Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	isArtifactMode	oxoGCut	pox	pox_cutoff	qox	t_alt_count	t_ref_count	validation_alt_allele	validation_tumor_sample							
VWA1	64856	broad.mit.edu	37	1	1372365	1372365	+	Silent	SNP	C	C	T			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr1:1372365C>T	uc001afs.2	+	2	352	c.132C>T	c.(130-132)AGC>AGT	p.S44S	VWA1_uc001afr.2_Intron	NM_022834	NP_073745	Q6PCB0	VWA1_HUMAN	von Willebrand factor A domain containing 1	44	VWFA.					basement membrane					0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;1.79e-36)|OV - Ovarian serous cystadenocarcinoma(86;3.94e-22)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.00461)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.145)		GCTCAGCCAGCGTCTCTCACT	0.672		NaN											0	0	0	0.279185	0	43	42									
VPS13D	55187	broad.mit.edu	37	1	12336628	12336628	+	Nonsense_Mutation	SNP	G	G	T			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr1:12336628G>T	uc001atv.2	+	19	3124	c.2983G>T	c.(2983-2985)GAA>TAA	p.E995*	VPS13D_uc001atw.2_Nonsense_Mutation_p.E995*|VPS13D_uc001atx.2_Nonsense_Mutation_p.E183*	NM_015378	NP_056193	Q5THJ4	VP13D_HUMAN	vacuolar protein sorting 13D isoform 1	995					protein localization					ovary(4)|pancreas(1)	5	Ovarian(185;0.249)	Lung NSC(185;4.08e-05)|all_lung(284;4.55e-05)|Renal(390;0.000147)|Colorectal(325;0.00058)|Breast(348;0.00093)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0327)|Colorectal(212;4.63e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000289)|COAD - Colon adenocarcinoma(227;0.000801)|Kidney(185;0.00216)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(313;0.012)|READ - Rectum adenocarcinoma(331;0.0476)|Lung(427;0.209)		TTATGATGCTGAAGTCTCCCT	0.453		NaN									OREG0013110	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	1	0	2.20344e-50	0.139131	2.47488e-50	107	69									
PRAMEF2	65122	broad.mit.edu	37	1	12918913	12918913	+	Silent	SNP	C	C	T			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr1:12918913C>T	uc001aum.1	+	2	136	c.49C>T	c.(49-51)CTG>TTG	p.L17L		NM_023014	NP_075390	O60811	PRAM2_HUMAN	PRAME family member 2	17											0	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.00224)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;2.4e-06)|Kidney(185;4.89e-05)|COAD - Colon adenocarcinoma(227;0.000152)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		GGGGCAGAGCCTGCTGAGAGA	0.562		NaN											0	0	0	0.139131	0	106	77									
ZMYM4	9202	broad.mit.edu	37	1	35853067	35853067	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr1:35853067C>T	uc001byt.2	+	13	2205	c.2125C>T	c.(2125-2127)CAG>TAG	p.Q709*	ZMYM4_uc009vuu.2_Nonsense_Mutation_p.Q677*|ZMYM4_uc001byu.2_Nonsense_Mutation_p.Q385*|ZMYM4_uc009vuv.2_Nonsense_Mutation_p.Q448*	NM_005095	NP_005086	Q5VZL5	ZMYM4_HUMAN	zinc finger protein 262	709	MYM-type 7.				multicellular organismal development		DNA binding|zinc ion binding			large_intestine(2)|ovary(1)|kidney(1)|skin(1)	5		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				CAAAATGTTTCAGTTCTGTGG	0.294		NaN											0	0	0	0.183431	0	34	70									
PGM1	5236	broad.mit.edu	37	1	64114205	64114205	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr1:64114205G>A	uc001dbh.2	+	8	1375	c.1162G>A	c.(1162-1164)GAG>AAG	p.E388K	PGM1_uc010ooy.1_Missense_Mutation_p.E191K|PGM1_uc010ooz.1_Missense_Mutation_p.E406K	NM_002633	NP_002624	P36871	PGM1_HUMAN	phosphoglucomutase 1	388					cellular calcium ion homeostasis|galactose catabolic process|glucose 1-phosphate metabolic process|glycogen biosynthetic process|glycogen catabolic process	cytosol	magnesium ion binding|phosphoglucomutase activity			ovary(2)|kidney(1)	3						CCACATCCGTGAGAAAGATGG	0.478		NaN											0	0	0	0.069234	0	10	24									
IL23R	149233	broad.mit.edu	37	1	67672625	67672625	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr1:67672625G>A	uc001ddo.2	+	6	770	c.685G>A	c.(685-687)GAG>AAG	p.E229K	IL23R_uc009waz.2_Missense_Mutation_p.E26K|IL23R_uc001ddp.2_RNA|IL23R_uc010opi.1_RNA|IL23R_uc010opj.1_5'UTR|IL23R_uc010opk.1_Missense_Mutation_p.E186K|IL23R_uc010opl.1_Intron|IL23R_uc010opm.1_RNA|IL23R_uc001ddq.2_5'UTR|IL23R_uc010opn.1_Missense_Mutation_p.E74K|IL23R_uc001ddr.2_RNA|IL23R_uc010opo.1_Missense_Mutation_p.E88K|IL23R_uc010opp.1_Intron|IL23R_uc010opq.1_Missense_Mutation_p.E88K|IL23R_uc010opr.1_RNA|IL23R_uc010ops.1_Missense_Mutation_p.E26K|IL23R_uc010opt.1_5'UTR|IL23R_uc010opu.1_Intron|IL23R_uc010opv.1_Intron|IL23R_uc010opw.1_5'UTR|IL23R_uc010opx.1_Intron|IL23R_uc010opy.1_Missense_Mutation_p.E26K|IL23R_uc010opz.1_Intron|IL23R_uc010oqa.1_Intron|IL23R_uc010oqb.1_Missense_Mutation_p.E88K|IL23R_uc010oqc.1_5'UTR|IL23R_uc010oqd.1_Intron|IL23R_uc010oqe.1_5'UTR|IL23R_uc010oqf.1_5'UTR|IL23R_uc010oqg.1_5'UTR|IL23R_uc010oqh.1_Intron|IL23R_uc001dds.2_5'Flank|IL23R_uc001ddt.2_5'Flank	NM_144701	NP_653302	Q5VWK5	IL23R_HUMAN	interleukin 23 receptor precursor	229	Extracellular (Potential).|Fibronectin type-III 2.				inflammatory response|negative regulation of interleukin-10 production|positive regulation of defense response to virus by host|positive regulation of interferon-gamma production|positive regulation of interleukin-12 production|positive regulation of memory T cell differentiation|positive regulation of T cell mediated cytotoxicity|positive regulation of T-helper 1 type immune response|positive regulation of T-helper 17 cell lineage commitment|positive regulation of T-helper 17 type immune response|response to interferon-gamma|response to lipopolysaccharide	interleukin-23 receptor complex	receptor activity				0						TTCCAGGGCTGAGACTATAAA	0.373		NaN											0	0	0	0.160694	0	18	8									
FPGT	8790	broad.mit.edu	37	1	74670283	74670283	+	Missense_Mutation	SNP	C	C	A			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr1:74670283C>A	uc001dgb.1	+	4	589	c.552C>A	c.(550-552)GAC>GAA	p.D184E	TNNI3K_uc001dgc.1_Intron|TNNI3K_uc001dgd.2_Intron|TNNI3K_uc001dge.1_Intron|FPGT_uc010oqt.1_Intron|FPGT_uc010oqu.1_Intron|FPGT_uc010oqv.1_Intron	NM_003838	NP_003829	O14772	FPGT_HUMAN	fucose-1-phosphate guanyltransferase	184					fucose metabolic process	cytoplasm	fucose-1-phosphate guanylyltransferase activity|GTP binding			skin(1)	1						TTAGGTTTGACAAACCTGGCT	0.348		NaN											1	0	1.06961e-07	0.27861	1.11268e-07	8	59									
RPAP2	79871	broad.mit.edu	37	1	92789860	92789860	+	Silent	SNP	G	G	C			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr1:92789860G>C	uc001dot.2	+	8	1492	c.1383G>C	c.(1381-1383)CTG>CTC	p.L461L	RPAP2_uc009wdh.2_RNA	NM_024813	NP_079089	Q8IXW5	RPAP2_HUMAN	RNA polymerase II associated protein 2	461						integral to membrane|nucleus	metal ion binding|phosphoprotein phosphatase activity			ovary(1)	1		all_lung(203;0.0565)|Lung NSC(277;0.152)|Glioma(108;0.222)		all cancers(265;0.00647)|GBM - Glioblastoma multiforme(16;0.0234)|Epithelial(280;0.115)		AGTTAAATCTGAGGATCAGGG	0.403		NaN											0	0	0	0.189662	0	20	58									
CRTC2	200186	broad.mit.edu	37	1	153930832	153930832	+	Missense_Mutation	SNP	C	C	A			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr1:153930832C>A	uc010ped.1	-	1	212	c.142G>T	c.(142-144)GGC>TGC	p.G48C		NM_181715	NP_859066	Q53ET0	CRTC2_HUMAN	CREB regulated transcription coactivator 2	48					interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	protein binding			ovary(2)	2	all_lung(78;3.05e-32)|Lung NSC(65;3.74e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)			CGGGTGGAGCCGATGTCCATC	0.572		NaN											1	0	4.7546e-09	0.146539	5.0477e-09	14	20									
NUF2	83540	broad.mit.edu	37	1	163317648	163317648	+	Silent	SNP	G	G	A			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr1:163317648G>A	uc001gcq.1	+	12	1344	c.1044G>A	c.(1042-1044)AAG>AAA	p.K348K	NUF2_uc001gcr.1_Silent_p.K348K|NUF2_uc009wvc.1_Silent_p.K301K	NM_145697	NP_663735	Q9BZD4	NUF2_HUMAN	NUF2, NDC80 kinetochore complex component	348	Interaction with the N-terminus of NDC80.				cell division|chromosome segregation|mitotic prometaphase	condensed chromosome kinetochore|cytosol|Ndc80 complex|nucleus	protein binding			ovary(3)|skin(1)	4	all_hematologic(923;0.101)					TGATTGTGAAGAAGGAAAAAC	0.353		NaN											0	0	0	0.058154	0	9	45									
POU2F1	5451	broad.mit.edu	37	1	167365587	167365587	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr1:167365587G>A	uc001gec.2	+	11	1145	c.983G>A	c.(982-984)CGA>CAA	p.R328Q	POU2F1_uc010plg.1_RNA|POU2F1_uc001ged.2_Missense_Mutation_p.R326Q|POU2F1_uc001gee.2_Missense_Mutation_p.R328Q|POU2F1_uc010plh.1_Missense_Mutation_p.R265Q|POU2F1_uc001gef.2_Missense_Mutation_p.R340Q|POU2F1_uc001geg.2_Missense_Mutation_p.R226Q|POU2F1_uc009wvg.1_5'Flank	NM_002697	NP_002688	P14859	PO2F1_HUMAN	POU class 2 homeobox 1	328	POU-specific.				negative regulation of transcription, DNA-dependent|transcription from RNA polymerase III promoter	nucleoplasm	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(2)|skin(2)|breast(1)	5						ACCATCTCTCGATTTGAAGCC	0.428		NaN											0	0	0	0.139131	0	124	13									
CAMSAP1L1	23271	broad.mit.edu	37	1	200819069	200819069	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr1:200819069G>A	uc001gvl.2	+	12	3475	c.3205G>A	c.(3205-3207)GAA>AAA	p.E1069K	CAMSAP1L1_uc001gvk.2_Missense_Mutation_p.E1058K|CAMSAP1L1_uc001gvm.2_Missense_Mutation_p.E1042K	NM_203459	NP_982284	Q08AD1	CAMP2_HUMAN	calmodulin regulated spectrin-associated protein	1069						cytoplasm|microtubule	protein binding			ovary(2)|large_intestine(1)|pancreas(1)	4						ACATAATCCAGAAGAAAAGGA	0.413		NaN											0	0	0	0.279207	0	25	67									
ACTA1	58	broad.mit.edu	37	1	229567907	229567907	+	Missense_Mutation	SNP	G	G	C			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr1:229567907G>C	uc001htm.2	-	5	747	c.642C>G	c.(640-642)ATC>ATG	p.I214M		NM_001100	NP_001091	P68133	ACTS_HUMAN	actin, alpha 1, skeletal muscle	214					muscle filament sliding|skeletal muscle fiber development|skeletal muscle thin filament assembly	actin filament|cytosol|stress fiber|striated muscle thin filament	ADP binding|ATP binding|myosin binding|structural constituent of cytoskeleton				0	Breast(184;0.0858)|Ovarian(103;0.103)	Prostate(94;0.167)			Dornase Alfa(DB00003)	GCTTCTCCTTGATGTCGCGCA	0.517		NaN											0	0	0	0.160694	0	16	12									
ARID4B	51742	broad.mit.edu	37	1	235403707	235403707	+	Missense_Mutation	SNP	A	A	G			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr1:235403707A>G	uc001hwq.2	-	8	1004	c.506T>C	c.(505-507)ATT>ACT	p.I169T	ARID4B_uc001hwr.2_Missense_Mutation_p.I169T|ARID4B_uc001hws.3_Missense_Mutation_p.I169T|ARID4B_uc001hwu.1_Missense_Mutation_p.I169T|ARID4B_uc001hwt.3_5'UTR	NM_016374	NP_057458	Q4LE39	ARI4B_HUMAN	AT rich interactive domain 4B isoform 1	169					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|protein binding			ovary(2)|lung(1)	3	Ovarian(103;0.0473)|Breast(184;0.23)	all_cancers(173;0.000782)|Prostate(94;0.0132)|all_epithelial(177;0.0808)|Lung SC(1967;0.24)	OV - Ovarian serous cystadenocarcinoma(106;2.86e-05)			TAGCTCATCAATCTGTTTCCT	0.373		NaN											0	0	0	0.225048	0	38	4									
