Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	isArtifactMode	oxoGCut	pox	pox_cutoff	qox	t_alt_count	t_ref_count	validation_alt_allele	validation_tumor_sample							
H6PD	9563	broad.mit.edu	37	1	9324830	9324830	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr1:9324830C>T	uc001apt.2	+	5	2551	c.2278C>T	c.(2278-2280)CGG>TGG	p.R760W		NM_004285	NP_004276	O95479	G6PE_HUMAN	hexose-6-phosphate dehydrogenase precursor	760	6-phosphogluconolactonase.					endoplasmic reticulum lumen	6-phosphogluconolactonase activity|glucose 1-dehydrogenase|glucose-6-phosphate dehydrogenase activity|NADP binding				0	all_lung(157;0.23)	all_epithelial(116;1.28e-19)|all_lung(118;5.22e-06)|Lung NSC(185;1.98e-05)|Renal(390;0.000147)|Breast(348;0.00109)|Colorectal(325;0.00205)|Hepatocellular(190;0.00825)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;1.88e-07)|COAD - Colon adenocarcinoma(227;7.47e-05)|Kidney(185;0.000244)|KIRC - Kidney renal clear cell carcinoma(229;0.000905)|STAD - Stomach adenocarcinoma(132;0.00176)|BRCA - Breast invasive adenocarcinoma(304;0.00183)|READ - Rectum adenocarcinoma(331;0.0419)	NADH(DB00157)	GCTGGTGAGCCGGGTGGGCCA	0.637		NaN											0	0	0	0.010729	0	12	30									
ATP13A2	23400	broad.mit.edu	37	1	17313397	17313397	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr1:17313397C>G	uc001baa.2	-	27	3328	c.3138G>C	c.(3136-3138)GAG>GAC	p.E1046D	ATP13A2_uc001azz.1_Missense_Mutation_p.E193D|ATP13A2_uc001bab.2_Missense_Mutation_p.E1041D|ATP13A2_uc001bac.2_Missense_Mutation_p.E1002D	NM_022089	NP_071372	Q9NQ11	AT132_HUMAN	ATPase type 13A2 isoform 1	1046	Extracellular (Potential).				ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			skin(2)|ovary(1)|central_nervous_system(1)	4		Colorectal(325;0.000147)|Breast(348;0.00104)|Renal(390;0.00145)|Lung NSC(340;0.00566)|all_lung(284;0.00797)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0646)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00462)|COAD - Colon adenocarcinoma(227;1.11e-05)|BRCA - Breast invasive adenocarcinoma(304;1.99e-05)|Kidney(64;0.000171)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00645)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.182)		CCACGGTGTTCTCGTAGTTGG	0.627		NaN											0	0	0	0.00308	0	7	27									
HSPG2	3339	broad.mit.edu	37	1	22176612	22176612	+	Silent	SNP	C	C	G			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr1:22176612C>G	uc001bfj.2	-	57	7408	c.7368G>C	c.(7366-7368)CTG>CTC	p.L2456L	HSPG2_uc009vqd.2_Silent_p.L2457L	NM_005529	NP_005520	P98160	PGBM_HUMAN	heparan sulfate proteoglycan 2 precursor	2456	Ig-like C2-type 10.				angiogenesis|cell adhesion|lipid metabolic process|lipoprotein metabolic process	basement membrane|extracellular space|plasma membrane	protein C-terminus binding			ovary(5)|large_intestine(2)|central_nervous_system(1)|skin(1)	9		Colorectal(325;3.46e-05)|all_lung(284;7.93e-05)|Lung NSC(340;8.71e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0498)|OV - Ovarian serous cystadenocarcinoma(117;1.14e-26)|Colorectal(126;4.18e-07)|COAD - Colon adenocarcinoma(152;1.82e-05)|GBM - Glioblastoma multiforme(114;3.13e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000756)|STAD - Stomach adenocarcinoma(196;0.00656)|KIRC - Kidney renal clear cell carcinoma(1967;0.00942)|READ - Rectum adenocarcinoma(331;0.0721)|Lung(427;0.223)	Becaplermin(DB00102)|Palifermin(DB00039)	CGAGGCAGTTCAGGTCCAGGG	0.662		NaN											0	0	0	0.00623	0	38	86									
KDM1A	23028	broad.mit.edu	37	1	23382467	23382467	+	Nonsense_Mutation	SNP	C	C	G			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr1:23382467C>G	uc001bgi.2	+	6	1015	c.866C>G	c.(865-867)TCA>TGA	p.S289*	KDM1A_uc001bgj.2_Nonsense_Mutation_p.S309*	NM_015013	NP_055828	O60341	KDM1A_HUMAN	lysine-specific histone demethylase 1 isoform b	289	FAD (Potential).	FAD.			blood coagulation|muscle cell development|negative regulation of apoptosis|negative regulation of DNA damage response, signal transduction by p53 class mediator|negative regulation of protein binding|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nuclear chromatin	androgen receptor binding|chromatin binding|enzyme binding|flavin adenine dinucleotide binding|histone demethylase activity (H3-dimethyl-K4 specific)|histone demethylase activity (H3-K9 specific)|ligand-dependent nuclear receptor transcription coactivator activity|MyoD binding|oxidoreductase activity|p53 binding|transcription regulatory region DNA binding			ovary(1)|lung(1)	2						TCTGGGGTCTCAGGCTTGGCA	0.358		NaN											0	0	0	0.01441	0	44	169									
MYOM3	127294	broad.mit.edu	37	1	24392393	24392393	+	Silent	SNP	G	G	A			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr1:24392393G>A	uc001bin.3	-	29	3685	c.3522C>T	c.(3520-3522)CTC>CTT	p.L1174L	MYOM3_uc001bil.3_Silent_p.L67L|MYOM3_uc001bim.3_Silent_p.L831L|MYOM3_uc001bio.2_Silent_p.L1174L	NM_152372	NP_689585	Q5VTT5	MYOM3_HUMAN	myomesin family, member 3	1174	Ig-like C2-type 3.									skin(2)|ovary(1)	3		Colorectal(325;3.55e-05)|Renal(390;0.000703)|Lung NSC(340;0.001)|all_lung(284;0.0014)|Ovarian(437;0.00351)|Breast(348;0.0126)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;5.31e-24)|Colorectal(126;7.52e-08)|COAD - Colon adenocarcinoma(152;4.01e-06)|GBM - Glioblastoma multiforme(114;4.36e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00108)|KIRC - Kidney renal clear cell carcinoma(1967;0.00404)|STAD - Stomach adenocarcinoma(196;0.00966)|READ - Rectum adenocarcinoma(331;0.0678)|Lung(427;0.153)		CTTCAATGCAGAGAAGTCCCG	0.562		NaN											0	0	0	0.01441	0	55	138									
ARID1A	8289	broad.mit.edu	37	1	27058057	27058057	+	Nonsense_Mutation	SNP	C	C	T			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr1:27058057C>T	uc001bmv.1	+	3	2138	c.1765C>T	c.(1765-1767)CAA>TAA	p.Q589*	ARID1A_uc001bmt.1_Nonsense_Mutation_p.Q589*|ARID1A_uc001bmu.1_Nonsense_Mutation_p.Q589*|ARID1A_uc001bmw.1_Nonsense_Mutation_p.Q206*	NM_006015	NP_006006	O14497	ARI1A_HUMAN	AT rich interactive domain 1A isoform a	589					androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding			ovary(124)|pancreas(5)|central_nervous_system(3)|endometrium(3)|kidney(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	142		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		GCAGTCCCAGCAAACTGCCTA	0.607		NaN	Mis|N|F|S|D		clear cell ovarian carcinoma|RCC								0	0	0	0.01441	0	81	91									
MACF1	23499	broad.mit.edu	37	1	39888185	39888185	+	Missense_Mutation	SNP	G	G	A	rs148666575	byFrequency	TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr1:39888185G>A	uc010oiu.1	+	23	11407	c.11276G>A	c.(11275-11277)CGA>CAA	p.R3759Q	MACF1_uc010ois.1_Missense_Mutation_p.R3257Q|MACF1_uc001cda.1_Missense_Mutation_p.R3144Q|MACF1_uc001cdc.1_Missense_Mutation_p.R2323Q	NM_033044	NP_149033	Q9UPN3	MACF1_HUMAN	microfilament and actin filament cross-linker	5324	Spectrin 6.				cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			ovary(8)|breast(3)|central_nervous_system(3)|skin(2)	16	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			ATCAATGCTCGATGGAATACA	0.428		NaN											0	0	0	0.014323	0	21	50									
MACF1	23499	broad.mit.edu	37	1	39889764	39889764	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr1:39889764G>C	uc010oiu.1	+	25	11665	c.11534G>C	c.(11533-11535)AGA>ACA	p.R3845T	MACF1_uc010ois.1_Missense_Mutation_p.R3343T|MACF1_uc001cda.1_Missense_Mutation_p.R3230T|MACF1_uc001cdc.1_Missense_Mutation_p.R2409T	NM_033044	NP_149033	Q9UPN3	MACF1_HUMAN	microfilament and actin filament cross-linker	5410	Spectrin 7.				cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			ovary(8)|breast(3)|central_nervous_system(3)|skin(2)	16	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			GAAGGAGGCAGAATAGCCCAG	0.473		NaN											0	0	0	0.004007	0	15	63									
CLDN19	149461	broad.mit.edu	37	1	43205572	43205572	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr1:43205572C>T	uc001cht.1	-	1	354	c.163G>A	c.(163-165)GCC>ACC	p.A55T	CLDN19_uc001chu.2_Missense_Mutation_p.A55T|CLDN19_uc010ojv.1_Missense_Mutation_p.A55T	NM_148960	NP_683763	Q8N6F1	CLD19_HUMAN	claudin 19 isoform a	55	Extracellular (Potential).				calcium-independent cell-cell adhesion|response to stimulus|visual perception	basolateral plasma membrane|integral to membrane|tight junction	identical protein binding				0	Ovarian(52;0.00744)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				CTCTGGGAGGCGCAGGACATC	0.647		NaN											0	0	0	0.009096	0	4	16									
ATP6V0B	533	broad.mit.edu	37	1	44441505	44441505	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr1:44441505G>T	uc001cld.2	+	2	212	c.101G>T	c.(100-102)CGC>CTC	p.R34L	ATP6V0B_uc001clc.2_Missense_Mutation_p.R34L|ATP6V0B_uc001cle.2_Intron|ATP6V0B_uc001clf.2_5'UTR	NM_004047	NP_004038	Q99437	VATO_HUMAN	ATPase, H+ transporting, lysosomal 21kDa, V0	34	Cytoplasmic (Potential).				ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|insulin receptor signaling pathway|transferrin transport	endosome membrane|integral to membrane|proton-transporting V-type ATPase, V0 domain|vacuolar membrane	hydrogen ion transmembrane transporter activity			breast(1)	1	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0511)				TTGGGCTTCCGCTTTGATGTG	0.537		NaN											1	0	1.68136e-41	0.01441	1.90984e-41	77	203									
NRD1	4898	broad.mit.edu	37	1	52305975	52305975	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr1:52305975C>T	uc001ctc.3	-	2	875	c.553G>A	c.(553-555)GAT>AAT	p.D185N	NRD1_uc009vzb.2_5'UTR|NRD1_uc001ctd.3_Missense_Mutation_p.D185N|NRD1_uc001cte.2_Missense_Mutation_p.D53N|NRD1_uc001ctf.2_Missense_Mutation_p.D185N|NRD1_uc010ong.1_RNA|NRD1_uc009vzc.1_Missense_Mutation_p.D53N|NRD1_uc001ctg.1_5'Flank	NM_002525	NP_002516	O43847	NRDC_HUMAN	nardilysin isoform a	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					cell migration|cell proliferation|neuromuscular junction development|positive regulation of membrane protein ectodomain proteolysis|proteolysis|regulation of endopeptidase activity	cell surface|cytosol	epidermal growth factor binding|metalloendopeptidase activity|zinc ion binding				0						gtatcaagatcatcatcatgt	0.169		NaN											0	0	0	0.006122	0	18	42									
LEPR	3953	broad.mit.edu	37	1	66064359	66064359	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr1:66064359C>T	uc001dci.2	+	8	1068	c.866C>T	c.(865-867)TCA>TTA	p.S289L	LEPR_uc001dcg.2_Missense_Mutation_p.S289L|LEPR_uc001dch.2_Missense_Mutation_p.S289L|LEPR_uc009waq.2_Intron|LEPR_uc001dcj.2_Missense_Mutation_p.S289L|LEPR_uc001dck.2_Missense_Mutation_p.S289L	NM_002303	NP_002294	P48357	LEPR_HUMAN	leptin receptor isoform 1	289	Extracellular (Potential).|Fibronectin type-III 1.				energy reserve metabolic process|multicellular organismal development	extracellular region|integral to membrane|plasma membrane	cytokine receptor activity			skin(1)	1				OV - Ovarian serous cystadenocarcinoma(397;0.00722)|KIRC - Kidney renal clear cell carcinoma(1967;0.094)		AAGATTGTCTCAGCTACATCC	0.333		NaN											0	0	0	0.010504	0	16	89									
LRRC8D	55144	broad.mit.edu	37	1	90400469	90400469	+	Silent	SNP	A	A	G			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr1:90400469A>G	uc001dnm.2	+	3	2267	c.1842A>G	c.(1840-1842)ACA>ACG	p.T614T	LRRC8D_uc001dnn.2_Silent_p.T614T	NM_001134479	NP_001127951	Q7L1W4	LRC8D_HUMAN	leucine rich repeat containing 8 family, member	614	LRR 5.					integral to membrane	protein binding			ovary(2)	2		all_lung(203;0.0894)|Lung NSC(277;0.227)		all cancers(265;0.0109)|Epithelial(280;0.0427)		CACATCTTACAAAGTTAGTCA	0.438		NaN											0	0	0	0.01441	0	44	99									
DNTTIP2	30836	broad.mit.edu	37	1	94343392	94343392	+	Silent	SNP	C	C	T			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr1:94343392C>T	uc001dqf.2	-	2	137	c.99G>A	c.(97-99)GCG>GCA	p.A33A	DNTTIP2_uc010otm.1_RNA|DNTTIP2_uc009wdo.1_Intron	NM_014597	NP_055412	Q5QJE6	TDIF2_HUMAN	deoxynucleotidyltransferase, terminal,	33					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus					0		all_lung(203;0.0111)|Lung NSC(277;0.0347)		all cancers(265;0.00679)|GBM - Glioblastoma multiforme(16;0.0278)|Epithelial(280;0.128)		TTTCTGGATGCGCTTGAATCC	0.443		NaN											0	0	0	0.017118	0	35	27									
VTCN1	79679	broad.mit.edu	37	1	117699368	117699368	+	Silent	SNP	C	C	A	rs115383914	byFrequency	TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr1:117699368C>A	uc001ehb.2	-	3	345	c.273G>T	c.(271-273)TCG>TCT	p.S91S	VTCN1_uc001ehc.2_5'UTR|VTCN1_uc009whf.1_Intron	NM_024626	NP_078902	Q7Z7D3	VTCN1_HUMAN	V-set domain containing T cell activation	91	Ig-like V-type 1.|Extracellular (Potential).					integral to membrane|plasma membrane					0	Lung SC(450;0.225)	all_cancers(81;6.05e-06)|all_epithelial(167;5.59e-07)|all_lung(203;2.85e-06)|Lung NSC(69;2e-05)		Lung(183;0.0664)|LUSC - Lung squamous cell carcinoma(189;0.214)|Colorectal(144;0.23)		CATCCTGCTCCGACAGCTCAT	0.458		NaN											1	0	3.99451e-17	0.009535	4.29772e-17	32	94									
PDE4DIP	9659	broad.mit.edu	37	1	144871840	144871840	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr1:144871840G>C	uc001elw.3	-	32	5413	c.5122C>G	c.(5122-5124)CAG>GAG	p.Q1708E	NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|PDE4DIP_uc001elk.1_Intron|PDE4DIP_uc001ell.1_Intron|PDE4DIP_uc001elm.3_Intron|PDE4DIP_uc001eln.3_Intron|PDE4DIP_uc001elo.2_Intron|PDE4DIP_uc001elx.3_Intron|PDE4DIP_uc001elv.3_Missense_Mutation_p.Q715E	NM_014644	NP_055459	Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein isoform	1708					cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			ovary(4)|haematopoietic_and_lymphoid_tissue(1)	5				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		AATGGTGCCTGAGGAAGGCTA	0.507		NaN	T	PDGFRB	MPD								0	0	0	0.001984	0	7	168									
PDE4DIP	9659	broad.mit.edu	37	1	144918839	144918839	+	Silent	SNP	C	C	T			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr1:144918839C>T	uc001elw.3	-	10	1638	c.1347G>A	c.(1345-1347)TTG>TTA	p.L449L	NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|PDE4DIP_uc001elk.1_Intron|PDE4DIP_uc001ell.1_Intron|PDE4DIP_uc001elm.3_Intron|PDE4DIP_uc001eln.3_Intron|PDE4DIP_uc001elo.2_Intron|PDE4DIP_uc001elx.3_Silent_p.L515L|PDE4DIP_uc001emc.1_Silent_p.L449L|PDE4DIP_uc001emd.1_Silent_p.L449L|PDE4DIP_uc001emb.1_Silent_p.L612L|PDE4DIP_uc001eme.1_5'UTR|PDE4DIP_uc001emf.1_Silent_p.L236L	NM_014644	NP_055459	Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein isoform	449	Potential.				cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			ovary(4)|haematopoietic_and_lymphoid_tissue(1)	5				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		TCACCTGAAGCAACTGCTCCT	0.403		NaN	T	PDGFRB	MPD								0	0	0	0.01441	0	181	732									
HORMAD1	84072	broad.mit.edu	37	1	150675844	150675844	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr1:150675844G>T	uc001evk.1	-	13	1080	c.974C>A	c.(973-975)TCT>TAT	p.S325Y	HORMAD1_uc001evl.1_Missense_Mutation_p.S318Y|HORMAD1_uc001evm.1_Missense_Mutation_p.S245Y	NM_032132	NP_115508	Q86X24	HORM1_HUMAN	HORMA domain containing 1	325					blastocyst development|cell differentiation|meiotic DNA double-strand break formation|meiotic recombination checkpoint|meiotic sister chromatid cohesion|mitosis|oogenesis|regulation of homologous chromosome segregation|spermatogenesis|synaptonemal complex assembly	chromosome|nucleus				ovary(2)|central_nervous_system(1)	3	all_cancers(9;3.23e-52)|all_epithelial(9;4.68e-43)|all_lung(15;5.74e-35)|Lung NSC(24;2.09e-31)|Breast(34;0.0009)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Melanoma(130;0.128)|Colorectal(459;0.171)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0241)|Epithelial(6;2.32e-23)|all cancers(9;5.21e-23)|OV - Ovarian serous cystadenocarcinoma(6;6.72e-15)|BRCA - Breast invasive adenocarcinoma(12;0.000479)|LUSC - Lung squamous cell carcinoma(543;0.171)			ATCAAGTTCAGATGTTTTATT	0.274		NaN											1	0	3.09899e-07	0.004482	3.19705e-07	7	45									
PIP5K1A	8394	broad.mit.edu	37	1	151205031	151205031	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr1:151205031C>T	uc001exj.2	+	7	943	c.491C>T	c.(490-492)TCC>TTC	p.S164F	PIP5K1A_uc001exi.2_Missense_Mutation_p.S151F|PIP5K1A_uc010pcu.1_Missense_Mutation_p.S152F|PIP5K1A_uc001exk.2_Missense_Mutation_p.S151F|PIP5K1A_uc010pcv.1_5'Flank	NM_001135638	NP_001129110	Q99755	PI51A_HUMAN	phosphatidylinositol-4-phosphate 5-kinase, type	164	PIPK.				phospholipid biosynthetic process|signal transduction	endomembrane system|Golgi stack|lamellipodium|nuclear speck	1-phosphatidylinositol-4-phosphate 5-kinase activity|ATP binding|kinase binding			ovary(1)|central_nervous_system(1)|skin(1)	3	Lung SC(34;0.00471)|Ovarian(49;0.0147)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.181)			CCCCAGTATTCCCTCTGCAGT	0.423		NaN											0	0	0	0.016522	0	13	61									
PIP5K1A	8394	broad.mit.edu	37	1	151205035	151205035	+	Silent	SNP	C	C	T			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr1:151205035C>T	uc001exj.2	+	7	947	c.495C>T	c.(493-495)CTC>CTT	p.L165L	PIP5K1A_uc001exi.2_Silent_p.L152L|PIP5K1A_uc010pcu.1_Silent_p.L153L|PIP5K1A_uc001exk.2_Silent_p.L152L|PIP5K1A_uc010pcv.1_5'Flank	NM_001135638	NP_001129110	Q99755	PI51A_HUMAN	phosphatidylinositol-4-phosphate 5-kinase, type	165	PIPK.				phospholipid biosynthetic process|signal transduction	endomembrane system|Golgi stack|lamellipodium|nuclear speck	1-phosphatidylinositol-4-phosphate 5-kinase activity|ATP binding|kinase binding			ovary(1)|central_nervous_system(1)|skin(1)	3	Lung SC(34;0.00471)|Ovarian(49;0.0147)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.181)			AGTATTCCCTCTGCAGTGAGC	0.428		NaN											0	0	0	0.016522	0	12	57									
PIP5K1A	8394	broad.mit.edu	37	1	151205059	151205059	+	Silent	SNP	C	C	T			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr1:151205059C>T	uc001exj.2	+	7	971	c.519C>T	c.(517-519)CTC>CTT	p.L173L	PIP5K1A_uc001exi.2_Silent_p.L160L|PIP5K1A_uc010pcu.1_Silent_p.L161L|PIP5K1A_uc001exk.2_Silent_p.L160L|PIP5K1A_uc010pcv.1_5'Flank	NM_001135638	NP_001129110	Q99755	PI51A_HUMAN	phosphatidylinositol-4-phosphate 5-kinase, type	173	PIPK.				phospholipid biosynthetic process|signal transduction	endomembrane system|Golgi stack|lamellipodium|nuclear speck	1-phosphatidylinositol-4-phosphate 5-kinase activity|ATP binding|kinase binding			ovary(1)|central_nervous_system(1)|skin(1)	3	Lung SC(34;0.00471)|Ovarian(49;0.0147)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.181)			TGATTGAACTCTGTAGCTCTG	0.458		NaN											0	0	0	0.012213	0	21	65									
PIP5K1A	8394	broad.mit.edu	37	1	151205113	151205113	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr1:151205113C>G	uc001exj.2	+	7	1025	c.573C>G	c.(571-573)TTC>TTG	p.F191L	PIP5K1A_uc001exi.2_Missense_Mutation_p.F178L|PIP5K1A_uc010pcu.1_Missense_Mutation_p.F179L|PIP5K1A_uc001exk.2_Missense_Mutation_p.F178L|PIP5K1A_uc010pcv.1_5'Flank	NM_001135638	NP_001129110	Q99755	PI51A_HUMAN	phosphatidylinositol-4-phosphate 5-kinase, type	191	PIPK.				phospholipid biosynthetic process|signal transduction	endomembrane system|Golgi stack|lamellipodium|nuclear speck	1-phosphatidylinositol-4-phosphate 5-kinase activity|ATP binding|kinase binding			ovary(1)|central_nervous_system(1)|skin(1)	3	Lung SC(34;0.00471)|Ovarian(49;0.0147)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.181)			ACGATGAGTTCATTATTAAGA	0.488		NaN											0	0	0	0.00623	0	37	70									
FLG	2312	broad.mit.edu	37	1	152282887	152282887	+	Missense_Mutation	SNP	T	T	C			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr1:152282887T>C	uc001ezu.1	-	3	4511	c.4475A>G	c.(4474-4476)CAC>CGC	p.H1492R		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	1492	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TGACCCCGGGTGTCCACGAAT	0.587		NaN							Ichthyosis				0	0	0	0.01441	0	119	737									
CD1C	911	broad.mit.edu	37	1	158263070	158263070	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr1:158263070G>T	uc001fru.2	+	5	1250	c.958G>T	c.(958-960)GTG>TTG	p.V320L	CD1C_uc001frv.2_Intron	NM_001765	NP_001756	P29017	CD1C_HUMAN	CD1C antigen precursor	320	Helical; (Potential).				antigen processing and presentation|T cell activation involved in immune response	endosome membrane|integral to plasma membrane	endogenous lipid antigen binding|exogenous lipid antigen binding|glycolipid binding|lipopeptide binding			ovary(2)|skin(1)|pancreas(1)	4	all_hematologic(112;0.0378)					AATAGTCCTTGTGTTATGGTT	0.393		NaN											1	0	1.69816e-31	0.01441	1.9024e-31	78	736									
NCSTN	23385	broad.mit.edu	37	1	160326942	160326942	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr1:160326942G>C	uc001fvx.2	+	16	2030	c.1906G>C	c.(1906-1908)GAA>CAA	p.E636Q	NCSTN_uc001fvy.2_Missense_Mutation_p.E616Q|NCSTN_uc010pjf.1_Missense_Mutation_p.E498Q|NCSTN_uc001fvz.2_Missense_Mutation_p.E416Q|NCSTN_uc010pjg.1_Missense_Mutation_p.E378Q	NM_015331	NP_056146	Q92542	NICA_HUMAN	nicastrin precursor	636	Extracellular (Potential).				amyloid precursor protein catabolic process|apoptosis|induction of apoptosis by extracellular signals|membrane protein ectodomain proteolysis|membrane protein intracellular domain proteolysis|nerve growth factor receptor signaling pathway|Notch receptor processing|Notch signaling pathway|positive regulation of catalytic activity|protein processing	endoplasmic reticulum|Golgi apparatus|integral to plasma membrane|melanosome	protein binding			ovary(1)|lung(1)	2	all_cancers(52;8.15e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			TCCTGCCTTTGAACTGAGTCA	0.537		NaN											0	0	0	0.015359	0	32	375									
RGS4	5999	broad.mit.edu	37	1	163044271	163044271	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr1:163044271C>G	uc009wuy.2	+	5	1050	c.539C>G	c.(538-540)CCG>CGG	p.P180R	RGS4_uc001gcl.3_Missense_Mutation_p.P277R|RGS4_uc009wuz.2_3'UTR|RGS4_uc009wva.2_Missense_Mutation_p.P162R	NM_005613	NP_005604	P49798	RGS4_HUMAN	regulator of G-protein signaling 4 isoform 2	180					inactivation of MAPK activity|regulation of G-protein coupled receptor protein signaling pathway	plasma membrane	calmodulin binding|GTPase activator activity|signal transducer activity			ovary(2)|central_nervous_system(1)	3						TTGGTCAACCCGTCCAGCTGT	0.517		NaN											0	0	0	0.01441	0	56	436									
DCAF6	55827	broad.mit.edu	37	1	168007717	168007717	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr1:168007717C>T	uc001gew.2	+	11	1729	c.1487C>T	c.(1486-1488)ACA>ATA	p.T496I	DCAF6_uc001gev.2_Missense_Mutation_p.T516I|DCAF6_uc001gex.2_Missense_Mutation_p.T573I|DCAF6_uc010plk.1_Missense_Mutation_p.T542I|DCAF6_uc001gey.2_Missense_Mutation_p.T369I	NM_001017977	NP_001017977	Q58WW2	DCAF6_HUMAN	IQ motif and WD repeats 1 isoform b	496					positive regulation of transcription from RNA polymerase II promoter	CUL4 RING ubiquitin ligase complex|nucleus	ligand-dependent nuclear receptor transcription coactivator activity			ovary(1)|central_nervous_system(1)|skin(1)	3						CTGAACTTTACAGATGAATGG	0.333		NaN											0	0	0	0.010818	0	30	142									
FAM20B	9917	broad.mit.edu	37	1	179019501	179019501	+	Splice_Site	SNP	G	G	A			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr1:179019501G>A	uc001gmc.2	+	3	757	c.464_splice	c.e3+1	p.R155_splice		NM_014864	NP_055679	O75063	XYLK_HUMAN	hypothetical protein LOC9917 precursor							Golgi membrane|integral to membrane	ATP binding|kinase activity|phosphotransferase activity, alcohol group as acceptor			ovary(3)	3						ACTTGGACAGGTGCGTATGAT	0.443		NaN											0	0	0	0.01441	0	62	123									
RGS18	64407	broad.mit.edu	37	1	192127775	192127775	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr1:192127775C>T	uc001gsg.2	+	1	184	c.8C>T	c.(7-9)ACA>ATA	p.T3I		NM_130782	NP_570138	Q9NS28	RGS18_HUMAN	regulator of G-protein signalling 18	3					negative regulation of signal transduction	cytoplasm|plasma membrane	GTPase activator activity|signal transducer activity			ovary(3)	3						AAGATGGAAACAACATTGCTT	0.264		NaN											0	0	0	0.003163	0	16	45									
KIF14	9928	broad.mit.edu	37	1	200587160	200587160	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr1:200587160C>G	uc010ppk.1	-	2	1131	c.692G>C	c.(691-693)AGA>ACA	p.R231T	KIF14_uc010ppj.1_5'UTR	NM_014875	NP_055690	Q15058	KIF14_HUMAN	kinesin family member 14	231	Required for PRC1-binding.				microtubule-based movement	cytoplasm|microtubule|nucleus|spindle	ATP binding|microtubule motor activity|protein binding			breast(3)|ovary(2)|skin(2)	7						GTGTCCTGATCTAACAACTTC	0.408		NaN											0	0	0	0.01441	0	379	65									
CDC42BPA	8476	broad.mit.edu	37	1	227204728	227204728	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr1:227204728C>G	uc001hqr.2	-	32	5477	c.4534G>C	c.(4534-4536)GAA>CAA	p.E1512Q	CDC42BPA_uc001hqq.2_Missense_Mutation_p.E811Q|CDC42BPA_uc001hqs.2_Missense_Mutation_p.E1431Q|CDC42BPA_uc009xes.2_Missense_Mutation_p.E1484Q|CDC42BPA_uc010pvs.1_Missense_Mutation_p.E1492Q|CDC42BPA_uc001hqp.2_Missense_Mutation_p.E668Q|CDC42BPA_uc001hqt.2_Missense_Mutation_p.E390Q	NM_003607	NP_003598	Q5VT25	MRCKA_HUMAN	CDC42-binding protein kinase alpha isoform B	1525					actin cytoskeleton reorganization|intracellular signal transduction	cell leading edge|cell-cell junction|cytoplasm	ATP binding|identical protein binding|magnesium ion binding|protein serine/threonine kinase activity|small GTPase regulator activity			lung(6)|breast(2)|stomach(1)|ovary(1)|pancreas(1)	11		all_cancers(173;0.156)|Prostate(94;0.0792)				TCTGATGTTTCAGGTACTACC	0.363		NaN											0	0	0	0.01441	0	60	103									
