Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	isArtifactMode	oxoGCut	pox	pox_cutoff	qox	t_alt_count	t_ref_count	validation_alt_allele	validation_tumor_sample							
AGRN	375790	broad.mit.edu	37	1	957650	957650	+	Missense_Mutation	SNP	A	A	G			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr1:957650A>G	uc001ack.1	+	2	321	c.271A>G	c.(271-273)AAG>GAG	p.K91E		NM_198576	NP_940978	O00468	AGRIN_HUMAN	agrin precursor	91	NtA.				axon guidance|clustering of voltage-gated sodium channels|muscarinic acetylcholine receptor signaling pathway|receptor clustering	basal lamina	laminin binding|structural constituent of cytoskeleton			central_nervous_system(2)|breast(1)	3	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		UCEC - Uterine corpus endometrioid carcinoma (11;0.00462)|Epithelial(90;5.98e-38)|OV - Ovarian serous cystadenocarcinoma(86;5.43e-23)|Colorectal(212;5.97e-05)|COAD - Colon adenocarcinoma(227;0.000201)|Kidney(185;0.0024)|BRCA - Breast invasive adenocarcinoma(365;0.00246)|STAD - Stomach adenocarcinoma(132;0.00645)|KIRC - Kidney renal clear cell carcinoma(229;0.0354)|Lung(427;0.201)		CGGCGGCAACAAGGTGGTGAT	0.602		NaN											0	0	0	0.235728	0	37	78									
GJB4	127534	broad.mit.edu	37	1	35227230	35227230	+	Silent	SNP	C	C	T	rs147830069		TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr1:35227230C>T	uc001bxv.1	+	2	745	c.375C>T	c.(373-375)GGC>GGT	p.G125G	GJB4_uc001bxw.3_Silent_p.G125G	NM_153212	NP_694944	Q9NTQ9	CXB4_HUMAN	gap junction protein, beta 4	125	Cytoplasmic (Potential).				cell communication	connexon complex|integral to membrane	gap junction channel activity			ovary(2)|central_nervous_system(1)	3		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.234)				AGAAGCGGGGCGGACTGTGGT	0.592		NaN											0	0	0	0.132662	0	14	28									
OXCT2	64064	broad.mit.edu	37	1	40236123	40236123	+	Missense_Mutation	SNP	C	C	T			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr1:40236123C>T	uc001ceb.1	-	1	898	c.805G>A	c.(805-807)GTG>ATG	p.V269M	BMP8B_uc001cdz.1_Intron|BMP8B_uc001cea.1_Intron|OXCT2_uc009vvu.1_Missense_Mutation_p.V263M	NM_022120	NP_071403	Q9BYC2	SCOT2_HUMAN	3-oxoacid CoA transferase 2 precursor	269					ketone body catabolic process	microtubule-based flagellum|mitochondrion	3-oxoacid CoA-transferase activity			pancreas(1)	1	all_cancers(7;5.56e-14)|all_lung(5;3.88e-17)|all_epithelial(6;3.78e-16)|Lung NSC(20;7.03e-07)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0393)	OV - Ovarian serous cystadenocarcinoma(33;1.87e-18)|Epithelial(16;1.92e-17)|all cancers(16;4.03e-16)|LUSC - Lung squamous cell carcinoma(16;0.000261)|Lung(16;0.000457)		Succinic acid(DB00139)	CCCTTTATCACGCGATCTACA	0.532		NaN									OREG0013400	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.234183	0	22	107									
PRPF38B	55119	broad.mit.edu	37	1	109242068	109242068	+	Missense_Mutation	SNP	G	G	A			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr1:109242068G>A	uc001dvv.3	+	6	1349	c.1067G>A	c.(1066-1068)AGA>AAA	p.R356K	PRPF38B_uc001dvw.3_Missense_Mutation_p.R245K|PRPF38B_uc010ouz.1_Missense_Mutation_p.R159K	NM_018061	NP_060531	Q5VTL8	PR38B_HUMAN	PRP38 pre-mRNA processing factor 38 (yeast)	356	Arg-rich.				mRNA processing|RNA splicing	spliceosomal complex					0		all_epithelial(167;0.000154)|all_lung(203;0.00026)|Lung NSC(277;0.000508)		Colorectal(144;0.0149)|Lung(183;0.0888)|COAD - Colon adenocarcinoma(174;0.113)|Epithelial(280;0.161)		gatcgagaaagagagaaagaa	0.219		NaN											0	0	0	0.038147	0	8	26									
RSBN1	54665	broad.mit.edu	37	1	114340631	114340631	+	Missense_Mutation	SNP	T	T	C			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr1:114340631T>C	uc001edq.2	-	2	767	c.731A>G	c.(730-732)CAG>CGG	p.Q244R	RSBN1_uc001edr.2_RNA	NM_018364	NP_060834	Q5VWQ0	RSBN1_HUMAN	round spermatid basic protein 1	244						nucleus				ovary(1)	1	Lung SC(450;0.184)	all_cancers(81;3.78e-08)|all_epithelial(167;5.56e-08)|all_lung(203;6.97e-06)|Lung NSC(69;1.18e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		ATCGGCTCTCTGGGTTTTACC	0.358		NaN											0	0	0	0.11126	0	44	71									
ADAM30	11085	broad.mit.edu	37	1	120438648	120438648	+	Silent	SNP	A	A	T			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr1:120438648A>T	uc001eij.2	-	1	466	c.312T>A	c.(310-312)CCT>CCA	p.P104P		NM_021794	NP_068566	Q9UKF2	ADA30_HUMAN	ADAM metallopeptidase domain 30 preproprotein	104					proteolysis	integral to membrane	metalloendopeptidase activity|zinc ion binding	p.P104L(1)		ovary(2)|lung(1)	3	all_cancers(5;7.07e-10)|all_epithelial(5;1.62e-10)|all_neural(166;0.153)|Breast(55;0.234)	all_lung(203;1.55e-06)|Lung NSC(69;1.04e-05)|all_epithelial(167;0.00138)		Lung(183;0.0204)|LUSC - Lung squamous cell carcinoma(189;0.117)		TTGGTATGTAAGGATGATCCT	0.502		NaN											0	0	0	0.153744	0	33	35									
PDE4DIP	9659	broad.mit.edu	37	1	144922560	144922560	+	Missense_Mutation	SNP	T	T	C			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr1:144922560T>C	uc001elw.3	-	7	1138	c.847A>G	c.(847-849)ATT>GTT	p.I283V	NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|PDE4DIP_uc001elk.1_Intron|PDE4DIP_uc001ell.1_Intron|PDE4DIP_uc001elm.3_Intron|PDE4DIP_uc001eln.3_Intron|PDE4DIP_uc001elo.2_Intron|PDE4DIP_uc001elx.3_Missense_Mutation_p.I349V|PDE4DIP_uc001emc.1_Missense_Mutation_p.I283V|PDE4DIP_uc001emd.1_Missense_Mutation_p.I283V|PDE4DIP_uc001emb.1_Missense_Mutation_p.I446V|PDE4DIP_uc001eme.1_5'Flank|PDE4DIP_uc001emf.1_Missense_Mutation_p.I70V	NM_014644	NP_055459	Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein isoform	283	Potential.				cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			ovary(4)|haematopoietic_and_lymphoid_tissue(1)	5				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		AGGTTCTGAATTGTACCATCT	0.388		NaN	T	PDGFRB	MPD								0	0	0	0.139131	0	48	383									
S100A5	6276	broad.mit.edu	37	1	153509783	153509783	+	Missense_Mutation	SNP	C	C	T			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr1:153509783C>T	uc001fbx.2	-	4	550	c.322G>A	c.(322-324)GAC>AAC	p.D108N	S100A6_uc001fbw.1_5'Flank	NM_002962	NP_002953	P33763	S10A5_HUMAN	S100 calcium binding protein A5	90						nucleus	calcium ion binding|copper ion binding|protein homodimerization activity|zinc ion binding				0	all_lung(78;5.98e-32)|Lung NSC(65;2.27e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.171)			CACTTGTTGTCCTCTAGAAAG	0.582		NaN											0	0	0	0.134883	0	31	33									
ATF6	22926	broad.mit.edu	37	1	161771931	161771931	+	Missense_Mutation	SNP	G	G	A			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr1:161771931G>A	uc001gbr.2	+	7	845	c.778G>A	c.(778-780)GGG>AGG	p.G260R	ATF6_uc001gbq.1_Missense_Mutation_p.G260R	NM_007348	NP_031374	P18850	ATF6A_HUMAN	activating transcription factor 6	260	Cytoplasmic (Potential).				positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response|protein folding	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|nuclear envelope|nucleoplasm	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			ovary(2)|skin(1)	3	all_hematologic(112;0.156)		BRCA - Breast invasive adenocarcinoma(70;0.00953)			TGCTGTTGCTGGGGGAGTCAC	0.532		NaN											0	0	0	0.108266	0	23	71									
VAMP4	8674	broad.mit.edu	37	1	171707494	171707494	+	Missense_Mutation	SNP	C	C	T			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr1:171707494C>T	uc001ghx.1	-	2	275	c.61G>A	c.(61-63)GAA>AAA	p.E21K	VAMP4_uc001ghw.1_RNA|VAMP4_uc001ghy.1_Missense_Mutation_p.E21K	NM_003762	NP_003753	O75379	VAMP4_HUMAN	vesicle-associated membrane protein 4	21	Cytoplasmic (Potential).				vesicle-mediated transport	endosome|Golgi membrane|integral to membrane|lysosome					0	all_cancers(6;1.42e-10)|all_hematologic(923;0.088)|Acute lymphoblastic leukemia(37;0.181)					CTTACCCTTTCACTTTTCACA	0.318		NaN											0	0	0	0.038147	0	6	27									
LOC642587	642587	broad.mit.edu	37	1	209602671	209602671	+	Missense_Mutation	SNP	A	A	T			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr1:209602671A>T	uc009xcn.2	+	2	412	c.29A>T	c.(28-30)CAA>CTA	p.Q10L	LOC642587_uc010psk.1_5'Flank|MIR205_hsa-mir-205|MI0000285_5'Flank	NM_001104548	NP_001098018			hypothetical protein LOC642587												0				OV - Ovarian serous cystadenocarcinoma(81;0.0422)		GAGAGAAATCAACTATTCAGG	0.284		NaN											0	0	0	0.115264	0	2	4									
DISP1	84976	broad.mit.edu	37	1	223116445	223116445	+	Missense_Mutation	SNP	C	C	T			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr1:223116445C>T	uc001hnu.1	+	2	427	c.280C>T	c.(280-282)CAT>TAT	p.H94Y		NM_032890	NP_116279	Q96F81	DISP1_HUMAN	dispatched A	94					diaphragm development|protein homotrimerization|regulation of protein secretion|smoothened signaling pathway	basolateral plasma membrane|integral to membrane	hedgehog receptor activity|peptide transporter activity				0				GBM - Glioblastoma multiforme(131;0.102)		TTTGACTAGCCATAGCAGTCA	0.532		NaN											0	0	0	0.144211	0	29	94									
LYST	1130	broad.mit.edu	37	1	235884187	235884187	+	Missense_Mutation	SNP	G	G	C			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr1:235884187G>C	uc001hxj.2	-	40	9509	c.9334C>G	c.(9334-9336)CAC>GAC	p.H3112D	LYST_uc001hxi.2_Missense_Mutation_p.H336D	NM_000081	NP_000072	Q99698	LYST_HUMAN	lysosomal trafficking regulator	3112					defense response to bacterium|defense response to protozoan|defense response to virus|endosome to lysosome transport via multivesicular body sorting pathway|leukocyte chemotaxis|mast cell secretory granule organization|melanosome organization|natural killer cell mediated cytotoxicity|protein transport	cytoplasm|microtubule cytoskeleton	protein binding			ovary(6)|breast(4)|central_nervous_system(2)	12	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.00246)|Prostate(94;0.0771)|Acute lymphoblastic leukemia(190;0.228)	OV - Ovarian serous cystadenocarcinoma(106;0.000674)			AGTATATTGTGGTATACATCA	0.338		NaN							Chediak-Higashi_syndrome				0	0	0	0.219247	0	21	91									
AHCTF1	25909	broad.mit.edu	37	1	247025300	247025300	+	Silent	SNP	T	T	A			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr1:247025300T>A	uc001ibu.1	-	27	3703	c.3696A>T	c.(3694-3696)TCA>TCT	p.S1232S	AHCTF1_uc001ibv.1_Silent_p.S1241S|AHCTF1_uc009xgs.1_Silent_p.S93S|AHCTF1_uc001ibw.1_RNA	NM_015446	NP_056261	Q8WYP5	ELYS_HUMAN	transcription factor ELYS	1232	Necessary for nuclear localization (By similarity).				cytokinesis|mitotic prometaphase|mRNA transport|nuclear pore complex assembly|protein transport|transmembrane transport	condensed chromosome kinetochore|cytosol|nuclear matrix|nuclear membrane|nuclear pore|nucleoplasm	DNA binding			ovary(5)|skin(2)	7	all_cancers(71;3.05e-05)|all_epithelial(71;6.72e-06)|Ovarian(71;0.0173)|Breast(184;0.0318)|all_lung(81;0.0458)|Lung NSC(105;0.0518)	all_cancers(173;0.0266)	OV - Ovarian serous cystadenocarcinoma(106;0.00271)			CTTCCACAAATGAAATTCTAG	0.398		NaN											0	0	0	0.234183	0	21	21									
ARMC3	219681	broad.mit.edu	37	10	23326230	23326230	+	Missense_Mutation	SNP	C	C	G			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr10:23326230C>G	uc001irm.3	+	19	2524	c.2441C>G	c.(2440-2442)TCC>TGC	p.S814C	ARMC3_uc010qcv.1_Missense_Mutation_p.S807C|ARMC3_uc010qcw.1_Missense_Mutation_p.S551C	NM_173081	NP_775104	Q5W041	ARMC3_HUMAN	armadillo repeat containing 3	814							binding				0						ATTGGTTGCTCCCTAGTTCGC	0.532		NaN											0	0	0	0.116897	0	26	59									
BAMBI	25805	broad.mit.edu	37	10	28970934	28970934	+	Missense_Mutation	SNP	T	T	A			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr10:28970934T>A	uc001iuj.1	+	3	790	c.387T>A	c.(385-387)CAT>CAA	p.H129Q	BAMBI_uc001iui.2_3'UTR	NM_012342	NP_036474	Q13145	BAMBI_HUMAN	BMP and activin membrane-bound inhibitor	129	Extracellular (Potential).				cell migration|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of catenin import into nucleus|positive regulation of cell proliferation|positive regulation of epithelial to mesenchymal transition|positive regulation of protein binding|positive regulation of transcription, DNA-dependent|regulation of cell shape	cytoplasm|integral to membrane|plasma membrane	frizzled binding|type II transforming growth factor beta receptor binding			central_nervous_system(4)	4						GGTATCAGCATGATGGTAGCA	0.453		NaN											0	0	0	0.214465	0	38	67									
ZNF37A	7587	broad.mit.edu	37	10	38407014	38407014	+	Nonsense_Mutation	SNP	C	C	G			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr10:38407014C>G	uc001izk.2	+	8	1754	c.935C>G	c.(934-936)TCA>TGA	p.S312*	ZNF37A_uc001izl.2_Nonsense_Mutation_p.S312*|ZNF37A_uc001izm.2_Nonsense_Mutation_p.S312*	NM_001007094	NP_001007095	P17032	ZN37A_HUMAN	zinc finger protein 37a	312	C2H2-type 4.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)	1						TATAAGAATTCAGACCTCATT	0.423		NaN											0	0	0	0.193644	0	36	76									
MYOZ1	58529	broad.mit.edu	37	10	75391746	75391746	+	Missense_Mutation	SNP	G	G	A			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr10:75391746G>A	uc001jur.2	-	6	1207	c.842C>T	c.(841-843)CCT>CTT	p.P281L		NM_021245	NP_067068	Q9NP98	MYOZ1_HUMAN	myozenin 1	281					myofibril assembly	nucleus|pseudopodium	FATZ binding			ovary(2)	2	Prostate(51;0.0112)					GTAGTCTACAGGCTCCCCAGA	0.532		NaN											0	0	0	0.204396	0	21	32									
RNLS	55328	broad.mit.edu	37	10	90034726	90034726	+	Missense_Mutation	SNP	G	G	A			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr10:90034726G>A	uc001kfd.2	-	7	1075	c.940C>T	c.(940-942)CCC>TCC	p.P314S	RNLS_uc010qms.1_Missense_Mutation_p.P231S	NM_018363	NP_060833	Q5VYX0	RNLS_HUMAN	renalase isoform 2	Error:Variant_position_missing_in_Q5VYX0_after_alignment						extracellular region	oxidoreductase activity			ovary(1)	1						AGTCAGATGGGAAATCCAATC	0.348		NaN											0	0	0	0.069234	0	10	40									
