Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	isArtifactMode	oxoGCut	pox	pox_cutoff	qox	t_alt_count	t_ref_count	validation_alt_allele	validation_tumor_sample							
ACAP3	116983	broad.mit.edu	37	1	1233261	1233261	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr1:1233261C>T	uc001aeb.2	-	14	1143	c.1069G>A	c.(1069-1071)GCT>ACT	p.A357T	ACAP3_uc001ady.2_Missense_Mutation_p.A87T|ACAP3_uc001aea.2_Missense_Mutation_p.A315T	NM_030649	NP_085152	Q96P50	ACAP3_HUMAN	ArfGAP with coiled-coil, ankyrin repeat and PH	357	PH.				filopodium assembly|regulation of ARF GTPase activity|signal transduction		ARF GTPase activator activity|cytoskeletal adaptor activity|SH3 domain binding|zinc ion binding				0						GCCTGCACAGCCTGGACCCAG	0.687		NaN											0	0	0	0.007413	0	18	22									
RER1	11079	broad.mit.edu	37	1	2327262	2327262	+	Silent	SNP	C	C	T			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr1:2327262C>T	uc001aje.1	+	2	224	c.33C>T	c.(31-33)GTC>GTT	p.V11V	RER1_uc001ajf.1_Silent_p.V11V	NM_007033	NP_008964	O15258	RER1_HUMAN	RER1 retention in endoplasmic reticulum 1	11					retrograde vesicle-mediated transport, Golgi to ER	integral to Golgi membrane					0	all_cancers(77;0.000247)|all_epithelial(69;9.96e-05)|all_lung(157;0.016)|Lung NSC(156;0.0376)|Ovarian(185;0.0634)	all_epithelial(116;5.35e-20)|all_lung(118;2.78e-08)|Lung NSC(185;2.69e-06)|Breast(487;0.00147)|Renal(390;0.00183)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Medulloblastoma(700;0.123)|Lung SC(97;0.128)		Epithelial(90;2.28e-37)|OV - Ovarian serous cystadenocarcinoma(86;8.29e-23)|GBM - Glioblastoma multiforme(42;4.71e-08)|Colorectal(212;4.73e-05)|COAD - Colon adenocarcinoma(227;0.00021)|Kidney(185;0.00116)|BRCA - Breast invasive adenocarcinoma(365;0.00459)|STAD - Stomach adenocarcinoma(132;0.00645)|KIRC - Kidney renal clear cell carcinoma(229;0.0182)|Lung(427;0.204)		GAGAATCCGTCCATGGGAAAC	0.418		NaN											0	0	0	0.004482	0	8	37									
MTHFR	4524	broad.mit.edu	37	1	11854051	11854051	+	Silent	SNP	G	G	A			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr1:11854051G>A	uc001atc.1	-	9	1627	c.1443C>T	c.(1441-1443)ACC>ACT	p.T481T	MTHFR_uc001atb.1_Silent_p.T504T	NM_005957	NP_005948	P42898	MTHR_HUMAN	5,10-methylenetetrahydrofolate reductase	481					blood circulation|folic acid metabolic process	cytosol	methylenetetrahydrofolate reductase (NADPH) activity|protein binding				0	Ovarian(185;0.249)	Lung NSC(185;8.69e-05)|all_lung(284;9.87e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00826)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;5.66e-06)|COAD - Colon adenocarcinoma(227;0.000261)|BRCA - Breast invasive adenocarcinoma(304;0.000304)|Kidney(185;0.000777)|KIRC - Kidney renal clear cell carcinoma(229;0.00261)|STAD - Stomach adenocarcinoma(313;0.0073)|READ - Rectum adenocarcinoma(331;0.0649)	Benazepril(DB00542)|Cyanocobalamin(DB00115)|Folic Acid(DB00158)|L-Methionine(DB00134)|Menadione(DB00170)|Methotrexate(DB00563)|Pyridoxal Phosphate(DB00114)|Pyridoxine(DB00165)|Raltitrexed(DB00293)|Riboflavin(DB00140)|S-Adenosylmethionine(DB00118)|Tetrahydrofolic acid(DB00116)	GTGAGTTGATGGTGAGGATGC	0.652		NaN											0	0	0	0.007291	0	26	61									
WDTC1	23038	broad.mit.edu	37	1	27623546	27623546	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr1:27623546G>C	uc009vst.2	+	11	1492	c.957G>C	c.(955-957)CAG>CAC	p.Q319H	WDTC1_uc001bno.2_Missense_Mutation_p.Q318H|WDTC1_uc001bnp.1_RNA|WDTC1_uc001bnq.2_5'UTR	NM_015023	NP_055838	Q8N5D0	WDTC1_HUMAN	WD and tetratricopeptide repeats 1	319							protein binding			ovary(1)|central_nervous_system(1)	2		all_cancers(24;3.12e-19)|all_epithelial(13;4.18e-18)|Colorectal(325;0.000147)|all_lung(284;0.000366)|Lung NSC(340;0.000548)|Renal(390;0.00211)|Breast(348;0.00257)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0707)|all_neural(195;0.0966)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0443)|OV - Ovarian serous cystadenocarcinoma(117;1.09e-27)|Colorectal(126;8.83e-09)|COAD - Colon adenocarcinoma(152;1.02e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000544)|KIRC - Kidney renal clear cell carcinoma(1967;0.00201)|STAD - Stomach adenocarcinoma(196;0.00321)|READ - Rectum adenocarcinoma(331;0.0476)		CAGAAGTCCAGAATGGCAAGA	0.463		NaN									OREG0013279	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.001984	0	6	45									
USP24	23358	broad.mit.edu	37	1	55638085	55638085	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr1:55638085G>C	uc001cyg.3	-	3	331	c.331C>G	c.(331-333)CCA>GCA	p.P111A		NM_015306	NP_056121	Q9UPU5	UBP24_HUMAN	ubiquitin specific protease 24	223					ubiquitin-dependent protein catabolic process		binding|cysteine-type peptidase activity|ubiquitin thiolesterase activity			ovary(6)|kidney(6)|breast(1)	13						GTGGGAATTGGATCTTGTTTT	0.358		NaN											0	0	0	0.014758	0	4	13									
C8A	731	broad.mit.edu	37	1	57351743	57351743	+	Silent	SNP	C	C	T			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr1:57351743C>T	uc001cyo.2	+	7	1131	c.999C>T	c.(997-999)TTC>TTT	p.F333F		NM_000562	NP_000553	P07357	CO8A_HUMAN	complement component 8, alpha polypeptide	333	MACPF.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis	extracellular space|membrane attack complex				ovary(1)|central_nervous_system(1)|skin(1)	3						ATGCCAAGTTCATCAATGACT	0.398		NaN											0	0	0	0.014323	0	24	38									
ATXN7L2	127002	broad.mit.edu	37	1	110029160	110029160	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr1:110029160G>A	uc001dxr.2	+	3	241	c.226G>A	c.(226-228)GAT>AAT	p.D76N	ATXN7L2_uc001dxs.2_5'Flank	NM_153340	NP_699171	Q5T6C5	AT7L2_HUMAN	ataxin 7-like 2	76										ovary(2)	2		all_epithelial(167;0.00197)|all_lung(203;0.00291)|Lung NSC(277;0.00453)		Colorectal(144;0.0129)|Lung(183;0.0426)|Epithelial(280;0.0675)|READ - Rectum adenocarcinoma(129;0.0693)|all cancers(265;0.071)|LUSC - Lung squamous cell carcinoma(189;0.228)		CCCTGCCCATGATGACTTCTA	0.542		NaN											0	0	0	0.016723	0	13	24									
ATXN7L2	127002	broad.mit.edu	37	1	110029717	110029717	+	Silent	SNP	G	G	C			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr1:110029717G>C	uc001dxr.2	+	4	402	c.387G>C	c.(385-387)GTG>GTC	p.V129V	ATXN7L2_uc001dxs.2_5'Flank	NM_153340	NP_699171	Q5T6C5	AT7L2_HUMAN	ataxin 7-like 2	129										ovary(2)	2		all_epithelial(167;0.00197)|all_lung(203;0.00291)|Lung NSC(277;0.00453)		Colorectal(144;0.0129)|Lung(183;0.0426)|Epithelial(280;0.0675)|READ - Rectum adenocarcinoma(129;0.0693)|all cancers(265;0.071)|LUSC - Lung squamous cell carcinoma(189;0.228)		GCCATGTAGTGAATGGGCAGG	0.637		NaN											0	0	0	0.00308	0	8	7									
NOTCH2	4853	broad.mit.edu	37	1	120510124	120510124	+	Nonsense_Mutation	SNP	G	G	C			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr1:120510124G>C	uc001eik.2	-	8	1641	c.1385C>G	c.(1384-1386)TCA>TGA	p.S462*	NOTCH2_uc001eil.2_Nonsense_Mutation_p.S462*|NOTCH2_uc001eim.3_Nonsense_Mutation_p.S379*	NM_024408	NP_077719	Q04721	NOTC2_HUMAN	notch 2 preproprotein	462	Extracellular (Potential).|EGF-like 12; calcium-binding (Potential).				anti-apoptosis|bone remodeling|cell cycle arrest|cell fate determination|cell growth|hemopoiesis|induction of apoptosis|negative regulation of cell proliferation|nervous system development|Notch receptor processing|Notch signaling pathway|organ morphogenesis|positive regulation of Ras protein signal transduction|regulation of transcription, DNA-dependent|stem cell maintenance|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|ligand-regulated transcription factor activity|protein binding|receptor activity			lung(8)|haematopoietic_and_lymphoid_tissue(7)|ovary(4)|central_nervous_system(2)|skin(2)|kidney(2)|breast(1)|prostate(1)	27	all_neural(166;0.153)	all_lung(203;1.96e-06)|Lung NSC(69;1.47e-05)|all_epithelial(167;0.000809)		Lung(183;0.0242)|LUSC - Lung squamous cell carcinoma(189;0.133)		GCAGGGGTCTGAATGGCACTC	0.507		NaN	N|F|Mis		marginal zone lymphoma|DLBCL				Alagille_Syndrome				0	0	0	0.016723	0	14	72									
C1orf104	284618	broad.mit.edu	37	1	155290718	155290718	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr1:155290718C>T	uc001fki.2	-	2	839	c.562G>A	c.(562-564)GGG>AGG	p.G188R	RAG1AP1_uc010pey.1_Intron|C1orf104_uc001fkh.1_Intron|RUSC1_uc001fkj.2_5'UTR|RUSC1_uc001fkk.2_5'UTR|RUSC1_uc009wqn.1_5'Flank|RUSC1_uc009wqo.1_5'Flank	NM_001039517	NP_001034606	Q66K80	RUAS1_HUMAN	hypothetical protein LOC284618	188											0	Hepatocellular(266;0.0877)|all_hematologic(923;0.145)		Epithelial(20;1.32e-10)|all cancers(21;3.51e-10)|BRCA - Breast invasive adenocarcinoma(34;0.000549)|LUSC - Lung squamous cell carcinoma(543;0.127)			CTCTGTGCCCCGCCGGGCGGG	0.726		NaN											0	0	0	0.004672	0	3	11									
VSIG8	391123	broad.mit.edu	37	1	159825827	159825827	+	Silent	SNP	G	G	A			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr1:159825827G>A	uc001fuh.2	-	6	953	c.817C>T	c.(817-819)CTG>TTG	p.L273L	C1orf204_uc001fuf.1_5'Flank|C1orf204_uc001fug.1_5'Flank	NM_001013661	NP_001013683	Q5VU13	VSIG8_HUMAN	V-set and immunoglobulin domain containing 8	273	Helical; (Potential).					integral to membrane				central_nervous_system(1)	1	all_hematologic(112;0.0597)					AGCGCGAGCAGAGAGCCCAGG	0.468		NaN											0	0	0	0.006214	0	8	8									
PRG4	10216	broad.mit.edu	37	1	186276451	186276451	+	Missense_Mutation	SNP	A	A	C			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr1:186276451A>C	uc001gru.3	+	7	1651	c.1600A>C	c.(1600-1602)ACC>CCC	p.T534P	PRG4_uc001grt.3_Missense_Mutation_p.T493P|PRG4_uc009wyl.2_Missense_Mutation_p.T441P|PRG4_uc009wym.2_Missense_Mutation_p.T400P|PRG4_uc010poo.1_Intron	NM_005807	NP_005798	Q92954	PRG4_HUMAN	proteoglycan 4 isoform A	534	59 X 8 AA repeats of K-X-P-X-P-T-T-X.|24; approximate.				cell proliferation|immune response	extracellular region	polysaccharide binding|protein binding|scavenger receptor activity			skin(1)	1						ACCCACCACTACCAAGGAGCC	0.632		NaN											0	0	0	0.013537	0	7	51									
CFH	3075	broad.mit.edu	37	1	196697596	196697596	+	Missense_Mutation	SNP	G	G	T			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr1:196697596G>T	uc001gtj.3	+	15	2597	c.2357G>T	c.(2356-2358)GGA>GTA	p.G786V		NM_000186	NP_000177	P08603	CFAH_HUMAN	complement factor H isoform a precursor	786	Sushi 13.				complement activation, alternative pathway	extracellular space				skin(4)|ovary(1)|breast(1)	6						GGAAAAGAAGGATGGATACAC	0.318		NaN											1	0	0.000442599	0.006214	0.000452892	9	25									
CR1L	1379	broad.mit.edu	37	1	207850763	207850763	+	Missense_Mutation	SNP	T	T	A			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr1:207850763T>A	uc001hga.3	+	2	248	c.127T>A	c.(127-129)TTT>ATT	p.F43I	CR1L_uc001hfz.2_RNA|CR1L_uc001hgb.1_RNA	NM_175710	NP_783641	Q2VPA4	CR1L_HUMAN	complement component (3b/4b) receptor 1-like	43	Sushi 1.					cytoplasm|extracellular region|membrane					0						ATGGCTTCCATTTGCCAGGCC	0.413		NaN											0	0	0	0.004482	0	8	61									
KCNH1	3756	broad.mit.edu	37	1	211192470	211192470	+	Silent	SNP	G	G	A			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr1:211192470G>A	uc001hib.2	-	6	857	c.687C>T	c.(685-687)TTC>TTT	p.F229F	KCNH1_uc001hic.2_Silent_p.F229F	NM_172362	NP_758872	O95259	KCNH1_HUMAN	potassium voltage-gated channel, subfamily H,	229	Helical; Name=Segment S1; (Potential).				myoblast fusion|regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	calmodulin binding|delayed rectifier potassium channel activity|two-component sensor activity			ovary(4)|central_nervous_system(1)	5				OV - Ovarian serous cystadenocarcinoma(81;0.0109)|all cancers(67;0.141)|Epithelial(68;0.185)		TGGCTGTATAGAAGGTCAAGA	0.438		NaN											0	0	0	0.006122	0	18	33									
CAPN9	10753	broad.mit.edu	37	1	230903408	230903408	+	Silent	SNP	C	C	T	rs147002278		TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr1:230903408C>T	uc001htz.1	+	5	771	c.658C>T	c.(658-660)CTA>TTA	p.L220L	CAPN9_uc009xfg.1_Silent_p.L157L|CAPN9_uc001hua.1_Silent_p.L220L	NM_006615	NP_006606	O14815	CAN9_HUMAN	calpain 9 isoform 1	220	Calpain catalytic.				digestion|proteolysis	intracellular	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity			ovary(1)	1	Breast(184;0.0871)|Ovarian(103;0.183)	Prostate(94;0.167)				CTATGAGATTCTAGAGAAGGC	0.547		NaN											0	0	0	0.004007	0	15	65									
TUBAL3	79861	broad.mit.edu	37	10	5437320	5437320	+	Silent	SNP	G	G	A	rs144348755		TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr10:5437320G>A	uc001ihy.2	-	3	406	c.366C>T	c.(364-366)ATC>ATT	p.I122I	TUBAL3_uc001ihz.2_Silent_p.I82I	NM_024803	NP_079079	A6NHL2	TBAL3_HUMAN	tubulin, alpha-like 3	122					microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|structural molecule activity			skin(1)	1						GCACAAGGTCGATGACCTCCG	0.622		NaN											0	0	0	0.009718	0	42	67									
NRP1	8829	broad.mit.edu	37	10	33469270	33469270	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr10:33469270C>T	uc001iwx.3	-	17	3029	c.2506G>A	c.(2506-2508)GAA>AAA	p.E836K	NRP1_uc001iwv.3_Missense_Mutation_p.E819K|NRP1_uc009xlz.2_Missense_Mutation_p.E830K|NRP1_uc001iww.3_Missense_Mutation_p.E648K|NRP1_uc001iwy.3_Missense_Mutation_p.E829K	NM_003873	NP_003864	O14786	NRP1_HUMAN	neuropilin 1 isoform a	836	Extracellular (Potential).				axon guidance|cell adhesion|cell-cell signaling|organ morphogenesis|positive regulation of cell proliferation	extracellular region|integral to membrane|plasma membrane	growth factor binding|heparin binding|metal ion binding|vascular endothelial growth factor receptor activity			central_nervous_system(2)|ovary(1)|skin(1)	4					Palifermin(DB00039)|Pegaptanib(DB04895)	CCTTCTCCTTCACCTTCGTAT	0.488		NaN											0	0	0	0.01441	0	50	73									
RBP3	5949	broad.mit.edu	37	10	48388414	48388414	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr10:48388414C>T	uc001jez.2	-	1	2578	c.2464G>A	c.(2464-2466)GAG>AAG	p.E822K		NM_002900	NP_002891	P10745	RET3_HUMAN	retinol-binding protein 3 precursor	822	4 X approximate tandem repeats.|3.				lipid metabolic process|proteolysis|transport|visual perception	interphotoreceptor matrix	retinal binding|serine-type peptidase activity			large_intestine(1)|central_nervous_system(1)	2					Vitamin A(DB00162)	GTCCACACCTCCGTGACTTTT	0.617		NaN											0	0	0	0.014758	0	4	33									
ADAMTS14	140766	broad.mit.edu	37	10	72496495	72496495	+	Silent	SNP	C	C	T			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr10:72496495C>T	uc001jrh.2	+	10	1545	c.1545C>T	c.(1543-1545)TTC>TTT	p.F515F	ADAMTS14_uc001jrg.2_Silent_p.F518F|ADAMTS14_uc001jri.1_Silent_p.F38F	NM_080722	NP_542453	Q8WXS8	ATS14_HUMAN	ADAM metallopeptidase with thrombospondin type 1	515	Disintegrin.				collagen catabolic process|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(5)|upper_aerodigestive_tract(1)	6						ACCCGTACTTCTGCAAGACCA	0.622		NaN											0	0	0	0.016522	0	21	26									
ANKRD1	27063	broad.mit.edu	37	10	92672725	92672725	+	Missense_Mutation	SNP	C	C	A			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr10:92672725C>A	uc001khe.1	-	9	1106	c.858G>T	c.(856-858)AAG>AAT	p.K286N		NM_014391	NP_055206	Q15327	ANKR1_HUMAN	cardiac ankyrin repeat protein	286	ANK 5.				cellular lipid metabolic process|defense response|signal transduction		DNA binding				0		Colorectal(252;0.0475)				CCATCGGCGTCTTCCCAGCCT	0.448		NaN											1	0	7.11191e-15	0.013726	7.72652e-15	34	49									