HEATR1	55127	broad.mit.edu	37	1	236729993	236729993	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr1:236729993C>T	uc001hyd.1	-	30	4386	c.4261G>A	c.(4261-4263)GAA>AAA	p.E1421K	HEATR1_uc009xgh.1_Missense_Mutation_p.E583K	NM_018072	NP_060542	Q9H583	HEAT1_HUMAN	protein BAP28	1421					rRNA processing	nucleolus|ribonucleoprotein complex	protein binding			ovary(2)|skin(1)	3	Ovarian(103;0.0634)|Breast(184;0.133)	all_cancers(173;0.0255)|Prostate(94;0.175)	OV - Ovarian serous cystadenocarcinoma(106;0.00117)			ACATACTGTTCAAAAAGCAAG	0.488		NaN											0	0	0	0.009535	0	28	36									
OR1C1	26188	broad.mit.edu	37	1	247921243	247921243	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr1:247921243C>A	uc010pza.1	-	1	466	c.466G>T	c.(466-468)GCC>TCC	p.A156S		NM_012353	NP_036485	Q15619	OR1C1_HUMAN	olfactory receptor, family 1, subfamily C,	156	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	all_cancers(71;4.34e-05)|all_epithelial(71;1.13e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0786)|Lung NSC(105;0.0858)	all_cancers(173;0.0247)	OV - Ovarian serous cystadenocarcinoma(106;0.0168)			TGCAGGAGGGCGTGGAGGTAA	0.498		NaN											1	0	1.49673e-21	0.00623	1.64288e-21	41	7									
MYO3A	53904	broad.mit.edu	37	10	26377316	26377316	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr10:26377316G>T	uc001isn.2	+	15	1904	c.1544G>T	c.(1543-1545)CGA>CTA	p.R515L	MYO3A_uc009xko.1_Missense_Mutation_p.R515L|MYO3A_uc009xkp.1_RNA|MYO3A_uc009xkq.1_Missense_Mutation_p.R515L	NM_017433	NP_059129	Q8NEV4	MYO3A_HUMAN	myosin IIIA	515	Myosin head-like.				protein autophosphorylation|response to stimulus|sensory perception of sound|visual perception	cytoplasm|filamentous actin|filopodium|myosin complex	actin binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|plus-end directed microfilament motor activity|protein serine/threonine kinase activity			ovary(6)|stomach(3)|lung(3)|central_nervous_system(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	18						GAAAAATCCCGAGTTATCCAC	0.348		NaN											1	0	8.83742e-36	0.01441	9.96885e-36	73	47									
BMS1	9790	broad.mit.edu	37	10	43292463	43292463	+	Missense_Mutation	SNP	G	G	A	rs145513181		TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr10:43292463G>A	uc001jaj.2	+	10	2129	c.1771G>A	c.(1771-1773)GAA>AAA	p.E591K		NM_014753	NP_055568	Q14692	BMS1_HUMAN	BMS1-like, ribosome assembly protein	591					ribosome assembly	nucleolus	ATP binding|GTP binding|GTPase activity			ovary(2)|upper_aerodigestive_tract(1)	3						GTTTGCATCTGAAGATGAATC	0.448		NaN											0	0	0	0.021523	0	23	82									
SLC18A3	6572	broad.mit.edu	37	10	50819136	50819136	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr10:50819136C>T	uc001jhw.2	+	1	790	c.350C>T	c.(349-351)ACG>ATG	p.T117M	CHAT_uc001jhv.1_Intron|CHAT_uc001jhx.1_5'Flank|CHAT_uc001jhy.1_5'Flank|CHAT_uc001jia.2_5'Flank|CHAT_uc001jhz.2_5'Flank	NM_003055	NP_003046	Q16572	VACHT_HUMAN	vesicular acetylcholine transporter	117	Lumenal, vesicle (Potential).				neurotransmitter secretion	clathrin sculpted acetylcholine transport vesicle membrane|integral to plasma membrane|membrane fraction	acetylcholine transmembrane transporter activity			ovary(2)	2						CGCTACCCTACGGAGAGCGAA	0.657		NaN											0	0	0	0.00632	0	25	47									
ADAMTS14	140766	broad.mit.edu	37	10	72511899	72511899	+	Missense_Mutation	SNP	T	T	G			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr10:72511899T>G	uc001jrh.2	+	18	2645	c.2645T>G	c.(2644-2646)ATG>AGG	p.M882R	ADAMTS14_uc001jrg.2_Missense_Mutation_p.M885R	NM_080722	NP_542453	Q8WXS8	ATS14_HUMAN	ADAM metallopeptidase with thrombospondin type 1	882	TSP type-1 2.				collagen catabolic process|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(5)|upper_aerodigestive_tract(1)	6						GACCACCACATGGTGCAGCGA	0.657		NaN											0	0	0	0.001984	0	6	15									
CDH23	64072	broad.mit.edu	37	10	73494069	73494069	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr10:73494069G>A	uc001jrx.3	+	32	4554	c.4177G>A	c.(4177-4179)GAC>AAC	p.D1393N	C10orf105_uc001jsb.1_Intron|CDH23_uc001jsc.1_Missense_Mutation_p.D201N	NM_022124	NP_071407	Q9H251	CAD23_HUMAN	cadherin-like 23 isoform 1 precursor	1393	Cadherin 13.|Extracellular (Potential).				calcium ion transport|calcium-dependent cell-cell adhesion|cytosolic calcium ion homeostasis|equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	cytosol|integral to membrane|plasma membrane|stereocilium	calcium ion binding|protein binding			central_nervous_system(5)|large_intestine(4)|ovary(2)	11						GGTGGCAGATGACGGCGGCCC	0.622		NaN											0	0	0	0.004672	0	3	8									
TTC18	118491	broad.mit.edu	37	10	75051461	75051461	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr10:75051461C>G	uc009xrc.2	-	19	2288	c.2167G>C	c.(2167-2169)GAA>CAA	p.E723Q	TTC18_uc001jty.2_Missense_Mutation_p.E723Q|TTC18_uc001jtv.3_5'Flank|TTC18_uc001jtw.3_5'Flank|TTC18_uc001jtx.2_Missense_Mutation_p.E104Q	NM_145170	NP_660153	Q5T0N1	TTC18_HUMAN	tetratricopeptide repeat domain 18	723	TPR 3.						binding			ovary(2)|central_nervous_system(1)	3	Prostate(51;0.0119)					AAGAAAATTTCTGCTTGCTCA	0.418		NaN											0	0	0	0.020292	0	15	25									
ZMYND17	118490	broad.mit.edu	37	10	75184443	75184443	+	Silent	SNP	G	G	C			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr10:75184443G>C	uc001jud.2	-	7	1317	c.1251C>G	c.(1249-1251)CTC>CTG	p.L417L	ZMYND17_uc001juc.2_3'UTR|ZMYND17_uc009xrh.2_Silent_p.L440L|ZMYND17_uc009xrg.2_Silent_p.L196L	NM_001024593	NP_001019764	Q4VC12	ZMY17_HUMAN	zinc finger, MYND domain containing 17	417							zinc ion binding			ovary(1)	1	Prostate(51;0.0119)					GTTCAGGTTTGAGGGACATGA	0.463		NaN											0	0	0	0.01441	0	51	72									
SH3PXD2A	9644	broad.mit.edu	37	10	105361657	105361657	+	Silent	SNP	A	A	G			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr10:105361657A>G	uc001kxj.1	-	14	3374	c.3234T>C	c.(3232-3234)AAT>AAC	p.N1078N	SH3PXD2A_uc010qqr.1_Intron|SH3PXD2A_uc010qqs.1_Silent_p.N913N|SH3PXD2A_uc010qqt.1_Silent_p.N955N|SH3PXD2A_uc009xxn.1_Silent_p.N913N|SH3PXD2A_uc010qqu.1_Silent_p.N1021N	NM_014631	NP_055446	Q5TCZ1	SPD2A_HUMAN	SH3 multiple domains 1	1106	SH3 5.				cell communication|superoxide metabolic process	cell junction|cell projection|cytoplasm|podosome	phosphatidylinositol binding|protein binding				0		Colorectal(252;0.0815)|Breast(234;0.131)		Epithelial(162;4.09e-10)|all cancers(201;2.73e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0119)		ACCACCAGCCATTAGGGTTCC	0.552		NaN											0	0	0	0.007291	0	22	50									
INPP5F	22876	broad.mit.edu	37	10	121580377	121580377	+	Missense_Mutation	SNP	A	A	G			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr10:121580377A>G	uc001leo.2	+	16	2072	c.1906A>G	c.(1906-1908)AGA>GGA	p.R636G	INPP5F_uc001lep.2_Missense_Mutation_p.R26G	NM_014937	NP_055752	Q9Y2H2	SAC2_HUMAN	inositol polyphosphate-5-phosphatase F	636							phosphoric ester hydrolase activity			ovary(2)	2		Lung NSC(174;0.109)|all_lung(145;0.142)		all cancers(201;0.00205)|BRCA - Breast invasive adenocarcinoma(275;0.158)		TGCTACTCACAGAGACGTGGA	0.363		NaN											0	0	0	0.01441	0	44	87									
ACADSB	36	broad.mit.edu	37	10	124800022	124800022	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr10:124800022G>C	uc001lhb.2	+	4	461	c.344G>C	c.(343-345)GGA>GCA	p.G115A	ACADSB_uc010qub.1_Missense_Mutation_p.G13A	NM_001609	NP_001600	P45954	ACDSB_HUMAN	acyl-Coenzyme A dehydrogenase, short/branched	115					branched chain family amino acid catabolic process|fatty acid metabolic process	mitochondrial matrix	flavin adenine dinucleotide binding			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	3		all_neural(114;0.0765)|Colorectal(57;0.102)|all_lung(145;0.11)|Lung NSC(174;0.163)		Colorectal(40;0.0811)|COAD - Colon adenocarcinoma(40;0.0835)	L-Isoleucine(DB00167)	GGAGGCACAGGAGCTTCATTT	0.368		NaN											0	0	0	0.00874	0	41	59									
C11orf16	56673	broad.mit.edu	37	11	8947287	8947287	+	Silent	SNP	C	C	T			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr11:8947287C>T	uc001mhb.3	-	5	1051	c.927G>A	c.(925-927)TTG>TTA	p.L309L	C11orf16_uc001mhc.3_Silent_p.L309L	NM_020643	NP_065694	Q9NQ32	CK016_HUMAN	hypothetical protein LOC56673	309										upper_aerodigestive_tract(1)|pancreas(1)	2				Epithelial(150;4.11e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0234)		CTGTGGGCTCCAACTCTGGAA	0.577		NaN											0	0	0	0.01892	0	25	53									
SBF2	81846	broad.mit.edu	37	11	10022532	10022532	+	Nonsense_Mutation	SNP	C	C	A			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr11:10022532C>A	uc001mib.2	-	8	928	c.790G>T	c.(790-792)GAA>TAA	p.E264*	SBF2_uc001mif.3_Nonsense_Mutation_p.E20*	NM_030962	NP_112224	Q86WG5	MTMRD_HUMAN	SET binding factor 2	264	DENN.				myelination	cytoplasm|membrane	phosphatase activity|protein binding			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3				all cancers(16;2.88e-11)|Epithelial(150;3.61e-10)|BRCA - Breast invasive adenocarcinoma(625;0.00887)		CTTAGAACTTCCAGTAGCTGA	0.323		NaN											1	0	2.61681e-11	0.020292	2.77877e-11	13	29									
AMPD3	272	broad.mit.edu	37	11	10483070	10483070	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr11:10483070C>T	uc001mio.1	+	2	339	c.4C>T	c.(4-6)CCG>TCG	p.P2S	AMPD3_uc010rbz.1_5'UTR|AMPD3_uc001min.1_Missense_Mutation_p.P11S|AMPD3_uc009yfw.1_RNA|AMPD3_uc009yfx.1_Missense_Mutation_p.P2S|AMPD3_uc009yfz.2_RNA|AMPD3_uc001mip.1_Missense_Mutation_p.P9S|AMPD3_uc009yfy.2_Missense_Mutation_p.P2S	NM_001025389	NP_001020560	Q01432	AMPD3_HUMAN	adenosine monophosphate deaminase 3 isoform 1B	2					AMP catabolic process|purine base metabolic process|purine ribonucleoside monophosphate biosynthetic process|purine-containing compound salvage	cytosol	AMP deaminase activity|metal ion binding			large_intestine(1)|ovary(1)	2				all cancers(16;1.14e-08)|Epithelial(150;2.83e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0291)		AGCTGAGATGCCGCGGCAGTT	0.552		NaN											0	0	0	0.01441	0	83	120									
USH1C	10083	broad.mit.edu	37	11	17538984	17538984	+	Silent	SNP	A	A	G			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr11:17538984A>G	uc001mnf.2	-	15	1357	c.1248T>C	c.(1246-1248)GAT>GAC	p.D416D	USH1C_uc001mne.2_Intron|USH1C_uc009yhb.2_Silent_p.D397D|USH1C_uc001mng.2_Intron|USH1C_uc001mnd.2_Silent_p.D380D	NM_005709	NP_005700	Q9Y6N9	USH1C_HUMAN	harmonin isoform a	416					equilibrioception|G2/M transition of mitotic cell cycle|photoreceptor cell maintenance|sensory perception of sound	apical part of cell|cytoplasm|stereocilium	protein binding			ovary(1)	1						CATCCAGGTCATCTGCGGGCT	0.627		NaN											0	0	0	0.004672	0	3	3									
OR4C11	219429	broad.mit.edu	37	11	55371622	55371622	+	Silent	SNP	G	G	T			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr11:55371622G>T	uc010rii.1	-	1	228	c.228C>A	c.(226-228)GCC>GCA	p.A76A		NM_001004700	NP_001004700	Q6IEV9	OR4CB_HUMAN	olfactory receptor, family 4, subfamily C,	76	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						TTAATCTAGGGGCTGTGGAAG	0.398		NaN											1	0	1.05635e-38	0.01441	1.19573e-38	68	67									
OR5R1	219479	broad.mit.edu	37	11	56185264	56185264	+	Missense_Mutation	SNP	A	A	G			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr11:56185264A>G	uc010rji.1	-	1	445	c.445T>C	c.(445-447)TAT>CAT	p.Y149H		NM_001004744	NP_001004744	Q8NH85	OR5R1_HUMAN	olfactory receptor, family 5, subfamily R,	149	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	Esophageal squamous(21;0.00448)					CTGTATATATATGGAACTGCC	0.453		NaN											0	0	0	0.021022	0	39	81									
OR6Q1	219952	broad.mit.edu	37	11	57799250	57799250	+	Missense_Mutation	SNP	A	A	C			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr11:57799250A>C	uc010rjz.1	+	1	826	c.826A>C	c.(826-828)AAG>CAG	p.K276Q	OR9Q1_uc001nmj.2_Intron	NM_001005186	NP_001005186	Q8NGQ2	OR6Q1_HUMAN	olfactory receptor, family 6, subfamily Q,	276	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			kidney(1)	1		Breast(21;0.0707)|all_epithelial(135;0.142)				CAACTTCAACAAGGTGGTATC	0.488		NaN											0	0	0	0.004656	0	25	161									
OR9Q1	219956	broad.mit.edu	37	11	57947275	57947275	+	Missense_Mutation	SNP	A	A	G			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr11:57947275A>G	uc001nmj.2	+	3	675	c.359A>G	c.(358-360)TAT>TGT	p.Y120C		NM_001005212	NP_001005212	Q8NGQ5	OR9Q1_HUMAN	olfactory receptor, family 9, subfamily Q,	120	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		Breast(21;0.222)				CTCATGGCCTATGACCGCTAC	0.552		NaN											0	0	0	0.016522	0	20	55									
FZD4	8322	broad.mit.edu	37	11	86663440	86663440	+	Missense_Mutation	SNP	T	T	G			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr11:86663440T>G	uc001pce.2	-	2	664	c.358A>C	c.(358-360)ATG>CTG	p.M120L	PRSS23_uc001pcc.1_RNA	NM_012193	NP_036325	Q9ULV1	FZD4_HUMAN	frizzled 4 precursor	120	FZ.|Extracellular (Potential).				canonical Wnt receptor signaling pathway|cellular response to retinoic acid|embryo development|negative regulation of cell-substrate adhesion|neuron differentiation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|progesterone secretion|regulation of vascular endothelial growth factor receptor signaling pathway|substrate adhesion-dependent cell spreading|vasculogenesis|Wnt receptor signaling pathway, calcium modulating pathway	cell projection|cell surface|cytoplasm	cytokine binding|G-protein coupled receptor activity|PDZ domain binding|protein heterodimerization activity|protein homodimerization activity|Wnt receptor activity|Wnt-protein binding			large_intestine(1)	1		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)				GAAAGACACATGCCGCCGCAT	0.478		NaN											0	0	0	0.01441	0	59	101									
ENDOD1	23052	broad.mit.edu	37	11	94861970	94861970	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr11:94861970G>A	uc001pfh.2	+	2	805	c.730G>A	c.(730-732)GAC>AAC	p.D244N		NM_015036	NP_055851	O94919	ENDD1_HUMAN	endonuclease domain containing 1 precursor	244						extracellular region	endonuclease activity|metal ion binding|nucleic acid binding				0		Acute lymphoblastic leukemia(157;2.33e-05)|all_hematologic(158;0.00824)				CCGGGACAGTGACATCATAGA	0.498		NaN											0	0	0	0.021523	0	23	30									
TRPC6	7225	broad.mit.edu	37	11	101374954	101374954	+	Missense_Mutation	SNP	T	T	C			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr11:101374954T>C	uc001pgk.3	-	2	1171	c.746A>G	c.(745-747)CAT>CGT	p.H249R	TRPC6_uc009ywy.2_Missense_Mutation_p.H249R|TRPC6_uc009ywz.1_Missense_Mutation_p.H249R	NM_004621	NP_004612	Q9Y210	TRPC6_HUMAN	transient receptor potential cation channel,	249	Cytoplasmic (Potential).				axon guidance|platelet activation|positive regulation of calcium ion transport via store-operated calcium channel activity	integral to membrane|plasma membrane	protein binding			skin(2)|ovary(1)|central_nervous_system(1)	4		Acute lymphoblastic leukemia(157;0.000918)|all_hematologic(158;0.0162)		BRCA - Breast invasive adenocarcinoma(274;0.0442)		GAAATAATCATGAGGCCGTTC	0.473		NaN											0	0	0	0.003163	0	16	120									
PVRL1	5818	broad.mit.edu	37	11	119535753	119535753	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr11:119535753C>A	uc001pwv.2	-	6	1430	c.1258G>T	c.(1258-1260)GAC>TAC	p.D420Y	PVRL1_uc001pwu.1_Intron	NM_002855	NP_002846	Q15223	PVRL1_HUMAN	poliovirus receptor-related 1 isoform 1	420	Cytoplasmic (Potential).				adherens junction organization|cell junction assembly|entry of virus into host cell|heterophilic cell-cell adhesion|homophilic cell adhesion|immune response	cell-cell adherens junction|extracellular region|integral to membrane	cell adhesion molecule binding|coreceptor activity|protein homodimerization activity				0		Breast(348;0.037)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;4.29e-05)		TCTGAGTCGTCGGGGTACTGC	0.547		NaN											1	0	1.5548e-18	0.005443	1.68394e-18	26	50									
TP53AIP1	63970	broad.mit.edu	37	11	128807621	128807621	+	Silent	SNP	G	G	A			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr11:128807621G>A	uc001qey.2	-	2	303	c.93C>T	c.(91-93)CTC>CTT	p.L31L	TP53AIP1_uc001qex.2_Silent_p.L31L|TP53AIP1_uc009zcm.1_RNA			Q9HCN2	TPIP1_HUMAN	RecName: Full=p53-regulated apoptosis-inducing protein 1;          Short=p53AIP1;	31					apoptosis	mitochondrion				lung(1)	1						GCATCACCGAGAGGTTCTGGT	0.622		NaN											0	0	0	0.008871	0	17	44									
RIMKLB	57494	broad.mit.edu	37	12	8926198	8926198	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr12:8926198G>A	uc001quu.2	+	6	1230	c.979G>A	c.(979-981)GAG>AAG	p.E327K	RIMKLB_uc009zgf.1_Intron|RIMKLB_uc001qux.2_Missense_Mutation_p.E327K|RIMKLB_uc010sgl.1_Missense_Mutation_p.E327K|RIMKLB_uc001quw.2_Intron	NM_020734	NP_065785	Q9ULI2	RIMKB_HUMAN	ribosomal modification protein rimK-like family	327					protein modification process	cytoplasm	acid-amino acid ligase activity|ATP binding|metal ion binding				0						CACTGCCAGTGAGACTAGTGA	0.597		NaN											0	0	0	0.01441	0	45	35									
TAS2R50	259296	broad.mit.edu	37	12	11138589	11138589	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr12:11138589G>C	uc001qzl.2	-	1	923	c.871C>G	c.(871-873)CTT>GTT	p.L291V	PRR4_uc009zhp.2_Intron|PRH1_uc001qzb.3_Intron|PRH1_uc001qzc.2_Intron|PRB4_uc001qzf.1_Intron|PRH1_uc001qzj.2_Intron	NM_176890	NP_795371	P59544	T2R50_HUMAN	taste receptor, type 2, member 50	291	Cytoplasmic (Potential).				sensory perception of taste	integral to membrane	G-protein coupled receptor activity			ovary(2)	2						AAAATCAAAAGAAAGGTGTGT	0.398		NaN											0	0	0	0.009718	0	42	126									
H2AFJ	55766	broad.mit.edu	37	12	14927572	14927572	+	Silent	SNP	G	G	A			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr12:14927572G>A	uc009zia.2	+	1	303	c.168G>A	c.(166-168)TTG>TTA	p.L56L	H2AFJ_uc001rch.3_RNA	NM_177925	NP_808760	Q9BTM1	H2AJ_HUMAN	H2A histone family, member J	56					nucleosome assembly	nucleosome|nucleus	DNA binding			ovary(1)	1						CGGCGGTGTTGGAGTACCTTA	0.667		NaN											0	0	0	0.00499	0	14	44									
OVCH1	341350	broad.mit.edu	37	12	29630357	29630357	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr12:29630357G>T	uc001rix.1	-	11	1163	c.1163C>A	c.(1162-1164)GCC>GAC	p.A388D		NM_183378	NP_899234	Q7RTY7	OVCH1_HUMAN	ovochymase 1 precursor	388	CUB 1.				proteolysis	extracellular region	metal ion binding|serine-type endopeptidase activity			ovary(3)|central_nervous_system(3)|pancreas(3)|large_intestine(1)	10	Lung NSC(12;1.84e-09)|Acute lymphoblastic leukemia(23;0.00885)|all_hematologic(23;0.0155)					TGGAACCATGGCCTCACTGGT	0.423		NaN											1	0	3.07184e-27	0.01441	3.40619e-27	66	51									
IPO8	10526	broad.mit.edu	37	12	30829450	30829450	+	Silent	SNP	G	G	A			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr12:30829450G>A	uc001rjd.2	-	6	881	c.711C>T	c.(709-711)ATC>ATT	p.I237I	IPO8_uc010sjt.1_Silent_p.I32I	NM_006390	NP_006381	O15397	IPO8_HUMAN	importin 8	237					intracellular protein transport|signal transduction	cytoplasm|nucleus	protein transporter activity|Ran GTPase binding			skin(2)|central_nervous_system(1)	3	all_lung(12;6.66e-10)|Lung NSC(12;4.84e-08)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0355)|Lung SC(12;0.0905)|Esophageal squamous(101;0.233)					CGGTCCTGTCGATAATAGTTC	0.428		NaN											0	0	0	0.012319	0	20	75									
CPNE8	144402	broad.mit.edu	37	12	39079368	39079368	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr12:39079368C>T	uc001rls.1	-	16	1279	c.1195G>A	c.(1195-1197)GCT>ACT	p.A399T	CPNE8_uc001rlr.1_Missense_Mutation_p.A58T	NM_153634	NP_705898	Q86YQ8	CPNE8_HUMAN	copine VIII	399	VWFA.									pancreas(1)	1	Esophageal squamous(101;0.187)	Lung NSC(34;0.137)|Melanoma(24;0.152)|all_lung(34;0.157)				CTGTAATAAGCCTCCATGACC	0.398		NaN											0	0	0	0.006122	0	18	228									
KIF21A	55605	broad.mit.edu	37	12	39730987	39730987	+	Missense_Mutation	SNP	T	T	C			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr12:39730987T>C	uc001rly.2	-	17	2475	c.2329A>G	c.(2329-2331)ATG>GTG	p.M777V	KIF21A_uc001rlw.2_Missense_Mutation_p.M94V|KIF21A_uc001rlx.2_Missense_Mutation_p.M764V|KIF21A_uc001rlz.2_Missense_Mutation_p.M764V|KIF21A_uc010skl.1_Missense_Mutation_p.M764V	NM_017641	NP_060111	Q7Z4S6	KI21A_HUMAN	kinesin family member 21A	777					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(4)|pancreas(1)|lung(1)|skin(1)	7		Lung NSC(34;0.179)|all_lung(34;0.213)				TCTTCTTTCATTTGTTTCATT	0.348		NaN											0	0	0	0.010771	0	44	93									
PDZRN4	29951	broad.mit.edu	37	12	41967486	41967486	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr12:41967486G>A	uc010skn.1	+	10	2376	c.2308G>A	c.(2308-2310)GAG>AAG	p.E770K	PDZRN4_uc001rmq.3_Missense_Mutation_p.E711K|PDZRN4_uc009zjz.2_Missense_Mutation_p.E709K|PDZRN4_uc001rmr.2_Missense_Mutation_p.E596K	NM_013377	NP_037509	Q6ZMN7	PZRN4_HUMAN	PDZ domain containing RING finger 4 isoform 2	969							ubiquitin-protein ligase activity|zinc ion binding			lung(3)|skin(3)|ovary(2)|large_intestine(1)|kidney(1)|pancreas(1)	11	all_cancers(12;0.000673)	Lung NSC(34;0.0205)|all_lung(34;0.0264)				AAGCAGGTTAGAGTGTCTCAA	0.498		NaN											0	0	0	0.020292	0	14	25									
RACGAP1	29127	broad.mit.edu	37	12	50384549	50384549	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr12:50384549G>A	uc001rvt.2	-	18	2051	c.1741C>T	c.(1741-1743)CCT>TCT	p.P581S	RACGAP1_uc009zlm.1_Missense_Mutation_p.P581S|RACGAP1_uc001rvs.2_Missense_Mutation_p.P581S|RACGAP1_uc001rvu.2_Missense_Mutation_p.P581S	NM_013277	NP_037409	Q9H0H5	RGAP1_HUMAN	Rac GTPase activating protein 1	581					blood coagulation|cytokinesis, actomyosin contractile ring assembly|cytokinesis, initiation of separation|embryo development|microtubule-based movement|neuroblast proliferation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction|spermatogenesis|sulfate transport	acrosomal vesicle|cytosol|microtubule|midbody|nucleus|spindle	alpha-tubulin binding|beta-tubulin binding|gamma-tubulin binding|GTPase activator activity|metal ion binding			kidney(1)	1						TGATGTTCAGGAGTGGTCACA	0.438		NaN											0	0	0	0.008361	0	28	87									
DIP2B	57609	broad.mit.edu	37	12	51090911	51090911	+	Silent	SNP	C	C	A			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr12:51090911C>A	uc001rwv.2	+	17	2157	c.2001C>A	c.(1999-2001)ATC>ATA	p.I667I	DIP2B_uc009zlt.2_Silent_p.I97I	NM_173602	NP_775873	Q9P265	DIP2B_HUMAN	DIP2 disco-interacting protein 2 homolog B	667						nucleus	catalytic activity|transcription factor binding			ovary(4)|breast(1)|pancreas(1)	6						CTGAGGCCATCTGTCCGTGCG	0.498		NaN											1	0	2.0095e-06	0.001984	2.06005e-06	7	29									
ESPL1	9700	broad.mit.edu	37	12	53676162	53676162	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr12:53676162C>G	uc001sck.2	+	14	2825	c.2734C>G	c.(2734-2736)CTT>GTT	p.L912V	ESPL1_uc001scj.2_Missense_Mutation_p.L587V|ESPL1_uc010soe.1_Missense_Mutation_p.L123V	NM_012291	NP_036423	Q14674	ESPL1_HUMAN	separase	912					apoptosis|cytokinesis|establishment of mitotic spindle localization|mitotic sister chromatid segregation|negative regulation of sister chromatid cohesion|positive regulation of mitotic metaphase/anaphase transition|proteolysis	centrosome|nucleus	cysteine-type peptidase activity|protein binding			lung(1)|kidney(1)|skin(1)	3						GGCAGCTTACCTTAGCCTCCC	0.577		NaN											0	0	0	0.014323	0	22	64									
TPH2	121278	broad.mit.edu	37	12	72388270	72388270	+	Silent	SNP	G	G	A			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr12:72388270G>A	uc009zrw.1	+	8	1134	c.993G>A	c.(991-993)AAG>AAA	p.K331K	TPH2_uc001swy.2_Silent_p.K241K	NM_173353	NP_775489	Q8IWU9	TPH2_HUMAN	tryptophan hydroxylase 2	331					aromatic amino acid family metabolic process|hormone biosynthetic process|serotonin biosynthetic process	cytosol	amino acid binding|iron ion binding|tryptophan 5-monooxygenase activity			ovary(2)|central_nervous_system(1)|skin(1)	4					L-Tryptophan(DB00150)	CGGATCCTAAGTTTGCTCAGT	0.403		NaN											0	0	0	0.015359	0	31	132									
PITPNM2	57605	broad.mit.edu	37	12	123471235	123471235	+	Silent	SNP	C	C	T	rs147680163	byFrequency	TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr12:123471235C>T	uc001uej.1	-	23	3694	c.3555G>A	c.(3553-3555)CCG>CCA	p.P1185P	PITPNM2_uc001uek.1_Silent_p.P1179P	NM_020845	NP_065896	Q9BZ72	PITM2_HUMAN	phosphatidylinositol transfer protein,	1185					metabolic process|transport	endomembrane system|integral to membrane|intracellular membrane-bounded organelle	calcium ion binding|lipid binding			ovary(1)|central_nervous_system(1)|skin(1)	3	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;2.55e-05)|Epithelial(86;8.43e-05)|BRCA - Breast invasive adenocarcinoma(302;0.123)		TGTGCCGCAGCGGGTCATGCA	0.687		NaN											0	0	0	0.009096	0	3	19									
KATNAL1	84056	broad.mit.edu	37	13	30829724	30829724	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr13:30829724G>A	uc001uss.2	-	4	453	c.352C>T	c.(352-354)CGA>TGA	p.R118*	KATNAL1_uc001ust.2_Nonsense_Mutation_p.R118*	NM_001014380	NP_001014402	Q9BW62	KATL1_HUMAN	katanin p60 subunit A-like 1	118						cytoplasm|microtubule	ATP binding|microtubule-severing ATPase activity				0		Lung SC(185;0.0257)		all cancers(112;0.114)|OV - Ovarian serous cystadenocarcinoma(117;0.213)		CTTACTTCTCGATTGGGACGC	0.388		NaN											0	0	0	0.01441	0	176	78									