SORBS1	10580	broad.mit.edu	37	10	97141472	97141472	+	Silent	SNP	G	G	T			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr10:97141472G>T	uc001kkp.2	-	16	1668	c.1623C>A	c.(1621-1623)GGC>GGA	p.G541G	SORBS1_uc001kkk.2_Silent_p.G119G|SORBS1_uc001kkl.2_Silent_p.G143G|SORBS1_uc001kkn.2_Silent_p.G328G|SORBS1_uc001kkm.2_Silent_p.G397G|SORBS1_uc001kko.2_Silent_p.G563G|SORBS1_uc001kkq.2_Silent_p.G426G|SORBS1_uc001kkr.2_Silent_p.G331G|SORBS1_uc001kks.2_Silent_p.G331G|SORBS1_uc001kkt.2_RNA|SORBS1_uc001kku.2_Silent_p.G372G|SORBS1_uc001kkv.2_Silent_p.G463G|SORBS1_uc001kkw.2_Silent_p.G495G|SORBS1_uc010qoe.1_Silent_p.G340G|SORBS1_uc010qof.1_Silent_p.G693G	NM_001034954	NP_001030126	Q9BX66	SRBS1_HUMAN	sorbin and SH3 domain containing 1 isoform 3	541					focal adhesion assembly|glucose transport|insulin receptor signaling pathway|muscle contraction|positive regulation of establishment of protein localization in plasma membrane|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of lipid biosynthetic process|stress fiber assembly	centrosome|cytosol|focal adhesion|membrane raft|nucleus|stress fiber|zonula adherens	actin binding|insulin receptor binding|SH3/SH2 adaptor activity			breast(1)	1		Colorectal(252;0.0429)		Epithelial(162;1.7e-06)|all cancers(201;6.52e-05)		CGGAAGACTTGCCAGGCTGAT	0.403		NaN											1	0	2.32078e-09	0.132662	2.50046e-09	14	79									
PPRC1	23082	broad.mit.edu	37	10	103907098	103907098	+	Missense_Mutation	SNP	C	C	T			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr10:103907098C>T	uc001kum.2	+	9	4388	c.4349C>T	c.(4348-4350)TCA>TTA	p.S1450L	PPRC1_uc001kun.2_Missense_Mutation_p.S1330L|PPRC1_uc010qqj.1_Intron|PPRC1_uc009xxa.2_Intron	NM_015062	NP_055877	Q5VV67	PPRC1_HUMAN	peroxisome proliferator-activated receptor	1450	Arg-rich.|Necessary for interaction with CREB1 and NRF1.|Ser-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleotide binding|RNA binding			ovary(1)|central_nervous_system(1)|skin(1)	3		Colorectal(252;0.122)		Epithelial(162;4.97e-08)|all cancers(201;8.99e-07)		TCGTCTTCCTCATCCCGATCT	0.597		NaN											0	0	0	0.193644	0	34	22									
HRAS	3265	broad.mit.edu	37	11	533875	533875	+	Missense_Mutation	SNP	G	G	T	rs28933406		TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08			G	T	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq;WGS			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr11:533875G>T	uc001lpv.2	-	3	369	c.181C>A	c.(181-183)CAG>AAG	p.Q61K	HRAS_uc010qvw.1_Missense_Mutation_p.Q61K|HRAS_uc010qvx.1_Missense_Mutation_p.Q61K|HRAS_uc010qvy.1_RNA	NM_005343	NP_005334	P01112	RASH_HUMAN	v-Ha-ras Harvey rat sarcoma viral oncogene	61	GTP.		Q -> L (in melanoma; strongly reduced GTP hydrolysis in the presence of RAF1; increases transformation of cultured cell lines).	Q->V: Strongly increased transformation of cultured cell lines.|Q->I: Moderately increased transformation of cultured cell lines.	activation of MAPKK activity|axon guidance|blood coagulation|cell cycle arrest|cellular senescence|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|mitotic cell cycle G1/S transition checkpoint|negative regulation of cell proliferation|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of DNA replication|positive regulation of epithelial cell proliferation|Ras protein signal transduction|synaptic transmission	cytosol|Golgi membrane|plasma membrane	GTP binding|GTPase activity|protein C-terminus binding	p.Q61R(112)|p.Q61L(91)|p.Q61K(39)|p.Q61H(20)|p.Q61P(3)|p.Q61Q(1)|p.Q61E(1)		urinary_tract(174)|thyroid(155)|skin(126)|upper_aerodigestive_tract(112)|soft_tissue(37)|prostate(29)|salivary_gland(24)|cervix(23)|stomach(14)|pituitary(10)|lung(9)|haematopoietic_and_lymphoid_tissue(9)|breast(6)|testis(5)|endometrium(4)|bone(3)|large_intestine(2)|oesophagus(2)|penis(2)|kidney(1)|adrenal_gland(1)|thymus(1)	749		all_cancers(49;4.37e-09)|all_epithelial(84;2.09e-06)|Breast(177;0.000162)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.0538)|all_lung(207;0.0713)		all cancers(45;7.63e-28)|Epithelial(43;7.29e-27)|OV - Ovarian serous cystadenocarcinoma(40;7.15e-21)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0375)|LUSC - Lung squamous cell carcinoma(625;0.0703)	Sulindac(DB00605)	TACTCCTCCTGGCCGGCGGTA	0.597		6	Mis		infrequent sarcomas|rare other types	rhadomyosarcoma|ganglioneuroblastoma|bladder			Costello_syndrome	HNSCC(11;0.0054)			1	0	5.20837e-25	0.268233	5.91699e-25	41	42									
BRSK2	9024	broad.mit.edu	37	11	1463777	1463777	+	Silent	SNP	C	C	T			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr11:1463777C>T	uc001lti.2	+	5	857	c.471C>T	c.(469-471)ATC>ATT	p.I157I	BRSK2_uc009ycv.1_Silent_p.I157I|BRSK2_uc001lth.1_Silent_p.I157I|BRSK2_uc001ltj.2_Silent_p.I157I|BRSK2_uc001ltk.2_RNA|BRSK2_uc001ltl.2_Silent_p.I157I|BRSK2_uc001ltm.2_Silent_p.I203I|BRSK2_uc001ltn.2_RNA|BRSK2_uc010qwx.1_RNA	NM_003957	NP_003948	Q8IWQ3	BRSK2_HUMAN	BR serine/threonine kinase 2	157	Protein kinase.				establishment of cell polarity|neuron differentiation		ATP binding|magnesium ion binding|protein serine/threonine kinase activity				0		all_epithelial(84;4.17e-05)|Breast(177;0.000307)|Ovarian(85;0.0014)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00144)|Lung(200;0.0713)|LUSC - Lung squamous cell carcinoma(625;0.0842)		ACATCCGCATCGCAGACTTTG	0.622		NaN											0	0	0	0.204396	0	19	9									
OR56B4	196335	broad.mit.edu	37	11	6129922	6129922	+	Missense_Mutation	SNP	T	T	A			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr11:6129922T>A	uc010qzx.1	+	1	914	c.914T>A	c.(913-915)CTG>CAG	p.L305Q		NM_001005181	NP_001005181	Q8NH76	O56B4_HUMAN	olfactory receptor, family 56, subfamily B,	305	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;1.31e-08)|BRCA - Breast invasive adenocarcinoma(625;0.135)		AAACTCAGACTGGGCTTTCAG	0.488		NaN											0	0	0	0.139131	0	57	51									
PC	5091	broad.mit.edu	37	11	66636412	66636412	+	Silent	SNP	G	G	C			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr11:66636412G>C	uc001ojn.1	-	8	976	c.927C>G	c.(925-927)ACC>ACG	p.T309T	PC_uc001ojo.1_Silent_p.T309T|PC_uc001ojp.1_Silent_p.T309T	NM_022172	NP_071504	P11498	PYC_HUMAN	pyruvate carboxylase precursor	309	ATP-grasp.|Biotin carboxylation.				gluconeogenesis|lipid biosynthetic process	mitochondrial matrix	ATP binding|biotin binding|biotin carboxylase activity|metal ion binding|pyruvate carboxylase activity			ovary(2)|lung(1)|kidney(1)	4		Melanoma(852;0.0525)		Lung(977;0.153)|LUSC - Lung squamous cell carcinoma(976;0.227)	Biotin(DB00121)|Pyruvic acid(DB00119)	GGAACTCCACGGTGCCTGCGT	0.637		NaN											0	0	0	0.219247	0	17	49									
KBTBD3	143879	broad.mit.edu	37	11	105923955	105923955	+	Silent	SNP	A	A	G			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr11:105923955A>G	uc001pja.2	-	4	2101	c.1461T>C	c.(1459-1461)TCT>TCC	p.S487S	KBTBD3_uc001pjb.2_Silent_p.S487S|KBTBD3_uc009yxm.2_Silent_p.S408S	NM_198439	NP_940841	Q8NAB2	KBTB3_HUMAN	BTB and kelch domain containing 3	483	Kelch 4.									ovary(1)|central_nervous_system(1)	2		Melanoma(852;0.000878)|Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0017)|Breast(348;0.0321)		BRCA - Breast invasive adenocarcinoma(274;5.43e-05)|Epithelial(105;0.00418)|all cancers(92;0.0299)		CTACTAGTTCAGACCACTGAT	0.348		NaN											0	0	0	0.204396	0	21	8									
ATM	472	broad.mit.edu	37	11	108115703	108115703	+	Missense_Mutation	SNP	A	A	C			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08			A	C	A	A		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq;WGS			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr11:108115703A>C	uc001pkb.1	+	7	1236	c.851A>C	c.(850-852)CAA>CCA	p.Q284P	ATM_uc009yxr.1_Missense_Mutation_p.Q284P	NM_000051	NP_000042	Q13315	ATM_HUMAN	ataxia telangiectasia mutated isoform 1	284					cell cycle arrest|cellular response to gamma radiation|DNA damage induced protein phosphorylation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|double-strand break repair via homologous recombination|G2/M transition DNA damage checkpoint|histone mRNA catabolic process|mitotic cell cycle spindle assembly checkpoint|negative regulation of B cell proliferation|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|pre-B cell allelic exclusion|protein autophosphorylation|reciprocal meiotic recombination|replicative senescence	cytoplasmic membrane-bounded vesicle|nucleoplasm	1-phosphatidylinositol-3-kinase activity|ATP binding|DNA binding|DNA-dependent protein kinase activity|identical protein binding|protein complex binding|protein dimerization activity|protein N-terminus binding			haematopoietic_and_lymphoid_tissue(174)|lung(25)|breast(15)|large_intestine(9)|ovary(5)|kidney(5)|central_nervous_system(4)|upper_aerodigestive_tract(1)|stomach(1)|NS(1)	240		all_cancers(61;9.64e-12)|all_epithelial(67;9.97e-08)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		Epithelial(105;9.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.06e-05)|all cancers(92;0.000208)|Colorectal(284;0.116)|OV - Ovarian serous cystadenocarcinoma(223;0.147)		GAATTATTTCAACTGCAAATT	0.308		NaN	D|Mis|N|F|S		T-PLL	leukemia|lymphoma|medulloblastoma|glioma		Genes_defective_in_diseases_associated_with_sensitivity_to_DNA_damaging_agents	Ataxia_Telangiectasia	TSP Lung(14;0.12)			0	0	0	0.234183	0	22	20									
LRTM2	654429	broad.mit.edu	37	12	1940432	1940432	+	Silent	SNP	G	G	A			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr12:1940432G>A	uc001qjt.2	+	4	1205	c.399G>A	c.(397-399)AGG>AGA	p.R133R	CACNA2D4_uc001qjp.2_Intron|CACNA2D4_uc009zds.1_Intron|CACNA2D4_uc009zdt.1_Intron|CACNA2D4_uc009zdr.1_Intron|LRTM2_uc001qju.2_Silent_p.R133R|LRTM2_uc010sdx.1_Silent_p.R133R|LRTM2_uc001qjv.2_Intron	NM_001039029	NP_001034118	Q8N967	LRTM2_HUMAN	leucine-rich repeats and transmembrane domains 2	133	Extracellular (Potential).|LRR 3.					integral to membrane				large_intestine(1)	1	Ovarian(42;0.107)		OV - Ovarian serous cystadenocarcinoma(31;0.000834)			CCCTGGACAGGGACCTGCTGC	0.637		NaN									OREG0005740	type=TRANSCRIPTION FACTOR BINDING SITE|Gene=CACNA2D4|TFbs=REST|Dataset=NRSF/REST ChIPSeq sites|EvidenceSubtype=Chromatin immunoprecipitation with tag sequencing (ChIP-TS)	0	0	0	0.09319	0	12	61									
KCNA1	3736	broad.mit.edu	37	12	5020962	5020962	+	Nonsense_Mutation	SNP	G	G	T			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr12:5020962G>T	uc001qnh.2	+	2	1523	c.418G>T	c.(418-420)GAG>TAG	p.E140*		NM_000217	NP_000208	Q09470	KCNA1_HUMAN	potassium voltage-gated channel subfamily A	140					synaptic transmission	juxtaparanode region of axon|voltage-gated potassium channel complex	delayed rectifier potassium channel activity|potassium ion transmembrane transporter activity			ovary(1)|skin(1)	2					Desflurane(DB01189)|Enflurane(DB00228)|Isoflurane(DB00753)|Methoxyflurane(DB01028)|Sevoflurane(DB01236)	CATCAAGGAGGAGGAGCGCCC	0.627		NaN											1	0	7.05477e-17	0.160694	7.90702e-17	18	45									
PIK3C2G	5288	broad.mit.edu	37	12	18644430	18644430	+	Missense_Mutation	SNP	G	G	A			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr12:18644430G>A	uc001rdt.2	+	19	2724	c.2608G>A	c.(2608-2610)GAT>AAT	p.D870N	PIK3C2G_uc010sia.1_RNA|PIK3C2G_uc010sib.1_Missense_Mutation_p.D911N|PIK3C2G_uc010sic.1_Missense_Mutation_p.D689N	NM_004570	NP_004561	O75747	P3C2G_HUMAN	phosphoinositide-3-kinase, class 2 gamma	870					cell communication|phosphatidylinositol-mediated signaling	membrane|phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity			lung(8)|central_nervous_system(6)|breast(3)|stomach(2)|ovary(2)	21		Hepatocellular(102;0.194)				GTTCTTTCAAGATGTAAATAC	0.333		NaN											0	0	0	0.11911	0	12	59									
COL2A1	1280	broad.mit.edu	37	12	48375154	48375154	+	Missense_Mutation	SNP	G	G	A			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr12:48375154G>A	uc001rqu.2	-	37	2616	c.2435C>T	c.(2434-2436)GCA>GTA	p.A812V	COL2A1_uc009zkw.2_RNA|COL2A1_uc001rqv.2_Missense_Mutation_p.A743V	NM_001844	NP_001835	P02458	CO2A1_HUMAN	collagen, type II, alpha 1 isoform 1 precursor	812	Triple-helical region.				axon guidance|collagen fibril organization|embryonic skeletal joint morphogenesis|sensory perception of sound|visual perception	collagen type II	identical protein binding|platelet-derived growth factor binding			ovary(1)|skin(1)	2		Acute lymphoblastic leukemia(13;0.108)|all_hematologic(14;0.214)			Collagenase(DB00048)	AGCACTTCCTGCAGGACCAGG	0.637		NaN											0	0	0	0.184627	0	4	9									
RARG	5916	broad.mit.edu	37	12	53607337	53607337	+	Missense_Mutation	SNP	G	G	C			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr12:53607337G>C	uc001sce.2	-	8	1446	c.961C>G	c.(961-963)CTG>GTG	p.L321V	RARG_uc001scd.2_Missense_Mutation_p.L310V|RARG_uc010sob.1_Missense_Mutation_p.L299V|RARG_uc001scf.2_Missense_Mutation_p.L321V|RARG_uc001scg.2_Missense_Mutation_p.L249V|RARG_uc010soc.1_Missense_Mutation_p.L200V|RARG_uc010sod.1_Missense_Mutation_p.L358V	NM_000966	NP_000957	P13631	RARG_HUMAN	retinoic acid receptor, gamma isoform 1	321	Ligand-binding.				canonical Wnt receptor signaling pathway|embryonic eye morphogenesis|embryonic hindlimb morphogenesis|negative regulation of cell proliferation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of apoptosis|positive regulation of transcription from RNA polymerase II promoter|regulation of cell size|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to retinoic acid	integral to membrane|transcription factor complex	retinoic acid receptor activity|retinoid X receptor binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			breast(2)|ovary(1)|lung(1)	4					Acitretin(DB00459)|Adapalene(DB00210)|Alitretinoin(DB00523)|Etretinate(DB00926)|Tazarotene(DB00799)|Tretinoin(DB00755)	TCCATCTCCAGGGGCAGGAGC	0.652		NaN									OREG0021862	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.09319	0	13	29									