OR2T11	127077	broad.mit.edu	37	1	248789671	248789671	+	Missense_Mutation	SNP	G	G	C			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr1:248789671G>C	uc001ier.1	-	1	759	c.759C>G	c.(757-759)TTC>TTG	p.F253L		NM_001001964	NP_001001964	Q8NH01	O2T11_HUMAN	olfactory receptor, family 2, subfamily T,	253	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			lung(1)	1	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			CGTATGTGTAGAAGGCAGCCC	0.522		NaN											0	0	0	0.09319	0	13	51									
SH3BP5L	80851	broad.mit.edu	37	1	249119080	249119080	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr1:249119080G>A	uc001iew.1	-	2	607	c.55C>T	c.(55-57)CGG>TGG	p.R19W	SH3BP5L_uc001iev.1_5'UTR|hsa-mir-3124|MI0014140_5'Flank	NM_030645	NP_085148	Q7L8J4	3BP5L_HUMAN	SH3-binding domain protein 5-like	19											0	all_cancers(71;3.33e-06)|all_epithelial(71;2.41e-06)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.0458)|Lung NSC(105;0.0494)|Melanoma(84;0.199)	all_cancers(173;0.19)	OV - Ovarian serous cystadenocarcinoma(106;0.00805)			ACTTCAGGCCGCAGCTCCCCC	0.607		NaN											0	0	0	0.139131	0	91	39									
GALNTL4	374378	broad.mit.edu	37	11	11362441	11362441	+	Silent	SNP	G	G	A			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr11:11362441G>A	uc001mjo.2	-	7	1624	c.1203C>T	c.(1201-1203)AAC>AAT	p.N401N		NM_198516	NP_940918	Q6P9A2	GLTL4_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide	401	Lumenal (Potential).					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding				0				all cancers(16;3.67e-05)|Epithelial(150;0.000184)		CCCTGAGAGCGTTCCTGCGGA	0.582		NaN											0	0	0	0.139131	0	103	105									
PIK3C2A	5286	broad.mit.edu	37	11	17113773	17113773	+	Missense_Mutation	SNP	G	G	C			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr11:17113773G>C	uc001mmq.3	-	28	4568	c.4502C>G	c.(4501-4503)GCC>GGC	p.A1501G	PIK3C2A_uc009ygu.1_Missense_Mutation_p.A104G|PIK3C2A_uc010rcw.1_Missense_Mutation_p.A1121G|PIK3C2A_uc001mmr.3_Intron	NM_002645	NP_002636	O00443	P3C2A_HUMAN	phosphoinositide-3-kinase, class 2 alpha	1501	PX.				cell communication|phosphatidylinositol biosynthetic process|phosphatidylinositol-mediated signaling	clathrin-coated vesicle|Golgi apparatus|nucleus|phosphatidylinositol 3-kinase complex|plasma membrane	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity			lung(4)|central_nervous_system(4)|stomach(1)|ovary(1)	10					Phosphatidylserine(DB00144)	TTTCCTTTTGGCTGCTACATC	0.323		NaN											0	0	0	0.134883	0	32	39									
KCNJ11	3767	broad.mit.edu	37	11	17408909	17408909	+	Missense_Mutation	SNP	C	C	T			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr11:17408909C>T	uc001mna.2	-	1	1298	c.730G>A	c.(730-732)GTG>ATG	p.V244M	KCNJ11_uc001mnb.3_Missense_Mutation_p.V157M	NM_000525	NP_000516	B4DWI4	B4DWI4_HUMAN	potassium inwardly-rectifying channel J11	244						integral to membrane	ATP-activated inward rectifier potassium channel activity			ovary(1)	1				READ - Rectum adenocarcinoma(2;0.0276)|Colorectal(2;0.0633)		TTGCCACCCACGCCGTTCTCC	0.627		NaN									OREG0020810	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.225048	0	39	46									
ACCS	84680	broad.mit.edu	37	11	44089204	44089204	+	Silent	SNP	C	C	T			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr11:44089204C>T	uc009yks.1	+	2	171	c.27C>T	c.(25-27)TTC>TTT	p.F9F	ACCS_uc010rfm.1_5'UTR|ACCS_uc010rfn.1_Silent_p.F9F|ACCS_uc001mxx.2_Silent_p.F9F	NM_001127219	NP_001120691	Q96QU6	1A1L1_HUMAN	1-aminocyclopropane-1-carboxylate synthase	9							1-aminocyclopropane-1-carboxylate synthase activity|protein homodimerization activity|pyridoxal phosphate binding|transferase activity, transferring nitrogenous groups			breast(2)|ovary(1)|lung(1)	4						AAAAGGACTTCAGGGCTCCCA	0.537		NaN											0	0	0	0.225048	0	37	34									
FOLH1	2346	broad.mit.edu	37	11	49227726	49227726	+	Splice_Site	SNP	T	T	G			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr11:49227726T>G	uc001ngy.2	-	2	380	c.119_splice	c.e2-1	p.G40_splice	FOLH1_uc001ngz.2_Splice_Site_p.G40_splice|FOLH1_uc009yly.2_Splice_Site_p.G25_splice|FOLH1_uc009ylz.2_Splice_Site_p.G25_splice|FOLH1_uc009yma.2_Splice_Site|FOLH1_uc001nha.2_Splice_Site_p.G25_splice	NM_004476	NP_004467	Q04609	FOLH1_HUMAN	folate hydrolase 1 isoform 1						proteolysis	cytoplasm|integral to plasma membrane|membrane fraction|nucleus	carboxypeptidase activity|dipeptidase activity|metal ion binding|metallopeptidase activity			large_intestine(1)|ovary(1)|skin(1)	3					Capromab(DB00089)|L-Glutamic Acid(DB00142)	TAAACCACCCTGAAAAATACA	0.299		NaN											0	0	0	0.069234	0	10	77									
VWCE	220001	broad.mit.edu	37	11	61036487	61036487	+	Missense_Mutation	SNP	C	C	G			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr11:61036487C>G	uc001nra.2	-	15	2068	c.1789G>C	c.(1789-1791)GAT>CAT	p.D597H	VWCE_uc001nrb.2_RNA	NM_152718	NP_689931	Q96DN2	VWCE_HUMAN	von Willebrand factor C and EGF domains	597	VWFC 4.					extracellular region	calcium ion binding			ovary(1)	1						ACCGAGCCATCTGCCTGGAGG	0.612		NaN											0	0	0	0.09319	0	12	12									
GRIA4	2893	broad.mit.edu	37	11	105797472	105797472	+	Missense_Mutation	SNP	T	T	C			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr11:105797472T>C	uc001pix.2	+	13	2299	c.1853T>C	c.(1852-1854)CTC>CCC	p.L618P	GRIA4_uc001piw.2_Missense_Mutation_p.L618P	NM_000829	NP_000820	P48058	GRIA4_HUMAN	glutamate receptor, ionotrophic, AMPA 4 isoform	618	Cytoplasmic (Potential).				glutamate signaling pathway|synaptic transmission	cell junction|endocytic vesicle membrane|integral to membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity			ovary(3)|skin(3)|lung(1)|central_nervous_system(1)	8		Melanoma(852;0.000902)|Acute lymphoblastic leukemia(157;0.000994)|all_hematologic(158;0.0017)|Breast(348;0.0323)		BRCA - Breast invasive adenocarcinoma(274;0.000147)|Epithelial(105;0.0291)|all cancers(92;0.0899)	L-Glutamic Acid(DB00142)	tttagaTCCCTCTCAGGTCGA	0.259		NaN											0	0	0	0.294199	0	21	75									
TECTA	7007	broad.mit.edu	37	11	120998486	120998486	+	Silent	SNP	C	C	T			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr11:120998486C>T	uc010rzo.1	+	8	1800	c.1800C>T	c.(1798-1800)TTC>TTT	p.F600F		NM_005422	NP_005413	O75443	TECTA_HUMAN	tectorin alpha precursor	600	TIL 1.				cell-matrix adhesion|sensory perception of sound	anchored to membrane|plasma membrane|proteinaceous extracellular matrix				breast(6)|ovary(2)|skin(2)	10	all_hematologic(175;0.208)	Breast(109;0.000766)|Medulloblastoma(222;0.0427)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;8.04e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.166)		GCCCGAGCTTCAGCCACTACT	0.622		NaN											0	0	0	0.301197	0	41	43									
NEUROD4	58158	broad.mit.edu	37	12	55420322	55420322	+	Missense_Mutation	SNP	G	G	C			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr12:55420322G>C	uc001sgp.3	+	2	477	c.99G>C	c.(97-99)GAG>GAC	p.E33D		NM_021191	NP_067014	Q9HD90	NDF4_HUMAN	neurogenic differentiation 4	33					amacrine cell differentiation|positive regulation of cell differentiation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(3)|skin(1)	4						AGGTGAAGGAGGAAGAGAGCA	0.393		NaN											0	0	0	0.163468	0	32	11									
MTERFD3	80298	broad.mit.edu	37	12	107372070	107372070	+	Silent	SNP	A	A	G			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr12:107372070A>G	uc001tme.1	-	2	2242	c.423T>C	c.(421-423)TTT>TTC	p.F141F	MTERFD3_uc001tmf.1_Silent_p.F141F|MTERFD3_uc001tmg.1_Silent_p.F141F|MTERFD3_uc001tmh.1_Silent_p.F141F	NM_025198	NP_079474	Q49AM1	MTER3_HUMAN	transcription termination factor-like protein	141					regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrial nucleoid	transcription regulatory region DNA binding				0						CTTTAATAGTAAAGAAAGATT	0.398		NaN											0	0	0	0.11911	0	15	77									
DCLK1	9201	broad.mit.edu	37	13	36396889	36396889	+	Missense_Mutation	SNP	C	C	T			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr13:36396889C>T	uc001uvf.2	-	11	1764	c.1531G>A	c.(1531-1533)GAT>AAT	p.D511N	DCLK1_uc001uve.3_Missense_Mutation_p.D204N|DCLK1_uc010teh.1_Missense_Mutation_p.D204N|DCLK1_uc010abk.2_Intron	NM_004734	NP_004725	O15075	DCLK1_HUMAN	doublecortin-like kinase 1	511	Protein kinase.	Proton acceptor (By similarity).			cell differentiation|central nervous system development|endosome transport|intracellular signal transduction|response to virus	integral to plasma membrane	ATP binding|protein serine/threonine kinase activity|receptor signaling protein activity			stomach(6)|ovary(2)|skin(1)	9		Breast(139;0.0147)|Lung SC(185;0.0685)|Prostate(109;0.122)	KIRC - Kidney renal clear cell carcinoma(5;0.119)|Kidney(79;0.169)	all cancers(112;1.72e-06)|Epithelial(112;4.24e-05)|BRCA - Breast invasive adenocarcinoma(63;0.00159)|OV - Ovarian serous cystadenocarcinoma(117;0.0158)|GBM - Glioblastoma multiforme(144;0.0638)		GGCTTGATATCACGGTGGACG	0.458		NaN											0	0	0	0.214465	0	36	40									
ZNF828	283489	broad.mit.edu	37	13	115089918	115089918	+	Missense_Mutation	SNP	C	C	T			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr13:115089918C>T	uc010ahb.2	+	3	930	c.601C>T	c.(601-603)CCT>TCT	p.P201S	ZNF828_uc001vuv.2_Missense_Mutation_p.P201S|ZNF828_uc010tko.1_Missense_Mutation_p.P201S	NM_001164144	NP_001157616	Q96JM3	ZN828_HUMAN	zinc finger protein 828	201	Pro-rich.				attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation|protein localization to kinetochore|protein localization to microtubule|sister chromatid biorientation	condensed chromosome kinetochore|cytoplasm|nucleus|spindle	nucleic acid binding|protein binding|zinc ion binding			ovary(2)	2	Lung NSC(43;0.00299)|all_neural(89;0.0337)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_epithelial(44;0.122)|all_lung(25;0.123)	BRCA - Breast invasive adenocarcinoma(86;0.104)	OV - Ovarian serous cystadenocarcinoma(48;0.193)|Epithelial(10;0.197)		GAAACTTGCCCCTGTTCCTTC	0.488		NaN											0	0	0	0.139131	0	94	112									
RABGGTA	5875	broad.mit.edu	37	14	24739609	24739609	+	Missense_Mutation	SNP	C	C	T			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr14:24739609C>T	uc001wof.2	-	3	592	c.170G>A	c.(169-171)GGA>GAA	p.G57E	RABGGTA_uc001woe.2_5'Flank|RABGGTA_uc001wog.2_Missense_Mutation_p.G57E|RABGGTA_uc001woh.2_RNA|RABGGTA_uc001woi.2_RNA	NM_004581	NP_004572	Q92696	PGTA_HUMAN	Rab geranylgeranyltransferase alpha	57	PFTA 1.				visual perception		Rab geranylgeranyltransferase activity|zinc ion binding				0				GBM - Glioblastoma multiforme(265;0.0184)		AGGGTTGGCTCCCAGAATCTG	0.537		NaN											0	0	0	0.160694	0	18	1									
RABGGTA	5875	broad.mit.edu	37	14	24739631	24739631	+	Missense_Mutation	SNP	C	C	T			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr14:24739631C>T	uc001wof.2	-	3	570	c.148G>A	c.(148-150)GAA>AAA	p.E50K	RABGGTA_uc001woe.2_5'Flank|RABGGTA_uc001wog.2_Missense_Mutation_p.E50K|RABGGTA_uc001woh.2_RNA|RABGGTA_uc001woi.2_RNA	NM_004581	NP_004572	Q92696	PGTA_HUMAN	Rab geranylgeranyltransferase alpha	50	PFTA 1.				visual perception		Rab geranylgeranyltransferase activity|zinc ion binding				0				GBM - Glioblastoma multiforme(265;0.0184)		CTTGTCAGTTCCAGCACGGAC	0.522		NaN											0	0	0	0.160694	0	16	1									