BRCA2	675	broad.mit.edu	37	13	32929379	32929379	+	Silent	SNP	T	T	C			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr13:32929379T>C	uc001uub.1	+	14	7616	c.7389T>C	c.(7387-7389)AAT>AAC	p.N2463N		NM_000059	NP_000050	P51587	BRCA2_HUMAN	breast cancer 2, early onset	2463	Interaction with FANCD2.				cell cycle cytokinesis|centrosome duplication|double-strand break repair via homologous recombination|negative regulation of mammary gland epithelial cell proliferation|nucleotide-excision repair|positive regulation of transcription, DNA-dependent|regulation of S phase of mitotic cell cycle	BRCA2-MAGE-D1 complex|centrosome|nucleoplasm|stored secretory granule	gamma-tubulin binding|H3 histone acetyltransferase activity|H4 histone acetyltransferase activity|protease binding|single-stranded DNA binding			ovary(20)|endometrium(8)|lung(7)|breast(7)|oesophagus(5)|large_intestine(4)|central_nervous_system(3)|pancreas(3)|skin(2)|upper_aerodigestive_tract(1)|cervix(1)|salivary_gland(1)|liver(1)|kidney(1)	64		Lung SC(185;0.0262)		all cancers(112;7.13e-07)|Epithelial(112;1.59e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.000732)|BRCA - Breast invasive adenocarcinoma(63;0.0291)|GBM - Glioblastoma multiforme(144;0.0704)		ACAACTCCAATCAAGCAGTAG	0.323		NaN	D|Mis|N|F|S		breast|ovarian|pancreatic	breast|ovarian|pancreatic|leukemia  (FANCB|FANCD1)		Direct_reversal_of_damage|Homologous_recombination	Fanconi_Anemia_type_D1_bi-allelic_BRCA2_mutations|Fanconi_Anemia|Pancreatic_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_BRCA2_type|Hereditary_Prostate_Cancer|Li-Fraumeni_syndrome	TCGA Ovarian(8;0.087)			0	0	0	0.008871	0	20	37									
TDRD3	81550	broad.mit.edu	37	13	61057916	61057916	+	Nonsense_Mutation	SNP	C	C	G			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr13:61057916C>G	uc001via.2	+	6	1012	c.224C>G	c.(223-225)TCA>TGA	p.S75*	TDRD3_uc010aef.2_Translation_Start_Site|TDRD3_uc001vhz.3_Nonsense_Mutation_p.S75*|TDRD3_uc010aeg.2_Nonsense_Mutation_p.S168*|TDRD3_uc001vib.3_Nonsense_Mutation_p.S75*	NM_030794	NP_110421	Q9H7E2	TDRD3_HUMAN	tudor domain containing 3 isoform 2	75					chromatin modification	cytoplasm|nucleus	chromatin binding|methylated histone residue binding|nucleic acid binding|transcription coactivator activity			upper_aerodigestive_tract(1)|skin(1)	2		Prostate(109;0.173)|Breast(118;0.174)		GBM - Glioblastoma multiforme(99;0.000291)		CAGAGCTTATCAAAACACAAT	0.348		NaN											0	0	0	0.01441	0	46	128									
FAM179B	23116	broad.mit.edu	37	14	45432544	45432544	+	Missense_Mutation	SNP	A	A	G			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr14:45432544A>G	uc001wvv.2	+	1	1129	c.920A>G	c.(919-921)TAC>TGC	p.Y307C	FAM179B_uc001wvw.2_Missense_Mutation_p.Y307C|FAM179B_uc010anc.2_RNA|KLHL28_uc001wvq.2_5'Flank|KLHL28_uc001wvr.2_5'Flank|FAM179B_uc010anb.1_Missense_Mutation_p.Y307C|FAM179B_uc001wvu.2_Missense_Mutation_p.Y307C	NM_015091	NP_055906	Q9Y4F4	F179B_HUMAN	hypothetical protein LOC23116	307							binding			skin(2)|upper_aerodigestive_tract(1)	3						AGGAGACACTACAATCGCCGC	0.502		NaN											0	0	0	0.019004	0	33	64									
PTGER2	5732	broad.mit.edu	37	14	52781858	52781858	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr14:52781858C>G	uc001wzr.2	+	1	843	c.592C>G	c.(592-594)CAG>GAG	p.Q198E		NM_000956	NP_000947	P43116	PE2R2_HUMAN	prostaglandin E receptor 2 (subtype EP2), 53kDa	198	Extracellular (Potential).					integral to plasma membrane	prostaglandin E receptor activity			lung(1)|breast(1)	2	Breast(41;0.0639)|all_epithelial(31;0.0729)				Alprostadil(DB00770)|Iloprost(DB01088)	CGCTTACCTGCAGCTGTACGC	0.627		NaN											0	0	0	0.014758	0	3	31									
C14orf174	161394	broad.mit.edu	37	14	77845304	77845304	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr14:77845304G>C	uc001xtq.1	+	1	1543	c.1543G>C	c.(1543-1545)GAT>CAT	p.D515H	TMED8_uc010ast.1_5'Flank|TMED8_uc001xto.1_5'Flank	NM_001010860	NP_001010860	Q9P1V8	SAM15_HUMAN	hypothetical protein LOC161394	515											0			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0278)		GGAAGTTGTAGATTTGTCCCA	0.413		NaN											0	0	0	0.005524	0	37	67									
GPR68	8111	broad.mit.edu	37	14	91700947	91700947	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr14:91700947G>T	uc001xzg.2	-	2	789	c.448C>A	c.(448-450)CTG>ATG	p.L150M	GPR68_uc001xzh.2_Missense_Mutation_p.L160M	NM_003485	NP_003476	Q15743	OGR1_HUMAN	G protein-coupled receptor 68	150	Helical; Name=4; (Potential).				inflammatory response	integral to plasma membrane	G-protein coupled receptor activity			kidney(1)	1		all_cancers(154;0.0555)		COAD - Colon adenocarcinoma(157;0.21)		CTGGTCAGCAGCTCCTTGGCC	0.637		NaN											1	0	4.68919e-08	0.008291	4.85294e-08	11	15									
ATG2B	55102	broad.mit.edu	37	14	96757944	96757944	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr14:96757944G>A	uc001yfi.2	-	38	5937	c.5572C>T	c.(5572-5574)CGA>TGA	p.R1858*		NM_018036	NP_060506	Q96BY7	ATG2B_HUMAN	ATG2 autophagy related 2 homolog B	1858										ovary(1)|kidney(1)|skin(1)	3		all_cancers(154;0.0462)|all_epithelial(191;0.123)|Melanoma(154;0.155)		Epithelial(152;0.21)|COAD - Colon adenocarcinoma(157;0.244)		TACCCATGTCGATAGGAAAGC	0.348		NaN											0	0	0	0.011902	0	41	180									
MGA	23269	broad.mit.edu	37	15	41961492	41961492	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr15:41961492C>T	uc001zog.1	+	2	491	c.400C>T	c.(400-402)CGT>TGT	p.R134C	MGA_uc010ucy.1_Missense_Mutation_p.R134C|MGA_uc010ucz.1_Missense_Mutation_p.R134C	NM_001080541	NP_001074010	Q8IWI9	MGAP_HUMAN	MAX-interacting protein isoform 2	134	T-box.					MLL1 complex	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(6)|kidney(3)|upper_aerodigestive_tract(1)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	12		all_cancers(109;0.00356)|all_epithelial(112;0.0413)|all_lung(180;0.18)|Ovarian(310;0.238)		OV - Ovarian serous cystadenocarcinoma(18;1.41e-18)|GBM - Glioblastoma multiforme(113;2.15e-06)|COAD - Colon adenocarcinoma(120;0.031)|Lung(196;0.0721)|BRCA - Breast invasive adenocarcinoma(123;0.0964)|Colorectal(105;0.0998)|LUSC - Lung squamous cell carcinoma(244;0.235)		GGATAACCATCGTTATAAGTG	0.418		NaN											0	0	0	0.01441	0	130	245									
FBN1	2200	broad.mit.edu	37	15	48776085	48776085	+	Missense_Mutation	SNP	A	A	T			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr15:48776085A>T	uc001zwx.1	-	31	4096	c.3768T>A	c.(3766-3768)AAT>AAA	p.N1256K		NM_000138	NP_000129	P35555	FBN1_HUMAN	fibrillin 1 precursor	1256	EGF-like 20; calcium-binding.				heart development|negative regulation of BMP signaling pathway by extracellular sequestering of BMP|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|skeletal system development	basement membrane|extracellular space|microfibril	calcium ion binding|extracellular matrix structural constituent|protein binding			ovary(2)|large_intestine(1)	3		all_lung(180;0.00279)		all cancers(107;4.24e-07)|GBM - Glioblastoma multiforme(94;1.41e-05)		CTCCAGGGATATTTGTGCACT	0.398		NaN											0	0	0	0.01441	0	57	66									
KIAA1370	56204	broad.mit.edu	37	15	52901214	52901214	+	Missense_Mutation	SNP	T	T	C			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr15:52901214T>C	uc002acg.3	-	6	2050	c.1897A>G	c.(1897-1899)ATG>GTG	p.M633V	KIAA1370_uc002ach.3_RNA|KIAA1370_uc010bfg.1_Missense_Mutation_p.M545V|KIAA1370_uc010ugf.1_Missense_Mutation_p.M640V	NM_019600	NP_062546	Q32MH5	K1370_HUMAN	hypothetical protein LOC56204	633											0				all cancers(107;0.0803)		CCATTGCTCATTTCTTGCTCC	0.303		NaN											0	0	0	0.01441	0	44	170									
UNC13C	440279	broad.mit.edu	37	15	54306851	54306851	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr15:54306851G>T	uc002ack.2	+	1	1751	c.1751G>T	c.(1750-1752)CGG>CTG	p.R584L		NM_001080534	NP_001074003	Q8NB66	UN13C_HUMAN	unc-13 homolog C	584					exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			ovary(5)|pancreas(2)	7				GBM - Glioblastoma multiforme(80;0.0789)|all cancers(107;0.124)		TCTTCGGACCGGGAGCTATGG	0.453		NaN											1	0	1.87028e-06	0.012319	1.92338e-06	21	48									
RPLP1	6176	broad.mit.edu	37	15	69746006	69746006	+	Silent	SNP	C	C	T			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr15:69746006C>T	uc002asd.1	+	2	222	c.93C>T	c.(91-93)CTC>CTT	p.L31L	RPLP1_uc002ase.1_Intron	NM_001003	NP_000994	P05386	RLA1_HUMAN	ribosomal protein P1 isoform 1	31					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit	protein binding|RNA binding|structural constituent of ribosome				0						TCAATGCCCTCATTAAAGCAG	0.418		NaN											0	0	0	0.01441	0	68	69									
GRAMD2	196996	broad.mit.edu	37	15	72459414	72459414	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr15:72459414G>A	uc002atq.2	-	6	416	c.392C>T	c.(391-393)TCT>TTT	p.S131F	GRAMD2_uc010bis.2_Missense_Mutation_p.S131F	NM_001012642	NP_001012660	Q8IUY3	GRAM2_HUMAN	GRAM domain containing 2	131	GRAM.					integral to membrane					0						CATTTGCACAGACACCACAGG	0.567		NaN											0	0	0	0.004482	0	9	45									
SCAPER	49855	broad.mit.edu	37	15	76726455	76726455	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr15:76726455C>T	uc002bby.2	-	25	3334	c.3275G>A	c.(3274-3276)GGT>GAT	p.G1092D	SCAPER_uc010bkr.2_Missense_Mutation_p.G400D|SCAPER_uc002bbx.2_Missense_Mutation_p.G846D|SCAPER_uc002bbz.1_Missense_Mutation_p.G963D	NM_020843	NP_065894	Q9BY12	SCAPE_HUMAN	S-phase cyclin A-associated protein in the ER	1091						endoplasmic reticulum|nucleus	zinc ion binding			large_intestine(1)|lung(1)|ovary(1)	3						AAAAGGATCACCTTGTGAGGG	0.373		NaN											0	0	0	0.00499	0	18	39									
CREBBP	1387	broad.mit.edu	37	16	3786148	3786148	+	Nonsense_Mutation	SNP	A	A	C			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08			A	C	A	A		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr16:3786148A>C	uc002cvv.2	-	28	4821	c.4617T>G	c.(4615-4617)TAT>TAG	p.Y1539*	CREBBP_uc002cvw.2_Nonsense_Mutation_p.Y1501*	NM_004380	NP_004371	Q92793	CBP_HUMAN	CREB binding protein isoform a	1539	Interaction with TRERF1.				cellular lipid metabolic process|homeostatic process|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|protein complex assembly|response to hypoxia	cytoplasm|nuclear body	histone acetyltransferase activity|MyoD binding|p53 binding|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription coactivator activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(97)|ovary(14)|lung(6)|skin(6)|breast(2)|NS(1)|pancreas(1)	127		Ovarian(90;0.0266)		OV - Ovarian serous cystadenocarcinoma(1;3.54e-05)		CACCTTCAAAATAGGGCAGTT	0.478		NaN	T|N|F|Mis|O	MLL|MORF|RUNXBP2	ALL|AML|DLBCL|B-NHL 		Rubinstein-Taybi syndrome		Rubinstein-Taybi_syndrome				0	0	0	0.01441	0	80	63									
CREBBP	1387	broad.mit.edu	37	16	3828045	3828045	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08			C	G	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr16:3828045C>G	uc002cvv.2	-	10	2284	c.2080G>C	c.(2080-2082)GTG>CTG	p.V694L	CREBBP_uc002cvw.2_Missense_Mutation_p.V656L	NM_004380	NP_004371	Q92793	CBP_HUMAN	CREB binding protein isoform a	694					cellular lipid metabolic process|homeostatic process|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|protein complex assembly|response to hypoxia	cytoplasm|nuclear body	histone acetyltransferase activity|MyoD binding|p53 binding|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription coactivator activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(97)|ovary(14)|lung(6)|skin(6)|breast(2)|NS(1)|pancreas(1)	127		Ovarian(90;0.0266)		OV - Ovarian serous cystadenocarcinoma(1;3.54e-05)		TGTGGAATCACAGGGGGCTGA	0.502		NaN	T|N|F|Mis|O	MLL|MORF|RUNXBP2	ALL|AML|DLBCL|B-NHL 		Rubinstein-Taybi syndrome		Rubinstein-Taybi_syndrome				0	0	0	0.012213	0	31	148									
CIITA	4261	broad.mit.edu	37	16	10971204	10971204	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr16:10971204C>T	uc002dai.3	+	1	150	c.17C>T	c.(16-18)CCA>CTA	p.P6L	CIITA_uc002daj.3_Missense_Mutation_p.P6L|CIITA_uc002dak.3_Missense_Mutation_p.P6L|CIITA_uc002dag.2_Missense_Mutation_p.P6L|CIITA_uc002dah.2_Missense_Mutation_p.P6L|CIITA_uc010bup.1_Missense_Mutation_p.P6L	NM_000246	NP_000237	P33076	C2TA_HUMAN	class II transactivator	6					interferon-gamma-mediated signaling pathway|negative regulation of transcription from RNA polymerase II promoter|positive regulation of MHC class I biosynthetic process|positive regulation of transcription from RNA polymerase II promoter|response to antibiotic|transcription, DNA-dependent	nucleus	activating transcription factor binding|ATP binding|protein C-terminus binding|protein complex binding|transcription coactivator activity|transcription regulatory region DNA binding			central_nervous_system(1)	1						TGCCTGGCTCCACGCCCTGCT	0.597		NaN	T	FLJ27352|CD274|CD273|RALGDS|RUNDC2A|C16orf75	PMBL|Hodgkin Lymphona|								0	0	0	0.001984	0	7	6									
MYST1	84148	broad.mit.edu	37	16	31141847	31141847	+	Silent	SNP	C	C	T			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr16:31141847C>T	uc002eay.2	+	9	1095	c.1077C>T	c.(1075-1077)CTC>CTT	p.L359L	MYST1_uc002eax.2_Silent_p.L359L|MYST1_uc002eaz.2_Silent_p.L201L|MYST1_uc002eba.2_Silent_p.L143L|MYST1_uc002ebb.2_RNA	NM_032188	NP_115564	Q9H7Z6	MYST1_HUMAN	MYST histone acetyltransferase 1 isoform 1	359					histone H4-K16 acetylation|myeloid cell differentiation|negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	MLL1 complex|MSL complex	histone acetyltransferase activity|metal ion binding|methylated histone residue binding|transcription factor binding			ovary(1)	1						TGGGCAAGCTCAGCTACCGCA	0.612		NaN											0	0	0	0.013537	0	8	15									
CA7	766	broad.mit.edu	37	16	66881069	66881069	+	Silent	SNP	C	C	T			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr16:66881069C>T	uc002eqi.2	+	2	286	c.177C>T	c.(175-177)CTC>CTT	p.L59L	uc002eqh.2_Intron|CA7_uc002eqj.2_Silent_p.L3L	NM_005182	NP_005173	P43166	CAH7_HUMAN	carbonic anhydrase VII isoform 1	59					one-carbon metabolic process	cytoplasm	carbonate dehydratase activity|zinc ion binding				0		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.088)|Epithelial(162;0.204)		GCATGTCCCTCAGCATCACCA	0.572		NaN											0	0	0	0.00499	0	17	20									
PKD1L2	114780	broad.mit.edu	37	16	81161440	81161440	+	Silent	SNP	G	G	A	rs117399993	by1000genomes	TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr16:81161440G>A	uc002fgh.1	-	38	6276	c.6276C>T	c.(6274-6276)ATC>ATT	p.I2092I	PKD1L2_uc002fgf.1_5'UTR|PKD1L2_uc002fgg.1_RNA	NM_052892	NP_443124	Q7Z442	PK1L2_HUMAN	polycystin 1-like 2 isoform a	2092	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity|sugar binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3						GTTTGCCCCAGATGGGATACC	0.547		NaN											0	0	0	0.010729	0	11	38									
ABR	29	broad.mit.edu	37	17	1003885	1003885	+	Silent	SNP	G	G	A			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr17:1003885G>A	uc002fsd.2	-	3	447	c.337C>T	c.(337-339)CTG>TTG	p.L113L	ABR_uc002fse.2_Silent_p.L67L|ABR_uc002fsg.2_Silent_p.L76L|ABR_uc010cjq.1_Silent_p.L125L	NM_021962	NP_068781	Q12979	ABR_HUMAN	active breakpoint cluster region-related	113	DH.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|protein binding|Rho guanyl-nucleotide exchange factor activity			upper_aerodigestive_tract(1)	1				UCEC - Uterine corpus endometrioid carcinoma (25;0.0228)		ACCAGCAACAGGGCTTCCAGC	0.572		NaN											0	0	0	0.00632	0	29	20									
ABR	29	broad.mit.edu	37	17	1003907	1003907	+	Silent	SNP	G	G	A			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr17:1003907G>A	uc002fsd.2	-	3	425	c.315C>T	c.(313-315)ATC>ATT	p.I105I	ABR_uc002fse.2_Silent_p.I59I|ABR_uc002fsg.2_Silent_p.I68I|ABR_uc010cjq.1_Silent_p.I117I	NM_021962	NP_068781	Q12979	ABR_HUMAN	active breakpoint cluster region-related	105	DH.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|protein binding|Rho guanyl-nucleotide exchange factor activity			upper_aerodigestive_tract(1)	1				UCEC - Uterine corpus endometrioid carcinoma (25;0.0228)		GGTTAATGTAGATCTCTTCGC	0.582		NaN											0	0	0	0.010771	0	45	22									
TP53	7157	broad.mit.edu	37	17	7578475	7578475	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr17:7578475G>A	uc002gim.2	-	5	649	c.455C>T	c.(454-456)CCG>CTG	p.P152L	TP53_uc002gig.1_Missense_Mutation_p.P152L|TP53_uc002gih.2_Missense_Mutation_p.P152L|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.P20L|TP53_uc010cng.1_Missense_Mutation_p.P20L|TP53_uc002gii.1_Missense_Mutation_p.P20L|TP53_uc010cnh.1_Missense_Mutation_p.P152L|TP53_uc010cni.1_Missense_Mutation_p.P152L|TP53_uc002gij.2_Missense_Mutation_p.P152L|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.P59L|TP53_uc002gio.2_Missense_Mutation_p.P20L|TP53_uc010vug.1_Missense_Mutation_p.P113L	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	152	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		P -> R (in sporadic cancers; somatic mutation).|P -> T (in sporadic cancers; somatic mutation).|P -> L (in LFS; germline mutation and in sporadic cancers; somatic mutation).|P -> Q (in sporadic cancers; somatic mutation).|P -> S (in sporadic cancers; somatic mutation).|P -> A (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.P152L(57)|p.P152S(21)|p.P152fs*18(17)|p.P152T(7)|p.0?(7)|p.P152fs*29(5)|p.P152P(5)|p.P152Q(4)|p.P153fs*28(4)|p.P152fs*14(4)|p.P152fs*28(3)|p.P152R(3)|p.T150fs*16(3)|p.P152A(2)|p.P153fs*16(1)|p.P151_V173del23(1)|p.P152_P153del(1)|p.D148_T155delDSTPPPGT(1)|p.T150_P153delTPPP(1)|p.D148fs*23(1)|p.P152del(1)|p.S149fs*72(1)|p.S149fs*17(1)|p.Q144_G154del11(1)|p.P152_P153insXXX(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GGTGCCGGGCGGGGGTGTGGA	0.612		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			0	0	0	0.00623	0	35	5									
MYH13	8735	broad.mit.edu	37	17	10206521	10206521	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr17:10206521C>T	uc002gmk.1	-	39	5749	c.5659G>A	c.(5659-5661)GAG>AAG	p.E1887K		NM_003802	NP_003793	Q9UKX3	MYH13_HUMAN	myosin, heavy polypeptide 13, skeletal muscle	1887	Potential.				muscle contraction	muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(4)|skin(2)	6						ACCGCCTCCTCAGCCTGCCTC	0.592		NaN											0	0	0	0.021022	0	38	42									
SLC47A1	55244	broad.mit.edu	37	17	19480737	19480737	+	Silent	SNP	G	G	A			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr17:19480737G>A	uc002gvy.1	+	17	1670	c.1584G>A	c.(1582-1584)CCG>CCA	p.P528P	SLC47A1_uc002gvx.2_Silent_p.P528P|SLC47A1_uc010vyz.1_3'UTR|SLC47A1_uc010cqp.1_Silent_p.P226P|SLC47A1_uc010cqq.1_Silent_p.P274P|SLC47A1_uc010vza.1_Silent_p.P240P|SLC47A1_uc010vzb.1_Silent_p.P203P|SLC47A1_uc010vzc.1_Silent_p.P200P	NM_018242	NP_060712	Q96FL8	S47A1_HUMAN	solute carrier family 47, member 1	528	Cytoplasmic (Potential).					integral to membrane|plasma membrane	drug:hydrogen antiporter activity				0	all_cancers(12;2.49e-05)|all_epithelial(12;0.00263)|Hepatocellular(7;0.00345)					AACCTTTGCCGGAACATCCAC	0.532		NaN											0	0	0	0.006999	0	38	157									
CPD	1362	broad.mit.edu	37	17	28712233	28712233	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr17:28712233G>A	uc002hfb.1	+	2	988	c.973G>A	c.(973-975)GCA>ACA	p.A325T	CPD_uc010wbo.1_Missense_Mutation_p.A78T|CPD_uc010wbp.1_RNA	NM_001304	NP_001295	O75976	CBPD_HUMAN	carboxypeptidase D precursor	325	Extracellular (Potential).|Carboxypeptidase-like 1.				proteolysis	integral to membrane	metallocarboxypeptidase activity|serine-type carboxypeptidase activity|zinc ion binding			liver(1)|skin(1)	2						CACAAACGGCGCACATTGGTA	0.413		NaN											0	0	0	0.01441	0	149	279									
COPZ2	51226	broad.mit.edu	37	17	46111232	46111232	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr17:46111232C>G	uc002imy.2	-	7	278	c.265G>C	c.(265-267)GAG>CAG	p.E89Q		NM_016429	NP_057513	Q9P299	COPZ2_HUMAN	coatomer protein complex, subunit zeta 2	89					intracellular protein transport|vesicle-mediated transport	cis-Golgi network|COPI vesicle coat					0						CACTTACTCTCAGTCCGGCTG	0.483		NaN											0	0	0	0.001168	0	6	24									
CACNA1G	8913	broad.mit.edu	37	17	48681582	48681582	+	Silent	SNP	C	C	A			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr17:48681582C>A	uc002irk.1	+	22	4608	c.4236C>A	c.(4234-4236)ATC>ATA	p.I1412I	CACNA1G_uc002iri.1_Silent_p.I1412I|CACNA1G_uc002irj.1_Silent_p.I1389I|CACNA1G_uc002irl.1_Silent_p.I1389I|CACNA1G_uc002irm.1_Silent_p.I1389I|CACNA1G_uc002irn.1_Silent_p.I1389I|CACNA1G_uc002iro.1_Silent_p.I1389I|CACNA1G_uc002irp.1_Silent_p.I1412I|CACNA1G_uc002irq.1_Silent_p.I1389I|CACNA1G_uc002irr.1_Silent_p.I1412I|CACNA1G_uc002irs.1_Silent_p.I1412I|CACNA1G_uc002irt.1_Silent_p.I1412I|CACNA1G_uc002irv.1_Silent_p.I1412I|CACNA1G_uc002irw.1_Silent_p.I1389I|CACNA1G_uc002iru.1_Silent_p.I1389I|CACNA1G_uc002irx.1_Silent_p.I1325I|CACNA1G_uc002iry.1_Silent_p.I1325I|CACNA1G_uc002irz.1_Silent_p.I1325I|CACNA1G_uc002isa.1_Silent_p.I1325I|CACNA1G_uc002isb.1_Silent_p.I1325I|CACNA1G_uc002isc.1_Silent_p.I1325I|CACNA1G_uc002isd.1_Silent_p.I1325I|CACNA1G_uc002ise.1_Silent_p.I1325I|CACNA1G_uc002isf.1_Silent_p.I1325I|CACNA1G_uc002isg.1_Silent_p.I1325I|CACNA1G_uc002ish.1_Silent_p.I1325I|CACNA1G_uc002isi.1_Silent_p.I1302I|CACNA1G_uc002isj.2_Silent_p.I136I	NM_018896	NP_061496	O43497	CAC1G_HUMAN	voltage-dependent calcium channel alpha 1G	1412	Helical; Name=S5 of repeat III; (Potential).|III.				axon guidance	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(1)	1	Breast(11;6.7e-17)		BRCA - Breast invasive adenocarcinoma(22;7.52e-09)		Ethosuximide(DB00593)|Flunarizine(DB04841)|Levetiracetam(DB01202)|Mibefradil(DB01388)|Pimozide(DB01100)|Trimethadione(DB00347)|Verapamil(DB00661)|Zonisamide(DB00909)	TGAAACCCATCGGCAACATTG	0.597		NaN											1	0	1.16021e-09	0.007291	1.21617e-09	31	110									
CACNA1G	8913	broad.mit.edu	37	17	48681612	48681612	+	Silent	SNP	C	C	T			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr17:48681612C>T	uc002irk.1	+	22	4638	c.4266C>T	c.(4264-4266)TTC>TTT	p.F1422F	CACNA1G_uc002iri.1_Silent_p.F1422F|CACNA1G_uc002irj.1_Silent_p.F1399F|CACNA1G_uc002irl.1_Silent_p.F1399F|CACNA1G_uc002irm.1_Silent_p.F1399F|CACNA1G_uc002irn.1_Silent_p.F1399F|CACNA1G_uc002iro.1_Silent_p.F1399F|CACNA1G_uc002irp.1_Silent_p.F1422F|CACNA1G_uc002irq.1_Silent_p.F1399F|CACNA1G_uc002irr.1_Silent_p.F1422F|CACNA1G_uc002irs.1_Silent_p.F1422F|CACNA1G_uc002irt.1_Silent_p.F1422F|CACNA1G_uc002irv.1_Silent_p.F1422F|CACNA1G_uc002irw.1_Silent_p.F1399F|CACNA1G_uc002iru.1_Silent_p.F1399F|CACNA1G_uc002irx.1_Silent_p.F1335F|CACNA1G_uc002iry.1_Silent_p.F1335F|CACNA1G_uc002irz.1_Silent_p.F1335F|CACNA1G_uc002isa.1_Silent_p.F1335F|CACNA1G_uc002isb.1_Silent_p.F1335F|CACNA1G_uc002isc.1_Silent_p.F1335F|CACNA1G_uc002isd.1_Silent_p.F1335F|CACNA1G_uc002ise.1_Silent_p.F1335F|CACNA1G_uc002isf.1_Silent_p.F1335F|CACNA1G_uc002isg.1_Silent_p.F1335F|CACNA1G_uc002ish.1_Silent_p.F1335F|CACNA1G_uc002isi.1_Silent_p.F1312F|CACNA1G_uc002isj.2_Silent_p.F146F	NM_018896	NP_061496	O43497	CAC1G_HUMAN	voltage-dependent calcium channel alpha 1G	1422	Helical; Name=S5 of repeat III; (Potential).|III.				axon guidance	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(1)	1	Breast(11;6.7e-17)		BRCA - Breast invasive adenocarcinoma(22;7.52e-09)		Ethosuximide(DB00593)|Flunarizine(DB04841)|Levetiracetam(DB01202)|Mibefradil(DB01388)|Pimozide(DB01100)|Trimethadione(DB00347)|Verapamil(DB00661)|Zonisamide(DB00909)	GCTGTGCCTTCTTCATCATTT	0.607		NaN											0	0	0	0.019004	0	32	129									
ABCC3	8714	broad.mit.edu	37	17	48761367	48761367	+	Missense_Mutation	SNP	C	C	A	rs141762939		TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr17:48761367C>A	uc002isl.2	+	28	4092	c.4012C>A	c.(4012-4014)CGC>AGC	p.R1338S	ABCC3_uc002isn.2_Missense_Mutation_p.R92S	NM_003786	NP_003777	O15438	MRP3_HUMAN	ATP-binding cassette, sub-family C, member 3	1338	Cytoplasmic (By similarity).|ABC transporter 2.				bile acid metabolic process	integral to plasma membrane|membrane fraction	ATP binding|bile acid-exporting ATPase activity|organic anion transmembrane transporter activity			skin(3)|central_nervous_system(1)	4			BRCA - Breast invasive adenocarcinoma(22;3.05e-09)		Glibenclamide(DB01016)	TTGCCTGTTCCGCATCCTGGA	0.622		NaN											1	0	9.84934e-19	0.010771	1.07029e-18	42	18									
GNA13	10672	broad.mit.edu	37	17	63052540	63052540	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr17:63052540C>T	uc002jfc.2	-	1	381	c.172G>A	c.(172-174)GAG>AAG	p.E58K	GNA13_uc010wqh.1_5'Flank	NM_006572	NP_006563	Q14344	GNA13_HUMAN	guanine nucleotide binding protein (G protein),	58	GTP (By similarity).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase D activity|cellular component movement|platelet activation|Rho protein signal transduction	brush border membrane|heterotrimeric G-protein complex|melanosome	D5 dopamine receptor binding|G-protein beta/gamma-subunit complex binding|GTP binding|GTPase activity|signal transducer activity|type 1 angiotensin receptor binding				0						TTGCCGCTCTCGCCCGCGCCC	0.617		NaN											0	0	0	0.013726	0	34	124									
CCDC46	201134	broad.mit.edu	37	17	64171210	64171210	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr17:64171210G>C	uc002jfl.2	-	4	641	c.422C>G	c.(421-423)TCT>TGT	p.S141C	CCDC46_uc002jfm.2_Missense_Mutation_p.S141C|CCDC46_uc010dep.2_Missense_Mutation_p.S141C	NM_145036	NP_659473	Q8N8E3	CE112_HUMAN	coiled-coil domain containing 46 isoform a	141						centrosome					0			BRCA - Breast invasive adenocarcinoma(6;1.53e-06)			TTCTCCAGAAGAGAGTTTCCA	0.423		NaN											0	0	0	0.012213	0	33	187									
DSC1	1823	broad.mit.edu	37	18	28736055	28736055	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr18:28736055G>T	uc002kwn.2	-	4	684	c.422C>A	c.(421-423)GCT>GAT	p.A141D	DSC1_uc002kwm.2_Missense_Mutation_p.A141D	NM_024421	NP_077739	Q08554	DSC1_HUMAN	desmocollin 1 isoform Dsc1a preproprotein	141	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion	desmosome|gap junction|integral to membrane|membrane fraction	calcium ion binding			ovary(3)|skin(1)	4			OV - Ovarian serous cystadenocarcinoma(10;0.00778)			CATCAATGAAGCTGGAATAGG	0.403		NaN											1	0	3.5997e-14	0.014323	3.83497e-14	23	71									
