Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	isArtifactMode	oxoGCut	pox	pox_cutoff	qox	t_alt_count	t_ref_count	validation_alt_allele	validation_tumor_sample							
PRDM16	63976	broad.mit.edu	37	1	3319489	3319489	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:3319489G>C	uc001akf.2	+	6	891	c.811G>C	c.(811-813)GAG>CAG	p.E271Q	PRDM16_uc001akc.2_Missense_Mutation_p.E271Q|PRDM16_uc001akd.2_Missense_Mutation_p.E271Q|PRDM16_uc001ake.2_Missense_Mutation_p.E271Q|PRDM16_uc009vlh.2_5'UTR	NM_022114	NP_071397	Q9HAZ2	PRD16_HUMAN	PR domain containing 16 isoform 1	271					brown fat cell differentiation|negative regulation of granulocyte differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transforming growth factor beta receptor signaling pathway|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|regulation of cellular respiration|transcription, DNA-dependent	transcriptional repressor complex	protein binding|sequence-specific DNA binding|transcription coactivator activity|zinc ion binding			lung(3)|ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	7	all_cancers(77;0.00208)|all_epithelial(69;0.000732)|Ovarian(185;0.0634)|Lung NSC(156;0.109)|all_lung(157;0.111)	all_epithelial(116;2.03e-21)|all_lung(118;7.55e-09)|Lung NSC(185;1.28e-06)|Breast(487;0.000792)|Renal(390;0.00137)|Hepatocellular(190;0.00515)|Myeloproliferative disorder(586;0.0267)|Ovarian(437;0.0365)|Lung SC(97;0.114)|Medulloblastoma(700;0.134)		Epithelial(90;5.59e-35)|OV - Ovarian serous cystadenocarcinoma(86;1.99e-20)|GBM - Glioblastoma multiforme(42;3.72e-11)|Colorectal(212;0.000425)|BRCA - Breast invasive adenocarcinoma(365;0.000946)|COAD - Colon adenocarcinoma(227;0.000968)|Kidney(185;0.00155)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0175)|Lung(427;0.137)		GCTCAAGCCCGAGGGCCTTGG	0.622		NaN	T	EVI1	MDS|AML								0	0	0	0.007413	0	15	55									
CHD5	26038	broad.mit.edu	37	1	6173059	6173059	+	Splice_Site	SNP	C	C	G			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:6173059C>G	uc001amb.1	-	34	5013	c.4913_splice	c.e34-1	p.E1638_splice	CHD5_uc001alz.1_Splice_Site_p.E495_splice|CHD5_uc001ama.1_Splice_Site	NM_015557	NP_056372	Q8TDI0	CHD5_HUMAN	chromodomain helicase DNA binding protein 5						chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|DNA binding|zinc ion binding			central_nervous_system(3)|breast(3)|ovary(2)|upper_aerodigestive_tract(1)|lung(1)|skin(1)|pancreas(1)	12	Ovarian(185;0.0634)	all_cancers(23;5.36e-32)|all_epithelial(116;2.32e-17)|all_neural(13;3.68e-06)|all_lung(118;3.94e-06)|all_hematologic(16;2.39e-05)|Lung NSC(185;5.33e-05)|Acute lymphoblastic leukemia(12;0.000372)|Glioma(11;0.00127)|Renal(390;0.00188)|Colorectal(325;0.00342)|Breast(487;0.00373)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.15)		Epithelial(90;3.08e-37)|GBM - Glioblastoma multiforme(13;1.36e-31)|OV - Ovarian serous cystadenocarcinoma(86;7.7e-19)|Colorectal(212;9.97e-08)|COAD - Colon adenocarcinoma(227;1.07e-05)|Kidney(185;6.16e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.00109)|BRCA - Breast invasive adenocarcinoma(365;0.0012)|STAD - Stomach adenocarcinoma(132;0.00346)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.193)		AGCACCTCCTCTGCAAGAAAA	0.562		NaN											0	0	0	0.00245	0	15	66									
ZBTB48	3104	broad.mit.edu	37	1	6649195	6649195	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:6649195G>A	uc009vmc.1	+	11	2113	c.1990G>A	c.(1990-1992)GAG>AAG	p.E664K	ZBTB48_uc001anx.2_Missense_Mutation_p.E664K|ZBTB48_uc009vmd.1_Missense_Mutation_p.E664K|ZBTB48_uc001any.1_Missense_Mutation_p.E302K	NM_005341	NP_005332	P10074	ZBT48_HUMAN	zinc finger and BTB domain containing 48	664						cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0	Ovarian(185;0.0212)|all_lung(157;0.154)	all_cancers(23;7.39e-28)|all_epithelial(116;1.76e-17)|all_lung(118;2.27e-05)|Lung NSC(185;9.97e-05)|Renal(390;0.00188)|Breast(487;0.00289)|Colorectal(325;0.00342)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.156)		Colorectal(212;1.35e-07)|COAD - Colon adenocarcinoma(227;1.36e-05)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000911)|BRCA - Breast invasive adenocarcinoma(304;0.00109)|STAD - Stomach adenocarcinoma(132;0.017)|READ - Rectum adenocarcinoma(331;0.0642)		GTGTGCAGAGGAGAGCTTCAC	0.667		NaN											0	0	0	0.00245	0	15	71									
CAMTA1	23261	broad.mit.edu	37	1	6885189	6885189	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:6885189C>G	uc001aoi.2	+	3	360	c.153C>G	c.(151-153)ATC>ATG	p.I51M	CAMTA1_uc001aoh.2_RNA	NM_015215	NP_056030	Q9Y6Y1	CMTA1_HUMAN	calmodulin-binding transcription activator 1	51					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	calmodulin binding			ovary(5)|central_nervous_system(2)|breast(1)|pancreas(1)	9	Ovarian(185;0.0634)	all_epithelial(116;8.38e-23)|all_lung(118;5.87e-07)|Lung NSC(185;3.43e-06)|Renal(390;0.000219)|Breast(487;0.000307)|Colorectal(325;0.000615)|Hepatocellular(190;0.0088)|Myeloproliferative disorder(586;0.0303)|Ovarian(437;0.0388)		UCEC - Uterine corpus endometrioid carcinoma (279;0.101)|Colorectal(212;1.33e-05)|COAD - Colon adenocarcinoma(227;0.000235)|BRCA - Breast invasive adenocarcinoma(304;0.000864)|Kidney(185;0.00244)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0179)|READ - Rectum adenocarcinoma(331;0.133)		ATGTAAAAATCTTTTTACCGA	0.323		NaN											0	0	0	0.005443	0	27	97									
UTS2	10911	broad.mit.edu	37	1	7907829	7907829	+	Silent	SNP	G	G	C			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:7907829G>C	uc001aor.2	-	4	413	c.372C>G	c.(370-372)GTC>GTG	p.V124V	UTS2_uc001aoq.2_Intron|UTS2_uc001aos.2_Silent_p.V139V	NM_006786	NP_006777	O95399	UTS2_HUMAN	urotensin 2 isoform b preproprotein	124					muscle contraction|regulation of blood pressure|synaptic transmission	extracellular space	hormone activity				0	Ovarian(185;0.0634)|all_lung(157;0.178)	all_epithelial(116;1.38e-20)|all_lung(118;1.29e-06)|Lung NSC(185;7.5e-06)|Renal(390;0.000147)|Breast(348;0.00086)|Colorectal(325;0.000959)|Hepatocellular(190;0.00825)|Ovarian(437;0.0253)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;9.26e-71)|GBM - Glioblastoma multiforme(8;5.15e-36)|Colorectal(212;1.27e-07)|COAD - Colon adenocarcinoma(227;1.33e-05)|Kidney(185;4.89e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000386)|KIRC - Kidney renal clear cell carcinoma(229;0.000894)|STAD - Stomach adenocarcinoma(132;0.000951)|READ - Rectum adenocarcinoma(331;0.0642)		TTTCACTTCAGACACAGTATT	0.373		NaN											0	0	0	0.01441	0	47	266									
SRM	6723	broad.mit.edu	37	1	11115915	11115915	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:11115915C>T	uc001arz.1	-	6	779	c.688G>A	c.(688-690)GTG>ATG	p.V230M	SRM_uc001ary.1_Missense_Mutation_p.V91M	NM_003132	NP_003123	P19623	SPEE_HUMAN	spermidine synthase	230					spermidine biosynthetic process	cytosol	protein homodimerization activity|spermidine synthase activity				0	Ovarian(185;0.249)	Lung NSC(185;1.74e-05)|all_lung(284;2.05e-05)|Renal(390;0.000147)|Colorectal(325;0.00205)|Breast(348;0.00262)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)	STAD - Stomach adenocarcinoma(5;0.228)	UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.14e-07)|COAD - Colon adenocarcinoma(227;7.11e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000294)|Kidney(185;0.000728)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|READ - Rectum adenocarcinoma(331;0.0487)|STAD - Stomach adenocarcinoma(313;0.192)	S-Adenosylmethionine(DB00118)|Spermine(DB00127)	TAGGCCACCACGGGGAACAGG	0.642		NaN											0	0	0	0.000602	0	3	24									
CROCC	9696	broad.mit.edu	37	1	17249254	17249254	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:17249254G>A	uc001azt.2	+	2	226	c.157G>A	c.(157-159)GAG>AAG	p.E53K	CROCC_uc009voy.1_Intron|CROCC_uc009voz.1_5'UTR	NM_014675	NP_055490	Q5TZA2	CROCC_HUMAN	ciliary rootlet coiled-coil	53					cell cycle|cell projection organization|centrosome organization|protein localization	actin cytoskeleton|centriole|ciliary rootlet|plasma membrane	kinesin binding|structural molecule activity			ovary(2)|breast(2)|central_nervous_system(1)	5		Colorectal(325;3.46e-05)|Breast(348;0.000162)|Lung NSC(340;0.000174)|all_lung(284;0.000234)|Renal(390;0.000518)|Ovarian(437;0.00669)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.63e-06)|COAD - Colon adenocarcinoma(227;1.07e-05)|Kidney(64;0.000163)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.181)		CCTTATCAGGGAGATTGTCAC	0.622		NaN											0	0	0	0.003755	0	35	109									
UBR4	23352	broad.mit.edu	37	1	19487565	19487565	+	Missense_Mutation	SNP	A	A	G			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:19487565A>G	uc001bbi.2	-	38	5256	c.5252T>C	c.(5251-5253)ATT>ACT	p.I1751T	UBR4_uc001bbm.1_Missense_Mutation_p.I962T	NM_020765	NP_065816	Q5T4S7	UBR4_HUMAN	retinoblastoma-associated factor 600	1751					interspecies interaction between organisms	cytoplasm|cytoskeleton|integral to membrane|nucleus	calmodulin binding|ubiquitin-protein ligase activity|zinc ion binding			kidney(10)|ovary(7)|breast(4)|pancreas(2)|skin(2)	25		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000328)|Lung NSC(340;0.000406)|Breast(348;0.000814)|Ovarian(437;0.00774)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00674)|BRCA - Breast invasive adenocarcinoma(304;5.43e-05)|Kidney(64;0.000337)|KIRC - Kidney renal clear cell carcinoma(64;0.00426)|STAD - Stomach adenocarcinoma(196;0.00715)|READ - Rectum adenocarcinoma(331;0.0816)		ACTCTCTGAAATCCTGGGTTC	0.517		NaN											0	0	0	0.001168	0	6	92									
AKR7L	246181	broad.mit.edu	37	1	19595155	19595155	+	Nonsense_Mutation	SNP	C	C	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:19595155C>A	uc010ocx.1	-	7	745	c.745G>T	c.(745-747)GAG>TAG	p.E249*	AKR7L_uc010ocy.1_Missense_Mutation_p.G183V	NM_201252	NP_957704			aflatoxin B1 aldehyde reductase 3 isoform 1												0						AGGGCCTTCTCCACCAGGGCA	0.632		NaN											1	0	2.32078e-09	0.003163	2.39697e-09	14	86									
RNF186	54546	broad.mit.edu	37	1	20141360	20141360	+	Missense_Mutation	SNP	A	A	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:20141360A>T	uc001bcr.2	-	1	412	c.235T>A	c.(235-237)TCC>ACC	p.S79T		NM_019062	NP_061935	Q9NXI6	RN186_HUMAN	ring finger protein 186	79	RING-type.					integral to membrane	zinc ion binding				0		Colorectal(325;0.000147)|Renal(390;0.000469)|all_lung(284;0.00459)|Lung NSC(340;0.00475)|Breast(348;0.00526)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0439)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|COAD - Colon adenocarcinoma(152;1.07e-05)|BRCA - Breast invasive adenocarcinoma(304;7.77e-05)|Kidney(64;0.000162)|GBM - Glioblastoma multiforme(114;0.00036)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)		CAGGTGATGGACCAGGTGTTG	0.692		NaN											0	0	0	0.007835	0	38	26									
EPHA8	2046	broad.mit.edu	37	1	22924702	22924702	+	Silent	SNP	G	G	C			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:22924702G>C	uc001bfx.1	+	12	2300	c.2175G>C	c.(2173-2175)CTG>CTC	p.L725L		NM_020526	NP_065387	P29322	EPHA8_HUMAN	ephrin receptor EphA8 isoform 1 precursor	725	Cytoplasmic (Potential).|Protein kinase.					integral to plasma membrane	ATP binding|ephrin receptor activity			central_nervous_system(5)|breast(3)|lung(2)|large_intestine(1)|stomach(1)|skin(1)	13		Colorectal(325;3.46e-05)|Lung NSC(340;6.55e-05)|all_lung(284;9.87e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;7.29e-27)|Colorectal(126;1.61e-07)|COAD - Colon adenocarcinoma(152;1.14e-05)|GBM - Glioblastoma multiforme(114;1.74e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000554)|KIRC - Kidney renal clear cell carcinoma(1967;0.00272)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.199)		ACACCTTCCTGAGGGTGCGTG	0.627		NaN											0	0	0	0.005443	0	23	121									
TCEA3	6920	broad.mit.edu	37	1	23713897	23713897	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:23713897C>T	uc001bgx.1	-	9	970	c.835G>A	c.(835-837)GAA>AAA	p.E279K	TCEA3_uc009vqm.1_Missense_Mutation_p.E48K	NM_003196	NP_003187	O75764	TCEA3_HUMAN	transcription elongation factor A (SII), 3	279	TFIIS central.				regulation of transcription elongation, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription elongation, DNA-dependent	nucleus	DNA binding|translation elongation factor activity|zinc ion binding				0		Colorectal(325;3.46e-05)|Lung NSC(340;4.16e-05)|all_lung(284;6.68e-05)|Renal(390;0.000219)|Breast(348;0.00262)|Ovarian(437;0.0054)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;1.6e-25)|Colorectal(126;8.32e-08)|COAD - Colon adenocarcinoma(152;4.29e-06)|GBM - Glioblastoma multiforme(114;9e-05)|BRCA - Breast invasive adenocarcinoma(304;0.00112)|KIRC - Kidney renal clear cell carcinoma(1967;0.00424)|STAD - Stomach adenocarcinoma(196;0.0145)|READ - Rectum adenocarcinoma(331;0.0686)|Lung(427;0.0963)|LUSC - Lung squamous cell carcinoma(448;0.198)		TCCCTCAGTTCATCACTGGCC	0.557		NaN											0	0	0	0.00499	0	17	11									
E2F2	1870	broad.mit.edu	37	1	23848342	23848342	+	Missense_Mutation	SNP	T	T	C			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:23848342T>C	uc001bhe.1	-	3	993	c.565A>G	c.(565-567)AAC>GAC	p.N189D		NM_004091	NP_004082	Q14209	E2F2_HUMAN	E2F transcription factor 2	189	DEF box.|Potential.				G1 phase of mitotic cell cycle|transcription initiation from RNA polymerase II promoter	transcription factor complex	DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding			ovary(2)|skin(2)	4		Colorectal(325;3.46e-05)|Lung NSC(340;4.15e-05)|all_lung(284;6.64e-05)|Renal(390;0.000219)|Breast(348;0.00262)|Ovarian(437;0.00539)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;1.52e-24)|Colorectal(126;6.25e-08)|COAD - Colon adenocarcinoma(152;3.42e-06)|GBM - Glioblastoma multiforme(114;8.98e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00102)|KIRC - Kidney renal clear cell carcinoma(1967;0.00366)|STAD - Stomach adenocarcinoma(196;0.0132)|READ - Rectum adenocarcinoma(331;0.0652)|Lung(427;0.0888)|LUSC - Lung squamous cell carcinoma(448;0.19)		CACTGGATGTTGTTCTTGGCC	0.602		NaN											0	0	0	0.010729	0	11	89									
GRHL3	57822	broad.mit.edu	37	1	24661179	24661179	+	Silent	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:24661179G>A	uc001biy.2	+	3	310	c.264G>A	c.(262-264)AGG>AGA	p.R88R	GRHL3_uc001bix.2_Silent_p.R83R|GRHL3_uc001biz.2_5'UTR	NM_021180	NP_067003	Q8TE85	GRHL3_HUMAN	sister-of-mammalian grainyhead protein isoform	83					regulation of actin cytoskeleton organization|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(1)	1		Colorectal(325;3.46e-05)|Renal(390;0.0007)|Lung NSC(340;0.00171)|all_lung(284;0.00226)|Ovarian(437;0.00348)|Breast(348;0.0126)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.19)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;8.72e-25)|Colorectal(126;4.38e-08)|COAD - Colon adenocarcinoma(152;1.84e-06)|GBM - Glioblastoma multiforme(114;0.000132)|BRCA - Breast invasive adenocarcinoma(304;0.00105)|STAD - Stomach adenocarcinoma(196;0.00151)|KIRC - Kidney renal clear cell carcinoma(1967;0.00377)|READ - Rectum adenocarcinoma(331;0.0656)|Lung(427;0.143)		CTGGGGGCAGGAATGACCAAG	0.507		NaN											0	0	0	0.008871	0	19	211									
GPN2	54707	broad.mit.edu	37	1	27216404	27216404	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:27216404C>T	uc001bnd.1	-	1	466	c.184G>A	c.(184-186)GAG>AAG	p.E62K		NM_018066	NP_060536	Q9H9Y4	GPN2_HUMAN	ATP binding domain 1 family, member B	62							GTP binding				0						CCCACCAGCTCGCCCACGTCC	0.701		NaN											0	0	0	0.004878	0	34	10									
SYTL1	84958	broad.mit.edu	37	1	27675622	27675622	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:27675622G>A	uc001bnw.1	+	6	678	c.511G>A	c.(511-513)GAG>AAG	p.E171K	SYTL1_uc001bnv.1_Missense_Mutation_p.E159K|SYTL1_uc009vsu.1_Missense_Mutation_p.E159K|SYTL1_uc001bnx.2_Missense_Mutation_p.E171K|SYTL1_uc009vsv.1_Missense_Mutation_p.E171K	NM_032872	NP_116261	Q8IYJ3	SYTL1_HUMAN	synaptotagmin-like 1	171					exocytosis|intracellular protein transport	extrinsic to plasma membrane|melanosome|soluble fraction	neurexin binding|Rab GTPase binding			ovary(1)	1		Colorectal(325;0.000147)|all_lung(284;0.000366)|Lung NSC(340;0.000548)|Renal(390;0.00211)|Breast(348;0.0115)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0908)|all_neural(195;0.0966)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0416)|OV - Ovarian serous cystadenocarcinoma(117;1.5e-28)|Colorectal(126;1.24e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|BRCA - Breast invasive adenocarcinoma(304;0.0013)|KIRC - Kidney renal clear cell carcinoma(1967;0.00158)|STAD - Stomach adenocarcinoma(196;0.00303)|READ - Rectum adenocarcinoma(331;0.0419)		AGATCCTGAGGAGGCGTCCCA	0.617		NaN											0	0	0	0.007413	0	20	53									
FCN3	8547	broad.mit.edu	37	1	27695779	27695779	+	Nonsense_Mutation	SNP	G	G	C			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:27695779G>C	uc001boa.2	-	8	854	c.848C>G	c.(847-849)TCA>TGA	p.S283*	MAP3K6_uc001bny.1_5'Flank|MAP3K6_uc009vsw.1_5'Flank|FCN3_uc001bob.2_Nonsense_Mutation_p.S272*	NM_003665	NP_003656	O75636	FCN3_HUMAN	ficolin 3 isoform 1 precursor	283	Fibrinogen C-terminal.				complement activation, lectin pathway|signal transduction	collagen|extracellular space	receptor binding|sugar binding				0		all_lung(284;1.6e-05)|Lung NSC(340;2.92e-05)|Colorectal(325;3.46e-05)|Renal(390;0.0007)|Breast(348;0.0021)|Ovarian(437;0.0175)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0415)|OV - Ovarian serous cystadenocarcinoma(117;1.42e-27)|Colorectal(126;1.24e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00128)|KIRC - Kidney renal clear cell carcinoma(1967;0.00155)|STAD - Stomach adenocarcinoma(196;0.00303)|READ - Rectum adenocarcinoma(331;0.0419)		ACCACGGCCTGAGGCCCAGTC	0.577		NaN											0	0	0	0.010729	0	10	65									
SDC3	9672	broad.mit.edu	37	1	31346158	31346158	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:31346158C>T	uc001bse.2	-	5	1276	c.1229G>A	c.(1228-1230)CGT>CAT	p.R410H	SDC3_uc001bsd.2_Missense_Mutation_p.R352H	NM_014654	NP_055469	O75056	SDC3_HUMAN	syndecan 3	410	Cytoplasmic (Potential).					integral to membrane	cytoskeletal protein binding			ovary(1)|central_nervous_system(1)	2		Myeloproliferative disorder(586;0.0393)|Colorectal(325;0.0466)|all_neural(195;0.0966)|Ovarian(437;0.127)|Medulloblastoma(700;0.151)		STAD - Stomach adenocarcinoma(196;0.0197)|READ - Rectum adenocarcinoma(331;0.0649)		TTTCTTCATACGATAGATGAG	0.562		NaN											0	0	0	0.00245	0	13	66									
RBBP4	5928	broad.mit.edu	37	1	33138430	33138430	+	Silent	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:33138430C>T	uc001bvr.2	+	11	1299	c.1140C>T	c.(1138-1140)TTC>TTT	p.F380F	RBBP4_uc001bvs.2_Silent_p.F379F|RBBP4_uc010ohj.1_Silent_p.F128F|RBBP4_uc010ohk.1_Silent_p.F345F	NM_005610	NP_005601	Q09028	RBBP4_HUMAN	retinoblastoma binding protein 4 isoform a	380	WD 6.				cell cycle|CenH3-containing nucleosome assembly at centromere|DNA replication|negative regulation of cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	CAF-1 complex|ESC/E(Z) complex|NuRD complex|NURF complex|Sin3 complex	histone binding|histone deacetylase binding			ovary(1)	1		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)				TATCTGATTTCTCCTGGAATC	0.373		NaN											0	0	0	0.00499	0	16	96									
C1orf216	127703	broad.mit.edu	37	1	36181308	36181308	+	Silent	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:36181308G>A	uc001bzh.1	-	2	1103	c.615C>T	c.(613-615)ATC>ATT	p.I205I		NM_152374	NP_689587	Q8TAB5	CA216_HUMAN	hypothetical protein LOC127703	205										skin(1)	1		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.196)				GGTTGTCTAGGATGGTGTCGA	0.607		NaN									OREG0013357	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.00333	0	22	108									
GRIK3	2899	broad.mit.edu	37	1	37499707	37499707	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:37499707C>T	uc001caz.2	-	1	138	c.3G>A	c.(1-3)ATG>ATA	p.M1I	GRIK3_uc001cba.1_Missense_Mutation_p.M1I	NM_000831	NP_000822	Q13003	GRIK3_HUMAN	glutamate receptor, ionotropic, kainate 3	1					negative regulation of synaptic transmission, glutamatergic|regulation of membrane potential|synaptic transmission	cell junction|dendrite cytoplasm|integral to plasma membrane|perikaryon|postsynaptic membrane|terminal button	adenylate cyclase inhibiting metabotropic glutamate receptor activity|extracellular-glutamate-gated ion channel activity|G-protein-coupled receptor binding|kainate selective glutamate receptor activity			ovary(3)|skin(2)|large_intestine(1)|breast(1)	7		Myeloproliferative disorder(586;0.0258)|all_neural(195;0.169)			L-Glutamic Acid(DB00142)	AGGGAGCGGTCATCGTTGGGC	0.771		NaN											0	0	0	0.004672	0	3	3									
ZC3H12A	80149	broad.mit.edu	37	1	37947425	37947425	+	Silent	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:37947425C>T	uc001cbb.3	+	4	957	c.807C>T	c.(805-807)TTC>TTT	p.F269F	ZC3H12A_uc001cbc.1_5'UTR	NM_025079	NP_079355	Q5D1E8	ZC12A_HUMAN	zinc finger CCCH-type containing 12A	269					angiogenesis|apoptosis|cell differentiation	cytoplasm|nucleus|plasma membrane	endonuclease activity|metal ion binding			ovary(2)	2		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				TGTACTCCTTCGTCAATGACA	0.612		NaN											0	0	0	0.001855	0	13	21									
EPHA10	284656	broad.mit.edu	37	1	38197174	38197174	+	Silent	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:38197174G>A	uc009vvi.2	-	7	1658	c.1572C>T	c.(1570-1572)CGC>CGT	p.R524R	EPHA10_uc009vvh.1_RNA|EPHA10_uc001cbu.2_RNA|EPHA10_uc001cbv.1_RNA	NM_001099439	NP_001092909	Q5JZY3	EPHAA_HUMAN	EPH receptor A10 isofom 3	524	Fibronectin type-III 2.|Extracellular (Potential).					extracellular region|integral to membrane|integral to plasma membrane	ATP binding|ephrin receptor activity|protein binding|transmembrane-ephrin receptor activity			breast(4)|stomach(3)|lung(1)	8	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				GAAAGACGTAGCGGGTAGCCG	0.587		NaN											0	0	0	0.01441	0	40	72									
MACF1	23499	broad.mit.edu	37	1	39797480	39797480	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:39797480G>C	uc010oiu.1	+	1	671	c.540G>C	c.(538-540)TTG>TTC	p.L180F	MACF1_uc010ois.1_Intron|MACF1_uc001cda.1_Intron|MACF1_uc001cdc.1_Intron|MACF1_uc001cdb.1_Intron	NM_033044	NP_149033	Q9UPN3	MACF1_HUMAN	microfilament and actin filament cross-linker	1745					cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			ovary(8)|breast(3)|central_nervous_system(3)|skin(2)	16	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			TGGTGAGCTTGAAATCAGGCC	0.488		NaN											0	0	0	0.006214	0	10	165									
MACF1	23499	broad.mit.edu	37	1	39799895	39799895	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:39799895G>T	uc010oiu.1	+	1	3086	c.2955G>T	c.(2953-2955)CAG>CAT	p.Q985H	MACF1_uc010ois.1_Intron|MACF1_uc001cda.1_Intron|MACF1_uc001cdc.1_Intron|MACF1_uc001cdb.1_Intron	NM_033044	NP_149033	Q9UPN3	MACF1_HUMAN	microfilament and actin filament cross-linker	2550					cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			ovary(8)|breast(3)|central_nervous_system(3)|skin(2)	16	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			ACATCCATCAGATTTTTAATC	0.378		NaN											1	0	7.38237e-10	0.00632	7.64262e-10	26	248									
MACF1	23499	broad.mit.edu	37	1	39800966	39800966	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:39800966G>C	uc010oiu.1	+	1	4157	c.4026G>C	c.(4024-4026)ATG>ATC	p.M1342I	MACF1_uc010ois.1_Intron|MACF1_uc001cda.1_Intron|MACF1_uc001cdc.1_Intron|MACF1_uc001cdb.1_Intron	NM_033044	NP_149033	Q9UPN3	MACF1_HUMAN	microfilament and actin filament cross-linker	2907					cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			ovary(8)|breast(3)|central_nervous_system(3)|skin(2)	16	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			GAAATAACATGGGAAATGATA	0.338		NaN											0	0	0	0.008871	0	20	214									
KIAA0754	643314	broad.mit.edu	37	1	39876601	39876601	+	Nonsense_Mutation	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:39876601C>T	uc009vvt.1	+	1	1426	c.664C>T	c.(664-666)CAG>TAG	p.Q222*	MACF1_uc010ois.1_Intron|MACF1_uc001cda.1_Intron|MACF1_uc001cdc.1_Intron|MACF1_uc010oiu.1_Intron	NM_015038	NP_055853	O94854	K0754_HUMAN	hypothetical protein LOC643314	86	13 X 13 AA approximate tandem repeat of P-T-S-P-A-A-A-V-P-T-P-E-E.										0	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0393)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			CTTTAGATTTCAGCAGCACAG	0.433		NaN									OREG0013393	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.010818	0	31	144									
CCDC30	728621	broad.mit.edu	37	1	43042700	43042700	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:43042700G>A	uc009vwk.1	+	7	975	c.865G>A	c.(865-867)GAA>AAA	p.E289K	CCDC30_uc001chm.2_5'UTR|CCDC30_uc001chn.2_Missense_Mutation_p.E78K|CCDC30_uc010oju.1_RNA|CCDC30_uc001chp.2_Missense_Mutation_p.E103K	NM_001080850	NP_001074319	Q5VVM6	CCD30_HUMAN	coiled-coil domain containing 30	289	Potential.										0						GATAAAGATTGAACTAAAGCA	0.388		NaN											0	0	0	0.001855	0	13	53									
IPO13	9670	broad.mit.edu	37	1	44424218	44424218	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:44424218C>G	uc001ckx.2	+	10	2630	c.1835C>G	c.(1834-1836)TCG>TGG	p.S612W		NM_014652	NP_055467	O94829	IPO13_HUMAN	importin 13	612	HEAT 10.				protein import into nucleus	cytoplasm|nucleus	protein binding|protein transporter activity			central_nervous_system(1)	1	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0821)				AACCTGCACTCGCTTATCTCA	0.562		NaN											0	0	0	0.003163	0	14	186									
ERI3	79033	broad.mit.edu	37	1	44785309	44785309	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:44785309G>C	uc001clt.2	-	4	838	c.597C>G	c.(595-597)TTC>TTG	p.F199L	ERI3_uc010okv.1_Missense_Mutation_p.F22L|ERI3_uc009vxg.2_Missense_Mutation_p.F199L|ERI3_uc010okw.1_Missense_Mutation_p.F121L|ERI3_uc001clu.2_Missense_Mutation_p.F121L	NM_024066	NP_076971	O43414	ERI3_HUMAN	prion protein interacting protein	199	Exonuclease.					intracellular	exonuclease activity|metal ion binding|nucleic acid binding			ovary(2)|large_intestine(1)	3						CCTCTGTACAGAATGGGGTAA	0.512		NaN											0	0	0	0.00632	0	25	169									
PLK3	1263	broad.mit.edu	37	1	45269324	45269324	+	Silent	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:45269324C>T	uc001cmn.2	+	9	1225	c.1125C>T	c.(1123-1125)CTC>CTT	p.L375L	PLK3_uc001cmo.2_RNA	NM_004073	NP_004064	Q9H4B4	PLK3_HUMAN	polo-like kinase 3	375						membrane	ATP binding|protein binding|protein serine/threonine kinase activity				0	Acute lymphoblastic leukemia(166;0.155)					TGAGCGGCCTCATGCGCACAT	0.617		NaN											0	0	0	0.00308	0	7	22									
ZSWIM5	57643	broad.mit.edu	37	1	45484612	45484612	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:45484612C>G	uc001cnd.2	-	14	3300	c.3072G>C	c.(3070-3072)ATG>ATC	p.M1024I		NM_020883	NP_065934	Q9P217	ZSWM5_HUMAN	zinc finger, SWIM domain containing 5	1024							zinc ion binding				0	Acute lymphoblastic leukemia(166;0.155)					TAAGATGGCTCATGGCCAATG	0.567		NaN									OREG0013450	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.010729	0	12	87									
AKR1A1	10327	broad.mit.edu	37	1	46034629	46034629	+	Silent	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:46034629C>T	uc001cod.2	+	8	1247	c.783C>T	c.(781-783)ATC>ATT	p.I261I	AKR1A1_uc001coe.2_Silent_p.I261I|AKR1A1_uc001cof.2_Silent_p.I67I|AKR1A1_uc001cog.2_RNA	NM_006066	NP_006057	P14550	AK1A1_HUMAN	aldo-keto reductase family 1, member A1	261	NADP (By similarity).				glucose metabolic process		alditol:NADP+ 1-oxidoreductase activity|electron carrier activity|protein binding				0	Acute lymphoblastic leukemia(166;0.155)					TGATCTGCATCCCCAAAAGTA	0.453		NaN											0	0	0	0.01441	0	155	114									
DMBX1	127343	broad.mit.edu	37	1	46976269	46976269	+	Missense_Mutation	SNP	T	T	G			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:46976269T>G	uc001cpx.2	+	2	306	c.291T>G	c.(289-291)GAT>GAG	p.D97E	DMBX1_uc001cpw.2_Missense_Mutation_p.D92E	NM_147192	NP_671725	Q8NFW5	DMBX1_HUMAN	diencephalon/mesencephalon homeobox 1 isoform b	97	Homeobox.|Interacts with OXT2 and is required for repressor activity (By similarity).				brain development|developmental growth|negative regulation of transcription, DNA-dependent	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1	Acute lymphoblastic leukemia(166;0.155)					ACTACCCAGATGTGGTGATGC	0.597		NaN											0	0	0	0.00632	0	26	35									
MYSM1	114803	broad.mit.edu	37	1	59142623	59142623	+	Silent	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:59142623C>T	uc009wab.1	-	9	1388	c.1365G>A	c.(1363-1365)TTG>TTA	p.L455L	MYSM1_uc001czc.2_RNA	NM_001085487	NP_001078956	Q5VVJ2	MYSM1_HUMAN	Myb-like, SWIRM and MPN domains 1	455	SWIRM.				histone deubiquitination|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromatin remodeling complex	DNA binding|histone binding|metal ion binding|metallopeptidase activity|transcription coactivator activity|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			skin(1)	1	all_cancers(7;9.36e-06)					TTGCTCCTATCAATTCGAGGT	0.348		NaN											0	0	0	0.01441	0	53	110									
DOCK7	85440	broad.mit.edu	37	1	63024891	63024891	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:63024891C>T	uc001daq.2	-	20	2234	c.2200G>A	c.(2200-2202)GAT>AAT	p.D734N	DOCK7_uc001dan.2_Missense_Mutation_p.D626N|DOCK7_uc001dao.2_Missense_Mutation_p.D626N|DOCK7_uc001dap.2_Missense_Mutation_p.D734N	NM_033407	NP_212132	Q96N67	DOCK7_HUMAN	dedicator of cytokinesis 7	734	DHR-1.				activation of Rac GTPase activity|axonogenesis|establishment of neuroblast polarity|microtubule cytoskeleton organization|positive regulation of peptidyl-serine phosphorylation	axon|basal part of cell|growth cone	GTP binding|guanyl-nucleotide exchange factor activity|Rac GTPase binding			ovary(2)	2						AGATAAGGATCCTAAAACAAA	0.363		NaN											0	0	0	0.004482	0	7	34									
ANGPTL3	27329	broad.mit.edu	37	1	63066796	63066796	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:63066796C>G	uc001das.1	+	3	701	c.650C>G	c.(649-651)TCT>TGT	p.S217C	DOCK7_uc001dan.2_Intron|DOCK7_uc001dao.2_Intron|DOCK7_uc001dap.2_Intron|DOCK7_uc001daq.2_Intron|DOCK7_uc009wah.1_Intron	NM_014495	NP_055310	Q9Y5C1	ANGL3_HUMAN	angiopoietin-like 3 precursor	217					acylglycerol homeostasis|artery morphogenesis|cell-matrix adhesion|cholesterol homeostasis|cholesterol metabolic process|fatty acid metabolic process|glycerol metabolic process|integrin-mediated signaling pathway|lipid storage|negative regulation of lipoprotein lipase activity|negative regulation of phospholipase activity|phospholipid catabolic process|phospholipid homeostasis|positive regulation of angiogenesis|positive regulation of cell migration|positive regulation of lipid catabolic process|triglyceride homeostasis	extracellular space	cell surface binding|growth factor activity|integrin binding|phospholipase inhibitor activity				0						ATTTCTCTATCTTCCAAGCCA	0.343		NaN											0	0	0	0.012319	0	22	131									
MIER1	57708	broad.mit.edu	37	1	67411832	67411833	+	Splice_Site	DNP	GG	GG	TT			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:67411832_67411833GG>TT	uc001dde.2	+	4	328	c.194_splice	c.e4-1	p.G65_splice	MIER1_uc001dda.3_Splice_Site_p.E90_splice|MIER1_uc010opf.1_Splice_Site_p.G29_splice|MIER1_uc009way.2_Splice_Site_p.G29_splice|MIER1_uc001ddc.2_Splice_Site_p.G65_splice|MIER1_uc001ddh.2_Intron|MIER1_uc001ddf.2_Splice_Site_p.G29_splice|MIER1_uc001ddg.2_Splice_Site|MIER1_uc010opg.1_Splice_Site_p.G29_splice|MIER1_uc001ddj.1_Splice_Site_p.G12_splice|MIER1_uc001ddi.2_Splice_Site_p.G12_splice	NM_001077700	NP_001071168	Q8N108	MIER1_HUMAN	mesoderm induction early response 1 isoform b						positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|signal transducer activity			ovary(1)	1						TTCCTTACCAGGAGGTTCAGCA	0.317		NaN											0	0	0	0.004672	0	26	90									
ANKRD13C	81573	broad.mit.edu	37	1	70728465	70728465	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:70728465C>T	uc001dex.3	-	13	1887	c.1561G>A	c.(1561-1563)GAT>AAT	p.D521N	ANKRD13C_uc009wbk.2_Missense_Mutation_p.D486N	NM_030816	NP_110443	Q8N6S4	AN13C_HUMAN	ankyrin repeat domain 13C	521					protein retention in ER lumen|regulation of anoikis|regulation of receptor biosynthetic process	endoplasmic reticulum membrane|perinuclear region of cytoplasm	receptor binding				0						ATGGAGCCATCAAATTCATCG	0.408		NaN											0	0	0	0.01441	0	61	138									
FUBP1	8880	broad.mit.edu	37	1	78430866	78430866	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:78430866G>A	uc001dii.2	-	8	612	c.523C>T	c.(523-525)CCT>TCT	p.P175S	FUBP1_uc001dih.3_RNA|FUBP1_uc010orm.1_Missense_Mutation_p.P196S	NM_003902	NP_003893	Q96AE4	FUBP1_HUMAN	far upstream element-binding protein	175					transcription from RNA polymerase II promoter	nucleus	protein binding|RNA binding|sequence-specific DNA binding transcription factor activity|single-stranded DNA binding			central_nervous_system(2)|lung(1)	3						TGGAAGCCAGGAGCTGGTCTT	0.418		NaN											0	0	0	0.009535	0	30	141									
DNASE2B	58511	broad.mit.edu	37	1	84867740	84867740	+	Silent	SNP	A	A	G			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:84867740A>G	uc001djt.1	+	2	315	c.282A>G	c.(280-282)CTA>CTG	p.L94L		NM_021233	NP_067056	Q8WZ79	DNS2B_HUMAN	deoxyribonuclease II beta isoform 1 precursor	94					DNA metabolic process	lysosome	deoxyribonuclease II activity				0				all cancers(265;0.00303)|Epithelial(280;0.0112)|OV - Ovarian serous cystadenocarcinoma(397;0.0808)		TACAACAGCTATATGAAGCAT	0.363		NaN						Direct_reversal_of_damage					0	0	0	0.001168	0	6	28									
COL24A1	255631	broad.mit.edu	37	1	86426951	86426951	+	Missense_Mutation	SNP	A	A	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:86426951A>T	uc001dlj.2	-	24	2585	c.2543T>A	c.(2542-2544)ATT>AAT	p.I848N	COL24A1_uc001dli.2_Translation_Start_Site|COL24A1_uc010osd.1_Missense_Mutation_p.I148N|COL24A1_uc001dlk.2_RNA|COL24A1_uc010ose.1_RNA|COL24A1_uc010osf.1_RNA	NM_152890	NP_690850	Q17RW2	COOA1_HUMAN	collagen, type XXIV, alpha 1 precursor	848	Collagen-like 5.			GYAGEPGPEGLKGEVGDQGNIG -> ITVFATLYSFLTGRS RRSRKYW (in Ref. 5; BAD92923).	cell adhesion	collagen	extracellular matrix structural constituent			ovary(3)|central_nervous_system(1)|skin(1)	5				all cancers(265;0.0627)|Epithelial(280;0.0689)		AATTTTTCCAATATTTCCTTG	0.289		NaN											0	0	0	0.003163	0	15	96									
ZNF644	84146	broad.mit.edu	37	1	91406420	91406420	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:91406420G>A	uc001dnw.2	-	3	633	c.491C>T	c.(490-492)TCT>TTT	p.S164F	ZNF644_uc001dnv.2_Intron|ZNF644_uc001dnx.2_Intron|ZNF644_uc001dny.1_Missense_Mutation_p.S164F	NM_201269	NP_958357	Q9H582	ZN644_HUMAN	zinc finger protein 644 isoform 1	164					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|breast(1)|skin(1)	3		all_lung(203;0.00206)|Lung NSC(277;0.0519)|Lung SC(238;0.101)		all cancers(265;0.00102)|Epithelial(280;0.00766)|KIRC - Kidney renal clear cell carcinoma(1967;0.147)|OV - Ovarian serous cystadenocarcinoma(397;0.173)		CTGTGGTGTAGACAGCTGAAG	0.403		NaN											0	0	0	0.005443	0	29	150									
MTF2	22823	broad.mit.edu	37	1	93580289	93580289	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:93580289G>C	uc009wdj.2	+	4	623	c.331G>C	c.(331-333)GAG>CAG	p.E111Q	MTF2_uc001dph.2_Missense_Mutation_p.E9Q|MTF2_uc010oth.1_Missense_Mutation_p.E9Q|MTF2_uc009wdk.2_Missense_Mutation_p.E111Q|MTF2_uc001dpi.3_5'UTR|MTF2_uc010oti.1_Missense_Mutation_p.E9Q|MTF2_uc001dpj.3_Missense_Mutation_p.E9Q|MTF2_uc001dpl.3_Missense_Mutation_p.E9Q	NM_007358	NP_031384	Q9Y483	MTF2_HUMAN	metal response element binding transcription	111	PHD-type 1.					nucleus	DNA binding|zinc ion binding			ovary(2)	2		all_lung(203;0.00196)|Lung NSC(277;0.00902)|Melanoma(281;0.099)|Ovarian(761;0.109)|all_neural(321;0.185)|Glioma(108;0.203)		all cancers(265;0.00076)|GBM - Glioblastoma multiforme(16;0.00157)|Epithelial(280;0.0886)		ATGTCAAGAAGAGTATTCAGA	0.328		NaN											0	0	0	0.013537	0	10	55									
CNN3	1266	broad.mit.edu	37	1	95363303	95363303	+	Missense_Mutation	SNP	A	A	C			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:95363303A>C	uc010otw.1	-	8	1067	c.985T>G	c.(985-987)TAT>GAT	p.Y329D	CNN3_uc010otv.1_Missense_Mutation_p.Y288D|CNN3_uc001dqz.3_Missense_Mutation_p.Y329D|CNN3_uc010otx.1_Missense_Mutation_p.Y283D	NM_001839	NP_001830	Q15417	CNN3_HUMAN	calponin 3	329	Asp/Glu-rich (acidic).				actomyosin structure organization|smooth muscle contraction		actin binding|calmodulin binding|tropomyosin binding|troponin C binding				0		all_lung(203;0.00206)|Lung NSC(277;0.00948)		all cancers(265;0.0325)|Epithelial(280;0.0861)		TGGATCTAATAATCAATGCCT	0.398		NaN											0	0	0	0.013726	0	33	154									
CNN3	1266	broad.mit.edu	37	1	95363318	95363318	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:95363318C>T	uc010otw.1	-	8	1052	c.970G>A	c.(970-972)GAC>AAC	p.D324N	CNN3_uc010otv.1_Missense_Mutation_p.D283N|CNN3_uc001dqz.3_Missense_Mutation_p.D324N|CNN3_uc010otx.1_Missense_Mutation_p.D278N	NM_001839	NP_001830	Q15417	CNN3_HUMAN	calponin 3	324	Asp/Glu-rich (acidic).				actomyosin structure organization|smooth muscle contraction		actin binding|calmodulin binding|tropomyosin binding|troponin C binding				0		all_lung(203;0.00206)|Lung NSC(277;0.00948)		all cancers(265;0.0325)|Epithelial(280;0.0861)		ATGCCTTGGTCGCTATATTGG	0.398		NaN											0	0	0	0.006999	0	39	175									
LPPR5	163404	broad.mit.edu	37	1	99387500	99387500	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:99387500G>A	uc001dsb.2	-	4	958	c.736C>T	c.(736-738)CGA>TGA	p.R246*	LPPR5_uc001dsc.2_Nonsense_Mutation_p.R246*	NM_001037317	NP_001032394	Q32ZL2	LPPR5_HUMAN	phosphatidic acid phosphatase type 2d isoform 1	246						integral to membrane	hydrolase activity				0						CAATGATTTCGATATTCTGCT	0.368		NaN											0	0	0	0.004878	0	35	116									
FRRS1	391059	broad.mit.edu	37	1	100212977	100212977	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:100212977G>A	uc001dsh.1	-	4	808	c.206C>T	c.(205-207)TCA>TTA	p.S69L		NM_001013660	NP_001013682	Q6ZNA5	FRRS1_HUMAN	stromal cell derived factor receptor 2 homolog	69	Reelin.				electron transport chain|transport	integral to membrane	ferric-chelate reductase activity|metal ion binding			skin(1)	1		all_epithelial(167;2.09e-06)|all_lung(203;0.000435)|Lung NSC(277;0.00201)		Epithelial(280;0.0718)|all cancers(265;0.126)|COAD - Colon adenocarcinoma(174;0.148)|Lung(183;0.206)		TGGATGCCCTGACAAAGTAAC	0.378		NaN											0	0	0	0.008361	0	29	115									
FNDC7	163479	broad.mit.edu	37	1	109276098	109276098	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:109276098C>T	uc001dvx.2	+	10	2084	c.2084C>T	c.(2083-2085)TCA>TTA	p.S695L	FNDC7_uc010ova.1_Missense_Mutation_p.S462L	NM_001144937	NP_001138409	Q5VTL7	FNDC7_HUMAN	fibronectin type III domain containing 7	696	Fibronectin type-III 8.					extracellular region				ovary(1)|skin(1)	2		all_lung(203;0.00439)|Lung NSC(277;0.00683)|all_epithelial(167;0.00728)		Colorectal(144;0.0314)|Lung(183;0.0924)|COAD - Colon adenocarcinoma(174;0.119)|Epithelial(280;0.173)|all cancers(265;0.244)		GTGATGGTCTCACCAGTTGCT	0.423		NaN											0	0	0	0.012319	0	23	94									
CSF1	1435	broad.mit.edu	37	1	110466437	110466437	+	Silent	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:110466437G>A	uc001dyu.2	+	6	1607	c.1194G>A	c.(1192-1194)CCG>CCA	p.P398P	CSF1_uc001dyt.2_Intron|CSF1_uc001dyv.3_Intron|CSF1_uc001dyw.3_Silent_p.P398P	NM_172212	NP_757351	P09603	CSF1_HUMAN	colony stimulating factor 1 isoform a precursor	398	Lumenal (Potential).				cell proliferation|developmental process involved in reproduction|macrophage differentiation|monocyte activation|osteoclast differentiation|positive regulation of cell migration|positive regulation of cell-matrix adhesion|positive regulation of cellular protein metabolic process|positive regulation of gene expression|positive regulation of macrophage derived foam cell differentiation|positive regulation of macrophage differentiation|positive regulation of monocyte differentiation|positive regulation of mononuclear cell proliferation|positive regulation of protein kinase activity	extracellular space|integral to membrane|perinuclear region of cytoplasm|plasma membrane|receptor complex	cytokine activity|growth factor activity|macrophage colony-stimulating factor receptor binding|protein homodimerization activity			ovary(1)	1		all_epithelial(167;3.58e-05)|all_lung(203;0.000116)|Lung NSC(277;0.000233)|Acute lymphoblastic leukemia(138;0.204)		Lung(183;0.0238)|Colorectal(144;0.112)|all cancers(265;0.117)|Epithelial(280;0.127)|LUSC - Lung squamous cell carcinoma(189;0.135)		GAGACCCCCCGGAGCCAGGCT	0.667		NaN											0	0	0	0.010729	0	9	44									
RBM15	64783	broad.mit.edu	37	1	110884629	110884629	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:110884629G>A	uc001dzl.1	+	1	2685	c.2602G>A	c.(2602-2604)GAC>AAC	p.D868N	RBM15_uc001dzm.1_Missense_Mutation_p.D868N|uc001dzj.2_5'Flank	NM_022768	NP_073605	Q96T37	RBM15_HUMAN	RNA binding motif protein 15	868	SPOC.				interspecies interaction between organisms	nucleus	nucleotide binding|protein binding|RNA binding			ovary(3)	3		all_cancers(81;2.89e-06)|all_epithelial(167;2.96e-06)|all_lung(203;0.000116)|Lung NSC(277;0.000233)|Breast(1374;0.0634)		BRCA - Breast invasive adenocarcinoma(282;0.000224)|Epithelial(280;0.000476)|Kidney(133;0.000539)|KIRC - Kidney renal clear cell carcinoma(1967;0.000716)|all cancers(265;0.00144)|Lung(183;0.0238)|Colorectal(144;0.103)|LUSC - Lung squamous cell carcinoma(189;0.135)		TGGAAGTTCTGACAGCCGGTC	0.512		NaN	T	MKL1	acute megakaryocytic leukemia								0	0	0	0.00245	0	13	67									
DENND2D	79961	broad.mit.edu	37	1	111730906	111730906	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:111730906G>A	uc001eak.1	-	11	1386	c.1186C>T	c.(1186-1188)CGG>TGG	p.R396W	DENND2D_uc001eal.1_Missense_Mutation_p.R393W	NM_024901	NP_079177	Q9H6A0	DEN2D_HUMAN	DENN/MADD domain containing 2D	396	dDENN.									ovary(1)	1		all_cancers(81;0.00198)|all_epithelial(167;0.000686)|all_lung(203;0.00318)|Lung NSC(277;0.00499)		Lung(183;0.0162)|Colorectal(144;0.069)|all cancers(265;0.0757)|LUSC - Lung squamous cell carcinoma(189;0.0845)|Epithelial(280;0.114)|COAD - Colon adenocarcinoma(174;0.14)		TTTGCCTCCCGCTTGATATAG	0.473		NaN											0	0	0	0.004656	0	26	114									
WDR77	79084	broad.mit.edu	37	1	111983905	111983905	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:111983905C>T	uc001ebb.2	-	10	1015	c.976G>A	c.(976-978)GTT>ATT	p.V326I	WDR77_uc010owd.1_RNA|WDR77_uc010owe.1_Missense_Mutation_p.V262I	NM_024102	NP_077007	Q9BQA1	MEP50_HUMAN	WD repeat domain 77	326				LTTVGWDHQVVHHVVPTEPLPAPGPASVTE -> DLQVLLS RLDLRQKASPP (in Ref. 7; AAH09411).	ncRNA metabolic process|spliceosomal snRNP assembly	cytosol|nucleus	ligand-dependent nuclear receptor transcription coactivator activity|protein binding				0		all_cancers(81;0.000902)|all_epithelial(167;0.00056)|all_lung(203;0.00277)|Lung NSC(277;0.0043)		Lung(183;0.0238)|Colorectal(144;0.0296)|all cancers(265;0.0488)|Epithelial(280;0.0732)|COAD - Colon adenocarcinoma(174;0.114)|LUSC - Lung squamous cell carcinoma(189;0.135)		GTGGGCACAACGTGGTGGACG	0.537		NaN											0	0	0	0.010504	0	22	55									
MOV10	4343	broad.mit.edu	37	1	113217604	113217604	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:113217604C>T	uc001eck.2	+	2	340	c.70C>T	c.(70-72)CGG>TGG	p.R24W	MOV10_uc001ecl.2_Missense_Mutation_p.R24W|MOV10_uc001ecn.2_Missense_Mutation_p.R24W|MOV10_uc001ecm.2_5'UTR|MOV10_uc009wgj.1_5'UTR	NM_001130079	NP_001123551	Q9HCE1	MOV10_HUMAN	Mov10, Moloney leukemia virus 10, homolog	24					mRNA cleavage involved in gene silencing by miRNA|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body	ATP binding|helicase activity|protein binding|RNA binding			ovary(4)|skin(1)	5	Lung SC(450;0.246)	all_cancers(81;3.31e-11)|all_epithelial(167;5.69e-10)|all_lung(203;3.73e-05)|Breast(1374;0.000525)|Lung NSC(69;0.000954)|Ovarian(761;0.0367)|Lung SC(238;0.114)		OV - Ovarian serous cystadenocarcinoma(397;3.99e-67)|all cancers(265;1e-62)|Epithelial(280;4.78e-61)|Lung(183;0.0234)|Colorectal(144;0.0686)|READ - Rectum adenocarcinoma(129;0.0929)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)|BRCA - Breast invasive adenocarcinoma(282;0.24)		CCTGGTCGTTCGGGGACTGGA	0.667		NaN											0	0	0	0.006214	0	8	47									
MOV10	4343	broad.mit.edu	37	1	113234326	113234326	+	Silent	SNP	G	G	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:113234326G>T	uc001eck.2	+	6	1146	c.876G>T	c.(874-876)GGG>GGT	p.G292G	MOV10_uc001ecl.2_Silent_p.G292G|MOV10_uc001ecn.2_Silent_p.G292G|MOV10_uc001ecm.2_Silent_p.G232G|MOV10_uc009wgj.1_Silent_p.G232G	NM_001130079	NP_001123551	Q9HCE1	MOV10_HUMAN	Mov10, Moloney leukemia virus 10, homolog	292					mRNA cleavage involved in gene silencing by miRNA|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body	ATP binding|helicase activity|protein binding|RNA binding			ovary(4)|skin(1)	5	Lung SC(450;0.246)	all_cancers(81;3.31e-11)|all_epithelial(167;5.69e-10)|all_lung(203;3.73e-05)|Breast(1374;0.000525)|Lung NSC(69;0.000954)|Ovarian(761;0.0367)|Lung SC(238;0.114)		OV - Ovarian serous cystadenocarcinoma(397;3.99e-67)|all cancers(265;1e-62)|Epithelial(280;4.78e-61)|Lung(183;0.0234)|Colorectal(144;0.0686)|READ - Rectum adenocarcinoma(129;0.0929)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)|BRCA - Breast invasive adenocarcinoma(282;0.24)		TGGCGCTGGGGACATACTACC	0.542		NaN											1	0	8.10497e-08	0.010504	8.35144e-08	20	79									
LRIG2	9860	broad.mit.edu	37	1	113657463	113657463	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:113657463G>A	uc001edf.1	+	15	2693	c.2495G>A	c.(2494-2496)AGA>AAA	p.R832K	LRIG2_uc009wgn.1_Missense_Mutation_p.R729K	NM_014813	NP_055628	O94898	LRIG2_HUMAN	leucine-rich repeats and immunoglobulin-like	832	Cytoplasmic (Potential).					cytoplasm|integral to membrane|plasma membrane				ovary(3)	3	Lung SC(450;0.246)	all_cancers(81;1.56e-05)|all_epithelial(167;2.62e-05)|all_lung(203;0.000665)|Lung NSC(69;0.000986)		Lung(183;0.0279)|Colorectal(144;0.0885)|COAD - Colon adenocarcinoma(174;0.134)|all cancers(265;0.139)|Epithelial(280;0.143)|LUSC - Lung squamous cell carcinoma(189;0.15)		TACCACATGAGAAGGAAAAAT	0.398		NaN											0	0	0	0.008871	0	20	96									
OLFML3	56944	broad.mit.edu	37	1	114524373	114524373	+	Silent	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:114524373G>A	uc001eer.1	+	3	1312	c.1203G>A	c.(1201-1203)AAG>AAA	p.K401K	OLFML3_uc001ees.1_Silent_p.K381K|OLFML3_uc001eet.1_Silent_p.K257K	NM_020190	NP_064575	Q9NRN5	OLFL3_HUMAN	olfactomedin-like 3 precursor	401	Olfactomedin-like.				multicellular organismal development	extracellular region					0	Lung SC(450;0.184)	all_cancers(81;4.5e-08)|all_epithelial(167;1.09e-07)|all_lung(203;1.53e-05)|Lung NSC(69;2.76e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		AGATGAGGAAGAAAGAGGAGG	0.458		NaN											0	0	0	0.004482	0	8	26									
APH1A	51107	broad.mit.edu	37	1	150238976	150238976	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:150238976G>C	uc001ety.1	-	6	1012	c.690C>G	c.(688-690)ATC>ATG	p.I230M	APH1A_uc010pbx.1_Missense_Mutation_p.I160M|APH1A_uc001etz.1_Missense_Mutation_p.I230M|APH1A_uc001eua.1_Missense_Mutation_p.I230M|APH1A_uc010pby.1_Missense_Mutation_p.I173M|APH1A_uc001eub.1_Missense_Mutation_p.I114M|APH1A_uc010pbz.1_Missense_Mutation_p.I114M	NM_001077628	NP_001071096	Q96BI3	APH1A_HUMAN	anterior pharynx defective 1 homolog A isoform	230	Helical; Name=7; (Potential).				amyloid precursor protein catabolic process|apoptosis|induction of apoptosis by extracellular signals|membrane protein ectodomain proteolysis|membrane protein intracellular domain proteolysis|nerve growth factor receptor signaling pathway|Notch receptor processing|Notch signaling pathway|positive regulation of catalytic activity|protein processing	endoplasmic reticulum membrane|Golgi cisterna membrane|integral to plasma membrane	protein binding			ovary(1)|lung(1)	2	Lung NSC(24;7.29e-29)|Breast(34;0.00211)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.161)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.171)			CTCCAGCTGTGATGAAGGCCC	0.567		NaN											0	0	0	0.001168	0	6	37									
APH1A	51107	broad.mit.edu	37	1	150240466	150240466	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:150240466C>T	uc001ety.1	-	2	497	c.175G>A	c.(175-177)GTG>ATG	p.V59M	APH1A_uc010pbx.1_Intron|APH1A_uc001etz.1_Missense_Mutation_p.V59M|APH1A_uc001eua.1_Missense_Mutation_p.V59M|APH1A_uc010pby.1_Intron|APH1A_uc001eub.1_Intron|APH1A_uc010pbz.1_Intron	NM_001077628	NP_001071096	Q96BI3	APH1A_HUMAN	anterior pharynx defective 1 homolog A isoform	59	Lumenal (Potential).				amyloid precursor protein catabolic process|apoptosis|induction of apoptosis by extracellular signals|membrane protein ectodomain proteolysis|membrane protein intracellular domain proteolysis|nerve growth factor receptor signaling pathway|Notch receptor processing|Notch signaling pathway|positive regulation of catalytic activity|protein processing	endoplasmic reticulum membrane|Golgi cisterna membrane|integral to plasma membrane	protein binding			ovary(1)|lung(1)	2	Lung NSC(24;7.29e-29)|Breast(34;0.00211)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.161)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.171)			CGGTCGGTCACATGGACCAAG	0.542		NaN											0	0	0	0.00632	0	29	49									
FLG	2312	broad.mit.edu	37	1	152281379	152281379	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:152281379C>G	uc001ezu.1	-	3	6019	c.5983G>C	c.(5983-5985)GAA>CAA	p.E1995Q		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	1995	Ser-rich.|Filaggrin 12.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CTTGCCTGTTCATGGGATGAC	0.567		NaN							Ichthyosis				0	0	0	0.01441	0	96	819									
FLG2	388698	broad.mit.edu	37	1	152327225	152327225	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:152327225C>T	uc001ezw.3	-	3	3110	c.3037G>A	c.(3037-3039)GGT>AGT	p.G1013S	uc001ezv.2_Intron	NM_001014342	NP_001014364	Q5D862	FILA2_HUMAN	filaggrin family member 2	1013	Ser-rich.						calcium ion binding|structural molecule activity			ovary(10)|skin(5)|upper_aerodigestive_tract(1)|breast(1)	17	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CCATGTTGACCATAGCCAGAT	0.483		NaN											0	0	0	0.01441	0	167	367									
KPRP	448834	broad.mit.edu	37	1	152732377	152732377	+	Missense_Mutation	SNP	T	T	C			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:152732377T>C	uc001fal.1	+	2	371	c.313T>C	c.(313-315)TCC>CCC	p.S105P		NM_001025231	NP_001020402	Q5T749	KPRP_HUMAN	keratinocyte proline-rich protein	105	Gln-rich.					cytoplasm				ovary(4)|pancreas(1)	5	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			ATCTCAAACTTCCTCTGTTCA	0.537		NaN											0	0	0	0.01441	0	115	274									
NUP210L	91181	broad.mit.edu	37	1	154000004	154000004	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:154000004G>A	uc001fdw.2	-	29	3997	c.3925C>T	c.(3925-3927)CAG>TAG	p.Q1309*	NUP210L_uc009woq.2_Nonsense_Mutation_p.Q218*|NUP210L_uc010peh.1_Nonsense_Mutation_p.Q1309*	NM_207308	NP_997191	Q5VU65	P210L_HUMAN	nucleoporin 210kDa-like isoform 1	1309						integral to membrane				skin(5)|ovary(4)|large_intestine(1)|central_nervous_system(1)	11	all_lung(78;9.35e-31)|Lung NSC(65;1.33e-28)|Hepatocellular(266;0.0877)|Melanoma(130;0.128)		LUSC - Lung squamous cell carcinoma(543;0.151)|Colorectal(543;0.198)			AGTTTGAGCTGAGAATTTATA	0.368		NaN											0	0	0	0.004289	0	36	101									
THBS3	7059	broad.mit.edu	37	1	155177629	155177629	+	Silent	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:155177629G>A	uc001fix.2	-	1	62	c.39C>T	c.(37-39)CTC>CTT	p.L13L	RAG1AP1_uc010pey.1_Intron|THBS3_uc009wqi.2_Silent_p.L13L|THBS3_uc001fiz.2_Silent_p.L13L|THBS3_uc001fiy.2_5'UTR|THBS3_uc010pfu.1_Silent_p.L13L|THBS3_uc010pfv.1_RNA|THBS3_uc001fja.2_Intron|THBS3_uc009wqj.1_Intron|MTX1_uc001fjb.2_5'Flank|MTX1_uc001fjc.2_5'Flank	NM_007112	NP_009043	P49746	TSP3_HUMAN	thrombospondin 3 precursor	13					cell-matrix adhesion	extracellular region|perinuclear region of cytoplasm	calcium ion binding|heparin binding|structural molecule activity			breast(3)|ovary(2)	5	all_epithelial(22;5.72e-28)|all_lung(78;2.07e-24)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		Epithelial(20;3.72e-10)|all cancers(21;1.19e-09)|BRCA - Breast invasive adenocarcinoma(34;0.000752)|LUSC - Lung squamous cell carcinoma(543;0.193)			AGCAAAGGAGGAGAAGAGCCA	0.607		NaN											0	0	0	0.006214	0	9	52									
RIT1	6016	broad.mit.edu	37	1	155880497	155880497	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:155880497G>A	uc001fmh.1	-	2	243	c.56C>T	c.(55-57)TCA>TTA	p.S19L	RIT1_uc010pgr.1_Intron	NM_006912	NP_008843	Q92963	RIT1_HUMAN	Ras-like without CAAX 1	19					nerve growth factor receptor signaling pathway|small GTPase mediated signal transduction	intracellular|plasma membrane	calmodulin binding|GTP binding|GTPase activity			breast(1)	1	Hepatocellular(266;0.133)|all_hematologic(923;0.145)|all_neural(408;0.195)		OV - Ovarian serous cystadenocarcinoma(3;1.79e-05)			GTACTCCCGTGAGAGCCCAGC	0.527		NaN											0	0	0	0.01441	0	43	138									
SEMA4A	64218	broad.mit.edu	37	1	156127890	156127890	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:156127890G>C	uc001fnl.2	+	4	434	c.330G>C	c.(328-330)AAG>AAC	p.K110N	SEMA4A_uc009wrq.2_Missense_Mutation_p.K110N|SEMA4A_uc001fnm.2_Missense_Mutation_p.K110N|SEMA4A_uc001fnn.2_Missense_Mutation_p.K11N|SEMA4A_uc001fno.2_Missense_Mutation_p.K110N	NM_022367	NP_071762	Q9H3S1	SEM4A_HUMAN	semaphorin B precursor	110	Sema.|Extracellular (Potential).				axon guidance	integral to membrane|plasma membrane	receptor activity			ovary(1)|skin(1)	2	Hepatocellular(266;0.158)					ACAGAAAAAAGAGTGAATGTG	0.522		NaN											0	0	0	0.010729	0	9	37									
ARHGEF11	9826	broad.mit.edu	37	1	156918212	156918212	+	Silent	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:156918212C>T	uc001fqo.2	-	22	2924	c.1884G>A	c.(1882-1884)GAG>GAA	p.E628E	ARHGEF11_uc010phu.1_Silent_p.E44E|ARHGEF11_uc001fqn.2_Silent_p.E668E|ARHGEF11_uc001fqp.1_Silent_p.E147E	NM_014784	NP_055599	O15085	ARHGB_HUMAN	Rho guanine nucleotide exchange factor (GEF) 11	628					actin cytoskeleton organization|apoptosis|axon guidance|cellular component movement|cytokinesis|establishment of cell polarity|G-protein coupled receptor protein signaling pathway|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|positive regulation of transcription, DNA-dependent|regulation of cell growth|regulation of Rho protein signal transduction|Rho protein signal transduction|striated muscle contraction	cytosol|Golgi apparatus|plasma membrane	G-protein-coupled receptor binding|GTPase activator activity|Rho guanyl-nucleotide exchange factor activity|signal transducer activity			ovary(3)|skin(2)|pleura(1)|lung(1)|kidney(1)|pancreas(1)	9	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					GGGGCACGTTCTCTGCCTTTC	0.602		NaN											0	0	0	0.006122	0	16	75									
SPTA1	6708	broad.mit.edu	37	1	158641938	158641938	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:158641938C>T	uc001fst.1	-	11	1598	c.1399G>A	c.(1399-1401)GAG>AAG	p.E467K		NM_003126	NP_003117	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1	467	Spectrin 5.				actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|breast(1)	8	all_hematologic(112;0.0378)					CGATGACGCTCGTCCCACAGT	0.423		NaN											0	0	0	0.00245	0	14	64									
OR6N2	81442	broad.mit.edu	37	1	158747226	158747226	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:158747226G>A	uc010pir.1	-	1	200	c.200C>T	c.(199-201)TCC>TTC	p.S67F		NM_001005278	NP_001005278	Q8NGY6	OR6N2_HUMAN	olfactory receptor, family 6, subfamily N,	67	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_hematologic(112;0.0378)					CTCCAAGAAGGAAAGAACACT	0.443		NaN											0	0	0	0.005443	0	28	211									
POGK	57645	broad.mit.edu	37	1	166818747	166818747	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:166818747C>G	uc001gdt.1	+	5	1051	c.931C>G	c.(931-933)CGA>GGA	p.R311G	POGK_uc010ple.1_Missense_Mutation_p.R226G|POGK_uc010plf.1_Missense_Mutation_p.R193G	NM_017542	NP_060012	Q9P215	POGK_HUMAN	pogo transposable element with KRAB domain	311	HTH CENPB-type.				multicellular organismal development|regulation of transcription, DNA-dependent	nucleus	DNA binding			ovary(1)	1						GGGTTGGTGTCGAAGAATGAT	0.547		NaN											0	0	0	0.003163	0	14	95									
ADCY10	55811	broad.mit.edu	37	1	167852770	167852770	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:167852770C>G	uc001ger.2	-	9	1223	c.925G>C	c.(925-927)GAG>CAG	p.E309Q	ADCY10_uc009wvk.2_Missense_Mutation_p.E217Q|ADCY10_uc010plj.1_Missense_Mutation_p.E156Q|ADCY10_uc009wvl.2_Missense_Mutation_p.E308Q|ADCY10_uc009wvm.2_RNA	NM_018417	NP_060887	Q96PN6	ADCYA_HUMAN	adenylate cyclase 10	309	Guanylate cyclase 2.				intracellular signal transduction|spermatogenesis	cytoskeleton|cytosol|perinuclear region of cytoplasm|plasma membrane|soluble fraction	adenylate cyclase activity|ATP binding|magnesium ion binding			central_nervous_system(2)|ovary(1)	3						GGGCCTATCTCTTCTGCTTTG	0.438		NaN											0	0	0	0.01441	0	54	207									
F5	2153	broad.mit.edu	37	1	169494148	169494148	+	Splice_Site	SNP	T	T	C			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:169494148T>C	uc001ggg.1	-	19	5862	c.5717_splice	c.e19-1	p.D1906_splice		NM_000130	NP_000121	P12259	FA5_HUMAN	coagulation factor V precursor						cell adhesion|platelet activation|platelet degranulation	plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity			ovary(3)|large_intestine(1)|central_nervous_system(1)|skin(1)	6	all_hematologic(923;0.208)				Drotrecogin alfa(DB00055)	TCCTACAGTCTATGAAAAACA	0.328		NaN											0	0	0	0.00623	0	40	91									
ZBTB37	84614	broad.mit.edu	37	1	173839578	173839578	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:173839578C>T	uc009wwp.1	+	3	491	c.215C>T	c.(214-216)TCA>TTA	p.S72L	GAS5_uc001gjj.2_5'Flank|GAS5_uc001gjk.2_5'Flank|SNORD74_uc001gjo.1_5'Flank|ZBTB37_uc001gjp.1_Missense_Mutation_p.S72L|ZBTB37_uc001gjq.3_Missense_Mutation_p.S72L|ZBTB37_uc001gjr.2_Missense_Mutation_p.S72L	NM_001122770	NP_001116242	Q5TC79	ZBT37_HUMAN	zinc finger and BTB domain containing 37 isoform	72	BTB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						GTCTCCATTTCAGTCATCAAG	0.483		NaN											0	0	0	0.00623	0	42	80									
DHX9	1660	broad.mit.edu	37	1	182822501	182822501	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:182822501G>A	uc001gpr.2	+	5	588	c.425G>A	c.(424-426)GGA>GAA	p.G142E	DHX9_uc001gps.2_5'UTR	NM_001357	NP_001348	Q08211	DHX9_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 9	142	Interaction with CREBBP.				CRD-mediated mRNA stabilization|nuclear mRNA splicing, via spliceosome	centrosome|CRD-mediated mRNA stability complex|nucleolus|nucleoplasm|ribonucleoprotein complex	ATP binding|ATP-dependent DNA helicase activity|ATP-dependent RNA helicase activity|DNA binding|double-stranded RNA binding|protein binding			ovary(2)	2						TGGGACCGAGGAGCCAACTTG	0.448		NaN											0	0	0	0.01441	0	48	142									
SMG7	9887	broad.mit.edu	37	1	183518386	183518386	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:183518386C>T	uc001gqg.2	+	18	2908	c.2786C>T	c.(2785-2787)TCC>TTC	p.S929F	SMG7_uc001gqf.2_Missense_Mutation_p.S933F|SMG7_uc001gqh.2_Missense_Mutation_p.S883F|SMG7_uc001gqi.2_Missense_Mutation_p.S841F|SMG7_uc010poc.1_Missense_Mutation_p.S937F	NM_173156	NP_775179	Q92540	SMG7_HUMAN	SMG-7 homolog isoform 1	929	Ser-rich.				mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of dephosphorylation	cytoplasm|intermediate filament cytoskeleton|nucleus	protein phosphatase 2A binding			upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	3						TCACATTCATCCTCTTTCCTG	0.388		NaN											0	0	0	0.005524	0	35	78									
HMCN1	83872	broad.mit.edu	37	1	186044020	186044020	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:186044020C>G	uc001grq.1	+	53	8516	c.8287C>G	c.(8287-8289)CAA>GAA	p.Q2763E		NM_031935	NP_114141	Q96RW7	HMCN1_HUMAN	hemicentin 1 precursor	2763	Ig-like C2-type 25.				response to stimulus|visual perception	basement membrane	calcium ion binding			ovary(22)|skin(1)	23						TGTGAATATTCAAGGTAATAC	0.284		NaN											0	0	0	0.014323	0	20	91									
ASPM	259266	broad.mit.edu	37	1	197070599	197070599	+	Silent	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:197070599C>T	uc001gtu.2	-	18	8039	c.7782G>A	c.(7780-7782)CAG>CAA	p.Q2594Q	ASPM_uc001gtv.2_Intron|ASPM_uc001gtw.3_Silent_p.Q442Q	NM_018136	NP_060606	Q8IZT6	ASPM_HUMAN	asp (abnormal spindle)-like, microcephaly	2594					mitosis	cytoplasm|nucleus	calmodulin binding			ovary(4)|central_nervous_system(2)	6						GAAATACTTTCTGTTTCTTTT	0.353		NaN											0	0	0	0.00499	0	18	86									
KDM5B	10765	broad.mit.edu	37	1	202718108	202718108	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:202718108C>T	uc001gyf.2	-	14	2097	c.1981G>A	c.(1981-1983)GAT>AAT	p.D661N	KDM5B_uc009xag.2_Missense_Mutation_p.D697N|KDM5B_uc001gyg.1_Missense_Mutation_p.D503N	NM_006618	NP_006609	Q9UGL1	KDM5B_HUMAN	jumonji, AT rich interactive domain 1B	661					negative regulation of transcription, DNA-dependent	nucleolus	DNA binding|histone demethylase activity (H3-dimethyl-K4 specific)|histone demethylase activity (H3-trimethyl-K4 specific)|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			ovary(2)|breast(2)|urinary_tract(1)	5						GCTTTCTCATCCTCAATCATA	0.388		NaN											0	0	0	0.011902	0	46	153									
CYB5R1	51706	broad.mit.edu	37	1	202935922	202935922	+	Silent	SNP	G	G	C			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:202935922G>C	uc001gyt.2	-	2	191	c.120C>G	c.(118-120)CTC>CTG	p.L40L	CYB5R1_uc010pqe.1_RNA	NM_016243	NP_057327	Q9UHQ9	NB5R1_HUMAN	cytochrome b5 reductase 1	40					sterol biosynthetic process	integral to membrane	cytochrome-b5 reductase activity			ovary(1)	1			BRCA - Breast invasive adenocarcinoma(75;0.141)			TGGGGTCCAGGAGAGTGACCT	0.632		NaN											0	0	0	0.001168	0	5	54									
LAX1	54900	broad.mit.edu	37	1	203743331	203743331	+	Missense_Mutation	SNP	A	A	G			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:203743331A>G	uc001haa.2	+	5	1129	c.719A>G	c.(718-720)GAC>GGC	p.D240G	LAX1_uc010pql.1_Missense_Mutation_p.D224G|LAX1_uc001hab.2_Missense_Mutation_p.D164G	NM_017773	NP_060243	Q8IWV1	LAX1_HUMAN	lymphocyte transmembrane adaptor 1 isoform a	240	Cytoplasmic (Potential).				B cell activation|immune response|inactivation of MAPK activity|intracellular signal transduction|negative regulation of T cell activation	Golgi apparatus|integral to membrane|plasma membrane	protein kinase binding|SH2 domain binding			central_nervous_system(2)	2	all_cancers(21;0.0915)		BRCA - Breast invasive adenocarcinoma(75;0.109)			GATGCTGGTGACTGCACCAGT	0.473		NaN											0	0	0	0.004656	0	24	44									
REN	5972	broad.mit.edu	37	1	204129688	204129688	+	Silent	SNP	G	G	C			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:204129688G>C	uc001haq.2	-	4	536	c.492C>G	c.(490-492)ACC>ACG	p.T164T		NM_000537	NP_000528	P00797	RENI_HUMAN	renin preproprotein	164					angiotensin maturation|regulation of MAPKKK cascade	extracellular space|membrane	aspartic-type endopeptidase activity			skin(3)|central_nervous_system(1)	4	all_cancers(21;0.00965)|Breast(84;0.116)|all_epithelial(62;0.157)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.109)		Aliskiren(DB01258)|Remikiren(DB00212)	CCCAACTTACGGTGATGATGT	0.597		NaN											0	0	0	0.001855	0	14	41									
PFKFB2	5208	broad.mit.edu	37	1	207228122	207228122	+	Silent	SNP	T	T	C			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:207228122T>C	uc001hfg.2	+	2	169	c.60T>C	c.(58-60)AAT>AAC	p.N20N	PFKFB2_uc010psc.1_5'UTR|YOD1_uc001hff.1_5'Flank|PFKFB2_uc001hfh.2_Silent_p.N20N|PFKFB2_uc009xcc.2_5'UTR	NM_006212	NP_006203	O60825	F262_HUMAN	6-phosphofructo-2-kinase/fructose-2,	20	6-phosphofructo-2-kinase.				fructose 2,6-bisphosphate metabolic process|glycolysis	cytosol	6-phosphofructo-2-kinase activity|ATP binding|fructose-2,6-bisphosphate 2-phosphatase activity			ovary(1)	1	Prostate(682;0.19)					AAACCCCAAATCTTCGAATGT	0.428		NaN											0	0	0	0.00308	0	7	30									
CD55	1604	broad.mit.edu	37	1	207495889	207495889	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:207495889C>T	uc001hfq.3	+	2	557	c.263C>T	c.(262-264)TCA>TTA	p.S88L	CD55_uc001hfp.3_Missense_Mutation_p.S88L|CD55_uc001hfr.3_Missense_Mutation_p.S88L|CD55_uc010psf.1_RNA|CD55_uc009xcf.2_Missense_Mutation_p.S88L|CD55_uc009xce.2_Missense_Mutation_p.S88L	NM_000574	NP_000565	P08174	DAF_HUMAN	decay accelerating factor for complement isoform	88	Sushi 1.				complement activation, classical pathway|elevation of cytosolic calcium ion concentration|innate immune response|respiratory burst	anchored to membrane|extracellular region|integral to plasma membrane|membrane raft|soluble fraction	receptor activity			ovary(1)	1					Chloramphenicol(DB00446)	AGTCAATGGTCAGATATTGAA	0.363		NaN											0	0	0	0.004878	0	35	79									
C1orf107	27042	broad.mit.edu	37	1	210010531	210010531	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:210010531G>A	uc001hhr.1	+	6	1113	c.1037G>A	c.(1036-1038)AGA>AAA	p.R346K	C1orf107_uc009xcu.1_Missense_Mutation_p.R61K	NM_014388	NP_055203	Q68CQ4	DIEXF_HUMAN	digestive-organ expansion factor homolog	346					multicellular organismal development	nucleus					0				OV - Ovarian serous cystadenocarcinoma(81;0.0367)		GATGACTTCAGAGACCAAGGG	0.522		NaN											0	0	0	0.009096	0	4	36									
LPGAT1	9926	broad.mit.edu	37	1	211966441	211966441	+	Silent	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:211966441C>T	uc001hiu.2	-	3	1143	c.330G>A	c.(328-330)CTG>CTA	p.L110L	LPGAT1_uc001hiv.2_Silent_p.L110L	NM_014873	NP_055688	Q92604	LGAT1_HUMAN	lysophosphatidylglycerol acyltransferase 1	110					phospholipid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	acyltransferase activity			ovary(1)|skin(1)	2				OV - Ovarian serous cystadenocarcinoma(81;0.00773)|all cancers(67;0.0765)|Epithelial(68;0.114)		GGCACATCATCAGTGTGCACA	0.403		NaN											0	0	0	0.01441	0	123	283									
FLVCR1	28982	broad.mit.edu	37	1	213032136	213032136	+	Silent	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:213032136C>T	uc001hjt.2	+	1	540	c.342C>T	c.(340-342)TTC>TTT	p.F114F	LQK1_uc001hjr.3_5'Flank|LQK1_uc001hjs.3_5'Flank	NM_014053	NP_054772	Q9Y5Y0	FLVC1_HUMAN	feline leukemia virus subgroup C cellular	114	Helical; (Potential).				cell death|cellular iron ion homeostasis|heme export|transmembrane transport	integral to plasma membrane	heme transporter activity|protein binding|receptor activity				0				OV - Ovarian serous cystadenocarcinoma(81;0.00733)|all cancers(67;0.013)|GBM - Glioblastoma multiforme(131;0.0845)|Epithelial(68;0.11)		TCCTGATCTTCAGCCTGTACT	0.637		NaN											0	0	0	0.012319	0	22	44									