RABGGTA	5875	broad.mit.edu	37	14	24740142	24740142	+	Silent	SNP	C	C	T			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr14:24740142C>T	uc001wof.2	-	2	437	c.15G>A	c.(13-15)CTG>CTA	p.L5L	RABGGTA_uc001woe.2_5'Flank|RABGGTA_uc001wog.2_Silent_p.L5L|RABGGTA_uc001woh.2_RNA|RABGGTA_uc001woi.2_RNA	NM_004581	NP_004572	Q92696	PGTA_HUMAN	Rab geranylgeranyltransferase alpha	5					visual perception		Rab geranylgeranyltransferase activity|zinc ion binding				0				GBM - Glioblastoma multiforme(265;0.0184)		TCTTCACCTTCAGGCGTCCGT	0.557		NaN											0	0	0	0.047766	0	8	2									
FAM179B	23116	broad.mit.edu	37	14	45432049	45432049	+	Missense_Mutation	SNP	G	G	C			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr14:45432049G>C	uc001wvv.2	+	1	634	c.425G>C	c.(424-426)CGA>CCA	p.R142P	FAM179B_uc001wvw.2_Missense_Mutation_p.R142P|FAM179B_uc010anc.2_RNA|KLHL28_uc001wvq.2_5'Flank|KLHL28_uc001wvr.2_5'Flank|FAM179B_uc010anb.1_Missense_Mutation_p.R142P|FAM179B_uc001wvu.2_Missense_Mutation_p.R142P	NM_015091	NP_055906	Q9Y4F4	F179B_HUMAN	hypothetical protein LOC23116	142							binding			skin(2)|upper_aerodigestive_tract(1)	3						GCACTGGGCCGAGTGCTTGTG	0.627		NaN											0	0	0	0.139131	0	54	11									
FAM179B	23116	broad.mit.edu	37	14	45432303	45432303	+	Missense_Mutation	SNP	G	G	C	rs148819135		TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr14:45432303G>C	uc001wvv.2	+	1	888	c.679G>C	c.(679-681)GAT>CAT	p.D227H	FAM179B_uc001wvw.2_Missense_Mutation_p.D227H|FAM179B_uc010anc.2_RNA|KLHL28_uc001wvq.2_5'Flank|KLHL28_uc001wvr.2_5'Flank|FAM179B_uc010anb.1_Missense_Mutation_p.D227H|FAM179B_uc001wvu.2_Missense_Mutation_p.D227H	NM_015091	NP_055906	Q9Y4F4	F179B_HUMAN	hypothetical protein LOC23116	227							binding			skin(2)|upper_aerodigestive_tract(1)	3						GGAAAGTACCGATGCCCGACT	0.493		NaN											0	0	0	0.139131	0	57	6									
TTC8	123016	broad.mit.edu	37	14	89307466	89307466	+	Missense_Mutation	SNP	A	A	G			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr14:89307466A>G	uc010ath.2	+	4	519	c.385A>G	c.(385-387)ATC>GTC	p.I129V	TTC8_uc010atg.1_RNA|TTC8_uc001xxl.2_5'UTR|TTC8_uc010ati.2_5'UTR|TTC8_uc001xxm.2_Missense_Mutation_p.I129V|TTC8_uc010atj.2_Intron|TTC8_uc001xxi.2_Missense_Mutation_p.I139V|TTC8_uc001xxj.2_Missense_Mutation_p.I129V|TTC8_uc001xxk.2_Missense_Mutation_p.I129V	NM_198309	NP_938051	Q8TAM2	TTC8_HUMAN	tetratricopeptide repeat domain 8 isoform B	139					cilium assembly|establishment of anatomical structure orientation|sensory processing	BBSome|centrosome|cilium membrane|microtubule basal body	protein binding				0						GGAACAGGCTATCAGAACACC	0.527		NaN							Bardet-Biedl_syndrome				0	0	0	0.219247	0	20	55									
MYO9A	4649	broad.mit.edu	37	15	72146901	72146901	+	Missense_Mutation	SNP	C	C	G			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr15:72146901C>G	uc002atl.3	-	35	6636	c.6163G>C	c.(6163-6165)GAG>CAG	p.E2055Q	MYO9A_uc002atj.2_5'UTR|MYO9A_uc002atk.2_Missense_Mutation_p.E850Q	NM_006901	NP_008832	B2RTY4	MYO9A_HUMAN	myosin IXA	2055	Tail.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction|visual perception	cytosol|integral to membrane|unconventional myosin complex	actin binding|ATP binding|GTPase activator activity|metal ion binding|motor activity			ovary(1)|pancreas(1)|skin(1)	3						GATGACAGCTCTGGATCATAC	0.348		NaN											0	0	0	0.139131	0	53	48									
TM6SF1	53346	broad.mit.edu	37	15	83776476	83776476	+	Missense_Mutation	SNP	C	C	G			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr15:83776476C>G	uc002bjp.2	+	1	153	c.44C>G	c.(43-45)TCG>TGG	p.S15W	TM6SF1_uc010bmq.2_Missense_Mutation_p.S15W|TM6SF1_uc002bjq.2_Missense_Mutation_p.S15W|TM6SF1_uc010bmr.2_RNA	NM_023003	NP_075379	Q9BZW5	TM6S1_HUMAN	transmembrane 6 superfamily member 1 isoform 1	15	Helical; (Potential).					integral to membrane				ovary(1)	1						CTGTCCCTCTCGGCCATCCCG	0.567		NaN											0	0	0	0.217242	0	5	4									
FANCI	55215	broad.mit.edu	37	15	89858609	89858609	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr15:89858609G>A	uc010bnp.1	+	37	4003	c.3913G>A	c.(3913-3915)GAA>AAA	p.E1305K	FANCI_uc002bnm.1_Missense_Mutation_p.E1245K|FANCI_uc002bnn.1_RNA|FANCI_uc002bnp.1_Missense_Mutation_p.E1065K|FANCI_uc002bnq.1_Missense_Mutation_p.E718K	NM_001113378	NP_001106849	Q9NVI1	FANCI_HUMAN	Fanconi anemia, complementation group I isoform	1305					cell cycle|DNA repair	nucleoplasm	protein binding			ovary(2)	2	Lung NSC(78;0.0472)|all_lung(78;0.089)					TGGTGAAGATGAAAATGAAGA	0.498		NaN						Direct_reversal_of_damage|Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				0	0	0	0.125774	0	31	39									
CHD2	1106	broad.mit.edu	37	15	93540489	93540489	+	Missense_Mutation	SNP	C	C	G			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr15:93540489C>G	uc002bsp.2	+	30	4316	c.3741C>G	c.(3739-3741)TGC>TGG	p.C1247W	CHD2_uc002bso.1_Missense_Mutation_p.C1247W	NM_001271	NP_001262	O14647	CHD2_HUMAN	chromodomain helicase DNA binding protein 2	1247					regulation of transcription from RNA polymerase II promoter	nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding			ovary(1)|skin(1)	2	Lung NSC(78;0.00976)|all_lung(78;0.016)		BRCA - Breast invasive adenocarcinoma(143;0.0282)|OV - Ovarian serous cystadenocarcinoma(32;0.0814)			TTAGATACTGCTTAACCTGTC	0.398		NaN											0	0	0	0.249174	0	24	48									
CHD2	1106	broad.mit.edu	37	15	93540504	93540504	+	Silent	SNP	C	C	G	rs141696596	by1000genomes	TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr15:93540504C>G	uc002bsp.2	+	30	4331	c.3756C>G	c.(3754-3756)GTC>GTG	p.V1252V	CHD2_uc002bso.1_Silent_p.V1252V	NM_001271	NP_001262	O14647	CHD2_HUMAN	chromodomain helicase DNA binding protein 2	1252					regulation of transcription from RNA polymerase II promoter	nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding			ovary(1)|skin(1)	2	Lung NSC(78;0.00976)|all_lung(78;0.016)		BRCA - Breast invasive adenocarcinoma(143;0.0282)|OV - Ovarian serous cystadenocarcinoma(32;0.0814)			CCTGTCGTGTCAAAGCTGCAC	0.388		NaN											0	0	0	0.116897	0	30	46									
TNRC6A	27327	broad.mit.edu	37	16	24815516	24815516	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr16:24815516G>A	uc002dmm.2	+	12	3827	c.3713G>A	c.(3712-3714)CGA>CAA	p.R1238Q	TNRC6A_uc010bxs.2_Missense_Mutation_p.R985Q|TNRC6A_uc002dmn.2_Missense_Mutation_p.R985Q|TNRC6A_uc002dmo.2_Missense_Mutation_p.R926Q|TNRC6A_uc002dmp.2_5'UTR|TNRC6A_uc002dmq.2_5'Flank	NM_014494	NP_055309	Q8NDV7	TNR6A_HUMAN	trinucleotide repeat containing 6A	1238	Sufficient for interaction with EIF2C1 and EIF2C4.				negative regulation of translation involved in gene silencing by miRNA	cytoplasmic mRNA processing body|micro-ribonucleoprotein complex	nucleotide binding|RNA binding			ovary(2)	2				GBM - Glioblastoma multiforme(48;0.0394)		CAAGACAAACGAATGGAGATA	0.398		NaN											0	0	0	0.099896	0	27	62									
FBXW10	10517	broad.mit.edu	37	17	18671866	18671866	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr17:18671866G>A	uc002guk.2	+	10	1956	c.1724G>A	c.(1723-1725)GGA>GAA	p.G575E	FBXW10_uc002guj.2_Missense_Mutation_p.G575E|FBXW10_uc002gul.2_Missense_Mutation_p.G604E|FBXW10_uc010cqh.1_Missense_Mutation_p.G575E	NM_031456	NP_113644	Q5XX13	FBW10_HUMAN	F-box and WD-40 domain protein 10	575	WD 6.									ovary(1)	1						GGCCATGAGGGAGCCGTGAAA	0.527		NaN											0	0	0	0.204396	0	19	39									
RHBDL3	162494	broad.mit.edu	37	17	30615898	30615898	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr17:30615898G>A	uc002hhe.1	+	4	396	c.382G>A	c.(382-384)GGG>AGG	p.G128R	RHBDL3_uc010csw.1_Missense_Mutation_p.G120R|RHBDL3_uc010csx.1_Missense_Mutation_p.G128R|RHBDL3_uc010csy.1_Missense_Mutation_p.G30R|RHBDL3_uc002hhf.1_Missense_Mutation_p.G30R	NM_138328	NP_612201	P58872	RHBL3_HUMAN	rhomboid protease 3	128					proteolysis	integral to membrane	calcium ion binding|serine-type endopeptidase activity			ovary(1)	1		Breast(31;0.116)|Ovarian(249;0.182)				GGAGGAGAAGGGGCTGAGCCT	0.592		NaN											0	0	0	0.189662	0	20	17									
SLFN12L	342615	broad.mit.edu	37	17	33807197	33807197	+	Missense_Mutation	SNP	C	C	A			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr17:33807197C>A	uc002hjn.2	-	3	998	c.119G>T	c.(118-120)GGA>GTA	p.G40V		NM_001145027	NP_001138499			schlafen family member 12-like											ovary(1)	1						TAAGCCATTTCCACGCAGAAA	0.398		NaN											1	0	1.15088e-07	0.146539	1.18924e-07	17	15									
DNAJC7	7266	broad.mit.edu	37	17	40169378	40169378	+	Silent	SNP	G	G	A			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr17:40169378G>A	uc002hyo.2	-	1	294	c.57C>T	c.(55-57)CTC>CTT	p.L19L	DNAJC7_uc010wgb.1_5'Flank|DNAJC7_uc010wgc.1_5'UTR|DNAJC7_uc002hyp.2_5'UTR|DNAJC7_uc010cxw.2_5'Flank|NKIRAS2_uc002hyq.2_5'Flank|NKIRAS2_uc010wgd.1_5'Flank|NKIRAS2_uc002hyr.2_5'Flank|NKIRAS2_uc002hys.2_5'Flank|NKIRAS2_uc010wge.1_5'Flank|NKIRAS2_uc002hyt.2_5'Flank	NM_003315	NP_003306	Q99615	DNJC7_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 7	19					chaperone cofactor-dependent protein refolding	cytoplasm|cytoskeleton|nucleus	heat shock protein binding|unfolded protein binding			ovary(1)	1		all_cancers(22;0.00273)|Breast(137;0.00104)|all_epithelial(22;0.0305)				CTTGGTCGTCGAGCAGCTCCG	0.657		NaN											0	0	0	0.139131	0	52	72									
MAP3K14	9020	broad.mit.edu	37	17	43345029	43345029	+	Silent	SNP	C	C	T			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr17:43345029C>T	uc002iiw.1	-	13	2179	c.2070G>A	c.(2068-2070)CCG>CCA	p.P690P	LOC100133991_uc010dah.2_Intron|LOC100133991_uc002iit.3_Intron|LOC100133991_uc010dai.2_Intron|MAP3K14_uc002iiu.1_Silent_p.P220P|MAP3K14_uc010daj.1_RNA|MAP3K14_uc002iiv.1_Silent_p.P274P	NM_003954	NP_003945	Q99558	M3K14_HUMAN	mitogen-activated protein kinase kinase kinase	690					cellular response to mechanical stimulus|I-kappaB kinase/NF-kappaB cascade|immune response|positive regulation of I-kappaB kinase/NF-kappaB cascade|T cell costimulation	cytosol	ATP binding|MAP kinase kinase kinase activity|NF-kappaB-inducing kinase activity|protein binding			central_nervous_system(3)|breast(2)|lung(1)|ovary(1)|stomach(1)	8						AAAGCTCTCTCGGCTGGGCAT	0.607		NaN											0	0	0	0.131918	0	46	60									
ABCC3	8714	broad.mit.edu	37	17	48741058	48741058	+	Missense_Mutation	SNP	A	A	G			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr17:48741058A>G	uc002isl.2	+	9	1095	c.1015A>G	c.(1015-1017)ATC>GTC	p.I339V	ABCC3_uc002isk.3_Missense_Mutation_p.I339V|ABCC3_uc002ism.2_Missense_Mutation_p.I21V	NM_003786	NP_003777	O15438	MRP3_HUMAN	ATP-binding cassette, sub-family C, member 3	339	Extracellular (By similarity).|ABC transmembrane type-1 1.				bile acid metabolic process	integral to plasma membrane|membrane fraction	ATP binding|bile acid-exporting ATPase activity|organic anion transmembrane transporter activity			skin(3)|central_nervous_system(1)	4			BRCA - Breast invasive adenocarcinoma(22;3.05e-09)		Glibenclamide(DB01016)	GATCAGGTTTATCTCCAACCC	0.587		NaN											0	0	0	0.108266	0	27	49									