LTA4H	4048	broad.mit.edu	37	12	96394858	96394858	+	Missense_Mutation	SNP	T	T	C			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr12:96394858T>C	uc001ten.1	-	19	1813	c.1745A>G	c.(1744-1746)CAT>CGT	p.H582R	LTA4H_uc010suy.1_Missense_Mutation_p.H544R|LTA4H_uc010suz.1_3'UTR	NM_000895	NP_000886	P09960	LKHA4_HUMAN	leukotriene A4 hydrolase	582					hormone biosynthetic process|inflammatory response|leukotriene biosynthetic process|peptide catabolic process|prostanoid metabolic process|proteolysis	cytosol|nucleus	aminopeptidase activity|epoxide hydrolase activity|leukotriene-A4 hydrolase activity|metallopeptidase activity|protein binding|zinc ion binding			haematopoietic_and_lymphoid_tissue(1)	1						AGCTTGATCATGGGATTTGTC	0.363		NaN											0	0	0	0.058154	0	9	50									
B3GNT4	79369	broad.mit.edu	37	12	122689184	122689184	+	Missense_Mutation	SNP	T	T	G			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr12:122689184T>G	uc001ubx.2	+	2	237	c.19T>G	c.(19-21)TCC>GCC	p.S7A	B3GNT4_uc001uby.2_Intron	NM_030765	NP_110392	Q9C0J1	B3GN4_HUMAN	UDP-GlcNAc:betaGal	7	Cytoplasmic (Potential).				protein glycosylation	Golgi membrane|integral to membrane	galactosyltransferase activity			ovary(1)	1	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000297)|Epithelial(86;0.000497)|BRCA - Breast invasive adenocarcinoma(302;0.222)		TCCCCAGCCTTCCGCAGCCCA	0.537		NaN											0	0	0	0.038147	0	7	26									
GPR133	283383	broad.mit.edu	37	12	131476886	131476886	+	Silent	SNP	C	C	T			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr12:131476886C>T	uc001uit.3	+	8	1474	c.915C>T	c.(913-915)CTC>CTT	p.L305L	GPR133_uc010tbm.1_Silent_p.L337L	NM_198827	NP_942122	Q6QNK2	GP133_HUMAN	G protein-coupled receptor 133 precursor	305	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			pancreas(5)|ovary(3)|skin(2)	10	all_neural(191;0.0982)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.68e-06)|all cancers(50;2.71e-06)|Epithelial(86;6.75e-06)		ATGTATCCCTCAGCTTACCCA	0.502		NaN											0	0	0	0.116897	0	30	86									
MIPEP	4285	broad.mit.edu	37	13	24304530	24304530	+	Missense_Mutation	SNP	T	T	C			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr13:24304530T>C	uc001uox.3	-	19	2199	c.2099A>G	c.(2098-2100)GAC>GGC	p.D700G		NM_005932	NP_005923	Q99797	MIPEP_HUMAN	mitochondrial intermediate peptidase precursor	700					protein processing involved in protein targeting to mitochondrion|proteolysis	mitochondrial matrix	metal ion binding|metalloendopeptidase activity			central_nervous_system(1)	1		all_cancers(29;1.83e-22)|all_epithelial(30;8.75e-19)|all_lung(29;9.17e-18)|Lung SC(185;0.0225)|Breast(139;0.14)		all cancers(112;0.00389)|Epithelial(112;0.0266)|OV - Ovarian serous cystadenocarcinoma(117;0.0717)|Lung(94;0.207)|GBM - Glioblastoma multiforme(144;0.232)		CAGATCCAAGTCGGAAACGAG	0.413		NaN											0	0	0	0.219247	0	21	11									
BRCA2	675	broad.mit.edu	37	13	32900694	32900694	+	Missense_Mutation	SNP	T	T	C	rs80358805		TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr13:32900694T>C	uc001uub.1	+	7	802	c.575T>C	c.(574-576)ATG>ACG	p.M192T	BRCA2_uc001uua.1_Missense_Mutation_p.M69T	NM_000059	NP_000050	P51587	BRCA2_HUMAN	breast cancer 2, early onset	192			M -> T (in one patient with pancreatic cancer).		cell cycle cytokinesis|centrosome duplication|double-strand break repair via homologous recombination|negative regulation of mammary gland epithelial cell proliferation|nucleotide-excision repair|positive regulation of transcription, DNA-dependent|regulation of S phase of mitotic cell cycle	BRCA2-MAGE-D1 complex|centrosome|nucleoplasm|stored secretory granule	gamma-tubulin binding|H3 histone acetyltransferase activity|H4 histone acetyltransferase activity|protease binding|single-stranded DNA binding			ovary(20)|endometrium(8)|lung(7)|breast(7)|oesophagus(5)|large_intestine(4)|central_nervous_system(3)|pancreas(3)|skin(2)|upper_aerodigestive_tract(1)|cervix(1)|salivary_gland(1)|liver(1)|kidney(1)	64		Lung SC(185;0.0262)		all cancers(112;7.13e-07)|Epithelial(112;1.59e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.000732)|BRCA - Breast invasive adenocarcinoma(63;0.0291)|GBM - Glioblastoma multiforme(144;0.0704)		GATCCTGATATGTCTTGGTCA	0.393		NaN	D|Mis|N|F|S		breast|ovarian|pancreatic	breast|ovarian|pancreatic|leukemia  (FANCB|FANCD1)		Direct_reversal_of_damage|Homologous_recombination	Fanconi_Anemia_type_D1_bi-allelic_BRCA2_mutations|Fanconi_Anemia|Pancreatic_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_BRCA2_type|Hereditary_Prostate_Cancer|Li-Fraumeni_syndrome	TCGA Ovarian(8;0.087)			0	0	0	0.139131	0	45	37									
LPAR6	10161	broad.mit.edu	37	13	48985612	48985612	+	Silent	SNP	G	G	A			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr13:48985612G>A	uc010acu.2	-	1	2042	c.948C>T	c.(946-948)TTC>TTT	p.F316F	RB1_uc001vcb.2_Intron|LPAR6_uc001vcc.1_Intron|LPAR6_uc001vce.2_Silent_p.F316F|LPAR6_uc001vcf.2_Silent_p.F316F	NM_001162498	NP_001155970	P43657	LPAR6_HUMAN	G-protein coupled purinergic receptor P2Y5	316	Cytoplasmic (Potential).					integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled	p.?(4)		ovary(4)	4						GAACTTCAGAGAATCTGAAGT	0.338		NaN											0	0	0	0.26419	0	24	87									
MLNR	2862	broad.mit.edu	37	13	49795318	49795318	+	Missense_Mutation	SNP	G	G	A			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr13:49795318G>A	uc010tgj.1	+	1	845	c.845G>A	c.(844-846)CGA>CAA	p.R282Q		NM_001507	NP_001498	O43193	MTLR_HUMAN	motilin receptor	282	Cytoplasmic (Potential).				digestion	integral to plasma membrane	growth hormone-releasing hormone receptor activity				0		all_lung(13;8.31e-06)|Lung NSC(96;0.000251)|Breast(56;0.0008)|Prostate(109;0.00446)|Hepatocellular(98;0.0556)|Glioma(44;0.236)	KIRC - Kidney renal clear cell carcinoma(9;0.206)	GBM - Glioblastoma multiforme(99;6.1e-09)		CGGCCGCTGCGAGGCCCGGCC	0.701		NaN											0	0	0	0.204396	0	20	4									
MYCBP2	23077	broad.mit.edu	37	13	77750673	77750673	+	Missense_Mutation	SNP	C	C	T			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr13:77750673C>T	uc001vkf.2	-	37	5408	c.5317G>A	c.(5317-5319)GAT>AAT	p.D1773N	MYCBP2_uc010aev.2_Missense_Mutation_p.D1177N	NM_015057	NP_055872	O75592	MYCB2_HUMAN	MYC binding protein 2	1773					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ligase activity|protein binding|zinc ion binding			ovary(4)|breast(4)|skin(3)|lung(2)|pancreas(1)	14		Breast(118;0.212)|Acute lymphoblastic leukemia(28;0.22)		GBM - Glioblastoma multiforme(99;0.109)		TCAGCTATATCACTGGGTGAG	0.363		NaN											0	0	0	0.248553	0	6	24									
FAM70B	348013	broad.mit.edu	37	13	114514838	114514838	+	Missense_Mutation	SNP	T	T	C			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr13:114514838T>C	uc001vuh.2	+	9	970	c.943T>C	c.(943-945)TTT>CTT	p.F315L		NM_182614	NP_872420	Q8WV15	FA70B_HUMAN	family with sequence similarity 70, member B	315	Pro-rich.					integral to membrane					0	Lung NSC(43;0.00976)|all_neural(89;0.0337)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_lung(25;0.123)|all_epithelial(44;0.133)	all cancers(43;0.181)			ACCCACCTACTTTCCCCCGGG	0.567		NaN											0	0	0	0.204396	0	18	75									
TC2N	123036	broad.mit.edu	37	14	92278710	92278710	+	Missense_Mutation	SNP	A	A	G			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr14:92278710A>G	uc001xzu.3	-	3	438	c.247T>C	c.(247-249)TCT>CCT	p.S83P	TC2N_uc001xzt.3_Missense_Mutation_p.S83P|TC2N_uc010auc.2_Missense_Mutation_p.S83P|TC2N_uc001xzv.3_Missense_Mutation_p.S83P	NM_001128595	NP_001122067	Q8N9U0	TAC2N_HUMAN	tandem C2 domains, nuclear	83						nucleus				upper_aerodigestive_tract(1)	1				COAD - Colon adenocarcinoma(157;0.218)		TGAATGTAAGATAACTTAAAC	0.363		NaN											0	0	0	0.11911	0	14	19									
CDC42BPB	9578	broad.mit.edu	37	14	103440459	103440459	+	Missense_Mutation	SNP	T	T	G			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr14:103440459T>G	uc001ymi.1	-	12	1767	c.1535A>C	c.(1534-1536)GAG>GCG	p.E512A		NM_006035	NP_006026	Q9Y5S2	MRCKB_HUMAN	CDC42-binding protein kinase beta	512	Potential.				actin cytoskeleton reorganization|establishment or maintenance of cell polarity|intracellular signal transduction	cell leading edge|cell-cell junction|cytoplasm|cytoskeleton	ATP binding|magnesium ion binding|protein serine/threonine kinase activity|small GTPase regulator activity			large_intestine(3)|skin(3)|lung(2)|stomach(1)|breast(1)|ovary(1)	11		Melanoma(154;0.155)		Colorectal(3;0.0129)|READ - Rectum adenocarcinoma(2;0.0419)|Epithelial(152;0.0474)|all cancers(159;0.199)		CACTGTGTCCTCAAGCTGTCG	0.532		NaN											0	0	0	0.09319	0	12	36									
TDRD9	122402	broad.mit.edu	37	14	104471727	104471727	+	Silent	SNP	C	C	T			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr14:104471727C>T	uc001yom.3	+	15	1728	c.1698C>T	c.(1696-1698)ATC>ATT	p.I566I	TDRD9_uc001yon.3_Silent_p.I304I	NM_153046	NP_694591	Q8NDG6	TDRD9_HUMAN	tudor domain containing 9	566					cell differentiation|DNA methylation involved in gamete generation|fertilization|gene silencing by RNA|male meiosis|multicellular organismal development|piRNA metabolic process|spermatogenesis	nucleus|piP-body	ATP binding|ATP-dependent helicase activity|nucleic acid binding			ovary(2)|central_nervous_system(1)	3		all_cancers(154;0.109)|Melanoma(154;0.0525)|all_epithelial(191;0.0768)				AGCGCACCATCCTTCTACTAA	0.532		NaN											0	0	0	0.105934	0	14	26									
MESDC2	23184	broad.mit.edu	37	15	81282111	81282111	+	Missense_Mutation	SNP	G	G	A			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr15:81282111G>A	uc002bfy.1	-	1	95	c.22C>T	c.(22-24)CGC>TGC	p.R8C	MESDC2_uc002bfx.2_RNA|MESDC2_uc010uno.1_RNA	NM_015154	NP_055969	Q14696	MESD_HUMAN	mesoderm development candidate 2	8	Chaperone domain (By similarity).				mesoderm development|protein folding|Wnt receptor signaling pathway	endoplasmic reticulum					0						ACGGCCTTGCGCGCCCACCTG	0.647		NaN											0	0	0	0.09319	0	13	3									
KIAA0430	9665	broad.mit.edu	37	16	15705592	15705592	+	Splice_Site	SNP	C	C	T			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr16:15705592C>T	uc002ddr.2	-	18	3668	c.3475_splice	c.e18-1	p.I1159_splice	KIAA0430_uc002ddq.2_Splice_Site_p.I993_splice|KIAA0430_uc010uzv.1_Splice_Site_p.I1155_splice|KIAA0430_uc010uzw.1_Splice_Site_p.I1158_splice	NM_014647	NP_055462	Q9Y4F3	LKAP_HUMAN	limkain b1							peroxisome	nucleotide binding|RNA binding				0						TTCCAAGAATCTGCAAAGCAA	0.488		NaN											0	0	0	0.26419	0	24	26									
SCNN1G	6340	broad.mit.edu	37	16	23224042	23224042	+	Missense_Mutation	SNP	G	G	T			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr16:23224042G>T	uc002dlm.1	+	9	1477	c.1338G>T	c.(1336-1338)GAG>GAT	p.E446D		NM_001039	NP_001030	P51170	SCNNG_HUMAN	sodium channel, nonvoltage-gated 1, gamma	446	Extracellular (By similarity).				excretion|sensory perception of taste	apical plasma membrane|integral to plasma membrane	ligand-gated sodium channel activity|WW domain binding			ovary(2)|skin(2)|large_intestine(1)|pancreas(1)	6				GBM - Glioblastoma multiforme(48;0.0366)	Amiloride(DB00594)|Triamterene(DB00384)	TCCAGGAAGAGCTGGGCTGCC	0.587		NaN											1	0	4.96729e-08	0.204396	5.25024e-08	18	71									
ERN2	10595	broad.mit.edu	37	16	23718361	23718361	+	Missense_Mutation	SNP	G	G	T			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr16:23718361G>T	uc002dma.3	-	5	659	c.490C>A	c.(490-492)CCC>ACC	p.P164T	ERN2_uc010bxp.2_Missense_Mutation_p.P164T|ERN2_uc010bxq.1_5'UTR	NM_033266	NP_150296	Q76MJ5	ERN2_HUMAN	endoplasmic reticulum to nucleus signalling 2	116	Lumenal (Potential).				apoptosis|induction of apoptosis|mRNA processing|negative regulation of transcription, DNA-dependent|rRNA catabolic process|transcription, DNA-dependent	endoplasmic reticulum membrane|integral to membrane	ATP binding|endoribonuclease activity, producing 5'-phosphomonoesters|magnesium ion binding|protein serine/threonine kinase activity			large_intestine(2)|lung(2)|ovary(2)	6				GBM - Glioblastoma multiforme(48;0.0156)		CTGCGGCAGGGAGAGGCATGA	0.552		NaN											1	0	1.05317e-09	0.11911	1.14207e-09	13	27									
TMEM208	29100	broad.mit.edu	37	16	67262275	67262275	+	Silent	SNP	G	G	A			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr16:67262275G>A	uc002esi.2	+	3	226	c.120G>A	c.(118-120)GTG>GTA	p.V40V	LRRC29_uc002ese.2_5'Flank|LRRC29_uc002esf.2_5'Flank|LRRC29_uc002esg.2_5'Flank|LRRC29_uc010vjg.1_5'Flank|TMEM208_uc002esj.2_RNA	NM_014187	NP_054906	Q9BTX3	TM208_HUMAN	HSPC171 protein	40	Helical; (Potential).					integral to membrane					0		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.00067)|Epithelial(162;0.00442)|all cancers(182;0.0417)		ACTGCCTTGTGACGTTGGTCT	0.512		NaN											0	0	0	0.219247	0	20	54									
