGCGGTGGTGC	0.632		NaN											0	0	0	0.000602	0	5	67									
CCDC74A	90557	broad.mit.edu	37	2	132290451	132290451	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr2:132290451G>C	uc002tta.2	+	6	943	c.891G>C	c.(889-891)AAG>AAC	p.K297N	CCDC74A_uc002ttb.2_Missense_Mutation_p.K231N	NM_138770	NP_620125	Q96AQ1	CC74A_HUMAN	coiled-coil domain containing 74A	297										skin(1)	1						GGCACCTCAAGTCCCTCCTGG	0.697		NaN											0	0	0	0.00308	0	8	97									
LCT	3938	broad.mit.edu	37	2	136575162	136575163	+	Missense_Mutation	DNP	CC	CC	TG			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr2:136575162_136575163CC>TG	uc002tuu.1	-	6	1466_1467	c.1455_1456GG>CA	c.(1453-1458)CAGGAT>CACAAT	p.485_486QD>HN		NM_002299	NP_002290	P09848	LPH_HUMAN	lactase-phlorizin hydrolase preproprotein	485_486	Extracellular (Potential).|4 X approximate repeats.|2.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|integral to plasma membrane|membrane fraction	cation binding|glycosylceramidase activity|lactase activity			ovary(7)|central_nervous_system(2)|skin(2)|pancreas(1)|lung(1)	13				BRCA - Breast invasive adenocarcinoma(221;0.169)		ATGCCCGCATCCTGTAGCCTGT	0.614		NaN											0	0	0	0.004672	0	9	86									
LRP1B	53353	broad.mit.edu	37	2	141092027	141092027	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr2:141092027G>A	uc002tvj.1	-	79	13190	c.12218C>T	c.(12217-12219)CCC>CTC	p.P4073L		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	4073	Extracellular (Potential).|LDL-receptor class B 35.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		CATACCTGTGGGTCTCTGTAA	0.363		NaN								TSP Lung(27;0.18)			0	0	0	0.002836	0	35	67									
LRP1B	53353	broad.mit.edu	37	2	141130656	141130656	+	Silent	SNP	A	A	C			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr2:141130656A>C	uc002tvj.1	-	69	11661	c.10689T>G	c.(10687-10689)GGT>GGG	p.G3563G		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	3563	Extracellular (Potential).|LDL-receptor class A 27.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		GTATACACTGACCATTGGAAC	0.353		NaN								TSP Lung(27;0.18)			0	0	0	0.001984	0	7	98									
ERMN	57471	broad.mit.edu	37	2	158178129	158178129	+	Missense_Mutation	SNP	A	A	G			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr2:158178129A>G	uc002tzh.2	-	3	771	c.509T>C	c.(508-510)ATG>ACG	p.M170T	ERMN_uc010zcj.1_Missense_Mutation_p.M64T|ERMN_uc010zck.1_Missense_Mutation_p.M150T|ERMN_uc002tzi.2_Missense_Mutation_p.M183T	NM_020711	NP_065762	Q8TAM6	ERMIN_HUMAN	ermin, ERM-like protein isoform b	170						cytoplasm|cytoskeleton				ovary(1)|skin(1)	2						AGAATGTAACATGTCAGCTTG	0.353		NaN											0	0	0	0.006999	0	40	220									
CCDC148	130940	broad.mit.edu	37	2	159035486	159035486	+	Silent	SNP	A	A	G			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr2:159035486A>G	uc002tzq.2	-	12	1656	c.1393T>C	c.(1393-1395)TTG>CTG	p.L465L	CCDC148_uc002tzr.2_Silent_p.L313L|CCDC148_uc010foh.2_Silent_p.L178L	NM_138803	NP_620158	Q8NFR7	CC148_HUMAN	coiled-coil domain containing 148	465										ovary(2)	2						CGCCTTTCCAATAATTCTTGT	0.403		NaN											0	0	0	0.004656	0	25	39									
PKP4	8502	broad.mit.edu	37	2	159477589	159477589	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr2:159477589G>C	uc002tzv.2	+	5	628	c.368G>C	c.(367-369)GGA>GCA	p.G123A	PKP4_uc002tzt.1_5'UTR|PKP4_uc002tzu.2_Missense_Mutation_p.G123A|PKP4_uc002tzw.2_Missense_Mutation_p.G123A|PKP4_uc002tzx.2_5'UTR|PKP4_uc002tzy.1_5'UTR|PKP4_uc002tzz.1_Missense_Mutation_p.G123A|PKP4_uc002uaa.2_5'UTR	NM_003628	NP_003619	Q99569	PKP4_HUMAN	plakophilin 4 isoform a	123					cell adhesion	desmosome	protein binding			ovary(5)|skin(2)	7						CCAGAACAAGGAACCCTCTAT	0.408		NaN								HNSCC(62;0.18)			0	0	0	0.001168	0	6	102									
BAZ2B	29994	broad.mit.edu	37	2	160257136	160257136	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr2:160257136C>G	uc002uao.2	-	17	3224	c.2872G>C	c.(2872-2874)GAA>CAA	p.E958Q	BAZ2B_uc002uap.2_Missense_Mutation_p.E922Q|BAZ2B_uc002uaq.1_Missense_Mutation_p.E788Q	NM_013450	NP_038478	Q9UIF8	BAZ2B_HUMAN	bromodomain adjacent to zinc finger domain, 2B	958	Lys-rich.|Potential.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(3)|skin(1)	4						GCTCGAAGTTCTTTTTCCATT	0.244		NaN											0	0	0	0.001368	0	13	39									
SCN2A	6326	broad.mit.edu	37	2	166231228	166231228	+	Missense_Mutation	SNP	T	T	A			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr2:166231228T>A	uc002udc.2	+	22	4296	c.4006T>A	c.(4006-4008)TCT>ACT	p.S1336T	SCN2A_uc002udd.2_Missense_Mutation_p.S1336T|SCN2A_uc002ude.2_Missense_Mutation_p.S1336T	NM_001040142	NP_001035232	Q99250	SCN2A_HUMAN	sodium channel, voltage-gated, type II, alpha	1336	III.				myelination	node of Ranvier|voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|breast(1)|pancreas(1)	8					Lamotrigine(DB00555)	AGCCATTCCATCTATCATGAA	0.333		NaN											0	0	0	0.00308	0	7	111									
MAP1D	254042	broad.mit.edu	37	2	172945092	172945092	+	Silent	SNP	G	G	A			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr2:172945092G>A	uc002uhk.2	+	10	1039	c.966G>A	c.(964-966)TCG>TCA	p.S322S	MAP1D_uc010zdw.1_Silent_p.S204S	NM_199227	NP_954697	Q6UB28	AMP1D_HUMAN	methionine aminopeptidase 1D precursor	322					N-terminal protein amino acid modification|peptidyl-methionine modification|proteolysis	mitochondrion	aminopeptidase activity|metal ion binding|metalloexopeptidase activity				0			OV - Ovarian serous cystadenocarcinoma(117;0.216)			TGATCACGTCGAGGGGCGCGC	0.612		NaN											0	0	0	0.00361	0	255	167									
TTN	7273	broad.mit.edu	37	2	179417524	179417524	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr2:179417524G>A	uc010zfg.1	-	284	82623	c.82399C>T	c.(82399-82401)CGT>TGT	p.R27467C	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.R21162C|TTN_uc010zfi.1_Missense_Mutation_p.R21095C|TTN_uc010zfj.1_Missense_Mutation_p.R20970C	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	28394							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GAGAGATCACGTATAGGAGCT	0.438		NaN											0	0	0	0.008291	0	10	100									
PMS1	5378	broad.mit.edu	37	2	190718686	190718686	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr2:190718686C>G	uc002urh.3	+	8	1373	c.844C>G	c.(844-846)CTG>GTG	p.L282V	PMS1_uc010zga.1_Missense_Mutation_p.L243V|PMS1_uc010zgb.1_Missense_Mutation_p.L221V|PMS1_uc002urk.3_Missense_Mutation_p.L243V|PMS1_uc002uri.3_Missense_Mutation_p.L282V|PMS1_uc010zgc.1_Missense_Mutation_p.L106V|PMS1_uc010zgd.1_Missense_Mutation_p.L106V|PMS1_uc002urj.2_RNA|PMS1_uc010fry.1_Missense_Mutation_p.L243V|PMS1_uc010frz.2_Intron|PMS1_uc002url.2_Missense_Mutation_p.L67V|PMS1_uc002urm.2_RNA|PMS1_uc002urn.1_Translation_Start_Site	NM_000534	NP_000525	P54277	PMS1_HUMAN	postmeiotic segregation 1 isoform a	282					mismatch repair|reciprocal meiotic recombination	MutLalpha complex	ATP binding|ATPase activity|mismatched DNA binding			ovary(2)|kidney(1)|central_nervous_system(1)	4			OV - Ovarian serous cystadenocarcinoma(117;0.0013)|Epithelial(96;0.0263)|all cancers(119;0.0751)			TCATTACAATCTGAAATGCCT	0.279		NaN	Mis|N			colorectal|endometrial|ovarian		Direct_reversal_of_damage|MMR					0	0	0	0.00308	0	6	57									
PMS1	5378	broad.mit.edu	37	2	190718983	190718983	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr2:190718983C>T	uc002urh.3	+	9	1514	c.985C>T	c.(985-987)CTT>TTT	p.L329F	PMS1_uc010zga.1_Missense_Mutation_p.L290F|PMS1_uc010zgb.1_Missense_Mutation_p.L268F|PMS1_uc002urk.3_Missense_Mutation_p.L290F|PMS1_uc002uri.3_Missense_Mutation_p.L329F|PMS1_uc010zgc.1_Missense_Mutation_p.L153F|PMS1_uc010zgd.1_Missense_Mutation_p.L153F|PMS1_uc002urj.2_RNA|PMS1_uc010fry.1_Missense_Mutation_p.L290F|PMS1_uc010frz.2_Intron|PMS1_uc002url.2_Missense_Mutation_p.L114F|PMS1_uc002urm.2_RNA|PMS1_uc002urn.1_5'UTR	NM_000534	NP_000525	P54277	PMS1_HUMAN	postmeiotic segregation 1 isoform a	329					mismatch repair|reciprocal meiotic recombination	MutLalpha complex	ATP binding|ATPase activity|mismatched DNA binding			ovary(2)|kidney(1)|central_nervous_system(1)	4			OV - Ovarian serous cystadenocarcinoma(117;0.0013)|Epithelial(96;0.0263)|all cancers(119;0.0751)			TTTAATTGCTCTTGAAAATCT	0.254		NaN	Mis|N			colorectal|endometrial|ovarian		Direct_reversal_of_damage|MMR					0	0	0	0.004482	0	9	47									
MDH1B	130752	broad.mit.edu	37	2	207619970	207619970	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr2:207619970G>C	uc002vbs.2	-	5	728	c.673C>G	c.(673-675)CTG>GTG	p.L225V	MDH1B_uc010ziw.1_Intron|MDH1B_uc010fui.2_Missense_Mutation_p.L225V|MDH1B_uc010fuj.2_Missense_Mutation_p.L127V|MDH1B_uc002vbt.2_Intron	NM_001039845	NP_001034934	Q5I0G3	MDH1B_HUMAN	malate dehydrogenase 1B, NAD (soluble)	225					carbohydrate metabolic process|malate metabolic process|tricarboxylic acid cycle		binding|malate dehydrogenase activity			ovary(3)|kidney(1)	4				LUSC - Lung squamous cell carcinoma(261;0.0763)|Epithelial(149;0.131)|Lung(261;0.145)		CAGTCCTCCAGAGTGAACACC	0.577		NaN											0	0	0	0.00874	0	44	35									
KIAA1486	57624	broad.mit.edu	37	2	226447337	226447337	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr2:226447337G>C	uc002voe.2	+	4	1379	c.1204G>C	c.(1204-1206)GGA>CGA	p.G402R	KIAA1486_uc010fxa.1_Intron|KIAA1486_uc002vof.1_Missense_Mutation_p.G172R	NM_020864	NP_065915	Q9P242	K1486_HUMAN	hypothetical protein LOC57624	402	Pro-rich.									ovary(2)|central_nervous_system(1)	3		Renal(207;0.0112)|all_lung(227;0.0477)|Lung NSC(271;0.0644)|all_hematologic(139;0.101)|Esophageal squamous(248;0.129)		Epithelial(121;6.73e-10)|all cancers(144;4.32e-07)|Lung(261;0.0161)|LUSC - Lung squamous cell carcinoma(224;0.0223)		CGCGGCCCTGGGACCTGCCTC	0.667		NaN											0	0	0	0.000602	0	5	4									
CSNK2A1	1457	broad.mit.edu	37	20	469337	469337	+	Missense_Mutation	SNP	T	T	C			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr20:469337T>C	uc002wdw.1	-	11	1202	c.809A>G	c.(808-810)AAT>AGT	p.N270S	CSNK2A1_uc002wdx.1_Missense_Mutation_p.N270S|CSNK2A1_uc002wdy.1_Missense_Mutation_p.N134S	NM_177559	NP_808227	P68400	CSK21_HUMAN	casein kinase II alpha 1 subunit isoform a	270	Protein kinase.				axon guidance|Wnt receptor signaling pathway	cytosol|NuRD complex|plasma membrane|Sin3 complex	ATP binding|protein N-terminus binding|protein serine/threonine kinase activity			ovary(1)	1		Breast(17;0.231)	OV - Ovarian serous cystadenocarcinoma(29;0.0969)			CAAGATATCATTGAAACGTGG	0.358		NaN											0	0	0	0.00361	0	47	33									
C20orf194	25943	broad.mit.edu	37	20	3305600	3305600	+	Nonsense_Mutation	SNP	C	C	A			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr20:3305600C>A	uc002wii.2	-	14	1255	c.1204G>T	c.(1204-1206)GAG>TAG	p.E402*	C20orf194_uc002wij.3_Nonsense_Mutation_p.E141*|C20orf194_uc002wik.2_Nonsense_Mutation_p.E76*|C20orf194_uc010gay.1_RNA	NM_001009984	NP_001009984	Q5TEA3	CT194_HUMAN	hypothetical protein LOC25943	402											0						AGAGTTTGCTCTGCTACCTCC	0.413		NaN											1	0	3.03874e-20	0.003271	3.42881e-20	36	114									
PLCB4	5332	broad.mit.edu	37	20	9400495	9400495	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr20:9400495C>T	uc002wnf.2	+	24	2193	c.2057C>T	c.(2056-2058)ACA>ATA	p.T686I	PLCB4_uc010gbw.1_Missense_Mutation_p.T686I|PLCB4_uc010gbx.2_Missense_Mutation_p.T698I|PLCB4_uc002wne.2_Missense_Mutation_p.T686I|PLCB4_uc002wnh.2_Missense_Mutation_p.T533I	NM_182797	NP_877949	Q15147	PLCB4_HUMAN	phospholipase C beta 4 isoform b	686					intracellular signal transduction|lipid catabolic process	cytosol	calcium ion binding|phosphatidylinositol phospholipase C activity|protein binding|signal transducer activity			skin(11)|ovary(3)|pancreas(1)	15						CCTGATCGAACATTTGACCCC	0.433		NaN											0	0	0	0.00333	0	23	277									
ASXL1	171023	broad.mit.edu	37	20	31023699	31023699	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr20:31023699C>T	uc002wxs.2	+	12	3610	c.3184C>T	c.(3184-3186)CCT>TCT	p.P1062S	ASXL1_uc010geb.2_Missense_Mutation_p.P953S	NM_015338	NP_056153	Q8IXJ9	ASXL1_HUMAN	additional sex combs like 1 isoform 1	1062					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	PR-DUB complex	metal ion binding|protein binding			haematopoietic_and_lymphoid_tissue(239)|large_intestine(6)|central_nervous_system(2)|ovary(1)	248						GATGGTTGCTCCTCAGAGCTG	0.547		NaN	F|N|Mis		MDS|CMML								0	0	0	0.00361	0	93	156									
EDEM2	55741	broad.mit.edu	37	20	33719493	33719493	+	Nonsense_Mutation	SNP	T	T	A			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr20:33719493T>A	uc002xbo.2	-	7	896	c.796A>T	c.(796-798)AAA>TAA	p.K266*	EDEM2_uc010zuv.1_Nonsense_Mutation_p.K225*|EDEM2_uc010zus.1_Nonsense_Mutation_p.K45*|EDEM2_uc002xbq.2_Nonsense_Mutation_p.K229*|EDEM2_uc010zut.1_Nonsense_Mutation_p.K225*|EDEM2_uc002xbp.2_Nonsense_Mutation_p.K114*|EDEM2_uc002xbn.2_Nonsense_Mutation_p.K114*|EDEM2_uc002xbr.2_Intron|EDEM2_uc010zuu.1_5'UTR	NM_018217	NP_060687	Q9BV94	EDEM2_HUMAN	ER degradation enhancer, mannosidase alpha-like	266					post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine|response to unfolded protein	endoplasmic reticulum lumen|endoplasmic reticulum membrane|extracellular region	calcium ion binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity|misfolded protein binding				0			BRCA - Breast invasive adenocarcinoma(18;0.00936)			ATGGCTCCTTTCACCAAGTAC	0.527		NaN											0	0	0	0.005524	0	40	357									
L3MBTL	26013	broad.mit.edu	37	20	42159033	42159033	+	Missense_Mutation	SNP	C	C	A			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr20:42159033C>A	uc010zwh.1	+	10	1146	c.1100C>A	c.(1099-1101)ACG>AAG	p.T367K	L3MBTL_uc002xkl.2_Missense_Mutation_p.T299K|L3MBTL_uc002xkm.2_Missense_Mutation_p.T299K|L3MBTL_uc010ggl.2_Missense_Mutation_p.T299K|L3MBTL_uc002xkn.1_Missense_Mutation_p.T58K|L3MBTL_uc002xko.2_5'Flank	NM_015478	NP_056293	Q9Y468	LMBL1_HUMAN	l(3)mbt-like isoform I	299	MBT 1.				chromatin modification|hemopoiesis|negative regulation of transcription, DNA-dependent|regulation of megakaryocyte differentiation|regulation of mitosis	chromatin|condensed chromosome|nucleoplasm	identical protein binding|methylated histone residue binding|nucleosomal histone binding|SAM domain binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Myeloproliferative disorder(115;0.00452)	COAD - Colon adenocarcinoma(18;0.0031)			TTCGAGAAGACGGGCCACAAG	0.577		NaN											1	0	6.49762e-13	0.006122	7.19757e-13	16	220									
MATN4	8785	broad.mit.edu	37	20	43932954	43932954	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr20:43932954G>A	uc002xnn.2	-	3	744	c.557C>T	c.(556-558)TCG>TTG	p.S186L	MATN4_uc002xno.2_Missense_Mutation_p.S186L|MATN4_uc002xnp.2_Missense_Mutation_p.S186L|MATN4_uc010zwr.1_Missense_Mutation_p.S134L|MATN4_uc002xnr.1_Missense_Mutation_p.S186L|RBPJL_uc002xns.2_5'Flank|RBPJL_uc002xnt.2_5'Flank	NM_003833	NP_003824	O95460	MATN4_HUMAN	matrilin 4 isoform 1 precursor	186	VWFA 1.					extracellular region	protein binding				0		Myeloproliferative disorder(115;0.0122)				TAGCGGGGGCGATGCCATGGC	0.682		NaN											0	0	0	0.00361	0	49	76									
WFDC8	90199	broad.mit.edu	37	20	44181845	44181845	+	Silent	SNP	G	G	A			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr20:44181845G>A	uc002xow.2	-	5	595	c.516C>T	c.(514-516)GAC>GAT	p.D172D	WFDC8_uc002xox.2_Silent_p.D172D	NM_181510	NP_852611	Q8IUA0	WFDC8_HUMAN	WAP four-disulfide core domain 8 precursor	172	WAP 2.					extracellular region	serine-type endopeptidase inhibitor activity				0		Myeloproliferative disorder(115;0.0122)				GACAATCGATGTCACTGTGAC	0.463		NaN											0	0	0	0.00308	0	8	132									