UNC13D	201294	broad.mit.edu	37	17	73832317	73832317	+	Silent	SNP	G	G	A			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr17:73832317G>A	uc002jpp.2	-	16	1790	c.1410C>T	c.(1408-1410)TTC>TTT	p.F470F	UNC13D_uc010wsk.1_Silent_p.F470F|UNC13D_uc002jpq.1_Silent_p.F120F|UNC13D_uc010dgq.1_Silent_p.F266F	NM_199242	NP_954712	Q70J99	UN13D_HUMAN	unc-13 homolog D	470	Interaction with RAB27A.				positive regulation of exocytosis|regulation of mast cell degranulation	exocytic vesicle|late endosome|lysosome|membrane|recycling endosome	protein binding			upper_aerodigestive_tract(1)|skin(1)	2			all cancers(21;2.11e-06)|Epithelial(20;2.32e-06)|BRCA - Breast invasive adenocarcinoma(9;0.000618)|LUSC - Lung squamous cell carcinoma(166;0.154)			GCTTCAGGTGGAACCATTCAG	0.667		NaN							Familial_Hemophagocytic_Lymphohistiocytosis				0	0	0	0.058154	0	10	9									
CANT1	124583	broad.mit.edu	37	17	76993384	76993384	+	Silent	SNP	G	G	A			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr17:76993384G>A	uc002jwn.2	-	4	760	c.321C>T	c.(319-321)ATC>ATT	p.I107I	CANT1_uc002jwk.2_Silent_p.I107I|CANT1_uc002jwj.2_Silent_p.I107I|CANT1_uc002jwl.2_RNA|CANT1_uc002jwm.1_5'Flank	NM_001159772	NP_001153244	Q8WVQ1	CANT1_HUMAN	calcium activated nucleotidase 1	107	Lumenal (Potential).				positive regulation of I-kappaB kinase/NF-kappaB cascade	endoplasmic reticulum membrane|Golgi cisterna membrane|integral to membrane	calcium ion binding|nucleoside-diphosphatase activity|signal transducer activity				0			BRCA - Breast invasive adenocarcinoma(99;0.0362)|OV - Ovarian serous cystadenocarcinoma(97;0.139)			CGATAACTGCGATTCGATACC	0.577		NaN	T	ETV4	prostate								0	0	0	0.139131	0	109	127									
THOC4	10189	broad.mit.edu	37	17	79847100	79847100	+	Missense_Mutation	SNP	C	C	T			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr17:79847100C>T	uc002kbu.2	-	3	502	c.496G>A	c.(496-498)GCC>ACC	p.A166T	ANAPC11_uc002kbv.1_5'Flank|ANAPC11_uc002kbw.1_5'Flank|ANAPC11_uc002kbx.1_5'Flank|ANAPC11_uc002kby.1_5'Flank|ANAPC11_uc002kbz.1_5'Flank|ANAPC11_uc002kca.1_5'Flank|ANAPC11_uc002kcb.1_5'Flank|ANAPC11_uc002kcc.1_5'Flank	NM_005782	NP_005773	Q86V81	THOC4_HUMAN	THO complex 4	159	RRM.|Ala/Arg/Gly-rich.				intronless viral mRNA export from host nucleus|mRNA 3'-end processing|termination of RNA polymerase II transcription	catalytic step 2 spliceosome|cytosol|nuclear speck|transcription export complex	nucleotide binding|protein binding|RNA binding				0	all_neural(118;0.0878)|Ovarian(332;0.12)		BRCA - Breast invasive adenocarcinoma(99;0.013)|OV - Ovarian serous cystadenocarcinoma(97;0.0382)			GCCTTCAGGGCATCTGCCTTC	0.582		NaN											0	0	0	0.279207	0	26	26									
DCXR	51181	broad.mit.edu	37	17	79994847	79994847	+	Missense_Mutation	SNP	C	C	G			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr17:79994847C>G	uc002kdg.2	-	3	208	c.193G>C	c.(193-195)GAG>CAG	p.E65Q		NM_016286	NP_057370	Q7Z4W1	DCXR_HUMAN	dicarbonyl/L-xylulose reductase	65					D-xylose metabolic process|glucose metabolic process|protein homotetramerization|xylulose metabolic process	membrane	binding|L-xylulose reductase (NADP+) activity				0	all_neural(118;0.0878)|Ovarian(332;0.227)|all_lung(278;0.246)		BRCA - Breast invasive adenocarcinoma(99;0.0114)|OV - Ovarian serous cystadenocarcinoma(97;0.0191)			TCGGTGGCCTCCCAGTCACCC	0.677		NaN											0	0	0	0.184627	0	4	6									
HEXDC	284004	broad.mit.edu	37	17	80400259	80400259	+	Silent	SNP	G	G	A			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr17:80400259G>A	uc002kew.2	+	12	1511	c.1460G>A	c.(1459-1461)TGA>TAA	p.*487*	HEXDC_uc002kev.3_Missense_Mutation_p.E517K|HEXDC_uc010diq.2_Silent_p.L489L|HEXDC_uc010wvm.1_RNA			Q8WVB3	HEXDC_HUMAN	SubName: Full=Hexosaminidase (Glycosyl hydrolase family 20, catalytic domain) containing, isoform CRA_c; SubName: Full=Hexosaminidase D;	487					carbohydrate metabolic process	cytoplasm|nucleus	beta-N-acetylhexosaminidase activity|cation binding			ovary(1)|skin(1)	2	Breast(20;0.00106)|all_neural(118;0.0804)		OV - Ovarian serous cystadenocarcinoma(97;0.0143)|BRCA - Breast invasive adenocarcinoma(99;0.0369)			CAGGACCCCTGAGGGGAGAGC	0.701		NaN											0	0	0	0.125774	0	30	31									
C18orf19	125228	broad.mit.edu	37	18	13681707	13681707	+	Missense_Mutation	SNP	G	G	C			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr18:13681707G>C	uc010dlh.2	-	3	802	c.370C>G	c.(370-372)CAA>GAA	p.Q124E	C18orf19_uc010dlg.2_Missense_Mutation_p.Q124E|C18orf19_uc010dli.2_Missense_Mutation_p.Q124E|C18orf19_uc002ksj.3_Missense_Mutation_p.Q124E|C18orf19_uc010dlj.2_Intron	NM_001098801	NP_001092271	Q96ND0	CR019_HUMAN	hypothetical protein LOC125228	124	DUF1279.					integral to membrane				breast(2)	2						TTGAATCGTTGATAAAGACTA	0.388		NaN											0	0	0	0.139131	0	59	70									
ALKBH7	84266	broad.mit.edu	37	19	6372969	6372969	+	Silent	SNP	G	G	A			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr19:6372969G>A	uc002meo.1	+	1	526	c.138G>A	c.(136-138)GAG>GAA	p.E46E		NM_032306	NP_115682	Q9BT30	ALKB7_HUMAN	spermatogenesis associated 11 precursor	46						extracellular region|nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen				0						CAGAGGAGGAGACGCTGAGCC	0.736		NaN											0	0	0	0.248553	0	7	2									
MED26	9441	broad.mit.edu	37	19	16688392	16688392	+	Silent	SNP	G	G	T			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr19:16688392G>T	uc002nen.1	-	3	510	c.249C>A	c.(247-249)CTC>CTA	p.L83L	MED26_uc002nee.2_RNA	NM_004831	NP_004822	O95402	MED26_HUMAN	mediator complex subunit 26	83	TFIIS N-terminal.				regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	DNA binding|RNA polymerase II transcription cofactor activity|transcription coactivator activity			ovary(2)	2						CCGGCTCGATGAGCTTCTGCC	0.672		NaN											1	0	2.32416e-17	0.249174	2.53693e-17	24	26									
PDE4C	5143	broad.mit.edu	37	19	18327578	18327578	+	Silent	SNP	C	C	G			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr19:18327578C>G	uc010xqc.1	-	12	1938	c.1458G>C	c.(1456-1458)CTG>CTC	p.L486L	PDE4C_uc002nik.3_Silent_p.L486L|PDE4C_uc002nil.3_Silent_p.L486L|PDE4C_uc002nif.3_Silent_p.L255L|PDE4C_uc002nig.3_Silent_p.L201L|PDE4C_uc002nih.3_Silent_p.L256L|PDE4C_uc010ebk.2_Silent_p.L380L|PDE4C_uc002nii.3_Silent_p.L454L|PDE4C_uc010ebl.2_Silent_p.L200L|PDE4C_uc010xqd.1_Silent_p.L255L	NM_001098819	NP_001092289	Q08493	PDE4C_HUMAN	phosphodiesterase 4C isoform PDE4C-2	486					signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding			ovary(2)|skin(2)|central_nervous_system(1)	5					Dyphylline(DB00651)	TGCGCAGACTCAGTCGCTGCT	0.617		NaN											0	0	0	0.257332	0	42	62									
HAPLN4	404037	broad.mit.edu	37	19	19371709	19371709	+	Missense_Mutation	SNP	C	C	T	rs114536312	byFrequency	TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr19:19371709C>T	uc002nmb.2	-	3	452	c.397G>A	c.(397-399)GTC>ATC	p.V133I	HAPLN4_uc002nmc.2_Missense_Mutation_p.V133I	NM_023002	NP_075378	Q86UW8	HPLN4_HUMAN	hyaluronan and proteoglycan link protein 4	133	Ig-like C2-type.				cell adhesion	proteinaceous extracellular matrix	hyaluronic acid binding			pancreas(1)	1			Epithelial(12;0.00575)			TGCAGCGTGACGTTGCGGAGG	0.652		NaN											0	0	0	0.294199	0	27	49									
ANKRD27	84079	broad.mit.edu	37	19	33113450	33113450	+	Missense_Mutation	SNP	G	G	C			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr19:33113450G>C	uc002ntn.1	-	18	1861	c.1705C>G	c.(1705-1707)CTA>GTA	p.L569V		NM_032139	NP_115515	Q96NW4	ANR27_HUMAN	ankyrin repeat domain 27 (VPS9 domain)	569	ANK 5.				early endosome to late endosome transport	early endosome|lysosome	GTPase activator activity|guanyl-nucleotide exchange factor activity			ovary(2)|skin(2)|pancreas(1)	5	Esophageal squamous(110;0.137)					GCAATGTGTAGAGGGGTGTCT	0.542		NaN											0	0	0	0.139131	0	67	84									
ERCC2	2068	broad.mit.edu	37	19	45868143	45868143	+	Silent	SNP	G	G	A			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr19:45868143G>A	uc002pbj.2	-	7	594	c.547C>T	c.(547-549)CTG>TTG	p.L183L	ERCC2_uc002pbi.2_5'Flank|ERCC2_uc010ejz.2_Intron|ERCC2_uc002pbk.2_Silent_p.L159L|ERCC2_uc002pbl.3_Silent_p.L159L|ERCC2_uc010xxj.1_Intron	NM_000400	NP_000391	P18074	ERCC2_HUMAN	excision repair cross-complementing rodent	183	Helicase ATP-binding.				cell cycle checkpoint|chromosome segregation|hair cell differentiation|induction of apoptosis|interspecies interaction between organisms|mRNA capping|nucleotide-excision repair, DNA damage removal|nucleotide-excision repair, DNA incision|positive regulation of transcription from RNA polymerase II promoter|positive regulation of viral transcription|protein phosphorylation|response to oxidative stress|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase I promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|UV protection|viral reproduction	cytoplasm|holo TFIIH complex|MMXD complex	5'-3' DNA helicase activity|ATP binding|ATP-dependent DNA helicase activity|DNA binding|iron-sulfur cluster binding|metal ion binding|protein C-terminus binding|protein N-terminus binding			lung(2)|pancreas(1)	3		Ovarian(192;0.0728)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.0226)		CGCCGCCCCAGGGCCTTCAGG	0.632		NaN	Mis|N|F|S			skin basal cell|skin squamous cell|melanoma		Direct_reversal_of_damage|NER	Xeroderma_Pigmentosum				0	0	0	0.219247	0	20	20									
HIF3A	64344	broad.mit.edu	37	19	46823770	46823770	+	Silent	SNP	C	C	A			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr19:46823770C>A	uc002peh.2	+	9	1125	c.1096C>A	c.(1096-1098)CGG>AGG	p.R366R	HIF3A_uc002peg.3_Silent_p.R366R|HIF3A_uc010xxx.1_RNA|HIF3A_uc002pei.3_Silent_p.R310R|HIF3A_uc002pej.1_Silent_p.R297R|HIF3A_uc002pek.2_Silent_p.R310R|HIF3A_uc010xxy.1_Silent_p.R297R|HIF3A_uc002pel.2_Silent_p.R364R|HIF3A_uc010xxz.1_Silent_p.R315R	NM_152795	NP_690008	Q9Y2N7	HIF3A_HUMAN	hypoxia inducible factor 3, alpha subunit	366					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|signal transducer activity			upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	3		Ovarian(192;0.00965)|all_neural(266;0.0887)		OV - Ovarian serous cystadenocarcinoma(262;0.00204)|all cancers(93;0.0107)|GBM - Glioblastoma multiforme(486;0.0489)|Epithelial(262;0.136)		ACCCATTCAGCGGGGCGCCCC	0.657		NaN											1	0	5.20006e-24	0.301197	5.75721e-24	44	39									
TULP2	7288	broad.mit.edu	37	19	49384274	49384274	+	Silent	SNP	G	G	A			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr19:49384274G>A	uc002pkz.2	-	13	1708	c.1557C>T	c.(1555-1557)TTC>TTT	p.F519F		NM_003323	NP_003314	O00295	TULP2_HUMAN	tubby like protein 2	519					visual perception	cytoplasm|extracellular region				ovary(1)|kidney(1)|skin(1)	3		all_epithelial(76;5.29e-07)|all_lung(116;1.7e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.000259)|all cancers(93;0.000435)|Epithelial(262;0.0221)|GBM - Glioblastoma multiforme(486;0.0234)		GCTTCTAATTGAAACTGGACA	0.512		NaN											0	0	0	0.134883	0	28	49									
TULP2	7288	broad.mit.edu	37	19	49384281	49384281	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr19:49384281G>A	uc002pkz.2	-	13	1701	c.1550C>T	c.(1549-1551)TCC>TTC	p.S517F		NM_003323	NP_003314	O00295	TULP2_HUMAN	tubby like protein 2	517					visual perception	cytoplasm|extracellular region				ovary(1)|kidney(1)|skin(1)	3		all_epithelial(76;5.29e-07)|all_lung(116;1.7e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.000259)|all cancers(93;0.000435)|Epithelial(262;0.0221)|GBM - Glioblastoma multiforme(486;0.0234)		ATTGAAACTGGACAAGCAGAT	0.517		NaN											0	0	0	0.173368	0	31	48									
