Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	isArtifactMode	oxoGCut	pox	pox_cutoff	qox	t_alt_count	t_ref_count	validation_alt_allele	validation_tumor_sample							
RAP1GAP	5909	broad.mit.edu	37	1	21934840	21934840	+	Missense_Mutation	SNP	G	G	A			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr1:21934840G>A	uc001bex.2	-	17	1420	c.1162C>T	c.(1162-1164)CGG>TGG	p.R388W	RAP1GAP_uc001bev.2_Missense_Mutation_p.R388W|RAP1GAP_uc001bew.2_Missense_Mutation_p.R452W|RAP1GAP_uc001bey.2_Missense_Mutation_p.R388W	NM_002885	NP_002876	P47736	RPGP1_HUMAN	RAP1 GTPase activating protein isoform c	388	Rap-GAP.				regulation of Ras GTPase activity|signal transduction	cytosol|Golgi membrane|membrane fraction	GTPase activator activity|GTPase activity|protein homodimerization activity|Ras GTPase binding			breast(2)|ovary(1)	3		Colorectal(325;0.000147)|Renal(390;0.000734)|Lung NSC(340;0.000861)|all_lung(284;0.000901)|Breast(348;0.012)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0427)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0192)|OV - Ovarian serous cystadenocarcinoma(117;2.3e-26)|COAD - Colon adenocarcinoma(152;1.59e-05)|GBM - Glioblastoma multiforme(114;2.7e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000354)|STAD - Stomach adenocarcinoma(196;0.00645)|KIRC - Kidney renal clear cell carcinoma(1967;0.00862)|READ - Rectum adenocarcinoma(331;0.0625)|Lung(427;0.146)		GCCCGCGTCCGCTCCTGTGGG	0.647		NaN											0	0	0	0.004672	0	3	31									
TCHHL1	126637	broad.mit.edu	37	1	152058669	152058669	+	Missense_Mutation	SNP	C	C	G			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr1:152058669C>G	uc001ezo.1	-	3	1554	c.1489G>C	c.(1489-1491)GAA>CAA	p.E497Q		NM_001008536	NP_001008536	Q5QJ38	TCHL1_HUMAN	trichohyalin-like 1	497							calcium ion binding			ovary(1)|skin(1)	2	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.246)			TGTGTTCTTTCTCTTGCCCCC	0.478		NaN											0	0	0	0.017118	0	33	168									
FAM129A	116496	broad.mit.edu	37	1	184787960	184787960	+	Splice_Site	SNP	C	C	T			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr1:184787960C>T	uc001gra.2	-	9	1180	c.986_splice	c.e9-1	p.A329_splice	FAM129A_uc001grb.1_Splice_Site_p.A92_splice|FAM129A_uc009wyh.1_Splice_Site_p.A157_splice|FAM129A_uc009wyi.1_Splice_Site_p.A127_splice	NM_052966	NP_443198	Q9BZQ8	NIBAN_HUMAN	niban protein isoform 2						negative regulation of protein phosphorylation|positive regulation of protein phosphorylation|positive regulation of translation|response to endoplasmic reticulum stress	cytoplasm|nucleus|plasma membrane				ovary(3)|skin(1)	4						GCCACCATCGCTGAGGTAGGA	0.562		NaN											0	0	0	0.019004	0	33	114									
OBSCN	84033	broad.mit.edu	37	1	228462331	228462331	+	Silent	SNP	C	C	T			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr1:228462331C>T	uc009xez.1	+	20	5786	c.5742C>T	c.(5740-5742)GGC>GGT	p.G1914G	OBSCN_uc001hsn.2_Silent_p.G1914G	NM_001098623	NP_001092093	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and	1914	Ig-like 19.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			stomach(8)|large_intestine(7)|breast(5)|ovary(4)|skin(2)|central_nervous_system(1)|pancreas(1)	28		Prostate(94;0.0405)				AGGAGGGCGGCGAGGCCACCT	0.627		NaN											0	0	0	0.004482	0	7	16									
FAM188A	80013	broad.mit.edu	37	10	15863726	15863726	+	Splice_Site	SNP	C	C	T			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr10:15863726C>T	uc001iod.1	-	9	952	c.731_splice	c.e9-1	p.K244_splice	FAM188A_uc001ioe.1_Splice_Site_p.K71_splice|FAM188A_uc001iof.1_Splice_Site_p.K244_splice	NM_024948	NP_079224	Q9H8M7	F188A_HUMAN	chromosome 10 open reading frame 97						apoptosis	nucleus	calcium ion binding			ovary(1)	1						CCAAGAAGTTCTGCAAAAAAC	0.289		NaN											0	0	0	0.004482	0	8	28									
HRAS	3265	broad.mit.edu	37	11	534286	534286	+	Missense_Mutation	SNP	C	C	G	rs104894228		TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08			C	G	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr11:534286C>G	uc001lpv.2	-	2	225	c.37G>C	c.(37-39)GGT>CGT	p.G13R	HRAS_uc010qvw.1_Missense_Mutation_p.G13R|HRAS_uc010qvx.1_Missense_Mutation_p.G13R|HRAS_uc010qvy.1_RNA	NM_005343	NP_005334	P01112	RASH_HUMAN	v-Ha-ras Harvey rat sarcoma viral oncogene	13	GTP.		G -> D (in FCSS).|G -> C (in FCSS).		activation of MAPKK activity|axon guidance|blood coagulation|cell cycle arrest|cellular senescence|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|mitotic cell cycle G1/S transition checkpoint|negative regulation of cell proliferation|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of DNA replication|positive regulation of epithelial cell proliferation|Ras protein signal transduction|synaptic transmission	cytosol|Golgi membrane|plasma membrane	GTP binding|GTPase activity|protein C-terminus binding	p.G13R(34)|p.G13V(10)|p.G13D(9)|p.G13S(9)|p.G13C(6)|p.G13G(1)|p.G12_G13insAG(1)		urinary_tract(174)|thyroid(155)|skin(126)|upper_aerodigestive_tract(112)|soft_tissue(37)|prostate(29)|salivary_gland(24)|cervix(23)|stomach(14)|pituitary(10)|lung(9)|haematopoietic_and_lymphoid_tissue(9)|breast(6)|testis(5)|endometrium(4)|bone(3)|large_intestine(2)|oesophagus(2)|penis(2)|kidney(1)|adrenal_gland(1)|thymus(1)	749		all_cancers(49;4.37e-09)|all_epithelial(84;2.09e-06)|Breast(177;0.000162)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.0538)|all_lung(207;0.0713)		all cancers(45;7.63e-28)|Epithelial(43;7.29e-27)|OV - Ovarian serous cystadenocarcinoma(40;7.15e-21)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0375)|LUSC - Lung squamous cell carcinoma(625;0.0703)	Sulindac(DB00605)	TTGCCCACACCGCCGGCGCCC	0.642		6	Mis		infrequent sarcomas|rare other types	rhadomyosarcoma|ganglioneuroblastoma|bladder			Costello_syndrome	HNSCC(11;0.0054)			0	0	0	0.006122	0	18	10									
TRIM68	55128	broad.mit.edu	37	11	4621770	4621770	+	Silent	SNP	C	C	G			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr11:4621770C>G	uc001lzf.1	-	7	1432	c.1194G>C	c.(1192-1194)CTG>CTC	p.L398L	TRIM68_uc001lzg.1_Silent_p.L175L|TRIM68_uc010qyj.1_RNA	NM_018073	NP_060543	Q6AZZ1	TRI68_HUMAN	ring finger protein 137	398	B30.2/SPRY.				protein autoubiquitination|regulation of androgen receptor signaling pathway	Golgi apparatus|nucleolus|perinuclear region of cytoplasm	androgen receptor binding|histone acetyltransferase binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)	1		Medulloblastoma(188;0.0025)|Breast(177;0.0101)|all_neural(188;0.0227)		Epithelial(150;9.49e-12)|BRCA - Breast invasive adenocarcinoma(625;0.0288)|LUSC - Lung squamous cell carcinoma(625;0.192)		TTCCCTTCCTCAGCCTTATCA	0.557		NaN											0	0	0	0.020292	0	12	41									
C11orf58	10944	broad.mit.edu	37	11	16774368	16774368	+	Missense_Mutation	SNP	C	C	G			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr11:16774368C>G	uc001mmk.2	+	4	423	c.245C>G	c.(244-246)TCT>TGT	p.S82C	C11orf58_uc010rct.1_Missense_Mutation_p.S38C	NM_014267	NP_055082	O00193	SMAP_HUMAN	small acidic protein isoform a	82											0						GAACTGGAGTCTCAATATCAG	0.348		NaN											0	0	0	0.013114	0	42	7									
PTPRJ	5795	broad.mit.edu	37	11	48158582	48158582	+	Missense_Mutation	SNP	T	T	C			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr11:48158582T>C	uc001ngp.3	+	10	2256	c.1901T>C	c.(1900-1902)GTA>GCA	p.V634A	PTPRJ_uc010rhr.1_Missense_Mutation_p.V79A	NM_002843	NP_002834	Q12913	PTPRJ_HUMAN	protein tyrosine phosphatase, receptor type, J	634	Extracellular (Potential).|Fibronectin type-III 7.				contact inhibition|negative regulation of cell growth|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of MAP kinase activity|negative regulation of platelet-derived growth factor receptor signaling pathway|negative regulation of protein kinase B signaling cascade|negative regulation of T cell receptor signaling pathway|negative regulation of vascular permeability|platelet-derived growth factor receptor signaling pathway|positive chemotaxis|positive regulation of focal adhesion assembly|positive regulation of protein kinase B signaling cascade|positive regulation of survival gene product expression	cell surface|cell-cell junction|immunological synapse|integral to plasma membrane|ruffle membrane	beta-catenin binding|delta-catenin binding|gamma-catenin binding|mitogen-activated protein kinase binding|platelet-derived growth factor receptor binding|protein tyrosine phosphatase activity			breast(3)|kidney(3)|ovary(1)|skin(1)	8						AACATTGATGTAAGTACCAAC	0.408		NaN											0	0	0	0.00499	0	12	52									
