Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	isArtifactMode	oxoGCut	pox	pox_cutoff	qox	t_alt_count	t_ref_count	validation_alt_allele	validation_tumor_sample							
H6PD	9563	broad.mit.edu	37	1	9324741	9324741	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr1:9324741G>T	uc001apt.2	+	5	2462	c.2189G>T	c.(2188-2190)AGC>ATC	p.S730I		NM_004285	NP_004276	O95479	G6PE_HUMAN	hexose-6-phosphate dehydrogenase precursor	730	6-phosphogluconolactonase.					endoplasmic reticulum lumen	6-phosphogluconolactonase activity|glucose 1-dehydrogenase|glucose-6-phosphate dehydrogenase activity|NADP binding				0	all_lung(157;0.23)	all_epithelial(116;1.28e-19)|all_lung(118;5.22e-06)|Lung NSC(185;1.98e-05)|Renal(390;0.000147)|Breast(348;0.00109)|Colorectal(325;0.00205)|Hepatocellular(190;0.00825)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;1.88e-07)|COAD - Colon adenocarcinoma(227;7.47e-05)|Kidney(185;0.000244)|KIRC - Kidney renal clear cell carcinoma(229;0.000905)|STAD - Stomach adenocarcinoma(132;0.00176)|BRCA - Breast invasive adenocarcinoma(304;0.00183)|READ - Rectum adenocarcinoma(331;0.0419)	NADH(DB00157)	CGCCGCATGAGCCTTAGCCTG	0.652		NaN											1	0	3.27435e-08	0.00245	3.62959e-08	8	27									
DDI2	84301	broad.mit.edu	37	1	15978267	15978267	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr1:15978267C>G	uc001awx.1	+	8	1156	c.1060C>G	c.(1060-1062)CCT>GCT	p.P354A	DDI2_uc009voj.1_Missense_Mutation_p.P95A	NM_032341	NP_115717	Q5TDH0	DDI2_HUMAN	DNA-damage inducible protein 2	354					proteolysis		aspartic-type endopeptidase activity				0		Colorectal(325;0.00108)|Renal(390;0.00145)|Breast(348;0.00327)|Lung NSC(340;0.00566)|all_lung(284;0.00831)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0798)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;9.03e-07)|COAD - Colon adenocarcinoma(227;4.48e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000133)|KIRC - Kidney renal clear cell carcinoma(229;0.00262)|STAD - Stomach adenocarcinoma(313;0.00773)|READ - Rectum adenocarcinoma(331;0.0656)		CACCTTTCTTCCTGAGGGAGA	0.502		NaN											0	0	0	0.010729	0	9	50									
GRHL3	57822	broad.mit.edu	37	1	24668758	24668758	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr1:24668758G>T	uc001biy.2	+	9	1262	c.1216G>T	c.(1216-1218)GAC>TAC	p.D406Y	GRHL3_uc001bix.2_Missense_Mutation_p.D401Y|GRHL3_uc001biz.2_Missense_Mutation_p.D308Y	NM_021180	NP_067003	Q8TE85	GRHL3_HUMAN	sister-of-mammalian grainyhead protein isoform	401					regulation of actin cytoskeleton organization|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(1)	1		Colorectal(325;3.46e-05)|Renal(390;0.0007)|Lung NSC(340;0.00171)|all_lung(284;0.00226)|Ovarian(437;0.00348)|Breast(348;0.0126)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.19)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;8.72e-25)|Colorectal(126;4.38e-08)|COAD - Colon adenocarcinoma(152;1.84e-06)|GBM - Glioblastoma multiforme(114;0.000132)|BRCA - Breast invasive adenocarcinoma(304;0.00105)|STAD - Stomach adenocarcinoma(196;0.00151)|KIRC - Kidney renal clear cell carcinoma(1967;0.00377)|READ - Rectum adenocarcinoma(331;0.0656)|Lung(427;0.143)		GATCTTCTGTGACAAGGTGGC	0.577		NaN											1	0	2.43468e-25	0.01441	3.16105e-25	41	30									
EXTL1	2134	broad.mit.edu	37	1	26349272	26349272	+	Silent	SNP	C	C	T			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr1:26349272C>T	uc001blf.2	+	1	1002	c.135C>T	c.(133-135)GGC>GGT	p.G45G		NM_004455	NP_004446	Q92935	EXTL1_HUMAN	exostoses-like 1	45	Lumenal (Potential).				skeletal system development	integral to membrane|intrinsic to endoplasmic reticulum membrane	glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity|protein binding			central_nervous_system(1)	1		Colorectal(325;3.46e-05)|Lung NSC(340;6.18e-05)|all_lung(284;9.43e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0155)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0298)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;6.44e-26)|Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.000716)|BRCA - Breast invasive adenocarcinoma(304;0.000954)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.00594)|READ - Rectum adenocarcinoma(331;0.0649)		CTTCCCAAGGCTGGCCCCGCT	0.652		NaN											0	0	0	0.004482	0	7	9									
UBXN11	91544	broad.mit.edu	37	1	26610895	26610895	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr1:26610895G>A	uc001blw.2	-	12	1204	c.931C>T	c.(931-933)CAG>TAG	p.Q311*	UBXN11_uc001blz.1_Nonsense_Mutation_p.Q278*|UBXN11_uc001blv.2_Nonsense_Mutation_p.Q273*|UBXN11_uc001bly.2_Nonsense_Mutation_p.Q191*|UBXN11_uc001blx.2_Nonsense_Mutation_p.Q69*|UBXN11_uc001bma.2_Nonsense_Mutation_p.Q278*|UBXN11_uc001bmb.1_Nonsense_Mutation_p.Q311*|UBXN11_uc010ofb.1_3'UTR|UBXN11_uc010ofc.1_3'UTR	NM_183008	NP_892120	Q5T124	UBX11_HUMAN	socius isoform 2	311						cytoplasm|cytoskeleton				ovary(1)	1						TGCATCAGCTGCCTGCCCACC	0.627		NaN											0	0	0	0.00499	0	14	33									
GRIK3	2899	broad.mit.edu	37	1	37270762	37270762	+	Silent	SNP	C	C	T			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr1:37270762C>T	uc001caz.2	-	15	2526	c.2391G>A	c.(2389-2391)GAG>GAA	p.E797E	GRIK3_uc001cba.1_Silent_p.E797E	NM_000831	NP_000822	Q13003	GRIK3_HUMAN	glutamate receptor, ionotropic, kainate 3	797	Extracellular (Potential).				negative regulation of synaptic transmission, glutamatergic|regulation of membrane potential|synaptic transmission	cell junction|dendrite cytoplasm|integral to plasma membrane|perikaryon|postsynaptic membrane|terminal button	adenylate cyclase inhibiting metabotropic glutamate receptor activity|extracellular-glutamate-gated ion channel activity|G-protein-coupled receptor binding|kainate selective glutamate receptor activity			ovary(3)|skin(2)|large_intestine(1)|breast(1)	7		Myeloproliferative disorder(586;0.0258)|all_neural(195;0.169)			L-Glutamic Acid(DB00142)	GCCACCACTTCTCCTTCATGA	0.602		NaN											0	0	0	0.014323	0	20	62									
MACF1	23499	broad.mit.edu	37	1	39802313	39802313	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr1:39802313C>A	uc010oiu.1	+	1	5504	c.5373C>A	c.(5371-5373)TTC>TTA	p.F1791L	MACF1_uc010ois.1_Intron|MACF1_uc001cda.1_Intron|MACF1_uc001cdc.1_Intron|MACF1_uc001cdb.1_Intron	NM_033044	NP_149033	Q9UPN3	MACF1_HUMAN	microfilament and actin filament cross-linker	3356					cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			ovary(8)|breast(3)|central_nervous_system(3)|skin(2)	16	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			CAGAGCCCTTCAGAGCAACTC	0.418		NaN											1	0	9.31168e-06	0.001855	9.90156e-06	12	10									
PTPRF	5792	broad.mit.edu	37	1	44086245	44086245	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr1:44086245G>T	uc001cjr.2	+	31	5699	c.5359G>T	c.(5359-5361)GCC>TCC	p.A1787S	PTPRF_uc001cjs.2_Missense_Mutation_p.A1778S|PTPRF_uc001cju.2_Missense_Mutation_p.A1176S|PTPRF_uc009vwt.2_Missense_Mutation_p.A1347S|PTPRF_uc001cjv.2_Missense_Mutation_p.A1258S|PTPRF_uc001cjw.2_Missense_Mutation_p.A1013S	NM_002840	NP_002831	P10586	PTPRF_HUMAN	protein tyrosine phosphatase, receptor type, F	1787	Tyrosine-protein phosphatase 2.|Cytoplasmic (Potential).				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			ovary(4)|skin(3)|lung(1)|kidney(1)|central_nervous_system(1)	10	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0333)				GGTCACGGATGCCCGGGTGAG	0.552		NaN											1	0	3.07415e-52	0.01441	4.17588e-52	113	126									
PODN	127435	broad.mit.edu	37	1	53540317	53540317	+	Missense_Mutation	SNP	A	A	G			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr1:53540317A>G	uc001cuv.2	+	4	597	c.590A>G	c.(589-591)AAT>AGT	p.N197S	PODN_uc001cuw.2_Missense_Mutation_p.N178S|PODN_uc010onr.1_Missense_Mutation_p.N178S|PODN_uc010ons.1_Intron	NM_153703	NP_714914	Q7Z5L7	PODN_HUMAN	podocan	149	LRR 3.				negative regulation of cell migration|negative regulation of cell proliferation	cytoplasm|extracellular space|proteinaceous extracellular matrix	collagen binding			ovary(1)|pancreas(1)	2						ACCAACCTCAATTACCTGTAC	0.562		NaN											0	0	0	0.01441	0	50	192									
USP24	23358	broad.mit.edu	37	1	55562240	55562240	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr1:55562240C>A	uc001cyg.3	-	47	5512	c.5512G>T	c.(5512-5514)GAC>TAC	p.D1838Y		NM_015306	NP_056121	Q9UPU5	UBP24_HUMAN	ubiquitin specific protease 24	1998					ubiquitin-dependent protein catabolic process		binding|cysteine-type peptidase activity|ubiquitin thiolesterase activity			ovary(6)|kidney(6)|breast(1)	13						TCATTTAGGTCAAATTCTTCT	0.323		NaN											1	0	1.36615e-20	0.013726	1.69865e-20	28	11									
PRKAA2	5563	broad.mit.edu	37	1	57169954	57169954	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr1:57169954C>A	uc001cyk.3	+	7	1170	c.1099C>A	c.(1099-1101)CCA>ACA	p.P367T		NM_006252	NP_006243	P54646	AAPK2_HUMAN	AMP-activated protein kinase alpha 2 catalytic	367					carnitine shuttle|cell cycle arrest|cholesterol biosynthetic process|energy reserve metabolic process|fatty acid biosynthetic process|insulin receptor signaling pathway|regulation of fatty acid biosynthetic process|regulation of fatty acid oxidation	cytosol|nucleoplasm	ATP binding|metal ion binding			breast(4)|ovary(1)|stomach(1)	6						GAAACCTCATCCAGAAAGGAT	0.468		NaN											1	0	1.96642e-18	0.006999	2.39434e-18	36	20									
GPSM2	29899	broad.mit.edu	37	1	109439511	109439511	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr1:109439511G>T	uc010ovc.1	+	3	578	c.82G>T	c.(82-84)GCC>TCC	p.A28S	AKNAD1_uc010ovb.1_Intron|GPSM2_uc010ovd.1_Missense_Mutation_p.A28S|GPSM2_uc010ove.1_Missense_Mutation_p.A28S	NM_013296	NP_037428	P81274	GPSM2_HUMAN	LGN protein	28	TPR 1.				G-protein coupled receptor protein signaling pathway	cell cortex|nucleus	GTPase activator activity|identical protein binding			central_nervous_system(1)	1		all_epithelial(167;7.64e-05)|all_lung(203;0.000321)|Lung NSC(277;0.000626)		Colorectal(144;0.0353)|Lung(183;0.0984)|COAD - Colon adenocarcinoma(174;0.129)|Epithelial(280;0.175)|all cancers(265;0.209)		CCTAGAGCTGGCCTTGGAAGG	0.418		NaN											1	0	2.79147e-13	0.01441	3.27997e-13	40	135									
OR10T2	128360	broad.mit.edu	37	1	158369175	158369175	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr1:158369175G>A	uc010pih.1	-	1	82	c.82C>T	c.(82-84)CTT>TTT	p.L28F		NM_001004475	NP_001004475	Q8NGX3	O10T2_HUMAN	olfactory receptor, family 10, subfamily T,	28	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|central_nervous_system(1)	3	all_hematologic(112;0.0378)					ATGACAAAAAGCAGCAGCTGG	0.488		NaN											0	0	0	0.00308	0	6	27									
ATP1A2	477	broad.mit.edu	37	1	160109741	160109741	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr1:160109741G>A	uc001fvc.2	+	22	3133	c.3001G>A	c.(3001-3003)GTC>ATC	p.V1001I	ATP1A2_uc001fvd.2_Missense_Mutation_p.V720I	NM_000702	NP_000693	P50993	AT1A2_HUMAN	Na+/K+ -ATPase alpha 2 subunit proprotein	1001	Helical; (Potential).				ATP biosynthetic process		ATP binding|metal ion binding|sodium:potassium-exchanging ATPase activity			central_nervous_system(3)|ovary(2)|skin(2)	7	all_cancers(52;1.11e-16)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)|LUSC - Lung squamous cell carcinoma(543;0.246)			CTATGATGAGGTCCGAAAGCT	0.582		NaN											0	0	0	0.011902	0	33	68									
LMX1A	4009	broad.mit.edu	37	1	165175152	165175152	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr1:165175152G>A	uc001gcy.1	-	7	1158	c.937C>T	c.(937-939)CGA>TGA	p.R313*	LMX1A_uc001gcz.1_Nonsense_Mutation_p.R313*|LMX1A_uc001gcw.1_Nonsense_Mutation_p.R31*|LMX1A_uc001gcx.1_Nonsense_Mutation_p.R64*	NM_177398	NP_796372	Q8TE12	LMX1A_HUMAN	LIM homeobox transcription factor 1, alpha	313						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(3)|upper_aerodigestive_tract(1)|pancreas(1)	5	all_hematologic(923;0.248)					AGACCCTGTCGGAAGGGATCT	0.582		NaN											0	0	0	0.010504	0	18	56									
LRRC52	440699	broad.mit.edu	37	1	165532872	165532872	+	Silent	SNP	C	C	T			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr1:165532872C>T	uc001gde.2	+	2	809	c.753C>T	c.(751-753)ATC>ATT	p.I251I	LOC400794_uc001gdc.2_Intron|LOC400794_uc001gdd.2_Intron|LOC400794_uc009wvd.2_Intron	NM_001005214	NP_001005214	Q8N7C0	LRC52_HUMAN	leucine rich repeat containing 52 precursor	251	Helical; (Potential).					integral to membrane				ovary(1)	1	all_hematologic(923;0.0773)|Acute lymphoblastic leukemia(8;0.155)					TGCTGCTCATCGGCTTCTGCA	0.587		NaN											0	0	0	0.003163	0	13	35									
FMO3	2328	broad.mit.edu	37	1	171073019	171073019	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr1:171073019G>A	uc001ghi.2	+	3	337	c.226G>A	c.(226-228)GAT>AAT	p.D76N	FMO3_uc001ghh.2_Missense_Mutation_p.D76N|FMO3_uc010pmb.1_Missense_Mutation_p.D56N|FMO3_uc010pmc.1_Intron|MIR1295_hsa-mir-1295|MI0006357_5'Flank	NM_001002294	NP_001002294	P31513	FMO3_HUMAN	flavin containing monooxygenase 3	76					xenobiotic metabolic process	integral to membrane|intrinsic to endoplasmic reticulum membrane|microsome	flavin adenine dinucleotide binding|flavin-containing monooxygenase activity			skin(1)	1	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					CCCATTTCCCGATGACTTCCC	0.423		NaN											0	0	0	0.012213	0	31	20									
FMO2	2327	broad.mit.edu	37	1	171162520	171162520	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr1:171162520C>T	uc001ghk.1	+	3	296	c.179C>T	c.(178-180)ACC>ATC	p.T60I	FMO2_uc010pmd.1_5'UTR	NM_001460	NP_001451	Q99518	FMO2_HUMAN	flavin containing monooxygenase 2	60					drug metabolic process|NADPH oxidation|organic acid metabolic process|toxin metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|host cell microsome|integral to membrane|microsome	flavin adenine dinucleotide binding|flavin-containing monooxygenase activity|NADP binding			skin(1)	1	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					TCTGTCGTTACCAACACCAGC	0.348		NaN											0	0	0	0.01441	0	75	62									
KDM5B	10765	broad.mit.edu	37	1	202709880	202709880	+	Silent	SNP	T	T	C			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr1:202709880T>C	uc001gyf.2	-	20	3122	c.3006A>G	c.(3004-3006)GCA>GCG	p.A1002A	KDM5B_uc009xag.2_Silent_p.A1038A|KDM5B_uc001gyg.1_Silent_p.A844A	NM_006618	NP_006609	Q9UGL1	KDM5B_HUMAN	jumonji, AT rich interactive domain 1B	1002					negative regulation of transcription, DNA-dependent	nucleolus	DNA binding|histone demethylase activity (H3-dimethyl-K4 specific)|histone demethylase activity (H3-trimethyl-K4 specific)|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			ovary(2)|breast(2)|urinary_tract(1)	5						TGGGCAGATATGCAGGGATCT	0.443		NaN											0	0	0	0.001855	0	11	47									
MDM4	4194	broad.mit.edu	37	1	204511994	204511994	+	Silent	SNP	G	G	A			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr1:204511994G>A	uc001hba.2	+	8	756	c.594G>A	c.(592-594)CTG>CTA	p.L198L	MDM4_uc001hbd.1_RNA|MDM4_uc010pqw.1_RNA|MDM4_uc010pqx.1_Silent_p.L71L|MDM4_uc001hay.1_Silent_p.L198L|MDM4_uc001hbb.2_Silent_p.L71L|MDM4_uc010pqy.1_Intron|MDM4_uc001hbc.2_RNA|MDM4_uc009xbe.1_RNA	NM_002393	NP_002384	O15151	MDM4_HUMAN	mouse double minute 4 homolog	198					apoptosis|cell proliferation|cellular response to hypoxia|G0 to G1 transition|negative regulation of apoptosis|negative regulation of cell cycle arrest|negative regulation of cell proliferation|negative regulation of protein catabolic process|negative regulation of transcription from RNA polymerase II promoter|protein complex assembly|protein stabilization	nucleus	enzyme binding|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	3	all_cancers(21;0.00146)|all_neural(3;0.0218)|Glioma(3;0.0382)|Breast(84;0.112)|all_epithelial(62;0.118)|Prostate(682;0.227)		GBM - Glioblastoma multiforme(2;3.15e-47)|all cancers(3;3.56e-32)|KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|Epithelial(59;0.143)|BRCA - Breast invasive adenocarcinoma(75;0.143)			TAGCTGGCCTGCCTTGGTGGT	0.388		NaN	A		GBM|bladder|retinoblastoma								0	0	0	0.00278	0	19	39									
SRGAP2	23380	broad.mit.edu	37	1	206626557	206626557	+	Missense_Mutation	SNP	A	A	G			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr1:206626557A>G	uc001hdy.2	+	17	2263	c.1930A>G	c.(1930-1932)ATC>GTC	p.I644V	SRGAP2_uc010prt.1_Missense_Mutation_p.I567V|SRGAP2_uc001hdx.2_Missense_Mutation_p.I644V|SRGAP2_uc010pru.1_Missense_Mutation_p.I567V|SRGAP2_uc010prv.1_Missense_Mutation_p.I568V	NM_015326	NP_056141	O75044	FNBP2_HUMAN	SLIT-ROBO Rho GTPase activating protein 2	731	SH3.				axon guidance|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|protein binding				0	Breast(84;0.137)					ATGTGAGCCCATCGAGGCCAT	0.522		NaN											0	0	0	0.004672	0	2	2									
MYO3A	53904	broad.mit.edu	37	10	26463335	26463335	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr10:26463335C>T	uc001isn.2	+	30	4502	c.4142C>T	c.(4141-4143)ACA>ATA	p.T1381I	MYO3A_uc009xkp.1_Intron|MYO3A_uc009xkq.1_Intron	NM_017433	NP_059129	Q8NEV4	MYO3A_HUMAN	myosin IIIA	1381					protein autophosphorylation|response to stimulus|sensory perception of sound|visual perception	cytoplasm|filamentous actin|filopodium|myosin complex	actin binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|plus-end directed microfilament motor activity|protein serine/threonine kinase activity			ovary(6)|stomach(3)|lung(3)|central_nervous_system(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	18						AGGATTGTCACAACACCAACA	0.398		NaN											0	0	0	0.01441	0	44	66									
ZNF25	219749	broad.mit.edu	37	10	38241661	38241661	+	Silent	SNP	C	C	T			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr10:38241661C>T	uc001ize.1	-	6	870	c.765G>A	c.(763-765)GAG>GAA	p.E255E	ZNF25_uc001izf.1_Silent_p.E219E	NM_145011	NP_659448	P17030	ZNF25_HUMAN	zinc finger protein 25	255					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|ovary(1)|central_nervous_system(1)	4		all_neural(218;0.0218)|Breast(68;0.0389)|Ovarian(717;0.0443)|Renal(717;0.157)				CATAGGGTTTCTCCCCTGTGT	0.443		NaN											0	0	0	0.006999	0	36	96									
LRIT1	26103	broad.mit.edu	37	10	85997383	85997383	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr10:85997383G>A	uc001kcz.1	-	2	204	c.182C>T	c.(181-183)ACC>ATC	p.T61I		NM_015613	NP_056428	Q9P2V4	LRIT1_HUMAN	retina specific protein PAL	61	LRR 1.|Lumenal (Potential).					integral to endoplasmic reticulum membrane					0						CAGTCTGGAGGTGTCCGGGGG	0.662		NaN											0	0	0	0.01441	0	44	9									
GRK5	2869	broad.mit.edu	37	10	121189924	121189924	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr10:121189924G>A	uc001led.2	+	7	804	c.571G>A	c.(571-573)GTG>ATG	p.V191M	GRK5_uc009xzh.2_Missense_Mutation_p.V86M|GRK5_uc010qta.1_Missense_Mutation_p.V86M	NM_005308	NP_005299	P34947	GRK5_HUMAN	G protein-coupled receptor kinase 5	191	Protein kinase.				G-protein signaling, coupled to cAMP nucleotide second messenger|regulation of G-protein coupled receptor protein signaling pathway|tachykinin receptor signaling pathway	cytoplasm|plasma membrane|soluble fraction	ATP binding|G-protein coupled receptor kinase activity|phospholipid binding|protein kinase C binding|signal transducer activity			lung(2)|stomach(1)	3		Lung NSC(174;0.0971)|all_lung(145;0.127)|Ovarian(717;0.249)		all cancers(201;0.0227)		GCAGTATCGAGTGCTAGGAAA	0.458		NaN											0	0	0	0.01441	0	46	54									
C10orf88	80007	broad.mit.edu	37	10	124692098	124692098	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr10:124692098C>A	uc001lgw.2	-	6	1408	c.1183G>T	c.(1183-1185)GAT>TAT	p.D395Y	C10orf88_uc001lgx.2_Missense_Mutation_p.D297Y	NM_024942	NP_079218	Q9H8K7	CJ088_HUMAN	hypothetical protein LOC80007	395											0		all_neural(114;0.0765)|Lung NSC(174;0.163)|all_lung(145;0.205)		Colorectal(40;0.0686)|COAD - Colon adenocarcinoma(40;0.0735)		TCAATGTAATCCATAAGTTTC	0.353		NaN											1	0	2.0095e-06	0.001984	2.18626e-06	6	24									
