Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	isArtifactMode	oxoGCut	pox	pox_cutoff	qox	t_alt_count	t_ref_count	validation_alt_allele	validation_tumor_sample							
SCNN1D	6339	broad.mit.edu	37	1	1221484	1221484	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr1:1221484G>A	uc001adu.1	+	6	869	c.245G>A	c.(244-246)CGC>CAC	p.R82H	SCNN1D_uc001adt.1_Missense_Mutation_p.R246H|SCNN1D_uc001adw.2_Missense_Mutation_p.R148H|SCNN1D_uc001adx.2_5'UTR|SCNN1D_uc001adv.2_Missense_Mutation_p.R82H	NM_002978	NP_002969			sodium channel, nonvoltage-gated 1, delta												0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;3.01e-35)|OV - Ovarian serous cystadenocarcinoma(86;2.46e-21)|Colorectal(212;0.000157)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00229)|BRCA - Breast invasive adenocarcinoma(365;0.00251)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.034)|Lung(427;0.199)		CGCGGGAACCGCCTCAAGACG	0.692		NaN											0	0	0	0.009096	0	4	25									
CHD5	26038	broad.mit.edu	37	1	6214906	6214906	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr1:6214906C>T	uc001amb.1	-	5	659	c.559G>A	c.(559-561)GTC>ATC	p.V187I		NM_015557	NP_056372	Q8TDI0	CHD5_HUMAN	chromodomain helicase DNA binding protein 5	187					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|DNA binding|zinc ion binding			central_nervous_system(3)|breast(3)|ovary(2)|upper_aerodigestive_tract(1)|lung(1)|skin(1)|pancreas(1)	12	Ovarian(185;0.0634)	all_cancers(23;5.36e-32)|all_epithelial(116;2.32e-17)|all_neural(13;3.68e-06)|all_lung(118;3.94e-06)|all_hematologic(16;2.39e-05)|Lung NSC(185;5.33e-05)|Acute lymphoblastic leukemia(12;0.000372)|Glioma(11;0.00127)|Renal(390;0.00188)|Colorectal(325;0.00342)|Breast(487;0.00373)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.15)		Epithelial(90;3.08e-37)|GBM - Glioblastoma multiforme(13;1.36e-31)|OV - Ovarian serous cystadenocarcinoma(86;7.7e-19)|Colorectal(212;9.97e-08)|COAD - Colon adenocarcinoma(227;1.07e-05)|Kidney(185;6.16e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.00109)|BRCA - Breast invasive adenocarcinoma(365;0.0012)|STAD - Stomach adenocarcinoma(132;0.00346)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.193)		GCACCCAGGACGGTCATCATT	0.498		NaN											0	0	0	0.01441	0	61	44									
PADI2	11240	broad.mit.edu	37	1	17395694	17395694	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr1:17395694C>T	uc001baf.2	-	16	1925	c.1843G>A	c.(1843-1845)GAG>AAG	p.E615K	PADI2_uc010ocm.1_Missense_Mutation_p.E499K	NM_007365	NP_031391	Q9Y2J8	PADI2_HUMAN	peptidyl arginine deiminase, type II	615					peptidyl-citrulline biosynthetic process from peptidyl-arginine	cytoplasm	calcium ion binding|protein-arginine deiminase activity			ovary(3)|pancreas(1)|central_nervous_system(1)|skin(1)	6		Colorectal(325;3.46e-05)|Breast(348;0.000162)|Lung NSC(340;0.000422)|Renal(390;0.000518)|all_lung(284;0.000546)|Ovarian(437;0.00671)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00583)|BRCA - Breast invasive adenocarcinoma(304;1.49e-05)|COAD - Colon adenocarcinoma(227;1.54e-05)|Kidney(64;0.000258)|KIRC - Kidney renal clear cell carcinoma(64;0.00348)|STAD - Stomach adenocarcinoma(196;0.0072)|READ - Rectum adenocarcinoma(331;0.0698)|Lung(427;0.201)	L-Citrulline(DB00155)	ACGTGCATCTCCAGGCAGCAT	0.592		NaN											0	0	0	0.010729	0	7	98									
PADI4	23569	broad.mit.edu	37	1	17682587	17682587	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr1:17682587G>A	uc001baj.2	+	12	1448	c.1420G>A	c.(1420-1422)GAG>AAG	p.E474K		NM_012387	NP_036519	Q9UM07	PADI4_HUMAN	peptidyl arginine deiminase, type IV	474					chromatin modification|peptidyl-citrulline biosynthetic process from peptidyl-arginine|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	calcium ion binding|protein-arginine deiminase activity			ovary(1)|skin(1)	2		Colorectal(325;3.46e-05)|Breast(348;0.000162)|all_lung(284;0.000338)|Lung NSC(340;0.00042)|Renal(390;0.000518)|Ovarian(437;0.00409)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00537)|BRCA - Breast invasive adenocarcinoma(304;8.54e-06)|COAD - Colon adenocarcinoma(227;1.33e-05)|Kidney(64;0.000223)|KIRC - Kidney renal clear cell carcinoma(64;0.00313)|STAD - Stomach adenocarcinoma(196;0.00707)|READ - Rectum adenocarcinoma(331;0.0689)|Lung(427;0.199)	L-Citrulline(DB00155)	CCACGTGGACGAGTTCCTGAG	0.632		NaN											0	0	0	0.004482	0	8	48									
UBR4	23352	broad.mit.edu	37	1	19423752	19423752	+	Missense_Mutation	SNP	T	T	G			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr1:19423752T>G	uc001bbi.2	-	91	13329	c.13325A>C	c.(13324-13326)TAT>TCT	p.Y4442S	UBR4_uc010ocv.1_Missense_Mutation_p.Y5S|UBR4_uc009vph.2_Missense_Mutation_p.Y76S|UBR4_uc010ocw.1_Missense_Mutation_p.Y106S|UBR4_uc001bbg.2_Missense_Mutation_p.Y153S|UBR4_uc001bbh.2_Missense_Mutation_p.Y151S	NM_020765	NP_065816	Q5T4S7	UBR4_HUMAN	retinoblastoma-associated factor 600	4442					interspecies interaction between organisms	cytoplasm|cytoskeleton|integral to membrane|nucleus	calmodulin binding|ubiquitin-protein ligase activity|zinc ion binding			kidney(10)|ovary(7)|breast(4)|pancreas(2)|skin(2)	25		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000328)|Lung NSC(340;0.000406)|Breast(348;0.000814)|Ovarian(437;0.00774)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00674)|BRCA - Breast invasive adenocarcinoma(304;5.43e-05)|Kidney(64;0.000337)|KIRC - Kidney renal clear cell carcinoma(64;0.00426)|STAD - Stomach adenocarcinoma(196;0.00715)|READ - Rectum adenocarcinoma(331;0.0816)		CCGCATACGATAAACAATCCT	0.498		NaN											0	0	0	0.001168	0	4	51									
USP48	84196	broad.mit.edu	37	1	22074693	22074693	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr1:22074693C>G	uc001bfb.2	-	7	1084	c.846G>C	c.(844-846)AAG>AAC	p.K282N	USP48_uc010odq.1_Missense_Mutation_p.K282N|USP48_uc009vqc.2_Missense_Mutation_p.K282N|USP48_uc001bfc.2_Missense_Mutation_p.K282N|USP48_uc001bfe.1_Missense_Mutation_p.K282N|USP48_uc001bff.2_Missense_Mutation_p.K282N	NM_032236	NP_115612	Q86UV5	UBP48_HUMAN	ubiquitin specific protease 48 isoform a	282					ubiquitin-dependent protein catabolic process	mitochondrion|nucleus	cysteine-type peptidase activity|ubiquitin thiolesterase activity			ovary(1)|lung(1)	2		Colorectal(325;3.46e-05)|all_lung(284;4.29e-05)|Lung NSC(340;4.66e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0182)|OV - Ovarian serous cystadenocarcinoma(117;4.74e-26)|COAD - Colon adenocarcinoma(152;1.3e-05)|GBM - Glioblastoma multiforme(114;1.86e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000614)|STAD - Stomach adenocarcinoma(196;0.00644)|KIRC - Kidney renal clear cell carcinoma(1967;0.00711)|Lung(427;0.0327)|READ - Rectum adenocarcinoma(331;0.0657)|LUSC - Lung squamous cell carcinoma(448;0.0753)		GAAGTCGAATCTTTCTTGTTG	0.348		NaN											0	0	0	0.009096	0	4	25									
ZNF436	80818	broad.mit.edu	37	1	23688971	23688971	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr1:23688971C>G	uc001bgt.2	-	3	1285	c.904G>C	c.(904-906)GGG>CGG	p.G302R	ZNF436_uc001bgu.2_Missense_Mutation_p.G302R	NM_030634	NP_085137	Q9C0F3	ZN436_HUMAN	zinc finger protein 436	302					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)	1		Colorectal(325;3.46e-05)|Lung NSC(340;4.15e-05)|all_lung(284;6.64e-05)|Renal(390;0.000219)|Breast(348;0.00262)|Ovarian(437;0.00539)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;6.44e-26)|Colorectal(126;5.5e-08)|COAD - Colon adenocarcinoma(152;3.09e-06)|GBM - Glioblastoma multiforme(114;5.97e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000977)|KIRC - Kidney renal clear cell carcinoma(1967;0.00336)|STAD - Stomach adenocarcinoma(196;0.0127)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.0853)|LUSC - Lung squamous cell carcinoma(448;0.187)		GGCCTCTCCCCTGTGTGGACT	0.522		NaN											0	0	0	0.021523	0	22	108									
ASAP3	55616	broad.mit.edu	37	1	23763473	23763473	+	Silent	SNP	G	G	C			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr1:23763473G>C	uc001bha.2	-	15	1531	c.1407C>G	c.(1405-1407)CGC>CGG	p.R469R	ASAP3_uc001bgy.1_5'Flank|ASAP3_uc001bgz.1_RNA|ASAP3_uc010odz.1_Silent_p.R338R|ASAP3_uc010oea.1_Silent_p.R460R|ASAP3_uc001bhb.2_5'UTR	NM_017707	NP_060177	Q8TDY4	ASAP3_HUMAN	ArfGAP with SH3 domain, ankyrin repeat and PH	469	Arf-GAP.				regulation of ARF GTPase activity	cytoplasm	ARF GTPase activator activity|zinc ion binding			large_intestine(1)|ovary(1)|skin(1)	3						CGCCCAGTTCGCGGTGGACGC	0.677		NaN											0	0	0	0.00308	0	6	29									
ARID1A	8289	broad.mit.edu	37	1	27107008	27107008	+	Nonsense_Mutation	SNP	C	C	T			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr1:27107008C>T	uc001bmv.1	+	20	6992	c.6619C>T	c.(6619-6621)CAG>TAG	p.Q2207*	ARID1A_uc001bmu.1_Nonsense_Mutation_p.Q1990*|ARID1A_uc001bmx.1_Nonsense_Mutation_p.Q1053*|ARID1A_uc009vsm.1_Nonsense_Mutation_p.Q535*|ARID1A_uc009vsn.1_Nonsense_Mutation_p.Q449*	NM_006015	NP_006006	O14497	ARI1A_HUMAN	AT rich interactive domain 1A isoform a	2207					androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding			ovary(124)|pancreas(5)|central_nervous_system(3)|endometrium(3)|kidney(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	142		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		TGCCGCCACACAGTTCCAGCA	0.642		NaN	Mis|N|F|S|D		clear cell ovarian carcinoma|RCC								0	0	0	0.01441	0	59	65									
TTC39A	22996	broad.mit.edu	37	1	51761767	51761767	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr1:51761767C>T	uc001csl.2	-	13	1342	c.1237G>A	c.(1237-1239)GAA>AAA	p.E413K	TTC39A_uc001csk.2_Missense_Mutation_p.E378K|TTC39A_uc010ond.1_Missense_Mutation_p.E350K|TTC39A_uc010one.1_Missense_Mutation_p.E377K|TTC39A_uc010onf.1_Missense_Mutation_p.E381K|TTC39A_uc001csn.2_Missense_Mutation_p.E412K|TTC39A_uc001csj.2_Missense_Mutation_p.E14K	NM_001080494	NP_001073963	Q5SRH9	TT39A_HUMAN	tetratricopeptide repeat domain 39A isoform 2	413							binding			skin(1)	1						AATTCCACTTCGTCGTCCCCG	0.592		NaN											0	0	0	0.016723	0	10	4									
CC2D1B	200014	broad.mit.edu	37	1	52821911	52821911	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr1:52821911C>A	uc001ctq.1	-	18	2157	c.2019G>T	c.(2017-2019)CAG>CAT	p.Q673H	CC2D1B_uc001ctr.2_Missense_Mutation_p.Q213H|CC2D1B_uc001cts.2_Missense_Mutation_p.Q358H	NM_032449	NP_115825	Q5T0F9	C2D1B_HUMAN	coiled-coil and C2 domain containing 1B	673										ovary(2)	2						GGTCGAGGCCCTGAGCCTGGG	0.572		NaN											1	0	8.10497e-08	0.010504	9.039e-08	18	71									
LRRC7	57554	broad.mit.edu	37	1	70509735	70509735	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr1:70509735G>C	uc001dep.2	+	20	3984	c.3954G>C	c.(3952-3954)CAG>CAC	p.Q1318H	LRRC7_uc009wbg.2_Missense_Mutation_p.Q602H|LRRC7_uc001deq.2_Intron	NM_020794	NP_065845	Q96NW7	LRRC7_HUMAN	leucine rich repeat containing 7	1318						centrosome|focal adhesion|nucleolus	protein binding			ovary(9)|breast(2)|central_nervous_system(2)|liver(1)	14						TAAACTTGCAGACTAAGTCTA	0.398		NaN											0	0	0	0.010729	0	12	45									
DDX20	11218	broad.mit.edu	37	1	112309338	112309338	+	Silent	SNP	G	G	A			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr1:112309338G>A	uc001ebs.2	+	11	2649	c.2292G>A	c.(2290-2292)CTG>CTA	p.L764L	DDX20_uc010owf.1_Silent_p.L526L|DDX20_uc001ebt.2_Silent_p.L372L	NM_007204	NP_009135	Q9UHI6	DDX20_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 20	764					assembly of spliceosomal tri-snRNP|ncRNA metabolic process	Cajal body|cytoskeleton|cytosol|spliceosomal complex	ATP binding|ATP-dependent RNA helicase activity|DNA binding|protein binding			lung(1)|kidney(1)	2		all_cancers(81;1.06e-05)|all_epithelial(167;7.36e-06)|all_lung(203;2.44e-05)|Lung NSC(69;4.15e-05)		Lung(183;0.0234)|Colorectal(144;0.0282)|all cancers(265;0.0614)|Epithelial(280;0.0999)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		AAATACGTCTGAGTTTTTCTG	0.453		NaN											0	0	0	0.004482	0	9	86									
SYT6	148281	broad.mit.edu	37	1	114680320	114680320	+	Silent	SNP	G	G	A			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr1:114680320G>A	uc001eev.2	-	3	863	c.613C>T	c.(613-615)CTG>TTG	p.L205L		NM_205848	NP_995320	Q5T7P8	SYT6_HUMAN	synaptotagmin VI	290	Cytoplasmic (Potential).|C2 1.				acrosomal vesicle exocytosis	cell junction|cytosol|integral to membrane|perinuclear endoplasmic reticulum|peripheral to membrane of membrane fraction|synaptic vesicle membrane	clathrin binding|metal ion binding|protein homodimerization activity|syntaxin binding|transporter activity			ovary(3)|central_nervous_system(1)|pancreas(1)	5	Lung SC(450;0.184)	all_cancers(81;4.41e-08)|all_epithelial(167;5.18e-08)|all_lung(203;1.58e-05)|Lung NSC(69;2.82e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		GTGGGGTTCAGGGTCTTGCGG	0.557		NaN											0	0	0	0.004007	0	14	71									
NBPF10	100132406	broad.mit.edu	37	1	145302714	145302714	+	Silent	SNP	A	A	G	rs9424867		TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr1:145302714A>G	uc001end.3	+	8	1187	c.1152A>G	c.(1150-1152)TTA>TTG	p.L384L	NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|NBPF10_uc001emp.3_Intron|NBPF10_uc010oyi.1_5'UTR|NBPF10_uc001emq.1_Silent_p.L113L	NM_001039703	NP_001034792	A6NDV3	A6NDV3_HUMAN	hypothetical protein LOC100132406	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment											0	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		AGGAGAAGTTACGGGAAGGGA	0.527		NaN											0	0	0	0.014758	0	5	97									
HIST2H2BE	8349	broad.mit.edu	37	1	149857978	149857978	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr1:149857978G>C	uc001etc.2	-	1	255	c.213C>G	c.(211-213)TTC>TTG	p.F71L	HIST2H2AC_uc001etd.2_5'Flank	NM_003528	NP_003519	Q16778	H2B2E_HUMAN	histone cluster 2, H2be	71					defense response to bacterium|nucleosome assembly	nucleosome|nucleus	DNA binding|protein binding			ovary(1)	1	Breast(34;0.0124)|all_hematologic(923;0.127)		STAD - Stomach adenocarcinoma(528;0.133)|LUSC - Lung squamous cell carcinoma(543;0.221)			CGATGCGCTCGAAGATGTCGT	0.622		NaN											0	0	0	0.01441	0	152	138									
DENND4B	9909	broad.mit.edu	37	1	153907309	153907309	+	Silent	SNP	C	C	T			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr1:153907309C>T	uc001fdd.1	-	18	3101	c.2700G>A	c.(2698-2700)CAG>CAA	p.Q900Q	uc001fdc.1_RNA	NM_014856	NP_055671	O75064	DEN4B_HUMAN	DENN/MADD domain containing 4B	900	Gln-rich.									ovary(1)	1	all_lung(78;2.89e-32)|Lung NSC(65;2.27e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)			gctgctgttgctgctgctgct	0.468		NaN											0	0	0	0.004482	0	7	120									
NES	10763	broad.mit.edu	37	1	156640211	156640211	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr1:156640211C>G	uc001fpq.2	-	4	3902	c.3769G>C	c.(3769-3771)GGG>CGG	p.G1257R		NM_006617	NP_006608	P48681	NEST_HUMAN	nestin	1257	Tail.				brain development|embryonic camera-type eye development|G2/M transition of mitotic cell cycle|negative regulation of apoptosis|positive regulation of intermediate filament depolymerization|positive regulation of neural precursor cell proliferation|stem cell proliferation	cytoplasm|intermediate filament	intermediate filament binding|structural molecule activity			ovary(6)	6	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					TCTACTTTCCCCAGGGCTTCA	0.642		NaN											0	0	0	0.013726	0	27	240									
FCRL5	83416	broad.mit.edu	37	1	157489551	157489551	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr1:157489551G>C	uc001fqu.2	-	13	2800	c.2642C>G	c.(2641-2643)CCT>CGT	p.P881R	FCRL5_uc009wsm.2_Missense_Mutation_p.P881R	NM_031281	NP_112571	Q96RD9	FCRL5_HUMAN	Fc receptor-like 5	881	Cytoplasmic (Potential).					integral to membrane|plasma membrane	receptor activity			ovary(3)|breast(2)|central_nervous_system(1)	6	all_hematologic(112;0.0378)|Hepatocellular(266;0.178)	Prostate(1639;0.231)				GTCAGAGGCAGGCTTTCTCCC	0.502		NaN											0	0	0	0.013537	0	8	60									
DCAF6	55827	broad.mit.edu	37	1	167973115	167973115	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr1:167973115G>C	uc001gew.2	+	9	1247	c.1005G>C	c.(1003-1005)CAG>CAC	p.Q335H	DCAF6_uc001gev.2_Missense_Mutation_p.Q335H|DCAF6_uc001gex.2_Missense_Mutation_p.Q335H|DCAF6_uc010plk.1_Missense_Mutation_p.Q304H|DCAF6_uc001gey.2_Missense_Mutation_p.Q188H	NM_001017977	NP_001017977	Q58WW2	DCAF6_HUMAN	IQ motif and WD repeats 1 isoform b	335					positive regulation of transcription from RNA polymerase II promoter	CUL4 RING ubiquitin ligase complex|nucleus	ligand-dependent nuclear receptor transcription coactivator activity			ovary(1)|central_nervous_system(1)|skin(1)	3						TAGGAGAGCAGAGTCCCAATG	0.353		NaN											0	0	0	0.009096	0	3	111									
TIPRL	261726	broad.mit.edu	37	1	168169157	168169157	+	Missense_Mutation	SNP	T	T	C			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr1:168169157T>C	uc001gfg.2	+	7	837	c.692T>C	c.(691-693)CTC>CCC	p.L231P	TIPRL_uc001gfh.2_Silent_p.P232P	NM_152902	NP_690866	O75663	TIPRL_HUMAN	TIP41, TOR signalling pathway regulator-like	231	Interaction with PPP2CA.				DNA damage checkpoint|negative regulation of protein phosphatase type 2A activity	cytoplasm	protein binding			ovary(1)	1	all_hematologic(923;0.215)					CCACCTTCCCTCTTCACGGAA	0.343		NaN											0	0	0	0.01441	0	123	34									
CACNA1E	777	broad.mit.edu	37	1	181680116	181680116	+	Missense_Mutation	SNP	T	T	A			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr1:181680116T>A	uc001gow.2	+	8	1247	c.1082T>A	c.(1081-1083)GTG>GAG	p.V361E	CACNA1E_uc009wxs.2_Missense_Mutation_p.V268E	NM_000721	NP_000712	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type,	361	Cytoplasmic (Potential).				energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(3)|central_nervous_system(2)|pancreas(1)	6						AGAGAGAGAGTGGAGAACCGA	0.522		NaN											0	0	0	0.00308	0	6	195									
FAM129A	116496	broad.mit.edu	37	1	184777366	184777366	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr1:184777366G>C	uc001gra.2	-	10	1371	c.1177C>G	c.(1177-1179)CTA>GTA	p.L393V	FAM129A_uc001grb.1_Missense_Mutation_p.L156V|FAM129A_uc009wyh.1_Missense_Mutation_p.L221V|FAM129A_uc009wyi.1_Missense_Mutation_p.L191V	NM_052966	NP_443198	Q9BZQ8	NIBAN_HUMAN	niban protein isoform 2	393					negative regulation of protein phosphorylation|positive regulation of protein phosphorylation|positive regulation of translation|response to endoplasmic reticulum stress	cytoplasm|nucleus|plasma membrane				ovary(3)|skin(1)	4						AGCCGGTCTAGATGCTGCATT	0.433		NaN											0	0	0	0.01441	0	42	18									
CTSE	1510	broad.mit.edu	37	1	206318358	206318358	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr1:206318358G>A	uc001hdu.2	+	2	234	c.116G>A	c.(115-117)CGG>CAG	p.R39Q	CTSE_uc001hdv.2_Missense_Mutation_p.R39Q|CTSE_uc010prs.1_Intron	NM_001910	NP_001901	P14091	CATE_HUMAN	cathepsin E isoform a preproprotein	39					antigen processing and presentation of exogenous peptide antigen via MHC class II|digestion|proteolysis	endosome	aspartic-type endopeptidase activity			ovary(1)	1			BRCA - Breast invasive adenocarcinoma(75;0.0754)			CTGCGGGCACGGAGCCAGCTC	0.557		NaN											0	0	0	0.020292	0	13	40									
ACTN2	88	broad.mit.edu	37	1	236907968	236907968	+	Missense_Mutation	SNP	C	C	T	rs143749154	byFrequency	TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr1:236907968C>T	uc001hyf.2	+	12	1502	c.1298C>T	c.(1297-1299)TCG>TTG	p.S433L	ACTN2_uc001hyg.2_Missense_Mutation_p.S225L|ACTN2_uc009xgi.1_Missense_Mutation_p.S433L|ACTN2_uc010pxu.1_Missense_Mutation_p.S122L|ACTN2_uc001hyh.2_Missense_Mutation_p.S121L	NM_001103	NP_001094	P35609	ACTN2_HUMAN	actinin, alpha 2	433	Spectrin 2.				focal adhesion assembly|microspike assembly|muscle filament sliding|platelet activation|platelet degranulation|protein homotetramerization|regulation of apoptosis|synaptic transmission	actin filament|cytosol|dendritic spine|extracellular region|filopodium|focal adhesion|nucleolus|platelet alpha granule lumen|pseudopodium|Z disc	actin binding|calcium ion binding|FATZ 1 binding|identical protein binding|integrin binding|protein dimerization activity|structural constituent of muscle|titin binding|titin Z domain binding|ZASP binding			ovary(4)|skin(1)	5	Ovarian(103;0.0634)|Breast(184;0.221)	all_cancers(173;0.00661)|Acute lymphoblastic leukemia(190;0.109)|Prostate(94;0.174)	OV - Ovarian serous cystadenocarcinoma(106;0.00168)			GAGTCGGCGTCGCTGACAGAG	0.602		NaN											0	0	0	0.00874	0	38	22									
DHTKD1	55526	broad.mit.edu	37	10	12148334	12148334	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr10:12148334G>T	uc001ild.3	+	11	2085	c.1986G>T	c.(1984-1986)GAG>GAT	p.E662D		NM_018706	NP_061176	Q96HY7	DHTK1_HUMAN	dehydrogenase E1 and transketolase domain	662					glycolysis	mitochondrion	oxoglutarate dehydrogenase (succinyl-transferring) activity|thiamine pyrophosphate binding			ovary(1)|central_nervous_system(1)	2		Renal(717;0.228)	BRCA - Breast invasive adenocarcinoma(52;0.188)			CCCTGTGGGAGGCACAGTTTG	0.527		NaN											1	0	0.000157383	0.00308	0.000170451	6	157									
CUBN	8029	broad.mit.edu	37	10	17083214	17083214	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr10:17083214C>T	uc001ioo.2	-	27	3887	c.3835G>A	c.(3835-3837)GAG>AAG	p.E1279K		NM_001081	NP_001072	O60494	CUBN_HUMAN	cubilin precursor	1279	CUB 8.				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			ovary(9)|breast(4)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|kidney(1)	19					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	ACCACATTCTCACATGCTGGA	0.343		NaN											0	0	0	0.020292	0	10	74									
CUBN	8029	broad.mit.edu	37	10	17107557	17107557	+	Missense_Mutation	SNP	A	A	T			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr10:17107557A>T	uc001ioo.2	-	22	3141	c.3089T>A	c.(3088-3090)CTC>CAC	p.L1030H		NM_001081	NP_001072	O60494	CUBN_HUMAN	cubilin precursor	1030	CUB 5.	Calcium 1; via carbonyl oxygen.			cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			ovary(9)|breast(4)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|kidney(1)	19					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	TTCATAAGCGAGGTCGGAGTC	0.428		NaN											0	0	0	0.015359	0	33	196									
STOX1	219736	broad.mit.edu	37	10	70645483	70645483	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr10:70645483G>A	uc001jos.2	+	3	2018	c.1931G>A	c.(1930-1932)CGA>CAA	p.R644Q	STOX1_uc001jor.2_Intron|STOX1_uc009xpy.2_Intron|STOX1_uc001joq.2_Missense_Mutation_p.R534Q	NM_001130161	NP_001123633	Q6ZVD7	STOX1_HUMAN	storkhead box 1 isoform a	644						cytoplasm|nucleolus	DNA binding			kidney(1)|skin(1)	2						CTGCCATCACGAGGTGCCTCC	0.453		NaN											0	0	0	0.00632	0	21	73									