ZZEF1	23140	broad.mit.edu	37	17	3936218	3936218	+	Silent	SNP	G	G	A			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr17:3936218G>A	uc002fxe.2	-	41	6727	c.6663C>T	c.(6661-6663)GTC>GTT	p.V2221V	ZZEF1_uc002fxh.2_Silent_p.V535V|ZZEF1_uc002fxi.2_Silent_p.V456V	NM_015113	NP_055928	O43149	ZZEF1_HUMAN	zinc finger, ZZ type with EF hand domain 1	2221							calcium ion binding|zinc ion binding			ovary(2)|central_nervous_system(1)|pancreas(1)	4						AGGTGGCAATGACATCACGCC	0.587		NaN											0	0	0	0.248553	0	7	14									
ENO3	2027	broad.mit.edu	37	17	4859385	4859385	+	Missense_Mutation	SNP	C	C	A			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr17:4859385C>A	uc002gab.3	+	9	1108	c.1014C>A	c.(1012-1014)AAC>AAA	p.N338K	ENO3_uc002gac.3_Missense_Mutation_p.N338K|ENO3_uc010vss.1_Missense_Mutation_p.N295K|ENO3_uc010vst.1_Missense_Mutation_p.N165K	NM_053013	NP_443739	P13929	ENOB_HUMAN	enolase 3	338					gluconeogenesis|glycolysis	phosphopyruvate hydratase complex	magnesium ion binding|phosphopyruvate hydratase activity			ovary(1)	1						AGGCCTGCAACTGTCTGCTGC	0.597		NaN											1	0	2.4624e-09	0.204396	2.63603e-09	21	54									
DNAH2	146754	broad.mit.edu	37	17	7734577	7734577	+	Missense_Mutation	SNP	C	C	T			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr17:7734577C>T	uc002giu.1	+	79	12418	c.12404C>T	c.(12403-12405)TCC>TTC	p.S4135F	DNAH2_uc010cnm.1_Missense_Mutation_p.S1073F	NM_020877	NP_065928	Q9P225	DYH2_HUMAN	dynein heavy chain domain 3	4135	TPR 5.				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(6)|skin(6)|central_nervous_system(1)	13		all_cancers(10;4.66e-07)|Prostate(122;0.081)				ACTTTGCTTTCCTTGCAACCT	0.572		NaN											0	0	0	0.144211	0	32	158									
MYH10	4628	broad.mit.edu	37	17	8417200	8417200	+	Silent	SNP	C	C	T			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr17:8417200C>T	uc002gll.2	-	20	2520	c.2424G>A	c.(2422-2424)AAG>AAA	p.K808K	MYH10_uc002glm.2_Silent_p.K839K|MYH10_uc010cnx.2_Silent_p.K817K	NM_005964	NP_005955	P35580	MYH10_HUMAN	myosin, heavy polypeptide 10, non-muscle	808	IQ.				actin filament-based movement|axon guidance|cytokinesis after mitosis|regulation of cell shape	cell cortex|cleavage furrow|midbody|myosin complex|stress fiber	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(2)	2						GCTGCTGCTTCTTGGCAAAGG	0.458		NaN											0	0	0	0.219247	0	22	16									
MYH8	4626	broad.mit.edu	37	17	10298707	10298707	+	Missense_Mutation	SNP	T	T	A			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr17:10298707T>A	uc002gmm.2	-	34	4800	c.4705A>T	c.(4705-4707)AAC>TAC	p.N1569Y	uc002gml.1_Intron	NM_002472	NP_002463	P13535	MYH8_HUMAN	myosin, heavy chain 8, skeletal muscle,	1569	Potential.				muscle filament sliding	cytosol|muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			skin(6)|ovary(3)|breast(2)	11						TTGACTTGGTTTAACTCAAGC	0.393		NaN							Trismus-Pseudocamptodactyly_Syndrome_with_Cardiac_Myxoma_and_Freckling				0	0	0	0.234183	0	21	64									
ITGA2B	3674	broad.mit.edu	37	17	42462976	42462976	+	Missense_Mutation	SNP	C	C	T			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr17:42462976C>T	uc002igt.1	-	4	549	c.517G>A	c.(517-519)GAG>AAG	p.E173K		NM_000419	NP_000410	P08514	ITA2B_HUMAN	integrin alpha 2b preproprotein	173	Extracellular (Potential).|FG-GAP 2.				axon guidance|integrin-mediated signaling pathway|platelet activation|platelet degranulation	integrin complex|platelet alpha granule membrane	identical protein binding|receptor activity			ovary(2)|lung(1)	3		Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.191)	Tirofiban(DB00775)	GGGGAGTACTCGGCGCGGCGG	0.617		NaN											0	0	0	0.217242	0	5	5									
DDX5	1655	broad.mit.edu	37	17	62496243	62496243	+	Missense_Mutation	SNP	T	T	C			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr17:62496243T>C	uc002jek.2	-	13	1890	c.1643A>G	c.(1642-1644)AAT>AGT	p.N548S	DDX5_uc010deh.2_Missense_Mutation_p.N548S|DDX5_uc002jej.2_Missense_Mutation_p.N443S|DDX5_uc010wqa.1_Missense_Mutation_p.N469S	NM_004396	NP_004387	P17844	DDX5_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 5	548					cell growth|regulation of alternative nuclear mRNA splicing, via spliceosome	catalytic step 2 spliceosome|nucleolus	ATP binding|ATP-dependent helicase activity|mRNA binding|protein binding|RNA helicase activity|transcription cofactor activity			ovary(2)|lung(1)	3	Breast(5;2.15e-14)		BRCA - Breast invasive adenocarcinoma(8;8.6e-12)			AGACACAAAATTACTTCCAAA	0.413		NaN	T	ETV4	prostate								0	0	0	0.139131	0	59	60									
RAB37	326624	broad.mit.edu	37	17	72741012	72741012	+	Missense_Mutation	SNP	G	G	T			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr17:72741012G>T	uc002jlk.2	+	7	489	c.433G>T	c.(433-435)GCG>TCG	p.A145S	RAB37_uc002jlc.2_3'UTR|RAB37_uc010dfu.2_Missense_Mutation_p.A138S|RAB37_uc002jld.2_Missense_Mutation_p.A138S|RAB37_uc010wrb.1_Missense_Mutation_p.A113S|RAB37_uc010wrc.1_Missense_Mutation_p.A150S|RAB37_uc010wrd.1_Missense_Mutation_p.A113S|RAB37_uc010wre.1_Missense_Mutation_p.A108S|RAB37_uc002jll.3_RNA	NM_001006638	NP_001006639	Q96AX2	RAB37_HUMAN	RAB37, member RAS oncogene family isoform 2	145	GTP (By similarity).				protein transport|small GTPase mediated signal transduction	ER-Golgi intermediate compartment	GTP binding			ovary(1)	1						GGCTTGACAGGCGGATATGAG	0.617		NaN									OREG0024716	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	1	0	8.28177e-16	0.189662	9.22037e-16	20	32									
DSC1	1823	broad.mit.edu	37	18	28737511	28737511	+	Silent	SNP	C	C	G	rs147816863		TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr18:28737511C>G	uc002kwn.2	-	3	436	c.174G>C	c.(172-174)TCG>TCC	p.S58S	DSC1_uc002kwm.2_Silent_p.S58S	NM_024421	NP_077739	Q08554	DSC1_HUMAN	desmocollin 1 isoform Dsc1a preproprotein	58					homophilic cell adhesion	desmosome|gap junction|integral to membrane|membrane fraction	calcium ion binding			ovary(3)|skin(1)	4			OV - Ovarian serous cystadenocarcinoma(10;0.00778)			TTAGGCTGGCCGACTTGAGAC	0.448		NaN											0	0	0	0.11911	0	14	43									
LINGO3	645191	broad.mit.edu	37	19	2290209	2290209	+	Missense_Mutation	SNP	C	C	T			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr19:2290209C>T	uc010dsx.1	-	2	1695	c.1567G>A	c.(1567-1569)GAC>AAC	p.D523N	SPPL2B_uc010dsw.1_Intron|uc002lvo.1_5'UTR	NM_001101391	NP_001094861	P0C6S8	LIGO3_HUMAN	leucine rich repeat and Ig domain containing 3	523	Extracellular (Potential).					integral to membrane					0						GTGGTGAGGTCGAGCGGCGCG	0.716		NaN											0	0	0	0.11911	0	14	11									
KHSRP	8570	broad.mit.edu	37	19	6418059	6418059	+	Missense_Mutation	SNP	C	C	T			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr19:6418059C>T	uc002mer.3	-	10	1021	c.911G>A	c.(910-912)CGG>CAG	p.R304Q		NM_003685	NP_003676	Q92945	FUBP2_HUMAN	KH-type splicing regulatory protein	304	Gly-rich.				mRNA processing|mRNA transport|regulation of transcription, DNA-dependent|RNA splicing, via transesterification reactions|transcription, DNA-dependent	cytosol|nucleus	DNA binding|protein binding|RNA binding			skin(1)	1						GTCACGTTCCCGGAGGATGTC	0.642		NaN									OREG0025200	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.184627	0	5	21									
COL5A3	50509	broad.mit.edu	37	19	10099815	10099815	+	Silent	SNP	T	T	C			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr19:10099815T>C	uc002mmq.1	-	27	2216	c.2130A>G	c.(2128-2130)GGA>GGG	p.G710G		NM_015719	NP_056534	P25940	CO5A3_HUMAN	collagen, type V, alpha 3 preproprotein	710	Triple-helical region.				collagen fibril organization|skin development	collagen type V	collagen binding|extracellular matrix structural constituent			ovary(7)|lung(1)|central_nervous_system(1)|skin(1)	10			Epithelial(33;7.11e-05)			CTCCCCGAGGTCCAGGATAGC	0.542		NaN											0	0	0	0.125774	0	28	50									
TSPAN16	26526	broad.mit.edu	37	19	11417292	11417292	+	Missense_Mutation	SNP	G	G	T			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr19:11417292G>T	uc002mqv.1	+	5	613	c.463G>T	c.(463-465)GGG>TGG	p.G155W	TSPAN16_uc002mqu.1_RNA|uc002mqw.1_Intron	NM_012466	NP_036598	Q9UKR8	TSN16_HUMAN	transmembrane 4 superfamily member 16	155	Cytoplasmic (Potential).					integral to membrane				skin(1)	1						AAAGTGCTGTGGGGTGAATAA	0.438		NaN											1	0	9.04412e-07	0.099896	9.4398e-07	25	40									
NDUFA13	51079	broad.mit.edu	37	19	19646428	19646428	+	Missense_Mutation	SNP	C	C	T			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr19:19646428C>T	uc010xqy.1	+	7	1139	c.880C>T	c.(880-882)CGC>TGC	p.R294C	YJEFN3_uc002nmt.1_Missense_Mutation_p.R212C|YJEFN3_uc010ecf.1_Missense_Mutation_p.R162C|YJEFN3_uc002nmu.1_RNA|CILP2_uc002nmv.3_5'Flank|CILP2_uc002nmw.3_5'Flank	NM_015965	NP_057049	Q9P0J0	NDUAD_HUMAN	NADH dehydrogenase (ubiquinone) 1 alpha	Error:Variant_position_missing_in_Q9P0J0_after_alignment					apoptotic nuclear change|induction of apoptosis by extracellular signals|negative regulation of cell growth|negative regulation of transcription, DNA-dependent|negative regulation of translation|protein import into nucleus|reactive oxygen species metabolic process|respiratory electron transport chain	integral to membrane|mitochondrial respiratory chain complex I|nucleoplasm	ATP binding|NADH dehydrogenase (ubiquinone) activity|protein binding				0					NADH(DB00157)	CCCCTGCACCCGCGCGCTGGC	0.706		NaN											0	0	0	0.115264	0	3	9									
TSHZ3	57616	broad.mit.edu	37	19	31768141	31768141	+	Missense_Mutation	SNP	T	T	A			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr19:31768141T>A	uc002nsy.3	-	2	2623	c.2558A>T	c.(2557-2559)AAC>ATC	p.N853I		NM_020856	NP_065907	Q63HK5	TSH3_HUMAN	zinc finger protein 537	853					negative regulation of transcription, DNA-dependent|regulation of respiratory gaseous exchange by neurological system process	growth cone|nucleus	chromatin binding|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)|skin(2)|pancreas(1)|lung(1)	8	Esophageal squamous(110;0.226)					CTCTGTCAAGTTCTTCAGCAT	0.527		NaN											0	0	0	0.249174	0	22	91									
MLL4	9757	broad.mit.edu	37	19	36229445	36229445	+	Missense_Mutation	SNP	G	G	A			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;WGS			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr19:36229445G>A	uc010eei.2	+	38	8135	c.8135G>A	c.(8134-8136)CGG>CAG	p.R2712Q		NM_014727	NP_055542	Q9UMN6	MLL4_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 4	2712	Post-SET.				chromatin-mediated maintenance of transcription		DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(6)|breast(2)|ovary(1)|kidney(1)|skin(1)	11	all_lung(56;3.33e-07)|Lung NSC(56;5.02e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			CGCTGCCGTCGGTTCCTTAAC	0.652		NaN											0	0	0	0.248553	0	6	8									
DPF1	8193	broad.mit.edu	37	19	38709576	38709576	+	Missense_Mutation	SNP	A	A	G			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr19:38709576A>G	uc002ohl.2	-	4	529	c.502T>C	c.(502-504)TGT>CGT	p.C168R	DPF1_uc002ohm.2_Missense_Mutation_p.C168R|DPF1_uc002ohn.2_Missense_Mutation_p.C86R|DPF1_uc010xtu.1_Missense_Mutation_p.C142R|DPF1_uc010xtv.1_Missense_Mutation_p.C142R|DPF1_uc010xtw.1_Missense_Mutation_p.C142R	NM_004647	NP_004638	Q92782	DPF1_HUMAN	D4, zinc and double PHD fingers family 1 isoform	168					induction of apoptosis|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nBAF complex	zinc ion binding				0	all_cancers(60;1.24e-06)		Lung(45;0.000246)|LUSC - Lung squamous cell carcinoma(53;0.000292)			CCCACCTGACAGTCCATAATG	0.657		NaN											0	0	0	0.268233	0	44	61									
ERCC2	2068	broad.mit.edu	37	19	45872380	45872380	+	Missense_Mutation	SNP	G	G	A			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq;WGS			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr19:45872380G>A	uc002pbj.2	-	3	178	c.131C>T	c.(130-132)TCA>TTA	p.S44L	ERCC2_uc010ejz.2_Missense_Mutation_p.S44L|ERCC2_uc002pbk.2_Missense_Mutation_p.S20L|ERCC2_uc002pbl.3_Missense_Mutation_p.S20L|ERCC2_uc010xxj.1_RNA	NM_000400	NP_000391	P18074	ERCC2_HUMAN	excision repair cross-complementing rodent	44	ATP (By similarity).|Helicase ATP-binding.				cell cycle checkpoint|chromosome segregation|hair cell differentiation|induction of apoptosis|interspecies interaction between organisms|mRNA capping|nucleotide-excision repair, DNA damage removal|nucleotide-excision repair, DNA incision|positive regulation of transcription from RNA polymerase II promoter|positive regulation of viral transcription|protein phosphorylation|response to oxidative stress|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase I promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|UV protection|viral reproduction	cytoplasm|holo TFIIH complex|MMXD complex	5'-3' DNA helicase activity|ATP binding|ATP-dependent DNA helicase activity|DNA binding|iron-sulfur cluster binding|metal ion binding|protein C-terminus binding|protein N-terminus binding			lung(2)|pancreas(1)	3		Ovarian(192;0.0728)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.0226)		CCCGGTGCCTGAGGGCATCTC	0.587		NaN	Mis|N|F|S			skin basal cell|skin squamous cell|melanoma		Direct_reversal_of_damage|NER	Xeroderma_Pigmentosum				0	0	0	0.204396	0	18	77									
GRLF1	2909	broad.mit.edu	37	19	47422438	47422438	+	Missense_Mutation	SNP	G	G	A			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr19:47422438G>A	uc010ekv.2	+	1	506	c.506G>A	c.(505-507)GGC>GAC	p.G169D		NM_004491	NP_004482	Q9NRY4	RHG35_HUMAN	glucocorticoid receptor DNA binding factor 1	169					axon guidance|negative regulation of transcription, DNA-dependent|small GTPase mediated signal transduction|transcription, DNA-dependent	cytosol	DNA binding|Rho GTPase activator activity|transcription corepressor activity			central_nervous_system(1)	1		all_cancers(25;1.51e-09)|all_epithelial(76;1.87e-07)|all_lung(116;7.86e-06)|Lung NSC(112;2.31e-05)|Ovarian(192;0.0129)|all_neural(266;0.026)|Breast(70;0.077)		all cancers(93;2.03e-05)|OV - Ovarian serous cystadenocarcinoma(262;2.57e-05)|Epithelial(262;0.00135)|GBM - Glioblastoma multiforme(486;0.0289)		GTTAGCAGGGGCATGAATAGG	0.458		NaN											0	0	0	0.125774	0	30	37									