LRDD	55367	broad.mit.edu	37	11	800221	800221	+	Silent	SNP	C	C	T			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr11:800221C>T	uc001lro.1	-	14	2326	c.2184G>A	c.(2182-2184)GTG>GTA	p.V728V	SLC25A22_uc009yci.2_5'Flank|SLC25A22_uc001lrj.2_5'Flank|LRDD_uc009yck.1_RNA|LRDD_uc001lrk.1_Silent_p.V711V|LRDD_uc001lrl.1_Silent_p.V571V|LRDD_uc001lrm.1_Silent_p.V415V|LRDD_uc001lrn.1_Silent_p.V571V|LRDD_uc001lrp.1_Silent_p.V373V	NM_145886	NP_665893	Q9HB75	PIDD_HUMAN	leucine rich repeat and death domain containing	728					apoptosis|signal transduction	cytoplasm|nucleus	death receptor binding				0		all_cancers(49;1.13e-08)|all_epithelial(84;2.95e-05)|Breast(177;0.000286)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.159)|all_lung(207;0.198)		all cancers(45;1.45e-25)|Epithelial(43;1.17e-24)|OV - Ovarian serous cystadenocarcinoma(40;6.76e-19)|BRCA - Breast invasive adenocarcinoma(625;4.23e-05)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)		CCCGCACAGGCACCGCGCCAC	0.687		NaN											0	0	0	0.008291	0	8	18									
ABCC8	6833	broad.mit.edu	37	11	17414623	17414623	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr11:17414623C>A	uc001mnc.2	-	39	4787	c.4661G>T	c.(4660-4662)GGT>GTT	p.G1554V		NM_000352	NP_000343	Q09428	ABCC8_HUMAN	ATP-binding cassette, sub-family C, member 8	1554	Cytoplasmic (By similarity).|ABC transporter 2.				carbohydrate metabolic process|energy reserve metabolic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium ion transmembrane transporter activity|sulfonylurea receptor activity			ovary(1)	1				READ - Rectum adenocarcinoma(2;0.0325)|Colorectal(2;0.1)	Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)|Gliclazide(DB01120)|Mitiglinide(DB01252)|Nateglinide(DB00731)|Repaglinide(DB00912)	AAGGATGGCACCCCGCTTCAG	0.617		NaN											1	0	7.48243e-07	0.006214	8.25526e-07	9	25									
NELL1	4745	broad.mit.edu	37	11	20940871	20940871	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr11:20940871G>C	uc001mqe.2	+	7	903	c.750G>C	c.(748-750)ATG>ATC	p.M250I	NELL1_uc001mqf.2_Missense_Mutation_p.M250I|NELL1_uc009yid.2_Missense_Mutation_p.M278I|NELL1_uc010rdo.1_Missense_Mutation_p.M193I|NELL1_uc010rdp.1_Missense_Mutation_p.M10I	NM_006157	NP_006148	Q92832	NELL1_HUMAN	nel-like 1 isoform 1 precursor	250					cell adhesion|nervous system development	extracellular region	calcium ion binding|structural molecule activity			ovary(2)|large_intestine(1)	3						TGGCCAAGATGACTGCAAAAG	0.323		NaN											0	0	0	0.003755	0	28	40									
MAPK8IP1	9479	broad.mit.edu	37	11	45924441	45924441	+	Missense_Mutation	SNP	T	T	C			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr11:45924441T>C	uc001nbr.2	+	5	1293	c.1123T>C	c.(1123-1125)TCC>CCC	p.S375P		NM_005456	NP_005447	Q9UQF2	JIP1_HUMAN	mitogen-activated protein kinase 8 interacting	375					vesicle-mediated transport	nucleus|perinuclear region of cytoplasm	kinesin binding|MAP-kinase scaffold activity|protein kinase inhibitor activity			ovary(2)|breast(1)|skin(1)	4				GBM - Glioblastoma multiforme(35;0.231)		CAGCGCCCTGTCCTATGACTC	0.672		NaN											0	0	0	0.001984	0	5	3									
OR4C15	81309	broad.mit.edu	37	11	55322269	55322269	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr11:55322269G>T	uc010rig.1	+	1	487	c.487G>T	c.(487-489)GTG>TTG	p.V163L		NM_001001920	NP_001001920	Q8NGM1	OR4CF_HUMAN	olfactory receptor, family 4, subfamily C,	109	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						CTTTGCTGGGGTGGAGGTGAT	0.473		NaN								HNSCC(20;0.049)			1	0	6.21321e-17	0.00278	7.48772e-17	19	124									
STX5	6811	broad.mit.edu	37	11	62592798	62592798	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr11:62592798G>C	uc001nvh.2	-	7	708	c.554C>G	c.(553-555)TCT>TGT	p.S185C	STX5_uc010rmi.1_Missense_Mutation_p.S89C|STX5_uc009yoh.2_RNA|STX5_uc001nvi.2_Missense_Mutation_p.S131C|STX5_uc010rmj.1_Missense_Mutation_p.S185C|STX5_uc001nvj.2_5'UTR	NM_003164	NP_003155	Q13190	STX5_HUMAN	syntaxin 5	185	Cytoplasmic (Potential).				intracellular protein transport|retrograde transport, endosome to Golgi|vesicle targeting	ER-Golgi intermediate compartment membrane|Golgi membrane|integral to membrane|nucleus|SNARE complex	protein N-terminus binding|SNAP receptor activity			ovary(1)|breast(1)	2						ATTGGACATAGAAGCCAGTTT	0.493		NaN											0	0	0	0.01441	0	234	155									
NRXN2	9379	broad.mit.edu	37	11	64374714	64374714	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr11:64374714G>A	uc001oap.2	-	8	2466	c.1955C>T	c.(1954-1956)ACG>ATG	p.T652M	NRXN2_uc001oar.2_Missense_Mutation_p.T1698M|NRXN2_uc001oas.2_Missense_Mutation_p.T1628M|NRXN2_uc001oao.2_Missense_Mutation_p.T338M|NRXN2_uc001oaq.2_Missense_Mutation_p.T1365M	NM_138734	NP_620063	P58401	NRX2B_HUMAN	neurexin 2 isoform beta precursor	652	Cytoplasmic (Potential).				cell adhesion	integral to membrane				upper_aerodigestive_tract(2)|central_nervous_system(2)|skin(2)|ovary(2)|kidney(1)|pancreas(1)	10						CTTGCTGGGCGTCTTGGGGGC	0.637		NaN											0	0	0	0.008291	0	9	31									
NRXN2	9379	broad.mit.edu	37	11	64428312	64428312	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr11:64428312G>A	uc001oar.2	-	11	2537	c.2098C>T	c.(2098-2100)CGC>TGC	p.R700C	NRXN2_uc001oas.2_Missense_Mutation_p.R669C|NRXN2_uc001oaq.2_Missense_Mutation_p.R367C	NM_015080	NP_055895	P58401	NRX2B_HUMAN	neurexin 2 isoform alpha-1 precursor	Error:Variant_position_missing_in_P58401_after_alignment					cell adhesion	integral to membrane				upper_aerodigestive_tract(2)|central_nervous_system(2)|skin(2)|ovary(2)|kidney(1)|pancreas(1)	10						CCCCCATTGCGACAGGGGGCA	0.647		NaN											0	0	0	0.01441	0	41	29									
SAC3D1	29901	broad.mit.edu	37	11	64811717	64811717	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr11:64811717G>A	uc001ocm.2	+	2	984	c.595G>A	c.(595-597)GAG>AAG	p.E199K	SAC3D1_uc010rnv.1_Missense_Mutation_p.E186K	NM_013299	NP_037431			SAC3 domain containing 1												0						AGCCCTGCATGAGGTTCTACA	0.642		NaN											0	0	0	0.003163	0	14	56									
SNX32	254122	broad.mit.edu	37	11	65617466	65617466	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr11:65617466G>T	uc001ofr.2	+	3	344	c.217G>T	c.(217-219)GCC>TCC	p.A73S	SNX32_uc009yqt.2_3'UTR|SNX32_uc010rop.1_Missense_Mutation_p.A73S	NM_152760	NP_689973	Q86XE0	SNX32_HUMAN	sorting nexin 6B	73	PX.				cell communication|protein transport		phosphatidylinositol binding				0				READ - Rectum adenocarcinoma(159;0.171)		GCTGCATGATGCCTACGTGGA	0.632		NaN											1	0	1.56738e-10	0.004289	1.78803e-10	31	22									
RBM14	10432	broad.mit.edu	37	11	66384255	66384255	+	Missense_Mutation	SNP	T	T	A			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr11:66384255T>A	uc001oit.2	+	1	203	c.64T>A	c.(64-66)TTT>ATT	p.F22I	RBM14_uc009yrh.2_Missense_Mutation_p.F22I|RBM14_uc009yri.2_Missense_Mutation_p.F22I|RBM4_uc009yrj.2_5'UTR|RBM4_uc009yrk.2_Missense_Mutation_p.F22I	NM_006328	NP_006319	Q96PK6	RBM14_HUMAN	RNA binding motif protein 14	22	RRM 1.				DNA recombination|DNA repair|DNA replication|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|histone deacetylation|positive regulation of transcription from RNA polymerase II promoter|response to hormone stimulus	mediator complex|ribonucleoprotein complex|transcription factor complex	ligand-dependent nuclear receptor transcription coactivator activity|nucleotide binding|protein binding, bridging|RNA binding|RNA polymerase II transcription cofactor activity			ovary(2)|central_nervous_system(1)	3						GGCAGCCCTCTTTGCGCCCTA	0.647		NaN											0	0	0	0.000602	0	4	17									
DNAJB13	374407	broad.mit.edu	37	11	73670624	73670624	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr11:73670624G>C	uc001ouo.2	+	3	1009	c.258G>C	c.(256-258)TGG>TGC	p.W86C		NM_153614	NP_705842	P59910	DJB13_HUMAN	testis spermatogenesis apoptosis-related protein	86					apoptosis|protein folding|spermatogenesis		heat shock protein binding|unfolded protein binding				0	Breast(11;7.42e-05)					AGACCCCATGGACAACTGGTT	0.522		NaN											0	0	0	0.01441	0	73	23									
C2CD3	26005	broad.mit.edu	37	11	73817441	73817441	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr11:73817441C>A	uc001ouu.2	-	13	2287	c.2060G>T	c.(2059-2061)GGT>GTT	p.G687V		NM_015531	NP_056346	Q4AC94	C2CD3_HUMAN	C2 calcium-dependent domain containing 3	687						centrosome				ovary(4)|pancreas(2)|skin(1)	7	Breast(11;4.16e-06)					TGGAGACTGACCATTTTCTTG	0.383		NaN											1	0	2.32173e-10	0.004878	2.63579e-10	30	87									
CAPN5	726	broad.mit.edu	37	11	76796098	76796098	+	Splice_Site	SNP	G	G	T			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr11:76796098G>T	uc001oxx.2	+	2	350	c.165_splice	c.e2+1	p.K55_splice	CAPN5_uc009yup.2_Splice_Site_p.K55_splice|CAPN5_uc009yuq.2_Splice_Site_p.K91_splice|CAPN5_uc001oxy.2_Splice_Site_p.K95_splice	NM_004055	NP_004046	O15484	CAN5_HUMAN	calpain 5						proteolysis|signal transduction	intracellular	calcium-dependent cysteine-type endopeptidase activity				0						GCGACCCAAGGTCAGTGTCTG	0.677		NaN											1	0	8.12818e-05	0.001984	8.48944e-05	6	28									
ACAT1	38	broad.mit.edu	37	11	108009666	108009666	+	Silent	SNP	T	T	C			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr11:108009666T>C	uc001pjy.2	+	6	553	c.477T>C	c.(475-477)GTT>GTC	p.V159V	ACAT1_uc001pjx.2_Silent_p.V33V	NM_000019	NP_000010	P24752	THIL_HUMAN	acetyl-Coenzyme A acetyltransferase 1 precursor	159					acetoacetic acid biosynthetic process|branched chain family amino acid catabolic process|ketone body biosynthetic process|ketone body catabolic process	mitochondrial matrix	acetyl-CoA C-acetyltransferase activity|metal ion binding			ovary(3)	3		all_cancers(61;6.41e-10)|all_epithelial(67;2.83e-06)|Melanoma(852;1.46e-05)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		BRCA - Breast invasive adenocarcinoma(274;2.96e-05)|Epithelial(105;4.35e-05)|all cancers(92;0.00108)|OV - Ovarian serous cystadenocarcinoma(223;0.192)	Sulfasalazine(DB00795)	TGTCCAATGTTCCATATGTAA	0.398		NaN											0	0	0	0.01441	0	54	171									
HINFP	25988	broad.mit.edu	37	11	118997680	118997680	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr11:118997680G>A	uc001pvp.2	+	3	215	c.26G>A	c.(25-27)CGA>CAA	p.R9Q	HINFP_uc010rzb.1_Missense_Mutation_p.R9Q|HINFP_uc001pvq.2_Missense_Mutation_p.R9Q	NM_015517	NP_056332	Q9BQA5	HINFP_HUMAN	MBD2 (methyl-CpG-binding protein)-interacting	9					DNA damage checkpoint|DNA repair|establishment of protein localization|in utero embryonic development|myoblast differentiation|negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|regulation of transcription involved in G1/S phase of mitotic cell cycle	Cajal body	enzyme binding|histone binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription regulatory region DNA binding|zinc ion binding			pancreas(2)|ovary(1)|skin(1)	4						AAAGTTCCCCGAAAGGAGAAT	0.537		NaN											0	0	0	0.01441	0	80	46									
KCNH3	23416	broad.mit.edu	37	12	49944089	49944089	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr12:49944089G>T	uc001ruh.1	+	10	2155	c.1895G>T	c.(1894-1896)GGT>GTT	p.G632V	KCNH3_uc010smj.1_Missense_Mutation_p.G572V	NM_012284	NP_036416	Q9ULD8	KCNH3_HUMAN	potassium voltage-gated channel, subfamily H	632	cNMP.|Cytoplasmic (Potential).				regulation of transcription, DNA-dependent	integral to membrane	two-component sensor activity|voltage-gated potassium channel activity				0						GTGCTCAAGGGTGGCACCGTG	0.632		NaN											1	0	6.12954e-19	0.004656	7.5023e-19	18	78									
GTSF1	121355	broad.mit.edu	37	12	54854248	54854248	+	Missense_Mutation	SNP	T	T	C			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr12:54854248T>C	uc001sgb.2	-	7	486	c.400A>G	c.(400-402)AGC>GGC	p.S134G		NM_144594	NP_653195	Q8WW33	GTSF1_HUMAN	gametocyte specific factor 1	134							metal ion binding				0		Myeloproliferative disorder(1001;0.00452)				ACTATGTTGCTCGCAGGGCTG	0.413		NaN											0	0	0	0.008871	0	18	27									
SILV	6490	broad.mit.edu	37	12	56355112	56355112	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr12:56355112G>T	uc001sip.2	-	3	354	c.323C>A	c.(322-324)ACC>AAC	p.T108N	SILV_uc001siq.2_Missense_Mutation_p.T108N|SILV_uc010spx.1_Intron|SILV_uc001sir.2_Missense_Mutation_p.T108N	NM_006928	NP_008859	P40967	PMEL_HUMAN	silver homolog	108					melanin biosynthetic process|melanosome organization	endoplasmic reticulum membrane|extracellular region|Golgi apparatus|integral to membrane|melanosome|multivesicular body membrane|plasma membrane	protein binding				0						ATTGATGATGGTATTGTTGAC	0.488		NaN											1	0	9.8876e-21	0.004878	1.23595e-20	32	19									
ERBB3	2065	broad.mit.edu	37	12	56481649	56481649	+	Missense_Mutation	SNP	T	T	A			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08			T	A	T	T		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq;WGS			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr12:56481649T>A	uc001sjh.2	+	6	877	c.684T>A	c.(682-684)CAT>CAA	p.H228Q	ERBB3_uc009zoj.2_RNA|ERBB3_uc010sqb.1_Intron|ERBB3_uc010sqc.1_Missense_Mutation_p.H169Q|ERBB3_uc001sji.2_5'Flank	NM_001982	NP_001973	P21860	ERBB3_HUMAN	erbB-3 isoform 1 precursor	228	Extracellular (Potential).				cranial nerve development|heart development|negative regulation of cell adhesion|negative regulation of neuron apoptosis|negative regulation of secretion|negative regulation of signal transduction|neuron apoptosis|phosphatidylinositol 3-kinase cascade|positive regulation of phosphatidylinositol 3-kinase cascade|regulation of cell proliferation|Schwann cell differentiation|transmembrane receptor protein tyrosine kinase signaling pathway|wound healing	basolateral plasma membrane|extracellular space|integral to plasma membrane|receptor complex	ATP binding|growth factor binding|protein heterodimerization activity|protein homodimerization activity|protein tyrosine kinase activator activity|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			lung(3)|central_nervous_system(2)|stomach(1)|ovary(1)|skin(1)	8			OV - Ovarian serous cystadenocarcinoma(18;0.112)			AGTGCTGCCATGATGAGTGTG	0.537		NaN											0	0	0	0.01441	0	52	121									
CEP290	80184	broad.mit.edu	37	12	88486515	88486515	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr12:88486515C>A	uc001tar.2	-	29	3748	c.3404G>T	c.(3403-3405)AGG>ATG	p.R1135M	CEP290_uc001taq.2_Missense_Mutation_p.R195M	NM_025114	NP_079390	O15078	CE290_HUMAN	centrosomal protein 290kDa	1135	Potential.				cilium assembly|eye photoreceptor cell development|G2/M transition of mitotic cell cycle|hindbrain development|otic vesicle formation|positive regulation of transcription, DNA-dependent|pronephros development|protein transport	cell surface|centrosome|cytosol|nucleus|photoreceptor connecting cilium	protein binding			ovary(5)|breast(1)|pancreas(1)	7						AATCCGTTGCCTATCAGCATC	0.368		NaN											1	0	1.16021e-09	0.007291	1.30454e-09	28	59									
SRRM4	84530	broad.mit.edu	37	12	119568521	119568521	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr12:119568521G>A	uc001txa.1	+	8	945	c.653G>A	c.(652-654)CGC>CAC	p.R218H		NM_194286	NP_919262	A7MD48	SRRM4_HUMAN	KIAA1853 protein	218	Ser-rich.				cell differentiation|mRNA processing|nervous system development|regulation of RNA splicing|RNA splicing	nucleus	mRNA binding			ovary(2)	2						CAGAAGTCCCGCCGAAGGCAC	0.652		NaN											0	0	0	0.008291	0	11	10									
TCTN2	79867	broad.mit.edu	37	12	124158196	124158196	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr12:124158196G>T	uc001ufp.2	+	4	430	c.302G>T	c.(301-303)GGT>GTT	p.G101V	TCTN2_uc009zya.2_Missense_Mutation_p.G100V	NM_024809	NP_079085	Q96GX1	TECT2_HUMAN	tectonic family member 2 isoform 1	101	Extracellular (Potential).				cilium assembly|smoothened signaling pathway	integral to membrane				ovary(1)	1	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000163)|Epithelial(86;0.000502)|all cancers(50;0.00451)		TGGAAGAGAGGTCTGGACTGG	0.433		NaN											1	0	2.48779e-11	0.005443	2.86584e-11	21	71									
TMEM132B	114795	broad.mit.edu	37	12	126135372	126135372	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr12:126135372G>T	uc001uhe.1	+	7	1780	c.1772G>T	c.(1771-1773)GGC>GTC	p.G591V	TMEM132B_uc001uhf.1_Missense_Mutation_p.G103V	NM_052907	NP_443139	Q14DG7	T132B_HUMAN	transmembrane protein 132B	591	Extracellular (Potential).					integral to membrane				skin(11)|ovary(5)|large_intestine(1)|pancreas(1)|breast(1)	19	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000423)|Epithelial(86;0.00394)|all cancers(50;0.0362)		TACATGCTGGGCCCCGACTGG	0.597		NaN											1	0	2.21704e-12	0.00278	2.57922e-12	18	53									
CDK8	1024	broad.mit.edu	37	13	26828866	26828866	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr13:26828866G>T	uc001uqr.1	+	1	114	c.88G>T	c.(88-90)GGC>TGC	p.G30C	CDK8_uc001uqs.1_Missense_Mutation_p.G30C|CDK8_uc001uqt.1_Translation_Start_Site	NM_001260	NP_001251	P49336	CDK8_HUMAN	cyclin-dependent kinase 8	30	Protein kinase.|ATP (By similarity).				regulation of transcription, DNA-dependent|transcription, DNA-dependent	mediator complex	ATP binding|cyclin-dependent protein kinase activity|protein binding|RNA polymerase II carboxy-terminal domain kinase activity			lung(2)|large_intestine(1)|ovary(1)|skin(1)	5	Colorectal(5;0.000442)	Lung SC(185;0.0156)|Breast(139;0.147)		all cancers(112;0.0384)|Epithelial(112;0.142)|OV - Ovarian serous cystadenocarcinoma(117;0.188)		AGTTGGCCGAGGCACTTATGG	0.592		NaN											1	0	5.3912e-06	0.006122	5.81162e-06	16	21									
N4BP2L2	10443	broad.mit.edu	37	13	33096357	33096357	+	Missense_Mutation	SNP	T	T	C			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr13:33096357T>C	uc001uuk.3	-	4	1613	c.1435A>G	c.(1435-1437)AAT>GAT	p.N479D	N4BP2L2_uc001uuj.2_5'UTR|N4BP2L2_uc010abe.1_Missense_Mutation_p.N50D|N4BP2L2_uc010tdz.1_Missense_Mutation_p.N35D	NM_014887	NP_055702	Q92802	N42L2_HUMAN	phosphonoformate immuno-associated protein 5	479											0		Lung SC(185;0.0262)		all cancers(112;9.5e-07)|Epithelial(112;5.07e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.00196)|BRCA - Breast invasive adenocarcinoma(63;0.00438)|GBM - Glioblastoma multiforme(144;0.243)		GCTTGTATATTAGTGTTATCT	0.254		NaN											0	0	0	0.01441	0	51	68									
RB1	5925	broad.mit.edu	37	13	48955538	48955538	+	Nonsense_Mutation	SNP	C	C	T	rs121913303		TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;WGS			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr13:48955538C>T	uc001vcb.2	+	17	1820	c.1654C>T	c.(1654-1656)CGA>TGA	p.R552*		NM_000321	NP_000312	P06400	RB_HUMAN	retinoblastoma 1	552	Domain A.|Pocket; binds T and E1A.				androgen receptor signaling pathway|cell cycle arrest|chromatin remodeling|G1 phase of mitotic cell cycle|interspecies interaction between organisms|maintenance of mitotic sister chromatid cohesion|mitotic cell cycle G1/S transition checkpoint|myoblast differentiation|negative regulation of cell growth|negative regulation of protein kinase activity|negative regulation of S phase of mitotic cell cycle|negative regulation of sequence-specific DNA binding transcription factor activity|positive regulation of mitotic metaphase/anaphase transition|protein localization to chromosome, centromeric region|Ras protein signal transduction|regulation of centromere complex assembly|regulation of cohesin localization to chromatin|regulation of lipid kinase activity|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle|sister chromatid biorientation	chromatin|PML body|Rb-E2F complex|SWI/SNF complex	androgen receptor binding|DNA binding|kinase binding|phosphoprotein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription factor binding|ubiquitin protein ligase binding	p.?(7)|p.R552*(5)		lung(94)|eye(89)|central_nervous_system(47)|bone(22)|breast(21)|urinary_tract(17)|haematopoietic_and_lymphoid_tissue(14)|ovary(10)|prostate(9)|soft_tissue(8)|skin(7)|endometrium(5)|cervix(3)|liver(3)|salivary_gland(2)|stomach(2)|oesophagus(1)|adrenal_gland(1)|kidney(1)|gastrointestinal_tract_(site_indeterminate)(1)|pituitary(1)	358		all_cancers(8;6.9e-71)|all_epithelial(8;4.61e-22)|Acute lymphoblastic leukemia(8;1.1e-21)|all_hematologic(8;2.3e-21)|all_lung(13;1.51e-09)|Lung NSC(96;7.03e-07)|Breast(56;1.53e-05)|Prostate(109;0.000493)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|all_neural(104;0.0227)|Glioma(44;0.0286)|Lung SC(185;0.0301)		GBM - Glioblastoma multiforme(2;9.98e-18)|LUSC - Lung squamous cell carcinoma(3;0.013)	Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	ACATTTAGAACGATGTGAACA	0.323	R552*(NCIH1048_LUNG)	6	D|Mis|N|F|S		retinoblastoma|sarcoma|breast|small cell lung	retinoblastoma|sarcoma|breast|small cell lung			Hereditary_Retinoblastoma	TCGA GBM(7;6.82e-08)|TSP Lung(12;0.097)|TCGA Ovarian(6;0.080)			0	0	0	0.00278	0	17	24									