NFKB2	4791	broad.mit.edu	37	10	104156527	104156527	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr10:104156527G>A	uc001kvb.2	+	5	455	c.190G>A	c.(190-192)GGA>AGA	p.G64R	NFKB2_uc001kva.2_Missense_Mutation_p.G64R|NFKB2_uc010qqk.1_Missense_Mutation_p.G64R|NFKB2_uc001kvd.2_Missense_Mutation_p.G64R|NFKB2_uc009xxc.2_Missense_Mutation_p.G64R	NM_001077494	NP_001070962	Q00653	NFKB2_HUMAN	nuclear factor of kappa light polypeptide gene	64	RHD.				innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	Bcl3/NF-kappaB2 complex|cytosol|nucleoplasm	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			lung(3)	3		Colorectal(252;0.00957)		Epithelial(162;3.4e-08)|all cancers(201;6.41e-07)		CTCCCATGGAGGACTGCCCGG	0.592		NaN	T	IGH@	B-NHL								0	0	0	0.001984	0	6	76									
NAP1L4	4676	broad.mit.edu	37	11	2975819	2975819	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr11:2975819C>T	uc001lxc.2	-	12	1114	c.973G>A	c.(973-975)GAG>AAG	p.E325K	NAP1L4_uc001lxb.2_5'Flank|NAP1L4_uc009ydt.2_RNA|NAP1L4_uc010qxm.1_Missense_Mutation_p.E325K|NAP1L4_uc010qxn.1_Missense_Mutation_p.E325K	NM_005969	NP_005960	Q99733	NP1L4_HUMAN	nucleosome assembly protein 1-like 4	325					nucleosome assembly	chromatin assembly complex|cytoplasm	unfolded protein binding			ovary(1)	1		all_epithelial(84;0.000236)|Medulloblastoma(188;0.00106)|Breast(177;0.00328)|Ovarian(85;0.00556)|all_neural(188;0.00681)		BRCA - Breast invasive adenocarcinoma(625;0.00301)|LUSC - Lung squamous cell carcinoma(625;0.211)		ACTATCCGCTCACGGAAAAAG	0.483		NaN											0	0	0	0.010729	0	11	30									
C11orf40	143501	broad.mit.edu	37	11	4593489	4593489	+	Missense_Mutation	SNP	G	G	C	rs141444146		TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr11:4593489G>C	uc010qyg.1	-	3	344	c.344C>G	c.(343-345)TCT>TGT	p.S115C		NM_144663	NP_653264	Q8WZ69	CK040_HUMAN	hypothetical protein LOC143501	115										ovary(2)	2		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;4.28e-12)|BRCA - Breast invasive adenocarcinoma(625;0.0288)|LUSC - Lung squamous cell carcinoma(625;0.192)		CCAGGAAATAGAGATTCCACT	0.458		NaN											0	0	0	0.013537	0	11	27									
FOLH1	2346	broad.mit.edu	37	11	49175904	49175904	+	Silent	SNP	G	G	T			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr11:49175904G>T	uc001ngy.2	-	16	2025	c.1764C>A	c.(1762-1764)GCC>GCA	p.A588A	FOLH1_uc001ngx.2_Silent_p.A20A|FOLH1_uc001ngz.2_Silent_p.A588A|FOLH1_uc009yly.2_Silent_p.A573A|FOLH1_uc009ylz.2_Silent_p.A573A|FOLH1_uc009yma.2_Silent_p.A280A	NM_004476	NP_004467	Q04609	FOLH1_HUMAN	folate hydrolase 1 isoform 1	588	Extracellular (Probable).				proteolysis	cytoplasm|integral to plasma membrane|membrane fraction|nucleus	carboxypeptidase activity|dipeptidase activity|metal ion binding|metallopeptidase activity			large_intestine(1)|ovary(1)|skin(1)	3					Capromab(DB00089)|L-Glutamic Acid(DB00142)	CTATGGAATTGGCTAGCTCAA	0.383		NaN											1	0	2.27111e-07	0.013537	2.40792e-07	7	42									
OR5D18	219438	broad.mit.edu	37	11	55587651	55587651	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr11:55587651C>G	uc010rin.1	+	1	546	c.546C>G	c.(544-546)TTC>TTG	p.F182L		NM_001001952	NP_001001952	Q8NGL1	OR5DI_HUMAN	olfactory receptor, family 5, subfamily D,	182	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)	3		all_epithelial(135;0.208)				TCTGTGAGTTCTCCTCACTAC	0.428		NaN											0	0	0	0.008361	0	29	76									
TNKS1BP1	85456	broad.mit.edu	37	11	57080172	57080172	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr11:57080172C>G	uc001njr.2	-	4	2302	c.1990G>C	c.(1990-1992)GAG>CAG	p.E664Q	TNKS1BP1_uc001njs.2_Missense_Mutation_p.E664Q|TNKS1BP1_uc009ymd.1_Missense_Mutation_p.E115Q	NM_033396	NP_203754	Q9C0C2	TB182_HUMAN	tankyrase 1-binding protein 1	664	Pro-rich.|Acidic.				nuclear-transcribed mRNA poly(A) tail shortening|telomere maintenance via telomerase	cytoskeleton|cytosol|nuclear telomeric heterochromatin	ankyrin binding|enzyme binding			skin(1)	1		all_epithelial(135;0.21)				TCTTGAGCCTCTGTCCTGGCT	0.642		NaN											0	0	0	0.016723	0	13	29									
UBE2L6	9246	broad.mit.edu	37	11	57327878	57327878	+	Missense_Mutation	SNP	G	G	T			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr11:57327878G>T	uc001nkn.1	-	2	151	c.55C>A	c.(55-57)CCC>ACC	p.P19T	UBE2L6_uc001nko.1_5'UTR	NM_004223	NP_004214	O14933	UB2L6_HUMAN	ubiquitin-conjugating enzyme E2L 6 isoform 1	19					negative regulation of type I interferon production	cytosol	protein binding|ubiquitin-protein ligase activity			ovary(1)	1						AGGTATGGGGGAGGCTTCTTC	0.592		NaN											1	0	1.3612e-06	0.003163	1.42602e-06	16	64									
STIP1	10963	broad.mit.edu	37	11	63970354	63970354	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr11:63970354G>A	uc001nyk.1	+	11	1399	c.1252G>A	c.(1252-1254)GAG>AAG	p.E418K	STIP1_uc010rnb.1_Missense_Mutation_p.E394K	NM_006819	NP_006810	P31948	STIP1_HUMAN	stress-induced-phosphoprotein 1	418	TPR 8.				axon guidance|response to stress	Golgi apparatus|nucleus				ovary(2)|liver(1)	3						CTAGGACTGTGAGGAATGTAT	0.483		NaN											0	0	0	0.01892	0	23	68									
PLCB3	5331	broad.mit.edu	37	11	64022383	64022383	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr11:64022383G>A	uc001nzb.2	+	4	260	c.260G>A	c.(259-261)CGG>CAG	p.R87Q	PLCB3_uc009ypg.1_Missense_Mutation_p.R87Q|PLCB3_uc009yph.1_Intron|PLCB3_uc009ypi.2_Missense_Mutation_p.R87Q	NM_000932	NP_000923	Q01970	PLCB3_HUMAN	phospholipase C beta 3	87					intracellular signal transduction|lipid catabolic process|synaptic transmission	cytosol	calcium ion binding|calmodulin binding|phosphatidylinositol phospholipase C activity|signal transducer activity			ovary(1)|pancreas(1)	2						CCCAAGATCCGGGAAGTTCTG	0.607		NaN											0	0	0	0.004672	0	3	29									
AIP	9049	broad.mit.edu	37	11	67257650	67257650	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr11:67257650G>A	uc001olv.2	+	4	735	c.610G>A	c.(610-612)GAT>AAT	p.D204N		NM_003977	NP_003968	O00170	AIP_HUMAN	aryl hydrocarbon receptor interacting protein	204	TPR 1.				protein maturation by protein folding|protein targeting to mitochondrion	nucleus	signal transducer activity|transcription coactivator activity|transcription factor binding|unfolded protein binding				0						CAAGTACTACGATGCCATTGC	0.607		NaN							Familial_Isolated_Pituitary_Adenoma_				0	0	0	0.013537	0	10	23									
SHANK2	22941	broad.mit.edu	37	11	70319408	70319408	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr11:70319408G>A	uc001oqc.2	-	22	5194	c.5116C>T	c.(5116-5118)CGT>TGT	p.R1706C	SHANK2_uc010rqn.1_Missense_Mutation_p.R1118C|SHANK2_uc001opz.2_Missense_Mutation_p.R1111C|uc009ysn.1_Intron|SHANK2_uc001opy.2_Missense_Mutation_p.R42C	NM_012309	NP_036441	Q9UPX8	SHAN2_HUMAN	SH3 and multiple ankyrin repeat domains 2	1327					intracellular signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	GKAP/Homer scaffold activity|ionotropic glutamate receptor binding|SH3 domain binding			ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	5			LUSC - Lung squamous cell carcinoma(11;4.72e-09)|STAD - Stomach adenocarcinoma(18;0.071)			CTTGGGGCACGTCTTGTTCCT	0.642		NaN											0	0	0	0.014758	0	5	46									
MOGAT2	80168	broad.mit.edu	37	11	75442218	75442218	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr11:75442218G>A	uc010rru.1	+	6	892	c.892G>A	c.(892-894)GAG>AAG	p.E298K	MOGAT2_uc010rrv.1_Missense_Mutation_p.E216K	NM_025098	NP_079374	Q3SYC2	MOGT2_HUMAN	monoacylglycerol O-acyltransferase 2	298					glycerol metabolic process	endoplasmic reticulum membrane|integral to membrane	2-acylglycerol O-acyltransferase activity			ovary(2)	2	Ovarian(111;0.103)					GCATCCCTCGGAGGAGGAGGT	0.567		NaN											0	0	0	0.00499	0	18	39									
PANX1	24145	broad.mit.edu	37	11	93911662	93911662	+	Missense_Mutation	SNP	A	A	G			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr11:93911662A>G	uc001per.2	+	3	834	c.449A>G	c.(448-450)TAC>TGC	p.Y150C	PANX1_uc001peq.2_Missense_Mutation_p.Y150C	NM_015368	NP_056183	Q96RD7	PANX1_HUMAN	pannexin 1	150	Cytoplasmic (Potential).				positive regulation of interleukin-1 beta secretion|protein hexamerization|synaptic transmission	bleb|endoplasmic reticulum membrane|gap junction|integral to membrane	calcium channel activity|gap junction hemi-channel activity|leak channel activity|receptor binding				0		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)				GACAAAGTTTACAACCGTGCA	0.498		NaN											0	0	0	0.013537	0	13	47									
PHLDB1	23187	broad.mit.edu	37	11	118516477	118516477	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr11:118516477G>C	uc001ptr.1	+	18	3794	c.3441G>C	c.(3439-3441)AAG>AAC	p.K1147N	PHLDB1_uc001pts.2_Missense_Mutation_p.K1147N|PHLDB1_uc001ptt.2_Missense_Mutation_p.K1100N|PHLDB1_uc001ptu.1_RNA|PHLDB1_uc001ptv.1_Missense_Mutation_p.K962N|PHLDB1_uc001ptw.1_Missense_Mutation_p.K502N|PHLDB1_uc009zai.1_Missense_Mutation_p.K183N|PHLDB1_uc001ptx.1_Missense_Mutation_p.K183N|PHLDB1_uc010ryi.1_3'UTR	NM_015157	NP_055972	Q86UU1	PHLB1_HUMAN	pleckstrin homology-like domain, family B,	1147	Potential.										0	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0523)|all_hematologic(192;0.0735)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;3.4e-05)		ACATGGGGAAGATCGAGGAGA	0.612		NaN											0	0	0	0.012319	0	21	46									
PANX3	116337	broad.mit.edu	37	11	124482880	124482880	+	Silent	SNP	T	T	C			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr11:124482880T>C	uc001qah.2	+	2	186	c.186T>C	c.(184-186)TCT>TCC	p.S62S		NM_052959	NP_443191	Q96QZ0	PANX3_HUMAN	pannexin 3	62	Extracellular (Potential).				protein hexamerization	gap junction|integral to membrane	gap junction hemi-channel activity|ion channel activity				0	all_hematologic(175;0.215)	Breast(109;0.00109)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0219)		TTGCAGGGTCTCCGATCAGCT	0.572		NaN											0	0	0	0.003163	0	15	41									
CHD4	1108	broad.mit.edu	37	12	6691413	6691413	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr12:6691413C>G	uc001qpo.2	-	30	4569	c.4405G>C	c.(4405-4407)GAG>CAG	p.E1469Q	CHD4_uc001qpn.2_Missense_Mutation_p.E1462Q|CHD4_uc001qpp.2_Missense_Mutation_p.E1494Q|uc001qpq.1_Intron|SCARNA11_uc001qpr.1_5'Flank	NM_001273	NP_001264	Q14839	CHD4_HUMAN	chromodomain helicase DNA binding protein 4	1469					chromatin modification|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	microtubule organizing center|NuRD complex	ATP binding|ATP-dependent DNA helicase activity|DNA binding|zinc ion binding			central_nervous_system(2)	2						GCCCCCGGCTCACATAAATGC	0.473		NaN											0	0	0	0.008291	0	10	54									
PDE6H	5149	broad.mit.edu	37	12	15131027	15131027	+	Missense_Mutation	SNP	G	G	T			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr12:15131027G>T	uc001rcr.2	+	2	165	c.81G>T	c.(79-81)AAG>AAT	p.K27N		NM_006205	NP_006196	Q13956	CNCG_HUMAN	phosphodiesterase 6H	27	Arg/Lys-rich (basic).				visual perception		3',5'-cyclic-GMP phosphodiesterase activity|cGMP binding|enzyme inhibitor activity			ovary(1)|skin(1)	2						CCAAGTTCAAGCAGAGGCAGA	0.483		NaN											1	0	2.0095e-06	0.001984	2.09687e-06	7	21									
SLCO1B1	10599	broad.mit.edu	37	12	21391927	21391927	+	Missense_Mutation	SNP	G	G	T			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr12:21391927G>T	uc001req.3	+	15	1984	c.1880G>T	c.(1879-1881)GGC>GTC	p.G627V		NM_006446	NP_006437	Q9Y6L6	SO1B1_HUMAN	solute carrier organic anion transporter family,	627	Extracellular (Potential).				bile acid metabolic process|sodium-independent organic anion transport	basolateral plasma membrane|integral to plasma membrane|membrane fraction	bile acid transmembrane transporter activity|sodium-independent organic anion transmembrane transporter activity|thyroid hormone transmembrane transporter activity			ovary(3)|skin(3)|pancreas(1)|central_nervous_system(1)	8					Digoxin(DB00390)|Gemfibrozil(DB01241)|Pravastatin(DB00175)	GTCTACTTGGGCTTGTCTTCA	0.279		NaN											1	0	0.00307968	0.00308	0.00312706	8	31									
CASC1	55259	broad.mit.edu	37	12	25302597	25302597	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr12:25302597G>C	uc001rgl.2	-	6	614	c.532C>G	c.(532-534)CTT>GTT	p.L178V	CASC1_uc001rgk.2_Missense_Mutation_p.L184V|CASC1_uc001rgm.3_Missense_Mutation_p.L242V|CASC1_uc001rgj.2_Missense_Mutation_p.L138V|CASC1_uc010sje.1_Missense_Mutation_p.L119V|CASC1_uc010sjf.1_Missense_Mutation_p.L66V|CASC1_uc010sjg.1_Missense_Mutation_p.L178V	NM_001082973	NP_001076442	Q6TDU7	CASC1_HUMAN	cancer susceptibility candidate 1 isoform b	178										ovary(2)	2	Acute lymphoblastic leukemia(6;0.00112)|all_hematologic(7;0.00152)|Melanoma(3;0.0301)|Colorectal(261;0.11)		OV - Ovarian serous cystadenocarcinoma(3;7.42e-20)|Epithelial(3;7.58e-16)|all cancers(3;1.07e-13)			CCGAATTTAAGATGAAGGAGC	0.284		NaN											0	0	0	0.008291	0	10	34									
KITLG	4254	broad.mit.edu	37	12	88900821	88900821	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr12:88900821C>G	uc001tav.2	-	7	881	c.698G>C	c.(697-699)GGA>GCA	p.G233A	KITLG_uc009zsn.2_Intron|KITLG_uc001taw.2_Missense_Mutation_p.G205A|KITLG_uc009zso.1_RNA	NM_000899	NP_000890	P21583	SCF_HUMAN	KIT ligand isoform b precursor	233	Helical; (Potential).				cell adhesion|cell proliferation|hemopoiesis|male gonad development|positive regulation of DNA replication|signal transduction	cytoplasm|cytoskeleton|integral to membrane|plasma membrane	growth factor activity|identical protein binding|stem cell factor receptor binding			ovary(1)	1						GTATAAGGCTCCAAAAGCAAA	0.378		NaN							Testicular_Cancer_Familial_Clustering_of				0	0	0	0.001168	0	5	40									
ANO4	121601	broad.mit.edu	37	12	101510519	101510519	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr12:101510519G>C	uc010svm.1	+	25	3085	c.2513G>C	c.(2512-2514)CGA>CCA	p.R838P	ANO4_uc001thw.2_Missense_Mutation_p.R803P|ANO4_uc001thx.2_Missense_Mutation_p.R838P|ANO4_uc001thy.2_Missense_Mutation_p.R358P	NM_178826	NP_849148	Q32M45	ANO4_HUMAN	anoctamin 4	838	Cytoplasmic (Potential).					chloride channel complex	chloride channel activity			ovary(4)|skin(2)	6						TTTGAGAACCGATCTGAGCCT	0.507		NaN								HNSCC(74;0.22)			0	0	0	0.007291	0	29	87									
MYBPC1	4604	broad.mit.edu	37	12	102060550	102060550	+	Silent	SNP	T	T	C			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr12:102060550T>C	uc001tii.2	+	21	2412	c.2310T>C	c.(2308-2310)AAT>AAC	p.N770N	MYBPC1_uc001tig.2_Intron|MYBPC1_uc010svq.1_Intron|MYBPC1_uc001tih.2_Intron|MYBPC1_uc001tij.2_Intron|MYBPC1_uc010svr.1_Intron|MYBPC1_uc010svs.1_Silent_p.N770N|MYBPC1_uc010svt.1_Intron|MYBPC1_uc010svu.1_Intron|MYBPC1_uc001tik.2_Intron|MYBPC1_uc001til.2_5'UTR|MYBPC1_uc001tim.2_5'UTR	NM_206820	NP_996556	Q00872	MYPC1_HUMAN	myosin binding protein C, slow type isoform 3	770	Fibronectin type-III 2.				cell adhesion|muscle filament sliding	cytosol|myofibril|myosin filament	actin binding|structural constituent of muscle|titin binding			ovary(2)|liver(1)|skin(1)	4						CTGATGAAAATGGGGAGGCTG	0.368		NaN											0	0	0	0.013537	0	12	59									
ANAPC7	51434	broad.mit.edu	37	12	110825668	110825668	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr12:110825668C>G	uc001tqo.2	-	5	653	c.652G>C	c.(652-654)GAG>CAG	p.E218Q	ANAPC7_uc001tqp.3_Missense_Mutation_p.E218Q	NM_016238	NP_057322	Q9UJX3	APC7_HUMAN	anaphase-promoting complex subunit 7 isoform a	218					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination	anaphase-promoting complex|cytosol|nucleoplasm	protein phosphatase binding				0						GATGCCACCTCTGCCCCTTTT	0.473		NaN											0	0	0	0.006214	0	9	14									