ZNF671	79891	broad.mit.edu	37	19	58232719	58232719	+	Silent	SNP	T	T	C			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr19:58232719T>C	uc002qpz.3	-	4	834	c.735A>G	c.(733-735)AAA>AAG	p.K245K	ZNF776_uc002qpx.2_Intron|ZNF671_uc010eug.2_Silent_p.K168K|ZNF671_uc010yhf.1_Silent_p.K147K	NM_024833	NP_079109	Q8TAW3	ZN671_HUMAN	zinc finger protein 671	245					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Colorectal(82;0.000256)|all_neural(62;0.0577)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0257)		CTCTCCTACCTTTCCCACATG	0.527		NaN											0	0	0	0.132662	0	16	44									
ALLC	55821	broad.mit.edu	37	2	3750104	3750104	+	Missense_Mutation	SNP	G	G	A			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr2:3750104G>A	uc010ewt.2	+	12	1288	c.1127G>A	c.(1126-1128)CGG>CAG	p.R376Q	ALLC_uc002qyf.2_Missense_Mutation_p.R147Q	NM_018436	NP_060906	Q8N6M5	ALLC_HUMAN	allantoicase isoform a	395							allantoicase activity			central_nervous_system(1)	1	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.088)	all_cancers(51;0.24)		OV - Ovarian serous cystadenocarcinoma(76;0.088)|all cancers(51;0.151)|Epithelial(75;0.206)		CTGAGGCCCCGGGAGAAGCCC	0.597		NaN								HNSCC(21;0.051)			0	0	0	0.09319	0	12	27									
C2orf39	92749	broad.mit.edu	37	2	26624885	26624885	+	Silent	SNP	C	C	T			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr2:26624885C>T	uc002rhg.2	+	1	102	c.28C>T	c.(28-30)CTG>TTG	p.L10L	C2orf39_uc010eym.1_RNA	NM_145038	NP_659475	Q96MC2	CC164_HUMAN	hypothetical protein LOC92749	10											0	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CCTAGAGGCCCTGGACCCGAA	0.657		NaN											0	0	0	0.038147	0	7	19									
VIT	5212	broad.mit.edu	37	2	37032673	37032673	+	Missense_Mutation	SNP	G	G	T			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr2:37032673G>T	uc002rpl.2	+	14	1476	c.1255G>T	c.(1255-1257)GGC>TGC	p.G419C	VIT_uc002rpm.2_Missense_Mutation_p.G397C|VIT_uc010ezv.2_Missense_Mutation_p.G375C|VIT_uc010ezw.2_Missense_Mutation_p.G376C	NM_053276	NP_444506	Q6UXI7	VITRN_HUMAN	vitrin	404	VWFA 1.					proteinaceous extracellular matrix				ovary(1)|pancreas(1)	2		all_hematologic(82;0.248)				GATGGTGGATGGCTGGCCCAC	0.502		NaN											1	0	2.39556e-15	0.26419	2.6494e-15	23	106									
MPHOSPH10	10199	broad.mit.edu	37	2	71368431	71368431	+	Missense_Mutation	SNP	T	T	A			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr2:71368431T>A	uc002sht.1	+	7	1730	c.1378T>A	c.(1378-1380)TTA>ATA	p.L460I		NM_005791	NP_005782	O00566	MPP10_HUMAN	M-phase phosphoprotein 10	460					RNA splicing, via transesterification reactions|rRNA processing	chromosome|nucleolus|small nucleolar ribonucleoprotein complex	protein binding			skin(2)|ovary(1)	3						GCGTTTAACCTTAGACCATGA	0.378		NaN											0	0	0	0.139131	0	89	180									
FAHD2A	51011	broad.mit.edu	37	2	96072867	96072867	+	Missense_Mutation	SNP	G	G	C			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr2:96072867G>C	uc002sur.2	+	3	603	c.424G>C	c.(424-426)GGG>CGG	p.G142R	FAHD2A_uc002sus.2_Missense_Mutation_p.G142R	NM_016044	NP_057128	Q96GK7	FAH2A_HUMAN	fumarylacetoacetate hydrolase domain containing	142							hydrolase activity|metal ion binding			ovary(1)	1						CTCCATCGTGGGGCCCTATGA	0.577		NaN											0	0	0	0.153744	0	32	45									
GLI2	2736	broad.mit.edu	37	2	121747297	121747297	+	Silent	SNP	C	C	T			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr2:121747297C>T	uc010flp.2	+	13	3837	c.3807C>T	c.(3805-3807)TCC>TCT	p.S1269S	GLI2_uc002tmq.1_Intron|GLI2_uc002tmr.1_Intron|GLI2_uc002tmt.3_Silent_p.S941S|GLI2_uc002tmu.3_Silent_p.S924S	NM_005270	NP_005261	P10070	GLI2_HUMAN	GLI-Kruppel family member GLI2	1269					axon guidance|branching morphogenesis of a tube|cell proliferation|cerebellar cortex morphogenesis|developmental growth|embryonic digestive tract development|epidermal cell differentiation|floor plate formation|heart development|hindgut morphogenesis|kidney development|lung development|negative regulation of transcription from RNA polymerase II promoter|odontogenesis of dentine-containing tooth|osteoblast development|osteoblast differentiation|pituitary gland development|positive regulation of DNA replication|positive regulation of T cell differentiation in thymus|positive regulation of transcription from RNA polymerase II promoter|proximal/distal pattern formation|skeletal system development|smoothened signaling pathway involved in ventral spinal cord interneuron specification|spinal cord ventral commissure morphogenesis	nucleus|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|lung(2)|breast(1)|central_nervous_system(1)|pancreas(1)	13	Renal(3;0.0496)	Prostate(154;0.0623)				TCCCCCAATCCTGCAGCAACA	0.622		NaN											0	0	0	0.083992	0	24	15									
CCDC74B	91409	broad.mit.edu	37	2	130897506	130897506	+	Missense_Mutation	SNP	G	G	A			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr2:130897506G>A	uc002tqm.1	-	7	1027	c.965C>T	c.(964-966)ACG>ATG	p.T322M	CCDC74B_uc010yzw.1_Missense_Mutation_p.T424M|CCDC74B_uc002tqn.1_Missense_Mutation_p.T256M	NM_207310	NP_997193	Q96LY2	CC74B_HUMAN	coiled-coil domain containing 74B	322											0	Colorectal(110;0.1)					GGGGAAATGCGTGGCTTCTTG	0.627		NaN											0	0	0	0.249174	0	20	42									
RBM44	375316	broad.mit.edu	37	2	238726589	238726589	+	Missense_Mutation	SNP	G	G	A			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr2:238726589G>A	uc002vxi.3	+	3	1162	c.1030G>A	c.(1030-1032)GGA>AGA	p.G344R		NM_001080504	NP_001073973	Q6ZP01	RBM44_HUMAN	RNA binding motif protein 44	343							nucleotide binding|RNA binding			ovary(4)	4		Breast(86;0.0042)|Renal(207;0.00571)|Ovarian(221;0.17)|all_hematologic(139;0.182)		Epithelial(121;3.74e-22)|OV - Ovarian serous cystadenocarcinoma(60;5.3e-11)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;6.5e-08)|BRCA - Breast invasive adenocarcinoma(100;0.000118)|Lung(119;0.0112)|LUSC - Lung squamous cell carcinoma(224;0.0266)		AGATTTTTGTGGAAATAAAAT	0.308		NaN											0	0	0	0.116897	0	28	20									
CHGB	1114	broad.mit.edu	37	20	5904525	5904525	+	Missense_Mutation	SNP	G	G	T			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr20:5904525G>T	uc002wmg.2	+	4	2041	c.1735G>T	c.(1735-1737)GAT>TAT	p.D579Y	CHGB_uc010zqz.1_Missense_Mutation_p.D262Y	NM_001819	NP_001810	P05060	SCG1_HUMAN	chromogranin B precursor	579						extracellular region	hormone activity			breast(3)|skin(2)|ovary(1)	6						CTTCTCTGAGGATGTGAACTG	0.502		NaN											1	0	4.14922e-12	0.146539	4.52888e-12	15	52									
SAMHD1	25939	broad.mit.edu	37	20	35579911	35579911	+	Missense_Mutation	SNP	C	C	T			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr20:35579911C>T	uc002xgh.1	-	1	266	c.136G>A	c.(136-138)GGT>AGT	p.G46S		NM_015474	NP_056289	Q9Y3Z3	SAMH1_HUMAN	SAM domain- and HD domain-containing protein 1	46	SAM.				defense response to virus|innate immune response|regulation of innate immune response	nucleus	metal ion binding|phosphoric diester hydrolase activity				0		Myeloproliferative disorder(115;0.00878)				TGCTCCGGACCCCATGTCTTG	0.652		NaN											0	0	0	0.153744	0	32	148									
PSMA7	5688	broad.mit.edu	37	20	60714933	60714933	+	Silent	SNP	G	G	A			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr20:60714933G>A	uc002ybx.1	-	3	367	c.252C>T	c.(250-252)ATC>ATT	p.I84I	PSMA7_uc002yby.1_RNA	NM_002792	NP_002783	O14818	PSA7_HUMAN	proteasome alpha 7 subunit	84					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|interspecies interaction between organisms|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	cytoplasm|nucleus|proteasome core complex, alpha-subunit complex	identical protein binding|threonine-type endopeptidase activity				0	Breast(26;3.97e-09)		BRCA - Breast invasive adenocarcinoma(19;1.28e-07)			GGGCCCTGTTGATGACTATCC	0.597		NaN											0	0	0	0.11911	0	15	21									
DIDO1	11083	broad.mit.edu	37	20	61527666	61527666	+	Missense_Mutation	SNP	A	A	T			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr20:61527666A>T	uc002ydr.1	-	8	2397	c.2133T>A	c.(2131-2133)TTT>TTA	p.F711L	DIDO1_uc002yds.1_Missense_Mutation_p.F711L|DIDO1_uc002ydt.1_Missense_Mutation_p.F711L|DIDO1_uc002ydu.1_Missense_Mutation_p.F711L	NM_033081	NP_149072	Q9BTC0	DIDO1_HUMAN	death inducer-obliterator 1 isoform c	711	TFIIS central.				apoptosis|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			ovary(3)|skin(3)	6	Breast(26;5.68e-08)					GAAACAAGTTAAACATCTCCT	0.388		NaN											0	0	0	0.234183	0	23	56									
BRWD1	54014	broad.mit.edu	37	21	40569194	40569194	+	Missense_Mutation	SNP	G	G	A	rs145664878		TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr21:40569194G>A	uc002yxk.1	-	41	5940	c.5801C>T	c.(5800-5802)ACG>ATG	p.T1934M	BRWD1_uc010goc.1_Missense_Mutation_p.T577M|BRWD1_uc002yxl.2_Missense_Mutation_p.T1934M	NM_018963	NP_061836	Q9NSI6	BRWD1_HUMAN	bromodomain and WD repeat domain containing 1	1934					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus				skin(3)|ovary(1)	4		Prostate(19;8.44e-08)|all_epithelial(19;0.223)				ATTGGCAGCCGTAGCTGCACA	0.423		NaN											0	0	0	0.139131	0	56	29									
CHEK2	11200	broad.mit.edu	37	22	29091841	29091841	+	Silent	SNP	G	G	A	rs146546850	byFrequency	TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr22:29091841G>A	uc003adu.1	-	11	1188	c.1116C>T	c.(1114-1116)TCC>TCT	p.S372S	CHEK2_uc003ads.1_Silent_p.S151S|CHEK2_uc010gvh.1_Silent_p.S281S|CHEK2_uc010gvi.1_Intron|CHEK2_uc010gvj.1_Intron|CHEK2_uc003adr.1_RNA|CHEK2_uc010gvk.1_RNA|CHEK2_uc003adt.1_Silent_p.S415S|CHEK2_uc003adv.1_Silent_p.S343S|CHEK2_uc003adw.1_Silent_p.S372S|CHEK2_uc003adx.1_Silent_p.S151S|CHEK2_uc003ady.1_Silent_p.S372S|CHEK2_uc003adz.1_Silent_p.S176S	NM_007194	NP_009125	O96017	CHK2_HUMAN	protein kinase CHK2 isoform a	372	Protein kinase.				cell cycle|DNA damage checkpoint|DNA damage response, signal transduction resulting in induction of apoptosis|replicative senescence	PML body	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity	p.S372S(1)		central_nervous_system(17)|stomach(1)|ovary(1)|lung(1)	20						CCAAAATCTTGGAGTGCCCAA	0.413		NaN	F			breast 		Direct_reversal_of_damage|Other_conserved_DNA_damage_response_genes	Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|CHEK2-associated_cancer				0	0	0	0.047766	0	6	51									
SLC35E4	339665	broad.mit.edu	37	22	31032724	31032724	+	Missense_Mutation	SNP	G	G	A			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr22:31032724G>A	uc003ais.1	+	1	932	c.287G>A	c.(286-288)CGG>CAG	p.R96Q	SLC35E4_uc003ait.2_Missense_Mutation_p.R84Q	NM_001001479	NP_001001479	Q6ICL7	S35E4_HUMAN	solute carrier family 35, member E4	96						integral to membrane					0						GCATGCCACCGGGGGGCACGG	0.662		NaN											0	0	0	0.080935	0	12	3									
LRRN1	57633	broad.mit.edu	37	3	3886952	3886952	+	Missense_Mutation	SNP	G	G	A			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr3:3886952G>A	uc003bpt.3	+	2	1388	c.627G>A	c.(625-627)ATG>ATA	p.M209I	SUMF1_uc003bps.1_Intron	NM_020873	NP_065924	Q6UXK5	LRRN1_HUMAN	leucine rich repeat neuronal 1 precursor	209	Extracellular (Potential).|LRR 6.					integral to membrane				central_nervous_system(1)	1				Epithelial(13;0.000886)|all cancers(10;0.0032)|OV - Ovarian serous cystadenocarcinoma(96;0.00608)|STAD - Stomach adenocarcinoma(44;0.0617)		TTCTGGATATGAACTTCAAAC	0.413		NaN											0	0	0	0.139131	0	89	158									
DCLK3	85443	broad.mit.edu	37	3	36779198	36779198	+	Missense_Mutation	SNP	G	G	A			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr3:36779198G>A	uc003cgi.2	-	2	1444	c.953C>T	c.(952-954)CCT>CTT	p.P318L		NM_033403	NP_208382	Q9C098	DCLK3_HUMAN	doublecortin-like kinase 3	318						cytoplasm|nucleus	ATP binding|protein serine/threonine kinase activity			lung(3)|large_intestine(2)|breast(1)|skin(1)|ovary(1)|kidney(1)	9						TAGCTTTGCAGGTTGGTCATC	0.567		NaN											0	0	0	0.139131	0	53	131									
ZNF502	91392	broad.mit.edu	37	3	44762896	44762896	+	Missense_Mutation	SNP	C	C	T			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr3:44762896C>T	uc011baa.1	+	4	842	c.587C>T	c.(586-588)TCA>TTA	p.S196L	ZNF502_uc003cns.2_Missense_Mutation_p.S196L|ZNF502_uc011bab.1_Missense_Mutation_p.S196L|ZNF502_uc003cnt.2_Missense_Mutation_p.S196L	NM_001134440	NP_001127912	Q8TBZ5	ZN502_HUMAN	zinc finger protein 502	196	C2H2-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				BRCA - Breast invasive adenocarcinoma(193;0.00855)|KIRC - Kidney renal clear cell carcinoma(197;0.0471)|Kidney(197;0.0589)		AGTCGTAGTTCATTCCTTGTT	0.428		NaN											0	0	0	0.139131	0	70	159									
CDC25A	993	broad.mit.edu	37	3	48224431	48224431	+	Missense_Mutation	SNP	C	C	A			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr3:48224431C>A	uc003csh.1	-	5	781	c.417G>T	c.(415-417)GAG>GAT	p.E139D	CDC25A_uc003csi.1_Missense_Mutation_p.E139D	NM_001789	NP_001780	P30304	MPIP1_HUMAN	cell division cycle 25A isoform a	139					cell cycle checkpoint|cell division|cell proliferation|cellular response to UV|DNA replication|G1/S transition of mitotic cell cycle|G2/M transition of mitotic cell cycle|mitosis|regulation of cyclin-dependent protein kinase activity|S phase of mitotic cell cycle	cytosol|nucleoplasm	protein binding|protein tyrosine phosphatase activity			lung(3)|kidney(1)|skin(1)	5				BRCA - Breast invasive adenocarcinoma(193;0.000685)|KIRC - Kidney renal clear cell carcinoma(197;0.00596)|Kidney(197;0.00684)		TTTCCTTGTTCTCATCTGGGT	0.483		NaN											1	0	3.73148e-12	0.125774	4.09971e-12	29	61									