TPO	7173	broad.mit.edu	37	2	1437377	1437377	+	Missense_Mutation	SNP	C	C	T			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr2:1437377C>T	uc002qww.2	+	4	438	c.347C>T	c.(346-348)ACG>ATG	p.T116M	TPO_uc010ewj.2_Intron|TPO_uc010yin.1_Missense_Mutation_p.T116M|TPO_uc002qwu.2_Missense_Mutation_p.T116M|TPO_uc002qwr.2_Missense_Mutation_p.T116M|TPO_uc002qwx.2_Missense_Mutation_p.T116M|TPO_uc010yio.1_Missense_Mutation_p.T116M|TPO_uc010yip.1_Missense_Mutation_p.T116M	NM_000547	NP_000538	P07202	PERT_HUMAN	thyroid peroxidase isoform a	116	Extracellular (Potential).				cellular nitrogen compound metabolic process|hormone biosynthetic process|hydrogen peroxide catabolic process	cell surface|cytoplasm|integral to plasma membrane	calcium ion binding|heme binding|iodide peroxidase activity			ovary(7)|pancreas(6)|skin(5)|lung(1)|kidney(1)	20	all_hematologic(175;0.0487)|Acute lymphoblastic leukemia(172;0.0627)	all_cancers(51;0.0338)		all cancers(51;0.0356)|OV - Ovarian serous cystadenocarcinoma(76;0.0748)|Epithelial(75;0.12)	Carbimazole(DB00389)|Methimazole(DB00763)|Propylthiouracil(DB00550)	CAGCATCCAACGGGTAATGTG	0.498		NaN											0	0	0	0.27861	0	8	5									
CCT7	10574	broad.mit.edu	37	2	73466864	73466864	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr2:73466864G>A	uc002siz.2	+	2	202	c.100G>A	c.(100-102)GAG>AAG	p.E34K	CCT7_uc002sja.2_Intron|CCT7_uc010yrf.1_5'UTR|CCT7_uc010feu.2_Missense_Mutation_p.E34K|CCT7_uc010yrg.1_5'UTR|CCT7_uc010yrh.1_5'UTR|CCT7_uc010yri.1_Intron	NM_006429	NP_006420	Q99832	TCPH_HUMAN	chaperonin containing TCP1, subunit 7 isoform a	34					'de novo' posttranslational protein folding		ATP binding|unfolded protein binding				0						GGTGATTGCTGAGGCTGTAAG	0.522		NaN											0	0	0	0.105934	0	14	13									
IL18R1	8809	broad.mit.edu	37	2	103013262	103013262	+	Silent	SNP	G	G	A	rs138611669		TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr2:103013262G>A	uc002tbw.3	+	11	1692	c.1542G>A	c.(1540-1542)AAG>AAA	p.K514K	IL18R1_uc010ywc.1_Silent_p.K513K|IL18R1_uc010ywd.1_Silent_p.K358K|IL18R1_uc010fiy.2_Silent_p.K514K	NM_003855	NP_003846	Q13478	IL18R_HUMAN	interleukin 18 receptor 1 precursor	514	TIR.|Cytoplasmic (Potential).				innate immune response	integral to membrane|plasma membrane	interleukin-1 receptor activity			ovary(2)|pancreas(1)	3						GGTTCTGGAAGAACCTTCTTT	0.413		NaN											0	0	0	0.125774	0	29	52									
MFSD9	84804	broad.mit.edu	37	2	103343352	103343352	+	Missense_Mutation	SNP	C	C	G			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr2:103343352C>G	uc002tcb.2	-	4	447	c.379G>C	c.(379-381)GGA>CGA	p.G127R	MFSD9_uc010fja.2_RNA	NM_032718	NP_116107	Q8NBP5	MFSD9_HUMAN	major facilitator superfamily domain containing	127	Helical; (Potential).				transmembrane transport	integral to membrane|plasma membrane	transporter activity			ovary(2)|breast(2)	4						GTGGCTGCTCCGAGAAGGAGA	0.483		NaN											0	0	0	0.26419	0	25	22									
RGPD3	653489	broad.mit.edu	37	2	107084739	107084739	+	Silent	SNP	A	A	G	rs6718521	by1000genomes	TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr2:107084739A>G	uc010ywi.1	-	1	63	c.6T>C	c.(4-6)AGT>AGC	p.S2S		NM_001144013	NP_001137485	A6NKT7	RGPD3_HUMAN	RANBP2-like and GRIP domain containing 3	2					intracellular transport		binding			ovary(1)	1						CCTTGCTGCAACTCATCGCGC	0.657		NaN											0	0	0	0.115264	0	2	4									
GULP1	51454	broad.mit.edu	37	2	189449086	189449086	+	Missense_Mutation	SNP	A	A	G			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr2:189449086A>G	uc010fru.2	+	10	1165	c.704A>G	c.(703-705)AAT>AGT	p.N235S	GULP1_uc002uqd.2_Missense_Mutation_p.N235S|GULP1_uc010zfw.1_Missense_Mutation_p.N132S|GULP1_uc002uqf.2_Missense_Mutation_p.N235S|GULP1_uc002uqg.2_Missense_Mutation_p.N235S|GULP1_uc002uqh.1_Missense_Mutation_p.N55S	NM_016315	NP_057399	Q9UBP9	GULP1_HUMAN	GULP, engulfment adaptor PTB domain containing	235					apoptosis|lipid transport|phagocytosis, engulfment	cytoplasm|intracellular membrane-bounded organelle	signal transducer activity			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(117;0.0423)|Epithelial(96;0.158)			CCTACTCGCAATGGCACACAG	0.408		NaN											0	0	0	0.249174	0	22	72									
FN1	2335	broad.mit.edu	37	2	216249686	216249686	+	Silent	SNP	C	C	T	rs142628915		TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr2:216249686C>T	uc002vfa.2	-	29	4892	c.4626G>A	c.(4624-4626)CCG>CCA	p.P1542P	FN1_uc002vfb.2_Silent_p.P1451P|FN1_uc002vfc.2_Silent_p.P1451P|FN1_uc002vfd.2_Silent_p.P1542P|FN1_uc002vfe.2_Silent_p.P1451P|FN1_uc002vff.2_Silent_p.P1451P|FN1_uc002vfg.2_Silent_p.P1451P|FN1_uc002vfh.2_Silent_p.P1451P|FN1_uc002vfi.2_Silent_p.P1542P|FN1_uc002vfj.2_Silent_p.P1542P|FN1_uc002vez.2_5'UTR|FN1_uc010zjp.1_Silent_p.P169P|FN1_uc010fvc.1_5'Flank|FN1_uc010fvd.1_5'Flank	NM_212482	NP_997647	P02751	FINC_HUMAN	fibronectin 1 isoform 1 preproprotein	1545	Fibronectin type-III 11.				acute-phase response|angiogenesis|leukocyte migration|peptide cross-linking|platelet activation|platelet degranulation|regulation of cell shape|substrate adhesion-dependent cell spreading	ER-Golgi intermediate compartment|fibrinogen complex|platelet alpha granule lumen|proteinaceous extracellular matrix	collagen binding|extracellular matrix structural constituent|heparin binding			central_nervous_system(7)|large_intestine(2)|breast(2)|ovary(1)|pancreas(1)	13		Renal(323;0.127)		Epithelial(149;9.59e-07)|all cancers(144;0.000174)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)	Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	CCAGGTCCCTCGGAACATCAG	0.418		NaN											0	0	0	0.080935	0	11	8									
FARP2	9855	broad.mit.edu	37	2	242415381	242415381	+	Silent	SNP	G	G	A			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr2:242415381G>A	uc002wbi.1	+	19	2358	c.2241G>A	c.(2239-2241)GAG>GAA	p.E747E	hsa-mir-3133|MI0014153_5'Flank	NM_014808	NP_055623	O94887	FARP2_HUMAN	FERM, RhoGEF and pleckstrin domain protein 2	747					axon guidance|neuron remodeling|Rac protein signal transduction|regulation of Rho protein signal transduction	cytoskeleton|cytosol|extrinsic to membrane	cytoskeletal protein binding|Rho guanyl-nucleotide exchange factor activity			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3		all_cancers(19;4.88e-34)|all_epithelial(40;4.81e-14)|Breast(86;0.000141)|Renal(207;0.0143)|all_lung(227;0.0344)|Lung NSC(271;0.0886)|Ovarian(221;0.0905)|Esophageal squamous(248;0.131)|all_hematologic(139;0.182)|Melanoma(123;0.238)		Epithelial(32;1.81e-33)|all cancers(36;1.61e-30)|OV - Ovarian serous cystadenocarcinoma(60;6.83e-15)|Kidney(56;1.19e-08)|KIRC - Kidney renal clear cell carcinoma(57;8.98e-08)|BRCA - Breast invasive adenocarcinoma(100;1.49e-06)|Lung(119;0.000152)|LUSC - Lung squamous cell carcinoma(224;0.00125)|Colorectal(34;0.0199)|COAD - Colon adenocarcinoma(134;0.121)		TGGGCATAGAGAACCTCATTG	0.448		NaN											0	0	0	0.217242	0	5	1									
TGM3	7053	broad.mit.edu	37	20	2312720	2312720	+	Missense_Mutation	SNP	C	C	T			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr20:2312720C>T	uc002wfx.3	+	10	1503	c.1406C>T	c.(1405-1407)ACG>ATG	p.T469M		NM_003245	NP_003236	Q08188	TGM3_HUMAN	transglutaminase 3 precursor	469					cell envelope organization|hair follicle morphogenesis|keratinization|peptide cross-linking|protein tetramerization	cytoplasm|extrinsic to internal side of plasma membrane	acyltransferase activity|calcium ion binding|GDP binding|GTP binding|GTPase activity|magnesium ion binding|protein-glutamine gamma-glutamyltransferase activity			large_intestine(4)|ovary(3)|breast(1)|skin(1)	9					L-Glutamine(DB00130)	TTTGCCGCGACGTCTTCAATG	0.517		NaN											0	0	0	0.173368	0	35	37									
ASXL1	171023	broad.mit.edu	37	20	31021691	31021691	+	Nonsense_Mutation	SNP	A	A	T			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr20:31021691A>T	uc002wxs.2	+	11	2116	c.1690A>T	c.(1690-1692)AAA>TAA	p.K564*	ASXL1_uc010geb.2_Nonsense_Mutation_p.K455*	NM_015338	NP_056153	Q8IXJ9	ASXL1_HUMAN	additional sex combs like 1 isoform 1	564					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	PR-DUB complex	metal ion binding|protein binding			haematopoietic_and_lymphoid_tissue(239)|large_intestine(6)|central_nervous_system(2)|ovary(1)	248						ACAGCCCACTAAAGAGGAGCC	0.527		NaN	F|N|Mis		MDS|CMML								0	0	0	0.139131	0	46	78									
SLC35C2	51006	broad.mit.edu	37	20	44979476	44979476	+	Silent	SNP	G	G	T			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr20:44979476G>T	uc002xro.2	-	9	1432	c.891C>A	c.(889-891)CTC>CTA	p.L297L	SLC35C2_uc002xrp.2_Silent_p.L276L|SLC35C2_uc002xrq.2_Silent_p.L297L|SLC35C2_uc002xrr.2_Silent_p.L297L|SLC35C2_uc010zxn.1_Silent_p.L162L|SLC35C2_uc010zxo.1_Silent_p.L183L|SLC35C2_uc010zxp.1_Silent_p.L326L	NM_173179	NP_775271	Q9NQQ7	S35C2_HUMAN	solute carrier family 35, member C2 isoform a	297	Helical; (Potential).				transport	integral to membrane				ovary(1)	1		Myeloproliferative disorder(115;0.0122)				GCCAGTTCAGGAGGCTGATCT	0.577		NaN											1	0	2.23348e-06	0.146539	2.29265e-06	16	67									
C21orf29	54084	broad.mit.edu	37	21	45945598	45945598	+	Missense_Mutation	SNP	C	C	T			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr21:45945598C>T	uc002zfe.1	-	8	1340	c.1274G>A	c.(1273-1275)CGA>CAA	p.R425Q	C21orf29_uc010gpv.1_Missense_Mutation_p.R357Q	NM_144991	NP_659428	Q8WU66	TSEAR_HUMAN	chromosome 21 open reading frame 29 precursor	425	EAR 3.				cell adhesion	extracellular region	structural molecule activity				0						CTCCCAGTCTCGGGCGCTGTG	0.572		NaN											0	0	0	0.139131	0	54	87									
DAZL	1618	broad.mit.edu	37	3	16636050	16636050	+	Missense_Mutation	SNP	A	A	G			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr3:16636050A>G	uc003cbb.2	-	8	905	c.611T>C	c.(610-612)GTT>GCT	p.V204A	DAZL_uc003cba.2_Missense_Mutation_p.V224A	NM_001351	NP_001342	Q92904	DAZL_HUMAN	deleted in azoospermia-like	204					germ cell development|multicellular organismal development|positive regulation of translational initiation|spermatogenesis	cytoplasm|nucleus	nucleotide binding|protein binding|RNA binding|translation activator activity				0						CGGAGGTACAACATAGCTCCT	0.299		NaN											0	0	0	0.058154	0	10	10									
KCNH8	131096	broad.mit.edu	37	3	19384094	19384094	+	Missense_Mutation	SNP	G	G	T			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr3:19384094G>T	uc003cbk.1	+	4	653	c.458G>T	c.(457-459)AGA>ATA	p.R153I	KCNH8_uc011awe.1_Missense_Mutation_p.R153I|KCNH8_uc010hex.1_5'UTR	NM_144633	NP_653234	Q96L42	KCNH8_HUMAN	potassium voltage-gated channel, subfamily H,	153	Cytoplasmic (Potential).					integral to membrane	two-component sensor activity			lung(4)|ovary(1)	5						GTCAAAGGAAGATCAAGAGCA	0.448		NaN											1	0	2.79863e-10	0.099896	2.99164e-10	26	33									
