Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	isArtifactMode	oxoGCut	pox	pox_cutoff	qox	t_alt_count	t_ref_count	validation_alt_allele	validation_tumor_sample							
PRAMEF2	65122	broad.mit.edu	37	1	12921316	12921316	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr1:12921316C>G	uc001aum.1	+	4	1194	c.1107C>G	c.(1105-1107)ATC>ATG	p.I369M		NM_023014	NP_075390	O60811	PRAM2_HUMAN	PRAME family member 2	369	LRR 2.										0	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.00224)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;2.4e-06)|Kidney(185;4.89e-05)|COAD - Colon adenocarcinoma(227;0.000152)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		TCAGTGCCATCCTGCCTGGCC	0.562		NaN											0	0	0	0.00308	0	7	187									
KIAA0754	643314	broad.mit.edu	37	1	39878410	39878410	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr1:39878410G>C	uc009vvt.1	+	1	3235	c.2473G>C	c.(2473-2475)GAG>CAG	p.E825Q	MACF1_uc010ois.1_Intron|MACF1_uc001cda.1_Intron|MACF1_uc001cdc.1_Intron|MACF1_uc010oiu.1_Intron	NM_015038	NP_055853	O94854	K0754_HUMAN	hypothetical protein LOC643314	689											0	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0393)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			ACCAGTTTTAGAGGAATGGAT	0.493		NaN											0	0	0	0.009096	0	3	24									
CTPS	1503	broad.mit.edu	37	1	41471729	41471729	+	Missense_Mutation	SNP	A	A	G			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr1:41471729A>G	uc001cgk.3	+	13	1767	c.1259A>G	c.(1258-1260)AAT>AGT	p.N420S	CTPS_uc010ojo.1_Missense_Mutation_p.N189S|CTPS_uc001cgl.3_Missense_Mutation_p.N420S|CTPS_uc010ojq.1_Missense_Mutation_p.N264S|CTPS_uc009vwe.2_Missense_Mutation_p.N140S	NM_001905	NP_001896	P17812	PYRG1_HUMAN	CTP synthase	420	Glutamine amidotransferase type-1.				CTP biosynthetic process|glutamine metabolic process|nucleobase, nucleoside and nucleotide interconversion|response to drug	cytosol	ATP binding|CTP synthase activity|protein binding				0	Ovarian(52;0.00579)|all_hematologic(146;0.0977)|Breast(333;0.1)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0255)			L-Glutamine(DB00130)	TCAGATGCCAATTCTACAGAG	0.408		NaN											0	0	0	0.004672	0	3	119									
C8B	732	broad.mit.edu	37	1	57409489	57409489	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr1:57409489G>C	uc001cyp.2	-	8	1181	c.1114C>G	c.(1114-1116)CTT>GTT	p.L372V	C8B_uc010oon.1_Missense_Mutation_p.L310V|C8B_uc010ooo.1_Missense_Mutation_p.L320V	NM_000066	NP_000057	P07358	CO8B_HUMAN	complement component 8, beta polypeptide	372	MACPF.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis	membrane attack complex				central_nervous_system(2)|large_intestine(1)|ovary(1)	4						ACGTTGTTAAGAGTATAATCT	0.443		NaN											0	0	0	0.021553	0	6	112									
LRRC7	57554	broad.mit.edu	37	1	70504020	70504020	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr1:70504020G>A	uc001dep.2	+	19	2429	c.2399G>A	c.(2398-2400)AGA>AAA	p.R800K	LRRC7_uc009wbg.2_Missense_Mutation_p.R84K|LRRC7_uc001deq.2_Missense_Mutation_p.R41K	NM_020794	NP_065845	Q96NW7	LRRC7_HUMAN	leucine rich repeat containing 7	800						centrosome|focal adhesion|nucleolus	protein binding			ovary(9)|breast(2)|central_nervous_system(2)|liver(1)	14						TCGAAATCTAGAAGCACATCT	0.488		NaN											0	0	0	0.010729	0	11	181									
PSMD4	5710	broad.mit.edu	37	1	151238867	151238867	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr1:151238867G>C	uc001exl.2	+	8	909	c.847G>C	c.(847-849)GAG>CAG	p.E283Q	PSMD4_uc001exn.2_Missense_Mutation_p.E286Q	NM_002810	NP_002801	P55036	PSMD4_HUMAN	proteasome 26S non-ATPase subunit 4	283	UIM 2.				anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA repair|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|regulation of transcription, DNA-dependent|S phase of mitotic cell cycle|viral reproduction	proteasome complex	protein binding|zinc ion binding				0	Lung SC(34;0.00471)|Ovarian(49;0.0147)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)			CAGTATGACTGAGGAAGAGCA	0.552		NaN											0	0	0	0.013537	0	12	99									
FLG	2312	broad.mit.edu	37	1	152275618	152275618	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr1:152275618G>C	uc001ezu.1	-	3	11780	c.11744C>G	c.(11743-11745)TCT>TGT	p.S3915C		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	3915	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TACAGGTGAAGACTGTACATG	0.498		NaN							Ichthyosis				0	0	0	0.001984	0	5	101									
IQGAP3	128239	broad.mit.edu	37	1	156507074	156507074	+	Silent	SNP	G	G	A			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr1:156507074G>A	uc001fpf.2	-	27	3396	c.3321C>T	c.(3319-3321)AGC>AGT	p.S1107S		NM_178229	NP_839943	Q86VI3	IQGA3_HUMAN	IQ motif containing GTPase activating protein 3	1107	Ras-GAP.				small GTPase mediated signal transduction	intracellular	calmodulin binding|Ras GTPase activator activity			ovary(5)|skin(1)	6	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					CCTCGGGGTGGCTCAAGGCCT	0.562		NaN											0	0	0	0.004672	0	3	36									
PBX1	5087	broad.mit.edu	37	1	164761814	164761814	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr1:164761814G>A	uc001gct.2	+	3	607	c.349G>A	c.(349-351)GTG>ATG	p.V117M	PBX1_uc010pku.1_Missense_Mutation_p.V117M|PBX1_uc010pkv.1_Missense_Mutation_p.V34M|PBX1_uc001gcs.2_Missense_Mutation_p.V117M|PBX1_uc010pkw.1_Missense_Mutation_p.V7M	NM_002585	NP_002576	P40424	PBX1_HUMAN	pre-B-cell leukemia homeobox 1	117					negative regulation of sequence-specific DNA binding transcription factor activity|sex differentiation|steroid biosynthetic process	cytoplasm|nucleus	sequence-specific DNA binding transcription factor activity|transcription factor binding		EWSR1/PBX1(3)	soft_tissue(3)|lung(1)|skin(1)	5						AGCGGAAGGCGTGGCGGGGCC	0.493		NaN	T	TCF3|EWSR1	pre B-ALL|myoepithelioma								0	0	0	0.004672	0	3	18									
PM20D1	148811	broad.mit.edu	37	1	205819093	205819093	+	Silent	SNP	C	C	T			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr1:205819093C>T	uc001hdj.2	-	1	153	c.108G>A	c.(106-108)GCG>GCA	p.A36A	PM20D1_uc009xbr.2_RNA	NM_152491	NP_689704	Q6GTS8	P20D1_HUMAN	peptidase M20 domain containing 1 precursor	36						extracellular region	metal ion binding|peptidase activity			skin(1)	1	Breast(84;0.201)		BRCA - Breast invasive adenocarcinoma(75;0.0252)			GGATTCGCGACGCCCTTTGAT	0.592		NaN											0	0	0	0.014758	0	5	58									
LAMB3	3914	broad.mit.edu	37	1	209789846	209789846	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr1:209789846C>T	uc001hhg.2	-	21	3742	c.3352G>A	c.(3352-3354)GAG>AAG	p.E1118K	LAMB3_uc009xco.2_Missense_Mutation_p.E1118K|LAMB3_uc001hhh.2_Missense_Mutation_p.E1118K	NM_001017402	NP_001017402	Q13751	LAMB3_HUMAN	laminin, beta 3 precursor	1118	Domain I.|Potential.				cell adhesion|epidermis development|hemidesmosome assembly		structural molecule activity			central_nervous_system(2)|skin(2)|large_intestine(1)|ovary(1)	6				OV - Ovarian serous cystadenocarcinoma(81;0.0519)		TCCATGGTCTCCCCAAACAGC	0.552		NaN											0	0	0	0.013537	0	9	183									
KCNK2	3776	broad.mit.edu	37	1	215256745	215256745	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr1:215256745C>T	uc001hkq.2	+	1	186	c.17C>T	c.(16-18)TCG>TTG	p.S6L	KCNK2_uc001hko.2_Intron|KCNK2_uc009xdm.2_Intron|KCNK2_uc001hkp.2_Intron|KCNK2_uc010pua.1_RNA|KCNK2_uc001hkr.3_Intron	NM_001017425	NP_001017425	O95069	KCNK2_HUMAN	potassium channel, subfamily K, member 2 isoform	6	Cytoplasmic (Potential).						outward rectifier potassium channel activity				0				OV - Ovarian serous cystadenocarcinoma(81;0.0399)|all cancers(67;0.0556)|GBM - Glioblastoma multiforme(131;0.068)	Dofetilide(DB00204)	CCCAGCGCCTCGCGGGAGAGA	0.547		NaN											0	0	0	0.008291	0	9	79									
ATAD1	84896	broad.mit.edu	37	10	89516664	89516664	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr10:89516664C>G	uc001key.1	-	8	1130	c.847G>C	c.(847-849)GAC>CAC	p.D283H	ATAD1_uc010qmr.1_Missense_Mutation_p.D195H|ATAD1_uc009xth.1_RNA|ATAD1_uc001kez.1_Missense_Mutation_p.D283H	NM_032810	NP_116199	Q8NBU5	ATAD1_HUMAN	ATPase family, AAA domain containing 1	283						peroxisome	ATP binding|nucleoside-triphosphatase activity			large_intestine(1)|ovary(1)	2		all_cancers(4;6.78e-12)|Prostate(4;3.56e-12)|all_epithelial(4;5.58e-09)|Melanoma(5;0.0273)|Breast(4;0.0424)|all_hematologic(4;0.0846)|Colorectal(252;0.207)|Glioma(4;0.217)|all_neural(4;0.224)		UCEC - Uterine corpus endometrioid carcinoma (6;0.00131)|GBM - Glioblastoma multiforme(1;1.1e-32)|Lung(2;1.4e-05)|LUSC - Lung squamous cell carcinoma(2;2.69e-05)|Colorectal(12;7.09e-05)|COAD - Colon adenocarcinoma(12;0.000261)|STAD - Stomach adenocarcinoma(243;0.235)		TCTAGCAGGTCTACATGCCTA	0.353		NaN											0	0	0	0.021553	0	6	99									
MYOF	26509	broad.mit.edu	37	10	95147619	95147619	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr10:95147619G>A	uc001kin.2	-	19	1756	c.1633C>T	c.(1633-1635)CTT>TTT	p.L545F	MYOF_uc001kio.2_Missense_Mutation_p.L532F	NM_013451	NP_038479	Q9NZM1	MYOF_HUMAN	myoferlin isoform a	545	Cytoplasmic (Potential).				blood circulation|muscle contraction|plasma membrane repair	caveola|cytoplasmic vesicle membrane|integral to membrane|nuclear membrane	phospholipid binding|protein binding			ovary(3)|breast(1)	4						GTCTTCTCAAGAAAAGTGGCT	0.423		NaN											0	0	0	0.00308	0	6	166									
ARHGAP19	84986	broad.mit.edu	37	10	99025847	99025847	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr10:99025847G>C	uc001knb.2	-	2	121	c.92C>G	c.(91-93)TCT>TGT	p.S31C	ARHGAP19_uc001kmy.2_RNA|ARHGAP19_uc001kna.2_Missense_Mutation_p.S22C|ARHGAP19_uc009xvi.2_RNA|ARHGAP19_uc009xvj.2_Missense_Mutation_p.S31C|ARHGAP19_uc009xvk.2_Intron	NM_032900	NP_116289	Q14CB8	RHG19_HUMAN	Rho GTPase activating protein 19	31					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|nucleus	GTPase activator activity				0		Colorectal(252;0.0854)		Epithelial(162;7.65e-09)|all cancers(201;4.49e-07)		TCGAAGGGAAGAATCATTGCA	0.393		NaN											0	0	0	0.014758	0	5	84									
CHUK	1147	broad.mit.edu	37	10	101978578	101978578	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr10:101978578C>T	uc001kqp.2	-	8	749	c.694G>A	c.(694-696)GAG>AAG	p.E232K		NM_001278	NP_001269	O15111	IKKA_HUMAN	conserved helix-loop-helix ubiquitous kinase	232	Protein kinase.				I-kappaB phosphorylation|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	CD40 receptor complex|cytosol|internal side of plasma membrane|nucleus	ATP binding|identical protein binding|IkappaB kinase activity			ovary(2)|central_nervous_system(2)|large_intestine(1)|lung(1)|breast(1)	7		Colorectal(252;0.117)		Epithelial(162;2.05e-10)|all cancers(201;1.91e-08)		TTAATCTTCTCATGCCTATAA	0.328		NaN											0	0	0	0.00308	0	8	93									
OR52I2	143502	broad.mit.edu	37	11	4608745	4608745	+	Missense_Mutation	SNP	C	C	T	rs137965376	byFrequency	TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr11:4608745C>T	uc010qyh.1	+	1	703	c.703C>T	c.(703-705)CTT>TTT	p.L235F		NM_001005170	NP_001005170	Q8NH67	O52I2_HUMAN	olfactory receptor, family 52, subfamily I,	235	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(1)	1		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;8.45e-12)|BRCA - Breast invasive adenocarcinoma(625;0.0285)|LUSC - Lung squamous cell carcinoma(625;0.19)		TGGTTCCTCTCTTATGGTGGG	0.488		NaN											0	0	0	0.010504	0	19	257									
DEPDC7	91614	broad.mit.edu	37	11	33053051	33053051	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr11:33053051G>C	uc001mub.2	+	5	1002	c.910G>C	c.(910-912)GAT>CAT	p.D304H	DEPDC7_uc001muc.2_Missense_Mutation_p.D295H	NM_001077242	NP_001070710	Q96QD5	DEPD7_HUMAN	novel 58.3 KDA protein isoform 1	304					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			ovary(1)|skin(1)	2						ACTTCTGTTTGATGCCATTGG	0.398		NaN											0	0	0	0.024245	0	10	124									
DEPDC7	91614	broad.mit.edu	37	11	33053080	33053080	+	Silent	SNP	G	G	A			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr11:33053080G>A	uc001mub.2	+	5	1031	c.939G>A	c.(937-939)AGG>AGA	p.R313R	DEPDC7_uc001muc.2_Silent_p.R304R	NM_001077242	NP_001070710	Q96QD5	DEPD7_HUMAN	novel 58.3 KDA protein isoform 1	313					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			ovary(1)|skin(1)	2						ACAGTAGTAGGGAACCTCTGT	0.393		NaN											0	0	0	0.008291	0	7	129									
DEPDC7	91614	broad.mit.edu	37	11	33054239	33054239	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr11:33054239G>C	uc001mub.2	+	7	1255	c.1163G>C	c.(1162-1164)AGG>ACG	p.R388T	DEPDC7_uc001muc.2_Missense_Mutation_p.R379T	NM_001077242	NP_001070710	Q96QD5	DEPD7_HUMAN	novel 58.3 KDA protein isoform 1	388					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			ovary(1)|skin(1)	2						GTTGTGAAAAGGATATTCTCA	0.259		NaN											0	0	0	0.024245	0	16	106									