B4GALT6	9331	broad.mit.edu	37	18	29206280	29206280	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr18:29206280G>C	uc002kwz.3	-	8	1264	c.967C>G	c.(967-969)CAT>GAT	p.H323D	B4GALT6_uc010dma.2_Missense_Mutation_p.H284D|B4GALT6_uc010dmb.2_Missense_Mutation_p.H284D|B4GALT6_uc002kwy.3_RNA	NM_004775	NP_004766	Q9UBX8	B4GT6_HUMAN	beta-1,4-galactosyltransferase 6	323	Lumenal (Potential).	Manganese (By similarity).			post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi cisterna membrane|integral to membrane	metal ion binding				0			OV - Ovarian serous cystadenocarcinoma(10;0.00791)			CTATGGTGATGAGGAATTGAC	0.358		NaN											0	0	0	0.011902	0	45	15									
DYM	54808	broad.mit.edu	37	18	46904947	46904947	+	Silent	SNP	A	A	G			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr18:46904947A>G	uc002ldi.1	-	5	776	c.411T>C	c.(409-411)CCT>CCC	p.P137P	DYM_uc010xdf.1_Intron	NM_017653	NP_060123	Q7RTS9	DYM_HUMAN	dymeclin	137						Golgi apparatus					0						TGTAATTGCCAGGAGATTTTT	0.289		NaN											0	0	0	0.014323	0	24	41									
ZNF236	7776	broad.mit.edu	37	18	74606980	74606980	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr18:74606980G>A	uc002lmi.2	+	10	1621	c.1423G>A	c.(1423-1425)GAG>AAG	p.E475K	ZNF236_uc002lmj.2_RNA	NM_007345	NP_031371	Q9UL36	ZN236_HUMAN	zinc finger protein 236	475					cellular response to glucose stimulus	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)	4		Prostate(75;0.0405)|Esophageal squamous(42;0.129)|Melanoma(33;0.132)		OV - Ovarian serous cystadenocarcinoma(15;4.36e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0686)		CTCCATCCGCGAGGAGAACGG	0.657		NaN											0	0	0	0.011902	0	36	68									
ZNF236	7776	broad.mit.edu	37	18	74617282	74617282	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr18:74617282C>G	uc002lmi.2	+	13	2400	c.2202C>G	c.(2200-2202)ATC>ATG	p.I734M	ZNF236_uc002lmj.2_RNA	NM_007345	NP_031371	Q9UL36	ZN236_HUMAN	zinc finger protein 236	734	C2H2-type 16.				cellular response to glucose stimulus	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)	4		Prostate(75;0.0405)|Esophageal squamous(42;0.129)|Melanoma(33;0.132)		OV - Ovarian serous cystadenocarcinoma(15;4.36e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0686)		ACATGGGTATCCACAACGACC	0.433		NaN											0	0	0	0.006122	0	19	22									
S1PR4	8698	broad.mit.edu	37	19	3179545	3179545	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr19:3179545C>T	uc002lxg.2	+	1	780	c.755C>T	c.(754-756)ACG>ATG	p.T252M		NM_003775	NP_003766	O95977	S1PR4_HUMAN	sphingosine-1-phosphate receptor 4 precursor	252	Cytoplasmic (By similarity).				activation of phospholipase C activity|elevation of cytosolic calcium ion concentration|immune response	integral to plasma membrane	lipid binding|lysosphingolipid and lysophosphatidic acid receptor activity			lung(1)|skin(1)	2						CTGCTGAAGACGGTGCTGATG	0.687		NaN											0	0	0	0.008871	0	15	34									
HDGFRP2	84717	broad.mit.edu	37	19	4475339	4475339	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr19:4475339C>T	uc002mao.2	+	2	233	c.140C>T	c.(139-141)ACA>ATA	p.T47I	HDGFRP2_uc002map.2_Missense_Mutation_p.T47I|HDGFRP2_uc010dtz.1_5'Flank	NM_001001520	NP_001001520	Q7Z4V5	HDGR2_HUMAN	hepatoma-derived growth factor-related protein 2	47	PWWP.				transcription, DNA-dependent	nucleus	DNA binding|protein binding				0						TTCTTTGGCACACACGAAACG	0.602		NaN											0	0	0	0.006122	0	18	29									
FBN3	84467	broad.mit.edu	37	19	8193911	8193911	+	Splice_Site	SNP	C	C	T			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr19:8193911C>T	uc002mjf.2	-	17	2317	c.2296_splice	c.e17+1	p.D766_splice		NM_032447	NP_115823	Q75N90	FBN3_HUMAN	fibrillin 3 precursor							proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			ovary(6)|skin(3)|pancreas(1)|central_nervous_system(1)	11						GGACCCAGTACCTTTGCAGAT	0.592		NaN											0	0	0	0.008871	0	17	39									
ZNF700	90592	broad.mit.edu	37	19	12059541	12059541	+	Silent	SNP	C	C	T			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr19:12059541C>T	uc002msu.2	+	4	828	c.702C>T	c.(700-702)TTC>TTT	p.F234F	ZNF700_uc010xme.1_Silent_p.F252F|ZNF763_uc010xmf.1_Intron	NM_144566	NP_653167	Q9H0M5	ZN700_HUMAN	zinc finger protein 700	234	C2H2-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						TCCATTCTTTCAGTTTATATC	0.348		NaN											0	0	0	0.012319	0	22	81									
ZSWIM4	65249	broad.mit.edu	37	19	13936478	13936478	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr19:13936478C>T	uc002mxh.1	+	11	2168	c.1979C>T	c.(1978-1980)GCC>GTC	p.A660V	ZSWIM4_uc010xng.1_Missense_Mutation_p.A583V	NM_023072	NP_075560	Q9H7M6	ZSWM4_HUMAN	zinc finger, SWIM-type containing 4	660							zinc ion binding	p.A660A(1)		central_nervous_system(2)	2			OV - Ovarian serous cystadenocarcinoma(19;2.94e-23)|Epithelial(5;4.58e-19)			CCGGTCAGCGCCCCACCAGAC	0.677		NaN											0	0	0	0.013726	0	30	24									
ZNF626	199777	broad.mit.edu	37	19	20807939	20807939	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr19:20807939C>G	uc002npb.1	-	4	894	c.744G>C	c.(742-744)AAG>AAC	p.K248N	ZNF626_uc002npc.1_Missense_Mutation_p.K172N	NM_001076675	NP_001070143	Q68DY1	ZN626_HUMAN	zinc finger protein 626 isoform 1	248	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1						TATGATTTCTCTTATGTGTAG	0.383		NaN											0	0	0	0.013114	0	45	104									
APLP1	333	broad.mit.edu	37	19	36369852	36369852	+	Silent	SNP	C	C	T			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr19:36369852C>T	uc002oce.2	+	15	1846	c.1708C>T	c.(1708-1710)CTG>TTG	p.L570L	APLP1_uc010xsz.1_Silent_p.L531L|APLP1_uc002ocf.2_Silent_p.L571L|APLP1_uc002ocg.2_Silent_p.L474L|APLP1_uc010xta.1_Silent_p.L564L	NM_005166	NP_005157	P51693	APLP1_HUMAN	amyloid precursor-like protein 1 isoform 2	570	Extracellular (Potential).				apoptosis|cell adhesion|cellular response to norepinephrine stimulus|endocytosis|negative regulation of cAMP biosynthetic process|nervous system development|organ morphogenesis	basement membrane|integral to membrane|perinuclear region of cytoplasm|plasma membrane	alpha-2A adrenergic receptor binding|alpha-2B adrenergic receptor binding|alpha-2C adrenergic receptor binding|heparin binding|identical protein binding|metal ion binding			ovary(2)	2	all_lung(56;7.14e-07)|Lung NSC(56;1.12e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			GAGGGATGAGCTGGTAAGAGG	0.582		NaN											0	0	0	0.01441	0	51	23									
MEGF8	1954	broad.mit.edu	37	19	42830399	42830399	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr19:42830399G>A	uc002otl.3	+	1	639	c.4G>A	c.(4-6)GCC>ACC	p.A2T		NM_001410	NP_001401	Q7Z7M0	MEGF8_HUMAN	multiple EGF-like-domains 8	2						integral to membrane	calcium ion binding|structural molecule activity			ovary(1)	1		Prostate(69;0.00682)				GGCGGCGATGGCCCTGGGCAA	0.672		NaN									OREG0025502	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.013537	0	12	12									
PSG7	5676	broad.mit.edu	37	19	43439844	43439844	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr19:43439844C>G	uc002ovl.3	-	2	244	c.142G>C	c.(142-144)GGG>CGG	p.G48R	PSG3_uc002ouf.2_Intron|PSG11_uc002ouw.2_Intron|PSG10_uc002ouv.1_Intron|PSG6_uc002ovh.1_Intron|PSG6_uc002ovi.2_Intron|PSG6_uc010xwk.1_Intron|PSG11_uc002ovk.1_Intron|PSG7_uc010xwl.1_Intron	NM_002783	NP_002774	Q13046	PSG7_HUMAN	pregnancy specific beta-1-glycoprotein 7	48	Ig-like V-type.				female pregnancy	extracellular region					0		Prostate(69;0.00682)				ACATCCTTCCCCTCGGAAACT	0.488		NaN											0	0	0	0.01441	0	41	294									
IRGQ	126298	broad.mit.edu	37	19	44099434	44099434	+	Silent	SNP	C	C	T			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr19:44099434C>T	uc002oww.2	-	1	175	c.57G>A	c.(55-57)GGG>GGA	p.G19G	IRGQ_uc010eiv.2_Silent_p.G19G|ZNF576_uc002owy.2_5'Flank|ZNF576_uc002owz.2_5'Flank|SRRM5_uc002oxb.2_5'Flank	NM_001007561	NP_001007562	Q8WZA9	IRGQ_HUMAN	immunity-related GTPase family, Q	19							protein binding			ovary(1)|pancreas(1)	2		Prostate(69;0.0199)				GCGCGGACTTCCCCAAGCCCG	0.682		NaN											0	0	0	0.020292	0	14	48									
PVRL2	5819	broad.mit.edu	37	19	45375390	45375390	+	Silent	SNP	G	G	A			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr19:45375390G>A	uc002ozw.1	+	3	1149	c.759G>A	c.(757-759)GTG>GTA	p.V253V	PVRL2_uc002ozv.2_Silent_p.V253V	NM_001042724	NP_001036189	Q92692	PVRL2_HUMAN	poliovirus receptor related 2 isoform delta	253	Ig-like C2-type 1.|Extracellular (Potential).				adherens junction organization|adhesion to symbiont|cell junction assembly|homophilic cell adhesion|positive regulation of immunoglobulin mediated immune response|positive regulation of mast cell activation|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target|susceptibility to natural killer cell mediated cytotoxicity|susceptibility to T cell mediated cytotoxicity|viral envelope fusion with host membrane|virion attachment, binding of host cell surface coreceptor	cell surface|integral to membrane|zonula adherens	cell adhesion molecule binding|coreceptor activity|protein homodimerization activity				0	Lung NSC(12;0.00195)|all_lung(12;0.00522)	Ovarian(192;0.0728)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.0143)		TGATACCTGTGACCCTCTCTG	0.567		NaN											0	0	0	0.00499	0	17	93									
CCDC114	93233	broad.mit.edu	37	19	48800570	48800570	+	Missense_Mutation	SNP	T	T	C			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr19:48800570T>C	uc002pir.2	-	14	2359	c.1676A>G	c.(1675-1677)CAC>CGC	p.H559R	CCDC114_uc002piq.2_Missense_Mutation_p.H368R|CCDC114_uc002pio.2_3'UTR	NM_144577	NP_653178	Q96M63	CC114_HUMAN	coiled-coil domain containing 114 isoform 2	559										ovary(1)	1		all_epithelial(76;9.64e-05)|all_lung(116;0.000147)|Lung NSC(112;0.000251)|Prostate(7;0.0187)|all_neural(266;0.0228)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000134)|all cancers(93;0.000162)|Epithelial(262;0.0134)|GBM - Glioblastoma multiforme(486;0.0143)		AAAAGTGACGTGGCCAAGAGA	0.637		NaN											0	0	0	0.008871	0	18	21									
C19orf41	126123	broad.mit.edu	37	19	50666011	50666011	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr19:50666011C>A	uc002prp.1	-	2	379	c.292G>T	c.(292-294)GGT>TGT	p.G98C		NM_152358	NP_689571	Q6UXV1	IZUM2_HUMAN	hypothetical protein LOC126123 precursor	98	Extracellular (Potential).					integral to membrane					0		all_neural(266;0.0459)|Ovarian(192;0.0728)		GBM - Glioblastoma multiforme(134;0.00364)|OV - Ovarian serous cystadenocarcinoma(262;0.0052)		AGAGAGTTACCCATTAAGTGC	0.537		NaN											1	0	1.06647e-15	0.017118	1.14365e-15	31	67									
LILRB2	10288	broad.mit.edu	37	19	54782754	54782754	+	Missense_Mutation	SNP	A	A	G	rs143661416	byFrequency	TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr19:54782754A>G	uc002qfb.2	-	6	1134	c.868T>C	c.(868-870)TAC>CAC	p.Y290H	LILRA6_uc002qew.1_Intron|LILRB2_uc010eri.2_Missense_Mutation_p.Y290H|LILRB2_uc010erj.2_RNA|LILRB2_uc002qfc.2_Missense_Mutation_p.Y290H|LILRB2_uc010yet.1_Missense_Mutation_p.Y174H|LILRB2_uc010yeu.1_RNA	NM_005874	NP_005865	Q8N423	LIRB2_HUMAN	leukocyte immunoglobulin-like receptor,	290	Extracellular (Potential).|Ig-like C2-type 3.				cell surface receptor linked signaling pathway|cell-cell signaling|cellular defense response|immune response|regulation of immune response	integral to plasma membrane|membrane fraction	receptor activity			skin(1)	1	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		TGGCCCCCGTAGGAGCGGCTC	0.667		NaN											0	0	0	0.00499	0	13	52									
KIR2DL3	3804	broad.mit.edu	37	19	55263182	55263182	+	Missense_Mutation	SNP	A	A	T			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr19:55263182A>T	uc002qgv.2	+	6	815	c.797A>T	c.(796-798)CAT>CTT	p.H266L	KIR2DL3_uc002qgx.2_Missense_Mutation_p.H266L|KIR2DL3_uc002qgy.2_Missense_Mutation_p.H168L|KIR2DL3_uc010erw.1_Missense_Mutation_p.H266L|KIR2DL1_uc002qgz.1_Intron|KIR2DL3_uc002qha.1_Intron	NM_015868	NP_056952	P43628	KI2L3_HUMAN	killer cell immunoglobulin-like receptor, two	266	Cytoplasmic (Potential).				immune response|regulation of immune response	integral to plasma membrane	antigen binding|protein binding|receptor activity			ovary(2)	2				GBM - Glioblastoma multiforme(193;0.0192)		tttctccttcATCGCTGGTGC	0.438		NaN											0	0	0	0.01441	0	62	115									
SYT5	6861	broad.mit.edu	37	19	55689707	55689707	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr19:55689707G>T	uc002qjm.1	-	2	1169	c.109C>A	c.(109-111)CTG>ATG	p.L37M	SYT5_uc002qjp.2_Intron|SYT5_uc002qjn.1_Missense_Mutation_p.L37M|SYT5_uc002qjo.1_Missense_Mutation_p.L37M	NM_003180	NP_003171	O00445	SYT5_HUMAN	synaptotagmin V	37	Helical; (Potential).				energy reserve metabolic process|regulation of insulin secretion|synaptic transmission	cell junction|integral to membrane|recycling endosome membrane|synaptic vesicle membrane	metal ion binding|transporter activity				0			BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0452)		CCTGAGACCAGCACGATGGTG	0.617		NaN											1	0	2.74318e-10	0.006214	2.88476e-10	9	5									
PKDCC	91461	broad.mit.edu	37	2	42284440	42284440	+	Silent	SNP	C	C	T			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr2:42284440C>T	uc002rsg.2	+	6	1481	c.1302C>T	c.(1300-1302)CTC>CTT	p.L434L		NM_138370	NP_612379	Q504Y2	PKDCC_HUMAN	protein kinase-like protein SgK493	434	Protein kinase.				cell differentiation|embryonic digestive tract development|lung alveolus development|negative regulation of Golgi to plasma membrane protein transport|ossification|palate development|positive regulation of bone mineralization|positive regulation of chondrocyte differentiation|protein transport	Golgi apparatus	ATP binding|protein kinase activity			breast(1)	1						GGAGCTGCCTCCTTTCAGTGT	0.592		NaN											0	0	0	0.007835	0	39	119									
PPM1B	5495	broad.mit.edu	37	2	44429053	44429053	+	Missense_Mutation	SNP	A	A	G			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr2:44429053A>G	uc002rtt.2	+	2	1143	c.715A>G	c.(715-717)ATC>GTC	p.I239V	PPM1B_uc002rts.2_Missense_Mutation_p.I239V|PPM1B_uc002rtu.2_Missense_Mutation_p.I239V|PPM1B_uc002rtv.2_Intron|PPM1B_uc002rtw.2_Missense_Mutation_p.I239V|PPM1B_uc002rtx.2_Missense_Mutation_p.I239V	NM_002706	NP_002697	O75688	PPM1B_HUMAN	protein phosphatase 1B isoform 1	239					protein dephosphorylation	protein serine/threonine phosphatase complex	magnesium ion binding|manganese ion binding|protein binding|protein serine/threonine phosphatase activity			kidney(1)|skin(1)	2		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)				TGAATTTATCATCTTGGCTTG	0.408		NaN											0	0	0	0.007835	0	38	61									
SLC4A5	57835	broad.mit.edu	37	2	74474321	74474321	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr2:74474321C>T	uc002sko.1	-	14	1903	c.1901G>A	c.(1900-1902)CGC>CAC	p.R634H	SLC4A5_uc002skl.2_RNA|SLC4A5_uc002skn.2_Missense_Mutation_p.R634H|SLC4A5_uc010ffc.1_Missense_Mutation_p.R634H|SLC4A5_uc002skp.1_Missense_Mutation_p.R570H|SLC4A5_uc002sks.1_Missense_Mutation_p.R634H	NM_021196	NP_067019	Q9BY07	S4A5_HUMAN	sodium bicarbonate transporter 4 isoform a	634	Extracellular (Potential).					apical plasma membrane|integral to membrane	inorganic anion exchanger activity|sodium:bicarbonate symporter activity			ovary(5)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	9						CTCGGTGAAGCGGGTGATATA	0.488		NaN											0	0	0	0.014323	0	22	190									
MRPL35	51318	broad.mit.edu	37	2	86434368	86434368	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr2:86434368C>T	uc002srg.3	+	3	354	c.296C>T	c.(295-297)GCA>GTA	p.A99V	MRPL35_uc002srf.3_Missense_Mutation_p.A99V	NM_016622	NP_057706	Q9NZE8	RM35_HUMAN	mitochondrial ribosomal protein L35 isoform a	99					translation	mitochondrial ribosome	structural constituent of ribosome				0						TACTTCAGTGCAAGAAAAGGC	0.418		NaN											0	0	0	0.008291	0	9	60									
KIAA1310	55683	broad.mit.edu	37	2	97268530	97268530	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr2:97268530G>A	uc002swn.3	-	18	2365	c.2219C>T	c.(2218-2220)TCT>TTT	p.S740F	KIAA1310_uc002swh.3_Missense_Mutation_p.S626F|KIAA1310_uc002swi.3_Missense_Mutation_p.S667F|KIAA1310_uc002swj.3_RNA|KIAA1310_uc002swk.3_Missense_Mutation_p.S653F|KIAA1310_uc010fhz.2_Missense_Mutation_p.S560F|KIAA1310_uc002swl.3_Missense_Mutation_p.S639F|KIAA1310_uc002swm.3_RNA|KIAA1310_uc010yur.1_Missense_Mutation_p.S534F|KIAA1310_uc002swo.2_Missense_Mutation_p.S88F	NM_001115016	NP_001108488	Q9P2N6	K1310_HUMAN	hypothetical protein LOC55683 isoform a	766	Ser-rich.										0						TGGAAGGCCAGAGGTCTTGCT	0.592		NaN											0	0	0	0.00632	0	24	104									
MAP4K4	9448	broad.mit.edu	37	2	102460640	102460640	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr2:102460640C>T	uc002tbg.2	+	12	1155	c.1100C>T	c.(1099-1101)TCC>TTC	p.S367F	MAP4K4_uc002tbc.2_Missense_Mutation_p.S367F|MAP4K4_uc002tbd.2_Missense_Mutation_p.S367F|MAP4K4_uc002tbe.2_Missense_Mutation_p.S367F|MAP4K4_uc002tbf.2_Missense_Mutation_p.S367F|MAP4K4_uc010yvy.1_Missense_Mutation_p.S367F|MAP4K4_uc002tbh.2_Missense_Mutation_p.S367F|MAP4K4_uc002tbi.2_Missense_Mutation_p.S220F|MAP4K4_uc010yvz.1_Missense_Mutation_p.S347F|MAP4K4_uc002tbk.2_5'UTR|MAP4K4_uc002tbj.1_Missense_Mutation_p.S263F	NM_145687	NP_663720	O95819	M4K4_HUMAN	mitogen-activated protein kinase kinase kinase	367					intracellular protein kinase cascade|regulation of JNK cascade|response to stress	cytoplasm	ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			stomach(1)|lung(1)|central_nervous_system(1)|skin(1)	4						AAGGAACGTTCCGAGGCTCTT	0.512		NaN											0	0	0	0.014758	0	5	28									
ANAPC1	64682	broad.mit.edu	37	2	112621282	112621282	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr2:112621282G>A	uc002thi.2	-	9	1269	c.1022C>T	c.(1021-1023)TCA>TTA	p.S341L		NM_022662	NP_073153	Q9H1A4	APC1_HUMAN	anaphase promoting complex subunit 1	341					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination	anaphase-promoting complex|cytosol|nucleoplasm				skin(2)	2						AATAGAAGGTGAGCGAGAATG	0.428		NaN											0	0	0	0.007413	0	17	107									
GPR148	344561	broad.mit.edu	37	2	131487541	131487541	+	Missense_Mutation	SNP	T	T	C			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr2:131487541T>C	uc002trv.1	+	1	819	c.817T>C	c.(817-819)TAC>CAC	p.Y273H		NM_207364	NP_997247	Q8TDV2	GP148_HUMAN	G protein-coupled receptor 148	273	Helical; Name=6; (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			skin(1)	1	Colorectal(110;0.1)					GATCACATTGTACGTGAGCAC	0.582		NaN											0	0	0	0.01441	0	76	75									
FAM168B	130074	broad.mit.edu	37	2	131812980	131812980	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr2:131812980G>A	uc002tsd.2	-	5	569	c.340C>T	c.(340-342)CAC>TAC	p.H114Y		NM_001009993	NP_001009993	A1KXE4	F168B_HUMAN	hypothetical protein LOC130074	114											0						TGGATGACGTGAGGAGGTGCT	0.617		NaN											0	0	0	0.01441	0	64	69									
NCKAP5	344148	broad.mit.edu	37	2	133540922	133540922	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr2:133540922C>G	uc002ttp.2	-	14	3836	c.3462G>C	c.(3460-3462)ATG>ATC	p.M1154I	NCKAP5_uc002ttq.2_Intron	NM_207363	NP_997246	O14513	NCKP5_HUMAN	Nck-associated protein 5 isoform 1	1154							protein binding				0						GGGGAGACTTCATGAGCACTT	0.488		NaN											0	0	0	0.013726	0	34	102									
LRP1B	53353	broad.mit.edu	37	2	141245258	141245258	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr2:141245258G>C	uc002tvj.1	-	58	10143	c.9171C>G	c.(9169-9171)ATC>ATG	p.I3057M		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	3057	Extracellular (Potential).|LDL-receptor class B 28.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		CGATCCAATAGATGAATTCTT	0.308		NaN								TSP Lung(27;0.18)			0	0	0	0.021022	0	38	80									
FAP	2191	broad.mit.edu	37	2	163075644	163075644	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr2:163075644G>A	uc002ucd.2	-	8	744	c.536C>T	c.(535-537)CCA>CTA	p.P179L	FAP_uc010zct.1_Missense_Mutation_p.P154L|FAP_uc010fpd.2_Intron|FAP_uc010fpe.1_Missense_Mutation_p.P146L	NM_004460	NP_004451	Q12884	SEPR_HUMAN	fibroblast activation protein, alpha subunit	179	Extracellular (Potential).				endothelial cell migration|negative regulation of extracellular matrix disassembly|proteolysis	cell junction|integral to membrane|invadopodium membrane|lamellipodium membrane	dipeptidyl-peptidase activity|metalloendopeptidase activity|protein homodimerization activity|serine-type endopeptidase activity			ovary(3)	3						TTGAAAAGGTGGATCTCCTGG	0.328		NaN											0	0	0	0.01441	0	84	90									
IFIH1	64135	broad.mit.edu	37	2	163144789	163144789	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr2:163144789C>G	uc002uce.2	-	5	1173	c.951G>C	c.(949-951)CAG>CAC	p.Q317H		NM_022168	NP_071451	Q9BYX4	IFIH1_HUMAN	interferon induced with helicase C domain 1	317	Helicase ATP-binding.				detection of virus|innate immune response|interspecies interaction between organisms|negative regulation of type I interferon production|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|regulation of apoptosis	cytosol|nucleus	ATP binding|DNA binding|double-stranded RNA binding|helicase activity|protein binding|ribonucleoprotein binding|zinc ion binding			ovary(1)	1						CCAAGGCTGGCTGGGCAACTT	0.478		NaN											0	0	0	0.012213	0	33	86									
CHN1	1123	broad.mit.edu	37	2	175664879	175664879	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr2:175664879C>G	uc002uji.2	-	13	1875	c.1345G>C	c.(1345-1347)GAG>CAG	p.E449Q	CHN1_uc010zeq.1_Missense_Mutation_p.E423Q|CHN1_uc002ujj.2_Missense_Mutation_p.E224Q|CHN1_uc002ujg.2_Missense_Mutation_p.E324Q	NM_001822	NP_001813	P15882	CHIN_HUMAN	chimerin (chimaerin) 1 isoform a	449	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|metal ion binding|SH3/SH2 adaptor activity			ovary(2)|skin(1)	3			OV - Ovarian serous cystadenocarcinoma(117;0.226)			ATAAGCAGCTCCACCACCAGT	0.358		NaN	T	TAF15	extraskeletal myxoid chondrosarcoma								0	0	0	0.006122	0	18	25									
TTN	7273	broad.mit.edu	37	2	179412163	179412163	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr2:179412163G>A	uc010zfg.1	-	288	86710	c.86486C>T	c.(86485-86487)TCA>TTA	p.S28829L	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.S22524L|TTN_uc010zfi.1_Missense_Mutation_p.S22457L|TTN_uc010zfj.1_Missense_Mutation_p.S22332L	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	29756							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TATTGGTGCTGATTCTAGAGG	0.323		NaN											0	0	0	0.001168	0	6	23									
TTN	7273	broad.mit.edu	37	2	179462655	179462655	+	Missense_Mutation	SNP	A	A	G	rs78509062		TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr2:179462655A>G	uc010zfg.1	-	242	49762	c.49538T>C	c.(49537-49539)ATT>ACT	p.I16513T	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.I10208T|TTN_uc010zfi.1_Missense_Mutation_p.I10141T|TTN_uc010zfj.1_Missense_Mutation_p.I10016T	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	17440							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CTTCATTTCAATGACATCTGT	0.368		NaN											0	0	0	0.01441	0	50	92									
STAT1	6772	broad.mit.edu	37	2	191847160	191847160	+	Missense_Mutation	SNP	T	T	C			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr2:191847160T>C	uc002usj.2	-	18	1919	c.1531A>G	c.(1531-1533)AAA>GAA	p.K511E	STAT1_uc010fse.1_Missense_Mutation_p.K511E|STAT1_uc002usk.2_Missense_Mutation_p.K511E|STAT1_uc002usl.2_Missense_Mutation_p.K513E|STAT1_uc010fsf.1_Missense_Mutation_p.K323E	NM_007315	NP_009330	P42224	STAT1_HUMAN	signal transducer and activator of transcription	511					activation of caspase activity|I-kappaB kinase/NF-kappaB cascade|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway|tyrosine phosphorylation of STAT protein	cytosol|nucleolus|nucleoplasm	calcium ion binding|protein binding|RNA polymerase II core promoter sequence-specific DNA binding|RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity|signal transducer activity			lung(3)|breast(3)|central_nervous_system(2)|upper_aerodigestive_tract(1)|ovary(1)	10			OV - Ovarian serous cystadenocarcinoma(117;0.00434)|Epithelial(96;0.0555)|all cancers(119;0.141)		Fludarabine(DB01073)	AGACCTCTTTTGGTGACAGAA	0.403		NaN											0	0	0	0.01441	0	96	115									
C2orf60	129450	broad.mit.edu	37	2	200800710	200800710	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr2:200800710G>C	uc002uvi.3	-	7	901	c.635C>G	c.(634-636)TCC>TGC	p.S212C	C2orf60_uc002uvj.3_Missense_Mutation_p.S49C|C2orf60_uc002uvk.3_RNA|C2orf60_uc010fss.2_Missense_Mutation_p.S49C	NM_001039693	NP_001034782	A2RUC4	TYW5_HUMAN	hypothetical protein LOC129450	212	JmjC.				wybutosine biosynthetic process		iron ion binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein homodimerization activity|tRNA binding				0						TCTAGCCTTGGAAAAAAGTGG	0.333		NaN											0	0	0	0.007835	0	43	163									
MYL1	4632	broad.mit.edu	37	2	211158490	211158490	+	Silent	SNP	C	C	T			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr2:211158490C>T	uc002vec.2	-	5	642	c.513G>A	c.(511-513)CTG>CTA	p.L171L	MYL1_uc002veb.2_Silent_p.L127L	NM_079420	NP_524144	P05976	MYL1_HUMAN	fast skeletal myosin alkali light chain 1	171	EF-hand 3.				muscle filament sliding|muscle organ development	cytosol|muscle myosin complex|sarcomere	calcium ion binding|structural constituent of muscle			ovary(1)	1				Epithelial(149;0.00573)|Lung(261;0.0422)|LUSC - Lung squamous cell carcinoma(261;0.0444)|all cancers(144;0.057)		GACCTGCCATCAGGGCTTCCA	0.423		NaN											0	0	0	0.01441	0	56	243									