SLC2A10	81031	broad.mit.edu	37	20	45354635	45354635	+	Silent	SNP	C	C	A			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr20:45354635C>A	uc002xsl.2	+	2	1057	c.960C>A	c.(958-960)GCC>GCA	p.A320A		NM_030777	NP_110404	O95528	GTR10_HUMAN	solute carrier family 2 member 10	320	Extracellular (Potential).					endomembrane system|integral to membrane|perinuclear region of cytoplasm|plasma membrane	D-glucose transmembrane transporter activity|sugar:hydrogen symporter activity			ovary(1)	1		Myeloproliferative disorder(115;0.0122)				TCAGCTTTGCCGTGCCCATGG	0.657		NaN											1	0	1.10923e-09	0.00278	1.20906e-09	22	114									
ADRM1	11047	broad.mit.edu	37	20	60882815	60882815	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr20:60882815C>T	uc002ycn.2	+	7	867	c.787C>T	c.(787-789)CAG>TAG	p.Q263*	ADRM1_uc002yco.2_Nonsense_Mutation_p.Q263*	NM_007002	NP_008933	Q16186	ADRM1_HUMAN	adhesion regulating molecule 1 precursor	263					proteasome assembly|transcription elongation from RNA polymerase II promoter	cytoplasm|integral to plasma membrane|membrane fraction|nucleus|proteasome complex	endopeptidase activator activity|protease binding|proteasome binding				0	Breast(26;7.76e-09)		BRCA - Breast invasive adenocarcinoma(19;2.51e-06)			CCAGCCCATCCAGCTGAGCGA	0.677		NaN											0	0	0	0.00308	0	7	41									
EEF1A2	1917	broad.mit.edu	37	20	62120282	62120282	+	Missense_Mutation	SNP	T	T	G			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr20:62120282T>G	uc002yfd.1	-	6	1354	c.1253A>C	c.(1252-1254)TAC>TCC	p.Y418S	EEF1A2_uc002yfe.1_Missense_Mutation_p.Y418S|EEF1A2_uc010gkg.1_Intron	NM_001958	NP_001949	Q05639	EF1A2_HUMAN	eukaryotic translation elongation factor 1 alpha	418						nucleus	GTP binding|GTPase activity|protein binding|translation elongation factor activity				0	all_cancers(38;9.45e-12)		BRCA - Breast invasive adenocarcinoma(10;1.22e-05)			GAGAGGCGGGTACTGGGAGAA	0.667		NaN											0	0	0	0.007835	0	12	43									
MYT1	4661	broad.mit.edu	37	20	62850332	62850332	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr20:62850332C>T	uc002yii.2	+	12	2279	c.1915C>T	c.(1915-1917)CGC>TGC	p.R639C	MYT1_uc002yih.2_Missense_Mutation_p.R341C|MYT1_uc002yij.2_Missense_Mutation_p.R298C	NM_004535	NP_004526	Q01538	MYT1_HUMAN	myelin transcription factor 1	639					cell differentiation|nervous system development	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2	all_cancers(38;1.82e-11)|all_epithelial(29;3.3e-13)|Lung NSC(23;5.21e-10)|all_lung(23;1.92e-09)					CCTCTCCACGCGCTGCTGGGA	0.572		NaN											0	0	0	0.001855	0	14	127									
N6AMT1	29104	broad.mit.edu	37	21	30255351	30255351	+	Silent	SNP	T	T	C			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr21:30255351T>C	uc002ymo.1	-	2	203	c.177A>G	c.(175-177)GTA>GTG	p.V59V	N6AMT1_uc002ymp.1_Silent_p.V59V|N6AMT1_uc002ymq.1_RNA	NM_013240	NP_037372	Q9Y5N5	HEMK2_HUMAN	N-6 adenine-specific DNA methyltransferase 1	59					positive regulation of cell growth	protein complex	nucleic acid binding|protein binding|protein methyltransferase activity				0						GGAATGCAGATACTACACCAG	0.353		NaN											0	0	0	0.001855	0	12	86									
ABCG1	9619	broad.mit.edu	37	21	43704774	43704774	+	Missense_Mutation	SNP	T	T	C			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr21:43704774T>C	uc002zaq.2	+	7	945	c.839T>C	c.(838-840)CTC>CCC	p.L280P	ABCG1_uc002zan.2_Missense_Mutation_p.L282P|ABCG1_uc002zam.2_Missense_Mutation_p.L258P|ABCG1_uc002zao.2_Missense_Mutation_p.L277P|ABCG1_uc002zap.2_Missense_Mutation_p.L280P|ABCG1_uc002zar.2_Missense_Mutation_p.L291P|ABCG1_uc011aev.1_Missense_Mutation_p.L291P|ABCG1_uc010gpb.1_5'Flank	NM_004915	NP_004906	P45844	ABCG1_HUMAN	ATP-binding cassette sub-family G member 1	280	Cytoplasmic (Potential).|ABC transporter.				amyloid precursor protein catabolic process|cholesterol efflux|cholesterol homeostasis|cholesterol metabolic process|detection of hormone stimulus|high-density lipoprotein particle remodeling|intracellular cholesterol transport|lipoprotein metabolic process|low-density lipoprotein particle remodeling|negative regulation of cholesterol storage|negative regulation of macrophage derived foam cell differentiation|phospholipid efflux|phospholipid homeostasis|positive regulation of cholesterol biosynthetic process|regulation of cholesterol esterification|regulation of transcription, DNA-dependent|response to lipid|reverse cholesterol transport	endoplasmic reticulum membrane|external side of plasma membrane|Golgi membrane|recycling endosome	ADP binding|ATP binding|cholesterol transporter activity|glycoprotein transporter activity|phospholipid transporter activity|protein heterodimerization activity|protein homodimerization activity|sterol-transporting ATPase activity|toxin transporter activity			ovary(2)|central_nervous_system(1)	3					Adenosine triphosphate(DB00171)	AGCGCCAAACTCTTCGAGCTG	0.627		NaN											0	0	0	0.008871	0	15	157									
PCNT	5116	broad.mit.edu	37	21	47858159	47858159	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr21:47858159C>T	uc002zji.3	+	41	9289	c.9182C>T	c.(9181-9183)ACG>ATG	p.T3061M	PCNT_uc002zjj.2_Missense_Mutation_p.T2864M	NM_006031	NP_006022	O95613	PCNT_HUMAN	pericentrin	3061	Interaction with NEK2.|Potential.				cilium assembly|G2/M transition of mitotic cell cycle	cytosol|microtubule	calmodulin binding			ovary(4)|breast(2)|pancreas(2)	8	Breast(49;0.112)					GCGCTCAGCACGGTGACCCAG	0.512		NaN											0	0	0	0.00308	0	8	104									
TCN2	6948	broad.mit.edu	37	22	31013431	31013431	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr22:31013431G>A	uc003aip.1	+	7	1213	c.1055G>A	c.(1054-1056)GGG>GAG	p.G352E	TCN2_uc003aiq.1_Missense_Mutation_p.G348E|TCN2_uc003air.1_Missense_Mutation_p.G325E	NM_000355	NP_000346	P20062	TCO2_HUMAN	transcobalamin II precursor	352					cobalamin metabolic process|cobalamin transport|cobalt ion transport	extracellular space	cobalamin binding			central_nervous_system(1)	1					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	GTTCTGGCCGGGTCCACCGTG	0.572		NaN											0	0	0	0.007291	0	30	75									
EFCAB6	64800	broad.mit.edu	37	22	43950813	43950813	+	Missense_Mutation	SNP	G	G	T			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr22:43950813G>T	uc003bdy.1	-	27	3799	c.3584C>A	c.(3583-3585)ACC>AAC	p.T1195N	EFCAB6_uc003bdz.1_Missense_Mutation_p.T1043N|EFCAB6_uc010gzi.1_Missense_Mutation_p.T1043N|EFCAB6_uc010gzj.1_Missense_Mutation_p.T421N	NM_022785	NP_073622	Q5THR3	EFCB6_HUMAN	CAP-binding protein complex interacting protein	1195	EF-hand 13.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	calcium ion binding			ovary(3)|skin(2)|upper_aerodigestive_tract(1)|pancreas(1)	7		Ovarian(80;0.0247)|all_neural(38;0.025)				TCTGGAGATGGTGTTCGTTTT	0.527		NaN											1	0	4.7796e-09	0.004656	5.1787e-09	26	191									
TSEN2	80746	broad.mit.edu	37	3	12571305	12571305	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr3:12571305C>G	uc003bxc.2	+	10	1568	c.1181C>G	c.(1180-1182)TCT>TGT	p.S394C	TSEN2_uc003bwz.2_Missense_Mutation_p.S335C|TSEN2_uc003bxa.2_Missense_Mutation_p.S368C|TSEN2_uc011auq.1_Missense_Mutation_p.S368C|TSEN2_uc003bxb.2_Missense_Mutation_p.S394C|TSEN2_uc011aur.1_Missense_Mutation_p.S303C	NM_025265	NP_079541	Q8NCE0	SEN2_HUMAN	tRNA-intron nuclease 2 isoform 1	394					mRNA processing|tRNA splicing, via endonucleolytic cleavage and ligation	cytoplasm|nucleolus|tRNA-intron endonuclease complex	nucleic acid binding|tRNA-intron endonuclease activity			central_nervous_system(1)	1						TTTGAAGGCTCTCTCCGCAGG	0.403		NaN											0	0	0	0.00361	0	56	120									
ZNF445	353274	broad.mit.edu	37	3	44490077	44490077	+	Silent	SNP	C	C	T			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr3:44490077C>T	uc003cnf.2	-	8	1434	c.1086G>A	c.(1084-1086)AAG>AAA	p.K362K	ZNF445_uc011azv.1_Silent_p.K350K|ZNF445_uc011azw.1_Silent_p.K362K	NM_181489	NP_852466	P59923	ZN445_HUMAN	zinc finger protein 445	362					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1				KIRC - Kidney renal clear cell carcinoma(197;0.0514)|Kidney(197;0.0646)		CACATTGATCCTTCTGCCTGC	0.418		NaN											0	0	0	0.004007	0	16	80									
WDR82	80335	broad.mit.edu	37	3	52294439	52294439	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr3:52294439C>T	uc003ddl.2	-	5	787	c.505G>A	c.(505-507)GAA>AAA	p.E169K	WDR82_uc003ddk.2_Missense_Mutation_p.E94K	NM_025222	NP_079498	Q6UXN9	WDR82_HUMAN	WD repeat domain 82	169	WD 3.				histone H3-K4 methylation	chromatin|PTW/PP1 phosphatase complex|Set1C/COMPASS complex	protein binding				0				BRCA - Breast invasive adenocarcinoma(193;2.67e-05)|Kidney(197;0.00198)|KIRC - Kidney renal clear cell carcinoma(197;0.00223)|OV - Ovarian serous cystadenocarcinoma(275;0.246)		TTGACCATTTCAGAGTTGACA	0.338		NaN											0	0	0	0.003163	0	15	47									
DNAH1	25981	broad.mit.edu	37	3	52398863	52398863	+	Silent	SNP	C	C	G			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr3:52398863C>G	uc011bef.1	+	34	5607	c.5346C>G	c.(5344-5346)CTC>CTG	p.L1782L		NM_015512	NP_056327	Q9P2D7	DYH1_HUMAN	dynein, axonemal, heavy chain 1	1782					ciliary or flagellar motility|microtubule-based movement|response to mechanical stimulus	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			large_intestine(3)	3				BRCA - Breast invasive adenocarcinoma(193;2.02e-05)|OV - Ovarian serous cystadenocarcinoma(275;0.000207)|Kidney(197;0.0022)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		TGATCTGCCTCCGGGCCATCC	0.637		NaN											0	0	0	0.004007	0	16	51									
GNL3	26354	broad.mit.edu	37	3	52725636	52725636	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr3:52725636G>A	uc003dfd.2	+	9	1033	c.860G>A	c.(859-861)GGG>GAG	p.G287E	GNL3_uc003dfe.2_Missense_Mutation_p.G275E|GNL3_uc003dff.2_Missense_Mutation_p.G275E|SNORD69_uc003dfh.1_5'Flank	NM_014366	NP_055181	Q9BVP2	GNL3_HUMAN	guanine nucleotide binding protein-like 3	287	G.|Intermediate (By similarity).				regulation of cell proliferation	nucleolus	GTP binding|protein binding				0				BRCA - Breast invasive adenocarcinoma(193;6.75e-05)|Kidney(197;0.000611)|KIRC - Kidney renal clear cell carcinoma(197;0.000773)|OV - Ovarian serous cystadenocarcinoma(275;0.048)		GTATCCATGGGGCTTACAAGG	0.323		NaN											0	0	0	0.001168	0	5	31									
ACOX2	8309	broad.mit.edu	37	3	58519231	58519231	+	Missense_Mutation	SNP	G	G	T			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr3:58519231G>T	uc003dkl.2	-	5	699	c.524C>A	c.(523-525)ACC>AAC	p.T175N		NM_003500	NP_003491	Q99424	ACOX2_HUMAN	acyl-Coenzyme A oxidase 2	175					bile acid biosynthetic process|fatty acid beta-oxidation using acyl-CoA oxidase	peroxisomal matrix	3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA 24-hydroxylase activity|acyl-CoA dehydrogenase activity|pristanoyl-CoA oxidase activity				0				BRCA - Breast invasive adenocarcinoma(55;0.000194)|Kidney(10;0.00255)|KIRC - Kidney renal clear cell carcinoma(10;0.00268)|OV - Ovarian serous cystadenocarcinoma(275;0.156)		AAACTCCTGGGTGGCTGCGTC	0.542		NaN									OREG0015638	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	1	0	2.80697e-09	0.010729	3.04741e-09	10	144									
FOXP1	27086	broad.mit.edu	37	3	71050168	71050168	+	Silent	SNP	G	G	T			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr3:71050168G>T	uc003dol.2	-	9	1340	c.1017C>A	c.(1015-1017)GCC>GCA	p.A339A	FOXP1_uc003dom.2_Silent_p.A263A|FOXP1_uc003don.2_RNA|FOXP1_uc003doo.2_Silent_p.A339A|FOXP1_uc003dop.2_Silent_p.A339A|FOXP1_uc003doq.1_Silent_p.A338A|FOXP1_uc003doi.2_Silent_p.A239A|FOXP1_uc003doj.2_Silent_p.A239A|FOXP1_uc003dok.2_Silent_p.A152A|FOXP1_uc003dor.1_Silent_p.A117A	NM_032682	NP_116071	Q9H334	FOXP1_HUMAN	forkhead box P1 isoform 1	339					cardiac muscle cell differentiation|embryo development|immunoglobulin V(D)J recombination|pattern specification process|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of immunoglobulin production|positive regulation of mesenchymal cell proliferation|pre-B cell differentiation|regulation of sequence-specific DNA binding transcription factor activity|skeletal muscle tissue development|smooth muscle tissue development	cytoplasm|transcription factor complex	chromatin binding|DNA bending activity|double-stranded DNA binding|promoter binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|zinc ion binding			ovary(1)|lung(1)	2		Lung NSC(201;4.62e-05)|Prostate(10;0.0181)|Hepatocellular(537;0.186)|Myeloproliferative disorder(1037;0.209)		BRCA - Breast invasive adenocarcinoma(55;1.17e-05)|Epithelial(33;1.39e-05)|LUSC - Lung squamous cell carcinoma(21;2.35e-05)|Lung(16;4.26e-05)		CTCTACATTGGGCTGTACTTC	0.353		NaN	T	PAX5	ALL								1	0	0.00741294	0.007413	0.00756564	17	74									
DPPA2	151871	broad.mit.edu	37	3	109027098	109027098	+	Missense_Mutation	SNP	A	A	C			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr3:109027098A>C	uc003dxo.2	-	6	686	c.439T>G	c.(439-441)TCG>GCG	p.S147A		NM_138815	NP_620170	Q7Z7J5	DPPA2_HUMAN	developmental pluripotency associated 2	147						nucleus	nucleic acid binding			ovary(2)|upper_aerodigestive_tract(1)	3						CGTTTCCTCGAACATCGCTGT	0.433		NaN											0	0	0	0.001368	0	13	116									
SIDT1	54847	broad.mit.edu	37	3	113303564	113303564	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr3:113303564G>C	uc003eak.2	+	8	1506	c.855G>C	c.(853-855)TGG>TGC	p.W285C	SIDT1_uc011bif.1_RNA|SIDT1_uc003eaj.1_Missense_Mutation_p.W285C|SIDT1_uc011big.1_Missense_Mutation_p.W38C	NM_017699	NP_060169	Q9NXL6	SIDT1_HUMAN	SID1 transmembrane family, member 1 precursor	285	Extracellular (Potential).					integral to membrane				ovary(3)|pancreas(1)|skin(1)	5						ACCAGACCTGGAATCTACAGC	0.358		NaN											0	0	0	0.001368	0	10	96									
IGSF11	152404	broad.mit.edu	37	3	118623621	118623621	+	Missense_Mutation	SNP	A	A	G			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr3:118623621A>G	uc003ebw.2	-	6	975	c.728T>C	c.(727-729)ATA>ACA	p.I243T	IGSF11_uc011biv.1_Intron|IGSF11_uc003ebx.2_Missense_Mutation_p.I219T|IGSF11_uc003eby.2_Missense_Mutation_p.I242T|IGSF11_uc003ebz.2_Missense_Mutation_p.I218T|IGSF11_uc010hqs.2_Missense_Mutation_p.I242T	NM_001015887	NP_001015887	Q5DX21	IGS11_HUMAN	immunoglobulin superfamily, member 11 isoform b	243	Helical; (Potential).				cell adhesion|regulation of growth	integral to membrane|plasma membrane	receptor activity				0						GGCTCCAGCTATTAGTCCAAT	0.358		NaN											0	0	0	0.00361	0	59	248									
KALRN	8997	broad.mit.edu	37	3	124436142	124436142	+	Silent	SNP	G	G	A			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr3:124436142G>A	uc003ehg.2	+	59	8452	c.8325G>A	c.(8323-8325)CTG>CTA	p.L2775L	KALRN_uc003ehk.2_Silent_p.L1078L	NM_001024660	NP_001019831	O60229	KALRN_HUMAN	kalirin, RhoGEF kinase isoform 1	2774	Protein kinase.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|vesicle-mediated transport	actin cytoskeleton|cytosol	ATP binding|GTPase activator activity|metal ion binding|protein binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			large_intestine(2)|ovary(2)|central_nervous_system(1)|skin(1)	6						ATGATGAACTGATGGAGGAAA	0.413		NaN											0	0	0	0.00361	0	71	82									
UROC1	131669	broad.mit.edu	37	3	126208204	126208204	+	Silent	SNP	C	C	T			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr3:126208204C>T	uc003eiz.1	-	17	1655	c.1623G>A	c.(1621-1623)CTG>CTA	p.L541L	UROC1_uc010hsi.1_Silent_p.L601L	NM_144639	NP_653240	Q96N76	HUTU_HUMAN	urocanase domain containing 1 isoform 1	541					histidine catabolic process	cytosol	urocanate hydratase activity			ovary(1)	1				GBM - Glioblastoma multiforme(114;0.17)		GATCTCGGCTCAGGACCACCG	0.582		NaN											0	0	0	0.00361	0	87	148									
PLXNA1	5361	broad.mit.edu	37	3	126707544	126707544	+	Silent	SNP	T	T	G			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr3:126707544T>G	uc003ejg.2	+	1	43	c.39T>G	c.(37-39)GGT>GGG	p.G13G		NM_032242	NP_115618	Q9UIW2	PLXA1_HUMAN	plexin A1	36	Sema.|Extracellular (Potential).				axon guidance	integral to membrane|intracellular|plasma membrane	semaphorin receptor activity			ovary(1)|pancreas(1)|skin(1)	3				GBM - Glioblastoma multiforme(114;0.155)		CAGGCGGGGGTTCACAGCCCC	0.567		NaN											0	0	0	0.00632	0	10	32									