DEPDC7	91614	broad.mit.edu	37	11	33054490	33054490	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr11:33054490G>A	uc001mub.2	+	8	1411	c.1319G>A	c.(1318-1320)GGA>GAA	p.G440E	DEPDC7_uc001muc.2_Missense_Mutation_p.G431E	NM_001077242	NP_001070710	Q96QD5	DEPD7_HUMAN	novel 58.3 KDA protein isoform 1	440					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			ovary(1)|skin(1)	2						ATACAGAACGGAAGAGATCCA	0.318		NaN											0	0	0	0.008871	0	17	119									
DEPDC7	91614	broad.mit.edu	37	11	33054924	33054924	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr11:33054924G>A	uc001mub.2	+	9	1551	c.1459G>A	c.(1459-1461)GCC>ACC	p.A487T	DEPDC7_uc001muc.2_Missense_Mutation_p.A478T	NM_001077242	NP_001070710	Q96QD5	DEPD7_HUMAN	novel 58.3 KDA protein isoform 1	487					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			ovary(1)|skin(1)	2						AAAACTTTCTGCCAAAGAGAA	0.333		NaN											0	0	0	0.001984	0	6	140									
NAT10	55226	broad.mit.edu	37	11	34139781	34139781	+	Silent	SNP	C	C	G			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr11:34139781C>G	uc001mvk.2	+	7	856	c.612C>G	c.(610-612)CTC>CTG	p.L204L	NAT10_uc010ren.1_Silent_p.L132L	NM_024662	NP_078938	Q9H0A0	NAT10_HUMAN	N-acetyltransferase 10 isoform a	204						nucleolus	ATP binding|N-acetyltransferase activity|protein binding			ovary(1)|skin(1)	2		Acute lymphoblastic leukemia(5;0.0119)|all_hematologic(20;0.0231)				ATGACCAGCTCAACATCCTGC	0.557		NaN											0	0	0	0.016723	0	10	60									
PGM2L1	283209	broad.mit.edu	37	11	74056622	74056622	+	Silent	SNP	C	C	T			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr11:74056622C>T	uc001ovb.1	-	9	1406	c.1110G>A	c.(1108-1110)AAG>AAA	p.K370K		NM_173582	NP_775853	Q6PCE3	PGM2L_HUMAN	phosphoglucomutase 2-like 1	370					glucose 1-phosphate metabolic process	cytosol	glucose-1,6-bisphosphate synthase activity|phosphoglucomutase activity			ovary(1)	1	Breast(11;3.32e-06)					ATTTATTTTTCTTCCAGCAAT	0.373		NaN											0	0	0	0.021553	0	5	108									
MAP6	4135	broad.mit.edu	37	11	75298367	75298367	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr11:75298367G>C	uc001owu.2	-	4	2244	c.2179C>G	c.(2179-2181)CAA>GAA	p.Q727E		NM_033063	NP_149052	Q96JE9	MAP6_HUMAN	microtubule-associated protein 6 isoform 1	727	Pro-rich.					Golgi apparatus|microtubule|perinuclear region of cytoplasm	calmodulin binding				0	Ovarian(111;0.11)					GTGGGGCCTTGATCCTTAACT	0.493		NaN											0	0	0	0.01892	0	25	221									
TSKU	25987	broad.mit.edu	37	11	76507357	76507357	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr11:76507357C>T	uc001oxt.2	+	2	869	c.697C>T	c.(697-699)CAC>TAC	p.H233Y		NM_015516	NP_056331	Q8WUA8	TSK_HUMAN	tsukushin precursor	233	LRR 8.					extracellular region					0	Ovarian(111;0.112)					AGGCCTTACACACCTGTCTCT	0.667		NaN											0	0	0	0.004482	0	8	112									
NPAT	4863	broad.mit.edu	37	11	108043955	108043955	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr11:108043955C>T	uc001pjz.3	-	13	1858	c.1756G>A	c.(1756-1758)GAA>AAA	p.E586K	NPAT_uc001pka.2_Missense_Mutation_p.E381K	NM_002519	NP_002510	Q14207	NPAT_HUMAN	nuclear protein,  ataxia-telangiectasia locus	586					positive regulation of transcription, DNA-dependent|regulation of transcription involved in G1/S phase of mitotic cell cycle	Cajal body	protein C-terminus binding|protein N-terminus binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity			ovary(2)	2		all_cancers(61;2.31e-10)|all_epithelial(67;1.11e-06)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		BRCA - Breast invasive adenocarcinoma(274;1.05e-05)|Epithelial(105;3.01e-05)|all cancers(92;0.000816)|Colorectal(284;0.116)		ATAACTGGTTCTAACACATTA	0.299		NaN											0	0	0	0.020292	0	14	231									
EXPH5	23086	broad.mit.edu	37	11	108382830	108382830	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr11:108382830C>A	uc001pkk.2	-	6	3515	c.3404G>T	c.(3403-3405)GGA>GTA	p.G1135V	EXPH5_uc010rvy.1_Missense_Mutation_p.G947V|EXPH5_uc010rvz.1_Missense_Mutation_p.G979V|EXPH5_uc010rwa.1_Missense_Mutation_p.G1059V	NM_015065	NP_055880	Q8NEV8	EXPH5_HUMAN	exophilin 5 isoform a	1135					intracellular protein transport		Rab GTPase binding			skin(3)|ovary(2)	5		all_cancers(61;3.99e-08)|Acute lymphoblastic leukemia(157;3.97e-05)|Melanoma(852;4.04e-05)|all_epithelial(67;0.000116)|all_hematologic(158;0.000315)|Breast(348;0.104)|all_neural(303;0.16)		Epithelial(105;8.1e-06)|BRCA - Breast invasive adenocarcinoma(274;1.22e-05)|all cancers(92;0.000129)|OV - Ovarian serous cystadenocarcinoma(223;0.11)|Colorectal(284;0.184)		TCCTTCTCTTCCAGTTGAGGC	0.483		NaN											1	0	7.48243e-07	0.006214	8.30922e-07	8	129									
A2ML1	144568	broad.mit.edu	37	12	9020914	9020914	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr12:9020914C>A	uc001quz.3	+	31	4120	c.4022C>A	c.(4021-4023)CCG>CAG	p.P1341Q	A2ML1_uc001qva.1_Missense_Mutation_p.P921Q|A2ML1_uc010sgm.1_Missense_Mutation_p.P841Q|A2ML1_uc001qvb.1_RNA	NM_144670	NP_653271	A8K2U0	A2ML1_HUMAN	alpha-2-macroglobulin-like 1 precursor	1185						extracellular space	endopeptidase inhibitor activity			ovary(2)|skin(1)	3						TGTGAGCAACCGACTTCACCT	0.488		NaN											1	0	1.15088e-07	0.028581	1.29233e-07	17	254									
STYK1	55359	broad.mit.edu	37	12	10780303	10780303	+	Silent	SNP	A	A	C			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr12:10780303A>C	uc001qys.2	-	7	1175	c.654T>G	c.(652-654)GGT>GGG	p.G218G		NM_018423	NP_060893	Q6J9G0	STYK1_HUMAN	serine/threonine/tyrosine kinase 1	218	Protein kinase.					integral to membrane|plasma membrane	ATP binding|non-membrane spanning protein tyrosine kinase activity			central_nervous_system(3)|ovary(2)|lung(2)|breast(1)	8						CATAGAGAAGACCATCCATAG	0.398		NaN								HNSCC(73;0.22)			0	0	0	0.016723	0	9	72									
TAS2R9	50835	broad.mit.edu	37	12	10962188	10962188	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr12:10962188C>G	uc001qyx.2	-	1	580	c.487G>C	c.(487-489)GAA>CAA	p.E163Q	TAS2R8_uc010shh.1_5'Flank	NM_023917	NP_076406	Q9NYW1	TA2R9_HUMAN	taste receptor, type 2, member 9	163	Extracellular (Potential).				sensory perception of taste	integral to membrane	taste receptor activity			skin(1)	1						GTAATGTTTTCTTCATGACTG	0.378		NaN											0	0	0	0.016723	0	12	107									
CMAS	55907	broad.mit.edu	37	12	22208488	22208488	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr12:22208488C>G	uc001rfm.2	+	3	582	c.503C>G	c.(502-504)TCT>TGT	p.S168C	CMAS_uc001rfn.2_RNA	NM_018686	NP_061156	Q8NFW8	NEUA_HUMAN	cytidine monophospho-N-acetylneuraminic acid	168					lipopolysaccharide biosynthetic process	nucleus	N-acylneuraminate cytidylyltransferase activity			ovary(1)|pancreas(1)|skin(1)	3						GGATATGATTCTGTTTTCTCT	0.353		NaN											0	0	0	0.001984	0	7	114									
ACVRL1	94	broad.mit.edu	37	12	52309201	52309201	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr12:52309201G>A	uc001rzj.2	+	7	1248	c.965G>A	c.(964-966)GGC>GAC	p.G322D	ACVRL1_uc001rzk.2_Missense_Mutation_p.G322D|ACVRL1_uc010snm.1_Missense_Mutation_p.G148D	NM_000020	NP_000011	P37023	ACVL1_HUMAN	activin A receptor type II-like 1 precursor	322	Cytoplasmic (Potential).|Protein kinase.				blood vessel endothelial cell proliferation involved in sprouting angiogenesis|blood vessel maturation|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of endothelial cell migration|negative regulation of focal adhesion assembly|positive regulation of BMP signaling pathway|positive regulation of transcription, DNA-dependent|regulation of blood pressure|regulation of blood vessel endothelial cell migration|regulation of DNA replication|regulation of endothelial cell proliferation|transforming growth factor beta receptor signaling pathway|wound healing, spreading of epidermal cells	cell surface|integral to plasma membrane	activin binding|activin receptor activity, type I|ATP binding|metal ion binding|receptor signaling protein serine/threonine kinase activity|SMAD binding|transforming growth factor beta binding|transforming growth factor beta receptor activity			lung(2)	2				BRCA - Breast invasive adenocarcinoma(357;0.0991)	Adenosine triphosphate(DB00171)	GGTACACAGGGCAAACCAGCC	0.642		NaN							Hereditary_Hemorrhagic_Telangiectasia				0	0	0	0.014758	0	3	25									
GRASP	160622	broad.mit.edu	37	12	52404711	52404711	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr12:52404711G>C	uc001rzo.1	+	3	399	c.343G>C	c.(343-345)GAG>CAG	p.E115Q	GRASP_uc001rzp.1_5'UTR	NM_181711	NP_859062	Q7Z6J2	GRASP_HUMAN	GRP1 (general receptor for phosphoinositides	115	PDZ.					cell junction|perinuclear region of cytoplasm|postsynaptic membrane				central_nervous_system(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(357;0.0967)		CTTCGGCTTTGAGATCCAGGT	0.547		NaN											0	0	0	0.010729	0	11	134									
ESPL1	9700	broad.mit.edu	37	12	53662888	53662888	+	Silent	SNP	G	G	A			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr12:53662888G>A	uc001sck.2	+	3	253	c.162G>A	c.(160-162)CTG>CTA	p.L54L	ESPL1_uc001scj.2_5'UTR	NM_012291	NP_036423	Q14674	ESPL1_HUMAN	separase	54					apoptosis|cytokinesis|establishment of mitotic spindle localization|mitotic sister chromatid segregation|negative regulation of sister chromatid cohesion|positive regulation of mitotic metaphase/anaphase transition|proteolysis	centrosome|nucleus	cysteine-type peptidase activity|protein binding			lung(1)|kidney(1)|skin(1)	3						ATGCCATCCTGAGGGCTTGCA	0.552		NaN											0	0	0	0.001984	0	6	91									
NCKAP1L	3071	broad.mit.edu	37	12	54894397	54894397	+	Silent	SNP	C	C	T			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr12:54894397C>T	uc001sgc.3	+	3	373	c.294C>T	c.(292-294)GTC>GTT	p.V98V	NCKAP1L_uc010sox.1_5'UTR|NCKAP1L_uc010soy.1_Silent_p.V48V	NM_005337	NP_005328	P55160	NCKPL_HUMAN	NCK-associated protein 1-like	98					actin polymerization-dependent cell motility|B cell homeostasis|B cell receptor signaling pathway|cortical actin cytoskeleton organization|erythrocyte development|maintenance of cell polarity|myeloid cell homeostasis|negative regulation of apoptosis|negative regulation of interleukin-17 production|negative regulation of interleukin-6 production|negative regulation of myosin-light-chain-phosphatase activity|neutrophil chemotaxis|positive regulation of actin filament polymerization|positive regulation of B cell differentiation|positive regulation of B cell proliferation|positive regulation of CD4-positive, alpha-beta T cell differentiation|positive regulation of CD8-positive, alpha-beta T cell differentiation|positive regulation of cell adhesion mediated by integrin|positive regulation of erythrocyte differentiation|positive regulation of gamma-delta T cell differentiation|positive regulation of neutrophil chemotaxis|positive regulation of phagocytosis, engulfment|positive regulation of T cell proliferation|protein complex assembly|response to drug|T cell homeostasis	cytosol|integral to plasma membrane|membrane fraction|SCAR complex	protein complex binding|protein kinase activator activity|Rac GTPase activator activity			ovary(3)|central_nervous_system(1)	4						TTGTGGATGTCATGGAATTTC	0.398		NaN											0	0	0	0.016723	0	13	181									
NCKAP1L	3071	broad.mit.edu	37	12	54912718	54912718	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr12:54912718G>C	uc001sgc.3	+	15	1520	c.1441G>C	c.(1441-1443)GAA>CAA	p.E481Q	NCKAP1L_uc010sox.1_Missense_Mutation_p.E23Q|NCKAP1L_uc010soy.1_Missense_Mutation_p.E431Q	NM_005337	NP_005328	P55160	NCKPL_HUMAN	NCK-associated protein 1-like	481					actin polymerization-dependent cell motility|B cell homeostasis|B cell receptor signaling pathway|cortical actin cytoskeleton organization|erythrocyte development|maintenance of cell polarity|myeloid cell homeostasis|negative regulation of apoptosis|negative regulation of interleukin-17 production|negative regulation of interleukin-6 production|negative regulation of myosin-light-chain-phosphatase activity|neutrophil chemotaxis|positive regulation of actin filament polymerization|positive regulation of B cell differentiation|positive regulation of B cell proliferation|positive regulation of CD4-positive, alpha-beta T cell differentiation|positive regulation of CD8-positive, alpha-beta T cell differentiation|positive regulation of cell adhesion mediated by integrin|positive regulation of erythrocyte differentiation|positive regulation of gamma-delta T cell differentiation|positive regulation of neutrophil chemotaxis|positive regulation of phagocytosis, engulfment|positive regulation of T cell proliferation|protein complex assembly|response to drug|T cell homeostasis	cytosol|integral to plasma membrane|membrane fraction|SCAR complex	protein complex binding|protein kinase activator activity|Rac GTPase activator activity			ovary(3)|central_nervous_system(1)	4						AGAAAAATTTGAATTCTCAGG	0.403		NaN											0	0	0	0.004482	0	8	72									
C12orf66	144577	broad.mit.edu	37	12	64587993	64587993	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr12:64587993C>T	uc001srw.3	-	3	1026	c.967G>A	c.(967-969)GAG>AAG	p.E323K	C12orf66_uc009zql.2_Missense_Mutation_p.E270K	NM_152440	NP_689653	Q96MD2	CL066_HUMAN	hypothetical protein LOC144577	323										ovary(1)	1						TGAAAACTCTCAGAACCTCTG	0.473		NaN											0	0	0	0.016723	0	12	174									