DNAH10	196385	broad.mit.edu	37	12	124345622	124345622	+	Silent	SNP	C	C	T			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr12:124345622C>T	uc001uft.3	+	38	6484	c.6459C>T	c.(6457-6459)TAC>TAT	p.Y2153Y		NM_207437	NP_997320	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	2153	AAA 2 (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(3)|skin(2)|central_nervous_system(1)	6	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		TAGAACTCTACGGCATCCTGG	0.493		NaN											0	0	0	0.010729	0	11	46									
FREM2	341640	broad.mit.edu	37	13	39263186	39263186	+	Missense_Mutation	SNP	C	C	A			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr13:39263186C>A	uc001uwv.2	+	1	2014	c.1705C>A	c.(1705-1707)CTG>ATG	p.L569M		NM_207361	NP_997244	Q5SZK8	FREM2_HUMAN	FRAS1-related extracellular matrix protein 2	569	CSPG 3.|Extracellular (Potential).				cell communication|homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(7)|pancreas(1)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|skin(1)	11		Lung NSC(96;1.04e-07)|Prostate(109;0.00384)|Breast(139;0.00396)|Lung SC(185;0.0565)|Hepatocellular(188;0.114)		all cancers(112;3.32e-07)|Epithelial(112;1.66e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00154)|BRCA - Breast invasive adenocarcinoma(63;0.00631)|GBM - Glioblastoma multiforme(144;0.0312)		CAACACGGGGCTGACACTGGC	0.547		NaN											1	0	3.09899e-07	0.004482	3.27253e-07	9	24									
HAUS4	54930	broad.mit.edu	37	14	23419580	23419580	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr14:23419580C>G	uc001whp.2	-	5	536	c.505G>C	c.(505-507)GAG>CAG	p.E169Q	HAUS4_uc001who.2_RNA|HAUS4_uc001whq.2_Intron|HAUS4_uc001whr.2_Missense_Mutation_p.E169Q|HAUS4_uc001whs.2_Missense_Mutation_p.E124Q|HAUS4_uc001wht.2_Missense_Mutation_p.E169Q|HAUS4_uc001whu.2_Missense_Mutation_p.E124Q|HAUS4_uc001whv.2_Missense_Mutation_p.E45Q|HAUS4_uc001whw.2_Missense_Mutation_p.E169Q|HAUS4_uc001whx.2_Missense_Mutation_p.E124Q	NM_017815	NP_060285	Q9H6D7	HAUS4_HUMAN	HAUS augmin-like complex, subunit 4	169					cell division|centrosome organization|mitosis|spindle assembly	centrosome|HAUS complex|microtubule|spindle				ovary(1)	1						AGCTGCTCCTCTACTTCTTGC	0.358		NaN											0	0	0	0.00308	0	8	26									
KIAA0391	9692	broad.mit.edu	37	14	35592881	35592881	+	Missense_Mutation	SNP	A	A	G			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr14:35592881A>G	uc001wsy.1	+	2	790	c.430A>G	c.(430-432)ATC>GTC	p.I144V	KIAA0391_uc010tps.1_Missense_Mutation_p.I49V|KIAA0391_uc001wsz.1_Missense_Mutation_p.I144V|KIAA0391_uc001wta.2_RNA|KIAA0391_uc001wtb.1_Missense_Mutation_p.I144V|KIAA0391_uc001wtc.1_Intron|PPP2R3C_uc001wss.2_5'Flank|PPP2R3C_uc001wst.2_5'Flank|PPP2R3C_uc010tpr.1_5'Flank|PPP2R3C_uc001wsu.2_5'Flank|PPP2R3C_uc010amn.1_5'Flank|PPP2R3C_uc001wsw.2_5'Flank|PPP2R3C_uc001wsx.1_5'Flank	NM_014672	NP_055487	O15091	MRRP3_HUMAN	mitochondrial RNase P protein 3 precursor	144					tRNA processing	mitochondrion					0	Breast(36;0.0545)|Hepatocellular(127;0.158)|Prostate(35;0.184)		Lung(238;2.93e-05)|LUAD - Lung adenocarcinoma(48;3.86e-05)|Epithelial(34;0.0114)|all cancers(34;0.0277)	GBM - Glioblastoma multiforme(112;0.0593)		CGAAAGTTGGATCATTTCACA	0.398		NaN											0	0	0	0.004482	0	9	64									
SYNE2	23224	broad.mit.edu	37	14	64625483	64625483	+	Silent	SNP	G	G	A			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr14:64625483G>A	uc001xgm.2	+	86	16163	c.15933G>A	c.(15931-15933)GAG>GAA	p.E5311E	SYNE2_uc001xgl.2_Silent_p.E5311E|SYNE2_uc010apy.2_Silent_p.E1696E|SYNE2_uc001xgn.2_Silent_p.E273E|SYNE2_uc001xgo.2_RNA|SYNE2_uc001xgp.2_Silent_p.E40E	NM_015180	NP_055995	Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	5311	Potential.|Cytoplasmic (Potential).				centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			ovary(8)|breast(4)|central_nervous_system(1)|pancreas(1)	14				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		TATCATTGGAGACCTTGAGAT	0.433		NaN											0	0	0	0.016723	0	12	25									
STON2	85439	broad.mit.edu	37	14	81744349	81744349	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr14:81744349C>T	uc010tvu.1	-	4	1507	c.1306G>A	c.(1306-1308)GAG>AAG	p.E436K	STON2_uc001xvk.1_Missense_Mutation_p.E436K|STON2_uc010tvt.1_Missense_Mutation_p.E233K	NM_033104	NP_149095	Q8WXE9	STON2_HUMAN	stonin 2	436	SHD.				endocytosis|intracellular protein transport|regulation of endocytosis	clathrin adaptor complex|nucleolus	protein binding			skin(3)|pancreas(2)	5				BRCA - Breast invasive adenocarcinoma(234;0.0348)		TTTTTCTTCTCAGGGATCCTC	0.527		NaN											0	0	0	0.01441	0	50	110									
TECPR2	9895	broad.mit.edu	37	14	102898165	102898165	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr14:102898165G>C	uc001ylw.1	+	8	1265	c.1117G>C	c.(1117-1119)GAG>CAG	p.E373Q	TECPR2_uc010awl.2_Missense_Mutation_p.E373Q|TECPR2_uc010txx.1_Intron	NM_014844	NP_055659	O15040	TCPR2_HUMAN	tectonin beta-propeller repeat containing 2	373							protein binding			lung(1)|central_nervous_system(1)|skin(1)	3						TGGATGCTCAGAGCGTGTCCA	0.557		NaN											0	0	0	0.01892	0	25	70									
XRCC3	7517	broad.mit.edu	37	14	104177481	104177481	+	Translation_Start_Site	SNP	G	G	C			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr14:104177481G>C	uc001yny.3	-	4	324	c.-56C>G	c.(-58--54)ATCCA>ATGCA		XRCC3_uc001ynx.3_Translation_Start_Site|XRCC3_uc001ynz.3_Translation_Start_Site|XRCC3_uc001yoa.3_Translation_Start_Site|XRCC3_uc001yob.1_RNA	NM_005432	NP_005423	O43542	XRCC3_HUMAN	X-ray repair cross complementing protein 3						DNA recombination|DNA repair	mitochondrion|nucleus|perinuclear region of cytoplasm	ATP binding|DNA binding|DNA-dependent ATPase activity				0		Melanoma(154;0.155)|all_epithelial(191;0.19)		Epithelial(152;0.239)		CAGAACAATGGATGCAAATTC	0.527		NaN						Direct_reversal_of_damage|Homologous_recombination					0	0	0	0.014758	0	5	9									
FMN1	342184	broad.mit.edu	37	15	33192230	33192230	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr15:33192230C>T	uc001zhf.3	-	10	2935	c.2935G>A	c.(2935-2937)GAT>AAT	p.D979N		NM_001103184	NP_001096654	Q68DA7	FMN1_HUMAN	formin 1	1202	FH2.				actin cytoskeleton organization	actin cytoskeleton|adherens junction|cytoplasm|nucleus	actin binding			ovary(1)	1		all_lung(180;1.14e-07)		all cancers(64;3.05e-15)|Epithelial(43;1.67e-10)|GBM - Glioblastoma multiforme(186;4.95e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0262)		CTATATCCATCGGCTTGTCCC	0.393		NaN											0	0	0	0.009718	0	42	112									
EIF2AK4	440275	broad.mit.edu	37	15	40235658	40235658	+	Missense_Mutation	SNP	A	A	G			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr15:40235658A>G	uc001zkm.1	+	3	382	c.332A>G	c.(331-333)GAA>GGA	p.E111G	EIF2AK4_uc001zkl.2_Missense_Mutation_p.E111G	NM_001013703	NP_001013725	Q9P2K8	E2AK4_HUMAN	eukaryotic translation initiation factor 2 alpha	111	RWD.				translation	cytosolic ribosome	aminoacyl-tRNA ligase activity|ATP binding|eukaryotic translation initiation factor 2alpha kinase activity|protein homodimerization activity			lung(2)|stomach(1)|skin(1)	4		all_cancers(109;1.05e-19)|all_epithelial(112;4.38e-17)|Lung NSC(122;1.09e-12)|all_lung(180;3.56e-11)|Melanoma(134;0.0575)|Ovarian(310;0.0826)|Colorectal(260;0.119)		GBM - Glioblastoma multiforme(113;5.31e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0616)		TCTCGCCTAGAAGAACTGGCC	0.338		NaN											0	0	0	0.004007	0	15	42									
BMF	90427	broad.mit.edu	37	15	40396430	40396430	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr15:40396430C>T	uc001zkv.2	-	3	490	c.404G>A	c.(403-405)CGA>CAA	p.R135Q	BMF_uc001zkt.2_Intron|BMF_uc001zku.2_Intron|BMF_uc001zkw.2_Missense_Mutation_p.R135Q	NM_033503	NP_277038	Q96LC9	BMF_HUMAN	Bcl2 modifying factor isoform bmf-1	135	BH3.				activation of pro-apoptotic gene products|induction of apoptosis by intracellular signals|positive regulation of protein homooligomerization|positive regulation of release of cytochrome c from mitochondria	cytosol|mitochondrial outer membrane|myosin complex|plasma membrane	protein binding			ovary(1)	1		all_cancers(109;4.18e-18)|all_epithelial(112;6.15e-15)|Lung NSC(122;5.63e-11)|all_lung(180;1.4e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;1.29e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0516)		CTGAAGCTTTCGGGCAATCTG	0.597		NaN											0	0	0	0.005443	0	28	93									
MGA	23269	broad.mit.edu	37	15	42042440	42042440	+	Nonsense_Mutation	SNP	C	C	G			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr15:42042440C>G	uc010ucy.1	+	17	6816	c.6635C>G	c.(6634-6636)TCA>TGA	p.S2212*	MGA_uc010ucz.1_Nonsense_Mutation_p.S2003*|MGA_uc010uda.1_Nonsense_Mutation_p.S828*|MGA_uc001zoi.2_Nonsense_Mutation_p.S426*	NM_001164273	NP_001157745	Q8IWI9	MGAP_HUMAN	MAX-interacting protein isoform 1	2173	Basic motif.					MLL1 complex	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(6)|kidney(3)|upper_aerodigestive_tract(1)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	12		all_cancers(109;0.00356)|all_epithelial(112;0.0413)|all_lung(180;0.18)|Ovarian(310;0.238)		OV - Ovarian serous cystadenocarcinoma(18;1.41e-18)|GBM - Glioblastoma multiforme(113;2.15e-06)|COAD - Colon adenocarcinoma(120;0.031)|Lung(196;0.0721)|BRCA - Breast invasive adenocarcinoma(123;0.0964)|Colorectal(105;0.0998)|LUSC - Lung squamous cell carcinoma(244;0.235)		CAGGAAAATTCAGATGTGTTT	0.398		NaN											0	0	0	0.013726	0	31	66									
STRC	161497	broad.mit.edu	37	15	43896298	43896298	+	Nonsense_Mutation	SNP	C	C	T			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr15:43896298C>T	uc001zsf.2	-	22	4349	c.4271G>A	c.(4270-4272)TGG>TAG	p.W1424*	STRC_uc010bdl.2_Nonsense_Mutation_p.W651*|STRC_uc001zse.2_5'UTR	NM_153700	NP_714544	Q7RTU9	STRC_HUMAN	stereocilin precursor	1424					sensory perception of sound	cell surface					0		all_cancers(109;3.26e-15)|all_epithelial(112;1.48e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.027)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.56e-07)		GCTCTGCTCCCAGCTCTGCTG	0.582		NaN											0	0	0	0.008291	0	8	27									
DUOX2	50506	broad.mit.edu	37	15	45396470	45396470	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr15:45396470C>T	uc010bea.2	-	19	2631	c.2428G>A	c.(2428-2430)GAG>AAG	p.E810K	DUOX2_uc001zun.2_Missense_Mutation_p.E810K	NM_014080	NP_054799	Q9NRD8	DUOX2_HUMAN	dual oxidase 2 precursor	810	Cytoplasmic (Potential).				cuticle development|cytokine-mediated signaling pathway|hormone biosynthetic process|hydrogen peroxide catabolic process|response to cAMP|response to virus	apical plasma membrane|integral to membrane	calcium ion binding|electron carrier activity|flavin adenine dinucleotide binding|heme binding|NAD(P)H oxidase activity|peroxidase activity			ovary(2)|skin(2)|pancreas(1)	5		all_cancers(109;3.79e-11)|all_epithelial(112;2.92e-09)|Lung NSC(122;3.55e-06)|all_lung(180;2.56e-05)|Melanoma(134;0.027)		all cancers(107;1.05e-18)|GBM - Glioblastoma multiforme(94;4.23e-07)|COAD - Colon adenocarcinoma(120;0.0668)|Colorectal(133;0.068)		TCGGCAAACTCGGCCCTGCTC	0.627		NaN											0	0	0	0.016723	0	12	14									
TMC3	342125	broad.mit.edu	37	15	81625286	81625286	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr15:81625286C>T	uc002bgo.1	-	22	2777	c.2777G>A	c.(2776-2778)CGA>CAA	p.R926Q	TMC3_uc010blr.1_RNA	NM_001080532	NP_001074001	Q7Z5M5	TMC3_HUMAN	transmembrane channel-like 3	926	Cytoplasmic (Potential).					integral to membrane				ovary(1)|liver(1)	2						TGCATATTGTCGCACGTTCCT	0.512		NaN											0	0	0	0.006122	0	17	36									
WDR90	197335	broad.mit.edu	37	16	708543	708543	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr16:708543G>A	uc002cii.1	+	23	2839	c.2785G>A	c.(2785-2787)GAG>AAG	p.E929K	WDR90_uc002cij.1_Intron|WDR90_uc002cik.1_Missense_Mutation_p.E456K|WDR90_uc002cil.1_RNA|WDR90_uc002cim.1_Missense_Mutation_p.E103K|WDR90_uc002cin.1_5'Flank	NM_145294	NP_660337	Q96KV7	WDR90_HUMAN	WD repeat domain 90	929	WD 10.									ovary(1)	1		Hepatocellular(780;0.0218)				TGTCCACCCTGAGCCCTGCCC	0.662		NaN											0	0	0	0.009535	0	29	67									
RBBP6	5930	broad.mit.edu	37	16	24578570	24578570	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr16:24578570C>T	uc002dmh.2	+	15	2736	c.1696C>T	c.(1696-1698)CCG>TCG	p.P566S	RBBP6_uc010vcb.1_Missense_Mutation_p.P433S|RBBP6_uc002dmi.2_Missense_Mutation_p.P566S|RBBP6_uc010bxr.2_Intron|RBBP6_uc002dmk.2_Missense_Mutation_p.P433S	NM_006910	NP_008841	Q7Z6E9	RBBP6_HUMAN	retinoblastoma-binding protein 6 isoform 1	566					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	chromosome|nucleolus|ubiquitin ligase complex	nucleic acid binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(3)|pancreas(1)	4				GBM - Glioblastoma multiforme(48;0.0518)		tcctttgtatccgcctcctcc	0.299		NaN											0	0	0	0.008871	0	21	84									
NSMCE1	197370	broad.mit.edu	37	16	27246536	27246536	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr16:27246536C>T	uc002doi.1	-	3	319	c.221G>A	c.(220-222)GGA>GAA	p.G74E	NSMCE1_uc002doj.1_RNA	NM_145080	NP_659547	Q8WV22	NSE1_HUMAN	non-SMC element 1 homolog	74					DNA recombination|DNA repair|intracellular signal transduction	nucleus	zinc ion binding				0						TTCCGTGACTCCTCTCTTTAT	0.493		NaN									OREG0023693	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.008291	0	10	34									
TAOK2	9344	broad.mit.edu	37	16	29998793	29998793	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr16:29998793G>A	uc002dva.1	+	16	3983	c.3200G>A	c.(3199-3201)GGC>GAC	p.G1067D	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|TAOK2_uc002dvb.1_Intron|TAOK2_uc002dvc.1_Intron|TAOK2_uc010bzm.1_Missense_Mutation_p.G1074D|TAOK2_uc002dvd.1_Missense_Mutation_p.G894D	NM_016151	NP_057235	Q9UL54	TAOK2_HUMAN	TAO kinase 2 isoform 2	1067					actin cytoskeleton organization|activation of MAPKK activity|apoptosis|cell migration|focal adhesion assembly|positive regulation of JNK cascade|protein targeting to membrane|regulation of cell growth|regulation of cell shape|response to stress	cytoplasmic vesicle membrane|cytoskeleton|dendrite|integral to membrane|nucleolus	ATP binding|protein serine/threonine kinase activity			ovary(1)	1						GCAGCGGGGGGCAGATGGGTG	0.692		NaN											0	0	0	0.00308	0	6	31									
HSD3B7	80270	broad.mit.edu	37	16	30997087	30997087	+	Silent	SNP	C	C	T			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr16:30997087C>T	uc002eaf.2	+	2	214	c.108C>T	c.(106-108)CTC>CTT	p.L36L	HSD3B7_uc010cac.2_Silent_p.L36L|HSD3B7_uc002eag.2_Silent_p.L36L|HSD3B7_uc002eah.2_Silent_p.L36L	NM_025193	NP_079469	Q9H2F3	3BHS7_HUMAN	hydroxy-delta-5-steroid dehydrogenase, 3 beta-	36					bile acid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	3-beta-hydroxy-delta5-steroid dehydrogenase activity|binding|cholest-5-ene-3-beta,7-alpha-diol 3-beta-dehydrogenase activity				0						AGCCCCGGCTCGGGGAGCTGC	0.642		NaN											0	0	0	0.014758	0	5	6									
SLC12A3	6559	broad.mit.edu	37	16	56901090	56901090	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr16:56901090G>A	uc010ccm.2	+	2	420	c.391G>A	c.(391-393)GAG>AAG	p.E131K	SLC12A3_uc002ekd.3_Missense_Mutation_p.E131K|SLC12A3_uc010ccn.2_Missense_Mutation_p.E130K	NM_001126108	NP_001119580	P55017	S12A3_HUMAN	solute carrier family 12, member 3 isoform 3	131	Cytoplasmic (Potential).				sodium ion transmembrane transport	apical plasma membrane|integral to plasma membrane|membrane fraction	sodium:chloride symporter activity			ovary(2)|breast(1)	3					Bendroflumethiazide(DB00436)|Benzthiazide(DB00562)|Chlorothiazide(DB00880)|Diazoxide(DB01119)|Hydrochlorothiazide(DB00999)|Metolazone(DB00524)|Polythiazide(DB01324)|Quinethazone(DB01325)	GAAGAACCCCGAGGAGCCAGT	0.652		NaN											0	0	0	0.004672	0	3	8									