ACAD11	84129	broad.mit.edu	37	3	132337486	132337486	+	Missense_Mutation	SNP	T	T	C			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr3:132337486T>C	uc003eov.3	-	11	1786	c.1406A>G	c.(1405-1407)CAA>CGA	p.Q469R	ACAD11_uc011blr.1_Missense_Mutation_p.Q80R|ACAD11_uc003eoy.2_Missense_Mutation_p.Q469R	NM_032169	NP_115545	Q709F0	ACD11_HUMAN	putative acyl-CoA dehydrogenase	469						peroxisome	acyl-CoA dehydrogenase activity|flavin adenine dinucleotide binding|transferase activity, transferring phosphorus-containing groups			ovary(1)	1						ACCTGGTGCTTGGCAGTTAAA	0.338		NaN											0	0	0	0.003163	0	15	75									
RAB6B	51560	broad.mit.edu	37	3	133614257	133614257	+	Missense_Mutation	SNP	G	G	T			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr3:133614257G>T	uc003epy.2	-	1	435	c.54C>A	c.(52-54)TTC>TTA	p.F18L	RAB6B_uc011blu.1_5'UTR	NM_016577	NP_057661	Q9NRW1	RAB6B_HUMAN	RAB6B, member RAS oncogene family	18					protein transport|retrograde vesicle-mediated transport, Golgi to ER|small GTPase mediated signal transduction	cytoplasmic membrane-bounded vesicle|Golgi membrane	GTP binding|GTPase activity|protein binding			pancreas(1)	1						GCTCCCCCAAGAACACCAACT	0.507		NaN											1	0	7.25294e-45	0.00361	8.46435e-45	68	60									
ZIC4	84107	broad.mit.edu	37	3	147113765	147113765	+	Missense_Mutation	SNP	T	T	G			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr3:147113765T>G	uc003ewd.1	-	3	835	c.562A>C	c.(562-564)AAA>CAA	p.K188Q	ZIC4_uc003ewc.1_Missense_Mutation_p.K118Q|ZIC4_uc011bno.1_Missense_Mutation_p.K238Q	NM_032153	NP_115529	Q8N9L1	ZIC4_HUMAN	zinc finger protein of the cerebellum 4	188	C2H2-type 2; atypical.					nucleus	DNA binding|zinc ion binding			upper_aerodigestive_tract(1)|central_nervous_system(1)	2						AGTTTGTATTTGGCTTTGAAG	0.572		NaN											0	0	0	0.010818	0	30	367									
PLCH1	23007	broad.mit.edu	37	3	155208658	155208658	+	Splice_Site	SNP	C	C	G			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr3:155208658C>G	uc011bok.1	-	18	2549	c.2272_splice	c.e18-1	p.I758_splice	PLCH1_uc011boj.1_Splice_Site_p.I758_splice|PLCH1_uc011bol.1_Splice_Site_p.I740_splice	NM_001130960	NP_001124432	Q4KWH8	PLCH1_HUMAN	phospholipase C eta 1 isoform a						lipid catabolic process|phosphatidylinositol-mediated signaling	membrane	calcium ion binding|calcium-dependent phospholipase C activity|phosphatidylinositol phospholipase C activity|signal transducer activity			skin(3)|ovary(1)	4			Lung(72;0.11)|LUSC - Lung squamous cell carcinoma(72;0.114)			GGTCAATGATCTATTAAGTAA	0.313		NaN											0	0	0	0.001168	0	6	48									
ECT2	1894	broad.mit.edu	37	3	172472376	172472376	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr3:172472376C>G	uc003fii.2	+	2	194	c.56C>G	c.(55-57)TCT>TGT	p.S19C	ECT2_uc010hwv.1_Missense_Mutation_p.S19C|ECT2_uc003fih.2_Missense_Mutation_p.S19C|ECT2_uc003fij.1_Missense_Mutation_p.S19C|ECT2_uc003fik.1_Missense_Mutation_p.S19C|ECT2_uc003fil.1_Missense_Mutation_p.S19C	NM_018098	NP_060568	Q9H8V3	ECT2_HUMAN	epithelial cell transforming sequence 2 oncogene	19					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity|signal transducer activity			breast(2)|ovary(1)|skin(1)	4	Ovarian(172;0.00197)|Breast(254;0.158)		Lung(28;1.33e-14)|LUSC - Lung squamous cell carcinoma(14;1.48e-14)			TTGGCAGACTCTTCCATTTTT	0.323		NaN											0	0	0	0.001368	0	13	17									
ECT2	1894	broad.mit.edu	37	3	172472419	172472419	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr3:172472419C>G	uc003fii.2	+	2	237	c.99C>G	c.(97-99)AAC>AAG	p.N33K	ECT2_uc010hwv.1_Missense_Mutation_p.N33K|ECT2_uc003fih.2_Missense_Mutation_p.N33K|ECT2_uc003fij.1_Missense_Mutation_p.N33K|ECT2_uc003fik.1_Missense_Mutation_p.N33K|ECT2_uc003fil.1_Missense_Mutation_p.N33K	NM_018098	NP_060568	Q9H8V3	ECT2_HUMAN	epithelial cell transforming sequence 2 oncogene	33					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity|signal transducer activity			breast(2)|ovary(1)|skin(1)	4	Ovarian(172;0.00197)|Breast(254;0.158)		Lung(28;1.33e-14)|LUSC - Lung squamous cell carcinoma(14;1.48e-14)			CCAAGGAAAACTTACTTATTG	0.323		NaN											0	0	0	0.00499	0	17	15									
ABCC5	10057	broad.mit.edu	37	3	183670874	183670874	+	Silent	SNP	C	C	T			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr3:183670874C>T	uc003fmg.2	-	18	2832	c.2667G>A	c.(2665-2667)GGG>GGA	p.G889G	ABCC5_uc011bqt.1_Silent_p.G417G|ABCC5_uc010hxl.2_Silent_p.G889G	NM_005688	NP_005679	O15440	MRP5_HUMAN	ATP-binding cassette, sub-family C, member 5	889	ABC transmembrane type-1 2.					integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of substances|organic anion transmembrane transporter activity			ovary(2)|large_intestine(1)|central_nervous_system(1)	4	all_cancers(143;1.85e-10)|Ovarian(172;0.0303)		Epithelial(37;1.74e-35)|OV - Ovarian serous cystadenocarcinoma(80;6.48e-22)			GTAACCTTACCCCGCTTCCTT	0.463		NaN											0	0	0	0.00361	0	57	109									
THPO	7066	broad.mit.edu	37	3	184090596	184090596	+	Missense_Mutation	SNP	C	C	A			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr3:184090596C>A	uc003fol.1	-	6	982	c.767G>T	c.(766-768)GGA>GTA	p.G256V	THPO_uc003fom.1_Missense_Mutation_p.G252V|THPO_uc003fon.2_Missense_Mutation_p.W217C|THPO_uc011bro.1_Intron|THPO_uc003fop.2_Missense_Mutation_p.W213C|THPO_uc011brp.1_Intron|THPO_uc011brq.1_Missense_Mutation_p.W177C	NM_000460	NP_000451	P40225	TPO_HUMAN	thrombopoietin precursor	256					cell proliferation|platelet activation	extracellular space	cytokine activity|growth factor activity|hormone activity			ovary(1)	1	all_cancers(143;6.33e-11)|Ovarian(172;0.0339)		Epithelial(37;4.96e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			TCCACGAGTTCCATTCAAGAG	0.562		NaN											1	0	2.60632e-51	0.00361	3.04816e-51	91	286									
DGKG	1608	broad.mit.edu	37	3	186015941	186015941	+	Silent	SNP	G	G	A			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr3:186015941G>A	uc003fqa.2	-	4	759	c.222C>T	c.(220-222)CAC>CAT	p.H74H	DGKG_uc003fqb.2_Silent_p.H74H|DGKG_uc003fqc.2_Silent_p.H74H|DGKG_uc011brx.1_Silent_p.H74H	NM_001346	NP_001337	P49619	DGKG_HUMAN	diacylglycerol kinase gamma isoform 1	74					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	cytoplasm|plasma membrane	ATP binding|calcium ion binding|diacylglycerol kinase activity			breast(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	5	all_cancers(143;3.26e-12)|Ovarian(172;0.0315)|Breast(254;0.247)		OV - Ovarian serous cystadenocarcinoma(80;1.93e-20)	GBM - Glioblastoma multiforme(93;0.0657)	Phosphatidylserine(DB00144)	CCAGGAAGAGGTGAGTGCTCA	0.527		NaN											0	0	0	0.009535	0	33	211									
FGFR3	2261	broad.mit.edu	37	4	1806099	1806099	+	Missense_Mutation	SNP	A	A	G	rs121913485		TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08			A	G	A	A		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr4:1806099A>G	uc003gdr.3	+	9	1374	c.1118A>G	c.(1117-1119)TAT>TGT	p.Y373C	FGFR3_uc003gdu.2_Missense_Mutation_p.Y375C|FGFR3_uc003gds.3_Intron|FGFR3_uc003gdq.3_Missense_Mutation_p.Y373C	NM_000142	NP_000133	P22607	FGFR3_HUMAN	fibroblast growth factor receptor 3 isoform 1	373	Extracellular (Potential).		Y -> C (in KERSEB and TD1).		bone maturation|cell growth|insulin receptor signaling pathway|JAK-STAT cascade|MAPKKK cascade|negative regulation of developmental growth|positive regulation of cell proliferation	integral to plasma membrane	ATP binding|fibroblast growth factor binding|fibroblast growth factor receptor activity|identical protein binding	p.Y373C(437)		urinary_tract(2177)|skin(314)|upper_aerodigestive_tract(57)|haematopoietic_and_lymphoid_tissue(24)|prostate(9)|cervix(6)|central_nervous_system(4)|large_intestine(3)|lung(3)|testis(2)|pancreas(1)	2600		Breast(71;0.212)|all_epithelial(65;0.241)	all cancers(2;0.000145)|OV - Ovarian serous cystadenocarcinoma(23;0.0019)|Epithelial(3;0.00221)|GBM - Glioblastoma multiforme(2;0.234)		Palifermin(DB00039)	GGCAGTGTGTATGCAGGCATC	0.682	Y373C(KMS11_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)	1	Mis|T	IGH@|ETV6	bladder|MM|T-cell lymphoma		Hypochondroplasia|Thanatophoric dysplasia		Muenke_syndrome|Saethre-Chotzen_syndrome				0	0	0	0.00361	0	159	67									
C1QTNF7	114905	broad.mit.edu	37	4	15437374	15437374	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr4:15437374G>C	uc011bxb.1	+	2	234	c.7G>C	c.(7-9)GTC>CTC	p.V3L	C1QTNF7_uc003gno.2_Missense_Mutation_p.V10L|C1QTNF7_uc003gnp.2_Missense_Mutation_p.V3L	NM_001135171	NP_001128643	Q9BXJ2	C1QT7_HUMAN	C1q and tumor necrosis factor related protein 7	3						collagen					0						AAAGATGTTTGTCTTGCTCTA	0.448		NaN											0	0	0	0.009096	0	4	68									
CD38	952	broad.mit.edu	37	4	15780060	15780060	+	Missense_Mutation	SNP	C	C	A	rs78988986	byFrequency	TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr4:15780060C>A	uc011bxc.1	+	1	130	c.23C>A	c.(22-24)CCG>CAG	p.P8Q	CD38_uc003goj.1_Missense_Mutation_p.P8Q|CD38_uc003gol.1_Missense_Mutation_p.P8Q	NM_001775	NP_001766	P28907	CD38_HUMAN	CD38 antigen	8	Cytoplasmic (Potential).				B cell receptor signaling pathway|induction of apoptosis by extracellular signals|negative regulation of apoptosis|negative regulation of transcription, DNA-dependent|positive regulation of B cell proliferation|positive regulation of transcription, DNA-dependent|response to drug	integral to membrane|plasma membrane	binding|NAD+ nucleosidase activity|receptor activity			ovary(2)	2						GAGTTCAGCCCGGTGTCCGGG	0.647		NaN											1	0	5.20006e-24	0.011902	5.89196e-24	43	96									
SLC34A2	10568	broad.mit.edu	37	4	25677816	25677816	+	Silent	SNP	G	G	A			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr4:25677816G>A	uc003grr.2	+	13	1599	c.1518G>A	c.(1516-1518)CCG>CCA	p.P506P	SLC34A2_uc003grs.2_Silent_p.P505P|SLC34A2_uc010iev.2_Silent_p.P505P	NM_006424	NP_006415	O95436	NPT2B_HUMAN	solute carrier family 34 (sodium phosphate),	506	Helical; Name=M6; (Potential).				cellular phosphate ion homeostasis	apical plasma membrane|brush border membrane|integral to plasma membrane	phosphate binding|sodium ion binding|sodium-dependent phosphate transmembrane transporter activity|sodium:phosphate symporter activity			skin(3)|ovary(1)|kidney(1)	5		Breast(46;0.0503)				ACCCGATCCCGTTCACTCGCC	0.567		NaN											0	0	0	0.012213	0	34	121									
DCAF4L1	285429	broad.mit.edu	37	4	41984468	41984468	+	Nonsense_Mutation	SNP	C	C	G			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr4:41984468C>G	uc003gwk.2	+	1	756	c.659C>G	c.(658-660)TCA>TGA	p.S220*		NM_001029955	NP_001025126	Q3SXM0	DC4L1_HUMAN	WD repeat domain 21B	220										skin(1)	1						CACCAGCAGTCATTTGATACC	0.552		NaN											0	0	0	0.00361	0	70	262									
GABRB1	2560	broad.mit.edu	37	4	47033934	47033934	+	Silent	SNP	C	C	T			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr4:47033934C>T	uc003gxh.2	+	2	458	c.84C>T	c.(82-84)ACC>ACT	p.T28T	GABRB1_uc011bze.1_5'UTR|GABRB1_uc011bzd.1_Silent_p.T28T|GABRB1_uc010igg.2_RNA	NM_000812	NP_000803	P18505	GBRB1_HUMAN	gamma-aminobutyric acid (GABA) A receptor, beta	28	Extracellular (Probable).				synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			ovary(2)	2					Ethchlorvynol(DB00189)|Flurazepam(DB00690)|Lorazepam(DB00186)|Midazolam(DB00683)	CCCTTAGCACCAATGAACCCA	0.458		NaN											0	0	0	0.00278	0	21	258									
SCD5	79966	broad.mit.edu	37	4	83557961	83557961	+	Silent	SNP	G	G	A			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr4:83557961G>A	uc003hna.2	-	4	905	c.585C>T	c.(583-585)TCC>TCT	p.S195S		NM_001037582	NP_001032671	Q86SK9	SCD5_HUMAN	stearoyl-CoA desaturase 5 isoform a	195	Helical; (Potential).				fatty acid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	iron ion binding|stearoyl-CoA 9-desaturase activity			ovary(1)	1		Colorectal(4;0.0323)|Hepatocellular(203;0.115)				TGAGCACCACGGAGATCTTAT	0.517		NaN											0	0	0	0.010504	0	21	19									
WDFY3	23001	broad.mit.edu	37	4	85672647	85672647	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr4:85672647G>C	uc003hpd.2	-	36	6370	c.5962C>G	c.(5962-5964)CTT>GTT	p.L1988V		NM_014991	NP_055806	Q8IZQ1	WDFY3_HUMAN	WD repeat and FYVE domain containing 3 isoform	1988						cytoplasmic part|extrinsic to membrane|nuclear envelope	1-phosphatidylinositol binding|metal ion binding|protein binding			ovary(2)|central_nervous_system(1)	3		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000808)		TCCAACAAAAGATCAATTAGT	0.358		NaN											0	0	0	0.00245	0	14	72									
WDFY3	23001	broad.mit.edu	37	4	85672677	85672677	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr4:85672677G>C	uc003hpd.2	-	36	6340	c.5932C>G	c.(5932-5934)CCT>GCT	p.P1978A		NM_014991	NP_055806	Q8IZQ1	WDFY3_HUMAN	WD repeat and FYVE domain containing 3 isoform	1978						cytoplasmic part|extrinsic to membrane|nuclear envelope	1-phosphatidylinositol binding|metal ion binding|protein binding			ovary(2)|central_nervous_system(1)	3		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000808)		TTGCTGGCAGGAGTGAGACAG	0.388		NaN											0	0	0	0.003163	0	14	90									
KLHL8	57563	broad.mit.edu	37	4	88097923	88097923	+	Silent	SNP	T	T	G			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr4:88097923T>G	uc011cdb.1	-	6	1579	c.1194A>C	c.(1192-1194)TCA>TCC	p.S398S	KLHL8_uc003hql.1_Silent_p.S398S|KLHL8_uc003hqm.1_Silent_p.S322S|KLHL8_uc003hqn.1_Silent_p.S215S|KLHL8_uc010ikj.1_Silent_p.S47S	NM_020803	NP_065854	Q9P2G9	KLHL8_HUMAN	kelch-like 8	398	Kelch 2.										0		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.242)		OV - Ovarian serous cystadenocarcinoma(123;0.000603)		TTGTGTTCATTGATGCCTTCA	0.338		NaN											0	0	0	0.012319	0	22	65									
AGXT2L1	64850	broad.mit.edu	37	4	109663675	109663675	+	Missense_Mutation	SNP	T	T	G			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr4:109663675T>G	uc003hzc.2	-	13	1646	c.1465A>C	c.(1465-1467)ACA>CCA	p.T489P	AGXT2L1_uc010imc.2_Missense_Mutation_p.T483P|AGXT2L1_uc011cfm.1_Missense_Mutation_p.T449P|AGXT2L1_uc011cfn.1_Missense_Mutation_p.T416P|AGXT2L1_uc011cfo.1_Missense_Mutation_p.T431P	NM_031279	NP_112569	Q8TBG4	AT2L1_HUMAN	alanine-glyoxylate aminotransferase 2-like 1	489					cellular amino acid metabolic process	mitochondrion	alanine-glyoxylate transaminase activity|pyridoxal phosphate binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(123;0.000281)		AGTGAATGTGTATCCGTGCAC	0.438		NaN											0	0	0	0.00499	0	16	127									
SYNPO2	171024	broad.mit.edu	37	4	119951548	119951548	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr4:119951548G>C	uc003icm.3	+	4	1814	c.1618G>C	c.(1618-1620)GAG>CAG	p.E540Q	SYNPO2_uc010ina.2_Missense_Mutation_p.E540Q|SYNPO2_uc010inb.2_Missense_Mutation_p.E540Q|SYNPO2_uc011cgh.1_Intron|SYNPO2_uc010inc.2_Missense_Mutation_p.E468Q	NM_001128933	NP_001122405	Q9UMS6	SYNP2_HUMAN	synaptopodin 2 isoform b	540						nucleus|Z disc	14-3-3 protein binding|actin binding|muscle alpha-actinin binding			ovary(2)	2						CCAAAGAAAGGAGGAAGAGTC	0.517		NaN											0	0	0	0.00361	0	53	54									
SPATA5	166378	broad.mit.edu	37	4	123855676	123855676	+	Silent	SNP	A	A	G	rs141742510	by1000genomes	TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr4:123855676A>G	uc003iez.3	+	5	1003	c.930A>G	c.(928-930)CTA>CTG	p.L310L	SPATA5_uc003iey.2_Silent_p.L309L	NM_145207	NP_660208	Q8NB90	SPAT5_HUMAN	spermatogenesis associated 5	310					cell differentiation|multicellular organismal development|spermatogenesis	mitochondrion	ATP binding|nucleoside-triphosphatase activity				0						AGAGACTGCTAAAGTTCAGCA	0.348		NaN											0	0	0	0.00245	0	14	64									