C12orf66	144577	broad.mit.edu	37	12	64588249	64588249	+	Silent	SNP	C	C	T			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr12:64588249C>T	uc001srw.3	-	3	770	c.711G>A	c.(709-711)AAG>AAA	p.K237K	C12orf66_uc009zql.2_Silent_p.K184K	NM_152440	NP_689653	Q96MD2	CL066_HUMAN	hypothetical protein LOC144577	237										ovary(1)	1						ACAGATGTTTCTTGGTCTCCC	0.493		NaN											0	0	0	0.004482	0	8	66									
DNAH10	196385	broad.mit.edu	37	12	124362399	124362399	+	Silent	SNP	C	C	T			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr12:124362399C>T	uc001uft.3	+	47	7987	c.7962C>T	c.(7960-7962)TTC>TTT	p.F2654F		NM_207437	NP_997320	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	2654	AAA 3 (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(3)|skin(2)|central_nervous_system(1)	6	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		ATTACATCTTCAACCTTCGAG	0.443		NaN											0	0	0	0.007413	0	18	259									
DNAJC3	5611	broad.mit.edu	37	13	96409943	96409943	+	Nonsense_Mutation	SNP	C	C	T			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr13:96409943C>T	uc001vmq.2	+	5	547	c.439C>T	c.(439-441)CAA>TAA	p.Q147*	DNAJC3_uc001vmr.2_Intron	NM_006260	NP_006251	Q13217	DNJC3_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 3	147					protein folding|response to unfolded protein|response to virus		heat shock protein binding|protein kinase inhibitor activity|unfolded protein binding				0	all_neural(89;0.0878)|Breast(111;0.148)|Medulloblastoma(90;0.163)		BRCA - Breast invasive adenocarcinoma(86;0.126)			AGCACAGTCTCAACTTATAAA	0.343		NaN											0	0	0	0.004482	0	9	90									
OR4K1	79544	broad.mit.edu	37	14	20404396	20404396	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr14:20404396G>A	uc001vwj.1	+	1	571	c.571G>A	c.(571-573)GAT>AAT	p.D191N		NM_001004063	NP_001004063	Q8NGD4	OR4K1_HUMAN	olfactory receptor, family 4, subfamily K,	191	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)	3	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00124)		GGCTTGCATGGATACATATGA	0.443		NaN											0	0	0	0.014758	0	5	327									
MIA2	117153	broad.mit.edu	37	14	39716635	39716635	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr14:39716635C>T	uc001wux.2	+	4	1051	c.857C>T	c.(856-858)TCA>TTA	p.S286L	MIA2_uc010amy.1_Missense_Mutation_p.S217L	NM_054024	NP_473365	Q96PC5	MIA2_HUMAN	melanoma inhibitory activity 2	286						extracellular region				ovary(1)|breast(1)	2	Hepatocellular(127;0.213)		LUAD - Lung adenocarcinoma(48;0.000565)|Lung(238;0.000711)	GBM - Glioblastoma multiforme(112;0.0216)		GAAATTGATTCAGTGCCAAAG	0.398		NaN											0	0	0	0.001984	0	7	91									
FANCM	57697	broad.mit.edu	37	14	45658433	45658433	+	Silent	SNP	G	G	C			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr14:45658433G>C	uc001wwd.3	+	20	5307	c.5208G>C	c.(5206-5208)CTG>CTC	p.L1736L	FANCM_uc010anf.2_Silent_p.L1710L|FANCM_uc001wwe.3_Silent_p.L1272L|FANCM_uc010ang.2_Silent_p.L950L	NM_020937	NP_065988	Q8IYD8	FANCM_HUMAN	Fanconi anemia, complementation group M	1736	Interaction with FAAP24 and EME1.				DNA repair	Fanconi anaemia nuclear complex	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding|nuclease activity|protein binding			ovary(3)|lung(2)|breast(2)	7						AGACATCGCTGAATTTAAAGG	0.418		NaN						Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				0	0	0	0.010504	0	19	237									
POLE2	5427	broad.mit.edu	37	14	50118050	50118050	+	Silent	SNP	T	T	C			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr14:50118050T>C	uc001wwu.2	-	16	1271	c.1257A>G	c.(1255-1257)TTA>TTG	p.L419L	SDCCAG1_uc010anj.1_Intron|POLE2_uc010ann.2_Silent_p.L133L|POLE2_uc001wwv.2_RNA|POLE2_uc010ano.2_Silent_p.L134L	NM_002692	NP_002683	P56282	DPOE2_HUMAN	DNA-directed DNA polymerase epsilon 2	419					DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	nucleoplasm	DNA binding|DNA-directed DNA polymerase activity			ovary(1)|skin(1)	2	all_epithelial(31;0.0021)|Breast(41;0.0124)					TTTTATTTACTAAGTCTTCAC	0.323		NaN											0	0	0	0.021553	0	5	66									
PLEKHG3	26030	broad.mit.edu	37	14	65198166	65198166	+	Missense_Mutation	SNP	C	C	T	rs145887123		TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr14:65198166C>T	uc001xho.1	+	8	1206	c.937C>T	c.(937-939)CGC>TGC	p.R313C	PLEKHG3_uc001xhn.1_Missense_Mutation_p.R257C|PLEKHG3_uc001xhp.2_Missense_Mutation_p.R313C|PLEKHG3_uc010aqh.1_5'UTR	NM_015549	NP_056364	A1L390	PKHG3_HUMAN	pleckstrin homology domain containing, family G,	313	PH.				regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			skin(1)	1				all cancers(60;0.00802)|OV - Ovarian serous cystadenocarcinoma(108;0.0109)|BRCA - Breast invasive adenocarcinoma(234;0.0485)		CCGCGTGCATCGCGTGCGCAA	0.552		NaN											0	0	0	0.014758	0	5	67									
NUDT14	256281	broad.mit.edu	37	14	105639498	105639498	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr14:105639498C>T	uc010tyn.1	-	5	643	c.529G>A	c.(529-531)GAG>AAG	p.E177K	NUDT14_uc001yqi.2_RNA	NM_177533	NP_803877	O95848	NUD14_HUMAN	nudix-type motif 14	177	Nudix hydrolase.					cytoplasm	metal ion binding|protein binding|UDP-sugar diphosphatase activity			skin(1)	1		all_cancers(154;0.0336)|all_epithelial(191;0.0729)|Melanoma(154;0.155)	OV - Ovarian serous cystadenocarcinoma(23;0.00989)|all cancers(16;0.0114)|Epithelial(46;0.0272)	Epithelial(152;0.047)|OV - Ovarian serous cystadenocarcinoma(161;0.148)|all cancers(159;0.208)		TCAATGAGCTCACCCTCCTCC	0.622		NaN								HNSCC(42;0.11)			0	0	0	0.009096	0	4	34									
CEP152	22995	broad.mit.edu	37	15	49076285	49076285	+	Silent	SNP	C	C	T			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr15:49076285C>T	uc001zwy.2	-	10	1240	c.1206G>A	c.(1204-1206)GTG>GTA	p.V402V	CEP152_uc001zwz.2_Silent_p.V402V|CEP152_uc001zxa.1_Silent_p.V309V	NM_014985	NP_055800	O94986	CE152_HUMAN	centrosomal protein 152kDa	402	Potential.				centrosome duplication|G2/M transition of mitotic cell cycle	centrosome|cytosol	protein kinase binding			lung(2)	2		all_lung(180;0.0428)		all cancers(107;1.08e-07)|GBM - Glioblastoma multiforme(94;2.32e-06)		CCAGTTGTTTCACGTGATCTT	0.333		NaN											0	0	0	0.021553	0	5	66									
ZNF609	23060	broad.mit.edu	37	15	64968069	64968069	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr15:64968069G>A	uc002ann.2	+	4	3016	c.3016G>A	c.(3016-3018)GAA>AAA	p.E1006K		NM_015042	NP_055857	O15014	ZN609_HUMAN	zinc finger protein 609	1006						nucleus	zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	3						GCAGCAGTACGAAGAACAGCA	0.562		NaN											0	0	0	0.014758	0	4	115									
CORO2B	10391	broad.mit.edu	37	15	69018260	69018260	+	Missense_Mutation	SNP	C	C	T	rs146678597		TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr15:69018260C>T	uc002arj.3	+	12	1419	c.1390C>T	c.(1390-1392)CGG>TGG	p.R464W	CORO2B_uc010bic.2_Missense_Mutation_p.R459W|CORO2B_uc002ark.2_Missense_Mutation_p.R231W	NM_006091	NP_006082	Q9UQ03	COR2B_HUMAN	coronin, actin binding protein, 2B	464	Potential.				actin cytoskeleton organization	actin cytoskeleton|cytoplasm|membrane	actin filament binding			ovary(3)|skin(2)|large_intestine(1)	6						CATCCGCATTCGGCAGCTCCA	0.557		NaN											0	0	0	0.009096	0	4	52									
RLBP1	6017	broad.mit.edu	37	15	89758326	89758326	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr15:89758326C>G	uc002bnl.2	-	6	870	c.490G>C	c.(490-492)GAG>CAG	p.E164Q		NM_000326	NP_000317	P12271	RLBP1_HUMAN	retinaldehyde binding protein 1	164	CRAL-TRIO.				response to stimulus|visual perception|vitamin A metabolic process	cytoplasm|soluble fraction	retinol binding|transporter activity			central_nervous_system(1)	1	Lung NSC(78;0.0472)|all_lung(78;0.089)				Vitamin A(DB00162)	TGCCAGTTCTCAATGTTGAAG	0.577		NaN											0	0	0	0.00308	0	7	121									
GLYR1	84656	broad.mit.edu	37	16	4882060	4882060	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr16:4882060C>T	uc002cxx.3	-	5	494	c.457G>A	c.(457-459)GAG>AAG	p.E153K	GLYR1_uc002cxy.2_RNA|GLYR1_uc002cxz.1_Missense_Mutation_p.E84K|GLYR1_uc002cya.2_Missense_Mutation_p.E153K|GLYR1_uc010uxv.1_Intron	NM_032569	NP_115958	Q49A26	GLYR1_HUMAN	cytokine-like nuclear factor n-pac	153					pentose-phosphate shunt	nucleus	coenzyme binding|DNA binding|methylated histone residue binding|phosphogluconate dehydrogenase (decarboxylating) activity				0						GAGCCTCTCTCTGAAGAGCCT	0.527		NaN											0	0	0	0.010729	0	11	191									
ADAT1	23536	broad.mit.edu	37	16	75654613	75654613	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr16:75654613G>A	uc002feo.1	-	3	187	c.85C>T	c.(85-87)CAT>TAT	p.H29Y	ADAT1_uc002fep.1_5'UTR	NM_012091	NP_036223	Q9BUB4	ADAT1_HUMAN	adenosine deaminase, tRNA-specific 1	29					tRNA processing		metal ion binding|RNA binding|tRNA-specific adenosine deaminase activity			ovary(1)|skin(1)	2						GTCCACTCATGGTTTGGCTCA	0.522		NaN											0	0	0	0.021553	0	6	67									
KARS	3735	broad.mit.edu	37	16	75669620	75669620	+	Silent	SNP	G	G	T			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr16:75669620G>T	uc002feq.2	-	6	801	c.753C>A	c.(751-753)ATC>ATA	p.I251I	KARS_uc002fer.2_Silent_p.I279I|KARS_uc002fes.2_Silent_p.I95I|KARS_uc010cgz.2_Silent_p.I95I	NM_005548	NP_005539	Q15046	SYK_HUMAN	lysyl-tRNA synthetase isoform 2	251					interspecies interaction between organisms|lysyl-tRNA aminoacylation|tRNA processing	cytosol|extracellular region|mitochondrial matrix|nucleus|plasma membrane|soluble fraction	ATP binding|lysine-tRNA ligase activity|metal ion binding|tRNA binding			ovary(2)	2					L-Lysine(DB00123)	TTATATATGTGATGATCTTAG	0.443		NaN											1	0	7.48243e-07	0.006214	8.30922e-07	9	81									
KARS	3735	broad.mit.edu	37	16	75669626	75669626	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr16:75669626C>G	uc002feq.2	-	6	795	c.747G>C	c.(745-747)AAG>AAC	p.K249N	KARS_uc002fer.2_Missense_Mutation_p.K277N|KARS_uc002fes.2_Missense_Mutation_p.K93N|KARS_uc010cgz.2_Missense_Mutation_p.K93N	NM_005548	NP_005539	Q15046	SYK_HUMAN	lysyl-tRNA synthetase isoform 2	249					interspecies interaction between organisms|lysyl-tRNA aminoacylation|tRNA processing	cytosol|extracellular region|mitochondrial matrix|nucleus|plasma membrane|soluble fraction	ATP binding|lysine-tRNA ligase activity|metal ion binding|tRNA binding			ovary(2)	2					L-Lysine(DB00123)	ATGTGATGATCTTAGAGCGGA	0.433		NaN											0	0	0	0.006214	0	9	88									
TAF1C	9013	broad.mit.edu	37	16	84214979	84214979	+	Silent	SNP	C	C	A			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr16:84214979C>A	uc002fhn.2	-	10	1425	c.1197G>T	c.(1195-1197)GTG>GTT	p.V399V	TAF1C_uc002fhm.2_Silent_p.V306V|TAF1C_uc010vnx.1_Silent_p.V373V|TAF1C_uc010vny.1_5'UTR|TAF1C_uc010vnz.1_Silent_p.V67V|TAF1C_uc002fho.2_5'UTR|TAF1C_uc010voa.1_Silent_p.V67V|TAF1C_uc002fhp.1_Intron|TAF1C_uc010vob.1_3'UTR	NM_005679	NP_005670	Q15572	TAF1C_HUMAN	TBP-associated factor 1C isoform 1	399					regulation of transcription, DNA-dependent|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase I promoter	nucleoplasm	DNA binding			ovary(1)	1						CCACGGTCAGCACCCGAGGGT	0.667		NaN											1	0	0.00116845	0.021553	0.00126267	6	12									
KCTD11	147040	broad.mit.edu	37	17	7256592	7256592	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr17:7256592C>G	uc002gge.3	+	1	1385	c.331C>G	c.(331-333)CAC>GAC	p.H111D	TMEM95_uc002ggf.1_5'Flank|TMEM95_uc002ggg.1_5'Flank|TMEM95_uc002ggh.1_5'Flank	NM_001002914	NP_001002914	Q693B1	KCD11_HUMAN	potassium channel tetramerisation domain	111					cell cycle|regulation of growth	voltage-gated potassium channel complex	voltage-gated potassium channel activity				0		Prostate(122;0.157)				GGGACCCCATCACTATGAGCT	0.632		NaN											0	0	0	0.001984	0	6	59									
PFAS	5198	broad.mit.edu	37	17	8168266	8168266	+	Silent	SNP	G	G	A			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr17:8168266G>A	uc002gkr.2	+	18	2244	c.2103G>A	c.(2101-2103)CTG>CTA	p.L701L	PFAS_uc010vuv.1_Silent_p.L277L|PFAS_uc002gks.2_5'Flank	NM_012393	NP_036525	O15067	PUR4_HUMAN	phosphoribosylformylglycinamidine synthase	701					'de novo' IMP biosynthetic process|glutamine metabolic process|purine base metabolic process	cytosol	ATP binding|phosphoribosylformylglycinamidine synthase activity|protein binding			ovary(2)|central_nervous_system(2)|pancreas(1)	5					L-Glutamic Acid(DB00142)|L-Glutamine(DB00130)	TGGGGCCCCTGCAAACTCCTC	0.632		NaN											0	0	0	0.004672	0	3	8									
CCL23	6368	broad.mit.edu	37	17	34344932	34344932	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr17:34344932C>T	uc002hkt.1	-	1	74	c.3G>A	c.(1-3)ATG>ATA	p.M1I	CCL23_uc002hks.1_Missense_Mutation_p.M1I	NM_145898	NP_665905	P55773	CCL23_HUMAN	small inducible cytokine A23 isoform CKbeta8	1					cell-cell signaling|cellular calcium ion homeostasis|chemotaxis|G-protein coupled receptor protein signaling pathway|immune response|inflammatory response|negative regulation of cell proliferation	extracellular space	chemokine activity|heparin binding				0		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)	Treprostinil(DB00374)	CGGAGACCTTCATCCTCCTGG	0.577		NaN											0	0	0	0.014758	0	4	28									