RPS6KC1	26750	broad.mit.edu	37	1	213415370	213415370	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:213415370G>A	uc010ptr.1	+	11	2710	c.2551G>A	c.(2551-2553)GAT>AAT	p.D851N	RPS6KC1_uc001hkd.2_Missense_Mutation_p.D839N|RPS6KC1_uc010pts.1_Missense_Mutation_p.D639N|RPS6KC1_uc010ptt.1_Missense_Mutation_p.D639N|RPS6KC1_uc010ptu.1_Missense_Mutation_p.D670N|RPS6KC1_uc010ptv.1_Missense_Mutation_p.D386N|RPS6KC1_uc001hke.2_Missense_Mutation_p.D670N	NM_012424	NP_036556	Q96S38	KS6C1_HUMAN	ribosomal protein S6 kinase, 52kDa, polypeptide	851	Protein kinase 2.				cell communication|signal transduction	early endosome|membrane	ATP binding|phosphatidylinositol binding|protein binding|protein serine/threonine kinase activity			lung(4)|ovary(3)|breast(1)	8				OV - Ovarian serous cystadenocarcinoma(81;0.00705)|all cancers(67;0.016)|GBM - Glioblastoma multiforme(131;0.0663)|Epithelial(68;0.145)		AGATCAGACTGATGATTTGGC	0.383		NaN											0	0	0	0.01441	0	64	173									
TAF1A	9015	broad.mit.edu	37	1	222743964	222743964	+	Silent	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:222743964G>A	uc009xdz.1	-	6	837	c.648C>T	c.(646-648)TTC>TTT	p.F216F	TAF1A_uc001hni.1_Silent_p.F102F|TAF1A_uc001hnj.2_Silent_p.F216F|TAF1A_uc001hnk.2_Silent_p.F102F|TAF1A_uc010pur.1_Silent_p.F216F	NM_139352	NP_647603	Q15573	TAF1A_HUMAN	TBP-associated factor 1A isoform 2	216					regulation of transcription, DNA-dependent|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase I promoter	RNA polymerase I transcription factor complex	DNA binding				0				GBM - Glioblastoma multiforme(131;0.0186)		AGCTGTGGTTGAACACATCCT	0.363		NaN											0	0	0	0.01441	0	85	166									
OBSCN	84033	broad.mit.edu	37	1	228434453	228434453	+	Missense_Mutation	SNP	T	T	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:228434453T>A	uc009xez.1	+	13	4026	c.3982T>A	c.(3982-3984)TAC>AAC	p.Y1328N	OBSCN_uc001hsn.2_Missense_Mutation_p.Y1328N	NM_001098623	NP_001092093	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and	1328	Ig-like 13.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			stomach(8)|large_intestine(7)|breast(5)|ovary(4)|skin(2)|central_nervous_system(1)|pancreas(1)	28		Prostate(94;0.0405)				TGCTGGGGAGTACACCTGTGA	0.597		NaN											0	0	0	0.003755	0	31	68									
URB2	9816	broad.mit.edu	37	1	229771854	229771854	+	Silent	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:229771854C>T	uc001hts.1	+	4	1630	c.1494C>T	c.(1492-1494)CTC>CTT	p.L498L	URB2_uc009xfd.1_Silent_p.L498L	NM_014777	NP_055592	Q14146	URB2_HUMAN	URB2 ribosome biogenesis 2 homolog	498						nucleolus				central_nervous_system(2)|ovary(1)	3						CCACGGTACTCTCTGCATGCC	0.577		NaN											0	0	0	0.01441	0	62	127									
URB2	9816	broad.mit.edu	37	1	229772944	229772944	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:229772944G>A	uc001hts.1	+	4	2720	c.2584G>A	c.(2584-2586)GAA>AAA	p.E862K	URB2_uc009xfd.1_Missense_Mutation_p.E862K	NM_014777	NP_055592	Q14146	URB2_HUMAN	URB2 ribosome biogenesis 2 homolog	862						nucleolus				central_nervous_system(2)|ovary(1)	3						AGCTGGACCCGAAGGTATAGA	0.498		NaN											0	0	0	0.010504	0	21	144									
URB2	9816	broad.mit.edu	37	1	229773668	229773668	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:229773668C>T	uc001hts.1	+	4	3444	c.3308C>T	c.(3307-3309)TCA>TTA	p.S1103L	URB2_uc009xfd.1_Missense_Mutation_p.S1103L	NM_014777	NP_055592	Q14146	URB2_HUMAN	URB2 ribosome biogenesis 2 homolog	1103						nucleolus				central_nervous_system(2)|ovary(1)	3						CAGCTCTGCTCAGTGCCGGGG	0.647		NaN											0	0	0	0.010504	0	17	69									
COG2	22796	broad.mit.edu	37	1	230819378	230819378	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:230819378C>T	uc001htw.2	+	11	1376	c.1225C>T	c.(1225-1227)CCA>TCA	p.P409S	COG2_uc001htx.2_Missense_Mutation_p.P409S|COG2_uc010pwc.1_Missense_Mutation_p.P282S	NM_007357	NP_031383	Q14746	COG2_HUMAN	component of oligomeric golgi complex 2 isoform	409					Golgi organization|intra-Golgi vesicle-mediated transport|intracellular protein transport|oligosaccharide biosynthetic process|protein glycosylation	Golgi membrane|Golgi stack|Golgi transport complex	protein binding|protein transporter activity				0	Breast(184;0.0871)|Ovarian(103;0.183)	Prostate(94;0.178)				GGAAGATGCCCCAGGTAACTC	0.393		NaN											0	0	0	0.013114	0	42	91									
FMN2	56776	broad.mit.edu	37	1	240341299	240341299	+	Nonsense_Mutation	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:240341299C>T	uc010pyd.1	+	3	2086	c.1861C>T	c.(1861-1863)CGA>TGA	p.R621*	FMN2_uc010pye.1_Nonsense_Mutation_p.R621*	NM_020066	NP_064450	Q9NZ56	FMN2_HUMAN	formin 2	621					actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			ovary(4)|pancreas(3)|skin(3)|large_intestine(1)|central_nervous_system(1)	12	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			GTTTCCTAGGCGAGTTCCATC	0.448		NaN											0	0	0	0.007291	0	25	67									
EXO1	9156	broad.mit.edu	37	1	242048771	242048771	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:242048771C>G	uc001hzh.2	+	15	2907	c.2367C>G	c.(2365-2367)ATC>ATG	p.I789M	EXO1_uc001hzi.2_Missense_Mutation_p.I789M|EXO1_uc001hzj.2_Missense_Mutation_p.I789M|EXO1_uc009xgq.2_Missense_Mutation_p.I788M	NM_130398	NP_569082	Q9UQ84	EXO1_HUMAN	exonuclease 1 isoform b	789	Interaction with MLH1.|Interaction with MSH2.				meiosis|mismatch repair	nucleus	double-stranded DNA specific 5'-3' exodeoxyribonuclease activity|flap endonuclease activity|metal ion binding|protein binding|protein binding|ribonuclease H activity|single-stranded DNA specific 5'-3' exodeoxyribonuclease activity			ovary(2)|lung(2)|skin(1)	5	Ovarian(103;0.103)	all_cancers(173;0.0555)	OV - Ovarian serous cystadenocarcinoma(106;0.0107)			GGTTACAGATCAAACTCAATG	0.428		NaN						Direct_reversal_of_damage|Editing_and_processing_nucleases					0	0	0	0.00278	0	20	89									
ADSS	159	broad.mit.edu	37	1	244614999	244614999	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:244614999C>T	uc001iaj.2	-	1	415	c.121G>A	c.(121-123)GAA>AAA	p.E41K	C1orf101_uc001iak.1_5'Flank|ADSS_uc009xgr.1_RNA	NM_001126	NP_001117	P30520	PURA2_HUMAN	adenylosuccinate synthase	41	IMP binding (By similarity).|GTP.				AMP biosynthetic process|immune system process|purine base metabolic process	cytosol|plasma membrane	adenylosuccinate synthase activity|GTP binding|magnesium ion binding|phosphate binding			ovary(2)|kidney(1)	3	all_cancers(71;2.17e-05)|all_epithelial(71;0.00015)|all_neural(11;0.0269)|Breast(184;0.0654)|Glioma(6;0.0724)|Ovarian(71;0.0761)|all_lung(81;0.0874)|Lung NSC(105;0.121)	all_cancers(173;0.0896)|all_epithelial(177;0.172)	all cancers(7;9.71e-08)|GBM - Glioblastoma multiforme(7;1.28e-05)|OV - Ovarian serous cystadenocarcinoma(106;0.0014)		L-Aspartic Acid(DB00128)	CCTTTGCCTTCGTCGCCCCAC	0.736		NaN											0	0	0	0.000602	0	4	9									
OR2G2	81470	broad.mit.edu	37	1	247752506	247752506	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:247752506C>T	uc010pyy.1	+	1	845	c.845C>T	c.(844-846)ACT>ATT	p.T282I		NM_001001915	NP_001001915	Q8NGZ5	OR2G2_HUMAN	olfactory receptor, family 2, subfamily G,	282	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.017)			CTCTTCTACACTGTGGTAACC	0.348		NaN											0	0	0	0.01441	0	125	201									
SLC39A12	221074	broad.mit.edu	37	10	18331702	18331702	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr10:18331702G>C	uc001ipo.2	+	13	2289	c.2016G>C	c.(2014-2016)TTG>TTC	p.L672F	SLC39A12_uc001ipn.2_Missense_Mutation_p.L635F|SLC39A12_uc001ipp.2_Missense_Mutation_p.L671F|SLC39A12_uc010qck.1_Missense_Mutation_p.L538F	NM_001145195	NP_001138667	Q504Y0	S39AC_HUMAN	solute carrier family 39 (zinc transporter),	672	Helical; (Potential).				zinc ion transport	integral to membrane	metal ion transmembrane transporter activity			ovary(1)|breast(1)	2						ACTTTGGATTGATCCTAGGTT	0.338		NaN											0	0	0	0.003755	0	35	186									
CUL2	8453	broad.mit.edu	37	10	35317794	35317794	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr10:35317794G>A	uc001ixv.2	-	16	1771	c.1561C>T	c.(1561-1563)CAG>TAG	p.Q521*	CUL2_uc009xma.2_Nonsense_Mutation_p.Q390*|CUL2_uc010qer.1_Nonsense_Mutation_p.Q540*|CUL2_uc001ixw.2_Nonsense_Mutation_p.Q521*|CUL2_uc010qes.1_Nonsense_Mutation_p.Q458*	NM_003591	NP_003582	Q13617	CUL2_HUMAN	cullin 2	521					cell cycle arrest|G1/S transition of mitotic cell cycle|induction of apoptosis by intracellular signals|interspecies interaction between organisms|negative regulation of cell proliferation|ubiquitin-dependent protein catabolic process	cullin-RING ubiquitin ligase complex	ubiquitin protein ligase binding			ovary(3)	3						GAAGGAGCCTGAGTAAGAGGC	0.308		NaN											0	0	0	0.008871	0	19	35									
FZD8	8325	broad.mit.edu	37	10	35929518	35929518	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr10:35929518C>G	uc001iyz.1	-	1	845	c.840G>C	c.(838-840)TGG>TGC	p.W280C		NM_031866	NP_114072	Q9H461	FZD8_HUMAN	frizzled 8 precursor	280	Helical; Name=1; (Potential).				axonogenesis|brain development|canonical Wnt receptor signaling pathway|embryo development|gonad development|T cell differentiation in thymus|vasculature development	cell projection|Golgi apparatus|integral to membrane|plasma membrane	G-protein coupled receptor activity|PDZ domain binding|Wnt receptor activity|Wnt-protein binding				0						ACAGGCCGATCCAGAAGACGG	0.612		NaN											0	0	0	0.004672	0	3	45									
HNRNPF	3185	broad.mit.edu	37	10	43883236	43883236	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr10:43883236C>T	uc009xmh.1	-	3	584	c.97G>A	c.(97-99)GAC>AAC	p.D33N	HNRNPF_uc001jar.2_Missense_Mutation_p.D33N|HNRNPF_uc001jas.2_Missense_Mutation_p.D33N|HNRNPF_uc001jat.2_Missense_Mutation_p.D33N|HNRNPF_uc001jav.2_Missense_Mutation_p.D33N|HNRNPF_uc001jau.2_Missense_Mutation_p.D33N	NM_001098208	NP_001091678	P52597	HNRPF_HUMAN	heterogeneous nuclear ribonucleoprotein F	33	RRM 1.				regulation of RNA splicing	catalytic step 2 spliceosome|cytoplasm|heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	nucleotide binding|protein binding|single-stranded RNA binding				0						ATCGTGCAGTCAGAGAGGAAG	0.552		NaN											0	0	0	0.007413	0	20	79									
ZNF239	8187	broad.mit.edu	37	10	44052855	44052855	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr10:44052855G>A	uc001jaw.3	-	2	1326	c.673C>T	c.(673-675)CAT>TAT	p.H225Y	ZNF239_uc001jax.3_Missense_Mutation_p.H225Y|ZNF239_uc009xmj.2_Missense_Mutation_p.H225Y|ZNF239_uc009xmk.2_Missense_Mutation_p.H225Y	NM_005674	NP_005665	Q16600	ZN239_HUMAN	zinc finger protein 239	225	C2H2-type 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|RNA binding|zinc ion binding				0						TCTCTCTGATGAAGTAGTAGC	0.458		NaN											0	0	0	0.005443	0	28	223									
FRMPD2	143162	broad.mit.edu	37	10	49450206	49450206	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr10:49450206C>T	uc001jgi.2	-	5	672	c.565G>A	c.(565-567)GAG>AAG	p.E189K	FRMPD2_uc001jgh.2_Missense_Mutation_p.E158K|FRMPD2_uc001jgj.2_Missense_Mutation_p.E167K	NM_001018071	NP_001018081	Q68DX3	FRPD2_HUMAN	FERM and PDZ domain containing 2 isoform 3	189	KIND.				tight junction assembly	basolateral plasma membrane|cytoplasm|cytoskeleton|tight junction	1-phosphatidylinositol binding|protein binding			large_intestine(1)	1				Kidney(211;0.201)		CTACTGACCTCAGAAATGGTA	0.299		NaN											0	0	0	0.008871	0	19	139									
BICC1	80114	broad.mit.edu	37	10	60273078	60273078	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr10:60273078G>A	uc001jki.1	+	1	175	c.175G>A	c.(175-177)GAG>AAG	p.E59K		NM_001080512	NP_001073981	Q9H694	BICC1_HUMAN	bicaudal C homolog 1	59					multicellular organismal development		RNA binding			ovary(2)|lung(1)|skin(1)	4						GAAGAAACTTGAGGCCATGTT	0.657		NaN											0	0	0	0.012319	0	20	34									
HK1	3098	broad.mit.edu	37	10	71144211	71144211	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr10:71144211G>A	uc001jpl.3	+	11	1794	c.1693G>A	c.(1693-1695)GAA>AAA	p.E565K	HK1_uc001jpg.3_Missense_Mutation_p.E553K|HK1_uc001jph.3_Missense_Mutation_p.E569K|HK1_uc001jpi.3_Missense_Mutation_p.E569K|HK1_uc001jpj.3_Missense_Mutation_p.E600K|HK1_uc001jpk.3_Missense_Mutation_p.E564K|HK1_uc009xqd.2_Missense_Mutation_p.E443K	NM_000188	NP_000179	P19367	HXK1_HUMAN	hexokinase 1 isoform HKI	565	Catalytic.				glucose transport|glycolysis|transmembrane transport	cytosol|mitochondrial outer membrane|nucleus	ATP binding|glucokinase activity			ovary(1)	1						CATTCCTATTGAAATCATGCA	0.498		NaN											0	0	0	0.013726	0	34	91									
PRF1	5551	broad.mit.edu	37	10	72358051	72358051	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr10:72358051C>T	uc009xqg.2	-	3	1587	c.1426G>A	c.(1426-1428)GGG>AGG	p.G476R	PRF1_uc001jrf.3_Missense_Mutation_p.G476R	NM_001083116	NP_001076585	P14222	PERF_HUMAN	perforin 1 precursor	476	C2.				apoptosis|cellular defense response|cytolysis|defense response to tumor cell|defense response to virus|immune response to tumor cell|protein homooligomerization	cytolytic granule|endosome lumen|extracellular region|integral to membrane|plasma membrane	calcium ion binding|protein binding|wide pore channel activity			large_intestine(1)|ovary(1)|central_nervous_system(1)	3						CTCAGGGGCCCCCCTGTGGCC	0.607		NaN	M			various leukaemia|lymphoma	Type 2 familial hemophagocytic lymphohistiocytosis		Familial_Hemophagocytic_Lymphohistiocytosis				0	0	0	0.008361	0	29	82									
CAMK2G	818	broad.mit.edu	37	10	75609037	75609037	+	Silent	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr10:75609037G>A	uc001jvv.1	-	6	496	c.372C>T	c.(370-372)ATC>ATT	p.I124I	CAMK2G_uc001jvm.1_Silent_p.I132I|CAMK2G_uc001jvo.1_Silent_p.I132I|CAMK2G_uc001jvq.1_Silent_p.I132I|CAMK2G_uc001jvr.1_Silent_p.I132I|CAMK2G_uc001jvp.1_Silent_p.I132I|CAMK2G_uc001jvs.1_Silent_p.I132I|CAMK2G_uc001jvt.1_RNA|CAMK2G_uc001jvu.1_Silent_p.I110I|CAMK2G_uc010qkv.1_Intron	NM_172171	NP_751911	Q13555	KCC2G_HUMAN	calcium/calmodulin-dependent protein kinase II	132	Protein kinase.				insulin secretion|interferon-gamma-mediated signaling pathway|synaptic transmission	calcium- and calmodulin-dependent protein kinase complex|cytosol|endocytic vesicle membrane|nucleoplasm|plasma membrane	ATP binding|calcium-dependent protein serine/threonine phosphatase activity|calmodulin binding|calmodulin-dependent protein kinase activity			lung(1)|stomach(1)	2	Prostate(51;0.0112)					CCCTGTGGACGATGTCATGCT	0.522		NaN									OREG0020267	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.00308	0	6	23									
BTAF1	9044	broad.mit.edu	37	10	93719635	93719635	+	Missense_Mutation	SNP	G	G	A	rs112687582		TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr10:93719635G>A	uc001khr.2	+	10	1182	c.1084G>A	c.(1084-1086)GAA>AAA	p.E362K	BTAF1_uc009xua.1_RNA|BTAF1_uc001khs.1_Missense_Mutation_p.E32K	NM_003972	NP_003963	O14981	BTAF1_HUMAN	BTAF1 RNA polymerase II, B-TFIID transcription	362					negative regulation of transcription, DNA-dependent	nucleus	ATP binding|DNA binding|helicase activity|sequence-specific DNA binding transcription factor activity			ovary(1)|central_nervous_system(1)|skin(1)	3		Colorectal(252;0.0846)				TGTTTCTGATGAAGTAAGTAT	0.348		NaN											0	0	0	0.007835	0	41	80									
IDE	3416	broad.mit.edu	37	10	94267358	94267358	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr10:94267358G>C	uc001kia.2	-	9	1295	c.1219C>G	c.(1219-1221)CAA>GAA	p.Q407E		NM_004969	NP_004960	P14735	IDE_HUMAN	insulin-degrading enzyme isoform 1 precursor	407					beta-amyloid metabolic process|bradykinin catabolic process|interspecies interaction between organisms|sex differentiation	cell surface|extracellular space|soluble fraction	ATP binding|metalloendopeptidase activity|protein homodimerization activity|signal transducer activity|zinc ion binding			ovary(2)|central_nervous_system(1)	3					Bacitracin(DB00626)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	ACCCATTCTTGAGGTCCTTCT	0.328		NaN											0	0	0	0.013726	0	33	172									
EXOC6	54536	broad.mit.edu	37	10	94757311	94757311	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr10:94757311G>C	uc001kig.2	+	19	2100	c.2034G>C	c.(2032-2034)GAG>GAC	p.E678D	EXOC6_uc010qnr.1_Missense_Mutation_p.E694D|EXOC6_uc001kie.2_Missense_Mutation_p.E673D|EXOC6_uc009xub.2_Missense_Mutation_p.E677D|EXOC6_uc009xuc.2_Missense_Mutation_p.E575D|EXOC6_uc001kih.2_RNA|EXOC6_uc001kii.2_Missense_Mutation_p.E252D	NM_019053	NP_061926	Q8TAG9	EXOC6_HUMAN	SEC15-like 1 isoform a	678					protein transport|vesicle docking involved in exocytosis	exocyst				skin(1)	1		Colorectal(252;0.123)				TGGACAGTGAGTTAAAACAAA	0.368		NaN											0	0	0	0.006214	0	10	81									
ALDH18A1	5832	broad.mit.edu	37	10	97376261	97376261	+	Silent	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr10:97376261G>A	uc001kkz.2	-	13	1820	c.1578C>T	c.(1576-1578)ATC>ATT	p.I526I	ALDH18A1_uc001kky.2_Silent_p.I524I|ALDH18A1_uc010qog.1_Silent_p.I415I|ALDH18A1_uc010qoh.1_Silent_p.I314I	NM_002860	NP_002851	P54886	P5CS_HUMAN	pyrroline-5-carboxylate synthetase isoform 1	526	Gamma-glutamyl phosphate reductase.				proline biosynthetic process	mitochondrial inner membrane	ATP binding|glutamate 5-kinase activity|glutamate-5-semialdehyde dehydrogenase activity			pancreas(1)|central_nervous_system(1)|skin(1)	3		Colorectal(252;0.0402)		Epithelial(162;9.1e-07)|all cancers(201;2.55e-05)	L-Glutamic Acid(DB00142)	TGACTCCATGGATTGAGAGAG	0.547		NaN											0	0	0	0.009096	0	4	3									
DNTT	1791	broad.mit.edu	37	10	98078150	98078150	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr10:98078150C>T	uc001kmf.2	+	2	415	c.245C>T	c.(244-246)TCG>TTG	p.S82L	DNTT_uc001kmg.2_Missense_Mutation_p.S82L	NM_004088	NP_004079	P04053	TDT_HUMAN	terminal deoxynucleotidyltransferase isoform 1	82	BRCT.				DNA modification	nucleus	DNA binding|DNA nucleotidylexotransferase activity|DNA-directed DNA polymerase activity|metal ion binding			ovary(1)	1		Colorectal(252;0.0815)|all_hematologic(284;0.224)		Epithelial(162;7.97e-08)|all cancers(201;1.89e-06)		AACTCGGGTTCGGATGTTCTG	0.473		NaN											0	0	0	0.010771	0	42	251									
ARHGAP19	84986	broad.mit.edu	37	10	99023225	99023225	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr10:99023225C>T	uc001knb.2	-	4	594	c.565G>A	c.(565-567)GAG>AAG	p.E189K	ARHGAP19_uc001kmy.2_RNA|ARHGAP19_uc001kna.2_Missense_Mutation_p.E180K|ARHGAP19_uc009xvi.2_RNA|ARHGAP19_uc009xvj.2_Missense_Mutation_p.E189K|ARHGAP19_uc009xvk.2_Intron	NM_032900	NP_116289	Q14CB8	RHG19_HUMAN	Rho GTPase activating protein 19	189	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|nucleus	GTPase activator activity				0		Colorectal(252;0.0854)		Epithelial(162;7.65e-09)|all cancers(201;4.49e-07)		AGCAGAGGCTCCGGCAACTCT	0.403		NaN											0	0	0	0.01441	0	58	169									
ENTPD7	57089	broad.mit.edu	37	10	101445633	101445633	+	Silent	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr10:101445633G>A	uc001kqa.3	+	6	811	c.633G>A	c.(631-633)GTG>GTA	p.V211V	ENTPD7_uc009xwl.2_Silent_p.V213V	NM_020354	NP_065087	Q9NQZ7	ENTP7_HUMAN	ectonucleoside triphosphate diphosphohydrolase	211	Vesicular (Potential).					cytoplasmic vesicle membrane|integral to membrane	hydrolase activity			ovary(1)	1		Colorectal(252;0.234)		Epithelial(162;4.72e-10)|all cancers(201;3.75e-08)		AAGCAGAAGTGATCTCTGGGA	0.468		NaN											0	0	0	0.00623	0	39	57									
PDZD7	79955	broad.mit.edu	37	10	102777862	102777862	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr10:102777862C>T	uc001kso.1	-	9	1731	c.1516G>A	c.(1516-1518)GAG>AAG	p.E506K	PDZD7_uc001ksn.2_Missense_Mutation_p.E506K	NM_024895	NP_079171	Q9H5P4	PDZD7_HUMAN	PDZ domain containing 7	506						cilium|nucleus	protein binding			ovary(1)|breast(1)|central_nervous_system(1)	3				Epithelial(162;6.98e-09)|all cancers(201;3.55e-07)		TTACCTTTCTCTATGTCCAGG	0.418		NaN											0	0	0	0.010729	0	9	88									
FGF8	2253	broad.mit.edu	37	10	103531247	103531247	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr10:103531247C>T	uc001ktp.1	-	5	554	c.384G>A	c.(382-384)ATG>ATA	p.M128I	FGF8_uc001ktq.1_Missense_Mutation_p.M139I|FGF8_uc001ktr.1_Missense_Mutation_p.M110I|FGF8_uc001kts.1_Missense_Mutation_p.M99I|FGF8_uc009xwr.1_Missense_Mutation_p.M35I	NM_033164	NP_149354	P55075	FGF8_HUMAN	fibroblast growth factor 8 isoform E precursor	128					bone development|dopaminergic neuron differentiation|fibroblast growth factor receptor signaling pathway|gastrulation|gonad development|insulin receptor signaling pathway|mesonephros development|metanephros development|negative regulation of cardiac muscle tissue development|neuroepithelial cell differentiation|odontogenesis|positive regulation of cell division|positive regulation of cell proliferation	extracellular region|extracellular space	growth factor activity|growth factor activity|type 1 fibroblast growth factor receptor binding|type 2 fibroblast growth factor receptor binding				0		Colorectal(252;0.122)		Epithelial(162;3.94e-09)|all cancers(201;2.13e-07)		CCTTCTTGTTCATGCAGATGT	0.607		NaN											0	0	0	0.00499	0	16	30									
PPRC1	23082	broad.mit.edu	37	10	103900177	103900177	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr10:103900177G>A	uc001kum.2	+	5	1951	c.1912G>A	c.(1912-1914)GAC>AAC	p.D638N	PPRC1_uc001kun.2_Missense_Mutation_p.D518N|PPRC1_uc010qqj.1_Missense_Mutation_p.D638N|PPRC1_uc009xxa.2_RNA	NM_015062	NP_055877	Q5VV67	PPRC1_HUMAN	peroxisome proliferator-activated receptor	638					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleotide binding|RNA binding			ovary(1)|central_nervous_system(1)|skin(1)	3		Colorectal(252;0.122)		Epithelial(162;4.97e-08)|all cancers(201;8.99e-07)		AGTCCTGGCTGACTCAGCAGC	0.562		NaN											0	0	0	0.006122	0	18	69									
PPRC1	23082	broad.mit.edu	37	10	103900464	103900464	+	Silent	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr10:103900464G>A	uc001kum.2	+	5	2238	c.2199G>A	c.(2197-2199)CTG>CTA	p.L733L	PPRC1_uc001kun.2_Silent_p.L613L|PPRC1_uc010qqj.1_Silent_p.L733L|PPRC1_uc009xxa.2_RNA	NM_015062	NP_055877	Q5VV67	PPRC1_HUMAN	peroxisome proliferator-activated receptor	733					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleotide binding|RNA binding			ovary(1)|central_nervous_system(1)|skin(1)	3		Colorectal(252;0.122)		Epithelial(162;4.97e-08)|all cancers(201;8.99e-07)		TGGATTCTCTGAAAATTGAAA	0.547		NaN											0	0	0	0.008361	0	28	84									
PPRC1	23082	broad.mit.edu	37	10	103901412	103901412	+	Silent	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr10:103901412G>A	uc001kum.2	+	5	3186	c.3147G>A	c.(3145-3147)CAG>CAA	p.Q1049Q	PPRC1_uc001kun.2_Silent_p.Q929Q|PPRC1_uc010qqj.1_Silent_p.Q1049Q|PPRC1_uc009xxa.2_RNA	NM_015062	NP_055877	Q5VV67	PPRC1_HUMAN	peroxisome proliferator-activated receptor	1049	Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleotide binding|RNA binding			ovary(1)|central_nervous_system(1)|skin(1)	3		Colorectal(252;0.122)		Epithelial(162;4.97e-08)|all cancers(201;8.99e-07)		GAGCTCCTCAGACAGAGCCTA	0.582		NaN											0	0	0	0.009096	0	4	26									
LOC729020	729020	broad.mit.edu	37	10	105006301	105006301	+	Missense_Mutation	SNP	T	T	C			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr10:105006301T>C	uc009xxi.2	+	1	658	c.548T>C	c.(547-549)GTC>GCC	p.V183A	uc001kwr.2_Intron	NM_001143909	NP_001137381	Q2QD12	Q2QD12_HUMAN	rcRPE protein	183					carbohydrate metabolic process		ribulose-phosphate 3-epimerase activity				0						TCTGACACTGTCCATAAGTGT	0.448		NaN											0	0	0	0.010504	0	22	51									
C10orf79	80217	broad.mit.edu	37	10	105990389	105990389	+	Missense_Mutation	SNP	A	A	G			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr10:105990389A>G	uc001kxw.2	-	2	394	c.278T>C	c.(277-279)GTA>GCA	p.V93A	C10orf79_uc001kxx.3_Missense_Mutation_p.V93A|C10orf79_uc001kxy.1_Missense_Mutation_p.V93A|C10orf79_uc001kxz.2_Missense_Mutation_p.V93A	NM_025145	NP_079421	Q8NDM7	WDR96_HUMAN	hypothetical protein LOC80217	93											0		Colorectal(252;0.178)		Epithelial(162;4.83e-10)|all cancers(201;2.26e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0194)		AAAGCTGTATACGTAGATGAG	0.428		NaN											0	0	0	0.01441	0	51	103									
ADRA2A	150	broad.mit.edu	37	10	112839122	112839122	+	Silent	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr10:112839122C>T	uc001kzo.2	+	1	2333	c.1368C>T	c.(1366-1368)CTC>CTT	p.L456L		NM_000681	NP_000672	P08913	ADA2A_HUMAN	alpha-2A-adrenergic receptor	441	Cytoplasmic (By similarity).				actin cytoskeleton organization|activation of MAPK activity by adrenergic receptor signaling pathway|activation of phospholipase C activity by adrenergic receptor signaling pathway|activation of protein kinase B activity|blood coagulation|cellular component movement|cellular response to hormone stimulus|energy reserve metabolic process|epidermal growth factor receptor transactivation by G-protein coupled receptor signaling pathway|glucose homeostasis|inhibition of adenylate cyclase activity by adrenergic receptor signaling pathway|intestinal absorption|negative regulation of adrenergic receptor signaling pathway|negative regulation of calcium ion transport via voltage-gated calcium channel activity|negative regulation of cAMP biosynthetic process|negative regulation of epinephrine secretion|negative regulation of insulin secretion involved in cellular response to glucose stimulus|negative regulation of lipid catabolic process|negative regulation of norepinephrine secretion|positive regulation of cell migration|positive regulation of cell proliferation|positive regulation of cytokine production|positive regulation of membrane protein ectodomain proteolysis|positive regulation of potassium ion transport|positive regulation of wound healing|Rho protein signal transduction	basolateral plasma membrane|cytoplasm|integral to plasma membrane|receptor complex	alpha-1B adrenergic receptor binding|alpha-2C adrenergic receptor binding|alpha2-adrenergic receptor activity|epinephrine binding|heterotrimeric G-protein binding|norepinephrine binding|protein heterodimerization activity|protein homodimerization activity|protein kinase binding|thioesterase binding				0		Breast(234;0.0735)|Lung NSC(174;0.238)		Epithelial(162;0.000316)|all cancers(201;0.00501)|BRCA - Breast invasive adenocarcinoma(275;0.118)	Amitriptyline(DB00321)|Amphetamine(DB00182)|Apraclonidine(DB00964)|Benzphetamine(DB00865)|Bethanidine(DB00217)|Brimonidine(DB00484)|Clonidine(DB00575)|Debrisoquin(DB04840)|Dexmedetomidine(DB00633)|Dipivefrin(DB00449)|Epinastine(DB00751)|Ergotamine(DB00696)|Fenoldopam(DB00800)|Guanabenz(DB00629)|Guanadrel Sulfate(DB00226)|Guanethidine(DB01170)|Guanfacine(DB01018)|Lofexidine(DB04948)|Methyldopa(DB00968)|Mianserin(DB06148)|Mirtazapine(DB00370)|Norepinephrine(DB00368)|Oxymetazoline(DB00935)|Phentolamine(DB00692)|Phenylpropanolamine(DB00397)|Pseudoephedrine(DB00852)|Tizanidine(DB00697)|Trazodone(DB00656)|Yohimbine(DB01392)	AGAAGATCCTCTGTCGGGGGG	0.592		NaN											0	0	0	0.004007	0	14	77									
TACC2	10579	broad.mit.edu	37	10	123844346	123844346	+	Silent	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr10:123844346G>A	uc001lfv.2	+	4	2691	c.2331G>A	c.(2329-2331)GGG>GGA	p.G777G	TACC2_uc001lfw.2_Intron|TACC2_uc009xzx.2_Silent_p.G777G|TACC2_uc010qtv.1_Silent_p.G777G	NM_206862	NP_996744	O95359	TACC2_HUMAN	transforming, acidic coiled-coil containing	777						microtubule organizing center|nucleus	nuclear hormone receptor binding			ovary(4)|breast(3)|skin(2)|central_nervous_system(1)	10		all_neural(114;0.0656)|Lung NSC(174;0.136)|all_lung(145;0.17)|Breast(234;0.197)				TTCATGCTGGGGTGCCACATC	0.632		NaN											0	0	0	0.009718	0	40	64									
DOCK1	1793	broad.mit.edu	37	10	129245729	129245729	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr10:129245729G>A	uc001ljt.2	+	51	5486	c.5422G>A	c.(5422-5424)GTG>ATG	p.V1808M	DOCK1_uc010qun.1_Missense_Mutation_p.V1829M|DOCK1_uc009yaq.2_Missense_Mutation_p.R807H|DOCK1_uc001ljw.1_5'Flank	NM_001380	NP_001371	Q14185	DOCK1_HUMAN	dedicator of cytokinesis 1	1808	Interaction with NCK2 second and third SH3 domain (minor).				apoptosis|axon guidance|blood coagulation|integrin-mediated signaling pathway|phagocytosis, engulfment|small GTPase mediated signal transduction	cytosol|membrane	GTP binding|GTPase activator activity|GTPase binding|guanyl-nucleotide exchange factor activity|SH3 domain binding			central_nervous_system(4)|ovary(2)|lung(1)|breast(1)|kidney(1)	9		all_epithelial(44;2.3e-07)|all_lung(145;0.00466)|Lung NSC(174;0.00685)|Colorectal(57;0.0107)|Renal(717;0.0113)|Breast(234;0.0492)|all_neural(114;0.108)|all_hematologic(284;0.14)		BRCA - Breast invasive adenocarcinoma(275;0.0221)|Colorectal(40;0.115)		CAAAGGCAGCGTGGCAGATTA	0.572		NaN											0	0	0	0.00308	0	7	15									
MKI67	4288	broad.mit.edu	37	10	129913744	129913744	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr10:129913744C>T	uc001lke.2	-	7	1123	c.928G>A	c.(928-930)GAA>AAA	p.E310K	MKI67_uc001lkf.2_Intron|MKI67_uc009yav.1_Intron|MKI67_uc009yaw.1_Intron	NM_002417	NP_002408	P46013	KI67_HUMAN	antigen identified by monoclonal antibody Ki-67	310					cell proliferation	nucleolus	ATP binding|protein C-terminus binding			ovary(4)|central_nervous_system(2)|skin(1)	7		all_epithelial(44;2.12e-05)|all_lung(145;0.00679)|Lung NSC(174;0.00998)|all_neural(114;0.0936)|Colorectal(57;0.14)|Breast(234;0.166)|Melanoma(40;0.203)				AGCTCTTGTTCAGGTGAAGCA	0.572		NaN											0	0	0	0.014323	0	22	110									
PWWP2B	170394	broad.mit.edu	37	10	134219559	134219559	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr10:134219559G>A	uc001lll.3	+	2	1584	c.1555G>A	c.(1555-1557)GGA>AGA	p.G519R	PWWP2B_uc009ybe.2_Intron	NM_138499	NP_612508	Q6NUJ5	PWP2B_HUMAN	PWWP domain containing 2 isoform 1	519	PWWP.										0		all_cancers(35;6.69e-12)|all_epithelial(44;1.55e-08)|Lung NSC(174;0.000845)|all_lung(145;0.00144)|all_neural(114;0.0299)|Breast(234;0.106)|Colorectal(31;0.109)|Melanoma(40;0.123)|Glioma(114;0.203)|all_hematologic(284;0.224)		OV - Ovarian serous cystadenocarcinoma(35;7.49e-05)|Epithelial(32;0.00016)|all cancers(32;0.000186)		GAAGGAGGACGGAGAGCCGTC	0.537		NaN											0	0	0	0.004007	0	16	84									
MTG1	92170	broad.mit.edu	37	10	135213089	135213089	+	Silent	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr10:135213089C>T	uc001lnd.2	+	6	581	c.477C>T	c.(475-477)CTC>CTT	p.L159L	MTG1_uc010qve.1_Intron	NM_138384	NP_612393	Q9BT17	MTG1_HUMAN	GTP_binding protein precursor	159	G.					mitochondrion	GTP binding|protein binding			skin(1)	1		all_cancers(35;1.14e-09)|all_epithelial(44;5.79e-08)|Lung NSC(174;0.00263)|all_lung(145;0.0039)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.172)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;1.21e-06)|all cancers(32;1.69e-06)|Epithelial(32;1.94e-06)		AGTCCTCCCTCATCAACTCCC	0.622		NaN											0	0	0	0.005443	0	27	55									
MUC6	4588	broad.mit.edu	37	11	1025893	1025893	+	Nonsense_Mutation	SNP	G	G	C			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr11:1025893G>C	uc001lsw.2	-	22	2762	c.2711C>G	c.(2710-2712)TCA>TGA	p.S904*		NM_005961	NP_005952	Q6W4X9	MUC6_HUMAN	mucin 6, gastric	904	VWFD 3.				maintenance of gastrointestinal epithelium	extracellular region	extracellular matrix structural constituent			ovary(1)	1		all_cancers(49;3.3e-08)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		all cancers(45;1.24e-24)|BRCA - Breast invasive adenocarcinoma(625;0.00031)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)		GGTGGGCTGTGAGTCGTTGAC	0.652		NaN											0	0	0	0.001168	0	6	17									
OR51A7	119687	broad.mit.edu	37	11	4928820	4928821	+	Missense_Mutation	DNP	CC	CC	TT			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr11:4928820_4928821CC>TT	uc010qyq.1	+	1	221_222	c.221_222CC>TT	c.(220-222)TCC>TTT	p.S74F		NM_001004749	NP_001004749	Q8NH64	O51A7_HUMAN	olfactory receptor, family 51, subfamily A,	74	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;4.77e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00435)|LUSC - Lung squamous cell carcinoma(625;0.19)		ATGGGCCTGTCCCTCTCCTCCC	0.46		NaN											0	0	0	0.004672	0	7	176									
OR51Q1	390061	broad.mit.edu	37	11	5444186	5444186	+	Silent	SNP	C	C	G			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr11:5444186C>G	uc010qzd.1	+	1	756	c.756C>G	c.(754-756)GTC>GTG	p.V252V	HBG2_uc001mak.1_Intron|HBE1_uc001mam.1_Intron|OR51B5_uc001maq.1_Intron	NM_001004757	NP_001004757	Q8NH59	O51Q1_HUMAN	olfactory receptor, family 51, subfamily Q,	252	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;2.18e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CTGTCCTGGTCCTCTACATTC	0.502		NaN											0	0	0	0.006122	0	16	110									
SMPD1	6609	broad.mit.edu	37	11	6412757	6412757	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr11:6412757C>G	uc001mcw.2	+	2	636	c.462C>G	c.(460-462)AGC>AGG	p.S154R	SMPD1_uc001mcv.1_Intron|SMPD1_uc009yex.2_RNA|SMPD1_uc001mcx.2_Missense_Mutation_p.S154R|SMPD1_uc009yew.2_Missense_Mutation_p.S153R	NM_000543	NP_000534	P17405	ASM_HUMAN	sphingomyelin phosphodiesterase 1, acid	152	Saposin B-type.				cell death|ceramide biosynthetic process|negative regulation of MAP kinase activity|nervous system development|positive regulation of protein dephosphorylation|signal transduction|sphingomyelin catabolic process|termination of signal transduction	lysosome	hydrolase activity, acting on glycosyl bonds|sphingomyelin phosphodiesterase activity				0		Medulloblastoma(188;0.00263)|all_neural(188;0.026)|Breast(177;0.029)		Epithelial(150;4.9e-08)|BRCA - Breast invasive adenocarcinoma(625;0.189)	Desipramine(DB01151)	CAGTGCTGAGCCCATCTGAGG	0.572		NaN											0	0	0	0.004007	0	16	23									
APBB1	322	broad.mit.edu	37	11	6432430	6432430	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr11:6432430G>C	uc001mdb.1	-	2	248	c.148C>G	c.(148-150)CTG>GTG	p.L50V	APBB1_uc001mdc.1_Missense_Mutation_p.L50V|APBB1_uc010rah.1_Intron	NM_001164	NP_001155	O00213	APBB1_HUMAN	amyloid beta A4 precursor protein-binding,	50					apoptosis|axonogenesis|cell cycle arrest|histone H4 acetylation|negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|negative regulation of thymidylate synthase biosynthetic process|positive regulation of apoptosis|positive regulation of transcription, DNA-dependent|response to DNA damage stimulus|signal transduction|transcription, DNA-dependent	cytoplasm|growth cone|lamellipodium|nucleus|plasma membrane|synapse	beta-amyloid binding|chromatin binding|histone binding|proline-rich region binding|transcription factor binding			breast(2)	2		Medulloblastoma(188;0.00263)|all_neural(188;0.026)|Breast(177;0.029)		Epithelial(150;6.49e-08)|BRCA - Breast invasive adenocarcinoma(625;0.194)		GCGCTGCGCAGGTCCTTGGGT	0.697		NaN											0	0	0	0.006122	0	18	114									
OR10A2	341276	broad.mit.edu	37	11	6891489	6891489	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr11:6891489C>A	uc001meu.1	+	1	504	c.504C>A	c.(502-504)AGC>AGA	p.S168R		NM_001004460	NP_001004460	Q9H208	O10A2_HUMAN	olfactory receptor, family 10, subfamily A,	168	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)	1		Medulloblastoma(188;0.0523)|all_neural(188;0.236)		Epithelial(150;4.89e-08)|BRCA - Breast invasive adenocarcinoma(625;0.13)		TCTGTGACAGCCCACCTGTGC	0.532		NaN											1	0	1.10923e-09	0.00278	1.14699e-09	19	185									
SBF2	81846	broad.mit.edu	37	11	9806738	9806738	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr11:9806738G>A	uc001mib.2	-	37	5303	c.5165C>T	c.(5164-5166)TCC>TTC	p.S1722F	uc001mhz.1_Intron|SBF2_uc001mid.2_Missense_Mutation_p.S366F|SBF2_uc001mic.2_Missense_Mutation_p.S12F|uc001mie.3_Intron	NM_030962	NP_112224	Q86WG5	MTMRD_HUMAN	SET binding factor 2	1722					myelination	cytoplasm|membrane	phosphatase activity|protein binding			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3				all cancers(16;2.88e-11)|Epithelial(150;3.61e-10)|BRCA - Breast invasive adenocarcinoma(625;0.00887)		CACTCCATTGGATGGGGAGAT	0.507		NaN											0	0	0	0.013537	0	13	66									
MICAL2	9645	broad.mit.edu	37	11	12278388	12278388	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr11:12278388C>G	uc001mjz.2	+	24	3300	c.3012C>G	c.(3010-3012)TTC>TTG	p.F1004L	MICAL2_uc010rch.1_Missense_Mutation_p.F814L|MICAL2_uc001mka.2_Missense_Mutation_p.F1004L|MICAL2_uc010rci.1_Missense_Mutation_p.F983L|MICAL2_uc001mkb.2_Missense_Mutation_p.F778L|MICAL2_uc001mkc.2_Missense_Mutation_p.F757L|MICAL2_uc001mkd.2_Missense_Mutation_p.F586L|MICAL2_uc010rcj.1_Missense_Mutation_p.F216L|MICAL2_uc001mkf.2_RNA	NM_014632	NP_055447	O94851	MICA2_HUMAN	microtubule associated monoxygenase, calponin	1004	LIM zinc-binding.					cytoplasm|cytoskeleton	monooxygenase activity|zinc ion binding			upper_aerodigestive_tract(2)	2				Epithelial(150;0.00552)		CGTGTTACTTCTGTAAGAAAC	0.557		NaN											0	0	0	0.006214	0	10	49									
PRRG4	79056	broad.mit.edu	37	11	32858272	32858272	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr11:32858272G>C	uc001mtx.2	+	3	425	c.172G>C	c.(172-174)GAG>CAG	p.E58Q		NM_024081	NP_076986	Q9BZD6	TMG4_HUMAN	proline rich Gla (G-carboxyglutamic acid) 4	58	Extracellular (Potential).|Gla.					extracellular region|Golgi apparatus|integral to membrane	calcium ion binding				0	Breast(20;0.206)					ATTTGATCTGGAGCTCTTCAC	0.348		NaN											0	0	0	0.00245	0	15	67									
TRIM44	54765	broad.mit.edu	37	11	35684687	35684687	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr11:35684687G>A	uc001mwi.2	+	1	335	c.28G>A	c.(28-30)GAG>AAG	p.E10K		NM_017583	NP_060053	Q96DX7	TRI44_HUMAN	DIPB protein	10						intracellular	protein binding|zinc ion binding			skin(1)	1	all_lung(20;0.0317)|Lung NSC(22;0.0661)|all_epithelial(35;0.115)	all_hematologic(20;0.107)				CGCGGCCTTCGAGGAACTGCC	0.716		NaN											0	0	0	0.00308	0	6	19									
LRRC4C	57689	broad.mit.edu	37	11	40137629	40137629	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr11:40137629C>T	uc001mxa.1	-	2	2178	c.214G>A	c.(214-216)GAT>AAT	p.D72N	LRRC4C_uc001mxc.1_Missense_Mutation_p.D68N|LRRC4C_uc001mxd.1_Missense_Mutation_p.D68N|LRRC4C_uc001mxb.1_Missense_Mutation_p.D68N	NM_020929	NP_065980	Q9HCJ2	LRC4C_HUMAN	netrin-G1 ligand precursor	72	LRRNT.				regulation of axonogenesis	integral to membrane	protein binding			ovary(4)|skin(3)|central_nervous_system(1)	8		all_lung(304;0.0575)|Lung NSC(402;0.138)				GAGATGCCATCCGGAACCTCA	0.527		NaN											0	0	0	0.003954	0	24	46									
OR4A47	403253	broad.mit.edu	37	11	48510885	48510885	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr11:48510885C>G	uc010rhx.1	+	1	541	c.541C>G	c.(541-543)CCC>GCC	p.P181A		NM_001005512	NP_001005512	Q6IF82	O4A47_HUMAN	olfactory receptor, family 4, subfamily A,	181	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.P181L(1)		ovary(1)|skin(1)	2						TGACATGTATCCCTTATTGAA	0.443		NaN											0	0	0	0.00245	0	15	280									
TMX2	51075	broad.mit.edu	37	11	57506699	57506699	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr11:57506699G>C	uc001nlc.1	+	7	760	c.711G>C	c.(709-711)AAG>AAC	p.K237N	CTNND1_uc001nlf.1_Intron|TMX2_uc001nld.1_Missense_Mutation_p.K143N|TMX2_uc001nle.1_Missense_Mutation_p.K199N|C11orf31_uc010rjx.1_5'Flank	NM_015959	NP_057043	Q9Y320	TMX2_HUMAN	thioredoxin domain containing 14 isoform 1	237	Cytoplasmic (Potential).|Thioredoxin.				cell redox homeostasis	integral to membrane					0						AGATTGACAAGAAAGGACGGG	0.453		NaN											0	0	0	0.00499	0	16	110									
OR6Q1	219952	broad.mit.edu	37	11	57798494	57798494	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr11:57798494G>A	uc010rjz.1	+	1	70	c.70G>A	c.(70-72)GAA>AAA	p.E24K	OR9Q1_uc001nmj.2_Intron	NM_001005186	NP_001005186	Q8NGQ2	OR6Q1_HUMAN	olfactory receptor, family 6, subfamily Q,	24	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			kidney(1)	1		Breast(21;0.0707)|all_epithelial(135;0.142)				TGGCATCCATGAAGCACACCT	0.468		NaN											0	0	0	0.01441	0	111	305									
LPXN	9404	broad.mit.edu	37	11	58322349	58322349	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr11:58322349C>T	uc001nmw.2	-	4	428	c.283G>A	c.(283-285)GAG>AAG	p.E95K	LPXN_uc009ymp.2_5'UTR|LPXN_uc010rkj.1_Missense_Mutation_p.E100K|LPXN_uc010rkk.1_Missense_Mutation_p.E75K	NM_004811	NP_004802	O60711	LPXN_HUMAN	leupaxin isoform 2	95	LD motif 3.				cell adhesion|protein complex assembly|signal transduction	cytoplasm	zinc ion binding			ovary(1)	1		Breast(21;0.00725)|all_epithelial(135;0.0101)|all_lung(304;0.24)				GCCATGAGCTCATCCAACTGA	0.498		NaN											0	0	0	0.000602	0	4	61									
GLYAT	10249	broad.mit.edu	37	11	58478139	58478139	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr11:58478139C>T	uc001nnb.2	-	5	567	c.412G>A	c.(412-414)GAA>AAA	p.E138K	GLYAT_uc001nnc.2_Missense_Mutation_p.E138K	NM_201648	NP_964011	Q6IB77	GLYAT_HUMAN	glycine-N-acyltransferase isoform a	138					acyl-CoA metabolic process|response to toxin|xenobiotic metabolic process	mitochondrial matrix	glycine N-acyltransferase activity|glycine N-benzoyltransferase activity				0		Breast(21;0.0044)|all_epithelial(135;0.0157)			Glycine(DB00145)	TTGGCTGTTTCAGCTGCCATA	0.423		NaN											0	0	0	0.013114	0	39	199									
MPEG1	219972	broad.mit.edu	37	11	58978821	58978821	+	Silent	SNP	G	G	C			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr11:58978821G>C	uc001nnu.3	-	1	1674	c.1518C>G	c.(1516-1518)CTC>CTG	p.L506L		NM_001039396	NP_001034485	Q2M385	MPEG1_HUMAN	macrophage expressed gene 1 precursor	506	Extracellular (Potential).					integral to membrane				ovary(1)|skin(1)	2		all_epithelial(135;0.125)				GGTTTTCAAAGAGTCTCAGTG	0.512		NaN											0	0	0	0.008871	0	19	97									
OSBP	5007	broad.mit.edu	37	11	59349008	59349008	+	Silent	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr11:59349008G>A	uc001noc.1	-	10	2178	c.1698C>T	c.(1696-1698)TTC>TTT	p.F566F	OSBP_uc009ymr.1_RNA	NM_002556	NP_002547	P22059	OSBP1_HUMAN	oxysterol binding protein	566					lipid transport	Golgi membrane	oxysterol binding			large_intestine(1)	1		all_epithelial(135;0.000236)		BRCA - Breast invasive adenocarcinoma(625;0.00607)|LUSC - Lung squamous cell carcinoma(625;0.207)		CAGTTGCATGGAAAATACAAT	0.413		NaN											0	0	0	0.008871	0	21	149									
MS4A1	931	broad.mit.edu	37	11	60229875	60229875	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr11:60229875G>A	uc001npp.2	+	3	444	c.28G>A	c.(28-30)GGG>AGG	p.G10R	MS4A1_uc009ymy.1_Missense_Mutation_p.G10R|MS4A1_uc001npq.2_Missense_Mutation_p.G10R|MS4A1_uc009yna.2_Missense_Mutation_p.G10R|MS4A1_uc009ymz.2_Missense_Mutation_p.G10R|MS4A1_uc010rlc.1_Missense_Mutation_p.G10R	NM_152866	NP_690605	P11836	CD20_HUMAN	membrane-spanning 4-domains, subfamily A, member	10	Cytoplasmic (Potential).				B cell activation|immune response	integral to plasma membrane				ovary(3)|lung(2)	5					Ibritumomab(DB00078)|Rituximab(DB00073)|Tositumomab(DB00081)	TTCAGTAAATGGGACTTTCCC	0.433		NaN											0	0	0	0.00623	0	36	85									
EEF1G	1937	broad.mit.edu	37	11	62334336	62334336	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr11:62334336C>T	uc001ntm.1	-	7	945	c.799G>A	c.(799-801)GAG>AAG	p.E267K	EEF1G_uc010rlw.1_Missense_Mutation_p.E317K|EEF1G_uc001ntn.1_Missense_Mutation_p.E147K	NM_001404	NP_001395	P26641	EF1G_HUMAN	eukaryotic translation elongation factor 1	267					response to virus	cytosol|eukaryotic translation elongation factor 1 complex	protein binding|translation elongation factor activity				0						AGCGCCTGCTCACATTCATCC	0.602		NaN											0	0	0	0.010818	0	31	53									
HRASLS5	117245	broad.mit.edu	37	11	63235859	63235859	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr11:63235859C>A	uc001nwy.2	-	4	628	c.454G>T	c.(454-456)GAT>TAT	p.D152Y	HRASLS5_uc001nwz.2_Missense_Mutation_p.D142Y|HRASLS5_uc010rmq.1_Missense_Mutation_p.D152Y|HRASLS5_uc009yos.2_Intron	NM_054108	NP_473449	Q96KN8	HRSL5_HUMAN	HRAS-like suppressor family, member 5 isoform 1	152										ovary(1)	1						ACGCAATCATCTTCTACATAG	0.388		NaN											1	0	1.13719e-10	0.008361	1.18005e-10	29	192									
ATG2A	23130	broad.mit.edu	37	11	64668054	64668054	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr11:64668054G>C	uc001obx.2	-	31	4491	c.4376C>G	c.(4375-4377)TCT>TGT	p.S1459C	ATG2A_uc001obw.2_Missense_Mutation_p.S224C	NM_015104	NP_055919	Q2TAZ0	ATG2A_HUMAN	autophagy related 2A	1459							protein binding			ovary(1)|central_nervous_system(1)	2						GTTGGGGCCAGAGCAGCGGGA	0.667		NaN											0	0	0	0.008291	0	10	45									
RELA	5970	broad.mit.edu	37	11	65421919	65421919	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr11:65421919G>A	uc001ofg.2	-	11	1726	c.1586C>T	c.(1585-1587)TCA>TTA	p.S529L	RELA_uc001ofh.2_Missense_Mutation_p.S526L|RELA_uc010ron.1_Missense_Mutation_p.S540L|RELA_uc009yqr.2_Missense_Mutation_p.S476L|RELA_uc001ofe.2_3'UTR|RELA_uc001off.2_Missense_Mutation_p.S426L	NM_021975	NP_068810	Q04206	TF65_HUMAN	v-rel reticuloendotheliosis viral oncogene	529					anti-apoptosis|cellular defense response|cytokine-mediated signaling pathway|defense response to virus|inflammatory response|innate immune response|interspecies interaction between organisms|membrane protein intracellular domain proteolysis|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of transcription, DNA-dependent|nerve growth factor receptor signaling pathway|nucleotide-binding oligomerization domain containing 2 signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of inflammatory response|response to interleukin-1|response to UV-B|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|transcription factor complex	activating transcription factor binding|chromatin binding|identical protein binding|NF-kappaB binding|phosphate binding|protein kinase binding|protein N-terminus binding|repressing transcription factor binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|ubiquitin protein ligase binding			lung(3)|ovary(1)	4						TTCATCTCCTGAAAGGAGGCC	0.632		NaN											0	0	0	0.014323	0	23	56									
SF3B2	10992	broad.mit.edu	37	11	65824745	65824745	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr11:65824745C>G	uc001ogy.1	+	7	716	c.676C>G	c.(676-678)CCA>GCA	p.P226A		NM_006842	NP_006833	Q13435	SF3B2_HUMAN	splicing factor 3B subunit 2	226					interspecies interaction between organisms	catalytic step 2 spliceosome|nucleoplasm|U12-type spliceosomal complex	nucleic acid binding|protein binding			ovary(2)|breast(1)	3						AGTAGCTGCTCCAGTGGGCCC	0.542		NaN											0	0	0	0.011902	0	37	214									
RBM4	5936	broad.mit.edu	37	11	66410998	66410998	+	Silent	SNP	C	C	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr11:66410998C>A	uc009yrj.2	+	3	978	c.490C>A	c.(490-492)CGG>AGG	p.R164R	RBM4_uc009yrk.2_Silent_p.R139R|RBM4_uc001oiw.1_Silent_p.R164R|RBM4_uc001oix.1_Intron|RBM4_uc010rpj.1_Intron|RBM4_uc001oiy.1_Silent_p.R164R|RBM4_uc001oiz.1_Silent_p.R164R	NM_002896	NP_002887	Q9BWF3	RBM4_HUMAN	RNA binding motif protein 4	164	CCHC-type.				circadian regulation of gene expression|entrainment of circadian clock by photoperiod|mRNA processing|negative regulation of translation in response to stress|negative regulation of translation involved in gene silencing by miRNA|negative regulation of translational initiation|positive regulation of muscle cell differentiation|regulation of alternative nuclear mRNA splicing, via spliceosome|regulation of nucleocytoplasmic transport|RNA splicing|stress-activated MAPK cascade	nuclear speck|nucleolus|stress granule	miRNA binding|mRNA 3'-UTR binding|nucleotide binding|protein binding|zinc ion binding			ovary(1)	1				Lung(977;0.0112)|LUSC - Lung squamous cell carcinoma(976;0.0266)		CGGCTGCTATCGGTGCGGGAA	0.567		NaN											1	0	0.000274275	0.004482	0.000279026	7	53									
RBM4B	83759	broad.mit.edu	37	11	66444285	66444285	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr11:66444285C>T	uc001oja.2	-	1	935	c.266G>A	c.(265-267)TGT>TAT	p.C89Y	RBM4B_uc001ojb.2_Missense_Mutation_p.C89Y	NM_031492	NP_113680	Q9BQ04	RBM4B_HUMAN	RNA binding motif protein 4B	89	RRM 2.				circadian regulation of gene expression|entrainment of circadian clock by photoperiod|mRNA processing|RNA splicing	nucleolus	nucleotide binding|RNA binding|zinc ion binding				0						TTGGTTGGTACAAGTGGGGCT	0.488		NaN											0	0	0	0.01441	0	124	295									
TPCN2	219931	broad.mit.edu	37	11	68838874	68838874	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr11:68838874C>T	uc001oos.2	+	10	1062	c.946C>T	c.(946-948)CGG>TGG	p.R316W	TPCN2_uc009ysk.1_RNA|TPCN2_uc001oor.2_Missense_Mutation_p.R231W|TPCN2_uc010rqg.1_Missense_Mutation_p.R316W|TPCN2_uc001oot.2_5'Flank	NM_139075	NP_620714	Q8NHX9	TPC2_HUMAN	two pore segment channel 2	316	Cytoplasmic (Potential).				cellular calcium ion homeostasis|smooth muscle contraction	endosome membrane|integral to membrane|lysosomal membrane	NAADP-sensitive calcium-release channel activity|voltage-gated calcium channel activity				0			STAD - Stomach adenocarcinoma(18;0.0208)|LUAD - Lung adenocarcinoma(13;0.0713)			CAGTCAGTTCCGGGGCTACCT	0.602		NaN											0	0	0	0.000602	0	5	12									
PIWIL4	143689	broad.mit.edu	37	11	94340677	94340677	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr11:94340677C>T	uc001pfa.2	+	14	1922	c.1711C>T	c.(1711-1713)CCA>TCA	p.P571S	PIWIL4_uc010rue.1_RNA|PIWIL4_uc009ywk.1_RNA	NM_152431	NP_689644	Q7Z3Z4	PIWL4_HUMAN	piwi-like 4	571	Piwi.				cell differentiation|DNA methylation involved in gamete generation|gene silencing by RNA|meiosis|multicellular organismal development|piRNA metabolic process|regulation of translation|spermatogenesis	nucleus|piP-body	piRNA binding			skin(1)	1		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.0123)				CTCAGACTGCCCAGTCCCAAG	0.423		NaN											0	0	0	0.005443	0	26	48									
RDX	5962	broad.mit.edu	37	11	110124732	110124732	+	Missense_Mutation	SNP	T	T	C			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr11:110124732T>C	uc001pku.2	-	9	1208	c.898A>G	c.(898-900)ATT>GTT	p.I300V	RDX_uc009yxx.1_RNA|RDX_uc009yxy.2_Missense_Mutation_p.I300V|RDX_uc009yxz.2_Intron|RDX_uc009yya.2_Intron|RDX_uc010rwe.1_Missense_Mutation_p.I164V	NM_002906	NP_002897	P35241	RADI_HUMAN	radixin	300					actin filament capping	cleavage furrow|cytoskeleton|extrinsic to membrane|Golgi apparatus|nucleolus|plasma membrane	actin binding				0		all_cancers(61;7.18e-13)|all_epithelial(67;2.61e-07)|Melanoma(852;1.46e-05)|all_hematologic(158;3.66e-05)|Acute lymphoblastic leukemia(157;3.95e-05)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)|Breast(348;0.0544)		Epithelial(105;1.13e-06)|BRCA - Breast invasive adenocarcinoma(274;9.75e-06)|all cancers(92;5.9e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.0248)		TGTACTTCAATAGTATCAGGC	0.408		NaN											0	0	0	0.008361	0	32	95									
BUD13	84811	broad.mit.edu	37	11	116640940	116640940	+	Splice_Site	SNP	T	T	C			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr11:116640940T>C	uc001ppn.2	-	2	178	c.144_splice	c.e2-1	p.G48_splice	BUD13_uc001ppo.2_Splice_Site_p.G48_splice|BUD13_uc009yzc.2_Splice_Site_p.G48_splice	NM_032725	NP_116114	Q9BRD0	BUD13_HUMAN	BUD13 homolog isoform 1											large_intestine(1)|pancreas(1)	2	all_hematologic(175;0.0487)	all_cancers(61;1.72e-06)|all_epithelial(67;0.000735)|Melanoma(852;0.022)|Acute lymphoblastic leukemia(157;0.0255)|Medulloblastoma(222;0.0523)|Breast(348;0.056)|all_hematologic(158;0.0588)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|Epithelial(105;5.81e-06)|all cancers(92;0.000144)|OV - Ovarian serous cystadenocarcinoma(223;0.154)		ATCCGCATTCTAAATGAGAAT	0.368		NaN											0	0	0	0.00245	0	13	57									
MLL	4297	broad.mit.edu	37	11	118344511	118344511	+	Silent	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr11:118344511G>A	uc001pta.2	+	3	2660	c.2637G>A	c.(2635-2637)GAG>GAA	p.E879E	MLL_uc001ptb.2_Silent_p.E879E|MLL_uc001psz.1_Silent_p.E912E|MLL_uc001ptd.1_Intron	NM_005933	NP_005924	Q03164	MLL1_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	879					apoptosis|embryonic hemopoiesis|histone H4-K16 acetylation|positive regulation of transcription, DNA-dependent|protein complex assembly|transcription from RNA polymerase II promoter	MLL1 complex	AT DNA binding|histone acetyl-lysine binding|histone methyltransferase activity (H3-K4 specific)|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|unmethylated CpG binding|zinc ion binding			lung(7)|ovary(5)|kidney(5)|central_nervous_system(3)|pancreas(2)|urinary_tract(1)|breast(1)|skin(1)	25	all_hematologic(175;0.046)	all_hematologic(192;1.13e-50)|all_neural(223;3.18e-06)|Breast(348;1.07e-05)|Medulloblastoma(222;0.0425)|Hepatocellular(160;0.244)		OV - Ovarian serous cystadenocarcinoma(223;2.77e-44)|BRCA - Breast invasive adenocarcinoma(274;1.2e-11)|Lung(307;3.48e-06)|LUSC - Lung squamous cell carcinoma(976;7.92e-05)|Colorectal(284;0.144)		gagaccgggagagagaaaagg	0.274		NaN	T|O	MLL|MLLT1|MLLT2|MLLT3|MLLT4|MLLT7|MLLT10|MLLT6|ELL|EPS15|AF1Q|CREBBP|SH3GL1|FNBP1|PNUTL1|MSF|GPHN|GMPS|SSH3BP1|ARHGEF12|GAS7|FOXO3A|LAF4|LCX|SEPT6|LPP|CBFA2T1|GRAF|EP300|PICALM|HEAB	AML|ALL								0	0	0	0.00278	0	23	54									
TRIM29	23650	broad.mit.edu	37	11	120008356	120008356	+	Silent	SNP	G	G	C			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr11:120008356G>C	uc001pwz.2	-	1	508	c.384C>G	c.(382-384)CGC>CGG	p.R128R	TRIM29_uc001pxa.2_RNA	NM_012101	NP_036233	Q14134	TRI29_HUMAN	tripartite motif protein TRIM29	128					transcription from RNA polymerase II promoter	cytoplasm	protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|breast(1)|kidney(1)|skin(1)	4		Breast(109;0.00117)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;5.37e-06)		AAATGGACTTGCGCAGCTCGC	0.637		NaN											0	0	0	0.00874	0	40	215									
GRIK4	2900	broad.mit.edu	37	11	120673512	120673512	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr11:120673512G>C	uc001pxn.2	+	4	480	c.193G>C	c.(193-195)GAA>CAA	p.E65Q	GRIK4_uc009zav.1_Missense_Mutation_p.E65Q|GRIK4_uc009zaw.1_Missense_Mutation_p.E65Q|GRIK4_uc009zax.1_Missense_Mutation_p.E65Q	NM_014619	NP_055434	Q16099	GRIK4_HUMAN	glutamate receptor KA1 precursor	65	Extracellular (Potential).				glutamate signaling pathway|synaptic transmission	cell junction|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			ovary(2)|central_nervous_system(1)	3		Breast(109;0.000868)|Medulloblastoma(222;0.0453)|all_neural(223;0.116)|all_hematologic(192;0.21)		BRCA - Breast invasive adenocarcinoma(274;1.24e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.116)	L-Glutamic Acid(DB00142)	GGCCAAGGTCGAAGTGGACAT	0.602		NaN									OREG0021427	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.013537	0	12	67									
ROBO4	54538	broad.mit.edu	37	11	124757737	124757737	+	Splice_Site	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr11:124757737C>T	uc001qbg.2	-	13	2089	c.1949_splice	c.e13-1	p.E650_splice	ROBO4_uc010sas.1_Splice_Site_p.E505_splice|ROBO4_uc001qbh.2_Splice_Site_p.E540_splice|ROBO4_uc001qbi.2_Splice_Site_p.E208_splice|ROBO4_uc010sat.1_Intron	NM_019055	NP_061928	Q8WZ75	ROBO4_HUMAN	roundabout homolog 4, magic roundabout						angiogenesis|cell differentiation	integral to membrane	receptor activity			ovary(1)|skin(1)	2	all_hematologic(175;0.215)	Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|Breast(109;0.171)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.5e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0301)		TGCTGCAGCTCTGCAAAGAAA	0.562		NaN											0	0	0	0.001855	0	14	45									
SLC37A2	219855	broad.mit.edu	37	11	124949113	124949113	+	Silent	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr11:124949113C>T	uc001qbn.2	+	5	671	c.420C>T	c.(418-420)ATC>ATT	p.I140I	SLC37A2_uc010sau.1_Silent_p.I140I	NM_001145290	NP_001138762	Q8TED4	SPX2_HUMAN	solute carrier family 37 (glycerol-3-phosphate	140					carbohydrate transport|transmembrane transport	integral to membrane				ovary(2)	2	all_hematologic(175;0.215)	Breast(109;0.012)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.152)|all_lung(97;0.159)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.61e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0384)		TCTGGAACATCCACGAGCTCT	0.557		NaN											0	0	0	0.007291	0	29	133									
ARHGAP32	9743	broad.mit.edu	37	11	128910840	128910840	+	Missense_Mutation	SNP	T	T	C			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr11:128910840T>C	uc009zcp.2	-	10	986	c.986A>G	c.(985-987)AAC>AGC	p.N329S	ARHGAP32_uc009zcq.1_Missense_Mutation_p.N289S|ARHGAP32_uc001qfb.2_Missense_Mutation_p.N114S	NM_001142685	NP_001136157	A7KAX9	RHG32_HUMAN	Rho GTPase-activating protein isoform 1	329					cell communication|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cell cortex|cell junction|cytosol|dendritic spine|endoplasmic reticulum membrane|endosome membrane|Golgi membrane|postsynaptic density|postsynaptic membrane	GTPase activator activity|phosphatidylinositol binding			lung(3)|ovary(2)	5						TGGCACTGAGTTGGTCACTGA	0.398		NaN											0	0	0	0.000602	0	5	17									
BARX2	8538	broad.mit.edu	37	11	129246012	129246012	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr11:129246012G>A	uc001qfc.3	+	1	132	c.82G>A	c.(82-84)GAC>AAC	p.D28N		NM_003658	NP_003649	Q9UMQ3	BARX2_HUMAN	BarH-like homeobox 2	28											0	all_hematologic(175;0.0749)	Lung NSC(97;0.000383)|all_lung(97;0.000824)|Breast(109;0.000962)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.00929)|Lung(977;0.0245)|LUSC - Lung squamous cell carcinoma(976;0.0253)		TTTCATGATCGACGAGATCCT	0.617		NaN									OREG0021508	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.01441	0	62	131									
BARX2	8538	broad.mit.edu	37	11	129246023	129246023	+	Silent	SNP	C	C	G			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr11:129246023C>G	uc001qfc.3	+	1	143	c.93C>G	c.(91-93)CTC>CTG	p.L31L		NM_003658	NP_003649	Q9UMQ3	BARX2_HUMAN	BarH-like homeobox 2	31											0	all_hematologic(175;0.0749)	Lung NSC(97;0.000383)|all_lung(97;0.000824)|Breast(109;0.000962)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.00929)|Lung(977;0.0245)|LUSC - Lung squamous cell carcinoma(976;0.0253)		ACGAGATCCTCTCCAAGGAGA	0.597		NaN									OREG0021508	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.010818	0	33	178									
SNX19	399979	broad.mit.edu	37	11	130785628	130785628	+	Silent	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr11:130785628G>A	uc001qgk.3	-	1	755	c.207C>T	c.(205-207)CTC>CTT	p.L69L	SNX19_uc010sce.1_Intron|SNX19_uc010scf.1_Intron|SNX19_uc010scg.1_Intron|SNX19_uc001qgl.3_Silent_p.L69L|SNX19_uc009zcx.1_Intron	NM_014758	NP_055573	Q92543	SNX19_HUMAN	sorting nexin 19	69					cell communication|protein transport	cytoplasmic vesicle membrane	phosphatidylinositol binding|protein binding			ovary(2)|lung(2)	4	all_hematologic(175;0.0597)	Lung NSC(97;0.000272)|all_lung(97;0.000608)|Breast(109;0.000962)|all_neural(223;0.0298)|Medulloblastoma(222;0.0425)		OV - Ovarian serous cystadenocarcinoma(99;0.0195)|Lung(977;0.233)		CCACTCCAGCGAGGCTGGAGC	0.602		NaN											0	0	0	0.013537	0	8	37									
CCDC77	84318	broad.mit.edu	37	12	538021	538021	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr12:538021C>T	uc001qig.2	+	6	680	c.500C>T	c.(499-501)CCT>CTT	p.P167L	CCDC77_uc009zdk.2_Missense_Mutation_p.P135L|CCDC77_uc010sdp.1_Missense_Mutation_p.P135L|CCDC77_uc010sdq.1_Missense_Mutation_p.P135L	NM_032358	NP_115734	Q9BR77	CCD77_HUMAN	coiled-coil domain containing 77 isoform a	167						centrosome				ovary(1)	1	all_cancers(10;0.0149)|all_epithelial(11;0.035)|all_lung(10;0.111)|Ovarian(42;0.142)|Lung NSC(10;0.156)		OV - Ovarian serous cystadenocarcinoma(31;0.00123)|BRCA - Breast invasive adenocarcinoma(9;0.033)			TGTAAGGAGCCTCCTCACAAA	0.443		NaN											0	0	0	0.01441	0	70	167									
NCAPD2	9918	broad.mit.edu	37	12	6626188	6626188	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr12:6626188G>C	uc001qoo.2	+	10	1228	c.1182G>C	c.(1180-1182)CAG>CAC	p.Q394H	NCAPD2_uc009zen.1_Missense_Mutation_p.Q266H|NCAPD2_uc010sfd.1_Missense_Mutation_p.Q349H	NM_014865	NP_055680	Q15021	CND1_HUMAN	non-SMC condensin I complex, subunit D2	394	Interactions with SMC2 and SMC4.				cell division|mitotic chromosome condensation	condensin core heterodimer|cytoplasm	histone binding			ovary(2)|lung(1)|breast(1)|kidney(1)	5						TTGTCCAGCAGAAGGTAACCA	0.458		NaN											0	0	0	0.009535	0	31	154									
NCAPD2	9918	broad.mit.edu	37	12	6626830	6626830	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr12:6626830G>C	uc001qoo.2	+	12	1435	c.1389G>C	c.(1387-1389)CAG>CAC	p.Q463H	NCAPD2_uc009zen.1_Missense_Mutation_p.Q335H|NCAPD2_uc010sfd.1_Missense_Mutation_p.Q418H	NM_014865	NP_055680	Q15021	CND1_HUMAN	non-SMC condensin I complex, subunit D2	463	Interactions with SMC2 and SMC4.				cell division|mitotic chromosome condensation	condensin core heterodimer|cytoplasm	histone binding			ovary(2)|lung(1)|breast(1)|kidney(1)	5						TGAGGGCCCAGAGGCGAACTG	0.483		NaN											0	0	0	0.000602	0	5	51									
ZNF384	171017	broad.mit.edu	37	12	6777233	6777233	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr12:6777233G>T	uc010sfh.1	-	11	1589	c.1381C>A	c.(1381-1383)CAG>AAG	p.Q461K	ZNF384_uc001qpz.2_Missense_Mutation_p.Q400K|ZNF384_uc001qqa.2_Missense_Mutation_p.Q400K|ZNF384_uc001qqb.2_Missense_Mutation_p.Q384K|ZNF384_uc001qqc.2_Missense_Mutation_p.Q400K|ZNF384_uc001qqd.2_Missense_Mutation_p.Q345K|ZNF384_uc001qqe.2_Missense_Mutation_p.Q384K	NM_001135734	NP_001129206	Q8TF68	ZN384_HUMAN	nuclear matrix transcription factor 4 isoform d	461	Gln-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding		EWSR1/ZNF384(4)	haematopoietic_and_lymphoid_tissue(4)|central_nervous_system(3)|kidney(1)	8						acctgttgctgAAGATCAGGC	0.204		NaN	T	EWSR1|TAF15 	ALL								1	0	9.31168e-06	0.001855	9.5059e-06	10	49									
CD163L1	283316	broad.mit.edu	37	12	7559389	7559389	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr12:7559389C>G	uc001qsy.2	-	5	852	c.826G>C	c.(826-828)GAG>CAG	p.E276Q	CD163L1_uc010sge.1_Missense_Mutation_p.E286Q	NM_174941	NP_777601	Q9NR16	C163B_HUMAN	scavenger receptor cysteine-rich type 1	276	SRCR 3.|Extracellular (Potential).					extracellular region|integral to membrane|plasma membrane	scavenger receptor activity			ovary(8)|skin(2)|central_nervous_system(1)	11						ATTTTCAGCTCTACTCTCCCC	0.473		NaN											0	0	0	0.012319	0	19	110									
CLEC9A	283420	broad.mit.edu	37	12	10218209	10218209	+	Missense_Mutation	SNP	A	A	C			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr12:10218209A>C	uc001qxa.2	+	9	1317	c.704A>C	c.(703-705)TAT>TCT	p.Y235S		NM_207345	NP_997228	Q6UXN8	CLC9A_HUMAN	C-type lectin domain family 9, member A	235	Extracellular (Potential).				positive regulation of cytokine secretion|receptor-mediated endocytosis	cell surface|integral to membrane	receptor activity|sugar binding			ovary(1)	1						TGTGAGAAGTATGCGTTGAGA	0.448		NaN											0	0	0	0.013726	0	31	145									
DUSP16	80824	broad.mit.edu	37	12	12630725	12630725	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr12:12630725G>A	uc001rao.1	-	7	1672	c.1040C>T	c.(1039-1041)TCA>TTA	p.S347L	DUSP16_uc001ram.1_5'Flank|DUSP16_uc001ran.1_Missense_Mutation_p.S199L	NM_030640	NP_085143	Q9BY84	DUS16_HUMAN	dual specificity phosphatase 16	347					inactivation of MAPK activity|MAPK export from nucleus|MAPK phosphatase export from nucleus, leptomycin B sensitive	cytoplasmic membrane-bounded vesicle|nucleus	MAP kinase tyrosine/serine/threonine phosphatase activity|protein tyrosine phosphatase activity				0		Prostate(47;0.0687)		BRCA - Breast invasive adenocarcinoma(232;0.0203)		TGCTGCCTCTGAGGTAGCAGA	0.537		NaN											0	0	0	0.008361	0	27	46									
DUSP16	80824	broad.mit.edu	37	12	12630832	12630832	+	Silent	SNP	G	G	C			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr12:12630832G>C	uc001rao.1	-	7	1565	c.933C>G	c.(931-933)CTC>CTG	p.L311L	DUSP16_uc001ram.1_5'Flank|DUSP16_uc001ran.1_Silent_p.L163L	NM_030640	NP_085143	Q9BY84	DUS16_HUMAN	dual specificity phosphatase 16	311					inactivation of MAPK activity|MAPK export from nucleus|MAPK phosphatase export from nucleus, leptomycin B sensitive	cytoplasmic membrane-bounded vesicle|nucleus	MAP kinase tyrosine/serine/threonine phosphatase activity|protein tyrosine phosphatase activity				0		Prostate(47;0.0687)		BRCA - Breast invasive adenocarcinoma(232;0.0203)		GCAGCAGCTTGAGTTTGCTCT	0.517		NaN											0	0	0	0.01441	0	49	92									
DUSP16	80824	broad.mit.edu	37	12	12630910	12630910	+	Silent	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr12:12630910G>A	uc001rao.1	-	7	1487	c.855C>T	c.(853-855)TTC>TTT	p.F285F	DUSP16_uc001ram.1_5'Flank|DUSP16_uc001ran.1_Silent_p.F137F	NM_030640	NP_085143	Q9BY84	DUS16_HUMAN	dual specificity phosphatase 16	285	Tyrosine-protein phosphatase.				inactivation of MAPK activity|MAPK export from nucleus|MAPK phosphatase export from nucleus, leptomycin B sensitive	cytoplasmic membrane-bounded vesicle|nucleus	MAP kinase tyrosine/serine/threonine phosphatase activity|protein tyrosine phosphatase activity				0		Prostate(47;0.0687)		BRCA - Breast invasive adenocarcinoma(232;0.0203)		CCAGAAAATTGAAGTTTGGAG	0.398		NaN											0	0	0	0.01441	0	60	152									
ETNK1	55500	broad.mit.edu	37	12	22778128	22778128	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr12:22778128G>A	uc001rft.2	+	1	53	c.31G>A	c.(31-33)GAC>AAC	p.D11N	ETNK1_uc009ziz.2_Missense_Mutation_p.D11N|ETNK1_uc001rfs.2_Missense_Mutation_p.D11N	NM_018638	NP_061108	Q9HBU6	EKI1_HUMAN	ethanolamine kinase 1 isoform A	11					phosphatidylethanolamine biosynthetic process	cytoplasm	ATP binding|ethanolamine kinase activity				0						GTCCAGCTCCGACAACAGGAA	0.716		NaN											0	0	0	0.009096	0	3	5									
C12orf11	55726	broad.mit.edu	37	12	27067466	27067466	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr12:27067466C>G	uc001rhk.3	-	12	1831	c.1294G>C	c.(1294-1296)GAC>CAC	p.D432H	C12orf11_uc001rhj.3_Intron|C12orf11_uc010sjk.1_Missense_Mutation_p.D331H	NM_018164	NP_060634	Q9NVM9	M89BB_HUMAN	hypothetical protein LOC55726	432					cell division|mitosis|regulation of mitotic cell cycle		protein binding			large_intestine(1)|ovary(1)|central_nervous_system(1)	3	Colorectal(261;0.0847)					TATCTGGGGTCTAGAAAAGGA	0.348		NaN											0	0	0	0.00499	0	17	63									