CELSR3	1951	broad.mit.edu	37	3	48682555	48682555	+	Missense_Mutation	SNP	G	G	A			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr3:48682555G>A	uc003cul.2	-	25	8166	c.7885C>T	c.(7885-7887)CGC>TGC	p.R2629C	CELSR3_uc003cuf.1_Missense_Mutation_p.R2726C|CELSR3_uc010hkf.2_5'Flank|CELSR3_uc010hkg.2_Missense_Mutation_p.R612C	NM_001407	NP_001398	Q9NYQ7	CELR3_HUMAN	cadherin EGF LAG seven-pass G-type receptor 3	2629	Cytoplasmic (Potential).				homophilic cell adhesion|multicellular organismal development|neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			ovary(5)|upper_aerodigestive_tract(2)|central_nervous_system(2)|skin(2)	11				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		ACCTGCATGCGGTAGAGGTGC	0.657		NaN											0	0	0	0.146539	0	14	22									
C3orf63	23272	broad.mit.edu	37	3	56662575	56662575	+	Missense_Mutation	SNP	A	A	G			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr3:56662575A>G	uc003did.3	-	18	3733	c.3632T>C	c.(3631-3633)TTA>TCA	p.L1211S	C3orf63_uc003dib.3_Missense_Mutation_p.L330S|C3orf63_uc003dic.3_Missense_Mutation_p.L835S|C3orf63_uc003die.3_Missense_Mutation_p.L1272S	NM_015224	NP_056039	Q9UK61	CC063_HUMAN	retinoblastoma-associated protein 140 isoform b	1272										ovary(3)|kidney(1)|central_nervous_system(1)	5				KIRC - Kidney renal clear cell carcinoma(284;0.0126)|Kidney(284;0.0147)		TAGTTTATCTAATTTTGATCT	0.274		NaN											0	0	0	0.132662	0	16	41									
ATP13A3	79572	broad.mit.edu	37	3	194174455	194174455	+	Missense_Mutation	SNP	G	G	A			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr3:194174455G>A	uc003fty.3	-	9	1220	c.818C>T	c.(817-819)TCA>TTA	p.S273L	ATP13A3_uc003ftz.1_5'Flank	NM_024524	NP_078800	Q9H7F0	AT133_HUMAN	ATPase type 13A3	273					ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			ovary(1)	1	all_cancers(143;6.01e-09)|Ovarian(172;0.0634)	Melanoma(1037;0.211)	OV - Ovarian serous cystadenocarcinoma(49;3.83e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;5.98e-05)		TCTACAAACTGAAACTCTTAC	0.348		NaN											0	0	0	0.204396	0	19	24									
TNK2	10188	broad.mit.edu	37	3	195599181	195599181	+	Missense_Mutation	SNP	G	G	C			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr3:195599181G>C	uc003fvu.1	-	10	1960	c.1417C>G	c.(1417-1419)CGC>GGC	p.R473G	TNK2_uc003fvq.1_5'Flank|TNK2_uc003fvr.1_5'UTR|TNK2_uc003fvs.1_Missense_Mutation_p.R505G|TNK2_uc003fvt.1_Missense_Mutation_p.R536G|TNK2_uc010hzw.1_RNA|TNK2_uc003fvv.1_Missense_Mutation_p.R303G	NM_005781	NP_005772	Q07912	ACK1_HUMAN	tyrosine kinase, non-receptor, 2 isoform 1	473				Missing (in Ref. 4; AAH08884).	positive regulation of peptidyl-tyrosine phosphorylation|protein ubiquitination|small GTPase mediated signal transduction	adherens junction|cytoplasmic vesicle membrane|endosome|nucleus	ATP binding|GTPase inhibitor activity|metal ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding			ovary(3)|central_nervous_system(3)|lung(2)|stomach(1)|skin(1)	10	all_cancers(143;6.48e-09)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;1.46e-22)|OV - Ovarian serous cystadenocarcinoma(49;8.3e-19)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;0.000757)	Adenosine triphosphate(DB00171)	CAGCAGTGGCGGGGGTCACTG	0.677		NaN											0	0	0	0.038147	0	8	18									
PAK2	5062	broad.mit.edu	37	3	196530009	196530009	+	Missense_Mutation	SNP	A	A	C			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr3:196530009A>C	uc003fwy.3	+	4	732	c.410A>C	c.(409-411)CAG>CCG	p.Q137P		NM_002577	NP_002568	Q13177	PAK2_HUMAN	p21-activated kinase 2	137	Autoregulatory region (By similarity).				axon guidance|cellular component disassembly involved in apoptosis|interspecies interaction between organisms|negative regulation of protein kinase activity|peptidyl-serine phosphorylation|positive regulation of peptidyl-tyrosine phosphorylation|protein autophosphorylation|regulation of apoptosis|regulation of defense response to virus by virus|regulation of growth|T cell costimulation|T cell receptor signaling pathway|viral reproduction	cytosol|nucleus|perinuclear region of cytoplasm|plasma membrane	ATP binding|identical protein binding|protein kinase binding|protein serine/threonine kinase activity|protein tyrosine kinase activator activity			ovary(1)|lung(1)	2	all_cancers(143;1.8e-08)|Ovarian(172;0.0634)|Breast(254;0.135)		Epithelial(36;1.07e-23)|all cancers(36;6.38e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.5e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00405)		ACAGTGAAGCAGAAATATCTG	0.428		NaN											0	0	0	0.203993	0	36	19									
LMLN	89782	broad.mit.edu	37	3	197712742	197712742	+	Missense_Mutation	SNP	C	C	T			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr3:197712742C>T	uc011buo.1	+	8	932	c.910C>T	c.(910-912)CTC>TTC	p.L304F	LMLN_uc003fyt.2_Missense_Mutation_p.L252F|LMLN_uc010iar.2_Missense_Mutation_p.L304F|LMLN_uc010ias.2_Missense_Mutation_p.L252F|LMLN_uc003fyu.2_Missense_Mutation_p.L64F	NM_033029	NP_149018	Q96KR4	LMLN_HUMAN	leishmanolysin-like isoform 2	304					cell adhesion|cell division|mitosis|proteolysis	cytoplasm|membrane	metalloendopeptidase activity|zinc ion binding			skin(1)	1	all_cancers(143;1.15e-09)|Ovarian(172;0.0418)|Breast(254;0.0976)	Lung NSC(153;0.132)	Epithelial(36;9.84e-24)|all cancers(36;3.18e-22)|OV - Ovarian serous cystadenocarcinoma(49;5.35e-19)|LUSC - Lung squamous cell carcinoma(58;6.94e-07)|Lung(62;9.92e-07)	GBM - Glioblastoma multiforme(93;0.111)		TGCAGATGGCCTCCCACCTTT	0.378		NaN											0	0	0	0.189662	0	17	10									
ACOX3	8310	broad.mit.edu	37	4	8412072	8412072	+	Missense_Mutation	SNP	A	A	G			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr4:8412072A>G	uc010idk.2	-	6	699	c.554T>C	c.(553-555)ATA>ACA	p.I185T	ACOX3_uc003glc.3_Missense_Mutation_p.I185T|ACOX3_uc003gld.3_Missense_Mutation_p.I185T|ACOX3_uc003gle.1_Missense_Mutation_p.I90T	NM_003501	NP_003492	O15254	ACOX3_HUMAN	acyl-Coenzyme A oxidase 3 isoform a	185					bile acid metabolic process|fatty acid beta-oxidation using acyl-CoA oxidase	peroxisomal matrix	acyl-CoA dehydrogenase activity|flavin adenine dinucleotide binding|pristanoyl-CoA oxidase activity			central_nervous_system(1)	1						AGGGGAATGTATGATGAATTC	0.438		NaN											0	0	0	0.116897	0	27	16									
C4orf14	84273	broad.mit.edu	37	4	57842668	57842668	+	Missense_Mutation	SNP	C	C	T			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr4:57842668C>T	uc003hck.2	-	1	1159	c.1084G>A	c.(1084-1086)GAT>AAT	p.D362N	POLR2B_uc003hcl.1_5'Flank|POLR2B_uc011cae.1_5'Flank|POLR2B_uc011caf.1_5'Flank	NM_032313	NP_115689	Q8NC60	CD014_HUMAN	hypothetical protein LOC84273	362							GTP binding			ovary(1)|breast(1)	2	Glioma(25;0.08)|all_neural(26;0.181)					GTGCAGTAATCGGACTCCAGG	0.607		NaN											0	0	0	0.105934	0	14	14									
HSD17B11	51170	broad.mit.edu	37	4	88312220	88312220	+	Missense_Mutation	SNP	C	C	T			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr4:88312220C>T	uc003hqp.2	-	1	236	c.3G>A	c.(1-3)ATG>ATA	p.M1I		NM_016245	NP_057329	Q8NBQ5	DHB11_HUMAN	estradiol 17-beta-dehydrogenase 11	1					androgen catabolic process|steroid biosynthetic process	cytoplasm|extracellular region	binding|estradiol 17-beta-dehydrogenase activity			ovary(2)	2		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.242)		OV - Ovarian serous cystadenocarcinoma(123;0.000339)		GAAGAAATTTCATCCCTTTTG	0.428		NaN											0	0	0	0.09319	0	13	9									
SDHA	6389	broad.mit.edu	37	5	236602	236602	+	Silent	SNP	G	G	A			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr5:236602G>A	uc003jao.3	+	10	1435	c.1320G>A	c.(1318-1320)GAG>GAA	p.E440E	SDHA_uc011clv.1_Silent_p.E440E|SDHA_uc011clw.1_Silent_p.E392E|SDHA_uc003jap.3_Silent_p.E440E|SDHA_uc003jaq.3_Silent_p.E215E|SDHA_uc003jar.3_Silent_p.E34E	NM_004168	NP_004159	P31040	DHSA_HUMAN	succinate dehydrogenase complex, subunit A,	440		FAD (By similarity).			nervous system development|respiratory electron transport chain|succinate metabolic process|transport|tricarboxylic acid cycle	mitochondrial respiratory chain complex II	electron carrier activity|flavin adenine dinucleotide binding|protein binding|succinate dehydrogenase (ubiquinone) activity				0			Epithelial(17;0.0159)|all cancers(22;0.0236)|OV - Ovarian serous cystadenocarcinoma(19;0.0674)|Lung(60;0.113)		Succinic acid(DB00139)	CCTGTGGGGAGGCCGCCTGTG	0.592		NaN							Familial_Paragangliomas				0	0	0	0.189662	0	20	47									
SLC6A3	6531	broad.mit.edu	37	5	1406324	1406324	+	Silent	SNP	C	C	A			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr5:1406324C>A	uc003jck.2	-	12	1699	c.1578G>T	c.(1576-1578)CTG>CTT	p.L526L		NM_001044	NP_001035	Q01959	SC6A3_HUMAN	solute carrier family 6 (neurotransmitter	526	Helical; Name=11; (Potential).				cell death|neurotransmitter biosynthetic process	axon|cytoplasm|integral to plasma membrane|neuronal cell body				ovary(3)|breast(2)|pancreas(1)	6			OV - Ovarian serous cystadenocarcinoma(19;0.00928)|all cancers(22;0.0262)		Amphetamine(DB00182)|Benztropine(DB00245)|Bupropion(DB01156)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dextroamphetamine(DB01576)|Diethylpropion(DB00937)|Duloxetine(DB00476)|Fencamfamine(DB01463)|Mazindol(DB00579)|Methylphenidate(DB00422)|Modafinil(DB00745)|Phenmetrazine(DB00830)|Phentermine(DB00191)|Procaine(DB00721)	AGGGGCTGACCAGCTTCCAGC	0.672		NaN											1	0	2.42023e-17	0.183431	2.73094e-17	36	52									
GDNF	2668	broad.mit.edu	37	5	37834771	37834771	+	Missense_Mutation	SNP	G	G	A			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr5:37834771G>A	uc011cpi.1	-	2	328	c.128C>T	c.(127-129)GCG>GTG	p.A43V	GDNF_uc011cpc.1_Intron|GDNF_uc011cpd.1_Intron|GDNF_uc011cpe.1_Intron|GDNF_uc011cpf.1_Intron|GDNF_uc011cpg.1_Missense_Mutation_p.A60V|GDNF_uc011cph.1_Intron	NM_000514	NP_000505	P39905	GDNF_HUMAN	glial cell derived neurotrophic factor isoform 1	43					adult locomotory behavior|anti-apoptosis|axon guidance|branching involved in ureteric bud morphogenesis|enteric nervous system development|mRNA stabilization|negative regulation of neuron apoptosis|neural crest cell migration|peristalsis|positive regulation of branching involved in ureteric bud morphogenesis|positive regulation of dopamine secretion|positive regulation of monooxygenase activity|positive regulation of transcription from RNA polymerase II promoter|positive regulation of ureteric bud formation|postganglionic parasympathetic nervous system development|regulation of dopamine uptake|signal transduction|sympathetic nervous system development	extracellular region	growth factor activity|protein homodimerization activity				0	all_lung(31;0.00118)					CGCGAAGGGCGCGCGGCGGCG	0.657		NaN											0	0	0	0.115264	0	3	16									
GPR98	84059	broad.mit.edu	37	5	89990019	89990019	+	Nonsense_Mutation	SNP	C	C	A			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr5:89990019C>A	uc003kju.2	+	33	7542	c.7446C>A	c.(7444-7446)TAC>TAA	p.Y2482*	GPR98_uc003kjt.2_Nonsense_Mutation_p.Y188*|GPR98_uc003kjv.2_Nonsense_Mutation_p.Y82*	NM_032119	NP_115495	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98 precursor	2482	Extracellular (Potential).				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(11)|central_nervous_system(3)|pancreas(2)	16		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		TCTGGACCTACAGGAAAAACA	0.493		NaN											1	0	0.000157383	0.038147	0.000160262	8	47									
REEP5	7905	broad.mit.edu	37	5	112257852	112257852	+	Silent	SNP	G	G	A			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr5:112257852G>A	uc003kqe.1	-	1	180	c.36C>T	c.(34-36)TTC>TTT	p.F12F	REEP5_uc011cvw.1_5'Flank|REEP5_uc011cvx.1_RNA|REEP5_uc011cvy.1_Silent_p.F12F|REEP5_uc011cvz.1_RNA	NM_005669	NP_005660	Q00765	REEP5_HUMAN	receptor accessory protein 5	12						integral to membrane	protein binding				0		all_cancers(142;4.41e-05)|all_epithelial(76;3.65e-07)|Colorectal(10;0.00115)|Prostate(80;0.00133)|Ovarian(225;0.0443)		Epithelial(69;1.3e-09)|OV - Ovarian serous cystadenocarcinoma(64;1.26e-08)|all cancers(49;3.56e-07)|Colorectal(14;0.00778)|COAD - Colon adenocarcinoma(37;0.013)		TCTCGTGCAGGAACCGGTCGA	0.647		NaN											0	0	0	0.184627	0	5	21									
PSD2	84249	broad.mit.edu	37	5	139193876	139193876	+	Missense_Mutation	SNP	C	C	G			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr5:139193876C>G	uc003leu.1	+	4	1148	c.943C>G	c.(943-945)CAT>GAT	p.H315D		NM_032289	NP_115665	Q9BQI7	PSD2_HUMAN	pleckstrin and Sec7 domain containing 2	315	SEC7.				regulation of ARF protein signal transduction	cytoplasm|integral to membrane	ARF guanyl-nucleotide exchange factor activity			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGAAGCTGCTCATCGGCTGGC	0.647		NaN											0	0	0	0.219247	0	22	38									
PCDHA2	56146	broad.mit.edu	37	5	140176494	140176494	+	Missense_Mutation	SNP	G	G	A			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr5:140176494G>A	uc003lhd.2	+	1	2051	c.1945G>A	c.(1945-1947)GTG>ATG	p.V649M	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhc.1_Missense_Mutation_p.V649M|PCDHA2_uc011czy.1_Missense_Mutation_p.V649M	NM_018905	NP_061728	Q9Y5H9	PCDA2_HUMAN	protocadherin alpha 2 isoform 1 precursor	649	Cadherin 6.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(4)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCGCCTACTCGTGCTGGTGAA	0.652		NaN											0	0	0	0.11911	0	15	68									