GBF1	8729	broad.mit.edu	37	10	104129518	104129518	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr10:104129518G>C	uc001kux.1	+	25	3438	c.3198G>C	c.(3196-3198)GAG>GAC	p.E1066D	GBF1_uc001kuy.1_Missense_Mutation_p.E1066D|GBF1_uc001kuz.1_Missense_Mutation_p.E1067D	NM_004193	NP_004184	Q92538	GBF1_HUMAN	golgi-specific brefeldin A resistant guanine	1066					COPI coating of Golgi vesicle|post-Golgi vesicle-mediated transport|regulation of ARF protein signal transduction|retrograde vesicle-mediated transport, Golgi to ER	Golgi membrane	ARF guanyl-nucleotide exchange factor activity|protein binding			ovary(1)|central_nervous_system(1)	2		Colorectal(252;0.0236)		Epithelial(162;5.16e-08)|all cancers(201;1.19e-06)		AGCGGGAAGAGACACCATCAA	0.483		NaN											0	0	0	0.012319	0	16	38									
GBF1	8729	broad.mit.edu	37	10	104142018	104142018	+	Silent	SNP	C	C	T			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr10:104142018C>T	uc001kux.1	+	40	5745	c.5505C>T	c.(5503-5505)ATC>ATT	p.I1835I	GBF1_uc001kuy.1_Silent_p.I1831I|GBF1_uc001kuz.1_Silent_p.I1832I	NM_004193	NP_004184	Q92538	GBF1_HUMAN	golgi-specific brefeldin A resistant guanine	1835	Pro-rich.				COPI coating of Golgi vesicle|post-Golgi vesicle-mediated transport|regulation of ARF protein signal transduction|retrograde vesicle-mediated transport, Golgi to ER	Golgi membrane	ARF guanyl-nucleotide exchange factor activity|protein binding			ovary(1)|central_nervous_system(1)	2		Colorectal(252;0.0236)		Epithelial(162;5.16e-08)|all cancers(201;1.19e-06)		CTGCGCTCATCGAGGCCACCT	0.637		NaN											0	0	0	0.01441	0	43	160									
OSBPL5	114879	broad.mit.edu	37	11	3125474	3125474	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr11:3125474G>C	uc001lxk.2	-	10	1351	c.1193C>G	c.(1192-1194)TCC>TGC	p.S398C	OSBPL5_uc010qxq.1_Missense_Mutation_p.S309C|OSBPL5_uc009ydw.2_Missense_Mutation_p.S330C|OSBPL5_uc001lxl.2_Missense_Mutation_p.S330C|OSBPL5_uc009ydx.2_Missense_Mutation_p.S422C	NM_020896	NP_065947	Q9H0X9	OSBL5_HUMAN	oxysterol-binding protein-like protein 5 isoform	398					cholesterol metabolic process|cholesterol transport|Golgi to plasma membrane transport	cytosol	oxysterol binding|protein binding			large_intestine(2)|central_nervous_system(1)	3		all_epithelial(84;0.000236)|Medulloblastoma(188;0.00106)|Breast(177;0.00328)|Ovarian(85;0.00556)|all_neural(188;0.00681)		BRCA - Breast invasive adenocarcinoma(625;0.00607)|LUSC - Lung squamous cell carcinoma(625;0.207)		GTTCAGGAAGGAGCGCGGCTC	0.627		NaN											0	0	0	0.010504	0	17	48									
OR5I1	10798	broad.mit.edu	37	11	55702943	55702943	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr11:55702943C>G	uc010ris.1	-	1	934	c.934G>C	c.(934-936)GAT>CAT	p.D312H		NM_006637	NP_006628	Q13606	OR5I1_HUMAN	olfactory receptor, family 5, subfamily I,	312	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						CATGAAGAATCTACCTTTGAT	0.353		NaN											0	0	0	0.004672	0	3	21									
OR8K3	219473	broad.mit.edu	37	11	56085843	56085843	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr11:56085843G>A	uc010rjf.1	+	1	61	c.61G>A	c.(61-63)GCT>ACT	p.A21T		NM_001005202	NP_001005202	Q8NH51	OR8K3_HUMAN	olfactory receptor, family 8, subfamily K,	21	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|large_intestine(1)|central_nervous_system(1)	4	Esophageal squamous(21;0.00448)					CACAGATATCGCTGAGCTGCA	0.438		NaN											0	0	0	0.01441	0	42	102									
OR5B17	219965	broad.mit.edu	37	11	58125948	58125948	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr11:58125948G>T	uc010rke.1	-	1	595	c.595C>A	c.(595-597)CTT>ATT	p.L199I		NM_001005489	NP_001005489	Q8NGF7	OR5BH_HUMAN	olfactory receptor, family 5, subfamily B,	199	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3	Esophageal squamous(5;0.0027)	Breast(21;0.0778)				CTTGATATAAGAACAAGAATC	0.363		NaN											1	0	0.00909568	0.009096	0.00950768	3	37									
PITPNM1	9600	broad.mit.edu	37	11	67267792	67267792	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr11:67267792C>G	uc001olx.2	-	5	930	c.741G>C	c.(739-741)GAG>GAC	p.E247D	PITPNM1_uc001olw.2_5'Flank|PITPNM1_uc001oly.2_Missense_Mutation_p.E247D|PITPNM1_uc001olz.2_Missense_Mutation_p.E247D	NM_004910	NP_004901	O00562	PITM1_HUMAN	phosphatidylinositol transfer protein,	247					brain development|lipid metabolic process|phototransduction|protein transport	cleavage furrow|endoplasmic reticulum membrane|Golgi cisterna membrane|lipid particle|membrane fraction|midbody	metal ion binding|phosphatidylinositol transporter activity			lung(2)|central_nervous_system(1)	3						TGCGAGCAGTCTCCTCTTCCA	0.682		NaN											0	0	0	0.01441	0	57	260									
CPT1A	1374	broad.mit.edu	37	11	68525172	68525172	+	Silent	SNP	C	C	G			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr11:68525172C>G	uc001oog.3	-	19	2432	c.2262G>C	c.(2260-2262)CTG>CTC	p.L754L	CPT1A_uc001oof.3_Intron|CPT1A_uc009ysj.2_Intron	NM_001876	NP_001867	P50416	CPT1A_HUMAN	carnitine palmitoyltransferase 1A liver isoform	754	Cytoplasmic (Potential).				carnitine shuttle|fatty acid beta-oxidation	integral to membrane|mitochondrial outer membrane	carnitine O-palmitoyltransferase activity			skin(2)	2	Esophageal squamous(3;3.28e-14)		LUAD - Lung adenocarcinoma(13;0.0676)|STAD - Stomach adenocarcinoma(18;0.142)		L-Carnitine(DB00583)|Perhexiline(DB01074)	TTGCTTCTTTCAGGTGCCTTC	0.398		NaN											0	0	0	0.008291	0	9	39									
ATM	472	broad.mit.edu	37	11	108216494	108216494	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr11:108216494G>A	uc001pkb.1	+	58	8828	c.8443G>A	c.(8443-8445)GAG>AAG	p.E2815K	ATM_uc009yxr.1_Missense_Mutation_p.E2815K|C11orf65_uc010rvx.1_Intron|C11orf65_uc009yxu.1_Intron|ATM_uc001pke.1_Missense_Mutation_p.E1467K	NM_000051	NP_000042	Q13315	ATM_HUMAN	ataxia telangiectasia mutated isoform 1	2815	PI3K/PI4K.				cell cycle arrest|cellular response to gamma radiation|DNA damage induced protein phosphorylation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|double-strand break repair via homologous recombination|G2/M transition DNA damage checkpoint|histone mRNA catabolic process|mitotic cell cycle spindle assembly checkpoint|negative regulation of B cell proliferation|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|pre-B cell allelic exclusion|protein autophosphorylation|reciprocal meiotic recombination|replicative senescence	cytoplasmic membrane-bounded vesicle|nucleoplasm	1-phosphatidylinositol-3-kinase activity|ATP binding|DNA binding|DNA-dependent protein kinase activity|identical protein binding|protein complex binding|protein dimerization activity|protein N-terminus binding			haematopoietic_and_lymphoid_tissue(174)|lung(25)|breast(15)|large_intestine(9)|ovary(5)|kidney(5)|central_nervous_system(4)|upper_aerodigestive_tract(1)|stomach(1)|NS(1)	240		all_cancers(61;9.64e-12)|all_epithelial(67;9.97e-08)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		Epithelial(105;9.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.06e-05)|all cancers(92;0.000208)|Colorectal(284;0.116)|OV - Ovarian serous cystadenocarcinoma(223;0.147)		GTCTTTTGAAGAGAAATATGA	0.269		NaN	D|Mis|N|F|S		T-PLL	leukemia|lymphoma|medulloblastoma|glioma		Genes_defective_in_diseases_associated_with_sensitivity_to_DNA_damaging_agents	Ataxia_Telangiectasia	TSP Lung(14;0.12)			0	0	0	0.009096	0	3	67									
C11orf63	79864	broad.mit.edu	37	11	122756667	122756667	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr11:122756667G>A	uc001pym.2	+	2	407	c.110G>A	c.(109-111)CGG>CAG	p.R37Q	C11orf63_uc001pyl.1_Missense_Mutation_p.R37Q	NM_024806	NP_079082	Q6NUN7	CK063_HUMAN	hypothetical protein LOC79864 isoform 1	37										ovary(3)	3		Breast(109;0.00249)|Lung NSC(97;0.0177)|all_lung(97;0.018)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;5.34e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0311)		GACTTACATCGGATTTCAAAA	0.433		NaN											0	0	0	0.012319	0	23	55									
TMEM225	338661	broad.mit.edu	37	11	123753889	123753889	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr11:123753889G>C	uc001pzi.2	-	4	842	c.634C>G	c.(634-636)CTA>GTA	p.L212V		NM_001013743	NP_001013765	Q6GV28	TM225_HUMAN	transmembrane protein 225	212						integral to membrane				upper_aerodigestive_tract(1)|pancreas(1)|skin(1)	3						TTTTTGTTTAGGGAATTCACA	0.408		NaN											0	0	0	0.004007	0	15	72									
ROBO4	54538	broad.mit.edu	37	11	124763844	124763844	+	Silent	SNP	G	G	C			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr11:124763844G>C	uc001qbg.2	-	9	1556	c.1416C>G	c.(1414-1416)GCC>GCG	p.A472A	ROBO4_uc010sas.1_Silent_p.A327A|ROBO4_uc001qbh.2_Silent_p.A362A|ROBO4_uc001qbi.2_Silent_p.A30A|ROBO4_uc010sat.1_Silent_p.A30A	NM_019055	NP_061928	Q8WZ75	ROBO4_HUMAN	roundabout homolog 4, magic roundabout	472					angiogenesis|cell differentiation	integral to membrane	receptor activity			ovary(1)|skin(1)	2	all_hematologic(175;0.215)	Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|Breast(109;0.171)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.5e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0301)		CACCGCAGGTGGCAATGACCT	0.652		NaN											0	0	0	0.001984	0	4	25									
KIRREL3	84623	broad.mit.edu	37	11	126314964	126314964	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr11:126314964C>T	uc001qea.2	-	10	1523	c.1162G>A	c.(1162-1164)GTG>ATG	p.V388M	KIRREL3_uc001qeb.2_Missense_Mutation_p.V388M|KIRREL3_uc001qec.1_Missense_Mutation_p.V388M	NM_032531	NP_115920	Q8IZU9	KIRR3_HUMAN	kin of IRRE like 3 isoform 1	388	Extracellular (Potential).|Ig-like C2-type 4.				hemopoiesis	extracellular region|integral to membrane|plasma membrane	protein binding			ovary(3)	3	all_hematologic(175;0.145)	Lung NSC(97;0.0484)|all_lung(97;0.0522)|Medulloblastoma(222;0.0523)|Breast(109;0.0949)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;6.03e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.12)		TCCTGGCGCACGGATTTGAGG	0.617		NaN											0	0	0	0.00499	0	15	59									
ARHGAP32	9743	broad.mit.edu	37	11	128856559	128856559	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr11:128856559C>T	uc009zcp.2	-	13	1261	c.1261G>A	c.(1261-1263)GAA>AAA	p.E421K	ARHGAP32_uc009zcq.1_Missense_Mutation_p.E381K|ARHGAP32_uc009zco.2_5'UTR|ARHGAP32_uc001qez.2_Missense_Mutation_p.E72K|ARHGAP32_uc001qfb.2_Missense_Mutation_p.E206K	NM_001142685	NP_001136157	A7KAX9	RHG32_HUMAN	Rho GTPase-activating protein isoform 1	421	Rho-GAP.				cell communication|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cell cortex|cell junction|cytosol|dendritic spine|endoplasmic reticulum membrane|endosome membrane|Golgi membrane|postsynaptic density|postsynaptic membrane	GTPase activator activity|phosphatidylinositol binding			lung(3)|ovary(2)	5						GAGTCAAATTCATGGCTGACG	0.453		NaN											0	0	0	0.003163	0	14	49									
ADAMTS15	170689	broad.mit.edu	37	11	130341218	130341218	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr11:130341218G>C	uc010scd.1	+	7	2018	c.2018G>C	c.(2017-2019)GGG>GCG	p.G673A		NM_139055	NP_620686	Q8TE58	ATS15_HUMAN	a disintegrin-like and metalloprotease	673	Cys-rich.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			large_intestine(2)|pancreas(1)|lung(1)|skin(1)	5	all_hematologic(175;0.0429)	Lung NSC(97;0.000601)|Breast(109;0.000962)|all_lung(97;0.00125)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.0631)|Lung(977;0.215)		GACAAGTGTGGGGTGTGTGGG	0.567		NaN											0	0	0	0.006214	0	9	78									
IGSF9B	22997	broad.mit.edu	37	11	133790010	133790010	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr11:133790010G>C	uc001qgx.3	-	18	3841	c.3610C>G	c.(3610-3612)CTG>GTG	p.L1204V		NM_014987	NP_055802	Q9UPX0	TUTLB_HUMAN	immunoglobulin superfamily, member 9B	1204	Pro-rich.|Cytoplasmic (Potential).					integral to membrane|plasma membrane					0	all_hematologic(175;0.127)	all_cancers(12;1.58e-21)|all_epithelial(12;5.17e-16)|all_lung(97;1.6e-05)|Lung NSC(97;3.86e-05)|Breast(109;0.000126)|Medulloblastoma(222;0.0245)|all_neural(223;0.0505)|Esophageal squamous(93;0.0559)		Epithelial(10;7.19e-10)|BRCA - Breast invasive adenocarcinoma(10;9.69e-09)|all cancers(11;1.23e-08)|OV - Ovarian serous cystadenocarcinoma(99;0.00328)|Lung(977;0.221)		CTTTGGGTCAGAGGTGAGAGC	0.711		NaN											0	0	0	0.008361	0	28	93									
IQSEC3	440073	broad.mit.edu	37	12	247681	247681	+	Silent	SNP	G	G	A			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr12:247681G>A	uc001qhw.1	+	1	249	c.243G>A	c.(241-243)TCG>TCA	p.S81S	IQSEC3_uc001qhu.1_Silent_p.S81S|IQSEC3_uc001qht.1_Silent_p.S166S|uc001qhv.1_Intron	NM_015232	NP_056047	Q9UPP2	IQEC3_HUMAN	IQ motif and Sec7 domain 3	384					regulation of ARF protein signal transduction	cytoplasm	ARF guanyl-nucleotide exchange factor activity			central_nervous_system(2)|large_intestine(1)|skin(1)	4	all_cancers(10;0.016)|all_lung(10;0.0222)|all_epithelial(11;0.0262)|Lung NSC(10;0.031)		OV - Ovarian serous cystadenocarcinoma(31;0.00456)	LUAD - Lung adenocarcinoma(1;0.172)|Lung(1;0.179)		TGGTGCGCTCGCCCTCCCTGC	0.697		NaN											0	0	0	0.004672	0	3	5									
FBXL14	144699	broad.mit.edu	37	12	1702939	1702939	+	Silent	SNP	G	G	A			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr12:1702939G>A	uc001qjh.2	-	1	393	c.294C>T	c.(292-294)AGC>AGT	p.S98S	WNT5B_uc009zdq.2_Intron|FBXL14_uc001qji.2_Silent_p.S10S	NM_152441	NP_689654	Q8N1E6	FXL14_HUMAN	F-box and leucine-rich repeat protein 14	98						cytoplasm				ovary(1)	1	Ovarian(42;0.107)		OV - Ovarian serous cystadenocarcinoma(31;0.00115)			TGTAGCAGCCGCTGAGGTTGA	0.652		NaN											0	0	0	0.006122	0	14	75									
NCAPD2	9918	broad.mit.edu	37	12	6634839	6634839	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr12:6634839C>G	uc001qoo.2	+	18	2351	c.2305C>G	c.(2305-2307)CTG>GTG	p.L769V	NCAPD2_uc009zen.1_Missense_Mutation_p.L641V|NCAPD2_uc010sfd.1_Missense_Mutation_p.L724V	NM_014865	NP_055680	Q15021	CND1_HUMAN	non-SMC condensin I complex, subunit D2	769					cell division|mitotic chromosome condensation	condensin core heterodimer|cytoplasm	histone binding			ovary(2)|lung(1)|breast(1)|kidney(1)	5						CTGCTGTCCTCTGGAGCGCTG	0.557		NaN											0	0	0	0.003163	0	13	21									
SPSB2	84727	broad.mit.edu	37	12	6981672	6981672	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr12:6981672C>A	uc001qrl.2	-	2	550	c.394G>T	c.(394-396)GGC>TGC	p.G132C	SPSB2_uc001qrm.2_Missense_Mutation_p.G132C|SPSB2_uc010sfp.1_Missense_Mutation_p.G132C|LRRC23_uc001qrn.1_5'Flank	NM_001146316	NP_001139788	Q99619	SPSB2_HUMAN	splA/ryanodine receptor domain and SOCS box	132	B30.2/SPRY.				intracellular signal transduction	cytoplasm	protein binding			kidney(1)	1						ATGTCCCAGCCCCACGACTCG	0.701		NaN									OREG0021639	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	1	0	1.39806e-14	0.008361	1.63197e-14	23	114									
BHLHE41	79365	broad.mit.edu	37	12	26275715	26275715	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr12:26275715C>T	uc001rhb.2	-	5	1024	c.733G>A	c.(733-735)GAA>AAA	p.E245K		NM_030762	NP_110389	Q9C0J9	BHE41_HUMAN	basic helix-loop-helix domain containing, class	245					cell differentiation|cell proliferation|organ morphogenesis	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity				0						GCCTCGGCTTCGCCGCCGTAG	0.736		NaN											0	0	0	0.004482	0	7	14									
FAM113B	91523	broad.mit.edu	37	12	47629841	47629841	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr12:47629841G>A	uc001rpn.2	+	4	1726	c.995G>A	c.(994-996)CGG>CAG	p.R332Q	FAM113B_uc001rpq.2_Missense_Mutation_p.R332Q	NM_138371	NP_612380	Q96HM7	F113B_HUMAN	hypothetical protein LOC91523	332	Pro-rich.						hydrolase activity	p.R332W(1)		skin(3)|ovary(2)	5	Renal(347;0.138)|Lung SC(27;0.192)					GGAATGCCCCGGTTCCCACAG	0.328		NaN											0	0	0	0.01441	0	37	178									
DDN	23109	broad.mit.edu	37	12	49391444	49391444	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr12:49391444C>G	uc001rsv.1	-	2	1233	c.1215G>C	c.(1213-1215)TGG>TGC	p.W405C	uc001rsw.2_5'Flank	NM_015086	NP_055901	O94850	DEND_HUMAN	dendrin	405	Interaction with ACTN1.					dendritic spine membrane|endoplasmic reticulum membrane|nucleus|perikaryon				large_intestine(1)	1						CTCCGGGAGCCCAGGGTCTGG	0.627		NaN											0	0	0	0.020292	0	12	50									
ITGA7	3679	broad.mit.edu	37	12	56094913	56094913	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr12:56094913C>G	uc001shh.2	-	4	660	c.440G>C	c.(439-441)AGG>ACG	p.R147T	ITGA7_uc001shg.2_Missense_Mutation_p.R147T|ITGA7_uc010sps.1_Missense_Mutation_p.R50T|ITGA7_uc009znx.2_Missense_Mutation_p.R34T	NM_001144996	NP_001138468	Q13683	ITA7_HUMAN	integrin alpha 7 isoform 1 precursor	147	FG-GAP 2.|Extracellular (Potential).				cell-matrix adhesion|integrin-mediated signaling pathway|muscle organ development|regulation of cell shape	integrin complex	receptor activity			ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	5						CACTCGCTGCCTTGCCTCATA	0.592		NaN											0	0	0	0.020292	0	11	202									
HMGA2	8091	broad.mit.edu	37	12	66357034	66357034	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr12:66357034G>A	uc001ssx.2	+	5	1103	c.292G>A	c.(292-294)GAA>AAA	p.E98K		NM_003483	NP_003474	P52926	HMGA2_HUMAN	high mobility group AT-hook 2 isoform a	98					cell division|chromatin organization|mitosis|multicellular organismal development|regulation of growth|transcription, DNA-dependent	chromatin	AT DNA binding		HMGA2/LPP(161)|HMGA2/WIF1_ENST00000286574(14)|HMGA2/RAD51B(11)|HMGA2/NFIB_ENST00000397581(8)|HMGA2/FHIT_ENST00000476844(4)|HMGA2/CCNB1IP1(2)|HMGA2/ALDH2_ENST00000261733(2)|HMGA2/EBF1(2)|HMGA2/LHFP(2)|HMGA2/COX6C(2)	soft_tissue(159)|bone(27)|salivary_gland(22)	208	all_cancers(1;5.78e-46)		GBM - Glioblastoma multiforme(1;0.00179)|LUSC - Lung squamous cell carcinoma(43;0.156)	GBM - Glioblastoma multiforme(28;0.0386)		GGAGGAAACTGAAGAGACATC	0.512		NaN	T	LHFP|RAD51L1|LPP|HEI10|COX6C|CMKOR1|NFIB|ALDH2|CCNB1IP1|EBF1|WIF1|FHIT	lipoma|leiomyoma|pleiomorphic salivary gland adenoma								0	0	0	0.003163	0	12	39									
KRR1	11103	broad.mit.edu	37	12	75905364	75905364	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr12:75905364G>A	uc001sxt.2	-	1	55	c.14C>T	c.(13-15)TCG>TTG	p.S5L	KRR1_uc009zsc.2_Missense_Mutation_p.S5L|KRR1_uc010stx.1_Missense_Mutation_p.S5L	NM_007043	NP_008974	Q13601	KRR1_HUMAN	HIV-1 rev binding protein 2	5					rRNA processing	nucleolus|ribonucleoprotein complex	RNA binding			ovary(1)|pancreas(1)	2						CCGCTCCAGCGAGGGAGACGC	0.532		NaN											0	0	0	0.006214	0	9	49									
GNPTAB	79158	broad.mit.edu	37	12	102158444	102158444	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr12:102158444G>A	uc001tit.2	-	13	2430	c.2251C>T	c.(2251-2253)CAA>TAA	p.Q751*		NM_024312	NP_077288	Q3T906	GNPTA_HUMAN	N-acetylglucosamine-1-phosphate transferase	751					cell differentiation	Golgi membrane|integral to membrane|nucleus	metal ion binding|transcription factor binding|UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity			ovary(1)|skin(1)	2						ATTATAGCTTGATTTTTTATT	0.383		NaN											0	0	0	0.014758	0	5	26									
ALDH1L2	160428	broad.mit.edu	37	12	105440691	105440691	+	Silent	SNP	C	C	T			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr12:105440691C>T	uc001tlc.2	-	14	1870	c.1743G>A	c.(1741-1743)AAG>AAA	p.K581K	ALDH1L2_uc009zuo.2_Silent_p.K36K|ALDH1L2_uc009zup.2_RNA	NM_001034173	NP_001029345	Q3SY69	AL1L2_HUMAN	aldehyde dehydrogenase 1 family, member L2	581	Aldehyde dehydrogenase.				10-formyltetrahydrofolate catabolic process|biosynthetic process	mitochondrion	acyl carrier activity|cofactor binding|formyltetrahydrofolate dehydrogenase activity|hydroxymethyl-, formyl- and related transferase activity|methyltransferase activity|phosphopantetheine binding			skin(1)	1						GTGGCTCTTTCTTGGTGAAGG	0.393		NaN											0	0	0	0.007835	0	35	159									
ANAPC7	51434	broad.mit.edu	37	12	110826320	110826320	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr12:110826320G>C	uc001tqo.2	-	4	620	c.619C>G	c.(619-621)CTA>GTA	p.L207V	ANAPC7_uc001tqp.3_Missense_Mutation_p.L207V	NM_016238	NP_057322	Q9UJX3	APC7_HUMAN	anaphase-promoting complex subunit 7 isoform a	207					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination	anaphase-promoting complex|cytosol|nucleoplasm	protein phosphatase binding				0						TCTCTACCTAGAATGGCATCA	0.373		NaN											0	0	0	0.006214	0	8	62									
TBX5	6910	broad.mit.edu	37	12	114836395	114836395	+	Silent	SNP	G	G	A			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr12:114836395G>A	uc001tvo.2	-	5	988	c.493C>T	c.(493-495)CTG>TTG	p.L165L	TBX5_uc001tvp.2_Silent_p.L165L|TBX5_uc001tvq.2_Silent_p.L115L|TBX5_uc010syv.1_Silent_p.L165L	NM_181486	NP_852259	Q99593	TBX5_HUMAN	T-box 5 isoform 1	165	T-box.				cardiac left ventricle formation|cell migration involved in coronary vasculogenesis|cell-cell signaling|embryonic arm morphogenesis|induction of apoptosis|negative regulation of cardiac muscle cell proliferation|negative regulation of cell migration|negative regulation of epithelial to mesenchymal transition|pericardium development|positive regulation of cardioblast differentiation|positive regulation of transcription from RNA polymerase II promoter|ventricular septum development	cytoplasm|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding			ovary(6)|pancreas(1)|skin(1)	8	Medulloblastoma(191;0.163)|all_neural(191;0.178)			BRCA - Breast invasive adenocarcinoma(302;0.0893)		AATGGGTCCAGGTGGTTGTTG	0.468		NaN											0	0	0	0.014758	0	5	30									
TAOK3	51347	broad.mit.edu	37	12	118590040	118590040	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr12:118590040C>G	uc001twx.2	-	20	2822	c.2527G>C	c.(2527-2529)GAG>CAG	p.E843Q	TAOK3_uc001twv.2_Missense_Mutation_p.E383Q|TAOK3_uc001tww.2_Missense_Mutation_p.E673Q|TAOK3_uc001twy.3_Missense_Mutation_p.E843Q	NM_016281	NP_057365	Q9H2K8	TAOK3_HUMAN	TAO kinase 3	843	Potential.				MAPKKK cascade|negative regulation of JNK cascade|positive regulation of JNK cascade|protein autophosphorylation	mitochondrion|plasma membrane	ATP binding|protein kinase inhibitor activity|protein serine/threonine kinase activity			lung(5)|central_nervous_system(1)	6	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					ACCTTCTGCTCAAGGTGTGCT	0.468		NaN											0	0	0	0.008291	0	8	67									
TAOK3	51347	broad.mit.edu	37	12	118599765	118599765	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr12:118599765G>T	uc001twx.2	-	18	2262	c.1967C>A	c.(1966-1968)ACC>AAC	p.T656N	TAOK3_uc001twv.2_Missense_Mutation_p.T196N|TAOK3_uc001tww.2_Missense_Mutation_p.T486N|TAOK3_uc001twy.3_Missense_Mutation_p.T656N	NM_016281	NP_057365	Q9H2K8	TAOK3_HUMAN	TAO kinase 3	656					MAPKKK cascade|negative regulation of JNK cascade|positive regulation of JNK cascade|protein autophosphorylation	mitochondrion|plasma membrane	ATP binding|protein kinase inhibitor activity|protein serine/threonine kinase activity			lung(5)|central_nervous_system(1)	6	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					TAGCTCTCGGGTGGACTCGTC	0.512		NaN											1	0	2.4624e-09	0.008871	2.80882e-09	16	62									