KLHDC5	57542	broad.mit.edu	37	12	27933977	27933977	+	Silent	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr12:27933977C>T	uc001rij.2	+	1	791	c.714C>T	c.(712-714)CCC>CCT	p.P238P	KLHDC5_uc009zjj.2_RNA	NM_020782	NP_065833	Q9P2K6	KLDC5_HUMAN	kelch domain containing 5	238	Kelch 2.									ovary(1)|central_nervous_system(1)	2	Lung SC(9;0.0873)					ACCTTCCTCCCGACCTGGTCA	0.622		NaN											0	0	0	0.001984	0	7	15									
TMTC1	83857	broad.mit.edu	37	12	29757224	29757224	+	Silent	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr12:29757224C>T	uc001rjb.2	-	7	1287	c.813G>A	c.(811-813)GAG>GAA	p.E271E	TMTC1_uc001riz.2_Silent_p.E28E|TMTC1_uc001rja.2_Silent_p.E115E|TMTC1_uc001rjc.1_Silent_p.E333E	NM_175861	NP_787057	Q8IUR5	TMTC1_HUMAN	transmembrane and tetratricopeptide repeat	379						integral to membrane	binding				0	Lung NSC(12;7.61e-10)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.032)					CCTCCTTGTGCTCCAGTCTCT	0.468		NaN											0	0	0	0.004482	0	9	30									
DENND5B	160518	broad.mit.edu	37	12	31613259	31613259	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr12:31613259G>A	uc001rki.1	-	4	1147	c.961C>T	c.(961-963)CAA>TAA	p.Q321*	DENND5B_uc001rkh.1_Nonsense_Mutation_p.Q356*|DENND5B_uc009zjq.1_Nonsense_Mutation_p.Q240*|DENND5B_uc001rkj.2_Nonsense_Mutation_p.Q343*|DENND5B_uc001rkk.1_Nonsense_Mutation_p.Q243*	NM_144973	NP_659410	Q6ZUT9	DEN5B_HUMAN	DENN/MADD domain containing 5B	321	DENN.					integral to membrane				ovary(1)|central_nervous_system(1)	2						TGTTGCCATTGAAATGGGAAC	0.438		NaN											0	0	0	0.014323	0	23	33									
PDZRN4	29951	broad.mit.edu	37	12	41967407	41967407	+	Silent	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr12:41967407C>T	uc010skn.1	+	10	2297	c.2229C>T	c.(2227-2229)AGC>AGT	p.S743S	PDZRN4_uc001rmq.3_Silent_p.S684S|PDZRN4_uc009zjz.2_Silent_p.S682S|PDZRN4_uc001rmr.2_Silent_p.S569S	NM_013377	NP_037509	Q6ZMN7	PZRN4_HUMAN	PDZ domain containing RING finger 4 isoform 2	942							ubiquitin-protein ligase activity|zinc ion binding			lung(3)|skin(3)|ovary(2)|large_intestine(1)|kidney(1)|pancreas(1)	11	all_cancers(12;0.000673)	Lung NSC(34;0.0205)|all_lung(34;0.0264)				GCTACTGGAGCAAAGAGGAGA	0.542		NaN											0	0	0	0.00499	0	17	41									
PRICKLE1	144165	broad.mit.edu	37	12	42854114	42854114	+	Nonsense_Mutation	SNP	C	C	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr12:42854114C>A	uc010skv.1	-	8	2280	c.1993G>T	c.(1993-1995)GAG>TAG	p.E665*	PRICKLE1_uc001rnl.2_Nonsense_Mutation_p.E665*|PRICKLE1_uc010skw.1_Nonsense_Mutation_p.E665*|PRICKLE1_uc001rnm.2_Nonsense_Mutation_p.E665*|PRICKLE1_uc001rnk.1_5'Flank	NM_001144881	NP_001138353	Q96MT3	PRIC1_HUMAN	prickle homolog 1	665	Arg/His-rich.				negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cardiac muscle cell myoblast differentiation|negative regulation of transcription, DNA-dependent|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein ubiquitination|protein import into nucleus	cytosol|nuclear membrane	zinc ion binding			ovary(3)|skin(1)	4	all_cancers(12;4.25e-05)|Breast(8;0.176)			GBM - Glioblastoma multiforme(48;0.2)		GATCCCCTCTCTTCAAAATTG	0.483		NaN											1	0	0.000566183	0.00499	0.000575326	17	79									
ANO6	196527	broad.mit.edu	37	12	45782045	45782045	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr12:45782045G>A	uc001roo.2	+	11	1602	c.1267G>A	c.(1267-1269)GAA>AAA	p.E423K	ANO6_uc010sld.1_Missense_Mutation_p.E423K|ANO6_uc010sle.1_Missense_Mutation_p.E423K|ANO6_uc010slf.1_Missense_Mutation_p.E444K|ANO6_uc010slg.1_Missense_Mutation_p.E405K	NM_001025356	NP_001020527	Q4KMQ2	ANO6_HUMAN	anoctamin 6 isoform a	423	Cytoplasmic (Potential).				activation of blood coagulation via clotting cascade|phosphatidylserine exposure on blood platelet	chloride channel complex|plasma membrane	chloride channel activity			ovary(1)|kidney(1)	2						ACCAGAATACGAAGCACGATG	0.403		NaN											0	0	0	0.01441	0	55	128									
TROAP	10024	broad.mit.edu	37	12	49721057	49721057	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr12:49721057C>G	uc001rtx.3	+	8	1002	c.835C>G	c.(835-837)CTT>GTT	p.L279V	TROAP_uc009zlh.2_Missense_Mutation_p.L279V|TROAP_uc001rty.2_5'UTR	NM_005480	NP_005471	Q12815	TROAP_HUMAN	tastin isoform 1	279					cell adhesion	cytoplasm				ovary(1)	1						TGTGGCCTCTCTTGGTCTGGC	0.512		NaN											0	0	0	0.00278	0	21	146									
SPATS2	65244	broad.mit.edu	37	12	49890687	49890687	+	Nonsense_Mutation	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr12:49890687C>T	uc001rud.2	+	8	1587	c.598C>T	c.(598-600)CAA>TAA	p.Q200*	SPATS2_uc001rue.2_RNA|SPATS2_uc009zli.1_Nonsense_Mutation_p.Q200*|SPATS2_uc001ruf.2_Nonsense_Mutation_p.Q200*|SPATS2_uc001rug.2_Nonsense_Mutation_p.Q200*	NM_023071	NP_075559	Q86XZ4	SPAS2_HUMAN	spermatogenesis associated, serine-rich 2	200						cytoplasm				breast(1)	1						TCACAATTCTCAACAACCCAG	0.433		NaN											0	0	0	0.01441	0	62	126									
SPATS2	65244	broad.mit.edu	37	12	49918549	49918549	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr12:49918549C>T	uc001rud.2	+	13	2185	c.1196C>T	c.(1195-1197)TCT>TTT	p.S399F	SPATS2_uc001rue.2_RNA|SPATS2_uc009zli.1_Missense_Mutation_p.S399F|SPATS2_uc001ruf.2_Missense_Mutation_p.S399F|SPATS2_uc001rug.2_Missense_Mutation_p.S399F	NM_023071	NP_075559	Q86XZ4	SPAS2_HUMAN	spermatogenesis associated, serine-rich 2	399	Ser-rich.					cytoplasm				breast(1)	1						AGTGATGCCTCTGCTGCTTCC	0.493		NaN											0	0	0	0.01441	0	63	136									
TMPRSS12	283471	broad.mit.edu	37	12	51279160	51279160	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr12:51279160G>A	uc001rwx.3	+	4	831	c.784G>A	c.(784-786)GAT>AAT	p.D262N	TMPRSS12_uc001rwy.2_Missense_Mutation_p.D262N	NM_182559	NP_872365	Q86WS5	TMPSC_HUMAN	transmembrane protease, serine 12 precursor	262	Peptidase S1.|Extracellular (Potential).				proteolysis	integral to membrane	serine-type endopeptidase activity				0						TGGAGCTTTTGATACTTGCAG	0.378		NaN											0	0	0	0.01441	0	92	223									
DAZAP2	9802	broad.mit.edu	37	12	51634204	51634204	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr12:51634204C>G	uc010snd.1	+	2	275	c.91C>G	c.(91-93)CAG>GAG	p.Q31E	DAZAP2_uc001ryb.2_Missense_Mutation_p.Q31E|DAZAP2_uc010snc.1_Missense_Mutation_p.Q31E|DAZAP2_uc010sne.1_Missense_Mutation_p.Q31E|DAZAP2_uc010snf.1_Missense_Mutation_p.Q31E	NM_001136266	NP_001129738	Q15038	DAZP2_HUMAN	DAZ associated protein 2 isoform c	31	Pro-rich.						WW domain binding				0						GCATCTTCCTCAGGCTCCACC	0.488		NaN											0	0	0	0.010504	0	21	115									
MFSD5	84975	broad.mit.edu	37	12	53647277	53647277	+	Nonsense_Mutation	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr12:53647277C>T	uc001sci.1	+	2	849	c.658C>T	c.(658-660)CGA>TGA	p.R220*	MFSD5_uc001sch.1_Nonsense_Mutation_p.R327*	NM_032889	NP_116278	Q6N075	MFSD5_HUMAN	major facilitator superfamily domain containing	220					transport	integral to membrane				skin(2)|ovary(1)	3						CTTGGCCCTTCGAAACTGGGG	0.662		NaN											0	0	0	0.003271	0	32	79									
ESPL1	9700	broad.mit.edu	37	12	53677897	53677897	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr12:53677897G>A	uc001sck.2	+	17	3224	c.3133G>A	c.(3133-3135)GAT>AAT	p.D1045N	ESPL1_uc001scj.2_Missense_Mutation_p.D720N|ESPL1_uc010soe.1_Missense_Mutation_p.D256N	NM_012291	NP_036423	Q14674	ESPL1_HUMAN	separase	1045					apoptosis|cytokinesis|establishment of mitotic spindle localization|mitotic sister chromatid segregation|negative regulation of sister chromatid cohesion|positive regulation of mitotic metaphase/anaphase transition|proteolysis	centrosome|nucleus	cysteine-type peptidase activity|protein binding			lung(1)|kidney(1)|skin(1)	3						CAATGACATTGATCTCTGTCA	0.542		NaN											0	0	0	0.01441	0	77	222									
HOXC6	3223	broad.mit.edu	37	12	54423560	54423560	+	Silent	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr12:54423560C>T	uc001sev.2	+	2	634	c.522C>T	c.(520-522)ATC>ATT	p.I174I	HOXC6_uc001ses.2_Silent_p.I92I|HOXC5_uc001set.2_Intron|HOXC4_uc001seu.2_Intron	NM_004503	NP_004494	P09630	HXC6_HUMAN	homeobox C6 isoform 1	174	Homeobox.				regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			ovary(2)|upper_aerodigestive_tract(1)	3						GCATCGAGATCGCCAACGCGC	0.562		NaN											0	0	0	0.00333	0	24	92									
DGKA	1606	broad.mit.edu	37	12	56334172	56334172	+	Silent	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr12:56334172C>T	uc001sij.2	+	11	1137	c.873C>T	c.(871-873)ATC>ATT	p.I291I	DGKA_uc009zoc.1_Silent_p.I291I|DGKA_uc001sih.1_Silent_p.I179I|DGKA_uc001sii.1_Silent_p.I149I|DGKA_uc009zod.1_Silent_p.I210I|DGKA_uc009zoe.1_3'UTR|DGKA_uc001sik.2_Silent_p.I291I|DGKA_uc001sil.2_Silent_p.I291I|DGKA_uc001sim.2_Silent_p.I291I|DGKA_uc001sin.2_Silent_p.I291I|DGKA_uc009zof.2_5'UTR|DGKA_uc001sio.2_Silent_p.I33I	NM_001345	NP_001336	P23743	DGKA_HUMAN	diacylglycerol kinase, alpha 80kDa	291	Phorbol-ester/DAG-type 2.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	plasma membrane	ATP binding|calcium ion binding|diacylglycerol kinase activity			ovary(3)|pancreas(1)	4					Vitamin E(DB00163)	AGATCCGGATCTACCACAGTC	0.582		NaN									OREG0021913	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.005524	0	38	84									
ESYT1	23344	broad.mit.edu	37	12	56536448	56536448	+	Silent	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr12:56536448C>T	uc001sjq.2	+	26	2870	c.2820C>T	c.(2818-2820)CTC>CTT	p.L940L	ESYT1_uc001sjr.2_Silent_p.L950L	NM_015292	NP_056107	Q9BSJ8	ESYT1_HUMAN	extended synaptotagmin-like protein 1	940						integral to membrane				ovary(4)|skin(1)	5						AACCAGAGCTCTCGGGGGGAC	0.602		NaN											0	0	0	0.008291	0	11	60									
TIMELESS	8914	broad.mit.edu	37	12	56816695	56816695	+	Missense_Mutation	SNP	A	A	C			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr12:56816695A>C	uc001slf.2	-	19	2542	c.2374T>G	c.(2374-2376)TTG>GTG	p.L792V		NM_003920	NP_003911	Q9UNS1	TIM_HUMAN	timeless homolog	792					cell division|circadian rhythm|detection of abiotic stimulus|mitosis|morphogenesis of an epithelium|negative regulation of transcription, DNA-dependent|regulation of S phase|response to DNA damage stimulus|transcription, DNA-dependent	nuclear chromatin				ovary(5)|breast(2)|pancreas(1)	8						TTCCAGAACAACAGCTCCACA	0.502		NaN											0	0	0	0.011902	0	47	102									
MYO1A	4640	broad.mit.edu	37	12	57436895	57436895	+	Silent	SNP	G	G	C			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr12:57436895G>C	uc001smw.3	-	12	1302	c.1059C>G	c.(1057-1059)CTC>CTG	p.L353L	MYO1A_uc010sqz.1_Silent_p.L191L|MYO1A_uc009zpd.2_Silent_p.L353L	NM_005379	NP_005370	Q9UBC5	MYO1A_HUMAN	myosin IA	353	Myosin head-like.				sensory perception of sound|vesicle localization	brush border|cortical actin cytoskeleton|filamentous actin|lateral plasma membrane|microvillus|myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			skin(4)|ovary(2)|urinary_tract(1)	7						TCCAGTCAAAGAGGCGGCTGT	0.547		NaN											0	0	0	0.001168	0	6	52									
MBD6	114785	broad.mit.edu	37	12	57920498	57920498	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr12:57920498G>A	uc001soj.1	+	7	1794	c.1570G>A	c.(1570-1572)GAG>AAG	p.E524K	MBD6_uc001sok.1_Missense_Mutation_p.E391K|MBD6_uc001sol.1_RNA	NM_052897	NP_443129	Q96DN6	MBD6_HUMAN	methyl-CpG binding domain protein 6	524	Pro-rich.					chromosome|nucleus	chromatin binding|DNA binding			central_nervous_system(3)|ovary(1)	4						CCCCAGCCCTGAGCAGGGCCT	0.652		NaN											0	0	0	0.00278	0	24	84									
OS9	10956	broad.mit.edu	37	12	58114292	58114292	+	Silent	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr12:58114292C>T	uc001spj.2	+	14	1928	c.1869C>T	c.(1867-1869)TTC>TTT	p.F623F	OS9_uc010srx.1_Silent_p.F362F|OS9_uc001spk.2_Silent_p.F608F|OS9_uc001spl.2_Silent_p.F568F|OS9_uc001spm.2_Silent_p.F553F|OS9_uc001spn.2_Silent_p.F569F|OS9_uc010sry.1_Silent_p.F536F|OS9_uc010srz.1_Silent_p.F494F	NM_006812	NP_006803	Q13438	OS9_HUMAN	osteosarcoma amplified 9, endoplasmic reticulum	623					ER-associated protein catabolic process|protein retention in ER lumen|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to endoplasmic reticulum stress	endoplasmic reticulum lumen|Hrd1p ubiquitin ligase complex	glycoprotein binding|protein binding|sugar binding			ovary(1)	1	all_neural(12;0.00548)|Glioma(12;0.0126)|Melanoma(17;0.122)		BRCA - Breast invasive adenocarcinoma(9;0.109)			AGATCTTCTTCAATATCTTGG	0.299		NaN											0	0	0	0.000602	0	5	51									
RAP1B	5908	broad.mit.edu	37	12	69044231	69044231	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr12:69044231G>C	uc001sub.2	+	3	272	c.109G>C	c.(109-111)GAA>CAA	p.E37Q	RAP1B_uc010ste.1_Intron|RAP1B_uc001suc.2_Missense_Mutation_p.E37Q|RAP1B_uc010stf.1_Missense_Mutation_p.E37Q|RAP1B_uc010stg.1_Intron|RAP1B_uc010sth.1_Intron|RAP1B_uc010sti.1_Missense_Mutation_p.E37Q	NM_001089704	NP_001083173	P61224	RAP1B_HUMAN	SubName: Full=Ras-related protein Rap-1A; SubName: Full=cDNA FLJ75985, highly similar to Homo sapiens RAP1A, member of RAS oncogene family (RAP1A), transcript variant 2, mRNA; SubName: Full=RAP1A, member of RAS oncogene family;	37	Effector region (Probable).			E->A: Strong reduction in nucleotide exchange with EPAC2.	blood coagulation|energy reserve metabolic process|regulation of establishment of cell polarity|regulation of insulin secretion	cell-cell junction|cytosol	GDP binding|GTP binding|GTPase activity|protein binding				0	Breast(13;1.24e-05)		Lung(24;0.000131)|LUAD - Lung adenocarcinoma(15;0.00107)|STAD - Stomach adenocarcinoma(21;0.00694)	GBM - Glioblastoma multiforme(7;0.000306)		TCCTACGATAGAAGATTCTTA	0.234		NaN											0	0	0	0.00308	0	6	50									
NUP107	57122	broad.mit.edu	37	12	69126474	69126474	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr12:69126474G>T	uc001suf.2	+	23	2171	c.2056G>T	c.(2056-2058)GCA>TCA	p.A686S	NUP107_uc001sug.2_Missense_Mutation_p.A445S|NUP107_uc010stj.1_Missense_Mutation_p.A657S	NM_020401	NP_065134	P57740	NU107_HUMAN	nucleoporin 107kDa	686					carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA export from nucleus|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytosol|Nup107-160 complex	nucleocytoplasmic transporter activity|protein binding			skin(1)	1	Breast(13;6.25e-06)		Lung(24;0.000131)|LUAD - Lung adenocarcinoma(15;0.00107)|STAD - Stomach adenocarcinoma(21;0.00694)			AGCGCAGAGGGCAGAAGCACT	0.274		NaN											1	0	4.26978e-12	0.00333	4.44117e-12	22	43									
BEST3	144453	broad.mit.edu	37	12	70088210	70088210	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr12:70088210C>G	uc001svg.2	-	3	414	c.187G>C	c.(187-189)GAA>CAA	p.E63Q	BEST3_uc001svd.1_Missense_Mutation_p.E63Q|BEST3_uc001sve.1_Intron|BEST3_uc010stm.1_Intron|BEST3_uc001svh.2_Intron|BEST3_uc001svi.1_Intron	NM_032735	NP_116124	Q8N1M1	BEST3_HUMAN	vitelliform macular dystrophy 2-like 3 isoform	63	Extracellular (Potential).					chloride channel complex|plasma membrane	chloride channel activity				0	Breast(13;2.31e-06)|Esophageal squamous(21;0.187)		Lung(24;0.000278)|OV - Ovarian serous cystadenocarcinoma(12;0.0019)|STAD - Stomach adenocarcinoma(21;0.00694)			GATAATTTTTCAAAGTAACGT	0.378		NaN											0	0	0	0.00308	0	8	41									
KCNC2	3747	broad.mit.edu	37	12	75437006	75437006	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr12:75437006C>T	uc001sxg.1	-	5	2340	c.1796G>A	c.(1795-1797)CGA>CAA	p.R599Q	KCNC2_uc009zry.2_Intron|KCNC2_uc001sxe.2_Intron|KCNC2_uc001sxf.2_Intron|KCNC2_uc010stw.1_Missense_Mutation_p.R544Q	NM_139137	NP_631875	Q96PR1	KCNC2_HUMAN	Shaw-related voltage-gated potassium channel	599	Cytoplasmic (Potential).				energy reserve metabolic process|regulation of insulin secretion	voltage-gated potassium channel complex	voltage-gated potassium channel activity			breast(2)|pancreas(2)|skin(1)|lung(1)	6						GTTTAAGCTTCGGGATTTTTC	0.433		NaN											0	0	0	0.001855	0	12	72									
LRRIQ1	84125	broad.mit.edu	37	12	85547824	85547824	+	Silent	SNP	T	T	C			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr12:85547824T>C	uc001tac.2	+	23	4783	c.4672T>C	c.(4672-4674)TTG>CTG	p.L1558L		NM_001079910	NP_001073379	Q96JM4	LRIQ1_HUMAN	leucine-rich repeats and IQ motif containing 1	1558										ovary(4)|central_nervous_system(1)|skin(1)	6				GBM - Glioblastoma multiforme(134;0.212)		TCAGCAAATGTTGAAGAGGGC	0.289		NaN											0	0	0	0.008291	0	9	28									
DUSP6	1848	broad.mit.edu	37	12	89743278	89743278	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr12:89743278G>A	uc001tay.2	-	3	1379	c.899C>T	c.(898-900)TCA>TTA	p.S300L	DUSP6_uc001taz.2_Missense_Mutation_p.S154L	NM_001946	NP_001937	Q16828	DUS6_HUMAN	dual specificity phosphatase 6 isoform a	300	Tyrosine-protein phosphatase.				dorsal/ventral pattern formation|inactivation of MAPK activity|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of ERK1 and ERK2 cascade|nerve growth factor receptor signaling pathway|positive regulation of apoptosis|regulation of endodermal cell fate specification|regulation of fibroblast growth factor receptor signaling pathway|regulation of heart growth|response to nitrosative stress|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	MAP kinase tyrosine/serine/threonine phosphatase activity|protein tyrosine phosphatase activity				0						CACAGTGACTGAGCGGCTAAT	0.458		NaN											0	0	0	0.003755	0	35	99									
ATP2B1	490	broad.mit.edu	37	12	90005096	90005096	+	Silent	SNP	G	G	C			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr12:90005096G>C	uc001tbh.2	-	12	2302	c.2121C>G	c.(2119-2121)GTC>GTG	p.V707V	ATP2B1_uc001tbg.2_Silent_p.V707V|ATP2B1_uc001tbf.2_Silent_p.V377V	NM_001682	NP_001673	P20020	AT2B1_HUMAN	plasma membrane calcium ATPase 1 isoform 1b	707	Cytoplasmic (Potential).				ATP biosynthetic process|platelet activation	integral to plasma membrane	ATP binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding|protein binding			ovary(2)|central_nervous_system(1)	3						TATCACCAGTGACCATCCGCA	0.358		NaN											0	0	0	0.01441	0	67	410									
TMCC3	57458	broad.mit.edu	37	12	94965382	94965382	+	Silent	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr12:94965382G>A	uc001tdj.2	-	4	1381	c.1263C>T	c.(1261-1263)TTC>TTT	p.F421F	TMCC3_uc001tdi.2_Silent_p.F390F	NM_020698	NP_065749	Q9ULS5	TMCC3_HUMAN	transmembrane and coiled-coil domain family 3	421	Helical; (Potential).					integral to membrane				ovary(1)|skin(1)	2						TGACAGTCATGAAGGCCAGGA	0.532		NaN											0	0	0	0.008361	0	29	75									
C12orf48	55010	broad.mit.edu	37	12	102559617	102559617	+	Silent	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr12:102559617C>T	uc001tjf.2	+	6	889	c.777C>T	c.(775-777)TTC>TTT	p.F259F	C12orf48_uc001tjg.2_Silent_p.F178F|C12orf48_uc010swa.1_Silent_p.F336F|C12orf48_uc001tjh.2_Silent_p.F178F|C12orf48_uc010swb.1_Silent_p.F145F|C12orf48_uc009zuc.2_Intron|C12orf48_uc001tjj.2_5'UTR|C12orf48_uc001tjk.2_Silent_p.F259F|C12orf48_uc009zud.2_Silent_p.F259F	NM_017915	NP_060385	Q9NWS1	PR1BP_HUMAN	hypothetical protein LOC55010	259					response to DNA damage stimulus	cytoplasm|nucleus	DNA binding				0						TTATTAATTTCATTGACAAAT	0.303		NaN											0	0	0	0.012319	0	23	166									
SLC41A2	84102	broad.mit.edu	37	12	105282830	105282830	+	Silent	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr12:105282830G>A	uc001tla.2	-	4	1028	c.861C>T	c.(859-861)TTC>TTT	p.F287F		NM_032148	NP_115524	Q96JW4	S41A2_HUMAN	solute carrier family 41, member 2	287	Helical; (Potential).					integral to membrane|plasma membrane	magnesium ion transmembrane transporter activity			ovary(1)|skin(1)	2						GAGATGCAATGAAGGCAGTTG	0.353		NaN											0	0	0	0.01441	0	59	154									
KIAA1033	23325	broad.mit.edu	37	12	105558049	105558049	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr12:105558049G>A	uc001tld.2	+	31	3405	c.3318G>A	c.(3316-3318)ATG>ATA	p.M1106I	KIAA1033_uc010swr.1_Missense_Mutation_p.M1107I|KIAA1033_uc010sws.1_Missense_Mutation_p.M918I	NM_015275	NP_056090	Q2M389	WAHS7_HUMAN	hypothetical protein LOC23325	1106					endosome transport	WASH complex				kidney(1)|central_nervous_system(1)	2						TACAAACCATGAATCTCACTC	0.408		NaN											0	0	0	0.001855	0	14	52									
NAA25	80018	broad.mit.edu	37	12	112477111	112477111	+	Nonsense_Mutation	SNP	G	G	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr12:112477111G>T	uc001ttm.2	-	22	2591	c.2571C>A	c.(2569-2571)TAC>TAA	p.Y857*	NAA25_uc001ttn.3_RNA|NAA25_uc009zvz.1_Nonsense_Mutation_p.Y829*|NAA25_uc009zwa.1_Nonsense_Mutation_p.Y835*	NM_024953	NP_079229	Q14CX7	NAA25_HUMAN	mitochondrial distribution and morphology 20	857						cytoplasm	protein binding			ovary(1)|breast(1)|pancreas(1)	3						CACTCTCACAGTAACTGGATA	0.328		NaN											1	0	1.52319e-26	0.00874	1.61096e-26	40	101									
C12orf51	283450	broad.mit.edu	37	12	112608964	112608964	+	Silent	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr12:112608964G>A	uc009zwc.2	-	61	10641	c.10623C>T	c.(10621-10623)CCC>CCT	p.P3541P		NM_001109662	NP_001103132			chromosome 12 open reading frame 51											ovary(1)|lung(1)	2						GGGTATACATGGGTGTCTGGC	0.632		NaN											0	0	0	0.001168	0	5	17									
C12orf52	84934	broad.mit.edu	37	12	113629482	113629482	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr12:113629482C>G	uc001tur.1	+	4	1138	c.670C>G	c.(670-672)CAG>GAG	p.Q224E	C12orf52_uc009zwg.1_Missense_Mutation_p.Q221E|C12orf52_uc001tus.1_Missense_Mutation_p.Q224E|C12orf52_uc001tut.1_Missense_Mutation_p.Q248E	NM_032848	NP_116237	Q96K30	RITA_HUMAN	hypothetical protein LOC84934	224	Interaction with tubulin.				negative regulation of Notch signaling pathway|negative regulation of transcription from RNA polymerase II promoter|neurogenesis|Notch signaling pathway|nuclear export	centrosome|nucleus	tubulin binding				0						AAATGGGCCTCAGGATCTCAG	0.617		NaN											0	0	0	0.008291	0	10	55									
MED13L	23389	broad.mit.edu	37	12	116549237	116549237	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr12:116549237C>G	uc001tvw.2	-	3	446	c.391G>C	c.(391-393)GAA>CAA	p.E131Q		NM_015335	NP_056150	Q71F56	MD13L_HUMAN	mediator complex subunit 13-like	131					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent					skin(4)|ovary(2)|upper_aerodigestive_tract(1)|lung(1)	8	all_neural(191;0.117)|Medulloblastoma(191;0.163)			BRCA - Breast invasive adenocarcinoma(302;0.0407)		TCTTACCTTTCTAACAGATTG	0.383		NaN											0	0	0	0.001855	0	13	114									
CIT	11113	broad.mit.edu	37	12	120221778	120221778	+	Silent	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr12:120221778C>T	uc001txi.1	-	12	1532	c.1479G>A	c.(1477-1479)CTG>CTA	p.L493L	CIT_uc001txh.1_Silent_p.L27L|CIT_uc001txj.1_Silent_p.L493L	NM_007174	NP_009105	O14578	CTRO_HUMAN	citron	493	Potential.				intracellular signal transduction		ATP binding|metal ion binding|protein serine/threonine kinase activity|SH3 domain binding|small GTPase regulator activity			ovary(6)|urinary_tract(1)|lung(1)|breast(1)|skin(1)	10	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)	Myeloproliferative disorder(1001;0.0255)		BRCA - Breast invasive adenocarcinoma(302;0.211)		CAGAGGCCTTCAGCTCCACCT	0.542		NaN											0	0	0	0.01441	0	62	273									
HIP1R	9026	broad.mit.edu	37	12	123342655	123342655	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr12:123342655C>G	uc001udj.1	+	19	1881	c.1822C>G	c.(1822-1824)CAG>GAG	p.Q608E	HIP1R_uc001udk.1_5'UTR	NM_003959	NP_003950	O75146	HIP1R_HUMAN	huntingtin interacting protein-1-related	608					receptor-mediated endocytosis	clathrin coated vesicle membrane|coated pit|perinuclear region of cytoplasm	actin binding|phosphatidylinositol binding			ovary(1)	1	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;4.6e-05)|Epithelial(86;0.000119)|BRCA - Breast invasive adenocarcinoma(302;0.2)		CCAGGAGTCTCAGGAGCAGGG	0.652		NaN											0	0	0	0.00499	0	11	91									
CHFR	55743	broad.mit.edu	37	12	133428210	133428210	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr12:133428210G>A	uc001ulf.2	-	12	1606	c.1522C>T	c.(1522-1524)CAG>TAG	p.Q508*	CHFR_uc001ulc.1_RNA|CHFR_uc001ule.2_Nonsense_Mutation_p.Q496*|CHFR_uc010tbs.1_Nonsense_Mutation_p.Q507*|CHFR_uc001uld.2_Nonsense_Mutation_p.Q467*|CHFR_uc010tbt.1_Nonsense_Mutation_p.Q416*	NM_001161344	NP_001154816	Q96EP1	CHFR_HUMAN	checkpoint with forkhead and ring finger domains	508					cell division|mitosis|mitotic cell cycle checkpoint|modification-dependent protein catabolic process|protein polyubiquitination	PML body	nucleotide binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			skin(1)	1	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_cancers(7;0.00552)|all_epithelial(31;0.226)		OV - Ovarian serous cystadenocarcinoma(86;2.59e-08)|Epithelial(86;6.38e-07)|all cancers(50;1.56e-05)		TCACACTGCTGAGGGGCGACA	0.657		NaN											0	0	0	0.01441	0	54	163									
PSPC1	55269	broad.mit.edu	37	13	20283725	20283725	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr13:20283725C>T	uc001uml.2	-	7	1359	c.1173G>A	c.(1171-1173)ATG>ATA	p.M391I	PSPC1_uc001umj.1_Intron|PSPC1_uc001umk.1_Intron	NM_001042414	NP_001035879	Q8WXF1	PSPC1_HUMAN	paraspeckle protein 1	391					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nuclear matrix|nucleolus	nucleotide binding|protein binding|RNA binding			breast(1)	1		all_cancers(29;1.25e-22)|all_lung(29;1.97e-20)|all_epithelial(30;2.29e-20)|Lung NSC(5;3.36e-17)|Lung SC(185;0.0262)|Ovarian(182;0.162)		all cancers(112;4.63e-06)|Epithelial(112;2.29e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00256)|Lung(94;0.00975)|LUSC - Lung squamous cell carcinoma(192;0.0483)		CACCCATTCTCATTTCCTGTT	0.373		NaN											0	0	0	0.01441	0	50	115									
SACS	26278	broad.mit.edu	37	13	23904719	23904719	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr13:23904719G>C	uc001uon.2	-	10	13885	c.13296C>G	c.(13294-13296)TTC>TTG	p.F4432L	SACS_uc001uoo.2_Missense_Mutation_p.F4285L|SACS_uc001uop.1_Intron|SACS_uc001uoq.1_Intron	NM_014363	NP_055178	Q9NZJ4	SACS_HUMAN	sacsin	4432					cell death|negative regulation of inclusion body assembly|protein folding	axon|cell body fiber|dendrite|mitochondrion|nucleus	ATP binding|chaperone binding|Hsp70 protein binding|proteasome binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		all_cancers(29;1.51e-22)|all_epithelial(30;7.82e-19)|all_lung(29;4.71e-18)|Lung SC(185;0.0225)|Breast(139;0.128)		all cancers(112;0.00197)|Epithelial(112;0.00854)|OV - Ovarian serous cystadenocarcinoma(117;0.0298)|Lung(94;0.189)		GAGGAACAAAGAACCTTTGAG	0.478		NaN											0	0	0	0.007835	0	42	112									
SACS	26278	broad.mit.edu	37	13	23904867	23904867	+	Nonsense_Mutation	SNP	G	G	C			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr13:23904867G>C	uc001uon.2	-	10	13737	c.13148C>G	c.(13147-13149)TCA>TGA	p.S4383*	SACS_uc001uoo.2_Nonsense_Mutation_p.S4236*|SACS_uc001uop.1_Intron|SACS_uc001uoq.1_Intron	NM_014363	NP_055178	Q9NZJ4	SACS_HUMAN	sacsin	4383	J.				cell death|negative regulation of inclusion body assembly|protein folding	axon|cell body fiber|dendrite|mitochondrion|nucleus	ATP binding|chaperone binding|Hsp70 protein binding|proteasome binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		all_cancers(29;1.51e-22)|all_epithelial(30;7.82e-19)|all_lung(29;4.71e-18)|Lung SC(185;0.0225)|Breast(139;0.128)		all cancers(112;0.00197)|Epithelial(112;0.00854)|OV - Ovarian serous cystadenocarcinoma(117;0.0298)|Lung(94;0.189)		TCGGGATGCTGAGGTTGAAAA	0.378		NaN											0	0	0	0.009718	0	45	135									
SACS	26278	broad.mit.edu	37	13	23905173	23905173	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr13:23905173G>C	uc001uon.2	-	10	13431	c.12842C>G	c.(12841-12843)TCT>TGT	p.S4281C	SACS_uc001uoo.2_Missense_Mutation_p.S4134C|SACS_uc001uop.1_Intron|SACS_uc001uoq.1_Intron	NM_014363	NP_055178	Q9NZJ4	SACS_HUMAN	sacsin	4281					cell death|negative regulation of inclusion body assembly|protein folding	axon|cell body fiber|dendrite|mitochondrion|nucleus	ATP binding|chaperone binding|Hsp70 protein binding|proteasome binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		all_cancers(29;1.51e-22)|all_epithelial(30;7.82e-19)|all_lung(29;4.71e-18)|Lung SC(185;0.0225)|Breast(139;0.128)		all cancers(112;0.00197)|Epithelial(112;0.00854)|OV - Ovarian serous cystadenocarcinoma(117;0.0298)|Lung(94;0.189)		CTCTCTACCAGAGAAAAGAGG	0.478		NaN											0	0	0	0.007291	0	29	84									
USP12	219333	broad.mit.edu	37	13	27645266	27645266	+	Missense_Mutation	SNP	T	T	C			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr13:27645266T>C	uc001uqy.2	-	8	1206	c.953A>G	c.(952-954)TAT>TGT	p.Y318C		NM_182488	NP_872294	O75317	UBP12_HUMAN	ubiquitin thiolesterase 12	318					protein deubiquitination|ubiquitin-dependent protein catabolic process		cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			lung(1)	1		Lung SC(185;0.0161)		all cancers(112;0.0508)|GBM - Glioblastoma multiforme(144;0.168)|Epithelial(112;0.244)|OV - Ovarian serous cystadenocarcinoma(117;0.246)		TATTGCAATATAATGGCCTCG	0.274		NaN											0	0	0	0.001855	0	12	68									
CCNA1	8900	broad.mit.edu	37	13	37011849	37011849	+	Silent	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr13:37011849C>T	uc001uvr.3	+	3	731	c.381C>T	c.(379-381)GTC>GTT	p.V127V	CCNA1_uc010teo.1_Silent_p.V83V|CCNA1_uc010abq.2_Silent_p.V83V|CCNA1_uc010abp.2_Silent_p.V83V|CCNA1_uc001uvs.3_Silent_p.V126V|CCNA1_uc010abr.2_RNA	NM_003914	NP_003905	P78396	CCNA1_HUMAN	cyclin A1 isoform a	127					cell division|G2/M transition of mitotic cell cycle|male meiosis I|mitosis|regulation of cyclin-dependent protein kinase activity|regulation of transcription involved in G1/S phase of mitotic cell cycle|spermatogenesis	cytosol|microtubule cytoskeleton|nucleoplasm	protein kinase binding			lung(2)|skin(2)|ovary(1)	5		Breast(139;0.014)|Lung SC(185;0.0548)|Prostate(109;0.174)	KIRC - Kidney renal clear cell carcinoma(5;0.119)|Kidney(79;0.169)	all cancers(112;1.91e-07)|Epithelial(112;1.22e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00623)|BRCA - Breast invasive adenocarcinoma(63;0.0119)|GBM - Glioblastoma multiforme(144;0.0242)		ACTGTGGGGTCCAAGAGCCCC	0.498		NaN											0	0	0	0.009535	0	32	74									
CCDC70	83446	broad.mit.edu	37	13	52439716	52439716	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr13:52439716G>C	uc001vfu.3	+	2	498	c.202G>C	c.(202-204)GAG>CAG	p.E68Q	uc010tgr.1_RNA	NM_031290	NP_112580	Q6NSX1	CCD70_HUMAN	coiled-coil domain containing 70 precursor	68						extracellular region|plasma membrane					0		Breast(56;0.000207)|Lung NSC(96;0.00145)|Prostate(109;0.0107)|Hepatocellular(98;0.065)|all_neural(104;0.19)		GBM - Glioblastoma multiforme(99;2.4e-08)		CTTCAGGGAAGAGATGTGGAC	0.468		NaN											0	0	0	0.013537	0	12	89									
TMTC4	84899	broad.mit.edu	37	13	101278119	101278119	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr13:101278119C>G	uc001vou.2	-	13	1717	c.1557G>C	c.(1555-1557)ATG>ATC	p.M519I	TMTC4_uc001vot.2_Missense_Mutation_p.M538I|TMTC4_uc010tja.1_Missense_Mutation_p.M408I|TMTC4_uc001vov.1_Missense_Mutation_p.M264I|TMTC4_uc001vow.1_Missense_Mutation_p.M302I	NM_001079669	NP_001073137	Q5T4D3	TMTC4_HUMAN	transmembrane and tetratricopeptide repeat	519	TPR 3.					integral to membrane	binding			ovary(2)|breast(1)	3	all_neural(89;0.0837)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)					CAAGATTATTCATGGCATGAA	0.343		NaN											0	0	0	0.006122	0	16	56									
COL4A2	1284	broad.mit.edu	37	13	111077333	111077333	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr13:111077333G>A	uc001vqx.2	+	6	638	c.349G>A	c.(349-351)GAT>AAT	p.D117N		NM_001846	NP_001837	P08572	CO4A2_HUMAN	alpha 2 type IV collagen preproprotein	117					angiogenesis|axon guidance|extracellular matrix organization|negative regulation of angiogenesis	collagen type IV	extracellular matrix structural constituent|protein binding			skin(3)|central_nervous_system(2)|ovary(1)	6	all_cancers(4;2.21e-12)|all_epithelial(4;2.63e-07)|all_lung(23;5.81e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00323)|all_neural(89;0.0565)|Lung SC(71;0.0753)|Medulloblastoma(90;0.0922)	Breast(118;0.212)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.151)			CCCTGGTGCCGATGGAATTCC	0.433		NaN											0	0	0	0.00308	0	7	72									
C13orf16	121793	broad.mit.edu	37	13	111973258	111973258	+	Silent	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr13:111973258G>A	uc001vsa.2	+	2	150	c.21G>A	c.(19-21)GTG>GTA	p.V7V		NM_152324	NP_689537	Q8N6K0	CM016_HUMAN	hypothetical protein LOC121793	7	Extracellular (Potential).					integral to membrane					0	all_lung(23;3.96e-05)|Lung NSC(43;0.00156)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Medulloblastoma(90;0.163)		all cancers(43;0.113)|GBM - Glioblastoma multiforme(44;0.174)|BRCA - Breast invasive adenocarcinoma(86;0.188)			TGCTGGAAGTGAAGAACTCTC	0.652		NaN											0	0	0	0.012319	0	18	45									
OR4K5	79317	broad.mit.edu	37	14	20389242	20389242	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr14:20389242G>T	uc010tkw.1	+	1	477	c.477G>T	c.(475-477)CAG>CAT	p.Q159H		NM_001005483	NP_001005483	Q8NGD3	OR4K5_HUMAN	olfactory receptor, family 4, subfamily K,	159	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		CATTAAGCCAGTTATCATTTA	0.448		NaN											1	0	3.54119e-60	0.01441	3.77242e-60	142	767									
RPGRIP1	57096	broad.mit.edu	37	14	21780010	21780010	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr14:21780010G>A	uc001wag.2	+	8	958	c.958G>A	c.(958-960)GAG>AAG	p.E320K		NM_020366	NP_065099	Q96KN7	RPGR1_HUMAN	retinitis pigmentosa GTPase regulator	320	Potential.				response to stimulus|visual perception	cilium				ovary(4)|breast(2)|pancreas(1)	7	all_cancers(95;0.0017)	all_cancers(140;0.0973)	Epithelial(56;6.24e-07)|all cancers(55;6.56e-06)	GBM - Glioblastoma multiforme(265;0.00888)		TGCAGCCCATGAGGCCCTCCT	0.512		NaN											0	0	0	0.000602	0	5	11									
RPGRIP1	57096	broad.mit.edu	37	14	21780081	21780081	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr14:21780081G>C	uc001wag.2	+	8	1029	c.1029G>C	c.(1027-1029)TTG>TTC	p.L343F		NM_020366	NP_065099	Q96KN7	RPGR1_HUMAN	retinitis pigmentosa GTPase regulator	343	Potential.				response to stimulus|visual perception	cilium				ovary(4)|breast(2)|pancreas(1)	7	all_cancers(95;0.0017)	all_cancers(140;0.0973)	Epithelial(56;6.24e-07)|all cancers(55;6.56e-06)	GBM - Glioblastoma multiforme(265;0.00888)		CTGTGAGCTTGAAGAGCCAAC	0.453		NaN											0	0	0	0.008291	0	11	11									
FBXO33	254170	broad.mit.edu	37	14	39868857	39868857	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr14:39868857G>A	uc001wvk.2	-	4	1869	c.1531C>T	c.(1531-1533)CAT>TAT	p.H511Y		NM_203301	NP_976046	Q7Z6M2	FBX33_HUMAN	F-box protein 33	511											0	Hepatocellular(127;0.213)		LUAD - Lung adenocarcinoma(48;0.00107)|Lung(238;0.00121)|Epithelial(34;0.169)	GBM - Glioblastoma multiforme(112;0.0425)		ATAAGGTTATGCACTGGATCT	0.488		NaN											0	0	0	0.008291	0	9	26									
FAM179B	23116	broad.mit.edu	37	14	45433564	45433564	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr14:45433564G>A	uc001wvv.2	+	1	2149	c.1940G>A	c.(1939-1941)CGA>CAA	p.R647Q	FAM179B_uc001wvw.2_Missense_Mutation_p.R647Q|FAM179B_uc010anc.2_RNA|KLHL28_uc001wvr.2_5'Flank|FAM179B_uc010anb.1_Missense_Mutation_p.R647Q|FAM179B_uc001wvu.2_Missense_Mutation_p.R647Q	NM_015091	NP_055906	Q9Y4F4	F179B_HUMAN	hypothetical protein LOC23116	647							binding			skin(2)|upper_aerodigestive_tract(1)	3						ATCTGTACCCGAAGGGTATTA	0.443		NaN											0	0	0	0.003163	0	16	44									
FAM179B	23116	broad.mit.edu	37	14	45542646	45542646	+	Nonsense_Mutation	SNP	C	C	G			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr14:45542646C>G	uc001wvv.2	+	19	5254	c.5045C>G	c.(5044-5046)TCA>TGA	p.S1682*	FAM179B_uc001wvw.2_Nonsense_Mutation_p.S1735*|FAM179B_uc010anc.2_RNA	NM_015091	NP_055906	Q9Y4F4	F179B_HUMAN	hypothetical protein LOC23116	1682							binding			skin(2)|upper_aerodigestive_tract(1)	3						GCTAAATTATCAAAAGCACTC	0.403		NaN											0	0	0	0.012319	0	19	58									
TMX1	81542	broad.mit.edu	37	14	51707163	51707163	+	Splice_Site	SNP	G	G	C			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr14:51707163G>C	uc001wza.3	+	1	277	c.152_splice	c.e1+1	p.F51_splice	TMX1_uc010tqr.1_Splice_Site_p.F51_splice|TMX1_uc010aoa.2_Splice_Site	NM_030755	NP_110382	Q9H3N1	TMX1_HUMAN	thioredoxin domain containing 1 precursor						anti-apoptosis|cell proliferation|cell redox homeostasis|DNA replication|electron transport chain|ER to Golgi vesicle-mediated transport|leukocyte activation|positive regulation of growth|positive regulation of transcription, DNA-dependent|response to stress|signal transduction	endoplasmic reticulum membrane|integral to membrane|membrane fraction	arsenate reductase (thioredoxin) activity|disulfide oxidoreductase activity				0						TGATAGAATTGTGAGTGCGGG	0.647		NaN											0	0	0	0.004672	0	3	15									
ZFP36L1	677	broad.mit.edu	37	14	69256711	69256711	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr14:69256711C>T	uc001xkh.1	-	2	686	c.556G>A	c.(556-558)GCC>ACC	p.A186T	ZFP36L1_uc001xki.1_Missense_Mutation_p.A186T	NM_004926	NP_004917	Q07352	TISB_HUMAN	butyrate response factor 1	186					regulation of mRNA stability	cytosol|nucleus	DNA binding|mRNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1				all cancers(60;0.00203)|BRCA - Breast invasive adenocarcinoma(234;0.00205)|OV - Ovarian serous cystadenocarcinoma(108;0.0401)		CGGGCCCCGGCCAGGGCACGG	0.572		NaN									OREG0022753	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.001984	0	6	32									
YLPM1	56252	broad.mit.edu	37	14	75231008	75231008	+	Silent	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr14:75231008G>A	uc001xqj.3	+	1	940	c.816G>A	c.(814-816)AAG>AAA	p.K272K		NM_019589	NP_062535	P49750	YLPM1_HUMAN	YLP motif containing 1	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear speck				ovary(2)|pancreas(1)	3			KIRC - Kidney renal clear cell carcinoma(43;0.238)	BRCA - Breast invasive adenocarcinoma(234;0.00162)		CCAAAAACAAGAGTACTGAAC	0.532		NaN											0	0	0	0.001168	0	5	11									
C14orf174	161394	broad.mit.edu	37	14	77846794	77846794	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr14:77846794G>T	uc001xtq.1	+	2	1758	c.1758G>T	c.(1756-1758)CAG>CAT	p.Q586H		NM_001010860	NP_001010860	Q9P1V8	SAM15_HUMAN	hypothetical protein LOC161394	586	SAM.										0			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0278)		ACCTCCCTCAGATGGGGATAA	0.423		NaN											1	0	1.61879e-10	0.013537	1.67783e-10	12	28									
PTPN21	11099	broad.mit.edu	37	14	88946469	88946469	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr14:88946469G>A	uc001xwv.3	-	13	1637	c.1306C>T	c.(1306-1308)CGG>TGG	p.R436W	PTPN21_uc010twc.1_Missense_Mutation_p.R232W	NM_007039	NP_008970	Q16825	PTN21_HUMAN	protein tyrosine phosphatase, non-receptor type	436						cytoplasm|cytoskeleton	binding|protein tyrosine phosphatase activity			ovary(3)|skin(1)	4						GCGCTGTGCCGATGGGACGGG	0.607		NaN											0	0	0	0.006214	0	9	30									
TDP1	55775	broad.mit.edu	37	14	90429474	90429474	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr14:90429474G>A	uc001xxy.2	+	3	315	c.16G>A	c.(16-18)GAT>AAT	p.D6N	TDP1_uc010atm.2_RNA|TDP1_uc001xxz.2_Missense_Mutation_p.D6N|TDP1_uc010atn.2_Missense_Mutation_p.D6N|TDP1_uc001xya.2_5'UTR|TDP1_uc001xyb.2_RNA|TDP1_uc010ato.2_Missense_Mutation_p.D6N|TDP1_uc001xyc.1_Missense_Mutation_p.D6N	NM_018319	NP_060789	Q9NUW8	TYDP1_HUMAN	tyrosyl-DNA phosphodiesterase 1	6					cell death|double-strand break repair|single strand break repair	cytoplasm|nucleus	3'-tyrosyl-DNA phosphodiesterase activity|double-stranded DNA binding|exonuclease activity|protein binding|single-stranded DNA binding			ovary(2)	2		all_cancers(154;0.185)		COAD - Colon adenocarcinoma(157;0.23)		TCAGGAAGGCGATTATGGGAG	0.433		NaN						Repair_of_DNA-protein_crosslinks					0	0	0	0.010504	0	19	69									
CATSPERB	79820	broad.mit.edu	37	14	92139220	92139220	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr14:92139220G>T	uc001xzs.1	-	13	1259	c.1119C>A	c.(1117-1119)TTC>TTA	p.F373L	CATSPERB_uc010aub.1_5'Flank	NM_024764	NP_079040	Q9H7T0	CTSRB_HUMAN	cation channel, sperm-associated, beta	373					cell differentiation|multicellular organismal development|spermatogenesis	integral to membrane				breast(2)|skin(2)|ovary(1)	5		all_cancers(154;0.0663)|all_epithelial(191;0.236)				CCTTGTTATAGAAGAGGTAAA	0.353		NaN											1	0	5.82218e-30	0.01441	6.17249e-30	57	192									
PAPOLA	10914	broad.mit.edu	37	14	97003330	97003330	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr14:97003330G>A	uc001yfq.2	+	12	1258	c.1048G>A	c.(1048-1050)GAA>AAA	p.E350K	PAPOLA_uc001yfr.2_Missense_Mutation_p.E350K|PAPOLA_uc010twv.1_Missense_Mutation_p.E350K|PAPOLA_uc010avp.2_Missense_Mutation_p.E100K	NM_032632	NP_116021	P51003	PAPOA_HUMAN	poly(A) polymerase alpha	350					mRNA polyadenylation|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	cytoplasm|nucleoplasm	ATP binding|magnesium ion binding|manganese ion binding|polynucleotide adenylyltransferase activity|RNA binding				0		all_cancers(154;0.0555)|all_epithelial(191;0.149)|Melanoma(154;0.155)		COAD - Colon adenocarcinoma(157;0.213)		TATCACAGATGAAATTTTGCT	0.318		NaN											0	0	0	0.010729	0	11	43									
DYNC1H1	1778	broad.mit.edu	37	14	102514870	102514870	+	Silent	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr14:102514870C>T	uc001yks.2	+	74	13400	c.13236C>T	c.(13234-13236)TTC>TTT	p.F4412F		NM_001376	NP_001367	Q14204	DYHC1_HUMAN	cytoplasmic dynein 1 heavy chain 1	4412					cytoplasmic mRNA processing body assembly|G2/M transition of mitotic cell cycle|microtubule-based movement|mitotic spindle organization|stress granule assembly|transport	centrosome|cytoplasmic dynein complex|cytosol|Golgi apparatus|microtubule	ATP binding|ATPase activity, coupled|microtubule motor activity|protein binding			ovary(7)|central_nervous_system(2)|pancreas(1)	10						TGTTCAGGTTCTTTGAGAGAG	0.483		NaN											0	0	0	0.006214	0	9	37									
KLC1	3831	broad.mit.edu	37	14	104121150	104121150	+	Silent	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr14:104121150G>A	uc001yno.2	+	2	557	c.249G>A	c.(247-249)CTG>CTA	p.L83L	KLC1_uc010tyd.1_Silent_p.L242L|KLC1_uc010tye.1_Silent_p.L79L|KLC1_uc001ynm.1_Silent_p.L83L|KLC1_uc001ynn.1_Silent_p.L79L|KLC1_uc010tyf.1_Silent_p.L83L	NM_182923	NP_891553	Q07866	KLC1_HUMAN	kinesin light chain 1 isoform 2	83					blood coagulation|microtubule-based movement|stress granule disassembly	cytosol|kinesin complex|microtubule	microtubule motor activity|protein binding				0		Melanoma(154;0.155)|all_epithelial(191;0.19)				AGCTCGGCCTGAGTGAGGCAC	0.418		NaN											0	0	0	0.004482	0	9	53									
BUB1B	701	broad.mit.edu	37	15	40501871	40501871	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr15:40501871C>T	uc001zkx.3	+	17	2391	c.2179C>T	c.(2179-2181)CGC>TGC	p.R727C		NM_001211	NP_001202	O60566	BUB1B_HUMAN	budding uninhibited by benzimidazoles 1 beta	727					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|cell division|cell proliferation|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|phosphatidylinositol-mediated signaling|protein localization to kinetochore|spindle organization	anaphase-promoting complex|condensed chromosome outer kinetochore|cytosol|microtubule organizing center|perinuclear region of cytoplasm|spindle midzone	ATP binding|protein binding|protein serine/threonine kinase activity			stomach(2)|ovary(1)|kidney(1)	4		all_cancers(109;1.12e-18)|all_epithelial(112;1.61e-15)|Lung NSC(122;5.63e-11)|all_lung(180;1.4e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;1.83e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0556)		TTCACAGTATCGCAGACAGCT	0.418		NaN	Mis|N|F|S			rhabdomyosarcoma			Mosaic_Variegated_Aneuploidy_Syndrome				0	0	0	0.005443	0	25	145									
C15orf52	388115	broad.mit.edu	37	15	40633137	40633137	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr15:40633137C>T	uc001zlh.3	-	1	32	c.16G>A	c.(16-18)GAG>AAG	p.E6K	C15orf52_uc001zli.1_5'Flank	NM_207380	NP_997263	Q6ZUT6	CO052_HUMAN	hypothetical protein LOC388115	6										large_intestine(1)	1		all_cancers(109;9.35e-19)|all_epithelial(112;1.18e-15)|Lung NSC(122;2.45e-11)|all_lung(180;6.47e-10)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;9.06e-06)|Colorectal(105;0.0107)|BRCA - Breast invasive adenocarcinoma(123;0.0505)|READ - Rectum adenocarcinoma(2;0.0649)|Lung(196;0.0781)|LUAD - Lung adenocarcinoma(183;0.0841)		CTTCGCTGCTCAGCACACGAG	0.647		NaN											0	0	0	0.009096	0	3	14									
MAPKBP1	23005	broad.mit.edu	37	15	42107900	42107900	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr15:42107900G>A	uc001zok.3	+	13	1700	c.1414G>A	c.(1414-1416)GAT>AAT	p.D472N	MAPKBP1_uc001zoj.3_Missense_Mutation_p.D466N|MAPKBP1_uc010bcj.2_5'UTR|MAPKBP1_uc010bci.2_Missense_Mutation_p.D466N|MAPKBP1_uc010udb.1_Missense_Mutation_p.D305N|MAPKBP1_uc010bck.2_5'UTR|MAPKBP1_uc010bcl.2_5'UTR	NM_001128608	NP_001122080	O60336	MABP1_HUMAN	mitogen-activated protein kinase binding protein	472										central_nervous_system(5)|breast(2)|upper_aerodigestive_tract(1)|pancreas(1)|skin(1)	10		all_cancers(109;7.71e-14)|all_epithelial(112;5.15e-12)|Lung NSC(122;3.74e-08)|all_lung(180;1.81e-07)|Melanoma(134;0.0262)		OV - Ovarian serous cystadenocarcinoma(18;3.95e-17)|GBM - Glioblastoma multiforme(94;5.71e-07)|Lung(196;0.0436)|BRCA - Breast invasive adenocarcinoma(123;0.203)|LUSC - Lung squamous cell carcinoma(244;0.225)		AGACAAAGCTGATGCATCCCT	0.547		NaN											0	0	0	0.001984	0	7	26									
EHD4	30844	broad.mit.edu	37	15	42193072	42193072	+	Nonsense_Mutation	SNP	G	G	C			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr15:42193072G>C	uc001zot.2	-	6	1460	c.1397C>G	c.(1396-1398)TCA>TGA	p.S466*		NM_139265	NP_644670	Q9H223	EHD4_HUMAN	EH-domain containing 4	466	EH.				endocytic recycling|protein homooligomerization	early endosome membrane|endoplasmic reticulum|nucleus|recycling endosome membrane	ATP binding|calcium ion binding|GTP binding|GTPase activity|nucleic acid binding|protein binding			ovary(2)	2		all_cancers(109;2.54e-12)|all_epithelial(112;6.59e-11)|Lung NSC(122;2.17e-07)|all_lung(180;8.79e-07)|Melanoma(134;0.091)		OV - Ovarian serous cystadenocarcinoma(18;1.6e-19)|GBM - Glioblastoma multiforme(94;3.77e-06)|COAD - Colon adenocarcinoma(120;0.0474)|Colorectal(105;0.0538)		GTTGACACCTGATATCTTGCC	0.597		NaN											0	0	0	0.010729	0	10	51									
CDAN1	146059	broad.mit.edu	37	15	43022925	43022925	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr15:43022925C>T	uc001zql.2	-	14	2162	c.2045G>A	c.(2044-2046)CGA>CAA	p.R682Q	CDAN1_uc001zqj.2_RNA|CDAN1_uc001zqk.2_Missense_Mutation_p.E8K	NM_138477	NP_612486	Q8IWY9	CDAN1_HUMAN	codanin 1	682						integral to membrane	protein binding			ovary(2)	2		all_cancers(109;5.4e-16)|all_epithelial(112;2.97e-14)|Lung NSC(122;1.75e-08)|all_lung(180;5.99e-08)|Melanoma(134;0.0179)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;2.49e-07)		CTGCAGCCCTCGCTGCAGCAG	0.637		NaN											0	0	0	0.00308	0	7	15									
GATM	2628	broad.mit.edu	37	15	45654374	45654374	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr15:45654374C>T	uc001zvc.2	-	9	1534	c.1205G>A	c.(1204-1206)GGA>GAA	p.G402E	GATM_uc001zvb.2_Missense_Mutation_p.G273E	NM_001482	NP_001473	P50440	GATM_HUMAN	L-arginine:glycine amidinotransferase precursor	402					creatine biosynthetic process	mitochondrial inner membrane|mitochondrial intermembrane space	glycine amidinotransferase activity|protein binding				0		all_cancers(109;1.25e-09)|all_epithelial(112;5.56e-08)|Lung NSC(122;3.55e-06)|all_lung(180;2.56e-05)|Melanoma(134;0.027)		all cancers(107;4.87e-16)|GBM - Glioblastoma multiforme(94;1.97e-06)	Creatine(DB00148)|Glycine(DB00145)|L-Ornithine(DB00129)	GAAGCCTCCTCCCAGGGAATT	0.498		NaN											0	0	0	0.00308	0	7	53									
SLC27A2	11001	broad.mit.edu	37	15	50518226	50518226	+	Missense_Mutation	SNP	A	A	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr15:50518226A>T	uc001zxw.2	+	6	1441	c.1209A>T	c.(1207-1209)AAA>AAT	p.K403N	SLC27A2_uc010bes.2_Missense_Mutation_p.K350N|SLC27A2_uc001zxx.2_Missense_Mutation_p.K168N	NM_003645	NP_003636	O14975	S27A2_HUMAN	solute carrier family 27 (fatty acid	403	Cytoplasmic (Potential).				bile acid biosynthetic process|fatty acid alpha-oxidation	endoplasmic reticulum membrane|integral to membrane|peroxisomal matrix|peroxisomal membrane	ATP binding|long-chain fatty acid-CoA ligase activity|phytanate-CoA ligase activity|pristanate-CoA ligase activity			ovary(1)|skin(1)	2		all_lung(180;0.00177)		all cancers(107;1.16e-06)|GBM - Glioblastoma multiforme(94;0.000113)		ATGTGGAGAAAGATGAACCTG	0.318		NaN											0	0	0	0.007835	0	41	104									
MYO5C	55930	broad.mit.edu	37	15	52553307	52553307	+	Silent	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr15:52553307C>T	uc010bff.2	-	10	1202	c.1065G>A	c.(1063-1065)CTG>CTA	p.L355L	MYO5C_uc010uga.1_RNA|MYO5C_uc010ugb.1_RNA|MYO5C_uc010ugc.1_Silent_p.*255*	NM_018728	NP_061198	Q9NQX4	MYO5C_HUMAN	myosin VC	355	Myosin head-like.					myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			ovary(7)|central_nervous_system(3)|large_intestine(2)|skin(2)	14				all cancers(107;0.0137)		AGAACACCTTCAGGTGACTGT	0.572		NaN											0	0	0	0.00333	0	22	54									
RNF111	54778	broad.mit.edu	37	15	59344515	59344515	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr15:59344515G>A	uc002afv.2	+	3	1171	c.892G>A	c.(892-894)GAA>AAA	p.E298K	RNF111_uc002afs.2_Missense_Mutation_p.E298K|RNF111_uc002aft.2_Missense_Mutation_p.E298K|RNF111_uc002afu.2_Missense_Mutation_p.E298K|RNF111_uc002afw.2_Missense_Mutation_p.E298K	NM_017610	NP_060080	Q6ZNA4	RN111_HUMAN	ring finger protein 111	298	Ser-rich.|Interaction with AXIN1.				multicellular organismal development|positive regulation of transcription, DNA-dependent	cytoplasm|nucleus	protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(2)	2				all cancers(107;0.194)		AAGTATTGATGAAGATGTTGT	0.373		NaN											0	0	0	0.004656	0	28	149									
HERC1	8925	broad.mit.edu	37	15	63984612	63984612	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr15:63984612G>A	uc002amp.2	-	31	5976	c.5828C>T	c.(5827-5829)TCA>TTA	p.S1943L		NM_003922	NP_003913	Q15751	HERC1_HUMAN	hect domain and RCC1-like domain 1	1943					protein modification process|transport	cytosol|Golgi apparatus|membrane	acid-amino acid ligase activity|ARF guanyl-nucleotide exchange factor activity			ovary(6)|breast(6)|lung(5)|central_nervous_system(2)	19						ACATGTACCTGAAGAACATTT	0.358		NaN											0	0	0	0.007413	0	18	88									
RASL12	51285	broad.mit.edu	37	15	65347506	65347506	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr15:65347506C>T	uc002aoi.1	-	5	747	c.532G>A	c.(532-534)GAG>AAG	p.E178K	RASL12_uc002aoj.1_Missense_Mutation_p.E159K|RASL12_uc010uir.1_Missense_Mutation_p.E167K	NM_016563	NP_057647	Q9NYN1	RASLC_HUMAN	RAS-like, family 12 protein	178					small GTPase mediated signal transduction	membrane	GTP binding|GTPase activity			skin(1)	1						CGCACTGCCTCGTGGAAGACA	0.647		NaN											0	0	0	0.004482	0	7	29									
FEM1B	10116	broad.mit.edu	37	15	68582398	68582398	+	Silent	SNP	C	C	T	rs142803256		TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr15:68582398C>T	uc002arg.2	+	2	1317	c.702C>T	c.(700-702)GTC>GTT	p.V234V	FEM1B_uc002arh.2_Silent_p.V154V	NM_015322	NP_056137	Q9UK73	FEM1B_HUMAN	fem-1 homolog b	234	ANK 6.				apoptosis|induction of apoptosis|regulation of DNA damage checkpoint|regulation of ubiquitin-protein ligase activity	cytoplasm|nucleus	death receptor binding|ubiquitin-protein ligase activity				0						AAGCTGATGTCGTAGAACTGT	0.458		NaN											0	0	0	0.003755	0	36	466									
ITGA11	22801	broad.mit.edu	37	15	68600001	68600001	+	Missense_Mutation	SNP	A	A	G			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr15:68600001A>G	uc002ari.2	-	27	3295	c.3208T>C	c.(3208-3210)TGC>CGC	p.C1070R	ITGA11_uc010bib.2_Missense_Mutation_p.C1071R	NM_001004439	NP_001004439	Q9UKX5	ITA11_HUMAN	integrin, alpha 11 precursor	1070	Extracellular (Potential).				cell-matrix adhesion|integrin-mediated signaling pathway|muscle organ development	integrin complex	collagen binding|receptor activity			kidney(2)|pancreas(1)	3					Tirofiban(DB00775)	CGTATATTGCAGTTGATGGAG	0.542		NaN											0	0	0	0.01441	0	62	22									
THAP10	56906	broad.mit.edu	37	15	71174897	71174897	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr15:71174897C>T	uc002asv.2	-	3	812	c.670G>A	c.(670-672)GAC>AAC	p.D224N	LRRC49_uc002asu.2_Intron	NM_020147	NP_064532	Q9P2Z0	THA10_HUMAN	THAP domain containing 10	224							DNA binding|metal ion binding			ovary(1)|skin(1)	2						GAGTAAATGTCAAAGAGAGAG	0.393		NaN											0	0	0	0.013726	0	34	187									
PML	5371	broad.mit.edu	37	15	74336969	74336969	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr15:74336969C>T	uc002awv.2	+	9	2409	c.2269C>T	c.(2269-2271)CTC>TTC	p.L757F	PML_uc002awu.2_Missense_Mutation_p.L709F|PML_uc010ule.1_Missense_Mutation_p.L318F	NM_033238	NP_150241	P29590	PML_HUMAN	promyelocytic leukemia protein isoform 1	757					cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction resulting in induction of apoptosis|endoplasmic reticulum calcium ion homeostasis|induction of apoptosis|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|maintenance of protein location in nucleus|negative regulation of angiogenesis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of mitotic cell cycle|negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|negative regulation of telomerase activity|negative regulation of telomere maintenance via telomerase|negative regulation of transcription, DNA-dependent|negative regulation of translation in response to oxidative stress|PML body organization|PML body organization|positive regulation of defense response to virus by host|positive regulation of histone deacetylation|protein complex assembly|protein stabilization|protein targeting|regulation of calcium ion transport into cytosol|regulation of protein phosphorylation|response to hypoxia|response to virus|transcription, DNA-dependent	cytoplasm|cytosol|early endosome membrane|extrinsic to endoplasmic reticulum membrane|insoluble fraction|nuclear matrix|nuclear membrane|nucleolus|nucleus|PML body	cobalt ion binding|DNA binding|protein binding|protein binding|protein heterodimerization activity|protein homodimerization activity|SUMO binding|transcription coactivator activity|ubiquitin protein ligase binding|zinc ion binding|zinc ion binding			central_nervous_system(2)|kidney(2)|breast(1)	5						GTGCCGCCTCCTCGAGGTCTC	0.652		NaN	T	RARA|PAX5	APL|ALL								0	0	0	0.000602	0	4	23									
FANCI	55215	broad.mit.edu	37	15	89834895	89834895	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr15:89834895G>C	uc010bnp.1	+	20	2032	c.1942G>C	c.(1942-1944)GAA>CAA	p.E648Q	FANCI_uc002bnm.1_Missense_Mutation_p.E648Q|FANCI_uc002bnn.1_RNA|FANCI_uc002bnp.1_Missense_Mutation_p.E469Q|FANCI_uc002bnq.1_Missense_Mutation_p.E61Q	NM_001113378	NP_001106849	Q9NVI1	FANCI_HUMAN	Fanconi anemia, complementation group I isoform	648					cell cycle|DNA repair	nucleoplasm	protein binding			ovary(2)	2	Lung NSC(78;0.0472)|all_lung(78;0.089)					TCTGAAATTAGAAGCTTGTAT	0.353		NaN						Direct_reversal_of_damage|Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				0	0	0	0.00874	0	38	161									
C15orf42	90381	broad.mit.edu	37	15	90161397	90161397	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr15:90161397G>C	uc002boe.2	+	17	2975	c.2975G>C	c.(2974-2976)GGT>GCT	p.G992A		NM_152259	NP_689472	Q7Z2Z1	TICRR_HUMAN	leucine-rich repeat kinase 1	992					cell cycle|DNA repair|DNA replication|formation of translation preinitiation complex|G2/M transition checkpoint|mitotic cell cycle DNA replication checkpoint|regulation of DNA-dependent DNA replication initiation|response to ionizing radiation	nucleus	chromatin binding|protein binding			ovary(4)|central_nervous_system(2)|skin(1)	7	Lung NSC(78;0.0237)|all_lung(78;0.0478)		BRCA - Breast invasive adenocarcinoma(143;0.128)			TCTGATCCTGGTCCTGATATT	0.413		NaN											0	0	0	0.01441	0	157	269									
AP3S2	10239	broad.mit.edu	37	15	90431850	90431850	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr15:90431850G>A	uc002boq.3	-	3	612	c.176C>T	c.(175-177)TCT>TTT	p.S59F	AP3S2_uc002bos.3_Missense_Mutation_p.S260F|AP3S2_uc010bns.2_RNA|AP3S2_uc002bor.3_RNA|AP3S2_uc010bnt.2_Intron	NM_005829	NP_005820	P59780	AP3S2_HUMAN	adaptor-related protein complex 3, sigma 2	59					intracellular protein transport|vesicle-mediated transport	cytoplasmic vesicle membrane|Golgi apparatus|membrane coat	protein transporter activity				0	Lung NSC(78;0.0181)|all_lung(78;0.0384)		BRCA - Breast invasive adenocarcinoma(143;0.0107)|KIRC - Kidney renal clear cell carcinoma(17;0.0286)|Kidney(142;0.0514)|STAD - Stomach adenocarcinoma(125;0.223)			TTTGTAGTCAGAGCCACCAAT	0.418		NaN											0	0	0	0.009096	0	3	35									
CHD2	1106	broad.mit.edu	37	15	93558043	93558043	+	Nonsense_Mutation	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr15:93558043C>T	uc002bsp.2	+	37	5385	c.4810C>T	c.(4810-4812)CAG>TAG	p.Q1604*	CHD2_uc002bso.1_Nonsense_Mutation_p.Q1604*	NM_001271	NP_001262	O14647	CHD2_HUMAN	chromodomain helicase DNA binding protein 2	1604					regulation of transcription from RNA polymerase II promoter	nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding			ovary(1)|skin(1)	2	Lung NSC(78;0.00976)|all_lung(78;0.016)		BRCA - Breast invasive adenocarcinoma(143;0.0282)|OV - Ovarian serous cystadenocarcinoma(32;0.0814)			CCTTCACCCTCAGAAGCCTCA	0.532		NaN											0	0	0	0.00333	0	22	170									
CHD2	1106	broad.mit.edu	37	15	93558052	93558052	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr15:93558052C>T	uc002bsp.2	+	37	5394	c.4819C>T	c.(4819-4821)CAT>TAT	p.H1607Y	CHD2_uc002bso.1_Missense_Mutation_p.H1607Y	NM_001271	NP_001262	O14647	CHD2_HUMAN	chromodomain helicase DNA binding protein 2	1607					regulation of transcription from RNA polymerase II promoter	nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding			ovary(1)|skin(1)	2	Lung NSC(78;0.00976)|all_lung(78;0.016)		BRCA - Breast invasive adenocarcinoma(143;0.0282)|OV - Ovarian serous cystadenocarcinoma(32;0.0814)			TCAGAAGCCTCATTTGCCTGC	0.517		NaN											0	0	0	0.005443	0	25	174									
AXIN1	8312	broad.mit.edu	37	16	339566	339566	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr16:339566G>A	uc002cgp.1	-	10	2513	c.2336C>T	c.(2335-2337)CCG>CTG	p.P779L	AXIN1_uc002cgq.1_Missense_Mutation_p.P743L	NM_003502	NP_003493	O15169	AXIN1_HUMAN	axin 1 isoform a	779	Interaction with PPP2CA.				activation of JUN kinase activity|activation of protein kinase activity|apoptosis|axial mesoderm formation|canonical Wnt receptor signaling pathway involved in neural plate anterior/posterior pattern formation|cellular protein complex assembly|cellular response to organic cyclic compound|cytoplasmic microtubule organization|determination of left/right symmetry|dorsal/ventral axis specification|embryonic eye morphogenesis|embryonic skeletal joint morphogenesis|forebrain anterior/posterior pattern formation|muscle cell development|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of fat cell differentiation|olfactory placode formation|optic placode formation|positive regulation of JNK cascade|positive regulation of peptidyl-serine phosphorylation|positive regulation of peptidyl-threonine phosphorylation|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of transcription, DNA-dependent|positive regulation of ubiquitin-protein ligase activity|regulation of catenin import into nucleus|tail morphogenesis|Wnt receptor signaling pathway involved in forebrain neuron fate commitment|Wnt receptor signaling pathway involved in somitogenesis	APC-Axin-1-beta-catenin complex|Axin-APC-beta-catenin-GSK3B complex|beta-catenin destruction complex|cell cortex|cytoplasmic membrane-bounded vesicle|cytoplasmic microtubule|cytosol|lateral plasma membrane|nucleus|perinuclear region of cytoplasm|postsynaptic density	armadillo repeat domain binding|beta-catenin binding|GTPase activator activity|I-SMAD binding|p53 binding|protein complex scaffold|protein homodimerization activity|protein kinase binding|signal transducer activity|ubiquitin protein ligase binding			breast(1)|liver(1)	2		all_cancers(16;2.75e-07)|all_epithelial(16;1.6e-06)|Hepatocellular(16;0.000105)|Lung NSC(18;0.00774)|all_lung(18;0.0187)				GCTGTCACACGGCTGGGCACT	0.637		NaN											0	0	0	0.001168	0	6	34									
MAPK8IP3	23162	broad.mit.edu	37	16	1797074	1797074	+	Silent	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr16:1797074C>T	uc002cmk.2	+	6	909	c.789C>T	c.(787-789)GCC>GCT	p.A263A	MAPK8IP3_uc002cmj.1_RNA|MAPK8IP3_uc002cml.2_Silent_p.A263A|MAPK8IP3_uc010uvl.1_Silent_p.A264A	NM_015133	NP_055948	Q9UPT6	JIP3_HUMAN	mitogen-activated protein kinase 8 interacting	263					vesicle-mediated transport	Golgi membrane	kinesin binding|MAP-kinase scaffold activity|protein kinase binding			breast(2)|central_nervous_system(1)	3						CCTCGGCGGCCGCCACACCCA	0.667		NaN											0	0	0	0.000602	0	3	21									
OR2C1	4993	broad.mit.edu	37	16	3406140	3406140	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr16:3406140C>G	uc002cuw.1	+	1	252	c.200C>G	c.(199-201)TCC>TGC	p.S67C		NM_012368	NP_036500	O95371	OR2C1_HUMAN	olfactory receptor, family 2, subfamily C,	67	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						AGCAACCTCTCCTCCTTGGAC	0.522		NaN											0	0	0	0.006999	0	37	161									
CREBBP	1387	broad.mit.edu	37	16	3807965	3807965	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr16:3807965G>A	uc002cvv.2	-	18	3658	c.3454C>T	c.(3454-3456)CAG>TAG	p.Q1152*	CREBBP_uc002cvw.2_Nonsense_Mutation_p.Q1114*	NM_004380	NP_004371	Q92793	CBP_HUMAN	CREB binding protein isoform a	1152	Bromo.				cellular lipid metabolic process|homeostatic process|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|protein complex assembly|response to hypoxia	cytoplasm|nuclear body	histone acetyltransferase activity|MyoD binding|p53 binding|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription coactivator activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(97)|ovary(14)|lung(6)|skin(6)|breast(2)|NS(1)|pancreas(1)	127		Ovarian(90;0.0266)		OV - Ovarian serous cystadenocarcinoma(1;3.54e-05)		TCCACGTACTGCCAGGGCTCT	0.458		NaN	T|N|F|Mis|O	MLL|MORF|RUNXBP2	ALL|AML|DLBCL|B-NHL 		Rubinstein-Taybi syndrome		Rubinstein-Taybi_syndrome				0	0	0	0.004007	0	16	65									
ITPRIPL2	162073	broad.mit.edu	37	16	19126049	19126049	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr16:19126049C>T	uc002dfu.3	+	1	796	c.266C>T	c.(265-267)TCG>TTG	p.S89L	ITPRIPL2_uc002dft.2_5'UTR	NM_001034841	NP_001030013	Q3MIP1	IPIL2_HUMAN	inositol 1,4,5-triphosphate receptor interacting	89	Cytoplasmic (Potential).					integral to membrane				skin(2)	2						GCCTTCTCCTCGAGACACTTC	0.662		NaN											0	0	0	0.001168	0	5	14									
TAOK2	9344	broad.mit.edu	37	16	29998037	29998037	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr16:29998037G>A	uc002dva.1	+	16	3227	c.2444G>A	c.(2443-2445)AGG>AAG	p.R815K	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|TAOK2_uc002dvb.1_Intron|TAOK2_uc002dvc.1_Intron|TAOK2_uc010bzm.1_Missense_Mutation_p.R822K|TAOK2_uc002dvd.1_Missense_Mutation_p.R642K	NM_016151	NP_057235	Q9UL54	TAOK2_HUMAN	TAO kinase 2 isoform 2	815	Glu-rich.				actin cytoskeleton organization|activation of MAPKK activity|apoptosis|cell migration|focal adhesion assembly|positive regulation of JNK cascade|protein targeting to membrane|regulation of cell growth|regulation of cell shape|response to stress	cytoplasmic vesicle membrane|cytoskeleton|dendrite|integral to membrane|nucleolus	ATP binding|protein serine/threonine kinase activity			ovary(1)	1						AAGCAGCAGAGGATTCTGGGG	0.552		NaN											0	0	0	0.008291	0	10	76									
ZNF689	115509	broad.mit.edu	37	16	30620909	30620909	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr16:30620909C>T	uc002dyx.2	-	2	576	c.256G>A	c.(256-258)GAT>AAT	p.D86N	ZNF689_uc010bzy.2_5'UTR	NM_138447	NP_612456	Q96CS4	ZN689_HUMAN	zinc finger protein HIT-39	86	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0			Colorectal(24;0.198)			TCCCAGTCATCGGTGTTTCGT	0.567		NaN											0	0	0	0.008291	0	9	53									
SRCAP	10847	broad.mit.edu	37	16	30735080	30735080	+	Silent	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr16:30735080C>T	uc002dze.1	+	25	4720	c.4335C>T	c.(4333-4335)ACC>ACT	p.T1445T	SRCAP_uc002dzf.2_RNA|SRCAP_uc002dzg.1_Silent_p.T1240T|SRCAP_uc010bzz.1_Silent_p.T1015T	NM_006662	NP_006653	Q6ZRS2	SRCAP_HUMAN	Snf2-related CBP activator protein	1445	Pro-rich.				interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|nucleus|protein complex	ATP binding|DNA binding|helicase activity|histone acetyltransferase activity|transcription coactivator activity			ovary(3)|skin(1)	4			Colorectal(24;0.198)			CTGTCCCCACCACACTTCCTG	0.567		NaN											0	0	0	0.009535	0	32	118									
ABCC12	94160	broad.mit.edu	37	16	48177901	48177901	+	Silent	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr16:48177901C>T	uc002efc.1	-	2	541	c.195G>A	c.(193-195)GTG>GTA	p.V65V	ABCC12_uc002eey.1_RNA|ABCC12_uc002eez.1_RNA|ABCC12_uc002efa.1_RNA|ABCC12_uc002efb.1_RNA|ABCC12_uc002efd.1_RNA|ABCC12_uc002efe.1_Silent_p.V65V|ABCC12_uc010vgj.1_RNA	NM_033226	NP_150229	Q96J65	MRP9_HUMAN	ATP-binding cassette protein C12	65						integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(2)|skin(1)	3		all_cancers(37;0.0474)|all_lung(18;0.047)				GGTAGCCTTTCACCATCACCG	0.552		NaN											0	0	0	0.010729	0	12	163									
ADCY7	113	broad.mit.edu	37	16	50339495	50339495	+	Silent	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr16:50339495G>A	uc002egd.1	+	12	1945	c.1677G>A	c.(1675-1677)ACG>ACA	p.T559T	ADCY7_uc002egc.1_Silent_p.T559T	NM_001114	NP_001105	P51828	ADCY7_HUMAN	adenylate cyclase 7	559	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to ethanol|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|positive regulation of cAMP biosynthetic process|synaptic transmission|transmembrane transport|water transport	integral to membrane|plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding			skin(1)	1		all_cancers(37;0.0127)		GBM - Glioblastoma multiforme(240;0.195)	Bromocriptine(DB01200)	TCAGCTCCACGAGGTGAGGTC	0.612		NaN											0	0	0	0.01441	0	53	88									
ADCY7	113	broad.mit.edu	37	16	50339739	50339739	+	Silent	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr16:50339739G>A	uc002egd.1	+	13	1999	c.1731G>A	c.(1729-1731)CTG>CTA	p.L577L	ADCY7_uc002egc.1_Silent_p.L577L	NM_001114	NP_001105	P51828	ADCY7_HUMAN	adenylate cyclase 7	577	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to ethanol|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|positive regulation of cAMP biosynthetic process|synaptic transmission|transmembrane transport|water transport	integral to membrane|plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding			skin(1)	1		all_cancers(37;0.0127)		GBM - Glioblastoma multiforme(240;0.195)	Bromocriptine(DB01200)	CCATCTTCCTGGAGAAGGGCT	0.672		NaN											0	0	0	0.010818	0	30	44									