PCDHB1	29930	broad.mit.edu	37	5	140431567	140431567	+	Missense_Mutation	SNP	C	C	A			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr5:140431567C>A	uc003lik.1	+	1	589	c.512C>A	c.(511-513)ACC>AAC	p.T171N		NM_013340	NP_037472	Q9Y5F3	PCDB1_HUMAN	protocadherin beta 1 precursor	171	Cadherin 2.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CAGAACTACACCCTGAGTGCC	0.567		NaN											1	0	7.93312e-07	0.11911	8.33227e-07	12	75									
PCDHGA12	26025	broad.mit.edu	37	5	140811312	140811312	+	Missense_Mutation	SNP	C	C	T			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr5:140811312C>T	uc003lkt.1	+	1	1155	c.986C>T	c.(985-987)GCG>GTG	p.A329V	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc003lkh.1_Intron|PCDHGB6_uc003lkj.1_Intron|PCDHGA10_uc003lkl.1_Intron|PCDHGB7_uc003lkn.1_Intron|PCDHGA11_uc003lkp.1_Intron|PCDHGA11_uc003lkq.1_Intron|PCDHGA12_uc011dba.1_Missense_Mutation_p.A329V	NM_003735	NP_003726	O60330	PCDGC_HUMAN	protocadherin gamma subfamily A, 12 isoform 1	329	Cadherin 3.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)|pancreas(1)|skin(1)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGATATTCTGCGCGAGCCAAA	0.507		NaN											0	0	0	0.139131	0	50	71									
PWWP2A	114825	broad.mit.edu	37	5	159520621	159520621	+	Missense_Mutation	SNP	A	A	G			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr5:159520621A>G	uc011ded.1	-	2	1093	c.1036T>C	c.(1036-1038)TCT>CCT	p.S346P	PWWP2A_uc003lxv.3_Missense_Mutation_p.S346P|PWWP2A_uc011dec.1_Missense_Mutation_p.S346P	NM_001130864	NP_001124336	Q96N64	PWP2A_HUMAN	PWWP domain containing 2A isoform b	346											0	Renal(175;0.00196)	Medulloblastoma(196;0.0354)|all_neural(177;0.138)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			TCATATTTAGAAGAGTCAGTT	0.328		NaN											0	0	0	0.047766	0	9	32									
SH3PXD2B	285590	broad.mit.edu	37	5	171773245	171773245	+	Silent	SNP	C	C	T			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr5:171773245C>T	uc003mbr.2	-	12	1254	c.1083G>A	c.(1081-1083)CCG>CCA	p.P361P		NM_001017995	NP_001017995	A1X283	SPD2B_HUMAN	SH3 and PX domains 2B	361					adipose tissue development|bone development|cell communication|cell differentiation|eye development|heart development|podosome assembly	cell junction|cell projection|cytoplasm|podosome	phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-5-phosphate binding|SH2 domain binding			ovary(3)|skin(1)	4	Renal(175;0.000159)|Lung NSC(126;0.011)|all_lung(126;0.0175)	Medulloblastoma(196;0.0207)|all_neural(177;0.0625)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			TGGGCGGCTTCGGCAGGTTGA	0.597		NaN											0	0	0	0.26419	0	25	105									
SQSTM1	8878	broad.mit.edu	37	5	179263587	179263587	+	Silent	SNP	G	G	A	rs11548636		TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr5:179263587G>A	uc003mkw.3	+	8	1412	c.1317G>A	c.(1315-1317)CCG>CCA	p.P439P	SQSTM1_uc011dgr.1_Silent_p.P355P|SQSTM1_uc011dgs.1_Silent_p.P355P|SQSTM1_uc003mkv.3_Missense_Mutation_p.R356H|SQSTM1_uc003mkx.2_Silent_p.P355P	NM_003900	NP_003891	Q13501	SQSTM_HUMAN	sequestosome 1 isoform 1	439	Interaction with NTRK1 (By similarity).				anti-apoptosis|apoptosis|cell differentiation|endosome transport|induction of apoptosis by extracellular signals|intracellular signal transduction|macroautophagy|nerve growth factor receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|protein localization|regulation of I-kappaB kinase/NF-kappaB cascade|ubiquitin-dependent protein catabolic process	cytosol|late endosome|nucleoplasm	protein kinase C binding|receptor tyrosine kinase binding|SH2 domain binding|ubiquitin binding|zinc ion binding		SQSTM1/ALK(2)	haematopoietic_and_lymphoid_tissue(2)|ovary(1)	3	all_cancers(89;0.000205)|all_epithelial(37;7.15e-05)|Renal(175;0.000159)|Lung NSC(126;0.00136)|all_lung(126;0.00243)	all_cancers(40;0.0395)|Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			ATCCCCCGCCGTTGTGACCAC	0.542		NaN							Paget_Disease_of_Bone				0	0	0	0.139131	0	48	56									
BTNL9	153579	broad.mit.edu	37	5	180486555	180486555	+	Missense_Mutation	SNP	C	C	T			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr5:180486555C>T	uc003mmt.2	+	11	1532	c.1301C>T	c.(1300-1302)GCC>GTC	p.A434V		NM_152547	NP_689760	Q6UXG8	BTNL9_HUMAN	butyrophilin-like 9 precursor	434	Cytoplasmic (Potential).|B30.2/SPRY.					integral to membrane				ovary(1)|central_nervous_system(1)	2	all_cancers(89;2.45e-05)|all_epithelial(37;3.77e-06)|Renal(175;0.000159)|Lung NSC(126;0.00211)|all_lung(126;0.00371)|Breast(19;0.114)	all_cancers(40;0.0801)|Medulloblastoma(196;0.0392)|all_neural(177;0.0529)|all_hematologic(541;0.191)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			TTCGTCCTGGCCCCGCACCGC	0.741		NaN											0	0	0	0.146539	0	16	17									
RANBP9	10048	broad.mit.edu	37	6	13639851	13639851	+	Missense_Mutation	SNP	T	T	C			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr6:13639851T>C	uc003nbb.2	-	9	1528	c.1469A>G	c.(1468-1470)CAT>CGT	p.H490R	RANBP9_uc003nba.2_Missense_Mutation_p.H149R	NM_005493	NP_005484	Q96S59	RANB9_HUMAN	RAN binding protein 9	490					axon guidance|microtubule nucleation|protein complex assembly	cytosol|microtubule associated complex|nucleus	Ran GTPase binding			lung(1)|skin(1)	2	Breast(50;0.00669)|Ovarian(93;0.0634)	all_hematologic(90;0.117)	Epithelial(50;0.223)			ATTCATTCCATGGCTGGGGCT	0.403		NaN											0	0	0	0.173368	0	33	45									
MICB	4277	broad.mit.edu	37	6	31477644	31477644	+	Silent	SNP	G	G	C			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr6:31477644G>C	uc003ntn.3	+	6	1226	c.1110G>C	c.(1108-1110)CTG>CTC	p.L370L	MICB_uc011dnm.1_Silent_p.L338L|MICB_uc003nto.3_Silent_p.L327L	NM_005931	NP_005922	Q29980	MICB_HUMAN	MHC class I polypeptide-related sequence B	370	Cytoplasmic (Potential).				antigen processing and presentation|cytolysis|gamma-delta T cell activation|immune response|immune response-activating cell surface receptor signaling pathway|interspecies interaction between organisms|negative regulation of defense response to virus by host|response to heat|response to oxidative stress|response to retinoic acid	integral to plasma membrane|MHC class I protein complex	natural killer cell lectin-like receptor binding				0						TTCAGCCTCTGATGTCAGCTA	0.577		NaN											0	0	0	0.203993	0	39	54									
FTSJD2	23070	broad.mit.edu	37	6	37429339	37429339	+	Silent	SNP	G	G	A			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr6:37429339G>A	uc003ons.2	+	11	1363	c.1110G>A	c.(1108-1110)GAG>GAA	p.E370E	FTSJD2_uc010jwu.2_Silent_p.E314E	NM_015050	NP_055865	Q8N1G2	MTR1_HUMAN	FtsJ methyltransferase domain containing 2	370					mRNA capping	cytoplasm|nucleus	mRNA (nucleoside-2'-O-)-methyltransferase activity|nucleic acid binding	p.E370D(1)		ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	5						TCTCGGTGGAGGGGCAGGAGA	0.512		NaN											0	0	0	0.184627	0	5	31									
MRPS10	55173	broad.mit.edu	37	6	42179605	42179605	+	Missense_Mutation	SNP	C	C	G			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr6:42179605C>G	uc003osa.3	-	4	283	c.237G>C	c.(235-237)TTG>TTC	p.L79F	MRPS10_uc011dup.1_Missense_Mutation_p.L38F	NM_018141	NP_060611	P82664	RT10_HUMAN	mitochondrial ribosomal protein S10	79					translation	actin cytoskeleton|mitochondrion|ribosome	structural constituent of ribosome				0	Colorectal(47;0.196)		Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)|Epithelial(12;0.00528)			GACCTTTCACCAAAACCGAGA	0.363		NaN											0	0	0	0.108266	0	28	48									
HNRNPA2B1	3181	broad.mit.edu	37	7	26237281	26237281	+	Silent	SNP	C	C	T			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr7:26237281C>T	uc003sxr.3	-	3	330	c.114G>A	c.(112-114)AGG>AGA	p.R38R	HNRNPA2B1_uc003sxs.3_Silent_p.R26R	NM_031243	NP_112533	P22626	ROA2_HUMAN	heterogeneous nuclear ribonucleoprotein A2/B1	38	RRM 1.				RNA transport	catalytic step 2 spliceosome|cytoplasm|heterogeneous nuclear ribonucleoprotein complex|nucleolus|nucleoplasm	nucleotide binding|protein binding|protein binding|RNA binding|single-stranded telomeric DNA binding			ovary(1)|central_nervous_system(1)|skin(1)	3						CGTAGTAGTTCCTCAAACTTT	0.353		NaN	T	ETV1	prostate								0	0	0	0.160694	0	15	54									
GLI3	2737	broad.mit.edu	37	7	42005031	42005031	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr7:42005031G>A	uc011kbh.1	-	15	3731	c.3640C>T	c.(3640-3642)CAG>TAG	p.Q1214*	GLI3_uc011kbg.1_Nonsense_Mutation_p.Q1155*	NM_000168	NP_000159	P10071	GLI3_HUMAN	GLI-Kruppel family member GLI3	1214					negative regulation of alpha-beta T cell differentiation|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of smoothened signaling pathway|negative regulation of transcription from RNA polymerase II promoter|negative thymic T cell selection|positive regulation of alpha-beta T cell differentiation|positive regulation of transcription from RNA polymerase II promoter|thymocyte apoptosis	cilium|cytosol|nucleolus	beta-catenin binding|histone acetyltransferase binding|histone deacetylase binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(11)|ovary(3)|large_intestine(2)|central_nervous_system(1)|kidney(1)|pancreas(1)	19						CCGAGGGTCTGATAGCCCCCA	0.652		NaN							Greig_Cephalopolysyndactyly|Pallister-Hall_syndrome				0	0	0	0.124865	0	47	69									
CCM2	83605	broad.mit.edu	37	7	45108111	45108111	+	Missense_Mutation	SNP	C	C	A			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr7:45108111C>A	uc003tmo.2	+	5	688	c.542C>A	c.(541-543)TCC>TAC	p.S181Y	CCM2_uc003tmn.2_RNA|CCM2_uc003tmp.2_Missense_Mutation_p.S123Y|CCM2_uc003tmq.2_RNA|CCM2_uc003tmr.2_Intron|CCM2_uc011kcb.1_Missense_Mutation_p.S144Y|CCM2_uc011kcc.1_Intron|CCM2_uc003tms.2_Missense_Mutation_p.S202Y	NM_031443	NP_113631	Q9BSQ5	CCM2_HUMAN	cerebral cavernous malformation 2 isoform 2	181	PID.				endothelial tube morphogenesis|integrin-mediated signaling pathway|stress-activated MAPK cascade|vasculogenesis	cytoplasm	protein binding				0						AGTGCAGGCTCCCTGTCGGAG	0.592		NaN							Familial_Cerebral_Cavernous_Angioma				1	0	6.1207e-33	0.131918	7.00107e-33	46	62									
POM121L12	285877	broad.mit.edu	37	7	53103824	53103824	+	Missense_Mutation	SNP	C	C	T			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr7:53103824C>T	uc003tpz.2	+	1	476	c.460C>T	c.(460-462)CCT>TCT	p.P154S		NM_182595	NP_872401	Q8N7R1	P1L12_HUMAN	POM121 membrane glycoprotein-like 12	154											0						CTGGAGATCCCCTGGACAGAG	0.592		NaN											0	0	0	0.09319	0	13	27									
MAGI2	9863	broad.mit.edu	37	7	78130897	78130897	+	Missense_Mutation	SNP	A	A	G			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr7:78130897A>G	uc003ugx.2	-	5	1216	c.962T>C	c.(961-963)ATT>ACT	p.I321T	MAGI2_uc003ugy.2_Missense_Mutation_p.I321T|MAGI2_uc011kgr.1_Missense_Mutation_p.I153T|MAGI2_uc011kgs.1_Missense_Mutation_p.I158T	NM_012301	NP_036433	Q86UL8	MAGI2_HUMAN	membrane associated guanylate kinase, WW and PDZ	321	WW 1.|Interaction with DDN.					cell junction|synapse|synaptosome	phosphatase binding			ovary(5)|lung(4)|breast(1)|skin(1)	11		all_cancers(73;0.0064)|all_epithelial(88;0.087)|all_neural(109;0.0936)|Medulloblastoma(109;0.166)|Melanoma(862;0.236)				AACTCACTCAATGAAGTAGAC	0.388		NaN											0	0	0	0.146539	0	17	67									
PCLO	27445	broad.mit.edu	37	7	82580339	82580339	+	Missense_Mutation	SNP	C	C	T			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr7:82580339C>T	uc003uhx.2	-	6	9854	c.9565G>A	c.(9565-9567)GAA>AAA	p.E3189K	PCLO_uc003uhv.2_Missense_Mutation_p.E3189K|PCLO_uc010lec.2_Missense_Mutation_p.E154K	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	3120					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						GGAAACACTTCGGATGCTGTG	0.443		NaN											0	0	0	0.080935	0	12	18									
ADAM22	53616	broad.mit.edu	37	7	87762258	87762258	+	Missense_Mutation	SNP	G	G	A			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr7:87762258G>A	uc003ujn.2	+	12	1148	c.1069G>A	c.(1069-1071)GTG>ATG	p.V357M	ADAM22_uc003ujk.1_Missense_Mutation_p.V357M|ADAM22_uc003ujl.1_Missense_Mutation_p.V357M|ADAM22_uc003ujm.2_Missense_Mutation_p.V357M|ADAM22_uc003ujo.2_Missense_Mutation_p.V357M|ADAM22_uc003ujp.1_Missense_Mutation_p.V409M	NM_021723	NP_068369	Q9P0K1	ADA22_HUMAN	ADAM metallopeptidase domain 22 isoform 1	357	Peptidase M12B.|Extracellular (Potential).				cell adhesion|central nervous system development|negative regulation of cell adhesion|proteolysis	integral to membrane	integrin binding|metalloendopeptidase activity|protein binding|receptor activity|zinc ion binding			ovary(4)|skin(2)|lung(1)|kidney(1)	8	Esophageal squamous(14;0.00202)		STAD - Stomach adenocarcinoma(171;0.215)			AGGAGGAGGCGTGAATGAAGT	0.398		NaN											0	0	0	0.248553	0	5	70									
ACTL6B	51412	broad.mit.edu	37	7	100244899	100244899	+	Silent	SNP	G	G	A			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr7:100244899G>A	uc003uvy.2	-	9	875	c.768C>T	c.(766-768)ATC>ATT	p.I256I	ACTL6B_uc003uvx.1_Silent_p.I47I|ACTL6B_uc003uvz.2_RNA	NM_016188	NP_057272	O94805	ACL6B_HUMAN	actin-like 6B	256					chromatin modification|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nBAF complex|SWI/SNF complex	ATP binding|protein binding|structural constituent of cytoskeleton			ovary(1)	1	Lung NSC(181;0.035)|all_lung(186;0.0509)|Esophageal squamous(72;0.0817)					GGAAGTCCTGGATCACCTCCT	0.672		NaN											0	0	0	0.249174	0	22	23									