KLHL1	57626	broad.mit.edu	37	13	70314576	70314576	+	Silent	SNP	G	G	A			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr13:70314576G>A	uc001vip.2	-	8	2546	c.1752C>T	c.(1750-1752)GCC>GCT	p.A584A	KLHL1_uc010thm.1_Silent_p.A523A	NM_020866	NP_065917	Q9NR64	KLHL1_HUMAN	kelch-like 1 protein	584	Kelch 3.				actin cytoskeleton organization	cytoplasm|cytoskeleton	actin binding				0		Breast(118;0.000162)		COAD - Colon adenocarcinoma(199;0.000193)|GBM - Glioblastoma multiforme(99;0.000211)		TTGACATACTGGCTACAAATG	0.403		NaN											0	0	0	0.006999	0	31	42									
GPC5	2262	broad.mit.edu	37	13	92560246	92560246	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr13:92560246G>A	uc010tif.1	+	6	1702	c.1336G>A	c.(1336-1338)GTC>ATC	p.V446I		NM_004466	NP_004457	P78333	GPC5_HUMAN	glypican 5 precursor	446						anchored to membrane|extracellular space|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding			ovary(2)|skin(2)|upper_aerodigestive_tract(1)	5	all_cancers(3;1.43e-07)|all_neural(89;0.0804)|Medulloblastoma(90;0.163)	Lung NSC(4;0.00454)				AAATCCTGAAGTCAAAGTCAA	0.378		NaN											0	0	0	0.007835	0	36	38									
FAM179B	23116	broad.mit.edu	37	14	45431955	45431955	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr14:45431955G>A	uc001wvv.2	+	1	540	c.331G>A	c.(331-333)GAG>AAG	p.E111K	FAM179B_uc001wvw.2_Missense_Mutation_p.E111K|FAM179B_uc010anc.2_RNA|KLHL28_uc001wvq.2_5'Flank|KLHL28_uc001wvr.2_5'Flank|FAM179B_uc010anb.1_Missense_Mutation_p.E111K|FAM179B_uc001wvu.2_Missense_Mutation_p.E111K	NM_015091	NP_055906	Q9Y4F4	F179B_HUMAN	hypothetical protein LOC23116	111							binding			skin(2)|upper_aerodigestive_tract(1)	3						GGATCCTTCTGAGGCCTTCCA	0.622		NaN											0	0	0	0.009535	0	24	71									
SYT16	83851	broad.mit.edu	37	14	62547819	62547819	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr14:62547819G>C	uc001xfu.1	+	4	1458	c.1261G>C	c.(1261-1263)GCC>CCC	p.A421P	SYT16_uc010tsd.1_3'UTR|SYT16_uc010tse.1_5'UTR	NM_031914	NP_114120	Q17RD7	SYT16_HUMAN	synaptotagmin XIV-like	421	C2 1.									central_nervous_system(1)	1				OV - Ovarian serous cystadenocarcinoma(108;0.0438)|BRCA - Breast invasive adenocarcinoma(234;0.118)		GGTCACCTTTGCCAAGCTGGA	0.567		NaN											0	0	0	0.004007	0	12	10									
KIAA1409	57578	broad.mit.edu	37	14	94004365	94004365	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr14:94004365G>C	uc001ybv.1	+	9	705	c.622G>C	c.(622-624)GTC>CTC	p.V208L	KIAA1409_uc001ybs.1_Missense_Mutation_p.V208L|KIAA1409_uc001ybu.1_Missense_Mutation_p.V146L	NM_020818	NP_065869	Q9P2D8	UNC79_HUMAN	hypothetical protein LOC57578	385						integral to membrane				ovary(10)|skin(4)|large_intestine(3)	17		all_cancers(154;0.0354)|all_epithelial(191;0.216)		Epithelial(152;0.188)		AAGAGCAGTTGTCACCTGCTT	0.468		NaN											0	0	0	0.004656	0	23	22									
SHC4	399694	broad.mit.edu	37	15	49118194	49118194	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr15:49118194G>C	uc001zxb.1	-	12	2296	c.1867C>G	c.(1867-1869)CCA>GCA	p.P623A	SHC4_uc010uey.1_Missense_Mutation_p.P380A|SHC4_uc010uez.1_Missense_Mutation_p.P337A	NM_203349	NP_976224	Q6S5L8	SHC4_HUMAN	rai-like protein	623					intracellular signal transduction	cell junction|postsynaptic membrane				ovary(3)|pancreas(2)	5		all_lung(180;0.00466)		all cancers(107;9.4e-08)|GBM - Glioblastoma multiforme(94;5.94e-07)		AAAAGTGCTGGATTATTATCT	0.373		NaN											0	0	0	0.01441	0	47	127									
PSTPIP1	9051	broad.mit.edu	37	15	77323595	77323595	+	Silent	SNP	C	C	T			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr15:77323595C>T	uc002bcf.2	+	10	1167	c.717C>T	c.(715-717)TCC>TCT	p.S239S	PSTPIP1_uc010bkt.1_RNA|PSTPIP1_uc010umo.1_Silent_p.S117S|PSTPIP1_uc010bku.1_Silent_p.S230S|PSTPIP1_uc002bcg.2_Silent_p.S239S|PSTPIP1_uc010bkw.1_Silent_p.S239S|PSTPIP1_uc002bch.1_5'UTR|PSTPIP1_uc002bci.1_5'Flank	NM_003978	NP_003969	O43586	PPIP1_HUMAN	proline-serine-threonine phosphatase interacting	239					cell adhesion|signal transduction	cleavage furrow|lamellipodium|perinuclear region of cytoplasm	catalytic activity			ovary(1)	1						ACCAGCTCTCCATGCAGTGTG	0.617		NaN											0	0	0	0.01441	0	65	100									
LRRK1	79705	broad.mit.edu	37	15	101595287	101595287	+	Silent	SNP	T	T	A			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr15:101595287T>A	uc002bwr.2	+	27	4510	c.4191T>A	c.(4189-4191)CTT>CTA	p.L1397L	LRRK1_uc010usb.1_RNA|LRRK1_uc010usc.1_RNA|LRRK1_uc002bws.2_RNA	NM_024652	NP_078928	Q38SD2	LRRK1_HUMAN	leucine-rich repeat kinase 1	1397	Protein kinase.				small GTPase mediated signal transduction	mitochondrion	ATP binding|GTP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			ovary(4)|lung(4)|central_nervous_system(3)|large_intestine(1)	12	Melanoma(26;0.00505)|Lung NSC(78;0.00793)|all_lung(78;0.0094)		OV - Ovarian serous cystadenocarcinoma(32;0.000932)|LUSC - Lung squamous cell carcinoma(107;0.187)|Lung(145;0.23)			TGTGGTCCCTTGACGTCAAGG	0.532		NaN											0	0	0	0.007291	0	22	59									
ZNF205	7755	broad.mit.edu	37	16	3168975	3168975	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr16:3168975G>T	uc002cub.2	+	6	689	c.554G>T	c.(553-555)CGG>CTG	p.R185L	ZNF205_uc002cua.2_Missense_Mutation_p.R185L	NM_001042428	NP_001035893	O95201	ZN205_HUMAN	zinc finger protein 205	185	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding				0						GGCTCCAGCCGGCAGGCAGGA	0.667		NaN											1	0	3.09479e-21	0.006999	3.91008e-21	31	62									
ANKS3	124401	broad.mit.edu	37	16	4764077	4764077	+	Silent	SNP	C	C	G			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr16:4764077C>G	uc002cxj.1	-	7	979	c.684G>C	c.(682-684)CTG>CTC	p.L228L	ANKS3_uc002cxi.1_Silent_p.L155L|ANKS3_uc002cxk.2_Silent_p.L99L|ANKS3_uc002cxl.2_Silent_p.L55L|ANKS3_uc010uxs.1_Silent_p.L155L|ANKS3_uc002cxm.2_Silent_p.L22L	NM_133450	NP_597707	Q6ZW76	ANKS3_HUMAN	ankyrin repeat and sterile alpha motif domain	228											0						GGCTCTTGGGCAGAGAGGGCG	0.607		NaN											0	0	0	0.007413	0	18	36									
RBBP6	5930	broad.mit.edu	37	16	24582981	24582981	+	Missense_Mutation	SNP	A	A	G			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr16:24582981A>G	uc002dmh.2	+	18	5634	c.4594A>G	c.(4594-4596)AGT>GGT	p.S1532G	RBBP6_uc002dmi.2_Missense_Mutation_p.S1498G|RBBP6_uc010bxr.2_Missense_Mutation_p.S692G|RBBP6_uc002dmk.2_Missense_Mutation_p.S1365G	NM_006910	NP_008841	Q7Z6E9	RBBP6_HUMAN	retinoblastoma-binding protein 6 isoform 1	1532	Interaction with p53 (By similarity).				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	chromosome|nucleolus|ubiquitin ligase complex	nucleic acid binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(3)|pancreas(1)	4				GBM - Glioblastoma multiforme(48;0.0518)		TTCCAAAAAAAGTAATTCTAG	0.373		NaN											0	0	0	0.009096	0	3	14									
ATXN2L	11273	broad.mit.edu	37	16	28834730	28834730	+	Silent	SNP	G	G	T			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr16:28834730G>T	uc002drc.2	+	1	318	c.150G>T	c.(148-150)GGG>GGT	p.G50G	uc010vct.1_Intron|ATXN2L_uc010byl.1_Silent_p.G50G|ATXN2L_uc002drb.2_Silent_p.G50G|ATXN2L_uc002dqy.2_Silent_p.G50G|ATXN2L_uc002dra.2_Silent_p.G50G|ATXN2L_uc002dqz.2_Silent_p.G50G|ATXN2L_uc010vdb.1_Silent_p.G50G|ATXN2L_uc002dre.2_Silent_p.G50G	NM_007245	NP_009176	Q8WWM7	ATX2L_HUMAN	ataxin 2 related protein isoform A	50	Pro-rich.					membrane				upper_aerodigestive_tract(1)|ovary(1)	2						CTCCTCCCGGGCCTCCAGCGG	0.821		NaN											1	0	0.00909568	0.009096	0.00925318	2	2									
CPNE2	221184	broad.mit.edu	37	16	57157339	57157339	+	Missense_Mutation	SNP	A	A	G			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr16:57157339A>G	uc002eks.1	+	10	1110	c.881A>G	c.(880-882)TAC>TGC	p.Y294C	CPNE2_uc010cct.1_Missense_Mutation_p.Y320C|CPNE2_uc010ccu.1_Missense_Mutation_p.Y294C|CPNE2_uc002ekt.1_5'Flank	NM_152727	NP_689940	Q96FN4	CPNE2_HUMAN	copine II	294										central_nervous_system(1)|skin(1)	2		all_neural(199;0.224)				AACCGAGACTACTCCTTCCTT	0.498		NaN											0	0	0	0.01441	0	63	72									
CES2	8824	broad.mit.edu	37	16	66969416	66969416	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr16:66969416C>G	uc002eqr.2	+	1	1070	c.70C>G	c.(70-72)CCC>GCC	p.P24A	CES2_uc002eqq.2_Missense_Mutation_p.P24A|CES2_uc002eqs.2_5'UTR|FAM96B_uc002eqp.2_5'Flank	NM_003869	NP_003860	O00748	EST2_HUMAN	carboxylesterase 2 isoform 1	Error:Variant_position_missing_in_O00748_after_alignment					catabolic process	endoplasmic reticulum lumen	carboxylesterase activity|methyl indole-3-acetate esterase activity|methyl jasmonate esterase activity|methyl salicylate esterase activity				0		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0663)|Epithelial(162;0.166)		CCCGCTGACTCCCTGCCCAGT	0.662		NaN											0	0	0	0.01441	0	46	165									
ATMIN	23300	broad.mit.edu	37	16	81076953	81076953	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr16:81076953C>G	uc002ffz.1	+	4	868	c.850C>G	c.(850-852)CTT>GTT	p.L284V	ATMIN_uc002fga.2_Missense_Mutation_p.L126V|ATMIN_uc010vnn.1_Missense_Mutation_p.L55V|ATMIN_uc002fgb.1_Missense_Mutation_p.L126V	NM_015251	NP_056066	O43313	ATMIN_HUMAN	ATM interactor	284	Required for formation of RAD51 foci.				response to DNA damage stimulus	nucleus	zinc ion binding				0						CAAGCAGACTCTTACAACACC	0.433		NaN											0	0	0	0.003271	0	33	59									
CDH13	1012	broad.mit.edu	37	16	82891976	82891976	+	Silent	SNP	C	C	T			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr16:82891976C>T	uc002fgx.2	+	2	175	c.55C>T	c.(55-57)CTA>TTA	p.L19L	CDH13_uc010chh.2_Silent_p.L19L|CDH13_uc010vns.1_Silent_p.L66L|CDH13_uc010vnt.1_5'UTR|CDH13_uc010vnu.1_Silent_p.L19L	NM_001257	NP_001248	P55290	CAD13_HUMAN	cadherin 13 preproprotein	19					adherens junction organization|calcium-dependent cell-cell adhesion|cell junction assembly|endothelial cell migration|homophilic cell adhesion|keratinocyte proliferation|lamellipodium assembly|localization within membrane|low-density lipoprotein particle mediated signaling|negative regulation of cell adhesion|negative regulation of cell proliferation|positive regulation of calcium-mediated signaling|positive regulation of cell migration|positive regulation of cell-matrix adhesion|positive regulation of endothelial cell proliferation|positive regulation of positive chemotaxis|positive regulation of smooth muscle cell proliferation|positive regulation of survival gene product expression|Rac protein signal transduction|regulation of endocytosis|regulation of epidermal growth factor receptor signaling pathway|Rho protein signal transduction|sprouting angiogenesis	anchored to membrane|caveola|extracellular space|integral to membrane|neuron projection	adiponectin binding|cadherin binding|calcium ion binding|low-density lipoprotein particle binding			large_intestine(1)	1		all_cancers(2;1.34e-11)|all_epithelial(2;4.3e-09)		COAD - Colon adenocarcinoma(5;0.0268)		GGTGCTGCTGCTAACATCTGC	0.418		NaN											0	0	0	0.004878	0	35	28									
BANP	54971	broad.mit.edu	37	16	88008777	88008777	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr16:88008777G>C	uc002fkr.2	+	2	277	c.53G>C	c.(52-54)AGC>ACC	p.S18T	BANP_uc002fkp.2_Missense_Mutation_p.S19T|BANP_uc002fkq.2_Missense_Mutation_p.S19T|BANP_uc010vow.1_Missense_Mutation_p.S18T|BANP_uc002fks.3_Missense_Mutation_p.S18T|BANP_uc002fko.1_Intron|BANP_uc010vov.1_Missense_Mutation_p.S18T	NM_079837	NP_524576	Q8N9N5	BANP_HUMAN	BTG3 associated nuclear protein isoform b	19					cell cycle|chromatin modification|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding				0				BRCA - Breast invasive adenocarcinoma(80;0.00551)		GAAGACCTGAGCCCTGACCAC	0.473		NaN											0	0	0	0.003271	0	26	50									
TP53	7157	broad.mit.edu	37	17	7577538	7577538	+	Missense_Mutation	SNP	C	C	T	rs11540652		TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq;WGS			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr17:7577538C>T	uc002gim.2	-	7	937	c.743G>A	c.(742-744)CGG>CAG	p.R248Q	TP53_uc002gig.1_Missense_Mutation_p.R248Q|TP53_uc002gih.2_Missense_Mutation_p.R248Q|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.R116Q|TP53_uc010cng.1_Missense_Mutation_p.R116Q|TP53_uc002gii.1_Missense_Mutation_p.R116Q|TP53_uc010cnh.1_Missense_Mutation_p.R248Q|TP53_uc010cni.1_Missense_Mutation_p.R248Q|TP53_uc002gij.2_Missense_Mutation_p.R248Q|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.R155Q|TP53_uc002gio.2_Missense_Mutation_p.R116Q	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	248	|Interaction with HIPK1 (By similarity).|Interacts with the 53BP2 SH3 domain.|Interaction with AXIN1 (By similarity).		R -> W (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> P (in sporadic cancers; somatic mutation).|R -> G (in sporadic cancers; somatic mutation).|R -> L (in sporadic cancers; somatic mutation).|NR -> KW (in sporadic cancers; somatic mutation).|R -> C (in a sporadic cancer; somatic mutation).|NR -> IP (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R248Q(523)|p.R248W(443)|p.R248L(63)|p.R248P(12)|p.R248G(11)|p.R248R(10)|p.0?(7)|p.R155Q(4)|p.N247_R248delNR(2)|p.N247_R248>KW(2)|p.M246_P250delMNRRP(2)|p.R248fs*97(2)|p.R248_P250delRRP(1)|p.N247_R249delNRR(1)|p.N247_P250delNRRP(1)|p.R249fs*96(1)|p.R248C(1)|p.G245fs*14(1)|p.N247_R248>IP(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GATGGGCCTCCGGTTCATGCC	0.572	R248Q(KASUMI1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(HS683_CENTRAL_NERVOUS_SYSTEM)|R248Q(NAMALWA_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(HCC1143_BREAST)|R248Q(BL41_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(SKUT1_SOFT_TISSUE)|R248Q(HSC4_UPPER_AERODIGESTIVE_TRACT)|R248Q(HEC1A_ENDOMETRIUM)|R248Q(SF295_CENTRAL_NERVOUS_SYSTEM)|R248Q(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(NUDHL1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(WSUDLCL2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(NCIN87_STOMACH)|R248Q(P12ICHIKAWA_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(DB_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(RT112_URINARY_TRACT)|R248Q(PF382_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(PANC0203_PANCREAS)|R248Q(EM2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(SEM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(CI1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(MOLM6_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(NIHOVCAR3_OVARY)|R248Q(CA46_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(SUPT1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(SW1463_LARGE_INTESTINE)|R248Q(HCC70_BREAST)|R248Q(KYSE150_OESOPHAGUS)|R248Q(NB4_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(NCIH211_LUNG)|R248Q(KYO1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(PC14_LUNG)	111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			0	0	0	0.006999	0	34	17									
CHD3	1107	broad.mit.edu	37	17	7802505	7802505	+	Silent	SNP	C	C	T			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr17:7802505C>T	uc002gje.2	+	14	2478	c.2328C>T	c.(2326-2328)TAC>TAT	p.Y776Y	CHD3_uc002gjd.2_Silent_p.Y835Y|CHD3_uc002gjf.2_Silent_p.Y776Y	NM_001005273	NP_001005273	Q12873	CHD3_HUMAN	chromodomain helicase DNA binding protein 3	776	Helicase ATP-binding.				chromatin modification|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	microtubule organizing center|NuRD complex	ATP binding|ATP-dependent DNA helicase activity|DNA binding|protein binding|zinc ion binding			breast(1)	1		Prostate(122;0.202)				TCTTCCTCTACTCACTCTACA	0.567		NaN											0	0	0	0.01441	0	58	18									
C17orf48	56985	broad.mit.edu	37	17	10608309	10608309	+	Silent	SNP	C	C	T			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr17:10608309C>T	uc002gmt.2	+	2	141	c.66C>T	c.(64-66)GTC>GTT	p.V22V	C17orf48_uc002gmu.2_RNA|C17orf48_uc002gmv.2_RNA|C17orf48_uc010vvg.1_Silent_p.V22V	NM_020233	NP_064618	Q3LIE5	ADPRM_HUMAN	ADP-ribose/CDP-alcohol pyrophosphatase	22							ADP-ribose diphosphatase activity|CDP-glycerol diphosphatase activity|metal ion binding				0						CCTTTGGCGTCATCGCAGATG	0.423		NaN											0	0	0	0.004482	0	8	48									
SSH2	85464	broad.mit.edu	37	17	27959241	27959241	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr17:27959241G>T	uc002heo.1	-	15	2890	c.2890C>A	c.(2890-2892)CAC>AAC	p.H964N	SSH2_uc010wbh.1_Missense_Mutation_p.H991N	NM_033389	NP_203747	Q76I76	SSH2_HUMAN	slingshot 2	964					actin cytoskeleton organization|regulation of actin polymerization or depolymerization|regulation of axonogenesis|regulation of lamellipodium assembly	cytoplasm|cytoskeleton	actin binding|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			skin(2)	2						TCTGGCAAGTGGTCAAACTCC	0.547		NaN											1	0	1.64293e-13	0.00333	1.94015e-13	23	19									
LRRC37B	114659	broad.mit.edu	37	17	30348423	30348423	+	Silent	SNP	G	G	C			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr17:30348423G>C	uc002hgu.2	+	1	269	c.258G>C	c.(256-258)CTG>CTC	p.L86L	LRRC37B_uc010wbx.1_Silent_p.L4L|LRRC37B_uc010csu.2_Silent_p.L86L	NM_052888	NP_443120	Q96QE4	LR37B_HUMAN	leucine rich repeat containing 37B precursor	86	Extracellular (Potential).					integral to membrane				upper_aerodigestive_tract(1)|ovary(1)	2		Myeloproliferative disorder(56;0.0255)|all_hematologic(16;0.111)|Ovarian(249;0.182)|Breast(31;0.244)				TGTCAGCCCTGCCTCAGGAAC	0.592		NaN											0	0	0	0.004007	0	16	57									
AMAC1	146861	broad.mit.edu	37	17	33520917	33520917	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr17:33520917G>T	uc002hjd.2	-	1	496	c.410C>A	c.(409-411)TCT>TAT	p.S137Y		NM_152462	NP_689675	Q8N808	AMAC1_HUMAN	acyl-malonyl condensing enzyme 1	137	DUF6 1.					integral to membrane					0				BRCA - Breast invasive adenocarcinoma(366;0.0917)		GACGGTGGAAGAACCTTTGCG	0.587		NaN											1	0	1.48734e-19	0.013114	1.82997e-19	32	136									
MAP3K14	9020	broad.mit.edu	37	17	43351496	43351496	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr17:43351496C>G	uc002iiw.1	-	9	1655	c.1546G>C	c.(1546-1548)GTC>CTC	p.V516L	MAP3K14_uc002iiu.1_5'Flank|MAP3K14_uc010daj.1_RNA|MAP3K14_uc002iiv.1_Missense_Mutation_p.V100L	NM_003954	NP_003945	Q99558	M3K14_HUMAN	mitogen-activated protein kinase kinase kinase	516	Interaction with ZFP91.|Protein kinase.				cellular response to mechanical stimulus|I-kappaB kinase/NF-kappaB cascade|immune response|positive regulation of I-kappaB kinase/NF-kappaB cascade|T cell costimulation	cytosol	ATP binding|MAP kinase kinase kinase activity|NF-kappaB-inducing kinase activity|protein binding			central_nervous_system(3)|breast(2)|lung(1)|ovary(1)|stomach(1)	8						TTACCTTTGACGTCCCCATGC	0.617		NaN											0	0	0	0.009096	0	3	3									