LRRC46	90506	broad.mit.edu	37	17	45912735	45912735	+	Missense_Mutation	SNP	T	T	C			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr17:45912735T>C	uc002ima.2	+	4	498	c.242T>C	c.(241-243)ATT>ACT	p.I81T	LRRC46_uc002imb.2_Missense_Mutation_p.I34T	NM_033413	NP_219481	Q96FV0	LRC46_HUMAN	leucine rich repeat containing 46	81	LRR 2.									ovary(1)	1						ATCCAGCAAATTGAGAACCTG	0.547		NaN											0	0	0	0.016522	0	21	195									
LRRC46	90506	broad.mit.edu	37	17	45913412	45913412	+	Silent	SNP	G	G	A			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr17:45913412G>A	uc002ima.2	+	6	652	c.396G>A	c.(394-396)CAG>CAA	p.Q132Q	LRRC46_uc002imb.2_Silent_p.Q85Q	NM_033413	NP_219481	Q96FV0	LRC46_HUMAN	leucine rich repeat containing 46	132	LRR 4.									ovary(1)	1						AGTTCCCCCAGAGCCTTCTCA	0.453		NaN											0	0	0	0.001984	0	7	58									
MSI2	124540	broad.mit.edu	37	17	55674294	55674294	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr17:55674294G>A	uc002iuz.1	+	8	693	c.520G>A	c.(520-522)GAA>AAA	p.E174K	MSI2_uc010wnm.1_Missense_Mutation_p.E152K|MSI2_uc002iva.2_Missense_Mutation_p.E170K	NM_138962	NP_620412	Q96DH6	MSI2H_HUMAN	musashi 2 isoform a	174	RRM 2.					cytoplasm	nucleotide binding|RNA binding			central_nervous_system(1)|pancreas(1)	2	Breast(9;1.78e-08)			GBM - Glioblastoma multiforme(1;0.0025)		TCATTTCCATGAAATCAATAA	0.418		NaN	T	HOXA9	CML								0	0	0	0.014758	0	5	113									
PPM1E	22843	broad.mit.edu	37	17	57058003	57058003	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr17:57058003C>A	uc002iwx.2	+	7	2006	c.1879C>A	c.(1879-1881)CCC>ACC	p.P627T	PPM1E_uc010ddd.2_Missense_Mutation_p.P390T	NM_014906	NP_055721	Q8WY54	PPM1E_HUMAN	protein phosphatase 1E	636					protein dephosphorylation	cytoplasm|nucleolus|protein serine/threonine phosphatase complex	metal ion binding|protein serine/threonine phosphatase activity			breast(3)|lung(1)|skin(1)	5	Medulloblastoma(34;0.127)|all_neural(34;0.237)		BRCA - Breast invasive adenocarcinoma(1;5.76e-11)			TGGAGAGTTTCCCACTGCTTT	0.428		NaN											1	0	0.000274275	0.004482	0.000301253	9	260									
MED13	9969	broad.mit.edu	37	17	60028354	60028354	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr17:60028354C>G	uc002izo.2	-	28	6200	c.6123G>C	c.(6121-6123)CAG>CAC	p.Q2041H		NM_005121	NP_005112	Q9UHV7	MED13_HUMAN	mediator complex subunit 13	2041					androgen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			large_intestine(1)|ovary(1)	2						GATCAGTACTCTGACCCTTAA	0.373		NaN											0	0	0	0.004482	0	7	98									
HELZ	9931	broad.mit.edu	37	17	65162678	65162678	+	Missense_Mutation	SNP	T	T	A			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr17:65162678T>A	uc010wqk.1	-	15	1998	c.1811A>T	c.(1810-1812)CAC>CTC	p.H604L	HELZ_uc002jfv.3_RNA|HELZ_uc002jfx.3_Missense_Mutation_p.H604L	NM_014877	NP_055692			helicase with zinc finger domain											ovary(1)|pancreas(1)	2	all_cancers(12;1.24e-11)|Breast(2;1.05e-17)|all_epithelial(3;3.87e-13)					TAGTGCATAGTGCATTTCACA	0.393		NaN											0	0	0	0.00308	0	7	154									
BPTF	2186	broad.mit.edu	37	17	65889808	65889808	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr17:65889808C>T	uc002jgf.2	+	6	2439	c.2378C>T	c.(2377-2379)TCA>TTA	p.S793L	BPTF_uc002jge.2_Missense_Mutation_p.S919L|BPTF_uc010wqm.1_Missense_Mutation_p.S856L	NM_182641	NP_872579	Q12830	BPTF_HUMAN	bromodomain PHD finger transcription factor	919	Interaction with MAZ.				brain development|chromatin remodeling|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|NURF complex	sequence-specific DNA binding|transcription factor binding|zinc ion binding			ovary(2)|skin(2)	4	all_cancers(12;6e-11)		BRCA - Breast invasive adenocarcinoma(8;7.48e-08)|Colorectal(3;0.0984)|LUSC - Lung squamous cell carcinoma(166;0.24)			AACATCCCTTCATCCTTTCTT	0.368		NaN											0	0	0	0.021553	0	4	93									
HGS	9146	broad.mit.edu	37	17	79660899	79660899	+	Splice_Site	SNP	G	G	T			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr17:79660899G>T	uc002kbg.2	+	11	918	c.841_splice	c.e11-1	p.R281_splice		NM_004712	NP_004703	O14964	HGS_HUMAN	hepatocyte growth factor-regulated tyrosine						cellular membrane organization|endosome transport|epidermal growth factor receptor signaling pathway|intracellular protein transport|negative regulation of cell proliferation|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of JAK-STAT cascade|regulation of protein catabolic process	cytosol|early endosome membrane|multivesicular body membrane	metal ion binding|protein domain specific binding			ovary(1)	1	all_neural(118;0.0878)|all_lung(278;0.23)		BRCA - Breast invasive adenocarcinoma(99;0.0101)|OV - Ovarian serous cystadenocarcinoma(97;0.0955)			TTCTGCCTCAGAGACAGAAGT	0.677		NaN											1	0	0.00909568	0.009096	0.00972464	4	38									
RNF125	54941	broad.mit.edu	37	18	29617078	29617078	+	Splice_Site	SNP	G	G	T			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr18:29617078G>T	uc002kxf.1	+	2	547	c.165_splice	c.e2-1	p.V55_splice		NM_017831	NP_060301	Q96EQ8	RN125_HUMAN	ring finger protein 125						negative regulation of type I interferon production	intracellular	ligase activity|zinc ion binding				0						GTTTGGGGTAGATTCTGCCGT	0.418		NaN											1	0	1.55469e-16	0.01892	1.7655e-16	23	371									
ZFR2	23217	broad.mit.edu	37	19	3819052	3819052	+	Missense_Mutation	SNP	T	T	C			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr19:3819052T>C	uc002lyw.2	-	12	1934	c.1922A>G	c.(1921-1923)GAC>GGC	p.D641G		NM_015174	NP_055989	Q9UPR6	ZFR2_HUMAN	zinc finger RNA binding protein 2 isoform 1	641						intracellular	nucleic acid binding|zinc ion binding			central_nervous_system(1)|pancreas(1)	2				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00514)|STAD - Stomach adenocarcinoma(1328;0.19)		CCTGCGCTTGTCACCCTCTTC	0.682		NaN											0	0	0	0.004672	0	2	6									
ZNF358	140467	broad.mit.edu	37	19	7584139	7584139	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr19:7584139C>T	uc002mgn.2	+	2	181	c.11C>T	c.(10-12)TCA>TTA	p.S4L		NM_018083	NP_060553	Q9NW07	ZN358_HUMAN	zinc finger protein 358	4					embryonic forelimb morphogenesis|neural tube development|regulation of transcription, DNA-dependent|stem cell maintenance|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)	1						ATGCGGCGCTCAGTCCTGGTC	0.597		NaN											0	0	0	0.021553	0	6	81									
ZNF491	126069	broad.mit.edu	37	19	11916920	11916920	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr19:11916920C>T	uc002mso.1	+	3	437	c.152C>T	c.(151-153)TCC>TTC	p.S51F		NM_152356	NP_689569	Q8N8L2	ZN491_HUMAN	zinc finger protein 491	51	C2H2-type 1; degenerate.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2						GGATATTCATCCTTTAATAGG	0.393		NaN											0	0	0	0.00308	0	6	111									
COPE	11316	broad.mit.edu	37	19	19021838	19021838	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr19:19021838C>T	uc002nkk.2	-	3	274	c.232G>A	c.(232-234)GCC>ACC	p.A78T	COPE_uc002nkl.2_Missense_Mutation_p.A78T|COPE_uc002nkm.2_Missense_Mutation_p.A78T|COPE_uc002nkn.2_Missense_Mutation_p.A78T|HOMER3_uc002nko.1_RNA|HOMER3_uc002nkp.1_Intron	NM_007263	NP_009194	O14579	COPE_HUMAN	epsilon subunit of coatomer protein complex	78					COPI coating of Golgi vesicle|intra-Golgi vesicle-mediated transport|protein transport|retrograde vesicle-mediated transport, Golgi to ER	COPI vesicle coat|cytosol	binding|structural molecule activity				0						AGCTCAGGGGCCGAGGAGGGC	0.632		NaN											0	0	0	0.004482	0	9	156									
ZNF429	353088	broad.mit.edu	37	19	21720336	21720336	+	Nonsense_Mutation	SNP	C	C	G			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr19:21720336C>G	uc002nqd.1	+	4	1618	c.1481C>G	c.(1480-1482)TCA>TGA	p.S494*	ZNF429_uc010ecu.1_Intron	NM_001001415	NP_001001415	Q86V71	ZN429_HUMAN	zinc finger protein 429	494	C2H2-type 13.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2						AAGCAGTCCTCAAACCTTAAC	0.398		NaN											0	0	0	0.004482	0	9	59									
ZNF429	353088	broad.mit.edu	37	19	21720683	21720683	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr19:21720683C>G	uc002nqd.1	+	4	1965	c.1828C>G	c.(1828-1830)CAA>GAA	p.Q610E	ZNF429_uc010ecu.1_Intron	NM_001001415	NP_001001415	Q86V71	ZN429_HUMAN	zinc finger protein 429	610	C2H2-type 17.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2						AAGACTTACTCAACATAAGAA	0.358		NaN											0	0	0	0.001984	0	7	99									
ERF	2077	broad.mit.edu	37	19	42754675	42754675	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr19:42754675G>C	uc002ote.3	-	2	223	c.65C>G	c.(64-66)CCT>CGT	p.P22R	ERF_uc002otd.3_5'UTR	NM_006494	NP_006485	P50548	ERF_HUMAN	Ets2 repressor factor	22					cell proliferation|regulation of transcription from RNA polymerase II promoter	nucleus	ligand-regulated transcription factor activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			lung(1)|kidney(1)|central_nervous_system(1)|skin(1)	4		Prostate(69;0.00682)				CCTTGAGCCAGGGGACGACTC	0.642		NaN											0	0	0	0.009096	0	4	37									
ZNF615	284370	broad.mit.edu	37	19	52496411	52496411	+	Missense_Mutation	SNP	T	T	C			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr19:52496411T>C	uc002pye.1	-	6	2210	c.1918A>G	c.(1918-1920)ATA>GTA	p.I640V	ZNF615_uc002pyf.1_Missense_Mutation_p.I651V|ZNF615_uc002pyg.1_Missense_Mutation_p.I532V|ZNF615_uc002pyh.1_Missense_Mutation_p.I651V|ZNF615_uc010epi.1_Missense_Mutation_p.I647V|ZNF615_uc010ydg.1_Missense_Mutation_p.I645V	NM_198480	NP_940882	Q8N8J6	ZN615_HUMAN	zinc finger protein 615	640	C2H2-type 16.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(4)|skin(1)	5		all_neural(266;0.117)		GBM - Glioblastoma multiforme(134;0.00142)|OV - Ovarian serous cystadenocarcinoma(262;0.019)		TGATGTTGTATGAGGCATGTC	0.378		NaN											0	0	0	0.024245	0	16	308									
NCR1	9437	broad.mit.edu	37	19	55420628	55420628	+	Missense_Mutation	SNP	C	C	T	rs142626797		TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr19:55420628C>T	uc002qib.2	+	4	418	c.380C>T	c.(379-381)TCG>TTG	p.S127L	NCR1_uc002qic.2_Missense_Mutation_p.S127L|NCR1_uc002qie.2_Missense_Mutation_p.S127L|NCR1_uc002qid.2_Missense_Mutation_p.S32L|NCR1_uc002qif.2_Missense_Mutation_p.S32L|NCR1_uc010esj.2_Missense_Mutation_p.S20L	NM_004829	NP_004820	O76036	NCTR1_HUMAN	natural cytotoxicity triggering receptor 1	127	Extracellular (Potential).				cellular defense response|natural killer cell activation|regulation of natural killer cell mediated cytotoxicity	integral to plasma membrane|SWI/SNF complex	receptor activity|receptor signaling protein activity			large_intestine(1)|ovary(1)	2				GBM - Glioblastoma multiforme(193;0.0449)		CCCACCCTCTCGGTTCATCCT	0.468		NaN											0	0	0	0.021553	0	5	88									
UGP2	7360	broad.mit.edu	37	2	64114722	64114722	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr2:64114722G>A	uc002scm.2	+	8	1564	c.1258G>A	c.(1258-1260)GAA>AAA	p.E420K	UGP2_uc002scl.2_Missense_Mutation_p.E409K|UGP2_uc010ypx.1_Missense_Mutation_p.E429K	NM_006759	NP_006750	Q16851	UGPA_HUMAN	UDP-glucose pyrophosphorylase 2 isoform a	420					glycogen biosynthetic process|phosphorylation|UDP-glucose metabolic process|UDP-glucuronate biosynthetic process|xenobiotic metabolic process	cytosol	metal ion binding|protein binding|UTP:glucose-1-phosphate uridylyltransferase activity				0						GACAATGAGTGAAAAGCGGGA	0.403		NaN											0	0	0	0.010729	0	12	195									
VPS54	51542	broad.mit.edu	37	2	64208891	64208891	+	Silent	SNP	G	G	A			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr2:64208891G>A	uc002scq.2	-	3	430	c.267C>T	c.(265-267)TTC>TTT	p.F89F	VPS54_uc002scp.2_Silent_p.F77F	NM_016516	NP_057600	Q9P1Q0	VPS54_HUMAN	vacuolar protein sorting 54 isoform 1	89					protein transport|retrograde transport, endosome to Golgi						0						TTTTTGTGAAGAAGTCAGATT	0.388		NaN											0	0	0	0.012319	0	22	269									
CCDC142	84865	broad.mit.edu	37	2	74709847	74709847	+	Missense_Mutation	SNP	G	G	A	rs143866681	byFrequency	TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr2:74709847G>A	uc002slr.2	-	1	511	c.118C>T	c.(118-120)CGC>TGC	p.R40C	TTC31_uc002sls.2_5'Flank|TTC31_uc010yrv.1_5'Flank|TTC31_uc002slt.2_5'Flank|TTC31_uc002slu.2_5'Flank|CCDC142_uc002slo.2_RNA|CCDC142_uc002slq.2_Missense_Mutation_p.R40C|CCDC142_uc002slp.2_Missense_Mutation_p.R40C	NM_032779	NP_116168	Q17RM4	CC142_HUMAN	coiled-coil domain containing 142	40										central_nervous_system(1)	1						ACCTCCCAGCGAAGACCGCCC	0.682		NaN											0	0	0	0.004482	0	8	62									
C2orf51	200523	broad.mit.edu	37	2	88828645	88828645	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr2:88828645G>C	uc002stb.1	+	4	338	c.196G>C	c.(196-198)GAT>CAT	p.D66H		NM_152670	NP_689883	Q96LM6	TSC21_HUMAN	chromosome 2 open reading frame 51	66						nucleus				skin(1)	1						CAAGCTAACAGATGGGTACCC	0.532		NaN											0	0	0	0.004482	0	8	84									