GINS3	64785	broad.mit.edu	37	16	58438619	58438619	+	Missense_Mutation	SNP	G	G	C	rs144642422		TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr16:58438619G>C	uc002enh.3	+	3	845	c.637G>C	c.(637-639)GAT>CAT	p.D213H	GINS3_uc010cdj.2_Missense_Mutation_p.D252H|GINS3_uc002enj.3_Missense_Mutation_p.D135H|GINS3_uc002eni.3_3'UTR	NM_022770	NP_073607	Q9BRX5	PSF3_HUMAN	GINS complex subunit 3 isoform b	213					DNA replication	nucleus					0						AAAATTCACTGATATGGAAGA	0.478		NaN											0	0	0	0.001984	0	7	19									
PARD6A	50855	broad.mit.edu	37	16	67696467	67696467	+	Silent	SNP	C	C	T			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr16:67696467C>T	uc002ett.2	+	3	1049	c.958C>T	c.(958-960)CTG>TTG	p.L320L	ACD_uc002etp.3_5'Flank|ACD_uc002etq.3_5'Flank|ACD_uc002etr.3_5'Flank|ACD_uc010vjt.1_5'Flank|PARD6A_uc002ets.2_Silent_p.L319L|PARD6A_uc002etu.2_Silent_p.L144L	NM_016948	NP_058644	Q9NPB6	PAR6A_HUMAN	par-6 partitioning defective 6 homolog alpha	320					cell cycle|cell division|cell-cell junction maintenance|tight junction assembly|viral reproduction	cytosol|nucleus|ruffle|tight junction	GTP-dependent protein binding|Rho GTPase binding|transcription factor binding			ovary(1)	1		Acute lymphoblastic leukemia(13;3.76e-06)|all_hematologic(13;0.000303)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0143)|Epithelial(162;0.047)|all cancers(182;0.228)		CCGCAGCTCTCTGCCCTCCCT	0.637		NaN											0	0	0	0.010729	0	9	19									
ESRP2	80004	broad.mit.edu	37	16	68264333	68264333	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr16:68264333C>G	uc010cfa.1	-	14	2241	c.2053G>C	c.(2053-2055)GCT>CCT	p.A685P	ESRP2_uc002evp.1_RNA|ESRP2_uc002evq.1_Missense_Mutation_p.A675P	NM_024939	NP_079215	Q9H6T0	ESRP2_HUMAN	RNA binding motif protein 35B	685					mRNA processing|regulation of RNA splicing|RNA splicing	nucleus	mRNA binding|nucleotide binding			ovary(1)	1						TTCATACCAGCCGTGTATGGG	0.617		NaN											0	0	0	0.014323	0	24	55									
SGK494	124923	broad.mit.edu	37	17	26940312	26940312	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr17:26940312C>G	uc002hbr.1	-	3	408	c.376G>C	c.(376-378)GAT>CAT	p.D126H	SGK494_uc010waq.1_Missense_Mutation_p.D126H|SGK494_uc010war.1_RNA|uc010crq.1_5'Flank|uc002hbs.1_Intron	NM_144610	NP_653211			uncharacterized serine/threonine-protein kinase												0						TGGGTGCAATCTAGCACCTTG	0.458		NaN									OREG0024279	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.021523	0	23	39									
SGK494	124923	broad.mit.edu	37	17	26940461	26940461	+	Silent	SNP	C	C	T			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr17:26940461C>T	uc002hbr.1	-	2	353	c.321G>A	c.(319-321)CTG>CTA	p.L107L	SGK494_uc010waq.1_Silent_p.L107L|SGK494_uc010war.1_RNA|uc010crq.1_5'Flank|uc002hbs.1_Intron	NM_144610	NP_653211			uncharacterized serine/threonine-protein kinase												0						GACTTACCTTCAGCTGCTGCT	0.502		NaN									OREG0024279	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.016522	0	20	41									
KIAA0100	9703	broad.mit.edu	37	17	26942708	26942708	+	Missense_Mutation	SNP	C	C	A			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr17:26942708C>A	uc002hbu.2	-	38	6598	c.6499G>T	c.(6499-6501)GAC>TAC	p.D2167Y	SGK494_uc010waq.1_5'Flank|SGK494_uc010war.1_5'Flank|SGK494_uc002hbr.1_5'Flank|uc002hbs.1_Intron|KIAA0100_uc002hbt.2_Missense_Mutation_p.D496Y	NM_014680	NP_055495	Q14667	K0100_HUMAN	hypothetical protein LOC9703 precursor	2167						extracellular region				ovary(2)|breast(1)|skin(1)	4	Lung NSC(42;0.00431)					TTGCGGCTGTCCCTTTTGACA	0.557		NaN											1	0	6.40141e-05	0.010729	6.57577e-05	11	39									
KIAA0100	9703	broad.mit.edu	37	17	26942717	26942717	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr17:26942717C>T	uc002hbu.2	-	38	6589	c.6490G>A	c.(6490-6492)GTC>ATC	p.V2164I	SGK494_uc010waq.1_5'Flank|SGK494_uc010war.1_5'Flank|SGK494_uc002hbr.1_5'Flank|uc002hbs.1_Intron|KIAA0100_uc002hbt.2_Missense_Mutation_p.V493I	NM_014680	NP_055495	Q14667	K0100_HUMAN	hypothetical protein LOC9703 precursor	2164						extracellular region				ovary(2)|breast(1)|skin(1)	4	Lung NSC(42;0.00431)					TCCCTTTTGACAGCCATGGCA	0.567		NaN											0	0	0	0.013537	0	13	34									
KIAA0100	9703	broad.mit.edu	37	17	26943203	26943203	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr17:26943203C>T	uc002hbu.2	-	37	6400	c.6301G>A	c.(6301-6303)GAC>AAC	p.D2101N	SGK494_uc010waq.1_5'Flank|SGK494_uc010war.1_5'Flank|SGK494_uc002hbr.1_5'Flank|uc002hbs.1_Intron|KIAA0100_uc002hbt.2_Missense_Mutation_p.D430N	NM_014680	NP_055495	Q14667	K0100_HUMAN	hypothetical protein LOC9703 precursor	2101						extracellular region				ovary(2)|breast(1)|skin(1)	4	Lung NSC(42;0.00431)					TTGTCAATGTCATCCACAGGG	0.478		NaN											0	0	0	0.008291	0	11	28									
KIAA0100	9703	broad.mit.edu	37	17	26945827	26945827	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr17:26945827C>G	uc002hbu.2	-	32	5904	c.5805G>C	c.(5803-5805)CAG>CAC	p.Q1935H	KIAA0100_uc002hbt.2_Missense_Mutation_p.Q264H	NM_014680	NP_055495	Q14667	K0100_HUMAN	hypothetical protein LOC9703 precursor	1935						extracellular region				ovary(2)|breast(1)|skin(1)	4	Lung NSC(42;0.00431)					AGAGGAACCTCTGCAGTTCTA	0.478		NaN											0	0	0	0.005443	0	24	56									
SUPT6H	6830	broad.mit.edu	37	17	27008291	27008291	+	Nonsense_Mutation	SNP	C	C	G			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr17:27008291C>G	uc002hby.2	+	12	1457	c.1367C>G	c.(1366-1368)TCA>TGA	p.S456*	SUPT6H_uc010crt.2_Nonsense_Mutation_p.S456*	NM_003170	NP_003161	Q7KZ85	SPT6H_HUMAN	suppressor of Ty 6 homolog	456					chromatin remodeling|regulation of transcription elongation, DNA-dependent|regulation of transcription from RNA polymerase II promoter	nucleus	hydrolase activity, acting on ester bonds|RNA binding|sequence-specific DNA binding transcription factor activity			ovary(2)|skin(1)	3	Lung NSC(42;0.00431)					GATGTCCAATCAATGGATGAG	0.443		NaN											0	0	0	0.010504	0	20	41									
TP53I13	90313	broad.mit.edu	37	17	27895814	27895814	+	Missense_Mutation	SNP	T	T	C			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr17:27895814T>C	uc002hee.2	+	1	76	c.38T>C	c.(37-39)CTG>CCG	p.L13P	ABHD15_uc002hed.1_5'Flank	NM_138349	NP_612358	Q8NBR0	P5I13_HUMAN	tumor protein p53 inducible protein 13	13						cytoplasm|integral to membrane|plasma membrane					0				READ - Rectum adenocarcinoma(3;0.236)		CTGCTTCTCCTGGCAGCCCTC	0.468		NaN											0	0	0	0.020292	0	13	18									
AP2B1	163	broad.mit.edu	37	17	33966732	33966732	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr17:33966732G>A	uc002hjr.2	+	11	1579	c.1390G>A	c.(1390-1392)GAG>AAG	p.E464K	AP2B1_uc002hjq.2_Missense_Mutation_p.E464K|AP2B1_uc010wci.1_Missense_Mutation_p.E426K|AP2B1_uc002hjs.2_Missense_Mutation_p.E407K|AP2B1_uc002hjt.2_Missense_Mutation_p.E464K|AP2B1_uc010ctv.2_Missense_Mutation_p.E464K|AP2B1_uc010wcj.1_Missense_Mutation_p.E201K	NM_001282	NP_001273	P63010	AP2B1_HUMAN	adaptor-related protein complex 2, beta 1	464					axon guidance|epidermal growth factor receptor signaling pathway|intracellular protein transport|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|regulation of defense response to virus by virus|synaptic transmission|vesicle-mediated transport|viral reproduction	clathrin adaptor complex|coated pit|cytosol|endocytic vesicle membrane|plasma membrane	clathrin binding|protein transporter activity			ovary(1)	1		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0227)		CAATGCAGATGAGTTACTAGA	0.438		NaN											0	0	0	0.004007	0	16	50									
AATF	26574	broad.mit.edu	37	17	35310257	35310257	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr17:35310257G>A	uc002hni.2	+	3	606	c.355G>A	c.(355-357)GAG>AAG	p.E119K	AATF_uc002hnj.2_RNA	NM_012138	NP_036270	Q9NY61	AATF_HUMAN	apoptosis antagonizing transcription factor	119	Glu-rich.				anti-apoptosis|apoptosis|induction of apoptosis by extracellular signals|negative regulation of superoxide anion generation|nerve growth factor receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to DNA damage stimulus	centrosome|focal adhesion|nucleolus	leucine zipper domain binding|sequence-specific DNA binding transcription factor activity				0		Breast(25;0.00607)				GGAATATGATGAGGACGACCT	0.498		NaN											0	0	0	0.013537	0	12	49									
CACNB1	782	broad.mit.edu	37	17	37343111	37343111	+	Silent	SNP	G	G	A			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr17:37343111G>A	uc002hrm.1	-	5	639	c.486C>T	c.(484-486)CCC>CCT	p.P162P	CACNB1_uc002hrl.1_5'UTR|CACNB1_uc002hrn.2_Silent_p.P162P|CACNB1_uc002hro.2_Silent_p.P162P|CACNB1_uc002hrp.1_Silent_p.P162P|CACNB1_uc010web.1_Silent_p.P115P	NM_000723	NP_000714	Q02641	CACB1_HUMAN	calcium channel, voltage-dependent, beta 1	162					axon guidance	voltage-gated calcium channel complex				large_intestine(1)|ovary(1)	2					Ibutilide(DB00308)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Verapamil(DB00661)	CCAGTTTGACGGGGCTGGGAA	0.592		NaN											0	0	0	0.014323	0	22	40									
FBXL20	84961	broad.mit.edu	37	17	37431242	37431242	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr17:37431242G>C	uc010wed.1	-	10	1029	c.808C>G	c.(808-810)CAG>GAG	p.Q270E	FBXL20_uc002hrt.2_Missense_Mutation_p.Q270E|FBXL20_uc010cvu.2_Missense_Mutation_p.Q238E	NM_032875	NP_116264	Q96IG2	FXL20_HUMAN	F-box and leucine-rich repeat protein 20	270	LRR 8.					cytoplasm				ovary(1)	1			LUAD - Lung adenocarcinoma(14;0.146)			GGGCAGTTCTGACCTAGAGCA	0.418		NaN											0	0	0	0.010729	0	11	48									
CDK12	51755	broad.mit.edu	37	17	37618889	37618889	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr17:37618889G>A	uc010cvv.2	+	1	1151	c.565G>A	c.(565-567)GAG>AAG	p.E189K	CDK12_uc010wef.1_Missense_Mutation_p.E189K|CDK12_uc002hrw.3_Missense_Mutation_p.E189K	NM_016507	NP_057591	Q9NYV4	CDK12_HUMAN	Cdc2-related kinase, arginine/serine-rich	189					mRNA processing|phosphorylation of RNA polymerase II C-terminal domain|protein autophosphorylation|regulation of MAP kinase activity|RNA splicing	nuclear cyclin-dependent protein kinase holoenzyme complex|nuclear speck|nucleolus	ATP binding|cyclin-dependent protein kinase activity|protein binding|RNA polymerase II carboxy-terminal domain kinase activity			ovary(10)|lung(4)|breast(2)|skin(2)|large_intestine(1)	19						GAAAGAACGGGAGCTGAAGTC	0.502		NaN								TCGA Ovarian(9;0.13)			0	0	0	0.004482	0	8	28									
COASY	80347	broad.mit.edu	37	17	40717318	40717318	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr17:40717318C>G	uc002hzz.2	+	7	1533	c.1376C>G	c.(1375-1377)GCT>GGT	p.A459G	COASY_uc010cyj.2_Missense_Mutation_p.A488G|COASY_uc002iab.2_Missense_Mutation_p.A164G|COASY_uc002iad.2_Missense_Mutation_p.A459G|COASY_uc002iac.2_Missense_Mutation_p.A459G|COASY_uc002iae.2_Missense_Mutation_p.A254G|MLX_uc002iaf.2_5'Flank|MLX_uc002iag.2_5'Flank|MLX_uc002iah.2_5'Flank	NM_001042529	NP_001035994	Q13057	COASY_HUMAN	coenzyme A synthase isoform a	459	DPCK.				coenzyme A biosynthetic process|pantothenate metabolic process	mitochondrial outer membrane	ATP binding|dephospho-CoA kinase activity|pantetheine-phosphate adenylyltransferase activity				0		all_cancers(22;1.06e-05)|Breast(137;0.000153)|all_epithelial(22;0.000344)		BRCA - Breast invasive adenocarcinoma(366;0.13)		ATGGATCGGGCTGTGGCTGAG	0.577		NaN											0	0	0	0.014758	0	5	94									
ITGA2B	3674	broad.mit.edu	37	17	42463435	42463435	+	Missense_Mutation	SNP	A	A	G			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr17:42463435A>G	uc002igt.1	-	2	285	c.253T>C	c.(253-255)TTC>CTC	p.F85L		NM_000419	NP_000410	P08514	ITA2B_HUMAN	integrin alpha 2b preproprotein	85	Extracellular (Potential).|FG-GAP 1.				axon guidance|integrin-mediated signaling pathway|platelet activation|platelet degranulation	integrin complex|platelet alpha granule membrane	identical protein binding|receptor activity			ovary(2)|lung(1)	3		Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.191)	Tirofiban(DB00775)	GGGCACAGGAACACGCCGCCC	0.697		NaN											0	0	0	0.004672	0	3	10									
ITGB3	3690	broad.mit.edu	37	17	45387520	45387520	+	Missense_Mutation	SNP	T	T	C			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr17:45387520T>C	uc002ilj.2	+	15	2337	c.2317T>C	c.(2317-2319)TAT>CAT	p.Y773H	ITGB3_uc010wkr.1_Intron	NM_000212	NP_000203	P05106	ITB3_HUMAN	integrin beta chain, beta 3 precursor	773	Cytoplasmic (Potential).				activation of protein kinase activity|angiogenesis involved in wound healing|axon guidance|cell-matrix adhesion|integrin-mediated signaling pathway|interspecies interaction between organisms|leukocyte migration|negative regulation of lipid storage|negative regulation of lipid transport|negative regulation of lipoprotein metabolic process|negative regulation of low-density lipoprotein particle receptor biosynthetic process|negative regulation of macrophage derived foam cell differentiation|platelet activation|platelet degranulation|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of vascular endothelial growth factor receptor signaling pathway|regulation of bone resorption|smooth muscle cell migration|tube development	alphav-beta3 integrin-vitronectin complex|integrin complex|platelet alpha granule membrane	cell adhesion molecule binding|identical protein binding|platelet-derived growth factor receptor binding|receptor activity|vascular endothelial growth factor receptor 2 binding			central_nervous_system(5)|large_intestine(1)	6					Abciximab(DB00054)|Tirofiban(DB00775)	CAACCCACTGTATAAAGAGGC	0.448		NaN											0	0	0	0.00499	0	14	35									
KPNB1	3837	broad.mit.edu	37	17	45727754	45727754	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr17:45727754C>G	uc002ilt.1	+	2	379	c.43C>G	c.(43-45)CGG>GGG	p.R15G	KPNB1_uc010wkw.1_5'Flank	NM_002265	NP_002256	Q14974	IMB1_HUMAN	karyopherin beta 1	15					DNA fragmentation involved in apoptotic nuclear change|NLS-bearing substrate import into nucleus|protein import into nucleus, translocation|ribosomal protein import into nucleus|viral genome transport in host cell|viral infectious cycle	cytosol|nuclear pore|nucleoplasm	nuclear localization sequence binding|protein domain specific binding|zinc ion binding			ovary(1)|pancreas(1)|skin(1)	3						CCCCCTAGATCGGCTGGAGCT	0.721		NaN											0	0	0	0.009096	0	4	12									
MRPL10	124995	broad.mit.edu	37	17	45901691	45901691	+	Silent	SNP	G	G	C			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr17:45901691G>C	uc002ilz.2	-	5	692	c.666C>G	c.(664-666)CTC>CTG	p.L222L	OSBPL7_uc002ilx.1_5'Flank|MRPL10_uc010wky.1_Silent_p.L183L|MRPL10_uc002ily.2_Silent_p.L232L	NM_145255	NP_660298	Q7Z7H8	RM10_HUMAN	mitochondrial ribosomal protein L10 precursor	222					ribosome biogenesis|translation	mitochondrial large ribosomal subunit	structural constituent of ribosome			ovary(1)	1						GCTGGTGCTGGAGCAGGGAGT	0.607		NaN											0	0	0	0.020292	0	13	42									
ANKFN1	162282	broad.mit.edu	37	17	54526504	54526504	+	Silent	SNP	G	G	A			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr17:54526504G>A	uc002iun.1	+	10	1208	c.1173G>A	c.(1171-1173)CTG>CTA	p.L391L		NM_153228	NP_694960	Q8N957	ANKF1_HUMAN	ankyrin-repeat and fibronectin type III domain	391										large_intestine(1)|ovary(1)	2						TGGAAGGTCTGCTGCAGCAGG	0.468		NaN											0	0	0	0.008871	0	17	47									