ATP5G1	516	broad.mit.edu	37	17	46971758	46971758	+	Missense_Mutation	SNP	A	A	G			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr17:46971758A>G	uc002iog.2	+	3	198	c.64A>G	c.(64-66)ATC>GTC	p.I22V	ATP5G1_uc002ioh.2_Missense_Mutation_p.I22V	NM_005175	NP_005166	P05496	AT5G1_HUMAN	ATP synthase, H+ transporting, mitochondrial F0	22					ATP hydrolysis coupled proton transport|mitochondrial ATP synthesis coupled proton transport|respiratory electron transport chain	integral to membrane|mitochondrial proton-transporting ATP synthase complex|proton-transporting ATP synthase complex, coupling factor F(o)	hydrogen ion transmembrane transporter activity|lipid binding				0						CAGGGGTCTAATCAGGCCTGT	0.438		NaN											0	0	0	0.01441	0	50	125									
MFSD11	79157	broad.mit.edu	37	17	74740413	74740413	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr17:74740413G>C	uc002jta.2	+	8	1479	c.506G>C	c.(505-507)CGA>CCA	p.R169P	MFSD11_uc002jtb.2_Missense_Mutation_p.R169P|MFSD11_uc010dha.2_Missense_Mutation_p.R117P|MFSD11_uc002jtc.2_Missense_Mutation_p.R169P|MFSD11_uc002jtd.3_Missense_Mutation_p.R169P|MFSD11_uc010dhb.2_Missense_Mutation_p.R117P|MFSD11_uc002jte.2_Missense_Mutation_p.R169P	NM_024311	NP_077287	O43934	MFS11_HUMAN	major facilitator superfamily domain containing	169						integral to membrane				ovary(1)	1						GAGAGTGACCGAAGAACAGTG	0.413		NaN											0	0	0	0.004289	0	25	48									
TSPAN10	83882	broad.mit.edu	37	17	79612041	79612041	+	Silent	SNP	C	C	T			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr17:79612041C>T	uc010die.2	+	2	150	c.60C>T	c.(58-60)CTC>CTT	p.L20L	TSPAN10_uc002kaw.1_Silent_p.L20L|TSPAN10_uc010did.1_RNA	NM_031945	NP_114151	Q9H1Z9	TSN10_HUMAN	tetraspanin 10	20						integral to membrane				ovary(1)	1	all_neural(118;0.0878)|all_lung(278;0.175)|Lung NSC(278;0.192)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0101)|OV - Ovarian serous cystadenocarcinoma(97;0.0739)			AGAAGCCCCTCTCTGTGCACA	0.647		NaN											0	0	0	0.013537	0	10	28									
NDC80	10403	broad.mit.edu	37	18	2575029	2575029	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr18:2575029C>T	uc002kli.2	+	3	325	c.143C>T	c.(142-144)CCG>CTG	p.P48L		NM_006101	NP_006092	O14777	NDC80_HUMAN	kinetochore associated 2	48	Interaction with the N-terminus of CDCA1.|Nuclear localization.				attachment of spindle microtubules to kinetochore|cell division|establishment of mitotic spindle orientation|mitotic prometaphase|mitotic sister chromatid segregation|mitotic spindle organization|phosphatidylinositol-mediated signaling	condensed nuclear chromosome outer kinetochore|cytosol|Ndc80 complex	protein binding			ovary(1)	1						ATAAACAAACCGACATCTGAA	0.303		NaN											0	0	0	0.004007	0	10	12									
RNF152	220441	broad.mit.edu	37	18	59483323	59483323	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr18:59483323C>G	uc002lih.1	-	2	786	c.374G>C	c.(373-375)AGC>ACC	p.S125T		NM_173557	NP_775828	Q8N8N0	RN152_HUMAN	ring finger protein 152	125					apoptosis|protein K48-linked ubiquitination	integral to membrane|lysosomal membrane	ubiquitin-protein ligase activity|zinc ion binding			breast(1)	1		Colorectal(73;0.186)				CTTCTGCTGGCTCCCGGGCAG	0.662		NaN											0	0	0	0.00333	0	19	7									
MLLT1	4298	broad.mit.edu	37	19	6230639	6230639	+	Missense_Mutation	SNP	T	T	C			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr19:6230639T>C	uc002mek.2	-	4	526	c.362A>G	c.(361-363)AAG>AGG	p.K121R		NM_005934	NP_005925	Q03111	ENL_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	121					regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|nucleolus	DNA binding|protein binding			skin(1)	1						GAAGGTGAGCTTCTCGCAGCG	0.647		NaN	T	MLL	AL								0	0	0	0.01441	0	83	31									
CNN1	1264	broad.mit.edu	37	19	11660487	11660487	+	Silent	SNP	C	C	A			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr19:11660487C>A	uc002msc.1	+	7	935	c.771C>A	c.(769-771)GGC>GGA	p.G257G	CNN1_uc010xmb.1_Silent_p.G207G|CNN1_uc010xmc.1_Silent_p.G207G	NM_001299	NP_001290	P51911	CNN1_HUMAN	calponin 1, basic, smooth muscle	257	Calponin-like 3.				actomyosin structure organization|regulation of smooth muscle contraction	cytoskeleton	actin binding|calmodulin binding				0						CGCAGCGGGGCATGACGGTGT	0.652		NaN											1	0	7.76418e-22	0.005443	9.91621e-22	28	9									
MED26	9441	broad.mit.edu	37	19	16686879	16686879	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr19:16686879C>T	uc002nen.1	-	3	2023	c.1762G>A	c.(1762-1764)GAC>AAC	p.D588N	MED26_uc002nee.2_Intron	NM_004831	NP_004822	O95402	MED26_HUMAN	mediator complex subunit 26	588					regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	DNA binding|RNA polymerase II transcription cofactor activity|transcription coactivator activity			ovary(2)	2						AAGCGCCCGTCGTCGCCGTGC	0.537		NaN											0	0	0	0.01441	0	45	6									
GMIP	51291	broad.mit.edu	37	19	19740837	19740837	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr19:19740837C>T	uc002nnd.2	-	21	2965	c.2848G>A	c.(2848-2850)GAG>AAG	p.E950K	LPAR2_uc002nnb.3_5'Flank|LPAR2_uc002nna.3_5'Flank|LPAR2_uc002nnc.3_5'Flank|GMIP_uc010xrb.1_Missense_Mutation_p.E924K|GMIP_uc010xrc.1_Missense_Mutation_p.E921K	NM_016573	NP_057657	Q9P107	GMIP_HUMAN	GEM interacting protein	950					negative regulation of Rho GTPase activity|small GTPase mediated signal transduction	cytosol	metal ion binding|protein binding|Rho GTPase activator activity			ovary(1)	1						GGCACAGCCTCGCTGTCCAAT	0.637		NaN											0	0	0	0.004672	0	2	1									
ZNF536	9745	broad.mit.edu	37	19	31039827	31039827	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr19:31039827G>A	uc002nsu.1	+	4	3439	c.3301G>A	c.(3301-3303)GAC>AAC	p.D1101N	ZNF536_uc010edd.1_Missense_Mutation_p.D1101N	NM_014717	NP_055532	O15090	ZN536_HUMAN	zinc finger protein 536	1101					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(7)|large_intestine(2)|skin(2)	11	Esophageal squamous(110;0.0834)					CGGCCACGTGGACCCTGCATT	0.542		NaN											0	0	0	0.004656	0	21	41									
ZNF302	55900	broad.mit.edu	37	19	35175840	35175840	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr19:35175840C>G	uc002nvr.1	+	6	1293	c.1030C>G	c.(1030-1032)CTC>GTC	p.L344V	ZNF302_uc002nvp.1_Missense_Mutation_p.L300V|ZNF302_uc002nvq.1_Missense_Mutation_p.L300V|ZNF302_uc002nvs.1_Missense_Mutation_p.L300V	NM_018443	NP_060913	Q9NR11	ZN302_HUMAN	zinc finger protein 302	379	C2H2-type 4.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_lung(56;6.16e-07)|Lung NSC(56;9.71e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0849)			TGTGTCCCTTCTCATTCAGCA	0.423		NaN											0	0	0	0.00245	0	12	50									
ZNF420	147923	broad.mit.edu	37	19	37619520	37619520	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr19:37619520G>A	uc002ofl.2	+	5	1842	c.1627G>A	c.(1627-1629)GGC>AGC	p.G543S		NM_144689	NP_653290	Q8TAQ5	ZN420_HUMAN	zinc finger protein 420	543	C2H2-type 15.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			CTTTGCGCGTGGCTTACTACT	0.413		NaN											0	0	0	0.00632	0	28	54									
PLEKHG2	64857	broad.mit.edu	37	19	39913486	39913486	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr19:39913486G>A	uc010xuz.1	+	18	2117	c.1792G>A	c.(1792-1794)GAA>AAA	p.E598K	PLEKHG2_uc010xuy.1_Missense_Mutation_p.E539K|PLEKHG2_uc002olj.2_Intron|PLEKHG2_uc010xva.1_Missense_Mutation_p.E376K	NM_022835	NP_073746	Q9H7P9	PKHG2_HUMAN	common-site lymphoma/leukemia guanine nucleotide	598	Poly-Glu.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity			skin(2)|pancreas(1)|breast(1)	4	all_cancers(60;3.08e-07)|all_lung(34;2.66e-08)|Lung NSC(34;3e-08)|all_epithelial(25;6.57e-07)|Ovarian(47;0.0569)		Epithelial(26;2.92e-26)|all cancers(26;2.01e-23)|Lung(45;0.000499)|LUSC - Lung squamous cell carcinoma(53;0.000657)			GGAGGAGGAGGAAGAGGAAGG	0.602		NaN											0	0	0	0.000602	0	5	12									
ZNF780A	284323	broad.mit.edu	37	19	40580973	40580973	+	Missense_Mutation	SNP	T	T	C			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr19:40580973T>C	uc002omy.2	-	6	1601	c.1376A>G	c.(1375-1377)CAA>CGA	p.Q459R	ZNF780A_uc002omw.3_Intron|ZNF780A_uc002omz.2_Missense_Mutation_p.Q459R|ZNF780A_uc010xvh.1_Missense_Mutation_p.Q460R	NM_001010880	NP_001010880	O75290	Z780A_HUMAN	zinc finger protein 780A isoform b	459	C2H2-type 11.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_cancers(60;9.55e-06)|all_lung(34;1.17e-07)|Lung NSC(34;1.41e-07)|Ovarian(47;0.0925)					TTCAATAAGTTGGCAATGATA	0.403		NaN											0	0	0	0.01441	0	68	104									
PLD3	23646	broad.mit.edu	37	19	40882622	40882622	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr19:40882622G>C	uc002onm.3	+	11	1524	c.1126G>C	c.(1126-1128)GCC>CCC	p.A376P	PLD3_uc002onj.3_Missense_Mutation_p.A376P|PLD3_uc002onk.3_Missense_Mutation_p.A376P|PLD3_uc002onl.3_Missense_Mutation_p.A376P|PLD3_uc002onn.2_Missense_Mutation_p.A376P	NM_001031696	NP_001026866	Q8IV08	PLD3_HUMAN	phospholipase D3	376	Lumenal (Potential).				lipid catabolic process	endoplasmic reticulum membrane|integral to membrane	NAPE-specific phospholipase D activity|phospholipase D activity|protein binding			skin(2)|ovary(1)	3			Lung(22;0.000636)|LUSC - Lung squamous cell carcinoma(20;0.00248)			ATCCATGCGGGCCTTCCTGCT	0.652		NaN											0	0	0	0.01441	0	43	53									
LIPE	3991	broad.mit.edu	37	19	42911490	42911490	+	Missense_Mutation	SNP	T	T	A			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr19:42911490T>A	uc002otr.2	-	6	2250	c.1973A>T	c.(1972-1974)CAG>CTG	p.Q658L	uc010eif.1_Intron	NM_005357	NP_005348	Q05469	LIPS_HUMAN	hormone-sensitive lipase	658					cholesterol metabolic process|protein phosphorylation|triglyceride catabolic process	caveola|cytosol	hormone-sensitive lipase activity|protein binding			ovary(1)|breast(1)	2		Prostate(69;0.00682)				TCTGGAGGTCTGGGCCACAAA	0.687		NaN											0	0	0	0.001984	0	6	5									
KCNN4	3783	broad.mit.edu	37	19	44284956	44284956	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr19:44284956C>T	uc002oxl.2	-	1	454	c.58G>A	c.(58-60)GAG>AAG	p.E20K	KCNN4_uc010eja.1_RNA	NM_002250	NP_002241	O15554	KCNN4_HUMAN	intermediate conductance calcium-activated	20					defense response	voltage-gated potassium channel complex	calcium-activated potassium channel activity|calmodulin binding			ovary(2)	2		Prostate(69;0.0352)			Clotrimazole(DB00257)|Halothane(DB01159)|Quinine(DB00468)	TTCTCCTGCTCCAGCAAGCGC	0.662		NaN											0	0	0	0.01441	0	53	83									
DHX34	9704	broad.mit.edu	37	19	47876898	47876898	+	Missense_Mutation	SNP	C	C	T	rs141177029	byFrequency	TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr19:47876898C>T	uc010xyn.1	+	9	2346	c.2005C>T	c.(2005-2007)CGC>TGC	p.R669C		NM_014681	NP_055496	Q14147	DHX34_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 34	669						intracellular	ATP binding|ATP-dependent helicase activity|RNA binding|zinc ion binding			ovary(4)|upper_aerodigestive_tract(1)	5		all_cancers(25;1.65e-09)|all_epithelial(76;9.95e-08)|all_lung(116;7.27e-07)|Lung NSC(112;1.6e-06)|Ovarian(192;0.0139)|all_neural(266;0.026)|Breast(70;0.0503)		all cancers(93;7.16e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.000489)|GBM - Glioblastoma multiforme(486;0.00413)|Epithelial(262;0.0132)		GTGGTGCCGCCGCCGGGGCAT	0.657		NaN											0	0	0	0.003954	0	17	30									
MYBPC2	4606	broad.mit.edu	37	19	50961863	50961863	+	Silent	SNP	C	C	G			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr19:50961863C>G	uc002psf.2	+	21	2409	c.2358C>G	c.(2356-2358)GCC>GCG	p.A786A		NM_004533	NP_004524	Q14324	MYPC2_HUMAN	myosin binding protein C, fast type	786	Fibronectin type-III 2.				cell adhesion|muscle filament sliding	cytosol|myosin filament	actin binding|structural constituent of muscle			breast(1)	1		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.0079)|GBM - Glioblastoma multiforme(134;0.0144)		GGGTCCCTGCCAACACCGAGC	0.657		NaN											0	0	0	0.00499	0	14	34									
BIRC8	112401	broad.mit.edu	37	19	53793189	53793189	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr19:53793189C>G	uc002qbk.2	-	1	1687	c.439G>C	c.(439-441)GAG>CAG	p.E147Q		NM_033341	NP_203127	Q96P09	BIRC8_HUMAN	baculoviral IAP repeat-containing 8	147					apoptosis		zinc ion binding			lung(1)	1				GBM - Glioblastoma multiforme(134;0.00304)		ACAAGAACCTCAAGCGTTTTA	0.398		NaN											0	0	0	0.004289	0	31	70									
ZNF331	55422	broad.mit.edu	37	19	54080062	54080062	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr19:54080062G>T	uc002qbx.1	+	7	1682	c.248G>T	c.(247-249)TGG>TTG	p.W83L	ZNF331_uc002qby.1_Missense_Mutation_p.W83L|ZNF331_uc002qbz.1_Missense_Mutation_p.W83L|ZNF331_uc002qca.1_Missense_Mutation_p.W83L|ZNF331_uc010eqr.1_Missense_Mutation_p.W83L|ZNF331_uc002qcb.1_Missense_Mutation_p.W83L|ZNF331_uc002qcc.1_Missense_Mutation_p.W83L|ZNF331_uc002qcd.1_Missense_Mutation_p.W83L	NM_018555	NP_061025	Q9NQX6	ZN331_HUMAN	zinc finger protein 331	83					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(3)|upper_aerodigestive_tract(1)|ovary(1)|lung(1)	6				GBM - Glioblastoma multiforme(134;0.00555)		GGCCGTAACTGGATATGTGAA	0.398		NaN	T	NaN	follicular thyroid adenoma								1	0	3.86212e-05	0.008291	4.05178e-05	10	51									
LILRB1	10859	broad.mit.edu	37	19	55148021	55148021	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr19:55148021C>T	uc002qgj.2	+	15	2064	c.1724C>T	c.(1723-1725)GCC>GTC	p.A575V	LILRB1_uc010erp.1_3'UTR|LILRB1_uc002qgl.2_Missense_Mutation_p.A576V|LILRB1_uc002qgk.2_Missense_Mutation_p.A576V|LILRB1_uc002qgm.2_Missense_Mutation_p.A577V|LILRB1_uc010erq.2_Missense_Mutation_p.A559V|LILRB1_uc010err.2_RNA	NM_006669	NP_006660	Q8NHL6	LIRB1_HUMAN	leukocyte immunoglobulin-like receptor,	575	Cytoplasmic (Potential).				regulation of immune response|response to virus	integral to membrane|plasma membrane	protein phosphatase 1 binding|receptor activity			large_intestine(1)|ovary(1)|skin(1)	3				GBM - Glioblastoma multiforme(193;0.0188)		AGAGAAATGGCCTCTCCTCCT	0.582		NaN								HNSCC(37;0.09)			0	0	0	0.010818	0	28	31									
NLRP8	126205	broad.mit.edu	37	19	56482062	56482062	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr19:56482062C>T	uc002qmh.2	+	6	2605	c.2534C>T	c.(2533-2535)TCG>TTG	p.S845L	NLRP8_uc010etg.2_Missense_Mutation_p.S845L	NM_176811	NP_789781	Q86W28	NALP8_HUMAN	NLR family, pyrin domain containing 8	845	LRR 3.					cytoplasm	ATP binding			ovary(4)|breast(3)|central_nervous_system(2)|skin(2)|large_intestine(1)|kidney(1)	13		Colorectal(82;0.000147)|Ovarian(87;0.17)		GBM - Glioblastoma multiforme(193;0.0695)		GAGAGGCTGTCGTAAGTCTCC	0.473		NaN											0	0	0	0.01441	0	66	94									
ZNF324B	388569	broad.mit.edu	37	19	58965138	58965138	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr19:58965138G>A	uc002qsv.1	+	2	177	c.70G>A	c.(70-72)GCC>ACC	p.A24T	ZNF324B_uc002qsu.1_5'UTR|ZNF324B_uc010euq.1_Missense_Mutation_p.A24T	NM_207395	NP_997278	Q6AW86	Z324B_HUMAN	zinc finger protein 324B	24	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		all_cancers(17;1.81e-17)|all_epithelial(17;1.21e-12)|Lung NSC(17;2.8e-05)|all_lung(17;0.000139)|Colorectal(82;0.000147)|Renal(17;0.00528)|all_neural(62;0.0133)|Ovarian(87;0.156)|Medulloblastoma(540;0.232)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0164)|Lung(386;0.179)		AGCGCAGAGGGCCCTGTACCG	0.567		NaN											0	0	0	0.01441	0	39	58									
ZBTB45	84878	broad.mit.edu	37	19	59028486	59028486	+	Silent	SNP	T	T	C			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr19:59028486T>C	uc002qtd.2	-	2	847	c.555A>G	c.(553-555)CCA>CCG	p.P185P	ZBTB45_uc002qte.2_Silent_p.P185P|ZBTB45_uc002qtf.2_Silent_p.P185P	NM_032792	NP_116181	Q96K62	ZBT45_HUMAN	zinc finger and BTB domain containing 45	185	Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_cancers(17;1.81e-17)|all_epithelial(17;1.21e-12)|Lung NSC(17;2.8e-05)|all_lung(17;0.000139)|Colorectal(82;0.000147)|Renal(17;0.00528)|all_neural(62;0.0133)|Ovarian(87;0.156)|Medulloblastoma(540;0.232)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0165)|Lung(386;0.18)		TGGCAGGTGTTGGGGGCGCTG	0.692		NaN									OREG0025700	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.013726	0	31	36									
TPO	7173	broad.mit.edu	37	2	1488451	1488451	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr2:1488451C>A	uc002qww.2	+	9	1513	c.1422C>A	c.(1420-1422)GAC>GAA	p.D474E	TPO_uc010ewj.2_RNA|TPO_uc002qwu.2_Missense_Mutation_p.D474E|TPO_uc002qwr.2_Missense_Mutation_p.D474E|TPO_uc002qwx.2_Missense_Mutation_p.D474E|TPO_uc010yio.1_Missense_Mutation_p.D301E|TPO_uc010yip.1_Missense_Mutation_p.D474E|TPO_uc002qwy.1_5'UTR|TPO_uc002qwz.2_RNA	NM_000547	NP_000538	P07202	PERT_HUMAN	thyroid peroxidase isoform a	474	Extracellular (Potential).				cellular nitrogen compound metabolic process|hormone biosynthetic process|hydrogen peroxide catabolic process	cell surface|cytoplasm|integral to plasma membrane	calcium ion binding|heme binding|iodide peroxidase activity			ovary(7)|pancreas(6)|skin(5)|lung(1)|kidney(1)	20	all_hematologic(175;0.0487)|Acute lymphoblastic leukemia(172;0.0627)	all_cancers(51;0.0338)		all cancers(51;0.0356)|OV - Ovarian serous cystadenocarcinoma(76;0.0748)|Epithelial(75;0.12)	Carbimazole(DB00389)|Methimazole(DB00763)|Propylthiouracil(DB00550)	AAGGCTATGACTCCACCGCCA	0.602		NaN											1	0	7.26314e-15	0.007291	8.70836e-15	28	32									
MSGN1	343930	broad.mit.edu	37	2	17998252	17998252	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr2:17998252G>A	uc010yjt.1	+	1	467	c.467G>A	c.(466-468)AGC>AAC	p.S156N		NM_001105569	NP_001099039	A6NI15	MSGN1_HUMAN	mesogenin 1	156	Helix-loop-helix motif.				cell differentiation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.158)					CCTGTCTACAGCCAGAGAGGC	0.587		NaN											0	0	0	0.001855	0	12	27									
RHOB	388	broad.mit.edu	37	2	20647449	20647449	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq;WGS			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr2:20647449C>T	uc002rdv.2	+	1	615	c.223C>T	c.(223-225)CCG>TCG	p.P75S		NM_004040	NP_004031	P62745	RHOB_HUMAN	ras homolog gene family, member B precursor	75					angiogenesis|axon guidance|cell adhesion|endosome to lysosome transport|negative regulation of cell cycle|platelet activation|positive regulation of angiogenesis|protein transport|regulation of small GTPase mediated signal transduction|Rho protein signal transduction|transformed cell apoptosis	cytosol|late endosome membrane|nucleus|plasma membrane	GTP binding|GTPase activity|protein binding			ovary(1)|lung(1)	2	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)	all_epithelial(98;4.19e-09)|Lung NSC(108;0.00452)|Ovarian(717;0.0164)		OV - Ovarian serous cystadenocarcinoma(76;1.14e-22)|Epithelial(75;7.84e-19)		GCTCTCCTACCCGGACACCGA	0.647		NaN											0	0	0	0.01441	0	52	54									
C2orf44	80304	broad.mit.edu	37	2	24254029	24254029	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr2:24254029G>A	uc002rep.2	-	4	2071	c.1940C>T	c.(1939-1941)TCC>TTC	p.S647F	C2orf44_uc010eya.2_Missense_Mutation_p.P608S	NM_025203	NP_079479	Q9H6R7	CB044_HUMAN	hypothetical protein LOC80304 isoform 1	647							protein binding			ovary(1)|breast(1)	2	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					AATCCAGTGGGAATCTGCAAA	0.363		NaN											0	0	0	0.001984	0	7	15									
IFT172	26160	broad.mit.edu	37	2	27672643	27672643	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr2:27672643C>A	uc002rku.2	-	37	4126	c.4075G>T	c.(4075-4077)GAC>TAC	p.D1359Y	IFT172_uc010ezb.2_RNA	NM_015662	NP_056477	Q9UG01	IF172_HUMAN	selective LIM binding factor homolog	1359	TPR 11.				cilium assembly	cilium	binding			large_intestine(1)|ovary(1)	2	Acute lymphoblastic leukemia(172;0.155)					TTGACAAGGTCCAGATTCAGA	0.522		NaN											1	0	5.57489e-27	0.01441	7.31899e-27	47	44									