BUB1	699	broad.mit.edu	37	2	111427076	111427076	+	Nonsense_Mutation	SNP	G	G	C			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr2:111427076G>C	uc002tgc.2	-	6	633	c.521C>G	c.(520-522)TCA>TGA	p.S174*	BUB1_uc010yxh.1_Nonsense_Mutation_p.S154*|BUB1_uc010fkb.2_Nonsense_Mutation_p.S174*|BUB1_uc002tgd.2_Nonsense_Mutation_p.S174*	NM_004336	NP_004327	O43683	BUB1_HUMAN	budding uninhibited by benzimidazoles 1	174	BUB1 N-terminal.				apoptosis|cell division|chromosome segregation|interspecies interaction between organisms|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|regulation of sister chromatid cohesion	condensed chromosome kinetochore|cytosol	ATP binding|protein binding|protein serine/threonine kinase activity			lung(2)|breast(2)|stomach(1)|ovary(1)|kidney(1)	7		Ovarian(717;0.0822)		BRCA - Breast invasive adenocarcinoma(221;0.0556)		ATTTGATTTTGATGTTATCAT	0.358		NaN											0	0	0	0.009096	0	4	116									
SCTR	6344	broad.mit.edu	37	2	120197742	120197742	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr2:120197742G>A	uc002tma.2	-	13	1500	c.1274C>T	c.(1273-1275)GCC>GTC	p.A425V	SCTR_uc002tlz.2_Missense_Mutation_p.A247V	NM_002980	NP_002971	P47872	SCTR_HUMAN	secretin receptor precursor	425	Cytoplasmic (Potential).				digestion|excretion	integral to plasma membrane	secretin receptor activity			ovary(1)|central_nervous_system(1)|skin(1)	3					Secretin(DB00021)	CAAGTGGCTGGCCTTGGTGCT	0.627		NaN											0	0	0	0.014758	0	5	24									
ARHGEF4	50649	broad.mit.edu	37	2	131799455	131799455	+	Missense_Mutation	SNP	A	A	C			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr2:131799455A>C	uc002tsa.1	+	10	1925	c.1405A>C	c.(1405-1407)AAG>CAG	p.K469Q	ARHGEF4_uc010fmw.1_Intron|ARHGEF4_uc002tsb.1_Missense_Mutation_p.K469Q|ARHGEF4_uc010fmx.1_Missense_Mutation_p.K409Q|ARHGEF4_uc002tsc.1_Missense_Mutation_p.K12Q	NM_015320	NP_056135	Q9NR80	ARHG4_HUMAN	Rho guanine nucleotide exchange factor 4 isoform	469					apoptosis|filopodium assembly|induction of apoptosis by extracellular signals|lamellipodium assembly|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|ruffle membrane	protein domain specific binding|Rac guanyl-nucleotide exchange factor activity			breast(3)|ovary(2)|skin(1)	6		Prostate(154;0.055)		BRCA - Breast invasive adenocarcinoma(221;0.097)		CAACGAGCGGAAGCGGAGACT	0.562		NaN											0	0	0	0.004672	0	3	58									
YSK4	80122	broad.mit.edu	37	2	135739074	135739074	+	Silent	SNP	G	G	A			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr2:135739074G>A	uc002tue.1	-	9	3268	c.3237C>T	c.(3235-3237)CTC>CTT	p.L1079L	YSK4_uc002tuf.1_Silent_p.L261L|YSK4_uc010fnc.1_Intron|YSK4_uc010fnd.1_Silent_p.L966L|YSK4_uc010zbg.1_Silent_p.L211L|YSK4_uc002tuh.3_Silent_p.L807L|YSK4_uc002tui.3_Missense_Mutation_p.S1147L	NM_025052	NP_079328	Q56UN5	YSK4_HUMAN	Yeast Sps1/Ste20-related kinase 4 isoform 1	1079	Protein kinase.						ATP binding|protein serine/threonine kinase activity			stomach(2)|urinary_tract(1)|ovary(1)|breast(1)	5				BRCA - Breast invasive adenocarcinoma(221;0.112)		CTTGACTAGTGAGACCACAGT	0.368		NaN											0	0	0	0.001984	0	7	199									
LRP1B	53353	broad.mit.edu	37	2	141641540	141641540	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr2:141641540C>T	uc002tvj.1	-	25	4987	c.4015G>A	c.(4015-4017)GGC>AGC	p.G1339S	LRP1B_uc010fnl.1_Missense_Mutation_p.G521S	NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	1339	Extracellular (Potential).|LDL-receptor class B 9.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		ACTGTCAGGCCTTCTGGAGTA	0.468		NaN								TSP Lung(27;0.18)			0	0	0	0.024245	0	16	131									
SLC4A10	57282	broad.mit.edu	37	2	162751249	162751249	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr2:162751249G>C	uc002ubx.3	+	11	1439	c.1255G>C	c.(1255-1257)GAG>CAG	p.E419Q	SLC4A10_uc010fpa.1_Missense_Mutation_p.E431Q|SLC4A10_uc010zcr.1_RNA|SLC4A10_uc002uby.3_Missense_Mutation_p.E389Q|SLC4A10_uc010zcs.1_Missense_Mutation_p.E400Q	NM_022058	NP_071341	Q6U841	S4A10_HUMAN	solute carrier family 4, sodium bicarbonate	419	Cytoplasmic (Potential).				bicarbonate transport|chloride transport|sodium ion transport	integral to membrane|plasma membrane	inorganic anion exchanger activity|symporter activity			ovary(2)|lung(2)|pancreas(1)	5						AGGAATTGATGAGTTTCTGGA	0.343		NaN											0	0	0	0.006214	0	8	94									
FASTKD1	79675	broad.mit.edu	37	2	170416964	170416964	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr2:170416964G>A	uc002uev.3	-	5	1292	c.904C>T	c.(904-906)CAT>TAT	p.H302Y	FASTKD1_uc002uew.3_RNA|FASTKD1_uc002uex.3_Missense_Mutation_p.H288Y|FASTKD1_uc002uey.2_Missense_Mutation_p.H265Y	NM_024622	NP_078898	Q53R41	FAKD1_HUMAN	FAST kinase domains 1	302					apoptosis|cellular respiration	mitochondrion	ATP binding|protein kinase activity			ovary(4)	4						CTAGCAGGATGATTACACAGA	0.299		NaN											0	0	0	0.008871	0	18	239									
FASTKD1	79675	broad.mit.edu	37	2	170417266	170417266	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr2:170417266G>T	uc002uev.3	-	5	990	c.602C>A	c.(601-603)TCT>TAT	p.S201Y	FASTKD1_uc002uew.3_RNA|FASTKD1_uc002uex.3_Missense_Mutation_p.S187Y|FASTKD1_uc002uey.2_Missense_Mutation_p.S164Y	NM_024622	NP_078898	Q53R41	FAKD1_HUMAN	FAST kinase domains 1	201					apoptosis|cellular respiration	mitochondrion	ATP binding|protein kinase activity			ovary(4)	4						TATTAAAGAAGATATGTTGAC	0.294		NaN											1	0	0.000602214	0.014758	0.000654298	4	48									
METTL8	79828	broad.mit.edu	37	2	172195788	172195788	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr2:172195788G>A	uc010zdo.1	-	4	653	c.512C>T	c.(511-513)TCT>TTT	p.S171F	METTL8_uc002ugu.3_Missense_Mutation_p.S171F|METTL8_uc002ugv.3_Missense_Mutation_p.S171F|METTL8_uc002ugt.3_Missense_Mutation_p.S171F|METTL8_uc002ugs.3_Missense_Mutation_p.S121F|METTL8_uc010zdp.1_Missense_Mutation_p.S126F	NM_024770	NP_079046	B3KW44	B3KW44_HUMAN	methyltransferase like 8	171							methyltransferase activity			ovary(1)	1						GGAAAAATCAGATTCTGTTTT	0.383		NaN											0	0	0	0.020292	0	14	269									
MAP2	4133	broad.mit.edu	37	2	210560016	210560016	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr2:210560016C>T	uc002vde.1	+	7	3370	c.3122C>T	c.(3121-3123)GCT>GTT	p.A1041V	MAP2_uc002vdc.1_Missense_Mutation_p.A1041V|MAP2_uc002vdd.1_Intron|MAP2_uc002vdf.1_Intron|MAP2_uc002vdg.1_Intron|MAP2_uc002vdh.1_Intron|MAP2_uc002vdi.1_Missense_Mutation_p.A1037V	NM_002374	NP_002365	P11137	MAP2_HUMAN	microtubule-associated protein 2 isoform 1	1041					central nervous system neuron development|dendrite morphogenesis|negative regulation of microtubule depolymerization	cytoplasm|microtubule|microtubule associated complex	beta-dystroglycan binding|calmodulin binding|structural molecule activity			ovary(9)|upper_aerodigestive_tract(2)|large_intestine(2)|pancreas(2)|central_nervous_system(1)|skin(1)	17		Hepatocellular(293;0.137)|Lung NSC(271;0.163)|Renal(323;0.202)		UCEC - Uterine corpus endometrioid carcinoma (47;6.64e-05)|Epithelial(149;3.12e-100)|all cancers(144;6.88e-91)|Lung(261;0.0624)|LUSC - Lung squamous cell carcinoma(261;0.0662)|STAD - Stomach adenocarcinoma(1183;0.18)	Estramustine(DB01196)	CTGGATTTTGCTGTCCAGGGT	0.443		NaN											0	0	0	0.014758	0	5	101									
SPHKAP	80309	broad.mit.edu	37	2	228883236	228883236	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr2:228883236G>T	uc002vpq.2	-	7	2381	c.2334C>A	c.(2332-2334)CAC>CAA	p.H778Q	SPHKAP_uc002vpp.2_Missense_Mutation_p.H778Q|SPHKAP_uc010zlx.1_Missense_Mutation_p.H778Q	NM_001142644	NP_001136116	Q2M3C7	SPKAP_HUMAN	sphingosine kinase type 1-interacting protein	778						cytoplasm	protein binding			skin(5)|ovary(4)|lung(1)	10		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;8.17e-11)|all cancers(144;7.92e-08)|Lung(261;0.0168)|LUSC - Lung squamous cell carcinoma(224;0.0232)		GACTCGTGTTGTGTGAATTGC	0.512		NaN											1	0	1.80694e-10	0.009535	2.04043e-10	30	451									
NTSR1	4923	broad.mit.edu	37	20	61391508	61391508	+	Silent	SNP	C	C	G			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr20:61391508C>G	uc002ydf.2	+	4	1517	c.1146C>G	c.(1144-1146)CTC>CTG	p.L382L		NM_002531	NP_002522	P30989	NTR1_HUMAN	neurotensin receptor 1	382	Cytoplasmic (Potential).					endoplasmic reticulum|Golgi apparatus|integral to plasma membrane	neurotensin receptor activity, G-protein coupled			skin(2)|lung(1)|central_nervous_system(1)	4	Breast(26;3.65e-08)		BRCA - Breast invasive adenocarcinoma(19;3.63e-06)			TGGCCTGCCTCTGCCCGGTGT	0.627		NaN											0	0	0	0.00308	0	3	57									
SUN2	25777	broad.mit.edu	37	22	39141785	39141785	+	Silent	SNP	C	C	T			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr22:39141785C>T	uc003awh.1	-	9	1001	c.717G>A	c.(715-717)CAG>CAA	p.Q239Q	SUN2_uc011anz.1_Silent_p.Q274Q|SUN2_uc011aoa.1_Silent_p.Q228Q|SUN2_uc003awi.1_Silent_p.Q239Q|SUN2_uc010gxq.1_Silent_p.Q260Q|SUN2_uc010gxr.1_Silent_p.Q239Q|SUN2_uc010gxs.1_Silent_p.Q239Q	NM_015374	NP_056189	Q9UH99	SUN2_HUMAN	unc-84 homolog B	239	Perinuclear space.				centrosome localization|cytoskeletal anchoring at nuclear membrane|mitotic spindle organization|nuclear envelope organization|nuclear matrix anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	endosome membrane|integral to membrane|nuclear inner membrane|SUN-KASH complex	lamin binding|microtubule binding			large_intestine(1)|skin(1)	2						GGTGGAATGTCTGCAGCCCAT	0.617		NaN											0	0	0	0.009096	0	4	38									
CCDC134	79879	broad.mit.edu	37	22	42209814	42209814	+	Silent	SNP	C	C	T			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr22:42209814C>T	uc003bbh.1	+	6	661	c.552C>T	c.(550-552)ATC>ATT	p.I184I	WBP2NL_uc011ape.1_Intron|LOC339674_uc003bba.1_Intron|CCDC134_uc011apg.1_Intron	NM_024821	NP_079097	Q9H6E4	CC134_HUMAN	coiled-coil domain containing 134 precursor	184						extracellular region				ovary(2)	2						CATTTAAAATCGACCGCACAG	0.567		NaN											0	0	0	0.014758	0	4	86									
XYLB	9942	broad.mit.edu	37	3	38404477	38404477	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr3:38404477C>T	uc003cic.2	+	4	369	c.260C>T	c.(259-261)TCT>TTT	p.S87F	XYLB_uc011ayp.1_Intron|XYLB_uc003cid.1_Missense_Mutation_p.S9F	NM_005108	NP_005099	O75191	XYLB_HUMAN	xylulokinase	87					D-xylose metabolic process|generation of precursor metabolites and energy|xylulose catabolic process		ATP binding|xylulokinase activity			ovary(1)	1				KIRC - Kidney renal clear cell carcinoma(284;0.00372)|Kidney(284;0.00405)		TTCGACTTCTCTCAAGTCCTA	0.522		NaN											0	0	0	0.014758	0	4	119									
ZNF502	91392	broad.mit.edu	37	3	44763393	44763393	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr3:44763393C>G	uc011baa.1	+	4	1339	c.1084C>G	c.(1084-1086)CAG>GAG	p.Q362E	ZNF502_uc003cns.2_Missense_Mutation_p.Q362E|ZNF502_uc011bab.1_Missense_Mutation_p.Q362E|ZNF502_uc003cnt.2_Missense_Mutation_p.Q362E	NM_001134440	NP_001127912	Q8TBZ5	ZN502_HUMAN	zinc finger protein 502	362	C2H2-type 8.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				BRCA - Breast invasive adenocarcinoma(193;0.00855)|KIRC - Kidney renal clear cell carcinoma(197;0.0471)|Kidney(197;0.0589)		AGCCTTTTGTCAGAGCCCATC	0.408		NaN											0	0	0	0.001984	0	7	72									
PRSS45	377047	broad.mit.edu	37	3	46783844	46783844	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr3:46783844G>A	uc010hjl.2	-	4	683	c.683C>T	c.(682-684)TCC>TTC	p.S228F	PRSS45_uc011bam.1_RNA	NM_199183	NP_954652	Q7RTY3	PRS45_HUMAN	testis serine protease 5	260					proteolysis		serine-type endopeptidase activity				0						GGGAGGTCAGGAGCCCATCTG	0.552		NaN											0	0	0	0.00308	0	7	168									
PVRL3	25945	broad.mit.edu	37	3	110845149	110845149	+	Nonsense_Mutation	SNP	C	C	T			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr3:110845149C>T	uc003dxt.1	+	5	1036	c.1036C>T	c.(1036-1038)CAA>TAA	p.Q346*	PVRL3_uc003dxu.1_Nonsense_Mutation_p.Q323*	NM_015480	NP_056295	Q9NQS3	PVRL3_HUMAN	poliovirus receptor-related 3 precursor	346	Extracellular (Potential).|Ig-like C2-type 2.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane	cell adhesion molecule binding|protein homodimerization activity			upper_aerodigestive_tract(2)	2						TTCCCTTGGTCAAAGAAGTGA	0.313		NaN											0	0	0	0.021553	0	5	62									
MUC13	56667	broad.mit.edu	37	3	124646827	124646827	+	Silent	SNP	T	T	C			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr3:124646827T>C	uc003ehq.1	-	2	87	c.63A>G	c.(61-63)CAA>CAG	p.Q21Q		NM_033049	NP_149038	Q9H3R2	MUC13_HUMAN	mucin 13, epithelial transmembrane	21	Extracellular (Potential).					extracellular region|integral to membrane|plasma membrane					0						CTGAGTTGCCTTGGTTGGTGG	0.418		NaN											0	0	0	0.004672	0	3	140									
SLC41A3	54946	broad.mit.edu	37	3	125726027	125726027	+	Silent	SNP	C	C	T			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr3:125726027C>T	uc003eij.2	-	11	1522	c.1296G>A	c.(1294-1296)CTG>CTA	p.L432L	SLC41A3_uc003eii.2_Silent_p.L406L|SLC41A3_uc003eil.2_Silent_p.L432L|SLC41A3_uc003eik.2_Silent_p.L396L|SLC41A3_uc011bkh.1_Silent_p.L315L	NM_001008485	NP_001008485	Q96GZ6	S41A3_HUMAN	solute carrier family 41, member 3 isoform 1	432						integral to membrane|plasma membrane	cation transmembrane transporter activity				0				GBM - Glioblastoma multiforme(114;0.167)		GGTGCCAAGTCAGCCGAACCA	0.547		NaN											0	0	0	0.014758	0	4	46									