GCN1L1	10985	broad.mit.edu	37	12	120597747	120597747	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr12:120597747G>C	uc001txo.2	-	24	2644	c.2631C>G	c.(2629-2631)ATC>ATG	p.I877M		NM_006836	NP_006827	Q92616	GCN1L_HUMAN	GCN1 general control of amino-acid synthesis	877					regulation of translation	ribosome	protein binding|translation factor activity, nucleic acid binding			ovary(4)	4	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					CCAAAACAGGGATGTACTGGG	0.592		NaN											0	0	0	0.004007	0	14	88									
CLIP1	6249	broad.mit.edu	37	12	122812709	122812709	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr12:122812709C>T	uc001ucg.1	-	16	3140	c.3034G>A	c.(3034-3036)GAA>AAA	p.E1012K	CLIP1_uc001uch.1_Missense_Mutation_p.E1001K|CLIP1_uc001uci.1_Missense_Mutation_p.E966K|CLIP1_uc001ucj.1_Missense_Mutation_p.E587K	NM_002956	NP_002947	P30622	CLIP1_HUMAN	restin isoform a	1012	Potential.				mitotic prometaphase|positive regulation of microtubule polymerization	centrosome|cytosol|endosome|intermediate filament|kinetochore	nucleic acid binding|protein homodimerization activity|zinc ion binding			ovary(2)|breast(1)	3	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.81e-05)|Epithelial(86;6.85e-05)|BRCA - Breast invasive adenocarcinoma(302;0.226)		ATTTTCTTTTCCTGCAGAGAC	0.493		NaN											0	0	0	0.009535	0	19	121									
CCDC62	84660	broad.mit.edu	37	12	123297940	123297940	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr12:123297940G>A	uc001udc.2	+	11	2120	c.1975G>A	c.(1975-1977)GAG>AAG	p.E659K	CCDC62_uc010tah.1_RNA|CCDC62_uc001udf.2_Missense_Mutation_p.E659K|CCDC62_uc001ude.2_Missense_Mutation_p.E420K	NM_201435	NP_958843	Q6P9F0	CCD62_HUMAN	coiled-coil domain containing 62 isoform b	659						cytoplasm|nucleus				ovary(2)|large_intestine(1)|pancreas(1)|skin(1)	5	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;6.51e-06)|Epithelial(86;2.65e-05)|BRCA - Breast invasive adenocarcinoma(302;0.206)		CATCAGCCATGAGAATCTCAC	0.498		NaN											0	0	0	0.006214	0	10	59									
POLE	5426	broad.mit.edu	37	12	133218913	133218913	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr12:133218913G>A	uc001uks.1	-	38	5067	c.5023C>T	c.(5023-5025)CGC>TGC	p.R1675C	POLE_uc001ukq.1_5'Flank|POLE_uc001ukr.1_Missense_Mutation_p.R479C|POLE_uc010tbq.1_RNA	NM_006231	NP_006222	Q07864	DPOE1_HUMAN	DNA-directed DNA polymerase epsilon	1675					base-excision repair, gap-filling|DNA synthesis involved in DNA repair|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	nucleoplasm	chromatin binding|DNA binding|DNA-directed DNA polymerase activity|nucleotide binding|protein binding|zinc ion binding			ovary(3)|skin(3)|lung(1)|central_nervous_system(1)	8	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0416)		OV - Ovarian serous cystadenocarcinoma(86;5.22e-08)|Epithelial(86;4.03e-07)|all cancers(50;1.18e-05)		TGGAGGTGGCGGGCAAAGAAG	0.597		NaN						DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					0	0	0	0.004656	0	26	45									
FNDC3A	22862	broad.mit.edu	37	13	49760119	49760119	+	Missense_Mutation	SNP	A	A	C			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr13:49760119A>C	uc001vcm.2	+	15	1942	c.1637A>C	c.(1636-1638)GAA>GCA	p.E546A	FNDC3A_uc001vcn.2_Missense_Mutation_p.E546A|FNDC3A_uc001vco.2_RNA|FNDC3A_uc001vcp.1_Missense_Mutation_p.E472A|FNDC3A_uc001vcq.2_Missense_Mutation_p.E490A	NM_001079673	NP_001073141	Q9Y2H6	FND3A_HUMAN	fibronectin type III domain containing 3A	546	Fibronectin type-III 3.					Golgi membrane|integral to membrane				lung(2)	2		all_lung(13;7.44e-08)|Lung NSC(96;4.08e-06)|Breast(56;0.000111)|Prostate(109;0.00174)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|Lung SC(185;0.187)|all_neural(104;0.19)	KIRC - Kidney renal clear cell carcinoma(9;0.206)	GBM - Glioblastoma multiforme(99;2.94e-09)		TACAACTCAGAAGGTAAAAGT	0.353		NaN											0	0	0	0.001984	0	7	22									
GAS6	2621	broad.mit.edu	37	13	114530137	114530137	+	Missense_Mutation	SNP	T	T	C			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr13:114530137T>C	uc001vud.2	-	12	1462	c.1309A>G	c.(1309-1311)ATA>GTA	p.I437V	GAS6_uc001vug.2_Missense_Mutation_p.I138V|GAS6_uc001vuf.2_Missense_Mutation_p.I164V	NM_000820	NP_000811	Q14393	GAS6_HUMAN	growth arrest-specific 6 isoform 1 precursor	480	Laminin G-like 1.				cell proliferation|leukocyte migration|peptidyl-glutamic acid carboxylation|platelet activation|platelet degranulation|positive regulation of ERK1 and ERK2 cascade|positive regulation of fibroblast proliferation|post-translational protein modification|proteolysis|regulation of growth	endoplasmic reticulum lumen|extracellular space|Golgi lumen|platelet alpha granule lumen	calcium ion binding|receptor agonist activity			central_nervous_system(4)	4	Lung NSC(43;0.00976)|all_neural(89;0.0337)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.0176)|all_epithelial(44;0.0104)|all_lung(25;0.0249)|Lung NSC(25;0.0908)|Breast(118;0.188)				CGAGGGTTTATCTGGAAAGGC	0.592		NaN											0	0	0	0.010818	0	27	79									
DCAF11	80344	broad.mit.edu	37	14	24584853	24584853	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr14:24584853C>G	uc001wlv.2	+	2	330	c.50C>G	c.(49-51)TCC>TGC	p.S17C	NRL_uc001wlq.2_5'Flank|DCAF11_uc001wlw.2_Missense_Mutation_p.S17C|DCAF11_uc001wlz.2_5'UTR|DCAF11_uc001wly.2_5'UTR|DCAF11_uc001wme.2_Missense_Mutation_p.S17C|DCAF11_uc010tny.1_5'UTR|DCAF11_uc001wmd.2_Missense_Mutation_p.S17C|DCAF11_uc001wmc.2_5'UTR|DCAF11_uc001wmb.3_Missense_Mutation_p.S17C|DCAF11_uc001wma.3_Missense_Mutation_p.S17C	NM_001163484	NP_001156956	Q8TEB1	DCA11_HUMAN	DDB1 and CUL4 associated factor 11 isoform 1	17						CUL4 RING ubiquitin ligase complex	protein binding				0						GGAGACCCCTCCGAGGGCTTG	0.617		NaN											0	0	0	0.01441	0	34	70									
G2E3	55632	broad.mit.edu	37	14	31085657	31085657	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr14:31085657G>C	uc001wqk.2	+	15	2192	c.2038G>C	c.(2038-2040)GAG>CAG	p.E680Q	G2E3_uc010tpf.1_Missense_Mutation_p.E634Q|G2E3_uc001wql.1_Missense_Mutation_p.E192Q	NM_017769	NP_060239	Q7L622	G2E3_HUMAN	G2/M-phase specific E3 ubiquitin ligase	680	HECT.				apoptosis|multicellular organismal development|protein modification process	Golgi apparatus|nucleolus	acid-amino acid ligase activity|protein binding|zinc ion binding			ovary(2)|skin(1)	3						TACATATAAAGAGTTTCAAGA	0.333		NaN											0	0	0	0.006214	0	8	19									
LRFN5	145581	broad.mit.edu	37	14	42361055	42361055	+	Missense_Mutation	SNP	T	T	C			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr14:42361055T>C	uc001wvm.2	+	4	3186	c.1988T>C	c.(1987-1989)GTT>GCT	p.V663A	LRFN5_uc010ana.2_Intron	NM_152447	NP_689660	Q96NI6	LRFN5_HUMAN	leucine rich repeat and fibronectin type III	663	Cytoplasmic (Potential).					integral to membrane				ovary(5)|pancreas(2)|central_nervous_system(1)	8			LUAD - Lung adenocarcinoma(50;0.0223)|Lung(238;0.0728)	GBM - Glioblastoma multiforme(112;0.00847)		GTCACAAATGTTGAATCCCAA	0.483		NaN								HNSCC(30;0.082)			0	0	0	0.013537	0	11	28									
SPATA7	55812	broad.mit.edu	37	14	88892876	88892876	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr14:88892876C>G	uc001xwq.2	+	6	824	c.673C>G	c.(673-675)CTT>GTT	p.L225V	SPATA7_uc001xwr.2_Missense_Mutation_p.L193V|SPATA7_uc001xws.2_Missense_Mutation_p.L161V|SPATA7_uc001xwt.2_Missense_Mutation_p.L119V|SPATA7_uc001xwu.2_5'Flank	NM_018418	NP_060888	Q9P0W8	SPAT7_HUMAN	spermatogenesis-associated protein 7 isoform a	225					response to stimulus|visual perception					ovary(1)	1						CAGTGGGGATCTTTTGGATAA	0.438		NaN											0	0	0	0.010504	0	16	75									
BTBD7	55727	broad.mit.edu	37	14	93712182	93712182	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr14:93712182C>T	uc001ybo.2	-	10	2898	c.2572G>A	c.(2572-2574)GAG>AAG	p.E858K	BTBD7_uc010aur.2_Missense_Mutation_p.E383K|BTBD7_uc010two.1_Missense_Mutation_p.E678K|BTBD7_uc001ybp.2_Missense_Mutation_p.E507K	NM_001002860	NP_001002860	Q9P203	BTBD7_HUMAN	BTB (POZ) domain containing 7 isoform 1	858										pancreas(1)	1		all_cancers(154;0.08)		Epithelial(152;0.196)|COAD - Colon adenocarcinoma(157;0.212)|all cancers(159;0.223)		ACTTGCTTCTCAGAtgctgct	0.448		NaN											0	0	0	0.016723	0	14	43									
ATG2B	55102	broad.mit.edu	37	14	96784135	96784135	+	Missense_Mutation	SNP	G	G	C	rs113424169		TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr14:96784135G>C	uc001yfi.2	-	19	3302	c.2937C>G	c.(2935-2937)TTC>TTG	p.F979L		NM_018036	NP_060506	Q96BY7	ATG2B_HUMAN	ATG2 autophagy related 2 homolog B	979										ovary(1)|kidney(1)|skin(1)	3		all_cancers(154;0.0462)|all_epithelial(191;0.123)|Melanoma(154;0.155)		Epithelial(152;0.21)|COAD - Colon adenocarcinoma(157;0.244)		AAATATTCTCGAATGTCTCCA	0.368		NaN											0	0	0	0.00623	0	32	83									
AHNAK2	113146	broad.mit.edu	37	14	105413989	105413989	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr14:105413989G>A	uc010axc.1	-	7	7919	c.7799C>T	c.(7798-7800)GCG>GTG	p.A2600V	AHNAK2_uc001ypx.2_Missense_Mutation_p.A2500V	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	2600						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			TGTCACTTCCGCCTTGGGGCC	0.622		NaN											0	0	0	0.01441	0	41	217									
C15orf55	256646	broad.mit.edu	37	15	34646669	34646669	+	Silent	SNP	C	C	G			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr15:34646669C>G	uc001zif.2	+	5	1169	c.1014C>G	c.(1012-1014)GCC>GCG	p.A338A	C15orf55_uc010ucc.1_Silent_p.A366A|C15orf55_uc010ucd.1_Silent_p.A356A	NM_175741	NP_786883	Q86Y26	NUT_HUMAN	nuclear protein in testis	338						cytoplasm|nucleus			BRD4_ENST00000263377/C15orf55(24)|BRD3/C15orf55(3)	midline_organs(25)|ovary(2)|lung(2)|skin(1)	30		all_lung(180;2.78e-08)		all cancers(64;4.53e-18)|GBM - Glioblastoma multiforme(113;8.29e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0249)		AGAAGGCAGCCTCCAAGACAC	0.557		NaN	T	BRD3|BRD4	lethal midline carcinoma								0	0	0	0.012319	0	19	92									
PPIB	5479	broad.mit.edu	37	15	64454323	64454323	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr15:64454323C>A	uc002and.2	-	2	335	c.166G>T	c.(166-168)GAT>TAT	p.D56Y	PPIB_uc010bgx.1_Missense_Mutation_p.D48Y	NM_000942	NP_000933	P23284	PPIB_HUMAN	peptidylprolyl isomerase B precursor	56	PPIase cyclophilin-type.				protein folding	endoplasmic reticulum lumen|melanosome	peptide binding|peptidyl-prolyl cis-trans isomerase activity|unfolded protein binding				0					L-Proline(DB00172)	CGGCCTACATCTTCATCTCCA	0.463		NaN											1	0	1.67211e-32	0.01441	1.99061e-32	44	157									
ISG20	3669	broad.mit.edu	37	15	89182733	89182733	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr15:89182733G>C	uc002bmv.1	+	2	429	c.136G>C	c.(136-138)GAG>CAG	p.E46Q	ISG20_uc002bmu.1_Intron|ISG20_uc002bmw.1_RNA|ISG20_uc010upn.1_RNA	NM_002201	NP_002192	Q96AZ6	ISG20_HUMAN	interferon stimulated exonuclease	46					cell proliferation|DNA catabolic process, exonucleolytic|response to virus|RNA catabolic process|type I interferon-mediated signaling pathway	PML body	3'-5'-exoribonuclease activity|exoribonuclease II activity|metal ion binding|RNA binding|single-stranded DNA specific 3'-5' exodeoxyribonuclease activity				0	Lung NSC(78;0.0554)|all_lung(78;0.103)		BRCA - Breast invasive adenocarcinoma(143;0.12)			CATCCGGCCTGAGGGAGAGAT	0.642		NaN											0	0	0	0.007413	0	15	117									
HDDC3	374659	broad.mit.edu	37	15	91475081	91475081	+	Nonsense_Mutation	SNP	C	C	A			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr15:91475081C>A	uc002bqf.3	-	3	266	c.262G>T	c.(262-264)GAG>TAG	p.E88*	UNC45A_uc002bqd.2_Intron|HDDC3_uc002bqe.3_Nonsense_Mutation_p.E88*	NM_198527	NP_940929	Q8N4P3	MESH1_HUMAN	HD domain containing 3	88	HD.						guanosine-3',5'-bis(diphosphate) 3'-diphosphatase activity|metal ion binding|phosphoric diester hydrolase activity			ovary(1)	1	Lung NSC(78;0.0771)|all_lung(78;0.137)		Lung(145;0.189)			TCTGTTACCTCCTCCACCAGG	0.627		NaN									OREG0023475	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	1	0	1.05317e-09	0.020292	1.21054e-09	13	75									
WDR90	197335	broad.mit.edu	37	16	716521	716521	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr16:716521G>T	uc002cii.1	+	38	4861	c.4807G>T	c.(4807-4809)GTC>TTC	p.V1603F	WDR90_uc002cij.1_Intron|WDR90_uc002cil.1_RNA|WDR90_uc002cin.1_Missense_Mutation_p.V218F|WDR90_uc010uul.1_Intron|WDR90_uc002cio.1_Missense_Mutation_p.V202F|WDR90_uc010bqx.1_Intron|RHOT2_uc010uum.1_5'Flank|RHOT2_uc002cip.2_5'Flank|RHOT2_uc002ciq.2_5'Flank	NM_145294	NP_660337	Q96KV7	WDR90_HUMAN	WD repeat domain 90	1603	WD 20.									ovary(1)	1		Hepatocellular(780;0.0218)				GCGGGTCAGCGTCTGGGCCTC	0.622		NaN											1	0	7.45023e-12	0.010504	8.66305e-12	18	51									
MKL2	57496	broad.mit.edu	37	16	14345773	14345773	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr16:14345773G>A	uc010uza.1	+	14	2613	c.2458G>A	c.(2458-2460)GCC>ACC	p.A820T	MKL2_uc002dcg.2_Missense_Mutation_p.A770T|MKL2_uc002dcj.2_Missense_Mutation_p.A65T	NM_014048	NP_054767	Q9ULH7	MKL2_HUMAN	megakaryoblastic leukemia 2 protein	809					cell differentiation|muscle organ development|positive regulation of striated muscle tissue development|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		identical protein binding|nucleic acid binding|transcription coactivator activity			ovary(3)|kidney(1)|pancreas(1)	5						GAGACATCCTGCCCCAGCTGT	0.423		NaN											0	0	0	0.009535	0	26	115									
ATP2A1	487	broad.mit.edu	37	16	28914646	28914646	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr16:28914646G>A	uc002dro.1	+	21	3049	c.2865G>A	c.(2863-2865)ATG>ATA	p.M955I	uc010vct.1_Intron|ATP2A1_uc002drn.1_Missense_Mutation_p.M955I|ATP2A1_uc002drp.1_Missense_Mutation_p.M830I	NM_173201	NP_775293	O14983	AT2A1_HUMAN	ATPase, Ca++ transporting, fast twitch 1 isoform	955	Lumenal (By similarity).				apoptosis in response to endoplasmic reticulum stress|apoptotic mitochondrial changes|ATP biosynthetic process|calcium ion import|elevation of endoplasmic reticulum calcium ion concentration|elevation of mitochondrial calcium ion concentration|maintenance of mitochondrion location|negative regulation of striated muscle contraction|platelet activation|positive regulation of fast-twitch skeletal muscle fiber contraction|reduction of endoplasmic reticulum calcium ion concentration|relaxation of skeletal muscle|response to endoplasmic reticulum stress	endoplasmic reticulum membrane|ER-Golgi intermediate compartment|H zone|I band|microsome|perinuclear region of cytoplasm|platelet dense tubular network membrane|sarcoplasmic reticulum|sarcoplasmic reticulum membrane	ATP binding|ATP binding|calcium ion binding|calcium ion binding|calcium-transporting ATPase activity|protein homodimerization activity			ovary(2)|central_nervous_system(1)|pancreas(1)	4						TGCCCCAGATGATCTTCAAGC	0.637		NaN											0	0	0	0.008871	0	17	259									
QPRT	23475	broad.mit.edu	37	16	29708422	29708422	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr16:29708422G>A	uc002dto.2	+	3	733	c.655G>A	c.(655-657)GTC>ATC	p.V219I	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|QPRT_uc010vdu.1_RNA	NM_014298	NP_055113	Q15274	NADC_HUMAN	quinolinate phosphoribosyltransferase	219					protein oligomerization|quinolinate catabolic process|water-soluble vitamin metabolic process	cytosol	nicotinate-nucleotide diphosphorylase (carboxylating) activity|protein homodimerization activity				0					Niacin(DB00627)	TGCCGACCTTGTCCTGCTGGA	0.642		NaN											0	0	0	0.00308	0	6	47									
MVP	9961	broad.mit.edu	37	16	29855914	29855914	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr16:29855914G>T	uc002dui.2	+	11	1819	c.1735G>T	c.(1735-1737)GTG>TTG	p.V579L	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|MVP_uc002duj.2_Missense_Mutation_p.V579L|MVP_uc010vea.1_Missense_Mutation_p.V173L	NM_005115	NP_005106	Q14764	MVP_HUMAN	major vault protein	579					mRNA transport|protein transport|response to drug|transmembrane transport	cytoplasm|nuclear pore|ribonucleoprotein complex	protein binding			skin(2)|ovary(1)|central_nervous_system(1)	4						CGCATCCCGGGTGCGGGGGGC	0.562		NaN											1	0	3.65916e-55	0.01441	4.40863e-55	157	101									
SETD1A	9739	broad.mit.edu	37	16	30992428	30992428	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr16:30992428G>T	uc002ead.1	+	17	5425	c.4739G>T	c.(4738-4740)TGG>TTG	p.W1580L		NM_014712	NP_055527	O15047	SET1A_HUMAN	SET domain containing 1A	1580	SET.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nuclear speck|Set1C/COMPASS complex	histone-lysine N-methyltransferase activity|nucleotide binding|protein binding|RNA binding			ovary(2)|skin(1)	3						ATCCACGAGTGGGGTCTGTTT	0.612		NaN											1	0	5.04308e-16	0.00623	5.93303e-16	35	227									
CDH15	1013	broad.mit.edu	37	16	89260217	89260217	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr16:89260217G>C	uc002fmt.2	+	13	2124	c.2047G>C	c.(2047-2049)GGA>CGA	p.G683R		NM_004933	NP_004924	P55291	CAD15_HUMAN	cadherin 15 preproprotein	683	Cytoplasmic (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion|muscle cell differentiation|positive regulation of muscle cell differentiation	integral to membrane|plasma membrane	calcium ion binding			skin(1)	1				BRCA - Breast invasive adenocarcinoma(80;0.0261)		CCTGCCTCTGGGACCGCCGCC	0.697		NaN											0	0	0	0.001168	0	5	40									
TUBB3	10381	broad.mit.edu	37	16	90001364	90001364	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr16:90001364G>A	uc002fph.1	+	4	570	c.505G>A	c.(505-507)GTC>ATC	p.V169I	TUBB3_uc002fpf.2_Missense_Mutation_p.V516I|TUBB3_uc010ciz.1_Missense_Mutation_p.V97I|TUBB3_uc002fpg.1_Missense_Mutation_p.V23I|TUBB3_uc002fpi.1_Missense_Mutation_p.V97I|TUBB3_uc002fpj.1_Missense_Mutation_p.V97I|TUBB3_uc010cjb.1_Missense_Mutation_p.V23I|TUBB3_uc002fpk.1_Missense_Mutation_p.V23I	NM_006086	NP_006077	Q13509	TBB3_HUMAN	tubulin, beta, 4	169					'de novo' posttranslational protein folding|axon guidance|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|structural molecule activity			ovary(2)|pancreas(1)	3		all_cancers(9;1.69e-11)|Lung NSC(15;8.94e-06)|all_lung(18;1.39e-05)|all_neural(9;0.00581)|all_hematologic(23;0.0194)		BRCA - Breast invasive adenocarcinoma(80;0.0273)		CACCTTCAGCGTCGTGCCCTC	0.627		NaN											0	0	0	0.01441	0	53	187									
PELP1	27043	broad.mit.edu	37	17	4578480	4578480	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr17:4578480G>A	uc002fyi.3	-	11	1394	c.1168C>T	c.(1168-1170)CGG>TGG	p.R390W	PELP1_uc010vsf.1_Missense_Mutation_p.R243W	NM_014389	NP_055204	Q8IZL8	PELP1_HUMAN	proline, glutamic acid and leucine rich protein	390					transcription, DNA-dependent	cytoplasm|MLL1 complex	protein binding			ovary(1)|central_nervous_system(1)	2						CGCAAGAGCCGGCTTCCACAC	0.612		NaN											0	0	0	0.004672	0	3	20									
ARRB2	409	broad.mit.edu	37	17	4619828	4619828	+	Silent	SNP	A	A	C			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr17:4619828A>C	uc002fyj.2	+	5	510	c.282A>C	c.(280-282)CCA>CCC	p.P94P	ARRB2_uc002fyk.2_Silent_p.P79P|ARRB2_uc002fyl.2_Silent_p.P94P|ARRB2_uc010vsg.1_Silent_p.P94P|ARRB2_uc002fym.2_Silent_p.P79P|ARRB2_uc002fyn.2_5'UTR|ARRB2_uc010ckq.2_5'UTR|ARRB2_uc002fyo.2_5'Flank	NM_004313	NP_004304	P32121	ARRB2_HUMAN	arrestin, beta 2 isoform 1	94					cell chemotaxis|desensitization of G-protein coupled receptor protein signaling pathway by arrestin|G-protein coupled receptor internalization|negative regulation of natural killer cell mediated cytotoxicity|negative regulation of NF-kappaB transcription factor activity|negative regulation of protein ubiquitination|platelet activation|positive regulation of ERK1 and ERK2 cascade|proteasomal ubiquitin-dependent protein catabolic process|protein transport|protein ubiquitination|transcription from RNA polymerase II promoter|transforming growth factor beta receptor signaling pathway	coated pit|cytoplasmic membrane-bounded vesicle|cytosol|nucleus|plasma membrane	angiotensin receptor binding|ubiquitin protein ligase binding				0						TGCCCAACCCACCCCGGCCCC	0.667		NaN											0	0	0	0.013726	0	13	60									
CXCL16	58191	broad.mit.edu	37	17	4642109	4642109	+	Silent	SNP	C	C	G			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr17:4642109C>G	uc002fyr.3	-	2	775	c.243G>C	c.(241-243)CTG>CTC	p.L81L	CXCL16_uc002fyq.3_5'Flank|CXCL16_uc002fys.3_Silent_p.L81L|ZMYND15_uc002fyv.2_5'Flank|ZMYND15_uc002fyt.2_5'Flank|ZMYND15_uc002fyu.2_5'Flank	NM_022059	NP_071342	Q9H2A7	CXL16_HUMAN	chemokine (C-X-C motif) ligand 16	62	Extracellular (Potential).|Chemokine.				lymphocyte chemotaxis|positive regulation of cell growth|positive regulation of cell migration|receptor-mediated endocytosis|response to interferon-gamma|response to tumor necrosis factor	extracellular space|integral to membrane|plasma membrane	chemokine activity|low-density lipoprotein receptor activity|scavenger receptor activity				0						GGTAAGCTCTCAGGTGTTTCC	0.552		NaN											0	0	0	0.00499	0	12	43									
ASGR1	432	broad.mit.edu	37	17	7077715	7077715	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr17:7077715C>G	uc002ges.3	-	6	830	c.420G>C	c.(418-420)CAG>CAC	p.Q140H	ASGR1_uc010clx.1_Missense_Mutation_p.Q39H	NM_001671	NP_001662	P07306	ASGR1_HUMAN	asialoglycoprotein receptor 1	140	Extracellular (Probable).				receptor-mediated endocytosis	integral to plasma membrane	asialoglycoprotein receptor activity|metal ion binding|sugar binding			breast(1)|central_nervous_system(1)	2						GCGCCGCCATCTGACAGCTCA	0.682		NaN											0	0	0	0.004007	0	16	20									