FSHR	2492	broad.mit.edu	37	2	49189908	49189908	+	Silent	SNP	G	G	A			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr2:49189908G>A	uc002rww.2	-	10	2126	c.2052C>T	c.(2050-2052)TAC>TAT	p.Y684Y	FSHR_uc002rwx.2_Silent_p.Y622Y|FSHR_uc010fbn.2_Silent_p.Y658Y	NM_000145	NP_000136	P23945	FSHR_HUMAN	follicle stimulating hormone receptor isoform 1	684	Cytoplasmic (Potential).				female gamete generation|male gonad development|spermatogenesis	integral to membrane|plasma membrane	follicle-stimulating hormone receptor activity|protein binding			ovary(4)|lung(2)|central_nervous_system(1)|skin(1)	8		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.181)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)		Choriogonadotropin alfa(DB00097)|Follitropin beta(DB00066)|Menotropins(DB00032)|Urofollitropin(DB00094)	GGACAAGTATGTAAGTGGAAC	0.358		NaN							Gonadal_Dysgenesis_46_XX				0	0	0	0.003954	0	20	54									
EHBP1	23301	broad.mit.edu	37	2	63176182	63176182	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr2:63176182G>A	uc002sby.2	+	14	2788	c.2306G>A	c.(2305-2307)AGT>AAT	p.S769N	EHBP1_uc010fcp.2_Missense_Mutation_p.S734N|EHBP1_uc002sbz.2_Missense_Mutation_p.S734N|EHBP1_uc002scb.2_Missense_Mutation_p.S734N	NM_015252	NP_056067	Q8NDI1	EHBP1_HUMAN	EH domain binding protein 1 isoform 1	769						cytoplasm|membrane				ovary(1)|breast(1)	2	Lung NSC(7;0.0951)|all_lung(7;0.169)		LUSC - Lung squamous cell carcinoma(7;7.74e-05)|Epithelial(17;0.189)			TACTCATATAGTAGAGATCTA	0.373		NaN							Hereditary_Prostate_Cancer				0	0	0	0.010504	0	20	13									
SFTPB	6439	broad.mit.edu	37	2	85894867	85894867	+	Nonsense_Mutation	SNP	C	C	A			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr2:85894867C>A	uc002sqh.2	-	2	136	c.130G>T	c.(130-132)GAG>TAG	p.E44*	SFTPB_uc002sqi.2_Nonsense_Mutation_p.E56*|SFTPB_uc002sqj.2_Nonsense_Mutation_p.E44*	NM_198843	NP_942140	P07988	PSPB_HUMAN	surfactant, pulmonary-associated protein B	44	Saposin A-type.				organ morphogenesis|respiratory gaseous exchange|sphingolipid metabolic process	extracellular space|lysosome				ovary(1)|central_nervous_system(1)	2						AATGCTTGCTCCAGGCTTTGG	0.592		NaN											1	0	4.88482e-21	0.01441	6.13868e-21	50	35									
TBC1D8	11138	broad.mit.edu	37	2	101624308	101624308	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr2:101624308G>A	uc010fiv.2	-	20	3529	c.3398C>T	c.(3397-3399)TCT>TTT	p.S1133F	RPL31_uc010yvu.1_Intron|RPL31_uc010yvv.1_Intron|RPL31_uc010fiu.1_Intron|TBC1D8_uc002tau.3_Missense_Mutation_p.S890F	NM_001102426	NP_001095896	O95759	TBCD8_HUMAN	TBC1 domain family, member 8	1133					blood circulation|positive regulation of cell proliferation	intracellular|membrane	calcium ion binding|Rab GTPase activator activity			ovary(3)	3						CTTAAGTTCAGATTGTGATTG	0.423		NaN											0	0	0	0.00874	0	33	142									
TBC1D8	11138	broad.mit.edu	37	2	101624437	101624437	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr2:101624437G>C	uc010fiv.2	-	20	3400	c.3269C>G	c.(3268-3270)GCT>GGT	p.A1090G	RPL31_uc010yvu.1_Intron|RPL31_uc010yvv.1_Intron|RPL31_uc010fiu.1_Intron|TBC1D8_uc002tau.3_Missense_Mutation_p.A847G	NM_001102426	NP_001095896	O95759	TBCD8_HUMAN	TBC1 domain family, member 8	1090					blood circulation|positive regulation of cell proliferation	intracellular|membrane	calcium ion binding|Rab GTPase activator activity			ovary(3)	3						CAGAAGTGAAGCTAAAATATG	0.448		NaN											0	0	0	0.009096	0	4	37									
TGFBRAP1	9392	broad.mit.edu	37	2	105890144	105890144	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr2:105890144C>T	uc002tcq.2	-	9	1753	c.1669G>A	c.(1669-1671)GGA>AGA	p.G557R	TGFBRAP1_uc010fjc.2_Intron|TGFBRAP1_uc002tcr.3_Missense_Mutation_p.G557R	NM_004257	NP_004248	Q8WUH2	TGFA1_HUMAN	transforming growth factor, beta receptor	557					regulation of transcription, DNA-dependent|transforming growth factor beta receptor signaling pathway	cytoplasm|membrane	SMAD binding|small GTPase regulator activity|transforming growth factor beta receptor binding			central_nervous_system(1)|skin(1)	2						ACCTGAACTCCGACCTGAAAG	0.403		NaN											0	0	0	0.00308	0	5	21									
ATF2	1386	broad.mit.edu	37	2	175979453	175979453	+	Silent	SNP	T	T	C			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr2:175979453T>C	uc002ujl.2	-	8	853	c.591A>G	c.(589-591)GTA>GTG	p.V197V	ATF2_uc010fqv.2_Silent_p.V148V|ATF2_uc002ujv.2_5'UTR|ATF2_uc002ujm.2_Silent_p.V139V|ATF2_uc002ujn.2_RNA|ATF2_uc002ujo.2_Intron|ATF2_uc002ujp.2_RNA|ATF2_uc002ujq.2_Silent_p.V197V|ATF2_uc002ujr.2_RNA|ATF2_uc010fqu.2_Silent_p.V179V|ATF2_uc002ujs.2_Silent_p.V139V|ATF2_uc002ujt.2_RNA|ATF2_uc002uju.2_RNA|ATF2_uc002ujw.1_Silent_p.V139V|ATF2_uc002ujx.1_RNA|ATF2_uc002ujy.1_Silent_p.V197V	NM_001880	NP_001871	P15336	ATF2_HUMAN	activating transcription factor 2	197					innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|regulation of sequence-specific DNA binding transcription factor activity|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	nucleoplasm	protein dimerization activity|sequence-specific DNA binding|transcription coactivator activity|zinc ion binding			lung(1)|breast(1)|pancreas(1)	3			OV - Ovarian serous cystadenocarcinoma(117;0.125)			CCTGGGTGATTACAGTACTTG	0.403		NaN											0	0	0	0.01441	0	118	93									
TTN	7273	broad.mit.edu	37	2	179613658	179613658	+	Missense_Mutation	SNP	A	A	G			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr2:179613658A>G	uc002unb.2	-	46	13693	c.13469T>C	c.(13468-13470)ATT>ACT	p.I4490T	TTN_uc010zfg.1_Intron|TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Intron	NM_133379	NP_596870	Q8WZ42	TITIN_HUMAN	titin isoform novex-3	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTTGTCATCAATCTTCTTTTG	0.313		NaN											0	0	0	0.003954	0	23	19									
TTN	7273	broad.mit.edu	37	2	179649056	179649056	+	Missense_Mutation	SNP	A	A	G			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr2:179649056A>G	uc010zfg.1	-	16	2740	c.2516T>C	c.(2515-2517)ATT>ACT	p.I839T	TTN_uc010zfh.1_Missense_Mutation_p.I793T|TTN_uc010zfi.1_Missense_Mutation_p.I793T|TTN_uc010zfj.1_Missense_Mutation_p.I793T|TTN_uc002unb.2_Missense_Mutation_p.I839T	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	839							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TAATGTGGCAATAGCACTACC	0.468		NaN											0	0	0	0.003271	0	27	30									
CCDC108	255101	broad.mit.edu	37	2	219900359	219900359	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr2:219900359G>A	uc002vjl.1	-	5	469	c.385C>T	c.(385-387)CAC>TAC	p.H129Y	CCDC108_uc010zkp.1_Missense_Mutation_p.H118Y|CCDC108_uc010zkq.1_Missense_Mutation_p.H64Y|CCDC108_uc002vjn.2_Missense_Mutation_p.H64Y	NM_194302	NP_919278	Q6ZU64	CC108_HUMAN	coiled-coil domain containing 108 isoform 1	129				H -> R (in Ref. 1; BAC86878).		integral to membrane	structural molecule activity			ovary(2)|upper_aerodigestive_tract(1)|pancreas(1)	4		Renal(207;0.0915)		Epithelial(149;1.12e-06)|all cancers(144;0.000196)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		TTTGGGGAGTGCATCTGAGTG	0.567		NaN											0	0	0	0.01441	0	63	16									
SCG2	7857	broad.mit.edu	37	2	224462395	224462395	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr2:224462395C>G	uc002vnm.2	-	2	1739	c.1606G>C	c.(1606-1608)GAC>CAC	p.D536H		NM_003469	NP_003460	P13521	SCG2_HUMAN	secretogranin II precursor	536					angiogenesis|endothelial cell migration|eosinophil chemotaxis|induction of positive chemotaxis|inflammatory response|MAPKKK cascade|negative regulation of apoptosis|negative regulation of endothelial cell proliferation|positive regulation of endothelial cell proliferation|protein secretion	extracellular space|stored secretory granule	chemoattractant activity|cytokine activity			ovary(1)	1		Renal(207;0.0112)|Lung NSC(271;0.0185)|all_lung(227;0.0271)		Epithelial(121;8.16e-11)|all cancers(144;4.66e-08)|Lung(261;0.00714)|LUSC - Lung squamous cell carcinoma(224;0.008)		TCCTGCAGGTCATCTTCAGAT	0.468		NaN											0	0	0	0.014323	0	19	10									
RALGAPA2	57186	broad.mit.edu	37	20	20610169	20610169	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr20:20610169C>A	uc002wrz.2	-	10	1214	c.1071G>T	c.(1069-1071)CAG>CAT	p.Q357H	RALGAPA2_uc010gcx.2_Missense_Mutation_p.Q61H|RALGAPA2_uc010zsg.1_Translation_Start_Site	NM_020343	NP_065076	Q2PPJ7	RGPA2_HUMAN	akt substrate AS250	357					activation of Ral GTPase activity	cytosol|nucleus	protein heterodimerization activity|Ral GTPase activator activity			ovary(1)	1						GGCTTTTGTCCTGCTCCGTGG	0.537		NaN											1	0	2.27795e-59	0.01441	3.11231e-59	104	111									
WFDC3	140686	broad.mit.edu	37	20	44418583	44418583	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr20:44418583G>T	uc002xpf.1	-	2	116	c.32C>A	c.(31-33)GCA>GAA	p.A11E	DNTTIP1_uc002xpk.2_5'Flank|WFDC3_uc002xpj.1_Intron|WFDC3_uc002xph.1_Intron|WFDC3_uc010ghh.1_Intron	NM_080614	NP_542181	Q8IUB2	WFDC3_HUMAN	WAP four-disulfide core domain 3 precursor	11						extracellular region	serine-type endopeptidase inhibitor activity				0		Myeloproliferative disorder(115;0.0122)				AGCAAGAAGTGCCTTCAGAAG	0.483		NaN											1	0	6.53348e-20	0.003755	8.08088e-20	28	63									
ZNF831	128611	broad.mit.edu	37	20	57768368	57768368	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr20:57768368C>T	uc002yan.2	+	1	2294	c.2294C>T	c.(2293-2295)CCT>CTT	p.P765L		NM_178457	NP_848552	Q5JPB2	ZN831_HUMAN	zinc finger protein 831	765						intracellular	nucleic acid binding|zinc ion binding			skin(13)|ovary(1)	14	all_lung(29;0.0085)					CCCCCAGCACCTGGCCCCCTC	0.647		NaN											0	0	0	0.001168	0	5	9									
DIDO1	11083	broad.mit.edu	37	20	61513072	61513072	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr20:61513072C>G	uc002ydr.1	-	16	4500	c.4236G>C	c.(4234-4236)AGG>AGC	p.R1412S	DIDO1_uc002yds.1_Missense_Mutation_p.R1412S	NM_033081	NP_149072	Q9BTC0	DIDO1_HUMAN	death inducer-obliterator 1 isoform c	1412					apoptosis|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			ovary(3)|skin(3)	6	Breast(26;5.68e-08)					CTTCAGGAGCCCTTTCCACCT	0.612		NaN											0	0	0	0.01441	0	69	70									
SAMD10	140700	broad.mit.edu	37	20	62608657	62608657	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr20:62608657C>G	uc002yhm.2	-	2	369	c.194G>C	c.(193-195)TGG>TCG	p.W65S	SAMD10_uc002yhn.2_RNA	NM_080621	NP_542188	Q9BYL1	SAM10_HUMAN	sterile alpha motif domain containing 10	65											0	all_cancers(38;2.14e-11)|all_epithelial(29;3.41e-13)|Lung NSC(23;3.41e-09)|all_lung(23;1.06e-08)					GGAGTCATGCCACGTGAGGCT	0.667		NaN											0	0	0	0.01441	0	98	80									
PRPF6	24148	broad.mit.edu	37	20	62664245	62664245	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr20:62664245G>T	uc002yho.2	+	21	2893	c.2725G>T	c.(2725-2727)GGG>TGG	p.G909W	PRPF6_uc002yhp.2_Missense_Mutation_p.G869W|NCRNA00176_uc002yhq.2_5'Flank|NCRNA00176_uc011abq.1_5'Flank	NM_012469	NP_036601	O94906	PRP6_HUMAN	PRP6 pre-mRNA processing factor 6 homolog	909					assembly of spliceosomal tri-snRNP|positive regulation of transcription from RNA polymerase II promoter|spliceosome assembly	catalytic step 2 spliceosome|nucleoplasm|U4/U6 snRNP|U4/U6 x U5 tri-snRNP complex|U5 snRNP	androgen receptor binding|ribonucleoprotein binding|transcription coactivator activity			ovary(2)	2	all_cancers(38;6.47e-12)|all_epithelial(29;1.26e-13)|Lung NSC(23;9.37e-10)|all_lung(23;3.23e-09)					GCCTCGGCATGGGGAGCTGTG	0.642		NaN											1	0	7.92952e-12	0.003954	9.1795e-12	25	23									
MYT1	4661	broad.mit.edu	37	20	62871155	62871155	+	Missense_Mutation	SNP	A	A	G			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr20:62871155A>G	uc002yii.2	+	22	3500	c.3136A>G	c.(3136-3138)AAC>GAC	p.N1046D	MYT1_uc002yij.2_Missense_Mutation_p.N705D|MYT1_uc002yik.2_Missense_Mutation_p.N12D	NM_004535	NP_004526	Q01538	MYT1_HUMAN	myelin transcription factor 1	1046					cell differentiation|nervous system development	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2	all_cancers(38;1.82e-11)|all_epithelial(29;3.3e-13)|Lung NSC(23;5.21e-10)|all_lung(23;1.92e-09)					CGAGGAGGAGAACAAGCTCAT	0.572		NaN											0	0	0	0.01441	0	88	73									
BAGE2	85319	broad.mit.edu	37	21	11097575	11097575	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr21:11097575C>A	uc002yit.1	-	2	295	c.87G>T	c.(85-87)TGG>TGT	p.W29C	BAGE_uc002yix.2_RNA	NM_182482	NP_872288			B melanoma antigen family, member 2 precursor												0			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		gctccaacctccagctcacca	0.095		NaN											1	0	9.31168e-06	0.001855	9.90156e-06	11	79									
PDE9A	5152	broad.mit.edu	37	21	44192566	44192566	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr21:44192566C>A	uc002zbm.2	+	19	1767	c.1704C>A	c.(1702-1704)GAC>GAA	p.D568E	PDE9A_uc002zbn.2_Missense_Mutation_p.D441E|PDE9A_uc002zbo.2_Missense_Mutation_p.D515E|PDE9A_uc002zbp.2_Missense_Mutation_p.D361E|PDE9A_uc002zbq.2_Missense_Mutation_p.D466E|PDE9A_uc002zbs.2_Missense_Mutation_p.D361E|PDE9A_uc002zbr.2_Missense_Mutation_p.D361E|PDE9A_uc002zbt.2_Missense_Mutation_p.D440E|PDE9A_uc002zbu.2_Missense_Mutation_p.D434E|PDE9A_uc002zbv.2_Missense_Mutation_p.D408E|PDE9A_uc002zbw.2_Missense_Mutation_p.D351E|PDE9A_uc002zbx.2_Missense_Mutation_p.D508E|PDE9A_uc002zby.2_Missense_Mutation_p.D351E|PDE9A_uc002zbz.2_Missense_Mutation_p.D460E|PDE9A_uc002zca.2_Missense_Mutation_p.D527E|PDE9A_uc002zcb.2_Missense_Mutation_p.D542E|PDE9A_uc002zcc.2_Missense_Mutation_p.D467E|PDE9A_uc002zcd.2_Missense_Mutation_p.D482E|PDE9A_uc002zce.2_Missense_Mutation_p.D501E|PDE9A_uc002zcf.2_Missense_Mutation_p.D361E|PDE9A_uc002zcg.2_Missense_Mutation_p.D361E|PDE9A_uc002zch.2_Missense_Mutation_p.D351E	NM_002606	NP_002597	O76083	PDE9A_HUMAN	phosphodiesterase 9A isoform a	568					platelet activation|signal transduction	cytosol|endoplasmic reticulum|Golgi apparatus|perinuclear region of cytoplasm|ruffle membrane	3',5'-cyclic-GMP phosphodiesterase activity|metal ion binding|protein binding			ovary(1)|skin(1)	2						AGAAGACTGACAGCTTGACGT	0.532		NaN											1	0	2.0095e-06	0.001984	2.18626e-06	5	18									
OR11H1	81061	broad.mit.edu	37	22	16449133	16449133	+	Silent	SNP	A	A	C			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr22:16449133A>C	uc011agd.1	-	1	672	c.672T>G	c.(670-672)GGT>GGG	p.G224G		NM_001005239	NP_001005239	Q8NG94	O11H1_HUMAN	olfactory receptor, family 11, subfamily H,	224	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_hematologic(4;0.00567)|Acute lymphoblastic leukemia(84;0.0977)	all_epithelial(15;0.208)		Kidney(3;0.00216)|KIRC - Kidney renal clear cell carcinoma(3;0.00244)|Lung(27;0.0724)|COAD - Colon adenocarcinoma(3;0.211)		AGAGGAAGTTACCAAAAATAA	0.433		NaN											0	0	0	0.01441	0	25	31									
MYO18B	84700	broad.mit.edu	37	22	26173598	26173598	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr22:26173598G>T	uc003abz.1	+	8	2168	c.1918G>T	c.(1918-1920)GCA>TCA	p.A640S	MYO18B_uc003aca.1_Missense_Mutation_p.A521S|MYO18B_uc010guy.1_Missense_Mutation_p.A521S|MYO18B_uc010guz.1_Missense_Mutation_p.A521S|MYO18B_uc011aka.1_5'UTR|MYO18B_uc011akb.1_Missense_Mutation_p.A153S	NM_032608	NP_115997	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	640	Myosin head-like.					nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			ovary(5)|central_nervous_system(3)|large_intestine(2)|breast(2)	12						TGGCTCCATGGCACAGCGGGC	0.647		NaN											1	0	1.12685e-05	0.004482	1.19284e-05	6	30									
MYO18B	84700	broad.mit.edu	37	22	26219621	26219621	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr22:26219621C>A	uc003abz.1	+	13	2921	c.2671C>A	c.(2671-2673)CTC>ATC	p.L891I	MYO18B_uc003aca.1_Missense_Mutation_p.L772I|MYO18B_uc010guy.1_Missense_Mutation_p.L772I|MYO18B_uc010guz.1_Missense_Mutation_p.L772I|MYO18B_uc011aka.1_Missense_Mutation_p.L45I|MYO18B_uc011akb.1_Missense_Mutation_p.L404I	NM_032608	NP_115997	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	891	Myosin head-like.					nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			ovary(5)|central_nervous_system(3)|large_intestine(2)|breast(2)	12						CCGATGGGGCCTCGAGGATGA	0.597		NaN											1	0	3.45943e-77	0.01441	4.78215e-77	103	112									
IL2RB	3560	broad.mit.edu	37	22	37524836	37524836	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr22:37524836G>T	uc003aqv.1	-	10	1087	c.956C>A	c.(955-957)GCA>GAA	p.A319E		NM_000878	NP_000869	P14784	IL2RB_HUMAN	interleukin 2 receptor beta precursor	319	Cytoplasmic (Potential).				interspecies interaction between organisms|positive regulation of survival gene product expression|protein complex assembly	external side of plasma membrane|integral to plasma membrane	interleukin-2 receptor activity				0					Aldesleukin(DB00041)|Basiliximab(DB00074)|Daclizumab(DB00111)|Denileukin diftitox(DB00004)	GATCTCAGGTGCCAGGCCGCC	0.627		NaN											1	0	3.99206e-14	0.007413	4.7621e-14	14	37									
SGSM3	27352	broad.mit.edu	37	22	40804819	40804819	+	Silent	SNP	C	C	T	rs140197200		TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr22:40804819C>T	uc003ayu.1	+	18	2084	c.1875C>T	c.(1873-1875)GTC>GTT	p.V625V	SGSM3_uc011aos.1_Silent_p.V558V|SGSM3_uc011aot.1_Silent_p.V536V|SGSM3_uc010gyd.1_Silent_p.V696V	NM_015705	NP_056520	Q96HU1	SGSM3_HUMAN	small G protein signaling modulator 3	625	RUN.				cell cycle arrest|Rap protein signal transduction	cytoplasm	Rab GTPase activator activity|Rab GTPase binding			ovary(2)	2						ATGGCAAAGTCCTGACCCCGG	0.652		NaN											0	0	0	0.012319	0	15	49									
TEF	7008	broad.mit.edu	37	22	41783535	41783535	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr22:41783535G>A	uc003azy.2	+	2	424	c.338G>A	c.(337-339)AGC>AAC	p.S113N	TEF_uc003azx.2_Missense_Mutation_p.S83N|TEF_uc011apa.1_Missense_Mutation_p.S118N	NM_003216	NP_003207	Q10587	TEF_HUMAN	thyrotrophic embryonic factor isoform 1	113					rhythmic process	nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1						ATCCCCGCCAGCCCCACCCAC	0.587		NaN											0	0	0	0.01441	0	100	81									
MAPK11	5600	broad.mit.edu	37	22	50705436	50705436	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr22:50705436C>T	uc003bkr.2	-	7	595	c.537G>A	c.(535-537)ATG>ATA	p.M179I	MAPK11_uc010hax.2_Missense_Mutation_p.M1I|MAPK11_uc011ars.1_RNA|MAPK11_uc010hay.1_RNA|MAPK11_uc011art.1_3'UTR|MAPK11_uc010haz.2_Missense_Mutation_p.M71I	NM_002751	NP_002742	Q15759	MK11_HUMAN	mitogen-activated protein kinase 11	179	Protein kinase.				activation of MAPK activity|innate immune response|mRNA metabolic process|muscle cell differentiation|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|positive regulation of muscle cell differentiation|Ras protein signal transduction|regulation of sequence-specific DNA binding transcription factor activity|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|MAP kinase activity|protein binding			lung(1)|breast(1)	2		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		CATAGCCGGTCATCTCCTCGT	0.657		NaN											0	0	0	0.010729	0	12	44									
ZNF197	10168	broad.mit.edu	37	3	44685245	44685245	+	Nonsense_Mutation	SNP	G	G	T	rs61751651		TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr3:44685245G>T	uc003cnm.2	+	6	2829	c.2623G>T	c.(2623-2625)GAA>TAA	p.E875*	ZNF197_uc003cnn.2_Intron|ZNF197_uc003cno.2_Intron|ZNF197_uc003cnp.2_Intron	NM_006991	NP_008922	O14709	ZN197_HUMAN	zinc finger protein 197 isoform 1	875	C2H2-type 19.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(3)|skin(1)	4				KIRC - Kidney renal clear cell carcinoma(197;0.0478)|Kidney(197;0.0598)		AAAAACCTACGAATGTCATGT	0.383		NaN											1	0	7.33532e-06	0.003954	7.87123e-06	22	44									
CCR1	1230	broad.mit.edu	37	3	46245233	46245233	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr3:46245233C>T	uc003cph.1	-	2	643	c.572G>A	c.(571-573)AGC>AAC	p.S191N	CCR3_uc003cpg.1_Intron	NM_001295	NP_001286	P32246	CCR1_HUMAN	chemokine (C-C motif) receptor 1	191	Extracellular (Potential).				cell adhesion|cell-cell signaling|cytokine-mediated signaling pathway|dendritic cell chemotaxis|elevation of cytosolic calcium ion concentration|G-protein signaling, coupled to cyclic nucleotide second messenger|immune response|inflammatory response	integral to plasma membrane	C-C chemokine receptor activity			skin(2)|pancreas(1)	3				BRCA - Breast invasive adenocarcinoma(193;0.00113)|KIRC - Kidney renal clear cell carcinoma(197;0.0172)|Kidney(197;0.0203)		CTCTCGTAGGCTTTCGTGAGG	0.493		NaN											0	0	0	0.014323	0	21	37									