DNAJC13	23317	broad.mit.edu	37	3	132166277	132166277	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr3:132166277C>T	uc003eor.2	+	4	322	c.257C>T	c.(256-258)TCT>TTT	p.S86F	DNAJC13_uc010htq.1_Missense_Mutation_p.S86F	NM_015268	NP_056083	O75165	DJC13_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 13	86							heat shock protein binding			ovary(1)|breast(1)	2						TTAAAATTTTCTACAGAGCAC	0.353		NaN											0	0	0	0.021553	0	5	83									
CHST2	9435	broad.mit.edu	37	3	142840871	142840871	+	Missense_Mutation	SNP	A	A	G			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr3:142840871A>G	uc003evm.2	+	2	2102	c.1213A>G	c.(1213-1215)ACG>GCG	p.T405A		NM_004267	NP_004258	Q9Y4C5	CHST2_HUMAN	carbohydrate (N-acetylglucosamine-6-O)	405	Lumenal (Potential).				inflammatory response|multicellular organismal development|N-acetylglucosamine metabolic process|sulfur compound metabolic process	integral to membrane|intrinsic to Golgi membrane|trans-Golgi network	N-acetylglucosamine 6-O-sulfotransferase activity			ovary(3)	3						TATGGCTAAGACGCTGCAGAC	0.652		NaN											0	0	0	0.009096	0	4	63									
LAMP3	27074	broad.mit.edu	37	3	182853541	182853541	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr3:182853541G>C	uc003flh.3	-	5	1305	c.1081C>G	c.(1081-1083)CAA>GAA	p.Q361E		NM_014398	NP_055213	Q9UQV4	LAMP3_HUMAN	lysosomal-associated membrane protein 3	361	Lumenal (Potential).				cell proliferation	integral to membrane|lysosomal membrane				ovary(2)|central_nervous_system(1)	3	all_cancers(143;9.14e-14)|Ovarian(172;0.0355)		all cancers(12;2.91e-44)|Epithelial(37;5.52e-38)|LUSC - Lung squamous cell carcinoma(7;7.12e-25)|Lung(8;6.39e-23)|OV - Ovarian serous cystadenocarcinoma(80;4.16e-21)			TCAAAGGCTTGAAGTTGGACA	0.478		NaN											0	0	0	0.021523	0	26	297									
HRG	3273	broad.mit.edu	37	3	186383944	186383944	+	Nonsense_Mutation	SNP	C	C	T	rs146244921	by1000genomes	TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr3:186383944C>T	uc003fqq.2	+	1	147	c.124C>T	c.(124-126)CGA>TGA	p.R42*		NM_000412	NP_000403	P04196	HRG_HUMAN	histidine-rich glycoprotein precursor	42	Cystatin 1.|Interaction with ATP5A1.				fibrinolysis|platelet activation|platelet degranulation	extracellular region|plasma membrane|platelet alpha granule lumen	cysteine-type endopeptidase inhibitor activity|heparin binding			ovary(1)|central_nervous_system(1)	2	all_cancers(143;6.64e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;5.73e-20)	GBM - Glioblastoma multiforme(93;0.0683)		CAATAAAAGGCGACGGGATGG	0.512		NaN											0	0	0	0.004482	0	9	82									
TNK2	10188	broad.mit.edu	37	3	195593873	195593873	+	Silent	SNP	G	G	A			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr3:195593873G>A	uc003fvu.1	-	14	3540	c.2997C>T	c.(2995-2997)TTC>TTT	p.F999F	TNK2_uc003fvq.1_Silent_p.F408F|TNK2_uc003fvr.1_Silent_p.F526F|TNK2_uc003fvs.1_Silent_p.F1001F|TNK2_uc003fvt.1_Silent_p.F1047F	NM_005781	NP_005772	Q07912	ACK1_HUMAN	tyrosine kinase, non-receptor, 2 isoform 1	999				Missing (in Ref. 4; AAH08884).	positive regulation of peptidyl-tyrosine phosphorylation|protein ubiquitination|small GTPase mediated signal transduction	adherens junction|cytoplasmic vesicle membrane|endosome|nucleus	ATP binding|GTPase inhibitor activity|metal ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding			ovary(3)|central_nervous_system(3)|lung(2)|stomach(1)|skin(1)	10	all_cancers(143;6.48e-09)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;1.46e-22)|OV - Ovarian serous cystadenocarcinoma(49;8.3e-19)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;0.000757)	Adenosine triphosphate(DB00171)	GACCCAGCCCGAAGAGCTGCT	0.697		NaN											0	0	0	0.009096	0	3	21									
IQCG	84223	broad.mit.edu	37	3	197665561	197665561	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr3:197665561C>T	uc003fyo.2	-	4	519	c.373G>A	c.(373-375)GAG>AAG	p.E125K	IQCG_uc003fyn.2_Missense_Mutation_p.E27K|IQCG_uc003fyp.2_Missense_Mutation_p.E125K|IQCG_uc003fyq.3_Missense_Mutation_p.E125K	NM_001134435	NP_001127907	Q9H095	IQCG_HUMAN	IQ motif containing G	125											0	all_cancers(143;1.15e-09)|Ovarian(172;0.0418)|Breast(254;0.0976)		Epithelial(36;7.19e-24)|all cancers(36;3.34e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|LUSC - Lung squamous cell carcinoma(58;6.94e-07)|Lung(62;9.92e-07)	GBM - Glioblastoma multiforme(93;0.149)		GGTCCTTCCTCAGTTATTAAC	0.413		NaN											0	0	0	0.019004	0	33	497									
DGKQ	1609	broad.mit.edu	37	4	954890	954890	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr4:954890C>T	uc003gbw.2	-	22	2748	c.2674G>A	c.(2674-2676)GAG>AAG	p.E892K	DGKQ_uc010ibn.2_Missense_Mutation_p.E879K	NM_001347	NP_001338	P52824	DGKQ_HUMAN	diacylglycerol kinase, theta	892					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|platelet activation|protein kinase C signaling cascade|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to ATP|thrombin receptor signaling pathway	cytoskeleton|cytosol|nuclear speck|plasma membrane	activating transcription factor binding|ATP binding|diacylglycerol kinase activity|kinase binding|metal ion binding|phospholipase binding			kidney(1)	1			OV - Ovarian serous cystadenocarcinoma(23;0.0158)			ACCCAGGGCTCCCCGTCCACC	0.692		NaN											0	0	0	0.009096	0	4	28									
TBC1D1	23216	broad.mit.edu	37	4	37903928	37903928	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr4:37903928C>T	uc003gtb.2	+	2	555	c.212C>T	c.(211-213)TCT>TTT	p.S71F	TBC1D1_uc011byd.1_Missense_Mutation_p.S71F|TBC1D1_uc010ifd.2_Missense_Mutation_p.S71F	NM_015173	NP_055988	Q86TI0	TBCD1_HUMAN	TBC1 (tre-2/USP6, BUB2, cdc16) domain family,	71						nucleus	Rab GTPase activator activity			ovary(1)	1						GTTTCACCCTCTGGACTGAGA	0.547		NaN											0	0	0	0.001984	0	6	168									
LRRC66	339977	broad.mit.edu	37	4	52860928	52860928	+	Missense_Mutation	SNP	C	C	T	rs76998469		TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr4:52860928C>T	uc003gzi.2	-	4	2273	c.2260G>A	c.(2260-2262)GAG>AAG	p.E754K		NM_001024611	NP_001019782	Q68CR7	LRC66_HUMAN	leucine rich repeat containing 66	754						integral to membrane				ovary(1)|central_nervous_system(1)|skin(1)	3						ACATTTTCCTCAAGACTGTCT	0.483		NaN											0	0	0	0.00308	0	7	120									
KDR	3791	broad.mit.edu	37	4	55961744	55961744	+	Silent	SNP	C	C	T			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr4:55961744C>T	uc003has.2	-	20	3119	c.2817G>A	c.(2815-2817)AAG>AAA	p.K939K	KDR_uc003hat.1_Silent_p.K939K	NM_002253	NP_002244	P35968	VGFR2_HUMAN	kinase insert domain receptor precursor	939	Protein kinase.|Cytoplasmic (Potential).				angiogenesis|cell differentiation|interspecies interaction between organisms|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of focal adhesion assembly|positive regulation of positive chemotaxis|regulation of cell shape	integral to plasma membrane	ATP binding|growth factor binding|Hsp90 protein binding|integrin binding|receptor signaling protein tyrosine kinase activity|vascular endothelial growth factor receptor activity			lung(16)|soft_tissue(4)|central_nervous_system(4)|large_intestine(2)|stomach(2)|skin(2)|ovary(2)|kidney(1)	33	all_cancers(7;0.0255)|all_lung(4;0.00175)|Lung NSC(11;0.00384)|all_epithelial(27;0.034)|Glioma(25;0.08)|all_neural(26;0.101)		Epithelial(7;0.189)		Sorafenib(DB00398)|Sunitinib(DB01268)	GATGACATACCTTGTAGGGGA	0.413		NaN	Mis		NSCLC|angiosarcoma				Familial_Infantile_Hemangioma	TSP Lung(20;0.16)			0	0	0	0.004482	0	8	99									
FRAS1	80144	broad.mit.edu	37	4	79294005	79294005	+	Silent	SNP	C	C	G			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr4:79294005C>G	uc003hlb.2	+	24	3443	c.3003C>G	c.(3001-3003)CTC>CTG	p.L1001L	FRAS1_uc003hkw.2_Silent_p.L1001L	NM_025074	NP_079350	Q86XX4	FRAS1_HUMAN	Fraser syndrome 1	1001	FU 13.|Extracellular (Potential).				cell communication	integral to membrane|plasma membrane	metal ion binding			large_intestine(5)	5						ACTCGGGCCTCTGCAAGAGTA	0.537		NaN											0	0	0	0.006214	0	8	86									
SMARCAD1	56916	broad.mit.edu	37	4	95129666	95129666	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr4:95129666G>A	uc003htc.3	+	2	376	c.121G>A	c.(121-123)GAA>AAA	p.E41K	SMARCAD1_uc003htb.3_Missense_Mutation_p.E41K|SMARCAD1_uc003htd.3_Missense_Mutation_p.E41K|SMARCAD1_uc010ila.2_5'UTR	NM_020159	NP_064544	Q9H4L7	SMRCD_HUMAN	SWI/SNF-related, matrix-associated	41					chromatin modification|nucleotide metabolic process|positive regulation of transcription, DNA-dependent|protein homooligomerization|regulation of DNA recombination	nuclear matrix	ATP binding|DNA binding|helicase activity			skin(2)|ovary(1)|breast(1)	4				OV - Ovarian serous cystadenocarcinoma(123;4.33e-08)		TCTTAGTGCTGAAGAGGAGAA	0.438		NaN											0	0	0	0.006214	0	7	127									
KIAA1109	84162	broad.mit.edu	37	4	123166210	123166210	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr4:123166210G>A	uc003ieh.2	+	30	4997	c.4952G>A	c.(4951-4953)CGA>CAA	p.R1651Q	KIAA1109_uc003iek.2_Missense_Mutation_p.R270Q	NM_015312	NP_056127	Q2LD37	K1109_HUMAN	fragile site-associated protein	1651					regulation of cell growth|regulation of epithelial cell differentiation	integral to membrane|nucleus				ovary(8)|skin(2)|pancreas(1)|central_nervous_system(1)	12						GCTAGTACCCGACATCCAGCT	0.343		NaN											0	0	0	0.00308	0	8	192									
ARHGAP10	79658	broad.mit.edu	37	4	148743974	148743974	+	Splice_Site	SNP	G	G	A			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr4:148743974G>A	uc003ilf.2	+	2	250	c.250_splice	c.e2+1	p.D84_splice	ARHGAP10_uc003ile.1_Splice_Site_p.D84_splice	NM_024605	NP_078881	A1A4S6	RHG10_HUMAN	Rho GTPase activating protein 10						apoptosis|filopodium assembly|regulation of apoptosis|small GTPase mediated signal transduction	cytosol|perinuclear region of cytoplasm|plasma membrane	cytoskeletal adaptor activity|SH3 domain binding			skin(2)|pancreas(1)|lung(1)	4	all_hematologic(180;0.151)	Renal(17;0.0166)		GBM - Glioblastoma multiforme(119;0.0423)		CGATGCATAGGTAATTAAACA	0.393		NaN											0	0	0	0.009096	0	4	152									
DCLK2	166614	broad.mit.edu	37	4	151023764	151023764	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr4:151023764G>A	uc003ilm.3	+	2	656	c.556G>A	c.(556-558)GAA>AAA	p.E186K	DCLK2_uc003iln.3_Missense_Mutation_p.E186K|DCLK2_uc003ilo.3_Missense_Mutation_p.E186K|DCLK2_uc003ilp.3_RNA	NM_001040260	NP_001035350	Q8N568	DCLK2_HUMAN	doublecortin-like kinase 2 isoform a	186					intracellular signal transduction	cytoplasm|cytoskeleton	ATP binding|protein serine/threonine kinase activity			ovary(3)	3	all_hematologic(180;0.151)					TGTGAAAAGTGAAGTAAAAGA	0.428		NaN											0	0	0	0.008291	0	10	53									
F2R	2149	broad.mit.edu	37	5	76028929	76028929	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr5:76028929C>G	uc003ken.3	+	2	1144	c.879C>G	c.(877-879)ATC>ATG	p.I293M		NM_001992	NP_001983	P25116	PAR1_HUMAN	coagulation factor II receptor precursor	293	Cytoplasmic (Potential).				activation of caspase activity|anatomical structure morphogenesis|connective tissue replacement involved in inflammatory response wound healing|negative regulation of cell proliferation|platelet activation|positive regulation of blood coagulation|positive regulation of cell migration|positive regulation of collagen biosynthetic process|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of JAK-STAT cascade|positive regulation of MAPKKK cascade|positive regulation of release of sequestered calcium ion into cytosol|positive regulation of transcription, DNA-dependent|STAT protein import into nucleus|tyrosine phosphorylation of STAT protein	caveola|extracellular region|Golgi apparatus|integral to plasma membrane|platelet dense tubular network	receptor binding|thrombin receptor activity	p.I293I(1)		ovary(3)	3		all_lung(232;0.000414)|Lung NSC(167;0.0011)|Prostate(461;0.00955)|Ovarian(174;0.0129)		all cancers(79;4.43e-43)	Streptokinase(DB00086)	ATGTGTCTATCATTCGATGTC	0.483		NaN											0	0	0	0.00308	0	8	137									
FAT2	2196	broad.mit.edu	37	5	150920280	150920280	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr5:150920280C>G	uc003lue.3	-	10	8900	c.8887G>C	c.(8887-8889)GAG>CAG	p.E2963Q	GM2A_uc011dcs.1_Intron	NM_001447	NP_001438	Q9NYQ8	FAT2_HUMAN	FAT tumor suppressor 2 precursor	2963	Extracellular (Potential).|Cadherin 26.				epithelial cell migration|homophilic cell adhesion	cell-cell adherens junction|integral to membrane|nucleus	calcium ion binding			ovary(4)|upper_aerodigestive_tract(1)|skin(1)	6		Medulloblastoma(196;0.0912)|all_hematologic(541;0.104)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			ATCCTCCACTCATCTCCAACT	0.527		NaN											0	0	0	0.009096	0	4	69									