CCR4	1233	broad.mit.edu	37	3	32995542	32995542	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr3:32995542G>A	uc003cfg.1	+	2	796	c.628G>A	c.(628-630)GGA>AGA	p.G210R		NM_005508	NP_005499	P51679	CCR4_HUMAN	chemokine (C-C motif) receptor 4	210	Helical; Name=5; (Potential).				chemotaxis|elevation of cytosolic calcium ion concentration|immune response|inflammatory response	integral to plasma membrane				lung(1)	1						CAACATTCTCGGATTGGTGAT	0.458		NaN											0	0	0	0.139131	0	51	68									
BSN	8927	broad.mit.edu	37	3	49692105	49692105	+	Missense_Mutation	SNP	C	C	T	rs141249428	byFrequency	TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr3:49692105C>T	uc003cxe.3	+	5	5230	c.5116C>T	c.(5116-5118)CGG>TGG	p.R1706W		NM_003458	NP_003449	Q9UPA5	BSN_HUMAN	bassoon protein	1706					synaptic transmission	cell junction|cytoplasm|cytoskeleton|nucleus|synaptosome	metal ion binding			ovary(5)|pancreas(1)|central_nervous_system(1)|skin(1)	8				BRCA - Breast invasive adenocarcinoma(193;6.66e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.0032)|Kidney(197;0.00336)		AATCCCAGGACGGCAGTCGAC	0.587		NaN											0	0	0	0.246493	0	42	72									
ITIH1	3697	broad.mit.edu	37	3	52813598	52813598	+	Silent	SNP	G	G	A			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr3:52813598G>A	uc003dfs.2	+	5	585	c.561G>A	c.(559-561)GTG>GTA	p.V187V	ITIH1_uc010hmn.1_RNA	NM_002215	NP_002206	P19827	ITIH1_HUMAN	inter-alpha (globulin) inhibitor H1	187					hyaluronan metabolic process|leukocyte activation	extracellular region	calcium ion binding|serine-type endopeptidase inhibitor activity			ovary(3)	3				BRCA - Breast invasive adenocarcinoma(193;7.04e-05)|Kidney(197;0.000659)|KIRC - Kidney renal clear cell carcinoma(197;0.000795)|OV - Ovarian serous cystadenocarcinoma(275;0.0498)		AGCAGCTGGTGCATCATTTTG	0.532		NaN											0	0	0	0.235728	0	38	31									
SLMAP	7871	broad.mit.edu	37	3	57850350	57850350	+	Nonsense_Mutation	SNP	G	G	T	rs138089766		TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr3:57850350G>T	uc003dje.1	+	10	1247	c.1042G>T	c.(1042-1044)GAA>TAA	p.E348*	SLMAP_uc003djc.1_Nonsense_Mutation_p.E348*|SLMAP_uc003djd.1_Nonsense_Mutation_p.E348*|SLMAP_uc003djf.1_Nonsense_Mutation_p.E348*|SLMAP_uc003djg.1_5'UTR	NM_007159	NP_009090	Q14BN4	SLMAP_HUMAN	sarcolemma associated protein	348	Potential.|Cytoplasmic (Potential).				muscle contraction|protein folding	integral to plasma membrane|microtubule organizing center|prefoldin complex|sarcolemma|smooth endoplasmic reticulum	unfolded protein binding				0				BRCA - Breast invasive adenocarcinoma(55;0.000271)|KIRC - Kidney renal clear cell carcinoma(284;0.0602)|Kidney(284;0.0754)|OV - Ovarian serous cystadenocarcinoma(275;0.182)		TAAAATAGATGAAATGGAAGA	0.353		NaN											1	0	1.32136e-16	0.268233	1.43224e-16	44	51									
PLXND1	23129	broad.mit.edu	37	3	129324823	129324823	+	Silent	SNP	G	G	A			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr3:129324823G>A	uc003emx.2	-	1	760	c.660C>T	c.(658-660)TTC>TTT	p.F220F		NM_015103	NP_055918	Q9Y4D7	PLXD1_HUMAN	plexin D1 precursor	220	Extracellular (Potential).|Sema.				axon guidance	integral to membrane|intracellular|plasma membrane				large_intestine(1)	1						TGCGCGGGAAGAAGGAGCTGC	0.607		NaN											0	0	0	0.09319	0	12	16									
KLHL24	54800	broad.mit.edu	37	3	183368873	183368873	+	Silent	SNP	G	G	C			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr3:183368873G>C	uc003flv.2	+	3	1024	c.729G>C	c.(727-729)CTG>CTC	p.L243L	KLHL24_uc003flw.2_Silent_p.L243L|KLHL24_uc003flx.2_Silent_p.L243L	NM_017644	NP_060114	Q6TFL4	KLH24_HUMAN	DRE1 protein	243	BACK.					axon|cytoplasm|perikaryon				ovary(1)	1	all_cancers(143;2.88e-10)|Ovarian(172;0.0303)		all cancers(12;1.43e-42)|Epithelial(37;1.73e-36)|OV - Ovarian serous cystadenocarcinoma(80;8.75e-22)			CCGTTGATCTGAGAAGACCAC	0.423		NaN											0	0	0	0.116897	0	30	38									
KLHL24	54800	broad.mit.edu	37	3	183368878	183368878	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr3:183368878G>A	uc003flv.2	+	3	1029	c.734G>A	c.(733-735)AGA>AAA	p.R245K	KLHL24_uc003flw.2_Missense_Mutation_p.R245K|KLHL24_uc003flx.2_Missense_Mutation_p.R245K	NM_017644	NP_060114	Q6TFL4	KLH24_HUMAN	DRE1 protein	245	BACK.					axon|cytoplasm|perikaryon				ovary(1)	1	all_cancers(143;2.88e-10)|Ovarian(172;0.0303)		all cancers(12;1.43e-42)|Epithelial(37;1.73e-36)|OV - Ovarian serous cystadenocarcinoma(80;8.75e-22)			GATCTGAGAAGACCACTGTTA	0.423		NaN											0	0	0	0.294199	0	27	35									
KLHL24	54800	broad.mit.edu	37	3	183369003	183369003	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr3:183369003G>A	uc003flv.2	+	3	1154	c.859G>A	c.(859-861)GAA>AAA	p.E287K	KLHL24_uc003flw.2_Missense_Mutation_p.E287K|KLHL24_uc003flx.2_Missense_Mutation_p.E287K	NM_017644	NP_060114	Q6TFL4	KLH24_HUMAN	DRE1 protein	287						axon|cytoplasm|perikaryon				ovary(1)	1	all_cancers(143;2.88e-10)|Ovarian(172;0.0303)		all cancers(12;1.43e-42)|Epithelial(37;1.73e-36)|OV - Ovarian serous cystadenocarcinoma(80;8.75e-22)			GTTGTTGCATGAAGCAAGACG	0.418		NaN											0	0	0	0.249174	0	19	24									
ARAP2	116984	broad.mit.edu	37	4	36130168	36130168	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr4:36130168C>T	uc003gsq.1	-	21	3965	c.3627G>A	c.(3625-3627)TGG>TGA	p.W1209*		NM_015230	NP_056045	Q8WZ64	ARAP2_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH	1209	Rho-GAP.				regulation of ARF GTPase activity|small GTPase mediated signal transduction	cytosol	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|zinc ion binding			ovary(1)|pancreas(1)|skin(1)	3						AAGCAGAGATCCAATATGGGT	0.318		NaN											0	0	0	0.234183	0	22	37									
WDR19	57728	broad.mit.edu	37	4	39233498	39233498	+	Silent	SNP	C	C	T			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr4:39233498C>T	uc003gtv.2	+	18	2218	c.2064C>T	c.(2062-2064)CAC>CAT	p.H688H	WDR19_uc011byi.1_Silent_p.H528H|WDR19_uc003gtw.1_Silent_p.H285H	NM_025132	NP_079408	Q8NEZ3	WDR19_HUMAN	WD repeat domain 19	688					cell projection organization	microtubule basal body|motile cilium|photoreceptor connecting cilium	binding			large_intestine(1)	1						GTCTACATCACATGGAAGTGG	0.413		NaN											0	0	0	0.125774	0	29	48									
COX7B2	170712	broad.mit.edu	37	4	46737171	46737171	+	Silent	SNP	G	G	A			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr4:46737171G>A	uc003gxf.2	-	3	219	c.39C>T	c.(37-39)CTC>CTT	p.L13L	COX7B2_uc010ige.2_RNA	NM_130902	NP_570972	Q8TF08	CX7B2_HUMAN	cytochrome c oxidase subunit VIIb2 precursor	13						integral to membrane|mitochondrial respiratory chain	cytochrome-c oxidase activity				0						TTTGAATCTTGAGACTGCTTA	0.423		NaN											0	0	0	0.203993	0	38	61									
FRYL	285527	broad.mit.edu	37	4	48549632	48549632	+	Missense_Mutation	SNP	T	T	A			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr4:48549632T>A	uc003gyh.1	-	41	5648	c.5043A>T	c.(5041-5043)AAA>AAT	p.K1681N	FRYL_uc003gyg.1_Missense_Mutation_p.K377N|FRYL_uc003gyi.1_Missense_Mutation_p.K570N|FRYL_uc003gyj.1_5'Flank	NM_015030	NP_055845	O94915	FRYL_HUMAN	furry-like	1681					regulation of transcription, DNA-dependent|transcription, DNA-dependent		protein binding			skin(1)	1						GTGCAACTTGTTTGACTGTAA	0.343		NaN											0	0	0	0.134883	0	28	21									
RXFP1	59350	broad.mit.edu	37	4	159547979	159547979	+	Missense_Mutation	SNP	G	G	C			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr4:159547979G>C	uc003ipz.2	+	10	845	c.763G>C	c.(763-765)GAA>CAA	p.E255Q	RXFP1_uc010iqj.1_Missense_Mutation_p.E84Q|RXFP1_uc011cja.1_Intron|RXFP1_uc010iqo.2_Missense_Mutation_p.E255Q|RXFP1_uc011cjb.1_Missense_Mutation_p.E201Q|RXFP1_uc010iqk.2_Missense_Mutation_p.E123Q|RXFP1_uc011cjc.1_Missense_Mutation_p.E174Q|RXFP1_uc011cjd.1_Missense_Mutation_p.E174Q|RXFP1_uc010iql.2_Intron|RXFP1_uc011cje.1_Missense_Mutation_p.E282Q|RXFP1_uc010iqm.2_Missense_Mutation_p.E222Q|RXFP1_uc011cjf.1_Missense_Mutation_p.E125Q|RXFP1_uc010iqn.2_Missense_Mutation_p.E201Q	NM_021634	NP_067647	Q9HBX9	RXFP1_HUMAN	relaxin/insulin-like family peptide receptor 1	255	Extracellular (Potential).|LRR 5.					integral to membrane|plasma membrane	G-protein coupled receptor activity|metal ion binding				0	all_hematologic(180;0.24)	Renal(120;0.0854)		COAD - Colon adenocarcinoma(41;0.0219)		CAGGGACCTTGAAGGCAACCA	0.264		NaN											0	0	0	0.234183	0	18	21									
PLEKHG4B	153478	broad.mit.edu	37	5	163407	163407	+	Missense_Mutation	SNP	C	C	G			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr5:163407C>G	uc003jak.2	+	11	2202	c.2152C>G	c.(2152-2154)CAT>GAT	p.H718D		NM_052909	NP_443141	Q96PX9	PKH4B_HUMAN	pleckstrin homology domain containing, family G	718					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			skin(2)	2			all cancers(22;0.0253)|Lung(60;0.113)	Kidney(1;0.119)		CCCCAGGAAACATCCCCAGAA	0.607		NaN											0	0	0	0.139131	0	67	82									
EGFLAM	133584	broad.mit.edu	37	5	38370443	38370443	+	Silent	SNP	G	G	A			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr5:38370443G>A	uc003jlc.1	+	6	915	c.591G>A	c.(589-591)CAG>CAA	p.Q197Q	EGFLAM_uc003jlb.1_Silent_p.Q197Q	NM_152403	NP_689616	Q63HQ2	EGFLA_HUMAN	EGF-like, fibronectin type III and laminin G	197	Fibronectin type-III 2.					cell junction|proteinaceous extracellular matrix|synapse				pancreas(3)|skin(3)|ovary(1)	7	all_lung(31;0.000385)					AGCGGATCCAGATGGACTCCA	0.507		NaN											0	0	0	0.235728	0	40	61									
PAIP1	10605	broad.mit.edu	37	5	43547922	43547922	+	Missense_Mutation	SNP	C	C	G			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08			C	G	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr5:43547922C>G	uc003job.2	-	3	776	c.529G>C	c.(529-531)GAA>CAA	p.E177Q	PAIP1_uc003joa.2_Missense_Mutation_p.E98Q|PAIP1_uc010ivp.2_Missense_Mutation_p.E98Q|PAIP1_uc010ivo.2_RNA|PAIP1_uc003joc.2_Missense_Mutation_p.E65Q	NM_006451	NP_006442	Q9H074	PAIP1_HUMAN	poly(A) binding protein interacting protein 1	177	MIF4G.				mRNA stabilization|nuclear-transcribed mRNA poly(A) tail shortening|translational initiation	cytosol	protein binding|RNA binding|translation activator activity			ovary(1)	1	Lung NSC(6;2.07e-05)					ATTTCAGTTTCAAAACTGCCA	0.398		NaN											0	0	0	0.268233	0	43	55									
KCNN2	3781	broad.mit.edu	37	5	113698898	113698898	+	Silent	SNP	C	C	T			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr5:113698898C>T	uc003kqo.2	+	1	883	c.426C>T	c.(424-426)GGC>GGT	p.G142G		NM_021614	NP_067627	Q9H2S1	KCNN2_HUMAN	small conductance calcium-activated potassium	142	Helical; Name=Segment S1; (Potential).					integral to membrane	calmodulin binding|small conductance calcium-activated potassium channel activity			ovary(2)	2		all_cancers(142;2.86e-05)|all_epithelial(76;9.33e-06)|Prostate(80;0.00955)|Ovarian(225;0.0444)|Breast(839;0.159)|Lung NSC(810;0.174)|all_lung(232;0.206)		OV - Ovarian serous cystadenocarcinoma(64;1.89e-08)|Epithelial(69;2.04e-08)|all cancers(49;3.74e-06)|COAD - Colon adenocarcinoma(37;0.142)|Colorectal(14;0.195)		TCATCTTCGGCATGTTCGGCA	0.612		NaN											0	0	0	0.173368	0	35	2									