TP53	7157	broad.mit.edu	37	17	7577538	7577538	+	Missense_Mutation	SNP	C	C	T	rs11540652		TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr17:7577538C>T	uc002gim.2	-	7	937	c.743G>A	c.(742-744)CGG>CAG	p.R248Q	TP53_uc002gig.1_Missense_Mutation_p.R248Q|TP53_uc002gih.2_Missense_Mutation_p.R248Q|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.R116Q|TP53_uc010cng.1_Missense_Mutation_p.R116Q|TP53_uc002gii.1_Missense_Mutation_p.R116Q|TP53_uc010cnh.1_Missense_Mutation_p.R248Q|TP53_uc010cni.1_Missense_Mutation_p.R248Q|TP53_uc002gij.2_Missense_Mutation_p.R248Q|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.R155Q|TP53_uc002gio.2_Missense_Mutation_p.R116Q	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	248	|Interaction with HIPK1 (By similarity).|Interacts with the 53BP2 SH3 domain.|Interaction with AXIN1 (By similarity).		R -> W (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> P (in sporadic cancers; somatic mutation).|R -> G (in sporadic cancers; somatic mutation).|R -> L (in sporadic cancers; somatic mutation).|NR -> KW (in sporadic cancers; somatic mutation).|R -> C (in a sporadic cancer; somatic mutation).|NR -> IP (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R248Q(523)|p.R248W(443)|p.R248L(63)|p.R248P(12)|p.R248G(11)|p.R248R(10)|p.0?(7)|p.R155Q(4)|p.N247_R248delNR(2)|p.N247_R248>KW(2)|p.M246_P250delMNRRP(2)|p.R248fs*97(2)|p.R248_P250delRRP(1)|p.N247_R249delNRR(1)|p.N247_P250delNRRP(1)|p.R249fs*96(1)|p.R248C(1)|p.G245fs*14(1)|p.N247_R248>IP(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GATGGGCCTCCGGTTCATGCC	0.572	R248Q(KASUMI1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(HS683_CENTRAL_NERVOUS_SYSTEM)|R248Q(NAMALWA_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(HCC1143_BREAST)|R248Q(BL41_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(SKUT1_SOFT_TISSUE)|R248Q(HSC4_UPPER_AERODIGESTIVE_TRACT)|R248Q(HEC1A_ENDOMETRIUM)|R248Q(SF295_CENTRAL_NERVOUS_SYSTEM)|R248Q(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(NUDHL1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(WSUDLCL2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(NCIN87_STOMACH)|R248Q(P12ICHIKAWA_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(DB_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(RT112_URINARY_TRACT)|R248Q(PF382_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(PANC0203_PANCREAS)|R248Q(EM2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(SEM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(CI1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(MOLM6_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(NIHOVCAR3_OVARY)|R248Q(CA46_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(SUPT1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(SW1463_LARGE_INTESTINE)|R248Q(HCC70_BREAST)|R248Q(KYSE150_OESOPHAGUS)|R248Q(NB4_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(NCIH211_LUNG)|R248Q(KYO1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(PC14_LUNG)	111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			0	0	0	0.01441	0	52	40									
DNAH2	146754	broad.mit.edu	37	17	7702490	7702490	+	Missense_Mutation	SNP	T	T	C			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr17:7702490T>C	uc002giu.1	+	55	8643	c.8629T>C	c.(8629-8631)TAC>CAC	p.Y2877H		NM_020877	NP_065928	Q9P225	DYH2_HUMAN	dynein heavy chain domain 3	2877	AAA 4 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(6)|skin(6)|central_nervous_system(1)	13		all_cancers(10;4.66e-07)|Prostate(122;0.081)				CCTCTTCGCCTACCTCATTGA	0.592		NaN											0	0	0	0.004672	0	3	68									
MYH10	4628	broad.mit.edu	37	17	8397110	8397110	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr17:8397110C>G	uc002gll.2	-	30	4153	c.4057G>C	c.(4057-4059)GAG>CAG	p.E1353Q	MYH10_uc002glm.2_Missense_Mutation_p.E1384Q|MYH10_uc010cnx.2_Missense_Mutation_p.E1362Q	NM_005964	NP_005955	P35580	MYH10_HUMAN	myosin, heavy polypeptide 10, non-muscle	1353	Potential.				actin filament-based movement|axon guidance|cytokinesis after mitosis|regulation of cell shape	cell cortex|cleavage furrow|midbody|myosin complex|stress fiber	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(2)	2						TCCTCCTCCTCCTGCTGCTCC	0.587		NaN											0	0	0	0.009096	0	3	49									
MYH3	4621	broad.mit.edu	37	17	10538231	10538231	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr17:10538231C>T	uc002gmq.1	-	30	4359	c.4282G>A	c.(4282-4284)GAT>AAT	p.D1428N		NM_002470	NP_002461	P11055	MYH3_HUMAN	myosin, heavy chain 3, skeletal muscle,	1428	Potential.				muscle filament sliding|muscle organ development	cytosol|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(4)|central_nervous_system(2)|pancreas(1)	7						ACCATCAGATCCTCCACCTCT	0.537		NaN											0	0	0	0.01441	0	53	36									
UTP6	55813	broad.mit.edu	37	17	30205295	30205295	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr17:30205295G>C	uc002hgr.2	-	13	1182	c.1099C>G	c.(1099-1101)CTG>GTG	p.L367V	UTP6_uc002hgq.2_Missense_Mutation_p.L183V|UTP6_uc010cst.2_Missense_Mutation_p.L216V	NM_018428	NP_060898	Q9NYH9	UTP6_HUMAN	hepatocellular carcinoma-associated antigen 66	367					rRNA processing	nucleolus	binding			ovary(1)	1		all_hematologic(16;0.0149)|Ovarian(249;0.021)|Myeloproliferative disorder(56;0.0255)|Acute lymphoblastic leukemia(14;0.0257)|Breast(31;0.231)				CATTCTGACAGAAGCTTCAGT	0.408		NaN											0	0	0	0.01892	0	17	77									
UTP18	51096	broad.mit.edu	37	17	49340655	49340655	+	Silent	SNP	G	G	C			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr17:49340655G>C	uc002its.2	+	2	412	c.363G>C	c.(361-363)TCG>TCC	p.S121S		NM_016001	NP_057085	Q9Y5J1	UTP18_HUMAN	UTP18, small subunit processome component	121					rRNA processing	nucleolus					0			BRCA - Breast invasive adenocarcinoma(22;2.09e-07)			ATGAAGACTCGGGTGACTCAG	0.438		NaN											0	0	0	0.010729	0	10	46									
ANKFN1	162282	broad.mit.edu	37	17	54431282	54431282	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr17:54431282C>G	uc002iun.1	+	5	520	c.485C>G	c.(484-486)CCA>CGA	p.P162R		NM_153228	NP_694960	Q8N957	ANKF1_HUMAN	ankyrin-repeat and fibronectin type III domain	162	ANK 1.									large_intestine(1)|ovary(1)	2						CAGTACACACCAGAAGAACTT	0.493		NaN											0	0	0	0.008871	0	17	58									
KIAA0195	9772	broad.mit.edu	37	17	73486837	73486837	+	Nonsense_Mutation	SNP	C	C	T			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr17:73486837C>T	uc002jnz.3	+	11	1401	c.1126C>T	c.(1126-1128)CAG>TAG	p.Q376*	KIAA0195_uc010wsa.1_Nonsense_Mutation_p.Q386*|KIAA0195_uc010wsb.1_Nonsense_Mutation_p.Q28*	NM_014738	NP_055553	Q12767	K0195_HUMAN	hypothetical protein LOC9772	376					ATP biosynthetic process|cation transport	integral to membrane	ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism			ovary(1)	1	all_cancers(13;3.15e-09)|all_epithelial(9;5.94e-10)|Breast(9;1.85e-09)|all_lung(278;0.246)		all cancers(21;5.01e-07)|Epithelial(20;5e-06)|Lung(188;0.0809)|LUSC - Lung squamous cell carcinoma(166;0.154)			TGTCTCCTCTCAGGTACAACA	0.557		NaN											0	0	0	0.016723	0	12	44									
ARL16	339231	broad.mit.edu	37	17	79650829	79650829	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr17:79650829C>G	uc002kbf.2	-	1	126	c.27G>C	c.(25-27)TTG>TTC	p.L9F	ARL16_uc002kbe.2_5'Flank|HGS_uc010wus.1_5'Flank|HGS_uc002kbg.2_5'Flank	NM_001040025	NP_001035114	Q0P5N6	ARL16_HUMAN	ADP-ribosylation factor-like 16	9							GTP binding				0	all_neural(118;0.0878)|all_lung(278;0.23)		BRCA - Breast invasive adenocarcinoma(99;0.0101)|OV - Ovarian serous cystadenocarcinoma(97;0.0739)			CGCCGCGGCTCAAGGCCCGCC	0.637		NaN											0	0	0	0.009096	0	4	28									
ZNF750	79755	broad.mit.edu	37	17	80789199	80789199	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr17:80789199C>T	uc002kga.2	-	2	1443	c.1132G>A	c.(1132-1134)GAA>AAA	p.E378K	TBCD_uc002kfx.1_Intron|TBCD_uc002kfy.1_Intron|TBCD_uc002kfz.2_Intron	NM_024702	NP_078978	Q32MQ0	ZN750_HUMAN	zinc finger protein 750	378						intracellular	zinc ion binding			central_nervous_system(1)	1	Breast(20;0.000523)|all_neural(118;0.0779)	all_cancers(8;0.0514)|all_epithelial(8;0.0748)	OV - Ovarian serous cystadenocarcinoma(97;0.0868)|BRCA - Breast invasive adenocarcinoma(99;0.149)			ATTGGACTTTCGAACTCGACG	0.572		NaN											0	0	0	0.005443	0	22	108									
TBCD	6904	broad.mit.edu	37	17	80887006	80887006	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr17:80887006G>T	uc002kfz.2	+	31	2841	c.2711G>T	c.(2710-2712)TGC>TTC	p.C904F	TBCD_uc002kfy.1_Missense_Mutation_p.C904F|TBCD_uc002kgb.1_Missense_Mutation_p.C229F|TBCD_uc002kgc.2_Missense_Mutation_p.C49F|TBCD_uc002kgd.2_5'Flank	NM_005993	NP_005984	Q9BTW9	TBCD_HUMAN	beta-tubulin cofactor D	904					'de novo' posttranslational protein folding|adherens junction assembly|negative regulation of cell-substrate adhesion|negative regulation of microtubule polymerization|post-chaperonin tubulin folding pathway|tight junction assembly	adherens junction|cytoplasm|lateral plasma membrane|microtubule|tight junction	beta-tubulin binding|chaperone binding|GTPase activator activity				0	Breast(20;0.000523)|all_neural(118;0.0779)	all_cancers(8;0.0266)|all_epithelial(8;0.0696)	OV - Ovarian serous cystadenocarcinoma(97;0.0868)|BRCA - Breast invasive adenocarcinoma(99;0.18)			CGCATCATGTGCTGTGTGGCC	0.612		NaN											1	0	0.00448238	0.004482	0.0047183	7	71									
LAMA3	3909	broad.mit.edu	37	18	21519274	21519274	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr18:21519274C>T	uc002kuq.2	+	68	9036	c.8950C>T	c.(8950-8952)CAT>TAT	p.H2984Y	LAMA3_uc002kur.2_Missense_Mutation_p.H2928Y|LAMA3_uc002kus.3_Missense_Mutation_p.H1375Y|LAMA3_uc002kut.3_Missense_Mutation_p.H1319Y	NM_198129	NP_937762	Q16787	LAMA3_HUMAN	laminin alpha 3 subunit isoform 1	2984					cell adhesion|epidermis development|hemidesmosome assembly|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|skin(2)|central_nervous_system(1)	11	all_cancers(21;7.81e-05)|all_epithelial(16;4.45e-07)|Lung NSC(20;0.00156)|all_lung(20;0.00508)|Colorectal(14;0.0202)|Ovarian(20;0.17)				Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	CCAGGCCAATCATGGAGCCCT	0.547		NaN											0	0	0	0.01441	0	75	196									
RNF126	55658	broad.mit.edu	37	19	648951	648951	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr19:648951C>A	uc010drs.2	-	7	707	c.601G>T	c.(601-603)GGC>TGC	p.G201C	RNF126_uc002lpi.2_Missense_Mutation_p.G25C	NM_194460	NP_919442	Q9BV68	RN126_HUMAN	ring finger protein 126	201							protein binding|zinc ion binding				0		all_epithelial(18;2.78e-22)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;3.55e-06)|all_lung(49;5.41e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GGTGGGGGGCCTGTGTTTTCA	0.552		NaN											1	0	0.000602214	0.014758	0.000642934	4	13									
PCSK4	54760	broad.mit.edu	37	19	1489889	1489889	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr19:1489889G>C	uc002ltb.1	-	2	259	c.197C>G	c.(196-198)CCT>CGT	p.P66R	PCSK4_uc002lta.2_5'UTR|REEP6_uc010xgp.1_5'Flank|REEP6_uc002ltc.2_5'Flank	NM_017573	NP_060043	Q6UW60	PCSK4_HUMAN	proprotein convertase subtilisin/kexin type 4	66				P -> S (in Ref. 1; AAQ89322 and 3; AAH36354).	proteolysis	integral to membrane	serine-type endopeptidase activity				0		Acute lymphoblastic leukemia(61;3.02e-13)|all_hematologic(61;4.32e-09)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CTGCCCGTCAGGGAAGATCTG	0.672		NaN											0	0	0	0.014758	0	3	14									
MBD3	53615	broad.mit.edu	37	19	1584563	1584563	+	Silent	SNP	C	C	T			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr19:1584563C>T	uc002ltl.1	-	3	406	c.384G>A	c.(382-384)CAG>CAA	p.Q128Q	MBD3_uc002ltj.2_Silent_p.Q128Q|MBD3_uc002ltk.2_Silent_p.Q96Q	NM_003926	NP_003917	O95983	MBD3_HUMAN	methyl-CpG binding domain protein 3	128					transcription, DNA-dependent	NuRD complex	DNA binding|protein binding			ovary(1)|pancreas(1)|skin(1)	3		Acute lymphoblastic leukemia(61;3.02e-13)|all_hematologic(61;4.32e-09)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|Lung(535;0.179)|STAD - Stomach adenocarcinoma(1328;0.18)		CCACCGCCTTCTGCGGGTCGC	0.632		NaN											0	0	0	0.004656	0	25	89									
SH3GL1	6455	broad.mit.edu	37	19	4363777	4363777	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr19:4363777C>G	uc002maj.2	-	6	670	c.564G>C	c.(562-564)GAG>GAC	p.E188D	SH3GL1_uc002mak.2_Missense_Mutation_p.E124D|SH3GL1_uc010xig.1_Missense_Mutation_p.E140D	NM_003025	NP_003016	Q99961	SH3G1_HUMAN	SH3-domain GRB2-like 1	188	Potential.|BAR.				central nervous system development|endocytosis|signal transduction	early endosome membrane	lipid binding|protein binding			ovary(2)	2				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0152)|STAD - Stomach adenocarcinoma(1328;0.182)		CCTCGAACTTCTCCAGCGCCT	0.582		NaN	T	MLL	AL								0	0	0	0.012319	0	20	85									
NRTN	4902	broad.mit.edu	37	19	5824095	5824095	+	Translation_Start_Site	SNP	C	C	A			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr19:5824095C>A	uc002mde.2	+	1	278	c.-81C>A	c.(-83--79)TCCTG>TCATG			NM_004558	NP_004549	Q99748	NRTN_HUMAN	neurturin preproprotein						axon guidance|MAPKKK cascade|neural crest cell migration|transmembrane receptor protein tyrosine kinase signaling pathway	extracellular region	growth factor activity				0						ACACTGAGTCCTGGCCCAGCG	0.632		NaN											1	0	0.000602214	0.014758	0.000642934	5	27									
MLLT1	4298	broad.mit.edu	37	19	6230661	6230661	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr19:6230661C>A	uc002mek.2	-	4	504	c.340G>T	c.(340-342)GTG>TTG	p.V114L		NM_005934	NP_005925	Q03111	ENL_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	114					regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|nucleolus	DNA binding|protein binding			skin(1)	1						AGGTGGTTCACGGGCGGGTTG	0.612		NaN	T	MLL	AL								1	0	2.17066e-49	0.01441	2.60479e-49	97	162									
CNN1	1264	broad.mit.edu	37	19	11660204	11660204	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr19:11660204G>A	uc002msc.1	+	6	732	c.568G>A	c.(568-570)GAC>AAC	p.D190N	CNN1_uc010xmb.1_Missense_Mutation_p.D140N|CNN1_uc010xmc.1_Missense_Mutation_p.D140N	NM_001299	NP_001290	P51911	CNN1_HUMAN	calponin 1, basic, smooth muscle	190					actomyosin structure organization|regulation of smooth muscle contraction	cytoskeleton	actin binding|calmodulin binding				0						CCACCTCTACGACCCCAAGCT	0.617		NaN											0	0	0	0.007413	0	16	77									
COMP	1311	broad.mit.edu	37	19	18902016	18902016	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr19:18902016C>A	uc002nke.2	-	1	99	c.63G>T	c.(61-63)CAG>CAT	p.Q21H	COMP_uc002nkd.2_Translation_Start_Site|COMP_uc010xqj.1_Missense_Mutation_p.Q21H	NM_000095	NP_000086	P49747	COMP_HUMAN	cartilage oligomeric matrix protein precursor	21					anti-apoptosis|apoptosis|cell adhesion|limb development	extracellular space|proteinaceous extracellular matrix	calcium ion binding|collagen binding|extracellular matrix structural constituent|heparan sulfate proteoglycan binding|heparin binding				0						GGCTCTGGCCCTGTCCGGACG	0.697		NaN											1	0	7.48243e-07	0.006214	8.28313e-07	9	8									
ZNF737	100129842	broad.mit.edu	37	19	20728275	20728275	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr19:20728275G>A	uc002npa.2	-	4	914	c.734C>T	c.(733-735)ACT>ATT	p.T245I		NM_001159293	NP_001152765	C9JHM3	C9JHM3_HUMAN	zinc finger protein 737	245					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding			ovary(1)	1						CTTATGTGCAGTAAGGTATGA	0.403		NaN											0	0	0	0.004672	0	3	26									
ZNF626	199777	broad.mit.edu	37	19	20828521	20828521	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr19:20828521C>A	uc002npb.1	-	3	345	c.195G>T	c.(193-195)ATG>ATT	p.M65I	ZNF626_uc002npc.1_Intron|ZNF626_uc002npd.1_Missense_Mutation_p.M65I	NM_001076675	NP_001070143	Q68DY1	ZN626_HUMAN	zinc finger protein 626 isoform 1	65	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1						CATTTCTCTTCATGGTCAAAG	0.388		NaN											1	0	0.00024832	0.009096	0.000267011	4	45									
ZNF626	199777	broad.mit.edu	37	19	20829085	20829085	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr19:20829085C>A	uc002npb.1	-	2	280	c.130G>T	c.(130-132)GGT>TGT	p.G44C	ZNF626_uc002npc.1_Intron|ZNF626_uc002npd.1_Missense_Mutation_p.G44C	NM_001076675	NP_001070143	Q68DY1	ZN626_HUMAN	zinc finger protein 626 isoform 1	44	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1						TTATCCTCACCAAGGAAGACC	0.333		NaN											1	0	1.05317e-09	0.020292	1.21054e-09	13	80									
MLL4	9757	broad.mit.edu	37	19	36212397	36212397	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08			G	C	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr19:36212397G>C	uc010eei.2	+	3	2148	c.2148G>C	c.(2146-2148)AAG>AAC	p.K716N		NM_014727	NP_055542	Q9UMN6	MLL4_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 4	716	Pro-rich.				chromatin-mediated maintenance of transcription		DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(6)|breast(2)|ovary(1)|kidney(1)|skin(1)	11	all_lung(56;3.33e-07)|Lung NSC(56;5.02e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			CTCCTGTTAAGGCCGAGGTGT	0.657		NaN											0	0	0	0.00499	0	15	76									
ZNF383	163087	broad.mit.edu	37	19	37733545	37733545	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr19:37733545G>C	uc002oft.1	+	8	987	c.407G>C	c.(406-408)GGG>GCG	p.G136A	ZNF383_uc002ofs.1_Missense_Mutation_p.G71A|ZNF383_uc002ofu.1_Missense_Mutation_p.G136A	NM_152604	NP_689817	Q8NA42	ZN383_HUMAN	zinc finger protein 383	136					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			ovary(1)|skin(1)	2			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			TATCCAAATGGGCATTTTAGT	0.378		NaN											0	0	0	0.008871	0	17	82									
FBXO27	126433	broad.mit.edu	37	19	39521746	39521746	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr19:39521746C>G	uc002okh.2	-	4	577	c.495G>C	c.(493-495)CAG>CAC	p.Q165H		NM_178820	NP_849142	Q8NI29	FBX27_HUMAN	F-box protein 27	165	FBA.				protein catabolic process	SCF ubiquitin ligase complex	glycoprotein binding			ovary(1)	1	all_cancers(60;3.79e-07)|all_lung(34;1.26e-07)|Lung NSC(34;1.46e-07)|all_epithelial(25;4.69e-07)|Ovarian(47;0.0454)		Lung(45;0.000419)|LUSC - Lung squamous cell carcinoma(53;0.000554)			GGTCCAAGACCTGCTTCTTGC	0.527		NaN											0	0	0	0.012213	0	29	144									
HIPK4	147746	broad.mit.edu	37	19	40895437	40895437	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr19:40895437C>T	uc002onp.2	-	1	658	c.373G>A	c.(373-375)GCC>ACC	p.A125T		NM_144685	NP_653286	Q8NE63	HIPK4_HUMAN	homeodomain interacting protein kinase 4	125	Protein kinase.					cytoplasm	ATP binding|protein serine/threonine kinase activity			ovary(1)|stomach(1)	2			Lung(22;4.95e-05)|LUSC - Lung squamous cell carcinoma(20;0.000292)			TTGAGCCGGGCCAGGGCTGTG	0.602		NaN											0	0	0	0.01892	0	19	92									
CYP2A7	1549	broad.mit.edu	37	19	41386396	41386396	+	Silent	SNP	G	G	T			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr19:41386396G>T	uc002opm.2	-	3	1023	c.481C>A	c.(481-483)CGG>AGG	p.R161R	CYP2A7_uc002opo.2_Silent_p.R161R|CYP2A7_uc002opn.2_Silent_p.R110R	NM_000764	NP_000755	P20853	CP2A7_HUMAN	cytochrome P450, family 2, subfamily A,	161						endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding			ovary(1)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	3			LUSC - Lung squamous cell carcinoma(20;0.000219)|Lung(22;0.000959)			TGCGTGCTCCGGATGGCCTCG	0.662		NaN											1	0	1.836e-18	0.017118	2.16851e-18	29	173									
IRGC	56269	broad.mit.edu	37	19	44223733	44223733	+	Silent	SNP	G	G	A			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr19:44223733G>A	uc002oxh.2	+	2	1170	c.1023G>A	c.(1021-1023)GAG>GAA	p.E341E		NM_019612	NP_062558	Q6NXR0	IIGP5_HUMAN	immunity-related GTPase family, cinema	341						membrane	GTP binding|hydrolase activity, acting on acid anhydrides			ovary(1)|central_nervous_system(1)|skin(1)	3		Prostate(69;0.0435)				TCTCGCCTGAGACTGTCCTGC	0.677		NaN											0	0	0	0.010729	0	10	64									
ZNF227	7770	broad.mit.edu	37	19	44739769	44739769	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr19:44739769C>T	uc002oyu.2	+	6	1391	c.1186C>T	c.(1186-1188)CGT>TGT	p.R396C	ZNF227_uc010xwu.1_Missense_Mutation_p.R345C|ZNF227_uc002oyv.2_Missense_Mutation_p.R396C|ZNF227_uc010xwv.1_Missense_Mutation_p.R345C|ZNF227_uc010xww.1_Missense_Mutation_p.R317C|ZNF227_uc002oyw.2_Missense_Mutation_p.R368C|ZNF227_uc010ejh.2_Missense_Mutation_p.R389C|ZNF235_uc002oyx.1_Intron	NM_182490	NP_872296	Q86WZ6	ZN227_HUMAN	zinc finger protein 227	396	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Prostate(69;0.0435)				TGTTAATCTCCGTGTTCACCA	0.463		NaN											0	0	0	0.008871	0	19	39									
ZFP112	7771	broad.mit.edu	37	19	44832239	44832239	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr19:44832239C>G	uc010ejj.2	-	5	2202	c.2089G>C	c.(2089-2091)GAG>CAG	p.E697Q	ZFP112_uc002ozc.3_Missense_Mutation_p.E691Q|ZFP112_uc010xwy.1_Missense_Mutation_p.E714Q|ZFP112_uc010xwz.1_Missense_Mutation_p.E696Q	NM_001083335	NP_001076804	Q9UJU3	ZF112_HUMAN	zinc finger protein 228 isoform 1	697	C2H2-type 11.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)|skin(2)	5						TTACCACACTCATCACATTGG	0.448		NaN											0	0	0	0.00308	0	8	41									
FBXO46	23403	broad.mit.edu	37	19	46216736	46216736	+	Silent	SNP	G	G	A			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr19:46216736G>A	uc002pcy.2	-	2	143	c.18C>T	c.(16-18)CTC>CTT	p.L6L	FBXO46_uc002pcz.2_Silent_p.L6L	NM_001080469	NP_001073938	Q6PJ61	FBX46_HUMAN	F-box protein 46	6							protein binding			ovary(1)|lung(1)|breast(1)	3		Ovarian(192;0.179)|all_neural(266;0.224)		OV - Ovarian serous cystadenocarcinoma(262;0.00568)|GBM - Glioblastoma multiforme(486;0.0844)|Epithelial(262;0.201)		GGAAGGGCAGGAGGCTCCCAC	0.657		NaN											0	0	0	0.001168	0	5	68									
CCDC8	83987	broad.mit.edu	37	19	46914959	46914959	+	Missense_Mutation	SNP	T	T	C			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr19:46914959T>C	uc002pep.2	-	1	1961	c.1109A>G	c.(1108-1110)GAG>GGG	p.E370G		NM_032040	NP_114429	Q9H0W5	CCDC8_HUMAN	coiled-coil domain containing 8	370						plasma membrane				ovary(3)	3				OV - Ovarian serous cystadenocarcinoma(262;4.66e-05)|all cancers(93;0.000582)|Epithelial(262;0.00428)|GBM - Glioblastoma multiforme(486;0.0421)		AGCTGGGGCCTCTGCCCTCTG	0.607		NaN											0	0	0	0.004482	0	5	227									
DHX34	9704	broad.mit.edu	37	19	47865903	47865903	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr19:47865903C>G	uc010xyn.1	+	6	1887	c.1546C>G	c.(1546-1548)CCC>GCC	p.P516A	DHX34_uc010elc.1_Missense_Mutation_p.P431A	NM_014681	NP_055496	Q14147	DHX34_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 34	516	Helicase C-terminal.					intracellular	ATP binding|ATP-dependent helicase activity|RNA binding|zinc ion binding			ovary(4)|upper_aerodigestive_tract(1)	5		all_cancers(25;1.65e-09)|all_epithelial(76;9.95e-08)|all_lung(116;7.27e-07)|Lung NSC(112;1.6e-06)|Ovarian(192;0.0139)|all_neural(266;0.026)|Breast(70;0.0503)		all cancers(93;7.16e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.000489)|GBM - Glioblastoma multiforme(486;0.00413)|Epithelial(262;0.0132)		CGCCCCCTACCCCGTCCCAGA	0.652		NaN											0	0	0	0.003163	0	12	40									
AP2A1	160	broad.mit.edu	37	19	50302585	50302585	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr19:50302585G>C	uc002ppn.2	+	9	1178	c.967G>C	c.(967-969)GAG>CAG	p.E323Q	AP2A1_uc010enj.1_RNA|AP2A1_uc002ppo.2_Missense_Mutation_p.E323Q|AP2A1_uc002ppp.1_5'Flank	NM_014203	NP_055018	O95782	AP2A1_HUMAN	adaptor-related protein complex 2, alpha 1	323					axon guidance|endocytosis|epidermal growth factor receptor signaling pathway|Golgi to endosome transport|intracellular protein transport|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|regulation of defense response to virus by virus|synaptic transmission|viral reproduction	AP-2 adaptor complex|clathrin coat of trans-Golgi network vesicle|cytosol	protein binding|protein transporter activity			ovary(2)	2		all_lung(116;3.24e-07)|Lung NSC(112;1.6e-06)|all_neural(266;0.0459)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.0023)|GBM - Glioblastoma multiforme(134;0.0157)		TGCTGGCAGTGAGCCCAACCT	0.637		NaN											0	0	0	0.020292	0	11	31									