UCP1	7350	broad.mit.edu	37	4	141489011	141489011	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr4:141489011G>A	uc011chj.1	-	2	323	c.247C>T	c.(247-249)CAG>TAG	p.Q83*	UCP1_uc011chk.1_Nonsense_Mutation_p.Q83*	NM_021833	NP_068605	P25874	UCP1_HUMAN	uncoupling protein 1	83	Solcar 1.|Helical; Name=2; (Potential).				brown fat cell differentiation|cellular lipid metabolic process|respiratory electron transport chain	integral to membrane|mitochondrial inner membrane	binding			ovary(1)	1	all_hematologic(180;0.162)					ATTTGCCGCTGAAGCCCCGCA	0.562		NaN											0	0	0	0.00632	0	28	136									
TBC1D9	23158	broad.mit.edu	37	4	141600892	141600892	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr4:141600892C>G	uc010ioj.2	-	4	738	c.466G>C	c.(466-468)GAG>CAG	p.E156Q		NM_015130	NP_055945	Q6ZT07	TBCD9_HUMAN	TBC1 domain family, member 9 (with GRAM domain)	156	GRAM 1.					intracellular	calcium ion binding|Rab GTPase activator activity			ovary(1)	1	all_hematologic(180;0.162)	Medulloblastoma(177;0.00498)				TTCTCTTCCTCTGGCATCCCA	0.423		NaN											0	0	0	0.007413	0	18	25									
EDNRA	1909	broad.mit.edu	37	4	148406949	148406949	+	Missense_Mutation	SNP	C	C	A			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr4:148406949C>A	uc003iky.2	+	2	808	c.116C>A	c.(115-117)ACT>AAT	p.T39N	EDNRA_uc011cid.1_Intron|EDNRA_uc010ipe.1_Missense_Mutation_p.T39N|EDNRA_uc010ipf.1_RNA|EDNRA_uc010ipg.1_Missense_Mutation_p.T39N	NM_001957	NP_001948	P25101	EDNRA_HUMAN	endothelin receptor type A isoform a precursor	39	Extracellular (Potential).				activation of adenylate cyclase activity|artery smooth muscle contraction|cell proliferation|glucose transport|respiratory gaseous exchange	integral to plasma membrane	endothelin-A receptor activity|phosphatidylinositol phospholipase C activity			ovary(1)|breast(1)	2	all_hematologic(180;0.151)			GBM - Glioblastoma multiforme(119;0.154)	Bosentan(DB00559)	GATTTCACCACTTTTCGTGGC	0.473		NaN											1	0	1.04594e-18	0.00623	1.17533e-18	41	65									
RAPGEF2	9693	broad.mit.edu	37	4	160271403	160271403	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr4:160271403C>G	uc003iqg.3	+	20	3654	c.3344C>G	c.(3343-3345)TCT>TGT	p.S1115C		NM_014247	NP_055062	Q9Y4G8	RPGF2_HUMAN	Rap guanine nucleotide exchange factor 2	1115	Ser-rich.				cAMP-mediated signaling|MAPKKK cascade|small GTPase mediated signal transduction	integral to plasma membrane|intracellular	calcium ion binding|diacylglycerol binding|Rap GTPase activator activity|Rap guanyl-nucleotide exchange factor activity|signal transducer activity			lung(2)|upper_aerodigestive_tract(1)|skin(1)	4	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.0817)		TCGCAGCTTTCTTCTCCTCCT	0.333		NaN											0	0	0	0.010729	0	10	29									
SPATA4	132851	broad.mit.edu	37	4	177116553	177116553	+	Missense_Mutation	SNP	G	G	T			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr4:177116553G>T	uc003iuo.1	-	1	270	c.161C>A	c.(160-162)TCC>TAC	p.S54Y		NM_144644	NP_653245	Q8NEY3	SPAT4_HUMAN	spermatogenesis associated 4	54					apoptosis|spermatogenesis						0		Breast(14;0.0011)|Prostate(90;0.0129)|Melanoma(52;0.0133)|Renal(120;0.0376)|all_hematologic(60;0.124)		all cancers(43;2.9e-20)|Epithelial(43;1.99e-17)|OV - Ovarian serous cystadenocarcinoma(60;2.58e-09)|GBM - Glioblastoma multiforme(59;0.000162)|STAD - Stomach adenocarcinoma(60;0.000543)|LUSC - Lung squamous cell carcinoma(193;0.096)		ACGCAGAACGGAACGAGACAA	0.607		NaN											1	0	2.97807e-44	0.00361	3.46805e-44	73	91									
ING2	3622	broad.mit.edu	37	4	184431737	184431737	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr4:184431737G>A	uc003ivs.1	+	2	604	c.475G>A	c.(475-477)GAA>AAA	p.E159K	ING2_uc011ckk.1_Missense_Mutation_p.E119K	NM_001564	NP_001555	Q9H160	ING2_HUMAN	inhibitor of growth family, member 2	159					chromatin modification|positive regulation of transcription, DNA-dependent|positive regulation of transforming growth factor beta receptor signaling pathway|regulation of growth|signal transduction|transcription, DNA-dependent	CCAAT-binding factor complex|Sin3 complex	chromatin binding|DNA binding|protein complex binding|zinc ion binding			ovary(1)	1		all_lung(41;5.16e-14)|Lung NSC(41;1.33e-13)|Colorectal(36;0.00139)|Hepatocellular(41;0.00886)|Renal(120;0.00988)|all_hematologic(60;0.0207)|Prostate(90;0.0235)|all_neural(102;0.202)		all cancers(43;1.15e-26)|Epithelial(43;2.98e-22)|OV - Ovarian serous cystadenocarcinoma(60;7.64e-10)|GBM - Glioblastoma multiforme(59;4.22e-06)|Colorectal(24;5.87e-06)|STAD - Stomach adenocarcinoma(60;2.09e-05)|COAD - Colon adenocarcinoma(29;5.15e-05)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.155)		GCGGACCAGTGAAAGCCGTGA	0.458		NaN											0	0	0	0.005524	0	38	48									
CDH18	1016	broad.mit.edu	37	5	19473804	19473804	+	Missense_Mutation	SNP	G	G	A	rs147821413		TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr5:19473804G>A	uc003jgc.2	-	12	2281	c.1904C>T	c.(1903-1905)ACC>ATC	p.T635I	CDH18_uc003jgd.2_Missense_Mutation_p.T635I|CDH18_uc011cnm.1_3'UTR	NM_004934	NP_004925	Q13634	CAD18_HUMAN	cadherin 18, type 2 preproprotein	635	Helical; (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(5)|large_intestine(1)|skin(1)	7	Lung NSC(1;0.00734)|all_lung(1;0.0197)					GCGCCTCAGGGTGATAAAAAG	0.423		NaN											0	0	0	0.007291	0	30	301									
AMACR	23600	broad.mit.edu	37	5	33989503	33989503	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr5:33989503C>T	uc003jig.2	-	5	926	c.844G>A	c.(844-846)GAG>AAG	p.E282K	AMACR_uc003jih.2_3'UTR|AMACR_uc003jii.2_Missense_Mutation_p.E267K|AMACR_uc003jij.2_Missense_Mutation_p.E282K	NM_014324	NP_055139	Q9UHK6	AMACR_HUMAN	alpha-methylacyl-CoA racemase isoform 1	282					bile acid biosynthetic process|fatty acid beta-oxidation using acyl-CoA oxidase	mitochondrion|peroxisomal matrix	alpha-methylacyl-CoA racemase activity				0						TGACACCACTCTGCCTTCGTC	0.458		NaN											0	0	0	0.00361	0	63	83									
C5orf42	65250	broad.mit.edu	37	5	37169135	37169135	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr5:37169135C>T	uc011cpa.1	-	34	7222	c.6991G>A	c.(6991-6993)GAC>AAC	p.D2331N	C5orf42_uc011coy.1_Missense_Mutation_p.D831N|C5orf42_uc003jks.2_RNA|C5orf42_uc011coz.1_Missense_Mutation_p.D1406N|C5orf42_uc003jkr.1_Missense_Mutation_p.D364N	NM_023073	NP_075561	E9PH94	E9PH94_HUMAN	hypothetical protein LOC65250	2331										ovary(4)|breast(2)|skin(1)	7	all_lung(31;0.000616)		COAD - Colon adenocarcinoma(61;0.14)|Epithelial(62;0.177)|Colorectal(62;0.202)			ACTGAAGAGTCCTGTTGAGGT	0.388		NaN											0	0	0	0.00361	0	55	96									
PPAP2A	8611	broad.mit.edu	37	5	54737704	54737704	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr5:54737704G>A	uc003jqa.2	-	4	940	c.524C>T	c.(523-525)TCC>TTC	p.S175F	PPAP2A_uc003jpz.2_Missense_Mutation_p.S176F|PPAP2A_uc003jqb.2_RNA	NM_003711	NP_003702	O14494	LPP1_HUMAN	phosphatidic acid phosphatase type 2A isoform 1	175	Helical; (Potential).				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|androgen receptor signaling pathway|germ cell migration|negative regulation of cell proliferation|phospholipid dephosphorylation|regulation of lipid metabolic process|sphingolipid metabolic process	integral to plasma membrane|membrane fraction	phosphatidate phosphatase activity|sphingosine-1-phosphate phosphatase activity			ovary(2)	2		Lung NSC(810;4.08e-05)|Prostate(74;0.0181)|Breast(144;0.0544)				GCAGTACATGGAAAACGAAGA	0.403		NaN											0	0	0	0.001984	0	6	93									
CARTPT	9607	broad.mit.edu	37	5	71015207	71015207	+	Silent	SNP	G	G	A			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr5:71015207G>A	uc003kbv.1	+	1	214	c.87G>A	c.(85-87)GAG>GAA	p.E29E		NM_004291	NP_004282	Q16568	CART_HUMAN	cocaine- and amphetamine-regulated transcript	29					activation of MAPKK activity|adult feeding behavior|cellular glucose homeostasis|cellular response to starvation|circadian regulation of gene expression|negative regulation of appetite|negative regulation of bone resorption|negative regulation of osteoclast differentiation|neuropeptide signaling pathway|positive regulation of blood pressure|positive regulation of epinephrine secretion|positive regulation of transmission of nerve impulse|synaptic transmission	extracellular space				ovary(1)	1		Lung NSC(167;0.00153)|Ovarian(174;0.0175)|Prostate(74;0.11)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;8.4e-56)	Amphetamine(DB00182)	GTGCCCAGGAGGACGCCGAGC	0.662		NaN											0	0	0	0.001984	0	7	127									
BTF3	689	broad.mit.edu	37	5	72798768	72798768	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr5:72798768G>A	uc003kcr.1	+	4	586	c.343G>A	c.(343-345)GTG>ATG	p.V115M	BTF3_uc003kcq.1_Missense_Mutation_p.V71M|BTF3_uc003kcs.1_RNA|BTF3_uc003kct.1_RNA	NM_001037637	NP_001032726	P20290	BTF3_HUMAN	basic transcription factor 3 isoform A	115	NAC-A/B.				regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleus	protein binding				0		Lung NSC(167;0.00405)|Ovarian(174;0.0175)		OV - Ovarian serous cystadenocarcinoma(47;2.73e-54)		CCAAGGAACAGTGATCCACTT	0.363		NaN											0	0	0	0.00361	0	63	98									
HOMER1	9456	broad.mit.edu	37	5	78672000	78672000	+	Silent	SNP	T	T	C			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr5:78672000T>C	uc003kfy.2	-	9	2000	c.897A>G	c.(895-897)AAA>AAG	p.K299K	HOMER1_uc010jab.2_3'UTR|HOMER1_uc010jac.2_Silent_p.K169K|HOMER1_uc010jad.2_Silent_p.K125K	NM_004272	NP_004263	Q86YM7	HOME1_HUMAN	homer 1	299	Potential.				activation of phospholipase C activity by metabotropic glutamate receptor signaling pathway|synaptic transmission	cell junction|integral to plasma membrane|postsynaptic density|postsynaptic membrane					0		Lung NSC(167;0.00131)|all_lung(232;0.00151)|Ovarian(174;0.0261)|Prostate(461;0.191)		OV - Ovarian serous cystadenocarcinoma(54;1.87e-44)|Epithelial(54;7.07e-41)|all cancers(79;5.5e-36)		CCTCCAGGTCTTTGTTCCGAA	0.358		NaN											0	0	0	0.013114	0	44	58									
RASGRF2	5924	broad.mit.edu	37	5	80409473	80409473	+	Missense_Mutation	SNP	G	G	T			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr5:80409473G>T	uc003kha.1	+	15	2204	c.2204G>T	c.(2203-2205)AGA>ATA	p.R735I	RASGRF2_uc011ctn.1_RNA	NM_006909	NP_008840	O14827	RGRF2_HUMAN	Ras protein-specific guanine	735	N-terminal Ras-GEF.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|synaptic transmission	cytosol|endoplasmic reticulum membrane|plasma membrane	protein binding|Rho guanyl-nucleotide exchange factor activity			breast(5)|ovary(3)|large_intestine(2)|central_nervous_system(1)|skin(1)	12		Lung NSC(167;0.00498)|all_lung(232;0.00531)|Ovarian(174;0.0357)		OV - Ovarian serous cystadenocarcinoma(54;4.22e-42)|Epithelial(54;4.04e-35)|all cancers(79;2.52e-29)		GCTGTGTCCAGAACATCTTCC	0.522		NaN											1	0	1.47197e-15	0.007835	1.6439e-15	41	67									
SRFBP1	153443	broad.mit.edu	37	5	121330336	121330336	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr5:121330336G>A	uc003kst.1	+	4	313	c.241G>A	c.(241-243)GAT>AAT	p.D81N		NM_152546	NP_689759	Q8NEF9	SRFB1_HUMAN	serum response factor binding protein 1	81					regulation of transcription, DNA-dependent|transcription, DNA-dependent	perinuclear region of cytoplasm					0		all_cancers(142;0.0124)|Prostate(80;0.0322)	KIRC - Kidney renal clear cell carcinoma(527;0.206)	OV - Ovarian serous cystadenocarcinoma(64;0.000227)|Epithelial(69;0.000365)|all cancers(49;0.00517)		TCTTGGTGATGATATCAACTT	0.254		NaN											0	0	0	0.00245	0	14	12									
FBN2	2201	broad.mit.edu	37	5	127800489	127800489	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr5:127800489C>G	uc003kuu.2	-	6	1193	c.754G>C	c.(754-756)GAG>CAG	p.E252Q	FBN2_uc003kuv.2_Missense_Mutation_p.E219Q|FBN2_uc003kuw.3_Missense_Mutation_p.E252Q|FBN2_uc003kux.1_Missense_Mutation_p.E252Q	NM_001999	NP_001990	P35556	FBN2_HUMAN	fibrillin 2 precursor	252	TB 1.				bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			ovary(8)|large_intestine(4)|pancreas(1)|kidney(1)|skin(1)	15		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		GGACACATCTCACAGGGATGG	0.607		NaN											0	0	0	0.012213	0	34	121									
DDX46	9879	broad.mit.edu	37	5	134102654	134102654	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr5:134102654C>G	uc003kzw.2	+	3	422	c.254C>G	c.(253-255)TCT>TGT	p.S85C	DDX46_uc003kzv.1_Intron	NM_014829	NP_055644	Q7L014	DDX46_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 46	85	Arg-rich.				mRNA processing|RNA splicing	Cajal body|nuclear speck	ATP binding|ATP-dependent helicase activity|RNA binding			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			CGAAGAAGATCTCGAAGTAGA	0.473		NaN											0	0	0	0.006214	0	10	64									
PCDHA3	56145	broad.mit.edu	37	5	140180995	140180995	+	Missense_Mutation	SNP	C	C	A	rs138112183		TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr5:140180995C>A	uc003lhf.2	+	1	213	c.213C>A	c.(211-213)CAC>CAA	p.H71Q	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA2_uc011czy.1_Intron|PCDHA3_uc011czz.1_Missense_Mutation_p.H71Q	NM_018906	NP_061729	Q9Y5H8	PCDA3_HUMAN	protocadherin alpha 3 isoform 1 precursor	71	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(6)|skin(2)	8			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCAAAAGACACGGGGACCTTC	0.627		NaN											1	0	7.92265e-33	0.00361	9.1869e-33	58	346									
PCDHA12	56137	broad.mit.edu	37	5	140256931	140256931	+	Missense_Mutation	SNP	G	G	T			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr5:140256931G>T	uc003lic.2	+	1	2001	c.1874G>T	c.(1873-1875)GGG>GTG	p.G625V	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc003lia.2_Intron|PCDHA12_uc011daf.1_Missense_Mutation_p.G625V	NM_018903	NP_061726	Q9UN75	PCDAC_HUMAN	protocadherin alpha 12 isoform 1 precursor	625	Cadherin 6.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TTCCACGTGGGGCTGTACACT	0.677		NaN											1	0	6.4308e-24	0.00361	7.27134e-24	53	81									
PCDHB11	56125	broad.mit.edu	37	5	140579906	140579906	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr5:140579906G>C	uc003liy.2	+	1	559	c.559G>C	c.(559-561)GAC>CAC	p.D187H	PCDHB11_uc011daj.1_Intron	NM_018931	NP_061754	Q9Y5F2	PCDBB_HUMAN	protocadherin beta 11 precursor	187	Extracellular (Potential).|Cadherin 2.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			skin(3)|ovary(2)|upper_aerodigestive_tract(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			AGTCATTCCAGACAATAGGAA	0.448		NaN											0	0	0	0.001855	0	13	96									
C5orf54	63920	broad.mit.edu	37	5	159822193	159822193	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr5:159822193C>T	uc003lye.1	-	2	769	c.305G>A	c.(304-306)TGT>TAT	p.C102Y	C5orf54_uc003lyf.1_Missense_Mutation_p.C102Y	NM_022090	NP_071373	Q8IZ13	CE054_HUMAN	transposon-derived Buster3 transposase-like	102										pancreas(1)	1						ctccttggcacataaatacgc	0		NaN											0	0	0	0.00361	0	55	52									
TXNDC5	81567	broad.mit.edu	37	6	7904949	7904949	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr6:7904949G>A	uc003mxv.2	-	2	303	c.271C>T	c.(271-273)CAC>TAC	p.H91Y	TXNDC5_uc003mxw.2_Missense_Mutation_p.H48Y|TXNDC5_uc010jnz.2_5'UTR|TXNDC5_uc010joa.1_5'UTR	NM_030810	NP_110437	Q8NBS9	TXND5_HUMAN	thioredoxin domain containing 5 isoform 1	91	Thioredoxin 1.				anti-apoptosis|cell redox homeostasis|cellular membrane organization|glycerol ether metabolic process|post-Golgi vesicle-mediated transport	endoplasmic reticulum lumen|lysosomal lumen	electron carrier activity|isomerase activity|protein disulfide oxidoreductase activity				0	Ovarian(93;0.0398)					CGCTGGCAGTGTCCACACCTG	0.547		NaN											0	0	0	0.00361	0	55	46									
DCDC2	51473	broad.mit.edu	37	6	24205258	24205258	+	Missense_Mutation	SNP	T	T	A	rs150003705		TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr6:24205258T>A	uc003ndx.2	-	8	1297	c.995A>T	c.(994-996)GAT>GTT	p.D332V	DCDC2_uc003ndy.2_Missense_Mutation_p.D332V|DCDC2_uc003ndw.2_Missense_Mutation_p.D83V	NM_016356	NP_057440	Q9UHG0	DCDC2_HUMAN	doublecortin domain containing 2	332					cellular defense response|intracellular signal transduction|neuron migration					ovary(1)	1		Ovarian(999;0.101)				AACCTGAGTATCTTCATCTTC	0.403		NaN											0	0	0	0.00632	0	25	387									