FAM193B	54540	broad.mit.edu	37	5	176958345	176958345	+	Missense_Mutation	SNP	C	C	T			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr5:176958345C>T	uc003mhs.3	-	7	2703	c.1114G>A	c.(1114-1116)GAG>AAG	p.E372K	FAM193B_uc003mht.2_Missense_Mutation_p.E31K|FAM193B_uc003mhu.2_Intron|FAM193B_uc003mhv.2_Missense_Mutation_p.E31K|FAM193B_uc003mhw.2_RNA	NM_019057	NP_061930	E9PET5	E9PET5_HUMAN	hypothetical protein LOC54540	391											0						ACTTTGGGCTCCGTGCTGTTG	0.657		NaN											0	0	0	0.184627	0	5	0									
RING1	6015	broad.mit.edu	37	6	33179090	33179090	+	Missense_Mutation	SNP	G	G	T			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr6:33179090G>T	uc003odk.2	+	5	805	c.611G>T	c.(610-612)CGT>CTT	p.R204L	RING1_uc011dqx.1_Missense_Mutation_p.R204L|RING1_uc003odl.2_Missense_Mutation_p.R175L	NM_002931	NP_002922	Q06587	RING1_HUMAN	ring finger protein 1	204	Necessary for transcriptional repression (By similarity).|Nuclear localization signal (Potential).				histone H2A monoubiquitination|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nuclear speck|PcG protein complex	protein binding|zinc ion binding			ovary(1)|skin(1)	2						AAGCGACCCCGTGGAGGGGGC	0.711		NaN											1	0	4.54149e-19	0.249174	4.99241e-19	21	38									
CDKN1A	1026	broad.mit.edu	37	6	36651906	36651906	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr6:36651906C>T	uc003omm.3	+	2	150	c.28C>T	c.(28-30)CAG>TAG	p.Q10*	CDKN1A_uc011dtq.1_Nonsense_Mutation_p.Q44*|CDKN1A_uc003oml.2_Nonsense_Mutation_p.Q10*|CDKN1A_uc003omn.2_Nonsense_Mutation_p.Q10*	NM_000389	NP_000380	P38936	CDN1A_HUMAN	cyclin-dependent kinase inhibitor 1A	10					cell cycle arrest|cellular response to extracellular stimulus|cellular response to ionizing radiation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|G2/M transition of mitotic cell cycle|induction of apoptosis by intracellular signals|negative regulation of cell growth|negative regulation of cell proliferation|positive regulation of fibroblast proliferation|positive regulation of reactive oxygen species metabolic process|Ras protein signal transduction|S phase of mitotic cell cycle|stress-induced premature senescence	cyclin-dependent protein kinase holoenzyme complex|cytosol|nucleoplasm|PCNA-p21 complex	cyclin-dependent protein kinase activating kinase activity|cyclin-dependent protein kinase inhibitor activity|metal ion binding			ovary(1)|breast(1)	2						GGATGTCCGTCAGAACCCATG	0.637		NaN							Multiple_Endocrine_Neoplasia_type_1				0	0	0	0.26419	0	21	15									
CCND3	896	broad.mit.edu	37	6	41909293	41909293	+	Missense_Mutation	SNP	A	A	C			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08			A	C	A	A		Valid	Somatic	Phase_I	WXS	RNASeq			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr6:41909293A>C	uc003orn.2	-	1	260	c.95T>G	c.(94-96)CTC>CGC	p.L32R	CCND3_uc003orp.2_Intron|CCND3_uc011duk.1_Intron|CCND3_uc011dum.1_Intron|CCND3_uc003orm.2_5'Flank|CCND3_uc003oro.2_Missense_Mutation_p.L32R|CCND3_uc011dul.1_Missense_Mutation_p.L32R	NM_001760	NP_001751	P30281	CCND3_HUMAN	cyclin D3 isoform 2	32	Cyclin N-terminal.				cell division|positive regulation of cyclin-dependent protein kinase activity|positive regulation of protein phosphorylation	cyclin-dependent protein kinase holoenzyme complex|cytoplasm|membrane|nucleus	protein kinase binding				0	Colorectal(47;0.121)		Epithelial(12;0.000178)|STAD - Stomach adenocarcinoma(11;0.000204)|Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)			CTCCAGGCGGAGCAGGCTCTG	0.552		NaN	T	IGH@	MM								0	0	0	0.248553	0	7	4									
MAD2L1BP	9587	broad.mit.edu	37	6	43608115	43608115	+	Missense_Mutation	SNP	G	G	C			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr6:43608115G>C	uc003ovv.2	+	3	706	c.670G>C	c.(670-672)GAT>CAT	p.D224H	MAD2L1BP_uc003ovu.2_Missense_Mutation_p.D256H	NM_014628	NP_055443	Q15013	MD2BP_HUMAN	MAD2L1 binding protein isoform 2	224					mitotic cell cycle checkpoint|regulation of exit from mitosis	cytoplasm|nucleus|spindle	protein binding				0	all_cancers(18;9.36e-06)|Lung NSC(15;0.00161)|all_lung(25;0.004)		all cancers(41;0.000351)|Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|STAD - Stomach adenocarcinoma(11;0.0826)|OV - Ovarian serous cystadenocarcinoma(102;0.167)			CTGTGGAGAAGATTGGTTTCG	0.567		NaN											0	0	0	0.163468	0	34	25									
TNFRSF21	27242	broad.mit.edu	37	6	47200581	47200581	+	Missense_Mutation	SNP	C	C	G			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr6:47200581C>G	uc003oyv.2	-	6	2321	c.1888G>C	c.(1888-1890)GAA>CAA	p.E630Q		NM_014452	NP_055267	O75509	TNR21_HUMAN	tumor necrosis factor receptor superfamily,	630	Cytoplasmic (Potential).				cellular lipid metabolic process	cytoplasm|integral to membrane	protein binding|receptor activity				0			Lung(136;0.189)			CCAATAATTTCGAATAGCCGG	0.493		NaN											0	0	0	0.139131	0	68	108									
DNAH11	8701	broad.mit.edu	37	7	21818711	21818711	+	Missense_Mutation	SNP	G	G	C			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr7:21818711G>C	uc003svc.2	+	58	9524	c.9493G>C	c.(9493-9495)GAG>CAG	p.E3165Q		NM_003777	NP_003768	Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	3165	Stalk (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(8)|large_intestine(3)|pancreas(3)|central_nervous_system(1)	15						CGCTGATGCTGAGGAGCGAAA	0.463		NaN							Kartagener_syndrome				0	0	0	0.09319	0	12	11									
ZNF479	90827	broad.mit.edu	37	7	57188745	57188745	+	Missense_Mutation	SNP	T	T	C			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr7:57188745T>C	uc010kzo.2	-	5	648	c.377A>G	c.(376-378)AAA>AGA	p.K126R		NM_033273	NP_150376	Q96JC4	ZN479_HUMAN	zinc finger protein 479	126					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)|skin(1)	4			GBM - Glioblastoma multiforme(1;9.18e-12)			ACAGCATTTTTTAAATTGTAA	0.368		NaN											0	0	0	0.09319	0	10	105									
LIMK1	3984	broad.mit.edu	37	7	73535372	73535372	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr7:73535372G>A	uc003uaa.1	+	15	1939	c.1774G>A	c.(1774-1776)GAG>AAG	p.E592K	RFC2_uc011kfa.1_Intron|LIMK1_uc010lbl.1_RNA|LIMK1_uc003uab.2_Missense_Mutation_p.E558K	NM_002314	NP_002305	P53667	LIMK1_HUMAN	LIM domain kinase 1	592	Protein kinase.				actin cytoskeleton organization|axon guidance|negative regulation of ubiquitin-protein ligase activity|positive regulation of actin filament bundle assembly|positive regulation of axon extension|Rho protein signal transduction	cytosol|growth cone|nucleus	ATP binding|heat shock protein binding|protein serine/threonine kinase activity|zinc ion binding			stomach(2)|ovary(1)	3		Lung NSC(55;0.137)				TCTGGACCCCGAGAAGAGGTG	0.672		NaN											0	0	0	0.139131	0	51	76									
CFTR	1080	broad.mit.edu	37	7	117232105	117232105	+	Silent	SNP	G	G	A			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr7:117232105G>A	uc003vjd.2	+	14	2016	c.1884G>A	c.(1882-1884)GGG>GGA	p.G628G	CFTR_uc011knq.1_Silent_p.G34G	NM_000492	NP_000483	P13569	CFTR_HUMAN	cystic fibrosis transmembrane conductance	628	Cytoplasmic (Potential).|ABC transporter 1.		G -> R (in CF).		respiratory gaseous exchange	apical plasma membrane|basolateral plasma membrane|chloride channel complex|early endosome membrane	ATP binding|ATP-binding and phosphorylation-dependent chloride channel activity|channel-conductance-controlling ATPase activity|chloride channel regulator activity|enzyme binding|PDZ domain binding			central_nervous_system(2)|skin(2)|ovary(1)	5	Lung NSC(10;0.00148)|all_lung(10;0.00171)		STAD - Stomach adenocarcinoma(10;0.000534)		Bumetanide(DB00887)|Glibenclamide(DB01016)	ATTTTTATGGGACATTTTCAG	0.343		NaN							Cystic_Fibrosis				0	0	0	0.139131	0	48	62									
TACC1	6867	broad.mit.edu	37	8	38677716	38677716	+	Silent	SNP	C	C	G	rs61734982	byFrequency	TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr8:38677716C>G	uc010lwp.2	+	3	1333	c.954C>G	c.(952-954)CTC>CTG	p.L318L	TACC1_uc011lby.1_Silent_p.L123L|TACC1_uc003xma.2_Intron|TACC1_uc003xlz.2_Silent_p.L123L|TACC1_uc003xmc.3_Silent_p.L123L|TACC1_uc011lbz.1_Silent_p.L334L|TACC1_uc003xmb.3_Silent_p.L273L|TACC1_uc003xme.1_Intron|TACC1_uc003xmd.1_Intron|TACC1_uc010lwo.1_Intron|TACC1_uc003xmf.3_Intron|TACC1_uc011lca.1_Silent_p.L318L|TACC1_uc011lcb.1_Silent_p.L123L|TACC1_uc011lcc.1_Silent_p.L123L|TACC1_uc011lcd.1_RNA|TACC1_uc003xmh.3_Silent_p.L123L|TACC1_uc010lwq.2_Silent_p.L123L	NM_006283	NP_006274	O75410	TACC1_HUMAN	transforming, acidic coiled-coil containing	318	Interaction with YEATS4.				cell cycle|cell division	intermediate filament cytoskeleton|microtubule organizing center|nucleus	protein binding			ovary(1)	1		all_lung(54;0.00292)|Lung NSC(58;0.0115)|Hepatocellular(245;0.065)	LUSC - Lung squamous cell carcinoma(45;1.7e-09)|COAD - Colon adenocarcinoma(9;0.235)			GCTCACCTCTCAAGCTTGAGT	0.527		NaN											0	0	0	0.301197	0	47	43									
DCAF4L2	138009	broad.mit.edu	37	8	88886086	88886086	+	Missense_Mutation	SNP	T	T	A			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr8:88886086T>A	uc003ydz.2	-	1	211	c.114A>T	c.(112-114)AGA>AGT	p.R38S		NM_152418	NP_689631	Q8NA75	DC4L2_HUMAN	WD repeat domain 21C	38										ovary(1)	1						AGTTGGCGAATCTGAGGAAAC	0.522		NaN											0	0	0	0.132662	0	15	58									
MPDZ	8777	broad.mit.edu	37	9	13137991	13137991	+	Missense_Mutation	SNP	C	C	T			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr9:13137991C>T	uc010mia.1	-	28	4222	c.4165G>A	c.(4165-4167)GAT>AAT	p.D1389N	MPDZ_uc003zky.3_5'Flank|MPDZ_uc010mib.2_Missense_Mutation_p.D94N|MPDZ_uc010mhx.2_Missense_Mutation_p.D211N|MPDZ_uc011lmm.1_Missense_Mutation_p.D248N|MPDZ_uc003zkz.3_Missense_Mutation_p.D82N|MPDZ_uc010mhy.2_Missense_Mutation_p.D1389N|MPDZ_uc010mhz.2_Missense_Mutation_p.D1356N|MPDZ_uc011lmn.1_Missense_Mutation_p.D1356N|MPDZ_uc003zlb.3_Missense_Mutation_p.D1389N	NM_003829	NP_003820	O75970	MPDZ_HUMAN	multiple PDZ domain protein	1389	PDZ 8.				interspecies interaction between organisms	apical plasma membrane|dendrite|postsynaptic density|postsynaptic membrane|synaptosome|tight junction	protein C-terminus binding			ovary(5)|central_nervous_system(1)	6				GBM - Glioblastoma multiforme(50;2.03e-06)		AATCGACCATCTTTTCCTGCA	0.408		NaN											0	0	0	0.144211	0	31	19									
MPDZ	8777	broad.mit.edu	37	9	13137996	13137996	+	Missense_Mutation	SNP	C	C	T			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr9:13137996C>T	uc010mia.1	-	28	4217	c.4160G>A	c.(4159-4161)GGA>GAA	p.G1387E	MPDZ_uc003zky.3_5'Flank|MPDZ_uc010mib.2_Missense_Mutation_p.G92E|MPDZ_uc010mhx.2_Missense_Mutation_p.G209E|MPDZ_uc011lmm.1_Missense_Mutation_p.G246E|MPDZ_uc003zkz.3_Missense_Mutation_p.G80E|MPDZ_uc010mhy.2_Missense_Mutation_p.G1387E|MPDZ_uc010mhz.2_Missense_Mutation_p.G1354E|MPDZ_uc011lmn.1_Missense_Mutation_p.G1354E|MPDZ_uc003zlb.3_Missense_Mutation_p.G1387E	NM_003829	NP_003820	O75970	MPDZ_HUMAN	multiple PDZ domain protein	1387	PDZ 8.				interspecies interaction between organisms	apical plasma membrane|dendrite|postsynaptic density|postsynaptic membrane|synaptosome|tight junction	protein C-terminus binding			ovary(5)|central_nervous_system(1)	6				GBM - Glioblastoma multiforme(50;2.03e-06)		ACCATCTTTTCCTGCAGCTCC	0.408		NaN											0	0	0	0.116897	0	30	21									