CPS1	1373	broad.mit.edu	37	2	211525295	211525295	+	Silent	SNP	G	G	A			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr2:211525295G>A	uc002vee.3	+	32	3975	c.3843G>A	c.(3841-3843)AAG>AAA	p.K1281K	CPS1_uc010fur.2_Silent_p.K1287K|CPS1_uc010fus.2_Silent_p.K830K	NM_001875	NP_001866	P31327	CPSM_HUMAN	carbamoyl-phosphate synthetase 1 isoform b	1281	ATP-grasp 2.				carbamoyl phosphate biosynthetic process|citrulline biosynthetic process|glutamine metabolic process|glycogen catabolic process|nitric oxide metabolic process|positive regulation of vasodilation|response to lipopolysaccharide|triglyceride catabolic process|urea cycle	mitochondrial nucleoid	ATP binding|carbamoyl-phosphate synthase (ammonia) activity			ovary(8)|central_nervous_system(3)|breast(1)|skin(1)	13				Epithelial(149;0.00697)|Lung(261;0.0521)|LUSC - Lung squamous cell carcinoma(261;0.0544)|all cancers(144;0.0843)		TGGCCACCAAGGTGATGATTG	0.403		NaN											0	0	0	0.01441	0	87	221									
ERBB4	2066	broad.mit.edu	37	2	212522499	212522499	+	Silent	SNP	G	G	A			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr2:212522499G>A	uc002veg.1	-	16	2024	c.1926C>T	c.(1924-1926)TCC>TCT	p.S642S	ERBB4_uc002veh.1_Silent_p.S642S|ERBB4_uc010zji.1_Intron|ERBB4_uc010zjj.1_Intron|ERBB4_uc010fut.1_Silent_p.S642S	NM_005235	NP_005226	Q15303	ERBB4_HUMAN	v-erb-a erythroblastic leukemia viral oncogene	642	Extracellular (Potential).				cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent|transmembrane receptor protein tyrosine kinase signaling pathway	basolateral plasma membrane|cytoplasm|integral to membrane|nucleus	ATP binding|protein binding|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			lung(21)|skin(5)|stomach(2)|breast(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	33		Renal(323;0.06)|Lung NSC(271;0.197)		UCEC - Uterine corpus endometrioid carcinoma (47;0.214)|Epithelial(149;5.86e-06)|all cancers(144;2.95e-05)|Lung(261;0.00244)|LUSC - Lung squamous cell carcinoma(224;0.00266)		GTGGTAAAGTGGAATGGCCCG	0.428		NaN								TSP Lung(8;0.080)			0	0	0	0.01441	0	45	57									
ARMC9	80210	broad.mit.edu	37	2	232156134	232156134	+	Silent	SNP	C	C	T			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr2:232156134C>T	uc002vrq.3	+	18	1807	c.1695C>T	c.(1693-1695)TTC>TTT	p.F565F	ARMC9_uc002vrp.3_Silent_p.F565F|ARMC9_uc002vrr.1_RNA	NM_025139	NP_079415	Q7Z3E5	ARMC9_HUMAN	armadillo repeat containing 9	565							binding			ovary(1)	1		Renal(207;0.0112)|all_lung(227;0.0744)|all_hematologic(139;0.0749)|Acute lymphoblastic leukemia(138;0.167)|Medulloblastoma(418;0.184)|Lung NSC(271;0.205)		Epithelial(121;1.43e-10)|LUSC - Lung squamous cell carcinoma(224;0.017)|Lung(119;0.0189)		AGATAGAATTCATCATCAAGC	0.378		NaN											0	0	0	0.01441	0	46	88									
DIS3L2	129563	broad.mit.edu	37	2	232995343	232995343	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr2:232995343G>A	uc010fxz.2	+	7	892	c.616G>A	c.(616-618)GAT>AAT	p.D206N	DIS3L2_uc002vsm.3_RNA|DIS3L2_uc002vsn.1_Missense_Mutation_p.D206N|DIS3L2_uc002vso.2_RNA	NM_152383	NP_689596	Q8IYB7	DI3L2_HUMAN	DIS3 mitotic control homolog (S.	206							exonuclease activity|ribonuclease activity|RNA binding			ovary(1)|breast(1)|central_nervous_system(1)	3		all_hematologic(139;0.00809)|Renal(207;0.0113)|Acute lymphoblastic leukemia(138;0.0195)|all_lung(227;0.0465)|Lung NSC(271;0.136)		Epithelial(121;1.6e-13)|BRCA - Breast invasive adenocarcinoma(100;0.00104)|LUSC - Lung squamous cell carcinoma(224;0.0109)|Lung(119;0.0149)		AGAGGATGGTGATGCACCGGT	0.393		NaN											0	0	0	0.010504	0	20	32									
DEFB125	245938	broad.mit.edu	37	20	76884	76884	+	Silent	SNP	G	G	C			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr20:76884G>C	uc002wcw.2	+	2	297	c.297G>C	c.(295-297)CTG>CTC	p.L99L		NM_153325	NP_697020	Q8N687	DB125_HUMAN	defensin, beta 125 preproprotein	99					defense response to bacterium	extracellular region				ovary(1)|central_nervous_system(1)|skin(1)	3		all_cancers(10;7.65e-05)|Lung NSC(37;0.0417)|all_epithelial(17;0.0676)|all_lung(30;0.0713)|Breast(17;0.231)	OV - Ovarian serous cystadenocarcinoma(29;0.156)			TGAATGATCTGATAACATTTG	0.423		NaN											0	0	0	0.01441	0	173	127									
MCM8	84515	broad.mit.edu	37	20	5935320	5935320	+	Missense_Mutation	SNP	T	T	G			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr20:5935320T>G	uc002wmi.2	+	4	697	c.320T>G	c.(319-321)ATT>AGT	p.I107S	MCM8_uc002wmj.2_Missense_Mutation_p.I107S|MCM8_uc002wmk.2_Missense_Mutation_p.I107S|MCM8_uc002wml.2_Missense_Mutation_p.I107S|MCM8_uc010gbp.2_Missense_Mutation_p.I107S	NM_032485	NP_115874	Q9UJA3	MCM8_HUMAN	minichromosome maintenance complex component 8	107					cell cycle checkpoint|DNA strand elongation involved in DNA replication|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|regulation of transcription, DNA-dependent|S phase of mitotic cell cycle|transcription, DNA-dependent	nucleoplasm	ATP binding|DNA binding|nucleoside-triphosphatase activity			skin(1)	1						ACAAGGCATATTGATTTGTAT	0.318		NaN											0	0	0	0.00499	0	16	58									
PCSK2	5126	broad.mit.edu	37	20	17446013	17446013	+	Silent	SNP	C	C	G			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr20:17446013C>G	uc002wpm.2	+	11	1565	c.1245C>G	c.(1243-1245)CTC>CTG	p.L415L	PCSK2_uc002wpl.2_Silent_p.L396L|PCSK2_uc010zrm.1_Silent_p.L380L|PCSK2_uc002wpn.2_Silent_p.L69L	NM_002594	NP_002585	P16519	NEC2_HUMAN	proprotein convertase subtilisin/kexin type 2	415	Catalytic.				enkephalin processing|insulin processing|islet amyloid polypeptide processing	extracellular space|membrane|soluble fraction|transport vesicle	serine-type endopeptidase activity			ovary(3)|central_nervous_system(2)|large_intestine(1)|pancreas(1)	7					Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	TGACTGTGCTCACCTCCAAAC	0.582		NaN											0	0	0	0.014758	0	3	24									
SSTR4	6754	broad.mit.edu	37	20	23017255	23017255	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr20:23017255C>T	uc002wsr.2	+	1	1199	c.1135C>T	c.(1135-1137)CGC>TGC	p.R379C		NM_001052	NP_001043	P31391	SSR4_HUMAN	somatostatin receptor 4	379	Cytoplasmic (Potential).				G-protein signaling, coupled to cyclic nucleotide second messenger|negative regulation of cell proliferation	integral to plasma membrane	somatostatin receptor activity			ovary(1)	1	Colorectal(13;0.0518)|Lung NSC(19;0.0542)|all_lung(19;0.118)					CGGCCGCAAGCGCATCCCCCT	0.657		NaN											0	0	0	0.008871	0	17	60									
RBM39	9584	broad.mit.edu	37	20	34295071	34295071	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr20:34295071G>C	uc002xeb.2	-	14	1622	c.1278C>G	c.(1276-1278)TTC>TTG	p.F426L	RBM39_uc002xdz.2_Missense_Mutation_p.F402L|RBM39_uc002xea.2_Missense_Mutation_p.F269L|RBM39_uc010gfn.2_Missense_Mutation_p.F269L|RBM39_uc010zvm.1_Missense_Mutation_p.F398L|RBM39_uc002xeg.2_Missense_Mutation_p.F404L|RBM39_uc002xec.2_Missense_Mutation_p.F420L|RBM39_uc002xed.2_Missense_Mutation_p.F144L|RBM39_uc002xee.2_Missense_Mutation_p.F269L|RBM39_uc002xef.2_Missense_Mutation_p.F263L|RBM39_uc010zvn.1_Missense_Mutation_p.F269L	NM_184234	NP_909122	Q14498	RBM39_HUMAN	RNA binding motif protein 39 isoform a	426	Interaction with NCOA6 (By similarity).				mRNA processing|regulation of transcription, DNA-dependent|RNA splicing|transcription, DNA-dependent	centrosome|nuclear speck	nucleotide binding|protein binding|RNA binding			ovary(1)|central_nervous_system(1)	2	all_epithelial(2;0.00295)|Lung NSC(9;0.00453)|Breast(12;0.00544)|all_lung(11;0.00676)					TAGAGAGTTGGAAACATTGTG	0.333		NaN											0	0	0	0.00499	0	14	67									
AURKA	6790	broad.mit.edu	37	20	54945601	54945601	+	Missense_Mutation	SNP	T	T	G			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr20:54945601T>G	uc002xxd.1	-	10	1535	c.969A>C	c.(967-969)TTA>TTC	p.L323F	AURKA_uc002xxe.1_Missense_Mutation_p.L323F|AURKA_uc002xxf.1_Missense_Mutation_p.L323F|AURKA_uc002xxg.1_Missense_Mutation_p.L323F|AURKA_uc002xxh.1_Missense_Mutation_p.L323F|AURKA_uc002xxi.1_Missense_Mutation_p.L323F|AURKA_uc002xxj.1_Missense_Mutation_p.L323F|AURKA_uc002xxk.1_Missense_Mutation_p.L323F|AURKA_uc010zzd.1_RNA	NM_198433	NP_940835	O14965	AURKA_HUMAN	serine/threonine protein kinase 6	323	Protein kinase.				anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|mitosis|phosphatidylinositol-mediated signaling|regulation of protein stability|spindle organization	cytosol|nucleus|perinuclear region of cytoplasm|spindle microtubule|spindle pole centrosome	ATP binding|protein kinase binding|protein serine/threonine kinase activity			lung(3)|ovary(2)|breast(1)|large_intestine(1)|skin(1)	8			Colorectal(105;0.202)			GCTTCCCAACTAAAAATTCAT	0.478		NaN											0	0	0	0.013726	0	30	88									
ZGPAT	84619	broad.mit.edu	37	20	62340259	62340259	+	Silent	SNP	G	G	A			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr20:62340259G>A	uc002ygk.2	+	2	505	c.327G>A	c.(325-327)GCG>GCA	p.A109A	ARFRP1_uc002yga.2_5'Flank|ARFRP1_uc002ygc.2_5'Flank|ARFRP1_uc002ygh.3_5'Flank|ARFRP1_uc011abf.1_5'Flank|ARFRP1_uc011abg.1_5'Flank|ARFRP1_uc002yge.2_5'Flank|ARFRP1_uc002ygd.2_5'Flank|ARFRP1_uc002ygf.2_5'Flank|ARFRP1_uc002ygg.2_5'Flank|ARFRP1_uc011abh.1_5'Flank|ZGPAT_uc002ygi.2_Silent_p.A109A|ZGPAT_uc002ygj.2_Silent_p.A109A|ZGPAT_uc010gkk.1_Intron|ZGPAT_uc010gkl.1_Silent_p.A109A|ZGPAT_uc002ygm.2_Silent_p.A109A|ZGPAT_uc002ygn.3_RNA	NM_032527	NP_115916	Q8N5A5	ZGPAT_HUMAN	zinc finger, CCCH-type with G patch domain	109					negative regulation of epidermal growth factor receptor activity|negative regulation of transcription, DNA-dependent	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0	all_cancers(38;1.13e-12)|all_epithelial(29;2.64e-14)|Lung NSC(23;4.79e-10)|all_lung(23;1.7e-09)					AAGCAGAGGCGGGGCCAGAAT	0.547		NaN											0	0	0	0.014323	0	19	37									
NCAM2	4685	broad.mit.edu	37	21	22656638	22656638	+	Missense_Mutation	SNP	A	A	G			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr21:22656638A>G	uc002yld.1	+	3	504	c.255A>G	c.(253-255)ATA>ATG	p.I85M	NCAM2_uc011acb.1_Intron|NCAM2_uc011acc.1_Missense_Mutation_p.I110M	NM_004540	NP_004531	O15394	NCAM2_HUMAN	neural cell adhesion molecule 2 precursor	85	Ig-like C2-type 1.|Extracellular (Potential).				neuron cell-cell adhesion	integral to membrane|plasma membrane				ovary(4)	4		Lung NSC(9;0.195)		all cancers(11;0.00102)|OV - Ovarian serous cystadenocarcinoma(11;0.00121)|Epithelial(23;0.00147)|Colorectal(24;0.174)		ATGCAAATATAGAAGATGCAG	0.368		NaN											0	0	0	0.01441	0	49	87									
KRTAP6-3	337968	broad.mit.edu	37	21	31964950	31964950	+	Silent	SNP	C	C	T			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr21:31964950C>T	uc002yom.2	+	1	192	c.186C>T	c.(184-186)GGC>GGT	p.G62G		NM_181605	NP_853636			keratin associated protein 6-3												0						gaggcctgggctgtggctatg	0.085		NaN											0	0	0	0.00499	0	14	27									
SFRS15	57466	broad.mit.edu	37	21	33076179	33076179	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr21:33076179G>A	uc002ypd.2	-	4	646	c.220C>T	c.(220-222)CGT>TGT	p.R74C	SFRS15_uc002ype.2_Missense_Mutation_p.R74C|SFRS15_uc010glu.2_Missense_Mutation_p.R59C|SFRS15_uc002ypf.1_5'Flank|SFRS15_uc002ypg.2_Missense_Mutation_p.R74C	NM_020706	NP_065757	O95104	SFR15_HUMAN	splicing factor, arginine/serine-rich 15 isoform	74	CID.					nucleus	nucleotide binding|RNA binding				0						AACTGATGACGAGACTGTCGC	0.353		NaN											0	0	0	0.01441	0	63	144									
BRWD1	54014	broad.mit.edu	37	21	40636481	40636481	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr21:40636481C>A	uc002yxk.1	-	17	1929	c.1790G>T	c.(1789-1791)GGA>GTA	p.G597V	BRWD1_uc010goc.1_5'UTR|BRWD1_uc002yxl.2_Missense_Mutation_p.G597V|BRWD1_uc010goe.1_RNA|BRWD1_uc010gof.1_Missense_Mutation_p.G50V|BRWD1_uc010gog.1_RNA|BRWD1_uc010goh.1_RNA|BRWD1_uc010goi.1_Missense_Mutation_p.G317V	NM_018963	NP_061836	Q9NSI6	BRWD1_HUMAN	bromodomain and WD repeat domain containing 1	597					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus				skin(3)|ovary(1)	4		Prostate(19;8.44e-08)|all_epithelial(19;0.223)				ATGAGGATTTCCATCTACATC	0.413		NaN											1	0	7.41877e-09	0.012319	7.70229e-09	11	170									
BRWD1	54014	broad.mit.edu	37	21	40636563	40636563	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr21:40636563C>T	uc002yxk.1	-	17	1847	c.1708G>A	c.(1708-1710)GAT>AAT	p.D570N	BRWD1_uc010goc.1_5'UTR|BRWD1_uc002yxl.2_Missense_Mutation_p.D570N|BRWD1_uc010goe.1_Intron|BRWD1_uc010gof.1_Missense_Mutation_p.D23N|BRWD1_uc010gog.1_RNA|BRWD1_uc010goh.1_RNA|BRWD1_uc010goi.1_Missense_Mutation_p.D290N	NM_018963	NP_061836	Q9NSI6	BRWD1_HUMAN	bromodomain and WD repeat domain containing 1	570					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus				skin(3)|ovary(1)	4		Prostate(19;8.44e-08)|all_epithelial(19;0.223)				TTATTAGAATCTCTAATAAGT	0.373		NaN											0	0	0	0.010729	0	8	83									
BRWD1	54014	broad.mit.edu	37	21	40636565	40636565	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr21:40636565C>T	uc002yxk.1	-	17	1845	c.1706G>A	c.(1705-1707)AGA>AAA	p.R569K	BRWD1_uc010goc.1_5'UTR|BRWD1_uc002yxl.2_Missense_Mutation_p.R569K|BRWD1_uc010goe.1_Intron|BRWD1_uc010gof.1_Missense_Mutation_p.R22K|BRWD1_uc010gog.1_RNA|BRWD1_uc010goh.1_RNA|BRWD1_uc010goi.1_Missense_Mutation_p.R289K	NM_018963	NP_061836	Q9NSI6	BRWD1_HUMAN	bromodomain and WD repeat domain containing 1	569					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus				skin(3)|ovary(1)	4		Prostate(19;8.44e-08)|all_epithelial(19;0.223)				ATTAGAATCTCTAATAAGTGG	0.378		NaN											0	0	0	0.008291	0	8	83									
BRWD1	54014	broad.mit.edu	37	21	40636822	40636822	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr21:40636822C>T	uc002yxk.1	-	16	1793	c.1654G>A	c.(1654-1656)GAA>AAA	p.E552K	BRWD1_uc010goc.1_5'UTR|BRWD1_uc002yxl.2_Missense_Mutation_p.E552K|BRWD1_uc010goe.1_RNA|BRWD1_uc010gof.1_Intron|BRWD1_uc010gog.1_RNA|BRWD1_uc010goh.1_RNA|BRWD1_uc010goi.1_Missense_Mutation_p.E272K	NM_018963	NP_061836	Q9NSI6	BRWD1_HUMAN	bromodomain and WD repeat domain containing 1	552	WD 8.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus				skin(3)|ovary(1)	4		Prostate(19;8.44e-08)|all_epithelial(19;0.223)				ATGACCTTTTCATATGGTTTG	0.358		NaN											0	0	0	0.010729	0	10	118									
BRWD1	54014	broad.mit.edu	37	21	40636873	40636873	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr21:40636873C>G	uc002yxk.1	-	16	1742	c.1603G>C	c.(1603-1605)GAT>CAT	p.D535H	BRWD1_uc010goc.1_5'UTR|BRWD1_uc002yxl.2_Missense_Mutation_p.D535H|BRWD1_uc010goe.1_RNA|BRWD1_uc010gof.1_Intron|BRWD1_uc010gog.1_RNA|BRWD1_uc010goh.1_RNA|BRWD1_uc010goi.1_Missense_Mutation_p.D255H	NM_018963	NP_061836	Q9NSI6	BRWD1_HUMAN	bromodomain and WD repeat domain containing 1	535	WD 8.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus				skin(3)|ovary(1)	4		Prostate(19;8.44e-08)|all_epithelial(19;0.223)				CCATGAGAATCTGTACAGGCA	0.373		NaN									OREG0003860	type=REGULATORY REGION|Gene=AK125906|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	0	0	0	0.016723	0	10	144									
SLC19A1	6573	broad.mit.edu	37	21	46945798	46945798	+	Missense_Mutation	SNP	A	A	G			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr21:46945798A>G	uc002zhl.1	-	5	1345	c.1226T>C	c.(1225-1227)ATC>ACC	p.I409T	SLC19A1_uc010gpy.1_Missense_Mutation_p.I409T|SLC19A1_uc011aft.1_Missense_Mutation_p.I369T|SLC19A1_uc002zhm.1_Missense_Mutation_p.I409T|SLC19A1_uc010gpz.1_Missense_Mutation_p.I288T	NM_194255	NP_919231	P41440	S19A1_HUMAN	solute carrier family 19 member 1	409	Helical; (Probable).				folic acid metabolic process	integral to plasma membrane|membrane fraction	folic acid binding|folic acid transporter activity|methotrexate transporter activity|reduced folate carrier activity				0				Colorectal(79;0.0569)|READ - Rectum adenocarcinoma(84;0.172)		GGTCTTGACGATGGTGGCAAA	0.577		NaN											0	0	0	0.00632	0	25	82									
P2RX6	9127	broad.mit.edu	37	22	21377871	21377871	+	Missense_Mutation	SNP	A	A	G			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr22:21377871A>G	uc010gsu.1	+	8	854	c.854A>G	c.(853-855)TAC>TGC	p.Y285C	P2RX6_uc002ztz.2_Missense_Mutation_p.Y259C|P2RX6_uc002zua.2_RNA|P2RX6_uc002zuc.1_RNA	NM_005446	NP_005437	O15547	P2RX6_HUMAN	purinergic receptor P2X6 isoform 1	285	Extracellular (Potential).				muscle contraction|protein homooligomerization	cell junction|cytoplasm|integral to plasma membrane	ATP binding|extracellular ATP-gated cation channel activity|identical protein binding|purinergic nucleotide receptor activity				0						TGGCCTCACTACTCCTTCCAG	0.607		NaN											0	0	0	0.004482	0	8	21									
RASL10A	10633	broad.mit.edu	37	22	29709953	29709953	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr22:29709953C>G	uc003aff.2	-	2	756	c.243G>C	c.(241-243)TGG>TGC	p.W81C	RASL10A_uc003afg.2_Missense_Mutation_p.W81C	NM_006477	NP_006468	Q92737	RSLAA_HUMAN	RAS-related on chromosome 22 isoform a	81	Small GTPase-like.				small GTPase mediated signal transduction	plasma membrane	GTP binding|GTPase activity				0						CCTGCAAGCTCCAGTCCTTAG	0.637		NaN											0	0	0	0.00632	0	22	41									
PKDREJ	10343	broad.mit.edu	37	22	46655856	46655856	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr22:46655856C>T	uc003bhh.2	-	1	3364	c.3364G>A	c.(3364-3366)GGT>AGT	p.G1122S		NM_006071	NP_006062	Q9NTG1	PKDRE_HUMAN	receptor for egg jelly-like protein precursor	1122	Extracellular (Potential).				acrosome reaction|neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity			breast(3)|ovary(2)	5		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00459)		GTCTTCTCACCAAGAATGCAA	0.498		NaN											0	0	0	0.006999	0	39	183									
ZBED4	9889	broad.mit.edu	37	22	50280171	50280171	+	Missense_Mutation	SNP	T	T	A			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr22:50280171T>A	uc003bix.2	+	2	3331	c.2861T>A	c.(2860-2862)CTC>CAC	p.L954H		NM_014838	NP_055653	O75132	ZBED4_HUMAN	zinc finger, BED-type containing 4	954						cytoplasm|nucleus	DNA binding|metal ion binding|protein dimerization activity			ovary(2)	2		all_cancers(38;8.58e-10)|all_epithelial(38;1.15e-08)|all_lung(38;0.000109)|Lung NSC(38;0.0018)|Breast(42;0.00191)|Ovarian(80;0.0164)|Lung SC(80;0.164)		UCEC - Uterine corpus endometrioid carcinoma (28;0.168)|BRCA - Breast invasive adenocarcinoma(115;0.2)|LUAD - Lung adenocarcinoma(64;0.247)		ATGTCCACCCTCAGCCAGGTC	0.602		NaN											0	0	0	0.010729	0	9	41									
BRPF1	7862	broad.mit.edu	37	3	9786008	9786008	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr3:9786008G>T	uc003bse.2	+	9	3117	c.2718G>T	c.(2716-2718)AAG>AAT	p.K906N	BRPF1_uc003bsf.2_Missense_Mutation_p.K912N|BRPF1_uc003bsg.2_Missense_Mutation_p.K905N|BRPF1_uc011ati.1_Intron	NM_004634	NP_004625	P55201	BRPF1_HUMAN	bromodomain and PHD finger-containing protein 1	906	Required for RUNX1 and RUNX2 transcriptional activation.				histone H3 acetylation|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|MOZ/MORF histone acetyltransferase complex|plasma membrane	DNA binding|zinc ion binding			ovary(2)|central_nervous_system(1)	3	Medulloblastoma(99;0.227)					GACCGCCCAAGAGGCCGGGCC	0.647		NaN											1	0	3.09479e-21	0.006999	3.38557e-21	39	72									
ENTPD3	956	broad.mit.edu	37	3	40464569	40464569	+	Missense_Mutation	SNP	T	T	A			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr3:40464569T>A	uc003ckd.3	+	8	1152	c.1060T>A	c.(1060-1062)TCT>ACT	p.S354T	ENTPD3_uc010hhy.2_Missense_Mutation_p.S354T|uc003cke.3_Intron	NM_001248	NP_001239	O75355	ENTP3_HUMAN	ectonucleoside triphosphate diphosphohydrolase	354	Extracellular (Potential).					integral to membrane	ATP binding|hydrolase activity			ovary(1)	1				KIRC - Kidney renal clear cell carcinoma(284;0.0605)|Kidney(284;0.0758)		AGAAACCTGTTCTTTTGATGG	0.408		NaN											0	0	0	0.01441	0	82	105									
ULK4	54986	broad.mit.edu	37	3	41841697	41841697	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr3:41841697C>T	uc003ckv.3	-	20	2138	c.1937G>A	c.(1936-1938)GGA>GAA	p.G646E	ULK4_uc003ckw.2_Missense_Mutation_p.G646E	NM_017886	NP_060356	Q96C45	ULK4_HUMAN	unc-51-like kinase 4	646							ATP binding|protein serine/threonine kinase activity				0				KIRC - Kidney renal clear cell carcinoma(284;0.214)		TCCTATTTCTCCTGTAATAAA	0.418		NaN											0	0	0	0.01441	0	109	176									
NKTR	4820	broad.mit.edu	37	3	42678913	42678913	+	Nonsense_Mutation	SNP	C	C	T			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr3:42678913C>T	uc003clo.2	+	13	1864	c.1717C>T	c.(1717-1719)CAG>TAG	p.Q573*	NKTR_uc003clm.1_Nonsense_Mutation_p.Q320*|NKTR_uc003clp.2_Nonsense_Mutation_p.Q320*|NKTR_uc011azp.1_Intron|NKTR_uc003clq.1_Nonsense_Mutation_p.Q463*|NKTR_uc003clr.1_Nonsense_Mutation_p.Q320*|NKTR_uc003cls.2_Nonsense_Mutation_p.Q273*	NM_005385	NP_005376	P30414	NKTR_HUMAN	natural killer-tumor recognition sequence	573	Arg/Ser-rich.				protein folding	membrane	cyclosporin A binding|peptidyl-prolyl cis-trans isomerase activity			ovary(2)|skin(1)	3				KIRC - Kidney renal clear cell carcinoma(284;0.24)		AACAGCTTCTCAGTTAAGTGA	0.378		NaN											0	0	0	0.01441	0	53	184									
ZNF167	55888	broad.mit.edu	37	3	44612062	44612062	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr3:44612062G>C	uc010hin.2	+	6	1848	c.1460G>C	c.(1459-1461)AGA>ACA	p.R487T	ZNF167_uc003cnh.2_RNA|ZNF167_uc003cni.2_Intron|ZNF167_uc010hio.2_Missense_Mutation_p.R336T|ZNF167_uc003cnj.2_Missense_Mutation_p.R487T|ZNF167_uc003cnk.2_Intron	NM_018651	NP_061121	Q9P0L1	ZN167_HUMAN	zinc finger protein 167 isoform 1	487	C2H2-type 4.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2				KIRC - Kidney renal clear cell carcinoma(197;0.0486)|Kidney(197;0.0609)		GACCACCAGAGAACCCATACT	0.458		NaN											0	0	0	0.009718	0	40	164									
ZNF197	10168	broad.mit.edu	37	3	44674010	44674010	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr3:44674010G>A	uc003cnm.2	+	5	894	c.688G>A	c.(688-690)GAA>AAA	p.E230K	ZNF197_uc003cnn.2_Missense_Mutation_p.E230K|ZNF197_uc003cno.2_RNA|ZNF197_uc003cnp.2_Missense_Mutation_p.E230K	NM_006991	NP_008922	O14709	ZN197_HUMAN	zinc finger protein 197 isoform 1	230	KRAB.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(3)|skin(1)	4				KIRC - Kidney renal clear cell carcinoma(197;0.0478)|Kidney(197;0.0598)		CACTTCAGAGGAATGGGCATG	0.473		NaN											0	0	0	0.016723	0	12	368									
TGM4	7047	broad.mit.edu	37	3	44945406	44945406	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr3:44945406G>A	uc003coc.3	+	9	1075	c.1002G>A	c.(1000-1002)ATG>ATA	p.M334I		NM_003241	NP_003232	P49221	TGM4_HUMAN	transglutaminase 4 (prostate)	334					peptide cross-linking|protein polyamination		acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.00963)|KIRC - Kidney renal clear cell carcinoma(197;0.0546)|Kidney(197;0.0686)	L-Glutamine(DB00130)	ATGCCTGGATGAAGCGACCGG	0.617		NaN											0	0	0	0.015359	0	30	70									
FYCO1	79443	broad.mit.edu	37	3	46006596	46006596	+	Missense_Mutation	SNP	T	T	A			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr3:46006596T>A	uc003cpb.3	-	9	3285	c.3079A>T	c.(3079-3081)AGC>TGC	p.S1027C	FYCO1_uc011bal.1_Missense_Mutation_p.S1027C	NM_024513	NP_078789	Q9BQS8	FYCO1_HUMAN	FYVE and coiled-coil domain containing 1	1027	Potential.				transport	integral to membrane	metal ion binding|protein binding			central_nervous_system(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.00147)|KIRC - Kidney renal clear cell carcinoma(197;0.0272)|Kidney(197;0.0323)		CCCCTGAGGCTCTTGCACTCT	0.562		NaN											0	0	0	0.021523	0	25	67									
KIAA2018	205717	broad.mit.edu	37	3	113380114	113380114	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr3:113380114G>A	uc003eam.2	-	7	826	c.415C>T	c.(415-417)CCT>TCT	p.P139S	KIAA2018_uc003eal.2_Missense_Mutation_p.P83S	NM_001009899	NP_001009899	Q68DE3	K2018_HUMAN	hypothetical protein LOC205717	139					regulation of transcription, DNA-dependent	membrane|nucleus	calcium ion binding|DNA binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity			skin(2)|ovary(1)	3						TGGTCACTAGGAATAACAACA	0.363		NaN											0	0	0	0.00308	0	8	208									
SR140	23350	broad.mit.edu	37	3	142747454	142747454	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr3:142747454G>C	uc003evh.1	+	16	1675	c.1576G>C	c.(1576-1578)GAG>CAG	p.E526Q	SR140_uc003evi.1_Missense_Mutation_p.E117Q|SR140_uc003evj.1_RNA|SR140_uc003evk.1_Missense_Mutation_p.E525Q|SR140_uc003evl.1_Missense_Mutation_p.E93Q	NM_001080415	NP_001073884	O15042	SR140_HUMAN	U2-associated SR140 protein	526					RNA processing	nucleus	nucleotide binding|RNA binding				0						AGCTTTTGTAGAGGAACCTAG	0.343		NaN											0	0	0	0.010818	0	29	80									
PLOD2	5352	broad.mit.edu	37	3	145806415	145806415	+	Silent	SNP	C	C	T			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr3:145806415C>T	uc003evs.1	-	9	1469	c.963G>A	c.(961-963)CTG>CTA	p.L321L	PLOD2_uc003evq.1_5'Flank|PLOD2_uc011bnm.1_Silent_p.L266L|PLOD2_uc003evr.1_Silent_p.L321L	NM_000935	NP_000926	O00469	PLOD2_HUMAN	procollagen-lysine, 2-oxoglutarate 5-dioxygenase	321					protein modification process|response to hypoxia	rough endoplasmic reticulum membrane	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-lysine 5-dioxygenase activity|protein binding			ovary(1)|skin(1)	2					Vitamin C(DB00126)	TTGGGTAATCCAGTGTCAACA	0.323		NaN											0	0	0	0.00632	0	27	56									
P2RY1	5028	broad.mit.edu	37	3	152554107	152554107	+	Missense_Mutation	SNP	T	T	C			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr3:152554107T>C	uc003ezq.2	+	1	1372	c.536T>C	c.(535-537)GTG>GCG	p.V179A		NM_002563	NP_002554	P47900	P2RY1_HUMAN	purinergic receptor P2Y1	179	Helical; Name=4; (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|platelet activation	integral to plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			lung(1)	1			LUSC - Lung squamous cell carcinoma(72;0.0628)|Lung(72;0.11)			TGGCTCATTGTGGTGGTGGCG	0.567		NaN											0	0	0	0.005524	0	36	52									