BCAS3	54828	broad.mit.edu	37	17	59067473	59067473	+	Missense_Mutation	SNP	A	A	G			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr17:59067473A>G	uc002iyv.3	+	15	1472	c.1363A>G	c.(1363-1365)ATG>GTG	p.M455V	BCAS3_uc010wow.1_Missense_Mutation_p.M242V|BCAS3_uc002iyu.3_Missense_Mutation_p.M455V|BCAS3_uc002iyw.3_Missense_Mutation_p.M451V|BCAS3_uc002iyx.1_Missense_Mutation_p.M270V|BCAS3_uc002iyy.3_Missense_Mutation_p.M226V|BCAS3_uc002iyz.3_Missense_Mutation_p.M9V|BCAS3_uc002iza.3_Missense_Mutation_p.M9V	NM_001099432	NP_001092902	Q9H6U6	BCAS3_HUMAN	breast carcinoma amplified sequence 3 isoform 1	455						nucleus				ovary(2)|central_nervous_system(2)|skin(1)	5			BRCA - Breast invasive adenocarcinoma(1;3.11e-12)|Epithelial(12;8.2e-07)|all cancers(12;5.33e-06)			AGTGAATCGCATGAGCCGTTT	0.512		NaN											0	0	0	0.004007	0	17	38									
LRRC37A3	374819	broad.mit.edu	37	17	62864655	62864655	+	Splice_Site	SNP	C	C	G			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr17:62864655C>G	uc002jey.2	-	9	3510	c.2979_splice	c.e9-1	p.L993_splice	LRRC37A3_uc010wqg.1_Splice_Site_p.L111_splice|LRRC37A3_uc010wqf.1_Splice_Site_p.L31_splice|LRRC37A3_uc010dek.1_Splice_Site	NM_199340	NP_955372	O60309	L37A3_HUMAN	leucine rich repeat containing 37, member A3							integral to membrane					0						TCCCATGTCTCTGAAGAAGAA	0.353		NaN											0	0	0	0.005443	0	21	69									
NUP85	79902	broad.mit.edu	37	17	73231679	73231679	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr17:73231679G>A	uc002jng.1	+	19	2136	c.1876G>A	c.(1876-1878)GAC>AAC	p.D626N	NUP85_uc010dgd.1_Missense_Mutation_p.D581N|NUP85_uc010wrv.1_Missense_Mutation_p.D580N|NUP85_uc002jnh.1_Missense_Mutation_p.D229N	NM_024844	NP_079120	Q9BW27	NUP85_HUMAN	nucleoporin 85	626					carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytosol|nuclear membrane|Nup107-160 complex|spindle	protein binding			ovary(1)	1	all_lung(278;0.14)|Lung NSC(278;0.168)		all cancers(21;3.45e-06)			GCAGGATGATGACATAGAGAC	0.502		NaN											0	0	0	0.014323	0	19	31									
COLEC12	81035	broad.mit.edu	37	18	346369	346369	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr18:346369G>A	uc002kkm.2	-	5	1468	c.1253C>T	c.(1252-1254)TCA>TTA	p.S418L		NM_130386	NP_569057	Q5KU26	COL12_HUMAN	collectin sub-family member 12	418	Extracellular (Potential).				carbohydrate mediated signaling|innate immune response|phagocytosis, recognition|protein homooligomerization	collagen|integral to membrane	galactose binding|low-density lipoprotein particle binding|metal ion binding|pattern recognition receptor activity|scavenger receptor activity			ovary(1)|pancreas(1)	2		all_cancers(4;0.0442)|Myeloproliferative disorder(11;0.0426)				CATAATCACTGATAAGTTGGC	0.378		NaN											0	0	0	0.001984	0	7	53									
MYOM1	8736	broad.mit.edu	37	18	3119940	3119940	+	Silent	SNP	G	G	A			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr18:3119940G>A	uc002klp.2	-	20	3379	c.3045C>T	c.(3043-3045)AAC>AAT	p.N1015N	MYOM1_uc002klq.2_Silent_p.N919N	NM_003803	NP_003794	P52179	MYOM1_HUMAN	myomesin 1 isoform a	1015	Fibronectin type-III 4.					striated muscle myosin thick filament	structural constituent of muscle			ovary(3)|central_nervous_system(1)|pancreas(1)	5						GCCCAGCCATGTTCATGGCTG	0.502		NaN											0	0	0	0.014758	0	3	4									
LAMA3	3909	broad.mit.edu	37	18	21395492	21395492	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr18:21395492G>C	uc002kuq.2	+	17	2088	c.2002G>C	c.(2002-2004)GAT>CAT	p.D668H	LAMA3_uc002kur.2_Missense_Mutation_p.D668H	NM_198129	NP_937762	Q16787	LAMA3_HUMAN	laminin alpha 3 subunit isoform 1	668	Domain V.|Laminin EGF-like 7.				cell adhesion|epidermis development|hemidesmosome assembly|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|skin(2)|central_nervous_system(1)	11	all_cancers(21;7.81e-05)|all_epithelial(16;4.45e-07)|Lung NSC(20;0.00156)|all_lung(20;0.00508)|Colorectal(14;0.0202)|Ovarian(20;0.17)				Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	CACCTGTGAAGATGGATATTT	0.453		NaN											0	0	0	0.004482	0	9	36									
LAMA3	3909	broad.mit.edu	37	18	21396406	21396406	+	Missense_Mutation	SNP	G	G	T			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr18:21396406G>T	uc002kuq.2	+	18	2188	c.2102G>T	c.(2101-2103)GGA>GTA	p.G701V	LAMA3_uc002kur.2_Missense_Mutation_p.G701V	NM_198129	NP_937762	Q16787	LAMA3_HUMAN	laminin alpha 3 subunit isoform 1	701	Domain V.|Laminin EGF-like 8.				cell adhesion|epidermis development|hemidesmosome assembly|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|skin(2)|central_nervous_system(1)	11	all_cancers(21;7.81e-05)|all_epithelial(16;4.45e-07)|Lung NSC(20;0.00156)|all_lung(20;0.00508)|Colorectal(14;0.0202)|Ovarian(20;0.17)				Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GGGCCCTCGGGAGTGTGCCAG	0.552		NaN											1	0	2.68362e-12	0.013537	2.89174e-12	10	28									
SLC14A2	8170	broad.mit.edu	37	18	43205653	43205653	+	Silent	SNP	C	C	G			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr18:43205653C>G	uc010dnj.2	+	4	477	c.156C>G	c.(154-156)CTC>CTG	p.L52L	SLC14A2_uc002lbb.2_Silent_p.L52L|SLC14A2_uc002lbe.2_Silent_p.L52L	NM_007163	NP_009094	Q15849	UT2_HUMAN	solute carrier family 14 (urea transporter),	52						apical plasma membrane|integral to membrane|membrane fraction	protein binding|urea transmembrane transporter activity			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)|skin(1)	4						AAAAGGATCTCCGGTCTTCCA	0.468		NaN											0	0	0	0.010729	0	10	20									
ZNF266	10781	broad.mit.edu	37	19	9528554	9528554	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr19:9528554G>A	uc002mll.2	-	2	331	c.65C>T	c.(64-66)TCT>TTT	p.S22F	ZNF266_uc002mlm.2_Missense_Mutation_p.S22F|ZNF266_uc002mln.2_Missense_Mutation_p.S22F|ZNF266_uc002mlo.2_Missense_Mutation_p.S22F|ZNF266_uc010dwp.2_Missense_Mutation_p.S22F|ZNF266_uc010dwq.2_Missense_Mutation_p.S22F	NM_198058	NP_932175	Q14584	ZN266_HUMAN	zinc finger protein 266	22	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						TTCCAGCCAAGAGATCAGACT	0.433		NaN											0	0	0	0.011902	0	44	89									
ZNF121	7675	broad.mit.edu	37	19	9676748	9676748	+	Missense_Mutation	SNP	T	T	A			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr19:9676748T>A	uc010xkp.1	-	4	1273	c.1041A>T	c.(1039-1041)AAA>AAT	p.K347N	ZNF121_uc010dwt.2_Missense_Mutation_p.K347N|ZNF121_uc010xkq.1_Missense_Mutation_p.K347N	NM_001008727	NP_001008727	P58317	ZN121_HUMAN	zinc finger protein 121	347	C2H2-type 10.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						CACGGAAGGTTTTCCCACATT	0.388		NaN											0	0	0	0.004007	0	16	36									
ANGPTL6	83854	broad.mit.edu	37	19	10204373	10204373	+	Missense_Mutation	SNP	T	T	C			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr19:10204373T>C	uc002mmx.1	-	4	1065	c.947A>G	c.(946-948)TAT>TGT	p.Y316C	ANGPTL6_uc002mmy.1_Missense_Mutation_p.Y316C	NM_031917	NP_114123	Q8NI99	ANGL6_HUMAN	angiopoietin-like 6 precursor	316	Fibrinogen C-terminal.				angiogenesis|cell differentiation|signal transduction	extracellular space	receptor binding				0			OV - Ovarian serous cystadenocarcinoma(20;3.58e-08)|Epithelial(33;2.5e-05)|all cancers(31;5.96e-05)			GCCCACCTTATAGTGCTGCCA	0.607		NaN											0	0	0	0.010729	0	12	57									
ICAM1	3383	broad.mit.edu	37	19	10395527	10395527	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr19:10395527C>G	uc002mnq.2	+	6	1568	c.1249C>G	c.(1249-1251)CCA>GCA	p.P417A	ICAM1_uc010xle.1_Missense_Mutation_p.P195A|ICAM4_uc002mnr.1_5'Flank|ICAM4_uc002mns.1_5'Flank|ICAM4_uc002mnt.1_5'Flank	NM_000201	NP_000192	P05362	ICAM1_HUMAN	intercellular adhesion molecule 1 precursor	417	Extracellular (Potential).|Ig-like C2-type 5.				adhesion to symbiont|heterophilic cell-cell adhesion|interferon-gamma-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|membrane to membrane docking|positive regulation of cellular extravasation|regulation of immune response|regulation of leukocyte mediated cytotoxicity|T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell|virion attachment, binding of host cell surface receptor	extracellular space|integral to plasma membrane	integrin binding|transmembrane receptor activity			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(20;1.39e-09)|Epithelial(33;2.81e-06)|all cancers(31;6.56e-06)		Natalizumab(DB00108)|Simvastatin(DB00641)	CCAGCAGACTCCAATGTGCCA	0.557		NaN											0	0	0	0.003163	0	15	34									
ICAM1	3383	broad.mit.edu	37	19	10395565	10395565	+	Silent	SNP	C	C	G			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr19:10395565C>G	uc002mnq.2	+	6	1606	c.1287C>G	c.(1285-1287)CTC>CTG	p.L429L	ICAM1_uc010xle.1_Silent_p.L207L|ICAM4_uc002mnr.1_5'Flank|ICAM4_uc002mns.1_5'Flank|ICAM4_uc002mnt.1_5'Flank	NM_000201	NP_000192	P05362	ICAM1_HUMAN	intercellular adhesion molecule 1 precursor	429	Extracellular (Potential).|Ig-like C2-type 5.				adhesion to symbiont|heterophilic cell-cell adhesion|interferon-gamma-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|membrane to membrane docking|positive regulation of cellular extravasation|regulation of immune response|regulation of leukocyte mediated cytotoxicity|T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell|virion attachment, binding of host cell surface receptor	extracellular space|integral to plasma membrane	integrin binding|transmembrane receptor activity			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(20;1.39e-09)|Epithelial(33;2.81e-06)|all cancers(31;6.56e-06)		Natalizumab(DB00108)|Simvastatin(DB00641)	TGCCCGAGCTCAAGTGTCTAA	0.582		NaN											0	0	0	0.016723	0	13	25									
EPOR	2057	broad.mit.edu	37	19	11488763	11488763	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr19:11488763C>T	uc002mrj.1	-	8	1560	c.1424G>A	c.(1423-1425)GGA>GAA	p.G475E	EPOR_uc002mrh.2_Missense_Mutation_p.G134E|EPOR_uc002mri.2_Missense_Mutation_p.G302E|EPOR_uc002mrk.1_Missense_Mutation_p.G302E|EPOR_uc002mrl.1_RNA|EPOR_uc010xlx.1_RNA|EPOR_uc010xly.1_Missense_Mutation_p.G302E	NM_000121	NP_000112	P19235	EPOR_HUMAN	erythropoietin receptor precursor	475	Cytoplasmic (Potential).					extracellular region|integral to plasma membrane	erythropoietin receptor activity|identical protein binding			ovary(1)	1					Darbepoetin alfa(DB00012)|Epoetin alfa(DB00016)	CCCTTGGGCTCCCTGGGAGTC	0.592		NaN									OREG0025254	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.013726	0	32	85									
C19orf44	84167	broad.mit.edu	37	19	16614092	16614092	+	Missense_Mutation	SNP	T	T	G			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr19:16614092T>G	uc002neh.1	+	3	1049	c.976T>G	c.(976-978)TTA>GTA	p.L326V	MED26_uc002nee.2_Intron|C19orf44_uc002nef.1_Missense_Mutation_p.L326V|C19orf44_uc002neg.2_Missense_Mutation_p.L326V|C19orf44_uc010eai.1_RNA	NM_032207	NP_115583	Q9H6X5	CS044_HUMAN	hypothetical protein LOC84167	326											0						CTCAGTGTCTTTAAAGATGGG	0.562		NaN											0	0	0	0.010504	0	21	54									
PLVAP	83483	broad.mit.edu	37	19	17476312	17476312	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr19:17476312G>A	uc002ngk.1	-	3	1012	c.962C>T	c.(961-963)GCG>GTG	p.A321V		NM_031310	NP_112600	Q9BX97	PLVAP_HUMAN	plasmalemma vesicle associated protein	321	Potential.|Extracellular (Potential).					caveola|integral to membrane|perinuclear region of cytoplasm					0						CTTCTGTTTCGCCTCCTGACT	0.667		NaN											0	0	0	0.009096	0	4	33									
ZNF208	7757	broad.mit.edu	37	19	22154750	22154750	+	Missense_Mutation	SNP	T	T	C			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr19:22154750T>C	uc002nqp.2	-	6	2851	c.2702A>G	c.(2701-2703)TAC>TGC	p.Y901C	ZNF208_uc002nqo.1_Intron	NM_007153	NP_009084			zinc finger protein 208											ovary(5)|skin(2)	7		all_lung(12;0.0961)|Lung NSC(12;0.103)				TTCACATTTGTAGGGTGTCTC	0.418		NaN											0	0	0	0.01892	0	24	47									
MAP4K1	11184	broad.mit.edu	37	19	39106878	39106878	+	Silent	SNP	G	G	A			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr19:39106878G>A	uc002oix.1	-	4	378	c.270C>T	c.(268-270)TGC>TGT	p.C90C	MAP4K1_uc002oiy.1_Silent_p.C90C|MAP4K1_uc010xug.1_5'Flank|EIF3K_uc010xuh.1_5'Flank|EIF3K_uc002oiz.1_5'Flank|EIF3K_uc010xui.1_5'Flank	NM_007181	NP_009112	Q92918	M4K1_HUMAN	mitogen-activated protein kinase kinase kinase	90	Protein kinase.				activation of JUN kinase activity|peptidyl-serine phosphorylation		ATP binding|MAP kinase kinase kinase kinase activity|protein binding|small GTPase regulator activity			skin(4)|lung(3)|ovary(1)	8	all_cancers(60;6.42e-06)|Ovarian(47;0.103)		Lung(45;0.000751)|LUSC - Lung squamous cell carcinoma(53;0.00272)			AGAATTCCATGCAGATCCAGA	0.488		NaN											0	0	0	0.008291	0	10	24									
ZC3H4	23211	broad.mit.edu	37	19	47572355	47572355	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr19:47572355C>T	uc002pga.3	-	14	2430	c.2392G>A	c.(2392-2394)GAG>AAG	p.E798K	ZC3H4_uc002pgb.1_Intron	NM_015168	NP_055983	Q9UPT8	ZC3H4_HUMAN	zinc finger CCCH-type containing 4	798	Potential.						nucleic acid binding|zinc ion binding			skin(4)|ovary(2)	6		all_cancers(25;3.3e-08)|all_epithelial(76;2.28e-06)|all_lung(116;7.86e-06)|Lung NSC(112;2.31e-05)|all_neural(266;0.026)|Ovarian(192;0.0392)|Breast(70;0.0889)		OV - Ovarian serous cystadenocarcinoma(262;5.76e-05)|all cancers(93;7.69e-05)|Epithelial(262;0.00354)|GBM - Glioblastoma multiforme(486;0.0372)		GTGCCTTCCTCATTCTCCCGG	0.677		NaN											0	0	0	0.00623	0	38	95									
ZNF667	63934	broad.mit.edu	37	19	56953098	56953098	+	Silent	SNP	C	C	T			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr19:56953098C>T	uc002qnd.2	-	5	1428	c.1266G>A	c.(1264-1266)AAG>AAA	p.K422K	ZNF667_uc010etl.2_Silent_p.K204K|ZNF667_uc002qne.2_Silent_p.K422K|ZNF667_uc010etm.2_Silent_p.K365K	NM_022103	NP_071386	Q5HYK9	ZN667_HUMAN	zinc finger protein 667	422	C2H2-type 9.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			pancreas(1)	1		Colorectal(82;0.000256)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0615)		CAGAAAACATCTTCCCACATT	0.343		NaN											0	0	0	0.006214	0	10	19									
ZSCAN1	284312	broad.mit.edu	37	19	58564970	58564970	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr19:58564970C>T	uc002qrc.1	+	6	1025	c.778C>T	c.(778-780)CGC>TGC	p.R260C		NM_182572	NP_872378	Q8NBB4	ZSCA1_HUMAN	zinc finger and SCAN domain containing 1	260					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2		Colorectal(82;5.46e-05)|all_neural(62;0.0182)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0152)		CCAGAGCGGCCGCCACCAGCC	0.627		NaN											0	0	0	0.001168	0	6	39									
C2orf43	60526	broad.mit.edu	37	2	20901362	20901362	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr2:20901362C>T	uc002rec.2	-	6	787	c.754G>A	c.(754-756)GAT>AAT	p.D252N	C2orf43_uc002rea.1_Missense_Mutation_p.D252N|C2orf43_uc002reb.1_RNA|C2orf43_uc010yka.1_3'UTR|C2orf43_uc010ykb.1_Missense_Mutation_p.D122N|C2orf43_uc010ykc.1_Missense_Mutation_p.D204N|C2orf43_uc010ykd.1_3'UTR|C2orf43_uc010yke.1_Missense_Mutation_p.D210N|C2orf43_uc010ykf.1_Missense_Mutation_p.D122N	NM_021925	NP_068744	Q9H6V9	CB043_HUMAN	hypothetical protein LOC60526	252											0	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GTTTCGTCATCTCTCTTCACC	0.383		NaN											0	0	0	0.013114	0	40	125									