BRD7	29117	broad.mit.edu	37	16	50383964	50383964	+	Silent	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr16:50383964G>A	uc002egf.1	-	6	628	c.561C>T	c.(559-561)AAC>AAT	p.N187N	BRD7_uc002ege.1_Silent_p.N187N	NM_013263	NP_037395	Q9NPI1	BRD7_HUMAN	bromodomain containing 7	187	Bromo.				cell cycle|negative regulation of cell proliferation|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of transcription, DNA-dependent|positive regulation of histone acetylation|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent|Wnt receptor signaling pathway	cytoplasm|nucleus	histone acetyl-lysine binding|p53 binding|transcription coactivator activity|transcription corepressor activity|transcription factor binding|transcription regulatory region DNA binding				0		all_cancers(37;0.0127)				GATAGTCATTGTTCTTGATCT	0.343		NaN											0	0	0	0.01441	0	86	121									
PRSS54	221191	broad.mit.edu	37	16	58314274	58314274	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr16:58314274C>T	uc002enf.2	-	7	1437	c.1042G>A	c.(1042-1044)GAG>AAG	p.E348K	PRSS54_uc002eng.2_Missense_Mutation_p.E348K|PRSS54_uc010vie.1_Missense_Mutation_p.E249K|CCDC113_uc002ene.2_3'UTR|CCDC113_uc010vid.1_3'UTR	NM_001080492	NP_001073961	Q6PEW0	PRS54_HUMAN	plasma kallikrein-like protein 4 precursor	348					proteolysis	extracellular region	serine-type endopeptidase activity			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	3						ACAGACGCCTCAGGAGACCTG	0.478		NaN											0	0	0	0.012319	0	22	63									
RRAD	6236	broad.mit.edu	37	16	66957559	66957559	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr16:66957559G>A	uc002eqn.2	-	4	661	c.509C>T	c.(508-510)TCA>TTA	p.S170L	RRAD_uc002eqo.2_Missense_Mutation_p.S170L	NM_001128850	NP_001122322	P55042	RAD_HUMAN	Ras-related associated with diabetes	170					small GTPase mediated signal transduction	plasma membrane	calmodulin binding|GTP binding|GTPase activity				0		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0862)|Epithelial(162;0.198)		GTCCGTCACTGAGTACACAAT	0.607		NaN											0	0	0	0.00278	0	22	69									
CES2	8824	broad.mit.edu	37	16	66976646	66976646	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr16:66976646G>A	uc002eqr.2	+	10	2570	c.1570G>A	c.(1570-1572)GAG>AAG	p.E524K	CES2_uc002eqq.2_Intron|CES2_uc002eqs.2_Missense_Mutation_p.E367K	NM_003869	NP_003860	O00748	EST2_HUMAN	carboxylesterase 2 isoform 1	460					catabolic process	endoplasmic reticulum lumen	carboxylesterase activity|methyl indole-3-acetate esterase activity|methyl jasmonate esterase activity|methyl salicylate esterase activity				0		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0663)|Epithelial(162;0.166)		CCATGGTGATGAGCTTCCTTT	0.552		NaN											0	0	0	0.010729	0	11	51									
RLTPR	146206	broad.mit.edu	37	16	67683380	67683380	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr16:67683380C>T	uc002etn.2	+	20	1897	c.1777C>T	c.(1777-1779)CGG>TGG	p.R593W	RLTPR_uc010cel.1_Missense_Mutation_p.R586W|RLTPR_uc010vjr.1_Missense_Mutation_p.R557W	NM_001013838	NP_001013860	Q6F5E8	LR16C_HUMAN	RGD motif, leucine rich repeats, tropomodulin	593	Tropomodulin-like.|LRR 13.									breast(1)	1		Acute lymphoblastic leukemia(13;3.23e-05)|all_hematologic(13;0.00251)|Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0146)|Epithelial(162;0.0481)|all cancers(182;0.232)		GGCTGAGTCTCGGCTGAAGCT	0.632		NaN											0	0	0	0.00308	0	6	26									
TSNAXIP1	55815	broad.mit.edu	37	16	67859121	67859121	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr16:67859121G>A	uc002euj.2	+	7	992	c.598G>A	c.(598-600)GAC>AAC	p.D200N	TSNAXIP1_uc010cep.2_Missense_Mutation_p.D64N|TSNAXIP1_uc010vjz.1_Missense_Mutation_p.D77N|TSNAXIP1_uc002euf.3_5'UTR|TSNAXIP1_uc010vka.1_Missense_Mutation_p.D254N|TSNAXIP1_uc010vkb.1_Missense_Mutation_p.D185N|TSNAXIP1_uc002eug.3_5'UTR|TSNAXIP1_uc002euh.3_5'UTR|TSNAXIP1_uc002eui.3_5'UTR|TSNAXIP1_uc002euk.2_5'UTR	NM_018430	NP_060900	Q2TAA8	TXIP1_HUMAN	translin-associated factor X interacting protein	200					cell differentiation|multicellular organismal development|spermatogenesis	perinuclear region of cytoplasm					0		Acute lymphoblastic leukemia(13;3.76e-06)|all_hematologic(13;0.000303)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.00432)|Epithelial(162;0.0192)|all cancers(182;0.125)		CCTCATCGCAGACCTGAATGA	0.542		NaN											0	0	0	0.00245	0	15	45									
SLC12A4	6560	broad.mit.edu	37	16	67985184	67985184	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr16:67985184C>T	uc002euz.2	-	9	1297	c.1156G>A	c.(1156-1158)GAG>AAG	p.E386K	SLC12A4_uc010ceu.2_Missense_Mutation_p.E380K|SLC12A4_uc010vkh.1_Missense_Mutation_p.E355K|SLC12A4_uc010vki.1_Missense_Mutation_p.E386K|SLC12A4_uc010vkj.1_Missense_Mutation_p.E388K|SLC12A4_uc002eva.2_Missense_Mutation_p.E386K|SLC12A4_uc002evb.2_RNA	NM_005072	NP_005063	Q9UP95	S12A4_HUMAN	solute carrier family 12, member 4 isoform a	386	Cytoplasmic (Potential).				cell volume homeostasis|potassium ion transport|sodium ion transport	integral to plasma membrane|membrane fraction	potassium:chloride symporter activity			ovary(1)	1		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0042)|Epithelial(162;0.0185)|all cancers(182;0.121)	Bumetanide(DB00887)|Potassium Chloride(DB00761)	TCACCCTTCTCCAGGTAGGCG	0.632		NaN											0	0	0	0.014323	0	22	76									
HP	3240	broad.mit.edu	37	16	72094456	72094456	+	Silent	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr16:72094456G>A	uc002fbr.3	+	7	932	c.888G>A	c.(886-888)CTG>CTA	p.L296L	TXNL4B_uc010cgl.2_Intron|HP_uc010cgm.2_Silent_p.L237L|HP_uc002fbt.3_Silent_p.L237L|HP_uc002fbu.1_Silent_p.L34L|HP_uc002fbv.3_Silent_p.L207L|HP_uc002fbw.3_Silent_p.L118L|HP_uc002fbx.3_Silent_p.L118L|HPR_uc002fby.2_5'Flank	NM_005143	NP_005134	P00738	HPT_HUMAN	haptoglobin isoform 1 preproprotein	296	Peptidase S1.				cellular iron ion homeostasis|defense response|negative regulation of hydrogen peroxide catabolic process|negative regulation of oxidoreductase activity|positive regulation of cell death|proteolysis|response to hydrogen peroxide	extracellular region|haptoglobin-hemoglobin complex	hemoglobin binding|serine-type endopeptidase activity				0		Renal(780;9.67e-05)|Ovarian(137;0.00327)|Hepatocellular(780;0.114)		BRCA - Breast invasive adenocarcinoma(221;0.00015)|Kidney(780;0.000529)		CTGACCATCTGAAGTATGTCA	0.493		NaN											0	0	0	0.00245	0	15	36									
HPR	3250	broad.mit.edu	37	16	72108235	72108235	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr16:72108235G>C	uc002fby.2	+	3	174	c.144G>C	c.(142-144)TTG>TTC	p.L48F	TXNL4B_uc010cgl.2_Intron	NM_020995	NP_066275	P00739	HPTR_HUMAN	haptoglobin-related protein precursor	48	Sushi.				proteolysis	spherical high-density lipoprotein particle	hemoglobin binding|serine-type endopeptidase activity			central_nervous_system(1)	1		Ovarian(137;0.125)				TGGAGCACTTGTTTCGCTACC	0.493		NaN											0	0	0	0.013537	0	13	63									
ADAMTS18	170692	broad.mit.edu	37	16	77325188	77325188	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr16:77325188C>A	uc002ffc.3	-	21	3796	c.3377G>T	c.(3376-3378)GGA>GTA	p.G1126V		NM_199355	NP_955387	Q8TE60	ATS18_HUMAN	ADAM metallopeptidase with thrombospondin type 1	1126	TSP type-1 5.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			large_intestine(4)|lung(4)|kidney(4)|skin(3)|breast(1)|ovary(1)|pancreas(1)	18						TGAATACCATCCAGCTACCAT	0.502		NaN											1	0	0.00198382	0.001984	0.0020089	5	77									
ATP2C2	9914	broad.mit.edu	37	16	84473071	84473071	+	Silent	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr16:84473071C>T	uc002fhx.2	+	13	1239	c.1150C>T	c.(1150-1152)CTG>TTG	p.L384L	ATP2C2_uc010chj.2_Silent_p.L384L|ATP2C2_uc002fhy.2_Silent_p.L401L|ATP2C2_uc002fhz.2_Silent_p.L233L	NM_014861	NP_055676	O75185	AT2C2_HUMAN	ATPase, Ca++ transporting, type 2C, member 2	384	Extracellular (Potential).				ATP biosynthetic process	Golgi membrane|integral to membrane	ATP binding|calcium-transporting ATPase activity|metal ion binding|protein binding			breast(1)|central_nervous_system(1)	2						GACGGGGACTCTGACTGCCAA	0.502		NaN											0	0	0	0.01441	0	52	205									
ZCCHC14	23174	broad.mit.edu	37	16	87445991	87445991	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr16:87445991G>C	uc002fjz.1	-	12	1952	c.1925C>G	c.(1924-1926)TCG>TGG	p.S642W	ZCCHC14_uc002fka.1_RNA|ZCCHC14_uc002fkb.2_Missense_Mutation_p.S418W	NM_015144	NP_055959	Q8WYQ9	ZCH14_HUMAN	zinc finger, CCHC domain containing 14	642					cell communication		nucleic acid binding|phosphatidylinositol binding|zinc ion binding			upper_aerodigestive_tract(1)|breast(1)	2				BRCA - Breast invasive adenocarcinoma(80;0.0285)		AACAGATGACGACAGCAGCAG	0.592		NaN											0	0	0	0.005443	0	29	109									
ZCCHC14	23174	broad.mit.edu	37	16	87446150	87446150	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr16:87446150G>C	uc002fjz.1	-	12	1793	c.1766C>G	c.(1765-1767)TCC>TGC	p.S589C	ZCCHC14_uc002fka.1_RNA|ZCCHC14_uc002fkb.2_Missense_Mutation_p.S365C	NM_015144	NP_055959	Q8WYQ9	ZCH14_HUMAN	zinc finger, CCHC domain containing 14	589					cell communication		nucleic acid binding|phosphatidylinositol binding|zinc ion binding			upper_aerodigestive_tract(1)|breast(1)	2				BRCA - Breast invasive adenocarcinoma(80;0.0285)		GGGACCAAAGGAGACTGTGGG	0.657		NaN											0	0	0	0.00308	0	8	46									
MYO1C	4641	broad.mit.edu	37	17	1371362	1371362	+	Missense_Mutation	SNP	T	T	C			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr17:1371362T>C	uc002fsp.2	-	28	3036	c.2816A>G	c.(2815-2817)CAG>CGG	p.Q939R	MYO1C_uc002fsn.2_Missense_Mutation_p.Q920R|MYO1C_uc002fso.2_Missense_Mutation_p.Q904R|MYO1C_uc010vqj.1_Missense_Mutation_p.Q904R	NM_001080779	NP_001074248	O00159	MYO1C_HUMAN	myosin IC isoform a	939					mRNA transport|protein transport|transmembrane transport	basal plasma membrane|cytoplasm|filamentous actin|lateral plasma membrane|nuclear pore|nucleolus|nucleoplasm|stereocilium membrane	actin binding|ATP binding|calmodulin binding|motor activity				0				UCEC - Uterine corpus endometrioid carcinoma (25;0.0822)		GAGCAGCAGCTGCCGGGAGCG	0.627		NaN											0	0	0	0.008291	0	7	39									
PRPF8	10594	broad.mit.edu	37	17	1576684	1576684	+	Silent	SNP	G	G	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr17:1576684G>T	uc002fte.2	-	23	3738	c.3624C>A	c.(3622-3624)ACC>ACA	p.T1208T		NM_006445	NP_006436	Q6P2Q9	PRP8_HUMAN	U5 snRNP-specific protein	1208						catalytic step 2 spliceosome|nuclear speck|U5 snRNP	protein binding|RNA binding			lung(4)|ovary(2)	6				UCEC - Uterine corpus endometrioid carcinoma (25;0.0855)		CGTCCTTGTGGGTGAACTCCT	0.587		NaN											1	0	2.0095e-06	0.001984	2.05857e-06	7	36									
PRPF8	10594	broad.mit.edu	37	17	1576731	1576731	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr17:1576731C>T	uc002fte.2	-	23	3691	c.3577G>A	c.(3577-3579)GAG>AAG	p.E1193K		NM_006445	NP_006436	Q6P2Q9	PRP8_HUMAN	U5 snRNP-specific protein	1193						catalytic step 2 spliceosome|nuclear speck|U5 snRNP	protein binding|RNA binding			lung(4)|ovary(2)	6				UCEC - Uterine corpus endometrioid carcinoma (25;0.0855)		ATGCGGCACTCGAAGCCACAC	0.577		NaN											0	0	0	0.008871	0	19	61									
KIAA0664	23277	broad.mit.edu	37	17	2597243	2597243	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr17:2597243C>T	uc002fuy.1	-	19	3151	c.3065G>A	c.(3064-3066)TGC>TAC	p.C1022Y	KIAA0664_uc002fux.1_Missense_Mutation_p.C955Y|KIAA0664_uc010ckc.1_Missense_Mutation_p.C8Y	NM_015229	NP_056044	O75153	K0664_HUMAN	hypothetical protein LOC23277	1022	TPR 2.						binding			breast(2)	2						GAGGCGCAGGCAGGCGCAGGT	0.627		NaN											0	0	0	0.001984	0	6	10									
ATP2A3	489	broad.mit.edu	37	17	3856676	3856676	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr17:3856676C>T	uc002fxb.1	-	3	335	c.184G>A	c.(184-186)GTG>ATG	p.V62M	ATP2A3_uc002fwx.1_Missense_Mutation_p.V62M|ATP2A3_uc002fwy.1_Missense_Mutation_p.V62M|ATP2A3_uc002fwz.1_Missense_Mutation_p.V62M|ATP2A3_uc002fxa.1_Missense_Mutation_p.V62M|ATP2A3_uc002fxc.1_Missense_Mutation_p.V62M|ATP2A3_uc002fxd.1_Missense_Mutation_p.V62M	NM_174955	NP_777615	Q93084	AT2A3_HUMAN	ATPase, Ca++ transporting, ubiquitous isoform b	62	Helical; Name=1; (By similarity).				ATP biosynthetic process|platelet activation	integral to membrane|nuclear membrane|platelet dense tubular network membrane|sarcoplasmic reticulum membrane	ATP binding|calcium-transporting ATPase activity|metal ion binding|protein binding			ovary(3)|breast(1)|central_nervous_system(1)	5				LUAD - Lung adenocarcinoma(1115;0.000692)|Lung(3;0.0766)		AGGATGCGCACCAGGAGGTCC	0.647		NaN											0	0	0	0.00308	0	7	61									
ANKFY1	51479	broad.mit.edu	37	17	4086695	4086695	+	Silent	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr17:4086695G>A	uc002fxq.1	-	14	1988	c.1950C>T	c.(1948-1950)GTC>GTT	p.V650V	ANKFY1_uc002fxn.2_Silent_p.V692V|ANKFY1_uc002fxo.2_Silent_p.V650V|ANKFY1_uc002fxp.2_Silent_p.V649V|ANKFY1_uc010ckp.2_Silent_p.V591V	NM_016376	NP_057460	Q9P2R3	ANFY1_HUMAN	ankyrin repeat and FYVE domain containing 1	650	ANK 9.					endosome membrane	metal ion binding|protein binding			ovary(2)|skin(1)	3						CCTCCTACCTGACATTTATAT	0.488		NaN											0	0	0	0.00333	0	22	89									
GGT6	124975	broad.mit.edu	37	17	4462916	4462916	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr17:4462916G>A	uc002fyd.3	-	2	340	c.280C>T	c.(280-282)CCA>TCA	p.P94S	GGT6_uc010vsb.1_5'UTR|GGT6_uc002fyc.3_Missense_Mutation_p.P94S|GGT6_uc010vsc.1_Missense_Mutation_p.P94S	NM_001122890	NP_001116362	Q6P531	GGT6_HUMAN	gamma-glutamyltransferase 6 isoform a	94	Extracellular (Potential).				glutathione biosynthetic process	integral to membrane	acyltransferase activity|gamma-glutamyltransferase activity			skin(1)	1						CCGCCGGGTGGAGGGGCCACA	0.677		NaN											0	0	0	0.008291	0	11	16									
ZNF594	84622	broad.mit.edu	37	17	5086687	5086687	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr17:5086687G>A	uc010cla.1	-	2	1021	c.865C>T	c.(865-867)CAC>TAC	p.H289Y		NM_032530	NP_115919	Q96JF6	ZN594_HUMAN	zinc finger protein 594	289	C2H2-type 6.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|skin(1)	3						TCTCCAGTGTGAATTCTCTGA	0.433		NaN											0	0	0	0.012319	0	21	154									
NLRP1	22861	broad.mit.edu	37	17	5462822	5462822	+	Silent	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr17:5462822G>A	uc002gci.2	-	4	1749	c.1194C>T	c.(1192-1194)ATC>ATT	p.I398I	NLRP1_uc002gcg.1_Silent_p.I398I|NLRP1_uc002gck.2_Silent_p.I398I|NLRP1_uc002gcj.2_Silent_p.I398I|NLRP1_uc002gcl.2_Silent_p.I398I|NLRP1_uc002gch.3_Silent_p.I398I|NLRP1_uc010clh.2_Silent_p.I398I	NM_033004	NP_127497	Q9C000	NALP1_HUMAN	NLR family, pyrin domain containing 1 isoform 1	398	NACHT.				defense response to bacterium|induction of apoptosis|neuron apoptosis|positive regulation of interleukin-1 beta secretion|response to muramyl dipeptide	cytoplasm|NALP1 inflammasome complex|nucleus	ATP binding|caspase activator activity|enzyme binding|protein domain specific binding			lung(4)|breast(2)|ovary(1)|central_nervous_system(1)|skin(1)	9		Colorectal(1115;3.48e-05)				GCCTAGACAGGATCTGTCTAA	0.577		NaN											0	0	0	0.004482	0	6	38									
SLC13A5	284111	broad.mit.edu	37	17	6610016	6610016	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr17:6610016G>C	uc002gdj.2	-	3	401	c.313C>G	c.(313-315)CTG>GTG	p.L105V	SLC13A5_uc010vtf.1_Missense_Mutation_p.L105V|SLC13A5_uc010clq.2_Missense_Mutation_p.L62V|SLC13A5_uc002gdk.2_Missense_Mutation_p.L105V|SLC13A5_uc002gdl.1_5'Flank	NM_177550	NP_808218	Q86YT5	S13A5_HUMAN	solute carrier family 13, member 5 isoform a	105						integral to membrane	citrate transmembrane transporter activity				0						CTCTTGTGCAGGTTCCAGCGC	0.627		NaN											0	0	0	0.009096	0	3	26									
BCL6B	255877	broad.mit.edu	37	17	6930283	6930283	+	Silent	SNP	G	G	C			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr17:6930283G>C	uc002geg.2	+	8	1257	c.1200G>C	c.(1198-1200)CGG>CGC	p.R400R	BCL6B_uc010clt.1_Silent_p.R401R	NM_181844	NP_862827	Q8N143	BCL6B_HUMAN	B-cell CLL/lymphoma 6, member B (zinc finger	400	C2H2-type 3.					nucleus	zinc ion binding			skin(1)	1						CACATCTGCGGGCGCACGTGC	0.632		NaN											0	0	0	0.008291	0	11	56									
C17orf81	23587	broad.mit.edu	37	17	7160258	7160258	+	Silent	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr17:7160258C>T	uc002gfg.1	+	6	647	c.540C>T	c.(538-540)CTC>CTT	p.L180L	C17orf81_uc002gfj.2_Silent_p.L180L|C17orf81_uc010cmb.2_Silent_p.L180L|C17orf81_uc002gfh.1_Silent_p.L180L|C17orf81_uc002gfi.1_Silent_p.L180L|C17orf81_uc002gfl.1_Silent_p.L180L	NM_203415	NP_981960	Q8TE02	DERP6_HUMAN	S-phase 2 protein isoform 4	180					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	protein binding				0						TGGGAGCTCTCAGCAGCCTTG	0.617		NaN											0	0	0	0.00245	0	13	29									
GPS2	2874	broad.mit.edu	37	17	7217447	7217447	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr17:7217447G>A	uc002gfv.1	-	4	612	c.349C>T	c.(349-351)CAG>TAG	p.Q117*	GPS2_uc002gfw.1_Nonsense_Mutation_p.Q79*|GPS2_uc002gfx.1_Nonsense_Mutation_p.Q117*|NEURL4_uc002gfy.1_RNA|GPS2_uc002gfz.1_Nonsense_Mutation_p.Q117*	NM_004489	NP_004480	Q13227	GPS2_HUMAN	G protein pathway suppressor 2	117					cell cycle|inactivation of MAPK activity|JNK cascade|negative regulation of JNK cascade|negative regulation of transcription from RNA polymerase II promoter	transcriptional repressor complex	GTPase inhibitor activity|protein binding|transcription corepressor activity			ovary(2)|pancreas(1)	3		Prostate(122;0.157)				AGGCTCTGCTGGTATGCAGCT	0.507		NaN											0	0	0	0.010818	0	31	148									
ACAP1	9744	broad.mit.edu	37	17	7250445	7250445	+	Silent	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr17:7250445C>T	uc002ggd.2	+	14	1433	c.1227C>T	c.(1225-1227)GCC>GCT	p.A409A		NM_014716	NP_055531	Q15027	ACAP1_HUMAN	centaurin beta1	409	Arf-GAP.|Required for interaction with GULP1.				intracellular signal transduction|lipid metabolic process|protein transport|regulation of ARF GTPase activity		ARF GTPase activator activity|phospholipase C activity|protein binding|zinc ion binding			breast(2)|large_intestine(1)	3						ACGTGGTGGCCCAGGTCCAGA	0.667		NaN											0	0	0	0.006214	0	9	48									
TP53	7157	broad.mit.edu	37	17	7577556	7577556	+	Missense_Mutation	SNP	C	C	A	rs121912655		TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08			C	A	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr17:7577556C>A	uc002gim.2	-	7	919	c.725G>T	c.(724-726)TGC>TTC	p.C242F	TP53_uc002gig.1_Missense_Mutation_p.C242F|TP53_uc002gih.2_Missense_Mutation_p.C242F|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.C110F|TP53_uc010cng.1_Missense_Mutation_p.C110F|TP53_uc002gii.1_Missense_Mutation_p.C110F|TP53_uc010cnh.1_Missense_Mutation_p.C242F|TP53_uc010cni.1_Missense_Mutation_p.C242F|TP53_uc002gij.2_Missense_Mutation_p.C242F|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.C149F|TP53_uc002gio.2_Missense_Mutation_p.C110F	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	242	|Interaction with HIPK1 (By similarity).|Interacts with the 53BP2 SH3 domain.|Interaction with AXIN1 (By similarity).	Zinc.	C -> F (in sporadic cancers; somatic mutation).|C -> G (in sporadic cancers; somatic mutation).|C -> S (in sporadic cancers; somatic mutation).|C -> R (in sporadic cancers; somatic mutation).|C -> W (in sporadic cancers; somatic mutation).|C -> Y (in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.C242F(63)|p.C242Y(37)|p.C242S(25)|p.C242fs*5(16)|p.C242R(11)|p.C242W(7)|p.0?(7)|p.N239_C242delNSSC(3)|p.C242*(3)|p.C242C(2)|p.C242G(2)|p.C242fs*20(1)|p.C242fs*23(1)|p.Y236_M243delYMCNSSCM(1)|p.C242_M246>L(1)|p.N239fs*4(1)|p.C238_M246delCNSSCMGGM(1)|p.S241_C242insX(1)|p.C238fs*21(1)|p.C242fs*98(1)|p.H233_C242del10(1)|p.N239_C242>S(1)|p.S241_G245delSCMGG(1)|p.N239_C242del(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GCCGCCCATGCAGGAACTGTT	0.577		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			1	0	0.000274275	0.004482	0.000279026	8	39									
TP53	7157	broad.mit.edu	37	17	7578275	7578275	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr17:7578275G>A	uc002gim.2	-	6	768	c.574C>T	c.(574-576)CAG>TAG	p.Q192*	TP53_uc002gig.1_Nonsense_Mutation_p.Q192*|TP53_uc002gih.2_Nonsense_Mutation_p.Q192*|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Nonsense_Mutation_p.Q60*|TP53_uc010cng.1_Nonsense_Mutation_p.Q60*|TP53_uc002gii.1_Nonsense_Mutation_p.Q60*|TP53_uc010cnh.1_Nonsense_Mutation_p.Q192*|TP53_uc010cni.1_Nonsense_Mutation_p.Q192*|TP53_uc002gij.2_Nonsense_Mutation_p.Q192*|TP53_uc010cnj.1_Intron|TP53_uc002gin.2_Nonsense_Mutation_p.Q99*|TP53_uc002gio.2_Nonsense_Mutation_p.Q60*|TP53_uc010vug.1_Nonsense_Mutation_p.Q153*	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	192	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		Q -> P (in sporadic cancers; somatic mutation).|Q -> H (in sporadic cancers; somatic mutation).|Q -> R (in sporadic cancers; somatic mutation).|QH -> HN (in a sporadic cancer; somatic mutation).|QH -> HY (in a sporadic cancer; somatic mutation).|Q -> L (in sporadic cancers; somatic mutation).|Q -> K (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.Q192*(64)|p.0?(7)|p.Q192R(5)|p.A189_V197delAPPQHLIRV(4)|p.Q192H(3)|p.P191fs*53(2)|p.G187fs*16(2)|p.Q192Q(2)|p.P191del(2)|p.K164_P219del(1)|p.P191fs*6(1)|p.A189_Q192>E(1)|p.P191fs*15(1)|p.P191_Q192delPQ(1)|p.Q192>XXXXXXXXX(1)|p.Q192K(1)|p.A189fs*53(1)|p.Q192fs*56(1)|p.Q192del(1)|p.Q192fs*16(1)|p.L188_P191del(1)|p.Q192fs*30(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		ATAAGATGCTGAGGAGGGGCC	0.557		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			0	0	0	0.00278	0	23	33									
EFNB3	1949	broad.mit.edu	37	17	7612706	7612706	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr17:7612706G>A	uc002gis.2	+	5	1232	c.835G>A	c.(835-837)GGT>AGT	p.G279S		NM_001406	NP_001397	Q15768	EFNB3_HUMAN	ephrin-B3 precursor	279	Cytoplasmic (Potential).				cell-cell signaling|interspecies interaction between organisms	integral to plasma membrane	ephrin receptor binding|transmembrane-ephrin receptor activity			ovary(1)	1		all_cancers(10;1.14e-06)|Prostate(122;0.081)				GGGCCTGGGGGGTGGAGGTGG	0.697		NaN											0	0	0	0.00308	0	8	27									
PIK3R5	23533	broad.mit.edu	37	17	8791859	8791859	+	Silent	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr17:8791859G>A	uc002glt.2	-	10	1312	c.1245C>T	c.(1243-1245)CGC>CGT	p.R415R	PIK3R5_uc010vuz.1_Silent_p.R415R|PIK3R5_uc002glu.3_Silent_p.R29R|PIK3R5_uc010coa.1_3'UTR|PIK3R5_uc010cob.1_Silent_p.R29R	NM_014308	NP_055123	Q8WYR1	PI3R5_HUMAN	phosphoinositide-3-kinase, regulatory subunit 5	415					platelet activation	cytosol|membrane|nucleus				breast(2)|large_intestine(1)|central_nervous_system(1)|skin(1)	5						GCCCAGGCCTGCGGTGGCCTC	0.632		NaN											0	0	0	0.008291	0	10	9									
LRRC48	83450	broad.mit.edu	37	17	17891266	17891266	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr17:17891266G>A	uc010vxd.1	+	6	677	c.298G>A	c.(298-300)GAG>AAG	p.E100K	LRRC48_uc002gsa.2_Missense_Mutation_p.E100K|LRRC48_uc010vxc.1_Missense_Mutation_p.E100K|LRRC48_uc002gsb.2_Missense_Mutation_p.E100K	NM_001130090	NP_001123562	Q9H069	LRC48_HUMAN	leucine rich repeat containing 48 isoform a	100	LRR 3.					cytoplasm				pancreas(1)	1	all_neural(463;0.228)					CAACAACATTGAGACCATCGA	0.552		NaN											0	0	0	0.006214	0	9	43									
B9D1	27077	broad.mit.edu	37	17	19251136	19251136	+	Missense_Mutation	SNP	C	C	T	rs148240978		TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr17:19251136C>T	uc002gvk.3	-	4	466	c.302G>A	c.(301-303)CGA>CAA	p.R101Q	B9D1_uc010cqm.1_Missense_Mutation_p.E77K|B9D1_uc002gvl.3_Missense_Mutation_p.E77K|B9D1_uc010vyr.1_Missense_Mutation_p.E121K|B9D1_uc010vys.1_Missense_Mutation_p.E152K|B9D1_uc010cqn.1_Missense_Mutation_p.E152K	NM_015681	NP_056496	Q9UPM9	B9D1_HUMAN	B9 protein	101	B9.				cilium assembly	centrosome|microtubule basal body	protein binding				0	all_cancers(12;2.04e-05)|all_epithelial(12;0.000806)|Hepatocellular(7;0.00345)|Breast(13;0.143)					CCCATAGCCTCGAACCACATC	0.607		NaN											0	0	0	0.004482	0	8	35									
FOXN1	8456	broad.mit.edu	37	17	26856166	26856166	+	Nonsense_Mutation	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr17:26856166C>T	uc010crm.2	+	5	952	c.754C>T	c.(754-756)CAG>TAG	p.Q252*	FOXN1_uc002hbj.2_Nonsense_Mutation_p.Q252*	NM_003593	NP_003584	O15353	FOXN1_HUMAN	forkhead box N1	252					defense response|embryo development|epithelial cell proliferation|keratinocyte differentiation|organ morphogenesis|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|regulation of transcription from RNA polymerase II promoter|thymus development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			skin(1)	1	Lung NSC(42;0.00431)					CTCACACTATCAGTACCAGCG	0.567		NaN											0	0	0	0.00245	0	14	90									
NEK8	284086	broad.mit.edu	37	17	27068520	27068520	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr17:27068520G>A	uc002hcp.2	+	14	1981	c.1981G>A	c.(1981-1983)GAT>AAT	p.D661N	TRAF4_uc002hcq.1_5'Flank|TRAF4_uc002hcs.2_5'Flank	NM_178170	NP_835464	Q86SG6	NEK8_HUMAN	NIMA-related kinase 8	661	RCC1 5.					cytoplasm|primary cilium	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			stomach(2)|ovary(1)|pancreas(1)|liver(1)|skin(1)	6	Lung NSC(42;0.0158)					AGTGCAGTTGGATGAGACACA	0.567		NaN											0	0	0	0.00245	0	15	64									
TIAF1	9220	broad.mit.edu	37	17	27401192	27401192	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr17:27401192C>G	uc002hdv.1	-	1	1436	c.26G>C	c.(25-27)AGA>ACA	p.R9T	MYO18A_uc010wbc.1_3'UTR|MYO18A_uc002hds.2_3'UTR|MYO18A_uc010csa.1_3'UTR|MYO18A_uc002hdt.1_3'UTR|MYO18A_uc002hdu.1_3'UTR	NM_004740	NP_004731	O95411	TIAF1_HUMAN	TGFB1-induced anti-apoptotic factor 1	9					anti-apoptosis|apoptosis|I-kappaB kinase/NF-kappaB cascade	nucleus					0	Lung NSC(42;0.015)		Epithelial(11;1.19e-05)|all cancers(11;6.57e-05)|BRCA - Breast invasive adenocarcinoma(11;0.000153)|Colorectal(6;0.0102)|COAD - Colon adenocarcinoma(6;0.031)			GGACTGCTCTCTGAAGGGTGA	0.597		NaN											0	0	0	0.00308	0	7	45									
CORO6	84940	broad.mit.edu	37	17	27946710	27946710	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr17:27946710C>T	uc002hel.2	-	2	282	c.280G>A	c.(280-282)GAC>AAC	p.D94N	CORO6_uc002hem.2_5'Flank|CORO6_uc002hen.2_5'Flank	NM_032854	NP_116243	Q6QEF8	CORO6_HUMAN	coronin 6	94	WD 1.				actin cytoskeleton organization	actin cytoskeleton	actin filament binding				0						ATAACGTTGTCATTGTGTGGA	0.572		NaN											0	0	0	0.012319	0	23	141									
TBC1D29	26083	broad.mit.edu	37	17	28887196	28887196	+	Missense_Mutation	SNP	A	A	G			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr17:28887196A>G	uc002hfh.2	+	2	223	c.74A>G	c.(73-75)GAT>GGT	p.D25G	TBC1D29_uc002hfi.2_RNA|uc002hfj.1_5'Flank	NM_015594	NP_056409	Q9UFV1	TBC29_HUMAN	TBC1 domain family, member 29	25	Rab-GAP TBC; truncated.					intracellular	Rab GTPase activator activity				0		Myeloproliferative disorder(56;0.0255)				GTGCTGAATGATGGGGTAAGG	0.627		NaN											0	0	0	0.000602	0	5	11									
CCL15	6359	broad.mit.edu	37	17	34325917	34325917	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr17:34325917G>A	uc010wcu.1	-	2	690	c.121C>T	c.(121-123)CCA>TCA	p.P41S	CCL14-CCL15_uc010wcs.1_RNA|CCL14-CCL15_uc010wct.1_RNA	NM_032965	NP_116741	Q16663	CCL15_HUMAN	chemokine (C-C motif) ligand 15 precursor	41					cell-cell signaling|cellular calcium ion homeostasis|immune response	extracellular space	chemoattractant activity|chemokine activity|heparin binding|signal transducer activity			ovary(1)	1		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		AGAACTACTGGATTTTCCAGT	0.438		NaN											0	0	0	0.011902	0	41	70									
ERBB2	2064	broad.mit.edu	37	17	37868208	37868208	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr17:37868208C>T	uc002hso.2	+	8	1167	c.929C>T	c.(928-930)TCC>TTC	p.S310F	ERBB2_uc002hsm.2_Missense_Mutation_p.S280F|ERBB2_uc010cwa.2_Missense_Mutation_p.S295F|ERBB2_uc002hsp.2_Missense_Mutation_p.S113F|ERBB2_uc010cwb.2_Missense_Mutation_p.S310F|ERBB2_uc010wek.1_Missense_Mutation_p.S34F|ERBB2_uc002hsl.2_Missense_Mutation_p.S280F|ERBB2_uc002hsn.1_Missense_Mutation_p.S310F	NM_004448	NP_004439	P04626	ERBB2_HUMAN	erbB-2 isoform a	310	Extracellular (Potential).				cell proliferation|heart development|phosphatidylinositol 3-kinase cascade|phosphatidylinositol-mediated signaling|positive regulation of cell adhesion|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|protein autophosphorylation|regulation of angiogenesis|regulation of microtubule-based process|regulation of transcription, DNA-dependent|transcription, DNA-dependent|wound healing	integral to membrane|nucleus|perinuclear region of cytoplasm|receptor complex	ATP binding|DNA binding|epidermal growth factor receptor activity|ErbB-3 class receptor binding|identical protein binding|protein C-terminus binding|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.S310F(2)|p.S310Y(1)		lung(73)|central_nervous_system(16)|ovary(16)|stomach(14)|breast(9)|upper_aerodigestive_tract(5)|large_intestine(3)|liver(3)|endometrium(2)|skin(1)|pancreas(1)	143	all_cancers(6;1.06e-93)|all_epithelial(6;2.33e-113)|Breast(7;9.37e-100)|Lung NSC(9;9.76e-10)|all_lung(9;5.34e-09)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)	Ovarian(249;0.0547)|Colorectal(1115;0.234)	UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|Epithelial(3;9.42e-64)|all cancers(3;5.61e-57)|BRCA - Breast invasive adenocarcinoma(8;2.5e-45)|STAD - Stomach adenocarcinoma(3;9.03e-13)|Colorectal(5;6.23e-08)|COAD - Colon adenocarcinoma(5;8.58e-06)|Lung(15;0.00193)|LUAD - Lung adenocarcinoma(14;0.0664)|OV - Ovarian serous cystadenocarcinoma(8;0.0917)|LUSC - Lung squamous cell carcinoma(15;0.171)	UCEC - Uterine corpus endometrioid carcinoma (308;0.0767)	Lapatinib(DB01259)|Letrozole(DB01006)|Trastuzumab(DB00072)	GACGTGGGATCCTGCACCCTC	0.582		1	A|Mis|O		breast|ovarian|other tumour types|NSCLC|gastric					TCGA GBM(5;<1E-08)			0	0	0	0.01441	0	52	251									
KRT34	3885	broad.mit.edu	37	17	39538574	39538574	+	Silent	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr17:39538574C>T	uc002hwm.2	-	1	63	c.51G>A	c.(49-51)CAG>CAA	p.Q17Q		NM_021013	NP_066293	O76011	KRT34_HUMAN	keratin 34	17	Head.				epidermis development	intermediate filament	protein binding|structural molecule activity			central_nervous_system(1)	1		Breast(137;0.000496)				TCTCCTTCCTCTGCAGTCCTT	0.458		NaN											0	0	0	0.010504	0	19	84									
ACLY	47	broad.mit.edu	37	17	40070073	40070073	+	Silent	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr17:40070073G>A	uc002hyg.2	-	2	217	c.54C>T	c.(52-54)TTC>TTT	p.F18F	ACLY_uc002hyh.2_Silent_p.F18F|ACLY_uc002hyi.2_Silent_p.F72F|ACLY_uc010wfx.1_Silent_p.F72F|ACLY_uc010wfy.1_Silent_p.F18F	NM_001096	NP_001087	P53396	ACLY_HUMAN	ATP citrate lyase isoform 1	18					ATP catabolic process|cellular carbohydrate metabolic process|citrate metabolic process|coenzyme A metabolic process|energy reserve metabolic process|long-chain fatty-acyl-CoA biosynthetic process|positive regulation of cellular metabolic process|triglyceride biosynthetic process	citrate lyase complex|cytosol|nucleus	ATP binding|ATP citrate synthase activity|citrate (pro-3S)-lyase activity|metal ion binding|protein binding|succinate-CoA ligase (ADP-forming) activity			ovary(2)|central_nervous_system(1)	3		Breast(137;0.000143)				TGGTACAGATGAACTTGTAAA	0.562		NaN											0	0	0	0.004656	0	25	178									
GRN	2896	broad.mit.edu	37	17	42429721	42429721	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr17:42429721G>C	uc002igp.1	+	12	1645	c.1426G>C	c.(1426-1428)GAG>CAG	p.E476Q	GRN_uc002igr.1_Missense_Mutation_p.E270Q	NM_002087	NP_002078	P28799	GRN_HUMAN	granulin precursor	476					signal transduction	extracellular space	cytokine activity|growth factor activity			ovary(2)|central_nervous_system(2)|skin(1)	5		Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.189)		TGTGTGCTGCGAGGATCGCCA	0.637		NaN											0	0	0	0.001168	0	6	28									
PLCD3	113026	broad.mit.edu	37	17	43196285	43196285	+	Silent	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr17:43196285C>T	uc002iib.2	-	5	924	c.810G>A	c.(808-810)CTG>CTA	p.L270L		NM_133373	NP_588614	Q8N3E9	PLCD3_HUMAN	phospholipase C delta 3	270	EF-hand 3.				intracellular signal transduction|lipid catabolic process	cleavage furrow|cytoplasm|membrane	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			breast(2)|lung(1)	3					Phosphatidylserine(DB00144)	CAGGGGCACTCAGCACGCGGT	0.637		NaN											0	0	0	0.001984	0	7	11									
NFE2L1	4779	broad.mit.edu	37	17	46128694	46128694	+	Missense_Mutation	SNP	A	A	G	rs117666459	by1000genomes	TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr17:46128694A>G	uc002imz.3	+	2	865	c.214A>G	c.(214-216)ATA>GTA	p.I72V	NFE2L1_uc002ina.3_Missense_Mutation_p.I72V|NFE2L1_uc002inb.3_Missense_Mutation_p.I72V|NFE2L1_uc002inc.1_Missense_Mutation_p.I72V	NM_003204	NP_003195	Q14494	NF2L1_HUMAN	nuclear factor erythroid 2-like 1	72					anatomical structure morphogenesis|heme biosynthetic process|inflammatory response|transcription from RNA polymerase II promoter	nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription cofactor activity			skin(1)	1						CCCCAAGAGCATAGACCTGGA	0.567		NaN											0	0	0	0.003755	0	38	115									
SAMD14	201191	broad.mit.edu	37	17	48191613	48191613	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr17:48191613C>T	uc002iqg.2	-	8	1179	c.880G>A	c.(880-882)GGG>AGG	p.G294R	SAMD14_uc002iqd.2_Missense_Mutation_p.G77R|SAMD14_uc002iqe.2_Missense_Mutation_p.G77R|SAMD14_uc002iqf.2_Missense_Mutation_p.G322R	NM_174920	NP_777580	Q8IZD0	SAM14_HUMAN	sterile alpha motif domain containing 14	294											0						TGCCAGGGCCCACTGGGGATC	0.597		NaN											0	0	0	0.010729	0	10	36									
XYLT2	64132	broad.mit.edu	37	17	48434547	48434547	+	Silent	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr17:48434547G>A	uc002iqo.2	+	9	1984	c.1875G>A	c.(1873-1875)CTG>CTA	p.L625L	XYLT2_uc010dbo.2_Intron	NM_022167	NP_071450	Q9H1B5	XYLT2_HUMAN	xylosyltransferase II	625	Lumenal (Potential).				glycosaminoglycan biosynthetic process	endoplasmic reticulum membrane|Golgi membrane|integral to membrane	acetylglucosaminyltransferase activity|protein xylosyltransferase activity			pancreas(1)	1	Breast(11;7.18e-19)					AGATGTGGCTGATGCCCCAAG	0.632		NaN											0	0	0	0.001168	0	6	15									
LRRC59	55379	broad.mit.edu	37	17	48460409	48460409	+	Silent	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr17:48460409G>A	uc002iqt.2	-	7	1018	c.864C>T	c.(862-864)GTC>GTT	p.V288V		NM_018509	NP_060979	Q96AG4	LRC59_HUMAN	leucine rich repeat containing 59	288	Lumenal (Potential).					endoplasmic reticulum membrane|integral to membrane|microsome|mitochondrial nucleoid	protein binding			central_nervous_system(1)	1	Breast(11;5.62e-19)		BRCA - Breast invasive adenocarcinoma(22;2.43e-08)			GTAGACCCTGGACCGCATTGT	0.597		NaN											0	0	0	0.001168	0	6	8									
RAD51C	5889	broad.mit.edu	37	17	56809868	56809868	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr17:56809868C>A	uc002iwu.2	+	8	1031	c.989C>A	c.(988-990)CCC>CAC	p.P330H	RAD51C_uc010woa.1_Missense_Mutation_p.P330H|RAD51C_uc010ddc.2_RNA|RAD51C_uc002iwv.2_RNA|RAD51C_uc002iww.2_RNA	NM_058216	NP_478123	O43502	RA51C_HUMAN	RAD51 homolog C isoform 1	330					blood coagulation|DNA repair	mitochondrion|nucleoplasm|perinuclear region of cytoplasm	ATP binding|DNA binding|DNA-dependent ATPase activity				0	Medulloblastoma(34;0.127)|all_neural(34;0.237)					TACAAGTCACCCAGCCAGAAG	0.328		NaN						Homologous_recombination	Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2				1	0	7.26314e-15	0.007291	7.58155e-15	24	83									
HELZ	9931	broad.mit.edu	37	17	65141898	65141898	+	Silent	SNP	T	T	C			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr17:65141898T>C	uc010wqk.1	-	21	2920	c.2733A>G	c.(2731-2733)GTA>GTG	p.V911V	HELZ_uc002jfv.3_RNA|HELZ_uc002jfx.3_Silent_p.V910V	NM_014877	NP_055692			helicase with zinc finger domain											ovary(1)|pancreas(1)	2	all_cancers(12;1.24e-11)|Breast(2;1.05e-17)|all_epithelial(3;3.87e-13)					TTTTTTCTTGTACATCTTCTC	0.373		NaN											0	0	0	0.008291	0	11	108									
ABCA6	23460	broad.mit.edu	37	17	67075194	67075194	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr17:67075194C>G	uc002jhw.1	-	39	4949	c.4774G>C	c.(4774-4776)GAA>CAA	p.E1592Q		NM_080284	NP_525023	Q8N139	ABCA6_HUMAN	ATP-binding cassette, sub-family A, member 6	1592					transport	integral to membrane	ATP binding|ATPase activity			upper_aerodigestive_tract(2)|large_intestine(2)|ovary(2)|skin(1)	7	Breast(10;5.65e-12)					ACTTCCTGTTCTTTAGAAAGC	0.348		NaN											0	0	0	0.010729	0	12	54									
DNAI2	64446	broad.mit.edu	37	17	72301563	72301563	+	Missense_Mutation	SNP	C	C	T	rs143470009		TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr17:72301563C>T	uc002jkf.2	+	9	1292	c.1193C>T	c.(1192-1194)TCG>TTG	p.S398L	DNAI2_uc002jkg.2_RNA|DNAI2_uc010dfp.2_RNA|uc002jkh.1_3'UTR|DNAI2_uc002jki.2_RNA	NM_023036	NP_075462	Q9GZS0	DNAI2_HUMAN	dynein, axonemal, intermediate polypeptide 2	398	WD 4.				cilium assembly	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	microtubule motor activity			ovary(2)|central_nervous_system(1)	3						AGCCGGGAATCGTCCATCATG	0.622		NaN							Kartagener_syndrome				0	0	0	0.008291	0	11	17									
GRIN2C	2905	broad.mit.edu	37	17	72842905	72842905	+	Missense_Mutation	SNP	T	T	C			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr17:72842905T>C	uc002jlt.1	-	10	2312	c.2156A>G	c.(2155-2157)AAG>AGG	p.K719R	GRIN2C_uc010wrh.1_RNA|GRIN2C_uc002jlu.1_Missense_Mutation_p.K719R	NM_000835	NP_000826	Q14957	NMDE3_HUMAN	N-methyl-D-aspartate receptor subunit 2C	719	Extracellular (Potential).				glutamate signaling pathway	cell junction|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|N-methyl-D-aspartate selective glutamate receptor activity			ovary(2)|breast(2)	4	all_lung(278;0.172)|Lung NSC(278;0.207)				Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)	CCACCCCATCTTGAGGCTGGT	0.617		NaN											0	0	0	0.00278	0	12	26									
OTOP2	92736	broad.mit.edu	37	17	72929508	72929508	+	Silent	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr17:72929508C>T	uc010wrp.1	+	8	1646	c.1557C>T	c.(1555-1557)TTC>TTT	p.F519F	OTOP3_uc010wrq.1_5'Flank|OTOP3_uc010wrr.1_5'Flank	NM_178160	NP_835454	Q7RTS6	OTOP2_HUMAN	otopetrin 2	519						integral to membrane				ovary(3)|large_intestine(1)	4	all_lung(278;0.172)|Lung NSC(278;0.207)					GCCCTCATTTCAGCAACACAG	0.572		NaN											0	0	0	0.00333	0	20	77									
ICT1	3396	broad.mit.edu	37	17	73017052	73017052	+	Silent	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr17:73017052G>A	uc002jmm.2	+	6	575	c.573G>A	c.(571-573)AAG>AAA	p.K191K		NM_001545	NP_001536	Q14197	ICT1_HUMAN	immature colon carcinoma transcript 1 precursor	191					mitochondrial translational termination	mitochondrial large ribosomal subunit	aminoacyl-tRNA hydrolase activity|translation release factor activity, codon nonspecific			ovary(1)|central_nervous_system(1)	2	all_lung(278;0.226)					TGAGACAAAAGAGAATTCATT	0.498		NaN											0	0	0	0.008361	0	30	64									
UNC13D	201294	broad.mit.edu	37	17	73839336	73839336	+	Silent	SNP	G	G	C			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr17:73839336G>C	uc002jpp.2	-	3	545	c.165C>G	c.(163-165)CTC>CTG	p.L55L	UNC13D_uc010wsk.1_Silent_p.L55L|UNC13D_uc002jpq.1_5'UTR|UNC13D_uc010dgq.1_5'Flank	NM_199242	NP_954712	Q70J99	UN13D_HUMAN	unc-13 homolog D	55					positive regulation of exocytosis|regulation of mast cell degranulation	exocytic vesicle|late endosome|lysosome|membrane|recycling endosome	protein binding			upper_aerodigestive_tract(1)|skin(1)	2			all cancers(21;2.11e-06)|Epithelial(20;2.32e-06)|BRCA - Breast invasive adenocarcinoma(9;0.000618)|LUSC - Lung squamous cell carcinoma(166;0.154)			CGTCCTCGTAGAGCAGGGCCC	0.642		NaN							Familial_Hemophagocytic_Lymphohistiocytosis				0	0	0	0.001168	0	5	22									
UBE2O	63893	broad.mit.edu	37	17	74387282	74387282	+	Silent	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr17:74387282G>A	uc002jrm.3	-	18	3686	c.3621C>T	c.(3619-3621)GGC>GGT	p.G1207G	UBE2O_uc002jrl.3_Silent_p.G811G	NM_022066	NP_071349	Q9C0C9	UBE2O_HUMAN	ubiquitin-conjugating enzyme E2O	1207							ATP binding|ubiquitin-protein ligase activity			breast(2)|skin(2)|lung(1)	5						CTGAGGCCAGGCCCTGGGCAC	0.632		NaN											0	0	0	0.00245	0	13	96									
EPB41L3	23136	broad.mit.edu	37	18	5397338	5397338	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr18:5397338C>T	uc002kmt.1	-	18	2646	c.2560G>A	c.(2560-2562)GAG>AAG	p.E854K	EPB41L3_uc010wzh.1_Missense_Mutation_p.E685K|EPB41L3_uc002kmu.1_Missense_Mutation_p.E632K|EPB41L3_uc010dkq.1_Missense_Mutation_p.E523K|EPB41L3_uc002kms.1_Missense_Mutation_p.E89K|EPB41L3_uc010wze.1_Missense_Mutation_p.E159K|EPB41L3_uc010wzf.1_Missense_Mutation_p.E151K|EPB41L3_uc010wzg.1_Missense_Mutation_p.E126K|EPB41L3_uc010dkr.2_Missense_Mutation_p.E246K	NM_012307	NP_036439	Q9Y2J2	E41L3_HUMAN	erythrocyte membrane protein band 4.1-like 3	854	Spectrin--actin-binding (Potential).				cortical actin cytoskeleton organization	cell-cell junction|cytoplasm|cytoskeleton|extrinsic to membrane	actin binding|structural molecule activity			ovary(5)	5						AACACGGTCTCCTGCACCACC	0.602		NaN											0	0	0	0.00308	0	8	40									
KATNAL2	83473	broad.mit.edu	37	18	44626625	44626625	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr18:44626625G>A	uc002lco.2	+	14	1353	c.1159G>A	c.(1159-1161)GAG>AAG	p.E387K	KATNAL2_uc002lcp.3_Missense_Mutation_p.E314K	NM_031303	NP_112593	Q8IYT4	KATL2_HUMAN	katanin p60 subunit A-like 2	459						cytoplasm|microtubule	ATP binding|microtubule-severing ATPase activity			ovary(1)|skin(1)|central_nervous_system(1)|pancreas(1)	4						GCTGTTTCAGGAGACTGAGGG	0.507		NaN									OREG0024959	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.003954	0	23	35									
MYO5B	4645	broad.mit.edu	37	18	47428979	47428980	+	Missense_Mutation	DNP	CC	CC	AA			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr18:47428979_47428980CC>AA	uc002leb.2	-	21	3083_3084	c.2795_2796GG>TT	c.(2794-2796)CGG>CTT	p.R932L	MYO5B_uc002lea.2_Missense_Mutation_p.R73L	NM_001080467	NP_001073936	Q9ULV0	MYO5B_HUMAN	myosin VB	932	Potential.				protein transport	myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			ovary(2)|skin(2)|central_nervous_system(1)	5				READ - Rectum adenocarcinoma(32;0.103)		CATCGATCTTCCGCTGCAGCTG	0.594		NaN											0	0	0	0.004672	0	27	53									
DCC	1630	broad.mit.edu	37	18	50977029	50977029	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr18:50977029G>C	uc002lfe.1	+	23	3976	c.3389G>C	c.(3388-3390)AGA>ACA	p.R1130T	DCC_uc010dpf.1_Missense_Mutation_p.R765T	NM_005215	NP_005206	P43146	DCC_HUMAN	netrin receptor DCC precursor	1130	Cytoplasmic (Potential).				apoptosis|induction of apoptosis|negative regulation of collateral sprouting|negative regulation of dendrite development	cytosol|integral to membrane				skin(8)|ovary(6)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	17		all_cancers(7;0.11)|all_epithelial(6;0.00126)		Colorectal(16;0.0251)|COAD - Colon adenocarcinoma(17;0.0942)		GCCCAGCAGAGAAAGTAGGTA	0.473		NaN											0	0	0	0.001168	0	5	32									
MBD2	8932	broad.mit.edu	37	18	51731413	51731413	+	Silent	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr18:51731413C>T	uc002lfg.1	-	2	886	c.657G>A	c.(655-657)CAG>CAA	p.Q219Q	MBD2_uc002lfh.1_Silent_p.Q219Q	NM_003927	NP_003918	Q9UBB5	MBD2_HUMAN	methyl-CpG binding domain protein 2 isoform 1	219					transcription, DNA-dependent		C2H2 zinc finger domain binding|methyl-CpG binding|satellite DNA binding				0				Colorectal(16;0.0212)|READ - Rectum adenocarcinoma(32;0.188)	Hexobarbital(DB01355)	GTTTGTTCTTCTGTAATTTAC	0.388		NaN											0	0	0	0.01441	0	74	148									
CD226	10666	broad.mit.edu	37	18	67562996	67562996	+	Missense_Mutation	SNP	T	T	C			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr18:67562996T>C	uc010dqo.2	-	3	1115	c.668A>G	c.(667-669)TAC>TGC	p.Y223C	CD226_uc002lkm.3_Missense_Mutation_p.Y223C	NM_006566	NP_006557	Q15762	CD226_HUMAN	CD226 molecule precursor	223	Ig-like C2-type 2.|Extracellular (Potential).				cell adhesion|cell recognition|positive regulation of Fc receptor mediated stimulatory signaling pathway|positive regulation of immunoglobulin mediated immune response|positive regulation of mast cell activation|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target	cell surface|integral to plasma membrane|membrane raft	cell adhesion molecule binding|integrin binding|protein kinase binding|receptor activity				0		Esophageal squamous(42;0.129)				GGCCTGCAAGTAGCAGCGGTA	0.522		NaN											0	0	0	0.00333	0	24	141									
RTTN	25914	broad.mit.edu	37	18	67871418	67871418	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr18:67871418G>C	uc002lkp.2	-	3	369	c.301C>G	c.(301-303)CTG>GTG	p.L101V	RTTN_uc010xfb.1_Translation_Start_Site|RTTN_uc002lkq.1_Missense_Mutation_p.L101V	NM_173630	NP_775901	Q86VV8	RTTN_HUMAN	rotatin	101							binding			ovary(3)|pancreas(2)|skin(1)|breast(1)|central_nervous_system(1)	8		Esophageal squamous(42;0.129)				TCAGCCTGCAGATTTGGCTCC	0.433		NaN											0	0	0	0.007413	0	19	134									
CTDP1	9150	broad.mit.edu	37	18	77474710	77474710	+	Missense_Mutation	SNP	A	A	C			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr18:77474710A>C	uc002lnh.1	+	8	1397	c.1250A>C	c.(1249-1251)CAA>CCA	p.Q417P	CTDP1_uc002lni.1_Missense_Mutation_p.Q417P|CTDP1_uc010drd.1_Missense_Mutation_p.Q417P	NM_004715	NP_004706	Q9Y5B0	CTDP1_HUMAN	CTD (carboxy-terminal domain, RNA polymerase II,	417					positive regulation of viral transcription|protein dephosphorylation|transcription elongation from RNA polymerase II promoter|viral reproduction	nucleoplasm	CTD phosphatase activity|DNA-directed RNA polymerase activity				0		Esophageal squamous(42;0.0157)|Melanoma(33;0.144)		OV - Ovarian serous cystadenocarcinoma(15;5.2e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0277)		ACCAGCAGCCAAGAGCTGGCA	0.746		NaN											0	0	0	0.001984	0	7	4									
ZNF555	148254	broad.mit.edu	37	19	2853251	2853251	+	Nonsense_Mutation	SNP	T	T	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr19:2853251T>A	uc002lwo.2	+	4	1277	c.1188T>A	c.(1186-1188)TAT>TAA	p.Y396*	ZNF555_uc002lwn.3_Nonsense_Mutation_p.Y395*	NM_152791	NP_690004	Q8NEP9	ZN555_HUMAN	zinc finger protein 555	396	C2H2-type 9.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		AGAAACCCTATGAATGCAACC	0.498		NaN											0	0	0	0.006214	0	10	64									
TLE6	79816	broad.mit.edu	37	19	2987903	2987903	+	Silent	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr19:2987903G>A	uc002lwu.2	+	9	664	c.264G>A	c.(262-264)AGG>AGA	p.R88R	TLE6_uc002lwt.2_Silent_p.R211R|TLE6_uc010dtg.2_Silent_p.R211R|TLE6_uc002lwv.2_5'UTR	NM_024760	NP_079036	Q9H808	TLE6_HUMAN	transducin-like enhancer of split 6 isoform 2	88					regulation of transcription, DNA-dependent	nucleus				ovary(1)	1				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TAGCCCCCAGGCCACCTGAGG	0.667		NaN											0	0	0	0.00245	0	13	18									
GNA15	2769	broad.mit.edu	37	19	3157790	3157790	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr19:3157790C>T	uc002lxf.2	+	6	1067	c.809C>T	c.(808-810)ACA>ATA	p.T270I		NM_002068	NP_002059	P30679	GNA15_HUMAN	guanine nucleotide binding protein (G protein),	270					activation of phospholipase C activity by dopamine receptor signaling pathway|activation of phospholipase C activity by muscarinic acetylcholine receptor signaling pathway|elevation of cytosolic calcium ion concentration|G-protein signaling, coupled to cAMP nucleotide second messenger|platelet activation|protein ADP-ribosylation	heterotrimeric G-protein complex	G-protein beta/gamma-subunit complex binding|G-protein-coupled receptor binding|GTP binding|GTPase activity|signal transducer activity			skin(2)	2		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;7.04e-05)|OV - Ovarian serous cystadenocarcinoma(105;5.08e-113)|Epithelial(107;6.19e-111)|all cancers(105;6.19e-103)|BRCA - Breast invasive adenocarcinoma(158;0.00145)|STAD - Stomach adenocarcinoma(1328;0.184)		TTCAAAAGCACATCCGTCATC	0.507		NaN											0	0	0	0.004289	0	36	213									
C19orf28	126321	broad.mit.edu	37	19	3551099	3551099	+	Missense_Mutation	SNP	T	T	C			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr19:3551099T>C	uc002lxz.2	-	2	562	c.392A>G	c.(391-393)TAC>TGC	p.Y131C	C19orf28_uc002lxw.2_Missense_Mutation_p.Y131C|C19orf28_uc002lxx.2_Missense_Mutation_p.Y131C|C19orf28_uc002lxy.2_Missense_Mutation_p.Y122C	NM_174983	NP_778148	Q6NUT3	CS028_HUMAN	hypothetical protein LOC126321 isoform c	131	Helical; (Potential).				transmembrane transport	integral to membrane				breast(1)|pancreas(1)	2		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00251)|STAD - Stomach adenocarcinoma(1328;0.18)		GAACGGGCCGTAGTAGAGGAG	0.637		NaN											0	0	0	0.001168	0	5	22									
EEF2	1938	broad.mit.edu	37	19	3984133	3984133	+	Splice_Site	SNP	C	C	G	rs113603517		TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr19:3984133C>G	uc002lze.2	-	2	301	c.218_splice	c.e2+1	p.T73_splice	SNORD37_uc002lzf.1_5'Flank	NM_001961	NP_001952	P13639	EF2_HUMAN	eukaryotic translation elongation factor 2							cytosol|ribonucleoprotein complex	GTP binding|GTPase activity|protein binding|translation elongation factor activity				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00461)|GBM - Glioblastoma multiforme(1328;0.0223)|STAD - Stomach adenocarcinoma(1328;0.18)		AGGGAGCTCACGTTGACTTGA	0.657		NaN											0	0	0	0.006122	0	17	39									
ACSBG2	81616	broad.mit.edu	37	19	6177390	6177390	+	Nonsense_Mutation	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr19:6177390C>T	uc002mef.1	+	8	1116	c.889C>T	c.(889-891)CAA>TAA	p.Q297*	ACSBG2_uc002mee.1_Nonsense_Mutation_p.Q110*|ACSBG2_uc002meg.1_Nonsense_Mutation_p.Q297*|ACSBG2_uc002meh.1_Nonsense_Mutation_p.Q297*|ACSBG2_uc002mei.1_Nonsense_Mutation_p.Q247*|ACSBG2_uc010xiz.1_Nonsense_Mutation_p.Q297*	NM_030924	NP_112186	Q5FVE4	ACBG2_HUMAN	bubblegum-related acyl-CoA synthetase 2	297					cell differentiation|fatty acid metabolic process|multicellular organismal development|spermatogenesis	membrane|microsome|mitochondrion	acyl-CoA thioesterase activity|ATP binding|long-chain fatty acid-CoA ligase activity			ovary(1)	1						ATACTTTGCTCAAGCAGATGC	0.507		NaN											0	0	0	0.007413	0	20	34									
ZNF557	79230	broad.mit.edu	37	19	7083113	7083113	+	Silent	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr19:7083113C>T	uc002mgb.2	+	8	1115	c.630C>T	c.(628-630)TTC>TTT	p.F210F	ZNF557_uc002mga.2_Silent_p.F217F|ZNF557_uc002mgc.2_Silent_p.F217F	NM_001044388	NP_001037853	Q8N988	ZN557_HUMAN	zinc finger protein 557 isoform b	210	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|pancreas(1)	2				Lung(535;0.179)		GGAAAACCTTCAGCAGCAGAT	0.438		NaN											0	0	0	0.008361	0	32	52									
XAB2	56949	broad.mit.edu	37	19	7684884	7684884	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr19:7684884C>T	uc002mgx.2	-	17	2370	c.2344G>A	c.(2344-2346)GAG>AAG	p.E782K		NM_020196	NP_064581	Q9HCS7	SYF1_HUMAN	XPA binding protein 2	782					transcription, DNA-dependent|transcription-coupled nucleotide-excision repair	catalytic step 2 spliceosome|nucleoplasm	protein binding			central_nervous_system(2)|breast(1)|skin(1)	4						CGCTCCGCCTCAGCCGCCAGC	0.667		NaN						Direct_reversal_of_damage|NER					0	0	0	0.000602	0	4	16									
FBN3	84467	broad.mit.edu	37	19	8136970	8136970	+	Silent	SNP	G	G	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr19:8136970G>T	uc002mjf.2	-	62	8071	c.8050C>A	c.(8050-8052)CGG>AGG	p.R2684R	FBN3_uc002mje.2_Silent_p.R480R	NM_032447	NP_115823	Q75N90	FBN3_HUMAN	fibrillin 3 precursor	2684						proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			ovary(6)|skin(3)|pancreas(1)|central_nervous_system(1)	11						GGCCGGTCCCGAGGGGAGAGG	0.647		NaN											1	0	2.2871e-25	0.007835	2.41309e-25	37	142									
MUC16	94025	broad.mit.edu	37	19	9071731	9071731	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr19:9071731C>T	uc002mkp.2	-	3	15919	c.15715G>A	c.(15715-15717)GAT>AAT	p.D5239N		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	5241	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GTGGACTTATCATGGTCTGGG	0.478		NaN											0	0	0	0.009535	0	29	156									
MUC16	94025	broad.mit.edu	37	19	9077704	9077704	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr19:9077704G>A	uc002mkp.2	-	3	9946	c.9742C>T	c.(9742-9744)CAG>TAG	p.Q3248*		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	3249	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GCTGTGGACTGAAGGGTGACT	0.517		NaN											0	0	0	0.00333	0	23	166									
KEAP1	9817	broad.mit.edu	37	19	10610637	10610637	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr19:10610637C>T	uc002moq.1	-	2	229	c.73G>A	c.(73-75)GAG>AAG	p.E25K	KEAP1_uc002mor.1_Missense_Mutation_p.E25K	NM_012289	NP_036421	Q14145	KEAP1_HUMAN	kelch-like ECH-associated protein 1	25					regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|midbody|nucleus	protein binding			lung(12)|breast(3)|ovary(1)|pancreas(1)	17			OV - Ovarian serous cystadenocarcinoma(20;2.71e-09)|Epithelial(33;2.32e-06)|all cancers(31;1.42e-05)			CCTGCCCCCTCAGGGCACTGT	0.652		NaN											0	0	0	0.007413	0	19	73									
ZNF700	90592	broad.mit.edu	37	19	12060204	12060204	+	Silent	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr19:12060204C>T	uc002msu.2	+	4	1491	c.1365C>T	c.(1363-1365)TTC>TTT	p.F455F	ZNF700_uc010xme.1_Silent_p.F473F|ZNF763_uc010xmf.1_Intron	NM_144566	NP_653167	Q9H0M5	ZN700_HUMAN	zinc finger protein 700	455	C2H2-type 9.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						GGAAAGCCTTCAGATCTACCT	0.488		NaN											0	0	0	0.012319	0	23	94									
BRD4	23476	broad.mit.edu	37	19	15367816	15367816	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr19:15367816C>T	uc002nar.2	-	8	1732	c.1510G>A	c.(1510-1512)GAG>AAG	p.E504K	BRD4_uc002nas.2_Missense_Mutation_p.E504K|BRD4_uc002nat.3_Missense_Mutation_p.E504K|BRD4_uc002nau.3_Missense_Mutation_p.E504K	NM_058243	NP_490597	O60885	BRD4_HUMAN	bromodomain-containing protein 4 isoform long	504					interspecies interaction between organisms|positive regulation of G2/M transition of mitotic cell cycle|positive regulation of transcription elongation from RNA polymerase II promoter|regulation of transcription involved in G1 phase of mitotic cell cycle	condensed nuclear chromosome|cytoplasm	protein binding			ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(3;3.02e-24)|Epithelial(3;4.71e-20)|all cancers(3;2.26e-18)			CGCTCCTCCTCAGAGTCATCA	0.647		NaN	T	NUT|C15orf55	lethal midline carcinoma of young people								0	0	0	0.009096	0	3	3									
CHERP	10523	broad.mit.edu	37	19	16633881	16633881	+	Silent	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr19:16633881C>T	uc002nei.1	-	11	2036	c.1962G>A	c.(1960-1962)CTG>CTA	p.L654L	MED26_uc002nee.2_Intron|CHERP_uc010xpg.1_Silent_p.L193L	NM_006387	NP_006378	Q8IWX8	CHERP_HUMAN	calcium homeostasis endoplasmic reticulum	654	Pro-rich.				cellular calcium ion homeostasis|negative regulation of cell proliferation|nervous system development|RNA processing	endoplasmic reticulum|perinuclear region of cytoplasm	RNA binding			ovary(2)	2						GGGGGGCCATCAGCCCAGCAG	0.617		NaN											0	0	0	0.013537	0	13	64									
CHERP	10523	broad.mit.edu	37	19	16634026	16634026	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr19:16634026C>G	uc002nei.1	-	11	1891	c.1817G>C	c.(1816-1818)GGA>GCA	p.G606A	MED26_uc002nee.2_Intron|CHERP_uc010xpg.1_Missense_Mutation_p.G145A	NM_006387	NP_006378	Q8IWX8	CHERP_HUMAN	calcium homeostasis endoplasmic reticulum	606	Pro-rich.				cellular calcium ion homeostasis|negative regulation of cell proliferation|nervous system development|RNA processing	endoplasmic reticulum|perinuclear region of cytoplasm	RNA binding			ovary(2)	2						GTGCTGGGGTCCAGCCCAAGG	0.662		NaN											0	0	0	0.004007	0	14	82									
CHERP	10523	broad.mit.edu	37	19	16640540	16640540	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr19:16640540C>T	uc002nei.1	-	8	1122	c.1048G>A	c.(1048-1050)GAA>AAA	p.E350K	MED26_uc002nee.2_Intron	NM_006387	NP_006378	Q8IWX8	CHERP_HUMAN	calcium homeostasis endoplasmic reticulum	350					cellular calcium ion homeostasis|negative regulation of cell proliferation|nervous system development|RNA processing	endoplasmic reticulum|perinuclear region of cytoplasm	RNA binding			ovary(2)	2						GCCTTGACTTCAGCCTCCATC	0.562		NaN											0	0	0	0.00308	0	6	4									
MYO9B	4650	broad.mit.edu	37	19	17213295	17213295	+	Silent	SNP	C	C	G			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr19:17213295C>G	uc010eak.2	+	2	920	c.768C>G	c.(766-768)CTC>CTG	p.L256L	MYO9B_uc002nfi.2_Silent_p.L256L|MYO9B_uc002nfj.1_Silent_p.L256L	NM_004145	NP_004136	Q13459	MYO9B_HUMAN	myosin IXB isoform 1	256	Myosin head-like.				actin filament-based movement	cell cortex|cytosol|filamentous actin|myosin complex|perinuclear region of cytoplasm	actin binding|ADP binding|ATP binding|ATPase activity|calmodulin binding|metal ion binding|microfilament motor activity|Rho GTPase activator activity			breast(1)	1						TCCACTGCCTCACCGCCCTCA	0.642		NaN											0	0	0	0.004482	0	8	20									
ABHD8	79575	broad.mit.edu	37	19	17405304	17405304	+	Silent	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr19:17405304G>A	uc002ngb.3	-	4	1182	c.942C>T	c.(940-942)TTC>TTT	p.F314F		NM_024527	NP_078803	Q96I13	ABHD8_HUMAN	abhydrolase domain containing 8	314							hydrolase activity				0						CTTGGCGGGCGAAGCCGGCCC	0.647		NaN											0	0	0	0.001855	0	12	94									
ANO8	57719	broad.mit.edu	37	19	17440786	17440786	+	Silent	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr19:17440786G>A	uc002ngf.2	-	11	1470	c.1311C>T	c.(1309-1311)CTC>CTT	p.L437L	ANO8_uc010eap.2_RNA	NM_020959	NP_066010	Q9HCE9	ANO8_HUMAN	anoctamin 8	437	Extracellular (Potential).|Leu-rich.					chloride channel complex	chloride channel activity			ovary(3)	3						CTTTGATGATGAGGTGCTTCT	0.622		NaN											0	0	0	0.003163	0	15	88									
PDE4C	5143	broad.mit.edu	37	19	18321950	18321950	+	Nonsense_Mutation	SNP	G	G	C			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr19:18321950G>C	uc010xqc.1	-	15	2408	c.1928C>G	c.(1927-1929)TCA>TGA	p.S643*	PDE4C_uc002nik.3_Nonsense_Mutation_p.S643*|PDE4C_uc002nil.3_Nonsense_Mutation_p.S643*|PDE4C_uc002nif.3_Nonsense_Mutation_p.S412*|PDE4C_uc002nig.3_Nonsense_Mutation_p.S358*|PDE4C_uc002nih.3_Nonsense_Mutation_p.S413*|PDE4C_uc010ebk.2_Nonsense_Mutation_p.S537*|PDE4C_uc002nii.3_Nonsense_Mutation_p.S611*|PDE4C_uc010ebl.2_Nonsense_Mutation_p.S357*	NM_001098819	NP_001092289	Q08493	PDE4C_HUMAN	phosphodiesterase 4C isoform PDE4C-2	643					signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding			ovary(2)|skin(2)|central_nervous_system(1)	5					Dyphylline(DB00651)	GGTGAGGTCTGAGGGACTTCG	0.468		NaN											0	0	0	0.001855	0	12	127									
UPF1	5976	broad.mit.edu	37	19	18963840	18963840	+	Silent	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr19:18963840G>A	uc002nkg.2	+	7	1292	c.1017G>A	c.(1015-1017)AAG>AAA	p.K339K	UPF1_uc002nkf.2_Silent_p.K339K	NM_002911	NP_002902	Q92900	RENT1_HUMAN	regulator of nonsense transcripts 1	339	Sufficient for interaction with RENT2.				cell cycle|DNA repair|DNA replication|histone mRNA catabolic process|mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of translational termination	chromatin|cytoplasmic mRNA processing body|exon-exon junction complex	ATP binding|ATP-dependent RNA helicase activity|chromatin binding|DNA binding|protein binding|protein binding|RNA binding|zinc ion binding			ovary(1)|central_nervous_system(1)	2						GCCTTAACAAGAAGAGAATCG	0.453		NaN											0	0	0	0.01441	0	54	101									
SFRS14	10147	broad.mit.edu	37	19	19135806	19135806	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr19:19135806C>G	uc002nkx.2	-	3	1497	c.1351G>C	c.(1351-1353)GAG>CAG	p.E451Q	SFRS14_uc002nkz.1_Missense_Mutation_p.E465Q|SFRS14_uc002nla.1_Missense_Mutation_p.E451Q|SFRS14_uc002nlb.2_Missense_Mutation_p.E451Q|SFRS14_uc010xqk.1_Missense_Mutation_p.E220Q	NM_014884	NP_055699	Q8IX01	SUGP2_HUMAN	splicing factor, arginine/serine-rich 14	451					mRNA processing|RNA splicing	nucleus	RNA binding				0			OV - Ovarian serous cystadenocarcinoma(5;3.05e-05)|Epithelial(12;0.00161)			ACACTTAGCTCGTAGGCATTG	0.473		NaN											0	0	0	0.007835	0	42	253									
SF4	57794	broad.mit.edu	37	19	19431303	19431303	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr19:19431303C>T	uc002nmh.2	-	1	5	c.3G>A	c.(1-3)ATG>ATA	p.M1I	SF4_uc002nmi.2_5'UTR|SF4_uc002nmj.2_5'UTR|SF4_uc010xqr.1_RNA|SF4_uc010xqs.1_RNA|KIAA0892_uc002nmk.3_5'Flank	NM_172231	NP_757386	Q8IWZ8	SUGP1_HUMAN	splicing factor 4	1					nuclear mRNA splicing, via spliceosome	nucleoplasm|spliceosomal complex	RNA binding				0						TCTTGAGACTCATCCAATCCC	0.612		NaN											0	0	0	0.005443	0	29	84									
GATAD2A	54815	broad.mit.edu	37	19	19612021	19612021	+	Silent	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr19:19612021G>A	uc010xqt.1	+	9	1608	c.1296G>A	c.(1294-1296)AAG>AAA	p.K432K	GATAD2A_uc010xqu.1_Silent_p.K61K|GATAD2A_uc010xqv.1_Silent_p.K452K|GATAD2A_uc010xqw.1_Silent_p.K260K	NM_017660	NP_060130	Q86YP4	P66A_HUMAN	GATA zinc finger domain containing 2A	432	GATA-type.				DNA methylation|negative regulation of transcription, DNA-dependent	nuclear speck|NuRD complex	protein binding, bridging|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0						GGGAGGAGAAGAGCGGCGCCA	0.622		NaN											0	0	0	0.00308	0	7	44									
ZNF737	100129842	broad.mit.edu	37	19	20728335	20728335	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr19:20728335C>G	uc002npa.2	-	4	854	c.674G>C	c.(673-675)GGA>GCA	p.G225A		NM_001159293	NP_001152765	C9JHM3	C9JHM3_HUMAN	zinc finger protein 737	225					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding			ovary(1)	1						CCGTTTCTCTCCAGTATGAAT	0.403		NaN											0	0	0	0.004672	0	3	56									
KIAA0355	9710	broad.mit.edu	37	19	34818939	34818939	+	Silent	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr19:34818939G>A	uc002nvd.3	+	6	1846	c.987G>A	c.(985-987)CAG>CAA	p.Q329Q		NM_014686	NP_055501	O15063	K0355_HUMAN	hypothetical protein LOC9710	329										ovary(1)	1	Esophageal squamous(110;0.162)					GGCGGAGGCAGACACCCCCGC	0.617		NaN											0	0	0	0.009718	0	42	107									
LSR	51599	broad.mit.edu	37	19	35758034	35758034	+	Silent	SNP	C	C	G			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr19:35758034C>G	uc002nyl.2	+	9	1534	c.1311C>G	c.(1309-1311)CTC>CTG	p.L437L	LSR_uc002nym.2_Silent_p.L418L|LSR_uc002nyn.2_Silent_p.L369L|LSR_uc002nyo.2_Silent_p.L417L|LSR_uc010xsr.1_Silent_p.L329L|LSR_uc002nyp.2_Silent_p.L379L|USF2_uc010xss.1_5'Flank|USF2_uc002nyq.1_5'Flank|USF2_uc002nyr.1_5'Flank|USF2_uc002nys.1_5'Flank|USF2_uc002nyt.1_5'Flank|USF2_uc002nyu.1_5'Flank|USF2_uc002nyv.1_5'Flank	NM_205834	NP_991403	Q86X29	LSR_HUMAN	lipolysis stimulated lipoprotein receptor	437	Cytoplasmic (Potential).				embryo development|liver development	chylomicron|integral to membrane|low-density lipoprotein particle|plasma membrane|very-low-density lipoprotein particle	receptor activity				0	all_lung(56;3.91e-09)|Lung NSC(56;5.64e-09)|Esophageal squamous(110;0.162)		Epithelial(14;1.33e-19)|OV - Ovarian serous cystadenocarcinoma(14;1.29e-18)|all cancers(14;7.11e-17)|LUSC - Lung squamous cell carcinoma(66;0.0417)			TCACCTCCCTCCACGAGGACG	0.682		NaN											0	0	0	0.001984	0	6	33									
WDR62	284403	broad.mit.edu	37	19	36591653	36591653	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr19:36591653G>A	uc002odc.2	+	23	2834	c.2743G>A	c.(2743-2745)GAG>AAG	p.E915K	WDR62_uc002odd.2_Missense_Mutation_p.E915K	NM_173636	NP_775907	O43379	WDR62_HUMAN	WD repeat domain 62 isoform 2	915					cerebral cortex development	nucleus					0	Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.06)			CCCATAGTCAGAGAGTCCCCA	0.627		NaN											0	0	0	0.010504	0	17	103									
ZFP82	284406	broad.mit.edu	37	19	36884578	36884578	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr19:36884578C>T	uc002ody.1	-	5	899	c.664G>A	c.(664-666)GGT>AGT	p.G222S		NM_133466	NP_597723	Q8N141	ZFP82_HUMAN	zinc finger protein 82 homolog	222					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|skin(1)	2						AGTTTTTCACCAGAATGAAGT	0.413		NaN											0	0	0	0.007291	0	29	118									
ZNF829	374899	broad.mit.edu	37	19	37382767	37382767	+	Nonsense_Mutation	SNP	G	G	C			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr19:37382767G>C	uc002ofa.1	-	6	1288	c.926C>G	c.(925-927)TCA>TGA	p.S309*	ZNF345_uc002oez.2_Intron	NM_001037232	NP_001032309	Q3KNS6	ZN829_HUMAN	zinc finger protein 829	309	C2H2-type 6.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	Esophageal squamous(110;0.183)		COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			AATAAGCCTTGAGTGTTGAGT	0.383		NaN											0	0	0	0.00499	0	18	216									
ZNF527	84503	broad.mit.edu	37	19	37880276	37880276	+	Missense_Mutation	SNP	T	T	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr19:37880276T>A	uc010efk.1	+	5	1436	c.1325T>A	c.(1324-1326)TTC>TAC	p.F442Y	ZNF527_uc002ogf.3_Missense_Mutation_p.F410Y|ZNF527_uc010xtq.1_RNA	NM_032453	NP_115829	Q8NB42	ZN527_HUMAN	zinc finger protein 527	442	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			GAGAAACCCTTCAAATGTAGT	0.428		NaN											0	0	0	0.001984	0	7	249									
ZNF607	84775	broad.mit.edu	37	19	38190458	38190458	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr19:38190458G>T	uc002ohc.1	-	5	1170	c.574C>A	c.(574-576)CAT>AAT	p.H192N	ZNF607_uc002ohb.1_Missense_Mutation_p.H191N	NM_032689	NP_116078	Q96SK3	ZN607_HUMAN	zinc finger protein 607	192	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0			UCEC - Uterine corpus endometrioid carcinoma (49;0.0775)			TTCTCAACATGAACTTTCCCA	0.393		NaN											1	0	4.10826e-27	0.01441	4.35021e-27	51	646									