LILRA2	11027	broad.mit.edu	37	19	55086317	55086318	+	Nonsense_Mutation	DNP	GG	GG	TA			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr19:55086317_55086318GG>TA	uc002qgg.3	+	4	561_562	c.472_473GG>TA	c.(472-474)GGA>TAA	p.G158*	LILRA2_uc010ern.2_Nonsense_Mutation_p.G158*|LILRA2_uc002qgf.2_Nonsense_Mutation_p.G158*|LILRA2_uc010yfe.1_Nonsense_Mutation_p.G158*|LILRA2_uc010yff.1_Nonsense_Mutation_p.G146*|LILRA2_uc010ero.2_Nonsense_Mutation_p.G146*|LILRA2_uc010yfg.1_Nonsense_Mutation_p.G158*	NM_001130917	NP_001124389	Q8N149	LIRA2_HUMAN	leukocyte immunoglobulin-like receptor,	158	Extracellular (Potential).|Ig-like C2-type 2.				defense response	integral to membrane	antigen binding|receptor activity			ovary(1)	1				GBM - Glioblastoma multiforme(193;0.0963)		GTGTAAGGAAGGAGAAGATGAA	0.604		NaN											0	0	0	0.004672	0	24	162									
LILRA1	11024	broad.mit.edu	37	19	55106715	55106715	+	Nonsense_Mutation	SNP	C	C	G			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr19:55106715C>G	uc002qgh.1	+	5	691	c.509C>G	c.(508-510)TCA>TGA	p.S170*	LILRA2_uc010yfg.1_Intron|LILRA1_uc010yfh.1_Nonsense_Mutation_p.S170*	NM_006863	NP_006854	O75019	LIRA1_HUMAN	leukocyte immunoglobulin-like receptor,	170	Ig-like C2-type 2.|Extracellular (Potential).				cell surface receptor linked signaling pathway|defense response|regulation of immune response	integral to membrane|plasma membrane	antigen binding|transmembrane receptor activity			skin(2)|ovary(1)	3				GBM - Glioblastoma multiforme(193;0.0348)		TGCCTGAACTCACAGCCCCGT	0.567		NaN											0	0	0	0.00874	0	36	208									
KIR3DL1	3811	broad.mit.edu	37	19	55341573	55341573	+	Missense_Mutation	SNP	C	C	G	rs1130473		TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr19:55341573C>G	uc002qhk.3	+	9	1241	c.1178C>G	c.(1177-1179)CCT>CGT	p.P393R	KIR2DS4_uc010yfj.1_Intron|KIR2DS4_uc010yfk.1_Intron|KIR3DL1_uc010yfn.1_Missense_Mutation_p.P318R|KIR3DL1_uc010esf.2_Missense_Mutation_p.P298R|KIR3DL1_uc010yfo.1_Missense_Mutation_p.P335R|KIR3DL1_uc002qhl.3_Intron|KIR2DS4_uc010esg.1_5'Flank|KIR2DS4_uc002qhm.1_5'Flank	NM_013289	NP_037421	P43629	KI3L1_HUMAN	killer cell immunoglobulin-like receptor, three	393	Cytoplasmic (Potential).				immune response|regulation of immune response	integral to plasma membrane	HLA-B specific inhibitory MHC class I receptor activity			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|skin(1)	5				GBM - Glioblastoma multiforme(193;0.0192)		GAACAAGACCCTGAGGAGGTG	0.522		NaN											0	0	0	0.01441	0	85	410									
TNNT1	7138	broad.mit.edu	37	19	55653248	55653248	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr19:55653248C>G	uc002qjb.3	-	7	258	c.169G>C	c.(169-171)GAA>CAA	p.E57Q	TNNT1_uc002qiz.3_5'UTR|TNNT1_uc002qja.3_5'UTR|TNNT1_uc002qjc.3_Missense_Mutation_p.E57Q|TNNT1_uc002qje.3_Missense_Mutation_p.E46Q|TNNT1_uc002qjd.3_Missense_Mutation_p.E46Q|TNNT1_uc002qjf.2_Missense_Mutation_p.E53Q	NM_003283	NP_003274	P13805	TNNT1_HUMAN	troponin T1, skeletal, slow isoform a	57					muscle filament sliding|negative regulation of muscle contraction	cytosol|troponin complex	tropomyosin binding			ovary(1)	1			BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.047)		CGCTCCCCTTCTGGGATCTTT	0.448		NaN											0	0	0	0.011902	0	35	212									
SH3YL1	26751	broad.mit.edu	37	2	234213	234213	+	Silent	SNP	G	G	C			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr2:234213G>C	uc002qvx.2	-	5	435	c.351C>G	c.(349-351)GGC>GGG	p.G117G	SH3YL1_uc002qvy.2_Silent_p.G117G|SH3YL1_uc002qvz.2_RNA|SH3YL1_uc002qwa.2_RNA|SH3YL1_uc010ewe.2_Silent_p.G21G|SH3YL1_uc002qvu.2_RNA|SH3YL1_uc002qvv.2_Silent_p.G21G|SH3YL1_uc002qvw.2_RNA	NM_015677	NP_056492	Q96HL8	SH3Y1_HUMAN	SH3 domain containing, Ysc84-like 1 isoform 1	117										ovary(1)	1	all_hematologic(175;0.0429)|Acute lymphoblastic leukemia(172;0.0627)	all_cancers(51;0.034)		all cancers(51;0.000647)|Epithelial(75;0.0043)|OV - Ovarian serous cystadenocarcinoma(76;0.00871)|GBM - Glioblastoma multiforme(21;0.148)		TCAGATTTCCGCCTTTTGCAA	0.418		NaN											0	0	0	0.007413	0	15	118									
KLF11	8462	broad.mit.edu	37	2	10186443	10186443	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr2:10186443G>T	uc002raf.1	+	2	371	c.209G>T	c.(208-210)AGA>ATA	p.R70I	KLF11_uc010yjc.1_Missense_Mutation_p.R53I	NM_003597	NP_003588	O14901	KLF11_HUMAN	Kruppel-like factor 11	70					apoptosis|negative regulation of cell proliferation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of apoptosis|regulation of transcription involved in S phase of mitotic cell cycle	nucleus	sequence-specific DNA binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(2)	2	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.133)|OV - Ovarian serous cystadenocarcinoma(76;0.228)		TTGCGGATAAGACCCCTCACG	0.512		NaN											1	0	7.03913e-09	0.013537	7.96882e-09	10	45									
FAM49A	81553	broad.mit.edu	37	2	16747025	16747025	+	Silent	SNP	A	A	G			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr2:16747025A>G	uc010exm.1	-	3	229	c.81T>C	c.(79-81)CCT>CCC	p.P27P	FAM49A_uc002rck.1_Silent_p.P27P	NM_030797	NP_110424	Q9H0Q0	FA49A_HUMAN	family with sequence similarity 49, member A	27						intracellular					0	Acute lymphoblastic leukemia(172;0.0734)|all_hematologic(175;0.088)		GBM - Glioblastoma multiforme(3;0.00969)			CTCCTTCTGTAGGCTGAGCAT	0.498		NaN											0	0	0	0.004672	0	3	29									
C2orf16	84226	broad.mit.edu	37	2	27800283	27800283	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr2:27800283G>A	uc002rkz.3	+	1	895	c.844G>A	c.(844-846)GAG>AAG	p.E282K		NM_032266	NP_115642	Q68DN1	CB016_HUMAN	hypothetical protein LOC84226	282										large_intestine(1)	1	Acute lymphoblastic leukemia(172;0.155)					GTTGACCGCTGAGGCAAGGAT	0.463		NaN											0	0	0	0.021523	0	26	54									
VIT	5212	broad.mit.edu	37	2	37035743	37035743	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr2:37035743G>C	uc002rpl.2	+	15	1739	c.1518G>C	c.(1516-1518)TTG>TTC	p.L506F	VIT_uc002rpm.2_Missense_Mutation_p.L484F|VIT_uc010ezv.2_Missense_Mutation_p.L462F|VIT_uc010ezw.2_Missense_Mutation_p.L463F	NM_053276	NP_444506	Q6UXI7	VITRN_HUMAN	vitrin	491						proteinaceous extracellular matrix				ovary(1)|pancreas(1)	2		all_hematologic(82;0.248)				AGACCTGCTTGAACTCGGCTG	0.612		NaN											0	0	0	0.021523	0	20	136									
SPTBN1	6711	broad.mit.edu	37	2	54883083	54883084	+	Missense_Mutation	DNP	GA	GA	TT			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr2:54883083_54883084GA>TT	uc002rxu.2	+	29	6243_6244	c.5994_5995GA>TT	c.(5992-5997)AAGAGG>AATTGG	p.1998_1999KR>NW	SPTBN1_uc002rxx.2_Missense_Mutation_p.1985_1986KR>NW|SPTBN1_uc002rxy.2_Missense_Mutation_p.143_144KR>NW|SPTBN1_uc010you.1_5'Flank	NM_003128	NP_003119	Q01082	SPTB2_HUMAN	spectrin, beta, non-erythrocytic 1 isoform 1	1998_1999	Spectrin 17.|Interaction with ANK2.				actin filament capping|axon guidance	cytosol|nucleolus|plasma membrane|sarcomere|spectrin	actin binding|calmodulin binding|protein binding|structural constituent of cytoskeleton			ovary(3)|breast(2)|central_nervous_system(2)|skin(1)	8			Lung(47;0.24)			TGACGGAAAAGAGGAAAGAAAT	0.411		NaN											0	0	0	0.004672	0	5	38									
ZAP70	7535	broad.mit.edu	37	2	98340715	98340715	+	Silent	SNP	C	C	T			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr2:98340715C>T	uc002syd.1	+	3	423	c.216C>T	c.(214-216)GCC>GCT	p.A72A	ZAP70_uc010yvf.1_Silent_p.A72A|ZAP70_uc002sye.1_5'Flank	NM_001079	NP_001070	P43403	ZAP70_HUMAN	zeta-chain associated protein kinase 70kDa	72	SH2 1.				immune response|intracellular protein kinase cascade|positive thymic T cell selection|T cell receptor signaling pathway	cytosol|T cell receptor complex	ATP binding|non-membrane spanning protein tyrosine kinase activity			lung(4)|upper_aerodigestive_tract(1)|ovary(1)	6						ACGCCATTGCCGGCGGCAAAG	0.677		NaN											0	0	0	0.004672	0	3	34									
EIF5B	9669	broad.mit.edu	37	2	99993068	99993068	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr2:99993068G>C	uc002tab.2	+	10	1995	c.1811G>C	c.(1810-1812)AGG>ACG	p.R604T		NM_015904	NP_056988	O60841	IF2P_HUMAN	eukaryotic translation initiation factor 5B	604					regulation of translational initiation	cytosol	GTP binding|GTPase activity|protein binding|translation initiation factor activity			ovary(2)|pancreas(1)	3						AAAGAAGAAAGGGCTTATGAC	0.373		NaN											0	0	0	0.016723	0	10	41									
MERTK	10461	broad.mit.edu	37	2	112779916	112779916	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr2:112779916G>A	uc002thk.1	+	18	2553	c.2431G>A	c.(2431-2433)GAC>AAC	p.D811N	MERTK_uc002thl.1_Missense_Mutation_p.D635N	NM_006343	NP_006334	Q12866	MERTK_HUMAN	MER receptor tyrosine kinase precursor	811	Protein kinase.|Cytoplasmic (Potential).				cell surface receptor linked signaling pathway|cell-cell signaling|leukocyte migration	integral to plasma membrane|soluble fraction	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(6)|upper_aerodigestive_tract(1)|stomach(1)|kidney(1)	9						TGAGATGTATGACTATCTTCT	0.537		NaN											0	0	0	0.00499	0	17	47									
CBWD2	150472	broad.mit.edu	37	2	114195539	114195539	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr2:114195539G>C	uc002tju.2	+	1	272	c.94G>C	c.(94-96)GAG>CAG	p.E32Q	CBWD2_uc002tjt.2_Missense_Mutation_p.E32Q|CBWD2_uc010yxw.1_5'UTR|CBWD2_uc002tjv.2_5'UTR|CBWD2_uc010fkv.2_RNA	NM_172003	NP_742000	Q8IUF1	CBWD2_HUMAN	COBW domain-containing protein 2	32	Poly-Glu.						ATP binding|protein binding				0						GCAAAGCGAGGAGGAGGAAAA	0.547		NaN											0	0	0	0.001168	0	5	205									
SP110	3431	broad.mit.edu	37	2	231081529	231081529	+	Silent	SNP	T	T	C			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr2:231081529T>C	uc002vqh.3	-	2	354	c.114A>G	c.(112-114)CTA>CTG	p.L38L	SP110_uc002vqg.3_Silent_p.L38L|SP110_uc002vqi.3_Silent_p.L38L|SP110_uc010fxk.2_Silent_p.L38L	NM_004509	NP_004500	Q9HB58	SP110_HUMAN	SP110 nuclear body protein isoform a	38	HSR.				interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|signal transducer activity|zinc ion binding			ovary(2)|breast(2)	4		Renal(207;0.0112)|all_lung(227;0.0223)|Lung NSC(271;0.0983)|all_hematologic(139;0.104)|Acute lymphoblastic leukemia(138;0.169)		Epithelial(121;2.61e-12)|all cancers(144;6.39e-10)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.0097)		TGGAGTTGTCTAGGAGGCCTT	0.483		NaN											0	0	0	0.010504	0	18	70									
UGT1A9	54600	broad.mit.edu	37	2	234581244	234581244	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr2:234581244C>T	uc002vus.2	+	1	701	c.664C>T	c.(664-666)CGT>TGT	p.R222C	UGT1A8_uc010zmv.1_Intron|UGT1A8_uc002vup.2_Intron|UGT1A10_uc002vuq.3_Intron|UGT1A10_uc002vur.2_Intron|UGT1A9_uc010zmw.1_Missense_Mutation_p.R222C	NM_021027	NP_066307	O60656	UD19_HUMAN	UDP glycosyltransferase 1 family, polypeptide A9	222					drug metabolic process|flavone metabolic process|negative regulation of fatty acid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	enzyme binding|enzyme inhibitor activity|glucuronosyltransferase activity|protein heterodimerization activity|protein homodimerization activity|retinoic acid binding			ovary(3)|breast(1)|skin(1)	5		Breast(86;0.000766)|all_lung(227;0.00269)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0331)|Lung NSC(271;0.0459)|Lung SC(224;0.128)		Epithelial(121;1.26e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000436)|Lung(119;0.00347)|LUSC - Lung squamous cell carcinoma(224;0.00757)	Entacapone(DB00494)|Etodolac(DB00749)|Indomethacin(DB00328)|Irinotecan(DB00762)|Mycophenolic acid(DB01024)|Oxyphenonium(DB00219)|Propofol(DB00818)|Sorafenib(DB00398)	ATTATGCCACCGTTTTTTCAA	0.428		NaN											0	0	0	0.01441	0	52	132									
UGT1A6	54578	broad.mit.edu	37	2	234602440	234602440	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr2:234602440C>T	uc002vuv.3	+	1	929	c.790C>T	c.(790-792)CCT>TCT	p.P264S	UGT1A8_uc010zmv.1_Intron|UGT1A8_uc002vup.2_Intron|UGT1A10_uc002vuq.3_Intron|UGT1A10_uc002vur.2_Intron|UGT1A9_uc010zmw.1_Intron|UGT1A9_uc002vus.2_Intron|UGT1A7_uc010zmx.1_Intron|UGT1A7_uc002vut.2_Intron|UGT1A6_uc002vuu.2_Intron|UGT1A6_uc010zmy.1_Missense_Mutation_p.P264S	NM_001072	NP_001063	P19224	UD16_HUMAN	UDP glycosyltransferase 1 family, polypeptide A6	264					xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	enzyme binding|glucuronosyltransferase activity|protein heterodimerization activity|protein homodimerization activity				0		Breast(86;0.000765)|all_lung(227;0.00267)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0328)|Lung NSC(271;0.0457)|Lung SC(224;0.128)		Epithelial(121;5.86e-18)|BRCA - Breast invasive adenocarcinoma(100;0.000384)|Lung(119;0.00306)|LUSC - Lung squamous cell carcinoma(224;0.00702)		GCTTGAATATCCTAGGCCGGT	0.433		NaN											0	0	0	0.01441	0	87	256									
HJURP	55355	broad.mit.edu	37	2	234761219	234761219	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr2:234761219C>T	uc002vvg.2	-	3	298	c.232G>A	c.(232-234)GAG>AAG	p.E78K	HJURP_uc010znd.1_Missense_Mutation_p.E71K|HJURP_uc010zne.1_Missense_Mutation_p.E71K	NM_018410	NP_060880	Q8NCD3	HJURP_HUMAN	Holliday junction recognition protein	78					cell cycle|CenH3-containing nucleosome assembly at centromere|centromeric core chromatin assembly|chromosome segregation|regulation of DNA binding|regulation of protein complex assembly	condensed chromosome kinetochore|cytoplasm|nucleolus|nucleoplasm	DNA binding|histone binding			ovary(1)	1		Breast(86;0.00204)|all_lung(227;0.00433)|Renal(207;0.00685)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0326)|Lung NSC(271;0.0719)|Lung SC(224;0.128)		Epithelial(121;2.01e-18)|BRCA - Breast invasive adenocarcinoma(100;0.000186)|Lung(119;0.00521)|LUSC - Lung squamous cell carcinoma(224;0.00829)		ACCTGGATCTCTCCTTCGTTT	0.378		NaN											0	0	0	0.014758	0	5	15									
ZCCHC3	85364	broad.mit.edu	37	20	278815	278815	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr20:278815G>C	uc002wdf.2	+	2	609	c.585G>C	c.(583-585)ATG>ATC	p.M195I	ZCCHC3_uc002wdg.2_Intron	NM_033089	NP_149080	Q9NUD5	ZCHC3_HUMAN	zinc finger, CCHC domain containing 3	196							nucleic acid binding|zinc ion binding				0		all_cancers(10;0.000209)|Lung NSC(37;0.0417)|all_lung(30;0.0713)|all_epithelial(17;0.0748)|Breast(17;0.231)	OV - Ovarian serous cystadenocarcinoma(29;0.149)			CCATCGGCATGGACCCGAGCG	0.647		NaN											0	0	0	0.004482	0	7	43									
MAVS	57506	broad.mit.edu	37	20	3846784	3846784	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr20:3846784G>A	uc002wjw.3	+	7	1782	c.1613G>A	c.(1612-1614)CGT>CAT	p.R538H	MAVS_uc002wjx.3_Missense_Mutation_p.R397H|MAVS_uc002wjy.3_Missense_Mutation_p.R236H	NM_020746	NP_065797	Q7Z434	MAVS_HUMAN	virus-induced signaling adapter	538	Mitochondrial intermembrane (Probable).				activation of innate immune response|cellular response to exogenous dsRNA|defense response to bacterium|innate immune response|interspecies interaction between organisms|negative regulation of type I interferon production|positive regulation of chemokine (C-C motif) ligand 5 production|positive regulation of defense response to virus by host|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of interleukin-8 production|positive regulation of IP-10 production|positive regulation of protein import into nucleus, translocation|positive regulation of protein phosphorylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription factor import into nucleus|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|positive regulation of type I interferon-mediated signaling pathway|response to virus	integral to membrane|mitochondrial outer membrane	CARD domain binding|protein kinase binding|signal transducer activity				0						TACCGGCGGCGTCTGCACTAG	0.637		NaN											0	0	0	0.013537	0	9	48									
SPTLC3	55304	broad.mit.edu	37	20	13074186	13074186	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr20:13074186G>T	uc002wod.1	+	6	1077	c.788G>T	c.(787-789)CGA>CTA	p.R263L		NM_018327	NP_060797	Q9NUV7	SPTC3_HUMAN	serine palmitoyltransferase, long chain base	263					sphingoid biosynthetic process	integral to membrane|serine C-palmitoyltransferase complex	pyridoxal phosphate binding|serine C-palmitoyltransferase activity|transferase activity, transferring nitrogenous groups				0					Pyridoxal Phosphate(DB00114)	CTTGGGGCCCGACTCTCAGGT	0.398		NaN											1	0	1.26484e-09	0.00308	1.4483e-09	6	77									
E2F1	1869	broad.mit.edu	37	20	32264765	32264765	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr20:32264765C>G	uc002wzu.3	-	7	1227	c.1087G>C	c.(1087-1089)GGC>CGC	p.G363R	NECAB3_uc002wzm.3_5'Flank|NECAB3_uc002wzn.3_5'Flank|NECAB3_uc002wzo.3_5'Flank|NECAB3_uc002wzp.3_5'Flank|NECAB3_uc002wzq.3_5'Flank|NECAB3_uc002wzr.3_5'Flank|NECAB3_uc010geo.2_5'Flank	NM_005225	NP_005216	Q01094	E2F1_HUMAN	E2F transcription factor 1	363	Required for interaction with TRIM28.				apoptosis|cell proliferation|G1 phase of mitotic cell cycle|G2 phase of mitotic cell cycle|mRNA stabilization|negative regulation of transcription involved in G1/S phase of mitotic cell cycle|positive regulation of fibroblast proliferation|positive regulation of transcription from RNA polymerase II promoter|regulation of G1/S transition of mitotic cell cycle	mitochondrion|Rb-E2F complex	sequence-specific DNA binding transcription factor activity|transcription corepressor activity|transcription factor binding				0						CGCAGGCTGCCCATCCGGGAC	0.726		NaN											0	0	0	0.00308	0	5	18									
DLGAP4	22839	broad.mit.edu	37	20	35068239	35068239	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr20:35068239G>A	uc002xff.2	+	5	1759	c.1324G>A	c.(1324-1326)GAC>AAC	p.D442N	DLGAP4_uc010zvp.1_Missense_Mutation_p.D442N	NM_014902	NP_055717	Q9Y2H0	DLGP4_HUMAN	disks large-associated protein 4 isoform a	442					cell-cell signaling	membrane	protein binding			skin(2)|ovary(1)	3	Breast(12;0.0192)	Myeloproliferative disorder(115;0.00878)				CCCCGTCAGCGACAGCCTCAA	0.632		NaN									OREG0025903	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.004007	0	14	53									
DSN1	79980	broad.mit.edu	37	20	35383166	35383166	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr20:35383166C>G	uc010gfr.2	-	10	1334	c.961G>C	c.(961-963)GGA>CGA	p.G321R	DSN1_uc002xfz.2_Missense_Mutation_p.G321R|DSN1_uc002xfy.3_Missense_Mutation_p.G111R|DSN1_uc002xga.2_Missense_Mutation_p.G321R|DSN1_uc010zvs.1_Missense_Mutation_p.G214R|DSN1_uc002xgc.2_Missense_Mutation_p.G305R|DSN1_uc002xgb.2_Missense_Mutation_p.G305R	NM_001145316	NP_001138788	Q9H410	DSN1_HUMAN	DSN1, MIND kinetochore complex component,	321					cell division|chromosome segregation|mitotic prometaphase	cytosol|MIS12/MIND type complex|nucleus	protein binding			ovary(2)	2		Myeloproliferative disorder(115;0.00874)				ACAAGCTTACCGAGCTGTACT	0.473		NaN											0	0	0	0.014758	0	5	35									
RPN2	6185	broad.mit.edu	37	20	35865107	35865107	+	Silent	SNP	C	C	G			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr20:35865107C>G	uc002xgp.2	+	16	2182	c.1878C>G	c.(1876-1878)GTC>GTG	p.V626V	RPN2_uc002xgq.2_Silent_p.V594V	NM_002951	NP_002942	P04844	RPN2_HUMAN	ribophorin II isoform 1 precursor	626	Cytoplasmic (Potential).				post-translational protein modification|protein N-linked glycosylation via asparagine	integral to membrane|nucleus|oligosaccharyltransferase complex	dolichyl-diphosphooligosaccharide-protein glycotransferase activity|protein binding			ovary(2)|skin(1)	3		Myeloproliferative disorder(115;0.00878)				AGCAGGCAGTCAAGAGGTAAG	0.532		NaN											0	0	0	0.020292	0	12	85									
VSTM2L	128434	broad.mit.edu	37	20	36572409	36572409	+	Silent	SNP	C	C	T			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr20:36572409C>T	uc002xhk.3	+	4	623	c.369C>T	c.(367-369)ATC>ATT	p.I123I		NM_080607	NP_542174	Q96N03	VTM2L_HUMAN	V-set and transmembrane domain containing 2 like	123	Ig-like.									ovary(1)|central_nervous_system(1)	2		Myeloproliferative disorder(115;0.00878)				GCAGCAACATCTCCCACAAGC	0.652		NaN											0	0	0	0.001984	0	5	42									
ZNFX1	57169	broad.mit.edu	37	20	47866170	47866170	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr20:47866170G>T	uc002xui.2	-	14	3638	c.3391C>A	c.(3391-3393)CAG>AAG	p.Q1131K		NM_021035	NP_066363	Q9P2E3	ZNFX1_HUMAN	zinc finger, NFX1-type containing 1	1131							metal ion binding			ovary(2)	2			BRCA - Breast invasive adenocarcinoma(12;0.00173)|COAD - Colon adenocarcinoma(4;0.14)|Colorectal(8;0.166)			GCCTCATGCTGGTTCTGATGG	0.493		NaN											1	0	2.56e-06	0.009096	2.81319e-06	4	125									
PHACTR3	116154	broad.mit.edu	37	20	58322813	58322813	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr20:58322813C>T	uc002yau.2	+	3	748	c.281C>T	c.(280-282)GCG>GTG	p.A94V	PHACTR3_uc002yat.2_Missense_Mutation_p.A91V|PHACTR3_uc010zzw.1_Missense_Mutation_p.A53V|PHACTR3_uc002yav.2_Missense_Mutation_p.A53V|PHACTR3_uc002yaw.2_Missense_Mutation_p.A53V|PHACTR3_uc002yax.2_Missense_Mutation_p.A53V	NM_080672	NP_542403	Q96KR7	PHAR3_HUMAN	phosphatase and actin regulator 3 isoform 1	94	RPEL 1.					nuclear matrix	actin binding|protein phosphatase inhibitor activity			ovary(2)|pancreas(1)	3	all_lung(29;0.00344)		BRCA - Breast invasive adenocarcinoma(7;2.76e-09)			TGTTGGGCAGCGCTGGAGAAG	0.577		NaN											0	0	0	0.010818	0	30	119									
DIDO1	11083	broad.mit.edu	37	20	61513532	61513532	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr20:61513532C>A	uc002ydr.1	-	16	4040	c.3776G>T	c.(3775-3777)GGG>GTG	p.G1259V	DIDO1_uc002yds.1_Missense_Mutation_p.G1259V	NM_033081	NP_149072	Q9BTC0	DIDO1_HUMAN	death inducer-obliterator 1 isoform c	1259	Pro-rich.				apoptosis|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			ovary(3)|skin(3)	6	Breast(26;5.68e-08)					CGGCGGCGACCCAGGAGGTGT	0.622		NaN											1	0	3.13743e-37	0.01441	3.74992e-37	66	262									
KRTAP19-1	337882	broad.mit.edu	37	21	31852400	31852400	+	Silent	SNP	C	C	T			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr21:31852400C>T	uc011acx.1	-	1	237	c.237G>A	c.(235-237)TCG>TCA	p.S79S		NM_181607	NP_853638	Q8IUB9	KR191_HUMAN	keratin associated protein 19-1	79	26 X 2 AA repeats of G-[YCGS].					intermediate filament					0						CTCCATTGTACGATGGGCGGC	0.493		NaN											0	0	0	0.017118	0	30	258									