IFNA14	3448	broad.mit.edu	37	9	21239749	21239749	+	Silent	SNP	G	G	T			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr9:21239749G>T	uc010mis.2	-	1	230	c.186C>A	c.(184-186)CCC>CCA	p.P62P	IFNA14_uc003zoo.1_RNA	NM_002172	NP_002163	P01570	IFN14_HUMAN	interferon, alpha 14 precursor	62					blood coagulation|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	extracellular space	cytokine activity|cytokine receptor binding				0				Lung(24;2.12e-22)|LUSC - Lung squamous cell carcinoma(38;1.4e-13)		ATTCCTCCTGGGGAAATTCAA	0.473		NaN											1	0	3.07184e-27	0.139131	3.42543e-27	67	173									
RUSC2	9853	broad.mit.edu	37	9	35560350	35560350	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr9:35560350G>A	uc003zww.2	+	10	3968	c.3713G>A	c.(3712-3714)GGA>GAA	p.G1238E	RUSC2_uc010mkq.2_RNA|RUSC2_uc003zwx.3_Missense_Mutation_p.G1238E	NM_014806	NP_055621	Q8N2Y8	RUSC2_HUMAN	RUN and SH3 domain containing 2	1238						cytosol				ovary(1)	1			Lung(28;0.000837)|LUSC - Lung squamous cell carcinoma(32;0.00109)|STAD - Stomach adenocarcinoma(86;0.194)			TCagaaggtggagaagaggaa	0.557		NaN											0	0	0	0.058154	0	9	18									
SMC2	10592	broad.mit.edu	37	9	106880491	106880491	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr9:106880491G>A	uc004bbv.2	+	15	2119	c.1831G>A	c.(1831-1833)GAA>AAA	p.E611K	SMC2_uc004bbu.1_Missense_Mutation_p.E611K|SMC2_uc004bbw.2_Missense_Mutation_p.E611K|SMC2_uc011lvl.1_Missense_Mutation_p.E611K|SMC2_uc004bbx.2_Missense_Mutation_p.E611K	NM_001042551	NP_001036016	O95347	SMC2_HUMAN	structural maintenance of chromosomes 2	611	Flexible hinge.				cell division|mitotic chromosome condensation|symbiosis, encompassing mutualism through parasitism	condensin complex|cytoplasm|nuclear chromosome	ATP binding|protein heterodimerization activity			ovary(4)|skin(2)|haematopoietic_and_lymphoid_tissue(1)|lung(1)|breast(1)	9						TTCCTTGGTTGAATATAAACC	0.388		NaN											0	0	0	0.131918	0	43	6									
C9orf5	23731	broad.mit.edu	37	9	111853251	111853251	+	Missense_Mutation	SNP	C	C	A			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr9:111853251C>A	uc004bdt.3	-	5	1133	c.1101G>T	c.(1099-1101)CAG>CAT	p.Q367H	C9orf5_uc004bds.3_RNA|C9orf5_uc004bdr.3_Missense_Mutation_p.Q367H	NM_032012	NP_114401	Q9H330	CI005_HUMAN	hypothetical protein LOC23731	367	Helical; (Potential).					integral to membrane				central_nervous_system(1)	1		Myeloproliferative disorder(63;0.204)		OV - Ovarian serous cystadenocarcinoma(323;3.08e-05)|STAD - Stomach adenocarcinoma(157;0.0823)		TCAACCAGATCTGCATGACGA	0.443		NaN											1	0	7.26314e-15	0.125774	7.81796e-15	27	7									
CSF2RA	1438	broad.mit.edu	37	X	1409371	1409371	+	Silent	SNP	C	C	T			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chrX:1409371C>T	uc010nct.2	+	8	937	c.615C>T	c.(613-615)TTC>TTT	p.F205F	CSF2RA_uc011mhb.1_Silent_p.F205F|CSF2RA_uc004cpq.2_Silent_p.F205F|CSF2RA_uc004cpn.2_Silent_p.F205F|CSF2RA_uc004cpo.2_Silent_p.F205F|CSF2RA_uc010ncu.2_RNA|CSF2RA_uc011mhc.1_Silent_p.F72F|CSF2RA_uc004cpp.2_Silent_p.F205F|CSF2RA_uc010ncv.2_Silent_p.F205F|CSF2RA_uc004cpr.2_Silent_p.F205F	NM_001161529	NP_001155001	P15509	CSF2R_HUMAN	colony stimulating factor 2 receptor alpha chain	205	Extracellular (Potential).					extracellular region|integral to plasma membrane	cytokine receptor activity			ovary(2)	2		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)			Sargramostim(DB00020)	GCATCCAATTCTTTGATTCAC	0.383		NaN											0	0	0	0.139131	0	129	179									
NHS	4810	broad.mit.edu	37	X	17744787	17744787	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chrX:17744787G>A	uc004cxx.2	+	6	2836	c.2498G>A	c.(2497-2499)CGT>CAT	p.R833H	NHS_uc011mix.1_Missense_Mutation_p.R854H|NHS_uc004cxy.2_Missense_Mutation_p.R677H|NHS_uc004cxz.2_Missense_Mutation_p.R656H|NHS_uc004cya.2_Missense_Mutation_p.R556H	NM_198270	NP_938011	Q6T4R5	NHS_HUMAN	Nance-Horan syndrome protein isoform 1	833						nucleus				skin(3)|ovary(2)|breast(1)|central_nervous_system(1)	7	Hepatocellular(33;0.183)					CCACCTAAACGTAGCTCATCA	0.488		NaN											0	0	0	0.139131	0	89	7									
CCNB3	85417	broad.mit.edu	37	X	50089666	50089666	+	Missense_Mutation	SNP	C	C	T			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chrX:50089666C>T	uc004dox.3	+	10	3968	c.3670C>T	c.(3670-3672)CGT>TGT	p.R1224C	CCNB3_uc004doy.2_Missense_Mutation_p.R1224C|CCNB3_uc004doz.2_Missense_Mutation_p.R120C|CCNB3_uc010njq.2_Missense_Mutation_p.R116C|CCNB3_uc004dpa.2_Missense_Mutation_p.R63C	NM_033031	NP_149020	Q8WWL7	CCNB3_HUMAN	cyclin B3 isoform 3	1224					cell division|meiosis|regulation of cyclin-dependent protein kinase activity|regulation of G2/M transition of mitotic cell cycle	nucleus	protein kinase binding			ovary(4)|lung(3)|large_intestine(1)|pancreas(1)	9	Ovarian(276;0.236)					CAACTCACCTCGTGTGGATGA	0.463		NaN											0	0	0	0.139131	0	44	3									
SLC16A2	6567	broad.mit.edu	37	X	73751256	73751256	+	Silent	SNP	C	C	T			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chrX:73751256C>T	uc004ebt.2	+	6	1876	c.1710C>T	c.(1708-1710)TTC>TTT	p.F570F	SLC16A2_uc010nlr.1_3'UTR	NM_006517	NP_006508	P36021	MOT8_HUMAN	solute carrier family 16, member 2	496	Helical; (Potential).					integral to plasma membrane|membrane fraction	monocarboxylic acid transmembrane transporter activity|symporter activity			breast(2)|ovary(1)	3					Pyruvic acid(DB00119)	TCCTCTTCTTCGTCCCTCTGA	0.532		NaN											0	0	0	0.139131	0	51	6									
FLNA	2316	broad.mit.edu	37	X	153593318	153593318	+	Missense_Mutation	SNP	C	C	T			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chrX:153593318C>T	uc004fkk.2	-	12	1948	c.1699G>A	c.(1699-1701)GAA>AAA	p.E567K	FLNA_uc010nuu.1_Missense_Mutation_p.E567K	NM_001110556	NP_001104026	P21333	FLNA_HUMAN	filamin A, alpha isoform 2	567	Filamin 3.				actin crosslink formation|actin cytoskeleton reorganization|cell junction assembly|cytoplasmic sequestering of protein|establishment of protein localization|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|negative regulation of protein catabolic process|negative regulation of sequence-specific DNA binding transcription factor activity|platelet activation|platelet degranulation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of transcription factor import into nucleus|protein localization at cell surface|protein stabilization|receptor clustering	cell cortex|cytosol|extracellular region|nucleus|plasma membrane	actin filament binding|Fc-gamma receptor I complex binding|glycoprotein binding|GTP-Ral binding|protein homodimerization activity|Rac GTPase binding|signal transducer activity|transcription factor binding			breast(6)	6	all_cancers(53;3.7e-16)|all_epithelial(53;2.97e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					ACCTTCACTTCGAAGGGACTG	0.632		NaN											0	0	0	0.268233	0	42	42									
PARD3	56288	broad.mit.edu	37	10	34630676	34630689	+	Frame_Shift_Del	DEL	ACCTGTCATCTTCT	ACCTGTCATCTTCT	-			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr10:34630676_34630689delACCTGTCATCTTCT	uc010qej.1	-	16	2283_2296	c.2283_2296delAGAAGATGACAGGT	c.(2281-2298)ATAGAAGATGACAGGTTGfs	p.I761fs	PARD3_uc010qek.1_Frame_Shift_Del_p.I758fs|PARD3_uc010qel.1_Frame_Shift_Del_p.I761fs|PARD3_uc010qem.1_Frame_Shift_Del_p.I745fs|PARD3_uc010qen.1_Frame_Shift_Del_p.I745fs|PARD3_uc010qeo.1_Frame_Shift_Del_p.I745fs|PARD3_uc010qep.1_Frame_Shift_Del_p.I701fs|PARD3_uc010qeq.1_Frame_Shift_Del_p.I701fs|PARD3_uc001ixo.1_Frame_Shift_Del_p.I475fs|PARD3_uc001ixp.1_Frame_Shift_Del_p.I623fs|PARD3_uc001ixq.1_Frame_Shift_Del_p.I745fs|PARD3_uc001ixr.1_Frame_Shift_Del_p.I758fs|PARD3_uc001ixt.1_Frame_Shift_Del_p.I579fs|PARD3_uc001ixu.1_Frame_Shift_Del_p.I704fs|PARD3_uc001ixs.1_Frame_Shift_Del_p.I414fs	NM_019619	NP_062565	Q8TEW0	PARD3_HUMAN	partitioning-defective protein 3 homolog	761_766	Interacts with PRKCZ (By similarity).				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|asymmetric cell division|axonogenesis|cell cycle|establishment of epithelial cell polarity|protein complex assembly|protein targeting to membrane|tight junction assembly	cell cortex|cytoskeleton|cytosol|endomembrane system|tight junction	phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-4,5-bisphosphate binding|protein binding			ovary(1)	1		Breast(68;0.0707)				AGCACTGGCAACCTGTCATCTTCTATAATGACAG	0.481		NaN											NaN	NaN	NaN	NaN	NaN	32	83	---	---							
LRDD	55367	broad.mit.edu	37	11	800588	800596	+	In_Frame_Del	DEL	CGCCCTCGA	CGCCCTCGA	-	rs151136652		TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr11:800588_800596delCGCCCTCGA	uc001lro.1	-	12	2130_2138	c.1988_1996delTCGAGGGCG	c.(1987-1998)TTCGAGGGCGAA>TAA	p.663_666FEGE>*	SLC25A22_uc009yci.2_5'Flank|SLC25A22_uc001lrj.2_5'Flank|LRDD_uc009yck.1_RNA|LRDD_uc001lrk.1_In_Frame_Del_p.663_666FEGE>*|LRDD_uc001lrl.1_In_Frame_Del_p.506_509FEGE>*|LRDD_uc001lrm.1_In_Frame_Del_p.350_353FEGE>*|LRDD_uc001lrn.1_In_Frame_Del_p.506_509FEGE>*|LRDD_uc001lrp.1_In_Frame_Del_p.325_328FEGE>*	NM_145886	NP_665893	Q9HB75	PIDD_HUMAN	leucine rich repeat and death domain containing	663_666					apoptosis|signal transduction	cytoplasm|nucleus	death receptor binding				0		all_cancers(49;1.13e-08)|all_epithelial(84;2.95e-05)|Breast(177;0.000286)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.159)|all_lung(207;0.198)		all cancers(45;1.45e-25)|Epithelial(43;1.17e-24)|OV - Ovarian serous cystadenocarcinoma(40;6.76e-19)|BRCA - Breast invasive adenocarcinoma(625;4.23e-05)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)		AAGAACTCTTCGCCCTCGAACATCTCCAC	0.684		NaN											NaN	NaN	NaN	NaN	NaN	13	19	---	---							
GSPT1	2935	broad.mit.edu	37	16	12009530	12009531	+	In_Frame_Ins	INS	-	-	CCG	rs71408216		TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr16:12009530_12009531insCCG	uc002dbt.2	-	1	295_296	c.47_48insCGG	c.(46-48)GGG>GGCGGG	p.16_16G>GG	GSPT1_uc002dbu.2_In_Frame_Ins_p.16_16G>GG|GSPT1_uc010bux.2_Intron	NM_002094	NP_002085	P15170	ERF3A_HUMAN	G1 to S phase transition 1 isoform 1	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					G1/S transition of mitotic cell cycle|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|protein methylation	intracellular	GTP binding|GTPase activity|protein binding|translation release factor activity			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3						cgctgctgctcccgccgccgcc	0.332		NaN											NaN	NaN	NaN	NaN	NaN	5	2	---	---							
CYP7A1	1581	broad.mit.edu	37	8	59410812	59410812	+	Frame_Shift_Del	DEL	T	T	-			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr8:59410812delT	uc003xtm.3	-	2	360	c.297delA	c.(295-297)AAAfs	p.K99fs		NM_000780	NP_000771	P22680	CP7A1_HUMAN	cytochrome P450, family 7, subfamily A,	99					bile acid biosynthetic process|cellular lipid metabolic process|cellular response to cholesterol|cellular response to glucose stimulus|cholesterol catabolic process|cholesterol homeostasis|regulation of bile acid biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	cholesterol 7-alpha-monooxygenase activity|electron carrier activity|heme binding			ovary(1)	1		all_lung(136;0.0271)|Lung NSC(129;0.0351)|all_epithelial(80;0.0554)				CAAAGTGAAATTTTTTCCAAT	0.323		NaN							Neonatal_Giant_Cell_Hepatitis				NaN	NaN	NaN	NaN	NaN	29	133	---	---