SEC62	7095	broad.mit.edu	37	3	169706098	169706098	+	Silent	SNP	C	C	T			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr3:169706098C>T	uc003fgg.2	+	7	712	c.681C>T	c.(679-681)CTC>CTT	p.L227L	SEC62_uc003fgh.2_Silent_p.L227L	NM_003262	NP_003253	Q99442	SEC62_HUMAN	translocation protein 1	227	Lumenal (Potential).				cotranslational protein targeting to membrane|transmembrane transport	aggresome|endoplasmic reticulum membrane|integral to membrane|intermediate filament cytoskeleton|rough endoplasmic reticulum	protein transporter activity|receptor activity			ovary(1)	1						TTTATTACCTCAGTGTGGGTG	0.413		NaN											0	0	0	0.01441	0	60	216									
CCDC50	152137	broad.mit.edu	37	3	191047481	191047481	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr3:191047481C>G	uc003fsw.2	+	1	608	c.18C>G	c.(16-18)ATC>ATG	p.I6M	CCDC50_uc003fsv.2_Missense_Mutation_p.I6M|UTS2D_uc003fsu.2_Intron	NM_174908	NP_777568	Q8IVM0	CCD50_HUMAN	Ymer protein short isoform	6						cytoplasm	protein binding				0	all_cancers(143;8.88e-09)|Ovarian(172;0.103)|Breast(254;0.221)		LUSC - Lung squamous cell carcinoma(58;2.42e-06)|Lung(62;2.86e-06)	GBM - Glioblastoma multiforme(46;0.000136)		AAGTCAGCATCGACCAGTCCA	0.701		NaN											0	0	0	0.001168	0	4	4									
TACC3	10460	broad.mit.edu	37	4	1725159	1725159	+	Missense_Mutation	SNP	A	A	G	rs145470576	byFrequency	TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr4:1725159A>G	uc003gdo.2	+	2	119	c.11A>G	c.(10-12)CAG>CGG	p.Q4R	TMEM129_uc003gdn.2_5'Flank|TMEM129_uc003gdm.2_5'Flank|TACC3_uc010ibz.2_Missense_Mutation_p.Q4R|TACC3_uc003gdp.2_Missense_Mutation_p.Q4R	NM_006342	NP_006333	Q9Y6A5	TACC3_HUMAN	transforming, acidic coiled-coil containing	4						centrosome				ovary(1)|central_nervous_system(1)	2		Breast(71;0.212)|all_epithelial(65;0.241)	OV - Ovarian serous cystadenocarcinoma(23;0.00765)|Epithelial(3;0.0126)			ATGAGTCTGCAGGTCTTAAAC	0.458		NaN											0	0	0	0.004672	0	3	35									
EVC	2121	broad.mit.edu	37	4	5733227	5733227	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr4:5733227G>C	uc003gil.1	+	4	644	c.460G>C	c.(460-462)GAG>CAG	p.E154Q	EVC_uc003gim.1_RNA	NM_153717	NP_714928	P57679	EVC_HUMAN	Ellis van Creveld syndrome protein	154					muscle organ development	integral to membrane				ovary(1)|skin(1)	2		Myeloproliferative disorder(84;0.117)				CCAGCCGGTAGAGGCCTCTCC	0.602		NaN											0	0	0	0.017118	0	19	27									
BOD1L	259282	broad.mit.edu	37	4	13601779	13601779	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr4:13601779C>G	uc003gmz.1	-	10	6862	c.6745G>C	c.(6745-6747)GAA>CAA	p.E2249Q	BOD1L_uc010idr.1_Missense_Mutation_p.E1586Q	NM_148894	NP_683692	Q8NFC6	BOD1L_HUMAN	biorientation of chromosomes in cell division	2249							DNA binding			ovary(5)|breast(1)	6						CCGTCTTTTTCTTCCATGACT	0.517		NaN											0	0	0	0.014323	0	22	6									
RBM47	54502	broad.mit.edu	37	4	40434800	40434800	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr4:40434800G>C	uc003gvc.2	-	6	2120	c.1410C>G	c.(1408-1410)ATC>ATG	p.I470M	RBM47_uc003gvd.2_Missense_Mutation_p.I401M|RBM47_uc003gve.2_RNA|RBM47_uc011bys.1_Missense_Mutation_p.I432M	NM_001098634	NP_001092104	A0AV96	RBM47_HUMAN	RNA binding motif protein 47 isoform a	470						nucleus	nucleotide binding|RNA binding			breast(3)	3						CCACTGTGTGGATTTTGCCAT	0.413		NaN											0	0	0	0.010729	0	11	18									
CLOCK	9575	broad.mit.edu	37	4	56336930	56336930	+	Missense_Mutation	SNP	A	A	G			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr4:56336930A>G	uc003haz.1	-	9	1318	c.392T>C	c.(391-393)ATA>ACA	p.I131T	CLOCK_uc003hba.1_Missense_Mutation_p.I131T	NM_004898	NP_004889	O15516	CLOCK_HUMAN	clock	131	PAS 1.				circadian rhythm|photoperiodism|positive regulation of transcription from RNA polymerase II promoter	cytoplasm|transcription factor complex	DNA binding|histone acetyltransferase activity|sequence-specific DNA binding transcription factor activity|signal transducer activity			central_nervous_system(2)|ovary(1)	3	Lung NSC(11;0.00335)|Glioma(25;0.08)|all_epithelial(27;0.0992)|all_neural(26;0.101)		LUSC - Lung squamous cell carcinoma(4;1.62e-07)|Lung(4;1.34e-06)|Epithelial(7;0.0107)			CACATATATTATGCTTCCATC	0.284		NaN											0	0	0	0.01441	0	52	151									
ADAMTS3	9508	broad.mit.edu	37	4	73414511	73414511	+	Missense_Mutation	SNP	G	G	A	rs145300703		TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr4:73414511G>A	uc003hgk.1	-	3	225	c.188C>T	c.(187-189)GCG>GTG	p.A63V		NM_014243	NP_055058	O15072	ATS3_HUMAN	ADAM metallopeptidase with thrombospondin type 1	63					collagen catabolic process|collagen fibril organization|proteolysis	proteinaceous extracellular matrix	heparin binding|metalloendopeptidase activity|zinc ion binding			ovary(1)|lung(1)	2			Epithelial(6;4.97e-05)|OV - Ovarian serous cystadenocarcinoma(6;5.66e-05)|all cancers(17;0.000486)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			TTTGTGACTCGCAGAAAGAGT	0.448		NaN											0	0	0	0.014323	0	23	67									
CXCL6	6372	broad.mit.edu	37	4	74702788	74702788	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr4:74702788C>G	uc003hhf.2	+	2	412	c.217C>G	c.(217-219)CCG>GCG	p.P73A	IL8_uc011cbh.1_Intron	NM_002993	NP_002984	P80162	CXCL6_HUMAN	chemokine (C-X-C motif) ligand 6 (granulocyte	73					cell-cell signaling|chemotaxis|immune response|inflammatory response|signal transduction	extracellular space	chemokine activity|heparin binding				0	Breast(15;0.00102)		all cancers(17;0.00176)|Lung(101;0.128)|LUSC - Lung squamous cell carcinoma(112;0.187)			CCCCGCAGGCCCGCAGTGCTC	0.542		NaN											0	0	0	0.010729	0	12	56									
HNRPDL	9987	broad.mit.edu	37	4	83349206	83349206	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr4:83349206C>T	uc003hmr.2	-	3	1274	c.739G>A	c.(739-741)GAA>AAA	p.E247K	ENOPH1_uc003hmv.2_5'Flank|ENOPH1_uc003hmw.2_5'Flank|ENOPH1_uc003hmx.2_5'Flank|HNRPDL_uc003hmq.2_RNA|HNRPDL_uc003hms.2_RNA|HNRPDL_uc003hmt.2_Missense_Mutation_p.E247K	NM_031372	NP_112740	O14979	HNRDL_HUMAN	heterogeneous nuclear ribonucleoprotein D-like	247	RRM 2.				regulation of transcription, DNA-dependent|RNA processing|transcription, DNA-dependent	cytoplasm|heterogeneous nuclear ribonucleoprotein complex	double-stranded DNA binding|nucleotide binding|poly(A) RNA binding|protein binding|single-stranded DNA binding			skin(1)	1		Hepatocellular(203;0.114)				TTAATTTGTTCTTCAGAAGTA	0.383		NaN											0	0	0	0.00632	0	27	88									
PDHA2	5161	broad.mit.edu	37	4	96761377	96761377	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr4:96761377C>A	uc003htr.3	+	1	139	c.76C>A	c.(76-78)CGT>AGT	p.R26S		NM_005390	NP_005381	P29803	ODPAT_HUMAN	pyruvate dehydrogenase E1 alpha 2 precursor	26					glycolysis	mitochondrial matrix	pyruvate dehydrogenase (acetyl-transferring) activity			central_nervous_system(1)	1		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;1.23e-06)	NADH(DB00157)	GGTGGCATCCCGTAACTCCTC	0.522		NaN											1	0	0.000442599	0.006214	0.000450898	10	23									
LRIT3	345193	broad.mit.edu	37	4	110788968	110788968	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr4:110788968C>T	uc003hzx.3	+	2	819	c.626C>T	c.(625-627)CCA>CTA	p.P209L	LRIT3_uc003hzw.3_Missense_Mutation_p.P71L	NM_198506	NP_940908	Q3SXY7	LRIT3_HUMAN	leucine-rich repeat, immunoglobulin-like and	209	Ig-like.					integral to membrane					0				OV - Ovarian serous cystadenocarcinoma(123;0.0011)		TGTCTGAAACCATCAGTGATG	0.512		NaN											0	0	0	0.017118	0	37	43									
SYNPO2	171024	broad.mit.edu	37	4	119952786	119952786	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr4:119952786G>C	uc003icm.3	+	4	3052	c.2856G>C	c.(2854-2856)AAG>AAC	p.K952N	SYNPO2_uc010ina.2_Missense_Mutation_p.K952N|SYNPO2_uc010inb.2_Missense_Mutation_p.K952N|SYNPO2_uc011cgh.1_Intron|SYNPO2_uc010inc.2_Missense_Mutation_p.K880N	NM_001128933	NP_001122405	Q9UMS6	SYNP2_HUMAN	synaptopodin 2 isoform b	952						nucleus|Z disc	14-3-3 protein binding|actin binding|muscle alpha-actinin binding			ovary(2)	2						AAATGGGCAAGAAAAAGGGAA	0.498		NaN											0	0	0	0.004482	0	8	40									
ANXA5	308	broad.mit.edu	37	4	122590871	122590871	+	Silent	SNP	C	C	T			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr4:122590871C>T	uc003idu.3	-	11	859	c.789G>A	c.(787-789)GGG>GGA	p.G263G	ANXA5_uc003idv.3_Silent_p.G263G|ANXA5_uc003idw.3_RNA|ANXA5_uc010inm.2_Intron|ANXA5_uc010inn.2_Silent_p.G203G|ANXA5_uc010ino.2_Silent_p.G163G	NM_001154	NP_001145	P08758	ANXA5_HUMAN	annexin 5	263	Annexin 4.				anti-apoptosis|blood coagulation|negative regulation of coagulation|signal transduction	cytoplasm	calcium ion binding|calcium-dependent phospholipid binding|phospholipase inhibitor activity			ovary(1)	1						GATCATCTGTCCCAGCTCCCT	0.393		NaN											0	0	0	0.021523	0	26	53									
FAT4	79633	broad.mit.edu	37	4	126369781	126369781	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr4:126369781C>T	uc003ifj.3	+	9	7610	c.7610C>T	c.(7609-7611)TCT>TTT	p.S2537F	FAT4_uc011cgp.1_Missense_Mutation_p.S835F|FAT4_uc003ifi.1_Missense_Mutation_p.S15F	NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	2537	Extracellular (Potential).|Cadherin 24.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18						GTGACATTTTCTGTGCATGTA	0.438		NaN											0	0	0	0.00499	0	18	45									
FAT4	79633	broad.mit.edu	37	4	126411829	126411829	+	Nonsense_Mutation	SNP	G	G	T			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr4:126411829G>T	uc003ifj.3	+	17	13852	c.13852G>T	c.(13852-13854)GAG>TAG	p.E4618*	FAT4_uc011cgp.1_Nonsense_Mutation_p.E2859*|FAT4_uc003ifi.1_Nonsense_Mutation_p.E2095*	NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	4618	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18						GCAGGAGATAGAGCACTATGA	0.478		NaN											1	0	1.37522e-17	0.007413	1.48451e-17	18	37									
OTUD4	54726	broad.mit.edu	37	4	146067508	146067508	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr4:146067508C>T	uc003ika.3	-	14	1276	c.1138G>A	c.(1138-1140)GAA>AAA	p.E380K	OTUD4_uc003ijz.3_Missense_Mutation_p.E379K	NM_001102653	NP_001096123	Q01804	OTUD4_HUMAN	OTU domain containing 4 protein isoform 3	444							protein binding			ovary(2)|breast(1)	3	all_hematologic(180;0.151)					CTGCGCTCTTCTGGGGAAAGG	0.413		NaN											0	0	0	0.00308	0	7	123									
PALLD	23022	broad.mit.edu	37	4	169602510	169602510	+	Missense_Mutation	SNP	A	A	C			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr4:169602510A>C	uc011cjx.1	+	4	1326	c.1115A>C	c.(1114-1116)GAA>GCA	p.E372A	PALLD_uc003iru.2_Missense_Mutation_p.E372A|PALLD_uc003irv.2_5'UTR	NM_016081	NP_057165	Q8WX93	PALLD_HUMAN	palladin isoform 2	372					cytoskeleton organization	actin filament|focal adhesion|lamellipodium|nucleus|ruffle|sarcomere	actin binding|muscle alpha-actinin binding			ovary(1)	1		Prostate(90;0.00996)|Renal(120;0.0203)|Melanoma(52;0.144)		GBM - Glioblastoma multiforme(119;0.204)		TCTGACAGTGAAAGTTTAGCT	0.358		NaN							Pancreatic_Cancer_Familial_Clustering_of				0	0	0	0.014758	0	5	69									
ADCY2	108	broad.mit.edu	37	5	7521004	7521004	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr5:7521004G>T	uc003jdz.1	+	3	629	c.562G>T	c.(562-564)GTC>TTC	p.V188F		NM_020546	NP_065433	Q08462	ADCY2_HUMAN	adenylate cyclase 2	188	Helical; (Potential).			VWQILANVIIFICGNLAGAY -> GLADPGQCDHFHLWEPG XTN (in Ref. 1; AAP97285).	activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	cytoplasm|dendrite|integral to membrane|plasma membrane	ATP binding|metal ion binding			ovary(5)|pancreas(1)|skin(1)	7						GGAGCACCTGGTCTGGCAGGT	0.607		NaN											1	0	2.74695e-27	0.01441	3.05634e-27	49	75									
SLC45A2	51151	broad.mit.edu	37	5	33964006	33964006	+	Silent	SNP	G	G	A			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr5:33964006G>A	uc003jid.2	-	3	770	c.678C>T	c.(676-678)CTC>CTT	p.L226L	SLC45A2_uc003jie.2_Silent_p.L226L|SLC45A2_uc003jif.3_Intron|SLC45A2_uc011coe.1_Intron	NM_016180	NP_057264	Q9UMX9	S45A2_HUMAN	membrane-associated transporter protein isoform	226	Helical; Name=6; (Potential).				melanin biosynthetic process|response to stimulus|transmembrane transport|visual perception	integral to membrane|melanosome membrane		p.L226L(1)		ovary(2)|haematopoietic_and_lymphoid_tissue(1)	3						AACACAAAGTGAGCACCAATG	0.502		NaN											0	0	0	0.008871	0	21	107									
SNX18	112574	broad.mit.edu	37	5	53839070	53839070	+	Silent	SNP	G	G	A			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr5:53839070G>A	uc003jpi.3	+	2	1873	c.1683G>A	c.(1681-1683)CAG>CAA	p.Q561Q	SNX18_uc011cqg.1_3'UTR	NM_001102575	NP_001096045	Q96RF0	SNX18_HUMAN	sorting nexin 18 isoform a	Error:Variant_position_missing_in_Q96RF0_after_alignment					cell communication|endocytosis|positive regulation of GTPase activity|protein transport	endomembrane system|endosome membrane|extrinsic to internal side of plasma membrane	phosphatidylinositol binding|protein binding				0		Lung NSC(810;3.46e-05)|Breast(144;0.102)				TGGAGGTGCAGAAGGCTGACG	0.408		NaN											0	0	0	0.008361	0	29	64									
TMEM171	134285	broad.mit.edu	37	5	72419557	72419557	+	Silent	SNP	C	C	T			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr5:72419557C>T	uc003kcm.2	+	2	561	c.357C>T	c.(355-357)TTC>TTT	p.F119F	TMEM171_uc003kcn.3_Silent_p.F119F	NM_173490	NP_775761	Q8WVE6	TM171_HUMAN	transmembrane protein 171 isoform 1	119	Helical; (Potential).					integral to membrane					0		Lung NSC(167;0.0378)|Ovarian(174;0.0908)|Prostate(461;0.165)		OV - Ovarian serous cystadenocarcinoma(47;1.87e-54)|Lung(70;0.115)		GGTTTCTGTTCTTGACAAGCG	0.587		NaN											0	0	0	0.008361	0	28	71									
HOMER1	9456	broad.mit.edu	37	5	78671855	78671855	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr5:78671855C>T	uc003kfy.2	-	9	2145	c.1042G>A	c.(1042-1044)GCC>ACC	p.A348T	HOMER1_uc010jab.2_3'UTR|HOMER1_uc010jac.2_Missense_Mutation_p.A218T|HOMER1_uc010jad.2_Missense_Mutation_p.A174T	NM_004272	NP_004263	Q86YM7	HOME1_HUMAN	homer 1	348	Potential.				activation of phospholipase C activity by metabotropic glutamate receptor signaling pathway|synaptic transmission	cell junction|integral to plasma membrane|postsynaptic density|postsynaptic membrane					0		Lung NSC(167;0.00131)|all_lung(232;0.00151)|Ovarian(174;0.0261)|Prostate(461;0.191)		OV - Ovarian serous cystadenocarcinoma(54;1.87e-44)|Epithelial(54;7.07e-41)|all cancers(79;5.5e-36)		AGTAGCTTGGCCAAGTTATCT	0.363		NaN											0	0	0	0.013537	0	13	49									
TRIM36	55521	broad.mit.edu	37	5	114466549	114466549	+	Silent	SNP	A	A	G			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr5:114466549A>G	uc003kqs.2	-	9	2081	c.1572T>C	c.(1570-1572)AAT>AAC	p.N524N	TRIM36_uc011cwc.1_Silent_p.N512N|TRIM36_uc003kqt.2_Silent_p.N369N	NM_018700	NP_061170	Q9NQ86	TRI36_HUMAN	tripartite motif-containing 36 isoform 1	524	B30.2/SPRY.					acrosomal vesicle|cytoskeleton	ligase activity|zinc ion binding			ovary(4)|lung(2)|breast(2)	8		all_cancers(142;0.00133)|all_epithelial(76;2.41e-05)|Prostate(80;0.00955)|Ovarian(225;0.0443)|Breast(839;0.195)		OV - Ovarian serous cystadenocarcinoma(64;3.62e-08)|Epithelial(69;7.69e-08)|all cancers(49;9.33e-06)		GGTGTTCATTATTATAGCCAC	0.368		NaN											0	0	0	0.010818	0	31	59									
SLC27A6	28965	broad.mit.edu	37	5	128320834	128320834	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr5:128320834G>C	uc003kuy.2	+	3	886	c.490G>C	c.(490-492)GGA>CGA	p.G164R	SLC27A6_uc003kuz.2_Missense_Mutation_p.G164R	NM_014031	NP_054750	Q9Y2P4	S27A6_HUMAN	solute carrier family 27 (fatty acid	164					long-chain fatty acid transport|transmembrane transport|very long-chain fatty acid metabolic process	integral to membrane|sarcolemma	fatty acid transporter activity|long-chain fatty acid-CoA ligase activity|nucleotide binding				0		all_cancers(142;0.0483)|Prostate(80;0.055)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	Epithelial(69;0.171)|OV - Ovarian serous cystadenocarcinoma(64;0.186)		AGATTTGCTTGGAACGGTAGA	0.373		NaN											0	0	0	0.008291	0	10	21									
H2AFY	9555	broad.mit.edu	37	5	134679035	134679035	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr5:134679035G>C	uc003lam.1	-	8	1078	c.868C>G	c.(868-870)CTG>GTG	p.L290V	uc003laj.1_RNA|H2AFY_uc003lal.1_RNA|H2AFY_uc003lao.1_Missense_Mutation_p.L289V|H2AFY_uc003lan.1_Missense_Mutation_p.L287V|H2AFY_uc003lap.1_RNA|H2AFY_uc003laq.1_RNA|H2AFY_uc003lar.1_RNA|H2AFY_uc011cxz.1_Missense_Mutation_p.L118V|H2AFY_uc003las.1_Missense_Mutation_p.L290V|H2AFY_uc003lat.1_Missense_Mutation_p.L289V	NM_138610	NP_613258	O75367	H2AY_HUMAN	H2A histone family, member Y isoform 3	290	Macro.				chromatin modification|dosage compensation|nucleosome assembly	Barr body|nucleosome	DNA binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			GTCTTTTCCAGAAGTTCTTCA	0.522		NaN											0	0	0	0.00874	0	44	122									
LECT2	3950	broad.mit.edu	37	5	135283149	135283149	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr5:135283149C>G	uc003lbe.1	-	4	528	c.327G>C	c.(325-327)AAG>AAC	p.K109N	FBXL21_uc003lbc.2_Intron	NM_002302	NP_002293	O14960	LECT2_HUMAN	leukocyte cell-derived chemotaxin 2 precursor	109					chemotaxis|skeletal system development	cytoplasm|extracellular space				ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			GACCTTTATACTTAATTGGCT	0.299		NaN											0	0	0	0.012213	0	34	45									
PCDHB8	56128	broad.mit.edu	37	5	140559901	140559901	+	Silent	SNP	G	G	A			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr5:140559901G>A	uc011dai.1	+	1	2472	c.2286G>A	c.(2284-2286)ACG>ACA	p.T762T	PCDHB16_uc003liv.2_5'Flank|PCDHB16_uc010jfw.1_5'Flank	NM_019120	NP_061993	Q9UN66	PCDB8_HUMAN	protocadherin beta 8 precursor	762	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			skin(4)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GCTCAGGGACGAATGAGTTCC	0.517		NaN											0	0	0	0.008361	0	30	59									
PDGFRB	5159	broad.mit.edu	37	5	149505034	149505034	+	Missense_Mutation	SNP	T	T	C			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr5:149505034T>C	uc003lro.2	-	12	2250	c.1781A>G	c.(1780-1782)GAG>GGG	p.E594G	PDGFRB_uc010jhd.2_Missense_Mutation_p.E433G	NM_002609	NP_002600	P09619	PGFRB_HUMAN	platelet-derived growth factor receptor beta	594	Cytoplasmic (Potential).				aorta morphogenesis|cardiac myofibril assembly|hemopoiesis|metanephric glomerular capillary formation|metanephric glomerular mesangial cell proliferation involved in metanephros development|peptidyl-tyrosine phosphorylation|positive regulation of calcium ion import|positive regulation of chemotaxis|positive regulation of DNA biosynthetic process|positive regulation of ERK1 and ERK2 cascade|positive regulation of MAP kinase activity|positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway|positive regulation of mitosis|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of reactive oxygen species metabolic process|positive regulation of smooth muscle cell migration|positive regulation of smooth muscle cell proliferation|protein autophosphorylation|regulation of actin cytoskeleton organization|retina vasculature development in camera-type eye|smooth muscle cell chemotaxis	apical plasma membrane|cytoplasm|integral to plasma membrane|nucleus	ATP binding|platelet activating factor receptor activity|platelet-derived growth factor beta-receptor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|vascular endothelial growth factor receptor activity			central_nervous_system(4)|lung(4)|breast(3)|stomach(2)|prostate(2)|large_intestine(1)|ovary(1)	17		all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)		Becaplermin(DB00102)|Dasatinib(DB01254)|Imatinib(DB00619)|Sorafenib(DB00398)|Sunitinib(DB01268)	CCGCGGCAGCTCCCACGTGGA	0.403		NaN	T	ETV6|TRIP11|HIP1|RAB5EP|H4|NIN|HCMOGT-1|PDE4DIP	MPD|AML|CMML|CML								0	0	0	0.003163	0	12	11									
SH3PXD2B	285590	broad.mit.edu	37	5	171766782	171766782	+	Missense_Mutation	SNP	C	C	T	rs138949033		TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr5:171766782C>T	uc003mbr.2	-	13	1498	c.1327G>A	c.(1327-1329)GAG>AAG	p.E443K		NM_001017995	NP_001017995	A1X283	SPD2B_HUMAN	SH3 and PX domains 2B	443					adipose tissue development|bone development|cell communication|cell differentiation|eye development|heart development|podosome assembly	cell junction|cell projection|cytoplasm|podosome	phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-5-phosphate binding|SH2 domain binding			ovary(3)|skin(1)	4	Renal(175;0.000159)|Lung NSC(126;0.011)|all_lung(126;0.0175)	Medulloblastoma(196;0.0207)|all_neural(177;0.0625)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			TGGGTCACCTCGTGGGGCAGG	0.647		NaN											0	0	0	0.00499	0	16	18									
STC2	8614	broad.mit.edu	37	5	172750298	172750298	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr5:172750298C>T	uc003mco.1	-	3	1740	c.430G>A	c.(430-432)GAC>AAC	p.D144N	STC2_uc003mcn.1_Missense_Mutation_p.D59N	NM_003714	NP_003705	O76061	STC2_HUMAN	stanniocalcin 2 precursor	144					cell surface receptor linked signaling pathway|cell-cell signaling	extracellular region	hormone activity			skin(2)|ovary(1)	3	Renal(175;0.000159)|Lung NSC(126;0.00229)|all_lung(126;0.004)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)|Ovarian(839;0.223)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000183)			GCGCACAGGTCGTGCTTGAGG	0.622		NaN											0	0	0	0.006122	0	17	24									
CDYL	9425	broad.mit.edu	37	6	4937844	4937844	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr6:4937844G>A	uc003mwi.2	+	6	1287	c.1156G>A	c.(1156-1158)GAC>AAC	p.D386N	CDYL_uc003mwj.2_Missense_Mutation_p.D332N|CDYL_uc003mwk.2_Missense_Mutation_p.D97N|CDYL_uc011dhx.1_Missense_Mutation_p.D200N|CDYL_uc011dhy.1_Missense_Mutation_p.D200N	NM_001143971	NP_001137443	Q9Y232	CDYL1_HUMAN	chromodomain protein, Y chromosome-like isoform	386					regulation of transcription, DNA-dependent|spermatogenesis|transcription, DNA-dependent	nucleus	histone acetyltransferase activity				0	Ovarian(93;0.11)	all_hematologic(90;0.0901)|Lung NSC(90;0.244)		OV - Ovarian serous cystadenocarcinoma(45;0.182)		CGCTGCCGATGACAGCAAGCT	0.448		NaN											0	0	0	0.010729	0	10	26									
KDM1B	221656	broad.mit.edu	37	6	18212790	18212790	+	Silent	SNP	G	G	A			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr6:18212790G>A	uc003nco.1	+	11	1404	c.1329G>A	c.(1327-1329)AAG>AAA	p.K443K	KDM1B_uc003ncn.1_Silent_p.K414K|KDM1B_uc003ncp.1_5'UTR|KDM1B_uc003ncq.1_5'UTR	NM_153042	NP_694587	Q8NB78	KDM1B_HUMAN	amine oxidase (flavin containing) domain 1	646					multicellular organismal development|regulation of DNA methylation|regulation of gene expression by genetic imprinting|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	histone demethylase activity (H3-dimethyl-K4 specific)|histone demethylase activity (H3-monomethyl-K4 specific)|oxidoreductase activity|zinc ion binding			skin(1)	1						TGTCAGAGAAGAAGATGAAGG	0.398		NaN											0	0	0	0.01441	0	113	683									
HIST1H1B	3009	broad.mit.edu	37	6	27834978	27834978	+	Silent	SNP	G	G	C			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr6:27834978G>C	uc003njx.2	-	1	382	c.330C>G	c.(328-330)CTC>CTG	p.L110L		NM_005322	NP_005313	P16401	H15_HUMAN	histone cluster 1, H1b	110	H15.				nucleosome assembly	nucleosome|nucleus	DNA binding			large_intestine(2)|lung(1)	3						CCTTCTTGTTGAGTTTAAAGG	0.587		NaN											0	0	0	0.01441	0	49	187									
TRIM27	5987	broad.mit.edu	37	6	28889686	28889686	+	Missense_Mutation	SNP	C	C	T	rs112674133		TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr6:28889686C>T	uc003nlr.2	-	2	858	c.499G>A	c.(499-501)GCA>ACA	p.A167T	TRIM27_uc003nls.2_Missense_Mutation_p.A167T|TRIM27_uc003nlt.1_Missense_Mutation_p.A167T	NM_006510	NP_006501	P14373	TRI27_HUMAN	ret finger protein	167	Potential.				cell proliferation|negative regulation of gene expression, epigenetic|negative regulation of transcription from RNA polymerase II promoter|protein trimerization|spermatogenesis|transcription, DNA-dependent	cytoplasm|integral to plasma membrane|membrane fraction|nuclear membrane|PML body	DNA binding|protein binding|transmembrane receptor protein tyrosine kinase activity|zinc ion binding			ovary(1)	1						TCAGCTCGTGCCTGTTCCCCC	0.468		NaN	T	RET	papillary thyroid								0	0	0	0.005524	0	35	166									
MDC1	9656	broad.mit.edu	37	6	30672275	30672275	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr6:30672275C>T	uc003nrg.3	-	10	5125	c.4685G>A	c.(4684-4686)AGG>AAG	p.R1562K	MDC1_uc003nrf.3_Intron|MDC1_uc011dmp.1_Missense_Mutation_p.R1169K	NM_014641	NP_055456	Q14676	MDC1_HUMAN	mediator of DNA-damage checkpoint 1	1562	Interaction with the PRKDC complex.				cell cycle|double-strand break repair via homologous recombination|intra-S DNA damage checkpoint	focal adhesion|nucleoplasm	FHA domain binding|protein C-terminus binding			breast(2)|ovary(1)|kidney(1)	4						GACAGAGGACCTATTTGTCCT	0.592		NaN						Other_conserved_DNA_damage_response_genes					0	0	0	0.01441	0	138	102									
FOXP4	116113	broad.mit.edu	37	6	41533702	41533702	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr6:41533702G>C	uc003oql.2	+	2	662	c.204G>C	c.(202-204)CAG>CAC	p.Q68H	FOXP4_uc003oqm.2_Missense_Mutation_p.Q68H|FOXP4_uc003oqn.2_Missense_Mutation_p.Q68H	NM_001012426	NP_001012426	Q8IVH2	FOXP4_HUMAN	forkhead box P4 isoform 1	68	Gln-rich.				embryonic foregut morphogenesis|heart development|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|tissue development	cytoplasm|transcription factor complex	chromatin binding|DNA bending activity|double-stranded DNA binding|promoter binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|zinc ion binding			breast(1)	1	Ovarian(28;0.0327)|Colorectal(47;0.196)					AGCAGCAACAGGTAGGAACTG	0.617		NaN											0	0	0	0.013537	0	10	31									