SLC17A3	10786	broad.mit.edu	37	6	25845738	25845738	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr6:25845738C>T	uc003nfi.3	-	11	1245	c.1135G>A	c.(1135-1137)GAG>AAG	p.E379K	SLC17A3_uc003nfk.3_Missense_Mutation_p.E457K	NM_006632	NP_006623	O00476	NPT4_HUMAN	solute carrier family 17 (sodium phosphate),	379					glucose-6-phosphate transport|urate metabolic process	apical plasma membrane|brush border membrane|endoplasmic reticulum membrane|integral to plasma membrane|perinuclear region of cytoplasm	drug transmembrane transporter activity|efflux transmembrane transporter activity|organic anion transmembrane transporter activity|sodium:phosphate symporter activity|toxin transporter activity|urate transmembrane transporter activity|voltage-gated anion channel activity				0						CACCCAAACTCAGGGTCCTGG	0.413		NaN											0	0	0	0.00361	0	73	44									
SLC17A2	10246	broad.mit.edu	37	6	25921506	25921506	+	Silent	SNP	A	A	T			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr6:25921506A>T	uc011dkb.1	-	3	458	c.375T>A	c.(373-375)GGT>GGA	p.G125G	SLC17A2_uc011dkc.1_Silent_p.G125G|SLC17A2_uc003nfl.2_Silent_p.G125G			O00624	NPT3_HUMAN	SubName: Full=Solute carrier family 17 (Sodium phosphate), member 2, isoform CRA_b; SubName: Full=Putative uncharacterized protein SLC17A2;	125					phosphate metabolic process	integral to plasma membrane|membrane fraction	sodium:phosphate symporter activity			ovary(1)	1						AGATCAGCAAACCAGCACCAA	0.468		NaN											0	0	0	0.008871	0	19	129									
ZNF184	7738	broad.mit.edu	37	6	27425078	27425078	+	Silent	SNP	T	T	A			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr6:27425078T>A	uc003njj.2	-	3	997	c.186A>T	c.(184-186)ACA>ACT	p.T62T	ZNF184_uc010jqv.2_Silent_p.T62T|ZNF184_uc003nji.2_Silent_p.T62T	NM_007149	NP_009080	Q99676	ZN184_HUMAN	zinc finger protein 184	62	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						AGACCAGGTGTGTATAATTTT	0.448		NaN											0	0	0	0.001368	0	12	134									
OR2B2	81697	broad.mit.edu	37	6	27879892	27879892	+	Missense_Mutation	SNP	A	A	T			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr6:27879892A>T	uc011dkw.1	-	1	206	c.206T>A	c.(205-207)CTG>CAG	p.L69Q		NM_033057	NP_149046	Q9GZK3	OR2B2_HUMAN	olfactory receptor, family 2, subfamily B,	69	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						GCAAAGGTCCAGGAGTGAGAG	0.413		NaN											0	0	0	0.005524	0	37	80									
ZNF193	7746	broad.mit.edu	37	6	28200426	28200426	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr6:28200426G>C	uc003nkq.1	+	4	770	c.655G>C	c.(655-657)GAG>CAG	p.E219Q	ZNF193_uc003nkr.1_Missense_Mutation_p.E219Q|ZNF193_uc010jqz.1_Missense_Mutation_p.E270Q	NM_006299	NP_006290	O15535	ZN193_HUMAN	zinc finger protein 193	219					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0						AATGTTTAATGAGCAGACCTG	0.458		NaN											0	0	0	0.001368	0	13	85									
PPP1R11	6992	broad.mit.edu	37	6	30035194	30035194	+	Nonsense_Mutation	SNP	G	G	T			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr6:30035194G>T	uc003npb.2	+	1	263	c.7G>T	c.(7-9)GAG>TAG	p.E3*	PPP1R11_uc010jrw.2_RNA|PPP1R11_uc003npc.2_RNA	NM_021959	NP_068778	O60927	PP1RB_HUMAN	protein phosphatase 1, regulatory (inhibitor)	3						soluble fraction	protein binding|protein phosphatase inhibitor activity			ovary(1)|lung(1)|skin(1)	3						AGCCATGGCCGAGGCAGGGGC	0.607		NaN											1	0	1.45844e-13	0.002836	1.62214e-13	31	171									
KIAA1949	170954	broad.mit.edu	37	6	30652748	30652748	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr6:30652748C>G	uc003nra.2	-	2	1279	c.1048G>C	c.(1048-1050)GAG>CAG	p.E350Q	KIAA1949_uc003nrb.3_Missense_Mutation_p.E350Q	NM_001134870	NP_001128342	Q6NYC8	PHTNS_HUMAN	phostensin	350						cytoplasm|cytoskeleton	actin binding				0						GTTTGAGCCTCTATGTCCCTG	0.577		NaN											0	0	0	0.003163	0	16	295									
CCHCR1	54535	broad.mit.edu	37	6	31110756	31110756	+	Silent	SNP	G	G	C			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr6:31110756G>C	uc003nsr.3	-	17	2331	c.2208C>G	c.(2206-2208)ACC>ACG	p.T736T	CCHCR1_uc011dne.1_Silent_p.T722T|CCHCR1_uc003nsq.3_Silent_p.T789T|CCHCR1_uc003nsp.3_Silent_p.T825T	NM_019052	NP_061925	Q8TD31	CCHCR_HUMAN	coiled-coil alpha-helical rod protein 1 isoform	736					cell differentiation|multicellular organismal development	cytoplasm|nucleus	protein binding			skin(1)	1						TGGACTCCCTGGTGGGCACTG	0.532		NaN											0	0	0	0.00361	0	61	779									
C6orf27	80737	broad.mit.edu	37	6	31733741	31733741	+	Silent	SNP	C	C	G			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr6:31733741C>G	uc011dog.1	-	16	2656	c.2418G>C	c.(2416-2418)GTG>GTC	p.V806V		NM_025258	NP_079534	Q9Y334	G7C_HUMAN	G7c protein precursor	806						extracellular region				ovary(3)	3						CCCCTGCAGTCACAGTCACCA	0.637		NaN											0	0	0	0.00278	0	24	440									
DAXX	1616	broad.mit.edu	37	6	33289243	33289243	+	Silent	SNP	C	C	T			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr6:33289243C>T	uc003oec.2	-	3	513	c.309G>A	c.(307-309)GCG>GCA	p.A103A	DAXX_uc011drd.1_Silent_p.A28A|DAXX_uc011dre.1_Silent_p.A115A|DAXX_uc003oed.2_Silent_p.A103A|DAXX_uc010juw.2_Silent_p.A28A	NM_001350	NP_001341	Q9UER7	DAXX_HUMAN	death-domain associated protein isoform a	103	Necessary for interaction with USP7.				activation of JUN kinase activity|androgen receptor signaling pathway|apoptosis|induction of apoptosis via death domain receptors|interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|regulation of protein ubiquitination|transcription, DNA-dependent	chromosome, centromeric region|cytosol|nucleolus|PML body	androgen receptor binding|heat shock protein binding|p53 binding|protein homodimerization activity|protein N-terminus binding|receptor signaling protein activity|transcription factor binding|ubiquitin protein ligase binding	p.A103fs*40(1)		pancreas(18)|ovary(2)|skin(2)|prostate(1)	23						TGCAGAACTCCGCCGAGGCCA	0.562		NaN	Mis|F|N		Pancreatic neuroendocrine tumors								0	0	0	0.008291	0	10	271									
LHFPL5	222662	broad.mit.edu	37	6	35773642	35773642	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr6:35773642C>G	uc003olg.1	+	1	572	c.195C>G	c.(193-195)TTC>TTG	p.F65L		NM_182548	NP_872354	Q8TAF8	TMHS_HUMAN	lipoma HMGIC fusion partner-like 5	65	Helical; (Potential).					integral to membrane				skin(1)	1						TCGGCCTTTTCTCCTACTGCG	0.587		NaN											0	0	0	0.00361	0	311	165									
KIF6	221458	broad.mit.edu	37	6	39545887	39545887	+	Missense_Mutation	SNP	C	C	A			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr6:39545887C>A	uc003oot.2	-	10	1221	c.1126G>T	c.(1126-1128)GCC>TCC	p.A376S	KIF6_uc010jxa.1_Missense_Mutation_p.A167S|KIF6_uc011dua.1_Missense_Mutation_p.A376S|KIF6_uc010jxb.1_Missense_Mutation_p.A376S	NM_145027	NP_659464	Q6ZMV9	KIF6_HUMAN	kinesin family member 6	376	Potential.				microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity|protein binding			breast(2)|central_nervous_system(1)	3						GTGACCATGGCCAGTTCATCC	0.428		NaN											1	0	2.4624e-09	0.008871	2.67865e-09	19	201									
TREM2	54209	broad.mit.edu	37	6	41126740	41126740	+	Missense_Mutation	SNP	A	A	T			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr6:41126740A>T	uc003opy.2	-	4	649	c.547T>A	c.(547-549)TTT>ATT	p.F183I	TREM2_uc003opz.2_Missense_Mutation_p.L226H|TREM2_uc010jxl.1_Intron	NM_018965	NP_061838	Q9NZC2	TREM2_HUMAN	triggering receptor expressed on myeloid cells 2	183	Helical; (Potential).				axon guidance|humoral immune response	extracellular region|integral to membrane|plasma membrane	receptor activity			ovary(1)	1	Ovarian(28;0.0418)|Colorectal(47;0.196)					TTGATGAGAAAGATGCAGGCC	0.567		NaN											0	0	0	0.008291	0	11	104									
PRICKLE4	29964	broad.mit.edu	37	6	41754506	41754506	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr6:41754506C>T	uc011duf.1	+	8	1042	c.794C>T	c.(793-795)ACT>ATT	p.T265I	PRICKLE4_uc003ord.2_RNA|TOMM6_uc003org.2_RNA|TOMM6_uc011dug.1_5'Flank	NM_013397	NP_037529	Q2TBC4	PRIC4_HUMAN	over-expressed breast tumor protein	225						nucleus	zinc ion binding				0	Ovarian(28;0.0355)|Colorectal(47;0.121)		Epithelial(12;8.38e-05)|STAD - Stomach adenocarcinoma(11;0.000204)|Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)			ACAGGGGAGACTGGACTCGAC	0.612		NaN											0	0	0	0.001855	0	14	193									
HTR1B	3351	broad.mit.edu	37	6	78172393	78172393	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr6:78172393G>A	uc003pil.1	-	1	728	c.728C>T	c.(727-729)ACG>ATG	p.T243M		NM_000863	NP_000854	P28222	5HT1B_HUMAN	5-hydroxytryptamine (serotonin) receptor 1B	243	Cytoplasmic (By similarity).				G-protein signaling, coupled to cyclic nucleotide second messenger|negative regulation of cAMP biosynthetic process|synaptic transmission	integral to plasma membrane	protein binding|serotonin receptor activity				0		all_cancers(76;0.0867)|Acute lymphoblastic leukemia(125;0.00119)|all_hematologic(105;0.0332)		BRCA - Breast invasive adenocarcinoma(397;0.205)	Almotriptan(DB00918)|Dexfenfluramine(DB01191)|Dihydroergotamine(DB00320)|Eletriptan(DB00216)|Ergotamine(DB00696)|Frovatriptan(DB00998)|Naratriptan(DB00952)|Pindolol(DB00960)|Propranolol(DB00571)|Rizatriptan(DB00953)|Sumatriptan(DB00669)|Venlafaxine(DB00285)|Zolmitriptan(DB00315)	CCTGTTGGGCGTCTGTTTCAA	0.612		NaN											0	0	0	0.00361	0	69	37									
DSE	29940	broad.mit.edu	37	6	116757645	116757645	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr6:116757645C>T	uc003pws.2	+	6	2208	c.2014C>T	c.(2014-2016)CAG>TAG	p.Q672*	DSE_uc011ebg.1_Nonsense_Mutation_p.Q691*|DSE_uc003pwt.2_Nonsense_Mutation_p.Q672*|DSE_uc003pwu.2_Nonsense_Mutation_p.Q339*	NM_001080976	NP_001074445	Q9UL01	DSE_HUMAN	dermatan sulfate epimerase precursor	672					dermatan sulfate biosynthetic process	endoplasmic reticulum|Golgi apparatus|integral to membrane	chondroitin-glucuronate 5-epimerase activity			ovary(1)	1		all_cancers(87;0.00019)|all_epithelial(87;0.000416)|Ovarian(999;0.133)|Colorectal(196;0.234)		Epithelial(106;0.00915)|OV - Ovarian serous cystadenocarcinoma(136;0.0149)|GBM - Glioblastoma multiforme(226;0.0189)|all cancers(137;0.0262)		TATAGATGTTCAGAGCTTCAC	0.517		NaN											0	0	0	0.00361	0	55	127									
VNN1	8876	broad.mit.edu	37	6	133014264	133014264	+	Missense_Mutation	SNP	A	A	G			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr6:133014264A>G	uc003qdo.2	-	4	745	c.725T>C	c.(724-726)TTG>TCG	p.L242S		NM_004666	NP_004657	O95497	VNN1_HUMAN	vanin 1 precursor	242	CN hydrolase.				acute inflammatory response|anti-apoptosis|cell-cell adhesion|cellular component movement|chronic inflammatory response|innate immune response|pantothenate metabolic process|positive regulation of T cell differentiation in thymus|response to oxidative stress	anchored to membrane|integral to membrane|plasma membrane	GPI anchor binding|pantetheine hydrolase activity			ovary(3)	3	Breast(56;0.135)			OV - Ovarian serous cystadenocarcinoma(155;0.0027)|GBM - Glioblastoma multiforme(226;0.0189)		CAAATGTGGCAAAACATTCAT	0.428		NaN											0	0	0	0.00361	0	50	34									
STX11	8676	broad.mit.edu	37	6	144508445	144508445	+	Silent	SNP	C	C	G	rs145774130	byFrequency	TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr6:144508445C>G	uc003qks.3	+	2	873	c.681C>G	c.(679-681)CTC>CTG	p.L227L		NM_003764	NP_003755	O75558	STX11_HUMAN	syntaxin 11	227	t-SNARE coiled-coil homology.				cellular membrane fusion|intracellular protein transport|vesicle-mediated transport	Golgi apparatus|membrane	SNAP receptor activity			ovary(1)|central_nervous_system(1)	2				OV - Ovarian serous cystadenocarcinoma(155;2.17e-06)|GBM - Glioblastoma multiforme(68;0.0492)		TACACGAGCTCTTCTTGCAGA	0.652		NaN							Familial_Hemophagocytic_Lymphohistiocytosis				0	0	0	0.006999	0	41	25									
IYD	389434	broad.mit.edu	37	6	150713540	150713540	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr6:150713540G>C	uc003qnu.1	+	3	570	c.430G>C	c.(430-432)GAC>CAC	p.D144H	IYD_uc003qnv.1_Missense_Mutation_p.D144H|IYD_uc003qnw.1_RNA|IYD_uc003qnx.1_Missense_Mutation_p.D144H|IYD_uc010kik.1_Missense_Mutation_p.D62H	NM_203395	NP_981932	Q6PHW0	IYD1_HUMAN	iodotyrosine dehalogenase 1 isoform 2	144	Extracellular (Potential).				cellular nitrogen compound metabolic process|hormone biosynthetic process	integral to membrane|plasma membrane				ovary(2)	2		Ovarian(120;0.028)	BRCA - Breast invasive adenocarcinoma(37;0.215)	OV - Ovarian serous cystadenocarcinoma(155;4.16e-12)		GAAGGACCCAGACGTGAAGCA	0.493		NaN											0	0	0	0.012319	0	23	196									
TIAM2	26230	broad.mit.edu	37	6	155451184	155451184	+	Missense_Mutation	SNP	G	G	T			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr6:155451184G>T	uc003qqb.2	+	6	2100	c.827G>T	c.(826-828)AGT>ATT	p.S276I	TIAM2_uc003qqe.2_Missense_Mutation_p.S276I	NM_012454	NP_036586	Q8IVF5	TIAM2_HUMAN	T-cell lymphoma invasion and metastasis 2	276					apoptosis|cellular lipid metabolic process|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|filopodium|growth cone|lamellipodium	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			ovary(3)|breast(1)	4		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;8.1e-13)|BRCA - Breast invasive adenocarcinoma(81;0.0053)		CCTGACCCCAGTCTCCATGCC	0.602		NaN											1	0	9.4991e-31	0.00361	1.09451e-30	68	31									
CARD11	84433	broad.mit.edu	37	7	2978460	2978460	+	Silent	SNP	C	C	T			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr7:2978460C>T	uc003smv.2	-	7	1274	c.870G>A	c.(868-870)GGG>GGA	p.G290G		NM_032415	NP_115791	Q9BXL7	CAR11_HUMAN	caspase recruitment domain family, member 11	290	Potential.				positive regulation of cytokine production|positive regulation of NF-kappaB transcription factor activity|regulation of apoptosis|T cell costimulation|T cell receptor signaling pathway	cytosol|membrane raft|plasma membrane	CARD domain binding|guanylate kinase activity			haematopoietic_and_lymphoid_tissue(43)|ovary(2)|kidney(2)|skin(2)|central_nervous_system(1)	50		Ovarian(82;0.0115)		OV - Ovarian serous cystadenocarcinoma(56;8.44e-14)		GGCTGCGCTTCCCGGCCTGGG	0.632		NaN	Mis		DLBCL								0	0	0	0.00308	0	7	65									
GLI3	2737	broad.mit.edu	37	7	42005113	42005113	+	Silent	SNP	C	C	A			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr7:42005113C>A	uc011kbh.1	-	15	3649	c.3558G>T	c.(3556-3558)CCG>CCT	p.P1186P	GLI3_uc011kbg.1_Silent_p.P1127P	NM_000168	NP_000159	P10071	GLI3_HUMAN	GLI-Kruppel family member GLI3	1186					negative regulation of alpha-beta T cell differentiation|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of smoothened signaling pathway|negative regulation of transcription from RNA polymerase II promoter|negative thymic T cell selection|positive regulation of alpha-beta T cell differentiation|positive regulation of transcription from RNA polymerase II promoter|thymocyte apoptosis	cilium|cytosol|nucleolus	beta-catenin binding|histone acetyltransferase binding|histone deacetylase binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(11)|ovary(3)|large_intestine(2)|central_nervous_system(1)|kidney(1)|pancreas(1)	19						CGCGAGTCTGCGGCACAGCGG	0.652		NaN							Greig_Cephalopolysyndactyly|Pallister-Hall_syndrome				1	0	3.61922e-38	0.00361	4.20571e-38	92	179									