OR5D13	390142	broad.mit.edu	37	11	55541619	55541619	+	Missense_Mutation	SNP	C	C	T			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr11:55541619C>T	uc010ril.1	+	1	706	c.706C>T	c.(706-708)CGC>TGC	p.R236C		NM_001001967	NP_001001967	Q8NGL4	OR5DD_HUMAN	olfactory receptor, family 5, subfamily D,	236	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|pancreas(1)|skin(1)	3		all_epithelial(135;0.196)				TGCAAGTGGGCGCCAGAAAAC	0.408		NaN											0	0	0	0.016522	0	19	58									
ARAP1	116985	broad.mit.edu	37	11	72412694	72412694	+	Missense_Mutation	SNP	C	C	G			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr11:72412694C>G	uc001osu.2	-	16	2491	c.2302G>C	c.(2302-2304)GAG>CAG	p.E768Q	ARAP1_uc001osv.2_Missense_Mutation_p.E768Q|ARAP1_uc001osr.2_Missense_Mutation_p.E528Q|ARAP1_uc001oss.2_Missense_Mutation_p.E523Q|ARAP1_uc009yth.2_Missense_Mutation_p.E462Q|ARAP1_uc010rre.1_Missense_Mutation_p.E523Q|ARAP1_uc001osw.1_Missense_Mutation_p.E56Q	NM_001040118	NP_001035207	Q96P48	ARAP1_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH	768	PH 3.				actin filament reorganization involved in cell cycle|negative regulation of stress fiber assembly|positive regulation of Cdc42 GTPase activity|positive regulation of filopodium assembly|regulation of ARF GTPase activity|regulation of cell shape|regulation of cellular component movement|small GTPase mediated signal transduction	cytosol|Golgi cisterna membrane|plasma membrane	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|protein binding|Rho GTPase activator activity|zinc ion binding			skin(1)	1						TGGCACCCACCTTCCCGGGCC	0.632		NaN											0	0	0	0.028581	0	15	120									
SORL1	6653	broad.mit.edu	37	11	121481797	121481797	+	Missense_Mutation	SNP	C	C	T			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr11:121481797C>T	uc001pxx.2	+	39	5332	c.5252C>T	c.(5251-5253)CCA>CTA	p.P1751L	SORL1_uc010rzp.1_Missense_Mutation_p.P597L|SORL1_uc010rzq.1_Missense_Mutation_p.P366L	NM_003105	NP_003096	Q92673	SORL_HUMAN	sortilin-related receptor containing LDLR class	1751	Extracellular (Potential).|Fibronectin type-III 3.				cholesterol metabolic process|lipid transport|receptor-mediated endocytosis	integral to plasma membrane|low-density lipoprotein particle	low-density lipoprotein particle binding|transmembrane receptor activity			ovary(5)|breast(4)|large_intestine(2)|skin(2)|central_nervous_system(1)|pancreas(1)	15		Breast(109;0.00119)|Medulloblastoma(222;0.0429)|all_neural(223;0.113)		BRCA - Breast invasive adenocarcinoma(274;3.34e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.108)		ATCCCACCACCAGATATCCAC	0.418		NaN											0	0	0	0.012213	0	29	55									
C11orf63	79864	broad.mit.edu	37	11	122756598	122756598	+	Missense_Mutation	SNP	C	C	A			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr11:122756598C>A	uc001pym.2	+	2	338	c.41C>A	c.(40-42)TCT>TAT	p.S14Y	C11orf63_uc001pyl.1_Missense_Mutation_p.S14Y	NM_024806	NP_079082	Q6NUN7	CK063_HUMAN	hypothetical protein LOC79864 isoform 1	14										ovary(3)	3		Breast(109;0.00249)|Lung NSC(97;0.0177)|all_lung(97;0.018)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;5.34e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0311)		TCTATTCAATCTCCTGTCCTT	0.393		NaN											1	0	4.26978e-12	0.01892	4.71455e-12	21	63									
ARID2	196528	broad.mit.edu	37	12	46245523	46245523	+	Missense_Mutation	SNP	C	C	T			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr12:46245523C>T	uc001ros.1	+	15	3617	c.3617C>T	c.(3616-3618)ACG>ATG	p.T1206M	ARID2_uc001ror.2_Missense_Mutation_p.T1206M|ARID2_uc009zkg.1_Missense_Mutation_p.T662M|ARID2_uc009zkh.1_Missense_Mutation_p.T833M|ARID2_uc001rou.1_Missense_Mutation_p.T540M	NM_152641	NP_689854	Q68CP9	ARID2_HUMAN	AT rich interactive domain 2 (ARID, RFX-like)	1206					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(6)|skin(3)|upper_aerodigestive_tract(1)	10	Lung SC(27;0.192)|Renal(347;0.236)	Lung NSC(34;0.106)|all_lung(34;0.22)	OV - Ovarian serous cystadenocarcinoma(5;0.00691)	GBM - Glioblastoma multiforme(48;0.0153)		ATGAGCGGAACGCAGACAGGA	0.488		NaN											0	0	0	0.016723	0	13	15									
HOXC13	3229	broad.mit.edu	37	12	54339012	54339012	+	Missense_Mutation	SNP	C	C	T			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr12:54339012C>T	uc001sei.2	+	2	1080	c.965C>T	c.(964-966)TCG>TTG	p.S322L	HOXC13_uc010sop.1_RNA	NM_017410	NP_059106	P31276	HXC13_HUMAN	homeobox C13	322						nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)	1						GTCAGCAAATCGAAAGCGCCT	0.577		NaN	T	NUP98	AML								0	0	0	0.016723	0	13	189									
UBE3B	89910	broad.mit.edu	37	12	109927742	109927742	+	Missense_Mutation	SNP	C	C	T			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr12:109927742C>T	uc001top.2	+	8	1166	c.563C>T	c.(562-564)GCG>GTG	p.A188V	UBE3B_uc001toq.2_Missense_Mutation_p.A188V|UBE3B_uc001tol.1_Missense_Mutation_p.A188V|UBE3B_uc001tom.2_Missense_Mutation_p.A188V|UBE3B_uc001ton.2_Missense_Mutation_p.A188V|UBE3B_uc001too.1_RNA|UBE3B_uc009zvj.1_Missense_Mutation_p.A188V|UBE3B_uc001tor.2_Missense_Mutation_p.A188V	NM_130466	NP_569733	Q7Z3V4	UBE3B_HUMAN	ubiquitin protein ligase E3B	188					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	intracellular	ubiquitin-protein ligase activity			ovary(2)|lung(2)	4						CTTCGACCAGCGATGAACCAC	0.443		NaN											0	0	0	0.00499	0	15	188									
KDM2B	84678	broad.mit.edu	37	12	121882333	121882333	+	Nonsense_Mutation	SNP	C	C	A			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr12:121882333C>A	uc001uat.2	-	15	2214	c.2110G>T	c.(2110-2112)GAG>TAG	p.E704*	KDM2B_uc001uaq.2_Nonsense_Mutation_p.E144*|KDM2B_uc010szy.1_Nonsense_Mutation_p.E144*|KDM2B_uc001uar.2_Nonsense_Mutation_p.E295*|KDM2B_uc001uas.2_Nonsense_Mutation_p.E673*|KDM2B_uc001uau.2_Intron|KDM2B_uc001uao.2_5'Flank|KDM2B_uc010szx.1_5'Flank|KDM2B_uc001uap.2_5'Flank	NM_032590	NP_115979	Q8NHM5	KDM2B_HUMAN	F-box and leucine-rich repeat protein 10 isoform	704	PHD-type.				embryonic camera-type eye morphogenesis|fourth ventricle development|histone H2A monoubiquitination|initiation of neural tube closure|lateral ventricle development|midbrain development|midbrain-hindbrain boundary morphogenesis|negative regulation of neural precursor cell proliferation|negative regulation of neuron apoptosis|negative regulation of transcription from RNA polymerase II promoter|spermatogenesis|third ventricle development|transcription, DNA-dependent	nucleolus	DNA binding|histone demethylase activity (H3-K36 specific)|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|rRNA binding|zinc ion binding			ovary(1)|skin(1)	2						CCCTCTGACTCCTTAATCTGC	0.602		NaN											1	0	0.00400662	0.028581	0.00420497	14	101									
OTUD7A	161725	broad.mit.edu	37	15	31818621	31818621	+	Missense_Mutation	SNP	G	G	A			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr15:31818621G>A	uc001zfq.2	-	6	896	c.803C>T	c.(802-804)ACG>ATG	p.T268M	OTUD7A_uc001zfr.2_Missense_Mutation_p.T275M	NM_130901	NP_570971	Q8TE49	OTU7A_HUMAN	OTU domain containing 7A	268	OTU.|Catalytic (By similarity).|TRAF-binding (By similarity).					cytoplasm|nucleus	cysteine-type peptidase activity|DNA binding|zinc ion binding			pancreas(1)|skin(1)	2		all_lung(180;1.6e-09)		all cancers(64;2.44e-19)|Epithelial(43;6.82e-14)|GBM - Glioblastoma multiforme(186;1.49e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00189)|Lung(196;0.208)		CAGCAGCTCCGTCCACTCCCG	0.682		NaN											0	0	0	0.004482	0	7	35									