FCGBP	8857	broad.mit.edu	37	19	40408603	40408603	+	Silent	SNP	G	G	C			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr19:40408603G>C	uc002omp.3	-	8	4244	c.4236C>G	c.(4234-4236)GCC>GCG	p.A1412A		NM_003890	NP_003881	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein precursor	1412	VWFD 3.					extracellular region	protein binding			ovary(4)|skin(4)|central_nervous_system(1)	9	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			CGAACTCATTGGCGTTGCCTG	0.632		NaN											0	0	0	0.00499	0	16	44									
PSMC4	5704	broad.mit.edu	37	19	40480725	40480725	+	Silent	SNP	T	T	C			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr19:40480725T>C	uc002omq.2	+	6	700	c.663T>C	c.(661-663)CAT>CAC	p.H221H	PSMC4_uc002omr.2_Silent_p.H190H	NM_006503	NP_006494	P43686	PRS6B_HUMAN	proteasome 26S ATPase subunit 4 isoform 1	221					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	mitochondrion|nucleus|proteasome complex	ATP binding|ATPase activity|protein binding			ovary(1)	1	all_cancers(60;9.55e-06)|all_lung(34;1.17e-07)|Lung NSC(34;1.41e-07)|Ovarian(47;0.0925)					CGGTGGCACATCACACAACAG	0.597		NaN											0	0	0	0.006214	0	8	29									
BCKDHA	593	broad.mit.edu	37	19	41884361	41884361	+	Silent	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr19:41884361C>T	uc002oqm.3	+	2	498	c.147C>T	c.(145-147)TTC>TTT	p.F49F	CYP2F1_uc010xvw.1_Intron|TMEM91_uc002oqi.2_Silent_p.F49F|TMEM91_uc010ehq.2_Silent_p.F49F|TMEM91_uc002oql.2_Silent_p.F49F|TMEM91_uc010ehr.2_Silent_p.F49F|TMEM91_uc010ehs.2_Silent_p.F49F|TMEM91_uc010eht.2_Silent_p.F49F|TMEM91_uc002oqk.3_Silent_p.F49F|TMEM91_uc002oqn.2_Silent_p.F49F	NM_000709	NP_000700	P12694	ODBA_HUMAN	branched chain keto acid dehydrogenase E1, alpha	Error:Variant_position_missing_in_P12694_after_alignment					branched chain family amino acid catabolic process	mitochondrial alpha-ketoglutarate dehydrogenase complex	3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity|alpha-ketoacid dehydrogenase activity|carboxy-lyase activity|metal ion binding|protein binding				0						GTTTGCAGTTCCTGTCACCGC	0.617		NaN											0	0	0	0.008871	0	19	41									
CEACAM5	1048	broad.mit.edu	37	19	42213827	42213827	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr19:42213827G>T	uc002ork.2	+	2	414	c.293G>T	c.(292-294)CGA>CTA	p.R98L	CEACAM5_uc010ehz.1_Missense_Mutation_p.R98L|CEACAM5_uc002orj.1_Missense_Mutation_p.R98L|CEACAM5_uc002orl.2_Missense_Mutation_p.R98L	NM_004363	NP_004354	P06731	CEAM5_HUMAN	carcinoembryonic antigen-related cell adhesion	98	Ig-like 1.					anchored to membrane|basolateral plasma membrane|integral to plasma membrane				skin(2)	2				OV - Ovarian serous cystadenocarcinoma(3;0.00278)|all cancers(3;0.00625)|Epithelial(262;0.0379)|GBM - Glioblastoma multiforme(1328;0.142)		TACAGTGGTCGAGAGATAATA	0.448		NaN											1	0	3.21399e-22	0.004878	3.38295e-22	39	229									
GSK3A	2931	broad.mit.edu	37	19	42744116	42744116	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr19:42744116C>G	uc002otb.1	-	2	581	c.462G>C	c.(460-462)AAG>AAC	p.K154N	GSK3A_uc002ota.1_Missense_Mutation_p.K72N|GSK3A_uc002otc.2_RNA	NM_019884	NP_063937	P49840	GSK3A_HUMAN	glycogen synthase kinase 3 alpha	154	Protein kinase.				insulin receptor signaling pathway|negative regulation of glucose import|negative regulation of insulin receptor signaling pathway|negative regulation of transferase activity|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of protein catabolic process	beta-catenin destruction complex|cytosol	ATP binding|protein kinase A catalytic subunit binding|protein serine/threonine kinase activity|tau-protein kinase activity			ovary(2)|lung(2)	4		Prostate(69;0.00682)				CCTTGAACCTCTTGTCCTGGA	0.567		NaN											0	0	0	0.000602	0	5	33									
ERCC2	2068	broad.mit.edu	37	19	45873455	45873455	+	Missense_Mutation	SNP	T	T	C			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08			T	C	T	T		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr19:45873455T>C	uc002pbj.2	-	2	88	c.41A>G	c.(40-42)TAC>TGC	p.Y14C	ERCC2_uc010ejz.2_Missense_Mutation_p.Y14C|ERCC2_uc002pbk.2_5'UTR|ERCC2_uc002pbl.3_5'UTR|ERCC2_uc010xxj.1_RNA	NM_000400	NP_000391	P18074	ERCC2_HUMAN	excision repair cross-complementing rodent	14	Helicase ATP-binding.				cell cycle checkpoint|chromosome segregation|hair cell differentiation|induction of apoptosis|interspecies interaction between organisms|mRNA capping|nucleotide-excision repair, DNA damage removal|nucleotide-excision repair, DNA incision|positive regulation of transcription from RNA polymerase II promoter|positive regulation of viral transcription|protein phosphorylation|response to oxidative stress|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase I promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|UV protection|viral reproduction	cytoplasm|holo TFIIH complex|MMXD complex	5'-3' DNA helicase activity|ATP binding|ATP-dependent DNA helicase activity|DNA binding|iron-sulfur cluster binding|metal ion binding|protein C-terminus binding|protein N-terminus binding			lung(2)|pancreas(1)	3		Ovarian(192;0.0728)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.0226)		GATGTAGTCGTACGGGAAGTA	0.682		NaN	Mis|N|F|S			skin basal cell|skin squamous cell|melanoma		Direct_reversal_of_damage|NER	Xeroderma_Pigmentosum				0	0	0	0.001168	0	4	27									
PPP1R13L	10848	broad.mit.edu	37	19	45899596	45899596	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr19:45899596G>A	uc002pbn.2	-	5	888	c.811C>T	c.(811-813)CGC>TGC	p.R271C	PPP1R13L_uc002pbo.2_Missense_Mutation_p.R271C|PPP1R13L_uc002pbp.2_Missense_Mutation_p.R271C	NM_006663	NP_006654	Q8WUF5	IASPP_HUMAN	protein phosphatase 1, regulatory subunit 13	271	Pro-rich.				apoptosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	transcription corepressor activity|transcription factor binding			skin(1)	1		all_neural(266;0.224)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.0182)		CACCACTCACGTTCATAGCTC	0.652		NaN											0	0	0	0.004007	0	15	41									
FAM83E	54854	broad.mit.edu	37	19	49116416	49116416	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr19:49116416C>T	uc002pjn.2	-	1	279	c.214G>A	c.(214-216)GAA>AAA	p.E72K		NM_017708	NP_060178	Q2M2I3	FA83E_HUMAN	hypothetical protein LOC54854	72										ovary(1)	1		all_epithelial(76;2.38e-06)|all_lung(116;4.89e-06)|Lung NSC(112;9.34e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.000102)|all cancers(93;0.000117)|GBM - Glioblastoma multiforme(486;0.00627)|Epithelial(262;0.0158)		GTCCAGTCTTCAGCTGCCGCT	0.672		NaN											0	0	0	0.006122	0	15	8									
PPP1R15A	23645	broad.mit.edu	37	19	49377076	49377076	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr19:49377076G>A	uc002pky.3	+	2	855	c.586G>A	c.(586-588)GAA>AAA	p.E196K		NM_014330	NP_055145	O75807	PR15A_HUMAN	protein phosphatase 1, regulatory subunit 15A	196	Glu-rich.				apoptosis|cell cycle arrest|regulation of translation|response to DNA damage stimulus	endoplasmic reticulum	protein binding			lung(1)	1		all_epithelial(76;5.29e-07)|all_lung(116;1.7e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.000244)|all cancers(93;0.000694)|GBM - Glioblastoma multiforme(486;0.0222)|Epithelial(262;0.033)		GGAGGACGATGAAGAAGCTGT	0.532		NaN											0	0	0	0.00623	0	40	56									
GYS1	2997	broad.mit.edu	37	19	49481249	49481249	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr19:49481249G>A	uc002plp.2	-	10	1481	c.1240C>T	c.(1240-1242)CCC>TCC	p.P414S	GYS1_uc010xzy.1_Missense_Mutation_p.P47S|GYS1_uc010emm.2_Missense_Mutation_p.P350S|GYS1_uc010xzz.1_Missense_Mutation_p.P334S|GYS1_uc010yaa.1_RNA	NM_002103	NP_002094	P13807	GYS1_HUMAN	glycogen synthase 1 (muscle) isoform 1	414					glucose metabolic process|glycogen biosynthetic process	cytosol	glycogen (starch) synthase activity|protein binding			ovary(2)	2		all_lung(116;4.89e-05)|Lung NSC(112;8.3e-05)|all_epithelial(76;8.64e-05)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000164)|all cancers(93;0.000226)|GBM - Glioblastoma multiforme(486;0.00561)|Epithelial(262;0.0286)		TTCATGTCGGGAAGGCTCCCA	0.542		NaN											0	0	0	0.01441	0	66	89									
HRC	3270	broad.mit.edu	37	19	49658329	49658329	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr19:49658329C>T	uc002pmv.2	-	1	353	c.166G>A	c.(166-168)GAG>AAG	p.E56K	TRPM4_uc002pmw.2_5'Flank|TRPM4_uc010emu.2_5'Flank|TRPM4_uc010yak.1_5'Flank|TRPM4_uc002pmx.2_5'Flank|TRPM4_uc010emv.2_5'Flank|TRPM4_uc010yal.1_5'Flank	NM_002152	NP_002143	P23327	SRCH_HUMAN	histidine rich calcium binding protein	56					muscle contraction	sarcoplasmic reticulum lumen	calcium ion binding			ovary(1)	1		all_lung(116;3.16e-06)|Lung NSC(112;6.25e-06)|all_neural(266;0.0189)|Ovarian(192;0.0392)		all cancers(93;2.01e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.00019)|GBM - Glioblastoma multiforme(486;0.00279)|Epithelial(262;0.00622)		TGGCGAAGCTCTGCTGATGCC	0.597		NaN											0	0	0	0.01441	0	58	121									
ZNF320	162967	broad.mit.edu	37	19	53383882	53383882	+	Silent	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr19:53383882G>A	uc002qag.2	-	4	1688	c.1497C>T	c.(1495-1497)TGC>TGT	p.C499C	ZNF320_uc010eqh.1_5'Flank|ZNF320_uc010eqi.1_Intron|ZNF320_uc002qah.2_Silent_p.C445C|ZNF320_uc002qai.2_Silent_p.C499C	NM_207333	NP_997216	A2RRD8	ZN320_HUMAN	zinc finger protein 320	499					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				GBM - Glioblastoma multiforme(134;0.0534)		TATACTCATTGCACTTGAAAC	0.368		NaN											0	0	0	0.004656	0	22	140									
ZNF816A	125893	broad.mit.edu	37	19	53454109	53454109	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr19:53454109G>A	uc002qal.1	-	5	1220	c.919C>T	c.(919-921)CAT>TAT	p.H307Y	ZNF321_uc010eqj.2_Intron|ZNF321_uc002qak.1_Intron|ZNF816A_uc002qam.1_Missense_Mutation_p.H291Y	NM_001031665	NP_001026835	Q0VGE8	ZN816_HUMAN	zinc finger protein 816A	307	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				GBM - Glioblastoma multiforme(134;0.0313)		TCTCCAGTATGAAGTCTACGA	0.428		NaN											0	0	0	0.01441	0	152	185									
ZNF160	90338	broad.mit.edu	37	19	53573363	53573363	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr19:53573363C>G	uc010eqk.2	-	7	840	c.424G>C	c.(424-426)GAG>CAG	p.E142Q	ZNF160_uc002qaq.3_Missense_Mutation_p.E142Q|ZNF160_uc002qar.3_Missense_Mutation_p.E142Q	NM_001102603	NP_001096073	Q9HCG1	ZN160_HUMAN	zinc finger protein 160	142					hemopoiesis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)	1				GBM - Glioblastoma multiforme(134;0.02)		CATTGACACTCAAAATCATGC	0.423		NaN											0	0	0	0.01441	0	125	154									
RPS9	6203	broad.mit.edu	37	19	54705081	54705081	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr19:54705081G>C	uc002qdx.2	+	2	85	c.29G>C	c.(28-30)CGC>CCC	p.R10P	RPS9_uc002qdy.2_Missense_Mutation_p.R10P|RPS9_uc002qdz.2_Missense_Mutation_p.R10P|RPS9_uc002qea.2_Missense_Mutation_p.R10P|RPS9_uc002qeb.2_Missense_Mutation_p.R10P|RPS9_uc002qec.2_RNA|RPS9_uc002qed.1_Missense_Mutation_p.R10P	NM_001013	NP_001004	P46781	RS9_HUMAN	ribosomal protein S9	10					endocrine pancreas development|positive regulation of cell proliferation|translational elongation|translational termination|viral transcription	cytosolic small ribosomal subunit|nucleolus	protein binding|rRNA binding|structural constituent of ribosome|translation regulator activity			breast(1)	1	all_cancers(19;0.00723)|all_epithelial(19;0.00389)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.18)		TGGGTTTGTCGCAAAACTTAT	0.617		NaN											0	0	0	0.00278	0	22	48									
TNNI3	7137	broad.mit.edu	37	19	55667621	55667621	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr19:55667621C>T	uc002qjg.3	-	5	230	c.230G>A	c.(229-231)AGC>AAC	p.S77N	TNNI3_uc010yft.1_Missense_Mutation_p.S69N	NM_000363	NP_000354	P19429	TNNI3_HUMAN	troponin I, cardiac	77	Involved in binding TNC.				cardiac muscle contraction|cellular calcium ion homeostasis|muscle filament sliding|negative regulation of ATPase activity|regulation of systemic arterial blood pressure by ischemic conditions|vasculogenesis|ventricular cardiac muscle tissue morphogenesis	cytosol|troponin complex	actin binding|calcium channel inhibitor activity|calcium-dependent protein binding|protein domain specific binding|protein kinase binding|troponin C binding|troponin T binding			lung(1)|pancreas(1)	2			BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0452)		GCAGCGGGTGCTCAGAGCGCG	0.657		NaN											0	0	0	0.000602	0	4	16									
ZNF460	10794	broad.mit.edu	37	19	57802811	57802811	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr19:57802811G>C	uc002qog.2	+	3	1224	c.902G>C	c.(901-903)AGC>ACC	p.S301T	ZNF460_uc010ygv.1_Missense_Mutation_p.S260T	NM_006635	NP_006626	Q14592	ZN460_HUMAN	zinc finger protein 460	301	C2H2-type 4.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0694)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		CATAACAAGAGCCACAATGAG	0.473		NaN											0	0	0	0.014323	0	22	141									
ZSCAN1	284312	broad.mit.edu	37	19	58565117	58565117	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr19:58565117G>A	uc002qrc.1	+	6	1172	c.925G>A	c.(925-927)GAG>AAG	p.E309K		NM_182572	NP_872378	Q8NBB4	ZSCA1_HUMAN	zinc finger and SCAN domain containing 1	309	C2H2-type 1.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2		Colorectal(82;5.46e-05)|all_neural(62;0.0182)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0152)		CCACTTCATCGAGCACCAGAA	0.627		NaN											0	0	0	0.003954	0	25	39									
SLC27A5	10998	broad.mit.edu	37	19	59011983	59011983	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr19:59011983G>A	uc002qtc.2	-	5	1383	c.1273C>T	c.(1273-1275)CCT>TCT	p.P425S	SLC27A5_uc002qtb.2_5'Flank	NM_012254	NP_036386	Q9Y2P5	S27A5_HUMAN	solute carrier family 27 (fatty acid	425	Cytoplasmic (Probable).				bile acid and bile salt transport|bile acid biosynthetic process|very long-chain fatty acid metabolic process	endoplasmic reticulum membrane|integral to membrane	ATP binding|cholate-CoA ligase activity|long-chain fatty acid-CoA ligase activity				0		all_cancers(17;4.4e-22)|all_epithelial(17;2.15e-16)|Lung NSC(17;1.24e-06)|all_lung(17;5.41e-06)|Colorectal(82;3.46e-05)|Renal(17;0.00179)|all_neural(62;0.00607)|Ovarian(87;0.0443)|Breast(46;0.0928)|Medulloblastoma(540;0.184)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0168)|Lung(386;0.181)		ATCCGAATAGGACCGAAGCGC	0.587		NaN											0	0	0	0.004289	0	35	48									
GREB1	9687	broad.mit.edu	37	2	11765299	11765299	+	Silent	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr2:11765299C>T	uc002rbk.1	+	24	4467	c.4167C>T	c.(4165-4167)GAC>GAT	p.D1389D	GREB1_uc002rbp.1_Silent_p.D387D	NM_014668	NP_055483	Q4ZG55	GREB1_HUMAN	growth regulation by estrogen in breast cancer 1	1389						integral to membrane				ovary(1)	1	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.115)|OV - Ovarian serous cystadenocarcinoma(76;0.186)		AAGAATCTGACTGGCATTATC	0.378		NaN											0	0	0	0.00623	0	41	263									
GREB1	9687	broad.mit.edu	37	2	11774306	11774306	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr2:11774306C>T	uc002rbk.1	+	29	5341	c.5041C>T	c.(5041-5043)CAC>TAC	p.H1681Y	GREB1_uc002rbp.1_Missense_Mutation_p.H679Y	NM_014668	NP_055483	Q4ZG55	GREB1_HUMAN	growth regulation by estrogen in breast cancer 1	1681						integral to membrane				ovary(1)	1	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.115)|OV - Ovarian serous cystadenocarcinoma(76;0.186)		CATCATGCAGCACATCGAGGC	0.622		NaN											0	0	0	0.006122	0	17	111									
RAD51AP2	729475	broad.mit.edu	37	2	17699508	17699508	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr2:17699508C>T	uc002rcl.1	-	1	199	c.175G>A	c.(175-177)GAG>AAG	p.E59K	RAD51AP2_uc010exn.1_Missense_Mutation_p.E50K	NM_001099218	NP_001092688	Q09MP3	R51A2_HUMAN	RAD51 associated protein 2	59										ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.158)					TTTTCCGCCTCAGACAAGCGA	0.547		NaN											0	0	0	0.006999	0	40	124									
VSNL1	7447	broad.mit.edu	37	2	17773477	17773477	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr2:17773477G>C	uc002rcm.2	+	2	520	c.136G>C	c.(136-138)GAG>CAG	p.E46Q		NM_003385	NP_003376	P62760	VISL1_HUMAN	visinin-like 1	46	EF-hand 1.						calcium ion binding			ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.158)					GCTAAATCTCGAGGAATTTCA	0.428		NaN											0	0	0	0.012213	0	30	209									
PUM2	23369	broad.mit.edu	37	2	20451400	20451400	+	Silent	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr2:20451400C>T	uc002rds.1	-	20	3164	c.3141G>A	c.(3139-3141)TTG>TTA	p.L1047L	PUM2_uc002rdq.1_Silent_p.L426L|PUM2_uc002rdt.1_Silent_p.L1047L|PUM2_uc002rdr.2_Silent_p.L907L|PUM2_uc010yjy.1_Silent_p.L968L|PUM2_uc002rdu.1_Silent_p.L1047L|PUM2_uc010yjz.1_Silent_p.L986L	NM_015317	NP_056132	Q8TB72	PUM2_HUMAN	pumilio homolog 2	1049					regulation of translation	perinuclear region of cytoplasm|stress granule	protein binding|RNA binding			ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GGCTATTCTTCAAATAATACT	0.378		NaN											0	0	0	0.01441	0	84	219									
KIF3C	3797	broad.mit.edu	37	2	26204414	26204414	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr2:26204414C>T	uc002rgu.2	-	1	1030	c.373G>A	c.(373-375)GAG>AAG	p.E125K	KIF3C_uc010eyj.1_RNA|KIF3C_uc010ykr.1_Missense_Mutation_p.E125K	NM_002254	NP_002245	O14782	KIF3C_HUMAN	kinesin family member 3C	125	Kinesin-motor.				blood coagulation|microtubule-based movement	cytosol|kinesin complex|microtubule	ATP binding|microtubule motor activity			ovary(3)|skin(1)	4	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					AAGATGTGCTCAAAGGCATTC	0.592		NaN											0	0	0	0.006122	0	19	114									
GTF3C2	2976	broad.mit.edu	37	2	27566319	27566319	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr2:27566319C>T	uc002rjv.1	-	3	466	c.103G>A	c.(103-105)GAT>AAT	p.D35N	GTF3C2_uc002rju.1_Missense_Mutation_p.D46N|GTF3C2_uc002rjw.1_Missense_Mutation_p.D35N|GTF3C2_uc010eyz.1_Missense_Mutation_p.D35N	NM_001521	NP_001512	Q8WUA4	TF3C2_HUMAN	general transcription factor IIIC, polypeptide	35						transcription factor TFIIIC complex				ovary(1)|skin(1)	2	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GTCTTGACATCAAGCTGATTT	0.547		NaN											0	0	0	0.01441	0	82	199									
PPM1G	5496	broad.mit.edu	37	2	27609992	27609992	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr2:27609992C>T	uc002rkl.2	-	3	261	c.154G>A	c.(154-156)GAG>AAG	p.E52K	PPM1G_uc002rkm.2_5'UTR	NM_002707	NP_002698	O15355	PPM1G_HUMAN	protein phosphatase 1G	52					cell cycle arrest|protein dephosphorylation	cytoplasm|nucleus|protein serine/threonine phosphatase complex	metal ion binding|protein serine/threonine phosphatase activity			ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)					ATGGCTGTCTCACTGTCCAGC	0.448		NaN											0	0	0	0.005524	0	31	56									
XDH	7498	broad.mit.edu	37	2	31572632	31572632	+	Silent	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr2:31572632G>A	uc002rnv.1	-	26	2968	c.2889C>T	c.(2887-2889)TTC>TTT	p.F963F		NM_000379	NP_000370	P47989	XDH_HUMAN	xanthine dehydrogenase	963					purine nucleotide catabolic process|xanthine catabolic process	cytosol|extracellular region|peroxisome	2 iron, 2 sulfur cluster binding|electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|molybdopterin cofactor binding|protein homodimerization activity|xanthine dehydrogenase activity|xanthine oxidase activity			skin(4)|breast(2)|ovary(1)|central_nervous_system(1)	8	Acute lymphoblastic leukemia(172;0.155)				Allopurinol(DB00437)|Carvedilol(DB01136)|Daunorubicin(DB00694)|Deferoxamine(DB00746)|Desflurane(DB01189)|Menadione(DB00170)|Mercaptopurine(DB01033)|Methotrexate(DB00563)|NADH(DB00157)|Nitrofurazone(DB00336)|Papaverine(DB01113)|Procarbazine(DB01168)|Pyrazinamide(DB00339)|Rasburicase(DB00049)|Spermine(DB00127)|Trifluoperazine(DB00831)|Vitamin E(DB00163)	TGGGCAAGGTGAAACCCTCAA	0.498		NaN											0	0	0	0.01441	0	52	202									
SPAST	6683	broad.mit.edu	37	2	32289086	32289086	+	Silent	SNP	G	G	C			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr2:32289086G>C	uc002roc.2	+	1	407	c.186G>C	c.(184-186)GCG>GCC	p.A62A	SPAST_uc002rod.2_Silent_p.A62A	NM_014946	NP_055761	Q9UBP0	SPAST_HUMAN	spastin isoform 1	62	Required for interaction with SSNA1 and microtubules.|Required for interaction with RTN1.|Nuclear export signal.|Required for interaction with ATL1.|Helical; (Potential).|Required for midbody localization.				cell cycle|cell death|cell differentiation|cytokinesis, completion of separation|ER to Golgi vesicle-mediated transport|microtubule bundle formation|microtubule severing|nervous system development|protein hexamerization|protein homooligomerization	endoplasmic reticulum|endosome|integral to membrane|microtubule|microtubule organizing center|nucleus|perinuclear region of cytoplasm|spindle	alpha-tubulin binding|ATP binding|beta-tubulin binding|microtubule binding|microtubule-severing ATPase activity			breast(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.208)					TAGGCTTCGCGCTGCTGCGTT	0.502		NaN											0	0	0	0.00308	0	7	15									
SLC30A6	55676	broad.mit.edu	37	2	32419049	32419049	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr2:32419049G>A	uc002roe.1	+	8	530	c.493G>A	c.(493-495)GAA>AAA	p.E165K	SLC30A6_uc002rof.1_Missense_Mutation_p.E205K|SLC30A6_uc010ymw.1_Missense_Mutation_p.E136K|SLC30A6_uc010ezr.1_Missense_Mutation_p.E165K|SLC30A6_uc002rog.1_5'UTR|SLC30A6_uc010ezs.1_Missense_Mutation_p.E91K|SLC30A6_uc002roh.1_5'UTR	NM_017964	NP_060434	Q6NXT4	ZNT6_HUMAN	solute carrier family 30 (zinc transporter),	165	Cytoplasmic (Potential).					Golgi membrane|integral to membrane	zinc ion transmembrane transporter activity				0	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.208)					TTATGTCTCAGAAGGTATGTT	0.313		NaN											0	0	0	0.004656	0	27	187									
BIRC6	57448	broad.mit.edu	37	2	32740283	32740283	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr2:32740283G>A	uc010ezu.2	+	55	10929	c.10795G>A	c.(10795-10797)GCA>ACA	p.A3599T		NM_016252	NP_057336	Q9NR09	BIRC6_HUMAN	baculoviral IAP repeat-containing 6	3599					anti-apoptosis|apoptosis	intracellular	acid-amino acid ligase activity|cysteine-type endopeptidase inhibitor activity|protein binding			ovary(5)|skin(4)|lung(2)|central_nervous_system(1)|breast(1)|pancreas(1)	14	Acute lymphoblastic leukemia(172;0.155)					CTCTAAAAATGCACAAGCACC	0.408		NaN											0	0	0	0.013537	0	12	104									
RASGRP3	25780	broad.mit.edu	37	2	33745672	33745672	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr2:33745672C>A	uc002rox.2	+	7	916	c.289C>A	c.(289-291)CGT>AGT	p.R97S	RASGRP3_uc010ync.1_Missense_Mutation_p.R97S|RASGRP3_uc002roy.2_Missense_Mutation_p.R97S	NM_170672	NP_733772	Q8IV61	GRP3_HUMAN	RAS guanyl releasing protein 3 (calcium and	97	N-terminal Ras-GEF.				MAPKKK cascade|small GTPase mediated signal transduction	integral to plasma membrane|intracellular	calcium ion binding|diacylglycerol binding|guanyl-nucleotide exchange factor activity|protein binding|Rap GTPase activator activity|signal transducer activity			lung(3)|ovary(1)|pancreas(1)	5	all_hematologic(175;0.115)					TGGTTTGATTCGTATGACTGA	0.423		NaN											1	0	5.10652e-33	0.01441	5.4203e-33	65	333									
GALM	130589	broad.mit.edu	37	2	38893363	38893363	+	Silent	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr2:38893363G>A	uc002rqy.2	+	1	312	c.60G>A	c.(58-60)GAG>GAA	p.E20E		NM_138801	NP_620156	Q96C23	GALM_HUMAN	galactose mutarotase	20					hexose metabolic process	cytoplasm	aldose 1-epimerase activity|carbohydrate binding				0		all_hematologic(82;0.248)				GGACAGTGGAGAAGTTCCAGC	0.597		NaN											0	0	0	0.003163	0	16	45									
DHX57	90957	broad.mit.edu	37	2	39042771	39042771	+	Silent	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr2:39042771G>A	uc002rrf.2	-	20	3597	c.3498C>T	c.(3496-3498)TTC>TTT	p.F1166F	DHX57_uc002rrd.3_Silent_p.F550F|DHX57_uc002rre.2_Silent_p.F599F	NM_198963	NP_945314	Q6P158	DHX57_HUMAN	DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57	1166							ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding|zinc ion binding			ovary(1)|lung(1)|skin(1)	3		all_hematologic(82;0.248)				ACAGTTCCGTGAATTGTCGTT	0.443		NaN											0	0	0	0.01441	0	46	116									
THADA	63892	broad.mit.edu	37	2	43458299	43458299	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr2:43458299G>A	uc002rsw.3	-	38	6002	c.5650C>T	c.(5650-5652)CAG>TAG	p.Q1884*	THADA_uc010far.2_Nonsense_Mutation_p.Q1079*|THADA_uc002rsx.3_Nonsense_Mutation_p.Q1884*|THADA_uc002rsy.3_RNA	NM_001083953	NP_001077422	Q6YHU6	THADA_HUMAN	thyroid adenoma associated	1884							binding			ovary(2)|skin(1)	3		Acute lymphoblastic leukemia(82;0.00361)|all_hematologic(82;0.00837)				CTGAAGAACTGAGACAGGAGG	0.532		NaN											0	0	0	0.013537	0	12	28									
TTC7A	57217	broad.mit.edu	37	2	47249004	47249004	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr2:47249004G>A	uc002rvo.2	+	12	1764	c.1396G>A	c.(1396-1398)GAG>AAG	p.E466K	TTC7A_uc002rvm.2_Missense_Mutation_p.E432K|TTC7A_uc002rvn.1_Missense_Mutation_p.E347K|TTC7A_uc010fbb.2_Missense_Mutation_p.E466K|TTC7A_uc010fbc.2_Missense_Mutation_p.E112K|TTC7A_uc002rvp.2_Missense_Mutation_p.E347K|TTC7A_uc002rvq.2_Missense_Mutation_p.E206K|TTC7A_uc002rvr.2_Intron	NM_020458	NP_065191	Q9ULT0	TTC7A_HUMAN	tetratricopeptide repeat domain 7A	466							binding			breast(1)|skin(1)	2		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.18)	Lung(47;0.0792)|LUSC - Lung squamous cell carcinoma(58;0.114)			TTTGCAGCTAGAGGAAGCAGA	0.562		NaN											0	0	0	0.004878	0	38	99									
XPO1	7514	broad.mit.edu	37	2	61710158	61710158	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr2:61710158G>C	uc002sbj.2	-	22	3474	c.2746C>G	c.(2746-2748)CAA>GAA	p.Q916E	XPO1_uc010fcl.2_Missense_Mutation_p.Q912E|XPO1_uc010ypn.1_Missense_Mutation_p.Q912E|XPO1_uc002sbk.2_Missense_Mutation_p.Q477E|XPO1_uc002sbg.2_Missense_Mutation_p.Q113E|XPO1_uc002sbh.2_Missense_Mutation_p.Q563E	NM_003400	NP_003391	O14980	XPO1_HUMAN	exportin 1	916	HEAT 8.				intracellular protein transport|mitotic prometaphase|mRNA metabolic process|mRNA transport|viral genome transport in host cell|viral infectious cycle	annulate lamellae|Cajal body|cytosol|kinetochore|nuclear envelope|nucleolus|ribonucleoprotein complex	protein binding|protein transporter activity|RNA binding			ovary(1)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|skin(1)	4			LUSC - Lung squamous cell carcinoma(7;5.71e-05)|Epithelial(17;0.0662)|all cancers(80;0.226)			AAATAAGTTTGATAAAAACTC	0.333		NaN											0	0	0	0.005524	0	39	97									
PELI1	57162	broad.mit.edu	37	2	64335432	64335432	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr2:64335432C>T	uc002scs.3	-	1	4052	c.13G>A	c.(13-15)GAT>AAT	p.D5N	PELI1_uc002sct.3_Missense_Mutation_p.D5N|PELI1_uc002scu.1_5'Flank	NM_020651	NP_065702	Q96FA3	PELI1_HUMAN	pellino protein	5					innate immune response|MyD88-dependent toll-like receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	cytosol				ovary(1)	1						TTTTCTTGATCAGGAGAAAAC	0.383		NaN											0	0	0	0.01441	0	72	177									
NAGK	55577	broad.mit.edu	37	2	71298938	71298938	+	Silent	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr2:71298938C>T	uc002shp.3	+	4	742	c.336C>T	c.(334-336)ATC>ATT	p.I112I	NAGK_uc010fea.2_RNA|NAGK_uc002shq.3_5'UTR|NAGK_uc002shr.2_Silent_p.I61I	NM_017567	NP_060037	Q9UJ70	NAGK_HUMAN	N-Acetylglucosamine kinase	112					N-acetylglucosamine metabolic process|N-acetylmannosamine metabolic process		ATP binding|N-acetylglucosamine kinase activity|protein binding				0					N-Acetyl-D-glucosamine(DB00141)	CCGGCTCCATCGCCACAGCTA	0.547		NaN											0	0	0	0.009096	0	3	42									
CCDC142	84865	broad.mit.edu	37	2	74708006	74708006	+	Silent	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr2:74708006G>A	uc002slr.2	-	5	1786	c.1393C>T	c.(1393-1395)CTG>TTG	p.L465L	TTC31_uc002sls.2_5'Flank|TTC31_uc010yrv.1_5'Flank|TTC31_uc002slt.2_5'Flank|TTC31_uc002slu.2_5'Flank|CCDC142_uc002slo.2_RNA|CCDC142_uc002slq.2_Silent_p.L458L|CCDC142_uc002slp.2_Silent_p.L465L	NM_032779	NP_116168	Q17RM4	CC142_HUMAN	coiled-coil domain containing 142	465										central_nervous_system(1)	1						TCATGCAACAGAGGCTTTGGG	0.572		NaN											0	0	0	0.00623	0	39	100									
LRRTM1	347730	broad.mit.edu	37	2	80529640	80529640	+	Silent	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr2:80529640G>A	uc002sok.1	-	2	1575	c.1305C>T	c.(1303-1305)CTC>CTT	p.L435L	CTNNA2_uc010yse.1_Intron|CTNNA2_uc010ysf.1_Intron|CTNNA2_uc010ysg.1_Intron|CTNNA2_uc010ysh.1_Intron|CTNNA2_uc010ysi.1_5'Flank|LRRTM1_uc002soj.3_RNA	NM_178839	NP_849161	Q86UE6	LRRT1_HUMAN	leucine rich repeat transmembrane neuronal 1	435	Helical; (Potential).					axon|endoplasmic reticulum membrane|growth cone|integral to membrane				ovary(3)|upper_aerodigestive_tract(1)|skin(1)	5						AGGAGAAGATGAGGGCCATGG	0.622		NaN								HNSCC(69;0.2)			0	0	0	0.010504	0	20	45									
C2orf89	129293	broad.mit.edu	37	2	85097505	85097505	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr2:85097505C>T	uc010ysl.1	-	2	602	c.513G>A	c.(511-513)ATG>ATA	p.M171I	C2orf89_uc002sou.3_Missense_Mutation_p.M171I|C2orf89_uc010fgc.1_Missense_Mutation_p.M171I	NM_001080824	NP_001074293	Q86V40	CB089_HUMAN	hypothetical protein LOC129293 precursor	171	Extracellular (Potential).					integral to membrane				ovary(1)	1						GGGAGTTGACCATGAGCATCA	0.582		NaN											0	0	0	0.01441	0	54	135									
GGCX	2677	broad.mit.edu	37	2	85777223	85777223	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr2:85777223C>T	uc002sps.2	-	15	2217	c.2111G>A	c.(2110-2112)CGA>CAA	p.R704Q	GGCX_uc010yss.1_Missense_Mutation_p.R520Q|GGCX_uc010yst.1_Missense_Mutation_p.R647Q	NM_000821	NP_000812	P38435	VKGC_HUMAN	gamma-glutamyl carboxylase isoform 1	704	Lumenal (Potential).				blood coagulation|peptidyl-glutamic acid carboxylation|post-translational protein modification	endoplasmic reticulum membrane|integral to membrane|membrane fraction	gamma-glutamyl carboxylase activity			ovary(1)	1					Anisindione(DB01125)|Coagulation Factor IX(DB00100)|Coagulation factor VIIa(DB00036)|Drotrecogin alfa(DB00055)|L-Glutamic Acid(DB00142)|Menadione(DB00170)|Phytonadione(DB01022)	TATCAGATTTCGAAGTGAGAT	0.463		NaN											0	0	0	0.003954	0	21	77									
USP39	10713	broad.mit.edu	37	2	85857963	85857963	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr2:85857963G>A	uc002sqe.2	+	6	879	c.843G>A	c.(841-843)ATG>ATA	p.M281I	USP39_uc002sqb.2_Missense_Mutation_p.M12I|USP39_uc010ysu.1_Missense_Mutation_p.M203I|USP39_uc010ysv.1_Missense_Mutation_p.M178I|USP39_uc010fgn.1_Missense_Mutation_p.M281I|USP39_uc002sqf.2_Missense_Mutation_p.M281I|USP39_uc002sqg.2_Missense_Mutation_p.M281I|USP39_uc010fgo.2_Missense_Mutation_p.M281I	NM_006590	NP_006581	Q53GS9	SNUT2_HUMAN	ubiquitin specific protease 39	281					spliceosome assembly|ubiquitin-dependent protein catabolic process	nucleus	protein binding|ubiquitin thiolesterase activity|zinc ion binding			ovary(1)	1						GAGAGCTGATGAGAAAGCTCT	0.448		NaN											0	0	0	0.01441	0	89	216									
CD8A	925	broad.mit.edu	37	2	87017667	87017667	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr2:87017667C>T	uc002srt.2	-	2	1076	c.187G>A	c.(187-189)GCC>ACC	p.A63T	RMND5A_uc002srs.3_Intron|CD8A_uc002srv.2_Missense_Mutation_p.A63T|CD8A_uc010ytn.1_Missense_Mutation_p.A104T|CD8A_uc002sru.2_Missense_Mutation_p.A63T	NM_001768	NP_001759	P01732	CD8A_HUMAN	CD8 antigen alpha polypeptide isoform 1	63	Ig-like V-type.|Extracellular (Potential).				antigen processing and presentation|regulation of immune response|transmembrane receptor protein tyrosine kinase signaling pathway	extracellular region|integral to plasma membrane|T cell receptor complex	coreceptor activity|MHC class I protein binding			ovary(1)	1						CTGGCGGCGGCGCCGCGCGGC	0.672		NaN											0	0	0	0.014323	0	23	36									
ZNF514	84874	broad.mit.edu	37	2	95815496	95815496	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr2:95815496G>A	uc002sue.1	-	5	1108	c.734C>T	c.(733-735)TCA>TTA	p.S245L	ZNF514_uc002sud.1_Missense_Mutation_p.S318L	NM_032788	NP_116177	Q96K75	ZN514_HUMAN	zinc finger protein 514	245	C2H2-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						AATAAGGGATGAAATATGACC	0.458		NaN											0	0	0	0.01441	0	78	172									
ITPRIPL1	150771	broad.mit.edu	37	2	96992597	96992597	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr2:96992597G>A	uc002svx.2	+	3	563	c.228G>A	c.(226-228)TGG>TGA	p.W76*	ITPRIPL1_uc010yuk.1_Nonsense_Mutation_p.W68*|ITPRIPL1_uc002svy.2_Nonsense_Mutation_p.W84*|ITPRIPL1_uc010yul.1_Nonsense_Mutation_p.W68*	NM_001008949	NP_001008949	Q6GPH6	IPIL1_HUMAN	inositol 1,4,5-triphosphate receptor interacting	76	Extracellular (Potential).					integral to membrane				central_nervous_system(2)|ovary(1)	3						AGAACTTCTGGACAGGAGACA	0.577		NaN											0	0	0	0.012213	0	32	77									
ARID5A	10865	broad.mit.edu	37	2	97217382	97217382	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr2:97217382G>C	uc002swe.2	+	7	1217	c.1117G>C	c.(1117-1119)GGG>CGG	p.G373R	ARID5A_uc010yuq.1_Missense_Mutation_p.G321R|ARID5A_uc002swf.2_Missense_Mutation_p.G209R|ARID5A_uc002swg.2_Missense_Mutation_p.G321R	NM_212481	NP_997646	Q03989	ARI5A_HUMAN	AT rich interactive domain 5A	373					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus	DNA binding				0						GGTGCTATTGGGGCCTCCTGG	0.587		NaN											0	0	0	0.004482	0	8	22									
FER1L5	90342	broad.mit.edu	37	2	97365766	97365766	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr2:97365766G>A	uc010fia.2	+	43	4960	c.4960G>A	c.(4960-4962)GAG>AAG	p.E1654K	FER1L5_uc002sws.3_Missense_Mutation_p.E372K|FER1L5_uc002swt.3_Missense_Mutation_p.E372K|FER1L5_uc010yus.1_Missense_Mutation_p.E371K	NM_001113382	NP_001106853	A0AVI2	FR1L5_HUMAN	fer-1-like 5 isoform 2	1654						integral to membrane				ovary(1)	1						GTTCAGTCCTGAGGAAGATGC	0.527		NaN											0	0	0	0.007291	0	26	50									
COX5B	1329	broad.mit.edu	37	2	98263594	98263594	+	Silent	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr2:98263594G>A	uc002sya.2	+	2	197	c.168G>A	c.(166-168)AAG>AAA	p.K56K		NM_001862	NP_001853	P10606	COX5B_HUMAN	cytochrome c oxidase subunit Vb precursor	56					respiratory electron transport chain|respiratory gaseous exchange	mitochondrial inner membrane	cytochrome-c oxidase activity|metal ion binding				0						TGGCTGCAAAGAAGGGACTGG	0.483		NaN											0	0	0	0.004656	0	26	73									
RPL31	6160	broad.mit.edu	37	2	101622467	101622467	+	Missense_Mutation	SNP	G	G	A	rs11551487		TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr2:101622467G>A	uc002taq.3	+	4	367	c.280G>A	c.(280-282)GAG>AAG	p.E94K	RPL31_uc002tar.3_Missense_Mutation_p.E94K|RPL31_uc010yvu.1_Missense_Mutation_p.E94K|RPL31_uc010yvv.1_Missense_Mutation_p.E94K|RPL31_uc010fiu.1_Missense_Mutation_p.E94K|RPL31_uc002tas.1_Missense_Mutation_p.E94K|RPL31_uc002tat.1_3'UTR	NM_000993	NP_000984	P62899	RL31_HUMAN	ribosomal protein L31 isoform 1	94					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit	protein binding|RNA binding|structural constituent of ribosome				0						AAAACGTAATGAGGATGAAGA	0.388		NaN											0	0	0	0.003163	0	7	68									
RPL31	6160	broad.mit.edu	37	2	101622473	101622473	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr2:101622473G>A	uc002taq.3	+	4	373	c.286G>A	c.(286-288)GAA>AAA	p.E96K	RPL31_uc002tar.3_Missense_Mutation_p.E96K|RPL31_uc010yvu.1_Missense_Mutation_p.E96K|RPL31_uc010yvv.1_Missense_Mutation_p.E96K|RPL31_uc010fiu.1_Missense_Mutation_p.E96K|RPL31_uc002tas.1_Missense_Mutation_p.E96K|RPL31_uc002tat.1_3'UTR	NM_000993	NP_000984	P62899	RL31_HUMAN	ribosomal protein L31 isoform 1	96					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit	protein binding|RNA binding|structural constituent of ribosome				0						TAATGAGGATGAAGATTCACC	0.378		NaN											0	0	0	0.001855	0	5	67									
RPL31	6160	broad.mit.edu	37	2	101622476	101622476	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr2:101622476G>A	uc002taq.3	+	4	376	c.289G>A	c.(289-291)GAT>AAT	p.D97N	RPL31_uc002tar.3_Missense_Mutation_p.D97N|RPL31_uc010yvu.1_Missense_Mutation_p.D97N|RPL31_uc010yvv.1_Missense_Mutation_p.D97N|RPL31_uc010fiu.1_Missense_Mutation_p.D97N|RPL31_uc002tas.1_Missense_Mutation_p.D97N|RPL31_uc002tat.1_3'UTR	NM_000993	NP_000984	P62899	RL31_HUMAN	ribosomal protein L31 isoform 1	97					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit	protein binding|RNA binding|structural constituent of ribosome				0						TGAGGATGAAGATTCACCAAA	0.368		NaN											0	0	0	0.010729	0	5	70									
IL18RAP	8807	broad.mit.edu	37	2	103068411	103068411	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr2:103068411C>T	uc002tbx.2	+	12	2054	c.1570C>T	c.(1570-1572)CCT>TCT	p.P524S	IL18RAP_uc010fiz.2_Missense_Mutation_p.P382S	NM_003853	NP_003844	O95256	I18RA_HUMAN	interleukin 18 receptor accessory protein	524	TIR.|Cytoplasmic (Potential).				cell surface receptor linked signaling pathway|inflammatory response|innate immune response	integral to membrane	transmembrane receptor activity			skin(3)|ovary(2)	5						AGAGTCTCTACCTCATCTCGT	0.418		NaN											0	0	0	0.01441	0	81	174									
IL18RAP	8807	broad.mit.edu	37	2	103068499	103068499	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr2:103068499C>A	uc002tbx.2	+	12	2142	c.1658C>A	c.(1657-1659)GCC>GAC	p.A553D	IL18RAP_uc010fiz.2_Missense_Mutation_p.A411D	NM_003853	NP_003844	O95256	I18RA_HUMAN	interleukin 18 receptor accessory protein	553	TIR.|Cytoplasmic (Potential).				cell surface receptor linked signaling pathway|inflammatory response|innate immune response	integral to membrane	transmembrane receptor activity			skin(3)|ovary(2)	5						AGGTTCTGGGCCAAAATGCGC	0.463		NaN											1	0	5.72124e-26	0.01441	6.04366e-26	77	171									
SLC9A2	6549	broad.mit.edu	37	2	103236427	103236427	+	Silent	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr2:103236427G>A	uc002tca.2	+	1	262	c.120G>A	c.(118-120)CCG>CCA	p.P40P		NM_003048	NP_003039	Q9UBY0	SL9A2_HUMAN	solute carrier family 9 (sodium/hydrogen	40	Cytoplasmic (Potential).					integral to membrane|plasma membrane	sodium:hydrogen antiporter activity			central_nervous_system(3)|skin(3)|breast(2)	8						TGAACGCGCCGAGGGCCATGG	0.448		NaN											0	0	0	0.009096	0	4	15									
GCC2	9648	broad.mit.edu	37	2	109111783	109111783	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr2:109111783G>C	uc002tec.2	+	20	4638	c.4484G>C	c.(4483-4485)CGA>CCA	p.R1495P	GCC2_uc002ted.2_Missense_Mutation_p.R1394P	NM_181453	NP_852118	Q8IWJ2	GCC2_HUMAN	GRIP and coiled-coil domain-containing 2	1495	Potential.				Golgi ribbon formation|late endosome to Golgi transport|microtubule anchoring|microtubule organizing center organization|protein localization in Golgi apparatus|protein targeting to lysosome|recycling endosome to Golgi transport|regulation of protein exit from endoplasmic reticulum	membrane|trans-Golgi network	identical protein binding			ovary(1)	1						AAGAACCTTCGAGAAAGGAGA	0.433		NaN											0	0	0	0.003163	0	15	50									
RANBP2	5903	broad.mit.edu	37	2	109398587	109398587	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr2:109398587G>A	uc002tem.3	+	27	8890	c.8764G>A	c.(8764-8766)GAA>AAA	p.E2922K		NM_006267	NP_006258	P49792	RBP2_HUMAN	RAN binding protein 2	2922	RanBD1 4.				carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA transport|protein folding|protein import into nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear pore	peptidyl-prolyl cis-trans isomerase activity|Ran GTPase binding|zinc ion binding		RANBP2/ALK(16)	soft_tissue(16)|lung(1)|pancreas(1)	18						ATTATAGGTAGAAGTAAAATC	0.353		NaN											0	0	0	0.013537	0	12	88									
ACOXL	55289	broad.mit.edu	37	2	111691109	111691109	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr2:111691109G>A	uc002tgr.3	+	12	1173	c.949G>A	c.(949-951)GAG>AAG	p.E317K	ACOXL_uc010fkc.2_Missense_Mutation_p.E317K|ACOXL_uc010yxk.1_Missense_Mutation_p.E317K	NM_001105516	NP_001098986	Q9NUZ1	ACOXL_HUMAN	acyl-Coenzyme A oxidase-like 2	317					fatty acid beta-oxidation	peroxisome	acyl-CoA dehydrogenase activity|acyl-CoA oxidase activity				0						CCAGGGAAAGGAGCTGGTCAA	0.612		NaN											0	0	0	0.001984	0	7	56									
ANAPC1	64682	broad.mit.edu	37	2	112592358	112592358	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr2:112592358G>A	uc002thi.2	-	19	2454	c.2207C>T	c.(2206-2208)TCA>TTA	p.S736L		NM_022662	NP_073153	Q9H1A4	APC1_HUMAN	anaphase promoting complex subunit 1	736					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination	anaphase-promoting complex|cytosol|nucleoplasm				skin(2)	2						CTTCATCTGTGAAGCTTCTGA	0.383		NaN											0	0	0	0.004007	0	16	70									
MERTK	10461	broad.mit.edu	37	2	112733015	112733015	+	Silent	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr2:112733015G>A	uc002thk.1	+	7	1232	c.1110G>A	c.(1108-1110)GTG>GTA	p.V370V	MERTK_uc002thl.1_Silent_p.V194V	NM_006343	NP_006334	Q12866	MERTK_HUMAN	MER receptor tyrosine kinase precursor	370	Fibronectin type-III 1.|Extracellular (Potential).				cell surface receptor linked signaling pathway|cell-cell signaling|leukocyte migration	integral to plasma membrane|soluble fraction	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(6)|upper_aerodigestive_tract(1)|stomach(1)|kidney(1)	9						GGTCTGCAGTGAGCCCTTGGA	0.483		NaN											0	0	0	0.013114	0	43	97									
MERTK	10461	broad.mit.edu	37	2	112779055	112779055	+	Missense_Mutation	SNP	A	A	G			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr2:112779055A>G	uc002thk.1	+	17	2368	c.2246A>G	c.(2245-2247)TAC>TGC	p.Y749C	MERTK_uc002thl.1_Missense_Mutation_p.Y573C	NM_006343	NP_006334	Q12866	MERTK_HUMAN	MER receptor tyrosine kinase precursor	749	Protein kinase.|Cytoplasmic (Potential).				cell surface receptor linked signaling pathway|cell-cell signaling|leukocyte migration	integral to plasma membrane|soluble fraction	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(6)|upper_aerodigestive_tract(1)|stomach(1)|kidney(1)	9						AAGAAGATTTACAGTGGCGAT	0.483		NaN											0	0	0	0.011902	0	42	122									
SLC20A1	6574	broad.mit.edu	37	2	113417182	113417183	+	Missense_Mutation	DNP	GT	GT	TC			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr2:113417182_113417183GT>TC	uc002tib.2	+	8	1896_1897	c.1450_1451GT>TC	c.(1450-1452)GTC>TCC	p.V484S	SLC20A1_uc002tic.1_Missense_Mutation_p.V296S	NM_005415	NP_005406	Q8WUM9	S20A1_HUMAN	solute carrier family 20 (phosphate	484	Cytoplasmic (Potential).				phosphate metabolic process|positive regulation of I-kappaB kinase/NF-kappaB cascade	integral to plasma membrane	inorganic phosphate transmembrane transporter activity|receptor activity|sodium-dependent phosphate transmembrane transporter activity			ovary(2)	2						AGACATGAGTGTCAAGGCAGAG	0.465		NaN											0	0	0	0.004672	0	89	221									
PSD4	23550	broad.mit.edu	37	2	113941019	113941019	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr2:113941019C>G	uc002tjc.2	+	2	1169	c.986C>G	c.(985-987)TCC>TGC	p.S329C	PSD4_uc002tjd.2_5'UTR|PSD4_uc002tje.2_Missense_Mutation_p.S328C|PSD4_uc002tjf.2_5'Flank	NM_012455	NP_036587	Q8NDX1	PSD4_HUMAN	pleckstrin and Sec7 domain containing 4	329					regulation of ARF protein signal transduction	cytoplasm|plasma membrane	ARF guanyl-nucleotide exchange factor activity			ovary(2)	2						AAACCACACTCCATCTGCTGG	0.617		NaN											0	0	0	0.001984	0	6	44									
PCDP1	200373	broad.mit.edu	37	2	120413990	120413990	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr2:120413990G>A	uc002tmb.2	+	25	2701	c.1609G>A	c.(1609-1611)GAG>AAG	p.E537K		NM_001029996	NP_001025167	Q4G0U5	PCDP1_HUMAN	primary ciliary dyskinesia protein 1	823						cilium	calmodulin binding				0	Colorectal(110;0.196)					GAAGCTGCTCGAGGAGATGAG	0.473		NaN											0	0	0	0.004482	0	7	40									
PTPN4	5775	broad.mit.edu	37	2	120709702	120709702	+	Missense_Mutation	SNP	A	A	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr2:120709702A>T	uc002tmf.1	+	19	2581	c.1810A>T	c.(1810-1812)AAT>TAT	p.N604Y	PTPN4_uc010flj.1_Missense_Mutation_p.N317Y|PTPN4_uc010yyr.1_Missense_Mutation_p.N237Y	NM_002830	NP_002821	P29074	PTN4_HUMAN	protein tyrosine phosphatase, non-receptor type	604						cytoplasm|cytoskeleton|internal side of plasma membrane	cytoskeletal protein binding|non-membrane spanning protein tyrosine phosphatase activity			ovary(2)	2					Alendronate(DB00630)	AGTTCGACCTAATGGTGAGTA	0.284		NaN											0	0	0	0.006122	0	19	142									
SAP130	79595	broad.mit.edu	37	2	128750795	128750795	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr2:128750795G>C	uc002tpp.2	-	12	1653	c.1521C>G	c.(1519-1521)ATC>ATG	p.I507M	SAP130_uc002tpn.2_Missense_Mutation_p.I268M|SAP130_uc002tpo.2_Missense_Mutation_p.I252M|SAP130_uc010fmd.2_Missense_Mutation_p.I507M|SAP130_uc002tpq.1_Missense_Mutation_p.I480M	NM_024545	NP_078821	Q9H0E3	SP130_HUMAN	Sin3A-associated protein, 130kDa isoform b	507					histone H3 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	STAGA complex	transcription coactivator activity			ovary(2)|skin(2)	4	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0771)		CGGAACTGGTGATTGGGGTGT	0.453		NaN											0	0	0	0.013726	0	32	107									
R3HDM1	23518	broad.mit.edu	37	2	136389328	136389328	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr2:136389328G>C	uc002tuo.2	+	8	908	c.538G>C	c.(538-540)GAT>CAT	p.D180H	R3HDM1_uc010fni.2_Missense_Mutation_p.D178H|R3HDM1_uc002tup.2_Missense_Mutation_p.D124H|R3HDM1_uc010zbh.1_Missense_Mutation_p.D12H	NM_015361	NP_056176	Q15032	R3HD1_HUMAN	R3H domain containing 1	180	R3H.						nucleic acid binding			skin(1)	1				BRCA - Breast invasive adenocarcinoma(221;0.127)		AGAAATTTTAGATTTCATTGG	0.323		NaN											0	0	0	0.009535	0	30	43									
DARS	1615	broad.mit.edu	37	2	136682034	136682034	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr2:136682034G>A	uc002tux.1	-	8	783	c.599C>T	c.(598-600)TCT>TTT	p.S200F	DARS_uc010fnj.1_Missense_Mutation_p.S100F	NM_001349	NP_001340	P14868	SYDC_HUMAN	aspartyl-tRNA synthetase	200					aspartyl-tRNA aminoacylation|protein complex assembly	cytosol|nuclear membrane|plasma membrane|soluble fraction	aminoacylase activity|aspartate-tRNA ligase activity|ATP binding|nucleic acid binding|protein binding			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(221;0.168)	L-Aspartic Acid(DB00128)	GCAGATGCCAGACTGGAGACG	0.358		NaN											0	0	0	0.005443	0	26	36									
NMI	9111	broad.mit.edu	37	2	152127234	152127234	+	Silent	SNP	T	T	C			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr2:152127234T>C	uc002txi.2	-	8	1227	c.897A>G	c.(895-897)CAA>CAG	p.Q299Q		NM_004688	NP_004679	Q13287	NMI_HUMAN	N-myc and STAT interactor	299					inflammatory response|JAK-STAT cascade|transcription from RNA polymerase II promoter	cytoplasm|nucleus	nucleotide binding|protein binding|transcription cofactor activity				0				BRCA - Breast invasive adenocarcinoma(221;0.0571)		CTATGTGAGGTTGACCTAGAG	0.348		NaN											0	0	0	0.01441	0	50	82									
RIF1	55183	broad.mit.edu	37	2	152293454	152293454	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr2:152293454C>T	uc002txm.2	+	12	1439	c.1309C>T	c.(1309-1311)CAT>TAT	p.H437Y	RIF1_uc002txl.2_Missense_Mutation_p.H437Y|RIF1_uc010fnv.1_Missense_Mutation_p.H401Y|RIF1_uc002txn.2_Missense_Mutation_p.H437Y|RIF1_uc002txo.2_Missense_Mutation_p.H437Y|RIF1_uc010zby.1_RNA	NM_018151	NP_060621	Q5UIP0	RIF1_HUMAN	RAP1 interacting factor 1	437					cell cycle|response to DNA damage stimulus	chromosome, telomeric region|cytoplasm|nucleus|spindle	binding			ovary(5)|breast(4)|skin(3)|lung(2)|kidney(1)	15				BRCA - Breast invasive adenocarcinoma(221;0.0429)		AATGTTGCTTCATTTCTTGTT	0.398		NaN											0	0	0	0.003163	0	14	54									
KCNH7	90134	broad.mit.edu	37	2	163236516	163236516	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr2:163236516C>T	uc002uch.1	-	14	3190	c.2978G>A	c.(2977-2979)CGA>CAA	p.R993Q		NM_033272	NP_150375	Q9NS40	KCNH7_HUMAN	potassium voltage-gated channel, subfamily H,	993	Cytoplasmic (Potential).				regulation of transcription, DNA-dependent	integral to membrane	protein binding|signal transducer activity			ovary(3)|skin(2)	5					Ibutilide(DB00308)	TTCCCAGCTTCGCATGTCAGT	0.488		NaN											0	0	0	0.01441	0	77	87									
XIRP2	129446	broad.mit.edu	37	2	168105892	168105892	+	Missense_Mutation	SNP	A	A	G			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr2:168105892A>G	uc002udx.2	+	8	8008	c.7990A>G	c.(7990-7992)AGG>GGG	p.R2664G	XIRP2_uc010fpn.2_Intron|XIRP2_uc010fpo.2_Intron|XIRP2_uc010fpp.2_Intron|XIRP2_uc002udy.2_Missense_Mutation_p.R2489G|XIRP2_uc010fpq.2_Missense_Mutation_p.R2442G|XIRP2_uc010fpr.2_Intron|XIRP2_uc010fps.1_Missense_Mutation_p.R10G	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	2489					actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14						ACAAAGCTCAAGGGACATTAT	0.408		NaN											0	0	0	0.00333	0	26	58									
XIRP2	129446	broad.mit.edu	37	2	168106305	168106305	+	Silent	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr2:168106305C>T	uc002udx.2	+	8	8421	c.8403C>T	c.(8401-8403)CCC>CCT	p.P2801P	XIRP2_uc010fpn.2_Intron|XIRP2_uc010fpo.2_Intron|XIRP2_uc010fpp.2_Intron|XIRP2_uc002udy.2_Silent_p.P2626P|XIRP2_uc010fpq.2_Silent_p.P2579P|XIRP2_uc010fpr.2_Intron|XIRP2_uc010fps.1_Silent_p.P147P	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	2626					actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14						AGATGGTTCCCAGGAAGCAAA	0.403		NaN											0	0	0	0.013537	0	12	62									
CHN1	1123	broad.mit.edu	37	2	175742603	175742603	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr2:175742603C>A	uc002uji.2	-	6	1044	c.514G>T	c.(514-516)GAT>TAT	p.D172Y	CHN1_uc010zeq.1_Missense_Mutation_p.D172Y|CHN1_uc002ujj.2_Intron	NM_001822	NP_001813	P15882	CHIN_HUMAN	chimerin (chimaerin) 1 isoform a	172					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|metal ion binding|SH3/SH2 adaptor activity			ovary(2)|skin(1)	3			OV - Ovarian serous cystadenocarcinoma(117;0.226)			CCTGTAGAATCTCTCTCATCA	0.398		NaN	T	TAF15	extraskeletal myxoid chondrosarcoma								1	0	8.10497e-08	0.010504	8.35144e-08	21	82									
TTN	7273	broad.mit.edu	37	2	179399128	179399128	+	Missense_Mutation	SNP	A	A	G			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr2:179399128A>G	uc010zfg.1	-	307	94734	c.94510T>C	c.(94510-94512)TGG>CGG	p.W31504R	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.W25199R|TTN_uc010zfi.1_Missense_Mutation_p.W25132R|TTN_uc010zfj.1_Missense_Mutation_p.W25007R	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	32431							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TGCTTCAACCATGGGTGCTGG	0.428		NaN											0	0	0	0.00623	0	36	73									
TTN	7273	broad.mit.edu	37	2	179401935	179401935	+	Missense_Mutation	SNP	C	C	T	rs72648278		TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr2:179401935C>T	uc010zfg.1	-	305	92421	c.92197G>A	c.(92197-92199)GAA>AAA	p.E30733K	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.E24428K|TTN_uc010zfi.1_Missense_Mutation_p.E24361K|TTN_uc010zfj.1_Missense_Mutation_p.E24236K	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	31660							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AATAGAGCTTCGATCACAATT	0.428		NaN											0	0	0	0.000602	0	4	30									
TTN	7273	broad.mit.edu	37	2	179464127	179464127	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr2:179464127G>A	uc010zfg.1	-	239	48913	c.48689C>T	c.(48688-48690)TCA>TTA	p.S16230L	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.S9925L|TTN_uc010zfi.1_Missense_Mutation_p.S9858L|TTN_uc010zfj.1_Missense_Mutation_p.S9733L	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	17157							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTGATCTGCTGAAACAGATTC	0.383		NaN											0	0	0	0.012319	0	20	58									
TTN	7273	broad.mit.edu	37	2	179604209	179604209	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr2:179604209C>G	uc010zfh.1	-	46	13462	c.13238G>C	c.(13237-13239)GGT>GCT	p.G4413A	TTN_uc010zfg.1_Intron|TTN_uc010zfi.1_Missense_Mutation_p.G4346A|TTN_uc010zfj.1_Missense_Mutation_p.G4221A|TTN_uc002umz.1_Intron	NM_133437	NP_597681	Q8WZ42	TITIN_HUMAN	titin isoform novex-2	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CTCCTCAGTACCACTTTCAGA	0.453		NaN											0	0	0	0.01441	0	46	61									
ANKAR	150709	broad.mit.edu	37	2	190559783	190559783	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr2:190559783G>A	uc002uqw.1	+	5	1171	c.1171G>A	c.(1171-1173)GAA>AAA	p.E391K	ANKAR_uc002uqu.2_RNA	NM_144708	NP_653309	Q7Z5J8	ANKAR_HUMAN	ankyrin and armadillo repeat containing	462						integral to membrane	binding			ovary(2)|pancreas(1)|skin(1)	4			OV - Ovarian serous cystadenocarcinoma(117;0.00156)|Epithelial(96;0.0256)|all cancers(119;0.0744)			AGCCATAAATGAAATAGTGAA	0.318		NaN											0	0	0	0.005524	0	33	31									
SDPR	8436	broad.mit.edu	37	2	192700708	192700708	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr2:192700708C>G	uc002utb.2	-	2	1549	c.1219G>C	c.(1219-1221)GAG>CAG	p.E407Q		NM_004657	NP_004648	O95810	SDPR_HUMAN	serum deprivation response protein	407						caveola|cytosol	phosphatidylserine binding|protein binding			ovary(1)|pancreas(1)	2			OV - Ovarian serous cystadenocarcinoma(117;0.0647)		Phosphatidylserine(DB00144)	TCGGAGCGCTCCGCCTCCTCG	0.617		NaN											0	0	0	0.005443	0	28	73									
SDPR	8436	broad.mit.edu	37	2	192700978	192700978	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr2:192700978C>G	uc002utb.2	-	2	1279	c.949G>C	c.(949-951)GAC>CAC	p.D317H		NM_004657	NP_004648	O95810	SDPR_HUMAN	serum deprivation response protein	317						caveola|cytosol	phosphatidylserine binding|protein binding			ovary(1)|pancreas(1)	2			OV - Ovarian serous cystadenocarcinoma(117;0.0647)		Phosphatidylserine(DB00144)	CTAGGCAGGTCTTCTGACTTG	0.552		NaN											0	0	0	0.01441	0	74	127									
SDPR	8436	broad.mit.edu	37	2	192701111	192701111	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr2:192701111C>G	uc002utb.2	-	2	1146	c.816G>C	c.(814-816)AAG>AAC	p.K272N		NM_004657	NP_004648	O95810	SDPR_HUMAN	serum deprivation response protein	272						caveola|cytosol	phosphatidylserine binding|protein binding			ovary(1)|pancreas(1)	2			OV - Ovarian serous cystadenocarcinoma(117;0.0647)		Phosphatidylserine(DB00144)	TGAGAGATTTCTTAATCTTCT	0.458		NaN											0	0	0	0.01441	0	174	332									
PGAP1	80055	broad.mit.edu	37	2	197791211	197791211	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr2:197791211C>T	uc002utw.2	-	1	244	c.130G>A	c.(130-132)GAG>AAG	p.E44K	PGAP1_uc002utx.2_5'UTR|PGAP1_uc002uty.1_Missense_Mutation_p.E44K|PGAP1_uc010zgv.1_Intron|PGAP1_uc010fsj.2_Intron	NM_024989	NP_079265	Q75T13	PGAP1_HUMAN	GPI deacylase	44	Lumenal (Potential).				attachment of GPI anchor to protein|C-terminal protein lipidation|intracellular protein transport|myo-inositol transport	integral to membrane|intrinsic to endoplasmic reticulum membrane	nuclease activity|phosphoric ester hydrolase activity			ovary(3)|central_nervous_system(1)	4						TCCGGGTACTCAAACATGTAG	0.547		NaN											0	0	0	0.01441	0	179	145									
MOBKL3	25843	broad.mit.edu	37	2	198380840	198380840	+	Silent	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr2:198380840G>A	uc002uun.3	+	1	70	c.30G>A	c.(28-30)CTG>CTA	p.L10L	MOBKL3_uc002uum.3_Intron|MOBKL3_uc010fsn.2_Silent_p.L10L|MOBKL3_uc010fso.2_5'UTR|MOBKL3_uc010zgz.1_5'UTR	NM_015387	NP_056202	Q9Y3A3	MOBL3_HUMAN	Mps One Binder kinase activator-like 3 isoform	10					transport	Golgi cisterna membrane|perinuclear region of cytoplasm	metal ion binding|protein binding				0			Epithelial(96;0.225)			CGGCAGTGCTGAGGCGGAACA	0.687		NaN											0	0	0	0.009096	0	4	6									
C2orf69	205327	broad.mit.edu	37	2	200790122	200790122	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr2:200790122C>G	uc010zhb.1	+	2	854	c.671C>G	c.(670-672)TCT>TGT	p.S224C		NM_153689	NP_710156	Q8N8R5	CB069_HUMAN	hypothetical protein LOC205327 precursor	224						extracellular region				central_nervous_system(1)	1						TCCAGTCCTTCTCATACTACG	0.363		NaN											0	0	0	0.007835	0	43	71									
RAPH1	65059	broad.mit.edu	37	2	204324748	204324748	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr2:204324748C>G	uc002vad.2	-	7	1199	c.974G>C	c.(973-975)AGA>ACA	p.R325T	RAPH1_uc002vae.2_Missense_Mutation_p.R377T|RAPH1_uc002vaf.2_Missense_Mutation_p.R377T	NM_213589	NP_998754	Q70E73	RAPH1_HUMAN	Ras association and pleckstrin homology domains	325	Ras-associating.				cell-matrix adhesion|signal transduction	cytoplasm|cytoskeleton|filopodium|lamellipodium|nucleus|plasma membrane				ovary(3)|breast(3)|central_nervous_system(2)|lung(1)|skin(1)	10						TTCAAAGATTCTCTCTGTCCC	0.318		NaN											0	0	0	0.003271	0	34	69									
PLEKHM3	389072	broad.mit.edu	37	2	208795688	208795688	+	Silent	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr2:208795688G>A	uc002vcl.2	-	5	2338	c.1848C>T	c.(1846-1848)TTC>TTT	p.F616F	PLEKHM3_uc002vcm.2_Silent_p.F616F	NM_001080475	NP_001073944	Q6ZWE6	PKHM3_HUMAN	pleckstrin homology domain containing, family M,	616					intracellular signal transduction		metal ion binding			ovary(1)	1						CCCGGCAGCTGAACAAATAGG	0.627		NaN											0	0	0	0.011902	0	22	20									
PLCD4	84812	broad.mit.edu	37	2	219498429	219498429	+	Silent	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr2:219498429C>T	uc002vij.1	+	11	1746	c.1551C>T	c.(1549-1551)TTC>TTT	p.F517F	PLCD4_uc010zkk.1_Silent_p.F67F	NM_032726	NP_116115	Q9BRC7	PLCD4_HUMAN	phospholipase C, delta 4	517	PI-PLC Y-box.				intracellular signal transduction|lipid catabolic process	endoplasmic reticulum|membrane|nucleus	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			ovary(3)	3		Renal(207;0.0915)		Epithelial(149;5.11e-07)|all cancers(144;0.000104)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)		ACTACCACTTCTACGAGATAT	0.502		NaN											0	0	0	0.006122	0	19	59									
RNF25	64320	broad.mit.edu	37	2	219528996	219528996	+	Missense_Mutation	SNP	G	G	C	rs146227317		TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr2:219528996G>C	uc002vit.2	-	10	1152	c.1064C>G	c.(1063-1065)CCA>CGA	p.P355R	RNF25_uc010fvw.2_Missense_Mutation_p.P243R	NM_022453	NP_071898	Q96BH1	RNF25_HUMAN	ring finger protein 25	355					positive regulation of NF-kappaB transcription factor activity	cytosol|nucleus	NF-kappaB binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2		Renal(207;0.0474)		Epithelial(149;6.99e-07)|all cancers(144;0.000129)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		CCCTCCCTTTGGGTGCCTCCG	0.612		NaN											0	0	0	0.004878	0	37	137									
DNER	92737	broad.mit.edu	37	2	230341868	230341868	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr2:230341868G>A	uc002vpv.2	-	7	1396	c.1249C>T	c.(1249-1251)CAG>TAG	p.Q417*	DNER_uc010zly.1_Nonsense_Mutation_p.Q145*	NM_139072	NP_620711	Q8NFT8	DNER_HUMAN	delta-notch-like EGF repeat-containing	417	Extracellular (Potential).|EGF-like 5.				central nervous system development|endocytosis|neuron migration|Notch signaling pathway|synapse assembly	dendrite|early endosome|integral to membrane|plasma membrane	calcium ion binding|clathrin binding|transmembrane receptor activity			lung(5)|ovary(2)|skin(1)	8		all_lung(227;0.00413)|Renal(207;0.0113)|Lung NSC(271;0.0211)|all_hematologic(139;0.105)|Acute lymphoblastic leukemia(138;0.175)		Epithelial(121;1.4e-11)|all cancers(144;7.7e-09)|LUSC - Lung squamous cell carcinoma(224;0.034)|Lung(119;0.0375)		TCTGGACACTGGCAGGTGAAT	0.368		NaN											0	0	0	0.005524	0	38	21									
NEU2	4759	broad.mit.edu	37	2	233899630	233899630	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr2:233899630G>A	uc010zmn.1	+	2	1006	c.1006G>A	c.(1006-1008)GAC>AAC	p.D336N		NM_005383	NP_005374	Q9Y3R4	NEUR2_HUMAN	neuraminidase 2	336							exo-alpha-sialidase activity				0		Breast(86;0.00279)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0271)|Acute lymphoblastic leukemia(138;0.0326)|Lung NSC(271;0.0839)		Epithelial(121;7.17e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000311)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.00942)|GBM - Glioblastoma multiforme(43;0.0488)		TGCCTACTCAGACCTCCAGAG	0.612		NaN											0	0	0	0.01441	0	114	84									
COL6A3	1293	broad.mit.edu	37	2	238266512	238266512	+	Missense_Mutation	SNP	T	T	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr2:238266512T>A	uc002vwl.2	-	22	6770	c.6485A>T	c.(6484-6486)CAA>CTA	p.Q2162L	COL6A3_uc002vwo.2_Missense_Mutation_p.Q1956L|COL6A3_uc010znj.1_Missense_Mutation_p.Q1555L|COL6A3_uc002vwp.1_5'Flank	NM_004369	NP_004360	P12111	CO6A3_HUMAN	alpha 3 type VI collagen isoform 1 precursor	2162	Triple-helical region.|Collagen-like 2.				axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			ovary(8)|central_nervous_system(6)|skin(2)|upper_aerodigestive_tract(1)|pancreas(1)	18		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		CTGGCTGTCTTGTCCTGGGTT	0.527		NaN											0	0	0	0.01441	0	166	123									
HDAC4	9759	broad.mit.edu	37	2	240111708	240111708	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr2:240111708C>T	uc002vyk.3	-	4	952	c.160G>A	c.(160-162)GAC>AAC	p.D54N	HDAC4_uc010fyz.1_Missense_Mutation_p.D49N|HDAC4_uc010zoa.1_Missense_Mutation_p.D49N|HDAC4_uc010fza.2_Missense_Mutation_p.D54N|HDAC4_uc002vyl.1_RNA|HDAC4_uc010fyy.2_Missense_Mutation_p.D6N	NM_006037	NP_006028	P56524	HDAC4_HUMAN	histone deacetylase 4	54					B cell differentiation|cardiac muscle hypertrophy in response to stress|chromatin remodeling|histone H3 deacetylation|histone H4 deacetylation|inflammatory response|negative regulation of glycolysis|negative regulation of myotube differentiation|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|nervous system development|peptidyl-lysine deacetylation|positive regulation of cell proliferation|positive regulation of protein sumoylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of protein binding|response to denervation involved in regulation of muscle adaptation|response to interleukin-1|transcription, DNA-dependent	histone deacetylase complex|transcriptional repressor complex	activating transcription factor binding|histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|potassium ion binding|repressing transcription factor binding|zinc ion binding			breast(3)|skin(2)|ovary(1)	6		all_epithelial(40;1.45e-17)|Breast(86;1.53e-05)|Renal(207;0.000355)|all_lung(227;0.0121)|Ovarian(221;0.0183)|Lung NSC(271;0.0413)|Melanoma(123;0.0749)|all_hematologic(139;0.159)		Epithelial(121;6.38e-25)|OV - Ovarian serous cystadenocarcinoma(60;2.48e-12)|Kidney(56;6.04e-08)|KIRC - Kidney renal clear cell carcinoma(57;1.18e-06)|BRCA - Breast invasive adenocarcinoma(100;3.99e-05)|Lung(119;0.00942)|LUSC - Lung squamous cell carcinoma(224;0.04)		AACTGGTGGTCCAGGCGCAGG	0.657		NaN											0	0	0	0.007413	0	18	9									
ATG4B	23192	broad.mit.edu	37	2	242598539	242598539	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr2:242598539G>A	uc002wbv.2	+	7	578	c.475G>A	c.(475-477)GAT>AAT	p.D159N	ATG4B_uc002wbu.2_Missense_Mutation_p.D85N|ATG4B_uc002wbw.2_Missense_Mutation_p.D159N|ATG4B_uc010zox.1_Missense_Mutation_p.D145N|ATG4B_uc010zoy.1_Missense_Mutation_p.D85N|ATG4B_uc010fzp.2_Missense_Mutation_p.D159N|ATG4B_uc010zoz.1_Missense_Mutation_p.D85N	NM_013325	NP_037457	Q9Y4P1	ATG4B_HUMAN	APG4 autophagy 4 homolog B isoform a	159					autophagic vacuole assembly|protein transport|proteolysis	cytoplasm	cysteine-type peptidase activity|protein binding				0		all_cancers(19;1.09e-40)|all_epithelial(40;2.03e-18)|Breast(86;1.53e-05)|all_lung(227;0.00338)|Renal(207;0.00502)|Ovarian(221;0.00716)|Lung NSC(271;0.012)|Esophageal squamous(248;0.129)|Melanoma(123;0.144)|all_hematologic(139;0.158)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;2.44e-33)|all cancers(36;5.71e-31)|OV - Ovarian serous cystadenocarcinoma(60;3.75e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;1.65e-06)|Lung(119;0.000152)|LUSC - Lung squamous cell carcinoma(224;0.00154)|Colorectal(34;0.0129)|COAD - Colon adenocarcinoma(134;0.0848)		TGCTGTCTTCGATACGTGGAG	0.468		NaN											0	0	0	0.001168	0	6	41									
NOP56	10528	broad.mit.edu	37	20	2636004	2636004	+	Silent	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr20:2636004G>A	uc002wgh.2	+	6	656	c.603G>A	c.(601-603)GTG>GTA	p.V201V	NOP56_uc010zpy.1_RNA|NOP56_uc002wgi.2_Silent_p.V35V|NOP56_uc002wgm.1_5'Flank|SNORD86_uc010gaq.1_5'Flank|SNORD56_uc010gar.2_5'Flank|SNORD57_uc002wgo.1_5'Flank	NM_006392	NP_006383	O00567	NOP56_HUMAN	nucleolar protein 5A	201					rRNA processing	box C/D snoRNP complex|pre-snoRNP complex	protein binding|snoRNA binding			ovary(1)|pancreas(1)	2						CGGAGCTGGTGAAGATCATCA	0.522		NaN											0	0	0	0.004007	0	15	83									
PLCB1	23236	broad.mit.edu	37	20	8113380	8113380	+	Missense_Mutation	SNP	T	T	C			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr20:8113380T>C	uc002wnb.2	+	1	85	c.82T>C	c.(82-84)TTC>CTC	p.F28L	PLCB1_uc010zrb.1_Intron|PLCB1_uc010gbv.1_Missense_Mutation_p.F28L|PLCB1_uc002wmz.1_Missense_Mutation_p.F28L|PLCB1_uc002wna.2_Missense_Mutation_p.F28L	NM_015192	NP_056007	Q9NQ66	PLCB1_HUMAN	phosphoinositide-specific phospholipase C beta 1	28				MAGAQPGVHALQLKPVCVSDSLKKGTKFVKWDDD -> MGS LQGIATKILIRILSDALIRKETDLKS (in Ref. 2; AAF86613).	activation of meiosis involved in egg activation|CD24 biosynthetic process|cerebral cortex development|G1 phase|G2/M transition of mitotic cell cycle|glutamate signaling pathway|insulin-like growth factor receptor signaling pathway|interleukin-1-mediated signaling pathway|interleukin-12-mediated signaling pathway|interleukin-15-mediated signaling pathway|intracellular signal transduction|lipid catabolic process|memory|muscarinic acetylcholine receptor signaling pathway|negative regulation of monocyte extravasation|negative regulation of transcription, DNA-dependent|phosphatidylinositol metabolic process|positive regulation of acrosome reaction|positive regulation of developmental growth|positive regulation of embryonic development|positive regulation of interleukin-12 production|positive regulation of JNK cascade|positive regulation of myoblast differentiation|positive regulation of transcription, DNA-dependent|regulation of fertilization|regulation of G-protein coupled receptor protein signaling pathway|synaptic transmission	cytosol|nuclear chromatin|nuclear speck	calcium ion binding|calmodulin binding|enzyme binding|GTPase activator activity|phosphatidylinositol phospholipase C activity|phosphatidylinositol-4,5-bisphosphate binding|protein homodimerization activity|signal transducer activity			ovary(4)|breast(3)|upper_aerodigestive_tract(2)|skin(2)|lung(1)	12						GGGCACCAAATTCGTCAAGTG	0.682		NaN											0	0	0	0.001168	0	5	5									