C2orf43	60526	broad.mit.edu	37	2	20901369	20901369	+	Silent	SNP	C	C	T			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr2:20901369C>T	uc002rec.2	-	6	780	c.747G>A	c.(745-747)GTG>GTA	p.V249V	C2orf43_uc002rea.1_Silent_p.V249V|C2orf43_uc002reb.1_RNA|C2orf43_uc010yka.1_3'UTR|C2orf43_uc010ykb.1_Silent_p.V119V|C2orf43_uc010ykc.1_Silent_p.V201V|C2orf43_uc010ykd.1_3'UTR|C2orf43_uc010yke.1_Silent_p.V207V|C2orf43_uc010ykf.1_Silent_p.V119V	NM_021925	NP_068744	Q9H6V9	CB043_HUMAN	hypothetical protein LOC60526	249											0	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CATCTCTCTTCACCACCTCCA	0.373		NaN											0	0	0	0.011902	0	41	127									
NCOA1	8648	broad.mit.edu	37	2	24930108	24930108	+	Nonsense_Mutation	SNP	C	C	G			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr2:24930108C>G	uc002rfk.2	+	11	2027	c.1769C>G	c.(1768-1770)TCA>TGA	p.S590*	NCOA1_uc010eye.2_Nonsense_Mutation_p.S590*|NCOA1_uc002rfi.2_Nonsense_Mutation_p.S439*|NCOA1_uc002rfj.2_Nonsense_Mutation_p.S590*|NCOA1_uc002rfl.2_Nonsense_Mutation_p.S590*	NM_003743	NP_003734	Q15788	NCOA1_HUMAN	nuclear receptor coactivator 1 isoform 1	590	Ser-rich.								PAX3/NCOA1(8)	soft_tissue(8)|ovary(1)|lung(1)|skin(1)	11	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GAGATTGCCTCAATTTTAAAT	0.408		NaN	T	PAX3	alveolar rhadomyosarcoma								0	0	0	0.00308	0	7	46									
FAHD2B	151313	broad.mit.edu	37	2	97757424	97757424	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr2:97757424C>T	uc002sxm.2	-	2	171	c.20G>A	c.(19-21)AGA>AAA	p.R7K		NM_199336	NP_955368	Q6P2I3	FAH2B_HUMAN	fumarylacetoacetate hydrolase domain containing	7							hydrolase activity|metal ion binding				0						GAGTAATCTTCTTCTACCAGA	0.547		NaN											0	0	0	0.007413	0	20	50									
MYO7B	4648	broad.mit.edu	37	2	128393891	128393891	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr2:128393891G>C	uc002top.2	+	44	6090	c.6037G>C	c.(6037-6039)GAG>CAG	p.E2013Q	MYO7B_uc002tos.1_Missense_Mutation_p.E123Q|MYO7B_uc002tot.2_Missense_Mutation_p.E123Q	NM_001080527	NP_001073996	Q6PIF6	MYO7B_HUMAN	myosin VIIB	2013	FERM 2.					apical plasma membrane|myosin complex	actin binding|ATP binding|motor activity			ovary(1)|pancreas(1)	2	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0753)		CGCCTTCTTCGAGGTGAAGGT	0.612		NaN											0	0	0	0.008291	0	11	26									
LRP1B	53353	broad.mit.edu	37	2	141283479	141283479	+	Missense_Mutation	SNP	G	G	T			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr2:141283479G>T	uc002tvj.1	-	49	8932	c.7960C>A	c.(7960-7962)CTG>ATG	p.L2654M		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	2654	Extracellular (Potential).|LDL-receptor class A 14.			LP -> CQ (in Ref. 2; AAL38108).	protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		CAGGTTGGCAGAACACACAGT	0.403		NaN								TSP Lung(27;0.18)			1	0	3.07112e-06	0.010729	3.19203e-06	12	37									
TTN	7273	broad.mit.edu	37	2	179415741	179415741	+	Missense_Mutation	SNP	C	C	A			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr2:179415741C>A	uc010zfg.1	-	285	84037	c.83813G>T	c.(83812-83814)AGC>ATC	p.S27938I	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.S21633I|TTN_uc010zfi.1_Missense_Mutation_p.S21566I|TTN_uc010zfj.1_Missense_Mutation_p.S21441I	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	28865							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TGAGGGCGGGCTTATAGTTCC	0.388		NaN											1	0	0.000602214	0.014758	0.00061384	5	20									
TTN	7273	broad.mit.edu	37	2	179464145	179464145	+	Missense_Mutation	SNP	A	A	T			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr2:179464145A>T	uc010zfg.1	-	239	48895	c.48671T>A	c.(48670-48672)ATA>AAA	p.I16224K	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.I9919K|TTN_uc010zfi.1_Missense_Mutation_p.I9852K|TTN_uc010zfj.1_Missense_Mutation_p.I9727K	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	17151							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTCAAATTTTATGGGTCCCAC	0.363		NaN											0	0	0	0.013537	0	13	35									
ZSWIM2	151112	broad.mit.edu	37	2	187713754	187713754	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr2:187713754C>G	uc002upu.1	-	1	144	c.104G>C	c.(103-105)CGA>CCA	p.R35P		NM_182521	NP_872327	Q8NEG5	ZSWM2_HUMAN	zinc finger, SWIM domain containing 2	35					apoptosis		zinc ion binding			ovary(2)|skin(1)	3			OV - Ovarian serous cystadenocarcinoma(117;0.0274)|Epithelial(96;0.164)			GCCCATCTCTCGTAGGAGGTA	0.597		NaN											0	0	0	0.006214	0	10	25									
ICA1L	130026	broad.mit.edu	37	2	203653802	203653802	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr2:203653802C>G	uc002uzh.1	-	12	1158	c.994G>C	c.(994-996)GAT>CAT	p.D332H	ICA1L_uc002uzi.1_Missense_Mutation_p.D332H	NM_138468	NP_612477	Q8NDH6	ICA1L_HUMAN	islet cell autoantigen 1,69kDa-like isoform 1	332											0						ACAGGTAGATCTTTTGCAACT	0.323		NaN											0	0	0	0.003163	0	14	39									
SGPP2	130367	broad.mit.edu	37	2	223423425	223423425	+	Silent	SNP	C	C	G			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr2:223423425C>G	uc010zlo.1	+	5	1008	c.1008C>G	c.(1006-1008)CTC>CTG	p.L336L	SGPP2_uc010zlp.1_Silent_p.L208L	NM_152386	NP_689599	Q8IWX5	SGPP2_HUMAN	sphingosine-1-phosphate phosphotase 2	336	Helical; (Potential).				sphingosine metabolic process	endoplasmic reticulum membrane|integral to membrane	dihydrosphingosine-1-phosphate phosphatase activity|sphingosine-1-phosphate phosphatase activity			central_nervous_system(1)|skin(1)	2		Renal(207;0.0376)		Epithelial(121;2.08e-09)|all cancers(144;9.25e-07)|LUSC - Lung squamous cell carcinoma(224;0.011)|Lung(261;0.0143)		TGTTGATCCTCTTGGTTCGTC	0.473		NaN											0	0	0	0.020292	0	14	52									
SCG2	7857	broad.mit.edu	37	2	224463700	224463700	+	Missense_Mutation	SNP	C	C	G	rs137998511		TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr2:224463700C>G	uc002vnm.2	-	2	434	c.301G>C	c.(301-303)GAG>CAG	p.E101Q		NM_003469	NP_003460	P13521	SCG2_HUMAN	secretogranin II precursor	101					angiogenesis|endothelial cell migration|eosinophil chemotaxis|induction of positive chemotaxis|inflammatory response|MAPKKK cascade|negative regulation of apoptosis|negative regulation of endothelial cell proliferation|positive regulation of endothelial cell proliferation|protein secretion	extracellular space|stored secretory granule	chemoattractant activity|cytokine activity			ovary(1)	1		Renal(207;0.0112)|Lung NSC(271;0.0185)|all_lung(227;0.0271)		Epithelial(121;8.16e-11)|all cancers(144;4.66e-08)|Lung(261;0.00714)|LUSC - Lung squamous cell carcinoma(224;0.008)		GAATCCCTCTCGGGCAAGTGG	0.453		NaN											0	0	0	0.021523	0	26	51									
UBOX5	22888	broad.mit.edu	37	20	3102035	3102035	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr20:3102035G>A	uc002whw.2	-	3	1420	c.1250C>T	c.(1249-1251)TCG>TTG	p.S417L	uc002whv.1_Intron|UBOX5_uc002whx.2_Missense_Mutation_p.S417L|UBOX5_uc002why.1_Missense_Mutation_p.S417L	NM_014948	NP_055763	O94941	RNF37_HUMAN	U-box domain containing 5 isoform a	417						nucleus|ubiquitin ligase complex	ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|skin(1)	2						ATTACCTGTCGAGCAGTCCAT	0.527		NaN											0	0	0	0.001168	0	6	43									
POFUT1	23509	broad.mit.edu	37	20	30804435	30804435	+	Silent	SNP	C	C	T			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr20:30804435C>T	uc002wxp.2	+	4	502	c.453C>T	c.(451-453)TTC>TTT	p.F151F	POFUT1_uc002wxo.2_Silent_p.F151F|POFUT1_uc010ztt.1_Silent_p.F43F|POFUT1_uc010ztu.1_Intron	NM_015352	NP_056167	Q9H488	OFUT1_HUMAN	protein O-fucosyltransferase 1 isoform 1	151					fucose metabolic process|Notch signaling pathway|O-glycan processing|regulation of transcription, DNA-dependent	endoplasmic reticulum|membrane	peptide-O-fucosyltransferase activity			breast(1)	1			UCEC - Uterine corpus endometrioid carcinoma (5;0.0241)			TTGGCCCATTCTGGGATCAGT	0.507		NaN											0	0	0	0.010504	0	18	71									
EMILIN3	90187	broad.mit.edu	37	20	39990047	39990047	+	Missense_Mutation	SNP	C	C	A			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr20:39990047C>A	uc002xjy.1	-	4	2386	c.2162G>T	c.(2161-2163)AGA>ATA	p.R721I		NM_052846	NP_443078	Q9NT22	EMIL3_HUMAN	elastin microfibril interfacer 3	721						proteinaceous extracellular matrix				ovary(1)	1		Myeloproliferative disorder(115;0.00425)				CAGGCCCTCTCTGGGCCTCAG	0.672		NaN											1	0	4.3838e-07	0.016723	4.61085e-07	14	15									
PKIG	11142	broad.mit.edu	37	20	43246949	43246949	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr20:43246949C>G	uc002xmg.2	+	6	704	c.175C>G	c.(175-177)CCA>GCA	p.P59A	PKIG_uc002xmh.2_Missense_Mutation_p.P59A|PKIG_uc002xmi.2_Missense_Mutation_p.P59A	NM_181805	NP_861521	Q9Y2B9	IPKG_HUMAN	cAMP-dependent protein kinase inhibitor gamma	59							cAMP-dependent protein kinase inhibitor activity|protein binding				0		Myeloproliferative disorder(115;0.0122)	Colorectal(3;0.001)|COAD - Colon adenocarcinoma(18;0.00189)			GGGAAGCGCCCCAGACAAGGA	0.547		NaN											0	0	0	0.007291	0	29	152									
SNX21	90203	broad.mit.edu	37	20	44469809	44469809	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr20:44469809G>C	uc002xpv.1	+	4	1068	c.979G>C	c.(979-981)GAG>CAG	p.E327Q	SNX21_uc002xps.1_Intron|SNX21_uc002xpt.1_3'UTR|SNX21_uc002xpu.1_3'UTR|SNX21_uc002xpw.1_Missense_Mutation_p.E138Q|SNX21_uc002xpx.2_Missense_Mutation_p.E317Q|SNX21_uc010zxd.1_3'UTR|SNX21_uc002xpy.1_Missense_Mutation_p.E138Q|SNX21_uc002xpz.1_Missense_Mutation_p.E138Q	NM_033421	NP_219489	Q969T3	SNX21_HUMAN	sorting nexin 21 isoform a	327					cell communication|protein transport	cytoplasmic vesicle membrane	phosphatidylinositol binding			breast(1)|pancreas(1)	2		Myeloproliferative disorder(115;0.0122)				ACCCTTTCTGGAGGCCCATGT	0.657		NaN											0	0	0	0.010818	0	32	46									
SPATA2	9825	broad.mit.edu	37	20	48522407	48522407	+	Nonsense_Mutation	SNP	G	G	A	rs145093250		TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr20:48522407G>A	uc010gie.2	-	3	1662	c.1312C>T	c.(1312-1314)CAG>TAG	p.Q438*	SPATA2_uc002xuw.2_Nonsense_Mutation_p.Q438*|SPATA2_uc010zyn.1_Nonsense_Mutation_p.Q301*	NM_001135773	NP_001129245	Q9UM82	SPAT2_HUMAN	spermatogenesis associated 2	438					cell differentiation|multicellular organismal development|spermatogenesis	cytoplasm|nucleus				central_nervous_system(1)|skin(1)	2	Hepatocellular(150;0.133)		BRCA - Breast invasive adenocarcinoma(9;4.03e-06)			TCGAGGCCCTGAGTCTGGCCT	0.662		NaN											0	0	0	0.016723	0	14	52									
DIDO1	11083	broad.mit.edu	37	20	61511415	61511415	+	Nonsense_Mutation	SNP	G	G	A			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr20:61511415G>A	uc002ydr.1	-	16	6157	c.5893C>T	c.(5893-5895)CAG>TAG	p.Q1965*	DIDO1_uc002yds.1_Nonsense_Mutation_p.Q1965*	NM_033081	NP_149072	Q9BTC0	DIDO1_HUMAN	death inducer-obliterator 1 isoform c	1965	Pro-rich.				apoptosis|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			ovary(3)|skin(3)	6	Breast(26;5.68e-08)					TCGAACTGCTGAGGCTGAATG	0.577		NaN											0	0	0	0.01441	0	46	198									
DIDO1	11083	broad.mit.edu	37	20	61511882	61511882	+	Missense_Mutation	SNP	G	G	T			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr20:61511882G>T	uc002ydr.1	-	16	5690	c.5426C>A	c.(5425-5427)TCC>TAC	p.S1809Y	DIDO1_uc002yds.1_Missense_Mutation_p.S1809Y	NM_033081	NP_149072	Q9BTC0	DIDO1_HUMAN	death inducer-obliterator 1 isoform c	1809	Pro-rich.				apoptosis|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			ovary(3)|skin(3)	6	Breast(26;5.68e-08)					CGAGAATAAGGAAGGGATGGG	0.607		NaN											1	0	1.22574e-08	0.014323	1.31543e-08	20	97									
DIDO1	11083	broad.mit.edu	37	20	61512446	61512446	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr20:61512446G>A	uc002ydr.1	-	16	5126	c.4862C>T	c.(4861-4863)TCG>TTG	p.S1621L	DIDO1_uc002yds.1_Missense_Mutation_p.S1621L	NM_033081	NP_149072	Q9BTC0	DIDO1_HUMAN	death inducer-obliterator 1 isoform c	1621					apoptosis|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			ovary(3)|skin(3)	6	Breast(26;5.68e-08)					CTTTTCGCCCGAAGCCCAGGG	0.711		NaN											0	0	0	0.001984	0	7	8									
DIDO1	11083	broad.mit.edu	37	20	61512978	61512978	+	Silent	SNP	G	G	A			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr20:61512978G>A	uc002ydr.1	-	16	4594	c.4330C>T	c.(4330-4332)CTG>TTG	p.L1444L	DIDO1_uc002yds.1_Silent_p.L1444L	NM_033081	NP_149072	Q9BTC0	DIDO1_HUMAN	death inducer-obliterator 1 isoform c	1444					apoptosis|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			ovary(3)|skin(3)	6	Breast(26;5.68e-08)					CTGTTGGGCAGGTCATCAACA	0.617		NaN											0	0	0	0.009535	0	30	109									
DEPDC5	9681	broad.mit.edu	37	22	32174116	32174116	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr22:32174116G>A	uc003als.2	+	8	587	c.445G>A	c.(445-447)GAG>AAG	p.E149K	DEPDC5_uc011als.1_Missense_Mutation_p.E149K|DEPDC5_uc011alu.1_Missense_Mutation_p.E149K|DEPDC5_uc011alv.1_RNA|DEPDC5_uc003alt.2_Missense_Mutation_p.E149K|DEPDC5_uc003alr.1_Missense_Mutation_p.E149K|DEPDC5_uc011alt.1_Missense_Mutation_p.E121K	NM_014662	NP_055477	O75140	DEPD5_HUMAN	DEP domain containing 5 isoform 1	149					intracellular signal transduction					ovary(4)|central_nervous_system(3)|pancreas(1)	8						GGTTAAGAATGAGAAGGTCAT	0.333		NaN											0	0	0	0.010818	0	30	65									
MGAT3	4248	broad.mit.edu	37	22	39883792	39883792	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr22:39883792G>A	uc003axv.3	+	2	679	c.440G>A	c.(439-441)CGG>CAG	p.R147Q	MGAT3_uc010gxy.2_Missense_Mutation_p.R147Q	NM_002409	NP_002400	Q09327	MGAT3_HUMAN	mannosyl (beta-1,4-)-glycoprotein	147	Lumenal (Potential).				post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	beta-1,4-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity				0	Melanoma(58;0.04)					TCGGCCCGGCGGCCACCCCGG	0.766		NaN											0	0	0	0.004672	0	3	0									
SRGAP3	9901	broad.mit.edu	37	3	9146379	9146379	+	Silent	SNP	G	G	A			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr3:9146379G>A	uc003brf.1	-	3	1084	c.408C>T	c.(406-408)ATC>ATT	p.I136I	SRGAP3_uc003brg.1_Silent_p.I136I|SRGAP3_uc003bri.1_RNA|SRGAP3_uc003brk.2_Silent_p.I136I	NM_014850	NP_055665	O43295	SRGP2_HUMAN	SLIT-ROBO Rho GTPase activating protein 3	136					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|protein binding		SRGAP3/RAF1(4)	central_nervous_system(4)|skin(3)|urinary_tract(1)|breast(1)	9				OV - Ovarian serous cystadenocarcinoma(96;0.0563)		TGAAGAGTCTGATGACATCCT	0.552		NaN	T	RAF1	pilocytic astrocytoma								0	0	0	0.00632	0	28	65									
GALNTL2	117248	broad.mit.edu	37	3	16254202	16254202	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr3:16254202G>A	uc003car.3	+	6	1799	c.1324G>A	c.(1324-1326)GAG>AAG	p.E442K	GALNTL2_uc003caq.3_Missense_Mutation_p.E175K	NM_054110	NP_473451	Q8N3T1	GLTL2_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide	442	Lumenal (Potential).					Golgi membrane|integral to membrane|transport vesicle	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			breast(1)	1						TCGCATTGCTGAGACCTGGCT	0.547		NaN											0	0	0	0.003163	0	13	52									
EPM2AIP1	9852	broad.mit.edu	37	3	37033451	37033451	+	Nonsense_Mutation	SNP	G	G	C			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr3:37033451G>C	uc003cgk.2	-	1	1345	c.1118C>G	c.(1117-1119)TCA>TGA	p.S373*	MLH1_uc011aye.1_5'Flank|MLH1_uc003cgl.2_5'Flank|MLH1_uc011ayb.1_5'Flank|MLH1_uc010hge.2_5'Flank|MLH1_uc003cgn.3_5'Flank|MLH1_uc011ayc.1_5'Flank|MLH1_uc011ayd.1_5'Flank|MLH1_uc003cgo.2_5'Flank	NM_014805	NP_055620	Q7L775	EPMIP_HUMAN	EPM2A interacting protein 1	373						endoplasmic reticulum					0						TTGTTTGTCTGAGAAGTGGAC	0.398		NaN											0	0	0	0.01441	0	54	124									