ARHGAP11A	9824	broad.mit.edu	37	15	32929352	32929352	+	Missense_Mutation	SNP	A	A	T			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr15:32929352A>T	uc001zgy.1	+	12	3100	c.2378A>T	c.(2377-2379)AAA>ATA	p.K793I	ARHGAP11A_uc010ubw.1_Missense_Mutation_p.K604I|ARHGAP11A_uc010ubx.1_Missense_Mutation_p.K604I	NM_014783	NP_055598	Q6P4F7	RHGBA_HUMAN	Rho GTPase activating protein 11A isoform 1	793					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			skin(3)|breast(2)|urinary_tract(1)	6		all_lung(180;1.3e-11)		all cancers(64;3.34e-21)|Epithelial(43;2.64e-15)|GBM - Glioblastoma multiforme(186;5.17e-06)|BRCA - Breast invasive adenocarcinoma(123;0.00112)|Lung(196;0.227)		ACATGTGAGAAAACAGTTTCT	0.348		NaN											0	0	0	0.024245	0	14	49									
WDR72	256764	broad.mit.edu	37	15	53994342	53994342	+	Missense_Mutation	SNP	C	C	T			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr15:53994342C>T	uc002acj.2	-	12	1600	c.1558G>A	c.(1558-1560)GAG>AAG	p.E520K	WDR72_uc010bfi.1_Missense_Mutation_p.E520K	NM_182758	NP_877435	Q3MJ13	WDR72_HUMAN	WD repeat domain 72	520	WD 7.									lung(1)|skin(1)	2				all cancers(107;0.0511)		TTAAACTTCTCTGGTGACATC	0.294		NaN											0	0	0	0.010729	0	10	64									
LDHAL6B	92483	broad.mit.edu	37	15	59499546	59499546	+	Missense_Mutation	SNP	C	C	G			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr15:59499546C>G	uc002agb.2	+	1	505	c.407C>G	c.(406-408)GCA>GGA	p.A136G	MYO1E_uc002aga.2_Intron	NM_033195	NP_149972	Q9BYZ2	LDH6B_HUMAN	lactate dehydrogenase A-like 6B	136					glycolysis	cytoplasm	L-lactate dehydrogenase activity|protein binding				0					NADH(DB00157)	TTTGTCACAGCAAACTCCAAC	0.433		NaN											0	0	0	0.027356	0	26	80									
CYP11A1	1583	broad.mit.edu	37	15	74637457	74637457	+	Missense_Mutation	SNP	G	G	A			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr15:74637457G>A	uc002axt.2	-	3	708	c.553C>T	c.(553-555)CGC>TGC	p.R185C	CYP11A1_uc002axs.2_Missense_Mutation_p.R27C|CYP11A1_uc010bjm.1_Missense_Mutation_p.R27C|CYP11A1_uc010bjn.1_RNA|CYP11A1_uc010bjo.1_Missense_Mutation_p.R185C|CYP11A1_uc010bjp.1_5'Flank|CYP11A1_uc010ulj.1_Intron|CYP11A1_uc010bjq.2_Missense_Mutation_p.R185C	NM_000781	NP_000772	P05108	CP11A_HUMAN	cytochrome P450, family 11, subfamily A,	185					C21-steroid hormone biosynthetic process|cholesterol metabolic process|vitamin D metabolic process|xenobiotic metabolic process	mitochondrial matrix	cholesterol monooxygenase (side-chain-cleaving) activity|electron carrier activity|heme binding			ovary(2)	2					Aminoglutethimide(DB00357)|Cholecalciferol(DB00169)|Cimetidine(DB00501)|Clotrimazole(DB00257)|Digitoxin(DB01396)|Digoxin(DB00390)|Medroxyprogesterone(DB00603)|Ouabain(DB01092)|Progesterone(DB00396)|Testosterone(DB00624)|Trilostane(DB01108)	TTCTTGATGCGCCTGTGCAGG	0.582		NaN											0	0	0	0.014758	0	4	69									
RBBP6	5930	broad.mit.edu	37	16	24573026	24573026	+	Missense_Mutation	SNP	T	T	G			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr16:24573026T>G	uc002dmh.2	+	9	1981	c.941T>G	c.(940-942)TTT>TGT	p.F314C	RBBP6_uc010vcb.1_Missense_Mutation_p.F181C|RBBP6_uc002dmi.2_Missense_Mutation_p.F314C|RBBP6_uc010bxr.2_Missense_Mutation_p.F314C|RBBP6_uc002dmk.2_Missense_Mutation_p.F181C	NM_006910	NP_008841	Q7Z6E9	RBBP6_HUMAN	retinoblastoma-binding protein 6 isoform 1	314					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	chromosome|nucleolus|ubiquitin ligase complex	nucleic acid binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(3)|pancreas(1)	4				GBM - Glioblastoma multiforme(48;0.0518)		GCCAATAAATTTTTACGACAG	0.333		NaN											0	0	0	0.014758	0	5	60									
ZNF629	23361	broad.mit.edu	37	16	30794836	30794836	+	Silent	SNP	G	G	A			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr16:30794836G>A	uc002dzs.1	-	3	1021	c.813C>T	c.(811-813)TTC>TTT	p.F271F		NM_001080417	NP_001073886	Q9UEG4	ZN629_HUMAN	zinc finger protein 629	271	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0			Colorectal(24;0.198)			AGCTGCGGTAGAAAGCCCGGC	0.632		NaN											0	0	0	0.020292	0	13	33									
CMTM2	146225	broad.mit.edu	37	16	66621938	66621938	+	Silent	SNP	A	A	G			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr16:66621938A>G	uc002ept.2	+	4	823	c.663A>G	c.(661-663)AAA>AAG	p.K221K	CMTM2_uc010cdu.2_Silent_p.K168K	NM_144673	NP_653274	Q8TAZ6	CKLF2_HUMAN	chemokine-like factor superfamily 2	221					chemotaxis	extracellular space|integral to membrane	cytokine activity			ovary(1)	1		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.068)|Epithelial(162;0.212)		GAAAGGAAAAAGGACCCCAGC	0.522		NaN											0	0	0	0.004672	0	3	73									
AP1G1	164	broad.mit.edu	37	16	71798289	71798289	+	Missense_Mutation	SNP	C	C	G			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr16:71798289C>G	uc010cgg.2	-	9	1196	c.882G>C	c.(880-882)TTG>TTC	p.L294F	AP1G1_uc002fba.2_Missense_Mutation_p.L297F|AP1G1_uc002fbb.2_Missense_Mutation_p.L317F|AP1G1_uc010vmg.1_RNA	NM_001128	NP_001119	O43747	AP1G1_HUMAN	adaptor-related protein complex 1, gamma 1	294					endocytosis|intracellular protein transport|post-Golgi vesicle-mediated transport|regulation of defense response to virus by virus|viral reproduction	clathrin adaptor complex|clathrin coated vesicle membrane|cytosol|Golgi membrane|lysosomal membrane|recycling endosome	kinesin binding|protein transporter activity			ovary(2)	2		Ovarian(137;0.125)				CCATGATAGTCAAAACCGTTT	0.363		NaN											0	0	0	0.00308	0	7	31									
GEMIN4	50628	broad.mit.edu	37	17	650821	650821	+	Silent	SNP	G	G	A	rs151264305	by1000genomes	TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr17:650821G>A	uc002frs.1	-	2	581	c.462C>T	c.(460-462)GCC>GCT	p.A154A	GEMIN4_uc010vqa.1_Silent_p.A154A	NM_015721	NP_056536	P57678	GEMI4_HUMAN	gemin 4	154					rRNA processing|spliceosomal snRNP assembly	Cajal body|cytosol|nucleolus|small nuclear ribonucleoprotein complex|spliceosomal complex	protein binding			ovary(2)|kidney(1)|skin(1)	4		Myeloproliferative disorder(207;0.204)		UCEC - Uterine corpus endometrioid carcinoma (25;0.022)		CCACGTCTTCGGCAGAAGTGT	0.567		NaN											0	0	0	0.00308	0	7	75									
DLG4	1742	broad.mit.edu	37	17	7094110	7094110	+	Missense_Mutation	SNP	C	C	T			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr17:7094110C>T	uc002get.3	-	22	3422	c.2221G>A	c.(2221-2223)GAG>AAG	p.E741K	DLG4_uc010vtm.1_RNA|DLG4_uc010vtn.1_Missense_Mutation_p.E638K|DLG4_uc010cly.2_Missense_Mutation_p.E695K|DLG4_uc010vto.1_Missense_Mutation_p.E738K	NM_001365	NP_001356	P78352	DLG4_HUMAN	post-synaptic density protein 95 isoform 1	698	Guanylate kinase-like.				axon guidance|learning|protein complex assembly|protein localization to synapse|signal transduction|synaptic transmission	cell junction|cortical cytoskeleton|endocytic vesicle membrane|neuron spine|postsynaptic density|postsynaptic membrane|synaptosome	protein binding|protein C-terminus binding			ovary(1)|breast(1)	2						TAGATCTCCTCAAAGCTGTCA	0.557		NaN											0	0	0	0.01892	0	23	58									
MYH10	4628	broad.mit.edu	37	17	8393774	8393774	+	Missense_Mutation	SNP	C	C	G			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr17:8393774C>G	uc002gll.2	-	33	4771	c.4675G>C	c.(4675-4677)GAA>CAA	p.E1559Q	MYH10_uc002glm.2_Missense_Mutation_p.E1590Q|MYH10_uc010cnx.2_Missense_Mutation_p.E1568Q	NM_005964	NP_005955	P35580	MYH10_HUMAN	myosin, heavy polypeptide 10, non-muscle	1559	Potential.				actin filament-based movement|axon guidance|cytokinesis after mitosis|regulation of cell shape	cell cortex|cleavage furrow|midbody|myosin complex|stress fiber	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(2)	2						TTGGCATCTTCCGTGGCCTGG	0.542		NaN											0	0	0	0.009096	0	3	96									
MYH10	4628	broad.mit.edu	37	17	8449973	8449973	+	Silent	SNP	C	C	T			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr17:8449973C>T	uc002gll.2	-	11	1233	c.1137G>A	c.(1135-1137)CAG>CAA	p.Q379Q	MYH10_uc002glm.2_Silent_p.Q389Q|MYH10_uc010cnx.2_Silent_p.Q388Q	NM_005964	NP_005955	P35580	MYH10_HUMAN	myosin, heavy polypeptide 10, non-muscle	379	Myosin head-like.				actin filament-based movement|axon guidance|cytokinesis after mitosis|regulation of cell shape	cell cortex|cleavage furrow|midbody|myosin complex|stress fiber	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(2)	2						GGCAGAGCTTCTGCGCAACTG	0.418		NaN											0	0	0	0.010729	0	9	28									