DNAJC28	54943	broad.mit.edu	37	21	34861116	34861116	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr21:34861116C>A	uc002yrv.2	-	2	1034	c.585G>T	c.(583-585)AAG>AAT	p.K195N	DNAJC28_uc002yrw.2_Missense_Mutation_p.K195N	NM_017833	NP_060303	Q9NX36	DJC28_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 28	195							heat shock protein binding				0						CTTGCGTTATCTTTTGCTGTT	0.373		NaN											1	0	1.67942e-08	0.006122	1.88698e-08	17	59									
SETD4	54093	broad.mit.edu	37	21	37408469	37408469	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr21:37408469C>G	uc002yuw.1	-	10	2642	c.1269G>C	c.(1267-1269)AAG>AAC	p.K423N	SETD4_uc002yux.1_Missense_Mutation_p.K399N|SETD4_uc002yuu.2_RNA|SETD4_uc002yuv.2_Missense_Mutation_p.K423N	NM_017438	NP_059134	Q9NVD3	SETD4_HUMAN	SET domain containing 4 isoform a	423				EILVKYLPSTDKQMDKKISILKDHGYIENLTFGWDGPSWRL LTALKLLCLEAEKFTCWKKVLLGEVISDTNEKTSLDIAQKI CYYFIEETNAVLQKVSHMKDEKEALINQLTLVESLWTEELK ILRASAETLHSLQTAFT -> GWNQLCS (in Ref. 5; AAH02898).						large_intestine(1)|ovary(1)	2						CCCTGAGAATCTTTAGCTCTT	0.443		NaN											0	0	0	0.01441	0	38	132									
UBASH3A	53347	broad.mit.edu	37	21	43854960	43854960	+	Missense_Mutation	SNP	A	A	T			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr21:43854960A>T	uc002zbe.2	+	10	1325	c.1289A>T	c.(1288-1290)GAC>GTC	p.D430V	UBASH3A_uc002zbf.2_Missense_Mutation_p.D392V|UBASH3A_uc010gpc.2_RNA|UBASH3A_uc010gpd.2_RNA|UBASH3A_uc010gpe.2_Missense_Mutation_p.D392V	NM_018961	NP_061834	P57075	UBS3A_HUMAN	ubiquitin associated and SH3 domain containing,	430	Phosphatase-like.					cytosol|nucleus				ovary(3)	3						TACAGGCCAGACCTGAATTTC	0.443		NaN											0	0	0	0.00499	0	14	39									
KRTAP10-7	386675	broad.mit.edu	37	21	46021232	46021232	+	Silent	SNP	C	C	G			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr21:46021232C>G	uc002zfn.3	+	2	721	c.696C>G	c.(694-696)GTC>GTG	p.V232V	C21orf29_uc002zfe.1_Intron|C21orf29_uc010gpv.1_Intron	NM_198689	NP_941962	P60409	KR107_HUMAN	keratin associated protein 10-7	237	30 X 5 AA repeats of C-C-X(3).|17.					keratin filament					0						GTGTGCCTGTCTGCTGCAAGC	0.652		NaN											0	0	0	0.01441	0	34	345									
PCNT	5116	broad.mit.edu	37	21	47847581	47847581	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr21:47847581G>A	uc002zji.3	+	34	7473	c.7366G>A	c.(7366-7368)GTT>ATT	p.V2456I	PCNT_uc002zjj.2_Missense_Mutation_p.V2338I	NM_006031	NP_006022	O95613	PCNT_HUMAN	pericentrin	2456					cilium assembly|G2/M transition of mitotic cell cycle	cytosol|microtubule	calmodulin binding			ovary(4)|breast(2)|pancreas(2)	8	Breast(49;0.112)					CCTTCTGCAGGTTGTGCAAGA	0.577		NaN											0	0	0	0.008871	0	19	86									
DGCR8	54487	broad.mit.edu	37	22	20074017	20074017	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr22:20074017G>C	uc002zri.2	+	2	881	c.531G>C	c.(529-531)GAG>GAC	p.E177D	DGCR8_uc010grz.2_Missense_Mutation_p.E177D|DGCR8_uc002zrj.2_5'Flank	NM_022720	NP_073557	Q8WYQ5	DGCR8_HUMAN	DiGeorge syndrome critical region gene 8	177	Necessary for nuclear localization and retention.|Necessary for interaction with NCL.				primary miRNA processing	cytoplasm|cytoplasm|microtubule cytoskeleton|nucleolus|nucleoplasm	double-stranded RNA binding|metal ion binding|protein binding				0	Colorectal(54;0.0993)					TAGGGGGTGAGAGTGCTGATA	0.537		NaN											0	0	0	0.01441	0	68	471									
TOM1	10043	broad.mit.edu	37	22	35719129	35719129	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr22:35719129C>A	uc003ann.2	+	4	450	c.325C>A	c.(325-327)CCA>ACA	p.P109T	TOM1_uc011ami.1_Missense_Mutation_p.P76T|TOM1_uc011amj.1_5'UTR|TOM1_uc003ans.2_5'UTR|TOM1_uc011amk.1_Missense_Mutation_p.P71T|TOM1_uc003anp.2_Missense_Mutation_p.P109T|TOM1_uc011aml.1_Missense_Mutation_p.P109T|TOM1_uc003ano.2_RNA|TOM1_uc003anq.2_Missense_Mutation_p.P103T|TOM1_uc003anr.2_5'UTR	NM_005488	NP_005479	O60784	TOM1_HUMAN	target of myb1 isoform 1	109	VHS.				endocytosis|endosome transport|intracellular protein transport	cytosol|early endosome|membrane	protein binding			ovary(1)	1						CAAGAACAACCCACCCACCAT	0.602		NaN											1	0	4.68919e-08	0.008291	5.24909e-08	8	67									
IL17RE	132014	broad.mit.edu	37	3	9956436	9956436	+	Silent	SNP	C	C	G			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr3:9956436C>G	uc003btu.2	+	16	1539	c.1422C>G	c.(1420-1422)GCC>GCG	p.A474A	CIDEC_uc003bto.2_Intron|IL17RC_uc010hcr.2_5'Flank|IL17RC_uc011ato.1_5'Flank|IL17RC_uc010hcs.2_5'Flank|IL17RC_uc003btz.2_5'Flank|IL17RC_uc011atp.1_5'Flank|IL17RC_uc003bud.2_5'Flank|IL17RC_uc003bua.2_5'Flank|IL17RC_uc003bub.2_5'Flank|IL17RC_uc010hct.2_5'Flank|IL17RC_uc010hcu.2_5'Flank|IL17RC_uc010hcv.2_5'Flank|IL17RC_uc011atq.1_5'Flank|IL17RC_uc003buc.2_5'Flank|IL17RE_uc003btw.2_Silent_p.A474A|IL17RE_uc003btx.2_Silent_p.A358A|IL17RE_uc010hcq.2_Missense_Mutation_p.P499A|IL17RE_uc003bty.2_RNA	NM_153483	NP_705616	Q8NFR9	I17RE_HUMAN	interleukin 17 receptor E isoform 1	474	Helical; (Potential).					cytoplasm|extracellular region|integral to membrane	receptor activity			central_nervous_system(1)	1				OV - Ovarian serous cystadenocarcinoma(96;5.34e-64)		TTGTTCTGGCCCTCACCTGCC	0.627		NaN											0	0	0	0.009096	0	3	85									
RFTN1	23180	broad.mit.edu	37	3	16450896	16450896	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr3:16450896C>G	uc003cay.2	-	4	709	c.427G>C	c.(427-429)GAG>CAG	p.E143Q	RFTN1_uc010hes.2_Missense_Mutation_p.E107Q	NM_015150	NP_055965	Q14699	RFTN1_HUMAN	raft-linking protein	143						plasma membrane				ovary(3)|central_nervous_system(1)	4						TTAATGAACTCTGGGATGAGT	0.473		NaN											0	0	0	0.016723	0	10	57									
ZNF385D	79750	broad.mit.edu	37	3	21552474	21552474	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr3:21552474C>G	uc003cce.2	-	4	726	c.318G>C	c.(316-318)AAG>AAC	p.K106N	ZNF385D_uc010hfb.1_RNA	NM_024697	NP_078973	Q9H6B1	Z385D_HUMAN	zinc finger protein 385D	106	Matrin-type 1.					nucleus	nucleic acid binding|zinc ion binding			large_intestine(2)|skin(2)|ovary(1)	5						CTTTGAGCTTCTTGGCATGTT	0.458		NaN											0	0	0	0.013537	0	10	37									
XIRP1	165904	broad.mit.edu	37	3	39225689	39225689	+	Silent	SNP	G	G	A			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr3:39225689G>A	uc003cjk.1	-	2	5469	c.5248C>T	c.(5248-5250)CTG>TTG	p.L1750L	XIRP1_uc003cji.2_3'UTR|XIRP1_uc003cjj.2_Silent_p.L433L	NM_194293	NP_919269	Q702N8	XIRP1_HUMAN	xin actin-binding repeat containing 1	1750	Interaction with FLNC.						actin binding			ovary(4)|breast(2)|central_nervous_system(1)|pancreas(1)	8				KIRC - Kidney renal clear cell carcinoma(284;0.0517)|Kidney(284;0.065)		TGTAGCTCCAGAACACTCTTT	0.562		NaN											0	0	0	0.006999	0	35	166									
SLC6A20	54716	broad.mit.edu	37	3	45800488	45800488	+	Silent	SNP	G	G	A			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr3:45800488G>A	uc011bai.1	-	11	1885	c.1761C>T	c.(1759-1761)GAC>GAT	p.D587D	SLC6A20_uc003cow.2_Silent_p.D237D|SLC6A20_uc011baj.1_Silent_p.D550D	NM_020208	NP_064593	Q9NP91	S6A20_HUMAN	solute carrier family 6, member 20 isoform 1	587	Cytoplasmic (Potential).				cellular nitrogen compound metabolic process|glycine transport|proline transport	apical plasma membrane|integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			ovary(2)	2				BRCA - Breast invasive adenocarcinoma(193;0.01)|KIRC - Kidney renal clear cell carcinoma(197;0.0225)|Kidney(197;0.0267)		CGGGGTCTGCGTCTCCCCTCT	0.577		NaN											0	0	0	0.009096	0	4	53									
ARL13B	200894	broad.mit.edu	37	3	93714777	93714777	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr3:93714777G>T	uc003drc.2	+	2	405	c.119G>T	c.(118-120)GGA>GTA	p.G40V	ARL13B_uc010hop.2_Nonsense_Mutation_p.E10*|ARL13B_uc003drd.2_Intron|ARL13B_uc003dre.2_5'UTR|ARL13B_uc003drf.2_Missense_Mutation_p.G40V|ARL13B_uc003drg.2_Intron	NM_182896	NP_878899	Q3SXY8	AR13B_HUMAN	ADP-ribosylation factor-like 2-like 1 isoform 1	40							GTP binding				0						ACAGCAAAGGGAATCCAAGGA	0.289		NaN											1	0	0.000978159	0.010729	0.00103692	8	39									
PLCH1	23007	broad.mit.edu	37	3	155215191	155215191	+	Silent	SNP	C	C	T			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr3:155215191C>T	uc011bok.1	-	14	2053	c.1776G>A	c.(1774-1776)AGG>AGA	p.R592R	PLCH1_uc011boj.1_Silent_p.R592R|PLCH1_uc011bol.1_Silent_p.R574R	NM_001130960	NP_001124432	Q4KWH8	PLCH1_HUMAN	phospholipase C eta 1 isoform a	592					lipid catabolic process|phosphatidylinositol-mediated signaling	membrane	calcium ion binding|calcium-dependent phospholipase C activity|phosphatidylinositol phospholipase C activity|signal transducer activity			skin(3)|ovary(1)	4			Lung(72;0.11)|LUSC - Lung squamous cell carcinoma(72;0.114)			TCATGGTTTTCCTTCGGCGAC	0.463		NaN											0	0	0	0.006122	0	15	82									
MFN1	55669	broad.mit.edu	37	3	179109794	179109794	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr3:179109794G>C	uc003fjs.2	+	18	2299	c.2173G>C	c.(2173-2175)GAG>CAG	p.E725Q	MFN1_uc010hxb.2_RNA|MFN1_uc003fjt.2_Missense_Mutation_p.E753Q|MFN1_uc010hxc.2_Missense_Mutation_p.E467Q	NM_033540	NP_284941	Q8IWA4	MFN1_HUMAN	mitofusin 1	725	Cytoplasmic (Potential).|Potential.				mitochondrial fusion	integral to membrane|mitochondrial outer membrane	GTP binding|GTPase activity			ovary(2)|large_intestine(1)	3	all_cancers(143;1.67e-16)|Ovarian(172;0.0172)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;5.78e-26)|GBM - Glioblastoma multiforme(14;0.00225)|BRCA - Breast invasive adenocarcinoma(182;0.0923)			ACTTGAAAATGAGCTGGAGAA	0.313		NaN											0	0	0	0.004672	0	3	48									
VPS8	23355	broad.mit.edu	37	3	184714261	184714261	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr3:184714261G>C	uc003fpb.1	+	43	3973	c.3802G>C	c.(3802-3804)GAA>CAA	p.E1268Q	VPS8_uc010hyd.1_Missense_Mutation_p.E1178Q|VPS8_uc010hye.1_Missense_Mutation_p.E697Q	NM_015303	NP_056118	Q8N3P4	VPS8_HUMAN	vacuolar protein sorting 8 homolog isoform b	1270	RING-type; atypical.						zinc ion binding			ovary(1)	1	all_cancers(143;2.51e-11)|Ovarian(172;0.0339)|Breast(254;0.247)		Epithelial(37;1.02e-33)|OV - Ovarian serous cystadenocarcinoma(80;4.81e-22)			GAGACGCCAAGAAATGGCTGA	0.418		NaN											0	0	0	0.009096	0	4	42									
MAP3K13	9175	broad.mit.edu	37	3	185200201	185200201	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr3:185200201C>G	uc010hyf.2	+	15	3124	c.2858C>G	c.(2857-2859)GCC>GGC	p.A953G	MAP3K13_uc011brt.1_Missense_Mutation_p.A746G|MAP3K13_uc011bru.1_Missense_Mutation_p.A809G|MAP3K13_uc003fpi.2_Missense_Mutation_p.A953G|MAP3K13_uc010hyg.2_Missense_Mutation_p.A643G	NM_004721	NP_004712	O43283	M3K13_HUMAN	mitogen-activated protein kinase kinase kinase	953					activation of MAPKK activity|JNK cascade|positive regulation of NF-kappaB transcription factor activity|protein autophosphorylation	cytoplasm|membrane|membrane fraction	ATP binding|magnesium ion binding|MAP kinase kinase kinase activity|protein homodimerization activity|protein kinase binding			ovary(2)|skin(1)	3	all_cancers(143;7.21e-11)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;1.93e-20)			TGTTCTGATGCCACAGTTAGG	0.433		NaN											0	0	0	0.001168	0	4	245									
TNK2	10188	broad.mit.edu	37	3	195610067	195610067	+	Silent	SNP	G	G	A			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr3:195610067G>A	uc003fvu.1	-	5	1113	c.570C>T	c.(568-570)ATC>ATT	p.I190I	TNK2_uc003fvs.1_Silent_p.I222I|TNK2_uc003fvt.1_Silent_p.I253I|TNK2_uc010hzw.1_RNA|TNK2_uc003fvv.1_Silent_p.I20I|TNK2_uc010hzx.1_Silent_p.I204I	NM_005781	NP_005772	Q07912	ACK1_HUMAN	tyrosine kinase, non-receptor, 2 isoform 1	190	Protein kinase.				positive regulation of peptidyl-tyrosine phosphorylation|protein ubiquitination|small GTPase mediated signal transduction	adherens junction|cytoplasmic vesicle membrane|endosome|nucleus	ATP binding|GTPase inhibitor activity|metal ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding			ovary(3)|central_nervous_system(3)|lung(2)|stomach(1)|skin(1)	10	all_cancers(143;6.48e-09)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;1.46e-22)|OV - Ovarian serous cystadenocarcinoma(49;8.3e-19)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;0.000757)	Adenosine triphosphate(DB00171)	CGTAGAGGCGGATGAGGTTTC	0.632		NaN											0	0	0	0.008871	0	17	96									
SLC4A4	8671	broad.mit.edu	37	4	72400084	72400084	+	Silent	SNP	C	C	T			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr4:72400084C>T	uc003hfy.2	+	18	2538	c.2421C>T	c.(2419-2421)AAC>AAT	p.N807N	SLC4A4_uc010iic.2_Silent_p.N807N|SLC4A4_uc010iib.2_Silent_p.N807N|SLC4A4_uc003hfz.2_Silent_p.N807N|SLC4A4_uc003hgc.3_Silent_p.N763N|SLC4A4_uc010iid.2_Silent_p.N11N	NM_001098484	NP_001091954	Q9Y6R1	S4A4_HUMAN	solute carrier family 4, sodium bicarbonate	807	Cytoplasmic (Potential).					basolateral plasma membrane|integral to plasma membrane	inorganic anion exchanger activity|protein binding|sodium:bicarbonate symporter activity			ovary(3)|kidney(1)|skin(1)	5			Lung(101;0.0739)|LUSC - Lung squamous cell carcinoma(112;0.225)			TGATTGTAAACAGGAAAGAAC	0.383		NaN											0	0	0	0.00308	0	7	47									
SLC4A4	8671	broad.mit.edu	37	4	72412136	72412136	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr4:72412136C>T	uc003hfy.2	+	19	2629	c.2512C>T	c.(2512-2514)CTT>TTT	p.L838F	SLC4A4_uc010iic.2_Missense_Mutation_p.L838F|SLC4A4_uc010iib.2_Intron|SLC4A4_uc003hfz.2_Missense_Mutation_p.L838F|SLC4A4_uc003hgc.3_Missense_Mutation_p.L794F|SLC4A4_uc010iid.2_Missense_Mutation_p.L42F	NM_001098484	NP_001091954	Q9Y6R1	S4A4_HUMAN	solute carrier family 4, sodium bicarbonate	838	Helical; (Potential).					basolateral plasma membrane|integral to plasma membrane	inorganic anion exchanger activity|protein binding|sodium:bicarbonate symporter activity			ovary(3)|kidney(1)|skin(1)	5			Lung(101;0.0739)|LUSC - Lung squamous cell carcinoma(112;0.225)			CCTCATGGCTCTTCCGTGGTA	0.463		NaN											0	0	0	0.014323	0	17	104									
HERC5	51191	broad.mit.edu	37	4	89385092	89385092	+	Silent	SNP	G	G	T			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr4:89385092G>T	uc003hrt.2	+	6	1020	c.867G>T	c.(865-867)GTG>GTT	p.V289V		NM_016323	NP_057407	Q9UII4	HERC5_HUMAN	hect domain and RLD 5	289	RCC1 4.				innate immune response|ISG15-protein conjugation|negative regulation of type I interferon production|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|regulation of cyclin-dependent protein kinase activity|regulation of defense response to virus|response to virus	cytosol|perinuclear region of cytoplasm	ISG15 ligase activity|protein binding|ubiquitin-protein ligase activity			ovary(4)|lung(3)|skin(2)	9		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000209)		CCTGTTTGGTGGCTGAGCTTG	0.413		NaN											1	0	3.41278e-10	0.00499	3.95303e-10	15	54									
KIAA1109	84162	broad.mit.edu	37	4	123255651	123255651	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr4:123255651G>C	uc003ieh.2	+	67	11844	c.11799G>C	c.(11797-11799)CAG>CAC	p.Q3933H	KIAA1109_uc003iem.2_Intron	NM_015312	NP_056127	Q2LD37	K1109_HUMAN	fragile site-associated protein	3933					regulation of cell growth|regulation of epithelial cell differentiation	integral to membrane|nucleus				ovary(8)|skin(2)|pancreas(1)|central_nervous_system(1)	12						CCACTGTCCAGAGCAAGACTA	0.408		NaN											0	0	0	0.007835	0	27	100									
PHF17	79960	broad.mit.edu	37	4	129778586	129778586	+	Nonsense_Mutation	SNP	G	G	T			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr4:129778586G>T	uc003igk.2	+	8	1238	c.958G>T	c.(958-960)GAG>TAG	p.E320*	PHF17_uc003igj.2_Nonsense_Mutation_p.E320*|PHF17_uc003igl.2_Nonsense_Mutation_p.E308*|PHF17_uc011cgy.1_Nonsense_Mutation_p.E320*|PHF17_uc003igm.2_Nonsense_Mutation_p.E320*	NM_199320	NP_955352	Q6IE81	JADE1_HUMAN	PHD finger protein 17 long isoform	320	PHD-type 2; atypical.				apoptosis|histone H3 acetylation|histone H4-K12 acetylation|histone H4-K5 acetylation|histone H4-K8 acetylation|negative regulation of cell growth|regulation of transcription, DNA-dependent|response to stress|transcription, DNA-dependent	histone acetyltransferase complex|mitochondrion	protein binding|zinc ion binding				0						CCTCTGCAATGAGAAGTTTGG	0.537		NaN											1	0	2.46787e-29	0.01441	2.92633e-29	43	144									
RNF150	57484	broad.mit.edu	37	4	141888843	141888843	+	Silent	SNP	G	G	T			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr4:141888843G>T	uc003iio.1	-	2	1323	c.669C>A	c.(667-669)TCC>TCA	p.S223S	RNF150_uc010iok.1_Intron|RNF150_uc003iip.1_Silent_p.S223S	NM_020724	NP_065775	Q9ULK6	RN150_HUMAN	ring finger protein 150 precursor	223	Helical; (Potential).					integral to membrane	zinc ion binding			ovary(1)	1	all_hematologic(180;0.162)					GCCATGCGAGGGAAATGATCA	0.423		NaN											1	0	1.99824e-07	0.00499	2.22026e-07	17	92									
GRIA2	2891	broad.mit.edu	37	4	158281083	158281083	+	Silent	SNP	C	C	T			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr4:158281083C>T	uc003ipm.3	+	13	2538	c.2079C>T	c.(2077-2079)ACC>ACT	p.T693T	GRIA2_uc011cit.1_Silent_p.T646T|GRIA2_uc003ipl.3_Silent_p.T693T|GRIA2_uc003ipk.3_Silent_p.T646T|GRIA2_uc010iqh.1_RNA|GRIA2_uc011ciu.1_Silent_p.T3T|GRIA2_uc011civ.1_RNA|GRIA2_uc011ciw.1_RNA|GRIA2_uc011cix.1_Silent_p.T3T|GRIA2_uc011ciy.1_Silent_p.T3T|GRIA2_uc011ciz.1_RNA	NM_001083619	NP_001077088	P42262	GRIA2_HUMAN	glutamate receptor, ionotropic, AMPA 2 isoform 2	693	Extracellular (Potential).				synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|endocytic vesicle membrane|endoplasmic reticulum membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			central_nervous_system(3)|ovary(1)	4	all_hematologic(180;0.24)	Renal(120;0.0458)		COAD - Colon adenocarcinoma(41;0.0294)	L-Glutamic Acid(DB00142)	AAATGTGGACCTACATGCGGA	0.468		NaN											0	0	0	0.001984	0	7	17									
RNASEN	29102	broad.mit.edu	37	5	31472255	31472255	+	Missense_Mutation	SNP	A	A	G			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr5:31472255A>G	uc003jhg.2	-	16	2515	c.2156T>C	c.(2155-2157)ATT>ACT	p.I719T	RNASEN_uc003jhh.2_Missense_Mutation_p.I682T|RNASEN_uc003jhi.2_Missense_Mutation_p.I682T	NM_013235	NP_037367	Q9NRR4	RNC_HUMAN	ribonuclease III, nuclear isoform 1	719	Necessary for interaction with DGCR8 and pri-miRNA processing activity.				gene silencing by RNA|ribosome biogenesis|RNA processing	nucleolus|nucleoplasm	double-stranded RNA binding|metal ion binding|protein binding|ribonuclease III activity				0						CATATTGGCAATCTCCTCCTC	0.512		NaN											0	0	0	0.006999	0	32	130									
FST	10468	broad.mit.edu	37	5	52780943	52780943	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr5:52780943G>C	uc003jpd.2	+	5	865	c.838G>C	c.(838-840)GAT>CAT	p.D280H	FST_uc003jpc.2_Missense_Mutation_p.D280H	NM_013409	NP_037541	P19883	FST_HUMAN	follistatin isoform FST344 precursor	280	Kazal-like 3.				hemopoietic progenitor cell differentiation|negative regulation of activin receptor signaling pathway|negative regulation of follicle-stimulating hormone secretion|negative regulation of transcription from RNA polymerase II promoter|positive regulation of hair follicle development	extracellular region	activin binding|protein binding|signal transducer activity				0		Ovarian(174;1.78e-06)|Lung NSC(810;3.55e-06)|Breast(144;4.08e-05)				CAGTAAGTCGGATGAGCCTGT	0.522		NaN											0	0	0	0.015359	0	31	60									
ERBB2IP	55914	broad.mit.edu	37	5	65290597	65290597	+	Missense_Mutation	SNP	T	T	C			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr5:65290597T>C	uc003juk.1	+	4	520	c.212T>C	c.(211-213)TTA>TCA	p.L71S	ERBB2IP_uc003juh.1_Missense_Mutation_p.L71S|ERBB2IP_uc003jui.1_Missense_Mutation_p.L71S|ERBB2IP_uc003juj.1_Missense_Mutation_p.L71S|ERBB2IP_uc011cqx.1_Missense_Mutation_p.L71S|ERBB2IP_uc011cqy.1_Missense_Mutation_p.L71S|ERBB2IP_uc011cqz.1_Missense_Mutation_p.L71S|ERBB2IP_uc010iwx.1_Missense_Mutation_p.L71S|ERBB2IP_uc003jul.1_Missense_Mutation_p.L71S	NM_018695	NP_061165	Q96RT1	LAP2_HUMAN	ERBB2 interacting protein isoform 2	71	LRR 3.				basal protein localization|cell adhesion|cell cycle|cell growth|epidermal growth factor receptor signaling pathway|establishment or maintenance of epithelial cell apical/basal polarity|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization	basement membrane|cytoplasm|hemidesmosome|nucleus	ErbB-2 class receptor binding|integrin binding|structural constituent of cytoskeleton			ovary(3)|lung(2)|central_nervous_system(2)	7		Lung NSC(167;9.45e-06)|Prostate(74;0.0139)|Ovarian(174;0.0547)|Breast(144;0.093)|Colorectal(97;0.234)		UCEC - Uterine corpus endometrioid carcinoma (4;0.0767)|Lung(70;0.00191)		TGTCAGTCTTTACACAAACTG	0.333		NaN											0	0	0	0.014758	0	5	7									
FNIP1	96459	broad.mit.edu	37	5	130987673	130987673	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr5:130987673G>C	uc003kvs.1	-	16	3270	c.3128C>G	c.(3127-3129)CCA>CGA	p.P1043R	RAPGEF6_uc003kvp.1_Intron|FNIP1_uc003kvt.1_Missense_Mutation_p.P1015R	NM_133372	NP_588613	Q8TF40	FNIP1_HUMAN	folliculin interacting protein 1 isoform 1	1043					regulation of protein phosphorylation	cytoplasm	protein binding			pancreas(1)|skin(1)	2		all_cancers(142;0.00347)|Lung NSC(810;0.106)|all_lung(232;0.123)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	Lung(113;0.0665)		TTCTGCTATTGGTTCATCCAA	0.363		NaN											0	0	0	0.008291	0	9	52									
PCDHGA3	56112	broad.mit.edu	37	5	140723652	140723652	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr5:140723652G>A	uc003ljm.1	+	1	52	c.52G>A	c.(52-54)GCG>ACG	p.A18T	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc010jfx.1_5'UTR|PCDHGA3_uc011dap.1_Missense_Mutation_p.A18T	NM_018916	NP_061739	Q9Y5H0	PCDG3_HUMAN	protocadherin gamma subfamily A, 3 isoform 1	18					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCTGCTGTGCGCGCTCCTGGG	0.537		NaN									OREG0016855	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.001984	0	5	227									
PCDH1	5097	broad.mit.edu	37	5	141244926	141244926	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr5:141244926C>T	uc003llq.2	-	3	1087	c.970G>A	c.(970-972)GAA>AAA	p.E324K	PCDH1_uc003llp.2_Missense_Mutation_p.E324K|PCDH1_uc011dbf.1_Missense_Mutation_p.E302K	NM_002587	NP_002578	Q08174	PCDH1_HUMAN	protocadherin 1 isoform 1 precursor	324	Extracellular (Potential).|Cadherin 3.				cell-cell signaling|homophilic cell adhesion|nervous system development	cell-cell junction|integral to plasma membrane	calcium ion binding			ovary(5)	5		Lung NSC(810;0.027)|all_lung(500;0.0321)|all_hematologic(541;0.0433)|Prostate(461;0.0453)|Breast(839;0.128)|Lung SC(612;0.238)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)	GBM - Glioblastoma multiforme(465;1.06e-05)		CTCACAACTTCGGGCGCCTGG	0.532		NaN											0	0	0	0.016723	0	13	77									