BNIP1	662	broad.mit.edu	37	5	172571562	172571562	+	Missense_Mutation	SNP	A	A	C			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr5:172571562A>C	uc003mcj.3	+	1	118	c.14A>C	c.(13-15)CAA>CCA	p.Q5P	BNIP1_uc003mci.3_Missense_Mutation_p.Q5P|BNIP1_uc003mck.3_Missense_Mutation_p.Q5P|BNIP1_uc003mcl.3_Missense_Mutation_p.Q5P	NM_001205	NP_001196	Q12981	SEC20_HUMAN	BCL2/adenovirus E1B 19kD interacting protein 1	5	Cytoplasmic (Potential).				anti-apoptosis|apoptosis|endoplasmic reticulum membrane fusion|endoplasmic reticulum organization|induction of apoptosis|vesicle-mediated transport	integral to endoplasmic reticulum membrane|nuclear envelope|SNARE complex	protein binding			ovary(1)	1	Renal(175;0.000159)|Lung NSC(126;0.00199)|all_lung(126;0.00351)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000183)			GCGGCTCCCCAAGACGTCCAC	0.607		NaN									OREG0017054	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.010729	0	4	12									
ZKSCAN3	80317	broad.mit.edu	37	6	28333833	28333833	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr6:28333833G>A	uc003nle.3	+	6	1604	c.1388G>A	c.(1387-1389)TGG>TAG	p.W463*	ZKSCAN3_uc010jrc.2_Nonsense_Mutation_p.W463*|ZKSCAN3_uc003nlf.3_Nonsense_Mutation_p.W315*|uc010jrd.2_5'Flank	NM_024493	NP_077819	Q9BRR0	ZKSC3_HUMAN	zinc finger with KRAB and SCAN domains 3	463				QGEAWKSRMESQLENVETPMS -> TGRGWKVGWKASWKML KLPCP (in Ref. 5; AAB16813).	positive regulation of transcription, DNA-dependent|viral reproduction	nucleus	chromatin binding|DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(2)	2						GGAGAGGCCTGGAAAAGTAGG	0.433		NaN											0	0	0	0.021553	0	5	60									
MDC1	9656	broad.mit.edu	37	6	30670531	30670531	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr6:30670531C>T	uc003nrg.3	-	13	6429	c.5989G>A	c.(5989-5991)GAG>AAG	p.E1997K	MDC1_uc003nrf.3_Missense_Mutation_p.E628K	NM_014641	NP_055456	Q14676	MDC1_HUMAN	mediator of DNA-damage checkpoint 1	1997	Required for nuclear localization (NLS2).|BRCT 2.				cell cycle|double-strand break repair via homologous recombination|intra-S DNA damage checkpoint	focal adhesion|nucleoplasm	FHA domain binding|protein C-terminus binding			breast(2)|ovary(1)|kidney(1)	4						CCTCTCACCTCTAGCAGCCTT	0.512		NaN						Other_conserved_DNA_damage_response_genes					0	0	0	0.020292	0	13	196									
C6orf27	80737	broad.mit.edu	37	6	31734536	31734536	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr6:31734536G>C	uc011dog.1	-	14	2126	c.1888C>G	c.(1888-1890)CAG>GAG	p.Q630E	C6orf27_uc003nxd.2_Missense_Mutation_p.Q305E	NM_025258	NP_079534	Q9Y334	G7C_HUMAN	G7c protein precursor	630						extracellular region				ovary(3)	3						AGCTGGGTCTGAAGACCTGGG	0.493		NaN											0	0	0	0.009096	0	4	52									
C6orf27	80737	broad.mit.edu	37	6	31735227	31735227	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr6:31735227G>C	uc011dog.1	-	12	1939	c.1701C>G	c.(1699-1701)TTC>TTG	p.F567L	C6orf27_uc003nxd.2_Missense_Mutation_p.F242L	NM_025258	NP_079534	Q9Y334	G7C_HUMAN	G7c protein precursor	567						extracellular region				ovary(3)	3						TCACCATCCAGAACTGCCCAA	0.602		NaN											0	0	0	0.004482	0	6	108									
TCP11	6954	broad.mit.edu	37	6	35088708	35088708	+	Silent	SNP	C	C	T			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr6:35088708C>T	uc003okd.2	-	6	913	c.732G>A	c.(730-732)CAG>CAA	p.Q244Q	TCP11_uc003ojz.1_Silent_p.Q169Q|TCP11_uc003oka.2_Silent_p.Q169Q|TCP11_uc003okb.2_Silent_p.Q168Q|TCP11_uc003okc.2_Silent_p.Q168Q|TCP11_uc011dsu.1_Silent_p.Q226Q|TCP11_uc011dsv.1_Silent_p.Q193Q|TCP11_uc011dsw.1_Silent_p.Q198Q	NM_001093728	NP_001087197	Q8WWU5	TCP11_HUMAN	t-complex 11 isoform 1	231					cell differentiation|multicellular organismal development|spermatogenesis	integral to membrane				ovary(3)|skin(2)	5						TGAGGAGTTCCTGGAATTTAG	0.443		NaN											0	0	0	0.01441	0	45	534									
ABCC10	89845	broad.mit.edu	37	6	43400436	43400436	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr6:43400436G>A	uc003ouy.1	+	3	933	c.718G>A	c.(718-720)GAG>AAG	p.E240K	ABCC10_uc003ouz.1_Missense_Mutation_p.E197K	NM_033450	NP_258261	Q5T3U5	MRP7_HUMAN	ATP-binding cassette, sub-family C, member 10	240						integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(6)|central_nervous_system(1)	7	all_lung(25;0.00536)		Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0152)|OV - Ovarian serous cystadenocarcinoma(102;0.0804)			GGCCTGTGGAGAGCTCCGGCA	0.637		NaN											0	0	0	0.021553	0	5	56									
SLC17A5	26503	broad.mit.edu	37	6	74345112	74345112	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr6:74345112C>G	uc003phn.3	-	6	940	c.812G>C	c.(811-813)AGA>ACA	p.R271T	SLC17A5_uc010kax.2_5'UTR|SLC17A5_uc010kay.2_RNA|SLC17A5_uc011dyo.1_Missense_Mutation_p.R140T	NM_012434	NP_036566	Q9NRA2	S17A5_HUMAN	sialin	271			Missing (in ISSD).		anion transport	integral to plasma membrane|lysosomal membrane|membrane fraction	sialic acid:hydrogen symporter activity			skin(5)|central_nervous_system(1)	6						TACCTGATTTCTTAATGATGA	0.274		NaN											0	0	0	0.013537	0	12	94									
DOPEY1	23033	broad.mit.edu	37	6	83845382	83845382	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr6:83845382C>T	uc003pjs.1	+	20	3175	c.2915C>T	c.(2914-2916)TCT>TTT	p.S972F	DOPEY1_uc011dyy.1_Missense_Mutation_p.S963F|DOPEY1_uc010kbl.1_Missense_Mutation_p.S963F|DOPEY1_uc003pjt.2_5'Flank	NM_015018	NP_055833	Q5JWR5	DOP1_HUMAN	dopey family member 1	972					protein transport					ovary(2)|breast(1)|central_nervous_system(1)	4		all_cancers(76;2.29e-06)|Acute lymphoblastic leukemia(125;3.41e-06)|all_hematologic(105;0.000865)|all_epithelial(107;0.00203)		BRCA - Breast invasive adenocarcinoma(397;0.053)		CTCGATGGTTCTACTAGCTCT	0.393		NaN											0	0	0	0.020292	0	14	182									
EZR	7430	broad.mit.edu	37	6	159191809	159191809	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr6:159191809C>G	uc003qrt.3	-	9	1292	c.1077G>C	c.(1075-1077)AAG>AAC	p.K359N	EZR_uc011efr.1_5'Flank|EZR_uc011efs.1_Missense_Mutation_p.K327N|EZR_uc003qru.3_Missense_Mutation_p.K359N	NM_003379	NP_003370	P15311	EZRI_HUMAN	ezrin	359	Interaction with SCYL3.				actin filament bundle assembly|axon guidance|cytoskeletal anchoring at plasma membrane|leukocyte cell-cell adhesion|membrane to membrane docking|regulation of cell shape	actin filament|apical plasma membrane|basolateral plasma membrane|cortical cytoskeleton|cytosol|extrinsic to membrane|filopodium|microvillus membrane|nucleolus|ruffle membrane	actin filament binding|cell adhesion molecule binding			ovary(1)	1		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;2.16e-17)|BRCA - Breast invasive adenocarcinoma(81;6.58e-06)		TCTCTGCCTTCTTTGTCTTCT	0.567		NaN											0	0	0	0.008291	0	10	149									
FOXK1	221937	broad.mit.edu	37	7	4794948	4794948	+	Silent	SNP	G	G	C			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr7:4794948G>C	uc003snc.1	+	4	994	c.984G>C	c.(982-984)CTG>CTC	p.L328L	FOXK1_uc003sna.1_Silent_p.L165L|FOXK1_uc003snb.1_3'UTR	NM_001037165	NP_001032242	P85037	FOXK1_HUMAN	forkhead box K1	328	Fork-head.				cell differentiation|embryo development|muscle organ development|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|magnesium ion binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			upper_aerodigestive_tract(1)|skin(1)	2		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.101)|OV - Ovarian serous cystadenocarcinoma(56;7.43e-15)		AGCTGACCCTGAGCGGGATCT	0.642		NaN											0	0	0	0.001984	0	6	54									
MLXIPL	51085	broad.mit.edu	37	7	73010266	73010266	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr7:73010266C>G	uc003tyn.1	-	14	2140	c.2092G>C	c.(2092-2094)GAG>CAG	p.E698Q	MLXIPL_uc003tyj.1_Missense_Mutation_p.E77Q|MLXIPL_uc003tyk.1_Intron|MLXIPL_uc003tyl.1_Missense_Mutation_p.E696Q|MLXIPL_uc003tym.1_Intron|MLXIPL_uc003tyo.1_RNA|MLXIPL_uc003typ.1_Missense_Mutation_p.E604Q	NM_032951	NP_116569	Q9NP71	WBS14_HUMAN	Williams Beuren syndrome chromosome region 14	698	Helix-loop-helix motif.				anatomical structure morphogenesis|energy reserve metabolic process|glucose mediated signaling pathway|intracellular protein kinase cascade|negative regulation of cell cycle arrest|negative regulation of oxidative phosphorylation|negative regulation of peptidyl-serine phosphorylation|positive regulation of cell proliferation|positive regulation of fatty acid biosynthetic process|positive regulation of glycolysis|positive regulation of transcription from RNA polymerase II promoter|triglyceride homeostasis	cytosol|transcription factor complex	carbohydrate response element binding|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity|transcription factor binding			pancreas(1)	1		Lung NSC(55;0.0659)|all_lung(88;0.152)				AGGATGTACTCAGCTGTCTTC	0.607		NaN											0	0	0	0.014758	0	4	26									
KIAA1324L	222223	broad.mit.edu	37	7	86556202	86556202	+	Missense_Mutation	SNP	T	T	G			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr7:86556202T>G	uc011kha.1	-	9	1305	c.1120A>C	c.(1120-1122)AAA>CAA	p.K374Q	KIAA1324L_uc003uif.1_Missense_Mutation_p.K134Q|KIAA1324L_uc011kgz.1_Missense_Mutation_p.K260Q|KIAA1324L_uc003uie.2_Missense_Mutation_p.K207Q	NM_001142749	NP_001136221	A8MWY0	K132L_HUMAN	hypothetical protein LOC222223 isoform 1	374	Extracellular (Potential).					integral to membrane				ovary(6)|skin(1)	7	Esophageal squamous(14;0.0058)					CGGCAGATTTTGGGCTCTATC	0.378		NaN											0	0	0	0.014758	0	5	190									
DBF4	10926	broad.mit.edu	37	7	87516657	87516657	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr7:87516657C>T	uc003ujf.1	+	5	968	c.464C>T	c.(463-465)TCA>TTA	p.S155L	DBF4_uc003ujh.1_5'UTR|DBF4_uc003ujg.1_5'UTR|DBF4_uc011khf.1_5'UTR	NM_006716	NP_006707	Q9UBU7	DBF4A_HUMAN	activator of S phase kinase	155	BRCT 2.				cell cycle checkpoint|DNA replication|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle	nucleoplasm	enzyme activator activity|nucleic acid binding|protein binding|zinc ion binding			lung(2)	2	Esophageal squamous(14;0.00202)	Breast(660;0.0334)				TTTATTCCTTCAAATAGTATA	0.229		NaN											0	0	0	0.009096	0	4	36									
SAMD9	54809	broad.mit.edu	37	7	92734318	92734318	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr7:92734318C>G	uc003umf.2	-	3	1349	c.1093G>C	c.(1093-1095)GAT>CAT	p.D365H	SAMD9_uc003umg.2_Missense_Mutation_p.D365H	NM_017654	NP_060124	Q5K651	SAMD9_HUMAN	sterile alpha motif domain containing 9	365						cytoplasm				ovary(3)|skin(2)|breast(1)|central_nervous_system(1)	7	all_cancers(62;5.71e-11)|all_epithelial(64;3.25e-10)|Breast(17;0.000675)|Lung NSC(181;0.0969)|all_lung(186;0.125)		STAD - Stomach adenocarcinoma(171;0.000302)			GTTTTAAAATCTGCTTTAAAT	0.333		NaN											0	0	0	0.008291	0	9	188									
EPHB4	2050	broad.mit.edu	37	7	100410820	100410820	+	Silent	SNP	G	G	A			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr7:100410820G>A	uc003uwn.1	-	11	2258	c.1767C>T	c.(1765-1767)GTC>GTT	p.V589V	EPHB4_uc003uwm.1_Silent_p.V496V|EPHB4_uc010lhj.1_Silent_p.V589V	NM_004444	NP_004435	P54760	EPHB4_HUMAN	EPH receptor B4 precursor	589	Cytoplasmic (Potential).				cell proliferation|organ morphogenesis|regulation of angiogenesis	cell surface|integral to plasma membrane	ATP binding|ephrin receptor activity			lung(4)|stomach(3)|skin(3)|central_nervous_system(2)|ovary(2)|breast(1)	15	Lung NSC(181;0.041)|all_lung(186;0.0581)					GGTCGATGTAGACCTTAGTAC	0.507		NaN											0	0	0	0.009096	0	4	88									
C7orf60	154743	broad.mit.edu	37	7	112472660	112472660	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr7:112472660C>G	uc003vgo.1	-	4	671	c.544G>C	c.(544-546)GAA>CAA	p.E182Q	C7orf60_uc011kms.1_Missense_Mutation_p.E208Q	NM_152556	NP_689769	Q1RMZ1	CG060_HUMAN	hypothetical protein LOC154743	182										ovary(2)|skin(1)	3						AGAAATTCTTCAAACTTCAGA	0.308		NaN											0	0	0	0.001984	0	6	133									
NOS3	4846	broad.mit.edu	37	7	150698385	150698385	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr7:150698385G>C	uc003wif.2	+	11	1596	c.1300G>C	c.(1300-1302)GAG>CAG	p.E434Q	NOS3_uc011kuy.1_Missense_Mutation_p.E228Q|NOS3_uc011kuz.1_Missense_Mutation_p.E434Q|NOS3_uc011kva.1_Missense_Mutation_p.E434Q|NOS3_uc011kvb.1_Missense_Mutation_p.E434Q	NM_000603	NP_000594	P29474	NOS3_HUMAN	nitric oxide synthase 3 isoform 1	434	Interaction with NOSIP.				anti-apoptosis|arginine catabolic process|blood vessel remodeling|endothelial cell migration|mitochondrion organization|negative regulation of muscle hyperplasia|negative regulation of platelet activation|nitric oxide biosynthetic process|platelet activation|positive regulation of angiogenesis|positive regulation of guanylate cyclase activity|positive regulation of vasodilation|regulation of blood vessel size|regulation of nitric-oxide synthase activity|regulation of systemic arterial blood pressure by endothelin|response to fluid shear stress|response to heat|smooth muscle hyperplasia	caveola|cytoskeleton|cytosol|Golgi membrane	actin monomer binding|arginine binding|cadmium ion binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|tetrahydrobiopterin binding			central_nervous_system(5)|large_intestine(2)|skin(1)	8	all_neural(206;0.219)		OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)	L-Arginine(DB00125)|L-Citrulline(DB00155)|Rosuvastatin(DB01098)|Tetrahydrobiopterin(DB00360)	CCTGGAGAATGAGCAGAAGGC	0.612		NaN											0	0	0	0.00308	0	5	83									