GLI3	2737	broad.mit.edu	37	7	42005561	42005561	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr7:42005561G>A	uc011kbh.1	-	15	3201	c.3110C>T	c.(3109-3111)ACG>ATG	p.T1037M	GLI3_uc011kbg.1_Missense_Mutation_p.T978M	NM_000168	NP_000159	P10071	GLI3_HUMAN	GLI-Kruppel family member GLI3	1037					negative regulation of alpha-beta T cell differentiation|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of smoothened signaling pathway|negative regulation of transcription from RNA polymerase II promoter|negative thymic T cell selection|positive regulation of alpha-beta T cell differentiation|positive regulation of transcription from RNA polymerase II promoter|thymocyte apoptosis	cilium|cytosol|nucleolus	beta-catenin binding|histone acetyltransferase binding|histone deacetylase binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(11)|ovary(3)|large_intestine(2)|central_nervous_system(1)|kidney(1)|pancreas(1)	19						CTCCGCGGACGTGGCCATCGC	0.697		NaN							Greig_Cephalopolysyndactyly|Pallister-Hall_syndrome				0	0	0	0.007413	0	17	60									
OGDH	4967	broad.mit.edu	37	7	44736090	44736090	+	Missense_Mutation	SNP	G	G	T			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr7:44736090G>T	uc003tln.2	+	14	1943	c.1834G>T	c.(1834-1836)GAT>TAT	p.D612Y	OGDH_uc011kbx.1_Missense_Mutation_p.D608Y|OGDH_uc011kby.1_Missense_Mutation_p.D462Y|OGDH_uc003tlp.2_Missense_Mutation_p.D623Y|OGDH_uc011kbz.1_Missense_Mutation_p.D407Y|OGDH_uc003tlo.1_Missense_Mutation_p.D445Y	NM_002541	NP_002532	Q02218	ODO1_HUMAN	oxoglutarate dehydrogenase isoform 1 precursor	612					glycolysis|lysine catabolic process|tricarboxylic acid cycle	mitochondrial matrix|mitochondrial membrane	oxoglutarate dehydrogenase (succinyl-transferring) activity|thiamine pyrophosphate binding			upper_aerodigestive_tract(1)|ovary(1)	2					NADH(DB00157)	TCTGACGGAGGATATTCTGAC	0.527		NaN											1	0	1.96292e-10	0.010504	2.1525e-10	21	102									
OGDH	4967	broad.mit.edu	37	7	44737336	44737336	+	Silent	SNP	G	G	C			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr7:44737336G>C	uc003tln.2	+	17	2422	c.2313G>C	c.(2311-2313)CGG>CGC	p.R771R	OGDH_uc011kbx.1_Silent_p.R767R|OGDH_uc011kby.1_Silent_p.R621R|OGDH_uc003tlp.2_Silent_p.R782R|OGDH_uc011kbz.1_Silent_p.R566R	NM_002541	NP_002532	Q02218	ODO1_HUMAN	oxoglutarate dehydrogenase isoform 1 precursor	771					glycolysis|lysine catabolic process|tricarboxylic acid cycle	mitochondrial matrix|mitochondrial membrane	oxoglutarate dehydrogenase (succinyl-transferring) activity|thiamine pyrophosphate binding			upper_aerodigestive_tract(1)|ovary(1)	2					NADH(DB00157)	AGTGGGTGCGGCAGAATGGCA	0.602		NaN											0	0	0	0.004482	0	7	148									
CACNA2D1	781	broad.mit.edu	37	7	81746455	81746455	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr7:81746455C>T	uc003uhr.1	-	6	687	c.431G>A	c.(430-432)AGG>AAG	p.R144K		NM_000722	NP_000713	P54289	CA2D1_HUMAN	calcium channel, voltage-dependent, alpha	144	Extracellular (Potential).					voltage-gated calcium channel complex	metal ion binding			ovary(5)|pancreas(1)	6					Felodipine(DB01023)|Gabapentin(DB00996)|Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Nifedipine(DB01115)	AGGTTTTATCCTCTGGCTGCC	0.358		NaN											0	0	0	0.006214	0	10	46									
PCLO	27445	broad.mit.edu	37	7	82595105	82595105	+	Missense_Mutation	SNP	T	T	A			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr7:82595105T>A	uc003uhx.2	-	4	4288	c.3999A>T	c.(3997-3999)GAA>GAT	p.E1333D	PCLO_uc003uhv.2_Missense_Mutation_p.E1333D	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						CTTTCCCAGGTTCCACCTGAT	0.373		NaN											0	0	0	0.004289	0	32	81									
GRM3	2913	broad.mit.edu	37	7	86416022	86416022	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr7:86416022C>T	uc003uid.2	+	3	2013	c.914C>T	c.(913-915)GCG>GTG	p.A305V	GRM3_uc010lef.2_Missense_Mutation_p.A303V|GRM3_uc010leg.2_Missense_Mutation_p.A177V|GRM3_uc010leh.2_Intron	NM_000840	NP_000831	Q14832	GRM3_HUMAN	glutamate receptor, metabotropic 3 precursor	305	Extracellular (Potential).				synaptic transmission	integral to plasma membrane				lung(4)|ovary(3)|central_nervous_system(2)|skin(2)|haematopoietic_and_lymphoid_tissue(1)|prostate(1)	13	Esophageal squamous(14;0.0058)|all_lung(186;0.132)|Lung NSC(181;0.142)				Acamprosate(DB00659)|Nicotine(DB00184)	GGCTGGGGCGCGCAGGAGAGC	0.677		NaN											0	0	0	0.003163	0	15	83									
GAL3ST4	79690	broad.mit.edu	37	7	99758066	99758066	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr7:99758066C>T	uc003utt.2	-	3	1963	c.946G>A	c.(946-948)GAT>AAT	p.D316N	C7orf43_uc011kjj.1_5'Flank|C7orf43_uc003utr.2_5'Flank|C7orf43_uc003uts.2_5'Flank|GAL3ST4_uc003utu.2_Missense_Mutation_p.D316N|GAL3ST4_uc010lgq.2_Missense_Mutation_p.D254N	NM_024637	NP_078913	Q96RP7	G3ST4_HUMAN	galactose-3-O-sulfotransferase 4	316	Lumenal (Potential).				cell-cell signaling|oligosaccharide metabolic process|proteoglycan biosynthetic process|sulfur compound metabolic process	Golgi cisterna membrane|integral to membrane|membrane fraction	3'-phosphoadenosine 5'-phosphosulfate binding|galactosylceramide sulfotransferase activity|proteoglycan sulfotransferase activity			ovary(3)	3	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					CACAGGGCATCTGCCAGCAGA	0.557		NaN											0	0	0	0.00361	0	47	147									
TRIP6	7205	broad.mit.edu	37	7	100469281	100469281	+	Silent	SNP	C	C	T			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr7:100469281C>T	uc003uww.2	+	7	1286	c.1116C>T	c.(1114-1116)CTC>CTT	p.L372L		NM_003302	NP_003293	Q15654	TRIP6_HUMAN	thyroid receptor-interacting protein 6	372	LIM zinc-binding 2.				focal adhesion assembly|positive regulation of cell migration|regulation of transcription, DNA-dependent|release of cytoplasmic sequestered NF-kappaB|transcription, DNA-dependent	cytoplasm|cytoskeleton|focal adhesion|nucleus	identical protein binding|interleukin-1 receptor binding|kinase binding|thyroid hormone receptor binding|zinc ion binding			central_nervous_system(2)	2	Lung NSC(181;0.041)|all_lung(186;0.0581)					ACCGCGGCCTCGACGGCATCC	0.622		NaN											0	0	0	0.00623	0	35	49									
MUC17	140453	broad.mit.edu	37	7	100682960	100682960	+	Missense_Mutation	SNP	A	A	T			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr7:100682960A>T	uc003uxp.1	+	3	8316	c.8263A>T	c.(8263-8265)AGT>TGT	p.S2755C	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	2755	Extracellular (Potential).|Ser-rich.|59 X approximate tandem repeats.|44.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					TCCATTAACAAGTATACTTGT	0.493		NaN											0	0	0	0.012319	0	22	650									
MUC17	140453	broad.mit.edu	37	7	100693838	100693838	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr7:100693838G>A	uc003uxp.1	+	7	12849	c.12796G>A	c.(12796-12798)GAC>AAC	p.D4266N	MUC17_uc010lho.1_Intron	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	4266	Extracellular (Potential).|SEA.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					GACAGTATTGGACAATGCCAC	0.463		NaN											0	0	0	0.004656	0	27	80									
RELN	5649	broad.mit.edu	37	7	103197585	103197585	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr7:103197585G>C	uc003vca.2	-	38	5796	c.5636C>G	c.(5635-5637)TCT>TGT	p.S1879C	RELN_uc010liz.2_Missense_Mutation_p.S1879C	NM_005045	NP_005036	P78509	RELN_HUMAN	reelin isoform a	1879					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			ovary(8)|upper_aerodigestive_tract(5)|large_intestine(2)|central_nervous_system(2)|skin(1)|pancreas(1)	19				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		TAACAGAATAGAGTGAGATCT	0.378		NaN											0	0	0	0.001168	0	6	53									
ZC3HAV1	56829	broad.mit.edu	37	7	138764694	138764694	+	Silent	SNP	T	T	C			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr7:138764694T>C	uc003vun.2	-	4	1381	c.993A>G	c.(991-993)TTA>TTG	p.L331L	ZC3HAV1_uc003vuo.2_5'Flank|ZC3HAV1_uc003vup.2_Silent_p.L331L	NM_020119	NP_064504	Q7Z2W4	ZCCHV_HUMAN	zinc finger antiviral protein isoform 1	331					response to virus	cytoplasm|nucleus	NAD+ ADP-ribosyltransferase activity|RNA binding|zinc ion binding			ovary(1)	1						TGCCGTTCTCTAAAAACCTCT	0.552		NaN											0	0	0	0.00361	0	63	70									
TAS2R39	259285	broad.mit.edu	37	7	142880649	142880649	+	Silent	SNP	C	C	A			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr7:142880649C>A	uc011ksw.1	+	1	138	c.138C>A	c.(136-138)CTC>CTA	p.L46L		NM_176881	NP_795362	P59534	T2R39_HUMAN	taste receptor, type 2, member 39	46	Helical; Name=1; (Potential).				sensory perception of taste	integral to membrane	G-protein coupled receptor activity			skin(1)	1	Melanoma(164;0.059)					CTGAATACCTCATTGGTATCA	0.413		NaN											1	0	0.00307968	0.00308	0.00315493	7	53									
MFHAS1	9258	broad.mit.edu	37	8	8748771	8748771	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr8:8748771C>G	uc003wsj.1	-	1	2361	c.1798G>C	c.(1798-1800)GAC>CAC	p.D600H		NM_004225	NP_004216	Q9Y4C4	MFHA1_HUMAN	malignant fibrous histiocytoma amplified	600	Roc.										0		Hepatocellular(245;0.217)		COAD - Colon adenocarcinoma(149;0.124)		AGGTTCTTGTCCGAAACGCCA	0.642		NaN											0	0	0	0.001984	0	7	104									
DLC1	10395	broad.mit.edu	37	8	12957634	12957634	+	Missense_Mutation	SNP	T	T	A			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr8:12957634T>A	uc003wwm.2	-	9	2656	c.2212A>T	c.(2212-2214)ACG>TCG	p.T738S	DLC1_uc003wwk.1_Missense_Mutation_p.T301S|DLC1_uc003wwl.1_Missense_Mutation_p.T335S|DLC1_uc011kxx.1_Missense_Mutation_p.T227S	NM_182643	NP_872584	Q96QB1	RHG07_HUMAN	deleted in liver cancer 1 isoform 1	738					actin cytoskeleton organization|activation of caspase activity|focal adhesion assembly|forebrain development|heart morphogenesis|hindbrain morphogenesis|induction of apoptosis|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of Rho protein signal transduction|negative regulation of stress fiber assembly|neural tube closure|positive regulation of protein dephosphorylation|regulation of cell shape|small GTPase mediated signal transduction	caveola|cytosol|focal adhesion|nucleus	Rho GTPase activator activity|SH2 domain binding			ovary(3)|pancreas(2)|lung(1)|kidney(1)	7						CTGGTCTGCGTGGAGTTGGAA	0.617		NaN											0	0	0	0.003954	0	25	81									
DLC1	10395	broad.mit.edu	37	8	12958064	12958064	+	Silent	SNP	G	G	A			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr8:12958064G>A	uc003wwm.2	-	9	2226	c.1782C>T	c.(1780-1782)GTC>GTT	p.V594V	DLC1_uc003wwk.1_Silent_p.V157V|DLC1_uc003wwl.1_Silent_p.V191V|DLC1_uc011kxx.1_Silent_p.V83V	NM_182643	NP_872584	Q96QB1	RHG07_HUMAN	deleted in liver cancer 1 isoform 1	594					actin cytoskeleton organization|activation of caspase activity|focal adhesion assembly|forebrain development|heart morphogenesis|hindbrain morphogenesis|induction of apoptosis|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of Rho protein signal transduction|negative regulation of stress fiber assembly|neural tube closure|positive regulation of protein dephosphorylation|regulation of cell shape|small GTPase mediated signal transduction	caveola|cytosol|focal adhesion|nucleus	Rho GTPase activator activity|SH2 domain binding			ovary(3)|pancreas(2)|lung(1)|kidney(1)	7						TGAGGCTGCGGACGGAAGACA	0.697		NaN											0	0	0	0.00499	0	17	118									
MTUS1	57509	broad.mit.edu	37	8	17611869	17611869	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr8:17611869G>C	uc003wxv.2	-	2	1922	c.1448C>G	c.(1447-1449)ACA>AGA	p.T483R	MTUS1_uc010lsy.2_RNA|MTUS1_uc003wxw.2_Missense_Mutation_p.T483R|MTUS1_uc010lsz.2_Missense_Mutation_p.T483R	NM_001001924	NP_001001924	Q9ULD2	MTUS1_HUMAN	mitochondrial tumor suppressor 1 isoform 1	483						Golgi apparatus|microtubule|microtubule organizing center|mitochondrion|nucleus|plasma membrane|spindle				ovary(1)|skin(1)	2				Colorectal(111;0.0778)		CGTTTTGATTGTTGATTTTCC	0.378		NaN											0	0	0	0.00361	0	75	143									
UNC5D	137970	broad.mit.edu	37	8	35579728	35579728	+	Missense_Mutation	SNP	G	G	T			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr8:35579728G>T	uc003xjr.1	+	9	1446	c.1118G>T	c.(1117-1119)AGC>ATC	p.S373I	UNC5D_uc003xjs.1_Missense_Mutation_p.S368I|UNC5D_uc003xju.1_5'Flank|UNC5D_uc003xjt.1_Missense_Mutation_p.G131V	NM_080872	NP_543148	Q6UXZ4	UNC5D_HUMAN	unc-5 homolog D precursor	373	Extracellular (Potential).				apoptosis|axon guidance	integral to membrane	receptor activity			upper_aerodigestive_tract(2)|ovary(2)|pancreas(1)|skin(1)	6				READ - Rectum adenocarcinoma(1;1.31e-05)|Colorectal(1;0.000723)		TGTCTTTCAGGCATTGAGAAT	0.493		NaN											1	0	1.06961e-07	0.00308	1.12754e-07	8	182									
RAB11FIP1	80223	broad.mit.edu	37	8	37730513	37730513	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr8:37730513C>T	uc003xkm.1	-	4	1851	c.1807G>A	c.(1807-1809)GCA>ACA	p.A603T	RAB11FIP1_uc010lvz.1_Intron|RAB11FIP1_uc003xkn.1_Intron|RAB11FIP1_uc003xkl.1_5'UTR|RAB11FIP1_uc003xko.1_5'UTR|RAB11FIP1_uc003xkp.1_Intron	NM_001002814	NP_001002814	Q6WKZ4	RFIP1_HUMAN	RAB11 family interacting protein 1 isoform 3	603	Ser-rich.				protein transport	centrosome|phagocytic vesicle membrane|recycling endosome	protein binding			ovary(1)|central_nervous_system(1)|skin(1)	3		Lung NSC(58;0.118)|all_lung(54;0.195)	LUSC - Lung squamous cell carcinoma(8;3.62e-11)			ATGGGAGCTGCTATGGGAGAT	0.547		NaN											0	0	0	0.002836	0	34	111									
RGS22	26166	broad.mit.edu	37	8	101075735	101075735	+	Missense_Mutation	SNP	A	A	G			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr8:101075735A>G	uc003yjb.1	-	8	1456	c.1261T>C	c.(1261-1263)TTT>CTT	p.F421L	RGS22_uc003yja.1_Missense_Mutation_p.F240L|RGS22_uc003yjc.1_Missense_Mutation_p.F409L|RGS22_uc011lgz.1_RNA|RGS22_uc010mbo.1_RNA	NM_015668	NP_056483	Q8NE09	RGS22_HUMAN	regulator of G-protein signaling 22	421					negative regulation of signal transduction	cytoplasm|plasma membrane	GTPase activator activity|signal transducer activity			ovary(3)|skin(2)|breast(1)|central_nervous_system(1)	7			Epithelial(11;6.71e-08)|all cancers(13;4.19e-06)|OV - Ovarian serous cystadenocarcinoma(57;0.000469)|STAD - Stomach adenocarcinoma(118;0.169)			CCTTTTATAAATTTCTTAAAT	0.388		NaN											0	0	0	0.006122	0	15	68									
PKHD1L1	93035	broad.mit.edu	37	8	110489537	110489537	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr8:110489537C>T	uc003yne.2	+	53	9105	c.9001C>T	c.(9001-9003)CAA>TAA	p.Q3001*		NM_177531	NP_803875	Q86WI1	PKHL1_HUMAN	fibrocystin L precursor	3001	Extracellular (Potential).				immune response	cytosol|extracellular space|integral to membrane	receptor activity			ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			TATTAATTTCCAAGCTTACTG	0.418		NaN								HNSCC(38;0.096)			0	0	0	0.012213	0	34	45									
GSDMD	79792	broad.mit.edu	37	8	144643221	144643221	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr8:144643221C>T	uc010mfe.2	+	8	1332	c.629C>T	c.(628-630)TCA>TTA	p.S210L	uc003yye.2_5'Flank|GSDMD_uc003yyf.2_Missense_Mutation_p.S258L|GSDMD_uc003yyi.2_3'UTR|GSDMD_uc003yyg.2_Missense_Mutation_p.S210L|GSDMD_uc003yyh.2_Missense_Mutation_p.S141L	NM_024736	NP_079012	P57764	GSDMD_HUMAN	gasdermin D	210											0						ACCATCCCCTCAGGCAGCACC	0.667		NaN											0	0	0	0.001168	0	6	50									
TTC39B	158219	broad.mit.edu	37	9	15187022	15187022	+	Silent	SNP	C	C	T			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr9:15187022C>T	uc003zlr.1	-	15	1330	c.1209G>A	c.(1207-1209)GTG>GTA	p.V403V	TTC39B_uc003zlq.1_Silent_p.V372V|TTC39B_uc011lmp.1_Silent_p.V304V|TTC39B_uc010mie.1_Silent_p.V401V|TTC39B_uc011lmq.1_Silent_p.V390V|TTC39B_uc011lmr.1_Silent_p.V334V|TTC39B_uc010mif.1_Silent_p.V403V|TTC39B_uc003zlp.1_5'UTR	NM_152574	NP_689787	Q5VTQ0	TT39B_HUMAN	tetratricopeptide repeat domain 39B	403							binding			ovary(1)	1						CTTTCAAGAACACATAAGTTG	0.383		NaN											0	0	0	0.007835	0	39	39									