MPRIP	23164	broad.mit.edu	37	17	17083384	17083384	+	Silent	SNP	C	C	T			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr17:17083384C>T	uc002gqu.1	+	22	3083	c.3027C>T	c.(3025-3027)CTC>CTT	p.L1009L	MPRIP_uc002gqv.1_Silent_p.L1009L|MPRIP_uc002gqw.1_Silent_p.L764L|MPRIP_uc002gqx.1_Silent_p.L1238L|MPRIP_uc002gqy.1_Silent_p.L1238L|MPRIP_uc010cpl.1_Silent_p.L195L|MPRIP_uc010cpm.1_Silent_p.L195L	NM_201274	NP_958431	Q6WCQ1	MPRIP_HUMAN	myosin phosphatase-Rho interacting protein	1009						cytoplasm|cytoskeleton	actin binding				0						CCCGGCAACTCAGAAACATCA	0.488		NaN											0	0	0	0.021553	0	5	25									
MPRIP	23164	broad.mit.edu	37	17	17083388	17083388	+	Missense_Mutation	SNP	A	A	C			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr17:17083388A>C	uc002gqu.1	+	22	3087	c.3031A>C	c.(3031-3033)AAC>CAC	p.N1011H	MPRIP_uc002gqv.1_Missense_Mutation_p.N1011H|MPRIP_uc002gqw.1_Missense_Mutation_p.N766H|MPRIP_uc002gqx.1_Missense_Mutation_p.N1240H|MPRIP_uc002gqy.1_Missense_Mutation_p.N1240H|MPRIP_uc010cpl.1_Missense_Mutation_p.N197H|MPRIP_uc010cpm.1_Missense_Mutation_p.N197H	NM_201274	NP_958431	Q6WCQ1	MPRIP_HUMAN	myosin phosphatase-Rho interacting protein	1011						cytoplasm|cytoskeleton	actin binding				0						GCAACTCAGAAACATCAGGTC	0.493		NaN											0	0	0	0.021553	0	5	25									
ZNF207	7756	broad.mit.edu	37	17	30696342	30696342	+	Missense_Mutation	SNP	A	A	G			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr17:30696342A>G	uc002hhh.3	+	10	1293	c.1145A>G	c.(1144-1146)TAT>TGT	p.Y382C	ZNF207_uc002hhj.3_Missense_Mutation_p.Y398C|ZNF207_uc002hhi.3_Missense_Mutation_p.Y367C|ZNF207_uc010csz.2_Missense_Mutation_p.Y401C|ZNF207_uc002hhk.1_Missense_Mutation_p.Y398C|ZNF207_uc002hhl.1_RNA	NM_003457	NP_003448	O43670	ZN207_HUMAN	zinc finger protein 207 isoform a	382						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Breast(31;0.116)|Ovarian(249;0.182)	BRCA - Breast invasive adenocarcinoma(9;0.239)			TTACCTAAGTATCAACGTAAT	0.502		NaN											0	0	0	0.007291	0	24	32									
CDK5R1	8851	broad.mit.edu	37	17	30815244	30815244	+	Silent	SNP	C	C	T			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr17:30815244C>T	uc002hhn.2	+	2	827	c.606C>T	c.(604-606)GTC>GTT	p.V202V	CDK5R1_uc010wca.1_Silent_p.V202V|CDK5R1_uc010ctc.2_Intron	NM_003885	NP_003876	Q15078	CD5R1_HUMAN	cyclin-dependent kinase 5, regulatory subunit 1	202					axon guidance|axonal fasciculation|brain development|cell proliferation|embryo development|ionotropic glutamate receptor signaling pathway|muscarinic acetylcholine receptor signaling pathway|negative regulation of transcription, DNA-dependent|neuron cell-cell adhesion|neuron migration|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of neuron apoptosis|regulation of cyclin-dependent protein kinase activity|regulation of neuron differentiation	axon|contractile fiber|cyclin-dependent protein kinase 5 holoenzyme complex|cytosol|dendritic spine|growth cone|neuromuscular junction|neuronal cell body|perinuclear region of cytoplasm|plasma membrane	cadherin binding|calcium ion binding|protein kinase binding			ovary(1)	1		Breast(31;0.159)|Ovarian(249;0.182)	BRCA - Breast invasive adenocarcinoma(9;0.0938)			CCAACGTGGTCTTCCTCTACA	0.642		NaN											0	0	0	0.020292	0	14	91									
TBX4	9496	broad.mit.edu	37	17	59534930	59534930	+	Missense_Mutation	SNP	G	G	C			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr17:59534930G>C	uc002izi.2	+	2	264	c.219G>C	c.(217-219)GAG>GAC	p.E73D	TBX4_uc010ddo.2_Missense_Mutation_p.E73D|TBX4_uc010woy.1_Missense_Mutation_p.E73D	NM_018488	NP_060958	P57082	TBX4_HUMAN	T-box 4	73	T-box.				leg morphogenesis|skeletal system morphogenesis	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			skin(2)	2						GGCTGCATGAGAAGGAGCTCT	0.597		NaN											0	0	0	0.004482	0	6	56									
POLRMT	5442	broad.mit.edu	37	19	630113	630113	+	Silent	SNP	C	C	T			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr19:630113C>T	uc002lpf.1	-	3	305	c.249G>A	c.(247-249)GTG>GTA	p.V83V		NM_005035	NP_005026	O00411	RPOM_HUMAN	mitochondrial DNA-directed RNA polymerase	83					transcription initiation from mitochondrial promoter	mitochondrial nucleoid	DNA binding|DNA-directed RNA polymerase activity|protein binding			ovary(1)|pancreas(1)	2		all_epithelial(18;2.78e-22)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;3.55e-06)|all_lung(49;5.41e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CCACCCTGTTCACCACCACCT	0.672		NaN											0	0	0	0.007413	0	18	86									
ATP8B3	148229	broad.mit.edu	37	19	1789016	1789016	+	Silent	SNP	C	C	G			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr19:1789016C>G	uc002ltw.2	-	24	3183	c.2949G>C	c.(2947-2949)CTG>CTC	p.L983L	ATP8B3_uc002ltv.2_Silent_p.L946L|ATP8B3_uc002ltx.2_RNA	NM_138813	NP_620168	O60423	AT8B3_HUMAN	ATPase, class I, type 8B, member 3	983	Cytoplasmic (Potential).				ATP biosynthetic process		ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GGCCGTGCACCAGCAGGAGGC	0.632		NaN											0	0	0	0.021553	0	5	11									
MUC16	94025	broad.mit.edu	37	19	9018160	9018160	+	Missense_Mutation	SNP	T	T	C			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr19:9018160T>C	uc002mkp.2	-	25	37982	c.37778A>G	c.(37777-37779)TAC>TGC	p.Y12593C		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	12595	SEA 4.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GCAGCCAGAGTACAGAAGGCC	0.537		NaN											0	0	0	0.013726	0	29	99									
TSSK6	83983	broad.mit.edu	37	19	19626255	19626255	+	Translation_Start_Site	SNP	C	C	T			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr19:19626255C>T	uc002nmr.2	-	1	215	c.-18G>A	c.(-20--16)CCGTG>CCATG		TSSK6_uc002nmq.2_RNA|NDUFA13_uc002nms.2_5'Flank|NDUFA13_uc010xqx.1_5'Flank|NDUFA13_uc010xqy.1_5'Flank	NM_032037	NP_114426	Q9BXA6	TSSK6_HUMAN	testis-specific serine kinase 6						multicellular organismal development|sperm chromatin condensation		ATP binding|magnesium ion binding|protein serine/threonine kinase activity			stomach(1)	1						CTAGGGCGCACGGGGGGCAGG	0.652		NaN											0	0	0	0.008291	0	9	21									
ZNF677	342926	broad.mit.edu	37	19	53740952	53740952	+	Missense_Mutation	SNP	C	C	G			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr19:53740952C>G	uc002qbf.1	-	5	1213	c.1028G>C	c.(1027-1029)GGA>GCA	p.G343A	ZNF677_uc002qbg.1_Missense_Mutation_p.G343A	NM_182609	NP_872415	Q86XU0	ZN677_HUMAN	zinc finger protein 677	343					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1				GBM - Glioblastoma multiforme(134;0.00352)		AGGTTTCTCTCCAGTATGCAT	0.388		NaN											0	0	0	0.001984	0	6	41									
ZNF749	388567	broad.mit.edu	37	19	57955885	57955885	+	Missense_Mutation	SNP	C	C	G			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr19:57955885C>G	uc002qoq.2	+	3	1623	c.1369C>G	c.(1369-1371)CAG>GAG	p.Q457E	ZNF547_uc002qpm.3_Intron	NM_001023561	NP_001018855	O43361	ZN749_HUMAN	zinc finger protein 749	457	C2H2-type 10.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.221)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0264)|Lung(386;0.177)		AGTTCAGCACCAGAAAATCCA	0.423		NaN											0	0	0	0.009096	0	3	71									
SMEK2	57223	broad.mit.edu	37	2	55791550	55791550	+	Missense_Mutation	SNP	T	T	A			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr2:55791550T>A	uc002rzc.2	-	15	2534	c.2159A>T	c.(2158-2160)GAT>GTT	p.D720V	SMEK2_uc002rzb.2_Missense_Mutation_p.D635V|SMEK2_uc002rzd.2_Missense_Mutation_p.D688V|SMEK2_uc002ryz.2_Missense_Mutation_p.D147V|SMEK2_uc002rza.2_Missense_Mutation_p.D504V	NM_001122964	NP_001116436	Q5MIZ7	P4R3B_HUMAN	SMEK homolog 2, suppressor of mek1 isoform 1	720	Poly-Glu.					microtubule organizing center|nucleus	protein binding			skin(1)	1			LUSC - Lung squamous cell carcinoma(58;0.127)|Lung(47;0.132)			CTCTTCTTCATCTTCATTAAA	0.358		NaN											0	0	0	0.020292	0	13	27									
FAM119A	151194	broad.mit.edu	37	2	208477805	208477805	+	Missense_Mutation	SNP	C	C	T			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr2:208477805C>T	uc002vcf.2	-	4	782	c.622G>A	c.(622-624)GAA>AAA	p.E208K	FAM119A_uc002vce.2_Intron|FAM119A_uc010fuk.1_Missense_Mutation_p.E208K|FAM119A_uc002vcg.3_Missense_Mutation_p.E208K	NM_145280	NP_660323	Q8WXB1	MT21A_HUMAN	hypothetical protein LOC151194	208						integral to membrane	methyltransferase activity				0				LUSC - Lung squamous cell carcinoma(261;0.0705)|Epithelial(149;0.131)|Lung(261;0.135)		TTCTGTGCTTCGTAAATATGT	0.368		NaN											0	0	0	0.010504	0	21	70									