INSIG1	3638	broad.mit.edu	37	7	155094081	155094081	+	Silent	SNP	C	C	T			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr7:155094081C>T	uc003wly.2	+	4	869	c.658C>T	c.(658-660)CTA>TTA	p.L220L	INSIG1_uc011kvu.1_Silent_p.L68L|INSIG1_uc003wlz.2_Intron	NM_005542	NP_005533	O15503	INSI1_HUMAN	insulin induced gene 1 isoform 1	220	Helical; (Potential).				cell proliferation|ER-nuclear sterol response pathway	endoplasmic reticulum membrane|integral to membrane	protein binding				0	all_neural(206;0.119)	all_hematologic(28;0.0592)	OV - Ovarian serous cystadenocarcinoma(82;0.011)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		CATAGCTTTTCTAGCTACGCT	0.438		NaN											0	0	0	0.006214	0	9	107									
EXTL3	2137	broad.mit.edu	37	8	28575593	28575593	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr8:28575593G>A	uc003xgz.1	+	3	2610	c.2017G>A	c.(2017-2019)GAG>AAG	p.E673K		NM_001440	NP_001431	O43909	EXTL3_HUMAN	exostoses-like 3	673	Lumenal (Potential).					integral to membrane|intrinsic to endoplasmic reticulum membrane	glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity|metal ion binding|protein binding			skin(2)	2		Ovarian(32;0.069)		KIRC - Kidney renal clear cell carcinoma(542;0.107)|Kidney(114;0.129)|Colorectal(74;0.228)		TTATGAGCGGGAGGAAGTGCT	0.542		NaN											0	0	0	0.001984	0	7	97									
TEX15	56154	broad.mit.edu	37	8	30702398	30702398	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr8:30702398C>G	uc003xil.2	-	1	4136	c.4136G>C	c.(4135-4137)AGA>ACA	p.R1379T		NM_031271	NP_112561	Q9BXT5	TEX15_HUMAN	testis expressed 15	1379										ovary(3)|upper_aerodigestive_tract(2)|skin(2)	7				KIRC - Kidney renal clear cell carcinoma(542;0.0918)|Kidney(114;0.111)		CTCTTTTTCTCTACAGCTCTG	0.398		NaN											0	0	0	0.001984	0	6	174									
WHSC1L1	54904	broad.mit.edu	37	8	38173473	38173473	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr8:38173473C>G	uc003xli.2	-	10	2461	c.1943G>C	c.(1942-1944)AGA>ACA	p.R648T	WHSC1L1_uc011lbm.1_Missense_Mutation_p.R648T|WHSC1L1_uc010lwe.2_Missense_Mutation_p.R648T	NM_023034	NP_075447	Q9BZ95	NSD3_HUMAN	WHSC1L1 protein isoform long	648					cell differentiation|cell growth|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome	histone-lysine N-methyltransferase activity|zinc ion binding			breast(1)	1	Colorectal(12;0.000442)|Esophageal squamous(3;0.0725)	all_lung(54;0.00787)|Lung NSC(58;0.0295)|Hepatocellular(245;0.065)	Epithelial(3;3.12e-43)|all cancers(3;1.72e-38)|BRCA - Breast invasive adenocarcinoma(5;2.84e-27)|LUSC - Lung squamous cell carcinoma(2;2.79e-25)|Lung(2;5.03e-23)|COAD - Colon adenocarcinoma(9;0.0511)			AGATGTGTCTCTGTATGCTGA	0.433		NaN	T	NUP98	AML								0	0	0	0.021553	0	6	166									
RIMS2	9699	broad.mit.edu	37	8	104898276	104898276	+	Silent	SNP	C	C	G			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr8:104898276C>G	uc003yls.2	+	2	1024	c.783C>G	c.(781-783)CTC>CTG	p.L261L	RIMS2_uc003ylp.2_Silent_p.L483L|RIMS2_uc003ylw.2_Silent_p.L291L|RIMS2_uc003ylq.2_Silent_p.L291L|RIMS2_uc003ylr.2_Silent_p.L291L	NM_014677	NP_055492	Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	514					intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			ovary(6)|lung(2)|breast(2)|skin(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	15			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			ATGATTCTCTCAGTTCAGACC	0.438		NaN								HNSCC(12;0.0054)			0	0	0	0.00308	0	8	67									
CDC14B	8555	broad.mit.edu	37	9	99301371	99301371	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr9:99301371C>T	uc004awj.2	-	7	1068	c.616G>A	c.(616-618)GAA>AAA	p.E206K	CDC14B_uc004awk.2_Missense_Mutation_p.E206K|CDC14B_uc004awl.2_RNA|CDC14B_uc004awi.2_Missense_Mutation_p.E169K	NM_033331	NP_201588	O60729	CC14B_HUMAN	CDC14 homolog B isoform 2	206	Linker.				activation of anaphase-promoting complex activity|DNA repair|G2/M transition DNA damage checkpoint	nucleolus|nucleoplasm	protein binding|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(1)	1		Acute lymphoblastic leukemia(62;0.0559)				TCATAGTGTTCATATTCATCA	0.279		NaN											0	0	0	0.001984	0	7	91									
RXRA	6256	broad.mit.edu	37	9	137328351	137328351	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr9:137328351C>T	uc004cfb.2	+	10	1442	c.1280C>T	c.(1279-1281)TCC>TTC	p.S427F	RXRA_uc004cfc.1_Missense_Mutation_p.S330F	NM_002957	NP_002948	P19793	RXRA_HUMAN	retinoid X receptor, alpha	427	Ligand-binding.				cellular lipid metabolic process|cholesterol metabolic process|interspecies interaction between organisms|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to retinoic acid|vitamin metabolic process	nuclear chromatin|nucleoplasm	enzyme binding|ligand-regulated transcription factor activity|protein heterodimerization activity|retinoic acid-responsive element binding|retinoid-X receptor activity|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|transcription coactivator activity|vitamin D receptor binding|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)	2				OV - Ovarian serous cystadenocarcinoma(145;4.66e-08)|Epithelial(140;6.72e-08)|all cancers(34;2.22e-07)	Acitretin(DB00459)|Adapalene(DB00210)|Alitretinoin(DB00523)|Etretinate(DB00926)	GCTCTGCGCTCCATCGGGCTC	0.607		NaN											0	0	0	0.021553	0	5	86									
TPRN	286262	broad.mit.edu	37	9	140086816	140086816	+	Silent	SNP	G	G	T			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr9:140086816G>T	uc004clt.2	-	3	1785	c.1785C>A	c.(1783-1785)GGC>GGA	p.G595G	TPRN_uc004clu.2_Silent_p.G595G	NM_173691	NP_775962	Q4KMQ1	TPRN_HUMAN	hypothetical protein LOC286262 isoform 2	656					sensory perception of sound	stereocilium					0						AGCTGGACAGGCCTGTGAATG	0.672		NaN											1	0	1.23904e-05	0.014758	1.36839e-05	5	23									
SLC25A6	293	broad.mit.edu	37	X	1508489	1508489	+	Silent	SNP	G	G	A			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chrX:1508489G>A	uc004cpt.2	-	2	339	c.243C>T	c.(241-243)TAC>TAT	p.Y81Y	SLC25A6_uc004cpu.2_RNA	NM_001636	NP_001627	P12236	ADT3_HUMAN	adenine nucleotide translocator 3	81	Solcar 1.|Helical; Name=2; (By similarity).				active induction of host immune response by virus|apoptosis|energy reserve metabolic process|regulation of insulin secretion|viral infectious cycle	integral to membrane|mitochondrial inner membrane presequence translocase complex	ATP:ADP antiporter activity|protein binding				0		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)			Clodronate(DB00720)	GAGTGGGGAAGTAGCGAATGA	0.567		NaN											0	0	0	0.010729	0	11	189									
DDX53	168400	broad.mit.edu	37	X	23019978	23019978	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chrX:23019978G>A	uc004daj.2	+	1	1892	c.1804G>A	c.(1804-1806)GAG>AAG	p.E602K		NM_182699	NP_874358	Q86TM3	DDX53_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 53	602						nucleus	ATP binding|ATP-dependent helicase activity|RNA binding			large_intestine(1)|ovary(1)|kidney(1)	3						AGTAATGGCTGAGCAATACAA	0.383		NaN											0	0	0	0.009096	0	4	120									
FAM47A	158724	broad.mit.edu	37	X	34149795	34149795	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chrX:34149795G>A	uc004ddg.2	-	1	634	c.601C>T	c.(601-603)CCA>TCA	p.P201S		NM_203408	NP_981953	Q5JRC9	FA47A_HUMAN	hypothetical protein LOC158724	201	Pro-rich.									ovary(4)|central_nervous_system(1)	5						GGAGGCTCTGGGAGGAGATGG	0.617		NaN											0	0	0	0.004672	0	3	64									
ZNF630	57232	broad.mit.edu	37	X	47918817	47918817	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chrX:47918817C>G	uc004div.3	-	5	1266	c.1014G>C	c.(1012-1014)CAG>CAC	p.Q338H	ZNF630_uc010nhz.1_Intron|ZNF630_uc004diw.2_Missense_Mutation_p.Q214H	NM_001037735	NP_001032824	Q2M218	ZN630_HUMAN	zinc finger protein 630	338	C2H2-type 3; degenerate.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|lung(1)	2						TATGGACTCTCTGATGAACAG	0.428		NaN											0	0	0	0.00308	0	8	123									
WDR13	64743	broad.mit.edu	37	X	48460204	48460204	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chrX:48460204G>A	uc004dkh.1	+	7	1011	c.864G>A	c.(862-864)ATG>ATA	p.M288I	WDR13_uc010nif.1_Missense_Mutation_p.M166I|WDR13_uc004dki.1_Missense_Mutation_p.M196I|WDR13_uc004dkj.1_Missense_Mutation_p.M288I|WDR13_uc004dkk.1_Missense_Mutation_p.M196I|WDR13_uc004dkl.3_Missense_Mutation_p.M196I	NM_017883	NP_060353	Q9H1Z4	WDR13_HUMAN	WD repeat domain 13 protein	288						cytoplasm|nucleus				ovary(2)	2						TGCATGTCATGAACATCTCCA	0.602		NaN											0	0	0	0.009096	0	3	32									
USP51	158880	broad.mit.edu	37	X	55514287	55514287	+	Silent	SNP	C	C	G			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chrX:55514287C>G	uc004dun.1	-	2	1165	c.1086G>C	c.(1084-1086)CTG>CTC	p.L362L	USP51_uc011moo.1_Silent_p.L66L	NM_201286	NP_958443	Q70EK9	UBP51_HUMAN	ubiquitin specific protease 51	362					ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity|zinc ion binding			ovary(1)|lung(1)|breast(1)	3						TTAGCCCTCTCAGGCCTACAG	0.403		NaN											0	0	0	0.020292	0	15	223									
ATRX	546	broad.mit.edu	37	X	76939952	76939952	+	Missense_Mutation	SNP	A	A	T			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chrX:76939952A>T	uc004ecp.3	-	9	1028	c.796T>A	c.(796-798)TAC>AAC	p.Y266N	ATRX_uc004ecq.3_Missense_Mutation_p.Y228N|ATRX_uc004eco.3_Missense_Mutation_p.Y51N|ATRX_uc004ecr.2_Missense_Mutation_p.Y227N|ATRX_uc010nlx.1_Missense_Mutation_p.Y266N|ATRX_uc010nly.1_Missense_Mutation_p.Y211N	NM_000489	NP_000480	P46100	ATRX_HUMAN	transcriptional regulator ATRX isoform 1	266	ADD.|PHD-type; atypical.				DNA methylation|DNA recombination|DNA repair|regulation of transcription, DNA-dependent	nuclear heterochromatin	ATP binding|chromo shadow domain binding|DNA binding|DNA helicase activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(14)|pancreas(12)|lung(1)|breast(1)|skin(1)|kidney(1)	30					Phosphatidylserine(DB00144)	TGACAAATGTAGCAATACCAT	0.388		NaN	Mis|F|N		Pancreatic neuroendocrine tumors		ATR-X (alpha thalassemia/mental retardation) syndrome						0	0	0	0.001984	0	7	448									
STAG2	10735	broad.mit.edu	37	X	123179197	123179197	+	Nonsense_Mutation	SNP	C	C	T			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chrX:123179197C>T	uc004etz.3	+	7	985	c.646C>T	c.(646-648)CGA>TGA	p.R216*	STAG2_uc004eua.2_Nonsense_Mutation_p.R216*|STAG2_uc004eub.2_Nonsense_Mutation_p.R216*|STAG2_uc004euc.2_Nonsense_Mutation_p.R216*|STAG2_uc004eud.2_Nonsense_Mutation_p.R216*|STAG2_uc004eue.2_Nonsense_Mutation_p.R216*	NM_006603	NP_006594	Q8N3U4	STAG2_HUMAN	stromal antigen 2 isoform b	216					cell division|meiosis|mitotic metaphase/anaphase transition|mitotic prometaphase|negative regulation of DNA endoreduplication|sister chromatid cohesion	chromatin|chromosome, centromeric region|nucleoplasm	protein binding			ovary(4)|skin(1)	5						CAGAGCATTTCGACATACAAG	0.343		NaN											0	0	0	0.010504	0	20	335									
F8	2157	broad.mit.edu	37	X	154197729	154197729	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chrX:154197729G>A	uc004fmt.2	-	7	1057	c.886C>T	c.(886-888)CTT>TTT	p.L296F		NM_000132	NP_000123	P00451	FA8_HUMAN	coagulation factor VIII isoform a precursor	296	Plastocyanin-like 2.|F5/8 type A 1.				acute-phase response|blood coagulation, intrinsic pathway|cell adhesion|platelet activation|platelet degranulation	extracellular space|plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity|protein binding			ovary(5)|large_intestine(2)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	11	all_cancers(53;7.19e-17)|all_epithelial(53;9.83e-11)|all_lung(58;6.63e-07)|Lung NSC(58;2.08e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)				Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Drotrecogin alfa(DB00055)	TTCCTCACAAGAAATGTGTGA	0.463		NaN											0	0	0	0.028581	0	12	195									
KDM6A	7403	broad.mit.edu	37	X	44938507	44938507	+	Frame_Shift_Del	DEL	A	A	-			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08			A	-	A	A		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chrX:44938507delA	uc004dge.3	+	20	3430	c.3055delA	c.(3055-3057)AAAfs	p.K1019fs	KDM6A_uc010nhk.2_Frame_Shift_Del_p.K985fs|KDM6A_uc011mkz.1_Frame_Shift_Del_p.K1071fs|KDM6A_uc011mla.1_Frame_Shift_Del_p.K974fs|KDM6A_uc011mlb.1_Frame_Shift_Del_p.K1026fs|KDM6A_uc011mlc.1_Frame_Shift_Del_p.K723fs|KDM6A_uc011mld.1_Frame_Shift_Del_p.K658fs	NM_021140	NP_066963	O15550	KDM6A_HUMAN	ubiquitously transcribed tetratricopeptide	1019					histone H3-K4 methylation		metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			kidney(24)|haematopoietic_and_lymphoid_tissue(23)|oesophagus(11)|large_intestine(7)|lung(5)|breast(4)|central_nervous_system(3)|urinary_tract(3)|endometrium(2)|pancreas(2)	84						TGGAACAAAGAAAATCTGGCA	0.398		NaN	D|N|F|S		renal|oesophageal SCC|MM								NaN	NaN	NaN	NaN	NaN	7	106	---	---