DMRTA1	63951	broad.mit.edu	37	9	22451128	22451128	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr9:22451128C>T	uc003zpp.1	+	2	958	c.733C>T	c.(733-735)CAG>TAG	p.Q245*		NM_022160	NP_071443	Q5VZB9	DMRTA_HUMAN	DMRT-like family A1	245					cell differentiation|sex differentiation	nucleus	DNA binding|metal ion binding|sequence-specific DNA binding transcription factor activity			large_intestine(1)|skin(1)	2		all_cancers(5;4.09e-243)|Acute lymphoblastic leukemia(3;8.25e-150)|all_hematologic(3;4.25e-147)|Esophageal squamous(3;2.32e-09)|Renal(3;1.71e-07)|Breast(3;2.07e-06)|Hepatocellular(5;0.00563)		GBM - Glioblastoma multiforme(1;5.12e-278)|Lung(24;8.2e-52)|LUSC - Lung squamous cell carcinoma(38;1.46e-37)|OV - Ovarian serous cystadenocarcinoma(39;0.0517)		CAAATCCCATCAGCTTTACCT	0.398		NaN											0	0	0	0.003163	0	15	17									
STOML2	30968	broad.mit.edu	37	9	35102793	35102793	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr9:35102793G>C	uc003zwi.2	-	2	136	c.73C>G	c.(73-75)CCG>GCG	p.P25A	STOML2_uc003zwh.2_5'UTR|STOML2_uc003zwj.2_5'UTR|STOML2_uc011lou.1_Missense_Mutation_p.P25A|STOML2_uc003zwk.2_5'UTR	NM_013442	NP_038470	Q9UJZ1	STML2_HUMAN	stomatin (EPB72)-like 2	25						cytoskeleton	receptor binding				0			LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00778)			GCGCGGCGCGGAGCGCGGCCA	0.647		NaN											0	0	0	0.003271	0	34	77									
EPB41L4B	54566	broad.mit.edu	37	9	111970252	111970252	+	Silent	SNP	A	A	G			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr9:111970252A>G	uc004bdz.1	-	18	2125	c.1830T>C	c.(1828-1830)TGT>TGC	p.C610C		NM_019114	NP_061987	Q9H329	E41LB_HUMAN	erythrocyte membrane protein band 4.1 like 4B	610						cytoplasm|cytoskeleton|extrinsic to membrane	cytoskeletal protein binding|structural constituent of cytoskeleton			ovary(1)|central_nervous_system(1)|skin(1)	3						TCAGAATGTTACACTTCACAT	0.428		NaN											0	0	0	0.008871	0	19	119									
HSDL2	84263	broad.mit.edu	37	9	115216316	115216316	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr9:115216316G>C	uc004bga.1	+	9	982	c.889G>C	c.(889-891)GAG>CAG	p.E297Q	HSDL2_uc011lwv.1_Missense_Mutation_p.E176Q|HSDL2_uc004bgb.1_Missense_Mutation_p.E131Q|HSDL2_uc004bgc.1_Missense_Mutation_p.E224Q|HSDL2_uc011lww.1_Missense_Mutation_p.E92Q	NM_032303	NP_115679	Q6YN16	HSDL2_HUMAN	hydroxysteroid dehydrogenase like 2	297						peroxisome	oxidoreductase activity|sterol binding				0						ATTCAAAGAAGAGAAACTGCA	0.403		NaN											0	0	0	0.006214	0	9	49									
CRB2	286204	broad.mit.edu	37	9	126128573	126128573	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr9:126128573G>A	uc004bnx.1	+	4	774	c.682G>A	c.(682-684)GCA>ACA	p.A228T	CRB2_uc004bnw.1_Missense_Mutation_p.A228T	NM_173689	NP_775960	Q5IJ48	CRUM2_HUMAN	crumbs homolog 2 precursor	228	Extracellular (Potential).|EGF-like 5.					extracellular region|integral to membrane|plasma membrane	calcium ion binding			ovary(1)	1						GCTGGAGTGCGCATCGGCGCC	0.741		NaN											0	0	0	0.001168	0	5	3									
SPTAN1	6709	broad.mit.edu	37	9	131356499	131356499	+	Silent	SNP	G	G	A			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr9:131356499G>A	uc004bvl.3	+	24	3374	c.3261G>A	c.(3259-3261)TTG>TTA	p.L1087L	SPTAN1_uc011mbg.1_Silent_p.L1067L|SPTAN1_uc011mbh.1_Silent_p.L1099L|SPTAN1_uc004bvm.3_Silent_p.L1087L|SPTAN1_uc004bvn.3_Silent_p.L1067L	NM_003127	NP_003118	Q13813	SPTA2_HUMAN	spectrin, alpha, non-erythrocytic 1	1087	Spectrin 11.				actin filament capping|axon guidance|cellular component disassembly involved in apoptosis	cytosol|intracellular membrane-bounded organelle|membrane fraction|microtubule cytoskeleton|spectrin	actin binding|calcium ion binding|calmodulin binding|structural constituent of cytoskeleton			breast(5)|ovary(4)|pancreas(1)	10						AAGGCATGTTGGAGAAGAGTT	0.468		NaN											0	0	0	0.010771	0	43	36									
SPTAN1	6709	broad.mit.edu	37	9	131356542	131356542	+	Nonsense_Mutation	SNP	G	G	T			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr9:131356542G>T	uc004bvl.3	+	24	3417	c.3304G>T	c.(3304-3306)GAA>TAA	p.E1102*	SPTAN1_uc011mbg.1_Nonsense_Mutation_p.E1082*|SPTAN1_uc011mbh.1_Nonsense_Mutation_p.E1114*|SPTAN1_uc004bvm.3_Nonsense_Mutation_p.E1102*|SPTAN1_uc004bvn.3_Nonsense_Mutation_p.E1082*	NM_003127	NP_003118	Q13813	SPTA2_HUMAN	spectrin, alpha, non-erythrocytic 1	1102	Spectrin 12.				actin filament capping|axon guidance|cellular component disassembly involved in apoptosis	cytosol|intracellular membrane-bounded organelle|membrane fraction|microtubule cytoskeleton|spectrin	actin binding|calcium ion binding|calmodulin binding|structural constituent of cytoskeleton			breast(5)|ovary(4)|pancreas(1)	10						TGAAGCGAATGAACTACAGCA	0.468		NaN											1	0	1.19451e-25	0.00361	1.3648e-25	48	38									
SPTAN1	6709	broad.mit.edu	37	9	131362362	131362362	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr9:131362362G>A	uc004bvl.3	+	27	3660	c.3547G>A	c.(3547-3549)GAA>AAA	p.E1183K	SPTAN1_uc011mbh.1_Missense_Mutation_p.E1195K|SPTAN1_uc004bvm.3_Missense_Mutation_p.E1183K|SPTAN1_uc004bvn.3_Missense_Mutation_p.E1163K	NM_003127	NP_003118	Q13813	SPTA2_HUMAN	spectrin, alpha, non-erythrocytic 1	1183					actin filament capping|axon guidance|cellular component disassembly involved in apoptosis	cytosol|intracellular membrane-bounded organelle|membrane fraction|microtubule cytoskeleton|spectrin	actin binding|calcium ion binding|calmodulin binding|structural constituent of cytoskeleton			breast(5)|ovary(4)|pancreas(1)	10						TGAATAGGATGAAACTGATTC	0.438		NaN											0	0	0	0.003755	0	34	20									
SPTAN1	6709	broad.mit.edu	37	9	131367332	131367332	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr9:131367332G>C	uc004bvl.3	+	30	3852	c.3739G>C	c.(3739-3741)GAA>CAA	p.E1247Q	SPTAN1_uc011mbh.1_Missense_Mutation_p.E1259Q|SPTAN1_uc004bvm.3_Missense_Mutation_p.E1247Q|SPTAN1_uc004bvn.3_Missense_Mutation_p.E1227Q	NM_003127	NP_003118	Q13813	SPTA2_HUMAN	spectrin, alpha, non-erythrocytic 1	1247	Spectrin 14.				actin filament capping|axon guidance|cellular component disassembly involved in apoptosis	cytosol|intracellular membrane-bounded organelle|membrane fraction|microtubule cytoskeleton|spectrin	actin binding|calcium ion binding|calmodulin binding|structural constituent of cytoskeleton			breast(5)|ovary(4)|pancreas(1)	10						TGAAACCAAAGAATGGATTGA	0.413		NaN											0	0	0	0.005524	0	37	25									
SPTAN1	6709	broad.mit.edu	37	9	131378100	131378100	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr9:131378100G>A	uc004bvl.3	+	40	5436	c.5323G>A	c.(5323-5325)GAC>AAC	p.D1775N	SPTAN1_uc004bvm.3_Missense_Mutation_p.D1780N|SPTAN1_uc004bvn.3_Missense_Mutation_p.D1755N	NM_003127	NP_003118	Q13813	SPTA2_HUMAN	spectrin, alpha, non-erythrocytic 1	1775	Spectrin 19.				actin filament capping|axon guidance|cellular component disassembly involved in apoptosis	cytosol|intracellular membrane-bounded organelle|membrane fraction|microtubule cytoskeleton|spectrin	actin binding|calcium ion binding|calmodulin binding|structural constituent of cytoskeleton			breast(5)|ovary(4)|pancreas(1)	10						GGACATGGATGACGAGGAGTC	0.567		NaN											0	0	0	0.010771	0	44	25									
SPTAN1	6709	broad.mit.edu	37	9	131394948	131394948	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr9:131394948G>A	uc004bvl.3	+	54	7209	c.7096G>A	c.(7096-7098)GAA>AAA	p.E2366K	SPTAN1_uc004bvm.3_Missense_Mutation_p.E2371K|SPTAN1_uc004bvn.3_Missense_Mutation_p.E2346K|SPTAN1_uc004bvo.3_Missense_Mutation_p.E133K|SPTAN1_uc004bvp.3_Missense_Mutation_p.E109K	NM_003127	NP_003118	Q13813	SPTA2_HUMAN	spectrin, alpha, non-erythrocytic 1	2366	EF-hand 2.				actin filament capping|axon guidance|cellular component disassembly involved in apoptosis	cytosol|intracellular membrane-bounded organelle|membrane fraction|microtubule cytoskeleton|spectrin	actin binding|calcium ion binding|calmodulin binding|structural constituent of cytoskeleton			breast(5)|ovary(4)|pancreas(1)	10						GGAGGAAGGGGAACCTGACCC	0.567		NaN											0	0	0	0.00361	0	58	35									
WDR34	89891	broad.mit.edu	37	9	131397156	131397156	+	Silent	SNP	G	G	A			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr9:131397156G>A	uc004bvq.1	-	7	1150	c.1026C>T	c.(1024-1026)TTC>TTT	p.F342F	WDR34_uc004bvs.1_Silent_p.F333F|WDR34_uc004bvr.1_Silent_p.F314F	NM_052844	NP_443076	Q96EX3	WDR34_HUMAN	WD repeat domain 34	342						cytoplasm				central_nervous_system(2)|skin(1)	3						CAAAGCTGGAGAAGGCCACTG	0.647		NaN									OREG0019522	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.005443	0	26	14									
KCNT1	57582	broad.mit.edu	37	9	138650354	138650354	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr9:138650354G>A	uc011mdq.1	+	10	928	c.854G>A	c.(853-855)GGG>GAG	p.G285E	KCNT1_uc011mdr.1_Missense_Mutation_p.G112E|KCNT1_uc010nbf.2_Missense_Mutation_p.G237E|KCNT1_uc004cgo.1_Missense_Mutation_p.G34E	NM_020822	NP_065873	Q5JUK3	KCNT1_HUMAN	potassium channel, subfamily T, member 1	285						membrane	binding|calcium-activated potassium channel activity			large_intestine(2)|ovary(1)|pancreas(1)	4		Myeloproliferative disorder(178;0.0821)		OV - Ovarian serous cystadenocarcinoma(145;2.11e-07)|Epithelial(140;1.57e-06)|all cancers(34;9.22e-05)		GTTTTCACGGGGTGAGTGCCG	0.612		NaN											0	0	0	0.004289	0	33	31									
SEC16A	9919	broad.mit.edu	37	9	139348776	139348776	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr9:139348776G>A	uc004chx.2	-	21	6170	c.5861C>T	c.(5860-5862)CCG>CTG	p.P1954L	SEC16A_uc004chs.2_5'Flank|SEC16A_uc004cht.2_5'UTR|SEC16A_uc004chu.2_Missense_Mutation_p.P139L|SEC16A_uc004chv.3_Missense_Mutation_p.P1344L|SEC16A_uc004chw.2_Missense_Mutation_p.P1954L|SEC16A_uc010nbn.2_Missense_Mutation_p.P1954L	NM_014866	NP_055681	O15027	SC16A_HUMAN	SEC16 homolog A	1776	Pro-rich.				protein transport|vesicle-mediated transport	endoplasmic reticulum membrane|Golgi membrane					0		Myeloproliferative disorder(178;0.0511)		Epithelial(140;2.9e-06)|OV - Ovarian serous cystadenocarcinoma(145;5.88e-06)		GAGCGTCTGCGGAGCTGCATG	0.602		NaN											0	0	0	0.004672	0	2	5									
XG	7499	broad.mit.edu	37	X	2670373	2670373	+	Silent	SNP	C	C	A			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chrX:2670373C>A	uc011mhg.1	+	1	281	c.58C>A	c.(58-60)CGA>AGA	p.R20R	XG_uc010ndb.2_RNA|XG_uc004cqp.2_Silent_p.R20R	NM_175569	NP_780778	P55808	XG_HUMAN	XG glycoprotein isoform 1 precursor	20						integral to membrane|plasma membrane				ovary(1)	1		all_cancers(21;9e-05)|all_epithelial(21;6.22e-06)|all_lung(23;0.000597)|Lung NSC(23;0.00901)|Lung SC(21;0.186)				AATGCACGCCCGAGGTAAGAG	0.483		NaN											1	0	3.17917e-66	0.00361	3.73416e-66	114	190									
RPGR	6103	broad.mit.edu	37	X	38156597	38156597	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chrX:38156597C>T	uc004ded.1	-	11	1522	c.1354G>A	c.(1354-1356)GAG>AAG	p.E452K	RPGR_uc004deb.2_Missense_Mutation_p.E452K|RPGR_uc004dea.2_RNA|RPGR_uc004dec.2_RNA|RPGR_uc004dee.1_Missense_Mutation_p.E137K	NM_001034853	NP_001030025	Q92834	RPGR_HUMAN	retinitis pigmentosa GTPase regulator isoform C	452					intracellular protein transport|response to stimulus|visual perception	Golgi apparatus|photoreceptor outer segment	guanyl-nucleotide exchange factor activity|protein binding			ovary(1)	1						AGGTTTCTCTCAGAACATCGT	0.453		NaN											0	0	0	0.010504	0	21	36									
SLC35A2	7355	broad.mit.edu	37	X	48762196	48762196	+	Silent	SNP	G	G	A	rs146079657	byFrequency	TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chrX:48762196G>A	uc004dlo.1	-	4	994	c.990C>T	c.(988-990)CTC>CTT	p.L330L	SLC35A2_uc011mml.1_Silent_p.L343L|SLC35A2_uc004dlp.1_Silent_p.L330L|SLC35A2_uc011mmm.1_Silent_p.L358L|SLC35A2_uc011mmn.1_Silent_p.L269L|SLC35A2_uc004dlr.1_Missense_Mutation_p.S184L|SLC35A2_uc004dlq.2_Intron	NM_005660	NP_005651	P78381	S35A2_HUMAN	solute carrier family 35, member A2 isoform a	330	Helical; (Potential).				galactose metabolic process	Golgi membrane|integral to membrane|nucleus	sugar:hydrogen symporter activity|UDP-galactose transmembrane transporter activity			breast(1)	1						CACCAATGACGAGTCCAGCGC	0.607		NaN											0	0	0	0.005443	0	24	5									
KCND1	3750	broad.mit.edu	37	X	48826378	48826378	+	Missense_Mutation	SNP	C	C	A			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chrX:48826378C>A	uc004dlx.1	-	1	1874	c.301G>T	c.(301-303)GGG>TGG	p.G101W	KCND1_uc004dlw.1_5'Flank	NM_004979	NP_004970	Q9NSA2	KCND1_HUMAN	potassium voltage-gated channel, Shal-related	101	Cytoplasmic (Potential).					voltage-gated potassium channel complex	metal ion binding|voltage-gated potassium channel activity			ovary(2)|lung(1)	3						TGCAGCCGCCCCGTTCGGTAG	0.582		NaN											1	0	0.000274275	0.004482	0.000282038	8	32									
CCDC120	90060	broad.mit.edu	37	X	48921477	48921477	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chrX:48921477G>A	uc010nik.2	+	5	776	c.269G>A	c.(268-270)CGC>CAC	p.R90H	CCDC120_uc011mmq.1_Missense_Mutation_p.R78H|CCDC120_uc004dmf.2_Missense_Mutation_p.R90H|CCDC120_uc010nil.2_Missense_Mutation_p.R90H|CCDC120_uc011mmr.1_Missense_Mutation_p.R90H|CCDC120_uc011mms.1_Missense_Mutation_p.R78H	NM_033626	NP_296375	Q96HB5	CC120_HUMAN	coiled-coil domain containing 120 isoform 3	90							protein binding			pancreas(1)	1						CCCACAGCCCGCGCCTACCCT	0.682		NaN											0	0	0	0.009096	0	4	22									
HEPH	9843	broad.mit.edu	37	X	65427138	65427138	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chrX:65427138G>A	uc011moz.1	+	14	2462	c.2402G>A	c.(2401-2403)CGG>CAG	p.R801Q	HEPH_uc004dwn.2_Missense_Mutation_p.R801Q|HEPH_uc004dwo.2_Missense_Mutation_p.R531Q|HEPH_uc010nkr.2_Missense_Mutation_p.R609Q|HEPH_uc011mpa.1_Missense_Mutation_p.R801Q|HEPH_uc010nks.2_Missense_Mutation_p.R90Q	NM_138737	NP_620074	Q9BQS7	HEPH_HUMAN	hephaestin isoform a	798	Extracellular (Potential).|Plastocyanin-like 5.				cellular iron ion homeostasis|copper ion transport|transmembrane transport	integral to membrane|plasma membrane	copper ion binding|oxidoreductase activity			lung(5)|ovary(4)	9						AGGATCCCTCGGCCAAGGACT	0.478		NaN											0	0	0	0.001855	0	14	3									
PDZD4	57595	broad.mit.edu	37	X	153072223	153072223	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chrX:153072223C>G	uc004fiz.1	-	4	710	c.460G>C	c.(460-462)GAG>CAG	p.E154Q	PDZD4_uc004fiy.1_Missense_Mutation_p.E79Q|PDZD4_uc004fix.2_Missense_Mutation_p.E58Q|PDZD4_uc004fja.1_Missense_Mutation_p.E160Q|PDZD4_uc011mze.1_Missense_Mutation_p.E45Q	NM_032512	NP_115901	Q76G19	PDZD4_HUMAN	PDZ domain containing 4	154	PDZ.					cell cortex				breast(1)	1	all_lung(58;3.39e-06)|all_hematologic(71;4.25e-06)|Lung NSC(58;4.7e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					CCCAGGTCCTCCTCGTCGTCC	0.627		NaN											0	0	0	0.00361	0	67	16									
SPEN	23013	broad.mit.edu	37	1	16260122	16260130	+	In_Frame_Del	DEL	AGCGATCCA	AGCGATCCA	-			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr1:16260122_16260130delAGCGATCCA	uc001axk.1	+	11	7591_7599	c.7387_7395delAGCGATCCA	c.(7387-7395)AGCGATCCAdel	p.SDP2463del	SPEN_uc010obp.1_In_Frame_Del_p.SDP2422del	NM_015001	NP_055816	Q96T58	MINT_HUMAN	spen homolog, transcriptional regulator	2463_2465	RID.|Pro-rich.				interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|Notch signaling pathway	nucleus	nucleotide binding|protein binding|RNA binding			ovary(6)|breast(3)|lung(2)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	15		Colorectal(325;0.000258)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0185)|Colorectal(212;5.96e-07)|COAD - Colon adenocarcinoma(227;3.11e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000115)|Kidney(64;0.000212)|KIRC - Kidney renal clear cell carcinoma(64;0.003)|STAD - Stomach adenocarcinoma(313;0.013)|READ - Rectum adenocarcinoma(331;0.0681)		GACCCCACCCAGCGATCCAAGCATCCCCA	0.603		NaN											NaN	NaN	NaN	NaN	NaN	12	117	---	---							
FAU	2197	broad.mit.edu	37	11	64888248	64888250	+	In_Frame_Del	DEL	TCT	TCT	-	rs1065065		TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr11:64888248_64888250delTCT	uc001ocx.2	-	5	412_414	c.305_307delAGA	c.(304-309)AAGACA>ACA	p.K102del	FAU_uc001ocy.1_3'UTR|MRPL49_uc001ocz.1_5'Flank|MRPL49_uc001oda.1_5'Flank	NM_001997	NP_001988	P35544	UBIM_HUMAN	ubiquitin-like protein fubi and ribosomal	Error:Variant_position_missing_in_P35544_after_alignment											0						GCCCGACCTGTCTTCTTCTTCTT	0.542		NaN											NaN	NaN	NaN	NaN	NaN	7	282	---	---							