LTF	4057	broad.mit.edu	37	3	46484956	46484956	+	Missense_Mutation	SNP	T	T	C			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr3:46484956T>C	uc003cpq.2	-	13	1669	c.1631A>G	c.(1630-1632)TAC>TGC	p.Y544C	LTF_uc003fzr.2_Missense_Mutation_p.Y500C|LTF_uc010hjh.2_Missense_Mutation_p.Y542C|LTF_uc003cpr.2_Missense_Mutation_p.Y531C	NM_002343	NP_002334	P02788	TRFL_HUMAN	lactotransferrin precursor	544	Transferrin-like 2.				cellular iron ion homeostasis|defense response to bacterium|humoral immune response|iron ion transport	extracellular region|stored secretory granule	ferric iron binding|heparin binding|protein binding|serine-type endopeptidase activity			central_nervous_system(2)|ovary(1)|lung(1)	4				all cancers(1;7.55e-14)|GBM - Glioblastoma multiforme(1;2.1e-09)|Epithelial(1;9.25e-07)|Colorectal(1;3.81e-05)|BRCA - Breast invasive adenocarcinoma(193;0.00129)|COAD - Colon adenocarcinoma(1;0.00308)|KIRC - Kidney renal clear cell carcinoma(197;0.0205)|Kidney(197;0.0242)|OV - Ovarian serous cystadenocarcinoma(275;0.089)	Pefloxacin(DB00487)	GTAGCCGTAGTATCTCTCGTT	0.542		NaN											0	0	0	0.01441	0	45	150									
WDR6	11180	broad.mit.edu	37	3	49051677	49051677	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr3:49051677C>T	uc003cvj.2	+	3	2845	c.2707C>T	c.(2707-2709)CCC>TCC	p.P903S	WDR6_uc011bby.1_Missense_Mutation_p.P351S|WDR6_uc010hkn.2_Missense_Mutation_p.P847S|WDR6_uc011bbz.1_Missense_Mutation_p.P822S	NM_018031	NP_060501	Q9NNW5	WDR6_HUMAN	WD repeat domain 6 protein	873	WD 13.				cell cycle arrest|negative regulation of cell proliferation	cytoplasm				central_nervous_system(1)	1				Kidney(197;9.12e-07)|KIRC - Kidney renal clear cell carcinoma(197;1.32e-05)|BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|OV - Ovarian serous cystadenocarcinoma(275;0.000155)		ACTTGACCAGCCCGGCCTTGG	0.577		NaN									OREG0015565	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.009535	0	24	29									
DNAH1	25981	broad.mit.edu	37	3	52412779	52412779	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr3:52412779G>T	uc011bef.1	+	47	7621	c.7360G>T	c.(7360-7362)GAC>TAC	p.D2454Y		NM_015512	NP_056327	Q9P2D7	DYH1_HUMAN	dynein, axonemal, heavy chain 1	2454					ciliary or flagellar motility|microtubule-based movement|response to mechanical stimulus	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			large_intestine(3)	3				BRCA - Breast invasive adenocarcinoma(193;2.02e-05)|OV - Ovarian serous cystadenocarcinoma(275;0.000207)|Kidney(197;0.0022)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		GCTCATGGCTGACCCGGCCAA	0.627		NaN											1	0	6.15735e-50	0.01441	8.31596e-50	68	62									
STAB1	23166	broad.mit.edu	37	3	52538860	52538860	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr3:52538860C>A	uc003dej.2	+	12	1419	c.1345C>A	c.(1345-1347)CAG>AAG	p.Q449K	STAB1_uc003dei.1_Missense_Mutation_p.Q449K	NM_015136	NP_055951	Q9NY15	STAB1_HUMAN	stabilin 1 precursor	449	Extracellular (Potential).|FAS1 1.				cell adhesion|cell-cell signaling|defense response to bacterium|inflammatory response|negative regulation of angiogenesis|receptor-mediated endocytosis	integral to plasma membrane	bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			large_intestine(3)|upper_aerodigestive_tract(2)|central_nervous_system(1)|breast(1)|skin(1)|pancreas(1)	9				BRCA - Breast invasive adenocarcinoma(193;1.73e-05)|Kidney(197;0.00182)|KIRC - Kidney renal clear cell carcinoma(197;0.00205)|OV - Ovarian serous cystadenocarcinoma(275;0.0482)		GCTGGCCGGGCAGGAGATCAC	0.607		NaN											1	0	0.000673444	0.008291	0.00069412	11	32									
ARHGAP31	57514	broad.mit.edu	37	3	119120886	119120886	+	Silent	SNP	G	G	A			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr3:119120886G>A	uc003ecj.3	+	10	1819	c.1287G>A	c.(1285-1287)CCG>CCA	p.P429P		NM_020754	NP_065805	Q2M1Z3	RHG31_HUMAN	Cdc42 GTPase-activating protein	429					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|focal adhesion|lamellipodium	GTPase activator activity			ovary(2)	2						GGCCCCCACCGGAACAGCTGA	0.617		NaN											0	0	0	0.003163	0	15	46									
EPHB1	2047	broad.mit.edu	37	3	134968233	134968233	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr3:134968233G>A	uc003eqt.2	+	15	2966	c.2746G>A	c.(2746-2748)GTG>ATG	p.V916M	EPHB1_uc003equ.2_Missense_Mutation_p.V477M	NM_004441	NP_004432	P54762	EPHB1_HUMAN	ephrin receptor EphB1 precursor	916	Cytoplasmic (Potential).|SAM.					integral to plasma membrane	ATP binding|ephrin receptor activity|protein binding			lung(11)|ovary(6)|stomach(4)|breast(3)|central_nervous_system(2)|skin(2)|large_intestine(1)|pancreas(1)	30						CTTTACCACCGTGGATGACTG	0.587		NaN											0	0	0	0.009718	0	41	33									
TBCCD1	55171	broad.mit.edu	37	3	186276258	186276258	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr3:186276258C>T	uc003fqg.2	-	3	569	c.440G>A	c.(439-441)AGA>AAA	p.R147K	TBCCD1_uc011bry.1_Missense_Mutation_p.R147K|TBCCD1_uc003fqh.2_Missense_Mutation_p.R51K	NM_018138	NP_060608	Q9NVR7	TBCC1_HUMAN	TBCC domain containing 1	147					cell morphogenesis|maintenance of centrosome location|maintenance of Golgi location|regulation of cell migration|regulation of cell shape	spindle pole centrosome	binding			large_intestine(1)|ovary(1)	2	all_cancers(143;3.75e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;4.3e-21)	GBM - Glioblastoma multiforme(93;0.0474)		AGATTTGTTTCTGGGACTGGG	0.408		NaN											0	0	0	0.014323	0	19	81									
TP63	8626	broad.mit.edu	37	3	189586386	189586386	+	Missense_Mutation	SNP	G	G	A	rs113993967		TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr3:189586386G>A	uc003fry.2	+	8	1099	c.1010G>A	c.(1009-1011)CGA>CAA	p.R337Q	TP63_uc003frx.2_Missense_Mutation_p.R337Q|TP63_uc003frz.2_Missense_Mutation_p.R337Q|TP63_uc010hzc.1_Missense_Mutation_p.R337Q|TP63_uc003fsa.2_Missense_Mutation_p.R243Q|TP63_uc003fsb.2_Missense_Mutation_p.R243Q|TP63_uc003fsc.2_Missense_Mutation_p.R243Q|TP63_uc003fsd.2_Missense_Mutation_p.R243Q|TP63_uc010hzd.1_Missense_Mutation_p.R158Q|TP63_uc003fse.1_Missense_Mutation_p.R218Q	NM_003722	NP_003713	Q9H3D4	P63_HUMAN	tumor protein p63 isoform 1	337					anti-apoptosis|cellular response to UV|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|mitotic cell cycle G1/S transition DNA damage checkpoint|negative regulation of transcription from RNA polymerase II promoter|Notch signaling pathway|positive regulation of Notch signaling pathway|protein homotetramerization|regulation of neuron apoptosis|response to gamma radiation|response to X-ray	chromatin|cytosol|dendrite|Golgi apparatus|transcription factor complex	chromatin binding|damaged DNA binding|double-stranded DNA binding|identical protein binding|metal ion binding|p53 binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			skin(5)|lung(4)|ovary(2)|upper_aerodigestive_tract(1)	12	all_cancers(143;3.35e-10)|Ovarian(172;0.0925)		Lung(62;3.33e-05)	GBM - Glioblastoma multiforme(93;0.0227)		GTCCTGGGCCGACGCTGCTTT	0.483		NaN							Hay-Wells_syndrome	HNSCC(45;0.13)			0	0	0	0.001984	0	6	17									
IL1RAP	3556	broad.mit.edu	37	3	190366314	190366314	+	Silent	SNP	G	G	A			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr3:190366314G>A	uc003fsm.1	+	12	1739	c.1533G>A	c.(1531-1533)GTG>GTA	p.V511V	IL1RAP_uc010hzg.1_Silent_p.V511V|IL1RAP_uc003fsn.1_RNA|IL1RAP_uc003fso.1_Silent_p.V511V|IL1RAP_uc003fsp.1_RNA|IL1RAP_uc003fsq.2_Intron	NM_002182	NP_002173	Q9NPH3	IL1AP_HUMAN	interleukin 1 receptor accessory protein isoform	511	Cytoplasmic (Potential).|TIR.				inflammatory response|innate immune response|protein complex assembly	extracellular region|integral to plasma membrane				ovary(1)	1	all_cancers(143;3.61e-10)|Ovarian(172;0.0733)|Breast(254;0.21)		Lung(62;1.95e-06)|LUSC - Lung squamous cell carcinoma(58;2.05e-06)	GBM - Glioblastoma multiforme(93;0.00851)		AAACGAAGGTGAAAGAGCTGA	0.502		NaN											0	0	0	0.006122	0	15	68									
TMEM175	84286	broad.mit.edu	37	4	951684	951684	+	Silent	SNP	G	G	T	rs141810982	byFrequency	TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr4:951684G>T	uc003gbq.2	+	11	1013	c.915G>T	c.(913-915)GCG>GCT	p.A305A	TMEM175_uc003gbr.2_Silent_p.A223A|TMEM175_uc003gbu.2_Silent_p.A223A|TMEM175_uc003gbs.2_Silent_p.A188A|TMEM175_uc003gbt.2_Silent_p.A188A|TMEM175_uc003gbv.2_Silent_p.A188A|TMEM175_uc010ibm.2_Silent_p.A121A	NM_032326	NP_115702	Q9BSA9	TM175_HUMAN	transmembrane protein 175	305						integral to membrane					0			OV - Ovarian serous cystadenocarcinoma(23;0.0158)			CCCTGAGTGCGACCGGGCCGC	0.622		NaN											1	0	2.43468e-25	0.01441	3.16105e-25	46	47									
WHSC1	7468	broad.mit.edu	37	4	1936889	1936889	+	Missense_Mutation	SNP	A	A	G			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr4:1936889A>G	uc003gdz.3	+	7	1750	c.1574A>G	c.(1573-1575)AAA>AGA	p.K525R	WHSC1_uc003geb.3_Missense_Mutation_p.K525R|WHSC1_uc003gec.3_Missense_Mutation_p.K525R|WHSC1_uc003ged.3_Missense_Mutation_p.K525R|WHSC1_uc003gee.3_RNA|WHSC1_uc003gef.3_RNA|WHSC1_uc003gdy.1_Missense_Mutation_p.K525R|WHSC1_uc010icd.1_Missense_Mutation_p.K525R|WHSC1_uc003gea.1_Missense_Mutation_p.K525R|WHSC1_uc010ice.1_Missense_Mutation_p.K525R|WHSC1_uc003geh.1_Missense_Mutation_p.K525R	NM_001042424	NP_001035889	O96028	NSD2_HUMAN	Wolf-Hirschhorn syndrome candidate 1 protein	525					anatomical structure morphogenesis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|cytoplasm|nuclear membrane|nucleolus	DNA binding|histone-lysine N-methyltransferase activity|zinc ion binding			ovary(3)|lung(3)|skin(2)|pancreas(1)	9		all_epithelial(65;1.34e-05)	OV - Ovarian serous cystadenocarcinoma(23;0.00606)	STAD - Stomach adenocarcinoma(129;0.232)		AATGGGAAAAAAAGAAACCAC	0.468		NaN	T	IGH@	MM								0	0	0	0.001168	0	6	19									
C4orf14	84273	broad.mit.edu	37	4	57842717	57842717	+	Silent	SNP	G	G	T			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr4:57842717G>T	uc003hck.2	-	1	1110	c.1035C>A	c.(1033-1035)GGC>GGA	p.G345G	POLR2B_uc003hcl.1_5'Flank|POLR2B_uc011cae.1_5'Flank|POLR2B_uc011caf.1_5'Flank	NM_032313	NP_115689	Q8NC60	CD014_HUMAN	hypothetical protein LOC84273	345							GTP binding			ovary(1)|breast(1)	2	Glioma(25;0.08)|all_neural(26;0.181)					CGTTGGTGGCGCCCACTAAGT	0.607		NaN											1	0	1.52009e-12	0.003163	1.77722e-12	14	40									
BANK1	55024	broad.mit.edu	37	4	102946511	102946511	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr4:102946511C>G	uc003hvy.3	+	9	1713	c.1439C>G	c.(1438-1440)TCT>TGT	p.S480C	BANK1_uc003hvx.3_Missense_Mutation_p.S465C|BANK1_uc010ill.2_Missense_Mutation_p.S347C|BANK1_uc003hvz.3_Missense_Mutation_p.S450C	NM_017935	NP_060405	Q8NDB2	BANK1_HUMAN	B-cell scaffold protein with ankyrin repeats 1	480					B cell activation					ovary(2)|skin(1)	3		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;2.7e-07)		AGTGAGAGTTCTGAAGACCAG	0.493		NaN											0	0	0	0.00499	0	14	56									
ANK2	287	broad.mit.edu	37	4	114278218	114278218	+	Missense_Mutation	SNP	A	A	G			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr4:114278218A>G	uc003ibe.3	+	38	8544	c.8444A>G	c.(8443-8445)CAA>CGA	p.Q2815R	ANK2_uc003ibd.3_Intron|ANK2_uc003ibf.3_Intron|ANK2_uc011cgc.1_Intron|ANK2_uc003ibg.3_Intron|ANK2_uc003ibh.3_Intron|ANK2_uc011cgd.1_Missense_Mutation_p.Q117R|ANK2_uc011cgb.1_Missense_Mutation_p.Q2830R	NM_001148	NP_001139	Q01484	ANK2_HUMAN	ankyrin 2 isoform 1	2782					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding|protein binding			central_nervous_system(7)|ovary(3)|large_intestine(2)|breast(1)|skin(1)	14		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		TTAGCTCTCCAAGGCACTCAT	0.463		NaN											0	0	0	0.010818	0	30	36									
GUCY1A3	2982	broad.mit.edu	37	4	156631721	156631721	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr4:156631721C>T	uc003iov.2	+	7	940	c.404C>T	c.(403-405)TCT>TTT	p.S135F	GUCY1A3_uc003iou.2_Missense_Mutation_p.S135F|GUCY1A3_uc010iqc.2_Missense_Mutation_p.S135F|GUCY1A3_uc003iow.2_Missense_Mutation_p.S135F|GUCY1A3_uc010iqd.2_Missense_Mutation_p.S134F|GUCY1A3_uc003iox.2_Missense_Mutation_p.S135F|GUCY1A3_uc003ioz.2_5'UTR|GUCY1A3_uc003ioy.2_Missense_Mutation_p.S135F|GUCY1A3_uc010iqe.2_Intron|GUCY1A3_uc003ipa.2_Intron|GUCY1A3_uc003ipb.2_Missense_Mutation_p.S135F	NM_000856	NP_000847	Q02108	GCYA3_HUMAN	guanylate cyclase 1, soluble, alpha 3 isoform A	135				VIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLK QSSHCQEAGKRGR -> LSKNLLVKRFLKYVTRKMKTSLGW LEAPLKIFKQLQYPSETEQPLPRSRKKGQ (in Ref. 1).	blood circulation|intracellular signal transduction|nitric oxide mediated signal transduction|platelet activation	guanylate cyclase complex, soluble	GTP binding|guanylate cyclase activity|heme binding|receptor activity			central_nervous_system(2)|ovary(1)|skin(1)	4	all_hematologic(180;0.24)	Renal(120;0.0854)		COAD - Colon adenocarcinoma(41;0.17)		ATCAAAGAATCTCTTGGTGAA	0.383		NaN											0	0	0	0.005524	0	30	25									
AADAT	51166	broad.mit.edu	37	4	170988519	170988519	+	Silent	SNP	T	T	C			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr4:170988519T>C	uc003isr.2	-	9	1263	c.921A>G	c.(919-921)CTA>CTG	p.L307L	AADAT_uc003iss.2_Silent_p.L307L|AADAT_uc003ist.2_Silent_p.L311L	NM_016228	NP_057312	Q8N5Z0	AADAT_HUMAN	kynurenine aminotransferase II	307					2-oxoglutarate metabolic process|biosynthetic process|glutamate metabolic process|lysine catabolic process	mitochondrial matrix	2-aminoadipate transaminase activity|kynurenine-oxoglutarate transaminase activity|protein homodimerization activity				0		Prostate(90;0.00601)|Renal(120;0.0183)|all_neural(102;0.122)|Melanoma(52;0.17)		GBM - Glioblastoma multiforme(119;0.0355)|LUSC - Lung squamous cell carcinoma(193;0.118)	L-Glutamic Acid(DB00142)|Pyridoxal Phosphate(DB00114)	CCCATTCGTGTAGAAGCTGTG	0.343		NaN											0	0	0	0.012213	0	25	31									
FAT1	2195	broad.mit.edu	37	4	187525600	187525600	+	Silent	SNP	C	C	A			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr4:187525600C>A	uc003izf.2	-	18	10667	c.10479G>T	c.(10477-10479)CCG>CCT	p.P3493P		NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor	3493	Extracellular (Potential).|Cadherin 32.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12						GGACTCCTTGCGGGTTAACTT	0.433		NaN								HNSCC(5;0.00058)			1	0	1.3612e-06	0.003163	1.49478e-06	12	31									
LRRC14B	389257	broad.mit.edu	37	5	192543	192543	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr5:192543C>A	uc003jal.1	+	1	918	c.890C>A	c.(889-891)ACG>AAG	p.T297K		NM_001080478	NP_001073947	A6NHZ5	LR14B_HUMAN	leucine rich repeat containing 14B	297	LRR 1.									skin(1)	1						AAGATCCCGACGCTGCTTGGG	0.657		NaN											1	0	0.000602214	0.000602	0.000623438	3	4									
TERT	7015	broad.mit.edu	37	5	1294371	1294371	+	Silent	SNP	G	G	A			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr5:1294371G>A	uc003jcb.1	-	2	688	c.630C>T	c.(628-630)GCC>GCT	p.A210A	TERT_uc003jca.1_Silent_p.A210A|TERT_uc003jcc.1_Silent_p.A210A|TERT_uc003jcd.1_RNA|TERT_uc003jce.1_RNA	NM_198253	NP_937983	O14746	TERT_HUMAN	telomerase reverse transcriptase isoform 1	210	RNA-interacting domain 1.				anti-apoptosis|DNA strand elongation|replicative senescence|telomere formation via telomerase|telomere maintenance via telomerase	cytoplasm|nucleolus|PML body|telomerase holoenzyme complex	protein homodimerization activity|telomeric DNA binding|telomeric RNA binding|telomeric template RNA reverse transcriptase activity			lung(7)|ovary(2)|central_nervous_system(2)|skin(1)	12	all_cancers(3;3.17e-16)|Lung NSC(6;8.55e-15)|all_lung(6;7.2e-14)|all_epithelial(6;1.87e-10)		Epithelial(17;0.00105)|all cancers(22;0.00178)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|Lung(60;0.185)			GGGGGACCCCGGCCTCCCTGA	0.746		NaN							TERT_Mutation-Associated_Haematological_Disorders|Congenital_Dyskeratosis|Pulmonary_Fibrosis_Idiopathic				0	0	0	0.009096	0	4	1									
PDZD2	23037	broad.mit.edu	37	5	32059421	32059421	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr5:32059421C>G	uc003jhl.2	+	13	2665	c.2277C>G	c.(2275-2277)AGC>AGG	p.S759R	PDZD2_uc003jhm.2_Missense_Mutation_p.S759R|PDZD2_uc011cnx.1_Missense_Mutation_p.S585R	NM_178140	NP_835260	O15018	PDZD2_HUMAN	PDZ domain containing 2	759	PDZ 4.				cell adhesion	cell-cell junction|endoplasmic reticulum|extracellular region|nucleus				central_nervous_system(4)|ovary(2)|skin(2)|large_intestine(1)	9						ACATTCACAGCCTTGCTCCAG	0.468		NaN											0	0	0	0.007413	0	16	15									
MGC42105	167359	broad.mit.edu	37	5	43245942	43245942	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr5:43245942G>A	uc003jno.2	+	2	946	c.65G>A	c.(64-66)CGC>CAC	p.R22H		NM_153361	NP_699192	Q8IY84	NIM1_HUMAN	serine/threonine-protein kinase NIM1	22							ATP binding|magnesium ion binding|protein serine/threonine kinase activity			lung(4)|ovary(2)|stomach(1)|large_intestine(1)|breast(1)	9						TGGGATCGGCGCGACAGTGTA	0.597		NaN											0	0	0	0.01441	0	75	57									
RGS7BP	401190	broad.mit.edu	37	5	63871635	63871635	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr5:63871635C>T	uc003jtj.2	+	3	367	c.367C>T	c.(367-369)CGG>TGG	p.R123W	RGS7BP_uc011cqu.1_5'UTR	NM_001029875	NP_001025046	Q6MZT1	R7BP_HUMAN	regulator of G-protein signaling 7 binding	123					negative regulation of signal transduction	cytoplasm|nucleus|plasma membrane					0		Lung NSC(810;0.000518)|Prostate(74;0.0435)|Ovarian(174;0.186)		Lung(70;0.147)		AGAAATCTGTCGGCTTTACAT	0.433		NaN											0	0	0	0.007291	0	25	13									
PCDHA11	56138	broad.mit.edu	37	5	140250447	140250447	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr5:140250447G>T	uc003lia.2	+	1	2617	c.1759G>T	c.(1759-1761)GGC>TGC	p.G587C	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc011dae.1_Missense_Mutation_p.G587C	NM_018902	NP_061725	Q9Y5I1	PCDAB_HUMAN	protocadherin alpha 11 isoform 1 precursor	587	Extracellular (Potential).|Cadherin 6.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			breast(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGTGGGTGCGGGCCACGTGGT	0.677		NaN											1	0	1.13719e-10	0.008361	1.30361e-10	22	95									
PCDH1	5097	broad.mit.edu	37	5	141233975	141233975	+	Missense_Mutation	SNP	T	T	C			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr5:141233975T>C	uc003llp.2	-	5	3463	c.3346A>G	c.(3346-3348)ATG>GTG	p.M1116V		NM_032420	NP_115796	Q08174	PCDH1_HUMAN	protocadherin 1 isoform 2 precursor	Error:Variant_position_missing_in_Q08174_after_alignment					cell-cell signaling|homophilic cell adhesion|nervous system development	cell-cell junction|integral to plasma membrane	calcium ion binding			ovary(5)	5		Lung NSC(810;0.027)|all_lung(500;0.0321)|all_hematologic(541;0.0433)|Prostate(461;0.0453)|Breast(839;0.128)|Lung SC(612;0.238)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)	GBM - Glioblastoma multiforme(465;1.06e-05)		GTGCCTGTCATGGCGACATCA	0.592		NaN											0	0	0	0.00245	0	10	39									
GABRG2	2566	broad.mit.edu	37	5	161569191	161569191	+	Missense_Mutation	SNP	T	T	C			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr5:161569191T>C	uc003lyz.3	+	7	1149	c.791T>C	c.(790-792)GTC>GCC	p.V264A	GABRG2_uc010jjc.2_Missense_Mutation_p.V304A|GABRG2_uc003lyy.3_Missense_Mutation_p.V264A|GABRG2_uc011dej.1_Missense_Mutation_p.V169A	NM_000816	NP_000807	P18507	GBRG2_HUMAN	gamma-aminobutyric acid A receptor, gamma 2	264	Extracellular (Probable).				gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity|protein binding			ovary(4)|skin(1)	5	Renal(175;0.000319)	Medulloblastoma(196;0.0208)|all_neural(177;0.0672)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0734)|OV - Ovarian serous cystadenocarcinoma(192;0.135)|Epithelial(171;0.136)		GTCATGTCTGTCTACTTTGAT	0.403		NaN											0	0	0	0.009535	0	24	144									