TPX2	22974	broad.mit.edu	37	20	30385318	30385318	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr20:30385318G>A	uc002wwp.1	+	16	2643	c.1945G>A	c.(1945-1947)GAG>AAG	p.E649K	TPX2_uc010gdv.1_Missense_Mutation_p.E685K	NM_012112	NP_036244	Q9ULW0	TPX2_HUMAN	TPX2, microtubule-associated protein homolog	649					activation of protein kinase activity|apoptosis|cell division|cell proliferation|mitosis|regulation of mitotic spindle organization	cytoplasm|microtubule|nucleus|spindle pole	ATP binding|GTP binding|protein kinase binding			large_intestine(1)|ovary(1)	2			Epithelial(4;0.000771)|Colorectal(19;0.00306)|all cancers(5;0.004)|COAD - Colon adenocarcinoma(19;0.0347)|OV - Ovarian serous cystadenocarcinoma(3;0.0656)			ATCAGTTGCTGGTAGTATTAT	0.463		NaN											0	0	0	0.010818	0	32	121									
FOXS1	2307	broad.mit.edu	37	20	30433105	30433105	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr20:30433105G>A	uc002wwt.1	-	1	316	c.241C>T	c.(241-243)CGC>TGC	p.R81C		NM_004118	NP_004109	O43638	FOXS1_HUMAN	forkhead box S1	81	Fork-head.				anti-apoptosis|artery morphogenesis|blood vessel remodeling|camera-type eye development|cardiac muscle cell proliferation|collagen fibril organization|embryonic heart tube development|insulin receptor signaling pathway|lymphangiogenesis|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription, DNA-dependent|neural crest cell fate commitment|neuromuscular process controlling balance|Notch signaling pathway|ossification|paraxial mesodermal cell fate commitment|patterning of blood vessels|positive regulation of multicellular organism growth|positive regulation of transcription from RNA polymerase II promoter|regulation of blood vessel size|regulation of organ growth|somitogenesis|vascular endothelial growth factor receptor signaling pathway|vasculogenesis|ventricular cardiac muscle tissue morphogenesis	transcription factor complex	chromatin DNA binding|DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			ovary(1)	1						CGGTCATCGCGGGGCACCTTG	0.637		NaN											0	0	0	0.003163	0	14	23									
DNMT3B	1789	broad.mit.edu	37	20	31376814	31376814	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr20:31376814C>G	uc002wyc.2	+	7	1130	c.809C>G	c.(808-810)TCC>TGC	p.S270C	DNMT3B_uc010ztx.1_RNA|DNMT3B_uc010zty.1_RNA|DNMT3B_uc002wyd.2_Missense_Mutation_p.S270C|DNMT3B_uc002wye.2_Missense_Mutation_p.S270C|DNMT3B_uc010gee.2_RNA|DNMT3B_uc010gef.2_RNA|DNMT3B_uc010ztz.1_Missense_Mutation_p.S228C|DNMT3B_uc010zua.1_Missense_Mutation_p.S194C|DNMT3B_uc002wyf.2_Missense_Mutation_p.S282C|DNMT3B_uc002wyg.2_5'Flank	NM_006892	NP_008823	Q9UBC3	DNM3B_HUMAN	DNA cytosine-5 methyltransferase 3 beta isoform	270	PWWP.|Interaction with DNMT1 and DNMT3A.		S -> P (in ICF).		negative regulation of histone H3-K9 methylation|positive regulation of gene expression|positive regulation of histone H3-K4 methylation		metal ion binding|protein binding|transcription corepressor activity			lung(3)|ovary(2)	5						GGCAAGTTCTCCGAGGTGAGT	0.607		NaN											0	0	0	0.010504	0	20	25									
RALY	22913	broad.mit.edu	37	20	32659982	32659982	+	Missense_Mutation	SNP	G	G	C	rs114080584	by1000genomes	TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr20:32659982G>C	uc002xab.2	+	3	400	c.102G>C	c.(100-102)AAG>AAC	p.K34N	RALY_uc010zui.1_Missense_Mutation_p.K34N|RALY_uc002xac.2_Missense_Mutation_p.K34N|RALY_uc002xad.2_RNA|RALY_uc002xae.1_Missense_Mutation_p.K34N	NM_016732	NP_057951	Q9UKM9	RALY_HUMAN	RNA binding protein (autoantigenic,	34	RRM.					catalytic step 2 spliceosome|heterogeneous nuclear ribonucleoprotein complex	nucleotide binding|RNA binding			ovary(1)	1						CTCTGGTGAAGAAATCAGATG	0.488		NaN											0	0	0	0.010504	0	21	114									
RALY	22913	broad.mit.edu	37	20	32664519	32664519	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr20:32664519G>A	uc002xab.2	+	7	854	c.556G>A	c.(556-558)GAG>AAG	p.E186K	RALY_uc002xac.2_Missense_Mutation_p.E170K|RALY_uc002xad.2_RNA|RALY_uc002xae.1_Missense_Mutation_p.E186K	NM_016732	NP_057951	Q9UKM9	RALY_HUMAN	RNA binding protein (autoantigenic,	186						catalytic step 2 spliceosome|heterogeneous nuclear ribonucleoprotein complex	nucleotide binding|RNA binding			ovary(1)	1						AAAGAGCAGTGAGCTGCAGGC	0.572		NaN											0	0	0	0.006214	0	8	45									
EPB41L1	2036	broad.mit.edu	37	20	34782172	34782172	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr20:34782172G>A	uc002xfb.2	+	12	1510	c.1339G>A	c.(1339-1341)GAT>AAT	p.D447N	EPB41L1_uc002xeu.2_Missense_Mutation_p.D385N|EPB41L1_uc010zvo.1_Missense_Mutation_p.D447N|EPB41L1_uc002xev.2_Missense_Mutation_p.D447N|EPB41L1_uc002xew.2_Missense_Mutation_p.D350N|EPB41L1_uc002xex.2_Missense_Mutation_p.D416N|EPB41L1_uc002xey.2_Missense_Mutation_p.D374N|EPB41L1_uc002xez.2_Missense_Mutation_p.D385N	NM_012156	NP_036288	Q9H4G0	E41L1_HUMAN	erythrocyte membrane protein band 4.1-like 1	447					cortical actin cytoskeleton organization|synaptic transmission	cytoskeleton|cytosol|extrinsic to membrane|plasma membrane	actin binding|structural molecule activity			ovary(2)|pancreas(1)	3	Breast(12;0.0239)					CGAGAACCATGATGCAGGGCC	0.597		NaN											0	0	0	0.00308	0	6	28									
DHX35	60625	broad.mit.edu	37	20	37621005	37621005	+	Silent	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr20:37621005C>T	uc002xjh.2	+	7	530	c.519C>T	c.(517-519)ATC>ATT	p.I173I	DHX35_uc010zwa.1_Silent_p.I18I|DHX35_uc010zwb.1_Silent_p.I18I|DHX35_uc010zwc.1_Silent_p.I142I	NM_021931	NP_068750	Q9H5Z1	DHX35_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 35	173	Helicase ATP-binding.					catalytic step 2 spliceosome	ATP binding|ATP-dependent helicase activity|nucleic acid binding			lung(1)|kidney(1)|skin(1)	3		Myeloproliferative disorder(115;0.00878)				TTAGTGTCATCATGCTGGATG	0.433		NaN											0	0	0	0.01441	0	49	126									
CHD6	84181	broad.mit.edu	37	20	40065975	40065975	+	Splice_Site	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr20:40065975C>T	uc002xka.1	-	27	4186	c.4008_splice	c.e27-1	p.R1336_splice	CHD6_uc002xkb.1_Intron	NM_032221	NP_115597	Q8TD26	CHD6_HUMAN	chromodomain helicase DNA binding protein 6						chromatin remodeling|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding			ovary(6)|skin(5)|lung(2)|central_nervous_system(1)	14		Myeloproliferative disorder(115;0.00425)				TGTGTTGCCTCTAAATAAAAG	0.264		NaN											0	0	0	0.00623	0	41	84									
SGK2	10110	broad.mit.edu	37	20	42196637	42196637	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr20:42196637G>C	uc002xkv.2	+	4	625	c.406G>C	c.(406-408)GAG>CAG	p.E136Q	SGK2_uc002xkt.2_RNA|SGK2_uc002xkr.2_Missense_Mutation_p.E76Q|SGK2_uc010ggm.2_Missense_Mutation_p.E76Q|SGK2_uc002xks.2_Missense_Mutation_p.E76Q|SGK2_uc002xku.2_Missense_Mutation_p.E76Q|SGK2_uc002xkq.1_Missense_Mutation_p.E76Q	NM_016276	NP_057360	Q9HBY8	SGK2_HUMAN	serum/glucocorticoid regulated kinase 2 isoform	136	Protein kinase.|Nuclear localization signal (By similarity).				intracellular protein kinase cascade|response to oxidative stress		ATP binding|potassium channel regulator activity|protein serine/threonine kinase activity|sodium channel regulator activity			lung(3)|upper_aerodigestive_tract(1)|breast(1)|central_nervous_system(1)	6		Myeloproliferative disorder(115;0.00452)	COAD - Colon adenocarcinoma(18;0.0031)			AAAGAAGAAAGAGGTACCAGA	0.502		NaN											0	0	0	0.008291	0	9	59									
SERINC3	10955	broad.mit.edu	37	20	43141486	43141486	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr20:43141486G>C	uc002xme.2	-	3	485	c.351C>G	c.(349-351)TTC>TTG	p.F117L	SERINC3_uc002xmf.1_Missense_Mutation_p.F117L|SERINC3_uc010ggs.1_Missense_Mutation_p.F110L|SERINC3_uc010zwp.1_Missense_Mutation_p.F62L	NM_198941	NP_945179	Q13530	SERC3_HUMAN	tumor differentially expressed protein 1	117	Helical; (Potential).					integral to membrane|plasma membrane	protein binding			skin(3)	3		Myeloproliferative disorder(115;0.0122)	Colorectal(3;0.000291)|COAD - Colon adenocarcinoma(18;0.00189)			TTTTTACTTTGAACATGAGCA	0.398		NaN											0	0	0	0.004007	0	17	108									
PKIG	11142	broad.mit.edu	37	20	43243233	43243233	+	Silent	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr20:43243233C>T	uc002xmg.2	+	5	565	c.36C>T	c.(34-36)ATC>ATT	p.I12I	PKIG_uc002xmh.2_Silent_p.I12I|PKIG_uc002xmi.2_Silent_p.I12I	NM_181805	NP_861521	Q9Y2B9	IPKG_HUMAN	cAMP-dependent protein kinase inhibitor gamma	12							cAMP-dependent protein kinase inhibitor activity|protein binding				0		Myeloproliferative disorder(115;0.0122)	Colorectal(3;0.001)|COAD - Colon adenocarcinoma(18;0.00189)			CGGACTTCATCTCCTGTGACC	0.617		NaN											0	0	0	0.008361	0	31	74									
RIMS4	140730	broad.mit.edu	37	20	43399923	43399923	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr20:43399923C>G	uc002xms.2	-	2	229	c.229G>C	c.(229-231)GAG>CAG	p.E77Q	RIMS4_uc010ggu.2_Missense_Mutation_p.E78Q	NM_182970	NP_892015	Q9H426	RIMS4_HUMAN	regulating synaptic membrane exocytosis 4	77					exocytosis|neurotransmitter transport	cell junction|synapse				ovary(4)|central_nervous_system(1)	5		Myeloproliferative disorder(115;0.0122)				TACTTGCCCTCTGAGCCATAG	0.637		NaN											0	0	0	0.003163	0	15	67									
ZMYND8	23613	broad.mit.edu	37	20	45923508	45923508	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr20:45923508C>T	uc002xta.1	-	5	663	c.409G>A	c.(409-411)GAA>AAA	p.E137K	ZMYND8_uc010ghr.1_Missense_Mutation_p.E112K|ZMYND8_uc002xst.1_Missense_Mutation_p.E112K|ZMYND8_uc002xsu.1_Missense_Mutation_p.E137K|ZMYND8_uc002xsv.1_Missense_Mutation_p.E112K|ZMYND8_uc002xsw.1_5'UTR|ZMYND8_uc002xsx.1_5'UTR|ZMYND8_uc002xsy.1_Missense_Mutation_p.E112K|ZMYND8_uc002xsz.1_Intron|ZMYND8_uc010zxy.1_Missense_Mutation_p.E164K|ZMYND8_uc002xtb.1_Missense_Mutation_p.E157K|ZMYND8_uc002xss.2_Missense_Mutation_p.E137K|ZMYND8_uc010zxz.1_Missense_Mutation_p.E132K|ZMYND8_uc002xtc.1_Missense_Mutation_p.E157K|ZMYND8_uc002xtd.1_Missense_Mutation_p.E132K|ZMYND8_uc002xte.1_Missense_Mutation_p.E137K|ZMYND8_uc010zya.1_Missense_Mutation_p.E137K|ZMYND8_uc002xtf.1_Missense_Mutation_p.E157K|ZMYND8_uc002xtg.2_Missense_Mutation_p.E131K|ZMYND8_uc010ghs.1_Missense_Mutation_p.E131K	NM_012408	NP_036540	Q9ULU4	PKCB1_HUMAN	zinc finger, MYND-type containing 8 isoform b	137							protein binding|zinc ion binding			central_nervous_system(2)|urinary_tract(1)|ovary(1)|skin(1)	5			Epithelial(1;0.0289)|all cancers(1;0.0962)|OV - Ovarian serous cystadenocarcinoma(1;0.154)			TCGATGCATTCTGCTACTGTA	0.383		NaN											0	0	0	0.01441	0	92	227									
CSE1L	1434	broad.mit.edu	37	20	47704592	47704592	+	Silent	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr20:47704592C>T	uc002xty.2	+	17	1904	c.1770C>T	c.(1768-1770)TAC>TAT	p.Y590Y	CSE1L_uc010zyg.1_Silent_p.Y373Y|CSE1L_uc010ghx.2_Silent_p.Y534Y|CSE1L_uc010ghy.2_Silent_p.Y211Y|CSE1L_uc010zyh.1_Silent_p.Y239Y	NM_001316	NP_001307	P55060	XPO2_HUMAN	CSE1 chromosome segregation 1-like protein	590					apoptosis|cell proliferation|intracellular protein transport	cytoplasm|nucleus	importin-alpha export receptor activity			large_intestine(1)|skin(1)	2			BRCA - Breast invasive adenocarcinoma(12;0.000491)|Colorectal(8;0.198)			TAATCCCCTACATCCCTACTC	0.348		NaN											0	0	0	0.006999	0	36	106									
SLC9A8	23315	broad.mit.edu	37	20	48503324	48503324	+	Silent	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr20:48503324C>T	uc002xuv.1	+	15	1737	c.1527C>T	c.(1525-1527)CTC>CTT	p.L509L	SLC9A8_uc010zym.1_Silent_p.L209L|SLC9A8_uc010gid.2_Silent_p.L133L	NM_015266	NP_056081	Q9Y2E8	SL9A8_HUMAN	sodium/hydrogen exchanger 8	509						Golgi membrane|integral to membrane	sodium:hydrogen antiporter activity			ovary(1)	1			BRCA - Breast invasive adenocarcinoma(9;3.91e-07)			TGTCGGAGCTCACGGAGGAGG	0.647		NaN											0	0	0	0.004656	0	23	61									
ATP9A	10079	broad.mit.edu	37	20	50255994	50255994	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr20:50255994C>T	uc002xwg.1	-	15	1556	c.1556G>A	c.(1555-1557)CGA>CAA	p.R519Q	ATP9A_uc010gih.1_Missense_Mutation_p.R383Q|ATP9A_uc002xwf.1_Intron	NM_006045	NP_006036	O75110	ATP9A_HUMAN	ATPase, class II, type 9A	519	Cytoplasmic (Potential).				ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(4)	4						AGACTGGTCTCGGCCCACCAG	0.547		NaN									OREG0026043	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.00632	0	29	88									
TSHZ2	128553	broad.mit.edu	37	20	51871960	51871960	+	Nonsense_Mutation	SNP	G	G	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr20:51871960G>T	uc002xwo.2	+	2	2919	c.1963G>T	c.(1963-1965)GAG>TAG	p.E655*		NM_173485	NP_775756	Q9NRE2	TSH2_HUMAN	teashirt zinc finger homeobox 2	655					multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(5)|haematopoietic_and_lymphoid_tissue(1)	6			STAD - Stomach adenocarcinoma(23;0.1)			GAAGGAGGAGGAGAAGCTGAT	0.592		NaN											1	0	3.09899e-07	0.004482	3.18577e-07	9	69									
GNAS	2778	broad.mit.edu	37	20	57480468	57480468	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr20:57480468G>C	uc002xzw.2	+	6	2677	c.2392G>C	c.(2392-2394)GAG>CAG	p.E798Q	GNAS_uc002xzt.2_3'UTR|GNAS_uc010gjq.2_Missense_Mutation_p.E96Q|GNAS_uc002xzx.2_Missense_Mutation_p.E96Q|GNAS_uc010gjr.2_Missense_Mutation_p.E46Q|GNAS_uc002xzy.2_Missense_Mutation_p.E81Q|GNAS_uc002yaa.2_Missense_Mutation_p.E141Q|GNAS_uc010zzt.1_Missense_Mutation_p.E156Q|GNAS_uc002yab.2_Intron|GNAS_uc002yad.2_Missense_Mutation_p.E46Q|GNAS_uc002yae.2_Missense_Mutation_p.E80Q	NM_080425	NP_536350	P63092	GNAS2_HUMAN	GNAS complex locus XLas	155					activation of adenylate cyclase activity|cellular response to glucagon stimulus|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|intracellular transport|platelet activation|regulation of insulin secretion|sensory perception of smell|transmembrane transport|water transport	heterotrimeric G-protein complex|intrinsic to membrane|trans-Golgi network membrane	adenylate cyclase activity|GTP binding|GTPase activity|guanyl-nucleotide exchange factor activity|identical protein binding|signal transducer activity			pituitary(201)|thyroid(35)|ovary(15)|adrenal_gland(9)|liver(7)|large_intestine(5)|parathyroid(5)|kidney(5)|haematopoietic_and_lymphoid_tissue(3)|lung(2)|testis(1)|stomach(1)|small_intestine(1)|autonomic_ganglia(1)|pancreas(1)	292	all_lung(29;0.0104)		BRCA - Breast invasive adenocarcinoma(13;2.19e-08)|Colorectal(105;0.109)			GGCTCTGTGGGAGGATGAAGG	0.473		NaN	Mis		pituitary adenoma		McCune-Albright syndrome; pseudohypoparathyroidism|type IA		3-Methylglutaconic_Aciduria_and_Myelodysplasia|McCune-Albright_syndrome|Mazabraud_syndrome	TSP Lung(22;0.16)			0	0	0	0.006214	0	8	64									
PRIC285	85441	broad.mit.edu	37	20	62195447	62195447	+	Silent	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr20:62195447C>T	uc002yfm.2	-	9	5620	c.4728G>A	c.(4726-4728)CTG>CTA	p.L1576L	PRIC285_uc002yfl.1_Silent_p.L1007L	NM_001037335	NP_001032412	Q9BYK8	PR285_HUMAN	PPAR-alpha interacting complex protein 285	1576					cellular lipid metabolic process|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm	ATP binding|DNA binding|helicase activity|ribonuclease activity|RNA binding|transcription coactivator activity|zinc ion binding			central_nervous_system(2)	2	all_cancers(38;2.51e-11)|all_epithelial(29;8.27e-13)		Epithelial(9;1.27e-08)|all cancers(9;7.32e-08)|BRCA - Breast invasive adenocarcinoma(10;5.15e-06)			GGTGCAGTGACAGGGGCACCC	0.711		NaN											0	0	0	0.010729	0	10	16									
MYT1	4661	broad.mit.edu	37	20	62838960	62838960	+	Silent	SNP	C	C	G			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr20:62838960C>G	uc002yii.2	+	7	775	c.411C>G	c.(409-411)GTC>GTG	p.V137V	MYT1_uc002yih.2_Intron|MYT1_uc002yij.2_5'UTR	NM_004535	NP_004526	Q01538	MYT1_HUMAN	myelin transcription factor 1	137					cell differentiation|nervous system development	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2	all_cancers(38;1.82e-11)|all_epithelial(29;3.3e-13)|Lung NSC(23;5.21e-10)|all_lung(23;1.92e-09)					GGAGCCCCGTCAAGTCCCATT	0.582		NaN											0	0	0	0.008871	0	18	117									
SFRS15	57466	broad.mit.edu	37	21	33044531	33044531	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr21:33044531C>G	uc002ypd.2	-	20	3051	c.2625G>C	c.(2623-2625)TTG>TTC	p.L875F	SFRS15_uc002ype.2_Missense_Mutation_p.L853F|SFRS15_uc010glu.2_Missense_Mutation_p.L860F	NM_020706	NP_065757	O95104	SFR15_HUMAN	splicing factor, arginine/serine-rich 15 isoform	875						nucleus	nucleotide binding|RNA binding				0						GGGGCGGCATCAAAGGGAACC	0.632		NaN											0	0	0	0.014323	0	22	73									
ITSN1	6453	broad.mit.edu	37	21	35153820	35153820	+	Missense_Mutation	SNP	A	A	G			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr21:35153820A>G	uc002yta.1	+	15	1920	c.1652A>G	c.(1651-1653)CAA>CGA	p.Q551R	DONSON_uc002ysn.1_Intron|ITSN1_uc002yth.3_RNA|ITSN1_uc002ysz.2_Missense_Mutation_p.Q551R|ITSN1_uc010gmg.2_Missense_Mutation_p.Q514R|ITSN1_uc010gmh.2_RNA|ITSN1_uc002ysw.2_Missense_Mutation_p.Q551R|ITSN1_uc010gmi.2_Missense_Mutation_p.Q514R|ITSN1_uc010gmj.2_Missense_Mutation_p.Q435R|ITSN1_uc002ysy.2_Missense_Mutation_p.Q551R|ITSN1_uc002ysx.2_Missense_Mutation_p.Q514R|ITSN1_uc002ytb.1_Missense_Mutation_p.Q551R|ITSN1_uc002ytc.1_Missense_Mutation_p.Q551R|ITSN1_uc002ytd.2_RNA|ITSN1_uc010gmk.2_Missense_Mutation_p.Q514R|ITSN1_uc010gml.2_RNA|ITSN1_uc002ytj.2_Missense_Mutation_p.Q551R|ITSN1_uc010gmm.1_RNA|ITSN1_uc002yte.2_Missense_Mutation_p.Q485R	NM_003024	NP_003015	Q15811	ITSN1_HUMAN	intersectin 1 isoform ITSN-l	551	Potential.|KLERQ.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|synaptic vesicle endocytosis	cell junction|coated pit|cytosol|lamellipodium|synapse|synaptosome	calcium ion binding|proline-rich region binding|protein complex scaffold|Rho guanyl-nucleotide exchange factor activity			ovary(3)|skin(1)	4						CTCAATGACCAATTAAAACAA	0.299		NaN											0	0	0	0.006122	0	15	122									
MORC3	23515	broad.mit.edu	37	21	37741509	37741509	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr21:37741509G>A	uc002yvi.2	+	15	1919	c.1843G>A	c.(1843-1845)GAC>AAC	p.D615N		NM_015358	NP_056173	Q14149	MORC3_HUMAN	MORC family CW-type zinc finger 3	615					cell aging|maintenance of protein location in nucleus|negative regulation of fibroblast proliferation|peptidyl-serine phosphorylation|protein stabilization	aggresome|intermediate filament cytoskeleton|PML body	ATP binding|zinc ion binding			ovary(2)	2						GTTTGTGGGTGACAGTGAACC	0.473		NaN											0	0	0	0.01441	0	70	130									
TTC3	7267	broad.mit.edu	37	21	38519889	38519889	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr21:38519889G>A	uc002yvz.2	+	22	2107	c.2002G>A	c.(2002-2004)GAT>AAT	p.D668N	TTC3_uc011aee.1_Missense_Mutation_p.D358N|TTC3_uc002ywa.2_Missense_Mutation_p.D668N|TTC3_uc002ywb.2_Missense_Mutation_p.D668N|TTC3_uc010gnf.2_Missense_Mutation_p.D433N|TTC3_uc002ywc.2_Missense_Mutation_p.D358N|TTC3_uc011aed.1_Missense_Mutation_p.D358N	NM_001001894	NP_001001894	P53804	TTC3_HUMAN	tetratricopeptide repeat domain 3	668					protein K48-linked ubiquitination|ubiquitin-dependent protein catabolic process	nucleus	protein binding|ubiquitin-protein ligase activity|zinc ion binding			skin(3)|ovary(2)|lung(2)|breast(2)	9		Myeloproliferative disorder(46;0.0412)				ATACATAACTGATCCAGACTT	0.378		NaN											0	0	0	0.01441	0	58	179									
ERG	2078	broad.mit.edu	37	21	39755527	39755527	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr21:39755527G>A	uc010gnw.2	-	12	1554	c.1259C>T	c.(1258-1260)TCA>TTA	p.S420L	ERG_uc002yxa.2_Missense_Mutation_p.S413L|ERG_uc011aek.1_Missense_Mutation_p.S321L|ERG_uc010gnv.2_Missense_Mutation_p.S297L|ERG_uc010gnx.2_Missense_Mutation_p.S396L|ERG_uc011ael.1_Missense_Mutation_p.S420L|ERG_uc002yxb.2_Missense_Mutation_p.S396L	NM_001136155	NP_001129627	P11308	ERG_HUMAN	ets-related isoform 4	420					cell proliferation|multicellular organismal development|protein phosphorylation	cytoplasm|nucleus|ribonucleoprotein complex	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|signal transducer activity		TMPRSS2/ERG(2499)|FUS/ERG(163)|EWSR1/ERG(162)	prostate(2499)|bone(167)|haematopoietic_and_lymphoid_tissue(153)|soft_tissue(5)|lung(2)|skin(1)|ovary(1)	2828		Prostate(19;3.6e-06)				CGGGAGGTCTGAGGGGTACTT	0.597		NaN											0	0	0	0.01441	0	62	71									
BRWD1	54014	broad.mit.edu	37	21	40559037	40559037	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr21:40559037G>A	uc002yxk.1	-	42	7017	c.6878C>T	c.(6877-6879)TCT>TTT	p.S2293F	BRWD1_uc010goc.1_Missense_Mutation_p.S936F	NM_018963	NP_061836	Q9NSI6	BRWD1_HUMAN	bromodomain and WD repeat domain containing 1	2293					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus				skin(3)|ovary(1)	4		Prostate(19;8.44e-08)|all_epithelial(19;0.223)				TTCACTTTCAGAATTTATGGT	0.343		NaN											0	0	0	0.01441	0	56	146									
PCNT	5116	broad.mit.edu	37	21	47851851	47851851	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr21:47851851G>C	uc002zji.3	+	38	8580	c.8473G>C	c.(8473-8475)GAG>CAG	p.E2825Q	PCNT_uc002zjj.2_Missense_Mutation_p.E2707Q	NM_006031	NP_006022	O95613	PCNT_HUMAN	pericentrin	2825	Potential.				cilium assembly|G2/M transition of mitotic cell cycle	cytosol|microtubule	calmodulin binding			ovary(4)|breast(2)|pancreas(2)	8	Breast(49;0.112)					GCTTGAGGCTGAGGCTCAGAA	0.572		NaN											0	0	0	0.004482	0	9	45									
BCL2L13	23786	broad.mit.edu	37	22	18209590	18209590	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr22:18209590G>C	uc002zmw.2	+	7	966	c.748G>C	c.(748-750)GAG>CAG	p.E250Q	BCL2L13_uc002zmx.2_Missense_Mutation_p.E88Q|BCL2L13_uc002zmy.2_3'UTR|BCL2L13_uc010gqy.2_Missense_Mutation_p.E88Q|BCL2L13_uc011agk.1_Missense_Mutation_p.E126Q|BCL2L13_uc010gqz.2_5'UTR|BCL2L13_uc002zmz.2_Missense_Mutation_p.E88Q|BCL2L13_uc002zna.2_5'UTR	NM_015367	NP_056182	Q9BXK5	B2L13_HUMAN	BCL2-like 13 (apoptosis facilitator)	250	A.				induction of apoptosis	integral to membrane|mitochondrial membrane|nucleus	caspase activator activity			ovary(1)|lung(1)|central_nervous_system(1)|skin(1)	4		all_epithelial(15;0.123)		Lung(27;0.199)		CTGGCAGTCTGAGAGCTTACC	0.537		NaN											0	0	0	0.00308	0	8	52									
MAPK1	5594	broad.mit.edu	37	22	22161970	22161970	+	Silent	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr22:22161970G>A	uc002zvn.2	-	2	525	c.285C>T	c.(283-285)ATC>ATT	p.I95I	MAPK1_uc002zvo.2_Silent_p.I95I|MAPK1_uc010gtk.1_Silent_p.I95I	NM_002745	NP_002736	P28482	MK01_HUMAN	mitogen-activated protein kinase 1	95	Protein kinase.				activation of MAPK activity|activation of MAPKK activity|axon guidance|cell cycle|epidermal growth factor receptor signaling pathway|ERK1 and ERK2 cascade|induction of apoptosis|innate immune response|insulin receptor signaling pathway|interspecies interaction between organisms|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|platelet activation|Ras protein signal transduction|regulation of sequence-specific DNA binding transcription factor activity|stress-activated MAPK cascade|synaptic transmission|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|transcription, DNA-dependent	cytosol|nucleoplasm	ATP binding|DNA binding|MAP kinase activity|phosphatase binding|RNA polymerase II carboxy-terminal domain kinase activity			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3	Colorectal(54;0.105)	all_lung(157;3.89e-05)		READ - Rectum adenocarcinoma(21;0.0689)	Arsenic trioxide(DB01169)	TCATTTGCTCGATGGTTGGTG	0.403		NaN											0	0	0	0.00308	0	8	110									
ZNF280A	129025	broad.mit.edu	37	22	22868615	22868615	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr22:22868615C>T	uc002zwe.2	-	2	1593	c.1340G>A	c.(1339-1341)AGA>AAA	p.R447K	LOC96610_uc011aim.1_Intron	NM_080740	NP_542778	P59817	Z280A_HUMAN	zinc finger protein 280A	447					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1	all_hematologic(9;0.0135)|Acute lymphoblastic leukemia(84;0.17)	all_hematologic(6;1.74e-30)|Acute lymphoblastic leukemia(6;7.75e-22)		READ - Rectum adenocarcinoma(21;0.145)		GACCCTCCTTCTGCTGTGCCT	0.413		NaN											0	0	0	0.013726	0	33	143									
CRYBA4	1413	broad.mit.edu	37	22	27019252	27019252	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr22:27019252G>C	uc003acz.3	+	3	129	c.94G>C	c.(94-96)GAG>CAG	p.E32Q		NM_001886	NP_001877	P53673	CRBA4_HUMAN	crystallin, beta A4	32	Beta/gamma crystallin 'Greek key' 1.				camera-type eye development|visual perception	soluble fraction	structural constituent of eye lens				0						GTTCACGGCCGAGTGCCCCAG	0.592		NaN											0	0	0	0.003163	0	15	90									
MYH9	4627	broad.mit.edu	37	22	36681274	36681274	+	Silent	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr22:36681274G>A	uc003apg.2	-	38	5607	c.5376C>T	c.(5374-5376)GTC>GTT	p.V1792V		NM_002473	NP_002464	P35579	MYH9_HUMAN	myosin, heavy polypeptide 9, non-muscle	1792	Potential.				actin cytoskeleton reorganization|actin filament-based movement|angiogenesis|axon guidance|blood vessel endothelial cell migration|cytokinesis|integrin-mediated signaling pathway|leukocyte migration|membrane protein ectodomain proteolysis|monocyte differentiation|platelet formation|protein transport|regulation of cell shape	actomyosin contractile ring|cleavage furrow|cytosol|myosin complex|nucleus|ruffle|stress fiber|uropod	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity|protein anchor|protein homodimerization activity			breast(3)|ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|lung(1)|skin(1)|kidney(1)|pancreas(1)	11						CCTGCAGCTTGACCTTAAGCT	0.587		NaN	T	ALK	ALCL		Deafness|autosomal dominant 17|Epstein syndrome|Fechtner syndrome|May-Hegglin anomaly|Sebastian syndrome		Hereditary_Macrothrombocytopenia_MYH9-associated				0	0	0	0.004656	0	26	88									
TCF20	6942	broad.mit.edu	37	22	42609885	42609885	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr22:42609885G>T	uc003bcj.1	-	1	1561	c.1427C>A	c.(1426-1428)TCT>TAT	p.S476Y	TCF20_uc003bck.1_Missense_Mutation_p.S476Y|TCF20_uc003bnt.2_Missense_Mutation_p.S476Y	NM_005650	NP_005641	Q9UGU0	TCF20_HUMAN	transcription factor 20 isoform 1	476					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|transcription coactivator activity|zinc ion binding			ovary(4)|skin(1)	5						CAGGGCATCAGAAAGTAACAT	0.478		NaN											1	0	1.55811e-20	0.008361	1.63806e-20	31	197									
TCF20	6942	broad.mit.edu	37	22	42610021	42610021	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr22:42610021G>C	uc003bcj.1	-	1	1425	c.1291C>G	c.(1291-1293)CAT>GAT	p.H431D	TCF20_uc003bck.1_Missense_Mutation_p.H431D|TCF20_uc003bnt.2_Missense_Mutation_p.H431D	NM_005650	NP_005641	Q9UGU0	TCF20_HUMAN	transcription factor 20 isoform 1	431					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|transcription coactivator activity|zinc ion binding			ovary(4)|skin(1)	5						CCTGCAGCATGAGAATTAGGA	0.488		NaN											0	0	0	0.005443	0	27	120									
MCAT	27349	broad.mit.edu	37	22	43538972	43538972	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr22:43538972G>A	uc003bdl.1	-	1	432	c.383C>T	c.(382-384)TCG>TTG	p.S128L	MCAT_uc003bdm.1_Missense_Mutation_p.S128L	NM_173467	NP_775738	Q8IVS2	FABD_HUMAN	mitochondrial malonyltransferase isoform a	128					fatty acid biosynthetic process	mitochondrion	[acyl-carrier-protein] S-malonyltransferase activity|binding			ovary(1)	1		Ovarian(80;0.0694)				AGCGGCCAGCGATGCCACGAA	0.682		NaN											0	0	0	0.009096	0	3	5									
SCUBE1	80274	broad.mit.edu	37	22	43634897	43634897	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr22:43634897C>T	uc003bdt.1	-	7	879	c.791G>A	c.(790-792)CGA>CAA	p.R264Q	SCUBE1_uc003bdu.1_Missense_Mutation_p.R294Q	NM_173050	NP_766638	Q8IWY4	SCUB1_HUMAN	signal peptide, CUB domain, EGF-like 1	264	EGF-like 5 (Potential).|EGF-like 6 (Potential).				adult heart development|blood coagulation|endothelial cell differentiation|inflammatory response|post-embryonic development|protein homooligomerization	external side of plasma membrane|extracellular space|extrinsic to plasma membrane	calcium ion binding|identical protein binding|protein heterodimerization activity			central_nervous_system(2)|ovary(1)|lung(1)|skin(1)	5		all_neural(38;0.0414)|Ovarian(80;0.07)				GCAGCTGCATCGCACGCCAGT	0.607		NaN											0	0	0	0.006214	0	8	21									
CELSR1	9620	broad.mit.edu	37	22	46932099	46932099	+	Silent	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr22:46932099C>T	uc003bhw.1	-	1	969	c.969G>A	c.(967-969)GTG>GTA	p.V323V		NM_014246	NP_055061	Q9NYQ6	CELR1_HUMAN	cadherin EGF LAG seven-pass G-type receptor 1	323	Extracellular (Potential).|Cadherin 1.				central nervous system development|homophilic cell adhesion|neural tube closure|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein dimerization activity			lung(4)|breast(4)|pancreas(2)|skin(1)	11		Ovarian(80;0.00142)|Breast(42;0.00296)|all_neural(38;0.0416)|Colorectal(5;0.0766)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00643)|BRCA - Breast invasive adenocarcinoma(115;0.171)		CCACGGCTTTCACCCTGAGGA	0.642		NaN											0	0	0	0.001984	0	7	62									
MIOX	55586	broad.mit.edu	37	22	50928201	50928201	+	Silent	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr22:50928201C>T	uc003bll.1	+	10	888	c.774C>T	c.(772-774)TGC>TGT	p.C258C	MIOX_uc003blm.1_Missense_Mutation_p.P254S|MIOX_uc003bln.1_Missense_Mutation_p.P215S	NM_017584	NP_060054	Q9UGB7	MIOX_HUMAN	myo-inositol oxygenase	258					inositol catabolic process	cytoplasm|inclusion body	aldo-keto reductase (NADP) activity|ferric iron binding|inositol oxygenase activity				0		all_cancers(38;4.58e-14)|all_epithelial(38;1.12e-12)|all_lung(38;3.07e-05)|Breast(42;6.27e-05)|Lung NSC(38;0.000813)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		ACACCAAGTGCCCGGACCTGC	0.642		NaN											0	0	0	0.012213	0	28	56									
OXTR	5021	broad.mit.edu	37	3	8809175	8809175	+	Silent	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr3:8809175G>A	uc003brc.2	-	3	1321	c.699C>T	c.(697-699)CTC>CTT	p.L233L		NM_000916	NP_000907	P30559	OXYR_HUMAN	oxytocin receptor	233	Cytoplasmic (Potential).				female pregnancy|lactation|muscle contraction	integral to plasma membrane	oxytocin receptor activity|vasopressin receptor activity				0				OV - Ovarian serous cystadenocarcinoma(96;0.15)	Carbetocin(DB01282)	CAGCGGTCTTGAGCCGCAAGT	0.657		NaN											0	0	0	0.009096	0	4	14									
OGG1	4968	broad.mit.edu	37	3	9792844	9792844	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr3:9792844C>T	uc003bsi.2	+	2	696	c.353C>T	c.(352-354)TCC>TTC	p.S118F	OGG1_uc003bsh.2_Missense_Mutation_p.S118F|OGG1_uc003bsj.2_Missense_Mutation_p.S118F|OGG1_uc003bsk.2_Missense_Mutation_p.S118F|OGG1_uc003bsl.2_Missense_Mutation_p.S118F|OGG1_uc003bsm.2_Missense_Mutation_p.S118F|OGG1_uc003bsn.2_Missense_Mutation_p.S118F|OGG1_uc003bso.2_Missense_Mutation_p.S118F|OGG1_uc003bsp.1_5'Flank|OGG1_uc010hcm.1_5'Flank|OGG1_uc003bsq.1_5'Flank|OGG1_uc003bsr.1_5'Flank	NM_002542	NP_002533	O15527	OGG1_HUMAN	8-oxoguanine DNA-glycosylase 1 isoform 1a	118					depurination|nucleotide-excision repair|regulation of protein import into nucleus, translocation|regulation of transcription, DNA-dependent|response to oxidative stress|response to radiation	mitochondrion|nuclear matrix|nuclear speck	damaged DNA binding|endonuclease activity|oxidized purine base lesion DNA N-glycosylase activity|protein binding				0	Medulloblastoma(99;0.227)					TCCGTGGACTCCCACTTCCAA	0.473		NaN						BER_DNA_glycosylases					0	0	0	0.012319	0	21	31									
IL17RC	84818	broad.mit.edu	37	3	9974537	9974537	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr3:9974537C>T	uc003bua.2	+	18	1966	c.1730C>T	c.(1729-1731)TCG>TTG	p.S577L	CIDEC_uc003bto.2_Intron|IL17RC_uc003btz.2_Missense_Mutation_p.S506L|IL17RC_uc011atp.1_Intron|IL17RC_uc003bud.2_Missense_Mutation_p.S47L|IL17RC_uc003bub.2_Missense_Mutation_p.S491L|IL17RC_uc010hct.2_Intron|IL17RC_uc010hcu.2_Intron|IL17RC_uc010hcv.2_Missense_Mutation_p.S474L|IL17RC_uc011atq.1_Missense_Mutation_p.S491L|IL17RC_uc003buc.2_Intron|IL17RC_uc003bue.2_Intron|CRELD1_uc003buf.2_5'Flank|CRELD1_uc003bug.2_5'Flank|CRELD1_uc003buh.2_5'Flank|CRELD1_uc003bui.2_5'Flank|CRELD1_uc003buj.2_5'Flank	NM_153461	NP_703191	Q8NAC3	I17RC_HUMAN	interleukin 17 receptor C isoform 1 precursor	577	Cytoplasmic (Potential).					integral to membrane|plasma membrane	receptor activity			ovary(1)|pancreas(1)	2						GACGTCCGCTCGGGGGGTGAG	0.692		NaN									OREG0015383	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.001984	0	4	7									
TMEM40	55287	broad.mit.edu	37	3	12783971	12783971	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr3:12783971C>T	uc003bxg.1	-	5	464	c.337G>A	c.(337-339)GAG>AAG	p.E113K	TMEM40_uc003bxh.1_Missense_Mutation_p.E83K|TMEM40_uc003bxi.1_Missense_Mutation_p.E37K|TMEM40_uc011auv.1_Missense_Mutation_p.E129K	NM_018306	NP_060776	Q8WWA1	TMM40_HUMAN	transmembrane protein 40	113						integral to membrane					0						AGTTGAAGCTCATCCTTCAAA	0.507		NaN											0	0	0	0.007291	0	26	196									
FBXL2	25827	broad.mit.edu	37	3	33400807	33400807	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr3:33400807C>G	uc003cfp.2	+	4	224	c.153C>G	c.(151-153)AAC>AAG	p.N51K	FBXL2_uc011axm.1_RNA|FBXL2_uc011axn.1_RNA|FBXL2_uc011axo.1_5'UTR|FBXL2_uc011axp.1_Intron|FBXL2_uc011axq.1_Intron|FBXL2_uc011axr.1_Intron|FBXL2_uc011axs.1_RNA	NM_012157	NP_036289	Q9UKC9	FBXL2_HUMAN	F-box and leucine-rich repeat protein 2	51	F-box.				interspecies interaction between organisms|proteolysis	cytoplasm|membrane	protein binding|ubiquitin-protein ligase activity			large_intestine(1)	1						ATGGAAGCAACTGGCAAAGAA	0.378		NaN											0	0	0	0.008291	0	9	73									
GORASP1	64689	broad.mit.edu	37	3	39139937	39139937	+	Silent	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr3:39139937C>T	uc003ciw.1	-	9	1211	c.1113G>A	c.(1111-1113)CTG>CTA	p.L371L	GORASP1_uc003civ.1_RNA|GORASP1_uc003cix.1_RNA|GORASP1_uc003ciy.1_RNA|GORASP1_uc011ayw.1_Silent_p.L276L|GORASP1_uc003ciz.1_Silent_p.L216L	NM_031899	NP_114105	Q9BQQ3	GORS1_HUMAN	Golgi reassembly stacking protein 1	371					mitotic prophase|protein transport	cytosol|Golgi apparatus|membrane				ovary(2)|central_nervous_system(1)	3				KIRC - Kidney renal clear cell carcinoma(284;0.0519)|Kidney(284;0.0653)		CTGGGCTGTCCAGGAAGGAGA	0.592		NaN											0	0	0	0.00245	0	15	33									
CCDC13	152206	broad.mit.edu	37	3	42777313	42777313	+	Silent	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr3:42777313C>T	uc003cly.3	-	10	1341	c.1257G>A	c.(1255-1257)CTG>CTA	p.L419L		NM_144719	NP_653320	Q8IYE1	CCD13_HUMAN	coiled-coil domain containing 13	419	Potential.									ovary(1)	1						CCTCGCTGTTCAGTTGCTGGT	0.622		NaN											0	0	0	0.010504	0	22	63									
CDCP1	64866	broad.mit.edu	37	3	45152268	45152268	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr3:45152268G>A	uc003com.2	-	4	856	c.721C>T	c.(721-723)CCA>TCA	p.P241S	CDCP1_uc003con.2_Missense_Mutation_p.P241S	NM_022842	NP_073753	Q9H5V8	CDCP1_HUMAN	CUB domain-containing protein 1 isoform 1	241	Extracellular (Potential).					extracellular region|integral to membrane|plasma membrane				ovary(1)|central_nervous_system(1)|skin(1)	3				BRCA - Breast invasive adenocarcinoma(193;0.00928)|KIRC - Kidney renal clear cell carcinoma(197;0.0519)|Kidney(197;0.0651)		AAGCCTTCTGGGTAGTTGGCA	0.542		NaN											0	0	0	0.01441	0	94	169									
CCR3	1232	broad.mit.edu	37	3	46307616	46307616	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr3:46307616C>T	uc003cpg.1	+	4	1510	c.967C>T	c.(967-969)CAC>TAC	p.H323Y	CCR3_uc003cpi.1_Missense_Mutation_p.H323Y|CCR3_uc003cpj.1_Missense_Mutation_p.H323Y|CCR3_uc003cpk.1_Missense_Mutation_p.H344Y|CCR3_uc010hjb.1_Missense_Mutation_p.H341Y|CCR3_uc003cpl.1_Missense_Mutation_p.H356Y	NM_178329	NP_847899	P51677	CCR3_HUMAN	CC chemokine receptor 3 isoform 1	323	Cytoplasmic (Potential).				cell adhesion|cellular defense response|chemotaxis|elevation of cytosolic calcium ion concentration|G-protein signaling, coupled to cAMP nucleotide second messenger|inflammatory response|interspecies interaction between organisms|positive regulation of angiogenesis	integral to plasma membrane				ovary(3)|lung(3)|breast(1)|kidney(1)	8				BRCA - Breast invasive adenocarcinoma(193;0.00119)|KIRC - Kidney renal clear cell carcinoma(197;0.0183)|Kidney(197;0.0216)		CTTGCTCATGCACCTGGGCAG	0.532		NaN											0	0	0	0.00632	0	29	56									
NBEAL2	23218	broad.mit.edu	37	3	47044731	47044731	+	Silent	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr3:47044731G>A	uc003cqp.2	+	35	5831	c.5652G>A	c.(5650-5652)GTG>GTA	p.V1884V	NBEAL2_uc010hjm.1_Silent_p.V1261V|NBEAL2_uc010hjn.1_Silent_p.V280V|NBEAL2_uc010hjo.1_5'Flank	NM_015175	NP_055990	Q6ZNJ1	NBEL2_HUMAN	neurobeachin-like 2	1884							binding			ovary(1)	1		Acute lymphoblastic leukemia(5;0.0534)		BRCA - Breast invasive adenocarcinoma(193;0.0012)|KIRC - Kidney renal clear cell carcinoma(197;0.00575)|Kidney(197;0.00656)		AGGCCAAAGTGAGCACCCCAC	0.637		NaN											0	0	0	0.000602	0	4	32									
SETD2	29072	broad.mit.edu	37	3	47164187	47164187	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr3:47164187C>T	uc003cqs.2	-	3	1992	c.1939G>A	c.(1939-1941)GAT>AAT	p.D647N	SETD2_uc003cqv.2_Missense_Mutation_p.D636N	NM_014159	NP_054878	Q9BYW2	SETD2_HUMAN	SET domain containing 2	647					regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	DNA binding|histone-lysine N-methyltransferase activity|oxidoreductase activity|transition metal ion binding			kidney(24)|ovary(5)|skin(1)|central_nervous_system(1)|breast(1)	32		Acute lymphoblastic leukemia(5;0.0169)		BRCA - Breast invasive adenocarcinoma(193;0.000302)|KIRC - Kidney renal clear cell carcinoma(197;0.00732)|Kidney(197;0.00844)		TTAATACTATCATGGCTATCA	0.318		NaN	N|F|S|Mis		clear cell renal carcinoma								0	0	0	0.004007	0	17	110									
STAB1	23166	broad.mit.edu	37	3	52538540	52538540	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr3:52538540C>A	uc003dej.2	+	11	1288	c.1214C>A	c.(1213-1215)TCC>TAC	p.S405Y	STAB1_uc003dei.1_Missense_Mutation_p.S405Y	NM_015136	NP_055951	Q9NY15	STAB1_HUMAN	stabilin 1 precursor	405	Extracellular (Potential).|FAS1 1.				cell adhesion|cell-cell signaling|defense response to bacterium|inflammatory response|negative regulation of angiogenesis|receptor-mediated endocytosis	integral to plasma membrane	bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			large_intestine(3)|upper_aerodigestive_tract(2)|central_nervous_system(1)|breast(1)|skin(1)|pancreas(1)	9				BRCA - Breast invasive adenocarcinoma(193;1.73e-05)|Kidney(197;0.00182)|KIRC - Kidney renal clear cell carcinoma(197;0.00205)|OV - Ovarian serous cystadenocarcinoma(275;0.0482)		CCATCCGTCTCCTCCTTCTCC	0.642		NaN											1	0	7.93312e-07	0.00245	8.1363e-07	13	60									
RFT1	91869	broad.mit.edu	37	3	53159984	53159984	+	Silent	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr3:53159984G>A	uc003dgj.2	-	2	144	c.90C>T	c.(88-90)GTC>GTT	p.V30V	RFT1_uc003dgk.2_Silent_p.V30V	NM_052859	NP_443091	Q96AA3	RFT1_HUMAN	RFT1 homolog	30	Helical; (Potential).				carbohydrate transport|dolichol-linked oligosaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	integral to membrane	lipid transporter activity			skin(1)	1				BRCA - Breast invasive adenocarcinoma(193;6.98e-05)|Kidney(197;0.0017)|KIRC - Kidney renal clear cell carcinoma(197;0.00192)|OV - Ovarian serous cystadenocarcinoma(275;0.104)		ATGCATTCAAGACAAAGGTGA	0.393		NaN											0	0	0	0.009096	0	3	41									
FLNB	2317	broad.mit.edu	37	3	58109122	58109122	+	Silent	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr3:58109122C>T	uc003djj.2	+	21	3594	c.3429C>T	c.(3427-3429)CTC>CTT	p.L1143L	FLNB_uc010hne.2_Silent_p.L1143L|FLNB_uc003djk.2_Silent_p.L1143L|FLNB_uc010hnf.2_Silent_p.L1143L|FLNB_uc003djl.2_Silent_p.L974L|FLNB_uc003djm.2_Silent_p.L974L	NM_001457	NP_001448	O75369	FLNB_HUMAN	filamin B isoform 2	1143	Interaction with FBLP1.|Filamin 10.				actin cytoskeleton organization|cell differentiation|cytoskeletal anchoring at plasma membrane|signal transduction	cell cortex|integral to membrane|nucleus|sarcomere	actin binding			breast(8)|ovary(5)|lung(3)|skin(2)|central_nervous_system(1)	19				BRCA - Breast invasive adenocarcinoma(55;0.000335)|KIRC - Kidney renal clear cell carcinoma(284;0.0726)|Kidney(284;0.0898)		GGCCAGGTCTCGAGCACGGGA	0.592		NaN											0	0	0	0.01441	0	57	119									
CADPS	8618	broad.mit.edu	37	3	62423858	62423858	+	Missense_Mutation	SNP	T	T	C			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr3:62423858T>C	uc003dll.2	-	28	4058	c.3698A>G	c.(3697-3699)TAC>TGC	p.Y1233C	CADPS_uc003dlj.1_Missense_Mutation_p.Y188C|CADPS_uc003dlk.1_Missense_Mutation_p.Y681C|CADPS_uc003dlm.2_Missense_Mutation_p.Y1194C|CADPS_uc003dln.2_Missense_Mutation_p.Y1154C	NM_003716	NP_003707	Q9ULU8	CAPS1_HUMAN	Ca2+-dependent secretion activator isoform 1	1233	Mediates targeting and association with DCVs (By similarity).				exocytosis|protein transport	cell junction|cytoplasmic vesicle membrane|cytosol|synapse	lipid binding|metal ion binding			central_nervous_system(2)|ovary(1)	3		Lung SC(41;0.0452)		BRCA - Breast invasive adenocarcinoma(55;5.98e-05)|KIRC - Kidney renal clear cell carcinoma(15;0.0246)|Kidney(15;0.0334)		GAAAGTCACGTAGGCGTCGGC	0.443		NaN											0	0	0	0.003163	0	15	36									
GXYLT2	727936	broad.mit.edu	37	3	73004392	73004393	+	Missense_Mutation	DNP	GA	GA	CT			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr3:73004392_73004393GA>CT	uc003dpg.2	+	4	744_745	c.744_745GA>CT	c.(742-747)AAGATT>AACTTT	p.248_249KI>NF		NM_001080393	NP_001073862	A0PJZ3	GXLT2_HUMAN	glycosyltransferase 8 domain containing 4	248_249	Lumenal (Potential).				O-glycan processing	integral to membrane	UDP-xylosyltransferase activity				0						AAATCCCCAAGATTGGCTGGTA	0.475		NaN											0	0	0	0.004672	0	8	30									
C3orf38	285237	broad.mit.edu	37	3	88205273	88205273	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr3:88205273C>G	uc003dqw.2	+	4	789	c.478C>G	c.(478-480)CTA>GTA	p.L160V		NM_173824	NP_776185	Q5JPI3	CC038_HUMAN	hypothetical protein LOC285237	160					apoptosis						0		Lung NSC(201;0.17)		UCEC - Uterine corpus endometrioid carcinoma (27;0.194)|LUSC - Lung squamous cell carcinoma(29;0.00353)|Lung(72;0.00661)		GAATCCTTTTCTAGGACCACC	0.388		NaN											0	0	0	0.01441	0	48	114									
OR5K3	403277	broad.mit.edu	37	3	98110249	98110249	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr3:98110249C>T	uc011bgw.1	+	1	740	c.740C>T	c.(739-741)TCA>TTA	p.S247L		NM_001005516	NP_001005516	A6NET4	OR5K3_HUMAN	olfactory receptor, family 5, subfamily K,	247	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						CTCTCTGTGTCAATATTCTGT	0.353		NaN											0	0	0	0.01441	0	70	134									
GPR15	2838	broad.mit.edu	37	3	98251707	98251707	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr3:98251707C>T	uc011bgy.1	+	1	830	c.830C>T	c.(829-831)TCA>TTA	p.S277L		NM_005290	NP_005281	P49685	GPR15_HUMAN	G protein-coupled receptor 15	277	Extracellular (Potential).					integral to plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			ovary(1)	1		Lung NSC(201;7.93e-06)|all_neural(597;0.00172)|Hepatocellular(537;0.00825)|Myeloproliferative disorder(1037;0.0255)		Lung(72;0.246)		TATTTACCCTCAGCTATTCTT	0.478		NaN											0	0	0	0.012319	0	22	143									
GPR128	84873	broad.mit.edu	37	3	100354655	100354655	+	Silent	SNP	A	A	G			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr3:100354655A>G	uc003duc.2	+	5	850	c.582A>G	c.(580-582)AGA>AGG	p.R194R	GPR128_uc011bhc.1_5'UTR	NM_032787	NP_116176	Q96K78	GP128_HUMAN	G protein-coupled receptor 128 precursor	194	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(3)|skin(1)	4						ACACTTCCAGAAATGCTTCAC	0.373		NaN											0	0	0	0.013114	0	34	56									
RG9MTD1	54931	broad.mit.edu	37	3	101284754	101284754	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr3:101284754C>G	uc003duz.2	+	2	1277	c.1129C>G	c.(1129-1131)CCC>GCC	p.P377A		NM_017819	NP_060289	Q7L0Y3	MRRP1_HUMAN	RNA (guanine-9-) methyltransferase domain	377					tRNA processing	mitochondrion	methyltransferase activity|protein binding			ovary(1)	1						GCAATTCGTTCCCAAGAGAAA	0.343		NaN											0	0	0	0.01441	0	51	82									
CD47	961	broad.mit.edu	37	3	107778373	107778373	+	Missense_Mutation	SNP	T	T	C			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr3:107778373T>C	uc003dwt.1	-	5	797	c.617A>G	c.(616-618)AAT>AGT	p.N206S	CD47_uc003dwu.1_Missense_Mutation_p.N206S|CD47_uc003dwv.1_Missense_Mutation_p.N206S|CD47_uc003dww.1_Missense_Mutation_p.N206S	NM_001777	NP_001768	Q08722	CD47_HUMAN	CD47 antigen isoform 1 precursor	206	Extracellular (Potential).				blood coagulation|cell adhesion|cell junction assembly|integrin-mediated signaling pathway|leukocyte migration|positive regulation of cell proliferation|positive regulation of cell-cell adhesion|positive regulation of T cell activation	integral to plasma membrane	protein binding|thrombospondin receptor activity			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(3;0.0191)|Epithelial(53;0.118)			GCCAGTAGCATTCTTTAATGA	0.284		NaN											0	0	0	0.014323	0	21	165									
SIDT1	54847	broad.mit.edu	37	3	113321989	113321989	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr3:113321989C>T	uc003eak.2	+	12	1906	c.1255C>T	c.(1255-1257)CGG>TGG	p.R419W	SIDT1_uc011bif.1_RNA|SIDT1_uc003eaj.1_Missense_Mutation_p.R419W|SIDT1_uc011big.1_Missense_Mutation_p.R172W|SIDT1_uc011bih.1_RNA|SIDT1_uc011bii.1_5'Flank	NM_017699	NP_060169	Q9NXL6	SIDT1_HUMAN	SID1 transmembrane family, member 1 precursor	419	Cytoplasmic (Potential).					integral to membrane				ovary(3)|pancreas(1)|skin(1)	5						AAACATCATCCGGACCAAGGT	0.507		NaN											0	0	0	0.008291	0	9	62									
KIAA2018	205717	broad.mit.edu	37	3	113393710	113393710	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr3:113393710C>T	uc003eam.2	-	3	427	c.16G>A	c.(16-18)GAG>AAG	p.E6K		NM_001009899	NP_001009899	Q68DE3	K2018_HUMAN	hypothetical protein LOC205717	6					regulation of transcription, DNA-dependent	membrane|nucleus	calcium ion binding|DNA binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity			skin(2)|ovary(1)	3						GTCTCATTCTCTGTCATTTCT	0.383		NaN											0	0	0	0.00632	0	26	192									
POLQ	10721	broad.mit.edu	37	3	121207358	121207358	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr3:121207358C>T	uc003eee.3	-	16	4549	c.4420G>A	c.(4420-4422)GAA>AAA	p.E1474K	POLQ_uc003eed.2_Missense_Mutation_p.E646K	NM_199420	NP_955452	O75417	DPOLQ_HUMAN	DNA polymerase theta	1474					DNA repair|DNA replication	nucleoplasm	ATP binding|ATP-dependent helicase activity|damaged DNA binding|DNA-directed DNA polymerase activity|single-stranded DNA-dependent ATPase activity			ovary(4)|breast(3)|lung(2)|upper_aerodigestive_tract(1)|skin(1)	11				GBM - Glioblastoma multiforme(114;0.0915)		GGAAGACATTCTCCTTCTACA	0.333		NaN						DNA_polymerases_(catalytic_subunits)					0	0	0	0.009535	0	33	171									
GOLGB1	2804	broad.mit.edu	37	3	121414092	121414092	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr3:121414092C>G	uc003eei.3	-	13	5389	c.5263G>C	c.(5263-5265)GAG>CAG	p.E1755Q	GOLGB1_uc010hrc.2_Missense_Mutation_p.E1760Q|GOLGB1_uc003eej.3_Missense_Mutation_p.E1721Q|GOLGB1_uc011bjm.1_Missense_Mutation_p.E1641Q|GOLGB1_uc010hrd.1_Missense_Mutation_p.E1719Q	NM_004487	NP_004478	Q14789	GOGB1_HUMAN	golgi autoantigen, golgin subfamily b,	1755	Cytoplasmic (Potential).|Potential.				Golgi organization	ER-Golgi intermediate compartment|Golgi membrane|Golgi stack|integral to membrane	protein binding			ovary(6)|breast(2)|skin(2)	10				GBM - Glioblastoma multiforme(114;0.0989)		TCTTGAACCTCTTCACTTAGA	0.383		NaN											0	0	0	0.01441	0	88	329									
GOLGB1	2804	broad.mit.edu	37	3	121414425	121414425	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr3:121414425G>A	uc003eei.3	-	13	5056	c.4930C>T	c.(4930-4932)CAA>TAA	p.Q1644*	GOLGB1_uc010hrc.2_Nonsense_Mutation_p.Q1649*|GOLGB1_uc003eej.3_Nonsense_Mutation_p.Q1610*|GOLGB1_uc011bjm.1_Nonsense_Mutation_p.Q1530*|GOLGB1_uc010hrd.1_Nonsense_Mutation_p.Q1608*	NM_004487	NP_004478	Q14789	GOGB1_HUMAN	golgi autoantigen, golgin subfamily b,	1644	Cytoplasmic (Potential).|Potential.				Golgi organization	ER-Golgi intermediate compartment|Golgi membrane|Golgi stack|integral to membrane	protein binding			ovary(6)|breast(2)|skin(2)	10				GBM - Glioblastoma multiforme(114;0.0989)		TACAGTTCTTGTTTCTCTTGC	0.408		NaN											0	0	0	0.01441	0	137	227									
GOLGB1	2804	broad.mit.edu	37	3	121416388	121416388	+	Silent	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr3:121416388C>T	uc003eei.3	-	13	3093	c.2967G>A	c.(2965-2967)GAG>GAA	p.E989E	GOLGB1_uc010hrc.2_Silent_p.E994E|GOLGB1_uc003eej.3_Silent_p.E955E|GOLGB1_uc011bjm.1_Silent_p.E875E|GOLGB1_uc010hrd.1_Silent_p.E953E	NM_004487	NP_004478	Q14789	GOGB1_HUMAN	golgi autoantigen, golgin subfamily b,	989	Cytoplasmic (Potential).|Potential.				Golgi organization	ER-Golgi intermediate compartment|Golgi membrane|Golgi stack|integral to membrane	protein binding			ovary(6)|breast(2)|skin(2)	10				GBM - Glioblastoma multiforme(114;0.0989)		TCTTTCTCTGCTCATTTTCTT	0.388		NaN											0	0	0	0.01441	0	61	190									
GOLGB1	2804	broad.mit.edu	37	3	121416969	121416969	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr3:121416969C>T	uc003eei.3	-	13	2512	c.2386G>A	c.(2386-2388)GAA>AAA	p.E796K	GOLGB1_uc010hrc.2_Missense_Mutation_p.E801K|GOLGB1_uc003eej.3_Missense_Mutation_p.E762K|GOLGB1_uc011bjm.1_Missense_Mutation_p.E682K|GOLGB1_uc010hrd.1_Missense_Mutation_p.E760K	NM_004487	NP_004478	Q14789	GOGB1_HUMAN	golgi autoantigen, golgin subfamily b,	796	Cytoplasmic (Potential).|Potential.				Golgi organization	ER-Golgi intermediate compartment|Golgi membrane|Golgi stack|integral to membrane	protein binding			ovary(6)|breast(2)|skin(2)	10				GBM - Glioblastoma multiforme(114;0.0989)		TGGATCTGTTCAGTGAGCAGG	0.418		NaN											0	0	0	0.01441	0	94	226									
GOLGB1	2804	broad.mit.edu	37	3	121417118	121417118	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr3:121417118C>G	uc003eei.3	-	13	2363	c.2237G>C	c.(2236-2238)AGA>ACA	p.R746T	GOLGB1_uc010hrc.2_Missense_Mutation_p.R751T|GOLGB1_uc003eej.3_Missense_Mutation_p.R712T|GOLGB1_uc011bjm.1_Missense_Mutation_p.R632T|GOLGB1_uc010hrd.1_Missense_Mutation_p.R710T	NM_004487	NP_004478	Q14789	GOGB1_HUMAN	golgi autoantigen, golgin subfamily b,	746	Cytoplasmic (Potential).|Potential.				Golgi organization	ER-Golgi intermediate compartment|Golgi membrane|Golgi stack|integral to membrane	protein binding			ovary(6)|breast(2)|skin(2)	10				GBM - Glioblastoma multiforme(114;0.0989)		AAGCTGGTCTCTTTCTTCAGA	0.423		NaN											0	0	0	0.01441	0	63	175									
KPNA1	3836	broad.mit.edu	37	3	122168479	122168479	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr3:122168479C>G	uc003efd.1	-	9	895	c.859G>C	c.(859-861)GAT>CAT	p.D287H	KPNA1_uc003efb.1_Missense_Mutation_p.D86H|KPNA1_uc003efc.1_Missense_Mutation_p.D86H|KPNA1_uc011bjr.1_Missense_Mutation_p.D86H|KPNA1_uc010hrh.2_Missense_Mutation_p.D86H|KPNA1_uc003efe.2_Missense_Mutation_p.D287H	NM_002264	NP_002255	P52294	IMA1_HUMAN	karyopherin alpha 1	287	Binding to RAG1.|ARM 5.				DNA fragmentation involved in apoptotic nuclear change|NLS-bearing substrate import into nucleus|regulation of DNA recombination|viral genome transport in host cell|viral infectious cycle	cytosol|nuclear pore|nucleoplasm	nuclear localization sequence binding|protein binding|protein transporter activity				0				GBM - Glioblastoma multiforme(114;0.0898)		TGAATTTTATCATTGGGTCCA	0.458		NaN											0	0	0	0.006122	0	18	102									
KALRN	8997	broad.mit.edu	37	3	124165699	124165699	+	Silent	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr3:124165699G>A	uc003ehg.2	+	21	3640	c.3513G>A	c.(3511-3513)CTG>CTA	p.L1171L	KALRN_uc010hrv.1_Silent_p.L1162L|KALRN_uc003ehf.1_Silent_p.L1171L|KALRN_uc011bjy.1_Silent_p.L1162L|KALRN_uc003ehh.1_Silent_p.L517L	NM_001024660	NP_001019831	O60229	KALRN_HUMAN	kalirin, RhoGEF kinase isoform 1	1171	Spectrin 5.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|vesicle-mediated transport	actin cytoskeleton|cytosol	ATP binding|GTPase activator activity|metal ion binding|protein binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			large_intestine(2)|ovary(2)|central_nervous_system(1)|skin(1)	6						AGGAACTGCTGAAAGAATATG	0.502		NaN											0	0	0	0.01441	0	71	137									
MCM2	4171	broad.mit.edu	37	3	127327705	127327705	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr3:127327705G>A	uc003ejp.2	+	8	1324	c.1267G>A	c.(1267-1269)GAT>AAT	p.D423N	MCM2_uc011bkm.1_Missense_Mutation_p.D293N|MCM2_uc010hsl.2_RNA|MCM2_uc011bkn.1_Missense_Mutation_p.D307N	NM_004526	NP_004517	P49736	MCM2_HUMAN	minichromosome maintenance complex component 2	423					cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	chromatin|MCM complex	ATP binding|helicase activity|metal ion binding			ovary(3)|skin(1)	4						CAACAACTATGATGGCTCCCT	0.567		NaN											0	0	0	0.01441	0	114	145									
PLXND1	23129	broad.mit.edu	37	3	129288723	129288723	+	Silent	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr3:129288723G>A	uc003emx.2	-	20	3928	c.3828C>T	c.(3826-3828)ATC>ATT	p.I1276I	PLXND1_uc011blb.1_5'Flank	NM_015103	NP_055918	Q9Y4D7	PLXD1_HUMAN	plexin D1 precursor	1276	Helical; (Potential).				axon guidance	integral to membrane|intracellular|plasma membrane				large_intestine(1)	1						TGCAGATGACGATGGACACGA	0.637		NaN											0	0	0	0.00308	0	7	48									
DNAJC13	23317	broad.mit.edu	37	3	132185190	132185190	+	Silent	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr3:132185190G>A	uc003eor.2	+	19	2081	c.2016G>A	c.(2014-2016)GAG>GAA	p.E672E	DNAJC13_uc010htq.1_Silent_p.E672E	NM_015268	NP_056083	O75165	DJC13_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 13	672							heat shock protein binding			ovary(1)|breast(1)	2						TCGTACCTGAGAAGGATGCTG	0.393		NaN											0	0	0	0.00245	0	14	121									
EPHB1	2047	broad.mit.edu	37	3	134967280	134967280	+	Silent	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr3:134967280G>A	uc003eqt.2	+	14	2839	c.2619G>A	c.(2617-2619)GAG>GAA	p.E873E	EPHB1_uc003equ.2_Silent_p.E434E	NM_004441	NP_004432	P54762	EPHB1_HUMAN	ephrin receptor EphB1 precursor	873	Cytoplasmic (Potential).|Protein kinase.					integral to plasma membrane	ATP binding|ephrin receptor activity|protein binding			lung(11)|ovary(6)|stomach(4)|breast(3)|central_nervous_system(2)|skin(2)|large_intestine(1)|pancreas(1)	30						GGTTTGCGGAGATTGTCAACA	0.572		NaN											0	0	0	0.00499	0	17	35									
MSL2	55167	broad.mit.edu	37	3	135913931	135913931	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr3:135913931G>A	uc003eqx.1	-	1	758	c.25C>T	c.(25-27)CTC>TTC	p.L9F	MSL2_uc011bmb.1_5'Flank	NM_018133	NP_060603	Q9HCI7	MSL2_HUMAN	ring finger protein 184 isoform 1	9					histone H4-K16 acetylation	MSL complex	zinc ion binding			central_nervous_system(1)	1						GAAATGTAGAGAGCAGTAGCA	0.527		NaN											0	0	0	0.01441	0	99	199									
ESYT3	83850	broad.mit.edu	37	3	138187010	138187010	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr3:138187010C>T	uc003esk.2	+	12	1508	c.1282C>T	c.(1282-1284)CTT>TTT	p.L428F	ESYT3_uc010hug.2_RNA	NM_031913	NP_114119	A0FGR9	ESYT3_HUMAN	family with sequence similarity 62 (C2 domain	428						integral to membrane|plasma membrane					0						GCTTTCATTGCTTACTGACCA	0.587		NaN											0	0	0	0.010504	0	18	39									
ATR	545	broad.mit.edu	37	3	142184050	142184050	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr3:142184050C>G	uc003eux.3	-	41	7052	c.6930G>C	c.(6928-6930)AAG>AAC	p.K2310N	ATR_uc003euy.1_Missense_Mutation_p.K196N	NM_001184	NP_001175	Q13535	ATR_HUMAN	ataxia telangiectasia and Rad3 related protein	2310					cell cycle|cellular response to gamma radiation|cellular response to UV|DNA damage checkpoint|DNA repair|DNA replication|multicellular organismal development|negative regulation of DNA replication|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|protein autophosphorylation|replicative senescence	PML body	ATP binding|DNA binding|MutLalpha complex binding|MutSalpha complex binding|protein serine/threonine kinase activity			lung(5)|skin(5)|breast(4)|ovary(3)|stomach(1)|central_nervous_system(1)|liver(1)	20						AAGAAATCTTCTTTGGTTTCT	0.318		NaN						Other_conserved_DNA_damage_response_genes					0	0	0	0.007413	0	18	109									
C3orf58	205428	broad.mit.edu	37	3	143691397	143691397	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr3:143691397G>A	uc003evo.2	+	1	758	c.223G>A	c.(223-225)GAG>AAG	p.E75K	C3orf58_uc011bnl.1_5'Flank	NM_173552	NP_775823	Q8NDZ4	CC058_HUMAN	hypothetical protein LOC205428 isoform a	75						COPI vesicle coat|extracellular region				ovary(1)	1						GGTGGTATTCGAGGCGTGGGG	0.672		NaN											0	0	0	0.00632	0	24	51									
PLOD2	5352	broad.mit.edu	37	3	145804623	145804623	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr3:145804623C>A	uc003evs.1	-	10	1584	c.1078G>T	c.(1078-1080)GTA>TTA	p.V360L	PLOD2_uc003evq.1_5'Flank|PLOD2_uc011bnm.1_Missense_Mutation_p.V305L|PLOD2_uc003evr.1_Missense_Mutation_p.V360L	NM_000935	NP_000926	O00469	PLOD2_HUMAN	procollagen-lysine, 2-oxoglutarate 5-dioxygenase	360					protein modification process|response to hypoxia	rough endoplasmic reticulum membrane	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-lysine 5-dioxygenase activity|protein binding			ovary(1)|skin(1)	2					Vitamin C(DB00126)	TCTGGTCCTACTATTTTTATA	0.254		NaN											1	0	0.00198382	0.001984	0.0020089	7	23									
P2RY13	53829	broad.mit.edu	37	3	151046193	151046193	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr3:151046193G>C	uc003eyv.2	-	2	672	c.651C>G	c.(649-651)TTC>TTG	p.F217L	MED12L_uc011bnz.1_Intron|MED12L_uc003eyp.2_Intron	NM_176894	NP_795713	Q9BPV8	P2Y13_HUMAN	purinergic receptor P2Y, G-protein coupled, 13	217	Helical; Name=5; (Potential).					integral to membrane|plasma membrane				ovary(3)|lung(1)	4			LUSC - Lung squamous cell carcinoma(72;0.0189)|Lung(72;0.0278)			AAACAGTCCAGAAAATAAACT	0.358		NaN											0	0	0	0.00245	0	14	141									
SLC33A1	9197	broad.mit.edu	37	3	155571325	155571325	+	Silent	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr3:155571325G>A	uc003fan.3	-	1	843	c.462C>T	c.(460-462)TTC>TTT	p.F154F	SLC33A1_uc003fao.1_Silent_p.F154F	NM_004733	NP_004724	O00400	ACATN_HUMAN	acetyl-coenzyme A transporter	154	Helical; (Potential).				cell death|transmembrane transport	endoplasmic reticulum membrane|Golgi membrane|integral to plasma membrane|membrane fraction	acetyl-CoA transporter activity			ovary(2)|large_intestine(1)|pancreas(1)	4			Lung(72;0.11)|LUSC - Lung squamous cell carcinoma(72;0.114)			AATAGATCATGAAGAGTCCTA	0.468		NaN											0	0	0	0.003271	0	33	83									
IFT80	57560	broad.mit.edu	37	3	159995413	159995413	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr3:159995413G>A	uc011boy.1	-	17	2315	c.1882C>T	c.(1882-1884)CGA>TGA	p.R628*	IFT80_uc003fda.2_RNA|IFT80_uc003fdb.1_Nonsense_Mutation_p.R491*|IFT80_uc003fdd.1_Nonsense_Mutation_p.R311*|IFT80_uc003fde.1_Nonsense_Mutation_p.R491*	NM_020800	NP_065851	Q9P2H3	IFT80_HUMAN	WD repeat domain 56	628						cilium axoneme|microtubule basal body				ovary(1)	1			Lung(72;0.00334)|LUSC - Lung squamous cell carcinoma(72;0.00523)			GTCATATCTCGATTAGCAACT	0.343		NaN											0	0	0	0.007413	0	17	53									
NMD3	51068	broad.mit.edu	37	3	160958933	160958933	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr3:160958933G>C	uc003feb.1	+	10	972	c.853G>C	c.(853-855)GAT>CAT	p.D285H	NMD3_uc003fec.2_Missense_Mutation_p.D285H|NMD3_uc003fed.1_Missense_Mutation_p.D285H|NMD3_uc010hwh.2_Missense_Mutation_p.D105H	NM_015938	NP_057022	Q96D46	NMD3_HUMAN	NMD3 homolog	285					protein transport	cytoplasm|nucleolus|nucleoplasm				ovary(1)	1			Lung(72;0.00111)|LUSC - Lung squamous cell carcinoma(72;0.00156)			TCACCTCATTGATCCAAACAC	0.363		NaN											0	0	0	0.006122	0	17	154									
FNDC3B	64778	broad.mit.edu	37	3	172028660	172028660	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr3:172028660G>C	uc003fhy.2	+	11	1415	c.1243G>C	c.(1243-1245)GAG>CAG	p.E415Q	FNDC3B_uc003fhz.3_Missense_Mutation_p.E415Q|FNDC3B_uc003fia.2_Missense_Mutation_p.E346Q	NM_022763	NP_073600	Q53EP0	FND3B_HUMAN	fibronectin type III domain containing 3B	415	Fibronectin type-III 2.					endoplasmic reticulum|integral to membrane				ovary(2)|breast(1)	3	all_cancers(22;1.01e-18)|Ovarian(172;0.00167)|Breast(254;0.165)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)	GBM - Glioblastoma multiforme(1;0.0494)		CTACCTTTTAGAGTGGGATGA	0.313		NaN											0	0	0	0.006214	0	10	303									
ABCC5	10057	broad.mit.edu	37	3	183700753	183700753	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr3:183700753C>G	uc003fmg.2	-	6	799	c.634G>C	c.(634-636)GAG>CAG	p.E212Q	ABCC5_uc011bqt.1_5'UTR|ABCC5_uc010hxl.2_Missense_Mutation_p.E212Q	NM_005688	NP_005679	O15440	MRP5_HUMAN	ATP-binding cassette, sub-family C, member 5	212	ABC transmembrane type-1 1.					integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of substances|organic anion transmembrane transporter activity			ovary(2)|large_intestine(1)|central_nervous_system(1)	4	all_cancers(143;1.85e-10)|Ovarian(172;0.0303)		Epithelial(37;1.74e-35)|OV - Ovarian serous cystadenocarcinoma(80;6.48e-22)			AGGTTAGACTCTGTTGCCTGG	0.527		NaN											0	0	0	0.00278	0	22	126									
ECE2	9718	broad.mit.edu	37	3	184002817	184002817	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr3:184002817G>A	uc003fni.3	+	9	1464	c.1426G>A	c.(1426-1428)GAC>AAC	p.D476N	ECE2_uc011brh.1_Missense_Mutation_p.D329N|ECE2_uc003fnl.3_Missense_Mutation_p.D404N|ECE2_uc003fnm.3_Missense_Mutation_p.D358N|ECE2_uc003fnk.3_Missense_Mutation_p.D329N|ECE2_uc011bri.1_Missense_Mutation_p.D391N|ECE2_uc010hxv.2_Missense_Mutation_p.D120N	NM_014693	NP_055508	O60344	ECE2_HUMAN	endothelin converting enzyme 2 isoform A	476	Lumenal (Potential).|Endothelin-converting enzyme 2 region.				brain development|cardioblast differentiation|cell-cell signaling|peptide hormone processing	cytoplasmic vesicle membrane|Golgi membrane|integral to membrane	metal ion binding|metalloendopeptidase activity|methyltransferase activity			ovary(2)|skin(2)	4	all_cancers(143;1.39e-10)|Ovarian(172;0.0339)		Epithelial(37;8.28e-34)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			GGAGTTGAGTGACTCTGAGCC	0.552		NaN									OREG0015945	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.01441	0	49	126									
TNK2	10188	broad.mit.edu	37	3	195615316	195615316	+	Silent	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr3:195615316C>T	uc003fvu.1	-	2	687	c.144G>A	c.(142-144)AAG>AAA	p.K48K	TNK2_uc003fvs.1_Silent_p.K80K|TNK2_uc003fvt.1_Silent_p.K111K|TNK2_uc010hzw.1_RNA|TNK2_uc003fvv.1_5'Flank|TNK2_uc010hzx.1_Silent_p.K62K	NM_005781	NP_005772	Q07912	ACK1_HUMAN	tyrosine kinase, non-receptor, 2 isoform 1	48	SAM-like domain.				positive regulation of peptidyl-tyrosine phosphorylation|protein ubiquitination|small GTPase mediated signal transduction	adherens junction|cytoplasmic vesicle membrane|endosome|nucleus	ATP binding|GTPase inhibitor activity|metal ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding			ovary(3)|central_nervous_system(3)|lung(2)|stomach(1)|skin(1)	10	all_cancers(143;6.48e-09)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;1.46e-22)|OV - Ovarian serous cystadenocarcinoma(49;8.3e-19)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;0.000757)	Adenosine triphosphate(DB00171)	CCATGCCGATCTTCTCCAGGT	0.607		NaN											0	0	0	0.009096	0	4	65									
GAK	2580	broad.mit.edu	37	4	861130	861130	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr4:861130G>A	uc003gbm.3	-	21	2685	c.2486C>T	c.(2485-2487)TCA>TTA	p.S829L	GAK_uc003gbn.3_Missense_Mutation_p.S750L|GAK_uc010ibk.1_Missense_Mutation_p.S723L|GAK_uc010ibi.2_Missense_Mutation_p.S10L|GAK_uc010ibj.2_RNA|GAK_uc003gbl.3_Missense_Mutation_p.S693L	NM_005255	NP_005246	O14976	GAK_HUMAN	cyclin G associated kinase	829					cell cycle	focal adhesion|Golgi apparatus|perinuclear region of cytoplasm	ATP binding|heat shock protein binding|protein serine/threonine kinase activity			lung(2)|central_nervous_system(1)|skin(1)	4				Colorectal(103;0.219)		CCCTTCATCTGACACCTCACT	0.617		NaN											0	0	0	0.005443	0	23	114									
WHSC1	7468	broad.mit.edu	37	4	1918678	1918678	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr4:1918678C>A	uc003gdz.3	+	4	1017	c.841C>A	c.(841-843)CTC>ATC	p.L281I	WHSC1_uc003geb.3_Missense_Mutation_p.L281I|WHSC1_uc003gec.3_Missense_Mutation_p.L281I|WHSC1_uc003ged.3_Missense_Mutation_p.L281I|WHSC1_uc003gee.3_RNA|WHSC1_uc003gef.3_RNA|WHSC1_uc003gdx.2_Missense_Mutation_p.L281I|WHSC1_uc003gdy.1_Missense_Mutation_p.L281I|WHSC1_uc010icd.1_Missense_Mutation_p.L281I|WHSC1_uc003gea.1_Missense_Mutation_p.L281I|WHSC1_uc010ice.1_Missense_Mutation_p.L281I|WHSC1_uc003geh.1_Missense_Mutation_p.L281I	NM_001042424	NP_001035889	O96028	NSD2_HUMAN	Wolf-Hirschhorn syndrome candidate 1 protein	281	PWWP 1.				anatomical structure morphogenesis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|cytoplasm|nuclear membrane|nucleolus	DNA binding|histone-lysine N-methyltransferase activity|zinc ion binding			ovary(3)|lung(3)|skin(2)|pancreas(1)	9		all_epithelial(65;1.34e-05)	OV - Ovarian serous cystadenocarcinoma(23;0.00606)	STAD - Stomach adenocarcinoma(129;0.232)		TGAGAAGAGCCTCGTAGCTTT	0.428		NaN	T	IGH@	MM								1	0	2.39556e-15	0.00278	2.50355e-15	23	82									
HAUS3	79441	broad.mit.edu	37	4	2238119	2238119	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr4:2238119C>G	uc003ges.1	-	4	1644	c.1414G>C	c.(1414-1416)GAG>CAG	p.E472Q	POLN_uc011bvi.1_Intron|HAUS3_uc011bvj.1_Missense_Mutation_p.E472Q|HAUS3_uc003get.1_Missense_Mutation_p.E472Q	NM_024511	NP_078787	Q68CZ6	HAUS3_HUMAN	HAUS augmin-like complex, subunit 3	472	Potential.				cell division|centrosome organization|mitosis|spindle assembly	centrosome|HAUS complex|microtubule|spindle				large_intestine(2)|breast(2)	4						GCCACTTCCTCAAGGTTTCCA	0.323		NaN											0	0	0	0.004007	0	16	121									
CCDC96	257236	broad.mit.edu	37	4	7044095	7044095	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr4:7044095G>A	uc003gjv.2	-	1	634	c.571C>T	c.(571-573)CCG>TCG	p.P191S	TADA2B_uc003gjw.3_5'Flank|TADA2B_uc010idi.2_5'Flank	NM_153376	NP_699207	Q2M329	CCD96_HUMAN	coiled-coil domain containing 96	191	Glu-rich.										0						CTTTTGGCCGGGCGTccttcc	0.403		NaN											0	0	0	0.00308	0	8	33									
CPZ	8532	broad.mit.edu	37	4	8602948	8602948	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr4:8602948G>A	uc003glm.2	+	3	346	c.220G>A	c.(220-222)GAG>AAG	p.E74K	CPZ_uc003gll.2_RNA|CPZ_uc003gln.2_5'UTR|CPZ_uc003glo.2_Missense_Mutation_p.E63K|CPZ_uc003glp.2_RNA	NM_001014447	NP_001014447	Q66K79	CBPZ_HUMAN	carboxypeptidase Z isoform 1	74	FZ.				proteolysis|Wnt receptor signaling pathway	proteinaceous extracellular matrix	metallocarboxypeptidase activity|zinc ion binding			ovary(2)|pancreas(1)	3						GGAGGTGGTGGAGGCCAGCTC	0.647		NaN											0	0	0	0.00308	0	8	23									