GPR37	2861	broad.mit.edu	37	7	124386891	124386891	+	Missense_Mutation	SNP	G	G	C			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr7:124386891G>C	uc003vli.2	-	2	2181	c.1530C>G	c.(1528-1530)ATC>ATG	p.I510M		NM_005302	NP_005293	O15354	GPR37_HUMAN	G protein-coupled receptor 37 precursor	510	Helical; Name=6; (Potential).					endoplasmic reticulum membrane|integral to plasma membrane	G-protein coupled receptor activity			ovary(1)|lung(1)|central_nervous_system(1)	3						CAATGTTGCAGATATTTTCAG	0.418		NaN											0	0	0	0.234183	0	22	72									
ZNF862	643641	broad.mit.edu	37	7	149558351	149558351	+	Missense_Mutation	SNP	T	T	C			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr7:149558351T>C	uc010lpn.2	+	7	2294	c.2102T>C	c.(2101-2103)ATG>ACG	p.M701T	ZNF862_uc003wgm.2_RNA	NM_001099220	NP_001092690	O60290	ZN862_HUMAN	zinc finger protein 862	701					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|nucleic acid binding|protein dimerization activity			skin(1)	1						GGCTCAGCCATGTTGAGCTGC	0.632		NaN											0	0	0	0.115264	0	3	11									
NUB1	51667	broad.mit.edu	37	7	151042482	151042482	+	Missense_Mutation	SNP	G	G	T			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr7:151042482G>T	uc003wjx.2	+	2	124	c.119G>T	c.(118-120)AGG>ATG	p.R40M	NUB1_uc011kvi.1_Missense_Mutation_p.R40M|NUB1_uc003wjv.2_RNA|NUB1_uc003wjw.2_Missense_Mutation_p.R16M|NUB1_uc010lqb.2_RNA|NUB1_uc003wjy.2_RNA	NM_016118	NP_057202	Q9Y5A7	NUB1_HUMAN	NEDD8 ultimate buster-1	16					positive regulation of proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination|response to interferon-gamma|response to tumor necrosis factor|ubiquitin-dependent protein catabolic process	nucleus	protein binding				0			OV - Ovarian serous cystadenocarcinoma(82;0.00569)	UCEC - Uterine corpus endometrioid carcinoma (81;0.172)		CAGTTTTTAAGGGAAGACAGG	0.303		NaN											1	0	2.17888e-05	0.058154	2.24613e-05	9	21									
SGK223	157285	broad.mit.edu	37	8	8235550	8235550	+	Silent	SNP	C	C	T			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr8:8235550C>T	uc003wsh.3	-	2	369	c.369G>A	c.(367-369)CCG>CCA	p.P123P		NM_001080826	NP_001074295	Q86YV5	SG223_HUMAN	pragmin	123							ATP binding|non-membrane spanning protein tyrosine kinase activity				0						CCTCCTGCTTCGGGAGGGGGA	0.552		NaN											0	0	0	0.203993	0	36	19									
TEX15	56154	broad.mit.edu	37	8	30702216	30702216	+	Missense_Mutation	SNP	C	C	A			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr8:30702216C>A	uc003xil.2	-	1	4318	c.4318G>T	c.(4318-4320)GAT>TAT	p.D1440Y		NM_031271	NP_112561	Q9BXT5	TEX15_HUMAN	testis expressed 15	1440										ovary(3)|upper_aerodigestive_tract(2)|skin(2)	7				KIRC - Kidney renal clear cell carcinoma(542;0.0918)|Kidney(114;0.111)		TTTACATTATCTTTTAAAAGC	0.348		NaN											1	0	0.000157383	0.038147	0.000160262	8	28									
PRKDC	5591	broad.mit.edu	37	8	48690396	48690396	+	Missense_Mutation	SNP	G	G	A			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr8:48690396G>A	uc003xqi.2	-	85	11950	c.11893C>T	c.(11893-11895)CGC>TGC	p.R3965C	PRKDC_uc003xqj.2_Missense_Mutation_p.R3934C|PRKDC_uc011ldh.1_Intron	NM_006904	NP_008835	P78527	PRKDC_HUMAN	protein kinase, DNA-activated, catalytic	3965	PI3K/PI4K.				cellular response to insulin stimulus|double-strand break repair via nonhomologous end joining|peptidyl-serine phosphorylation|positive regulation of transcription from RNA polymerase II promoter	DNA-dependent protein kinase-DNA ligase 4 complex|transcription factor complex	ATP binding|DNA binding|DNA-dependent protein kinase activity|transcription factor binding			lung(12)|central_nervous_system(9)|ovary(6)|skin(4)|large_intestine(3)	34		all_cancers(86;0.0336)|all_epithelial(80;0.00111)|Lung NSC(129;0.00363)|all_lung(136;0.00391)				ATAAACTGGCGAGTTAGCCGA	0.483		NaN						NHEJ					0	0	0	0.105934	0	14	73									
SHB	6461	broad.mit.edu	37	9	37955959	37955959	+	Missense_Mutation	SNP	G	G	C			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr9:37955959G>C	uc004aax.2	-	4	1715	c.1147C>G	c.(1147-1149)CCT>GCT	p.P383A		NM_003028	NP_003019	Q15464	SHB_HUMAN	Src homology 2 domain containing adaptor protein	383	Mediates interaction with LAT, FAK1, JAK1 and JAK3.				angiogenesis|apoptosis|cell differentiation|signal transduction	cytoplasm|plasma membrane	SH3/SH2 adaptor activity			central_nervous_system(2)|skin(1)	3		all_epithelial(88;0.122)		GBM - Glioblastoma multiforme(29;3.27e-05)|Lung(182;0.0658)		TGTTTGATAGGCTTAAAGCCC	0.597		NaN											0	0	0	0.184627	0	5	2									
KIAA0368	23392	broad.mit.edu	37	9	114151916	114151916	+	Missense_Mutation	SNP	G	G	T			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr9:114151916G>T	uc004bfe.1	-	32	3901	c.3901C>A	c.(3901-3903)CGT>AGT	p.R1301S		NM_001080398	NP_001073867			KIAA0368 protein												0						AACTGGTAACGATAAAGTCGA	0.453		NaN											1	0	2.23348e-06	0.146539	2.31672e-06	17	23									
SLC46A2	57864	broad.mit.edu	37	9	115652599	115652599	+	Silent	SNP	G	G	A			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr9:115652599G>A	uc004bgk.2	-	1	595	c.363C>T	c.(361-363)CTC>CTT	p.L121L		NM_033051	NP_149040	Q9BY10	TSCOT_HUMAN	solute carrier family 46, member 2	121	Helical; Name=3; (Potential).					integral to membrane|plasma membrane	symporter activity			central_nervous_system(1)	1						GCAGCAGCCCGAGGCGGGAGA	0.677		NaN											0	0	0	0.099896	0	28	12									
ARHGAP6	395	broad.mit.edu	37	X	11206894	11206894	+	Missense_Mutation	SNP	G	G	A			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chrX:11206894G>A	uc004cup.1	-	4	1904	c.1031C>T	c.(1030-1032)TCA>TTA	p.S344L	ARHGAP6_uc004cuo.1_RNA|ARHGAP6_uc004cur.1_Missense_Mutation_p.S344L|ARHGAP6_uc004cum.1_Missense_Mutation_p.S141L|ARHGAP6_uc004cun.1_Missense_Mutation_p.S164L|ARHGAP6_uc010neb.1_Missense_Mutation_p.S166L|ARHGAP6_uc011mif.1_Missense_Mutation_p.S141L	NM_013427	NP_038286	O43182	RHG06_HUMAN	Rho GTPase activating protein 6 isoform 1	344	SH3-binding.				actin filament polymerization|activation of phospholipase C activity|negative regulation of focal adhesion assembly|negative regulation of stress fiber assembly|Rho protein signal transduction	actin filament|cytosol	phospholipase activator activity|phospholipase binding|Rho GTPase activator activity|SH3 domain binding|SH3/SH2 adaptor activity			urinary_tract(1)|lung(1)	2						TGGGGACGTTGACTCATTCGG	0.498		NaN											0	0	0	0.204396	0	19	40									
FAM47B	170062	broad.mit.edu	37	X	34960988	34960988	+	Missense_Mutation	SNP	G	G	A			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chrX:34960988G>A	uc004ddi.1	+	1	58	c.40G>A	c.(40-42)GGC>AGC	p.G14S		NM_152631	NP_689844	Q8NA70	FA47B_HUMAN	hypothetical protein LOC170062	14										ovary(3)|breast(1)	4						AAGGTCCCAAGGCATGGACTC	0.622		NaN											0	0	0	0.184627	0	5	20									
SPIN4	139886	broad.mit.edu	37	X	62570455	62570455	+	Missense_Mutation	SNP	C	C	G			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chrX:62570455C>G	uc004dvf.2	-	1	764	c.244G>C	c.(244-246)GAT>CAT	p.D82H		NM_001012968	NP_001012986	Q56A73	SPIN4_HUMAN	spindlin family, member 4	82					gamete generation					ovary(1)|lung(1)	2						TACACACTATCTTTGCCATCA	0.498		NaN											0	0	0	0.150653	0	4	17									
MED12	9968	broad.mit.edu	37	X	70349240	70349240	+	Missense_Mutation	SNP	G	G	A			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chrX:70349240G>A	uc004dyy.2	+	26	3851	c.3652G>A	c.(3652-3654)GGA>AGA	p.G1218R	MED12_uc011mpq.1_Missense_Mutation_p.G1218R|MED12_uc004dyz.2_Missense_Mutation_p.G1218R|MED12_uc004dza.2_Missense_Mutation_p.G1065R|MED12_uc010nla.2_5'Flank	NM_005120	NP_005111	Q93074	MED12_HUMAN	mediator complex subunit 12	1218					androgen receptor signaling pathway|negative regulation of Wnt receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|protein C-terminus binding|protein domain specific binding|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	4	Renal(35;0.156)					CATCGTGGATGGAGCCGTGTT	0.577		NaN									OREG0019857	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.248553	0	7	20									
SMARCA1	6594	broad.mit.edu	37	X	128638781	128638781	+	Splice_Site	SNP	T	T	C			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chrX:128638781T>C	uc004eun.3	-	9	1212	c.1099_splice	c.e9-1	p.D367_splice	SMARCA1_uc004eup.3_Splice_Site_p.D367_splice|SMARCA1_uc011muk.1_Splice_Site_p.D367_splice|SMARCA1_uc011mul.1_Splice_Site_p.D367_splice	NM_003069	NP_003060	P28370	SMCA1_HUMAN	SWI/SNF-related matrix-associated						ATP-dependent chromatin remodeling|brain development|neuron differentiation|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	NURF complex	ATP binding|DNA binding|helicase activity|nucleosome binding|protein binding			ovary(3)|skin(1)	4						ATCAAAGTCCTGTAGAGGGGT	0.343		NaN											0	0	0	0.083992	0	26	36									
CETN2	1069	broad.mit.edu	37	X	151997114	151997114	+	Missense_Mutation	SNP	C	C	A			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chrX:151997114C>A	uc004fgq.2	-	4	443	c.396G>T	c.(394-396)GAG>GAT	p.E132D	CETN2_uc004fgr.2_Missense_Mutation_p.E61D|NSDHL_uc004fgt.1_5'Flank|NSDHL_uc004fgs.1_5'Flank	NM_004344	NP_004335	P41208	CETN2_HUMAN	caltractin	132	EF-hand 3.				cell division|centriole replication|G2/M transition of mitotic cell cycle|mitosis|nucleotide-excision repair|regulation of cytokinesis	centriole|cytosol|XPC complex	ATP binding|ATP-dependent helicase activity|calcium ion binding|nucleic acid binding				0	Acute lymphoblastic leukemia(192;6.56e-05)					TCTCACCCAACTCCTTGGCCA	0.418		NaN						Direct_reversal_of_damage|NER					1	0	1.68575e-08	0.125774	1.79313e-08	28	35									
SIDT2	51092	broad.mit.edu	37	11	117064644	117064645	+	In_Frame_Ins	INS	-	-	TCT			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr11:117064644_117064645insTCT	uc001pqh.1	+	24	2328_2329	c.2287_2288insTCT	c.(2287-2289)CTC>CTCTTC	p.767_768insF	SIDT2_uc010rxe.1_In_Frame_Ins_p.767_768insF|SIDT2_uc001pqg.2_In_Frame_Ins_p.788_789insF|SIDT2_uc001pqi.1_In_Frame_Ins_p.764_765insF|SIDT2_uc001pqj.1_In_Frame_Ins_p.79_80insF	NM_001040455	NP_001035545	Q8NBJ9	SIDT2_HUMAN	SID1 transmembrane family, member 2 precursor	767_768	Cytoplasmic (Potential).					integral to membrane|lysosomal membrane					0	all_hematologic(175;0.0487)	Breast(348;0.00908)|Medulloblastoma(222;0.0425)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;1.69e-05)|Epithelial(105;0.000219)|all cancers(92;0.00144)		GGGCTTCGCGCTCTTCTTCTTC	0.604		NaN											NaN	NaN	NaN	NaN	NaN	20	26	---	---							
ZC3H18	124245	broad.mit.edu	37	16	88666210	88666211	+	Frame_Shift_Ins	INS	-	-	GC			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr16:88666210_88666211insGC	uc002fky.2	+	6	1142_1143	c.942_943insGC	c.(940-945)AAAGCAfs	p.K314fs	ZC3H18_uc010voy.1_Frame_Shift_Ins_p.K197fs|ZC3H18_uc010voz.1_Frame_Shift_Ins_p.K338fs	NM_144604	NP_653205	Q86VM9	ZCH18_HUMAN	zinc finger CCCH-type containing 18	314_315						nucleus	nucleic acid binding|zinc ion binding			skin(1)	1				BRCA - Breast invasive adenocarcinoma(80;0.0542)		TTTTAAAAAAAGCAACTATTCG	0.431		NaN											NaN	NaN	NaN	NaN	NaN	38	121	---	---							
ZDBF2	57683	broad.mit.edu	37	2	207169788	207169789	+	Frame_Shift_Ins	INS	-	-	C			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr2:207169788_207169789insC	uc002vbp.2	+	5	786_787	c.536_537insC	c.(535-537)CGCfs	p.R179fs		NM_020923	NP_065974	Q9HCK1	ZDBF2_HUMAN	zinc finger, DBF-type containing 2	179							nucleic acid binding|zinc ion binding			ovary(3)	3						AACTTGGTACGCCCCCCAGTGA	0.426		NaN											NaN	NaN	NaN	NaN	NaN	18	24	---	---							
RHBDD1	84236	broad.mit.edu	37	2	227779059	227779059	+	Frame_Shift_Del	DEL	G	G	-			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr2:227779059delG	uc002voi.2	+	6	969	c.848delG	c.(847-849)TGGfs	p.W283fs	RHBDD1_uc010fxc.2_Frame_Shift_Del_p.W283fs|RHBDD1_uc002voj.2_Frame_Shift_Del_p.W114fs	NM_032276	NP_115652	Q8TEB9	RHBD1_HUMAN	rhomboid domain containing 1	283						integral to membrane	serine-type endopeptidase activity			ovary(1)	1		Renal(207;0.023)|all_lung(227;0.13)|Esophageal squamous(248;0.23)|all_hematologic(139;0.248)		Epithelial(121;1.47e-11)|all cancers(144;1.52e-08)|Lung(261;0.0128)|LUSC - Lung squamous cell carcinoma(224;0.0175)		GCCAGCCTCTGGGACCGAGGT	0.443		NaN											NaN	NaN	NaN	NaN	NaN	21	24	---	---							
FBXO38	81545	broad.mit.edu	37	5	147781970	147781974	+	Frame_Shift_Del	DEL	TCATA	TCATA	-			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr5:147781970_147781974delTCATA	uc003lpf.1	+	5	606_610	c.486_490delTCATA	c.(484-492)GTTCATATTfs	p.V162fs	FBXO38_uc003lpg.1_Frame_Shift_Del_p.V162fs|FBXO38_uc003lph.2_Frame_Shift_Del_p.V162fs	NM_205836	NP_995308	Q6PIJ6	FBX38_HUMAN	F-box protein 38 isoform b	162_164						cytoplasm|nucleus				ovary(4)|skin(2)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGCCCCATGTTCATATTTTGGGGAA	0.346		NaN											NaN	NaN	NaN	NaN	NaN	25	67	---	---							
MLLT3	4300	broad.mit.edu	37	9	20414278	20414280	+	In_Frame_Del	DEL	CTG	CTG	-			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr9:20414278_20414280delCTG	uc003zoe.2	-	5	823_825	c.564_566delCAG	c.(562-567)AGCAGT>AGT	p.188_189SS>S	MLLT3_uc011lne.1_In_Frame_Del_p.156_157SS>S|MLLT3_uc011lnf.1_In_Frame_Del_p.185_186SS>S|MLLT3_uc003zof.2_5'UTR	NM_004529	NP_004520	P42568	AF9_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	188_189	Poly-Ser.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding			lung(2)|ovary(1)	3				GBM - Glioblastoma multiforme(3;4.35e-105)|Lung(42;3.48e-06)|LUSC - Lung squamous cell carcinoma(42;7.92e-05)		ACTGGTActactgctgctgctgc	0.182		NaN	T	MLL	ALL								NaN	NaN	NaN	NaN	NaN	7	124	---	---