FAT2	2196	broad.mit.edu	37	5	150889707	150889707	+	Silent	SNP	G	G	A			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr5:150889707G>A	uc003lue.3	-	21	11947	c.11934C>T	c.(11932-11934)TTC>TTT	p.F3978F	GM2A_uc011dcs.1_Intron|FAT2_uc003lud.3_Silent_p.F585F	NM_001447	NP_001438	Q9NYQ8	FAT2_HUMAN	FAT tumor suppressor 2 precursor	3978	Extracellular (Potential).|EGF-like 1.				epithelial cell migration|homophilic cell adhesion	cell-cell adherens junction|integral to membrane|nucleus	calcium ion binding			ovary(4)|upper_aerodigestive_tract(1)|skin(1)	6		Medulloblastoma(196;0.0912)|all_hematologic(541;0.104)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			GCTTCCCAGAGAACTGTGGGG	0.522		NaN											0	0	0	0.01441	0	36	96									
HK3	3101	broad.mit.edu	37	5	176308338	176308338	+	Silent	SNP	C	C	G			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr5:176308338C>G	uc003mfa.2	-	18	2684	c.2592G>C	c.(2590-2592)GTG>GTC	p.V864V	HK3_uc003mez.2_Silent_p.V420V	NM_002115	NP_002106	P52790	HXK3_HUMAN	hexokinase 3	864	Catalytic.				glucose transport|glycolysis|transmembrane transport	cytosol|membrane	ATP binding|glucokinase activity			ovary(3)|large_intestine(1)|haematopoietic_and_lymphoid_tissue(1)|breast(1)|skin(1)	7	all_cancers(89;0.000104)|Renal(175;0.000269)|Lung NSC(126;0.00696)|all_lung(126;0.0115)	Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CATCCACCCCCACAGACACTG	0.682		NaN											0	0	0	0.007835	0	33	237									
FOXF2	2295	broad.mit.edu	37	6	1390493	1390493	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr6:1390493C>T	uc003mtm.2	+	1	425	c.311C>T	c.(310-312)TCG>TTG	p.S104L	FOXF2_uc003mtn.2_Missense_Mutation_p.S104L	NM_001452	NP_001443	Q12947	FOXF2_HUMAN	forkhead box F2	104	Fork-head.				epithelial to mesenchymal transition|genitalia development|palate development|pattern specification process|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription factor binding				0	Ovarian(93;0.0733)	all_lung(73;0.0713)|all_hematologic(90;0.0895)		OV - Ovarian serous cystadenocarcinoma(45;0.095)		CCGCCCTACTCGTACATCGCG	0.517		NaN											0	0	0	0.00308	0	6	23									
FAM50B	26240	broad.mit.edu	37	6	3850302	3850302	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr6:3850302G>T	uc003mvu.2	+	2	369	c.257G>T	c.(256-258)CGG>CTG	p.R86L		NM_012135	NP_036267	Q9Y247	FA50B_HUMAN	family with sequence similarity 50, member B	86						nucleus				pancreas(1)	1	Ovarian(93;0.0925)	all_hematologic(90;0.108)				GAGCGCGAGCGGCAGCTGGCC	0.532		NaN											1	0	9.31168e-06	0.016723	1.01582e-05	14	6									
KDM1B	221656	broad.mit.edu	37	6	18212781	18212781	+	Silent	SNP	G	G	A			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr6:18212781G>A	uc003nco.1	+	11	1395	c.1320G>A	c.(1318-1320)TTG>TTA	p.L440L	KDM1B_uc003ncn.1_Silent_p.L411L|KDM1B_uc003ncp.1_5'UTR|KDM1B_uc003ncq.1_5'UTR	NM_153042	NP_694587	Q8NB78	KDM1B_HUMAN	amine oxidase (flavin containing) domain 1	643					multicellular organismal development|regulation of DNA methylation|regulation of gene expression by genetic imprinting|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	histone demethylase activity (H3-dimethyl-K4 specific)|histone demethylase activity (H3-monomethyl-K4 specific)|oxidoreductase activity|zinc ion binding			skin(1)	1						ATCCACCGTTGTCAGAGAAGA	0.403		NaN											0	0	0	0.020292	0	14	142									
HLA-E	3133	broad.mit.edu	37	6	30459140	30459140	+	Silent	SNP	G	G	C			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr6:30459140G>C	uc003nqg.2	+	4	875	c.837G>C	c.(835-837)ACG>ACC	p.T279T	HLA-E_uc011dmg.1_RNA|HLA-E_uc011dmh.1_Silent_p.T320T	NM_005516	NP_005507	P13747	HLAE_HUMAN	major histocompatibility complex, class I, E	279	Ig-like C1-type.|Alpha-3.|Extracellular (Potential).				antigen processing and presentation of peptide antigen via MHC class I|interferon-gamma-mediated signaling pathway|regulation of immune response|type I interferon-mediated signaling pathway	integral to membrane|MHC class I protein complex	MHC class I receptor activity			central_nervous_system(4)|ovary(1)	5						AGAGATACACGTGCCATGTGC	0.622		NaN											0	0	0	0.004672	0	3	110									
C6orf27	80737	broad.mit.edu	37	6	31734367	31734367	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr6:31734367G>A	uc011dog.1	-	14	2295	c.2057C>T	c.(2056-2058)TCG>TTG	p.S686L	C6orf27_uc003nxd.2_Missense_Mutation_p.S361L	NM_025258	NP_079534	Q9Y334	G7C_HUMAN	G7c protein precursor	686						extracellular region				ovary(3)	3						GGGCGACAGCGAGGCTGCGAG	0.692		NaN											0	0	0	0.009096	0	3	57									
ZNF76	7629	broad.mit.edu	37	6	35262967	35262967	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr6:35262967C>T	uc003oki.1	+	14	1860	c.1655C>T	c.(1654-1656)GCG>GTG	p.A552V	ZNF76_uc003okj.1_Missense_Mutation_p.A497V|DEF6_uc003okk.2_5'Flank|DEF6_uc010jvs.2_5'Flank|DEF6_uc010jvt.2_5'Flank	NM_003427	NP_003418	P36508	ZNF76_HUMAN	zinc finger protein 76 (expressed in testis)	552					regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase III promoter|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						GTGGCCACTGCGGCCATGCAG	0.607		NaN											0	0	0	0.004482	0	7	18									
C6orf81	221481	broad.mit.edu	37	6	35716570	35716570	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr6:35716570C>G	uc003ola.2	+	6	1054	c.1027C>G	c.(1027-1029)CTG>GTG	p.L343V	C6orf81_uc003olb.1_Missense_Mutation_p.L306V	NM_145028	NP_659465	Q5T9G4	CF081_HUMAN	hypothetical protein LOC221481	316	ARM 3.						binding			ovary(1)	1						CATTGTCAGCCTGCAGTATCC	0.532		NaN											0	0	0	0.012213	0	30	85									
NFYA	4800	broad.mit.edu	37	6	41051837	41051837	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr6:41051837C>T	uc003opo.2	+	4	393	c.215C>T	c.(214-216)TCA>TTA	p.S72L	NFYA_uc003opp.2_Missense_Mutation_p.S43L|NFYA_uc003opq.2_Missense_Mutation_p.S43L	NM_002505	NP_002496	P23511	NFYA_HUMAN	nuclear transcription factor Y, alpha isoform 1	72	Gln-rich.				transcription from RNA polymerase II promoter	CCAAT-binding factor complex	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity				0	Ovarian(28;0.0418)|Colorectal(47;0.196)					CTAATCACATCAACTGGCCAA	0.453		NaN											0	0	0	0.010729	0	10	58									
GSTA1	2938	broad.mit.edu	37	6	52659018	52659018	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr6:52659018G>C	uc003paz.2	-	5	431	c.319C>G	c.(319-321)CTC>GTC	p.L107V		NM_145740	NP_665683	P08263	GSTA1_HUMAN	glutathione S-transferase alpha 1	107	GST C-terminal.				glutathione metabolic process|xenobiotic metabolic process	cytosol	glutathione transferase activity			ovary(1)	1	Lung NSC(77;0.118)				Amsacrine(DB00276)|Busulfan(DB01008)|Glutathione(DB00143)	GGCAGAAGGAGGATCATTTCA	0.378		NaN											0	0	0	0.008871	0	20	83									
GSTA5	221357	broad.mit.edu	37	6	52701126	52701126	+	Missense_Mutation	SNP	A	A	C			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr6:52701126A>C	uc003pba.1	-	4	250	c.180T>G	c.(178-180)ATT>ATG	p.I60M		NM_153699	NP_714543	Q7RTV2	GSTA5_HUMAN	glutathione S-transferase alpha 5	60	GST N-terminal.				glutathione metabolic process|xenobiotic metabolic process	cytosol	glutathione transferase activity			ovary(1)	1	Lung NSC(77;0.0912)				Glutathione(DB00143)	TCATCCCGTCAATCTCAACCA	0.433		NaN											0	0	0	0.016723	0	13	72									
TINAG	27283	broad.mit.edu	37	6	54173466	54173466	+	Missense_Mutation	SNP	A	A	C			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr6:54173466A>C	uc003pcj.2	+	1	264	c.118A>C	c.(118-120)ACC>CCC	p.T40P	TINAG_uc003pci.2_Missense_Mutation_p.T40P|TINAG_uc010jzt.2_RNA	NM_014464	NP_055279	Q9UJW2	TINAG_HUMAN	tubulointerstitial nephritis antigen	40					cell adhesion|immune response|Malpighian tubule morphogenesis|proteolysis	basement membrane	cysteine-type endopeptidase activity|nucleotide binding|polysaccharide binding|scavenger receptor activity			ovary(3)|central_nervous_system(1)	4	Lung NSC(77;0.0518)		LUSC - Lung squamous cell carcinoma(124;0.246)			TAGGAATCACACCGTTTTGCA	0.398		NaN											0	0	0	0.016522	0	22	46									
ENPP1	5167	broad.mit.edu	37	6	132207839	132207839	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr6:132207839G>A	uc011ecf.1	+	24	2602	c.2582G>A	c.(2581-2583)AGG>AAG	p.R861K		NM_006208	NP_006199	P22413	ENPP1_HUMAN	ectonucleotide pyrophosphatase/phosphodiesterase	861	Nuclease.|Extracellular (Potential).				3'-phosphoadenosine 5'-phosphosulfate metabolic process|biomineral tissue development|cellular phosphate ion homeostasis|cellular response to insulin stimulus|generation of precursor metabolites and energy|immune response|inorganic diphosphate transport|negative regulation of cell growth|negative regulation of fat cell differentiation|negative regulation of glucose import|negative regulation of glycogen biosynthetic process|negative regulation of insulin receptor signaling pathway|negative regulation of protein autophosphorylation|nucleoside triphosphate catabolic process|phosphate metabolic process|sequestering of triglyceride|water-soluble vitamin metabolic process	basolateral plasma membrane|cell surface|extracellular space|integral to membrane	ATP binding|insulin receptor binding|metal ion binding|nucleic acid binding|nucleoside-triphosphate diphosphatase activity|nucleotide diphosphatase activity|phosphodiesterase I activity|polysaccharide binding|protein homodimerization activity|scavenger receptor activity			upper_aerodigestive_tract(2)|ovary(2)	4	Breast(56;0.0505)			GBM - Glioblastoma multiforme(226;0.0216)|OV - Ovarian serous cystadenocarcinoma(155;0.022)	Amifostine(DB01143)|Ribavirin(DB00811)	TTGCCTCACAGGACTGATAAC	0.388		NaN											0	0	0	0.008871	0	16	40									
PBOV1	59351	broad.mit.edu	37	6	138539184	138539184	+	Missense_Mutation	SNP	G	G	C	rs67796103		TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr6:138539184G>C	uc003qhv.2	-	1	444	c.349C>G	c.(349-351)CTA>GTA	p.L117V	KIAA1244_uc003qhu.2_Intron	NM_021635	NP_067648	Q9GZY1	PBOV1_HUMAN	prostate and breast cancer overexpressed 1	117						cytoplasm|nucleus					0	Breast(32;0.135)			OV - Ovarian serous cystadenocarcinoma(155;0.00055)|GBM - Glioblastoma multiforme(68;0.000674)		TCCAGACCTAGGGTCTGAGTT	0.388		NaN											0	0	0	0.010729	0	9	34									
TCP1	6950	broad.mit.edu	37	6	160210477	160210477	+	Silent	SNP	G	G	A			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr6:160210477G>A	uc003qsr.2	-	1	259	c.24C>T	c.(22-24)TTC>TTT	p.F8F	TCP1_uc003qss.2_5'UTR|TCP1_uc010kjz.2_Silent_p.F8F|TCP1_uc003qst.2_5'UTR|TCP1_uc010kka.1_RNA|MRPL18_uc010kkb.2_5'Flank|MRPL18_uc003qsw.3_5'Flank	NM_030752	NP_110379	P17987	TCPA_HUMAN	T-complex protein 1 isoform a	8					'de novo' posttranslational protein folding|tubulin complex assembly	cell junction|Golgi apparatus	ATP binding|unfolded protein binding			breast(1)	1		Breast(66;1.53e-05)|Ovarian(120;0.024)		OV - Ovarian serous cystadenocarcinoma(65;4.05e-20)|BRCA - Breast invasive adenocarcinoma(81;1.1e-06)		TGCGGTCACCGAACACGGACA	0.677		NaN											0	0	0	0.016723	0	11	59									
PDE10A	10846	broad.mit.edu	37	6	165746546	165746546	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr6:165746546C>T	uc003qun.2	-	23	2549	c.2308G>A	c.(2308-2310)GTG>ATG	p.V770M	PDE10A_uc011egj.1_RNA|PDE10A_uc011egk.1_Missense_Mutation_p.V700M|PDE10A_uc003quo.2_Missense_Mutation_p.V780M	NM_006661	NP_006652	Q9Y233	PDE10_HUMAN	phosphodiesterase 10A isoform 2	770					platelet activation|signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cAMP binding|cGMP binding|metal ion binding			ovary(3)|skin(2)	5		Breast(66;0.000425)|Prostate(117;0.104)|Ovarian(120;0.221)		OV - Ovarian serous cystadenocarcinoma(33;1.5e-17)|BRCA - Breast invasive adenocarcinoma(81;1.8e-06)|GBM - Glioblastoma multiforme(31;1.92e-05)	Dipyridamole(DB00975)	TTCTGAGCCACGGATGGGGAT	0.498		NaN											0	0	0	0.004656	0	21	113									
MLLT4	4301	broad.mit.edu	37	6	168272964	168272964	+	Nonsense_Mutation	SNP	C	C	G			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr6:168272964C>G	uc003qwd.2	+	4	624	c.482C>G	c.(481-483)TCA>TGA	p.S161*	MLLT4_uc003qwb.1_Nonsense_Mutation_p.S161*|MLLT4_uc003qwc.1_Nonsense_Mutation_p.S162*	NM_001040001	NP_001035090	P55196	AFAD_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	162	Potential.				adherens junction organization|cell adhesion|cell junction assembly|cell-cell signaling|signal transduction	adherens junction|cell-cell junction|cytosol|nucleus	protein C-terminus binding			ovary(2)|lung(1)|kidney(1)|central_nervous_system(1)	5		Breast(66;1.07e-05)|Ovarian(120;0.024)		Epithelial(4;2.38e-32)|OV - Ovarian serous cystadenocarcinoma(33;9.99e-23)|BRCA - Breast invasive adenocarcinoma(4;1.2e-11)|GBM - Glioblastoma multiforme(31;0.00117)		AGAACTCTCTCaaagaaagaa	0.333		NaN	T	MLL	AL								0	0	0	0.00308	0	7	32									
TTYH3	80727	broad.mit.edu	37	7	2687635	2687635	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr7:2687635C>G	uc003smp.2	+	5	856	c.669C>G	c.(667-669)ATC>ATG	p.I223M	TTYH3_uc010ksn.2_Intron|TTYH3_uc003smq.2_Missense_Mutation_p.I52M	NM_025250	NP_079526	Q9C0H2	TTYH3_HUMAN	tweety 3	223	Helical; Name=3; (Potential).					chloride channel complex|plasma membrane	chloride channel activity				0		Ovarian(82;0.0112)		OV - Ovarian serous cystadenocarcinoma(56;2.04e-14)		ACGTCATCATCTGCCTCCTGG	0.701		NaN											0	0	0	0.00874	0	31	158									
ZDHHC4	55146	broad.mit.edu	37	7	6624725	6624725	+	Missense_Mutation	SNP	G	G	C	rs141408179		TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr7:6624725G>C	uc003sqi.2	+	8	933	c.575G>C	c.(574-576)AGG>ACG	p.R192T	ZDHHC4_uc003sql.2_Missense_Mutation_p.R192T|ZDHHC4_uc003sqh.2_Missense_Mutation_p.R192T|ZDHHC4_uc003sqj.2_Missense_Mutation_p.R192T|ZDHHC4_uc003sqk.2_Missense_Mutation_p.R192T|ZDHHC4_uc003sqm.2_Missense_Mutation_p.R192T	NM_001134388	NP_001127860	Q9NPG8	ZDHC4_HUMAN	zinc finger, DHHC-type containing 4	192	DHHC-type.					integral to membrane	acyltransferase activity|zinc ion binding			breast(1)|pancreas(1)	2		Ovarian(82;0.232)		UCEC - Uterine corpus endometrioid carcinoma (126;0.1)		TGGAACATCAGGTACTTCCTC	0.537		NaN											0	0	0	0.003163	0	12	61									
SCIN	85477	broad.mit.edu	37	7	12668812	12668812	+	Silent	SNP	C	C	G			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr7:12668812C>G	uc003ssn.3	+	9	1494	c.1284C>G	c.(1282-1284)CTC>CTG	p.L428L	SCIN_uc010ktt.2_RNA|SCIN_uc003sso.3_Silent_p.L181L	NM_001112706	NP_001106177	Q9Y6U3	ADSV_HUMAN	scinderin isoform 1	428	Ca(2+)-dependent actin binding.|Gelsolin-like 4.				actin filament capping|actin filament severing|actin nucleation|calcium ion-dependent exocytosis|negative regulation of cell proliferation|positive regulation of apoptosis|positive regulation of megakaryocyte differentiation|positive regulation of secretion|regulation of chondrocyte differentiation	cell cortex|cytoskeleton	1-phosphatidylinositol binding|actin filament binding|calcium ion binding|phosphatidylinositol-4,5-bisphosphate binding|phosphatidylserine binding			ovary(2)	2				UCEC - Uterine corpus endometrioid carcinoma (126;0.195)		ACATCATACTCTACACCTATC	0.418		NaN											0	0	0	0.009535	0	24	98									
C7orf36	57002	broad.mit.edu	37	7	39612143	39612143	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr7:39612143G>C	uc003thc.3	+	3	528	c.519G>C	c.(517-519)AAG>AAC	p.K173N		NM_020192	NP_064577	Q9NRH1	CG036_HUMAN	hypothetical protein LOC57002	173											0						ACTGTAGCAAGAGCCATAGTG	0.393		NaN											0	0	0	0.020292	0	13	100									
PSPH	5723	broad.mit.edu	37	7	56082826	56082826	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr7:56082826C>T	uc003trg.2	-	6	823	c.460G>A	c.(460-462)GAA>AAA	p.E154K	PSPH_uc003trh.2_Missense_Mutation_p.E154K|PSPH_uc003tri.2_Missense_Mutation_p.E154K|PSPH_uc003trj.2_Missense_Mutation_p.E183K	NM_004577	NP_004568	P78330	SERB_HUMAN	phosphoserine phosphatase	154					L-serine biosynthetic process	cytoplasm	calcium ion binding|magnesium ion binding|phosphoserine phosphatase activity|protein homodimerization activity			ovary(1)|skin(1)	2	Breast(14;0.214)		Lung(13;0.00024)|LUSC - Lung squamous cell carcinoma(13;0.00099)			CCACCAGATTCAGCTGTTGGC	0.363		NaN											0	0	0	0.001984	0	7	37									
SEMA3D	223117	broad.mit.edu	37	7	84671545	84671545	+	Silent	SNP	G	G	C			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr7:84671545G>C	uc003uic.2	-	8	958	c.918C>G	c.(916-918)GCC>GCG	p.A306A	SEMA3D_uc010led.2_Silent_p.A306A|SEMA3D_uc003uib.2_5'Flank	NM_152754	NP_689967	O95025	SEM3D_HUMAN	semaphorin 3D precursor	306	Sema.				cell differentiation|nervous system development	extracellular region|membrane	receptor activity			ovary(3)|large_intestine(2)	5						AAATCAGTCTGGCCTTAAGAA	0.383		NaN											0	0	0	0.01441	0	65	81									
PTCD1	26024	broad.mit.edu	37	7	99022928	99022928	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr7:99022928C>G	uc003uqh.2	-	6	1358	c.1227G>C	c.(1225-1227)AAG>AAC	p.K409N	PTCD1_uc011kiw.1_Missense_Mutation_p.K458N	NM_015545	NP_056360	O75127	PTCD1_HUMAN	pentatricopeptide repeat domain 1	409										ovary(1)	1	all_cancers(62;2.54e-08)|all_epithelial(64;2.55e-09)|Lung NSC(181;0.0053)|all_lung(186;0.00895)|Esophageal squamous(72;0.0166)		STAD - Stomach adenocarcinoma(171;0.215)			CTGGTTGGGCCTTGCCGGGCA	0.637		NaN											0	0	0	0.006999	0	32	107									
ZNF498	221785	broad.mit.edu	37	7	99220228	99220228	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr7:99220228G>C	uc003url.1	+	6	973	c.646G>C	c.(646-648)GAG>CAG	p.E216Q	ZNF498_uc003urm.1_Missense_Mutation_p.E52Q|ZNF498_uc010lge.1_Missense_Mutation_p.E52Q|ZNF498_uc003urn.2_RNA|ZNF498_uc010lgf.1_Intron|ZNF498_uc003uro.1_5'UTR	NM_145115	NP_660090	Q6NSZ9	ZN498_HUMAN	zinc finger and SCAN domain containing 25	216					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2	all_epithelial(64;1.95e-08)|Lung NSC(181;0.0066)|all_lung(186;0.011)|Esophageal squamous(72;0.0166)					CAGAGACCAAGAGATGGCAGC	0.532		NaN											0	0	0	0.007291	0	30	85									
ZNF498	221785	broad.mit.edu	37	7	99227017	99227017	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr7:99227017G>A	uc003url.1	+	8	1336	c.1009G>A	c.(1009-1011)GAA>AAA	p.E337K	ZNF498_uc003urm.1_Missense_Mutation_p.E173K|ZNF498_uc010lge.1_Missense_Mutation_p.E173K|ZNF498_uc003urn.2_Intron|ZNF498_uc010lgf.1_Missense_Mutation_p.E265K|ZNF498_uc003uro.1_Missense_Mutation_p.E121K	NM_145115	NP_660090	Q6NSZ9	ZN498_HUMAN	zinc finger and SCAN domain containing 25	337					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2	all_epithelial(64;1.95e-08)|Lung NSC(181;0.0066)|all_lung(186;0.011)|Esophageal squamous(72;0.0166)					CCTGCCTGACGAAGTCAAAAC	0.632		NaN											0	0	0	0.003163	0	13	32									
ZNF498	221785	broad.mit.edu	37	7	99227062	99227062	+	Nonsense_Mutation	SNP	G	G	T			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr7:99227062G>T	uc003url.1	+	8	1381	c.1054G>T	c.(1054-1056)GAG>TAG	p.E352*	ZNF498_uc003urm.1_Nonsense_Mutation_p.E188*|ZNF498_uc010lge.1_Nonsense_Mutation_p.E188*|ZNF498_uc003urn.2_Intron|ZNF498_uc010lgf.1_Nonsense_Mutation_p.E280*|ZNF498_uc003uro.1_Nonsense_Mutation_p.E136*	NM_145115	NP_660090	Q6NSZ9	ZN498_HUMAN	zinc finger and SCAN domain containing 25	352	C2H2-type 1.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2	all_epithelial(64;1.95e-08)|Lung NSC(181;0.0066)|all_lung(186;0.011)|Esophageal squamous(72;0.0166)					CCAGTGCCCTGAGTGTGGGAA	0.587		NaN											1	0	1.5842e-08	0.016723	1.78669e-08	13	44									
MUC17	140453	broad.mit.edu	37	7	100684992	100684992	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr7:100684992C>G	uc003uxp.1	+	3	10348	c.10295C>G	c.(10294-10296)ACT>AGT	p.T3432S	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	3432	Extracellular (Potential).|Ser-rich.|56.|59 X approximate tandem repeats.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					CTGGTGACCACTTCTACTGAA	0.488		NaN											0	0	0	0.001168	0	4	286									
CNTNAP2	26047	broad.mit.edu	37	7	147600711	147600711	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr7:147600711G>A	uc003weu.1	+	14	2669	c.2153G>A	c.(2152-2154)TGG>TAG	p.W718*		NM_014141	NP_054860	Q9UHC6	CNTP2_HUMAN	cell recognition molecule Caspr2 precursor	718	Extracellular (Potential).|Fibrinogen C-terminal.				behavior|cell adhesion|clustering of voltage-gated potassium channels|limbic system development|neuron recognition|signal transduction|striatum development|superior temporal gyrus development|thalamus development|transmission of nerve impulse	axolemma|cell body fiber|dendrite|juxtaparanode region of axon|voltage-gated potassium channel complex	receptor binding			ovary(9)|central_nervous_system(1)|pancreas(1)	11	Melanoma(164;0.153)	all_cancers(3;3.51e-10)|all_epithelial(3;1.4e-05)|Myeloproliferative disorder(3;0.00452)|Lung NSC(3;0.0067)|all_lung(3;0.00794)	OV - Ovarian serous cystadenocarcinoma(82;0.0319)			CACTACTACTGGGGAGGCTCT	0.507		NaN								HNSCC(39;0.1)			0	0	0	0.001168	0	4	25									
SSPO	23145	broad.mit.edu	37	7	149489422	149489422	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr7:149489422G>A	uc010lpk.2	+	38	5575	c.5575G>A	c.(5575-5577)GAG>AAG	p.E1859K		NM_198455	NP_940857	A2VEC9	SSPO_HUMAN	SCO-spondin precursor	1859	EGF-like 1.				cell adhesion	extracellular space	peptidase inhibitor activity				0	Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			GCTGGGCAGCGAGGGGTGGTG	0.687		NaN											0	0	0	0.00308	0	5	9									
UBE3C	9690	broad.mit.edu	37	7	157000422	157000422	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr7:157000422G>C	uc010lqs.2	+	13	1914	c.1602G>C	c.(1600-1602)ATG>ATC	p.M534I	UBE3C_uc003wng.2_Missense_Mutation_p.M534I	NM_014671	NP_055486	Q15386	UBE3C_HUMAN	ubiquitin protein ligase E3C	534					protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus|proteasome complex	protein binding|ubiquitin-protein ligase activity			ovary(2)|lung(2)|large_intestine(1)	5		all_hematologic(28;0.0185)|all_epithelial(9;0.0664)	OV - Ovarian serous cystadenocarcinoma(82;0.00448)	UCEC - Uterine corpus endometrioid carcinoma (81;0.19)		AATCATCAATGATGCCTTTTA	0.373		NaN											0	0	0	0.008291	0	8	46									
CHRNB3	1142	broad.mit.edu	37	8	42586933	42586933	+	Silent	SNP	G	G	T			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr8:42586933G>T	uc003xpi.1	+	5	611	c.483G>T	c.(481-483)CCG>CCT	p.P161P		NM_000749	NP_000740	Q05901	ACHB3_HUMAN	cholinergic receptor, nicotinic, beta	161	Extracellular (Potential).				synaptic transmission, cholinergic	cell junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	nicotinic acetylcholine-activated cation-selective channel activity|receptor activity			ovary(1)	1	all_lung(13;5.7e-12)|Lung NSC(13;1.6e-10)|Ovarian(28;0.00579)|Prostate(17;0.0119)|Lung SC(25;0.184)	all_lung(54;0.00026)|Lung NSC(58;0.000992)|Hepatocellular(245;0.0524)|Renal(179;0.0822)|Esophageal squamous(32;0.0954)	Lung(22;0.0199)|LUSC - Lung squamous cell carcinoma(45;0.0869)			CGTTTTTCCCGTTCGACCGAC	0.488		NaN											1	0	0.00024832	0.009096	0.000267011	3	41									