NKTR	4820	broad.mit.edu	37	3	42680225	42680225	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr3:42680225G>A	uc003clo.2	+	13	3176	c.3029G>A	c.(3028-3030)CGA>CAA	p.R1010Q	NKTR_uc003clm.1_Missense_Mutation_p.R757Q|NKTR_uc003clp.2_Missense_Mutation_p.R757Q|NKTR_uc011azp.1_Intron|NKTR_uc003clq.1_Missense_Mutation_p.R900Q|NKTR_uc003clr.1_Missense_Mutation_p.R757Q|NKTR_uc003cls.2_Missense_Mutation_p.R710Q	NM_005385	NP_005376	P30414	NKTR_HUMAN	natural killer-tumor recognition sequence	1010	Arg/Lys-rich (basic).				protein folding	membrane	cyclosporin A binding|peptidyl-prolyl cis-trans isomerase activity			ovary(2)|skin(1)	3				KIRC - Kidney renal clear cell carcinoma(284;0.24)		GCTCCAAAACGAAAGCAAGCA	0.383		NaN											0	0	0	0.010729	0	10	42									
ZNF445	353274	broad.mit.edu	37	3	44497015	44497015	+	Silent	SNP	G	G	T			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr3:44497015G>T	uc003cnf.2	-	3	375	c.27C>A	c.(25-27)GCC>GCA	p.A9A	ZNF445_uc011azv.1_Silent_p.A9A|ZNF445_uc011azw.1_Silent_p.A9A	NM_181489	NP_852466	P59923	ZN445_HUMAN	zinc finger protein 445	9					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1				KIRC - Kidney renal clear cell carcinoma(197;0.0514)|Kidney(197;0.0646)		GAGCTGGATAGGCAGCATGCC	0.557		NaN											1	0	2.17888e-05	0.006214	2.24697e-05	10	47									
C3orf62	375341	broad.mit.edu	37	3	49308828	49308828	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr3:49308828C>G	uc003cwn.2	-	3	792	c.589G>C	c.(589-591)GAA>CAA	p.E197Q	C3orf62_uc003cwm.2_Missense_Mutation_p.E46Q|hsa-mir-4271|MI0015879_5'Flank	NM_198562	NP_940964	Q6ZUJ4	CC062_HUMAN	hypothetical protein LOC375341	197											0				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00218)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)		AATTCGTTTTCAAATTCTATT	0.423		NaN											0	0	0	0.008291	0	11	55									
AMIGO3	386724	broad.mit.edu	37	3	49756821	49756821	+	Missense_Mutation	SNP	G	G	T			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr3:49756821G>T	uc003cxj.2	-	1	418	c.78C>A	c.(76-78)TTC>TTA	p.F26L	RNF123_uc003cxh.2_Intron|RNF123_uc003cxi.2_Intron	NM_198722	NP_942015	Q86WK7	AMGO3_HUMAN	adhesion molecule with Ig-like domain 3	26	Extracellular (Potential).|LRRNT.				heterophilic cell-cell adhesion	integral to membrane				pancreas(1)	1				BRCA - Breast invasive adenocarcinoma(193;4.47e-05)|Kidney(197;0.00216)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)		CACGGGGCGGGAAACCCTCGG	0.642		NaN									OREG0015572	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	1	0	9.31168e-06	0.016723	9.64033e-06	13	37									
DOCK3	1795	broad.mit.edu	37	3	51317569	51317569	+	Silent	SNP	C	C	T			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr3:51317569C>T	uc011bds.1	+	27	2879	c.2856C>T	c.(2854-2856)CTC>CTT	p.L952L		NM_004947	NP_004938	Q8IZD9	DOCK3_HUMAN	dedicator of cytokinesis 3	952						cytoplasm	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity|SH3 domain binding				0				BRCA - Breast invasive adenocarcinoma(193;0.00105)|KIRC - Kidney renal clear cell carcinoma(197;0.00449)|Kidney(197;0.00518)		TCTCACTGCTCCGCCAGATGT	0.517		NaN											0	0	0	0.009096	0	3	25									
DNAH1	25981	broad.mit.edu	37	3	52398976	52398976	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr3:52398976G>A	uc011bef.1	+	34	5720	c.5459G>A	c.(5458-5460)GGC>GAC	p.G1820D		NM_015512	NP_056327	Q9P2D7	DYH1_HUMAN	dynein, axonemal, heavy chain 1	1820					ciliary or flagellar motility|microtubule-based movement|response to mechanical stimulus	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			large_intestine(3)	3				BRCA - Breast invasive adenocarcinoma(193;2.02e-05)|OV - Ovarian serous cystadenocarcinoma(275;0.000207)|Kidney(197;0.0022)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		ACGGACTACGGCATCCTGGAT	0.607		NaN											0	0	0	0.004007	0	14	63									
TFG	10342	broad.mit.edu	37	3	100467340	100467340	+	Nonsense_Mutation	SNP	C	C	T			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr3:100467340C>T	uc003due.2	+	8	1617	c.1168C>T	c.(1168-1170)CAG>TAG	p.Q390*	TFG_uc003duf.2_Nonsense_Mutation_p.Q390*|TFG_uc003dug.2_Nonsense_Mutation_p.Q386*|TFG_uc003duh.2_Nonsense_Mutation_p.Q386*|TFG_uc003dui.2_Nonsense_Mutation_p.Q390*	NM_006070	NP_006061	Q92734	TFG_HUMAN	TRK-fused	390					positive regulation of I-kappaB kinase/NF-kappaB cascade	cytoplasm	signal transducer activity		TFG/ALK(7)	haematopoietic_and_lymphoid_tissue(7)|lung(2)|large_intestine(1)|prostate(1)	11						TCCCTTTGGTCAGGGCTATAC	0.498		NaN	T	NTRK1|ALK	papillary thyroid|ALCL|NSCLC								0	0	0	0.013537	0	11	48									
CBLB	868	broad.mit.edu	37	3	105459361	105459361	+	Silent	SNP	C	C	G			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr3:105459361C>G	uc003dwc.2	-	7	1282	c.960G>C	c.(958-960)CTG>CTC	p.L320L	CBLB_uc011bhi.1_Silent_p.L342L|CBLB_uc003dwd.1_Silent_p.L320L|CBLB_uc003dwe.1_Silent_p.L320L|CBLB_uc011bhj.1_RNA	NM_170662	NP_733762	Q13191	CBLB_HUMAN	Cas-Br-M (murine) ecotropic retroviral	320	Cbl-PTB.|SH2-like.				cell surface receptor linked signaling pathway|NLS-bearing substrate import into nucleus	cytoplasm|nucleus	calcium ion binding|ligase activity|signal transducer activity|zinc ion binding			lung(4)|ovary(3)|breast(1)|skin(1)	9						TGCCATCAATCAGGGCTTGAA	0.418		NaN	Mis S		AML								0	0	0	0.012319	0	20	50									
DPPA4	55211	broad.mit.edu	37	3	109056349	109056349	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr3:109056349C>T	uc003dxq.3	-	1	71	c.16G>A	c.(16-18)GCT>ACT	p.A6T	DPPA4_uc011bho.1_Missense_Mutation_p.A6T|DPPA4_uc011bhp.1_Missense_Mutation_p.A6T	NM_018189	NP_060659	Q7L190	DPPA4_HUMAN	developmental pluripotency associated 4	6						nucleus	protein binding			upper_aerodigestive_tract(1)	1						GTAGAAGAAGCGGAGCCTCGC	0.493		NaN											0	0	0	0.004482	0	9	32									
POLQ	10721	broad.mit.edu	37	3	121228970	121228970	+	Nonsense_Mutation	SNP	G	G	A			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr3:121228970G>A	uc003eee.3	-	11	1861	c.1732C>T	c.(1732-1734)CAG>TAG	p.Q578*		NM_199420	NP_955452	O75417	DPOLQ_HUMAN	DNA polymerase theta	578					DNA repair|DNA replication	nucleoplasm	ATP binding|ATP-dependent helicase activity|damaged DNA binding|DNA-directed DNA polymerase activity|single-stranded DNA-dependent ATPase activity			ovary(4)|breast(3)|lung(2)|upper_aerodigestive_tract(1)|skin(1)	11				GBM - Glioblastoma multiforme(114;0.0915)		GCTCCAAGCTGAACAGACTCT	0.428		NaN						DNA_polymerases_(catalytic_subunits)					0	0	0	0.012319	0	23	62									
PLCH1	23007	broad.mit.edu	37	3	155199036	155199036	+	Silent	SNP	C	C	T			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr3:155199036C>T	uc011bok.1	-	23	5080	c.4803G>A	c.(4801-4803)AAG>AAA	p.K1601K	PLCH1_uc011boj.1_3'UTR|PLCH1_uc011bol.1_Silent_p.K1563K	NM_001130960	NP_001124432	Q4KWH8	PLCH1_HUMAN	phospholipase C eta 1 isoform a	1601					lipid catabolic process|phosphatidylinositol-mediated signaling	membrane	calcium ion binding|calcium-dependent phospholipase C activity|phosphatidylinositol phospholipase C activity|signal transducer activity			skin(3)|ovary(1)	4			Lung(72;0.11)|LUSC - Lung squamous cell carcinoma(72;0.114)			GAACTTTCTGCTTGTTGGCTT	0.547		NaN											0	0	0	0.004656	0	28	52									
PLCH1	23007	broad.mit.edu	37	3	155199541	155199541	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr3:155199541G>C	uc011bok.1	-	23	4575	c.4298C>G	c.(4297-4299)TCT>TGT	p.S1433C	PLCH1_uc011boj.1_3'UTR|PLCH1_uc011bol.1_Missense_Mutation_p.S1395C	NM_001130960	NP_001124432	Q4KWH8	PLCH1_HUMAN	phospholipase C eta 1 isoform a	1433					lipid catabolic process|phosphatidylinositol-mediated signaling	membrane	calcium ion binding|calcium-dependent phospholipase C activity|phosphatidylinositol phospholipase C activity|signal transducer activity			skin(3)|ovary(1)	4			Lung(72;0.11)|LUSC - Lung squamous cell carcinoma(72;0.114)			GGCTAGATAAGAAATACTTTG	0.413		NaN											0	0	0	0.004656	0	28	46									
ACTL6A	86	broad.mit.edu	37	3	179294032	179294032	+	Silent	SNP	G	G	A			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr3:179294032G>A	uc003fjw.2	+	6	677	c.504G>A	c.(502-504)CTG>CTA	p.L168L	ACTL6A_uc003fjx.2_Silent_p.L126L|ACTL6A_uc003fjy.2_Silent_p.L126L	NM_004301	NP_004292	O96019	ACL6A_HUMAN	actin-like 6A isoform 1	168					chromatin remodeling|DNA recombination|DNA repair|histone H2A acetylation|histone H4 acetylation|nervous system development|regulation of growth|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	Ino80 complex|npBAF complex|NuA4 histone acetyltransferase complex|plasma membrane|SWI/SNF complex	ATP binding|chromatin binding			ovary(1)	1	all_cancers(143;3.94e-16)|Ovarian(172;0.0172)|Breast(254;0.191)		OV - Ovarian serous cystadenocarcinoma(80;5.98e-26)|GBM - Glioblastoma multiforme(14;0.0169)			CTACTGGGCTGATTTTGGACA	0.398		NaN											0	0	0	0.004007	0	13	26									
ACTL6A	86	broad.mit.edu	37	3	179294656	179294656	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr3:179294656G>C	uc003fjw.2	+	8	896	c.723G>C	c.(721-723)GAG>GAC	p.E241D	ACTL6A_uc003fjx.2_Missense_Mutation_p.E199D|ACTL6A_uc003fjy.2_Missense_Mutation_p.E199D	NM_004301	NP_004292	O96019	ACL6A_HUMAN	actin-like 6A isoform 1	241					chromatin remodeling|DNA recombination|DNA repair|histone H2A acetylation|histone H4 acetylation|nervous system development|regulation of growth|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	Ino80 complex|npBAF complex|NuA4 histone acetyltransferase complex|plasma membrane|SWI/SNF complex	ATP binding|chromatin binding			ovary(1)	1	all_cancers(143;3.94e-16)|Ovarian(172;0.0172)|Breast(254;0.191)		OV - Ovarian serous cystadenocarcinoma(80;5.98e-26)|GBM - Glioblastoma multiforme(14;0.0169)			AAAGAAAAGAGAAGTTGCCTC	0.418		NaN											0	0	0	0.00632	0	28	54									
RTP1	132112	broad.mit.edu	37	3	186917517	186917517	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr3:186917517G>A	uc003frg.2	+	2	481	c.451G>A	c.(451-453)GAG>AAG	p.E151K		NM_153708	NP_714919	P59025	RTP1_HUMAN	receptor transporting protein 1	151	Cytoplasmic (Potential).				protein insertion into membrane	cell surface|integral to membrane|plasma membrane	olfactory receptor binding			ovary(2)|breast(1)	3	all_cancers(143;5.33e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;5.56e-18)	GBM - Glioblastoma multiforme(93;0.0269)		GGAGAACATCGAGGGCCTGGT	0.682		NaN											0	0	0	0.014758	0	5	31									
SH3TC1	54436	broad.mit.edu	37	4	8214432	8214432	+	Silent	SNP	G	G	C			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr4:8214432G>C	uc003gkv.3	+	4	353	c.252G>C	c.(250-252)CTG>CTC	p.L84L	SH3TC1_uc003gkw.3_Silent_p.L8L|SH3TC1_uc003gkx.3_RNA	NM_018986	NP_061859	Q8TE82	S3TC1_HUMAN	SH3 domain and tetratricopeptide repeats 1	84							binding			large_intestine(2)|pancreas(1)	3						CTCCAGACCTGACCCTGCAGC	0.662		NaN											0	0	0	0.001984	0	7	23									
LIN54	132660	broad.mit.edu	37	4	83858433	83858433	+	Silent	SNP	C	C	G			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr4:83858433C>G	uc003hnx.3	-	9	1929	c.1551G>C	c.(1549-1551)TCG>TCC	p.S517S	LIN54_uc003hnz.3_Silent_p.S296S|LIN54_uc003hny.3_Silent_p.S116S|LIN54_uc010ijt.2_Silent_p.S428S|LIN54_uc010iju.2_Silent_p.S116S|LIN54_uc010ijv.2_Silent_p.S296S	NM_194282	NP_919258	Q6MZP7	LIN54_HUMAN	lin-54 homolog isoform a	517					cell cycle|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding				0		Hepatocellular(203;0.114)				GCCGACTGGCCGACTCTGATG	0.303		NaN											0	0	0	0.006214	0	10	69									
GPRIN3	285513	broad.mit.edu	37	4	90170794	90170794	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr4:90170794C>T	uc003hsm.1	-	2	987	c.468G>A	c.(466-468)ATG>ATA	p.M156I		NM_198281	NP_938022	Q6ZVF9	GRIN3_HUMAN	G protein-regulated inducer of neurite outgrowth	156										ovary(3)	3		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;5.67e-05)		TCTGTGATCTCATCAGGGAAT	0.517		NaN											0	0	0	0.004656	0	28	63									
LEF1	51176	broad.mit.edu	37	4	108999479	108999479	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr4:108999479G>A	uc003hyt.1	-	8	1560	c.905C>T	c.(904-906)CCT>CTT	p.P302L	LEF1_uc011cfj.1_Missense_Mutation_p.P159L|LEF1_uc011cfk.1_Missense_Mutation_p.P206L|LEF1_uc003hyu.1_Missense_Mutation_p.P274L|LEF1_uc003hyv.1_Missense_Mutation_p.P274L|LEF1_uc010imb.1_RNA|LEF1_uc010ima.1_5'UTR|LEF1_uc003hyw.1_RNA	NM_016269	NP_057353	Q9UJU2	LEF1_HUMAN	lymphoid enhancer-binding factor 1 isoform 1	302	HMG box.				canonical Wnt receptor signaling pathway|cell chemotaxis|cellular response to interleukin-4|epithelial to mesenchymal transition|histone H3 acetylation|histone H4 acetylation|negative regulation of apoptosis in bone marrow|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cell-cell adhesion|negative regulation of DNA binding|negative regulation of estrogen receptor binding|negative regulation of interleukin-13 production|negative regulation of interleukin-4 production|negative regulation of interleukin-5 production|negative regulation of transcription, DNA-dependent|neutrophil differentiation|osteoblast differentiation|palate development|positive regulation by host of viral transcription|positive regulation of cell cycle process|positive regulation of cell growth|positive regulation of cell migration|positive regulation of cell migration|positive regulation of cell proliferation|positive regulation of cell proliferation in bone marrow|positive regulation of cell-cell adhesion|positive regulation of epithelial to mesenchymal transition|positive regulation of granulocyte differentiation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|T-helper 1 cell differentiation	cytoplasm|protein-DNA complex|transcription factor complex	armadillo repeat domain binding|beta-catenin binding|C2H2 zinc finger domain binding|caspase inhibitor activity|DNA bending activity|enhancer binding|estrogen receptor activity|estrogen receptor binding|gamma-catenin binding|histone binding|sequence-specific DNA binding|transcription regulatory region DNA binding			large_intestine(1)	1				OV - Ovarian serous cystadenocarcinoma(123;0.000224)		AGCATTCAGAGGCTTCTTAAT	0.443		NaN											0	0	0	0.01441	0	72	166									
LEF1	51176	broad.mit.edu	37	4	109084785	109084785	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr4:109084785G>C	uc003hyt.1	-	3	1008	c.353C>G	c.(352-354)CCA>CGA	p.P118R	LEF1_uc011cfj.1_Missense_Mutation_p.P3R|LEF1_uc011cfk.1_Missense_Mutation_p.P50R|LEF1_uc003hyu.1_Missense_Mutation_p.P118R|LEF1_uc003hyv.1_Missense_Mutation_p.P118R|LEF1_uc010imb.1_RNA	NM_016269	NP_057353	Q9UJU2	LEF1_HUMAN	lymphoid enhancer-binding factor 1 isoform 1	118	Pro-rich.				canonical Wnt receptor signaling pathway|cell chemotaxis|cellular response to interleukin-4|epithelial to mesenchymal transition|histone H3 acetylation|histone H4 acetylation|negative regulation of apoptosis in bone marrow|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cell-cell adhesion|negative regulation of DNA binding|negative regulation of estrogen receptor binding|negative regulation of interleukin-13 production|negative regulation of interleukin-4 production|negative regulation of interleukin-5 production|negative regulation of transcription, DNA-dependent|neutrophil differentiation|osteoblast differentiation|palate development|positive regulation by host of viral transcription|positive regulation of cell cycle process|positive regulation of cell growth|positive regulation of cell migration|positive regulation of cell migration|positive regulation of cell proliferation|positive regulation of cell proliferation in bone marrow|positive regulation of cell-cell adhesion|positive regulation of epithelial to mesenchymal transition|positive regulation of granulocyte differentiation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|T-helper 1 cell differentiation	cytoplasm|protein-DNA complex|transcription factor complex	armadillo repeat domain binding|beta-catenin binding|C2H2 zinc finger domain binding|caspase inhibitor activity|DNA bending activity|enhancer binding|estrogen receptor activity|estrogen receptor binding|gamma-catenin binding|histone binding|sequence-specific DNA binding|transcription regulatory region DNA binding			large_intestine(1)	1				OV - Ovarian serous cystadenocarcinoma(123;0.000224)		ATTCATATTTGGCATCATTAT	0.428		NaN											0	0	0	0.012319	0	22	70									