TGM6	343641	broad.mit.edu	37	20	2413265	2413265	+	Silent	SNP	C	C	T			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr20:2413265C>T	uc002wfy.1	+	13	2158	c.2097C>T	c.(2095-2097)ATC>ATT	p.I699I	TGM6_uc010gal.1_3'UTR	NM_198994	NP_945345	O95932	TGM3L_HUMAN	transglutaminase 6	699					cell death|peptide cross-linking		acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			ovary(3)|skin(1)	4					L-Glutamine(DB00130)	GCTTTGTGATCGTCCATGTGG	0.552		NaN											0	0	0	0.00499	0	16	95									
CTCFL	140690	broad.mit.edu	37	20	56093885	56093885	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr20:56093885G>A	uc010gix.1	-	4	1650	c.988C>T	c.(988-990)CGA>TGA	p.R330*	CTCFL_uc010giw.1_Nonsense_Mutation_p.R330*|CTCFL_uc002xym.2_Nonsense_Mutation_p.R330*|CTCFL_uc010giz.1_5'UTR|CTCFL_uc010giy.1_5'UTR|CTCFL_uc010gja.1_Nonsense_Mutation_p.R330*|CTCFL_uc010gjb.1_Nonsense_Mutation_p.R330*|CTCFL_uc010gjc.1_Nonsense_Mutation_p.R330*|CTCFL_uc010gjd.1_Nonsense_Mutation_p.R330*|CTCFL_uc010gje.2_Nonsense_Mutation_p.R330*|CTCFL_uc010gjf.2_Nonsense_Mutation_p.R125*|CTCFL_uc010gjg.2_Nonsense_Mutation_p.R62*|CTCFL_uc010gjh.1_Nonsense_Mutation_p.R330*|CTCFL_uc010gji.1_Nonsense_Mutation_p.R125*|CTCFL_uc010gjj.1_Nonsense_Mutation_p.R330*|CTCFL_uc010gjk.1_Nonsense_Mutation_p.R330*|CTCFL_uc010gjl.1_Nonsense_Mutation_p.R330*	NM_080618	NP_542185	Q8NI51	CTCFL_HUMAN	CCCTC-binding factor-like protein	330	C2H2-type 3.				cell cycle|DNA methylation involved in gamete generation|histone methylation|positive regulation of transcription, DNA-dependent|regulation of gene expression by genetic imprinting|regulation of histone H3-K4 methylation|transcription, DNA-dependent	cytoplasm|nucleus	histone binding|sequence-specific DNA binding|transcription regulatory region DNA binding|zinc ion binding			ovary(2)|large_intestine(1)|skin(1)	4	Lung NSC(12;0.00132)|all_lung(29;0.00433)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(13;3.95e-12)|Epithelial(14;3.41e-08)|all cancers(14;2.09e-07)			CGCCTGTGTCGGACGAGTTCT	0.433		NaN											0	0	0	0.00308	0	7	96									
SYNJ1	8867	broad.mit.edu	37	21	34011221	34011221	+	Silent	SNP	C	C	T			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr21:34011221C>T	uc002yqh.2	-	31	4029	c.4029G>A	c.(4027-4029)CCG>CCA	p.P1343P	SYNJ1_uc011ads.1_Silent_p.P1257P|SYNJ1_uc002yqf.2_Silent_p.P1288P|SYNJ1_uc002yqg.2_Silent_p.P1257P|SYNJ1_uc002yqi.2_Silent_p.P1343P|SYNJ1_uc002yqe.3_5'UTR	NM_003895	NP_003886	O43426	SYNJ1_HUMAN	synaptojanin 1 isoform a	1304	Pro-rich.						inositol-polyphosphate 5-phosphatase activity|nucleotide binding|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|RNA binding	p.P1304P(1)		ovary(4)|skin(1)	5						GACTTACTTGCGGTTGTGAGG	0.408		NaN											0	0	0	0.00308	0	4	147									
TCF20	6942	broad.mit.edu	37	22	42610592	42610592	+	Silent	SNP	G	G	A			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr22:42610592G>A	uc003bcj.1	-	1	854	c.720C>T	c.(718-720)TCC>TCT	p.S240S	TCF20_uc003bck.1_Silent_p.S240S|TCF20_uc003bnt.2_Silent_p.S240S	NM_005650	NP_005641	Q9UGU0	TCF20_HUMAN	transcription factor 20 isoform 1	240	Ser-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|transcription coactivator activity|zinc ion binding			ovary(4)|skin(1)	5						aggaggaggaggaAGCAGAAG	0.443		NaN											0	0	0	0.004672	0	3	45									
COL7A1	1294	broad.mit.edu	37	3	48623808	48623808	+	Missense_Mutation	SNP	C	C	G			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr3:48623808C>G	uc003ctz.2	-	26	3508	c.3507G>C	c.(3505-3507)TTG>TTC	p.L1169F		NM_000094	NP_000085	Q02388	CO7A1_HUMAN	alpha 1 type VII collagen precursor	1169	Nonhelical region (NC1).|VWFA 2.				cell adhesion|epidermis development	basement membrane|collagen type VII	protein binding|serine-type endopeptidase inhibitor activity			ovary(4)|breast(3)|skin(3)|central_nervous_system(1)	11				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		TGTCACCTCTCAAGGGTTCAT	0.587		NaN											0	0	0	0.01441	0	68	200									
MON1A	84315	broad.mit.edu	37	3	49947848	49947848	+	Silent	SNP	G	G	A	rs151189958		TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr3:49947848G>A	uc003cxz.2	-	4	1500	c.1374C>T	c.(1372-1374)GGC>GGT	p.G458G	MON1A_uc003cya.2_Silent_p.G296G|MON1A_uc003cyb.2_Silent_p.G296G	NM_032355	NP_115731	Q86VX9	MON1A_HUMAN	MON1 homolog A isoform a	361							protein binding			ovary(2)	2				BRCA - Breast invasive adenocarcinoma(193;4.62e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.00551)|Kidney(197;0.00621)		TCCAGGCCTCGCCCTCGCGAA	0.597		NaN											0	0	0	0.004482	0	8	43									
FLNB	2317	broad.mit.edu	37	3	58154337	58154337	+	Missense_Mutation	SNP	G	G	A	rs142229998		TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr3:58154337G>A	uc003djj.2	+	44	7534	c.7369G>A	c.(7369-7371)GGT>AGT	p.G2457S	FLNB_uc010hne.2_Missense_Mutation_p.G2488S|FLNB_uc003djk.2_Missense_Mutation_p.G2446S|FLNB_uc010hnf.2_Missense_Mutation_p.G2433S|FLNB_uc003djl.2_Missense_Mutation_p.G2277S|FLNB_uc003djm.2_Missense_Mutation_p.G2264S|uc003djn.2_Intron	NM_001457	NP_001448	O75369	FLNB_HUMAN	filamin B isoform 2	2457	Filamin 23.|Interaction with INPPL1.				actin cytoskeleton organization|cell differentiation|cytoskeletal anchoring at plasma membrane|signal transduction	cell cortex|integral to membrane|nucleus|sarcomere	actin binding			breast(8)|ovary(5)|lung(3)|skin(2)|central_nervous_system(1)	19				BRCA - Breast invasive adenocarcinoma(55;0.000335)|KIRC - Kidney renal clear cell carcinoma(284;0.0726)|Kidney(284;0.0898)		CGTCAAATACGGTGGGCCCAA	0.532		NaN											0	0	0	0.024245	0	13	48									
PDZRN3	23024	broad.mit.edu	37	3	73433185	73433185	+	Silent	SNP	G	G	A			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr3:73433185G>A	uc003dpl.1	-	10	2628	c.2532C>T	c.(2530-2532)GAC>GAT	p.D844D	PDZRN3_uc011bgh.1_Silent_p.D501D|PDZRN3_uc010hoe.1_Silent_p.D542D|PDZRN3_uc011bgf.1_Silent_p.D561D|PDZRN3_uc011bgg.1_Silent_p.D564D	NM_015009	NP_055824	Q9UPQ7	PZRN3_HUMAN	PDZ domain containing ring finger 3	844							ubiquitin-protein ligase activity|zinc ion binding			pancreas(2)|ovary(2)|skin(2)|large_intestine(1)	7		Prostate(10;0.114)|Lung NSC(201;0.187)|Lung SC(41;0.236)		BRCA - Breast invasive adenocarcinoma(55;0.00041)|Epithelial(33;0.0023)|LUSC - Lung squamous cell carcinoma(21;0.0048)|Lung(16;0.0105)|KIRC - Kidney renal clear cell carcinoma(39;0.111)|Kidney(39;0.134)		TCCGGCTCCCGTCGCTGGCTC	0.667		NaN											0	0	0	0.007291	0	28	38									
FXR1	8087	broad.mit.edu	37	3	180666136	180666136	+	Missense_Mutation	SNP	T	T	A			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr3:180666136T>A	uc003fkq.2	+	5	294	c.272T>A	c.(271-273)TTT>TAT	p.F91Y	FXR1_uc003fkp.2_Missense_Mutation_p.F6Y|FXR1_uc003fkr.2_Missense_Mutation_p.F91Y|FXR1_uc011bqj.1_Missense_Mutation_p.F5Y|FXR1_uc003fks.2_Missense_Mutation_p.F5Y|FXR1_uc011bqk.1_Missense_Mutation_p.F42Y|FXR1_uc011bql.1_Missense_Mutation_p.F78Y	NM_005087	NP_005078	P51114	FXR1_HUMAN	fragile X mental retardation-related protein 1	91					apoptosis|cell differentiation|muscle organ development	nucleolus|polysome				breast(1)	1	all_cancers(143;6.07e-14)|Ovarian(172;0.0212)		Epithelial(37;3.05e-35)|OV - Ovarian serous cystadenocarcinoma(80;2.4e-22)			GTCTTTTAGTTTTATGTCATT	0.318		NaN											0	0	0	0.021553	0	4	25									
CDS1	1040	broad.mit.edu	37	4	85553028	85553028	+	Missense_Mutation	SNP	A	A	G			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr4:85553028A>G	uc011ccv.1	+	6	1135	c.637A>G	c.(637-639)ATG>GTG	p.M213V	CDS1_uc010ike.1_Missense_Mutation_p.M17V	NM_001263	NP_001254	Q92903	CDS1_HUMAN	CDP-diacylglycerol synthase 1	213					signal transduction|visual perception	endoplasmic reticulum membrane|integral to membrane	diacylglycerol cholinephosphotransferase activity|phosphatidate cytidylyltransferase activity			large_intestine(2)|ovary(1)|breast(1)	4		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.00101)		GCAGTTTTATATGGTGTGTAT	0.338		NaN											0	0	0	0.006122	0	16	70									