ARAP2	116984	broad.mit.edu	37	4	36212232	36212232	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr4:36212232G>A	uc003gsq.1	-	6	1605	c.1267C>T	c.(1267-1269)CAG>TAG	p.Q423*	ARAP2_uc003gsr.1_Nonsense_Mutation_p.Q423*	NM_015230	NP_056045	Q8WZ64	ARAP2_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH	423					regulation of ARF GTPase activity|small GTPase mediated signal transduction	cytosol	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|zinc ion binding			ovary(1)|pancreas(1)|skin(1)	3						CTTAAACTCTGAAAGCATTCT	0.368		NaN											0	0	0	0.01441	0	54	199									
UGDH	7358	broad.mit.edu	37	4	39506886	39506886	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr4:39506886G>A	uc003guk.1	-	9	1458	c.1142C>T	c.(1141-1143)TCT>TTT	p.S381F	UGDH_uc011byp.1_Missense_Mutation_p.S284F|UGDH_uc003gul.1_Missense_Mutation_p.S314F	NM_003359	NP_003350	O60701	UGDH_HUMAN	UDP-glucose dehydrogenase	381					glycosaminoglycan biosynthetic process|UDP-glucose metabolic process|UDP-glucuronate biosynthetic process|xenobiotic metabolic process	cytosol	electron carrier activity|NAD binding|UDP-glucose 6-dehydrogenase activity			large_intestine(1)|ovary(1)|central_nervous_system(1)|skin(1)	4					NADH(DB00157)	ACCTGGATGAGAAAGATCCAC	0.358		NaN											0	0	0	0.010504	0	20	111									
NSUN7	79730	broad.mit.edu	37	4	40763266	40763266	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr4:40763266G>C	uc003gvj.3	+	4	931	c.436G>C	c.(436-438)GAT>CAT	p.D146H	NSUN7_uc003gvh.2_Missense_Mutation_p.D146H|NSUN7_uc003gvi.3_Missense_Mutation_p.D146H	NM_024677	NP_078953			NOL1/NOP2/Sun domain family, member 7												0						TGTCCTTTCTGATAATGAAGA	0.323		NaN											0	0	0	0.008361	0	31	141									
TMPRSS11F	389208	broad.mit.edu	37	4	68934364	68934364	+	Silent	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr4:68934364G>A	uc003hdt.1	-	7	776	c.727C>T	c.(727-729)CTG>TTG	p.L243L	LOC550112_uc003hdl.3_Intron|uc011cak.1_Intron	NM_207407	NP_997290	Q6ZWK6	TM11F_HUMAN	transmembrane protease, serine 11F	243	Peptidase S1.|Extracellular (Potential).				proteolysis	extracellular region|integral to plasma membrane	serine-type endopeptidase activity			ovary(1)	1						GCTGTGAGCAGCCATGTGTTA	0.527		NaN											0	0	0	0.008291	0	9	76									
G3BP2	9908	broad.mit.edu	37	4	76579204	76579204	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr4:76579204G>A	uc003hir.2	-	8	953	c.788C>T	c.(787-789)TCT>TTT	p.S263F	G3BP2_uc003his.2_Missense_Mutation_p.S263F|G3BP2_uc003hit.2_Intron	NM_012297	NP_036429	Q9UN86	G3BP2_HUMAN	Ras-GTPase activating protein SH3 domain-binding	263					cytoplasmic sequestering of NF-kappaB|mRNA transport|Ras protein signal transduction|regulation of small GTPase mediated signal transduction	cytosol	GTPase activator activity|nucleotide binding|receptor signaling complex scaffold activity|RNA binding			breast(2)|central_nervous_system(1)	3			Lung(101;0.0973)|LUSC - Lung squamous cell carcinoma(112;0.122)			TGGAATTCCAGAGGAAGAAAC	0.423		NaN											0	0	0	0.008291	0	10	21									
FRAS1	80144	broad.mit.edu	37	4	79199890	79199890	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr4:79199890G>A	uc003hlb.2	+	10	1503	c.1063G>A	c.(1063-1065)GGA>AGA	p.G355R	FRAS1_uc003hkw.2_Missense_Mutation_p.G355R|FRAS1_uc003hky.1_Missense_Mutation_p.G59R|FRAS1_uc003hkz.2_Missense_Mutation_p.G59R	NM_025074	NP_079350	Q86XX4	FRAS1_HUMAN	Fraser syndrome 1	355	VWFC 6.|Extracellular (Potential).				cell communication	integral to membrane|plasma membrane	metal ion binding			large_intestine(5)	5						TGAAGAAACTGGAGAATTTGT	0.328		NaN											0	0	0	0.004007	0	17	43									
FRAS1	80144	broad.mit.edu	37	4	79238534	79238534	+	Nonsense_Mutation	SNP	C	C	G			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr4:79238534C>G	uc003hlb.2	+	17	2272	c.1832C>G	c.(1831-1833)TCA>TGA	p.S611*	FRAS1_uc003hkw.2_Nonsense_Mutation_p.S611*|FRAS1_uc003hky.1_Nonsense_Mutation_p.S315*|FRAS1_uc003hkz.2_Nonsense_Mutation_p.S315*|FRAS1_uc003hla.1_Nonsense_Mutation_p.S122*	NM_025074	NP_079350	Q86XX4	FRAS1_HUMAN	Fraser syndrome 1	611	FU 5.|Extracellular (Potential).				cell communication	integral to membrane|plasma membrane	metal ion binding			large_intestine(5)	5						TGTCATAACTCATGTGCCAGC	0.607		NaN											0	0	0	0.00499	0	16	83									
PTPN13	5783	broad.mit.edu	37	4	87691109	87691109	+	Silent	SNP	A	A	G			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr4:87691109A>G	uc003hpz.2	+	29	5157	c.4677A>G	c.(4675-4677)GGA>GGG	p.G1559G	PTPN13_uc003hpy.2_Silent_p.G1564G|PTPN13_uc003hqa.2_Silent_p.G1540G|PTPN13_uc003hqb.2_Silent_p.G1368G|PTPN13_uc003hqc.1_5'UTR	NM_080683	NP_542414	Q12923	PTN13_HUMAN	protein tyrosine phosphatase, non-receptor type	1559	PDZ 3.					cytoplasm|cytoskeleton|plasma membrane	protein binding|protein binding|protein tyrosine phosphatase activity			ovary(4)|breast(1)|kidney(1)	6		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.242)		OV - Ovarian serous cystadenocarcinoma(123;0.00082)		AAGTGAATGGAGCCTCTTTGA	0.408		NaN											0	0	0	0.00499	0	17	116									
DSPP	1834	broad.mit.edu	37	4	88535250	88535250	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr4:88535250C>T	uc003hqu.2	+	5	1556	c.1436C>T	c.(1435-1437)TCA>TTA	p.S479L		NM_014208	NP_055023	Q9NZW4	DSPP_HUMAN	dentin sialophosphoprotein preproprotein	479	Asp/Ser-rich.				biomineral tissue development|ossification|skeletal system development	proteinaceous extracellular matrix	calcium ion binding|collagen binding|extracellular matrix structural constituent			central_nervous_system(1)	1		Hepatocellular(203;0.114)|all_hematologic(202;0.236)		OV - Ovarian serous cystadenocarcinoma(123;0.000508)		GATGCTAATTCAGAAAGTGAC	0.378		NaN											0	0	0	0.00278	0	23	72									
PPP3CA	5530	broad.mit.edu	37	4	102117268	102117268	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr4:102117268G>T	uc011cen.1	-	2	739	c.64C>A	c.(64-66)CCA>ACA	p.P22T	PPP3CA_uc003hvu.2_Missense_Mutation_p.P22T|PPP3CA_uc010ilj.2_Missense_Mutation_p.P22T|PPP3CA_uc003hvt.2_Missense_Mutation_p.P9T|PPP3CA_uc003hvs.2_Intron|PPP3CA_uc010ilk.2_Missense_Mutation_p.P22T	NM_000944	NP_000935	Q08209	PP2BA_HUMAN	protein phosphatase 3, catalytic subunit, alpha	22	Catalytic.				protein dephosphorylation	calcineurin complex|cytosol|nucleus	calcium ion binding|calmodulin binding			ovary(1)|skin(1)	2				OV - Ovarian serous cystadenocarcinoma(123;6.79e-08)		GGAGGAAATGGAACAGCTGAA	0.383		NaN											1	0	0.00010058	0.013537	0.000102559	13	47									
AIMP1	9255	broad.mit.edu	37	4	107249297	107249297	+	Silent	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr4:107249297G>A	uc011cfg.1	+	4	340	c.288G>A	c.(286-288)GTG>GTA	p.V96V	AIMP1_uc003hyg.2_Silent_p.V96V|AIMP1_uc003hyh.2_Silent_p.V120V	NM_001142415	NP_001135887	Q12904	AIMP1_HUMAN	small inducible cytokine subfamily E, member 1	96	Interaction with HSP90B1 (By similarity).				angiogenesis|apoptosis|cell adhesion|cell-cell signaling|chemotaxis|glucose metabolic process|inflammatory response|leukocyte migration|negative regulation of endothelial cell proliferation|signal transduction|tRNA aminoacylation for protein translation	aminoacyl-tRNA synthetase multienzyme complex|cytosol|endoplasmic reticulum|extracellular space|Golgi apparatus|nucleus|transport vesicle	cell surface binding|cytokine activity|protein homodimerization activity|tRNA binding				0						CTGAAAATGTGATACAGTCTA	0.363		NaN											0	0	0	0.012319	0	22	65									
ENPEP	2028	broad.mit.edu	37	4	111397820	111397820	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr4:111397820G>A	uc003iab.3	+	1	592	c.250G>A	c.(250-252)GAG>AAG	p.E84K		NM_001977	NP_001968	Q07075	AMPE_HUMAN	glutamyl aminopeptidase	84	Extracellular (Potential).				cell migration|cell proliferation|cell-cell signaling|proteolysis	integral to plasma membrane	aminopeptidase activity|metalloexopeptidase activity|zinc ion binding			skin(3)|ovary(1)|breast(1)	5		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.0031)	L-Glutamic Acid(DB00142)	CAGTGAGGATGAGAGCGGACA	0.637		NaN											0	0	0	0.003954	0	26	51									
NDST4	64579	broad.mit.edu	37	4	115858492	115858492	+	Silent	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr4:115858492G>A	uc003ibu.2	-	5	2068	c.1389C>T	c.(1387-1389)TTC>TTT	p.F463F	NDST4_uc010imw.2_RNA	NM_022569	NP_072091	Q9H3R1	NDST4_HUMAN	heparan sulfate N-deacetylase/N-sulfotransferase	463	Lumenal (Potential).|Heparan sulfate N-deacetylase 4.					Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity			skin(3)|ovary(1)	4		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.000562)		TATTGTGAATGAAGCCCTTTC	0.438		NaN											0	0	0	0.014323	0	21	72									
TRPC3	7222	broad.mit.edu	37	4	122853440	122853440	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr4:122853440C>T	uc003ieg.2	-	2	1047	c.973G>A	c.(973-975)GAG>AAG	p.E325K	TRPC3_uc010inr.2_Missense_Mutation_p.E252K|TRPC3_uc003ief.2_Missense_Mutation_p.E252K|TRPC3_uc011cgl.1_5'UTR	NM_001130698	NP_001124170	Q13507	TRPC3_HUMAN	transient receptor potential cation channel,	240	Cytoplasmic (Potential).				axon guidance|phototransduction|platelet activation	integral to plasma membrane	protein binding|store-operated calcium channel activity			ovary(2)	2						AACTCCTTCTCTATGTTGGCC	0.627		NaN											0	0	0	0.008291	0	10	31									
NAA15	80155	broad.mit.edu	37	4	140275244	140275244	+	Missense_Mutation	SNP	A	A	G			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr4:140275244A>G	uc003ihu.1	+	10	1335	c.1079A>G	c.(1078-1080)AAC>AGC	p.N360S		NM_057175	NP_476516	Q9BXJ9	NAA15_HUMAN	NMDA receptor regulated 1	360					angiogenesis|cell differentiation|N-terminal protein amino acid acetylation|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|transcription factor complex	protein binding			ovary(1)|skin(1)	2						CGGTTATTTAACCCCAATGGT	0.318		NaN											0	0	0	0.007413	0	19	104									
NR3C2	4306	broad.mit.edu	37	4	149073701	149073701	+	Missense_Mutation	SNP	G	G	A	rs41511344		TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr4:149073701G>A	uc003ilj.3	-	6	2763	c.2429C>T	c.(2428-2430)TCA>TTA	p.S810L	NR3C2_uc003ilk.3_Missense_Mutation_p.S693L|NR3C2_uc010iph.2_Intron	NM_000901	NP_000892	P08235	MCR_HUMAN	nuclear receptor subfamily 3, group C, member 2	810	Steroid-binding.			S->M: Alters receptor specificity.	regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	endoplasmic reticulum membrane|nucleoplasm	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|zinc ion binding			large_intestine(1)	1	all_hematologic(180;0.151)			GBM - Glioblastoma multiforme(119;0.0614)	Desoxycorticosterone Pivalate(DB01134)|Eplerenone(DB00700)|Fludrocortisone(DB00687)|Spironolactone(DB00421)	GGCAAATGATGATAGACACAT	0.353		NaN											0	0	0	0.003163	0	15	59									
FGA	2243	broad.mit.edu	37	4	155507934	155507934	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr4:155507934C>T	uc003iod.1	-	5	705	c.647G>A	c.(646-648)AGA>AAA	p.R216K	FGA_uc003ioe.1_Missense_Mutation_p.R216K|FGA_uc003iof.1_Intron	NM_000508	NP_000499	P02671	FIBA_HUMAN	fibrinogen, alpha polypeptide isoform alpha-E	216	By similarity.			SR -> RS (in Ref. 9; AA sequence).	platelet activation|platelet degranulation|protein polymerization|response to calcium ion|signal transduction	external side of plasma membrane|fibrinogen complex|platelet alpha granule lumen	eukaryotic cell surface binding|protein binding, bridging|receptor binding			ovary(2)|breast(1)	3	all_hematologic(180;0.215)	Renal(120;0.0458)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Sucralfate(DB00364)|Tenecteplase(DB00031)	TTGCCTATCTCTAGAGGGAAG	0.448		NaN											0	0	0	0.009535	0	30	119									
HMGB2	3148	broad.mit.edu	37	4	174254236	174254236	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr4:174254236C>A	uc011ckc.1	-	2	400	c.280G>T	c.(280-282)GCT>TCT	p.A94S	HMGB2_uc003ita.3_Missense_Mutation_p.A94S|HMGB2_uc003itb.2_Missense_Mutation_p.A94S|HMGB2_uc003itc.2_Missense_Mutation_p.A94S	NM_001130689	NP_001124161	P26583	HMGB2_HUMAN	high-mobility group box 2	94					base-excision repair, DNA ligation|cell chemotaxis|cellular response to lipopolysaccharide|DNA fragmentation involved in apoptotic nuclear change|DNA topological change|negative regulation of transcription, DNA-dependent|nucleosome assembly|phosphatidylinositol-mediated signaling|positive regulation of DNA binding|positive regulation of endothelial cell proliferation|positive regulation of erythrocyte differentiation|positive regulation of megakaryocyte differentiation|positive regulation of nuclease activity|positive regulation of transcription from RNA polymerase II promoter|V(D)J recombination	condensed chromosome|extracellular space|nucleolus|nucleoplasm|perinuclear region of cytoplasm|protein complex	chemoattractant activity|damaged DNA binding|DNA bending activity|double-stranded DNA binding|RAGE receptor binding|sequence-specific DNA binding transcription factor activity|single-stranded DNA binding|transcription regulatory region DNA binding				0		Prostate(90;0.0132)|Renal(120;0.0183)|Melanoma(52;0.0749)|all_hematologic(60;0.107)|all_neural(102;0.122)		all cancers(43;9.58e-18)|Epithelial(43;3.75e-16)|OV - Ovarian serous cystadenocarcinoma(60;6.24e-09)|STAD - Stomach adenocarcinoma(60;0.00273)|GBM - Glioblastoma multiforme(59;0.0064)|LUSC - Lung squamous cell carcinoma(193;0.0903)|Kidney(143;0.249)		CTTTTAGGAGCATTGGGGTCC	0.403		NaN											1	0	6.34439e-16	0.01441	6.63825e-16	46	250									
PDLIM3	27295	broad.mit.edu	37	4	186429463	186429463	+	Missense_Mutation	SNP	G	G	A	rs150809809		TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr4:186429463G>A	uc003ixw.3	-	5	776	c.652C>T	c.(652-654)CCT>TCT	p.P218S	PDLIM3_uc003ixx.3_Intron|PDLIM3_uc010isi.2_Intron	NM_014476	NP_055291	Q53GG5	PDLI3_HUMAN	PDZ and LIM domain protein 3 isoform a	218						sarcomere	zinc ion binding			ovary(2)	2		all_lung(41;1.03e-13)|Lung NSC(41;2.49e-13)|Melanoma(20;1.91e-06)|Hepatocellular(41;0.00826)|Renal(120;0.00988)|Prostate(90;0.00996)|Colorectal(36;0.0161)|all_hematologic(60;0.0592)|all_neural(102;0.243)		OV - Ovarian serous cystadenocarcinoma(60;1.4e-10)|BRCA - Breast invasive adenocarcinoma(30;8.64e-05)|GBM - Glioblastoma multiforme(59;0.000167)|STAD - Stomach adenocarcinoma(60;0.000828)|LUSC - Lung squamous cell carcinoma(40;0.00984)|COAD - Colon adenocarcinoma(29;0.0115)|READ - Rectum adenocarcinoma(43;0.171)		CTCATCAAAGGTGTTTCCCCT	0.403		NaN											0	0	0	0.009718	0	39	151									
DNAH5	1767	broad.mit.edu	37	5	13841027	13841027	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr5:13841027G>C	uc003jfd.2	-	34	5739	c.5697C>G	c.(5695-5697)ATC>ATG	p.I1899M		NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	1899	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					GGTCATCAAAGATATCCCTTT	0.383		NaN							Kartagener_syndrome				0	0	0	0.008871	0	19	106									
TRIO	7204	broad.mit.edu	37	5	14389431	14389431	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr5:14389431G>A	uc003jff.2	+	25	3988	c.3982G>A	c.(3982-3984)GAG>AAG	p.E1328K	TRIO_uc003jfg.2_RNA|TRIO_uc011cna.1_Missense_Mutation_p.E1279K|TRIO_uc003jfh.1_Missense_Mutation_p.E977K	NM_007118	NP_009049	O75962	TRIO_HUMAN	triple functional domain (PTPRF interacting)	1328	DH 1.				apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|transmembrane receptor protein tyrosine phosphatase signaling pathway	cytosol	ATP binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			skin(4)|central_nervous_system(3)|ovary(3)|large_intestine(2)|stomach(2)|breast(2)|upper_aerodigestive_tract(1)|kidney(1)	18	Lung NSC(4;0.000742)					TGGCGTGGAAGAGATTCCACC	0.413		NaN											0	0	0	0.003163	0	12	30									
FBXL7	23194	broad.mit.edu	37	5	15928098	15928098	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr5:15928098C>T	uc003jfn.1	+	3	708	c.227C>T	c.(226-228)TCC>TTC	p.S76F		NM_012304	NP_036436	Q9UJT9	FBXL7_HUMAN	F-box and leucine-rich repeat protein 7	76					ubiquitin-dependent protein catabolic process	ubiquitin ligase complex	protein binding|ubiquitin-protein ligase activity			ovary(2)|lung(1)	3						TCGTCCACCTCCTCGTCCTCC	0.657		NaN											0	0	0	0.00245	0	14	35									
MYO10	4651	broad.mit.edu	37	5	16781865	16781865	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr5:16781865G>C	uc003jft.3	-	6	1144	c.676C>G	c.(676-678)CAG>GAG	p.Q226E	MYO10_uc003jfu.2_Missense_Mutation_p.Q193E	NM_012334	NP_036466	Q9HD67	MYO10_HUMAN	myosin X	226	Myosin head-like.				axon guidance|signal transduction	myosin complex	actin binding|ATP binding|motor activity			ovary(2)|pancreas(1)	3						ATGTTCAGCTGAACAAACTTC	0.423		NaN											0	0	0	0.00245	0	14	95									
MTMR12	54545	broad.mit.edu	37	5	32233926	32233926	+	Nonsense_Mutation	SNP	C	C	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr5:32233926C>A	uc003jhq.2	-	15	1797	c.1627G>T	c.(1627-1629)GAA>TAA	p.E543*	MTMR12_uc010iuk.2_Intron|MTMR12_uc010iul.2_Intron	NM_001040446	NP_001035536	Q9C0I1	MTMRC_HUMAN	myotubularin related protein 12	543	Myotubularin phosphatase.|Interaction with MTM1.					cytoplasm	phosphatase activity			ovary(1)	1						TTTGGCTTTTCCACATAAAGA	0.493		NaN											1	0	1.60974e-12	0.01441	1.67832e-12	52	126									
ADAMTS12	81792	broad.mit.edu	37	5	33891861	33891861	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr5:33891861G>A	uc003jia.1	-	1	264	c.101C>T	c.(100-102)CCG>CTG	p.P34L	ADAMTS12_uc010iuq.1_Missense_Mutation_p.P34L|ADAMTS12_uc003jib.1_Missense_Mutation_p.P34L	NM_030955	NP_112217	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1	34					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|kidney(1)	9						GAAGCGAACCGGGCCTGGCTG	0.527		NaN								HNSCC(64;0.19)			0	0	0	0.01441	0	42	133									
TTC23L	153657	broad.mit.edu	37	5	34867123	34867123	+	Silent	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr5:34867123G>A	uc003jiu.2	+	7	892	c.789G>A	c.(787-789)CAG>CAA	p.Q263Q	TTC23L_uc003jiv.2_Silent_p.Q70Q|TTC23L_uc010iut.1_Silent_p.Q70Q	NM_144725	NP_653326	Q6PF05	TT23L_HUMAN	tetratricopeptide repeat domain 23-like	263	Potential.						binding			central_nervous_system(1)	1						AAGCTGCTCAGATAGAGCAGC	0.547		NaN											0	0	0	0.001168	0	5	17									
RANBP3L	202151	broad.mit.edu	37	5	36265572	36265572	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr5:36265572C>T	uc003jkh.2	-	5	812	c.319G>A	c.(319-321)GAT>AAT	p.D107N	RANBP3L_uc011cow.1_Missense_Mutation_p.D132N	NM_145000	NP_659437	Q86VV4	RNB3L_HUMAN	RAN binding protein 3-like isoform 2	107					intracellular transport					ovary(1)	1	all_lung(31;4.52e-05)		Epithelial(62;0.0543)|Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|all cancers(62;0.149)|Colorectal(62;0.202)			CTCTTTATATCAACACTACTT	0.308		NaN											0	0	0	0.013726	0	32	101									
TTC33	23548	broad.mit.edu	37	5	40730373	40730373	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr5:40730373C>T	uc003jma.2	-	3	442	c.294G>A	c.(292-294)ATG>ATA	p.M98I	TTC33_uc011cpm.1_Intron|TTC33_uc010ivg.2_Intron	NM_012382	NP_036514	Q6PID6	TTC33_HUMAN	tetratricopeptide repeat domain 33	98	TPR 2.						binding			ovary(1)	1						CCTGTGATTTCATCTCGTATA	0.368		NaN											0	0	0	0.01441	0	46	119									
HCN1	348980	broad.mit.edu	37	5	45462008	45462008	+	Silent	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr5:45462008G>A	uc003jok.2	-	3	976	c.951C>T	c.(949-951)TTC>TTT	p.F317F		NM_021072	NP_066550	O60741	HCN1_HUMAN	hyperpolarization activated cyclic	317	Helical; Name=Segment S5; (Potential).					integral to membrane	cAMP binding|sodium channel activity|voltage-gated potassium channel activity			ovary(1)	1						GTGGTACTAAGAACTGAAGAC	0.423		NaN											0	0	0	0.004007	0	16	64									
AP3B1	8546	broad.mit.edu	37	5	77406125	77406125	+	Nonsense_Mutation	SNP	G	G	C			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr5:77406125G>C	uc003kfj.2	-	20	2428	c.2303C>G	c.(2302-2304)TCA>TGA	p.S768*		NM_003664	NP_003655	O00203	AP3B1_HUMAN	adaptor-related protein complex 3, beta 1	768	Glu/Ser-rich.				endocytosis|melanosome organization	clathrin coated vesicle membrane|Golgi apparatus|membrane coat	protein phosphatase binding|protein transporter activity			central_nervous_system(1)	1		all_lung(232;0.000397)|Lung NSC(167;0.00106)|Ovarian(174;0.0105)|Prostate(461;0.215)		OV - Ovarian serous cystadenocarcinoma(54;8.23e-47)|Epithelial(54;2.74e-41)|all cancers(79;4.8e-36)		TTCGTCATTTGAAGAATCTGA	0.328		NaN							Hermansky-Pudlak_syndrome				0	0	0	0.00308	0	8	38									
MTX3	345778	broad.mit.edu	37	5	79284998	79284998	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr5:79284998C>T	uc010jag.2	-	4	325	c.298G>A	c.(298-300)GAA>AAA	p.E100K	MTX3_uc010jah.2_Missense_Mutation_p.E100K|MTX3_uc003kge.3_Missense_Mutation_p.E39K|MTX3_uc003kgf.1_5'Flank	NM_001010891	NP_001010891	Q5HYI7	MTX3_HUMAN	metaxin 3	100					protein targeting to mitochondrion	mitochondrial outer membrane					0		Lung NSC(167;0.00428)|all_lung(232;0.00455)|Ovarian(174;0.0261)		OV - Ovarian serous cystadenocarcinoma(54;1.63e-45)|Epithelial(54;2.9e-40)|all cancers(79;4.68e-35)		AGCTTCTCTTCGAGGAGAGCA	0.338		NaN											0	0	0	0.006214	0	8	14									
GPR98	84059	broad.mit.edu	37	5	90052949	90052949	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr5:90052949C>T	uc003kju.2	+	57	12007	c.11911C>T	c.(11911-11913)CAT>TAT	p.H3971Y	GPR98_uc003kjt.2_Missense_Mutation_p.H1677Y|GPR98_uc003kjv.2_Missense_Mutation_p.H1571Y	NM_032119	NP_115495	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98 precursor	3971	Calx-beta 26.|Extracellular (Potential).				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(11)|central_nervous_system(3)|pancreas(2)	16		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		TAAACCATCTCATGGGATTCT	0.423		NaN											0	0	0	0.012319	0	22	49									
FAM81B	153643	broad.mit.edu	37	5	94728542	94728542	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr5:94728542G>A	uc003kla.1	+	2	215	c.169G>A	c.(169-171)GAA>AAA	p.E57K	FAM81B_uc010jbe.1_5'UTR	NM_152548	NP_689761	Q96LP2	FA81B_HUMAN	hypothetical protein LOC153643	57										ovary(1)|skin(1)	2		all_cancers(142;1.1e-06)|all_epithelial(76;1.48e-09)|all_lung(232;0.000696)|Lung NSC(167;0.000947)|Ovarian(225;0.00473)		all cancers(79;1.04e-16)		GACTGCAGAGGAACAGCCAGT	0.403		NaN											0	0	0	0.006122	0	13	21									
GIN1	54826	broad.mit.edu	37	5	102442447	102442447	+	Silent	SNP	T	T	C			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr5:102442447T>C	uc003koa.1	-	3	388	c.306A>G	c.(304-306)ACA>ACG	p.T102T	GIN1_uc003kob.1_Intron|GIN1_uc003koc.1_Silent_p.T102T	NM_017676	NP_060146	Q9NXP7	GIN1_HUMAN	zinc finger, H2C2 domain containing	102					DNA integration		DNA binding			ovary(1)|skin(1)	2		all_cancers(142;3.23e-07)|all_epithelial(76;3.64e-10)|Prostate(80;0.00914)|Ovarian(225;0.0139)|Lung NSC(167;0.0212)|Colorectal(57;0.0249)|all_lung(232;0.0283)		Epithelial(69;3.57e-14)|COAD - Colon adenocarcinoma(37;0.00794)		TGGTCACAGATGTCCAATAAT	0.338		NaN											0	0	0	0.00499	0	17	35									
C5orf48	389320	broad.mit.edu	37	5	125968328	125968328	+	Silent	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr5:125968328C>T	uc003kub.1	+	2	190	c.177C>T	c.(175-177)TTC>TTT	p.F59F		NM_207408	NP_997291	Q6ZNM6	CE048_HUMAN	hypothetical protein LOC389320	59										ovary(1)	1						ACATGATATTCAGGAATGTGA	0.289		NaN											0	0	0	0.001855	0	14	47									
RAD50	10111	broad.mit.edu	37	5	131895051	131895051	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr5:131895051G>A	uc003kxi.2	+	2	592	c.205G>A	c.(205-207)GAT>AAT	p.D69N	RAD50_uc003kxg.1_5'UTR|RAD50_uc003kxh.2_5'UTR	NM_005732	NP_005723	Q92878	RAD50_HUMAN	RAD50 homolog isoform 1	69					DNA duplex unwinding|double-strand break repair via homologous recombination|positive regulation of kinase activity|positive regulation of protein autophosphorylation|reciprocal meiotic recombination|regulation of mitotic recombination|telomere maintenance via telomerase	Mre11 complex|nuclear chromosome, telomeric region|nucleoplasm	ATP binding|DNA binding|nuclease activity|protein binding, bridging|zinc ion binding			lung(2)|ovary(1)|skin(1)	4		all_cancers(142;0.0368)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			ATTTGTACACGATCCCAAGGT	0.214		NaN						Homologous_recombination					0	0	0	0.012319	0	22	81									
CATSPER3	347732	broad.mit.edu	37	5	134332199	134332199	+	Silent	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr5:134332199C>T	uc003lag.2	+	3	557	c.489C>T	c.(487-489)ATC>ATT	p.I163I		NM_178019	NP_821138	Q86XQ3	CTSR3_HUMAN	cation channel, sperm associated 3	163	Cytoplasmic (Potential).				cell differentiation|multicellular organismal development|spermatogenesis	cilium|flagellar membrane|integral to membrane	calcium channel activity|voltage-gated ion channel activity			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			GCCAGGGCATCCGGGTGAGTG	0.547		NaN											0	0	0	0.010504	0	17	66									
H2AFY	9555	broad.mit.edu	37	5	134705752	134705752	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr5:134705752C>T	uc003lam.1	-	3	463	c.253G>A	c.(253-255)GTG>ATG	p.V85M	H2AFY_uc003lao.1_Missense_Mutation_p.V85M|H2AFY_uc003lan.1_Missense_Mutation_p.V85M|H2AFY_uc003lap.1_RNA|H2AFY_uc003laq.1_RNA|H2AFY_uc003lar.1_RNA|H2AFY_uc011cxz.1_Intron|H2AFY_uc003las.1_Missense_Mutation_p.V85M|H2AFY_uc003lat.1_Missense_Mutation_p.V85M	NM_138610	NP_613258	O75367	H2AY_HUMAN	H2A histone family, member Y isoform 3	85	Histone H2A.				chromatin modification|dosage compensation|nucleosome assembly	Barr body|nucleosome	DNA binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			TCATTGGCCACAGCCAGCAGG	0.562		NaN											0	0	0	0.009096	0	3	29									
MYOT	9499	broad.mit.edu	37	5	137219160	137219160	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr5:137219160G>C	uc011cye.1	+	7	921	c.904G>C	c.(904-906)GAG>CAG	p.E302Q	MYOT_uc003lbv.2_Missense_Mutation_p.E302Q|MYOT_uc011cyg.1_Missense_Mutation_p.E118Q|MYOT_uc011cyh.1_Missense_Mutation_p.E187Q	NM_001135940	NP_001129412	Q9UBF9	MYOTI_HUMAN	myotilin isoform b	302	Necessary for interaction with ACTA1.|Ig-like C2-type 1.|Necessary for interaction with FLNC.				muscle contraction	actin cytoskeleton|sarcolemma|sarcomere	actin binding|structural constituent of muscle			large_intestine(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0109)			GATAGTGTCTGAGAAGGGTCT	0.433		NaN											0	0	0	0.00333	0	25	88									
KDM3B	51780	broad.mit.edu	37	5	137763715	137763715	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr5:137763715G>C	uc003lcy.1	+	20	4893	c.4693G>C	c.(4693-4695)GAT>CAT	p.D1565H	KDM3B_uc010jew.1_Missense_Mutation_p.D1221H|KDM3B_uc011cys.1_Missense_Mutation_p.D597H	NM_016604	NP_057688	Q7LBC6	KDM3B_HUMAN	jumonji domain containing 1B	1565	JmjC.				chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			ovary(3)|upper_aerodigestive_tract(2)|lung(2)|kidney(2)|central_nervous_system(1)|skin(1)	11						AGATGTGTCTGATGCTGTTAA	0.428		NaN											0	0	0	0.01441	0	67	277									
PCDHB8	56128	broad.mit.edu	37	5	140559208	140559208	+	Silent	SNP	G	G	C			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr5:140559208G>C	uc011dai.1	+	1	1779	c.1593G>C	c.(1591-1593)CGG>CGC	p.R531R	PCDHB16_uc003liv.2_5'Flank|PCDHB16_uc010jfw.1_5'Flank	NM_019120	NP_061993	Q9UN66	PCDB8_HUMAN	protocadherin beta 8 precursor	531	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			skin(4)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TCGAGTTCCGGGTGGGCGCTT	0.672		NaN											0	0	0	0.004007	0	11	108									
PCDHB16	57717	broad.mit.edu	37	5	140563854	140563854	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr5:140563854G>A	uc003liv.2	+	1	2875	c.1720G>A	c.(1720-1722)GAG>AAG	p.E574K		NM_020957	NP_066008	Q9NRJ7	PCDBG_HUMAN	protocadherin beta 16 precursor	574	Cadherin 6.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			ovary(1)|pancreas(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GCCCTGCACTGAGCTGGTGCC	0.692		NaN											0	0	0	0.006214	0	9	32									
PCDHB10	56126	broad.mit.edu	37	5	140573268	140573268	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr5:140573268G>A	uc003lix.2	+	1	1317	c.1143G>A	c.(1141-1143)ATG>ATA	p.M381I		NM_018930	NP_061753	Q9UN67	PCDBA_HUMAN	protocadherin beta 10 precursor	381	Cadherin 4.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			ovary(1)|skin(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			ATGGAAAGATGGTTTGCTACA	0.418		NaN											0	0	0	0.00499	0	18	56									
PCDHGC5	56097	broad.mit.edu	37	5	140870243	140870243	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr5:140870243C>T	uc003lla.1	+	1	1436	c.1436C>T	c.(1435-1437)TCA>TTA	p.S479L	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc003lkh.1_Intron|PCDHGB6_uc003lkj.1_Intron|PCDHGA10_uc003lkl.1_Intron|PCDHGB7_uc003lkn.1_Intron|PCDHGA11_uc003lkp.1_Intron|PCDHGA11_uc003lkq.1_Intron|PCDHGA12_uc003lkt.1_Intron|PCDHGC3_uc003lkv.1_Intron|PCDHGC3_uc003lkw.1_Intron|PCDHGC4_uc003lky.1_Intron|PCDHGC5_uc011dbc.1_Missense_Mutation_p.S479L	NM_018929	NP_061752	Q9Y5F6	PCDGM_HUMAN	protocadherin gamma subfamily C, 5 isoform 1	479	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GTGGCTGCCTCAGATCCAGAC	0.542		NaN											0	0	0	0.013726	0	33	116									
FBXO38	81545	broad.mit.edu	37	5	147807414	147807414	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr5:147807414G>A	uc003lpf.1	+	15	2677	c.2557G>A	c.(2557-2559)GAG>AAG	p.E853K	FBXO38_uc003lpg.1_Intron|FBXO38_uc003lph.2_Intron	NM_205836	NP_995308	Q6PIJ6	FBX38_HUMAN	F-box protein 38 isoform b	853						cytoplasm|nucleus				ovary(4)|skin(2)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTCCCAGCCTGAGAGTTGTGA	0.582		NaN											0	0	0	0.001168	0	6	31									
CSF1R	1436	broad.mit.edu	37	5	149449619	149449619	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr5:149449619C>T	uc003lrl.2	-	9	1522	c.1327G>A	c.(1327-1329)GAG>AAG	p.E443K	CSF1R_uc011dcd.1_Missense_Mutation_p.E295K|CSF1R_uc010jhc.2_RNA|CSF1R_uc003lrm.2_Missense_Mutation_p.E443K	NM_005211	NP_005202	P07333	CSF1R_HUMAN	colony stimulating factor 1 receptor precursor	443	Ig-like C2-type 5.|Extracellular (Potential).				cell proliferation|multicellular organismal development|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane|receptor complex	ATP binding|cytokine binding|macrophage colony-stimulating factor receptor activity|protein homodimerization activity			haematopoietic_and_lymphoid_tissue(38)|lung(6)|central_nervous_system(3)|liver(3)|breast(2)|endometrium(1)|ovary(1)	54			KIRC - Kidney renal clear cell carcinoma(527;0.000962)|Kidney(363;0.00147)		Imatinib(DB00619)|Sunitinib(DB01268)	ACTTGGGCCTCATCACACCTG	0.617		NaN											0	0	0	0.004482	0	8	36									
FAM114A2	10827	broad.mit.edu	37	5	153407773	153407773	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr5:153407773G>A	uc003lvb.2	-	6	1154	c.566C>T	c.(565-567)GCA>GTA	p.A189V	FAM114A2_uc003lvc.2_Missense_Mutation_p.A189V|FAM114A2_uc003lvd.2_Missense_Mutation_p.A189V|FAM114A2_uc003lve.2_Missense_Mutation_p.A5V|FAM114A2_uc011dda.1_Missense_Mutation_p.A119V	NM_018691	NP_061161	Q9NRY5	F1142_HUMAN	hypothetical protein LOC10827	189							purine nucleotide binding				0						ATCCCCTTCTGCTATCACATC	0.393		NaN											0	0	0	0.004878	0	36	88									
ADAM19	8728	broad.mit.edu	37	5	156932736	156932736	+	Silent	SNP	A	A	G			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr5:156932736A>G	uc003lwz.2	-	11	1135	c.1071T>C	c.(1069-1071)TCT>TCC	p.S357S	ADAM19_uc003lww.1_Silent_p.S90S|ADAM19_uc003lwy.2_5'Flank|ADAM19_uc011ddr.1_Silent_p.S288S	NM_033274	NP_150377	Q9H013	ADA19_HUMAN	ADAM metallopeptidase domain 19 preproprotein	357	Peptidase M12B.|Extracellular (Potential).				proteolysis	integral to membrane	metalloendopeptidase activity|SH3 domain binding|zinc ion binding			ovary(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)|skin(1)	8	Renal(175;0.00488)	Medulloblastoma(196;0.0359)|all_neural(177;0.14)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			AGCAATCTGCAGAATCATGGG	0.602		NaN											0	0	0	0.001984	0	6	18									
SOX30	11063	broad.mit.edu	37	5	157078609	157078609	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr5:157078609G>A	uc003lxb.1	-	1	820	c.478C>T	c.(478-480)CCT>TCT	p.P160S	SOX30_uc003lxc.1_Missense_Mutation_p.P160S|SOX30_uc011dds.1_Intron	NM_178424	NP_848511	O94993	SOX30_HUMAN	SRY (sex determining region Y)-box 30 isoform a	160					regulation of transcription from RNA polymerase II promoter|regulation of transcription, DNA-dependent|response to corticosteroid stimulus|transcription, DNA-dependent	nucleus|nucleus	sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity			ovary(1)|central_nervous_system(1)	2	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.138)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			GAGGCTCTAGGACCGGTTTCG	0.677		NaN											0	0	0	0.001168	0	5	27									
CLINT1	9685	broad.mit.edu	37	5	157218935	157218935	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr5:157218935C>T	uc003lxj.1	-	10	1346	c.1156G>A	c.(1156-1158)GTT>ATT	p.V386I	CLINT1_uc003lxg.1_5'Flank|CLINT1_uc003lxh.1_5'UTR|CLINT1_uc003lxi.1_Missense_Mutation_p.V368I|CLINT1_uc011ddv.1_Missense_Mutation_p.V386I	NM_014666	NP_055481	Q14677	EPN4_HUMAN	epsin 4	386					endocytosis|post-Golgi vesicle-mediated transport	clathrin-coated vesicle|cytosol|Golgi apparatus|membrane|perinuclear region of cytoplasm	clathrin binding|lipid binding			ovary(2)|pancreas(1)	3	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.138)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			CTGGAAGCAACAGGGCCTGAT	0.512		NaN											0	0	0	0.008291	0	8	46									
GABRB2	2561	broad.mit.edu	37	5	160761889	160761889	+	Silent	SNP	G	G	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr5:160761889G>T	uc003lys.1	-	8	920	c.702C>A	c.(700-702)CTC>CTA	p.L234L	GABRB2_uc011deh.1_Silent_p.L73L|GABRB2_uc003lyr.1_Silent_p.L234L|GABRB2_uc003lyt.1_Silent_p.L234L|GABRB2_uc010jiu.1_Silent_p.L171L	NM_021911	NP_068711	P47870	GBRB2_HUMAN	gamma-aminobutyric acid (GABA) A receptor, beta	234	Extracellular (Probable).				gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|GABA-A receptor activity				0	Renal(175;0.00259)	Medulloblastoma(196;0.021)|all_neural(177;0.0463)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)		Ethchlorvynol(DB00189)|Flurazepam(DB00690)|Lorazepam(DB00186)|Midazolam(DB00683)	GCTTAAAGCTGAGGGATAACC	0.368		NaN											1	0	1.02788e-11	0.00499	1.06788e-11	16	54									
PANK3	79646	broad.mit.edu	37	5	167993164	167993164	+	Silent	SNP	A	A	G			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr5:167993164A>G	uc003lzz.1	-	3	789	c.489T>C	c.(487-489)TTT>TTC	p.F163F		NM_024594	NP_078870	Q9H999	PANK3_HUMAN	pantothenate kinase 3	163					coenzyme A biosynthetic process	cytoplasm|nucleus	ATP binding|pantothenate kinase activity			ovary(1)	1	Renal(175;0.000159)|Lung NSC(126;0.0441)|all_lung(126;0.0909)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0989)|OV - Ovarian serous cystadenocarcinoma(192;0.147)|Epithelial(171;0.188)		AGGCATTAGCAAAATAATAGC	0.448		NaN											0	0	0	0.00632	0	28	155									
CDHR2	54825	broad.mit.edu	37	5	176005373	176005373	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr5:176005373C>T	uc003mem.1	+	16	1648	c.1582C>T	c.(1582-1584)CTC>TTC	p.L528F	CDHR2_uc003men.1_Missense_Mutation_p.L528F	NM_017675	NP_060145	Q9BYE9	CDHR2_HUMAN	protocadherin LKC precursor	528	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion|negative regulation of cell growth	apical plasma membrane|cell junction|integral to membrane	calcium ion binding|protein binding			ovary(2)	2						CAGGGCAGACCTCTTCCAAGT	0.388		NaN											0	0	0	0.000602	0	4	8									
CAGE1	285782	broad.mit.edu	37	6	7373335	7373335	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr6:7373335C>G	uc003mxi.2	-	4	2030	c.1309G>C	c.(1309-1311)GAG>CAG	p.E437Q	CAGE1_uc003mxh.2_RNA|CAGE1_uc003mxj.2_Missense_Mutation_p.E328Q|CAGE1_uc003mxk.1_Missense_Mutation_p.E328Q	NM_205864	NP_995586	Q8TC20	CAGE1_HUMAN	cancer antigen 1	573											0	Ovarian(93;0.0418)					AAGACTTCCTCTAATTGATCC	0.348		NaN											0	0	0	0.001984	0	7	59									
DSP	1832	broad.mit.edu	37	6	7580702	7580702	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr6:7580702G>A	uc003mxp.1	+	23	4558	c.4279G>A	c.(4279-4281)GAA>AAA	p.E1427K	DSP_uc003mxq.1_Intron	NM_004415	NP_004406	P15924	DESP_HUMAN	desmoplakin isoform I	1427	Central fibrous rod domain.|Potential.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			central_nervous_system(6)|ovary(2)|skin(1)	9	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		CAGGAGGGTGGAAGAAGACAT	0.483		NaN											0	0	0	0.010729	0	11	58									
DSP	1832	broad.mit.edu	37	6	7581076	7581076	+	Silent	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr6:7581076G>A	uc003mxp.1	+	23	4932	c.4653G>A	c.(4651-4653)GTG>GTA	p.V1551V	DSP_uc003mxq.1_Intron	NM_004415	NP_004406	P15924	DESP_HUMAN	desmoplakin isoform I	1551	Central fibrous rod domain.|Potential.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			central_nervous_system(6)|ovary(2)|skin(1)	9	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		AGAGGACTGTGAAGGACCAGG	0.522		NaN											0	0	0	0.01441	0	47	80									
TXNDC5	81567	broad.mit.edu	37	6	8064557	8064557	+	Translation_Start_Site	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr6:8064557C>T	uc003mxw.2	-	1	91	c.-197G>A	c.(-199--195)CGGTG>CGATG		MUTED_uc003mxy.2_Missense_Mutation_p.G18D|MUTED_uc010joc.2_Translation_Start_Site|MUTED_uc010job.2_RNA	NM_001145549	NP_001139021	Q8NBS9	TXND5_HUMAN	thioredoxin domain containing 5 isoform 3						anti-apoptosis|cell redox homeostasis|cellular membrane organization|glycerol ether metabolic process|post-Golgi vesicle-mediated transport	endoplasmic reticulum lumen|lysosomal lumen	electron carrier activity|isomerase activity|protein disulfide oxidoreductase activity				0	Ovarian(93;0.0398)					CTTGCTGCCACCGCCCGGGGC	0.667		NaN											0	0	0	0.00308	0	8	19									
SYCP2L	221711	broad.mit.edu	37	6	10913109	10913109	+	Missense_Mutation	SNP	T	T	C			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr6:10913109T>C	uc003mzo.2	+	14	1317	c.1021T>C	c.(1021-1023)TGG>CGG	p.W341R	SYCP2L_uc011din.1_Missense_Mutation_p.W182R|SYCP2L_uc010jow.2_5'UTR	NM_001040274	NP_001035364	Q5T4T6	SYC2L_HUMAN	synaptonemal complex protein 2-like	341						nucleus				ovary(1)|skin(1)	2	Breast(50;0.0838)|Ovarian(93;0.107)	all_hematologic(90;0.135)	Epithelial(50;0.239)			GAATACTCTATGGGACTCAGT	0.348		NaN											0	0	0	0.00632	0	29	53									
NHLRC1	378884	broad.mit.edu	37	6	18122174	18122174	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr6:18122174C>G	uc003ncl.1	-	1	678	c.664G>C	c.(664-666)GAG>CAG	p.E222Q		NM_198586	NP_940988	Q6VVB1	NHLC1_HUMAN	NHL repeat containing 1	222	NHL 3.				proteasomal ubiquitin-dependent protein catabolic process|protein polyubiquitination	endoplasmic reticulum|nucleus	protein binding|ubiquitin-protein ligase activity|zinc ion binding				0	Ovarian(93;0.016)|Breast(50;0.0245)	all_hematologic(90;0.165)	all cancers(50;0.0451)|Epithelial(50;0.0493)			GGGGTGGTCTCCACACCCCAA	0.552		NaN											0	0	0	0.010729	0	12	22									
NHLRC1	378884	broad.mit.edu	37	6	18122786	18122786	+	Nonsense_Mutation	SNP	C	C	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr6:18122786C>A	uc003ncl.1	-	1	66	c.52G>T	c.(52-54)GAG>TAG	p.E18*		NM_198586	NP_940988	Q6VVB1	NHLC1_HUMAN	NHL repeat containing 1	18					proteasomal ubiquitin-dependent protein catabolic process|protein polyubiquitination	endoplasmic reticulum|nucleus	protein binding|ubiquitin-protein ligase activity|zinc ion binding				0	Ovarian(93;0.016)|Breast(50;0.0245)	all_hematologic(90;0.165)	all cancers(50;0.0451)|Epithelial(50;0.0493)			ATCTCCGCCTCGCGCATGAGC	0.711		NaN											1	0	0.00909568	0.009096	0.00917903	4	17									
BTN3A3	10384	broad.mit.edu	37	6	26446154	26446154	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr6:26446154C>T	uc003nhz.2	+	5	836	c.656C>T	c.(655-657)TCC>TTC	p.S219F	BTN3A3_uc003nia.2_Missense_Mutation_p.S177F|BTN3A3_uc011dkn.1_Missense_Mutation_p.S177F	NM_006994	NP_008925	O00478	BT3A3_HUMAN	butyrophilin, subfamily 3, member A3 isoform a	219	Extracellular (Potential).|Ig-like V-type 2.					integral to membrane					0						GGGGGTGTATCCTGCATCATC	0.552		NaN											0	0	0	0.01441	0	54	81									
BTN2A1	11120	broad.mit.edu	37	6	26459743	26459743	+	Silent	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr6:26459743C>T	uc003nib.1	+	3	329	c.117C>T	c.(115-117)ATC>ATT	p.I39I	BTN2A1_uc003nic.1_Silent_p.I39I|BTN2A1_uc003nid.1_5'UTR|BTN2A1_uc011dko.1_5'UTR	NM_007049	NP_008980	Q7KYR7	BT2A1_HUMAN	butyrophilin, subfamily 2, member A1 isoform 1	39	Extracellular (Potential).|Ig-like V-type.				lipid metabolic process	integral to plasma membrane				ovary(1)|skin(1)	2						CTGATCCCATCTTGGCCACGG	0.522		NaN											0	0	0	0.00308	0	8	41									
BTN1A1	696	broad.mit.edu	37	6	26501556	26501556	+	Silent	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr6:26501556C>T	uc003nif.3	+	1	62	c.42C>T	c.(40-42)CTC>CTT	p.L14L		NM_001732	NP_001723	Q13410	BT1A1_HUMAN	butyrophilin, subfamily 1, member A1 precursor	14						extracellular region|integral to plasma membrane	receptor activity			ovary(1)|skin(1)	2						GATGTCTGCTCACCCTCATTC	0.483		NaN											0	0	0	0.00278	0	21	67									
HIST1H4I	8294	broad.mit.edu	37	6	27107327	27107327	+	Silent	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr6:27107327G>A	uc003niy.1	+	1	240	c.240G>A	c.(238-240)AAG>AAA	p.K80K	HIST1H2BK_uc003nix.1_Intron	NM_003495	NP_003486	P62805	H4_HUMAN	histone cluster 1, H4i	80					CenH3-containing nucleosome assembly at centromere|negative regulation of megakaryocyte differentiation|phosphatidylinositol-mediated signaling|telomere maintenance	nucleoplasm|nucleosome	DNA binding|protein binding			lung(1)	1						CCAAGCGCAAGACGGTCACCG	0.597		NaN	T	BCL6	NHL								0	0	0	0.004482	0	7	44									
HIST1H2AL	8332	broad.mit.edu	37	6	27833492	27833492	+	Silent	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr6:27833492G>A	uc003njw.2	+	1	386	c.360G>A	c.(358-360)AAG>AAA	p.K120K		NM_003511	NP_003502	P0C0S8	H2A1_HUMAN	histone cluster 1, H2al	120					nucleosome assembly	nucleosome|nucleus	DNA binding|enzyme binding				0						TGCCCAAGAAGACCGAGAGTC	0.522		NaN											0	0	0	0.014323	0	19	88									
ZNF165	7718	broad.mit.edu	37	6	28056944	28056944	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr6:28056944C>T	uc003nkg.2	+	5	2238	c.1154C>T	c.(1153-1155)TCA>TTA	p.S385L	ZNF165_uc003nkh.2_Missense_Mutation_p.S385L|ZNF165_uc003nki.3_Missense_Mutation_p.S385L|ZSCAN12P1_uc003nkj.3_5'Flank	NM_003447	NP_003438	P49910	ZN165_HUMAN	zinc finger protein 165	385	C2H2-type 3.				viral reproduction	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0						GCAGAGAGCTCAGATCTTACT	0.453		NaN											0	0	0	0.008871	0	20	64									
TRIM10	10107	broad.mit.edu	37	6	30126201	30126201	+	Missense_Mutation	SNP	T	T	C			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr6:30126201T>C	uc003npo.3	-	3	807	c.731A>G	c.(730-732)GAG>GGG	p.E244G	TRIM10_uc003npn.2_Missense_Mutation_p.E244G	NM_006778	NP_006769	Q9UDY6	TRI10_HUMAN	tripartite motif-containing 10 isoform 1	244						cytoplasm	zinc ion binding				0						TGCTGGCCTCTCATTCTTCTC	0.537		NaN											0	0	0	0.006999	0	41	219									
MDC1	9656	broad.mit.edu	37	6	30681764	30681764	+	Silent	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr6:30681764C>T	uc003nrg.3	-	3	773	c.333G>A	c.(331-333)GTG>GTA	p.V111V	MDC1_uc003nrf.3_5'Flank|MDC1_uc011dmp.1_Intron|MDC1_uc003nrh.1_Intron|MDC1_uc003nri.2_Silent_p.V111V	NM_014641	NP_055456	Q14676	MDC1_HUMAN	mediator of DNA-damage checkpoint 1	111	Interaction with the MRN complex.|Interaction with CHEK2.				cell cycle|double-strand break repair via homologous recombination|intra-S DNA damage checkpoint	focal adhesion|nucleoplasm	FHA domain binding|protein C-terminus binding			breast(2)|ovary(1)|kidney(1)	4						GACGGTGACTCACCCCAGGGC	0.542		NaN						Other_conserved_DNA_damage_response_genes					0	0	0	0.00499	0	18	75									
CSNK2B	1460	broad.mit.edu	37	6	31635725	31635725	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr6:31635725C>G	uc003nvr.1	+	3	493	c.153C>G	c.(151-153)GAC>GAG	p.D51E	BAT4_uc003nvn.2_5'Flank|BAT4_uc003nvo.3_5'Flank|BAT4_uc003nvp.3_5'Flank|BAT4_uc003nvq.2_5'Flank|CSNK2B_uc010jta.1_Missense_Mutation_p.D51E|CSNK2B_uc003nvs.1_Missense_Mutation_p.D51E	NM_001320	NP_001311	P67870	CSK2B_HUMAN	casein kinase 2, beta polypeptide	51					adiponectin-mediated signaling pathway|axon guidance|cellular protein complex assembly|negative regulation of cell proliferation|regulation of DNA binding|Wnt receptor signaling pathway	cytosol|nucleus|protein kinase CK2 complex	identical protein binding|protein domain specific binding|protein kinase regulator activity|receptor binding|transcription factor binding				0						AAGCTCTAGACATGATCTTGG	0.463		NaN											0	0	0	0.008871	0	21	63									
EGFL8	80864	broad.mit.edu	37	6	32134565	32134565	+	Silent	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr6:32134565C>T	uc003oab.1	+	4	370	c.312C>T	c.(310-312)CAC>CAT	p.H104H	PPT2_uc003nzy.1_RNA|EGFL8_uc003oac.1_Silent_p.H104H	NM_030652	NP_085155	Q99944	EGFL8_HUMAN	NG3 protein precursor	104	EMI.					extracellular region|integral to membrane	calcium ion binding				0						AGAAGCGGCACCCGGGGGCGC	0.667		NaN											0	0	0	0.010729	0	10	31									
RPS18	6222	broad.mit.edu	37	6	33244172	33244172	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr6:33244172C>T	uc003odp.1	+	6	433	c.388C>T	c.(388-390)CGT>TGT	p.R130C	RPS18_uc010jum.1_RNA|RPS18_uc003odq.1_RNA|B3GALT4_uc003odr.2_5'Flank	NM_022551	NP_072045	P62269	RS18_HUMAN	ribosomal protein S18	130					endocrine pancreas development|ribosome biogenesis|translational elongation|translational termination|viral transcription	cytosolic small ribosomal subunit	rRNA binding|structural constituent of ribosome				0						CTGCAGCCTTCGTGTCCGAGG	0.512		NaN											0	0	0	0.009096	0	4	27									
ZBTB22	9278	broad.mit.edu	37	6	33283235	33283235	+	Silent	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr6:33283235G>A	uc003oeb.2	-	2	1611	c.1459C>T	c.(1459-1461)CTG>TTG	p.L487L	TAPBP_uc003odx.1_5'Flank|TAPBP_uc010jus.1_5'Flank|TAPBP_uc003ody.2_5'Flank|TAPBP_uc003odz.2_5'Flank|TAPBP_uc010jut.1_5'Flank|TAPBP_uc011drc.1_5'Flank|ZBTB22_uc010juu.2_Silent_p.L487L	NM_005453	NP_005444	O15209	ZBT22_HUMAN	zinc finger and BTB domain containing 22	487	C2H2-type 1; atypical.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						CAATGGCACAGAAAGATCTTA	0.627		NaN											0	0	0	0.004289	0	38	141									
ZBTB22	9278	broad.mit.edu	37	6	33284430	33284430	+	Silent	SNP	G	G	C			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr6:33284430G>C	uc003oeb.2	-	2	416	c.264C>G	c.(262-264)CTC>CTG	p.L88L	TAPBP_uc003odx.1_5'Flank|TAPBP_uc010jus.1_5'Flank|TAPBP_uc003ody.2_5'Flank|TAPBP_uc003odz.2_5'Flank|TAPBP_uc010jut.1_5'Flank|TAPBP_uc011drc.1_5'Flank|ZBTB22_uc010juu.2_Silent_p.L88L	NM_005453	NP_005444	O15209	ZBT22_HUMAN	zinc finger and BTB domain containing 22	88	BTB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						TCATGCCTTTGAGTAGGACCT	0.602		NaN											0	0	0	0.004656	0	24	155									
DAXX	1616	broad.mit.edu	37	6	33287200	33287200	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr6:33287200G>A	uc003oec.2	-	6	2101	c.1897C>T	c.(1897-1899)CGG>TGG	p.R633W	ZBTB22_uc003oeb.2_5'Flank|ZBTB22_uc010juu.2_5'Flank|DAXX_uc011drd.1_Missense_Mutation_p.R558W|DAXX_uc011dre.1_Missense_Mutation_p.R645W|DAXX_uc003oed.2_Missense_Mutation_p.R633W	NM_001350	NP_001341	Q9UER7	DAXX_HUMAN	death-domain associated protein isoform a	633	Nuclear localization signal (Potential).|Interaction with SPOP.				activation of JUN kinase activity|androgen receptor signaling pathway|apoptosis|induction of apoptosis via death domain receptors|interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|regulation of protein ubiquitination|transcription, DNA-dependent	chromosome, centromeric region|cytosol|nucleolus|PML body	androgen receptor binding|heat shock protein binding|p53 binding|protein homodimerization activity|protein N-terminus binding|receptor signaling protein activity|transcription factor binding|ubiquitin protein ligase binding			pancreas(18)|ovary(2)|skin(2)|prostate(1)	23						TTCTCCTTCCGAGATTTTTTG	0.507		NaN	Mis|F|N		Pancreatic neuroendocrine tumors								0	0	0	0.01441	0	47	225									
CUTA	51596	broad.mit.edu	37	6	33385311	33385311	+	Silent	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr6:33385311G>A	uc003oej.1	-	2	492	c.204C>T	c.(202-204)GTC>GTT	p.V68V	CUTA_uc003oek.1_Silent_p.V45V|CUTA_uc003oel.1_Silent_p.V45V|CUTA_uc003oem.1_Silent_p.V45V|CUTA_uc003oen.1_Silent_p.V87V|SYNGAP1_uc003oeo.1_5'Flank|SYNGAP1_uc011dri.1_5'Flank|SYNGAP1_uc010juy.2_5'Flank	NM_001014840	NP_001014840	O60888	CUTA_HUMAN	cutA divalent cation tolerance homolog isoform	68					protein localization|response to metal ion	membrane	enzyme binding				0						AGGCTGCAGAGACCGAGCCCG	0.612		NaN											0	0	0	0.004289	0	34	86									
SCUBE3	222663	broad.mit.edu	37	6	35213121	35213121	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr6:35213121C>T	uc003okf.1	+	19	2524	c.2518C>T	c.(2518-2520)CGC>TGC	p.R840C	SCUBE3_uc003okg.1_Missense_Mutation_p.R839C|SCUBE3_uc003okh.1_Missense_Mutation_p.R727C	NM_152753	NP_689966	Q8IX30	SCUB3_HUMAN	signal peptide, CUB domain, EGF-like 3	840	CUB.				protein heterooligomerization|protein homooligomerization	cell surface|extracellular region	calcium ion binding|protein binding			skin(1)	1						CCCACCCAAGCGCAAGATCCT	0.557		NaN											0	0	0	0.008871	0	20	83									
LRFN2	57497	broad.mit.edu	37	6	40400146	40400146	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr6:40400146G>A	uc003oph.1	-	2	1172	c.707C>T	c.(706-708)TCC>TTC	p.S236F		NM_020737	NP_065788	Q9ULH4	LRFN2_HUMAN	leucine rich repeat and fibronectin type III	236	Extracellular (Potential).					cell junction|integral to membrane|postsynaptic membrane				ovary(2)|skin(1)	3	Ovarian(28;0.0418)|Colorectal(47;0.196)					AAAACTAAAGGACAAGGGTGG	0.597		NaN											0	0	0	0.004007	0	9	35									
NCR2	9436	broad.mit.edu	37	6	41303625	41303625	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr6:41303625G>A	uc003oqh.2	+	1	98	c.11G>A	c.(10-12)CGA>CAA	p.R4Q	NCR2_uc003oqi.2_Missense_Mutation_p.R4Q|NCR2_uc003oqj.2_Missense_Mutation_p.R4Q	NM_004828	NP_004819	O95944	NCTR2_HUMAN	natural cytotoxicity triggering receptor 2	4					cellular defense response	integral to plasma membrane	transmembrane receptor activity			ovary(1)	1	Ovarian(28;0.0327)|Colorectal(47;0.196)					ATGGCCTGGCGAGCCCTACAC	0.622		NaN											0	0	0	0.004672	0	3	4									
NFKBIE	4794	broad.mit.edu	37	6	44227792	44227792	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr6:44227792G>T	uc003oxe.1	-	5	1450	c.1425C>A	c.(1423-1425)GAC>GAA	p.D475E	SLC35B2_uc003oxd.2_5'Flank|SLC35B2_uc011dvt.1_5'Flank|SLC35B2_uc011dvu.1_5'Flank	NM_004556	NP_004547	O00221	IKBE_HUMAN	nuclear factor of kappa light polypeptide gene	475					cytoplasmic sequestering of transcription factor		protein binding			breast(2)	2	all_cancers(18;2e-05)|all_lung(25;0.00747)|Hepatocellular(11;0.00908)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)			CCTCAGTCAGGTCCTGGGGCG	0.517		NaN											1	0	3.07112e-06	0.010729	3.14246e-06	12	51									
TDRD6	221400	broad.mit.edu	37	6	46658620	46658620	+	Nonsense_Mutation	SNP	G	G	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr6:46658620G>T	uc003oyj.2	+	1	2755	c.2755G>T	c.(2755-2757)GAA>TAA	p.E919*	TDRD6_uc010jze.2_Nonsense_Mutation_p.E913*	NM_001010870	NP_001010870	O60522	TDRD6_HUMAN	tudor domain containing 6	919					cell differentiation|multicellular organismal development|spermatogenesis	chromatoid body	nucleic acid binding			breast(3)|ovary(2)|skin(1)	6			Lung(136;0.192)			AAAAAATCTAGAATTAAAATG	0.338		NaN											1	0	3.8784e-16	0.012319	4.06287e-16	20	155									
MEP1A	4224	broad.mit.edu	37	6	46794205	46794205	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr6:46794205G>A	uc010jzh.1	+	9	935	c.893G>A	c.(892-894)GGA>GAA	p.G298E	MEP1A_uc011dwg.1_Missense_Mutation_p.G20E|MEP1A_uc011dwh.1_Missense_Mutation_p.G326E|MEP1A_uc011dwi.1_Missense_Mutation_p.G198E	NM_005588	NP_005579	Q16819	MEP1A_HUMAN	meprin A alpha precursor	298	Extracellular (Potential).|MAM.				digestion|proteolysis	extracellular space|integral to plasma membrane|soluble fraction	metalloendopeptidase activity|zinc ion binding			pancreas(2)|ovary(1)	3			Lung(136;0.192)			GCTCAGGCTGGAGAAGTGGAT	0.488		NaN											0	0	0	0.01441	0	48	81									
PKHD1	5314	broad.mit.edu	37	6	51908451	51908451	+	Silent	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr6:51908451G>A	uc003pah.1	-	26	3069	c.2793C>T	c.(2791-2793)CCC>CCT	p.P931P	PKHD1_uc003pai.2_Silent_p.P931P	NM_138694	NP_619639	P08F94	PKHD1_HUMAN	fibrocystin isoform 1	931	IPT/TIG 4.|Extracellular (Potential).				cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			lung(15)|ovary(15)|large_intestine(5)|central_nervous_system(3)|skin(3)|breast(2)|upper_aerodigestive_tract(1)	44	Lung NSC(77;0.0605)					AATGGACACAGGGAGTTGACC	0.473		NaN											0	0	0	0.003755	0	37	34									
GJA10	84694	broad.mit.edu	37	6	90604653	90604653	+	Missense_Mutation	SNP	A	A	G			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr6:90604653A>G	uc011eaa.1	+	1	466	c.466A>G	c.(466-468)ACT>GCT	p.T156A		NM_032602	NP_115991	Q969M2	CXA10_HUMAN	gap junction protein, alpha 10	156	Cytoplasmic (Potential).				synaptic transmission	connexon complex|integral to membrane	gap junction channel activity				0		all_cancers(76;5.71e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00527)		BRCA - Breast invasive adenocarcinoma(108;0.0915)		TCTGCTGCGTACTTATGTCTT	0.438		NaN											0	0	0	0.01441	0	59	83									
EPHA7	2045	broad.mit.edu	37	6	94068097	94068097	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr6:94068097G>A	uc003poe.2	-	4	1106	c.865C>T	c.(865-867)CAA>TAA	p.Q289*	EPHA7_uc003pof.2_Nonsense_Mutation_p.Q289*|EPHA7_uc011eac.1_Nonsense_Mutation_p.Q289*	NM_004440	NP_004431	Q15375	EPHA7_HUMAN	ephrin receptor EphA7 precursor	289	Extracellular (Potential).|Cys-rich.					integral to plasma membrane	ATP binding|ephrin receptor activity			lung(8)|ovary(7)|upper_aerodigestive_tract(3)|central_nervous_system(3)|skin(3)|large_intestine(2)|stomach(1)|pancreas(1)	28		all_cancers(76;7.47e-10)|Acute lymphoblastic leukemia(125;1.88e-09)|all_hematologic(75;1.75e-07)|all_epithelial(107;3.6e-05)|Lung NSC(302;0.0368)|all_lung(197;0.0509)|Colorectal(196;0.142)		BRCA - Breast invasive adenocarcinoma(108;0.0847)		TGAAGATCTTGAGAGGAAGAC	0.413		NaN											0	0	0	0.013537	0	11	25									
FHL5	9457	broad.mit.edu	37	6	97051647	97051647	+	Missense_Mutation	SNP	A	A	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr6:97051647A>T	uc003pos.1	+	3	563	c.158A>T	c.(157-159)AAG>ATG	p.K53M	FHL5_uc003pot.1_Missense_Mutation_p.K53M	NM_020482	NP_065228	Q5TD97	FHL5_HUMAN	activator of cAMP-responsive element modulator	53	LIM zinc-binding 1.					nucleus	zinc ion binding			ovary(2)	2		all_cancers(76;1.57e-07)|Acute lymphoblastic leukemia(125;4.93e-10)|all_hematologic(75;3.55e-07)|all_epithelial(107;0.00266)|Colorectal(196;0.0341)|Lung NSC(302;0.204)		BRCA - Breast invasive adenocarcinoma(108;0.0948)		TCTGATTCTAAGGTAAGTCTC	0.358		NaN											0	0	0	0.00874	0	42	64									
SIM1	6492	broad.mit.edu	37	6	100841697	100841697	+	Silent	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr6:100841697G>A	uc003pqj.3	-	10	1443	c.1236C>T	c.(1234-1236)ACC>ACT	p.T412T	SIM1_uc010kcu.2_Silent_p.T412T	NM_005068	NP_005059	P81133	SIM1_HUMAN	single-minded homolog 1	412	Single-minded C-terminal.				cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			ovary(4)	4		all_cancers(76;9.88e-06)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(107;0.0248)|Colorectal(196;0.13)		BRCA - Breast invasive adenocarcinoma(108;0.0774)		AGGCCGTGTCGGTCAAGGGAC	0.572		NaN											0	0	0	0.014323	0	21	22									
TRAF3IP2	10758	broad.mit.edu	37	6	111913025	111913025	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr6:111913025C>T	uc011ebc.1	-	3	880	c.265G>A	c.(265-267)GAG>AAG	p.E89K	TRAF3IP2_uc003pvg.2_Missense_Mutation_p.E89K|TRAF3IP2_uc003pvf.2_Missense_Mutation_p.E89K|TRAF3IP2_uc010kdw.2_Missense_Mutation_p.E89K|TRAF3IP2_uc010kdx.2_Missense_Mutation_p.E89K	NM_147686	NP_679211	O43734	CIKS_HUMAN	TRAF3 interacting protein 2 isoform 2	98					intracellular signal transduction|positive regulation of I-kappaB kinase/NF-kappaB cascade	intracellular				ovary(2)|central_nervous_system(1)	3		all_cancers(87;7.87e-06)|Acute lymphoblastic leukemia(125;3.61e-09)|all_hematologic(75;2.63e-07)|all_epithelial(87;0.0024)|Colorectal(196;0.021)		OV - Ovarian serous cystadenocarcinoma(136;0.033)|all cancers(137;0.0412)|Epithelial(106;0.0732)		TCACTGTCCTCCAGAACTTGA	0.567		NaN											0	0	0	0.004289	0	37	55									
C6orf174	387104	broad.mit.edu	37	6	127797109	127797109	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr6:127797109C>T	uc003qbd.2	-	6	2927	c.2062G>A	c.(2062-2064)GAC>AAC	p.D688N	C6orf174_uc003qbc.2_5'Flank	NM_001012279	NP_001012279	Q5TF21	CF174_HUMAN	hypothetical protein LOC387104 precursor	688	Potential.					integral to membrane				breast(3)|ovary(2)|skin(1)	6				GBM - Glioblastoma multiforme(226;0.026)|all cancers(137;0.161)		CGCGCGCTGTCGTGGCCGCCG	0.652		NaN											0	0	0	0.003954	0	22	37									
MYB	4602	broad.mit.edu	37	6	135521495	135521495	+	Missense_Mutation	SNP	G	G	A	rs113182184	byFrequency	TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr6:135521495G>A	uc003qfc.2	+	12	1728	c.1529G>A	c.(1528-1530)GGA>GAA	p.G510E	MYB_uc003qfh.2_Missense_Mutation_p.G631E|MYB_uc003qfi.2_Missense_Mutation_p.G615E|MYB_uc010kgi.2_Missense_Mutation_p.G510E|MYB_uc003qfq.2_Missense_Mutation_p.G628E|MYB_uc010kgj.2_Missense_Mutation_p.G475E|MYB_uc003qfo.2_Missense_Mutation_p.G425E|MYB_uc003qfu.2_Missense_Mutation_p.G507E|MYB_uc003qfl.2_RNA|MYB_uc003qfv.2_RNA|MYB_uc003qfz.2_RNA|MYB_uc003qfx.2_RNA|MYB_uc003qga.2_RNA|MYB_uc003qgb.2_RNA|MYB_uc010kgk.2_RNA|MYB_uc003qfd.2_RNA|MYB_uc003qfe.2_RNA|MYB_uc003qfg.2_RNA|MYB_uc003qff.2_RNA|MYB_uc003qfj.2_RNA|MYB_uc003qfm.2_RNA|MYB_uc003qfp.2_RNA|MYB_uc003qfn.2_RNA|MYB_uc003qfk.2_RNA|MYB_uc003qfr.2_RNA|MYB_uc003qfs.2_Missense_Mutation_p.G136E|MYB_uc003qft.2_RNA|MYB_uc003qfw.2_Missense_Mutation_p.G322E|MYB_uc003qfy.2_RNA|MYB_uc003qgc.2_RNA|MYB_uc003qfb.1_Missense_Mutation_p.G510E	NM_005375	NP_005366	P10242	MYB_HUMAN	v-myb myeloblastosis viral oncogene homolog	510					blood coagulation|chromatin remodeling|negative regulation of transcription from RNA polymerase II promoter|positive regulation of histone H3-K4 methylation|positive regulation of histone H3-K9 methylation|positive regulation of T-helper cell differentiation|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear matrix	DNA binding|protein binding			lung(1)	1	all_epithelial(2;0.109)|Breast(56;0.158)|Colorectal(23;0.221)	Lung NSC(302;3.08e-05)|Ovarian(999;0.208)		OV - Ovarian serous cystadenocarcinoma(155;0.0079)|GBM - Glioblastoma multiforme(68;0.0117)		GATGAATCTGGAATTGTTGCT	0.428		NaN	T	NFIB	adenoid cystic carcinoma								0	0	0	0.00874	0	45	50									
PDE7B	27115	broad.mit.edu	37	6	136502427	136502427	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr6:136502427G>C	uc003qgp.2	+	11	1314	c.1011G>C	c.(1009-1011)TGG>TGC	p.W337C	uc003qgq.1_Intron|PDE7B_uc003qgr.2_Missense_Mutation_p.W389C	NM_018945	NP_061818	Q9NP56	PDE7B_HUMAN	phosphodiesterase 7B	337	Catalytic (By similarity).				signal transduction|synaptic transmission	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding			ovary(1)	1	Colorectal(23;0.24)			OV - Ovarian serous cystadenocarcinoma(155;0.0136)|GBM - Glioblastoma multiforme(68;0.0147)	Dyphylline(DB00651)|Ketotifen(DB00920)	GCAAGCAGTGGAGTGAAAGGG	0.438		NaN											0	0	0	0.004656	0	25	119									
GPR126	57211	broad.mit.edu	37	6	142691518	142691518	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr6:142691518G>C	uc010khc.2	+	4	1068	c.657G>C	c.(655-657)AAG>AAC	p.K219N	GPR126_uc010khd.2_Missense_Mutation_p.K219N|GPR126_uc010khe.2_Missense_Mutation_p.K219N|GPR126_uc010khf.2_Missense_Mutation_p.K219N|GPR126_uc003qix.2_Missense_Mutation_p.K219N	NM_020455	NP_065188	Q86SQ4	GP126_HUMAN	G protein-coupled receptor 126 alpha 1	219	Pentaxin.|Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(1)	1	Breast(32;0.176)			OV - Ovarian serous cystadenocarcinoma(155;9.33e-06)|GBM - Glioblastoma multiforme(68;0.00121)		GAAAGGCCAAGAGTGGCTACT	0.388		NaN											0	0	0	0.013537	0	11	31									
PPIL4	85313	broad.mit.edu	37	6	149856762	149856762	+	Missense_Mutation	SNP	T	T	C			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr6:149856762T>C	uc003qmo.1	-	5	464	c.434A>G	c.(433-435)GAC>GGC	p.D145G	PPIL4_uc010kic.2_RNA|PPIL4_uc003qmp.1_Missense_Mutation_p.D145G	NM_139126	NP_624311	Q8WUA2	PPIL4_HUMAN	peptidylprolyl isomerase-like 4	145	PPIase cyclophilin-type.				protein folding	nucleus	nucleotide binding|peptidyl-prolyl cis-trans isomerase activity|RNA binding				0		Ovarian(120;0.0164)		OV - Ovarian serous cystadenocarcinoma(155;1.11e-11)|GBM - Glioblastoma multiforme(68;0.0885)		AAAGTCCTTGTCAACAAAGGT	0.353		NaN											0	0	0	0.004878	0	38	77									
ARID1B	57492	broad.mit.edu	37	6	157502230	157502230	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr6:157502230C>T	uc003qqn.2	+	12	3361	c.3209C>T	c.(3208-3210)TCA>TTA	p.S1070L	ARID1B_uc003qqo.2_Missense_Mutation_p.S1030L|ARID1B_uc003qqp.2_Missense_Mutation_p.S1017L|ARID1B_uc010kjl.2_Missense_Mutation_p.S215L	NM_017519	NP_059989	Q8NFD5	ARI1B_HUMAN	AT rich interactive domain 1B (SWI1-like)	1075	ARID.				chromatin-mediated maintenance of transcription|nervous system development|transcription, DNA-dependent	SWI/SNF complex	DNA binding|protein binding|transcription coactivator activity			ovary(1)|breast(1)	2		Breast(66;0.000162)|Ovarian(120;0.0265)		OV - Ovarian serous cystadenocarcinoma(65;3.19e-17)|BRCA - Breast invasive adenocarcinoma(81;1.01e-05)		TCTCCTGTCTCAAGTCTGCCT	0.562		NaN											0	0	0	0.010504	0	19	21									
SYNJ2	8871	broad.mit.edu	37	6	158499228	158499228	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr6:158499228G>C	uc003qqx.1	+	18	2557	c.2482G>C	c.(2482-2484)GAT>CAT	p.D828H	SYNJ2_uc003qqw.1_Missense_Mutation_p.D828H|SYNJ2_uc003qqy.1_Missense_Mutation_p.D541H|SYNJ2_uc003qqz.1_Missense_Mutation_p.D445H|SYNJ2_uc003qra.1_Missense_Mutation_p.D171H	NM_003898	NP_003889	O15056	SYNJ2_HUMAN	synaptojanin 2	828	Catalytic (By similarity).						nucleotide binding|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|RNA binding			skin(1)	1				OV - Ovarian serous cystadenocarcinoma(65;4.42e-18)|BRCA - Breast invasive adenocarcinoma(81;4.23e-05)		CAGTGATCTAGATGTTGACAC	0.493		NaN											0	0	0	0.010504	0	21	103									
THBS2	7058	broad.mit.edu	37	6	169648940	169648940	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr6:169648940C>T	uc003qwt.2	-	4	429	c.181G>A	c.(181-183)GAC>AAC	p.D61N		NM_003247	NP_003238	P35442	TSP2_HUMAN	thrombospondin 2 precursor	61	TSP N-terminal.|Heparin-binding (Potential).				cell adhesion	extracellular region	calcium ion binding|heparin binding|protein binding|structural molecule activity			ovary(5)	5		Breast(66;1.78e-05)|Ovarian(120;0.0728)|Esophageal squamous(34;0.247)		OV - Ovarian serous cystadenocarcinoma(33;1.85e-21)|BRCA - Breast invasive adenocarcinoma(81;1.43e-06)|GBM - Glioblastoma multiforme(31;0.000379)		GGGATGTAGTCAAAGCGCACG	0.602		NaN											0	0	0	0.008871	0	20	26									
LFNG	3955	broad.mit.edu	37	7	2565141	2565141	+	Silent	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr7:2565141C>T	uc003smf.2	+	4	692	c.675C>T	c.(673-675)GTC>GTT	p.V225V	LFNG_uc003smg.2_Silent_p.V225V	NM_001040167	NP_001035257	Q8NES3	LFNG_HUMAN	lunatic fringe isoform a	225	Lumenal (Potential).				organ morphogenesis	extracellular region|integral to Golgi membrane	O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity				0		Ovarian(82;0.0112)		OV - Ovarian serous cystadenocarcinoma(56;2.54e-14)		ACGTCTACGTCGGCAAGCCCA	0.677		NaN											0	0	0	0.004482	0	8	14									
PMS2	5395	broad.mit.edu	37	7	6027006	6027006	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr7:6027006C>T	uc003spl.2	-	11	1477	c.1390G>A	c.(1390-1392)GAC>AAC	p.D464N	PMS2_uc003spj.2_Missense_Mutation_p.D358N|PMS2_uc003spk.2_Missense_Mutation_p.D329N|PMS2_uc011jwl.1_Missense_Mutation_p.D329N|PMS2_uc010ktg.2_Missense_Mutation_p.D153N|PMS2_uc010kte.2_Intron|PMS2_uc010ktf.1_Missense_Mutation_p.D464N	NM_000535	NP_000526	P54278	PMS2_HUMAN	PMS2 postmeiotic segregation increased 2 isoform	464					mismatch repair|reciprocal meiotic recombination|somatic hypermutation of immunoglobulin genes	MutLalpha complex	ATP binding|ATPase activity|endonuclease activity|protein binding|single base insertion or deletion binding			lung(1)|central_nervous_system(1)	2		Ovarian(82;0.0694)		UCEC - Uterine corpus endometrioid carcinoma (126;0.101)|OV - Ovarian serous cystadenocarcinoma(56;4.39e-15)		ACGCCTTTGTCAGAGATGGCA	0.562		NaN	Mis|N|F			colorectal|endometrial|ovarian|medulloblastoma|glioma		Direct_reversal_of_damage|MMR	Lynch_syndrome|Turcot_syndrome|Constitutional_Mismatch_Repair_Deficiency_Syndrome				0	0	0	0.00874	0	45	111									
BZW2	28969	broad.mit.edu	37	7	16714045	16714045	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr7:16714045G>C	uc003stl.2	+	3	245	c.67G>C	c.(67-69)GAG>CAG	p.E23Q	BZW2_uc011jxx.1_5'UTR|BZW2_uc003stm.2_5'UTR|BZW2_uc003stj.2_Missense_Mutation_p.E23Q|BZW2_uc003stk.2_5'UTR|BZW2_uc003stn.1_Missense_Mutation_p.E23Q|BZW2_uc003sto.1_5'UTR|BZW2_uc003stp.2_5'UTR|BZW2_uc010kua.2_Missense_Mutation_p.E23Q	NM_001159767	NP_001153239	Q9Y6E2	BZW2_HUMAN	basic leucine zipper and W2 domains 2	23					cell differentiation|nervous system development|RNA metabolic process		protein binding			ovary(2)	2	Lung NSC(10;0.0367)|all_lung(11;0.0837)			UCEC - Uterine corpus endometrioid carcinoma (126;0.199)		AGATGAAAAAGAGAAATTCGA	0.328		NaN											0	0	0	0.007413	0	18	122									