CLIP1	6249	broad.mit.edu	37	12	122812690	122812691	+	Frame_Shift_Ins	INS	-	-	T			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr12:122812690_122812691insT	uc001ucg.1	-	16	3158_3159	c.3052_3053insA	c.(3052-3054)AGCfs	p.S1018fs	CLIP1_uc001uch.1_Frame_Shift_Ins_p.S1007fs|CLIP1_uc001uci.1_Frame_Shift_Ins_p.S972fs|CLIP1_uc001ucj.1_Frame_Shift_Ins_p.S593fs	NM_002956	NP_002947	P30622	CLIP1_HUMAN	restin isoform a	1018	Potential.				mitotic prometaphase|positive regulation of microtubule polymerization	centrosome|cytosol|endosome|intermediate filament|kinetochore	nucleic acid binding|protein homodimerization activity|zinc ion binding			ovary(2)|breast(1)	3	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.81e-05)|Epithelial(86;6.85e-05)|BRCA - Breast invasive adenocarcinoma(302;0.226)		CTGGTTGTGGCTTGTTTCCATT	0.505		NaN											NaN	NaN	NaN	NaN	NaN	20	389	---	---							
OR4N2	390429	broad.mit.edu	37	14	20296055	20296056	+	Frame_Shift_Ins	INS	-	-	T	rs149523724	by1000genomes	TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr14:20296055_20296056insT	uc010tkv.1	+	1	448_449	c.448_449insT	c.(448-450)CTTfs	p.L150fs		NM_001004723	NP_001004723	Q8NGD1	OR4N2_HUMAN	olfactory receptor, family 4, subfamily N,	150	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|central_nervous_system(1)|skin(1)	4	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		GGCTCTGTGGCTTGGGGGTTTT	0.53		NaN											NaN	NaN	NaN	NaN	NaN	57	347	---	---							
SLC10A1	6554	broad.mit.edu	37	14	70252841	70252841	+	Frame_Shift_Del	DEL	C	C	-			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr14:70252841delC	uc001xlr.2	-	2	674	c.540delG	c.(538-540)CGGfs	p.R180fs		NM_003049	NP_003040	Q14973	NTCP_HUMAN	solute carrier family 10, member 1	180					bile acid metabolic process|organic anion transport	integral to plasma membrane	bile acid:sodium symporter activity			ovary(1)	1				all cancers(60;0.00228)|BRCA - Breast invasive adenocarcinoma(234;0.0137)|OV - Ovarian serous cystadenocarcinoma(108;0.0226)		TGTATTGTGGCCGTTTGGATT	0.438		NaN											NaN	NaN	NaN	NaN	NaN	36	116	---	---							
RPL23	9349	broad.mit.edu	37	17	37008873	37008892	+	Frame_Shift_Del	DEL	TGGTTTGCCTTTCTTGACTG	TGGTTTGCCTTTCTTGACTG	-			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr17:37008873_37008892delTGGTTTGCCTTTCTTGACTG	uc002hqx.1	-	3	281_300	c.191_210delCAGTCAAGAAAGGCAAACCA	c.(190-210)ACAGTCAAGAAAGGCAAACCAfs	p.T64fs	RPL23_uc002hqw.1_Frame_Shift_Del_p.T5fs|RPL23_uc002hqy.1_Frame_Shift_Del_p.T64fs	NM_000978	NP_000969	P62829	RL23_HUMAN	ribosomal protein L23	64_70					endocrine pancreas development|ribosomal protein import into nucleus|translational elongation|translational termination|viral transcription	cytosol|ribosome	protein binding|structural constituent of ribosome				0						TTCTGAGCTCTGGTTTGCCTTTCTTGACTGTGGCCATCAC	0.482		NaN											NaN	NaN	NaN	NaN	NaN	11	133	---	---							
NBR1	4077	broad.mit.edu	37	17	41352619	41352619	+	Frame_Shift_Del	DEL	T	T	-			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr17:41352619delT	uc010czd.2	+	17	2602	c.2462delT	c.(2461-2463)CTGfs	p.L821fs	NBR1_uc010diz.2_Frame_Shift_Del_p.L821fs|NBR1_uc010whu.1_Frame_Shift_Del_p.L821fs|NBR1_uc010whv.1_Frame_Shift_Del_p.L821fs|NBR1_uc010whw.1_Frame_Shift_Del_p.L800fs	NM_031862	NP_114068	Q14596	NBR1_HUMAN	neighbor of BRCA1 gene 1	821					macroautophagy|protein oligomerization	autophagic vacuole|cytoplasmic vesicle|cytosol|late endosome|lysosome|sarcomere	ubiquitin binding|zinc ion binding			skin(1)	1		Breast(137;0.00086)		BRCA - Breast invasive adenocarcinoma(366;0.0934)		CCACCGTCACTGCCCAGGTAC	0.517		NaN											NaN	NaN	NaN	NaN	NaN	41	94	---	---							
GNA13	10672	broad.mit.edu	37	17	63010685	63010696	+	In_Frame_Del	DEL	ATTGTTTCAAAA	ATTGTTTCAAAA	-			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr17:63010685_63010696delATTGTTTCAAAA	uc002jfc.2	-	4	1022_1033	c.813_824delTTTTGAAACAAT	c.(811-825)ATTTTTGAAACAATC>ATC	p.271_275IFETI>I	GNA13_uc010wqh.1_In_Frame_Del_p.176_180IFETI>I	NM_006572	NP_006563	Q14344	GNA13_HUMAN	guanine nucleotide binding protein (G protein),	271_275					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase D activity|cellular component movement|platelet activation|Rho protein signal transduction	brush border membrane|heterotrimeric G-protein complex|melanosome	D5 dopamine receptor binding|G-protein beta/gamma-subunit complex binding|GTP binding|GTPase activity|signal transducer activity|type 1 angiotensin receptor binding				0						GTTATTGACGATTGTTTCAAAAATGTTCAGAG	0.396		NaN											NaN	NaN	NaN	NaN	NaN	12	205	---	---							
ZNF574	64763	broad.mit.edu	37	19	42584313	42584319	+	Frame_Shift_Del	DEL	GGGGAGC	GGGGAGC	-			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr19:42584313_42584319delGGGGAGC	uc002osm.3	+	2	1724_1730	c.1555_1561delGGGGAGC	c.(1555-1563)GGGGAGCGGfs	p.G519fs	ZNF574_uc002osk.3_Frame_Shift_Del_p.G609fs	NM_022752	NP_073589	Q6ZN55	ZN574_HUMAN	zinc finger protein 574	519_521					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Prostate(69;0.059)				CACACACACAGGGGAGCGGCCCTTCCC	0.609		NaN											NaN	NaN	NaN	NaN	NaN	15	786	---	---							
SLMO2	51012	broad.mit.edu	37	20	57613514	57613526	+	Splice_Site	DEL	CACTTACAGACTT	CACTTACAGACTT	-			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr20:57613514_57613526delCACTTACAGACTT	uc002yam.2	-	2	317	c.201_splice	c.e2+1	p.S67_splice	SLMO2_uc010zzv.1_Splice_Site_p.S67_splice	NM_016045	NP_057129	Q9Y3B1	SLMO2_HUMAN	slowmo homolog 2											skin(1)	1	all_lung(29;0.00711)		Colorectal(105;0.109)			AATAAAGACACACTTACAGACTTCACAATGGAA	0.437		NaN											NaN	NaN	NaN	NaN	NaN	20	200	---	---							
AP1B1	162	broad.mit.edu	37	22	29745198	29745206	+	Splice_Site	DEL	CTGGCTCAC	CTGGCTCAC	-			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr22:29745198_29745206delCTGGCTCAC	uc003afj.2	-	11	1621	c.1437_splice	c.e11+1	p.Q479_splice	AP1B1_uc003afi.2_Splice_Site_p.Q479_splice|AP1B1_uc003afk.2_Splice_Site_p.Q479_splice|AP1B1_uc003afl.2_Splice_Site_p.Q479_splice|AP1B1_uc011ako.1_Splice_Site_p.Q32_splice	NM_001127	NP_001118	Q10567	AP1B1_HUMAN	adaptor-related protein complex 1 beta 1 subunit						endocytosis|intracellular protein transport|post-Golgi vesicle-mediated transport|regulation of defense response to virus by virus|viral reproduction	clathrin adaptor complex|clathrin coated vesicle membrane|cytosol|Golgi membrane|lysosomal membrane	protein binding|protein transporter activity			ovary(1)|skin(1)	2						GGCCAGCTCGCTGGCTCACCTGTGTGCTC	0.584		NaN											NaN	NaN	NaN	NaN	NaN	12	107	---	---							
MECOM	2122	broad.mit.edu	37	3	168833343	168833348	+	In_Frame_Del	DEL	GGGGCT	GGGGCT	-			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr3:168833343_168833348delGGGGCT	uc003ffi.3	-	7	2017_2022	c.1748_1753delAGCCCC	c.(1747-1755)CAGCCCCTG>CTG	p.QP583del	MECOM_uc010hwk.1_In_Frame_Del_p.QP606del|MECOM_uc003ffj.3_In_Frame_Del_p.QP648del|MECOM_uc011bpi.1_In_Frame_Del_p.QP584del|MECOM_uc003ffn.3_In_Frame_Del_p.QP583del|MECOM_uc003ffk.2_In_Frame_Del_p.QP583del|MECOM_uc003ffl.2_In_Frame_Del_p.QP743del|MECOM_uc011bpj.1_In_Frame_Del_p.QP771del|MECOM_uc011bpk.1_In_Frame_Del_p.QP573del|MECOM_uc010hwn.2_In_Frame_Del_p.QP771del	NM_005241	NP_005232	Q03112	EVI1_HUMAN	MDS1 and EVI1 complex locus isoform b	583_584	CTBP-binding motif 2 (By similarity).				apoptosis|cell differentiation|hemopoietic stem cell proliferation|negative regulation of JNK cascade|negative regulation of programmed cell death|negative regulation of transcription, DNA-dependent|regulation of cell cycle	nuclear speck	DNA binding|protein binding|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(5)|skin(5)|upper_aerodigestive_tract(1)|central_nervous_system(1)|ovary(1)|pancreas(1)	14						CTTAGATCCAGGGGCTGGTCTTGGCT	0.534		NaN											NaN	NaN	NaN	NaN	NaN	15	170	---	---							
SLC22A4	6583	broad.mit.edu	37	5	131676327	131676327	+	Frame_Shift_Del	DEL	T	T	-			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr5:131676327delT	uc003kwq.2	+	9	1679	c.1514delT	c.(1513-1515)CTTfs	p.L505fs	uc003kwr.3_Intron	NM_003059	NP_003050	Q9H015	S22A4_HUMAN	solute carrier family 22 member 4	505	Helical; Name=12; (Potential).				body fluid secretion|sodium ion transport	apical plasma membrane|integral to plasma membrane|mitochondrion	ATP binding|carnitine transporter activity|cation:cation antiporter activity|PDZ domain binding|secondary active organic cation transmembrane transporter activity|symporter activity				0		all_cancers(142;0.0752)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)		L-Carnitine(DB00583)	ATCCTCACCCTTTTTTTCCCT	0.418		NaN											NaN	NaN	NaN	NaN	NaN	8	267	---	---							
PCDHGA7	56108	broad.mit.edu	37	5	140763792	140763792	+	Frame_Shift_Del	DEL	G	G	-			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr5:140763792delG	uc003lka.1	+	1	1326	c.1326delG	c.(1324-1326)GTGfs	p.V442fs	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003ljz.1_Frame_Shift_Del_p.V442fs	NM_018920	NP_061743	Q9Y5G6	PCDG7_HUMAN	protocadherin gamma subfamily A, 7 isoform 1	442	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCATGCAGGTGGCAGACACCA	0.507		NaN											NaN	NaN	NaN	NaN	NaN	13	116	---	---							
MDC1	9656	broad.mit.edu	37	6	30671304	30671305	+	Frame_Shift_Ins	INS	-	-	T			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr6:30671304_30671305insT	uc003nrg.3	-	11	6012_6013	c.5572_5573insA	c.(5572-5574)ACTfs	p.T1858fs	MDC1_uc003nrf.3_Frame_Shift_Ins_p.T489fs	NM_014641	NP_055456	Q14676	MDC1_HUMAN	mediator of DNA-damage checkpoint 1	1858	Required for nuclear localization (NLS2).				cell cycle|double-strand break repair via homologous recombination|intra-S DNA damage checkpoint	focal adhesion|nucleoplasm	FHA domain binding|protein C-terminus binding			breast(2)|ovary(1)|kidney(1)	4						TGGTTTTGGAGTCACGACATCC	0.505		NaN						Other_conserved_DNA_damage_response_genes					NaN	NaN	NaN	NaN	NaN	223	167	---	---							
CDKN1A	1026	broad.mit.edu	37	6	36651884	36651885	+	Frame_Shift_Ins	INS	-	-	G			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08			-	G	-	-		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr6:36651884_36651885insG	uc003omm.3	+	2	128_129	c.6_7insG	c.(4-9)TCAGAAfs	p.S2fs	CDKN1A_uc011dtq.1_Frame_Shift_Ins_p.S36fs|CDKN1A_uc003oml.2_Frame_Shift_Ins_p.S2fs|CDKN1A_uc003omn.2_Frame_Shift_Ins_p.S2fs	NM_000389	NP_000380	P38936	CDN1A_HUMAN	cyclin-dependent kinase inhibitor 1A	2_3					cell cycle arrest|cellular response to extracellular stimulus|cellular response to ionizing radiation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|G2/M transition of mitotic cell cycle|induction of apoptosis by intracellular signals|negative regulation of cell growth|negative regulation of cell proliferation|positive regulation of fibroblast proliferation|positive regulation of reactive oxygen species metabolic process|Ras protein signal transduction|S phase of mitotic cell cycle|stress-induced premature senescence	cyclin-dependent protein kinase holoenzyme complex|cytosol|nucleoplasm|PCNA-p21 complex	cyclin-dependent protein kinase activating kinase activity|cyclin-dependent protein kinase inhibitor activity|metal ion binding			ovary(1)|breast(1)	2						GCGCCATGTCAGAACCGGCTGG	0.629		NaN							Multiple_Endocrine_Neoplasia_type_1				NaN	NaN	NaN	NaN	NaN	18	18	---	---							
GTF2I	2969	broad.mit.edu	37	7	74105441	74105469	+	Splice_Site	DEL	ATTGTAAGCATTGTATTTTTATCTTTTGC	ATTGTAAGCATTGTATTTTTATCTTTTGC	-			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr7:74105441_74105469delATTGTAAGCATTGTATTTTTATCTTTTGC	uc003uau.2	+	3	608	c.238_splice	c.e3+1	p.C80_splice	GTF2I_uc003uat.2_Splice_Site_p.C80_splice|GTF2I_uc003uav.2_Splice_Site_p.C80_splice|GTF2I_uc003uaw.2_Splice_Site_p.C80_splice|GTF2I_uc003uay.2_Splice_Site_p.C80_splice|GTF2I_uc003uax.2_Splice_Site_p.C80_splice	NM_032999	NP_127492	P78347	GTF2I_HUMAN	general transcription factor IIi isoform 1						negative regulation of angiogenesis|signal transduction|transcription initiation from RNA polymerase II promoter	cytoplasm|nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity				0						TTTGTAAAATATTGTAAGCATTGTATTTTTATCTTTTGCATTTCATTAA	0.24		NaN											NaN	NaN	NaN	NaN	NaN	8	98	---	---							
PLXNA4	91584	broad.mit.edu	37	7	131825479	131825493	+	In_Frame_Del	DEL	CAGAGAGGCAGGCGT	CAGAGAGGCAGGCGT	-			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr7:131825479_131825493delCAGAGAGGCAGGCGT	uc003vra.3	-	30	5532_5546	c.5303_5317delACGCCTGCCTCTCTG	c.(5302-5319)GACGCCTGCCTCTCTGTG>GTG	p.DACLS1768del	PLXNA4_uc003vqz.3_In_Frame_Del_p.DACLS53del	NM_020911	NP_065962	Q9HCM2	PLXA4_HUMAN	plexin A4 isoform 1	1768_1772	Cytoplasmic (Potential).					integral to membrane|intracellular|plasma membrane				ovary(1)	1						TGAGCCACCACAGAGAGGCAGGCGTCTGTGATGCT	0.558		NaN											NaN	NaN	NaN	NaN	NaN	15	195	---	---							
FNTA	2339	broad.mit.edu	37	8	42911569	42911570	+	Frame_Shift_Ins	INS	-	-	C			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr8:42911569_42911570insC	uc003xps.2	+	1	128_129	c.80_81insC	c.(79-81)CACfs	p.H27fs	FNTA_uc003xpt.2_5'UTR|FNTA_uc003xpu.2_Frame_Shift_Ins_p.H27fs|FNTA_uc003xpv.2_RNA	NM_002027	NP_002018	P49354	FNTA_HUMAN	farnesyltransferase, CAAX box, alpha isoform a	27	Pro-rich.				cellular component disassembly involved in apoptosis|positive regulation of deacetylase activity|positive regulation of tubulin deacetylation|protein farnesylation|protein geranylgeranylation|transforming growth factor beta receptor signaling pathway	cytosol|microtubule associated complex	alpha-tubulin binding|CAAX-protein geranylgeranyltransferase activity|microtubule binding|protein farnesyltransferase activity			ovary(1)	1	Prostate(17;0.0119)|Ovarian(28;0.0172)|Lung SC(25;0.184)	all_cancers(86;0.000223)|all_epithelial(80;1.61e-07)|all_lung(54;0.00021)|Lung NSC(58;0.000778)|Hepatocellular(245;0.0524)|Renal(179;0.0822)|Esophageal squamous(32;0.129)	Lung(22;0.0777)|LUSC - Lung squamous cell carcinoma(45;0.17)			CCCCAGCCGCACCCACCGCCGC	0.748		NaN											NaN	NaN	NaN	NaN	NaN	5	4	---	---							
TSC1	7248	broad.mit.edu	37	9	135802666	135802666	+	Frame_Shift_Del	DEL	G	G	-			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08			G	-	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr9:135802666delG	uc004cca.2	-	4	366	c.132delC	c.(130-132)ACCfs	p.T44fs	TSC1_uc004ccb.3_Frame_Shift_Del_p.T44fs|TSC1_uc011mcq.1_Frame_Shift_Del_p.T44fs|TSC1_uc011mcr.1_Intron|TSC1_uc011mcs.1_Intron|TSC1_uc004ccc.1_Frame_Shift_Del_p.T44fs|TSC1_uc004ccd.2_Frame_Shift_Del_p.T44fs|TSC1_uc004cce.1_Frame_Shift_Del_p.T44fs	NM_000368	NP_000359	Q92574	TSC1_HUMAN	tuberous sclerosis 1 protein isoform 1	44					activation of Rho GTPase activity|cell cycle arrest|cell-matrix adhesion|insulin receptor signaling pathway|negative regulation of cell proliferation|negative regulation of protein ubiquitination|negative regulation of TOR signaling cascade|negative regulation of translation|positive regulation of focal adhesion assembly|regulation of phosphoprotein phosphatase activity|regulation of stress fiber assembly|rRNA export from nucleus	cell cortex|lamellipodium|membrane|TSC1-TSC2 complex	chaperone binding|protein N-terminus binding			lung(4)|central_nervous_system(3)|breast(2)|haematopoietic_and_lymphoid_tissue(1)|urinary_tract(1)|skin(1)|ovary(1)|bone(1)	14				OV - Ovarian serous cystadenocarcinoma(145;4.32e-08)|Epithelial(140;2.72e-06)		AATCCACCAAGGTGTTTACAA	0.448		NaN	D|Mis|N|F|S			hamartoma|renal cell			Tuberous_Sclerosis				NaN	NaN	NaN	NaN	NaN	33	13	---	---