GABBR1	2550	broad.mit.edu	37	6	29598366	29598366	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr6:29598366G>A	uc003nmt.3	-	4	680	c.344C>T	c.(343-345)ACG>ATG	p.T115M	GABBR1_uc003nmp.3_5'Flank|GABBR1_uc003nms.3_5'Flank|GABBR1_uc003nmu.3_Intron|GABBR1_uc011dlr.1_Translation_Start_Site|GABBR1_uc011dls.1_Missense_Mutation_p.T115M	NM_001470	NP_001461	Q9UBS5	GABR1_HUMAN	gamma-aminobutyric acid (GABA) B receptor 1	115	Extracellular (Potential).|Sushi 2.				gamma-aminobutyric acid signaling pathway|negative regulation of adenylate cyclase activity|synaptic transmission	cell junction|extracellular region|integral to plasma membrane|postsynaptic membrane	G-protein coupled receptor activity|GABA-B receptor activity	p.T115M(1)		ovary(5)|liver(1)|skin(1)	7					Baclofen(DB00181)|Progabide(DB00837)	GTCCCCACCCGTCAGGAAAAC	0.562		NaN											0	0	0	0.00499	0	14	33									
SLC29A1	2030	broad.mit.edu	37	6	44197137	44197137	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr6:44197137G>C	uc003owu.1	+	3	369	c.40G>C	c.(40-42)GTC>CTC	p.V14L	SLC29A1_uc011dvp.1_Missense_Mutation_p.V33L|SLC29A1_uc003owv.1_Missense_Mutation_p.V14L|SLC29A1_uc003oww.1_Missense_Mutation_p.V93L|SLC29A1_uc011dvq.1_Missense_Mutation_p.V56L|SLC29A1_uc003owx.1_Missense_Mutation_p.V14L|SLC29A1_uc003owy.1_Missense_Mutation_p.V14L|SLC29A1_uc003owz.1_Missense_Mutation_p.V14L	NM_004955	NP_004946	Q99808	S29A1_HUMAN	equilibrative nucleoside transporter 1	14	Helical; (Potential).				nucleobase, nucleoside and nucleotide metabolic process	apical plasma membrane|basolateral plasma membrane|integral to plasma membrane|membrane fraction	nucleoside transmembrane transporter activity|protein binding			large_intestine(2)|skin(1)	3	all_cancers(18;3.19e-06)|Lung NSC(15;0.00108)|all_lung(25;0.00278)|Hepatocellular(11;0.00908)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)		Troglitazone(DB00197)	ATACAAAGCTGTCTGGCTTAT	0.562		NaN											0	0	0	0.009718	0	34	17									
CDC5L	988	broad.mit.edu	37	6	44361233	44361233	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr6:44361233G>A	uc003oxl.2	+	4	621	c.362G>A	c.(361-363)CGA>CAA	p.R121Q		NM_001253	NP_001244	Q99459	CDC5L_HUMAN	CDC5-like	121					cell cycle|regulation of transcription, DNA-dependent|transcription, DNA-dependent	catalytic step 2 spliceosome|cytoplasm|nuclear speck|nucleolus	DNA binding|RNA binding			lung(3)|ovary(1)|kidney(1)|skin(1)	6	all_lung(25;0.00433)|Ovarian(13;0.0273)|all_hematologic(164;0.208)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)			GATGATCCACGAAAACTTAAA	0.408		NaN											0	0	0	0.00308	0	7	18									
MDN1	23195	broad.mit.edu	37	6	90359913	90359913	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr6:90359913C>G	uc003pnn.1	-	97	16152	c.16036G>C	c.(16036-16038)GAC>CAC	p.D5346H		NM_014611	NP_055426	Q9NU22	MDN1_HUMAN	MDN1, midasin homolog	5346					protein complex assembly|regulation of protein complex assembly	nucleus	ATP binding|ATPase activity|unfolded protein binding			ovary(8)|skin(2)	10		all_cancers(76;1.47e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00246)		BRCA - Breast invasive adenocarcinoma(108;0.0193)		GTTCGATAGTCTCCTCTATTT	0.348		NaN											0	0	0	0.003163	0	12	1									
WISP3	8838	broad.mit.edu	37	6	112382385	112382385	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr6:112382385G>T	uc003pvm.2	+	3	350	c.240G>T	c.(238-240)AAG>AAT	p.K80N	WISP3_uc003pvn.2_RNA|WISP3_uc003pvo.2_Missense_Mutation_p.K98N	NM_003880	NP_003871	O95389	WISP3_HUMAN	WNT1 inducible signaling pathway protein 3	80	IGFBP N-terminal.				cell-cell signaling|regulation of cell growth|signal transduction	extracellular region|soluble fraction	growth factor activity|insulin-like growth factor binding				0		all_cancers(87;0.000196)|Acute lymphoblastic leukemia(125;1.18e-05)|all_hematologic(75;0.000114)|all_epithelial(87;0.00542)|Colorectal(196;0.0209)		all cancers(137;0.0283)|OV - Ovarian serous cystadenocarcinoma(136;0.0613)|Epithelial(106;0.0827)|GBM - Glioblastoma multiforme(226;0.0972)|BRCA - Breast invasive adenocarcinoma(108;0.246)		TCTGTGCCAAGCAACCAGGGG	0.537		NaN											1	0	6.4685e-43	0.01441	8.53987e-43	54	21									
GPRC6A	222545	broad.mit.edu	37	6	117128326	117128326	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr6:117128326C>T	uc003pxj.1	-	3	564	c.542G>A	c.(541-543)CGC>CAC	p.R181H	GPRC6A_uc003pxk.1_Missense_Mutation_p.R181H|GPRC6A_uc003pxl.1_Missense_Mutation_p.R181H	NM_148963	NP_683766	Q5T6X5	GPC6A_HUMAN	G protein-coupled receptor, family C, group 6,	181	Extracellular (Potential).				response to amino acid stimulus		G-protein coupled receptor activity			ovary(4)|skin(2)	6		all_cancers(87;0.0314)|all_epithelial(87;0.0216)|Colorectal(196;0.234)		GBM - Glioblastoma multiforme(226;0.0265)|all cancers(137;0.0554)|OV - Ovarian serous cystadenocarcinoma(136;0.07)		TGAAGGAAAGCGAATTTTGTC	0.398		NaN											0	0	0	0.01441	0	44	26									
CCDC28A	25901	broad.mit.edu	37	6	139097341	139097341	+	Silent	SNP	C	C	A			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr6:139097341C>A	uc003qie.2	+	2	509	c.354C>A	c.(352-354)GCC>GCA	p.A118A	uc003qid.1_5'Flank	NM_015439	NP_056254	Q8IWP9	CC28A_HUMAN	coiled-coil domain containing 28A	118											0				OV - Ovarian serous cystadenocarcinoma(155;0.000201)|GBM - Glioblastoma multiforme(68;0.000306)		AAAAAAATGCCATTCCAGTGA	0.388		NaN											1	0	2.77807e-22	0.013114	3.58707e-22	40	10									
SYNE1	23345	broad.mit.edu	37	6	152464820	152464820	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr6:152464820C>T	uc010kiw.2	-	138	25659	c.25057G>A	c.(25057-25059)GAA>AAA	p.E8353K	SYNE1_uc010kiv.2_Missense_Mutation_p.E2877K|SYNE1_uc003qos.3_Missense_Mutation_p.E2877K|SYNE1_uc003qot.3_Missense_Mutation_p.E8305K|SYNE1_uc003qou.3_Missense_Mutation_p.E8353K|SYNE1_uc003qop.3_Missense_Mutation_p.E538K|SYNE1_uc011eez.1_Missense_Mutation_p.E555K|SYNE1_uc003qoq.3_Missense_Mutation_p.E555K|SYNE1_uc003qor.3_Missense_Mutation_p.E1276K	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	8353	Potential.|Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		ATGATATTTTCGGTTTGCTGT	0.532		NaN								HNSCC(10;0.0054)			0	0	0	0.012319	0	19	52									
MACC1	346389	broad.mit.edu	37	7	20199459	20199459	+	Silent	SNP	C	C	T			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr7:20199459C>T	uc003sus.3	-	5	834	c.525G>A	c.(523-525)CGG>CGA	p.R175R	MACC1_uc010kug.2_Silent_p.R175R	NM_182762	NP_877439	Q6ZN28	MACC1_HUMAN	putative binding protein 7a5	175					positive regulation of cell division|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	growth factor activity			ovary(2)|skin(1)	3						TATAAGCCTCCCGATCATTTT	0.468		NaN											0	0	0	0.004482	0	8	68									
DNAH11	8701	broad.mit.edu	37	7	21631013	21631013	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr7:21631013C>T	uc003svc.2	+	14	2516	c.2485C>T	c.(2485-2487)CGC>TGC	p.R829C		NM_003777	NP_003768	Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	829	Stem (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(8)|large_intestine(3)|pancreas(3)|central_nervous_system(1)	15						CAGAGTTGAGCGCACACAGAA	0.607		NaN							Kartagener_syndrome				0	0	0	0.00499	0	14	33									
C7orf30	115416	broad.mit.edu	37	7	23347511	23347511	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr7:23347511G>T	uc003swd.1	+	3	492	c.460G>T	c.(460-462)GAC>TAC	p.D154Y	C7orf30_uc003swe.2_5'Flank	NM_138446	NP_612455	Q96EH3	CG030_HUMAN	hypothetical protein LOC115416	154						mitochondrion					0			GBM - Glioblastoma multiforme(13;0.154)			ATGTAAACGTGACCCTCATGT	0.428		NaN											1	0	9.68594e-22	0.01441	1.23038e-21	49	81									
MUC17	140453	broad.mit.edu	37	7	100678782	100678782	+	Missense_Mutation	SNP	T	T	C			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr7:100678782T>C	uc003uxp.1	+	3	4138	c.4085T>C	c.(4084-4086)GTT>GCT	p.V1362A	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	1362	Extracellular (Potential).|20.|59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					ACAACTCCTGTTGACAACAGC	0.453		NaN											0	0	0	0.01441	0	169	238									
SYPL1	6856	broad.mit.edu	37	7	105732326	105732326	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr7:105732326C>A	uc003vdp.2	-	6	787	c.705G>T	c.(703-705)GAG>GAT	p.E235D	SYPL1_uc003vdo.2_Missense_Mutation_p.E217D	NM_006754	NP_006745	Q16563	SYPL1_HUMAN	synaptophysin-like 1 isoform a	235	Cytoplasmic (Potential).|MARVEL.				synaptic transmission	cytoplasmic vesicle membrane|integral to plasma membrane|melanosome|synaptic vesicle	transporter activity				0						GTAGGCTGGTCTCCTTGTACA	0.383		NaN											1	0	2.38262e-10	0.010771	2.69191e-10	35	39									
FLNC	2318	broad.mit.edu	37	7	128471003	128471003	+	Silent	SNP	C	C	G			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr7:128471003C>G	uc003vnz.3	+	1	521	c.312C>G	c.(310-312)CTC>CTG	p.L104L	FLNC_uc003voa.3_Silent_p.L104L	NM_001458	NP_001449	Q14315	FLNC_HUMAN	gamma filamin isoform a	104	CH 1.|Actin-binding.				cell junction assembly	cytoskeleton|cytosol|plasma membrane|sarcomere	actin binding			breast(5)|large_intestine(3)|ovary(2)|central_nervous_system(1)|skin(1)	12						CCGTGGCCCTCGAGTTCCTCG	0.657		NaN											0	0	0	0.007835	0	32	37									
DGKI	9162	broad.mit.edu	37	7	137271869	137271869	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr7:137271869G>T	uc003vtt.2	-	13	1400	c.1399C>A	c.(1399-1401)CTG>ATG	p.L467M	DGKI_uc003vtu.2_Missense_Mutation_p.L167M	NM_004717	NP_004708	O75912	DGKI_HUMAN	diacylglycerol kinase, iota	467	DAGKc.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	nucleus|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			ovary(1)|kidney(1)|skin(1)	3						GTTCGAGCCAGGTCATTCCCA	0.552		NaN											1	0	7.7325e-45	0.01441	1.03246e-44	46	81									
RP1L1	94137	broad.mit.edu	37	8	10469938	10469938	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr8:10469938C>T	uc003wtc.2	-	4	1899	c.1670G>A	c.(1669-1671)GGC>GAC	p.G557D		NM_178857	NP_849188	Q8IWN7	RP1L1_HUMAN	retinitis pigmentosa 1-like 1	557					intracellular signal transduction					ovary(4)|breast(3)|central_nervous_system(1)	8				COAD - Colon adenocarcinoma(149;0.0811)		CCTTGCCTTGCCTGGACAGCC	0.657		NaN											0	0	0	0.004656	0	24	39									
GATA4	2626	broad.mit.edu	37	8	11615912	11615912	+	Silent	SNP	G	G	A			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr8:11615912G>A	uc003wuc.2	+	7	1811	c.1257G>A	c.(1255-1257)CAG>CAA	p.Q419Q	GATA4_uc003wub.1_Silent_p.Q213Q|GATA4_uc011kxc.1_Silent_p.Q420Q|uc003wud.1_5'Flank	NM_002052	NP_002043	P43694	GATA4_HUMAN	GATA binding protein 4	419					atrial septum primum morphogenesis|atrial septum secundum morphogenesis|blood coagulation|cardiac right ventricle morphogenesis|cell-cell signaling|embryonic foregut morphogenesis|embryonic heart tube anterior/posterior pattern formation|endocardial cushion development|endoderm development|heart looping|intestinal epithelial cell differentiation|male gonad development|positive regulation of angiogenesis|positive regulation of cardioblast differentiation|positive regulation of transcription from RNA polymerase II promoter|positive regulation vascular endothelial growth factor production|response to drug|transcription from RNA polymerase II promoter|ventricular septum development	nucleoplasm	activating transcription factor binding|sequence-specific DNA binding|transcription regulatory region DNA binding|zinc ion binding			central_nervous_system(1)	1	all_epithelial(15;0.0839)		STAD - Stomach adenocarcinoma(15;0.00225)	COAD - Colon adenocarcinoma(149;0.199)		AGTCTCCACAGACCAGCTCCA	0.587		NaN											0	0	0	0.013726	0	27	47									
TNFRSF10D	8793	broad.mit.edu	37	8	23004489	23004489	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr8:23004489C>T	uc003xcz.1	-	4	559	c.467G>A	c.(466-468)CGG>CAG	p.R156Q		NM_003840	NP_003831	Q9UBN6	TR10D_HUMAN	tumor necrosis factor receptor superfamily,	156	Extracellular (Potential).|TNFR-Cys 3.				anti-apoptosis|apoptosis	integral to membrane	TRAIL binding|transmembrane receptor activity				0		Prostate(55;0.0421)|Breast(100;0.067)		Colorectal(74;0.0147)|COAD - Colon adenocarcinoma(73;0.0612)		TCTACACGTCCGGCACATCTC	0.502		NaN											0	0	0	0.006214	0	7	44									
ADAM32	203102	broad.mit.edu	37	8	39111966	39111966	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr8:39111966C>A	uc003xmt.3	+	18	2181	c.1936C>A	c.(1936-1938)CCA>ACA	p.P646T	ADAM32_uc011lch.1_Missense_Mutation_p.P547T|ADAM32_uc003xmu.3_Missense_Mutation_p.P540T|ADAM32_uc003xmv.2_Missense_Mutation_p.P70T	NM_145004	NP_659441	Q8TC27	ADA32_HUMAN	a disintegrin and metalloprotease domain 32	646	EGF-like.|Extracellular (Potential).				proteolysis	integral to membrane	metalloendopeptidase activity|zinc ion binding			ovary(1)|lung(1)|kidney(1)	3		all_cancers(7;3e-05)|all_lung(54;0.00187)|Hepatocellular(245;0.00745)|Lung NSC(58;0.00771)|Breast(189;0.0503)	LUSC - Lung squamous cell carcinoma(45;6.2e-07)|Colorectal(1;0.00699)|READ - Rectum adenocarcinoma(1;0.146)			CCATTGTTCGCCAGGCTATAA	0.363		NaN											1	0	0.00621372	0.006214	0.00637652	6	3									
PLAT	5327	broad.mit.edu	37	8	42050684	42050684	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr8:42050684C>G	uc003xos.2	-	2	229	c.20G>C	c.(19-21)GGG>GCG	p.G7A	PLAT_uc010lxf.1_Missense_Mutation_p.G7A|PLAT_uc010lxg.1_Missense_Mutation_p.G7A|PLAT_uc003xot.2_Missense_Mutation_p.G7A|PLAT_uc011lcm.1_Missense_Mutation_p.G7A|PLAT_uc011lcn.1_Missense_Mutation_p.G7A	NM_000930	NP_000921	P00750	TPA_HUMAN	plasminogen activator, tissue isoform 1	7					blood coagulation|fibrinolysis|negative regulation of proteolysis|protein modification process|proteolysis	cell surface|cytoplasm|extracellular space	protein binding|serine-type endopeptidase activity			breast(1)|skin(1)	2	all_cancers(6;3.84e-26)|all_epithelial(6;9.61e-28)|all_lung(13;7.2e-13)|Lung NSC(13;1.18e-11)|Ovarian(28;0.00438)|Prostate(17;0.0119)|Colorectal(14;0.0468)|Lung SC(25;0.211)	all_lung(54;0.000378)|Lung NSC(58;0.00145)|Hepatocellular(245;0.0524)|Renal(179;0.0822)|Esophageal squamous(32;0.0954)	BRCA - Breast invasive adenocarcinoma(8;5.23e-10)|OV - Ovarian serous cystadenocarcinoma(14;0.00135)|Colorectal(10;0.00165)|Lung(22;0.00467)|COAD - Colon adenocarcinoma(11;0.0171)|LUSC - Lung squamous cell carcinoma(45;0.024)		Alteplase(DB00009)|Aminocaproic Acid(DB00513)|Anistreplase(DB00029)|Iloprost(DB01088)|Reteplase(DB00015)|Tenecteplase(DB00031)|Tranexamic Acid(DB00302)|Urokinase(DB00013)	ACAGCAGAGCCCTCTCTTCAT	0.547		NaN											0	0	0	0.003163	0	12	28									
ZFHX4	79776	broad.mit.edu	37	8	77764038	77764038	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr8:77764038G>T	uc003yav.2	+	10	5133	c.4746G>T	c.(4744-4746)GAG>GAT	p.E1582D	ZFHX4_uc003yau.1_Missense_Mutation_p.E1627D|ZFHX4_uc003yaw.1_Missense_Mutation_p.E1582D	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	1582						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			CAAAGCTGGAGCCCAGTGGTC	0.517		NaN								HNSCC(33;0.089)			1	0	1.67942e-08	0.006122	1.87935e-08	15	20									
FAM83H	286077	broad.mit.edu	37	8	144810312	144810312	+	Missense_Mutation	SNP	T	T	G			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr8:144810312T>G	uc003yzk.2	-	5	1388	c.1319A>C	c.(1318-1320)GAC>GCC	p.D440A	FAM83H_uc010mfk.1_RNA	NM_198488	NP_940890	Q6ZRV2	FA83H_HUMAN	FAM83H	440					biomineral tissue development					lung(1)|central_nervous_system(1)|pancreas(1)	3	all_cancers(97;3.74e-11)|all_epithelial(106;2.62e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;3.38e-41)|Epithelial(56;6.8e-40)|all cancers(56;6.43e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.146)			GAAGCGGAAGTCGTCGCCGTG	0.697		NaN											0	0	0	0.000602	0	5	15									
CNTLN	54875	broad.mit.edu	37	9	17466040	17466040	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr9:17466040G>T	uc003zmz.2	+	22	3616	c.3590G>T	c.(3589-3591)AGA>ATA	p.R1197I	CNTLN_uc003zmy.2_Missense_Mutation_p.R1198I|CNTLN_uc010mio.2_Missense_Mutation_p.R877I	NM_017738	NP_060208	Q9NXG0	CNTLN_HUMAN	centlein isoform 1	1198	Potential.					centriole|membrane	two-component sensor activity			pancreas(1)	1				GBM - Glioblastoma multiforme(50;6.14e-10)		CTAAAGCAAAGACTTAACGTT	0.303		NaN											1	0	4.74835e-14	0.010818	5.63567e-14	27	27									
AUH	549	broad.mit.edu	37	9	94118381	94118381	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr9:94118381G>C	uc004arf.3	-	2	354	c.319C>G	c.(319-321)CTT>GTT	p.L107V	AUH_uc004arg.3_Missense_Mutation_p.L107V|AUH_uc011ltu.1_Missense_Mutation_p.L107V	NM_001698	NP_001689	Q13825	AUHM_HUMAN	AU RNA binding protein/enoyl-Coenzyme A	107	RNA-binding.				branched chain family amino acid catabolic process|mRNA catabolic process	mitochondrial matrix	enoyl-CoA hydratase activity|methylglutaconyl-CoA hydratase activity|mRNA 3'-UTR binding				0						ATTTTTATAAGATTTTTACTG	0.289		NaN											0	0	0	0.009096	0	4	17									
C9orf5	23731	broad.mit.edu	37	9	111849557	111849557	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr9:111849557C>T	uc004bdt.3	-	6	1248	c.1216G>A	c.(1216-1218)GTG>ATG	p.V406M	C9orf5_uc004bds.3_RNA|C9orf5_uc004bdr.3_Missense_Mutation_p.V406M	NM_032012	NP_114401	Q9H330	CI005_HUMAN	hypothetical protein LOC23731	406						integral to membrane				central_nervous_system(1)	1		Myeloproliferative disorder(63;0.204)		OV - Ovarian serous cystadenocarcinoma(323;3.08e-05)|STAD - Stomach adenocarcinoma(157;0.0823)		CCCCACCACACATGGTAGCGT	0.413		NaN											0	0	0	0.004656	0	21	30									
RXRA	6256	broad.mit.edu	37	9	137328351	137328351	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq;WGS			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr9:137328351C>T	uc004cfb.2	+	10	1442	c.1280C>T	c.(1279-1281)TCC>TTC	p.S427F	RXRA_uc004cfc.1_Missense_Mutation_p.S330F	NM_002957	NP_002948	P19793	RXRA_HUMAN	retinoid X receptor, alpha	427	Ligand-binding.				cellular lipid metabolic process|cholesterol metabolic process|interspecies interaction between organisms|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to retinoic acid|vitamin metabolic process	nuclear chromatin|nucleoplasm	enzyme binding|ligand-regulated transcription factor activity|protein heterodimerization activity|retinoic acid-responsive element binding|retinoid-X receptor activity|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|transcription coactivator activity|vitamin D receptor binding|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)	2				OV - Ovarian serous cystadenocarcinoma(145;4.66e-08)|Epithelial(140;6.72e-08)|all cancers(34;2.22e-07)	Acitretin(DB00459)|Adapalene(DB00210)|Alitretinoin(DB00523)|Etretinate(DB00926)	GCTCTGCGCTCCATCGGGCTC	0.607		NaN											0	0	0	0.006122	0	17	55									
SHROOM2	357	broad.mit.edu	37	X	9900619	9900619	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chrX:9900619C>T	uc004csu.1	+	6	3386	c.3296C>T	c.(3295-3297)CCT>CTT	p.P1099L	SHROOM2_uc004csv.2_5'UTR|SHROOM2_uc011mic.1_5'UTR|SHROOM2_uc004csw.1_5'UTR	NM_001649	NP_001640	Q13796	SHRM2_HUMAN	apical protein of Xenopus-like	1099					apical protein localization|brain development|cell migration|cell morphogenesis|cellular pigment accumulation|ear development|establishment of melanosome localization|eye pigment granule organization|lens morphogenesis in camera-type eye|melanosome organization	apical plasma membrane|cell-cell adherens junction|microtubule|tight junction	actin filament binding|beta-catenin binding|ligand-gated sodium channel activity			ovary(3)|skin(3)|upper_aerodigestive_tract(1)|breast(1)	8		Hepatocellular(5;0.000888)				ACGCCATCCCCTGCGTCCCTG	0.692		NaN											0	0	0	0.001984	0	6	52									