PLK4	10733	broad.mit.edu	37	4	128807800	128807800	+	Missense_Mutation	SNP	C	C	A			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr4:128807800C>A	uc003ifo.2	+	5	1520	c.1275C>A	c.(1273-1275)AAC>AAA	p.N425K	PLK4_uc011cgs.1_Missense_Mutation_p.N393K|PLK4_uc011cgt.1_Missense_Mutation_p.N384K	NM_014264	NP_055079	O00444	PLK4_HUMAN	polo-like kinase 4	425					G2/M transition of mitotic cell cycle|positive regulation of centriole replication|trophoblast giant cell differentiation	centriole|cleavage furrow|cytosol|nucleolus	ATP binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity				0						CCACAGACAACAATGCCAACA	0.368		NaN											1	0	0.004672	0.004672	0.00485522	3	37									
TLR3	7098	broad.mit.edu	37	4	187005188	187005188	+	Missense_Mutation	SNP	C	C	G			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr4:187005188C>G	uc003iyq.2	+	4	2449	c.2348C>G	c.(2347-2349)TCT>TGT	p.S783C	TLR3_uc011ckz.1_Missense_Mutation_p.S506C|TLR3_uc003iyr.2_Missense_Mutation_p.S506C	NM_003265	NP_003256	O15455	TLR3_HUMAN	toll-like receptor 3 precursor	783	Cytoplasmic (Potential).|TIR.				activation of NF-kappaB-inducing kinase activity|cellular response to mechanical stimulus|defense response to bacterium|defense response to virus|detection of virus|hyperosmotic response|I-kappaB phosphorylation|inflammatory response|innate immune response|MyD88-independent toll-like receptor signaling pathway|negative regulation of osteoclast differentiation|positive regulation of chemokine production|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of interferon-beta production|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of toll-like receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|toll-like receptor 3 signaling pathway	endoplasmic reticulum membrane|endosome membrane|integral to plasma membrane	double-stranded RNA binding|transmembrane receptor activity			ovary(2)|prostate(1)|lung(1)|breast(1)	5		all_cancers(14;4.27e-52)|all_epithelial(14;7.69e-39)|all_lung(41;1.34e-13)|Lung NSC(41;3.58e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.0066)|Hepatocellular(41;0.00886)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|all_neural(102;0.243)		OV - Ovarian serous cystadenocarcinoma(60;1.47e-11)|BRCA - Breast invasive adenocarcinoma(30;1.14e-05)|GBM - Glioblastoma multiforme(59;0.000107)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.16)		GAAGACCAATCTCTCAAATTT	0.353		NaN											0	0	0	0.00499	0	17	61									
PAIP1	10605	broad.mit.edu	37	5	43556029	43556029	+	Missense_Mutation	SNP	A	A	T			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08			A	T	A	A		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr5:43556029A>T	uc003job.2	-	2	585	c.338T>A	c.(337-339)ATG>AAG	p.M113K	PAIP1_uc003joa.2_Missense_Mutation_p.M34K|PAIP1_uc010ivp.2_Missense_Mutation_p.M34K|PAIP1_uc010ivo.2_RNA|PAIP1_uc003joc.2_Missense_Mutation_p.M1K	NM_006451	NP_006442	Q9H074	PAIP1_HUMAN	poly(A) binding protein interacting protein 1	113					mRNA stabilization|nuclear-transcribed mRNA poly(A) tail shortening|translational initiation	cytosol	protein binding|RNA binding|translation activator activity			ovary(1)	1	Lung NSC(6;2.07e-05)					GGGCTTAGCCATTGCTGACTC	0.473		NaN											0	0	0	0.01441	0	62	60									
ATXN1	6310	broad.mit.edu	37	6	16327275	16327275	+	Missense_Mutation	SNP	G	G	A			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr6:16327275G>A	uc003nbt.2	-	8	2238	c.1267C>T	c.(1267-1269)CAC>TAC	p.H423Y	ATXN1_uc010jpi.2_Missense_Mutation_p.H423Y|ATXN1_uc010jpj.1_Intron	NM_000332	NP_000323	P54253	ATX1_HUMAN	ataxin 1	423					cell death|negative regulation of transcription, DNA-dependent|nuclear export|RNA processing	cytoplasm|nuclear inclusion body|nuclear matrix|nucleoplasm	identical protein binding|poly(G) RNA binding|poly(U) RNA binding|protein binding|protein C-terminus binding|protein self-association			skin(3)|central_nervous_system(1)	4	Breast(50;0.063)|Ovarian(93;0.0733)	all_hematologic(90;0.000682)|Ovarian(999;0.00973)				TAGGACCGGTGGCCAGGCTTC	0.622		NaN											0	0	0	0.01441	0	75	80									
TCTE1	202500	broad.mit.edu	37	6	44255546	44255546	+	Missense_Mutation	SNP	G	G	A			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr6:44255546G>A	uc003oxi.2	-	2	173	c.17C>T	c.(16-18)ACG>ATG	p.T6M	SPATS1_uc003oxg.2_Intron|TMEM151B_uc003oxf.2_Intron	NM_182539	NP_872345	Q5JU00	TCTE1_HUMAN	t-complex-associated testis expressed 1	6										ovary(2)|skin(2)	4	Hepatocellular(11;0.00908)|all_lung(25;0.0101)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)			TGCTGATGTCGTTACGGTATC	0.557		NaN											0	0	0	0.004482	0	6	24									
C6orf174	387104	broad.mit.edu	37	6	127796588	127796588	+	Silent	SNP	G	G	A			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr6:127796588G>A	uc003qbd.2	-	6	3448	c.2583C>T	c.(2581-2583)GAC>GAT	p.D861D	C6orf174_uc003qbc.2_Translation_Start_Site	NM_001012279	NP_001012279	Q5TF21	CF174_HUMAN	hypothetical protein LOC387104 precursor	861						integral to membrane				breast(3)|ovary(2)|skin(1)	6				GBM - Glioblastoma multiforme(226;0.026)|all cancers(137;0.161)		TGCGGCTGCCGTCGTCCTCCT	0.642		NaN											0	0	0	0.024334	0	25	47									
GRM1	2911	broad.mit.edu	37	6	146720574	146720574	+	Missense_Mutation	SNP	C	C	A			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr6:146720574C>A	uc010khw.1	+	8	2869	c.2399C>A	c.(2398-2400)GCT>GAT	p.A800D	GRM1_uc010khv.1_Missense_Mutation_p.A800D|GRM1_uc003qll.2_Missense_Mutation_p.A800D|GRM1_uc011edz.1_Missense_Mutation_p.A800D|GRM1_uc011eea.1_Missense_Mutation_p.A800D	NM_000838	NP_000829	Q13255	GRM1_HUMAN	glutamate receptor, metabotropic 1 isoform alpha	800	Helical; Name=6; (Potential).				synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			lung(8)|ovary(4)|central_nervous_system(3)|large_intestine(2)|breast(2)	19		Ovarian(120;0.0387)		OV - Ovarian serous cystadenocarcinoma(155;5.35e-08)|GBM - Glioblastoma multiforme(68;0.00762)	Acamprosate(DB00659)|L-Glutamic Acid(DB00142)	ATCTGGCTAGCTTTTGTGCCC	0.493		NaN											1	0	2.47511e-08	0.008361	2.67716e-08	26	69									
STXBP5	134957	broad.mit.edu	37	6	147527160	147527160	+	Silent	SNP	A	A	G			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr6:147527160A>G	uc003qlz.2	+	2	365	c.204A>G	c.(202-204)GTA>GTG	p.V68V	uc003qlt.1_5'Flank|uc003qlu.1_5'Flank|STXBP5_uc010khz.1_Silent_p.V68V|STXBP5_uc003qlx.2_RNA|STXBP5_uc003qly.2_5'UTR	NM_001127715	NP_001121187	Q5T5C0	STXB5_HUMAN	syntaxin binding protein 5 (tomosyn) isoform b	68	WD 1.				exocytosis|positive regulation of exocytosis|protein transport	cell junction|cytoplasmic vesicle membrane|nicotinic acetylcholine-gated receptor-channel complex|synaptic vesicle	syntaxin-1 binding				0		Ovarian(120;0.0164)		OV - Ovarian serous cystadenocarcinoma(155;1.77e-09)|GBM - Glioblastoma multiforme(68;0.0694)		TTGATCCTGTACAGAAGATCC	0.463		NaN											0	0	0	0.007835	0	35	25									
SYNE1	23345	broad.mit.edu	37	6	152675920	152675920	+	Silent	SNP	C	C	T	rs114858512	byFrequency	TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr6:152675920C>T	uc010kiw.2	-	67	11402	c.10800G>A	c.(10798-10800)TTG>TTA	p.L3600L	SYNE1_uc003qot.3_Silent_p.L3607L|SYNE1_uc003qou.3_Silent_p.L3600L|SYNE1_uc010kja.1_Silent_p.L305L	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	3600	Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		CCATTAGCCTCAATTTGTTCA	0.502		NaN								HNSCC(10;0.0054)			0	0	0	0.00499	0	17	60									
GPR31	2853	broad.mit.edu	37	6	167570440	167570440	+	Missense_Mutation	SNP	G	G	A			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr6:167570440G>A	uc011egq.1	-	1	880	c.880C>T	c.(880-882)CGG>TGG	p.R294W		NM_005299	NP_005290	O00270	GPR31_HUMAN	G protein-coupled receptor 31	294	Cytoplasmic (Potential).					integral to plasma membrane	G-protein coupled receptor activity				0		Breast(66;1.53e-05)|Ovarian(120;0.0606)		OV - Ovarian serous cystadenocarcinoma(33;4.81e-20)|BRCA - Breast invasive adenocarcinoma(81;4.45e-06)|GBM - Glioblastoma multiforme(31;0.00492)		AAGACCCTCCGATAGGAGCTC	0.597		NaN											0	0	0	0.004672	0	3	33									
ZNF716	441234	broad.mit.edu	37	7	57522240	57522240	+	Missense_Mutation	SNP	G	G	T			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr7:57522240G>T	uc011kdi.1	+	2	226	c.114G>T	c.(112-114)CAG>CAT	p.Q38H		NM_001159279	NP_001152751			zinc finger protein 716											ovary(2)	2						ATGCTCAGCAGAATTTATATA	0.373		NaN											1	0	0.000274275	0.004482	0.000293668	5	57									