LGSN	51557	broad.mit.edu	37	6	63990752	63990752	+	Missense_Mutation	SNP	T	T	C			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr6:63990752T>C	uc003peh.2	-	4	738	c.704A>G	c.(703-705)CAT>CGT	p.H235R	LGSN_uc003pei.2_Intron	NM_016571	NP_057655	Q5TDP6	LGSN_HUMAN	lengsin, lens protein with glutamine synthetase	235					glutamine biosynthetic process		glutamate-ammonia ligase activity			skin(2)	2					L-Glutamic Acid(DB00142)	GGGCTGATCATGGTTATTTAA	0.388		NaN											0	0	0	0.01441	0	62	62									
COL19A1	1310	broad.mit.edu	37	6	70778319	70778319	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr6:70778319C>T	uc003pfc.1	+	15	1292	c.1175C>T	c.(1174-1176)TCC>TTC	p.S392F	COL19A1_uc010kam.1_Missense_Mutation_p.S288F	NM_001858	NP_001849	Q14993	COJA1_HUMAN	alpha 1 type XIX collagen precursor	392	Triple-helical region 2 (COL2).				cell differentiation|cell-cell adhesion|extracellular matrix organization|skeletal system development	collagen	extracellular matrix structural constituent|protein binding, bridging			ovary(2)|breast(2)	4						TCATAGGGTTCCCTGGGGATA	0.408		NaN											0	0	0	0.014323	0	20	143									
CASP8AP2	9994	broad.mit.edu	37	6	90572752	90572752	+	Missense_Mutation	SNP	A	A	G			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr6:90572752A>G	uc003pnr.2	+	7	1520	c.1324A>G	c.(1324-1326)ACT>GCT	p.T442A	CASP8AP2_uc003pns.2_Intron|CASP8AP2_uc003pnt.2_Missense_Mutation_p.T442A|CASP8AP2_uc011dzz.1_Missense_Mutation_p.T442A	NM_001137667	NP_001131139	Q9UKL3	C8AP2_HUMAN	caspase 8 associated protein 2	442					cell cycle|cellular response to mechanical stimulus|induction of apoptosis via death domain receptors|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	cytoplasm|nucleus	caspase activator activity|death receptor binding|transcription corepressor activity			ovary(2)	2		all_cancers(76;3.64e-09)|Prostate(29;1.16e-10)|Acute lymphoblastic leukemia(125;1.45e-10)|all_hematologic(105;7.74e-07)|all_epithelial(107;4.69e-05)|Lung NSC(302;0.238)		BRCA - Breast invasive adenocarcinoma(108;0.0953)		AAACAGTAGAACTCACAAAAA	0.368		NaN											0	0	0	0.01441	0	95	77									
CASP8AP2	9994	broad.mit.edu	37	6	90581033	90581033	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr6:90581033G>C	uc003pnr.2	+	9	6014	c.5818G>C	c.(5818-5820)GAG>CAG	p.E1940Q	CASP8AP2_uc003pns.2_Missense_Mutation_p.E148Q|CASP8AP2_uc003pnt.2_Missense_Mutation_p.E1940Q|CASP8AP2_uc011dzz.1_Missense_Mutation_p.E1940Q	NM_001137667	NP_001131139	Q9UKL3	C8AP2_HUMAN	caspase 8 associated protein 2	1940	NCOA2-binding.				cell cycle|cellular response to mechanical stimulus|induction of apoptosis via death domain receptors|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	cytoplasm|nucleus	caspase activator activity|death receptor binding|transcription corepressor activity			ovary(2)	2		all_cancers(76;3.64e-09)|Prostate(29;1.16e-10)|Acute lymphoblastic leukemia(125;1.45e-10)|all_hematologic(105;7.74e-07)|all_epithelial(107;4.69e-05)|Lung NSC(302;0.238)		BRCA - Breast invasive adenocarcinoma(108;0.0953)		AATTTTATTGGAGTGTCAGAA	0.338		NaN											0	0	0	0.010771	0	38	39									
STX11	8676	broad.mit.edu	37	6	144508325	144508325	+	Silent	SNP	C	C	T			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr6:144508325C>T	uc003qks.3	+	2	753	c.561C>T	c.(559-561)GAC>GAT	p.D187D		NM_003764	NP_003755	O75558	STX11_HUMAN	syntaxin 11	187					cellular membrane fusion|intracellular protein transport|vesicle-mediated transport	Golgi apparatus|membrane	SNAP receptor activity			ovary(1)|central_nervous_system(1)	2				OV - Ovarian serous cystadenocarcinoma(155;2.17e-06)|GBM - Glioblastoma multiforme(68;0.0492)		GTAAGTGGGACGTGTTTTCCG	0.637		NaN							Familial_Hemophagocytic_Lymphohistiocytosis				0	0	0	0.004007	0	16	49									
UTRN	7402	broad.mit.edu	37	6	144820449	144820449	+	Silent	SNP	G	G	A			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr6:144820449G>A	uc003qkt.2	+	33	4742	c.4650G>A	c.(4648-4650)AAG>AAA	p.K1550K		NM_007124	NP_009055	P46939	UTRO_HUMAN	utrophin	1550	Interaction with SYNM.|Spectrin 11.				muscle contraction|muscle organ development|positive regulation of cell-matrix adhesion	cell junction|cytoplasm|cytoskeleton|membrane fraction|nucleus|postsynaptic membrane	actin binding|calcium ion binding|zinc ion binding			ovary(4)|pancreas(1)	5		Ovarian(120;0.218)		OV - Ovarian serous cystadenocarcinoma(155;5.72e-07)|GBM - Glioblastoma multiforme(68;4.9e-05)|Colorectal(48;0.213)		GGAAAATGAAGAAAGAGGCTG	0.478		NaN											0	0	0	0.020292	0	14	60									
ACTB	60	broad.mit.edu	37	7	5567464	5567464	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr7:5567464G>A	uc003sos.3	-	5	1079	c.1043C>T	c.(1042-1044)TCG>TTG	p.S348L	ACTB_uc003sor.3_Missense_Mutation_p.S226L|ACTB_uc003sot.3_Missense_Mutation_p.S348L|ACTB_uc003soq.3_Missense_Mutation_p.S226L|ACTB_uc010ksy.2_Missense_Mutation_p.S226L	NM_001101	NP_001092	P60709	ACTB_HUMAN	beta actin	348					'de novo' posttranslational protein folding|adherens junction organization|axon guidance|blood coagulation|cell junction assembly|cellular component movement	cytoskeleton|cytosol|MLL5-L complex|NuA4 histone acetyltransferase complex|ribonucleoprotein complex	ATP binding|kinesin binding|nitric-oxide synthase binding|structural constituent of cytoskeleton				0		Ovarian(82;0.0606)		UCEC - Uterine corpus endometrioid carcinoma (126;0.175)|OV - Ovarian serous cystadenocarcinoma(56;4.24e-37)		GGTGGACAGCGAGGCCAGGAT	0.587		NaN											0	0	0	0.008871	0	17	104									
ZNF716	441234	broad.mit.edu	37	7	57528875	57528875	+	Silent	SNP	T	T	C			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr7:57528875T>C	uc011kdi.1	+	4	820	c.708T>C	c.(706-708)ACT>ACC	p.T236T		NM_001159279	NP_001152751			zinc finger protein 716											ovary(2)	2						GAATTCATACTGGAGAGAAAC	0.378		NaN											0	0	0	0.014758	0	5	28									
SEMA3D	223117	broad.mit.edu	37	7	84671572	84671572	+	Missense_Mutation	SNP	T	T	C			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr7:84671572T>C	uc003uic.2	-	8	931	c.891A>G	c.(889-891)ATA>ATG	p.I297M	SEMA3D_uc010led.2_Missense_Mutation_p.I297M|SEMA3D_uc003uib.2_5'Flank	NM_152754	NP_689967	O95025	SEM3D_HUMAN	semaphorin 3D precursor	297	Sema.				cell differentiation|nervous system development	extracellular region|membrane	receptor activity			ovary(3)|large_intestine(2)	5						TCCACTTGTTTATCAGGCTGC	0.378		NaN											0	0	0	0.01441	0	193	306									
C7orf43	55262	broad.mit.edu	37	7	99753312	99753312	+	Silent	SNP	C	C	G			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr7:99753312C>G	uc003utr.2	-	9	1557	c.1377G>C	c.(1375-1377)CTG>CTC	p.L459L	C7orf43_uc010lgo.2_Silent_p.L85L|C7orf43_uc010lgp.2_Silent_p.L81L|C7orf43_uc011kjj.1_Silent_p.L227L|C7orf43_uc003uts.2_Silent_p.L190L	NM_018275	NP_060745	Q8WVR3	CG043_HUMAN	hypothetical protein LOC55262	459											0	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					GCCCCGTCCTCAGAGCCTGGA	0.637		NaN											0	0	0	0.01441	0	77	116									
C7orf51	222950	broad.mit.edu	37	7	100087130	100087130	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr7:100087130G>T	uc003uvd.1	+	4	1945	c.1786G>T	c.(1786-1788)GAT>TAT	p.D596Y	C7orf51_uc003uve.1_Missense_Mutation_p.D378Y	NM_173564	NP_775835	Q6ZVC0	CG051_HUMAN	hypothetical protein FLJ37538	596										skin(1)	1	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					GCAAGGGACCGATGGGGGTGC	0.637		NaN											1	0	9.8876e-21	0.021022	1.07805e-20	34	71									
C7orf58	79974	broad.mit.edu	37	7	120770316	120770316	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr7:120770316G>A	uc003vjq.3	+	12	1992	c.1545G>A	c.(1543-1545)ATG>ATA	p.M515I	C7orf58_uc003vjr.1_Missense_Mutation_p.M515I|C7orf58_uc003vjs.3_Missense_Mutation_p.M515I|C7orf58_uc003vjt.3_Missense_Mutation_p.M295I|C7orf58_uc010lkk.1_Missense_Mutation_p.M295I	NM_024913	NP_079189	A4D0V7	CG058_HUMAN	hypothetical protein LOC79974 isoform 1	515						endoplasmic reticulum				ovary(4)|large_intestine(2)|skin(2)|pancreas(1)	9	all_neural(327;0.117)					TTCAGTTCATGAATAAAAAGA	0.358		NaN											0	0	0	0.01441	0	48	74									
LRRC4	64101	broad.mit.edu	37	7	127670603	127670603	+	Silent	SNP	G	G	A			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr7:127670603G>A	uc003vmk.2	-	2	228	c.91C>T	c.(91-93)CTG>TTG	p.L31L	SND1_uc003vmi.2_Intron|SND1_uc010lle.2_Intron	NM_022143	NP_071426	Q9HBW1	LRRC4_HUMAN	leucine rich repeat containing 4 precursor	31						cell junction|integral to membrane|postsynaptic membrane				large_intestine(1)|breast(1)|central_nervous_system(1)|pancreas(1)	4				Lung(243;0.124)		GCTGCACACAGAATCCACACT	0.622		NaN											0	0	0	0.01441	0	59	79									
FAM71F1	84691	broad.mit.edu	37	7	128355645	128355645	+	Silent	SNP	G	G	T			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr7:128355645G>T	uc003vno.1	+	1	203	c.150G>T	c.(148-150)GCG>GCT	p.A50A	FAM71F1_uc010llo.1_Intron|FAM71F1_uc011koq.1_Intron|FAM71F1_uc003vnm.1_Intron|FAM71F1_uc003vnn.1_Intron|FAM71F1_uc010llp.1_RNA|FAM71F1_uc003vnp.1_Silent_p.A50A	NM_032599	NP_115988	Q96KD3	F71F1_HUMAN	testes development-related NYD-SP18	50										skin(1)	1						ACCCTGGAGCGGGCCTAGGTG	0.537		NaN											1	0	2.44813e-32	0.01441	2.75204e-32	59	85									
INSIG1	3638	broad.mit.edu	37	7	155093959	155093959	+	Splice_Site	SNP	A	A	C			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr7:155093959A>C	uc003wly.2	+	4	749	c.538_splice	c.e4-2	p.K180_splice	INSIG1_uc011kvu.1_Splice_Site_p.K28_splice|INSIG1_uc003wlz.2_Intron	NM_005542	NP_005533	O15503	INSI1_HUMAN	insulin induced gene 1 isoform 1						cell proliferation|ER-nuclear sterol response pathway	endoplasmic reticulum membrane|integral to membrane	protein binding				0	all_neural(206;0.119)	all_hematologic(28;0.0592)	OV - Ovarian serous cystadenocarcinoma(82;0.011)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		TTATATCACCAGAAATTGGAT	0.378		NaN											0	0	0	0.01441	0	58	87									
PNOC	5368	broad.mit.edu	37	8	28196662	28196662	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr8:28196662G>C	uc010lva.2	+	3	440	c.232G>C	c.(232-234)GAG>CAG	p.E78Q	PNOC_uc003xgp.2_Missense_Mutation_p.E78Q|PNOC_uc011lau.1_Missense_Mutation_p.E14Q	NM_006228	NP_006219	Q13519	PNOC_HUMAN	prepronociceptin precursor	78					neuropeptide signaling pathway|sensory perception|synaptic transmission	extracellular region	neuropeptide hormone activity|opioid peptide activity			central_nervous_system(1)	1		Ovarian(32;0.000953)		KIRC - Kidney renal clear cell carcinoma(542;0.104)|Kidney(114;0.125)|Colorectal(74;0.145)|BRCA - Breast invasive adenocarcinoma(99;0.245)		TGCCGCCCCAGAGCATGTGGC	0.632		NaN											0	0	0	0.016723	0	11	5									
TEX15	56154	broad.mit.edu	37	8	30702296	30702296	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr8:30702296G>T	uc003xil.2	-	1	4238	c.4238C>A	c.(4237-4239)GCA>GAA	p.A1413E		NM_031271	NP_112561	Q9BXT5	TEX15_HUMAN	testis expressed 15	1413										ovary(3)|upper_aerodigestive_tract(2)|skin(2)	7				KIRC - Kidney renal clear cell carcinoma(542;0.0918)|Kidney(114;0.111)		AGTTCCTGATGCTACATCCAA	0.363		NaN											1	0	1.06522e-23	0.013114	1.17716e-23	42	43									
UNC5D	137970	broad.mit.edu	37	8	35584024	35584024	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr8:35584024G>T	uc003xjr.1	+	10	1986	c.1658G>T	c.(1657-1659)GGG>GTG	p.G553V	UNC5D_uc003xjs.1_Missense_Mutation_p.G548V|UNC5D_uc003xju.1_Missense_Mutation_p.G129V|UNC5D_uc003xjt.1_Missense_Mutation_p.G311V	NM_080872	NP_543148	Q6UXZ4	UNC5D_HUMAN	unc-5 homolog D precursor	553	ZU5.|Cytoplasmic (Potential).				apoptosis|axon guidance	integral to membrane	receptor activity			upper_aerodigestive_tract(2)|ovary(2)|pancreas(1)|skin(1)	6				READ - Rectum adenocarcinoma(1;1.31e-05)|Colorectal(1;0.000723)		CATTTAGGGGGGCGCTTAGTA	0.413		NaN											1	0	6.4771e-29	0.010771	7.23128e-29	41	42									
KCNU1	157855	broad.mit.edu	37	8	36662755	36662755	+	Silent	SNP	T	T	C			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr8:36662755T>C	uc010lvw.2	+	4	507	c.420T>C	c.(418-420)CCT>CCC	p.P140P	KCNU1_uc003xjw.2_RNA	NM_001031836	NP_001027006	A8MYU2	KCNU1_HUMAN	potassium channel, subfamily U, member 1	140	Helical; Name=Segment S2; (Potential).					voltage-gated potassium channel complex	binding|large conductance calcium-activated potassium channel activity|voltage-gated potassium channel activity			ovary(1)	1				KIRC - Kidney renal clear cell carcinoma(67;0.0504)|Kidney(114;0.0634)		AAACCATTCCTATTGATTTGG	0.363		NaN											0	0	0	0.00308	0	7	5									
ADAM2	2515	broad.mit.edu	37	8	39607251	39607251	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr8:39607251G>C	uc003xnj.2	-	17	1885	c.1810C>G	c.(1810-1812)CAA>GAA	p.Q604E	ADAM2_uc003xnk.2_Missense_Mutation_p.Q585E|ADAM2_uc011lck.1_Missense_Mutation_p.Q541E|ADAM2_uc003xnl.2_Missense_Mutation_p.Q448E	NM_001464	NP_001455	Q99965	ADAM2_HUMAN	ADAM metallopeptidase domain 2 proprotein	604	Extracellular (Potential).|Cys-rich.				cell adhesion|fusion of sperm to egg plasma membrane|proteolysis	integral to plasma membrane	integrin binding|metalloendopeptidase activity|zinc ion binding			ovary(1)|lung(1)	2		all_cancers(7;2.38e-28)|all_epithelial(6;8.85e-21)|all_lung(54;1.24e-07)|Lung NSC(58;1.94e-07)|Hepatocellular(245;0.00745)|Breast(189;0.00908)|Renal(179;0.0183)|Colorectal(162;0.246)	LUSC - Lung squamous cell carcinoma(45;0.000149)	READ - Rectum adenocarcinoma(644;0.0689)|Kidney(114;0.162)		ACACATCTTTGATTCCTGCAA	0.343		NaN											0	0	0	0.007835	0	38	94									
CHD7	55636	broad.mit.edu	37	8	61653990	61653990	+	Translation_Start_Site	SNP	A	A	T			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08			A	T	A	A		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr8:61653990A>T	uc003xue.2	+	2	476	c.-1A>T	c.(-3-1)GAAGA>GATGA			NM_017780	NP_060250	Q9P2D1	CHD7_HUMAN	chromodomain helicase DNA binding protein 7						central nervous system development|chromatin modification|cognition|cranial nerve development|face development|heart morphogenesis|in utero embryonic development|inner ear morphogenesis|nose development|palate development|regulation of growth hormone secretion|regulation of transcription, DNA-dependent|retina development in camera-type eye|skeletal system development|T cell differentiation|transcription, DNA-dependent	nucleus	ATP binding|chromatin binding|DNA binding|helicase activity			ovary(4)|large_intestine(1)|central_nervous_system(1)|lung(1)|breast(1)|pancreas(1)	9		all_cancers(86;0.2)|all_lung(136;0.0402)|Lung NSC(129;0.0459)|all_epithelial(80;0.0477)	BRCA - Breast invasive adenocarcinoma(89;0.143)			TGTTGGAAGAAGATGGCAGAT	0.478		NaN											0	0	0	0.004672	0	3	12									
CHD7	55636	broad.mit.edu	37	8	61765060	61765060	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08			G	C	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr8:61765060G>C	uc003xue.2	+	30	6375	c.5898G>C	c.(5896-5898)TGG>TGC	p.W1966C		NM_017780	NP_060250	Q9P2D1	CHD7_HUMAN	chromodomain helicase DNA binding protein 7	1966					central nervous system development|chromatin modification|cognition|cranial nerve development|face development|heart morphogenesis|in utero embryonic development|inner ear morphogenesis|nose development|palate development|regulation of growth hormone secretion|regulation of transcription, DNA-dependent|retina development in camera-type eye|skeletal system development|T cell differentiation|transcription, DNA-dependent	nucleus	ATP binding|chromatin binding|DNA binding|helicase activity			ovary(4)|large_intestine(1)|central_nervous_system(1)|lung(1)|breast(1)|pancreas(1)	9		all_cancers(86;0.2)|all_lung(136;0.0402)|Lung NSC(129;0.0459)|all_epithelial(80;0.0477)	BRCA - Breast invasive adenocarcinoma(89;0.143)			CTAACAGGTGGACAAGAAGAG	0.383		NaN											0	0	0	0.008291	0	11	33									
TRHR	7201	broad.mit.edu	37	8	110100398	110100398	+	Silent	SNP	C	C	T			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr8:110100398C>T	uc003ymz.3	+	1	673	c.657C>T	c.(655-657)TTC>TTT	p.F219F		NM_003301	NP_003292	P34981	TRFR_HUMAN	thyrotropin-releasing hormone receptor	219	Cytoplasmic (Potential).					integral to plasma membrane	thyrotropin-releasing hormone receptor activity			skin(2)|lung(1)	3			OV - Ovarian serous cystadenocarcinoma(57;2.3e-11)			GAATCCTTTTCTTAAATCCCA	0.358		NaN											0	0	0	0.019004	0	34	119									
RAD21	5885	broad.mit.edu	37	8	117859890	117859890	+	Missense_Mutation	SNP	A	A	G			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr8:117859890A>G	uc003yod.2	-	14	2033	c.1745T>C	c.(1744-1746)CTT>CCT	p.L582P		NM_006265	NP_006256	O60216	RAD21_HUMAN	RAD21 homolog	582					apoptosis|cell division|chromosome segregation|double-strand break repair|mitotic metaphase/anaphase transition|mitotic prometaphase|protein localization to chromatin|reciprocal meiotic recombination|regulation of transcription from RNA polymerase II promoter	chromosome, centromeric region|cohesin complex|nuclear chromosome|nucleoplasm	protein binding			lung(1)|skin(1)	2	all_cancers(13;1.21e-21)|Lung NSC(37;0.000134)|Ovarian(258;0.0172)					ACATAACTCAAGCAAACTGAT	0.378		NaN											0	0	0	0.014323	0	23	101									
RAD21	5885	broad.mit.edu	37	8	117870623	117870623	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr8:117870623C>A	uc003yod.2	-	5	737	c.449G>T	c.(448-450)GGG>GTG	p.G150V		NM_006265	NP_006256	O60216	RAD21_HUMAN	RAD21 homolog	150					apoptosis|cell division|chromosome segregation|double-strand break repair|mitotic metaphase/anaphase transition|mitotic prometaphase|protein localization to chromatin|reciprocal meiotic recombination|regulation of transcription from RNA polymerase II promoter	chromosome, centromeric region|cohesin complex|nuclear chromosome|nucleoplasm	protein binding			lung(1)|skin(1)	2	all_cancers(13;1.21e-21)|Lung NSC(37;0.000134)|Ovarian(258;0.0172)					ACTGATGTTCCCAACTTCTTC	0.318		NaN											1	0	3.01185e-09	0.021523	3.147e-09	24	162									
EXT1	2131	broad.mit.edu	37	8	119122781	119122781	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr8:119122781G>A	uc003yok.1	-	1	1278	c.505C>T	c.(505-507)CAG>TAG	p.Q169*		NM_000127	NP_000118	Q16394	EXT1_HUMAN	exostosin 1	169	Lumenal (Potential).				glycosaminoglycan biosynthetic process|heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process|ossification|signal transduction|skeletal system development	Golgi membrane|integral to endoplasmic reticulum membrane	glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity|heparan sulfate N-acetylglucosaminyltransferase activity|N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity|protein heterodimerization activity|protein homodimerization activity			ovary(2)|lung(2)	4	all_cancers(13;2.36e-26)|Lung NSC(37;5.02e-07)|Ovarian(258;0.0173)		STAD - Stomach adenocarcinoma(47;0.012)			TGCACATACTGAGGTGACAAC	0.483		NaN	Mis|N|F|S			exostoses|osteosarcoma			Hereditary_Multiple_Exostoses|Langer-Giedion_syndrome				0	0	0	0.01441	0	228	202									
ZHX1	11244	broad.mit.edu	37	8	124267128	124267128	+	Silent	SNP	C	C	T			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr8:124267128C>T	uc003yqe.2	-	3	1489	c.1059G>A	c.(1057-1059)AGG>AGA	p.R353R	C8orf76_uc003yqd.2_Intron|ZHX1_uc003yqf.2_Silent_p.R353R|ZHX1_uc003yqg.2_Intron|ZHX1_uc010mdi.2_Silent_p.R353R	NM_007222	NP_009153	Q9UKY1	ZHX1_HUMAN	zinc fingers and homeoboxes 1	353	Required for dimerization.|Required for interaction with NFYA.				negative regulation of transcription, DNA-dependent	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1	Lung NSC(37;1.25e-09)|Ovarian(258;0.0154)		STAD - Stomach adenocarcinoma(47;0.00527)			TGAATTGTTTCCTTCTTGCCT	0.398		NaN											0	0	0	0.01441	0	284	240									
ATAD2	29028	broad.mit.edu	37	8	124371525	124371525	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr8:124371525C>G	uc003yqh.3	-	11	1426	c.1318G>C	c.(1318-1320)GAG>CAG	p.E440Q	ATAD2_uc011lii.1_Missense_Mutation_p.E231Q|ATAD2_uc003yqi.3_RNA|ATAD2_uc003yqj.2_Missense_Mutation_p.E440Q	NM_014109	NP_054828	Q6PL18	ATAD2_HUMAN	ATPase family, AAA domain containing 2	440					regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrion|nucleus	ATP binding|ATPase activity			ovary(2)	2	Lung NSC(37;1.25e-09)|Ovarian(258;0.00838)		STAD - Stomach adenocarcinoma(47;0.00288)			ACCACCATCTCTTTTAGAGCT	0.328		NaN											0	0	0	0.01441	0	81	333									
KLHL38	340359	broad.mit.edu	37	8	124664012	124664012	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr8:124664012G>C	uc003yqs.1	-	1	1179	c.1155C>G	c.(1153-1155)ATC>ATG	p.I385M		NM_001081675	NP_001075144	Q2WGJ6	KLH38_HUMAN	kelch-like 38	385	Kelch 3.										0						CGATGGAGAAGATGAAGTTCT	0.557		NaN											0	0	0	0.009535	0	30	130									
KIAA0196	9897	broad.mit.edu	37	8	126061284	126061284	+	Silent	SNP	G	G	A			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr8:126061284G>A	uc003yrt.2	-	19	2672	c.2343C>T	c.(2341-2343)AAC>AAT	p.N781N	KIAA0196_uc011lir.1_Silent_p.N633N|KIAA0196_uc003yru.1_Silent_p.N355N	NM_014846	NP_055661	Q12768	STRUM_HUMAN	strumpellin	781					cell death	WASH complex				ovary(2)	2	Ovarian(258;0.0028)|all_neural(195;0.00294)|Hepatocellular(40;0.108)		STAD - Stomach adenocarcinoma(47;0.000918)|COAD - Colon adenocarcinoma(160;0.205)			CTTGCTCCACGTTGTAATTTA	0.323		NaN											0	0	0	0.007413	0	19	94									
KHDRBS3	10656	broad.mit.edu	37	8	136594189	136594189	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr8:136594189G>T	uc003yuv.2	+	6	1074	c.680G>T	c.(679-681)GGA>GTA	p.G227V	KHDRBS3_uc003yuw.2_Missense_Mutation_p.G227V|KHDRBS3_uc010mek.2_RNA	NM_006558	NP_006549	O75525	KHDR3_HUMAN	KH domain containing, RNA binding, signal	227	Interaction with SIAH1.			Missing: Complete loss of SIAH1-mediated degradation.	regulation of transcription, DNA-dependent|spermatogenesis|transcription, DNA-dependent	nucleus	SH3 domain binding			ovary(2)	2	all_epithelial(106;2.85e-16)|all_neural(2;2.72e-06)|Lung NSC(106;3.95e-06)|all_lung(105;1.11e-05)|Ovarian(258;0.00579)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.247)			ACTCCCAGAGGAGTCCTGTCC	0.592		NaN											1	0	4.22769e-11	0.00632	4.47477e-11	29	101									
KHDRBS3	10656	broad.mit.edu	37	8	136594225	136594225	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr8:136594225G>T	uc003yuv.2	+	6	1110	c.716G>T	c.(715-717)AGA>ATA	p.R239I	KHDRBS3_uc003yuw.2_Missense_Mutation_p.R239I|KHDRBS3_uc010mek.2_RNA	NM_006558	NP_006549	O75525	KHDR3_HUMAN	KH domain containing, RNA binding, signal	239	Interaction with SIAH1.			Missing: Complete loss of SIAH1-mediated degradation.	regulation of transcription, DNA-dependent|spermatogenesis|transcription, DNA-dependent	nucleus	SH3 domain binding			ovary(2)	2	all_epithelial(106;2.85e-16)|all_neural(2;2.72e-06)|Lung NSC(106;3.95e-06)|all_lung(105;1.11e-05)|Ovarian(258;0.00579)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.247)			AGTCGGGGAAGAGGACTTCTC	0.587		NaN											1	0	4.7796e-09	0.004656	4.97812e-09	27	97									
SCRIB	23513	broad.mit.edu	37	8	144895029	144895029	+	Silent	SNP	G	G	A			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr8:144895029G>A	uc003yzp.1	-	8	752	c.745C>T	c.(745-747)CTG>TTG	p.L249L	SCRIB_uc003yzo.1_Silent_p.L249L	NM_015356	NP_056171	Q14160	SCRIB_HUMAN	scribble isoform b	249	LRR 10.|Sufficient for targeting to adherens junction and to inhibit cell proliferation.				activation of Rac GTPase activity|apoptosis involved in morphogenesis|cell migration|cell proliferation|cell-cell adhesion|establishment of apical/basal cell polarity|interspecies interaction between organisms|mammary gland duct morphogenesis|negative regulation of mitotic cell cycle|positive chemotaxis|positive regulation of apoptosis|positive regulation of receptor recycling|protein localization to adherens junction	cell-cell adherens junction|Scrib-APC-beta-catenin complex	protein binding			urinary_tract(1)|ovary(1)|kidney(1)|central_nervous_system(1)|pancreas(1)	5	all_cancers(97;2.31e-11)|all_epithelial(106;1.58e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;1.23e-39)|all cancers(56;1.12e-34)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.18)			TGGGACAGCAGCAGGTCAGTG	0.701		NaN											0	0	0	0.009096	0	3	18									
ADCK5	203054	broad.mit.edu	37	8	145608287	145608287	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr8:145608287C>G	uc003zch.2	+	3	176	c.122C>G	c.(121-123)TCC>TGC	p.S41C	ADCK5_uc003zcg.2_RNA	NM_174922	NP_777582	Q3MIX3	ADCK5_HUMAN	aarF domain containing kinase 5	41						integral to membrane	protein serine/threonine kinase activity			stomach(1)	1	all_cancers(97;6.64e-12)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;8.96e-41)|Epithelial(56;4.08e-40)|all cancers(56;4.51e-35)|BRCA - Breast invasive adenocarcinoma(115;0.0323)|Colorectal(110;0.055)			CTCAGGTTCTCCAGCCCCACA	0.672		NaN											0	0	0	0.009096	0	2	2									
GLDC	2731	broad.mit.edu	37	9	6589258	6589258	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr9:6589258C>G	uc003zkc.2	-	12	1710	c.1517G>C	c.(1516-1518)AGA>ACA	p.R506T		NM_000170	NP_000161	P23378	GCSP_HUMAN	glycine dehydrogenase (decarboxylating)	506					glycine catabolic process	mitochondrion	electron carrier activity|glycine dehydrogenase (decarboxylating) activity|lyase activity|pyridoxal phosphate binding			ovary(2)	2		Acute lymphoblastic leukemia(23;0.161)		GBM - Glioblastoma multiforme(50;0.0421)|Lung(218;0.134)	Glycine(DB00145)|Pyridoxal Phosphate(DB00114)	TGGAATACCTCTGCACTCCTC	0.517		NaN											0	0	0	0.007835	0	40	40									