PRKDC	5591	broad.mit.edu	37	8	48846651	48846651	+	Splice_Site	SNP	C	C	G			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr8:48846651C>G	uc003xqi.2	-	15	1555	c.1498_splice	c.e15-1	p.G500_splice	PRKDC_uc003xqj.2_Splice_Site_p.G500_splice|PRKDC_uc011ldh.1_Splice_Site_p.G500_splice	NM_006904	NP_008835	P78527	PRKDC_HUMAN	protein kinase, DNA-activated, catalytic						cellular response to insulin stimulus|double-strand break repair via nonhomologous end joining|peptidyl-serine phosphorylation|positive regulation of transcription from RNA polymerase II promoter	DNA-dependent protein kinase-DNA ligase 4 complex|transcription factor complex	ATP binding|DNA binding|DNA-dependent protein kinase activity|transcription factor binding			lung(12)|central_nervous_system(9)|ovary(6)|skin(4)|large_intestine(3)	34		all_cancers(86;0.0336)|all_epithelial(80;0.00111)|Lung NSC(129;0.00363)|all_lung(136;0.00391)				ACTCAGGGCCCTGGCCAGAAA	0.473		NaN						NHEJ					0	0	0	0.009096	0	3	159									
MSC	9242	broad.mit.edu	37	8	72755904	72755904	+	Silent	SNP	G	G	A			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr8:72755904G>A	uc003xyx.1	-	1	828	c.510C>T	c.(508-510)AAC>AAT	p.N170N	uc011lff.1_RNA|uc003xyy.2_5'Flank	NM_005098	NP_005089	O60682	MUSC_HUMAN	musculin	170					transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity				0	Breast(64;0.176)		Epithelial(68;0.137)|BRCA - Breast invasive adenocarcinoma(89;0.203)			GCACGTAGCCGTTCTCATAGC	0.662		NaN									OREG0018826	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.021523	0	22	85									
CDH17	1015	broad.mit.edu	37	8	95186397	95186397	+	Silent	SNP	G	G	A			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr8:95186397G>A	uc003ygh.2	-	6	641	c.516C>T	c.(514-516)CCC>CCT	p.P172P	CDH17_uc011lgo.1_Intron|CDH17_uc011lgp.1_Silent_p.P172P	NM_004063	NP_004054	Q12864	CAD17_HUMAN	cadherin 17 precursor	172	Extracellular (Potential).|Cadherin 2.					integral to membrane	calcium ion binding			ovary(5)|skin(1)	6	Breast(36;4.65e-06)		BRCA - Breast invasive adenocarcinoma(8;0.00691)			TGTTGATCATGGGAAGCTGGA	0.488		NaN											0	0	0	0.00623	0	37	340									
RGS22	26166	broad.mit.edu	37	8	101078419	101078419	+	Missense_Mutation	SNP	A	A	C			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr8:101078419A>C	uc003yjb.1	-	7	895	c.700T>G	c.(700-702)TCA>GCA	p.S234A	RGS22_uc003yja.1_Missense_Mutation_p.S53A|RGS22_uc003yjc.1_Missense_Mutation_p.S222A|RGS22_uc011lgz.1_RNA|RGS22_uc010mbo.1_RNA	NM_015668	NP_056483	Q8NE09	RGS22_HUMAN	regulator of G-protein signaling 22	234					negative regulation of signal transduction	cytoplasm|plasma membrane	GTPase activator activity|signal transducer activity			ovary(3)|skin(2)|breast(1)|central_nervous_system(1)	7			Epithelial(11;6.71e-08)|all cancers(13;4.19e-06)|OV - Ovarian serous cystadenocarcinoma(57;0.000469)|STAD - Stomach adenocarcinoma(118;0.169)			ATAGCTGGTGATTTAAGTTTG	0.338		NaN											0	0	0	0.010729	0	10	92									
PABPC1	26986	broad.mit.edu	37	8	101721413	101721413	+	Silent	SNP	A	A	G			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr8:101721413A>G	uc003yjs.1	-	9	1788	c.1284T>C	c.(1282-1284)ATT>ATC	p.I428I	PABPC1_uc011lhc.1_Silent_p.I396I|PABPC1_uc011lhd.1_Silent_p.I383I|PABPC1_uc003yjt.1_Silent_p.I425I|PABPC1_uc003yju.2_RNA	NM_002568	NP_002559	P11940	PABP1_HUMAN	poly(A) binding protein, cytoplasmic 1	428				I -> V (in Ref. 1; CAA68428).	mRNA polyadenylation|mRNA stabilization|negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA poly(A) tail shortening|translation	catalytic step 2 spliceosome|cytosol	nucleotide binding|poly(A) RNA binding|protein C-terminus binding|translation activator activity				0	all_cancers(14;6.8e-05)|all_epithelial(15;3.16e-07)|Lung NSC(17;0.000453)|all_lung(17;0.00125)		Epithelial(11;6.37e-11)|all cancers(13;1.11e-08)|OV - Ovarian serous cystadenocarcinoma(57;3.91e-05)|STAD - Stomach adenocarcinoma(118;0.206)			TTAGTTGAGCAATTTGGCTAG	0.393		NaN											0	0	0	0.01441	0	49	280									
ZFPM2	23414	broad.mit.edu	37	8	106813404	106813404	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr8:106813404G>A	uc003ymd.2	+	8	1117	c.1094G>A	c.(1093-1095)TGT>TAT	p.C365Y	ZFPM2_uc011lhs.1_Missense_Mutation_p.C96Y|uc003yme.1_5'Flank	NM_012082	NP_036214	Q8WW38	FOG2_HUMAN	zinc finger protein, multitype 2	365	C2H2-type 3.				blood coagulation|negative regulation of fat cell differentiation|outflow tract septum morphogenesis|right ventricular cardiac muscle tissue morphogenesis|ventricular septum morphogenesis	nucleoplasm	DNA binding|RNA polymerase II transcription coactivator activity|transcription corepressor activity|transcription factor binding|zinc ion binding			ovary(4)|large_intestine(1)	5			OV - Ovarian serous cystadenocarcinoma(57;8.28e-08)			GCCTTCCGATGTAATCACTGC	0.502		NaN											0	0	0	0.011902	0	41	344									
CSMD3	114788	broad.mit.edu	37	8	113358438	113358438	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr8:113358438C>G	uc003ynu.2	-	41	6489	c.6330G>C	c.(6328-6330)CAG>CAC	p.Q2110H	CSMD3_uc003yns.2_Missense_Mutation_p.Q1312H|CSMD3_uc003ynt.2_Missense_Mutation_p.Q2070H|CSMD3_uc011lhx.1_Missense_Mutation_p.Q2006H	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	2110	Extracellular (Potential).					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						CACCACCACACTGAGCTGCAA	0.383		NaN								HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			0	0	0	0.009096	0	4	81									
ZHX2	22882	broad.mit.edu	37	8	123963985	123963985	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr8:123963985G>C	uc003ypk.1	+	3	802	c.235G>C	c.(235-237)GAG>CAG	p.E79Q		NM_014943	NP_055758	Q9Y6X8	ZHX2_HUMAN	zinc fingers and homeoboxes 2	79	C2H2-type 1.					cytoplasm|nucleus|plasma membrane	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|skin(1)	2	Lung NSC(37;2e-09)|Ovarian(258;0.0205)|Hepatocellular(40;0.105)		STAD - Stomach adenocarcinoma(47;0.00527)			AGGTGGTTATGAGTGCAAATA	0.483		NaN											0	0	0	0.006214	0	7	94									
ADCY8	114	broad.mit.edu	37	8	131848566	131848566	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr8:131848566C>T	uc003ytd.3	-	12	2888	c.2632G>A	c.(2632-2634)GCA>ACA	p.A878T	ADCY8_uc010mds.2_Missense_Mutation_p.A747T	NM_001115	NP_001106	P40145	ADCY8_HUMAN	adenylate cyclase 8	878	Helical; (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|membrane fraction|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|metal ion binding			skin(4)|large_intestine(1)|central_nervous_system(1)	6	Esophageal squamous(12;0.00693)|Ovarian(258;0.00707)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000538)			AAGAGGCCTGCGTAGACGGTC	0.542		NaN								HNSCC(32;0.087)			0	0	0	0.01892	0	22	163									
CYP11B2	1585	broad.mit.edu	37	8	143993439	143993439	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr8:143993439C>G	uc003yxk.1	-	9	1472	c.1469G>C	c.(1468-1470)AGG>ACG	p.R490T		NM_000498	NP_000489	P19099	C11B2_HUMAN	cytochrome P450, family 11, subfamily B,	490					aldosterone biosynthetic process|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|potassium ion homeostasis|regulation of blood volume by renal aldosterone|sodium ion homeostasis|xenobiotic metabolic process		corticosterone 18-monooxygenase activity|electron carrier activity|steroid 11-beta-monooxygenase activity				0	all_cancers(97;5.56e-11)|all_epithelial(106;2.49e-08)|Lung NSC(106;0.000228)|all_lung(105;0.000633)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)				Candesartan(DB00796)|Metyrapone(DB01011)	CGTGCCAGGCCTCAATATGAA	0.562		NaN							Familial_Hyperaldosteronism_type_I				0	0	0	0.006122	0	14	147									
NFKBIL2	4796	broad.mit.edu	37	8	145665527	145665527	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr8:145665527C>T	uc011llg.1	-	11	1372	c.1357G>A	c.(1357-1359)GAA>AAA	p.E453K		NM_013432	NP_038460	Q96HA7	TONSL_HUMAN	NF-kappa-B inhibitor-like protein 2	453	Glu-rich.				cytoplasmic sequestering of transcription factor|double-strand break repair via homologous recombination|replication fork processing	cytoplasm|nuclear replication fork	histone binding|transcription corepressor activity				0	all_cancers(97;4.61e-11)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.08e-41)|Epithelial(56;8.67e-41)|all cancers(56;1.1e-35)|BRCA - Breast invasive adenocarcinoma(115;0.035)|Colorectal(110;0.055)			AGTCTGGTTTCGGTCTCAGGG	0.522		NaN											0	0	0	0.01441	0	32	112									
PTPRD	5789	broad.mit.edu	37	9	8500765	8500765	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr9:8500765G>C	uc003zkk.2	-	23	2828	c.2117C>G	c.(2116-2118)ACC>AGC	p.T706S	PTPRD_uc003zkp.2_Intron|PTPRD_uc003zkq.2_Intron|PTPRD_uc003zkr.2_Intron|PTPRD_uc003zks.2_Intron|PTPRD_uc003zkl.2_Missense_Mutation_p.T706S|PTPRD_uc003zkm.2_Missense_Mutation_p.T693S|PTPRD_uc003zkn.2_Intron|PTPRD_uc003zko.2_Intron	NM_002839	NP_002830	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	706	Fibronectin type-III 4.|Extracellular (Potential).				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			lung(14)|large_intestine(3)|ovary(2)|breast(2)|urinary_tract(1)	22		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		ATCTTCATTGGTTCGAATCAA	0.478		NaN								TSP Lung(15;0.13)			0	0	0	0.013726	0	29	51									
UBAP2	55833	broad.mit.edu	37	9	33941739	33941739	+	Missense_Mutation	SNP	T	T	C			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr9:33941739T>C	uc003ztq.1	-	16	1950	c.1837A>G	c.(1837-1839)ATG>GTG	p.M613V	UBAP2_uc011loc.1_Missense_Mutation_p.M522V|UBAP2_uc011lod.1_Missense_Mutation_p.M346V|UBAP2_uc011loe.1_Missense_Mutation_p.M368V|UBAP2_uc011lof.1_Missense_Mutation_p.M538V|UBAP2_uc011log.1_Missense_Mutation_p.M559V|UBAP2_uc003ztr.2_Missense_Mutation_p.M485V|UBAP2_uc003zts.2_Missense_Mutation_p.M246V	NM_018449	NP_060919	Q5T6F2	UBAP2_HUMAN	ubiquitin associated protein 2	613										ovary(3)	3			LUSC - Lung squamous cell carcinoma(29;0.00575)	GBM - Glioblastoma multiforme(74;0.168)		GAGGAAGACATTGCTACTGGA	0.463		NaN											0	0	0	0.001984	0	7	54									
ALDH1A1	216	broad.mit.edu	37	9	75526950	75526950	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr9:75526950C>G	uc004ajd.2	-	10	1177	c.1124G>C	c.(1123-1125)TGG>TCG	p.W375S	ALDH1A1_uc011lsh.1_Missense_Mutation_p.W296S|ALDH1A1_uc011lsg.1_Missense_Mutation_p.W201S	NM_000689	NP_000680	P00352	AL1A1_HUMAN	aldehyde dehydrogenase 1A1	375					cellular aldehyde metabolic process|ethanol oxidation|xenobiotic metabolic process	cytosol	aldehyde dehydrogenase (NAD) activity|androgen binding|Ras GTPase activator activity|retinal dehydrogenase activity			ovary(3)|lung(1)	4					NADH(DB00157)|Tretinoin(DB00755)|Vitamin A(DB00162)	TTTATTCCCCCACGGGCCTCC	0.433		NaN											0	0	0	0.012319	0	18	70									
CDC14B	8555	broad.mit.edu	37	9	99327675	99327675	+	Missense_Mutation	SNP	T	T	A			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr9:99327675T>A	uc004awj.2	-	2	703	c.251A>T	c.(250-252)AAC>ATC	p.N84I	CDC14B_uc004awk.2_Missense_Mutation_p.N84I|CDC14B_uc004awl.2_RNA|CDC14B_uc004awi.2_Missense_Mutation_p.N47I	NM_033331	NP_201588	O60729	CC14B_HUMAN	CDC14 homolog B isoform 2	84	A.				activation of anaphase-promoting complex activity|DNA repair|G2/M transition DNA damage checkpoint	nucleolus|nucleoplasm	protein binding|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(1)	1		Acute lymphoblastic leukemia(62;0.0559)				CAATACTTACTTCTCATATTC	0.313		NaN											0	0	0	0.00308	0	7	40									
ZNF483	158399	broad.mit.edu	37	9	114296106	114296106	+	Nonsense_Mutation	SNP	G	G	T			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr9:114296106G>T	uc004bff.2	+	4	813	c.589G>T	c.(589-591)GAA>TAA	p.E197*	ZNF483_uc011lwq.1_Nonsense_Mutation_p.E197*|ZNF483_uc004bfg.2_Nonsense_Mutation_p.E197*	NM_133464	NP_597721	Q8TF39	ZN483_HUMAN	zinc finger protein 483 isoform a	197	KRAB.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(1)	1						GCTATATAAGGAAGTGCTACT	0.398		NaN											1	0	0.000673444	0.008291	0.00071643	9	29									
GLE1	2733	broad.mit.edu	37	9	131286012	131286012	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr9:131286012C>A	uc004bvj.2	+	6	898	c.784C>A	c.(784-786)CTG>ATG	p.L262M	GLE1_uc004bvi.2_Missense_Mutation_p.L262M|GLE1_uc010myd.2_Missense_Mutation_p.L8M	NM_001003722	NP_001003722	Q53GS7	GLE1_HUMAN	GLE1 RNA export mediator homolog isoform 1	262	Potential.				poly(A)+ mRNA export from nucleus|protein transport|transmembrane transport	cytoplasm|nuclear pore	protein binding				0						CAGCCAGCAGCTGGATGCCTC	0.612		NaN											1	0	1.12685e-05	0.004482	1.22484e-05	8	35									
SPTAN1	6709	broad.mit.edu	37	9	131387392	131387392	+	Silent	SNP	G	G	A			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr9:131387392G>A	uc004bvl.3	+	46	6101	c.5988G>A	c.(5986-5988)GAG>GAA	p.E1996E	SPTAN1_uc004bvm.3_Silent_p.E2001E|SPTAN1_uc004bvn.3_Silent_p.E1976E|SPTAN1_uc010mye.1_5'Flank|SPTAN1_uc010myf.1_5'Flank	NM_003127	NP_003118	Q13813	SPTA2_HUMAN	spectrin, alpha, non-erythrocytic 1	1996	Spectrin 21.				actin filament capping|axon guidance|cellular component disassembly involved in apoptosis	cytosol|intracellular membrane-bounded organelle|membrane fraction|microtubule cytoskeleton|spectrin	actin binding|calcium ion binding|calmodulin binding|structural constituent of cytoskeleton			breast(5)|ovary(4)|pancreas(1)	10						GTGAAAAGGAGAACAGCTTGA	0.448		NaN											0	0	0	0.004482	0	7	48									
TBC1D13	54662	broad.mit.edu	37	9	131553894	131553894	+	Silent	SNP	G	G	C			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr9:131553894G>C	uc010myj.2	+	5	345	c.222G>C	c.(220-222)CTG>CTC	p.L74L	TBC1D13_uc010myk.2_Silent_p.L74L|TBC1D13_uc010myl.2_Intron	NM_018201	NP_060671	Q9NVG8	TBC13_HUMAN	TBC1 domain family, member 13	74	Rab-GAP TBC.					intracellular	Rab GTPase activator activity				0						CCCAGTTCCTGAGGGAAATGA	0.577		NaN											0	0	0	0.003163	0	15	65									
PNPLA7	375775	broad.mit.edu	37	9	140354928	140354928	+	Nonsense_Mutation	SNP	C	C	A			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr9:140354928C>A	uc004cnf.2	-	34	4208	c.3871G>T	c.(3871-3873)GAG>TAG	p.E1291*	C9orf167_uc011mew.1_Intron|PNPLA7_uc004cnd.1_Nonsense_Mutation_p.E538*|PNPLA7_uc004cne.1_Nonsense_Mutation_p.E557*|PNPLA7_uc011mfa.1_Nonsense_Mutation_p.E699*|PNPLA7_uc010ncj.1_Nonsense_Mutation_p.E1316*|NELF_uc011mey.1_5'Flank|NELF_uc004cna.2_5'Flank|NELF_uc011mez.1_5'Flank|NELF_uc004cmz.2_5'Flank|NELF_uc004cnc.2_5'Flank|NELF_uc004cnb.2_5'Flank	NM_152286	NP_689499	Q6ZV29	PLPL7_HUMAN	patatin-like phospholipase domain containing 7	1291					lipid metabolic process	endoplasmic reticulum|integral to membrane|lysosomal membrane|microsome|mitochondrial membrane|nuclear membrane	hydrolase activity			skin(1)	1	all_cancers(76;0.126)			OV - Ovarian serous cystadenocarcinoma(145;0.000268)|Epithelial(140;0.000839)		GACTCGTCCTCCTGCAAGCAG	0.637		NaN											1	0	3.65163e-15	0.00632	4.27925e-15	25	28									
PNPLA7	375775	broad.mit.edu	37	9	140437237	140437237	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr9:140437237C>T	uc004cnf.2	-	6	785	c.448G>A	c.(448-450)GAG>AAG	p.E150K	PNPLA7_uc010ncj.1_Missense_Mutation_p.E175K	NM_152286	NP_689499	Q6ZV29	PLPL7_HUMAN	patatin-like phospholipase domain containing 7	150	cNMP 1.				lipid metabolic process	endoplasmic reticulum|integral to membrane|lysosomal membrane|microsome|mitochondrial membrane|nuclear membrane	hydrolase activity			skin(1)	1	all_cancers(76;0.126)			OV - Ovarian serous cystadenocarcinoma(145;0.000268)|Epithelial(140;0.000839)		AGCGGCTTCTCAAAGTGGCCC	0.622		NaN											0	0	0	0.00499	0	12	71									
IQSEC2	23096	broad.mit.edu	37	X	53270978	53270978	+	Missense_Mutation	SNP	A	A	T			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chrX:53270978A>T	uc004dsd.2	-	10	3204	c.3003T>A	c.(3001-3003)AAT>AAA	p.N1001K	IQSEC2_uc004dsc.2_Missense_Mutation_p.N796K	NM_001111125	NP_001104595	Q5JU85	IQEC2_HUMAN	IQ motif and Sec7 domain 2 isoform1	991	PH.				regulation of ARF protein signal transduction	cytoplasm	ARF guanyl-nucleotide exchange factor activity			ovary(3)	3						CAAGGAGATCATTGAAGAGGA	0.557		NaN											0	0	0	0.008291	0	9	29									
HEPH	9843	broad.mit.edu	37	X	65476064	65476064	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chrX:65476064G>A	uc011moz.1	+	17	2857	c.2797G>A	c.(2797-2799)GAA>AAA	p.E933K	HEPH_uc004dwn.2_Missense_Mutation_p.E933K|HEPH_uc004dwo.2_Missense_Mutation_p.E663K|HEPH_uc010nkr.2_Missense_Mutation_p.E741K|HEPH_uc011mpa.1_Missense_Mutation_p.E933K|HEPH_uc010nks.2_Missense_Mutation_p.E222K	NM_138737	NP_620074	Q9BQS7	HEPH_HUMAN	hephaestin isoform a	930	Extracellular (Potential).|Plastocyanin-like 6.				cellular iron ion homeostasis|copper ion transport|transmembrane transport	integral to membrane|plasma membrane	copper ion binding|oxidoreductase activity			lung(5)|ovary(4)	9						GATTTTTGATGAAAATAAGTC	0.473		NaN											0	0	0	0.016723	0	13	25									
ARMCX1	51309	broad.mit.edu	37	X	100808026	100808026	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chrX:100808026G>C	uc004ehv.2	+	4	484	c.113G>C	c.(112-114)TGG>TCG	p.W38S	ARMCX1_uc004ehw.2_Missense_Mutation_p.W38S	NM_016608	NP_057692	Q9P291	ARMX1_HUMAN	armadillo repeat containing, X-linked 1	38						integral to membrane	binding			ovary(3)|pancreas(1)	4						GAGAAAATCTGGGACGAAGAC	0.567		NaN											0	0	0	0.006214	0	9	26									
MORF4L2	9643	broad.mit.edu	37	X	102931203	102931203	+	Silent	SNP	T	T	C			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chrX:102931203T>C	uc004ekw.2	-	4	1985	c.753A>G	c.(751-753)TTA>TTG	p.L251L	MORF4L2_uc004ela.2_Silent_p.L251L|MORF4L2_uc004ekx.2_Silent_p.L251L|MORF4L2_uc004elb.2_Silent_p.L251L|MORF4L2_uc004eky.2_Silent_p.L251L|MORF4L2_uc010nos.2_Silent_p.L251L|MORF4L2_uc004ekz.2_Silent_p.L251L|MORF4L2_uc011mry.1_Silent_p.L251L|MORF4L2_uc011mrz.1_Silent_p.L251L|MORF4L2_uc004elc.2_Silent_p.L251L|MORF4L2_uc004elf.2_Silent_p.L251L|MORF4L2_uc004ele.2_Silent_p.L251L|MORF4L2_uc011msa.1_Silent_p.L251L|MORF4L2_uc011msb.1_Silent_p.L251L|MORF4L2_uc011msc.1_Silent_p.L251L|MORF4L2_uc011msd.1_Silent_p.L251L|MORF4L2_uc004eld.2_Silent_p.L251L	NM_012286	NP_036418	Q15014	MO4L2_HUMAN	mortality factor 4 like 2	251					chromatin modification|DNA repair|regulation of cell growth|transcription, DNA-dependent	nucleolus	protein binding				0						AGCCCAACAATAATGCAAGGC	0.423		NaN											0	0	0	0.009096	0	4	32									
ITPKB	3707	broad.mit.edu	37	1	226924876	226924884	+	In_Frame_Del	DEL	CTGCCGCTG	CTGCCGCTG	-	rs11278152		TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr1:226924876_226924884delCTGCCGCTG	uc010pvo.1	-	2	616_624	c.276_284delCAGCGGCAG	c.(274-285)AGCAGCGGCAGT>AGT	p.92_95SSGS>S	ITPKB_uc001hqh.2_In_Frame_Del_p.92_95SSGS>S	NM_002221	NP_002212	P27987	IP3KB_HUMAN	1D-myo-inositol-trisphosphate 3-kinase B	92_95							ATP binding|calmodulin binding|inositol trisphosphate 3-kinase activity			ovary(4)|central_nervous_system(1)	5		Prostate(94;0.0773)				GCTCACgctactgccgctgctgccgctgc	0.617		NaN											NaN	NaN	NaN	NaN	NaN	3	5	---	---							
SF1	7536	broad.mit.edu	37	11	64533611	64533631	+	Splice_Site	DEL	GGTGGTAGTCGTCGTATCTGG	GGTGGTAGTCGTCGTATCTGG	-			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr11:64533611_64533631delGGTGGTAGTCGTCGTATCTGG	uc001obb.1	-	13	1960	c.1583_splice	c.e13-1	p.N528_splice	SF1_uc010rnm.1_Intron|SF1_uc010rnn.1_Splice_Site_p.N502_splice|SF1_uc001oaz.1_Intron|SF1_uc001oba.1_Splice_Site_p.N528_splice|SF1_uc001obc.1_Intron|SF1_uc001obd.1_Intron|SF1_uc001obe.1_Intron|SF1_uc010rno.1_Intron	NM_004630	NP_004621	Q15637	SF01_HUMAN	splicing factor 1 isoform 1						nuclear mRNA 3'-splice site recognition|regulation of transcription, DNA-dependent|transcription, DNA-dependent	ribosome|spliceosomal complex	protein binding|RNA binding|transcription corepressor activity|zinc ion binding			ovary(1)|breast(1)|skin(1)	3						CAGCGCTCGTGGTGGTAGTCGTCGTATCTGGGGTGGTAAAG	0.67		NaN											NaN	NaN	NaN	NaN	NaN	11	62	---	---							
DUSP6	1848	broad.mit.edu	37	12	89743323	89743341	+	Splice_Site	DEL	TTGCCCCGGGCTTCATCTG	TTGCCCCGGGCTTCATCTG	-			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr12:89743323_89743341delTTGCCCCGGGCTTCATCTG	uc001tay.2	-	3	1319	c.839_splice	c.e3-1	p.D280_splice	DUSP6_uc001taz.2_Splice_Site_p.D134_splice	NM_001946	NP_001937	Q16828	DUS6_HUMAN	dual specificity phosphatase 6 isoform a						dorsal/ventral pattern formation|inactivation of MAPK activity|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of ERK1 and ERK2 cascade|nerve growth factor receptor signaling pathway|positive regulation of apoptosis|regulation of endodermal cell fate specification|regulation of fibroblast growth factor receptor signaling pathway|regulation of heart growth|response to nitrosative stress|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	MAP kinase tyrosine/serine/threonine phosphatase activity|protein tyrosine phosphatase activity				0						ACCACAGTTCTTGCCCCGGGCTTCATCTGTGAACACAAA	0.425		NaN											NaN	NaN	NaN	NaN	NaN	14	59	---	---							
PCMTD2	55251	broad.mit.edu	37	20	62895852	62895854	+	In_Frame_Del	DEL	CTT	CTT	-			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr20:62895852_62895854delCTT	uc002yil.3	+	3	578_580	c.378_380delCTT	c.(376-381)GACTTC>GAC	p.F128del	PCMTD2_uc002yim.3_In_Frame_Del_p.F128del	NM_018257	NP_060727	Q9NV79	PCMD2_HUMAN	protein-L-isoaspartate (D-aspartate)	128						cytoplasm	protein-L-isoaspartate (D-aspartate) O-methyltransferase activity				0	all_cancers(38;1.82e-11)|all_epithelial(29;3.3e-13)|Lung NSC(23;5.21e-10)|all_lung(23;1.92e-09)					AGAAACTGGACTTCTTCATCAGA	0.355		NaN											NaN	NaN	NaN	NaN	NaN	8	74	---	---							
HHATL	57467	broad.mit.edu	37	3	42740315	42740317	+	In_Frame_Del	DEL	AGC	AGC	-			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr3:42740315_42740317delAGC	uc003clw.2	-	6	513_515	c.366_368delGCT	c.(364-369)CTGCTT>CTT	p.122_123LL>L	HHATL_uc003clx.2_In_Frame_Del_p.122_123LL>L	NM_020707	NP_065758	Q9HCP6	HHATL_HUMAN	hedgehog acyltransferase-like	122_123					negative regulation of N-terminal protein palmitoylation	endoplasmic reticulum membrane|integral to membrane|perinuclear region of cytoplasm				ovary(3)	3				KIRC - Kidney renal clear cell carcinoma(284;0.215)		ACAGTGACCAAGCAGCAGCAGCA	0.621		NaN											NaN	NaN	NaN	NaN	NaN	7	139	---	---							
OR2B3	442184	broad.mit.edu	37	6	29054200	29054200	+	Frame_Shift_Del	DEL	G	G	-			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr6:29054200delG	uc003nlx.2	-	1	891	c.826delC	c.(826-828)CTCfs	p.L276fs		NM_001005226	NP_001005226			olfactory receptor, family 2, subfamily B,											skin(1)	1						CCATAGAAGAGGGAAACCATC	0.433		NaN											NaN	NaN	NaN	NaN	NaN	7	35	---	---