SPDYE3	441272	broad.mit.edu	37	7	99917269	99917269	+	Silent	SNP	T	T	C			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr7:99917269T>C	uc003uug.1	+	4	537	c.297T>C	c.(295-297)TCT>TCC	p.S99S	uc011kjm.1_5'Flank	NM_001004351	NP_001004351	A6NKU9	SPDE3_HUMAN	speedy homolog E3	476											0						AGACCCACTCTCACATACCCT	0.532		NaN											0	0	0	0.01892	0	24	57									
ASB15	142685	broad.mit.edu	37	7	123269135	123269135	+	Missense_Mutation	SNP	G	G	A			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr7:123269135G>A	uc003vku.1	+	10	1379	c.1087G>A	c.(1087-1089)GTT>ATT	p.V363I	ASB15_uc003vkw.1_Missense_Mutation_p.V363I	NM_080928	NP_563616	Q8WXK1	ASB15_HUMAN	ankyrin repeat and SOCS box-containing 15	363	ANK 7.				intracellular signal transduction					skin(2)|lung(1)	3						TAATAATGACGTTCATTGCAC	0.438		NaN											0	0	0	0.021022	0	35	41									
ZNF212	7988	broad.mit.edu	37	7	148950982	148950982	+	Missense_Mutation	SNP	G	G	C			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr7:148950982G>C	uc003wfp.2	+	5	1060	c.964G>C	c.(964-966)GAG>CAG	p.E322Q		NM_012256	NP_036388	Q9UDV6	ZN212_HUMAN	zinc finger protein 212	322	C2H2-type 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|identical protein binding|zinc ion binding			ovary(1)	1	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00171)			TTCTGAGTGTGAGATCACCTT	0.567		NaN											0	0	0	0.009096	0	4	43									
MLL3	58508	broad.mit.edu	37	7	151962241	151962241	+	Missense_Mutation	SNP	G	G	C			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr7:151962241G>C	uc003wla.2	-	8	1285	c.1066C>G	c.(1066-1068)CAG>GAG	p.Q356E		NM_170606	NP_733751	Q8NEZ4	MLL3_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 3	356	PHD-type 1.|RING-type.				intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			large_intestine(27)|pancreas(13)|ovary(9)|central_nervous_system(8)|breast(3)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	63	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)		CAAAAGAACTGATCTAAGAGG	0.413		NaN	N		medulloblastoma								0	0	0	0.028581	0	12	271									
TEX15	56154	broad.mit.edu	37	8	30704505	30704505	+	Missense_Mutation	SNP	C	C	T			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr8:30704505C>T	uc003xil.2	-	1	2029	c.2029G>A	c.(2029-2031)GAA>AAA	p.E677K		NM_031271	NP_112561	Q9BXT5	TEX15_HUMAN	testis expressed 15	677										ovary(3)|upper_aerodigestive_tract(2)|skin(2)	7				KIRC - Kidney renal clear cell carcinoma(542;0.0918)|Kidney(114;0.111)		ATTTCAATTTCACTTTCCAAT	0.289		NaN											0	0	0	0.00308	0	6	19									
CYP11B2	1585	broad.mit.edu	37	8	143994845	143994845	+	Missense_Mutation	SNP	G	G	A			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr8:143994845G>A	uc003yxk.1	-	6	980	c.977C>T	c.(976-978)ACG>ATG	p.T326M		NM_000498	NP_000489	P19099	C11B2_HUMAN	cytochrome P450, family 11, subfamily B,	326					aldosterone biosynthetic process|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|potassium ion homeostasis|regulation of blood volume by renal aldosterone|sodium ion homeostasis|xenobiotic metabolic process		corticosterone 18-monooxygenase activity|electron carrier activity|steroid 11-beta-monooxygenase activity				0	all_cancers(97;5.56e-11)|all_epithelial(106;2.49e-08)|Lung NSC(106;0.000228)|all_lung(105;0.000633)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)				Candesartan(DB00796)|Metyrapone(DB01011)	CTCAAAGAGCGTCATCAGCAA	0.627		NaN							Familial_Hyperaldosteronism_type_I				0	0	0	0.01441	0	43	69									
RFX3	5991	broad.mit.edu	37	9	3277363	3277363	+	Missense_Mutation	SNP	C	C	T			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr9:3277363C>T	uc003zhr.2	-	9	1262	c.950G>A	c.(949-951)AGC>AAC	p.S317N	RFX3_uc010mhd.2_Missense_Mutation_p.S317N|RFX3_uc003zhs.1_Missense_Mutation_p.S317N|RFX3_uc003zht.1_Missense_Mutation_p.S317N|RFX3_uc010mhe.1_Missense_Mutation_p.S292N	NM_134428	NP_602304	P48380	RFX3_HUMAN	regulatory factor X3 isoform b	317					cell maturation|ciliary cell motility|cilium assembly|cilium movement involved in determination of left/right asymmetry|endocrine pancreas development|negative regulation of transcription, DNA-dependent|positive regulation of transcription from RNA polymerase II promoter|positive regulation of type B pancreatic cell development|regulation of insulin secretion	nuclear chromatin	protein binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding			ovary(2)|central_nervous_system(1)|pancreas(1)	4				GBM - Glioblastoma multiforme(50;0.00124)|Lung(2;0.0337)		ATGATGTTGGCTTTGGGCAAT	0.403		NaN											0	0	0	0.013726	0	32	67									
CEP110	11064	broad.mit.edu	37	9	123921142	123921142	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr9:123921142C>T	uc004bkx.1	+	29	4805	c.4774C>T	c.(4774-4776)CAG>TAG	p.Q1592*	CEP110_uc010mvo.1_Nonsense_Mutation_p.Q261*|CEP110_uc004blb.1_Nonsense_Mutation_p.Q261*|CEP110_uc010mvp.1_Intron	NM_007018	NP_008949	Q7Z7A1	CNTRL_HUMAN	centrosomal protein 110kDa	1592	Potential.				cell division|G2/M transition of mitotic cell cycle	centrosome|cytosol	protein binding				0						GGTGACAAGTCAGCAGCAGGA	0.463		NaN											0	0	0	0.01441	0	70	13									
ARPC5L	81873	broad.mit.edu	37	9	127637310	127637310	+	Silent	SNP	T	T	C			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr9:127637310T>C	uc004bpa.3	+	3	365	c.279T>C	c.(277-279)ATT>ATC	p.I93I	ARPC5L_uc011lzq.1_Silent_p.I41I	NM_030978	NP_112240	Q9BPX5	ARP5L_HUMAN	actin related protein 2/3 complex, subunit	93					regulation of actin filament polymerization	cytoplasm|cytoskeleton	actin binding				0						GCAGTGAGATTGAGCAGGCTG	0.502		NaN											0	0	0	0.00308	0	5	90									
TTC16	158248	broad.mit.edu	37	9	130485503	130485503	+	Missense_Mutation	SNP	C	C	T			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr9:130485503C>T	uc004brq.1	+	7	830	c.763C>T	c.(763-765)CGC>TGC	p.R255C	PTRH1_uc011mah.1_Intron|TTC16_uc011mai.1_Missense_Mutation_p.R242C|TTC16_uc004brr.1_Missense_Mutation_p.R200C|TTC16_uc010mxn.1_5'UTR	NM_144965	NP_659402	Q8NEE8	TTC16_HUMAN	tetratricopeptide repeat domain 16	255	TPR 4.						binding				0						CCAGCAGGCGCGCCAAGATGC	0.642		NaN											0	0	0	0.013114	0	45	6									
LRRC8A	56262	broad.mit.edu	37	9	131669702	131669702	+	Silent	SNP	C	C	T			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr9:131669702C>T	uc004bwl.3	+	3	513	c.259C>T	c.(259-261)CTG>TTG	p.L87L	LRRC8A_uc010myp.2_Silent_p.L87L|LRRC8A_uc010myq.2_Silent_p.L87L	NM_019594	NP_062540	Q8IWT6	LRC8A_HUMAN	leucine rich repeat containing 8 family, member	87					pre-B cell differentiation	integral to membrane					0						CTCCACCATTCTGCCGACCCC	0.617		NaN											0	0	0	0.01441	0	59	10									
LRRC8A	56262	broad.mit.edu	37	9	131670421	131670421	+	Silent	SNP	C	C	T			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr9:131670421C>T	uc004bwl.3	+	3	1232	c.978C>T	c.(976-978)ATC>ATT	p.I326I	LRRC8A_uc010myp.2_Silent_p.I326I|LRRC8A_uc010myq.2_Silent_p.I326I	NM_019594	NP_062540	Q8IWT6	LRC8A_HUMAN	leucine rich repeat containing 8 family, member	326	Helical; (Potential).				pre-B cell differentiation	integral to membrane					0						CCTTCTACATCAGCCTAGTCA	0.567		NaN											0	0	0	0.01441	0	71	11									
LRRC8A	56262	broad.mit.edu	37	9	131671081	131671081	+	Silent	SNP	C	C	G			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr9:131671081C>G	uc004bwl.3	+	3	1892	c.1638C>G	c.(1636-1638)CTC>CTG	p.L546L	LRRC8A_uc010myp.2_Silent_p.L546L|LRRC8A_uc010myq.2_Silent_p.L546L	NM_019594	NP_062540	Q8IWT6	LRC8A_HUMAN	leucine rich repeat containing 8 family, member	546	LRR 8.				pre-B cell differentiation	integral to membrane					0						TCAAACGCCTCAAGGTGCTGC	0.592		NaN											0	0	0	0.007291	0	28	4									