PTPRD	5789	broad.mit.edu	37	9	8518200	8518200	+	Missense_Mutation	SNP	A	A	T			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr9:8518200A>T	uc003zkk.2	-	20	1902	c.1191T>A	c.(1189-1191)AAT>AAA	p.N397K	PTPRD_uc003zkp.2_Missense_Mutation_p.N397K|PTPRD_uc003zkq.2_Missense_Mutation_p.N397K|PTPRD_uc003zkr.2_Missense_Mutation_p.N391K|PTPRD_uc003zks.2_Missense_Mutation_p.N387K|PTPRD_uc003zkl.2_Missense_Mutation_p.N397K|PTPRD_uc003zkm.2_Missense_Mutation_p.N384K|PTPRD_uc003zkn.2_Missense_Mutation_p.N397K|PTPRD_uc003zko.2_Missense_Mutation_p.N394K	NM_002839	NP_002830	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	397	Fibronectin type-III 1.|Extracellular (Potential).				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			lung(14)|large_intestine(3)|ovary(2)|breast(2)|urinary_tract(1)	22		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		GCCCAATGTTATTGACAGCAA	0.522		NaN								TSP Lung(15;0.13)			0	0	0	0.01441	0	57	186									
KLHL9	55958	broad.mit.edu	37	9	21334596	21334596	+	Missense_Mutation	SNP	T	T	C			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr9:21334596T>C	uc003zoy.2	-	1	834	c.263A>G	c.(262-264)CAA>CGA	p.Q88R	KLHL9_uc003zow.2_Intron|KLHL9_uc003zox.2_RNA	NM_018847	NP_061335	Q9P2J3	KLHL9_HUMAN	kelch-like 9	88	BTB.				cytokinesis|mitosis|protein ubiquitination	Cul3-RING ubiquitin ligase complex|midbody				ovary(3)|skin(1)	4				Lung(24;8.52e-27)|LUSC - Lung squamous cell carcinoma(38;1.4e-13)|OV - Ovarian serous cystadenocarcinoma(39;0.118)		CATCAAATCTTGTTCTTTCAT	0.378		NaN											0	0	0	0.01441	0	72	266									
IFT74	80173	broad.mit.edu	37	9	26984496	26984496	+	Splice_Site	SNP	G	G	A			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr9:26984496G>A	uc010mja.2	+	6	532	c.405_splice	c.e6-1	p.R135_splice	IFT74_uc010mjb.2_Splice_Site_p.R135_splice|IFT74_uc003zqf.3_Splice_Site_p.R135_splice|IFT74_uc003zqg.3_Splice_Site_p.R135_splice	NM_001099223	NP_001092693	Q96LB3	IFT74_HUMAN	coiled-coil domain containing 2 isoform a							cytoplasmic membrane-bounded vesicle|intraflagellar transport particle B|microtubule-based flagellum				skin(1)	1		all_neural(11;2.36e-10)		Lung(218;1.4e-05)|LUSC - Lung squamous cell carcinoma(38;0.000114)		TATGCTTTCAGGGCTGAGACT	0.269		NaN											0	0	0	0.01441	0	70	143									
KIAA1161	57462	broad.mit.edu	37	9	34372097	34372097	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr9:34372097C>T	uc003zue.3	-	3	1012	c.845G>A	c.(844-846)CGA>CAA	p.R282Q		NM_020702	NP_065753	Q6NSJ0	K1161_HUMAN	hypothetical protein LOC57462	282	Extracellular (Potential).				carbohydrate metabolic process	integral to membrane	hydrolase activity, hydrolyzing O-glycosyl compounds			ovary(1)|breast(1)|central_nervous_system(1)	3			LUSC - Lung squamous cell carcinoma(29;0.0107)	GBM - Glioblastoma multiforme(74;0.126)		CACGCACACTCGGTAGCTCAG	0.662		NaN											0	0	0	0.00308	0	7	35									
C9orf131	138724	broad.mit.edu	37	9	35044993	35044993	+	Silent	SNP	C	C	G			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr9:35044993C>G	uc003zvw.2	+	2	2396	c.2367C>G	c.(2365-2367)CTC>CTG	p.L789L	C9orf131_uc003zvu.2_Silent_p.L741L|C9orf131_uc003zvv.2_Silent_p.L716L|C9orf131_uc003zvx.2_Silent_p.L754L	NM_203299	NP_976044	Q5VYM1	CI131_HUMAN	hypothetical protein LOC138724 isoform A	789											0	all_epithelial(49;0.22)		LUSC - Lung squamous cell carcinoma(32;0.00117)|Lung(28;0.00309)			AGCTGAAACTCAGGCTGAAGA	0.567		NaN											0	0	0	0.01441	0	103	173									
TLN1	7094	broad.mit.edu	37	9	35697854	35697854	+	Silent	SNP	C	C	T			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr9:35697854C>T	uc003zxt.2	-	57	7914	c.7560G>A	c.(7558-7560)AAG>AAA	p.K2520K		NM_006289	NP_006280	Q9Y490	TLN1_HUMAN	talin 1	2520	I/LWEQ.				axon guidance|cell adhesion|cell-cell junction assembly|cellular component movement|cytoskeletal anchoring at plasma membrane|muscle contraction|platelet activation|platelet degranulation	actin cytoskeleton|centrosome|cytosol|extracellular region|focal adhesion|intracellular membrane-bounded organelle|ruffle membrane	actin binding|insulin receptor binding|LIM domain binding|structural constituent of cytoskeleton|vinculin binding			lung(7)|breast(3)|ovary(2)|central_nervous_system(1)	13	all_epithelial(49;0.167)		Lung(28;0.00276)|LUSC - Lung squamous cell carcinoma(32;0.00418)|STAD - Stomach adenocarcinoma(86;0.194)			GGGCCAGTTTCTTCCGCGCCT	0.532		NaN									OREG0019174	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.016723	0	14	64									
TJP2	9414	broad.mit.edu	37	9	71844146	71844146	+	Silent	SNP	T	T	G			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr9:71844146T>G	uc004ahe.2	+	10	1700	c.1500T>G	c.(1498-1500)CCT>CCG	p.P500P	TJP2_uc011lrs.1_Silent_p.P477P|TJP2_uc011lrt.1_Silent_p.P477P|TJP2_uc004ahd.2_Silent_p.P500P|TJP2_uc004ahf.2_Silent_p.P500P|TJP2_uc011lru.1_Silent_p.P504P|TJP2_uc011lrv.1_Silent_p.P522P	NM_004817	NP_004808	Q9UDY2	ZO2_HUMAN	tight junction protein 2 (zona occludens 2)	500					cellular component disassembly involved in apoptosis	adherens junction|cytoplasm|nucleus|tight junction	guanylate kinase activity|protein binding				0						GTCCTAGTCCTGAAGATGAAG	0.423		NaN											0	0	0	0.01441	0	66	55									
TRPM6	140803	broad.mit.edu	37	9	77377272	77377272	+	Missense_Mutation	SNP	G	G	A	rs144291419		TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr9:77377272G>A	uc004ajl.1	-	26	4553	c.4315C>T	c.(4315-4317)CCT>TCT	p.P1439S	TRPM6_uc004ajk.1_Missense_Mutation_p.P1434S|TRPM6_uc010mpb.1_RNA|TRPM6_uc010mpc.1_Intron|TRPM6_uc010mpd.1_Intron|TRPM6_uc010mpe.1_Intron|TRPM6_uc004ajj.1_Missense_Mutation_p.P395S	NM_017662	NP_060132	Q9BX84	TRPM6_HUMAN	transient receptor potential cation channel,	1439	Cytoplasmic (Potential).				response to toxin	integral to membrane	ATP binding|calcium channel activity|metal ion binding|protein binding|protein serine/threonine kinase activity			lung(3)|stomach(2)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|skin(1)	8						TGGGAAAGAGGGGAGCTCATT	0.463		NaN											0	0	0	0.004656	0	25	69									
PCSK5	5125	broad.mit.edu	37	9	78784732	78784732	+	Nonsense_Mutation	SNP	C	C	T			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr9:78784732C>T	uc004ajz.2	+	13	2270	c.1732C>T	c.(1732-1734)CAG>TAG	p.Q578*	PCSK5_uc004ajy.2_Nonsense_Mutation_p.Q578*|PCSK5_uc004aka.2_RNA	NM_006200	NP_006191	Q92824	PCSK5_HUMAN	proprotein convertase subtilisin/kexin type 5	578	Homo B/P.				anterior/posterior pattern formation|cell-cell signaling|cytokine biosynthetic process|embryo implantation|embryonic digestive tract development|embryonic skeletal system development|heart development|kidney development|limb morphogenesis|nerve growth factor processing|nerve growth factor receptor signaling pathway|peptide biosynthetic process|renin secretion into blood stream|respiratory tube development|signal peptide processing|viral assembly, maturation, egress, and release	extracellular space|Golgi lumen|stored secretory granule	peptide binding|serine-type endopeptidase activity			ovary(2)|skin(1)	3						TACTCCCTCTCAGCTAAGGAA	0.428		NaN											0	0	0	0.01441	0	51	89									
BICD2	23299	broad.mit.edu	37	9	95477535	95477535	+	Silent	SNP	G	G	A			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr9:95477535G>A	uc004aso.1	-	7	2526	c.2469C>T	c.(2467-2469)AGC>AGT	p.S823S	BICD2_uc004asp.1_Silent_p.S823S	NM_015250	NP_056065	Q8TD16	BICD2_HUMAN	bicaudal D homolog 2 isoform 2	823					microtubule anchoring at microtubule organizing center|minus-end-directed organelle transport along microtubule	cytoplasmic vesicle|cytoskeleton|Golgi apparatus|plasma membrane	Rab GTPase binding			skin(1)	1						TGTGACTTACGCTCGGTGTGG	0.652		NaN											0	0	0	0.00308	0	5	4									
PTCH1	5727	broad.mit.edu	37	9	98221997	98221997	+	Silent	SNP	C	C	A			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr9:98221997C>A	uc004avk.3	-	17	2960	c.2772G>T	c.(2770-2772)ACG>ACT	p.T924T	PTCH1_uc010mro.2_Silent_p.T773T|PTCH1_uc010mrp.2_Silent_p.T773T|PTCH1_uc010mrq.2_Silent_p.T773T|PTCH1_uc004avl.3_Silent_p.T773T|PTCH1_uc010mrr.2_Silent_p.T858T|PTCH1_uc004avm.3_Silent_p.T923T	NM_000264	NP_000255	Q13635	PTC1_HUMAN	patched isoform L	924	Extracellular (Potential).				embryonic limb morphogenesis|negative regulation of multicellular organism growth|protein processing|regulation of smoothened signaling pathway|smoothened signaling pathway	integral to plasma membrane	hedgehog receptor activity			skin(242)|central_nervous_system(72)|bone(33)|upper_aerodigestive_tract(11)|lung(6)|large_intestine(4)|breast(4)|oesophagus(3)|ovary(3)|vulva(1)	379		Medulloblastoma(1;7.87e-06)|all_neural(1;0.000555)|Acute lymphoblastic leukemia(62;0.136)				TGACCCAAGCCGTCAGGTAGA	0.552		NaN							Basal_Cell_Nevus_syndrome				1	0	3.5997e-14	0.014323	3.83497e-14	24	29									
ZNF322B	387328	broad.mit.edu	37	9	99960733	99960733	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr9:99960733G>A	uc004axd.1	-	1	1178	c.1061C>T	c.(1060-1062)ACT>ATT	p.T354I	uc004axb.2_5'Flank|ZNF322B_uc004axc.1_5'Flank|uc010msl.1_Intron	NM_199005	NP_945356			zinc finger protein 322B												0		Acute lymphoblastic leukemia(62;0.158)				ATCACATACAGTGTATTTATA	0.433		NaN											0	0	0	0.01441	0	61	128									
SMC2	10592	broad.mit.edu	37	9	106894304	106894304	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr9:106894304G>C	uc004bbv.2	+	22	3294	c.3006G>C	c.(3004-3006)ATG>ATC	p.M1002I	SMC2_uc004bbw.2_Missense_Mutation_p.M1002I|SMC2_uc011lvl.1_Missense_Mutation_p.M1002I|SMC2_uc004bbx.2_Missense_Mutation_p.M1002I|SMC2_uc004bby.2_RNA	NM_001042551	NP_001036016	O95347	SMC2_HUMAN	structural maintenance of chromosomes 2	1002	Potential.				cell division|mitotic chromosome condensation|symbiosis, encompassing mutualism through parasitism	condensin complex|cytoplasm|nuclear chromosome	ATP binding|protein heterodimerization activity			ovary(4)|skin(2)|haematopoietic_and_lymphoid_tissue(1)|lung(1)|breast(1)	9						ATGACTTGATGAAGAAGAAGA	0.303		NaN											0	0	0	0.021523	0	26	24									
CRAT	1384	broad.mit.edu	37	9	131864786	131864786	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr9:131864786G>C	uc004bxh.2	-	5	805	c.523C>G	c.(523-525)CAG>GAG	p.Q175E	CRAT_uc004bxg.2_Missense_Mutation_p.Q154E|CRAT_uc004bxk.3_Missense_Mutation_p.Q154E	NM_000755	NP_000746	P43155	CACP_HUMAN	carnitine acetyltransferase precursor	175					energy derivation by oxidation of organic compounds|fatty acid beta-oxidation using acyl-CoA oxidase|transport	endoplasmic reticulum|mitochondrial inner membrane|peroxisomal matrix	carnitine O-acetyltransferase activity			central_nervous_system(1)	1				UCEC - Uterine corpus endometrioid carcinoma (4;0.0178)	L-Carnitine(DB00583)	GACAAGATCTGATAGTACTGG	0.597		NaN											0	0	0	0.01441	0	89	170									
DMD	1756	broad.mit.edu	37	X	32662325	32662325	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chrX:32662325C>T	uc004dda.1	-	11	1499	c.1255G>A	c.(1255-1257)GAA>AAA	p.E419K	DMD_uc004dcz.2_Missense_Mutation_p.E296K|DMD_uc004dcy.1_Missense_Mutation_p.E415K|DMD_uc004ddb.1_Missense_Mutation_p.E411K|DMD_uc010ngo.1_Intron|DMD_uc004ddf.2_Missense_Mutation_p.E411K|DMD_uc010ngp.1_Intron|DMD_uc010ngq.1_Intron|MIR548F5_hsa-mir-548f-5|MI0006378_5'Flank	NM_004006	NP_003997	P11532	DMD_HUMAN	dystrophin Dp427m isoform	419	Spectrin 1.				muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			ovary(3)|pancreas(2)|large_intestine(1)	6		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				TCTTGTACTTCAGTTTCTTCA	0.388		NaN											0	0	0	0.01441	0	134	24									
FAM47A	158724	broad.mit.edu	37	X	34150089	34150089	+	Silent	SNP	G	G	A			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chrX:34150089G>A	uc004ddg.2	-	1	340	c.307C>T	c.(307-309)CTA>TTA	p.L103L		NM_203408	NP_981953	Q5JRC9	FA47A_HUMAN	hypothetical protein LOC158724	103										ovary(4)|central_nervous_system(1)	5						TTGGAAAATAGGGCCGCTTTC	0.542		NaN											0	0	0	0.01441	0	94	14									
CXorf22	170063	broad.mit.edu	37	X	35959432	35959432	+	Nonsense_Mutation	SNP	C	C	G			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chrX:35959432C>G	uc004ddj.2	+	3	493	c.434C>G	c.(433-435)TCA>TGA	p.S145*	CXorf22_uc010ngv.2_RNA	NM_152632	NP_689845	Q6ZTR5	CX022_HUMAN	hypothetical protein LOC170063	145										large_intestine(1)|lung(1)|ovary(1)	3						GAAATTGAATCAGTAGTTAAT	0.358		NaN											0	0	0	0.009535	0	29	52									
PLP2	5355	broad.mit.edu	37	X	49029745	49029745	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chrX:49029745G>A	uc004dmx.2	+	3	335	c.260G>A	c.(259-261)CGA>CAA	p.R87Q		NM_002668	NP_002659	Q04941	PLP2_HUMAN	proteolipid protein 2 (colonic	87	Helical; (Potential).|MARVEL.				chemotaxis|cytokine-mediated signaling pathway	endoplasmic reticulum membrane|integral to membrane|membrane fraction|plasma membrane	chemokine binding|ion transmembrane transporter activity				0						GATTTCTTCCGAACCCTCATA	0.532		NaN											0	0	0	0.015359	0	31	47									
CCNB3	85417	broad.mit.edu	37	X	50031856	50031856	+	Missense_Mutation	SNP	A	A	G			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chrX:50031856A>G	uc004dox.3	+	4	471	c.173A>G	c.(172-174)AAA>AGA	p.K58R	CCNB3_uc004doy.2_Missense_Mutation_p.K58R|CCNB3_uc004doz.2_Missense_Mutation_p.K58R|CCNB3_uc010njq.2_5'UTR	NM_033031	NP_149020	Q8WWL7	CCNB3_HUMAN	cyclin B3 isoform 3	58					cell division|meiosis|regulation of cyclin-dependent protein kinase activity|regulation of G2/M transition of mitotic cell cycle	nucleus	protein kinase binding			ovary(4)|lung(3)|large_intestine(1)|pancreas(1)	9	Ovarian(276;0.236)					GGAGCACTCAAAAAGAGATCA	0.413		NaN											0	0	0	0.006122	0	19	3									
KIAA2022	340533	broad.mit.edu	37	X	73962682	73962682	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chrX:73962682C>G	uc004eby.2	-	3	2327	c.1710G>C	c.(1708-1710)TTG>TTC	p.L570F		NM_001008537	NP_001008537	Q5QGS0	K2022_HUMAN	hypothetical protein LOC340533	570					base-excision repair, gap-filling|DNA replication proofreading|DNA replication, removal of RNA primer|nucleotide-excision repair, DNA gap filling|regulation of mitotic cell cycle|S phase of mitotic cell cycle	delta DNA polymerase complex	3'-5'-exodeoxyribonuclease activity|DNA-directed DNA polymerase activity			ovary(7)|large_intestine(4)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	15						GATTCTCACTCAAATTCACTG	0.418		NaN											0	0	0	0.007835	0	39	56									
STAG2	10735	broad.mit.edu	37	X	123190029	123190029	+	Silent	SNP	G	G	T	rs142571900		TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chrX:123190029G>T	uc004etz.3	+	13	1587	c.1248G>T	c.(1246-1248)CTG>CTT	p.L416L	STAG2_uc004eua.2_Silent_p.L416L|STAG2_uc004eub.2_Silent_p.L416L|STAG2_uc004euc.2_Silent_p.L416L|STAG2_uc004eud.2_Silent_p.L416L|STAG2_uc004eue.2_Silent_p.L416L	NM_006603	NP_006594	Q8N3U4	STAG2_HUMAN	stromal antigen 2 isoform b	416					cell division|meiosis|mitotic metaphase/anaphase transition|mitotic prometaphase|negative regulation of DNA endoreduplication|sister chromatid cohesion	chromatin|chromosome, centromeric region|nucleoplasm	protein binding			ovary(4)|skin(1)	5						TCTATCATCTGGTTTATTCAG	0.368		NaN											1	0	3.43241e-23	0.009718	3.78029e-23	37	53									
DCAF12L1	139170	broad.mit.edu	37	X	125686323	125686323	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chrX:125686323C>T	uc004eul.2	-	1	520	c.269G>A	c.(268-270)CGC>CAC	p.R90H		NM_178470	NP_848565	Q5VU92	DC121_HUMAN	DDB1 and CUL4 associated factor 12-like 1	90										skin(3)|ovary(1)	4						CTCCAGTTGGCGCTCCGTCAG	0.662		NaN											0	0	0	0.00499	0	16	24									
MCF2	4168	broad.mit.edu	37	X	138672035	138672035	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chrX:138672035C>G	uc004fau.2	-	20	2623	c.2329G>C	c.(2329-2331)GAA>CAA	p.E777Q	MCF2_uc004fav.2_Missense_Mutation_p.E793Q|MCF2_uc011mwl.1_Missense_Mutation_p.E754Q|MCF2_uc010nsh.1_Missense_Mutation_p.E777Q|MCF2_uc011mwm.1_Missense_Mutation_p.E738Q|MCF2_uc011mwn.1_Missense_Mutation_p.E922Q|MCF2_uc004faw.2_Missense_Mutation_p.E837Q|MCF2_uc011mwo.1_Missense_Mutation_p.E853Q	NM_005369	NP_005360	P10911	MCF2_HUMAN	MCF.2 cell line derived transforming sequence	777	PH.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytoskeleton|cytosol|membrane|membrane fraction	protein binding|Rho guanyl-nucleotide exchange factor activity			lung(1)|pleura(1)	2	Acute lymphoblastic leukemia(192;0.000127)					TACCAGATTTCAAACTTGCGG	0.318		NaN											0	0	0	0.021523	0	26	50									
TCHHL1	126637	broad.mit.edu	37	1	152059043	152059044	+	Frame_Shift_Ins	INS	-	-	G			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr1:152059043_152059044insG	uc001ezo.1	-	3	1179_1180	c.1114_1115insC	c.(1114-1116)CTGfs	p.L372fs		NM_001008536	NP_001008536	Q5QJ38	TCHL1_HUMAN	trichohyalin-like 1	372							calcium ion binding			ovary(1)|skin(1)	2	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.246)			TTGGACTGGCAGGTCCTTTGTT	0.465		NaN											NaN	NaN	NaN	NaN	NaN	7	949	---	---							
HAX1	10456	broad.mit.edu	37	1	154245864	154245866	+	In_Frame_Del	DEL	GAA	GAA	-	rs11556342		TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr1:154245864_154245866delGAA	uc001fes.2	+	2	267_269	c.106_108delGAA	c.(106-108)GAAdel	p.E40del	HAX1_uc001fet.2_Intron|HAX1_uc010peo.1_In_Frame_Del_p.E40del|HAX1_uc009wou.2_5'UTR|HAX1_uc009wov.2_In_Frame_Del_p.E14del	NM_006118	NP_006109	O00165	HAX1_HUMAN	HCLS1 associated protein X-1 isoform a	40	Asp/Glu-rich (highly acidic).|Required for localization in mitochondria (By similarity).					actin cytoskeleton|cytoplasmic membrane-bounded vesicle|lamellipodium|mitochondrion|nuclear membrane|sarcoplasmic reticulum|soluble fraction	interleukin-1 binding|protein N-terminus binding				0	all_lung(78;2.62e-30)|Lung NSC(65;3.94e-28)|Hepatocellular(266;0.0877)		LUSC - Lung squamous cell carcinoma(543;0.185)			TGATGATGAGGAAGAAGAAGAAG	0.522		NaN							Kostmann_syndrome				NaN	NaN	NaN	NaN	NaN	9	176	---	---							
NXF1	10482	broad.mit.edu	37	11	62560155	62560157	+	In_Frame_Del	DEL	GTT	GTT	-			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr11:62560155_62560157delGTT	uc001nvf.1	-	20	1913_1915	c.1777_1779delAAC	c.(1777-1779)AACdel	p.N593del	TMEM223_uc001nve.2_5'Flank|NXF1_uc001nvg.1_3'UTR	NM_006362	NP_006353	Q9UBU9	NXF1_HUMAN	nuclear RNA export factor 1 isoform 1	593	TAP-C.				gene expression|interspecies interaction between organisms	cytosol|nuclear speck	nucleotide binding|protein binding			skin(3)	3						TGTAGTCCCAGTTGTTGTCCTGA	0.384		NaN											NaN	NaN	NaN	NaN	NaN	22	67	---	---							
NCAM1	4684	broad.mit.edu	37	11	113102975	113102975	+	Frame_Shift_Del	DEL	C	C	-			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr11:113102975delC	uc009yyq.1	+	12	1742	c.1048delC	c.(1048-1050)CCCfs	p.P350fs		NM_001076682	NP_001070150	P13591	NCAM1_HUMAN	neural cell adhesion molecule 1 isoform 3	442	Ig-like C2-type 5.|Extracellular (Potential).				axon guidance|interferon-gamma-mediated signaling pathway	anchored to membrane|extracellular region|Golgi membrane|integral to membrane				ovary(1)	1		all_cancers(61;5.82e-19)|all_epithelial(67;6.87e-12)|Melanoma(852;1.99e-05)|all_hematologic(158;3.66e-05)|Acute lymphoblastic leukemia(157;0.00119)|Breast(348;0.0109)|all_neural(223;0.0299)|Medulloblastoma(222;0.0458)|Renal(330;0.198)|Prostate(24;0.207)		BRCA - Breast invasive adenocarcinoma(274;1.78e-05)|Epithelial(105;0.000114)|all cancers(92;0.000467)|OV - Ovarian serous cystadenocarcinoma(223;0.212)		ATTTGCCTATCCCAGTGCCAC	0.517		NaN											NaN	NaN	NaN	NaN	NaN	17	36	---	---							
MLL2	8085	broad.mit.edu	37	12	49427929	49427933	+	Frame_Shift_Del	DEL	CGGCC	CGGCC	-			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08			CGGCC	-	CGGCC	CGGCC		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr12:49427929_49427933delCGGCC	uc001rta.3	-	38	10657_10661	c.10657_10661delGGCCG	c.(10657-10662)GGCCGTfs	p.G3553fs		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	3553_3554	Gln-rich.				chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						TGGGAACTCACGGCCAGCTTTTTTG	0.541		NaN	N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			NaN	NaN	NaN	NaN	NaN	38	60	---	---							
FANCM	57697	broad.mit.edu	37	14	45623913	45623913	+	Frame_Shift_Del	DEL	A	A	-			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr14:45623913delA	uc001wwd.3	+	7	1296	c.1197delA	c.(1195-1197)TCAfs	p.S399fs	FANCM_uc001wwc.2_Frame_Shift_Del_p.S399fs|FANCM_uc010anf.2_Frame_Shift_Del_p.S373fs|FANCM_uc001wwe.3_Frame_Shift_Del_p.S4fs	NM_020937	NP_065988	Q8IYD8	FANCM_HUMAN	Fanconi anemia, complementation group M	399					DNA repair	Fanconi anaemia nuclear complex	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding|nuclease activity|protein binding			ovary(3)|lung(2)|breast(2)	7						TGACACGGTCAAAAAATGAAC	0.269		NaN						Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				NaN	NaN	NaN	NaN	NaN	34	39	---	---							
UFSP2	55325	broad.mit.edu	37	4	186329155	186329156	+	Frame_Shift_Ins	INS	-	-	TG			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr4:186329155_186329156insTG	uc003ixo.2	-	9	1172_1173	c.1055_1056insCA	c.(1054-1056)GGAfs	p.G352fs	UFSP2_uc003ixn.2_Frame_Shift_Ins_p.G227fs|UFSP2_uc003ixq.2_Frame_Shift_Ins_p.G242fs|UFSP2_uc003ixp.2_RNA	NM_018359	NP_060829	Q9NUQ7	UFSP2_HUMAN	UFM1-specific peptidase 2	352						endoplasmic reticulum|nucleus	small conjugating protein-specific protease activity				0		all_lung(41;1.3e-11)|Lung NSC(41;2.25e-11)|Melanoma(20;0.00109)|Colorectal(36;0.0215)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|all_hematologic(60;0.0749)		all cancers(43;3.4e-25)|Epithelial(43;2.23e-22)|OV - Ovarian serous cystadenocarcinoma(60;1.54e-11)|BRCA - Breast invasive adenocarcinoma(30;8.1e-05)|GBM - Glioblastoma multiforme(59;0.000148)|STAD - Stomach adenocarcinoma(60;0.000782)|LUSC - Lung squamous cell carcinoma(40;0.00939)|COAD - Colon adenocarcinoma(29;0.0108)|READ - Rectum adenocarcinoma(43;0.166)		CCTCAATAGATCCAATCCATTG	0.391		NaN											NaN	NaN	NaN	NaN	NaN	23	45	---	---							
UBLCP1	134510	broad.mit.edu	37	5	158702181	158702183	+	In_Frame_Del	DEL	ATT	ATT	-			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr5:158702181_158702183delATT	uc003lxq.2	+	8	937_939	c.611_613delATT	c.(610-615)AATTAT>AAT	p.Y205del		NM_145049	NP_659486	Q8WVY7	UBCP1_HUMAN	ubiquitin-like domain containing CTD phosphatase	205	FCP1 homology.					nucleus	phosphoprotein phosphatase activity			ovary(1)	1	Renal(175;0.00196)	Medulloblastoma(196;0.0523)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			ACAAATGCAAATTATAAGATTAC	0.325		NaN											NaN	NaN	NaN	NaN	NaN	24	61	---	---							
POM121	9883	broad.mit.edu	37	7	72410394	72410395	+	Frame_Shift_Del	DEL	AC	AC	-			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr7:72410394_72410395delAC	uc003twk.2	+	8	1450_1451	c.1450_1451delAC	c.(1450-1452)ACAfs	p.T484fs	POM121_uc003twj.2_Frame_Shift_Del_p.T219fs|POM121_uc010lam.1_Frame_Shift_Del_p.T219fs	NM_172020	NP_742017	Q96HA1	P121A_HUMAN	nuclear pore membrane protein 121	484	Pore side (Potential).				carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	endoplasmic reticulum membrane|nuclear membrane|nuclear pore					0		Lung NSC(55;0.163)				AGCTGCAGATACAACCCCAAGG	0.48		NaN											NaN	NaN	NaN	NaN	NaN	115	181	---	---							
MYST3	7994	broad.mit.edu	37	8	41798420	41798422	+	In_Frame_Del	DEL	CTC	CTC	-			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr8:41798420_41798422delCTC	uc010lxb.2	-	16	3521_3523	c.2977_2979delGAG	c.(2977-2979)GAGdel	p.E993del	MYST3_uc010lxc.2_In_Frame_Del_p.E993del|MYST3_uc003xon.3_In_Frame_Del_p.E993del	NM_001099412	NP_001092882	Q92794	MYST3_HUMAN	MYST histone acetyltransferase (monocytic	993	Poly-Glu.				histone H3 acetylation|myeloid cell differentiation|negative regulation of transcription, DNA-dependent|nucleosome assembly|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	MOZ/MORF histone acetyltransferase complex|nucleosome	DNA binding|histone acetyltransferase activity|transcription coactivator activity|transcription factor binding|zinc ion binding			ovary(4)|pancreas(1)|central_nervous_system(1)|skin(1)	7	all_epithelial(6;1.12e-27)|all_lung(13;3.94e-12)|Lung NSC(13;6.54e-11)|Ovarian(28;0.00744)|Prostate(17;0.0119)|Colorectal(14;0.0221)|Lung SC(25;0.211)	all_lung(54;0.000294)|Lung NSC(58;0.00105)|Hepatocellular(245;0.0524)|Esophageal squamous(32;0.0954)|Renal(179;0.0983)	Epithelial(1;2.82e-19)|all cancers(1;1.15e-16)|BRCA - Breast invasive adenocarcinoma(8;9.17e-11)|OV - Ovarian serous cystadenocarcinoma(14;9.4e-05)|Colorectal(10;0.000728)|Lung(22;0.00153)|LUSC - Lung squamous cell carcinoma(45;0.00741)|COAD - Colon adenocarcinoma(11;0.0171)			GGCTTTCCGGCTCCTCCTCCTCC	0.567		NaN											NaN	NaN	NaN	NaN	NaN	10	434	---	---							
EIF2C2	27161	broad.mit.edu	37	8	141549532	141549532	+	Frame_Shift_Del	DEL	C	C	-			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr8:141549532delC	uc003yvn.2	-	16	2096	c.2056delG	c.(2056-2058)GCCfs	p.A686fs	EIF2C2_uc010men.2_Frame_Shift_Del_p.A609fs|EIF2C2_uc010meo.2_Frame_Shift_Del_p.A686fs	NM_012154	NP_036286	Q9UKV8	AGO2_HUMAN	argonaute 2 isoform 1	686	Piwi.				mRNA cleavage involved in gene silencing by miRNA|negative regulation of translation involved in gene silencing by miRNA|negative regulation of translational initiation|pre-miRNA processing|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol|micro-ribonucleoprotein complex|mRNA cap binding complex|nucleus|polysome|RNA-induced silencing complex	endoribonuclease activity, cleaving siRNA-paired mRNA|metal ion binding|protein binding|RNA 7-methylguanosine cap binding|siRNA binding|translation initiation factor activity				0	all_cancers(97;2.54e-14)|all_epithelial(106;5.99e-13)|Lung NSC(106;1.45e-05)|all_lung(105;2.07e-05)|Ovarian(258;0.0154)|Acute lymphoblastic leukemia(118;0.155)	Breast(495;0.159)	BRCA - Breast invasive adenocarcinoma(115;0.158)			TCACGGATGGCCAGCAACTCG	0.572		NaN											NaN	NaN	NaN	NaN	NaN	25	112	---	---