C7orf46	340277	broad.mit.edu	37	7	23731113	23731113	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr7:23731113G>A	uc003swo.3	+	4	624	c.535G>A	c.(535-537)GAA>AAA	p.E179K	C7orf46_uc003swq.3_Missense_Mutation_p.E179K|C7orf46_uc003swr.3_Missense_Mutation_p.E121K|C7orf46_uc003swp.3_RNA|C7orf46_uc010kup.2_RNA	NM_199136	NP_954587	A4D161	CG046_HUMAN	hypothetical protein LOC340277 isoform 1	179											0						ATTGGCTCAGGAAAAACCAGT	0.493		NaN											0	0	0	0.01441	0	57	137									
TAX1BP1	8887	broad.mit.edu	37	7	27797748	27797748	+	Silent	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr7:27797748C>T	uc003szl.2	+	3	419	c.261C>T	c.(259-261)TTC>TTT	p.F87F	TAX1BP1_uc011jzo.1_Silent_p.F87F|TAX1BP1_uc003szk.2_Silent_p.F87F|TAX1BP1_uc011jzp.1_5'UTR	NM_006024	NP_006015	Q86VP1	TAXB1_HUMAN	Tax1 (human T-cell leukemia virus type I)	87					anti-apoptosis|apoptosis|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production	cytosol	identical protein binding|kinase binding|zinc ion binding			breast(1)	1			GBM - Glioblastoma multiforme(3;0.0823)			TACTAGCATTCCAAGGTAAGG	0.348		NaN											0	0	0	0.008871	0	20	110									
CHN2	1124	broad.mit.edu	37	7	29234571	29234571	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr7:29234571G>A	uc003szz.2	+	1	451	c.14G>A	c.(13-15)AGC>AAC	p.S5N	CHN2_uc011jzs.1_Intron|CHN2_uc010kva.2_Missense_Mutation_p.S5N|CHN2_uc010kvb.2_RNA|CHN2_uc010kvc.2_5'UTR|CHN2_uc011jzt.1_Missense_Mutation_p.S5N|CHN2_uc010kvd.2_Missense_Mutation_p.S5N|CHN2_uc011jzu.1_5'Flank|CPVL_uc003szx.2_Intron	NM_004067	NP_004058	P52757	CHIO_HUMAN	beta chimerin isoform 2	5				MAASSN -> MRLL (in Ref. 1; AAA16836/ AAA19191).	regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|membrane	GTPase activator activity|metal ion binding|SH3/SH2 adaptor activity			ovary(2)	2						gcagcgTCCAGCAACTCCAGC	0.383		NaN											0	0	0	0.006214	0	7	18									
BMPER	168667	broad.mit.edu	37	7	34125385	34125385	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr7:34125385G>C	uc011kap.1	+	13	1540	c.1426G>C	c.(1426-1428)GAT>CAT	p.D476H		NM_133468	NP_597725	Q8N8U9	BMPER_HUMAN	BMP-binding endothelial regulator precursor	476	VWFD.				blood vessel endothelial cell proliferation involved in sprouting angiogenesis|endothelial cell activation|negative regulation of BMP signaling pathway|positive regulation of ERK1 and ERK2 cascade|regulation of endothelial cell migration|regulation of pathway-restricted SMAD protein phosphorylation	extracellular space				ovary(2)|central_nervous_system(1)	3						AATATCTTGGGATGGAGACAG	0.423		NaN											0	0	0	0.00308	0	8	47									
TARP	445347	broad.mit.edu	37	7	38305062	38305062	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr7:38305062G>C	uc003tge.1	-	5	1022	c.645C>G	c.(643-645)AGC>AGG	p.S215R	uc003tfz.1_Intron|TARP_uc003tgb.2_Missense_Mutation_p.S11R|TARP_uc003tgc.1_Missense_Mutation_p.S11R|TARP_uc003tgd.1_Missense_Mutation_p.S11R|TARP_uc010kxi.1_RNA|TARP_uc003tgf.1_RNA|TARP_uc003tgj.1_RNA|TARP_uc003tgh.1_RNA|TARP_uc003tgi.1_RNA|TARP_uc003tgg.1_RNA			A2JGV3	A2JGV3_HUMAN	Homo sapiens TCRgamma alternate reading frame protein (TCRg) mRNA, complete cds.	Error:Variant_position_missing_in_A2JGV3_after_alignment											0						CCGTTAACCAGCTAAATTTCA	0.393		NaN											0	0	0	0.01441	0	54	266									
NPC1L1	29881	broad.mit.edu	37	7	44579102	44579102	+	Silent	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr7:44579102G>A	uc003tlb.2	-	2	950	c.894C>T	c.(892-894)GTC>GTT	p.V298V	NPC1L1_uc003tlc.2_Silent_p.V298V|NPC1L1_uc011kbw.1_Silent_p.V298V|NPC1L1_uc003tld.2_Silent_p.V298V	NM_013389	NP_037521	Q9UHC9	NPCL1_HUMAN	Niemann-Pick C1-like protein 1 isoform 1	298	Helical; Name=1; (Potential).				cholesterol biosynthetic process|intestinal cholesterol absorption|lipoprotein metabolic process	apical plasma membrane|cytoplasmic vesicle membrane|integral to membrane	hedgehog receptor activity|protein binding			ovary(3)|central_nervous_system(1)|skin(1)	5					Ezetimibe(DB00973)	GCAGGATGGTGACCACAGCGA	0.612		NaN											0	0	0	0.007413	0	20	87									
TNS3	64759	broad.mit.edu	37	7	47467943	47467943	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr7:47467943G>A	uc003tnv.2	-	9	723	c.356C>T	c.(355-357)TCA>TTA	p.S119L	TNS3_uc003tnw.2_Missense_Mutation_p.S119L|TNS3_uc010kyo.1_Missense_Mutation_p.S119L	NM_022748	NP_073585	Q68CZ2	TENS3_HUMAN	tensin 3	119	Phosphatase tensin-type.					focal adhesion	protein binding			ovary(4)	4						CATGTAGGATGATATGACCAC	0.493		NaN											0	0	0	0.00632	0	25	93									
SUN3	256979	broad.mit.edu	37	7	48046822	48046822	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr7:48046822C>T	uc003tof.2	-	6	529	c.432G>A	c.(430-432)ATG>ATA	p.M144I	SUN3_uc010kyq.2_Missense_Mutation_p.M44I|SUN3_uc003tog.2_Missense_Mutation_p.M144I|SUN3_uc011kcf.1_Missense_Mutation_p.M132I	NM_152782	NP_689995	Q8TAQ9	SUN3_HUMAN	Sad1 and UNC84 domain containing 1	144	Potential.					integral to membrane				central_nervous_system(1)	1						GATTATTGTCCATACCATCCT	0.483		NaN											0	0	0	0.008871	0	21	70									
ZNF713	349075	broad.mit.edu	37	7	56007179	56007179	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr7:56007179C>T	uc003trc.1	+	4	811	c.773C>T	c.(772-774)TCA>TTA	p.S258L	ZNF713_uc003tra.1_Missense_Mutation_p.S271L|MRPS17_uc003trb.2_Intron	NM_182633	NP_872439	Q8N859	ZN713_HUMAN	zinc finger protein 713	258					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2	Breast(14;0.214)		Lung(13;0.00024)|LUSC - Lung squamous cell carcinoma(13;0.00099)			AGCCACACCTCATCTCTTAGC	0.423		NaN											0	0	0	0.003954	0	24	65									
CLDN4	1364	broad.mit.edu	37	7	73246019	73246019	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr7:73246019C>T	uc003tzi.3	+	1	827	c.488C>T	c.(487-489)TCG>TTG	p.S163L	RFC2_uc011kfa.1_Intron|CLDN4_uc003tzh.1_RNA	NM_001305	NP_001296	O14493	CLD4_HUMAN	claudin 4	163	Helical; (Potential).				calcium-independent cell-cell adhesion	integral to plasma membrane|tight junction	identical protein binding|structural molecule activity|transmembrane receptor activity				0		Lung NSC(55;0.159)				ATGGGTGCCTCGCTCTACGTC	0.637		NaN											0	0	0	0.006214	0	7	28									
TMEM130	222865	broad.mit.edu	37	7	98460916	98460916	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr7:98460916C>T	uc003upo.2	-	2	382	c.193G>A	c.(193-195)GCT>ACT	p.A65T	TMEM130_uc011kiq.1_Missense_Mutation_p.A46T|TMEM130_uc011kir.1_Missense_Mutation_p.A65T|TMEM130_uc003upn.2_Intron	NM_001134450	NP_001127922	Q8N3G9	TM130_HUMAN	transmembrane protein 130 isoform a	65	Extracellular (Potential).					Golgi membrane|integral to membrane				ovary(1)|central_nervous_system(1)	2	all_cancers(62;4.05e-09)|all_epithelial(64;2.62e-09)|Lung NSC(181;0.01)|all_lung(186;0.0115)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)			TGGGCGTCAGCGGGCAGGGCC	0.642		NaN											0	0	0	0.00308	0	6	11									
SLC26A4	5172	broad.mit.edu	37	7	107342406	107342406	+	Silent	SNP	C	C	G			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr7:107342406C>G	uc003vep.2	+	17	2162	c.1938C>G	c.(1936-1938)GTC>GTG	p.V646V	SLC26A4_uc011kmb.1_Silent_p.V233V|SLC26A4_uc011kmc.1_Silent_p.V207V|SLC26A4_uc011kmd.1_Silent_p.V215V	NM_000441	NP_000432	O43511	S26A4_HUMAN	pendrin	646	STAS.|Cytoplasmic (Potential).				regulation of pH|regulation of protein localization|sensory perception of sound	apical plasma membrane|integral to membrane	chloride transmembrane transporter activity|inorganic anion exchanger activity|iodide transmembrane transporter activity|secondary active sulfate transmembrane transporter activity			ovary(3)|central_nervous_system(2)|skin(2)	7						AGCTTCCAGTCAAAGTGAACG	0.453		NaN							Pendred_syndrome				0	0	0	0.001855	0	14	76									
LRRN3	54674	broad.mit.edu	37	7	110764893	110764893	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr7:110764893G>C	uc003vft.3	+	4	3111	c.2065G>C	c.(2065-2067)GAA>CAA	p.E689Q	IMMP2L_uc003vfq.1_Intron|IMMP2L_uc010ljr.1_Intron|IMMP2L_uc003vfr.2_Intron|LRRN3_uc003vfu.3_Missense_Mutation_p.E689Q|LRRN3_uc003vfs.3_Missense_Mutation_p.E689Q	NM_001099660	NP_001093130	Q9H3W5	LRRN3_HUMAN	leucine rich repeat neuronal 3 precursor	689	Cytoplasmic (Potential).					integral to membrane				skin(3)|ovary(2)|pancreas(2)|central_nervous_system(1)	8				UCEC - Uterine corpus endometrioid carcinoma (4;0.245)|LUSC - Lung squamous cell carcinoma(290;0.0715)|Lung(3;0.0864)|STAD - Stomach adenocarcinoma(3;0.125)		AGCAGGAAAAGAAAAAAGTAC	0.368		NaN											0	0	0	0.010729	0	11	84									
DOCK4	9732	broad.mit.edu	37	7	111634279	111634279	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr7:111634279C>G	uc003vfx.2	-	5	495	c.226G>C	c.(226-228)GAA>CAA	p.E76Q	DOCK4_uc003vfy.2_Missense_Mutation_p.E76Q|DOCK4_uc003vga.1_5'UTR|DOCK4_uc010ljt.1_Missense_Mutation_p.E76Q|DOCK4_uc003vgb.1_5'UTR	NM_014705	NP_055520	Q8N1I0	DOCK4_HUMAN	dedicator of cytokinesis 4	76					cell chemotaxis	cytosol|endomembrane system|membrane|stereocilium	GTP binding|guanyl-nucleotide exchange factor activity|PDZ domain binding|Rac GTPase activator activity|Rac GTPase binding|receptor tyrosine kinase binding|SH3 domain binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)	4		Acute lymphoblastic leukemia(1;0.0441)				ATAACCATTTCAAATTGTCTG	0.308		NaN											0	0	0	0.014323	0	23	89									
C7orf60	154743	broad.mit.edu	37	7	112579712	112579712	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr7:112579712C>T	uc003vgo.1	-	1	221	c.94G>A	c.(94-96)GAG>AAG	p.E32K	C7orf60_uc011kms.1_Missense_Mutation_p.E32K	NM_152556	NP_689769	Q1RMZ1	CG060_HUMAN	hypothetical protein LOC154743	32										ovary(2)|skin(1)	3						TTCTCCTGCTCCAGTTTCCGC	0.647		NaN											0	0	0	0.001984	0	7	28									
CTTNBP2	83992	broad.mit.edu	37	7	117400556	117400556	+	Silent	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr7:117400556C>T	uc003vjf.2	-	10	3197	c.3105G>A	c.(3103-3105)GTG>GTA	p.V1035V		NM_033427	NP_219499	Q8WZ74	CTTB2_HUMAN	cortactin binding protein 2	1035										ovary(4)|central_nervous_system(1)	5	Lung NSC(10;0.0018)|all_lung(10;0.002)			LUSC - Lung squamous cell carcinoma(290;0.133)		TATTGCAAGTCACGTCTTCCA	0.453		NaN											0	0	0	0.008361	0	29	180									
ING3	54556	broad.mit.edu	37	7	120614801	120614801	+	Missense_Mutation	SNP	A	A	C			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr7:120614801A>C	uc003vjn.2	+	12	1294	c.1160A>C	c.(1159-1161)CAT>CCT	p.H387P	ING3_uc003vjo.2_Missense_Mutation_p.H161P|ING3_uc003vjp.2_3'UTR|ING3_uc011kns.1_Missense_Mutation_p.H372P	NM_019071	NP_061944	Q9NXR8	ING3_HUMAN	inhibitor of growth family, member 3 isoform 1	387	PHD-type.				histone H2A acetylation|histone H4 acetylation|positive regulation of apoptosis|regulation of growth|regulation of transcription, DNA-dependent|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|Piccolo NuA4 histone acetyltransferase complex	zinc ion binding			ovary(1)	1	all_neural(327;0.117)					GAATGGTTCCATTATGGCTGC	0.413		NaN											0	0	0	0.00308	0	6	53									
PTPRZ1	5803	broad.mit.edu	37	7	121701184	121701184	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr7:121701184G>T	uc003vjy.2	+	30	7253	c.6858G>T	c.(6856-6858)AGG>AGT	p.R2286S	PTPRZ1_uc003vjz.2_Missense_Mutation_p.R1419S|PTPRZ1_uc011knt.1_Missense_Mutation_p.R876S	NM_002851	NP_002842	P23471	PTPRZ_HUMAN	protein tyrosine phosphatase, receptor-type,	2286	Cytoplasmic (Potential).				central nervous system development	integral to plasma membrane	protein binding|protein tyrosine/threonine phosphatase activity|transmembrane receptor protein tyrosine phosphatase activity			ovary(3)|large_intestine(2)|lung(2)|central_nervous_system(1)|kidney(1)	9						TGAGCACAAGGCAGGAAGAGA	0.443		NaN											1	0	8.16277e-20	0.006999	8.5714e-20	41	50									
NDUFA5	4698	broad.mit.edu	37	7	123197496	123197496	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr7:123197496C>T	uc003vks.2	-	2	137	c.28G>A	c.(28-30)GGC>AGC	p.G10S	NDUFA5_uc003vkr.2_RNA|NDUFA5_uc003vkt.1_Missense_Mutation_p.G10S	NM_005000	NP_004991	Q16718	NDUA5_HUMAN	NADH dehydrogenase (ubiquinone) 1 alpha	10					mitochondrial electron transport, NADH to ubiquinone|transport	mitochondrial respiratory chain complex I	NADH dehydrogenase (ubiquinone) activity				0					NADH(DB00157)	CCCACAAGGCCAGTGGTCTGT	0.438		NaN											0	0	0	0.010729	0	12	44									
SND1	27044	broad.mit.edu	37	7	127344995	127344995	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr7:127344995G>C	uc003vmi.2	+	8	1169	c.943G>C	c.(943-945)GAG>CAG	p.E315Q		NM_014390	NP_055205	Q7KZF4	SND1_HUMAN	staphylococcal nuclease domain containing 1	315	TNase-like 2.				gene silencing by RNA|interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription, DNA-dependent	melanosome|nucleus|RNA-induced silencing complex	nuclease activity|nucleic acid binding|protein binding|transcription cofactor activity			ovary(2)|central_nervous_system(1)	3						GAGGGCGGCAGAGAGGTAAGG	0.532		NaN											0	0	0	0.009096	0	4	35									
ZC3HC1	51530	broad.mit.edu	37	7	129691140	129691140	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr7:129691140G>A	uc003vpi.2	-	1	94	c.67C>T	c.(67-69)CGC>TGC	p.R23C		NM_016478	NP_057562	Q86WB0	NIPA_HUMAN	zinc finger, C3HC type 1	23					cell division|mitosis	nucleus	protein kinase binding|zinc ion binding				0	Melanoma(18;0.0435)					TCTGGGGAGCGAACTACTGCA	0.597		NaN											0	0	0	0.010729	0	12	69									
DGKI	9162	broad.mit.edu	37	7	137075986	137075986	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr7:137075986C>A	uc003vtt.2	-	34	3179	c.3178G>T	c.(3178-3180)GAC>TAC	p.D1060Y	DGKI_uc003vtu.2_Missense_Mutation_p.D729Y	NM_004717	NP_004708	O75912	DGKI_HUMAN	diacylglycerol kinase, iota	1060					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	nucleus|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			ovary(1)|kidney(1)|skin(1)	3						GTTTCCAGGTCCTCATGGCCA	0.527		NaN											1	0	2.12542e-12	0.00632	2.21335e-12	26	115									
EPHA1	2041	broad.mit.edu	37	7	143095738	143095738	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr7:143095738G>A	uc003wcz.2	-	6	1379	c.1292C>T	c.(1291-1293)TCT>TTT	p.S431F		NM_005232	NP_005223	P21709	EPHA1_HUMAN	ephrin receptor EphA1 precursor	431	Extracellular (Potential).|Fibronectin type-III 1.					integral to plasma membrane	ATP binding|ephrin receptor activity			ovary(3)|lung(1)|breast(1)	5	Melanoma(164;0.205)	Myeloproliferative disorder(862;0.0255)				GGCATGGCCAGAGCTGCCCAG	0.572		NaN											0	0	0	0.006214	0	10	60									
CUL1	8454	broad.mit.edu	37	7	148427336	148427336	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr7:148427336G>A	uc010lpg.2	+	2	648	c.122G>A	c.(121-123)AGA>AAA	p.R41K	CUL1_uc003wey.2_Missense_Mutation_p.R41K|CUL1_uc003wez.2_5'UTR	NM_003592	NP_003583	Q13616	CUL1_HUMAN	cullin 1	41					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell cycle arrest|G1/S transition of mitotic cell cycle|induction of apoptosis by intracellular signals|interspecies interaction between organisms|negative regulation of cell proliferation|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein ubiquitination|S phase of mitotic cell cycle|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	cytosol|nucleoplasm|SCF ubiquitin ligase complex	ubiquitin protein ligase binding			lung(1)	1	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00291)			GCCAAGTCCAGATATATGGAG	0.478		NaN											0	0	0	0.00245	0	14	89									
GIMAP8	155038	broad.mit.edu	37	7	150164398	150164398	+	Silent	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr7:150164398C>T	uc003whj.2	+	2	942	c.612C>T	c.(610-612)TTC>TTT	p.F204F		NM_175571	NP_783161	Q8ND71	GIMA8_HUMAN	GTPase, IMAP family member 8	204						endoplasmic reticulum|Golgi apparatus|mitochondrion	GTP binding			skin(3)|ovary(2)|breast(1)|central_nervous_system(1)	7			OV - Ovarian serous cystadenocarcinoma(82;0.0218)	UCEC - Uterine corpus endometrioid carcinoma (81;0.17)		ATGTGAACTTCAAAACTGAAG	0.408		NaN											0	0	0	0.008871	0	20	97									
CLN8	2055	broad.mit.edu	37	8	1728467	1728467	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr8:1728467C>T	uc003wpo.3	+	3	900	c.595C>T	c.(595-597)CAC>TAC	p.H199Y		NM_018941	NP_061764	Q9UBY8	CLN8_HUMAN	ceroid-lipofuscinosis, neuronal 8	199	TLC.				cell death|ceramide biosynthetic process|cholesterol metabolic process|lipid transport|negative regulation of proteolysis|phospholipid metabolic process	endoplasmic reticulum membrane|ER-Golgi intermediate compartment membrane|integral to membrane				ovary(1)|central_nervous_system(1)|skin(1)	3		Ovarian(12;0.0563)|Colorectal(14;0.0815)|Hepatocellular(245;0.0831)		BRCA - Breast invasive adenocarcinoma(11;7.67e-05)|READ - Rectum adenocarcinoma(644;0.0913)		GCTGATGATTCACATGTTTCA	0.517		NaN											0	0	0	0.013537	0	11	72									
ARHGEF10	9639	broad.mit.edu	37	8	1876813	1876813	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr8:1876813G>A	uc003wpr.2	+	24	3096	c.2918G>A	c.(2917-2919)GGA>GAA	p.G973E	ARHGEF10_uc003wps.2_Missense_Mutation_p.G935E|ARHGEF10_uc010lre.2_Missense_Mutation_p.G624E	NM_014629	NP_055444	O15013	ARHGA_HUMAN	Rho guanine nucleotide exchange factor 10	998					centrosome duplication|myelination in peripheral nervous system|positive regulation of GTP catabolic process|positive regulation of stress fiber assembly|regulation of Rho protein signal transduction|spindle assembly involved in mitosis	centrosome|cytosol|soluble fraction	kinesin binding|Rho guanyl-nucleotide exchange factor activity			large_intestine(1)	1		Colorectal(14;3.46e-05)|Renal(68;0.000518)|Ovarian(12;0.00409)|Myeloproliferative disorder(644;0.0255)|Hepatocellular(245;0.0834)		COAD - Colon adenocarcinoma(149;1.62e-05)|BRCA - Breast invasive adenocarcinoma(11;1.68e-05)|KIRC - Kidney renal clear cell carcinoma(542;0.00361)|READ - Rectum adenocarcinoma(644;0.0718)		ACGGAGGAGGGAAGGTAGGGC	0.617		NaN											0	0	0	0.001984	0	5	37									
DLC1	10395	broad.mit.edu	37	8	12947971	12947971	+	Silent	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr8:12947971C>T	uc003wwm.2	-	15	4308	c.3864G>A	c.(3862-3864)GAG>GAA	p.E1288E	DLC1_uc003wwk.1_Silent_p.E851E|DLC1_uc003wwl.1_Silent_p.E885E|DLC1_uc011kxx.1_Silent_p.E777E	NM_182643	NP_872584	Q96QB1	RHG07_HUMAN	deleted in liver cancer 1 isoform 1	1288					actin cytoskeleton organization|activation of caspase activity|focal adhesion assembly|forebrain development|heart morphogenesis|hindbrain morphogenesis|induction of apoptosis|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of Rho protein signal transduction|negative regulation of stress fiber assembly|neural tube closure|positive regulation of protein dephosphorylation|regulation of cell shape|small GTPase mediated signal transduction	caveola|cytosol|focal adhesion|nucleus	Rho GTPase activator activity|SH2 domain binding			ovary(3)|pancreas(2)|lung(1)|kidney(1)	7						GGCTCATTTCCTCGGGAACCT	0.517		NaN											0	0	0	0.013537	0	12	47									
PSD3	23362	broad.mit.edu	37	8	18729854	18729854	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr8:18729854C>T	uc003wza.2	-	3	623	c.520G>A	c.(520-522)GAC>AAC	p.D174N		NM_015310	NP_056125	Q9NYI0	PSD3_HUMAN	ADP-ribosylation factor guanine nucleotide	174					regulation of ARF protein signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	ARF guanyl-nucleotide exchange factor activity			ovary(3)	3				Colorectal(111;0.0281)|READ - Rectum adenocarcinoma(644;0.183)		CTGGCAGTGTCCAGCTCTTTT	0.443		NaN											0	0	0	0.009535	0	21	118									
CSGALNACT1	55790	broad.mit.edu	37	8	19316071	19316071	+	Silent	SNP	G	G	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr8:19316071G>T	uc011kyn.1	-	5	1781	c.717C>A	c.(715-717)CTC>CTA	p.L239L	CSGALNACT1_uc011kyo.1_Silent_p.L239L|CSGALNACT1_uc003wzg.2_RNA|CSGALNACT1_uc011kyp.1_Silent_p.L238L|CSGALNACT1_uc003wzh.2_RNA	NM_001130518	NP_001123990	Q8TDX6	CGAT1_HUMAN	chondroitin sulfate	239	Lumenal (Potential).				anatomical structure morphogenesis|cell proliferation|cell recognition|chondroitin sulfate biosynthetic process|chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process|dermatan sulfate proteoglycan biosynthetic process|extracellular matrix organization|heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process|heparin biosynthetic process|nervous system development|UDP-glucuronate metabolic process|UDP-N-acetylgalactosamine metabolic process	Golgi cisterna membrane|integral to Golgi membrane|soluble fraction	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity|glucuronosyltransferase activity|glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity|metal ion binding|peptidoglycan glycosyltransferase activity			central_nervous_system(2)|ovary(1)	3				Colorectal(111;0.182)		GAAATAAGATGAGCCGTTTGA	0.433		NaN											1	0	1.87469e-40	0.01441	1.99469e-40	61	200									
REEP4	80346	broad.mit.edu	37	8	21997685	21997685	+	Nonsense_Mutation	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr8:21997685C>T	uc003xau.1	-	3	635	c.182G>A	c.(181-183)TGG>TAG	p.W61*	REEP4_uc010ltt.1_Nonsense_Mutation_p.W61*|REEP4_uc011kyz.1_Nonsense_Mutation_p.W61*	NM_025232	NP_079508	Q9H6H4	REEP4_HUMAN	receptor accessory protein 4	61	Helical; (Potential).					integral to membrane				skin(1)	1				Colorectal(74;0.00187)|COAD - Colon adenocarcinoma(73;0.061)|READ - Rectum adenocarcinoma(644;0.0993)		GCGTCCATACCAGGAGATAAA	0.577		NaN											0	0	0	0.000602	0	4	15									
EGR3	1960	broad.mit.edu	37	8	22548114	22548114	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr8:22548114C>G	uc003xcm.1	-	2	1394	c.1036G>C	c.(1036-1038)GAC>CAC	p.D346H	EGR3_uc011kzn.1_Missense_Mutation_p.D308H|EGR3_uc011kzo.1_Missense_Mutation_p.D292H	NM_004430	NP_004421	Q06889	EGR3_HUMAN	early growth response 3	346	C2H2-type 3.				circadian rhythm|muscle organ development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Prostate(55;0.0421)|Breast(100;0.102)		Colorectal(74;0.0145)|BRCA - Breast invasive adenocarcinoma(99;0.053)|COAD - Colon adenocarcinoma(73;0.0608)		TTGCGCTCGTCGCTGCGCGCA	0.647		NaN											0	0	0	0.003163	0	11	39									
GTF2E2	2961	broad.mit.edu	37	8	30472223	30472223	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr8:30472223G>A	uc003xig.2	-	4	521	c.268C>T	c.(268-270)CAG>TAG	p.Q90*		NM_002095	NP_002086	P29084	T2EB_HUMAN	general transcription factor IIE, polypeptide 2,	90	TFIIE beta.				regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	transcription factor TFIIE complex	DNA binding|protein binding				0				KIRC - Kidney renal clear cell carcinoma(542;0.113)|Kidney(114;0.135)		TCTCCTCGCTGATGCCGTGTC	0.358		NaN											0	0	0	0.010504	0	21	73									
DDHD2	23259	broad.mit.edu	37	8	38090714	38090714	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr8:38090714G>A	uc003xlb.2	+	2	579	c.202G>A	c.(202-204)GAA>AAA	p.E68K	DDHD2_uc003xla.2_Missense_Mutation_p.E68K|DDHD2_uc003xlc.2_Missense_Mutation_p.E68K|DDHD2_uc011lbl.1_5'UTR	NM_015214	NP_056029	O94830	DDHD2_HUMAN	DDHD domain containing 2 isoform 1	68	WWE.				lipid catabolic process	centrosome	hydrolase activity|metal ion binding			large_intestine(1)|ovary(1)	2	Colorectal(12;0.000442)	all_lung(54;0.0657)|Lung NSC(58;0.175)	BRCA - Breast invasive adenocarcinoma(5;3.76e-25)|COAD - Colon adenocarcinoma(9;0.0977)			ACAGCAGCTGGAAGAGGCATA	0.388		NaN											0	0	0	0.006122	0	18	76									
MCM4	4173	broad.mit.edu	37	8	48888324	48888324	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr8:48888324G>C	uc003xqk.1	+	16	2510	c.2415G>C	c.(2413-2415)TTG>TTC	p.L805F	MCM4_uc003xql.1_Missense_Mutation_p.L805F|MCM4_uc011ldi.1_Missense_Mutation_p.L792F	NM_182746	NP_877423	P33991	MCM4_HUMAN	minichromosome maintenance complex component 4	805					cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	MCM complex	ATP binding|DNA binding|helicase activity|protein binding			ovary(2)|skin(2)	4		all_cancers(86;0.026)|all_epithelial(80;0.000748)|Lung NSC(129;0.00327)|all_lung(136;0.00354)				CTGAAGCATTGAAAAAGCTTA	0.328		NaN											0	0	0	0.013537	0	13	58									
CHD7	55636	broad.mit.edu	37	8	61748694	61748694	+	Nonsense_Mutation	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr8:61748694C>T	uc003xue.2	+	16	4318	c.3841C>T	c.(3841-3843)CAG>TAG	p.Q1281*		NM_017780	NP_060250	Q9P2D1	CHD7_HUMAN	chromodomain helicase DNA binding protein 7	1281					central nervous system development|chromatin modification|cognition|cranial nerve development|face development|heart morphogenesis|in utero embryonic development|inner ear morphogenesis|nose development|palate development|regulation of growth hormone secretion|regulation of transcription, DNA-dependent|retina development in camera-type eye|skeletal system development|T cell differentiation|transcription, DNA-dependent	nucleus	ATP binding|chromatin binding|DNA binding|helicase activity			ovary(4)|large_intestine(1)|central_nervous_system(1)|lung(1)|breast(1)|pancreas(1)	9		all_cancers(86;0.2)|all_lung(136;0.0402)|Lung NSC(129;0.0459)|all_epithelial(80;0.0477)	BRCA - Breast invasive adenocarcinoma(89;0.143)			TCCAGATTTTCAGCTCCAGGC	0.458		NaN											0	0	0	0.001855	0	14	13									
ZFHX4	79776	broad.mit.edu	37	8	77618332	77618332	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr8:77618332C>T	uc003yav.2	+	2	2396	c.2009C>T	c.(2008-2010)CCG>CTG	p.P670L	ZFHX4_uc003yat.1_Missense_Mutation_p.P670L|ZFHX4_uc003yau.1_Missense_Mutation_p.P670L|ZFHX4_uc003yaw.1_Missense_Mutation_p.P670L	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	670						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			CACCCTGAGCCGGGTGGCTCT	0.507		NaN								HNSCC(33;0.089)			0	0	0	0.001168	0	5	39									
MMP16	4325	broad.mit.edu	37	8	89179976	89179976	+	Missense_Mutation	SNP	A	A	G			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr8:89179976A>G	uc003yeb.3	-	4	913	c.631T>C	c.(631-633)TTC>CTC	p.F211L	MMP16_uc003yec.2_Missense_Mutation_p.F211L	NM_005941	NP_005932	P51512	MMP16_HUMAN	matrix metalloproteinase 16 isoform 1	211	Extracellular (Potential).				collagen catabolic process|proteolysis	cell surface|integral to plasma membrane|proteinaceous extracellular matrix	calcium ion binding|enzyme activator activity|metalloendopeptidase activity|zinc ion binding			upper_aerodigestive_tract(2)|ovary(2)|central_nervous_system(1)|urinary_tract(1)|skin(1)|kidney(1)	8						GGTCCAGGGAAGTAGGCATGT	0.438		NaN											0	0	0	0.008871	0	19	102									
NBN	4683	broad.mit.edu	37	8	90955531	90955531	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr8:90955531G>A	uc003yej.1	-	14	2244	c.2134C>T	c.(2134-2136)CAT>TAT	p.H712Y	NBN_uc003yei.1_Missense_Mutation_p.H630Y|NBN_uc011lgb.1_Missense_Mutation_p.H712Y	NM_002485	NP_002476	O60934	NBN_HUMAN	nibrin	712					cell cycle arrest|DNA damage response, signal transduction by p53 class mediator|DNA duplex unwinding|double-strand break repair via homologous recombination|meiosis|mitotic cell cycle G1/S transition checkpoint|mitotic cell cycle G2/M transition DNA damage checkpoint|positive regulation of kinase activity|positive regulation of protein autophosphorylation|regulation of DNA-dependent DNA replication initiation|telomere maintenance	Mre11 complex|nuclear chromosome, telomeric region|nuclear inclusion body|nucleolus|nucleoplasm	protein N-terminus binding|transcription factor binding			central_nervous_system(3)|kidney(3)|lung(1)	7			BRCA - Breast invasive adenocarcinoma(11;0.0344)			TTTCGAGCATGATGAGCTATT	0.393		NaN						Direct_reversal_of_damage|Homologous_recombination	Nijmegen_Breakage_syndrome				0	0	0	0.01441	0	114	87									
ESRP1	54845	broad.mit.edu	37	8	95653664	95653664	+	Silent	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr8:95653664C>T	uc003ygq.3	+	1	301	c.118C>T	c.(118-120)CTG>TTG	p.L40L	ESRP1_uc003ygr.3_Silent_p.L40L|ESRP1_uc003ygs.3_Silent_p.L40L|ESRP1_uc003ygt.3_Silent_p.L40L|ESRP1_uc003ygu.3_Silent_p.L40L	NM_017697	NP_060167	Q6NXG1	ESRP1_HUMAN	RNA binding motif protein 35A isoform 1	40					mRNA processing|regulation of RNA splicing|RNA splicing	nucleus|plasma membrane	mRNA binding|nucleotide binding		ESRP1/RAF1(4)	prostate(4)	4						AGTCGTGGATCTGGCCAACAA	0.527		NaN											0	0	0	0.01441	0	46	37									
TMEM74	157753	broad.mit.edu	37	8	109797208	109797208	+	Silent	SNP	G	G	C			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr8:109797208G>C	uc003ymy.1	-	2	225	c.120C>G	c.(118-120)CTC>CTG	p.L40L	TMEM74_uc003ymx.2_Intron	NM_153015	NP_694560	Q96NL1	TMM74_HUMAN	transmembrane protein 74	40					autophagy	autophagic vacuole membrane|cytoplasmic vesicle|integral to membrane|lysosomal membrane				ovary(1)|lung(1)|kidney(1)|skin(1)	4			OV - Ovarian serous cystadenocarcinoma(57;3.08e-10)			TCTGACAGCAGAGAGCAGCTC	0.542		NaN											0	0	0	0.007413	0	18	121									
ANXA13	312	broad.mit.edu	37	8	124693585	124693585	+	Silent	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr8:124693585C>T	uc003yqu.2	-	11	919	c.846G>A	c.(844-846)GGG>GGA	p.G282G	ANXA13_uc003yqt.2_Silent_p.G323G	NM_004306	NP_004297	P27216	ANX13_HUMAN	annexin A13 isoform a	282	Annexin 4.				cell differentiation	plasma membrane	calcium ion binding|calcium-dependent phospholipid binding			ovary(1)|pancreas(1)|skin(1)	3	Lung NSC(37;2.06e-11)|Ovarian(258;0.00579)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00288)			TTGCTTTGATCCCCTGAAGGT	0.343		NaN											0	0	0	0.01441	0	140	129									
COL22A1	169044	broad.mit.edu	37	8	139629181	139629181	+	Silent	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr8:139629181G>A	uc003yvd.2	-	54	4293	c.3846C>T	c.(3844-3846)GGC>GGT	p.G1282G	COL22A1_uc011ljo.1_Silent_p.G562G	NM_152888	NP_690848	Q8NFW1	COMA1_HUMAN	collagen, type XXII, alpha 1	1282	Pro-rich.|Gly-rich.|Collagen-like 12.				cell adhesion	collagen|cytoplasm	structural molecule activity			ovary(11)|pancreas(1)|skin(1)	13	all_epithelial(106;1.55e-12)|Lung NSC(106;1.67e-05)|all_lung(105;3.39e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0517)			CACCAGAATCGCCTGTGTGTC	0.587		NaN								HNSCC(7;0.00092)			0	0	0	0.01441	0	64	37									
CPSF1	29894	broad.mit.edu	37	8	145622704	145622704	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr8:145622704C>T	uc003zcj.2	-	22	2458	c.2383G>A	c.(2383-2385)GAG>AAG	p.E795K		NM_013291	NP_037423	Q10570	CPSF1_HUMAN	cleavage and polyadenylation specific factor 1,	795					mRNA cleavage|mRNA export from nucleus|mRNA polyadenylation|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	mRNA cleavage and polyadenylation specificity factor complex	mRNA 3'-UTR binding|protein binding			skin(1)	1	all_cancers(97;6.64e-12)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.88e-41)|Epithelial(56;1.67e-40)|all cancers(56;1.2e-35)|BRCA - Breast invasive adenocarcinoma(115;0.0323)|Colorectal(110;0.055)			CCACCTACCTCCATGGTGCCA	0.682		NaN											0	0	0	0.010729	0	12	9									
ZNF7	7553	broad.mit.edu	37	8	146068042	146068042	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr8:146068042G>A	uc003zeg.3	+	5	1687	c.1550G>A	c.(1549-1551)AGA>AAA	p.R517K	ZNF7_uc010mge.2_Missense_Mutation_p.R528K|ZNF7_uc011lln.1_Missense_Mutation_p.R421K|ZNF7_uc003zeh.2_Intron|ZNF7_uc003zek.3_Missense_Mutation_p.R421K|COMMD5_uc003zel.1_Intron	NM_003416	NP_003407	P17097	ZNF7_HUMAN	zinc finger protein 7	517	C2H2-type 10.				multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(4)	4	all_cancers(97;1.03e-11)|all_epithelial(106;6.69e-11)|Lung NSC(106;4.08e-05)|all_lung(105;0.000125)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)	Breast(495;0.0812)|Ovarian(118;0.0822)|Acute lymphoblastic leukemia(644;0.143)	Epithelial(56;8.75e-39)|OV - Ovarian serous cystadenocarcinoma(54;1.13e-38)|all cancers(56;8.48e-34)|BRCA - Breast invasive adenocarcinoma(115;0.0355)|Colorectal(110;0.055)	GBM - Glioblastoma multiforme(99;2.11e-07)		TACCATCAGAGAATCCATAAA	0.453		NaN											0	0	0	0.001855	0	14	102									
C8orf33	65265	broad.mit.edu	37	8	146279413	146279413	+	Nonsense_Mutation	SNP	C	C	G			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr8:146279413C>G	uc003zfc.3	+	5	614	c.560C>G	c.(559-561)TCA>TGA	p.S187*	C8orf33_uc003zfd.2_RNA	NM_023080	NP_075568	Q9H7E9	CH033_HUMAN	hypothetical protein LOC65265	187											0	all_cancers(97;8.72e-12)|all_epithelial(106;1.07e-10)|Lung NSC(106;7.18e-05)|all_lung(105;0.00021)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		Epithelial(56;9.1e-38)|all cancers(56;7.37e-33)|BRCA - Breast invasive adenocarcinoma(115;0.0424)|Colorectal(110;0.055)	GBM - Glioblastoma multiforme(99;0.243)		GCTGCTTATTCAGCCCAGGTG	0.393		NaN											0	0	0	0.01441	0	160	148									
DOCK8	81704	broad.mit.edu	37	9	422091	422091	+	Silent	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr9:422091G>A	uc003zgf.2	+	33	4309	c.4197G>A	c.(4195-4197)AAG>AAA	p.K1399K	DOCK8_uc010mgu.2_Silent_p.K701K|DOCK8_uc010mgv.2_Silent_p.K1299K|DOCK8_uc003zgk.2_Silent_p.K857K	NM_203447	NP_982272	Q8NF50	DOCK8_HUMAN	dedicator of cytokinesis 8	1399	DHR-2.				blood coagulation	cytosol	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			ovary(3)|central_nervous_system(3)	6		all_cancers(5;2.13e-17)|all_epithelial(5;2.15e-12)|all_lung(10;6.69e-11)|Lung NSC(10;1.08e-10)|Acute lymphoblastic leukemia(5;0.000242)|all_hematologic(5;0.00317)|Breast(48;0.0151)|Prostate(43;0.128)		all cancers(5;9.3e-07)|GBM - Glioblastoma multiforme(5;2.41e-06)|Epithelial(6;0.00557)|Lung(218;0.00942)		TGAGATGGAAGAAAGAGCAGA	0.398		NaN											0	0	0	0.012319	0	17	24									
DOCK8	81704	broad.mit.edu	37	9	429848	429848	+	Silent	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr9:429848C>T	uc003zgf.2	+	36	4732	c.4620C>T	c.(4618-4620)GCC>GCT	p.A1540A	DOCK8_uc010mgu.2_Silent_p.A842A|DOCK8_uc010mgv.2_Silent_p.A1440A|DOCK8_uc003zgk.2_Silent_p.A998A	NM_203447	NP_982272	Q8NF50	DOCK8_HUMAN	dedicator of cytokinesis 8	1540	DHR-2.				blood coagulation	cytosol	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			ovary(3)|central_nervous_system(3)	6		all_cancers(5;2.13e-17)|all_epithelial(5;2.15e-12)|all_lung(10;6.69e-11)|Lung NSC(10;1.08e-10)|Acute lymphoblastic leukemia(5;0.000242)|all_hematologic(5;0.00317)|Breast(48;0.0151)|Prostate(43;0.128)		all cancers(5;9.3e-07)|GBM - Glioblastoma multiforme(5;2.41e-06)|Epithelial(6;0.00557)|Lung(218;0.00942)		GTTTTGGAGCCACCAGTGTAA	0.468		NaN											0	0	0	0.00499	0	18	27									
RFK	55312	broad.mit.edu	37	9	79002362	79002362	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr9:79002362C>T	uc004akd.2	-	4	778	c.442G>A	c.(442-444)GAC>AAC	p.D148N	RFK_uc004ake.2_3'UTR	NM_018339	NP_060809	Q969G6	RIFK_HUMAN	riboflavin kinase	141					riboflavin biosynthetic process	cytosol	ATP binding|metal ion binding|riboflavin kinase activity				0					Riboflavin(DB00140)	AAGAAATTGTCTTCTTTGATT	0.313		NaN											0	0	0	0.01441	0	70	108									
FAM22F	54754	broad.mit.edu	37	9	97082700	97082700	+	Silent	SNP	G	G	C			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr9:97082700G>C	uc004aup.1	-	5	1179	c.1158C>G	c.(1156-1158)GTC>GTG	p.V386V		NM_017561	NP_060031	A1L443	FA22F_HUMAN	hypothetical protein LOC54754	386	Pro-rich.										0		Acute lymphoblastic leukemia(62;0.136)				TCTCCTCAGGGACCTTGGTCT	0.667		NaN											0	0	0	0.013726	0	30	40									
SNX30	401548	broad.mit.edu	37	9	115598511	115598511	+	Silent	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr9:115598511G>A	uc004bgj.3	+	5	784	c.636G>A	c.(634-636)AAG>AAA	p.K212K	SNX30_uc004bgi.3_5'Flank	NM_001012994	NP_001013012	Q5VWJ9	SNX30_HUMAN	sorting nexin family member 30	212					cell communication|protein transport	cytoplasm	phosphatidylinositol binding				0						ACGCCTACAAGAAGCAAGGGA	0.498		NaN											0	0	0	0.012319	0	23	163									
ZFP37	7539	broad.mit.edu	37	9	115805331	115805331	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr9:115805331C>G	uc004bgm.1	-	4	1595	c.1567G>C	c.(1567-1569)GGG>CGG	p.G523R	ZFP37_uc011lwz.1_Missense_Mutation_p.G538R|ZFP37_uc011lxa.1_Missense_Mutation_p.G524R	NM_003408	NP_003399	Q9Y6Q3	ZFP37_HUMAN	zinc finger protein 37 homolog	523	C2H2-type 9.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|skin(1)	2						AAGCCTTTCCCACATTGATTA	0.388		NaN											0	0	0	0.005524	0	39	77									
COL27A1	85301	broad.mit.edu	37	9	117027210	117027210	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr9:117027210C>G	uc011lxl.1	+	30	3256	c.3256C>G	c.(3256-3258)CCA>GCA	p.P1086A	COL27A1_uc004bii.2_RNA	NM_032888	NP_116277	Q8IZC6	CORA1_HUMAN	collagen, type XXVII, alpha 1 precursor	1086	Pro-rich.|Collagen-like 8.|Triple-helical region.				cell adhesion		extracellular matrix structural constituent			ovary(3)|skin(1)	4						ACAGGGCCCTCCAGGACCCCA	0.612		NaN											0	0	0	0.010771	0	39	42									
FAM125B	89853	broad.mit.edu	37	9	129157918	129157918	+	Nonsense_Mutation	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr9:129157918C>T	uc004bqh.1	+	6	685	c.604C>T	c.(604-606)CAA>TAA	p.Q202*	FAM125B_uc004bqg.1_Nonsense_Mutation_p.Q202*|FAM125B_uc011lzy.1_Nonsense_Mutation_p.Q187*|FAM125B_uc010mxd.2_Nonsense_Mutation_p.Q195*|FAM125B_uc011lzz.1_Nonsense_Mutation_p.Q195*	NM_033446	NP_258257	Q9H7P6	F125B_HUMAN	hypothetical protein LOC89853 isoform 1	202					protein transport	late endosome membrane					0						TGACTCATCTCAACCCACAAC	0.522		NaN											0	0	0	0.004656	0	26	143									
RALGPS1	9649	broad.mit.edu	37	9	129958857	129958857	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr9:129958857G>A	uc004bqo.1	+	13	1409	c.1142G>A	c.(1141-1143)CGA>CAA	p.R381Q	RALGPS1_uc011mac.1_Intron|RALGPS1_uc004bqq.3_Intron	NM_014636	NP_055451	Q5JS13	RGPS1_HUMAN	Ral GEF with PH domain and SH3 binding motif 1	381					small GTPase mediated signal transduction	cytoplasm|plasma membrane	guanyl-nucleotide exchange factor activity			ovary(1)	1						CGCAGCCCCCGAAGGGGCCTG	0.577		NaN											0	0	0	0.01441	0	61	47									
CRAT	1384	broad.mit.edu	37	9	131864290	131864290	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr9:131864290G>A	uc004bxh.2	-	6	959	c.677C>T	c.(676-678)GCG>GTG	p.A226V	CRAT_uc004bxg.2_Missense_Mutation_p.A205V|CRAT_uc004bxk.3_Missense_Mutation_p.A205V	NM_000755	NP_000746	P43155	CACP_HUMAN	carnitine acetyltransferase precursor	226					energy derivation by oxidation of organic compounds|fatty acid beta-oxidation using acyl-CoA oxidase|transport	endoplasmic reticulum|mitochondrial inner membrane|peroxisomal matrix	carnitine O-acetyltransferase activity			central_nervous_system(1)	1				UCEC - Uterine corpus endometrioid carcinoma (4;0.0178)	L-Carnitine(DB00583)	GATCTGATCCGCAGTGAGGGG	0.567		NaN											0	0	0	0.009096	0	4	38									
ABL1	25	broad.mit.edu	37	9	133760298	133760298	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr9:133760298G>A	uc004bzw.2	+	11	2624	c.2621G>A	c.(2620-2622)AGA>AAA	p.R874K	ABL1_uc004bzv.2_Missense_Mutation_p.R893K	NM_005157	NP_005148	P00519	ABL1_HUMAN	c-abl oncogene 1, receptor tyrosine kinase	874	DNA-binding (By similarity).|Pro-rich.				actin cytoskeleton organization|axon guidance|blood coagulation|cell adhesion|DNA damage induced protein phosphorylation|DNA damage response, signal transduction resulting in induction of apoptosis|mismatch repair|muscle cell differentiation|negative regulation of protein serine/threonine kinase activity|peptidyl-tyrosine phosphorylation|positive regulation of muscle cell differentiation|positive regulation of oxidoreductase activity|regulation of transcription involved in S phase of mitotic cell cycle	cytoskeleton|cytosol|nuclear membrane|nucleolus|perinuclear region of cytoplasm	ATP binding|DNA binding|magnesium ion binding|manganese ion binding|mitogen-activated protein kinase binding|non-membrane spanning protein tyrosine kinase activity|proline-rich region binding|protein C-terminus binding|SH3 domain binding			haematopoietic_and_lymphoid_tissue(807)|lung(5)|stomach(2)|central_nervous_system(1)|breast(1)|skin(1)	817		all_hematologic(13;0.0361)|Acute lymphoblastic leukemia(5;0.0543)|Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;5.4e-05)	Adenosine triphosphate(DB00171)|Dasatinib(DB01254)|Imatinib(DB00619)	GAGGAGTCCAGAGTGAGGAGG	0.667		NaN	T|Mis	BCR|ETV6|NUP214	CML|ALL|T-ALL								0	0	0	0.001984	0	5	12									
RAPGEF1	2889	broad.mit.edu	37	9	134454941	134454941	+	Silent	SNP	C	C	G			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr9:134454941C>G	uc004cbc.2	-	24	3307	c.3177G>C	c.(3175-3177)CTG>CTC	p.L1059L	RAPGEF1_uc004cbb.2_Silent_p.L1077L	NM_005312	NP_005303	Q13905	RPGF1_HUMAN	guanine nucleotide-releasing factor 2 isoform a	1059	Ras-GEF.				activation of MAPKK activity|nerve growth factor receptor signaling pathway|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|endosome	guanyl-nucleotide exchange factor activity|SH3 domain binding			lung(3)|ovary(2)|breast(1)|skin(1)	7		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;2.19e-05)|Epithelial(140;0.000364)		GTTTAATTTTCAGAGACAGTT	0.517		NaN											0	0	0	0.003271	0	34	148									
MED27	9442	broad.mit.edu	37	9	134952861	134952861	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr9:134952861G>C	uc004cbe.1	-	2	338	c.316C>G	c.(316-318)CAA>GAA	p.Q106E	MED27_uc004cbf.1_Missense_Mutation_p.Q106E|MED27_uc011mco.1_Missense_Mutation_p.Q106E|MED27_uc004cbg.3_Missense_Mutation_p.Q106E	NM_004269	NP_004260	Q6P2C8	MED27_HUMAN	mediator complex subunit 27	106					regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	cytoplasm|nucleolus|transcription factor complex	protein binding|transcription coactivator activity			skin(1)	1		Myeloproliferative disorder(178;0.206)		OV - Ovarian serous cystadenocarcinoma(145;6.82e-06)|Epithelial(140;0.000193)		TGAAGGAGTTGACTATAGAGA	0.418		NaN											0	0	0	0.01441	0	43	213									
TSC1	7248	broad.mit.edu	37	9	135781419	135781419	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr9:135781419G>A	uc004cca.2	-	15	1780	c.1546C>T	c.(1546-1548)CAG>TAG	p.Q516*	TSC1_uc004ccb.3_Nonsense_Mutation_p.Q515*|TSC1_uc011mcq.1_Nonsense_Mutation_p.Q465*|TSC1_uc011mcr.1_Intron	NM_000368	NP_000359	Q92574	TSC1_HUMAN	tuberous sclerosis 1 protein isoform 1	516					activation of Rho GTPase activity|cell cycle arrest|cell-matrix adhesion|insulin receptor signaling pathway|negative regulation of cell proliferation|negative regulation of protein ubiquitination|negative regulation of TOR signaling cascade|negative regulation of translation|positive regulation of focal adhesion assembly|regulation of phosphoprotein phosphatase activity|regulation of stress fiber assembly|rRNA export from nucleus	cell cortex|lamellipodium|membrane|TSC1-TSC2 complex	chaperone binding|protein N-terminus binding	p.?(1)		lung(4)|central_nervous_system(3)|breast(2)|haematopoietic_and_lymphoid_tissue(1)|urinary_tract(1)|skin(1)|ovary(1)|bone(1)	14				OV - Ovarian serous cystadenocarcinoma(145;4.32e-08)|Epithelial(140;2.72e-06)		GTCTTCCGCTGAGAACCTGGG	0.567		NaN	D|Mis|N|F|S			hamartoma|renal cell			Tuberous_Sclerosis				0	0	0	0.010504	0	21	19									
FCN2	2220	broad.mit.edu	37	9	137777709	137777709	+	Silent	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr9:137777709G>A	uc004cfg.1	+	6	535	c.525G>A	c.(523-525)CTG>CTA	p.L175L	FCN2_uc004cfh.1_Silent_p.L137L	NM_004108	NP_004099	Q15485	FCN2_HUMAN	ficolin 2 isoform a precursor	175	Fibrinogen C-terminal.				complement activation, lectin pathway|opsonization|signal transduction	collagen|extracellular space	antigen binding|calcium ion binding|calcium-dependent protein binding|receptor binding|sugar binding			large_intestine(1)	1		Myeloproliferative disorder(178;0.0333)		OV - Ovarian serous cystadenocarcinoma(145;3.58e-08)|Epithelial(140;6.41e-08)|all cancers(34;3.96e-07)		AGTTCTGGCTGGGGAATGACA	0.672		NaN											0	0	0	0.004656	0	26	24									
FCN1	2219	broad.mit.edu	37	9	137804336	137804336	+	Silent	SNP	G	G	C			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr9:137804336G>C	uc004cfi.2	-	7	686	c.594C>G	c.(592-594)GCC>GCG	p.A198A		NM_002003	NP_001994	O00602	FCN1_HUMAN	ficolin 1 precursor	198	Fibrinogen C-terminal.				opsonization|signal transduction	collagen|extracellular space	antigen binding|calcium ion binding|receptor binding|sugar binding			large_intestine(1)|ovary(1)	2		Myeloproliferative disorder(178;0.0333)		OV - Ovarian serous cystadenocarcinoma(145;3.46e-08)|Epithelial(140;6.01e-08)|all cancers(34;3.69e-07)		CCCTACCCTGGGCAGTCAGGG	0.642		NaN											0	0	0	0.001168	0	4	13									
IL3RA	3563	broad.mit.edu	37	X	1475113	1475113	+	Splice_Site	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chrX:1475113G>A	uc004cps.2	+	7	966	c.617_splice	c.e7-1	p.E206_splice	IL3RA_uc011mhd.1_Splice_Site_p.E128_splice	NM_002183	NP_002174	P26951	IL3RA_HUMAN	interleukin 3 receptor, alpha precursor							integral to membrane|plasma membrane	interleukin-3 receptor activity			skin(2)|lung(1)	3		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)			Sargramostim(DB00020)	CTCGTTGCTAGAGATATTAAC	0.328		NaN											0	0	0	0.01441	0	52	171									
MXRA5	25878	broad.mit.edu	37	X	3239350	3239350	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chrX:3239350G>A	uc004crg.3	-	5	4533	c.4376C>T	c.(4375-4377)ACC>ATC	p.T1459I		NM_015419	NP_056234	Q9NR99	MXRA5_HUMAN	adlican precursor	1459						extracellular region				ovary(5)|lung(1)|central_nervous_system(1)|skin(1)	8		all_lung(23;0.00031)|Lung NSC(23;0.000946)				TTGATCAAGGGTGGTGGTTTC	0.488		NaN											0	0	0	0.00623	0	40	32									
ARHGAP6	395	broad.mit.edu	37	X	11272742	11272742	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chrX:11272742G>A	uc004cup.1	-	2	1547	c.674C>T	c.(673-675)GCC>GTC	p.A225V	ARHGAP6_uc004cuo.1_RNA|ARHGAP6_uc004cur.1_Missense_Mutation_p.A225V|ARHGAP6_uc004cum.1_Missense_Mutation_p.A22V|ARHGAP6_uc004cun.1_Missense_Mutation_p.A45V|ARHGAP6_uc010neb.1_Missense_Mutation_p.A47V|ARHGAP6_uc011mif.1_Missense_Mutation_p.A22V	NM_013427	NP_038286	O43182	RHG06_HUMAN	Rho GTPase activating protein 6 isoform 1	225					actin filament polymerization|activation of phospholipase C activity|negative regulation of focal adhesion assembly|negative regulation of stress fiber assembly|Rho protein signal transduction	actin filament|cytosol	phospholipase activator activity|phospholipase binding|Rho GTPase activator activity|SH3 domain binding|SH3/SH2 adaptor activity			urinary_tract(1)|lung(1)	2						CTGCAGCCGGGCCCTCTCCAG	0.547		NaN											0	0	0	0.005443	0	27	29									
MAGEB10	139422	broad.mit.edu	37	X	27840056	27840056	+	Silent	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chrX:27840056C>T	uc004dbw.2	+	3	860	c.633C>T	c.(631-633)ATC>ATT	p.I211I		NM_182506	NP_872312	Q96LZ2	MAGBA_HUMAN	melanoma antigen family B, 10	211	MAGE.									lung(1)|breast(1)|central_nervous_system(1)	3						TGGGTATTATCTTCACAAATG	0.473		NaN											0	0	0	0.003163	0	15	38									
ARAF	369	broad.mit.edu	37	X	47422403	47422403	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chrX:47422403G>A	uc011mlq.1	+	2	170	c.37G>A	c.(37-39)GAG>AAG	p.E13K	ARAF_uc011mln.1_RNA|ARAF_uc011mlo.1_5'UTR|ARAF_uc011mlp.1_Missense_Mutation_p.E13K|ARAF_uc004dic.1_5'Flank	NM_001654	NP_001645	P10398	ARAF_HUMAN	v-raf murine sarcoma 3611 viral oncogene	13					intracellular signal transduction|negative regulation of apoptosis|positive regulation of peptidyl-serine phosphorylation		ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|receptor signaling protein activity			large_intestine(3)|lung(2)|ovary(1)|skin(1)	7					Adenosine triphosphate(DB00171)	CAATGGGGCCGAGCCATCCCG	0.627		NaN									OREG0019758	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.009096	0	4	3									
GNL3L	54552	broad.mit.edu	37	X	54569458	54569458	+	Missense_Mutation	SNP	A	A	G			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chrX:54569458A>G	uc004dth.1	+	6	516	c.377A>G	c.(376-378)AAG>AGG	p.K126R	GNL3L_uc004dti.2_RNA	NM_019067	NP_061940	Q9NVN8	GNL3L_HUMAN	guanine nucleotide binding protein-like 3	126					ribosome biogenesis	nucleolus	GTP binding			ovary(1)	1						GCTTATTACAAGGAGTTCCGT	0.453		NaN											0	0	0	0.00278	0	23	15									
LAS1L	81887	broad.mit.edu	37	X	64753613	64753613	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chrX:64753613G>A	uc004dwa.1	-	2	311	c.239C>T	c.(238-240)TCA>TTA	p.S80L	LAS1L_uc004dwc.1_Missense_Mutation_p.S80L|LAS1L_uc004dwd.1_Intron	NM_031206	NP_112483	Q9Y4W2	LAS1L_HUMAN	LAS1-like	80						MLL1 complex|nucleolus	protein binding			ovary(3)|large_intestine(1)	4						TTCGTTGCCTGACCTAAAGGG	0.517		NaN											0	0	0	0.009535	0	23	17									
DIAPH2	1730	broad.mit.edu	37	X	96136711	96136711	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chrX:96136711C>T	uc004efu.3	+	5	977	c.581C>T	c.(580-582)CCG>CTG	p.P194L	DIAPH2_uc004eft.3_Missense_Mutation_p.P194L|DIAPH2_uc004efs.2_Missense_Mutation_p.P201L|RPA4_uc004efv.3_5'Flank	NM_006729	NP_006720	O60879	DIAP2_HUMAN	diaphanous 2 isoform 156	194	GBD/FH3.				cell differentiation|cytokinesis|multicellular organismal development|oogenesis	cytosol|early endosome|Golgi apparatus|mitochondrion|nucleolus	receptor binding|Rho GTPase binding			ovary(3)|lung(1)	4						ACCAGCAATCCGGTCAGGTAA	0.343		NaN											0	0	0	0.01441	0	51	33									
BTK	695	broad.mit.edu	37	X	100608277	100608277	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chrX:100608277C>T	uc004ehg.2	-	18	2006	c.1813G>A	c.(1813-1815)GAG>AAG	p.E605K	BTK_uc004ehf.2_Missense_Mutation_p.E105K|BTK_uc010nnh.2_RNA|BTK_uc010nni.2_Intron|BTK_uc004ehe.2_RNA|BTK_uc010nnj.2_RNA|BTK_uc010nnk.2_RNA|BTK_uc010nnl.2_Missense_Mutation_p.E81K|BTK_uc010nnm.2_Missense_Mutation_p.E175K|BTK_uc010nnn.2_Missense_Mutation_p.E429K|BTK_uc010nno.2_Missense_Mutation_p.E639K	NM_000061	NP_000052	Q06187	BTK_HUMAN	Bruton agammaglobulinemia tyrosine kinase	605	Protein kinase.				calcium-mediated signaling|induction of apoptosis by extracellular signals|mesoderm development	cytosol|membrane raft|nucleus|plasma membrane	ATP binding|identical protein binding|metal ion binding|non-membrane spanning protein tyrosine kinase activity|phosphatidylinositol-3,4,5-trisphosphate binding			lung(3)|central_nervous_system(2)|ovary(1)	6						TCAGCAGTCTCACTGTTAGTA	0.433		NaN							Agammaglobulinemia_X-linked				0	0	0	0.01441	0	110	88									
PAK3	5063	broad.mit.edu	37	X	110395674	110395674	+	Missense_Mutation	SNP	C	C	T	rs139949467		TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chrX:110395674C>T	uc004epa.2	+	5	539	c.512C>T	c.(511-513)TCG>TTG	p.S171L	PAK3_uc010npt.1_Missense_Mutation_p.S156L|PAK3_uc010npu.1_Missense_Mutation_p.S156L|PAK3_uc004eoy.1_5'UTR|PAK3_uc004eoz.2_Missense_Mutation_p.S156L|PAK3_uc011mst.1_RNA|PAK3_uc010npv.1_Missense_Mutation_p.S192L|PAK3_uc010npw.1_Missense_Mutation_p.S177L	NM_001128173	NP_001121645	O75914	PAK3_HUMAN	p21-activated kinase 3 isoform d	171	Linker.				multicellular organismal development		ATP binding|metal ion binding|protein serine/threonine kinase activity|SH3 domain binding			lung(6)|ovary(3)|large_intestine(1)	10						GCCCATCCTTCGGTAAGTGAA	0.338		NaN								TSP Lung(19;0.15)			0	0	0	0.006122	0	17	57									
TKTL1	8277	broad.mit.edu	37	X	153524334	153524334	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chrX:153524334C>T	uc004fkg.2	+	1	308	c.122C>T	c.(121-123)TCC>TTC	p.S41F	TEX28_uc004fke.2_5'Flank|TEX28_uc004fkf.2_5'Flank|TEX28_uc010nut.1_5'Flank|TKTL1_uc011mzl.1_Missense_Mutation_p.S41F|TKTL1_uc011mzm.1_Missense_Mutation_p.S41F	NM_012253	NP_036385	P51854	TKTL1_HUMAN	transketolase-like 1 isoform a	41					glucose catabolic process|thiamine metabolic process	cytoplasm|nucleus	metal ion binding|transketolase activity			ovary(3)|skin(1)	4	all_cancers(53;5.05e-16)|all_epithelial(53;1.82e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					GCCACATGCTCCACGAGCTCC	0.622		NaN											0	0	0	0.00499	0	18	53									
PLXNA3	55558	broad.mit.edu	37	X	153697282	153697282	+	Silent	SNP	C	C	T			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chrX:153697282C>T	uc004flm.2	+	25	4577	c.4404C>T	c.(4402-4404)CTC>CTT	p.L1468L		NM_017514	NP_059984	P51805	PLXA3_HUMAN	plexin A3 precursor	1468	Cytoplasmic (Potential).				axon guidance	integral to membrane|intracellular|plasma membrane	transmembrane receptor activity			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	3	all_cancers(53;5.05e-16)|all_epithelial(53;1.87e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					AGGACAAGCTCATCCGTCAGC	0.612		NaN											0	0	0	0.004878	0	34	23									
USP9Y	8287	broad.mit.edu	37	Y	14832567	14832567	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chrY:14832567C>A	uc004fst.1	+	4	1087	c.142C>A	c.(142-144)CCT>ACT	p.P48T	USP9Y_uc010nwu.1_RNA	NM_004654	NP_004645	O00507	USP9Y_HUMAN	ubiquitin specific protease 9, Y-linked	48					BMP signaling pathway|protein deubiquitination|spermatogenesis|transforming growth factor beta receptor signaling pathway|ubiquitin-dependent protein catabolic process	cytoplasm	co-SMAD binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity				0						AGCAACTCCTCCTCCAGAGGA	0.403		NaN											1	0	6.36457e-07	0.003954	6.53519e-07	25	28									
TNFRSF25	8718	broad.mit.edu	37	1	6525566	6525567	+	Frame_Shift_Ins	INS	-	-	G			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:6525566_6525567insG	uc001ane.2	-	2	181_182	c.93_94insC	c.(91-96)CCCAGGfs	p.P31fs	TNFRSF25_uc001ana.2_Frame_Shift_Ins_p.P31fs|TNFRSF25_uc001anb.2_RNA|TNFRSF25_uc001anc.2_RNA|TNFRSF25_uc001and.2_5'UTR|TNFRSF25_uc009vlz.2_RNA|TNFRSF25_uc001anf.2_Frame_Shift_Ins_p.P31fs|TNFRSF25_uc001ang.2_Frame_Shift_Ins_p.P31fs|TNFRSF25_uc001anh.2_Frame_Shift_Ins_p.P31fs|TNFRSF25_uc001ani.1_Frame_Shift_Ins_p.P31fs	NM_003790	NP_003781	Q93038	TNR25_HUMAN	tumor necrosis factor receptor superfamily,	31_32	Extracellular (Potential).				apoptosis|induction of apoptosis by extracellular signals	cytosol|extracellular region|integral to plasma membrane	tumor necrosis factor receptor activity			central_nervous_system(2)|breast(1)	3	Ovarian(185;0.0386)|all_lung(157;0.154)	all_cancers(23;1.7e-35)|all_epithelial(116;2.78e-22)|all_lung(118;7.57e-07)|Lung NSC(185;4.26e-06)|Colorectal(325;4.47e-05)|all_hematologic(16;0.00014)|Breast(487;0.000688)|Renal(390;0.0007)|Acute lymphoblastic leukemia(12;0.00157)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0448)		Epithelial(90;4.58e-35)|GBM - Glioblastoma multiforme(13;3.06e-27)|Colorectal(212;6.01e-08)|COAD - Colon adenocarcinoma(227;1.3e-05)|Kidney(185;4.88e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000871)|BRCA - Breast invasive adenocarcinoma(365;0.00105)|STAD - Stomach adenocarcinoma(132;0.00158)|READ - Rectum adenocarcinoma(331;0.0419)		CAGTCACACCTGGGGCTACGAG	0.673		NaN											NaN	NaN	NaN	NaN	NaN	9	43	---	---							
ENO1	2023	broad.mit.edu	37	1	8927225	8927226	+	Frame_Shift_Ins	INS	-	-	GG	rs144538182	by1000genomes	TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:8927225_8927226insGG	uc001apj.1	-	6	545_546	c.394_395insCC	c.(394-396)CGCfs	p.R132fs	ENO1_uc001api.1_Frame_Shift_Ins_p.R36fs|ENO1_uc001apk.1_Frame_Shift_Ins_p.R77fs|ENO1_uc001apl.1_Frame_Shift_Ins_p.R132fs|ENO1_uc009vmi.1_Frame_Shift_Ins_p.R89fs|ENO1_uc009vmj.1_Frame_Shift_Ins_p.R132fs|ENO1_uc009vmk.1_Intron|ENO1_uc009vml.1_Frame_Shift_Ins_p.R132fs	NM_001428	NP_001419	P06733	ENOA_HUMAN	enolase 1	132	Required for repression of c-myc promoter activity.				gluconeogenesis|glycolysis|negative regulation of cell growth|negative regulation of transcription from RNA polymerase II promoter|response to virus	phosphopyruvate hydratase complex|plasma membrane|sarcomere	DNA binding|magnesium ion binding|phosphopyruvate hydratase activity|protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			ovary(2)|kidney(1)|central_nervous_system(1)	4	Ovarian(185;0.0661)|all_lung(157;0.127)	all_epithelial(116;2.54e-20)|all_lung(118;2.99e-06)|Lung NSC(185;6.25e-06)|Renal(390;0.000147)|Breast(348;0.00086)|Colorectal(325;0.00205)|Hepatocellular(190;0.00825)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;2.42e-07)|COAD - Colon adenocarcinoma(227;2.78e-05)|Kidney(185;0.000249)|KIRC - Kidney renal clear cell carcinoma(229;0.000911)|STAD - Stomach adenocarcinoma(132;0.00177)|BRCA - Breast invasive adenocarcinoma(304;0.00185)|READ - Rectum adenocarcinoma(331;0.0642)		AGCGATGTGGCGGTACAGGGGG	0.559		NaN											NaN	NaN	NaN	NaN	NaN	9	81	---	---							
TMCO2	127391	broad.mit.edu	37	1	40713708	40713709	+	Frame_Shift_Del	DEL	TC	TC	-			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:40713708_40713709delTC	uc001cfe.2	+	1	136_137	c.43_44delTC	c.(43-45)TCTfs	p.S15fs		NM_001008740	NP_001008740	Q7Z6W1	TMCO2_HUMAN	transmembrane and coiled-coil domains 2	15						integral to membrane				ovary(1)	1	Lung NSC(20;4.38e-06)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;6.3e-18)			CCTCTTAGAGTCTCTCTCTCTC	0.406		NaN											NaN	NaN	NaN	NaN	NaN	8	810	---	---							
ARHGEF11	9826	broad.mit.edu	37	1	156911698	156911698	+	Frame_Shift_Del	DEL	G	G	-			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:156911698delG	uc001fqo.2	-	33	4330	c.3290delC	c.(3289-3291)CCAfs	p.P1097fs	ARHGEF11_uc010phu.1_Frame_Shift_Del_p.P513fs|ARHGEF11_uc001fqn.2_Frame_Shift_Del_p.P1137fs	NM_014784	NP_055599	O15085	ARHGB_HUMAN	Rho guanine nucleotide exchange factor (GEF) 11	1097	Poly-Pro.				actin cytoskeleton organization|apoptosis|axon guidance|cellular component movement|cytokinesis|establishment of cell polarity|G-protein coupled receptor protein signaling pathway|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|positive regulation of transcription, DNA-dependent|regulation of cell growth|regulation of Rho protein signal transduction|Rho protein signal transduction|striated muscle contraction	cytosol|Golgi apparatus|plasma membrane	G-protein-coupled receptor binding|GTPase activator activity|Rho guanyl-nucleotide exchange factor activity|signal transducer activity			ovary(3)|skin(2)|pleura(1)|lung(1)|kidney(1)|pancreas(1)	9	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					CCGGGGACCTGGGGGTGGAGG	0.647		NaN											NaN	NaN	NaN	NaN	NaN	14	81	---	---							
TSKU	25987	broad.mit.edu	37	11	76507283	76507284	+	Frame_Shift_Ins	INS	-	-	C			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr11:76507283_76507284insC	uc001oxt.2	+	2	795_796	c.623_624insC	c.(622-624)CGCfs	p.R208fs		NM_015516	NP_056331	Q8WUA8	TSK_HUMAN	tsukushin precursor	208	LRR 7.					extracellular region					0	Ovarian(111;0.112)					TTGCCCCTGCGCTACCTGAGCC	0.673		NaN											NaN	NaN	NaN	NaN	NaN	43	127	---	---							
MBD6	114785	broad.mit.edu	37	12	57920933	57920934	+	Frame_Shift_Ins	INS	-	-	C			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr12:57920933_57920934insC	uc001soj.1	+	7	2229_2230	c.2005_2006insC	c.(2005-2007)GCCfs	p.A669fs	MBD6_uc001sok.1_Frame_Shift_Ins_p.A536fs|MBD6_uc001sol.1_RNA	NM_052897	NP_443129	Q96DN6	MBD6_HUMAN	methyl-CpG binding domain protein 6	669	Pro-rich.					chromosome|nucleus	chromatin binding|DNA binding			central_nervous_system(3)|ovary(1)	4						CCCACTTTCAGCCCCCCCTACC	0.639		NaN											NaN	NaN	NaN	NaN	NaN	10	38	---	---							
KEAP1	9817	broad.mit.edu	37	19	10599968	10599969	+	Frame_Shift_Ins	INS	-	-	CA			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr19:10599968_10599969insCA	uc002moq.1	-	5	1763_1764	c.1607_1608insTG	c.(1606-1608)CGCfs	p.R536fs	KEAP1_uc002mop.1_Intron|KEAP1_uc002mor.1_Frame_Shift_Ins_p.R536fs	NM_012289	NP_036421	Q14145	KEAP1_HUMAN	kelch-like ECH-associated protein 1	536	Kelch 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|midbody|nucleus	protein binding			lung(12)|breast(3)|ovary(1)|pancreas(1)	17			OV - Ovarian serous cystadenocarcinoma(20;2.71e-09)|Epithelial(33;2.32e-06)|all cancers(31;1.42e-05)			CCACATCGTAGCGCTCCACGCT	0.574		NaN											NaN	NaN	NaN	NaN	NaN	11	27	---	---							
ZNF513	130557	broad.mit.edu	37	2	27603057	27603058	+	Frame_Shift_Del	DEL	CA	CA	-			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr2:27603057_27603058delCA	uc002rkk.2	-	2	313_314	c.113_114delTG	c.(112-114)TTGfs	p.L38fs	ZNF513_uc002rkj.2_5'UTR	NM_144631	NP_653232	Q8N8E2	ZN513_HUMAN	zinc finger protein 513	38					regulation of transcription, DNA-dependent|response to stimulus|retina development in camera-type eye|transcription, DNA-dependent|visual perception	nucleus	transcription regulatory region DNA binding|zinc ion binding			ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GGCCTAGTAGCAAATCACTCTC	0.574		NaN											NaN	NaN	NaN	NaN	NaN	47	153	---	---							
GPR17	2840	broad.mit.edu	37	2	128408472	128408473	+	Frame_Shift_Ins	INS	-	-	T	rs17852981		TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr2:128408472_128408473insT	uc010yzn.1	+	4	858_859	c.247_248insT	c.(247-249)CTTfs	p.L83fs	LIMS2_uc002tow.2_5'Flank|LIMS2_uc002tox.2_Intron|LIMS2_uc010fmb.2_Intron|LIMS2_uc002toy.2_Intron|LIMS2_uc010yzm.1_Intron|LIMS2_uc002tpa.2_Intron|LIMS2_uc002toz.2_Intron|LIMS2_uc002tpb.2_Intron|GPR17_uc002tpc.2_Frame_Shift_Ins_p.L83fs|GPR17_uc010yzo.1_Frame_Shift_Ins_p.L55fs|GPR17_uc002tpd.2_Frame_Shift_Ins_p.L55fs	NM_001161415	NP_001154887	Q13304	GPR17_HUMAN	G protein-coupled receptor 17 isoform a	83	Helical; Name=1; (Potential).			L -> F (in Ref. 5; AAH31653).		integral to plasma membrane	chemokine receptor activity|purinergic nucleotide receptor activity, G-protein coupled				0	Colorectal(110;0.1)	Ovarian(717;0.15)		BRCA - Breast invasive adenocarcinoma(221;0.0677)		GGCTCTGTGGCTTTTCATCCGA	0.381		NaN											NaN	NaN	NaN	NaN	NaN	38	111	---	---							
LASS6	253782	broad.mit.edu	37	2	169571567	169571572	+	In_Frame_Del	DEL	ATATGT	ATATGT	-			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr2:169571567_169571572delATATGT	uc002ueb.1	+	7	790_795	c.666_671delATATGT	c.(664-672)TCATATGTC>TCC	p.YV223del	LASS6_uc002uec.1_In_Frame_Del_p.YV223del	NM_203463	NP_982288	Q6ZMG9	CERS6_HUMAN	longevity assurance homolog 6	223_224	Helical; (Potential).|TLC.					endoplasmic reticulum membrane|integral to membrane|nuclear membrane	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|sphingosine N-acyltransferase activity			skin(1)	1						TTACCTTTTCATATGTCAACAATATG	0.374		NaN											NaN	NaN	NaN	NaN	NaN	104	186	---	---							
SDPR	8436	broad.mit.edu	37	2	192701073	192701073	+	Frame_Shift_Del	DEL	C	C	-			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr2:192701073delC	uc002utb.2	-	2	1184	c.854delG	c.(853-855)GGAfs	p.G285fs		NM_004657	NP_004648	O95810	SDPR_HUMAN	serum deprivation response protein	285						caveola|cytosol	phosphatidylserine binding|protein binding			ovary(1)|pancreas(1)	2			OV - Ovarian serous cystadenocarcinoma(117;0.0647)		Phosphatidylserine(DB00144)	GGAGCTTTTTCCTGAGGATAT	0.458		NaN											NaN	NaN	NaN	NaN	NaN	130	291	---	---							
ITGA9	3680	broad.mit.edu	37	3	37695244	37695257	+	Frame_Shift_Del	DEL	GCAGACCTGCAGCT	GCAGACCTGCAGCT	-			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr3:37695244_37695257delGCAGACCTGCAGCT	uc003chd.2	+	17	1932_1945	c.1879_1892delGCAGACCTGCAGCT	c.(1879-1893)GCAGACCTGCAGCTTfs	p.A627fs		NM_002207	NP_002198	Q13797	ITA9_HUMAN	integrin, alpha 9 precursor	627_631	Extracellular (Potential).				axon guidance|cell adhesion|integrin-mediated signaling pathway	integrin complex	receptor activity			breast(3)|pancreas(1)|lung(1)|skin(1)	6				KIRC - Kidney renal clear cell carcinoma(284;0.165)|Kidney(284;0.197)		GGACTGTGCCGCAGACCTGCAGCTTCAGGGTAAA	0.505		NaN											NaN	NaN	NaN	NaN	NaN	33	125	---	---							
IMPG2	50939	broad.mit.edu	37	3	100964653	100964654	+	Frame_Shift_Ins	INS	-	-	A			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr3:100964653_100964654insA	uc003duq.1	-	12	1738_1739	c.1535_1536insT	c.(1534-1536)GTAfs	p.V512fs	IMPG2_uc011bhe.1_Frame_Shift_Ins_p.V375fs	NM_016247	NP_057331	Q9BZV3	IMPG2_HUMAN	interphotoreceptor matrix proteoglycan 2	512	Extracellular (Potential).				visual perception	integral to membrane|proteinaceous extracellular matrix	extracellular matrix structural constituent|heparin binding|hyaluronic acid binding|receptor activity			ovary(2)|haematopoietic_and_lymphoid_tissue(1)	3						CACCATCTTCTACCAAGTGAGA	0.436		NaN											NaN	NaN	NaN	NaN	NaN	73	155	---	---							
MORC1	27136	broad.mit.edu	37	3	108682419	108682419	+	Frame_Shift_Del	DEL	T	T	-			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr3:108682419delT	uc003dxl.2	-	27	2728	c.2641delA	c.(2641-2643)ATAfs	p.I881fs	MORC1_uc011bhn.1_Frame_Shift_Del_p.I860fs	NM_014429	NP_055244	Q86VD1	MORC1_HUMAN	MORC family CW-type zinc finger 1	881					cell differentiation|multicellular organismal development|spermatogenesis	nucleus	ATP binding|zinc ion binding			ovary(3)|skin(3)|breast(2)	8						TTCCTCTTTATTTTTTTTTCA	0.284		NaN											NaN	NaN	NaN	NaN	NaN	17	160	---	---							
RAD50	10111	broad.mit.edu	37	5	131915089	131915102	+	Frame_Shift_Del	DEL	CTGTGCTAAATAAT	CTGTGCTAAATAAT	-	rs138060491		TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr5:131915089_131915102delCTGTGCTAAATAAT	uc003kxi.2	+	4	833_846	c.446_459delCTGTGCTAAATAAT	c.(445-459)GCTGTGCTAAATAATfs	p.A149fs	RAD50_uc003kxg.1_Frame_Shift_Del_p.A50fs|RAD50_uc003kxh.2_Frame_Shift_Del_p.A10fs	NM_005732	NP_005723	Q92878	RAD50_HUMAN	RAD50 homolog isoform 1	149_153					DNA duplex unwinding|double-strand break repair via homologous recombination|positive regulation of kinase activity|positive regulation of protein autophosphorylation|reciprocal meiotic recombination|regulation of mitotic recombination|telomere maintenance via telomerase	Mre11 complex|nuclear chromosome, telomeric region|nucleoplasm	ATP binding|DNA binding|nuclease activity|protein binding, bridging|zinc ion binding			lung(2)|ovary(1)|skin(1)	4		all_cancers(142;0.0368)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			GTTTCCAAGGCTGTGCTAAATAATGTCATTTTCT	0.374		NaN						Homologous_recombination					NaN	NaN	NaN	NaN	NaN	19	78	---	---							
KDM6A	7403	broad.mit.edu	37	X	44894229	44894232	+	Splice_Site	DEL	AAGT	AAGT	-			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08			AAGT	-	AAGT	AAGT		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chrX:44894229_44894232delAAGT	uc004dge.3	+	7	994	c.619_splice	c.e7+1	p.I207_splice	KDM6A_uc010nhk.2_Splice_Site_p.I207_splice|KDM6A_uc011mkz.1_Splice_Site_p.I207_splice|KDM6A_uc011mla.1_Splice_Site_p.I207_splice|KDM6A_uc011mlb.1_Splice_Site_p.I207_splice|KDM6A_uc011mlc.1_Splice_Site	NM_021140	NP_066963	O15550	KDM6A_HUMAN	ubiquitously transcribed tetratricopeptide						histone H3-K4 methylation		metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	p.0(2)|p.?(1)		kidney(24)|haematopoietic_and_lymphoid_tissue(23)|oesophagus(11)|large_intestine(7)|lung(5)|breast(4)|central_nervous_system(3)|urinary_tract(3)|endometrium(2)|pancreas(2)	84						CCAATGCTGAAAGTAAGTATTATT	0.333		NaN	D|N|F|S		renal|oesophageal SCC|MM								NaN	NaN	NaN	NaN	NaN	66	56	---	---