USP20	10868	broad.mit.edu	37	9	132620365	132620365	+	Missense_Mutation	SNP	G	G	A			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr9:132620365G>A	uc004bys.2	+	5	383	c.172G>A	c.(172-174)GCT>ACT	p.A58T	USP20_uc004byr.2_Missense_Mutation_p.A58T|USP20_uc004byt.1_Missense_Mutation_p.A58T	NM_001110303	NP_001103773	Q9Y2K6	UBP20_HUMAN	ubiquitin specific protease 20	58	UBP-type.				endocytosis|protein K48-linked deubiquitination|protein K63-linked deubiquitination|regulation of G-protein coupled receptor protein signaling pathway|ubiquitin-dependent protein catabolic process	perinuclear region of cytoplasm	cysteine-type endopeptidase activity|G-protein-coupled receptor binding|ubiquitin thiolesterase activity|zinc ion binding			lung(1)|breast(1)	2		Ovarian(14;0.00556)				AGAATCCTTTGCTGACCACAG	0.368		NaN											0	0	0	0.010771	0	37	51									
CXCR3	2833	broad.mit.edu	37	X	70836460	70836460	+	Missense_Mutation	SNP	G	G	A			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chrX:70836460G>A	uc004eaf.2	-	2	930	c.862C>T	c.(862-864)CGC>TGC	p.R288C	BCYRN1_uc011mpt.1_Intron|CXCR3_uc011mpx.1_Missense_Mutation_p.R335C	NM_001504	NP_001495	P49682	CXCR3_HUMAN	chemokine (C-X-C motif) receptor 3 isoform A	288	Extracellular (Potential).				cell adhesion|cellular component movement|chemotaxis|elevation of cytosolic calcium ion concentration	cytoplasm|integral to plasma membrane	C-X-C chemokine receptor activity			ovary(2)|central_nervous_system(1)	3	Renal(35;0.156)					CCACAGTTGCGGGCCAAAGCG	0.632		NaN											0	0	0	0.006122	0	16	16									
STAG2	10735	broad.mit.edu	37	X	123217380	123217380	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chrX:123217380C>T	uc004etz.3	+	28	3373	c.3034C>T	c.(3034-3036)CGA>TGA	p.R1012*	STAG2_uc004eua.2_Nonsense_Mutation_p.R1012*|STAG2_uc004eub.2_Nonsense_Mutation_p.R1012*|STAG2_uc004euc.2_Nonsense_Mutation_p.R1012*|STAG2_uc004eud.2_Nonsense_Mutation_p.R1012*|STAG2_uc004eue.2_Nonsense_Mutation_p.R1012*	NM_006603	NP_006594	Q8N3U4	STAG2_HUMAN	stromal antigen 2 isoform b	1012					cell division|meiosis|mitotic metaphase/anaphase transition|mitotic prometaphase|negative regulation of DNA endoreduplication|sister chromatid cohesion	chromatin|chromosome, centromeric region|nucleoplasm	protein binding			ovary(4)|skin(1)	5						TAAACTACTTCGACAAGACAA	0.343		NaN											0	0	0	0.01441	0	34	0									
GPC3	2719	broad.mit.edu	37	X	132670204	132670204	+	Missense_Mutation	SNP	A	A	C			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chrX:132670204A>C	uc004exe.1	-	8	1881	c.1691T>G	c.(1690-1692)CTT>CGT	p.L564R	GPC3_uc004exd.1_Missense_Mutation_p.L436R|GPC3_uc010nrn.1_Missense_Mutation_p.L587R|GPC3_uc011mvh.1_Missense_Mutation_p.L548R|GPC3_uc010nro.1_Missense_Mutation_p.L510R	NM_004484	NP_004475	P51654	GPC3_HUMAN	glypican 3 isoform 2 precursor	564						extracellular space|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding|peptidyl-dipeptidase inhibitor activity			lung(2)|prostate(1)|breast(1)|skin(1)	5	Acute lymphoblastic leukemia(192;0.000127)					GCTGGTGAGAAGCTTCAGCGG	0.562		NaN	T|D|Mis|N|F|S			Wilms tumour			Simpson-Golabi-Behmel_syndrome				0	0	0	0.01441	0	57	3									
TBL1Y	90665	broad.mit.edu	37	Y	6911149	6911149	+	Missense_Mutation	SNP	G	G	C			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chrY:6911149G>C	uc004frb.2	+	7	834	c.187G>C	c.(187-189)GAG>CAG	p.E63Q	TBL1Y_uc004frc.2_Missense_Mutation_p.E63Q|TBL1Y_uc004frd.2_Missense_Mutation_p.E63Q|TBL1Y_uc011nap.1_5'UTR	NM_033284	NP_150600	Q9BQ87	TBL1Y_HUMAN	transducin beta-like 1Y	63	F-box-like.				transcription, DNA-dependent						0						TGTAGAGGCTGAGATAAGCAT	0.527		NaN											0	0	0	0.010729	0	10	62									
SLAMF1	6504	broad.mit.edu	37	1	160589601	160589601	+	Frame_Shift_Del	DEL	T	T	-			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr1:160589601delT	uc001fwl.3	-	5	1175	c.829delA	c.(829-831)AGCfs	p.S277fs	SLAMF1_uc010pjk.1_Intron|SLAMF1_uc010pjl.1_Intron|SLAMF1_uc010pjm.1_Intron	NM_003037	NP_003028	Q13291	SLAF1_HUMAN	signaling lymphocytic activation molecule family	277	Cytoplasmic (Potential).|Ig-like V-type.				interspecies interaction between organisms|lymphocyte activation|positive regulation of cell proliferation	integral to membrane	antigen binding|transmembrane receptor activity			ovary(1)|breast(1)	2	all_cancers(52;4.94e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.0175)			ATCGTAAGGCTTTTTTTTTCC	0.433		NaN											NaN	NaN	NaN	NaN	NaN	8	178	---	---							
SPAG6	9576	broad.mit.edu	37	10	22690092	22690093	+	Frame_Shift_Ins	INS	-	-	A			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr10:22690092_22690093insA	uc001iri.2	+	9	1342_1343	c.1200_1201insA	c.(1198-1203)AGTAAAfs	p.S400fs	SPAG6_uc001irj.2_Frame_Shift_Ins_p.S400fs|SPAG6_uc010qct.1_Frame_Shift_Ins_p.S370fs|SPAG6_uc009xkh.2_Frame_Shift_Ins_p.S378fs	NM_012443	NP_036575	O75602	SPAG6_HUMAN	sperm associated antigen 6 isoform 1	400_401	ARM 8.				cell projection organization|spermatid development	axoneme|cilium|cytoplasm|flagellum|microtubule	binding			breast(1)	1						ATTTCTAGAGTAAAAAAGCCAT	0.327		NaN											NaN	NaN	NaN	NaN	NaN	16	49	---	---							
FBXW4	6468	broad.mit.edu	37	10	103454358	103454360	+	In_Frame_Del	DEL	CCT	CCT	-			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr10:103454358_103454360delCCT	uc001kto.2	-	1	384_386	c.38_40delAGG	c.(37-42)GAGGCG>GCG	p.E13del		NM_022039	NP_071322	P57775	FBXW4_HUMAN	F-box and WD repeat domain containing 4	13					ubiquitin-dependent protein catabolic process|Wnt receptor signaling pathway	ubiquitin ligase complex				skin(1)	1		Colorectal(252;0.123)		Epithelial(162;4.35e-08)|all cancers(201;1.92e-06)		TCCCGAGCCGcctcctcctcctc	0.675		NaN											NaN	NaN	NaN	NaN	NaN	2	4	---	---							
MARK2	2011	broad.mit.edu	37	11	63668273	63668276	+	Frame_Shift_Del	DEL	ATGA	ATGA	-			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr11:63668273_63668276delATGA	uc001nxw.2	+	10	1489_1492	c.910_913delATGA	c.(910-915)ATGAATfs	p.M304fs	MARK2_uc001nxx.2_Frame_Shift_Del_p.M304fs|MARK2_uc001nxy.2_Frame_Shift_Del_p.M304fs|MARK2_uc001nxv.3_Frame_Shift_Del_p.M304fs|MARK2_uc001nxz.3_Frame_Shift_Del_p.M271fs|MARK2_uc009yoy.2_Frame_Shift_Del_p.M271fs	NM_001039469	NP_001034558	Q7KZI7	MARK2_HUMAN	MAP/microtubule affinity-regulating kinase 2	304_305					cell differentiation|establishment or maintenance of epithelial cell apical/basal polarity|intracellular protein kinase cascade|multicellular organismal development|response to oxidative stress	plasma membrane	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			stomach(1)|ovary(1)|lung(1)	3						AGATCGATGGATGAATGTGGGTCA	0.564		NaN											NaN	NaN	NaN	NaN	NaN	95	144	---	---							
FAM155A	728215	broad.mit.edu	37	13	108518687	108518689	+	In_Frame_Del	DEL	CTG	CTG	-			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr13:108518687_108518689delCTG	uc001vql.2	-	1	772_774	c.256_258delCAG	c.(256-258)CAGdel	p.Q86del		NM_001080396	NP_001073865	B1AL88	F155A_HUMAN	family with sequence similarity 155, member A	86	Poly-Gln.					integral to membrane	binding			skin(1)	1						gccgctgcctctgctgctgctgc	0.404		NaN											NaN	NaN	NaN	NaN	NaN	7	31	---	---							
H1FOO	132243	broad.mit.edu	37	3	129268107	129268108	+	Frame_Shift_Ins	INS	-	-	A	rs150160917	by1000genomes	TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr3:129268107_129268108insA	uc003emu.2	+	3	647_648	c.642_643insA	c.(640-645)GCTAGGfs	p.A214fs	H1FOO_uc003emv.2_Frame_Shift_Ins_p.A75fs	NM_153833	NP_722575	Q8IZA3	H1FOO_HUMAN	H1 histone family, member O, oocyte-specific	214_215					meiosis|nucleosome assembly	cytoplasm|nucleosome	DNA binding			skin(1)	1						CGGGAGAGGCTAGGAAGGTGCC	0.653		NaN											NaN	NaN	NaN	NaN	NaN	3	6	---	---							
PILRB	29990	broad.mit.edu	37	7	99956513	99956514	+	Frame_Shift_Ins	INS	-	-	T			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr7:99956513_99956514insT	uc003uuk.2	+	16	2761_2762	c.265_266insT	c.(265-267)ATTfs	p.I89fs	PILRB_uc003uul.2_Intron|PILRB_uc003uum.1_RNA|PILRB_uc003uun.2_Frame_Shift_Ins_p.I89fs	NM_013440	NP_038468	Q9UKJ0	PILRB_HUMAN	paired immunoglobulin-like type 2 receptor beta	89	Extracellular (Potential).|Ig-like V-type.				activation of transmembrane receptor protein tyrosine kinase activity	integral to plasma membrane	protein binding|receptor activity				0	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					GCCGCCTTCCATTCACAAGGAT	0.55		NaN											NaN	NaN	NaN	NaN	NaN	53	105	---	---