DMD	1756	broad.mit.edu	37	X	32383166	32383166	+	Silent	SNP	G	G	T			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chrX:32383166G>T	uc004dda.1	-	35	5240	c.4996C>A	c.(4996-4998)CGA>AGA	p.R1666R	DMD_uc004dcw.2_Silent_p.R322R|DMD_uc004dcx.2_Silent_p.R325R|DMD_uc004dcz.2_Silent_p.R1543R|DMD_uc004dcy.1_Silent_p.R1662R|DMD_uc004ddb.1_Silent_p.R1658R|DMD_uc010ngo.1_Intron	NM_004006	NP_003997	P11532	DMD_HUMAN	dystrophin Dp427m isoform	1666	Spectrin 11.|Interaction with SYNM (By similarity).				muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			ovary(3)|pancreas(2)|large_intestine(1)	6		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				TCTTCTGCTCGGGAGGTGACA	0.428		NaN											1	0	3.30226e-22	0.01441	4.24061e-22	49	44									
CXorf22	170063	broad.mit.edu	37	X	35993361	35993361	+	Silent	SNP	G	G	A			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chrX:35993361G>A	uc004ddj.2	+	14	2411	c.2352G>A	c.(2350-2352)CAG>CAA	p.Q784Q	CXorf22_uc010ngv.2_Splice_Site	NM_152632	NP_689845	Q6ZTR5	CX022_HUMAN	hypothetical protein LOC170063	784										large_intestine(1)|lung(1)|ovary(1)	3						TTTTGCTCCAGTTAGATACTG	0.358		NaN											0	0	0	0.01441	0	90	83									
HDAC6	10013	broad.mit.edu	37	X	48682372	48682372	+	Missense_Mutation	SNP	A	A	G			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chrX:48682372A>G	uc011mmi.1	+	27	3439	c.3344A>G	c.(3343-3345)CAT>CGT	p.H1115R	HDAC6_uc004dks.1_Missense_Mutation_p.H1115R|HDAC6_uc010nig.1_Missense_Mutation_p.H963R|HDAC6_uc004dkt.1_Missense_Mutation_p.H1115R|HDAC6_uc011mmk.1_Missense_Mutation_p.H1096R|HDAC6_uc004dkv.1_Missense_Mutation_p.H763R|HDAC6_uc004dkw.1_Missense_Mutation_p.H763R|HDAC6_uc004dkx.1_Missense_Mutation_p.H478R	NM_006044	NP_006035	Q9UBN7	HDAC6_HUMAN	histone deacetylase 6	1115		Zinc 1.			aggresome assembly|cellular response to hydrogen peroxide|Hsp90 deacetylation|lysosome localization|macroautophagy|misfolded or incompletely synthesized protein catabolic process|negative regulation of proteolysis|negative regulation of transcription, DNA-dependent|peptidyl-lysine deacetylation|polyubiquitinated misfolded protein transport|positive regulation of apoptosis|positive regulation of cellular chaperone-mediated protein complex assembly|positive regulation of epithelial cell migration|positive regulation of receptor biosynthetic process|positive regulation of signal transduction|regulation of androgen receptor signaling pathway|regulation of receptor activity|response to growth factor stimulus|response to toxin|transcription, DNA-dependent|tubulin deacetylation	aggresome|caveola|cell leading edge|cytosol|histone deacetylase complex|microtubule associated complex|perinuclear region of cytoplasm	actin binding|alpha-tubulin binding|beta-catenin binding|dynein complex binding|histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|Hsp90 protein binding|microtubule binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|polyubiquitin binding|tau protein binding|tubulin deacetylase activity|zinc ion binding			ovary(3)|upper_aerodigestive_tract(1)	4					Vorinostat(DB02546)	TGGTGTCCCCATTTGGTGGCA	0.517		NaN											0	0	0	0.007835	0	34	86									
PJA1	64219	broad.mit.edu	37	X	68382762	68382762	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chrX:68382762G>A	uc004dxh.2	-	2	606	c.320C>T	c.(319-321)TCG>TTG	p.S107L	PJA1_uc011mpi.1_5'UTR|PJA1_uc004dxg.2_Intron|PJA1_uc004dxi.2_Missense_Mutation_p.S52L	NM_145119	NP_660095	Q8NG27	PJA1_HUMAN	praja 1 isoform a	107							zinc ion binding				0						TCTGCTACCCGAAGCTCTGTA	0.522		NaN											0	0	0	0.014323	0	20	99									
OGT	8473	broad.mit.edu	37	X	70775117	70775117	+	Missense_Mutation	SNP	A	A	G			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chrX:70775117A>G	uc004eaa.1	+	7	1023	c.806A>G	c.(805-807)TAC>TGC	p.Y269C	BCYRN1_uc011mpt.1_Intron|OGT_uc004eab.1_Missense_Mutation_p.Y259C|OGT_uc004eac.2_Missense_Mutation_p.Y130C|OGT_uc004ead.2_Intron	NM_181672	NP_858058	O15294	OGT1_HUMAN	O-linked GlcNAc transferase isoform 1	269	TPR 7.				cellular response to retinoic acid|positive regulation of granulocyte differentiation|positive regulation of histone H3-K4 methylation|positive regulation of proteolysis|protein O-linked glycosylation|signal transduction	cytosol|MLL5-L complex	enzyme activator activity|protein binding|protein N-acetylglucosaminyltransferase activity			ovary(3)|kidney(1)|pancreas(1)	5	Renal(35;0.156)					GCTTGTGTATACTATGAGCAA	0.453		NaN											0	0	0	0.01441	0	64	72									
PSMD10	5716	broad.mit.edu	37	X	107331994	107331994	+	Silent	SNP	A	A	G			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chrX:107331994A>G	uc004enp.1	-	2	299	c.201T>C	c.(199-201)AAT>AAC	p.N67N	ATG4A_uc004enr.2_5'Flank|ATG4A_uc004ent.2_5'Flank|ATG4A_uc004ens.2_5'Flank|ATG4A_uc011msl.1_5'Flank|ATG4A_uc010npi.2_5'Flank|PSMD10_uc004enq.1_Silent_p.N67N|PSMD10_uc010nph.1_Silent_p.N67N	NM_002814	NP_002805	O75832	PSD10_HUMAN	proteasome 26S non-ATPase subunit 10 isoform 1	67	Interaction with RELA.|ANK 2.|Interaction with RB1.				anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|cytoplasmic sequestering of NF-kappaB|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of apoptosis|negative regulation of DNA damage response, signal transduction by p53 class mediator|negative regulation of MAPKKK cascade|negative regulation of NF-kappaB transcription factor activity|negative regulation of release of cytochrome c from mitochondria|negative regulation of transcription from RNA polymerase II promoter|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of cell growth|positive regulation of cyclin-dependent protein kinase activity|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|proteasome regulatory particle assembly|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	actin cytoskeleton|cytoplasm|intermediate filament cytoskeleton|nucleus|proteasome regulatory particle	transcription factor binding			ovary(1)	1						CGTCTTTATCATTCACTGGCA	0.413		NaN											0	0	0	0.01441	0	212	193									
COL4A5	1287	broad.mit.edu	37	X	107938638	107938638	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chrX:107938638C>A	uc004enz.1	+	51	5165	c.4963C>A	c.(4963-4965)CTG>ATG	p.L1655M	COL4A5_uc011mso.1_Missense_Mutation_p.L1652M|COL4A5_uc011msp.1_Missense_Mutation_p.L331M	NM_033380	NP_203699	P29400	CO4A5_HUMAN	type IV collagen alpha 5 isoform 2 precursor	1649	Collagen IV NC1.		L -> R (in APSX; adult type).|Missing (in APSX).		axon guidance	collagen type IV	extracellular matrix structural constituent|protein binding			ovary(3)|central_nervous_system(1)	4						CAGCTTTTGGCTGGCAACTGT	0.463		NaN							Alport_syndrome_with_Diffuse_Leiomyomatosis				1	0	4.02486e-48	0.01441	5.40481e-48	54	68									
KLHL13	90293	broad.mit.edu	37	X	117054334	117054334	+	Splice_Site	SNP	C	C	A			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chrX:117054334C>A	uc004eql.2	-	3	303	c.241_splice	c.e3-1	p.G81_splice	KLHL13_uc004eqk.2_Splice_Site_p.G30_splice|KLHL13_uc011mtn.1_Splice_Site|KLHL13_uc011mto.1_Splice_Site_p.G75_splice|KLHL13_uc011mtp.1_Splice_Site_p.G83_splice|KLHL13_uc004eqm.2_Splice_Site_p.G30_splice|KLHL13_uc011mtq.1_Splice_Site_p.G65_splice	NM_033495	NP_277030	Q9P2N7	KLH13_HUMAN	kelch-like 13						cytokinesis|mitosis|protein ubiquitination	Cul3-RING ubiquitin ligase complex				kidney(1)|skin(1)	2						GGTCAAAGCCCTACAACAAGA	0.408		NaN											1	0	3.94638e-17	0.01441	4.7804e-17	46	49									
THOC2	57187	broad.mit.edu	37	X	122754808	122754808	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chrX:122754808G>A	uc004etu.2	-	32	4257	c.4225C>T	c.(4225-4227)CGC>TGC	p.R1409C	THOC2_uc010nqt.1_RNA|THOC2_uc004etw.1_Missense_Mutation_p.R230C	NM_001081550	NP_001075019	Q8NI27	THOC2_HUMAN	THO complex 2	1409	Lys-rich.				intronless viral mRNA export from host nucleus|mRNA processing|RNA splicing	THO complex part of transcription export complex	protein binding|RNA binding			ovary(3)	3						ATTTTGCGGCGTTTTTGTTCT	0.398		NaN											0	0	0	0.01441	0	147	118									
FRMD7	90167	broad.mit.edu	37	X	131233527	131233527	+	Silent	SNP	C	C	T			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chrX:131233527C>T	uc004ewn.2	-	3	352	c.174G>A	c.(172-174)GAG>GAA	p.E58E	FRMD7_uc011muy.1_Silent_p.E58E	NM_194277	NP_919253	Q6ZUT3	FRMD7_HUMAN	FERM domain containing 7	58	FERM.				regulation of neuron projection development	cytoskeleton|growth cone|neuronal cell body	binding			skin(1)	1	Acute lymphoblastic leukemia(192;0.000127)					GCTTCAAAAGCTCCAGCCAAA	0.343		NaN											0	0	0	0.01441	0	50	117									
PLXNB3	5365	broad.mit.edu	37	X	153038980	153038980	+	Nonsense_Mutation	SNP	C	C	T			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chrX:153038980C>T	uc004fii.2	+	19	3265	c.3091C>T	c.(3091-3093)CGA>TGA	p.R1031*	PLXNB3_uc010nuk.2_Nonsense_Mutation_p.R1054*|PLXNB3_uc011mzd.1_Nonsense_Mutation_p.R670*|PLXNB3_uc004fij.1_5'Flank|SRPK3_uc004fik.2_5'Flank	NM_005393	NP_005384	Q9ULL4	PLXB3_HUMAN	plexin B3 isoform 1	1031	IPT/TIG 3.|Extracellular (Potential).				axon guidance	integral to membrane|intracellular|plasma membrane	protein binding|receptor activity			lung(1)	1	all_hematologic(71;4.25e-06)|all_lung(58;3.83e-05)|Lung NSC(58;5.54e-05)|Acute lymphoblastic leukemia(192;6.56e-05)					CAGGGGTGGGCGACTGATCCG	0.687		NaN											0	0	0	0.009718	0	36	28									
FAM43B	163933	broad.mit.edu	37	1	20880268	20880270	+	In_Frame_Del	DEL	GAG	GAG	-			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr1:20880268_20880270delGAG	uc001bdj.2	+	1	1337_1339	c.802_804delGAG	c.(802-804)GAGdel	p.E272del		NM_207334	NP_997217	Q6ZT52	FA43B_HUMAN	family with sequence similarity 43, member B	272											0		Colorectal(325;0.000147)|Renal(390;0.000469)|Lung NSC(340;0.00412)|all_lung(284;0.00419)|Breast(348;0.00979)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0427)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|COAD - Colon adenocarcinoma(152;1.11e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000132)|Kidney(64;0.00016)|GBM - Glioblastoma multiforme(114;0.000399)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.195)		ggaggaggacgaggaggaggagg	0.567		NaN											NaN	NaN	NaN	NaN	NaN	7	11	---	---							
GRHL3	57822	broad.mit.edu	37	1	24663111	24663112	+	Frame_Shift_Ins	INS	-	-	A			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr1:24663111_24663112insA	uc001biy.2	+	4	467_468	c.421_422insA	c.(421-423)GAGfs	p.E141fs	GRHL3_uc001bix.2_Frame_Shift_Ins_p.E136fs|GRHL3_uc001biz.2_Frame_Shift_Ins_p.E43fs	NM_021180	NP_067003	Q8TE85	GRHL3_HUMAN	sister-of-mammalian grainyhead protein isoform	136					regulation of actin cytoskeleton organization|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(1)	1		Colorectal(325;3.46e-05)|Renal(390;0.0007)|Lung NSC(340;0.00171)|all_lung(284;0.00226)|Ovarian(437;0.00348)|Breast(348;0.0126)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.19)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;8.72e-25)|Colorectal(126;4.38e-08)|COAD - Colon adenocarcinoma(152;1.84e-06)|GBM - Glioblastoma multiforme(114;0.000132)|BRCA - Breast invasive adenocarcinoma(304;0.00105)|STAD - Stomach adenocarcinoma(196;0.00151)|KIRC - Kidney renal clear cell carcinoma(1967;0.00377)|READ - Rectum adenocarcinoma(331;0.0656)|Lung(427;0.143)		GATGAGCTTGGAGGGGGCCTTG	0.579		NaN											NaN	NaN	NaN	NaN	NaN	27	85	---	---							
PVRL1	5818	broad.mit.edu	37	11	119549465	119549466	+	Frame_Shift_Ins	INS	-	-	GA			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr11:119549465_119549466insGA	uc001pwv.2	-	2	261_262	c.89_90insTC	c.(88-90)TCCfs	p.S30fs	PVRL1_uc001pwu.1_Frame_Shift_Ins_p.S30fs|PVRL1_uc001pww.2_Frame_Shift_Ins_p.S30fs	NM_002855	NP_002846	Q15223	PVRL1_HUMAN	poliovirus receptor-related 1 isoform 1	30					adherens junction organization|cell junction assembly|entry of virus into host cell|heterophilic cell-cell adhesion|homophilic cell adhesion|immune response	cell-cell adherens junction|extracellular region|integral to membrane	cell adhesion molecule binding|coreceptor activity|protein homodimerization activity				0		Breast(348;0.037)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;4.29e-05)		GGACCACCTGGGAGTGGACGCC	0.594		NaN											NaN	NaN	NaN	NaN	NaN	6	12	---	---							
DIS3	22894	broad.mit.edu	37	13	73337684	73337684	+	Frame_Shift_Del	DEL	T	T	-			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr13:73337684delT	uc001vix.3	-	16	2406	c.2032delA	c.(2032-2034)ATTfs	p.I678fs	DIS3_uc001viy.3_Frame_Shift_Del_p.I648fs|DIS3_uc001viz.2_RNA	NM_014953	NP_055768	Q9Y2L1	RRP44_HUMAN	DIS3 mitotic control isoform a	678					CUT catabolic process|exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|rRNA catabolic process|rRNA processing	cytosol|exosome (RNase complex)|nucleolus|nucleoplasm	3'-5'-exoribonuclease activity|endonuclease activity|guanyl-nucleotide exchange factor activity|protein binding|RNA binding			central_nervous_system(1)	1		Breast(118;0.0074)|Acute lymphoblastic leukemia(28;0.0195)		GBM - Glioblastoma multiforme(99;0.000181)		TCCTCATGAATTTTTTTTGCA	0.358		NaN								Multiple Myeloma(4;0.011)			NaN	NaN	NaN	NaN	NaN	7	76	---	---							
CX3CL1	6376	broad.mit.edu	37	16	57416702	57416708	+	Frame_Shift_Del	DEL	ACCATGG	ACCATGG	-			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr16:57416702_57416708delACCATGG	uc002eli.2	+	3	1019_1025	c.952_958delACCATGG	c.(952-960)ACCATGGACfs	p.T318fs		NM_002996	NP_002987	P78423	X3CL1_HUMAN	chemokine (C-X3-C motif) ligand 1 precursor	318_320	Mucin-like stalk.|Extracellular (Potential).				cell adhesion|cytokine-mediated signaling pathway|defense response|immune response|leukocyte adhesive activation|positive regulation of calcium-independent cell-cell adhesion|positive regulation of inflammatory response	cell surface|extracellular space|integral to membrane|plasma membrane	chemokine activity				0						CATCCATGCCACCATGGACCCCCAGAG	0.662		NaN											NaN	NaN	NaN	NaN	NaN	17	72	---	---							
NKG7	4818	broad.mit.edu	37	19	51875242	51875244	+	In_Frame_Del	DEL	AGG	AGG	-			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr19:51875242_51875244delAGG	uc002pwj.2	-	3	560_562	c.389_391delCCT	c.(388-393)TCCTGG>TGG	p.S130del	CLDND2_uc002pwi.1_5'Flank|NKG7_uc002pwk.2_In_Frame_Del_p.S95del	NM_005601	NP_005592	Q16617	NKG7_HUMAN	natural killer cell group 7 sequence	130						integral to plasma membrane				central_nervous_system(1)	1		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000211)|OV - Ovarian serous cystadenocarcinoma(262;0.00979)		TAGAAGGACCAGGAGAAGAAGGT	0.611		NaN											NaN	NaN	NaN	NaN	NaN	26	74	---	---							
WDFY3	23001	broad.mit.edu	37	4	85611708	85611709	+	Frame_Shift_Del	DEL	CA	CA	-			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr4:85611708_85611709delCA	uc003hpd.2	-	61	9721_9722	c.9313_9314delTG	c.(9313-9315)TGGfs	p.W3105fs		NM_014991	NP_055806	Q8IZQ1	WDFY3_HUMAN	WD repeat and FYVE domain containing 3 isoform	3105	WD 1.					cytoplasmic part|extrinsic to membrane|nuclear envelope	1-phosphatidylinositol binding|metal ion binding|protein binding			ovary(2)|central_nervous_system(1)	3		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000808)		GCCCATCTCCCACACACACACA	0.51		NaN											NaN	NaN	NaN	NaN	NaN	7	114	---	---							
KDM3B	51780	broad.mit.edu	37	5	137722024	137722028	+	Frame_Shift_Del	DEL	GGACT	GGACT	-			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr5:137722024_137722028delGGACT	uc003lcy.1	+	7	1294_1298	c.1094_1098delGGACT	c.(1093-1098)AGGACTfs	p.R365fs	KDM3B_uc010jew.1_Frame_Shift_Del_p.R21fs|KDM3B_uc011cys.1_5'UTR	NM_016604	NP_057688	Q7LBC6	KDM3B_HUMAN	jumonji domain containing 1B	365_366					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			ovary(3)|upper_aerodigestive_tract(2)|lung(2)|kidney(2)|central_nervous_system(1)|skin(1)	11						GAAAACGGCAGGACTCTGGTGGTGC	0.551		NaN											NaN	NaN	NaN	NaN	NaN	64	150	---	---							
RUFY1	80230	broad.mit.edu	37	5	178977642	178977642	+	Frame_Shift_Del	DEL	G	G	-			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr5:178977642delG	uc003mka.1	+	1	72	c.72delG	c.(70-72)CCGfs	p.P24fs		NM_025158	NP_079434	Q96T51	RUFY1_HUMAN	RUN and FYVE domain-containing 1 isoform a	24					endocytosis|protein transport	early endosome membrane	lipid binding|zinc ion binding			ovary(4)|breast(1)	5	all_cancers(89;0.00018)|all_epithelial(37;8.37e-05)|Renal(175;0.000159)|Lung NSC(126;0.00108)|all_lung(126;0.00195)	all_cancers(40;0.0322)|Medulloblastoma(196;0.00498)|all_neural(177;0.0138)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			agccggggccggggcCCGGGT	0.512		NaN								HNSCC(44;0.11)			NaN	NaN	NaN	NaN	NaN	2	4	---	---							
GDF6	392255	broad.mit.edu	37	8	97157110	97157111	+	Frame_Shift_Ins	INS	-	-	A			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr8:97157110_97157111insA	uc003yhp.2	-	2	1148_1149	c.1048_1049insT	c.(1048-1050)TCCfs	p.S350fs		NM_001001557	NP_001001557	Q6KF10	GDF6_HUMAN	growth differentiation factor 6 precursor	350					activin receptor signaling pathway|BMP signaling pathway|growth|pathway-restricted SMAD protein phosphorylation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of transcription, DNA-dependent	extracellular space	cytokine activity|growth factor activity			ovary(1)|breast(1)|pancreas(1)	3	Breast(36;2.67e-05)					GCGTAGCCTGGACTTCTTGCCG	0.515		NaN											NaN	NaN	NaN	NaN	NaN	8	13	---	---							
NTRK2	4915	broad.mit.edu	37	9	87356831	87356837	+	Frame_Shift_Del	DEL	TAATTTA	TAATTTA	-			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr9:87356831_87356837delTAATTTA	uc004aoa.1	+	12	2122_2128	c.1184_1190delTAATTTA	c.(1183-1191)GTAATTTATfs	p.V395fs	NTRK2_uc004anv.1_Frame_Shift_Del_p.V382fs|NTRK2_uc004any.1_Frame_Shift_Del_p.V395fs|NTRK2_uc004anz.1_Frame_Shift_Del_p.V395fs|NTRK2_uc011lsz.1_Frame_Shift_Del_p.V395fs|NTRK2_uc011lta.1_Frame_Shift_Del_p.V395fs|NTRK2_uc004aob.1_Frame_Shift_Del_p.V395fs|NTRK2_uc011ltb.1_Frame_Shift_Del_p.V239fs	NM_001018064	NP_001018074	Q16620	NTRK2_HUMAN	neurotrophic tyrosine kinase, receptor, type 2	395_397	Extracellular (Potential).				activation of adenylate cyclase activity|cell differentiation|nerve growth factor receptor signaling pathway|nervous system development	integral to plasma membrane	ATP binding|neurotrophin receptor activity|transmembrane receptor protein tyrosine kinase activity			lung(11)|central_nervous_system(1)|breast(1)|skin(1)|ovary(1)|liver(1)	16						TATCCTGATGTAATTTATGAAGGTAGC	0.309		NaN								TSP Lung(25;0.17)			NaN	NaN	NaN	NaN	NaN	7	19	---	---							
DDX26B	203522	broad.mit.edu	37	X	134680317	134680317	+	Frame_Shift_Del	DEL	T	T	-			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chrX:134680317delT	uc004eyw.3	+	4	715	c.352delT	c.(352-354)TTTfs	p.F118fs		NM_182540	NP_872346	Q5JSJ4	DX26B_HUMAN	DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide	118	VWFA.										0	Acute lymphoblastic leukemia(192;6.56e-05)					GAGAAATCCATTTTTTTTAGA	0.269		NaN											NaN	NaN	NaN	NaN	NaN	34	41	---	---							
CD99L2	83692	broad.mit.edu	37	X	149984524	149984526	+	In_Frame_Del	DEL	GTG	GTG	-			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chrX:149984524_149984526delGTG	uc004fel.2	-	3	274_276	c.156_158delCAC	c.(154-159)ACCACA>ACA	p.52_53TT>T	CD99L2_uc004fek.2_5'Flank|CD99L2_uc004fem.2_Intron|CD99L2_uc004fen.2_Intron|CD99L2_uc004feo.2_RNA|CD99L2_uc011myb.1_In_Frame_Del_p.52_53TT>T	NM_031462	NP_113650	Q8TCZ2	C99L2_HUMAN	CD99 antigen-like 2 isoform E3'-E4'-E3-E4	52_53	Extracellular (Potential).|Poly-Thr.				cell adhesion	cell junction|integral to membrane				large_intestine(2)|ovary(1)	3	Acute lymphoblastic leukemia(192;6.56e-05)					CCTATTGGTTGTGGTGGTGGTGG	0.552		NaN											NaN	NaN	NaN	NaN	NaN	7	457	---	---