ANP32C	23520	broad.mit.edu	37	4	165118848	165118848	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr4:165118848G>A	uc011cjk.1	-	1	16	c.16C>T	c.(16-18)CGG>TGG	p.R6W	MARCH1_uc003iqs.1_Intron	NM_012403	NP_036535	O43423	AN32C_HUMAN	acidic nuclear phosphoprotein 32C	6											0	all_hematologic(180;0.203)	Prostate(90;0.0138)|Melanoma(52;0.18)|all_neural(102;0.223)		KIRC - Kidney renal clear cell carcinoma(143;0.242)		GAATGAATCCGTCTGCCCATC	0.552		NaN											0	0	0	0.006999	0	38	87									
SLC6A19	340024	broad.mit.edu	37	5	1219057	1219057	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr5:1219057G>A	uc003jbw.3	+	9	1269	c.1213G>A	c.(1213-1215)GAG>AAG	p.E405K		NM_001003841	NP_001003841	Q695T7	S6A19_HUMAN	solute carrier family 6, member 19	405	Extracellular (Potential).				cellular nitrogen compound metabolic process	integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity				0	all_cancers(3;3.55e-15)|Lung NSC(6;2.89e-14)|all_lung(6;2.2e-13)|all_epithelial(6;3.75e-10)		Epithelial(17;0.000356)|all cancers(22;0.00137)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|Lung(60;0.185)			CGTCTTCACCGAGGCCATCAC	0.607		NaN											0	0	0	0.008871	0	19	36									
CTNND2	1501	broad.mit.edu	37	5	11117566	11117566	+	Missense_Mutation	SNP	C	C	A			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr5:11117566C>A	uc003jfa.1	-	13	2418	c.2273G>T	c.(2272-2274)AGC>ATC	p.S758I	CTNND2_uc010itt.2_Missense_Mutation_p.S667I|CTNND2_uc011cmy.1_Missense_Mutation_p.S421I|CTNND2_uc011cmz.1_Missense_Mutation_p.S325I|CTNND2_uc010itu.1_RNA|CTNND2_uc011cmx.1_Missense_Mutation_p.S325I	NM_001332	NP_001323	Q9UQB3	CTND2_HUMAN	catenin (cadherin-associated protein), delta 2	758	ARM 6.				multicellular organismal development|neuron cell-cell adhesion|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	adherens junction|cytoplasm|nucleus	protein binding			large_intestine(2)|ovary(2)|skin(2)|pancreas(1)|lung(1)	8						ACCAACCTTGCTATCGATCTC	0.512		NaN											1	0	2.12542e-12	0.00632	2.29963e-12	29	87									
ADAMTS12	81792	broad.mit.edu	37	5	33588796	33588796	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr5:33588796C>T	uc003jia.1	-	18	2936	c.2773G>A	c.(2773-2775)GAC>AAC	p.D925N	ADAMTS12_uc010iuq.1_Missense_Mutation_p.D840N	NM_030955	NP_112217	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1	925	TSP type-1 3.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|kidney(1)	9						TGCTGGCAGTCTGTGGGCGGG	0.627		NaN								HNSCC(64;0.19)			0	0	0	0.00632	0	29	77									
RICTOR	253260	broad.mit.edu	37	5	38955780	38955780	+	Silent	SNP	C	C	T			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr5:38955780C>T	uc003jlp.2	-	26	2550	c.2526G>A	c.(2524-2526)TTG>TTA	p.L842L	RICTOR_uc003jlo.2_Silent_p.L842L|RICTOR_uc010ivf.2_Silent_p.L557L	NM_152756	NP_689969	Q6R327	RICTR_HUMAN	rapamycin-insensitive companion of mTOR	842					actin cytoskeleton reorganization|embryo development|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of TOR signaling cascade|regulation of protein kinase B signaling cascade|T cell costimulation	cytosol|TORC2 complex	protein binding			ovary(3)|lung(3)|skin(2)|kidney(1)|central_nervous_system(1)	10	all_lung(31;0.000396)					GTTCCTCAATCAAGTCAACAT	0.358		NaN											0	0	0	0.013537	0	12	54									
PDE4D	5144	broad.mit.edu	37	5	58270810	58270810	+	Missense_Mutation	SNP	T	T	C			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr5:58270810T>C	uc003jsa.2	-	15	2283	c.2111A>G	c.(2110-2112)AAT>AGT	p.N704S	PDE4D_uc003jrx.2_Missense_Mutation_p.N568S|PDE4D_uc003jry.2_Missense_Mutation_p.N402S|PDE4D_uc003jrz.2_Missense_Mutation_p.N640S|PDE4D_uc003jsb.2_Missense_Mutation_p.N643S|PDE4D_uc003jrt.2_Missense_Mutation_p.N402S|PDE4D_uc003jru.2_Missense_Mutation_p.N480S|PDE4D_uc003jrv.2_Missense_Mutation_p.N574S|PDE4D_uc003jrw.2_Missense_Mutation_p.N582S|PDE4D_uc003jrs.2_Missense_Mutation_p.N413S	NM_001104631	NP_001098101	Q08499	PDE4D_HUMAN	phosphodiesterase 4D isoform 1	704					signal transduction	cytosol|insoluble fraction|membrane|microtubule organizing center|soluble fraction	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding			breast(1)|central_nervous_system(1)	2		all_cancers(5;6.5e-58)|all_epithelial(5;1.75e-57)|all_lung(5;6.84e-18)|Lung NSC(5;1.29e-17)|Melanoma(5;0.00168)|Prostate(74;0.00234)|Colorectal(97;0.00629)|Ovarian(174;0.00832)|Breast(144;0.00996)|all_hematologic(6;0.0344)|Hepatocellular(6;0.0742)|Esophageal squamous(6;0.0954)		Epithelial(2;2.6e-55)|all cancers(2;2.66e-49)|OV - Ovarian serous cystadenocarcinoma(10;1.48e-39)|Colorectal(2;8.29e-08)|Lung(2;4.47e-07)|STAD - Stomach adenocarcinoma(2;1.11e-05)|COAD - Colon adenocarcinoma(2;0.00012)|LUSC - Lung squamous cell carcinoma(2;0.000775)|LUAD - Lung adenocarcinoma(3;0.0173)|READ - Rectum adenocarcinoma(2;0.0276)	Adenosine monophosphate(DB00131)|Dyphylline(DB00651)	CCATTCACGATTGTCCTCCAA	0.532		NaN											0	0	0	0.00308	0	8	27									
FER	2241	broad.mit.edu	37	5	108290634	108290634	+	Splice_Site	SNP	G	G	A			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr5:108290634G>A	uc003kop.1	+	12	1917	c.1533_splice	c.e12+1	p.D511_splice	FER_uc011cvf.1_Intron|FER_uc011cvg.1_Splice_Site_p.D336_splice	NM_005246	NP_005237	P16591	FER_HUMAN	fer (fps/fes related) tyrosine kinase						intracellular signal transduction|peptidyl-tyrosine phosphorylation	cytoplasm|nucleus	ATP binding|non-membrane spanning protein tyrosine kinase activity			lung(2)|stomach(1)|ovary(1)|kidney(1)	5		all_cancers(142;2.86e-06)|all_epithelial(76;9.81e-08)|Prostate(80;0.00972)|Lung NSC(167;0.039)|Ovarian(225;0.0448)|all_lung(232;0.0496)|Colorectal(57;0.0986)|Breast(839;0.152)		OV - Ovarian serous cystadenocarcinoma(64;6.77e-10)|Epithelial(69;4.13e-08)|COAD - Colon adenocarcinoma(37;0.0174)		ATATGTTGATGTACGTTTCCA	0.343		NaN											0	0	0	0.021523	0	24	48									
PCDHB1	29930	broad.mit.edu	37	5	140432632	140432632	+	Missense_Mutation	SNP	A	A	G			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr5:140432632A>G	uc003lik.1	+	1	1654	c.1577A>G	c.(1576-1578)CAA>CGA	p.Q526R		NM_013340	NP_037472	Q9Y5F3	PCDB1_HUMAN	protocadherin beta 1 precursor	526	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GAGGCCATTCAAGATTTTCAA	0.438		NaN											0	0	0	0.010729	0	12	39									
PCDHGA11	56105	broad.mit.edu	37	5	140801665	140801665	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr5:140801665G>A	uc003lkq.1	+	1	1129	c.871G>A	c.(871-873)GAA>AAA	p.E291K	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc003lkh.1_Intron|PCDHGB6_uc003lkj.1_Intron|PCDHGA10_uc003lkl.1_Intron|PCDHGB7_uc003lkn.1_Intron|PCDHGA11_uc003lko.1_Missense_Mutation_p.E291K|PCDHGA11_uc003lkp.1_Missense_Mutation_p.E291K	NM_018914	NP_061737	Q9Y5H2	PCDGB_HUMAN	protocadherin gamma subfamily A, 11 isoform 1	291	Extracellular (Potential).|Cadherin 3.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CAAGGCTTCTGAAATATTCCA	0.428		NaN											0	0	0	0.010771	0	38	92									
DIAPH1	1729	broad.mit.edu	37	5	140960344	140960344	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr5:140960344G>C	uc003llb.3	-	8	932	c.791C>G	c.(790-792)TCT>TGT	p.S264C	DIAPH1_uc003llc.3_Missense_Mutation_p.S255C	NM_005219	NP_005210	O60610	DIAP1_HUMAN	diaphanous 1 isoform 1	264	GBD/FH3.				regulation of microtubule-based process|sensory perception of sound	cytoplasm|cytoskeleton|ruffle membrane	actin binding|receptor binding|Rho GTPase binding			skin(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ACAAAGAGCAGAAAGCAGCTT	0.418		NaN											0	0	0	0.003163	0	15	55									
RARS	5917	broad.mit.edu	37	5	167933745	167933745	+	Missense_Mutation	SNP	A	A	G			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr5:167933745A>G	uc003lzx.2	+	11	1296	c.1255A>G	c.(1255-1257)ATA>GTA	p.I419V	RARS_uc011deo.1_Missense_Mutation_p.I213V	NM_002887	NP_002878	P54136	SYRC_HUMAN	arginyl-tRNA synthetase	419					arginyl-tRNA aminoacylation	cytosol|nucleus|soluble fraction	arginine-tRNA ligase activity|ATP binding|protein binding			ovary(2)|skin(1)	3	Renal(175;0.000159)|Lung NSC(126;0.0875)|all_lung(126;0.166)	Medulloblastoma(196;0.0208)|all_neural(177;0.0227)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0693)|Epithelial(171;0.131)|OV - Ovarian serous cystadenocarcinoma(192;0.156)		CTTCCAGACAATATTTGCTGC	0.398		NaN											0	0	0	0.01892	0	24	30									
SH3PXD2B	285590	broad.mit.edu	37	5	171773245	171773245	+	Silent	SNP	C	C	T			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr5:171773245C>T	uc003mbr.2	-	12	1254	c.1083G>A	c.(1081-1083)CCG>CCA	p.P361P		NM_001017995	NP_001017995	A1X283	SPD2B_HUMAN	SH3 and PX domains 2B	361					adipose tissue development|bone development|cell communication|cell differentiation|eye development|heart development|podosome assembly	cell junction|cell projection|cytoplasm|podosome	phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-5-phosphate binding|SH2 domain binding			ovary(3)|skin(1)	4	Renal(175;0.000159)|Lung NSC(126;0.011)|all_lung(126;0.0175)	Medulloblastoma(196;0.0207)|all_neural(177;0.0625)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			TGGGCGGCTTCGGCAGGTTGA	0.597		NaN											0	0	0	0.019004	0	34	68									
NHLRC1	378884	broad.mit.edu	37	6	18122075	18122075	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr6:18122075C>T	uc003ncl.1	-	1	777	c.763G>A	c.(763-765)GAA>AAA	p.E255K		NM_198586	NP_940988	Q6VVB1	NHLC1_HUMAN	NHL repeat containing 1	255	NHL 4.				proteasomal ubiquitin-dependent protein catabolic process|protein polyubiquitination	endoplasmic reticulum|nucleus	protein binding|ubiquitin-protein ligase activity|zinc ion binding				0	Ovarian(93;0.016)|Breast(50;0.0245)	all_hematologic(90;0.165)	all cancers(50;0.0451)|Epithelial(50;0.0493)			TGCAACCTTTCAGTTCTCCGA	0.632		NaN											0	0	0	0.006214	0	9	23									
SCAND3	114821	broad.mit.edu	37	6	28542657	28542657	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr6:28542657C>G	uc003nlo.2	-	3	2443	c.1825G>C	c.(1825-1827)GAA>CAA	p.E609Q		NM_052923	NP_443155	Q6R2W3	SCND3_HUMAN	SCAN domain containing 3	609					DNA integration|viral reproduction	nucleus	DNA binding|protein dimerization activity|sequence-specific DNA binding transcription factor activity			ovary(1)	1						CCTGTGCATTCTTTTTCACAA	0.413		NaN											0	0	0	0.006214	0	10	18									
TNXB	7148	broad.mit.edu	37	6	32014154	32014155	+	Nonsense_Mutation	DNP	GG	GG	TT			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr6:32014154_32014155GG>TT	uc003nzl.2	-	31	10599_10600	c.10397_10398CC>AA	c.(10396-10398)TCC>TAA	p.S3466*	TNXB_uc003nzg.1_5'Flank|TNXB_uc003nzh.1_Translation_Start_Site	NM_019105	NP_061978	P22105	TENX_HUMAN	tenascin XB isoform 1 precursor	3513	Fibronectin type-III 27.				actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding				0						CTACCGTCCAGGACAGGCGCAG	0.663		NaN											0	0	0	0.004672	0	16	23									
FKBP5	2289	broad.mit.edu	37	6	35543683	35543683	+	Nonsense_Mutation	SNP	C	C	A			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr6:35543683C>A	uc011dte.1	-	11	1506	c.1303G>T	c.(1303-1305)GAA>TAA	p.E435*	FKBP5_uc003okx.2_Nonsense_Mutation_p.E435*|FKBP5_uc011dtf.1_Nonsense_Mutation_p.E256*|FKBP5_uc003oky.2_Nonsense_Mutation_p.E435*	NM_001145776	NP_001139248	Q13451	FKBP5_HUMAN	FK506 binding protein 5 isoform 1	435					protein folding	cytoplasm|membrane|nucleus	FK506 binding|heat shock protein binding|peptidyl-prolyl cis-trans isomerase activity			ovary(1)	1						GTGACCCCTTCTGAAGTCTTC	0.448		NaN											1	0	1.86633e-21	0.01441	2.036e-21	48	160									
LRFN2	57497	broad.mit.edu	37	6	40360393	40360393	+	Silent	SNP	G	G	A			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr6:40360393G>A	uc003oph.1	-	3	2124	c.1659C>T	c.(1657-1659)CTC>CTT	p.L553L		NM_020737	NP_065788	Q9ULH4	LRFN2_HUMAN	leucine rich repeat and fibronectin type III	553	Helical; (Potential).					cell junction|integral to membrane|postsynaptic membrane				ovary(2)|skin(1)	3	Ovarian(28;0.0418)|Colorectal(47;0.196)					AGCGCACCATGAGGATGACGA	0.632		NaN											0	0	0	0.008291	0	11	22									
TRERF1	55809	broad.mit.edu	37	6	42224510	42224510	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr6:42224510C>T	uc003osd.2	-	12	3099	c.2536G>A	c.(2536-2538)GAA>AAA	p.E846K	TRERF1_uc011duq.1_Missense_Mutation_p.E763K|TRERF1_uc003osb.2_Missense_Mutation_p.E602K|TRERF1_uc003osc.2_Missense_Mutation_p.E602K|TRERF1_uc003ose.2_Missense_Mutation_p.E866K	NM_033502	NP_277037	Q96PN7	TREF1_HUMAN	transcriptional regulating factor 1	846	ELM2.|Interacts with CREBBP.				cholesterol catabolic process|homeostatic process|multicellular organismal development|positive regulation of transcription, DNA-dependent|regulation of hormone biosynthetic process|steroid biosynthetic process	nucleus	DNA bending activity|ligand-dependent nuclear receptor transcription coactivator activity|RNA polymerase II transcription cofactor activity|sequence-specific DNA binding transcription factor activity|transcription factor binding|zinc ion binding			ovary(3)|pancreas(1)|skin(1)	5	Colorectal(47;0.196)		Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)			AAAGCAAATTCAGAATTGGTC	0.438		NaN											0	0	0	0.00499	0	15	43									
PKHD1	5314	broad.mit.edu	37	6	51768474	51768474	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr6:51768474G>A	uc003pah.1	-	43	7193	c.6917C>T	c.(6916-6918)TCT>TTT	p.S2306F	PKHD1_uc010jzn.1_Missense_Mutation_p.S289F|PKHD1_uc003pai.2_Missense_Mutation_p.S2306F	NM_138694	NP_619639	P08F94	PKHD1_HUMAN	fibrocystin isoform 1	2306	PbH1 3.|Extracellular (Potential).				cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			lung(15)|ovary(15)|large_intestine(5)|central_nervous_system(3)|skin(3)|breast(2)|upper_aerodigestive_tract(1)	44	Lung NSC(77;0.0605)					CTCGGCACCAGAAACCTGGAT	0.413		NaN											0	0	0	0.016522	0	23	67									
BACH2	60468	broad.mit.edu	37	6	90642373	90642373	+	Silent	SNP	G	G	A			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr6:90642373G>A	uc011eab.1	-	9	3089	c.2280C>T	c.(2278-2280)TGC>TGT	p.C760C	BACH2_uc003pnw.2_Silent_p.C760C	NM_021813	NP_068585	Q9BYV9	BACH2_HUMAN	BTB and CNC homology 1, basic leucine zipper	760						nucleus	protein dimerization activity|sequence-specific DNA binding			ovary(3)|pancreas(1)|lung(1)|skin(1)	6		all_cancers(76;7.37e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.0063)		BRCA - Breast invasive adenocarcinoma(108;0.0799)		CCCCCACTGCGCATTGGGAGG	0.637		NaN											0	0	0	0.013537	0	11	34									
RBM16	22828	broad.mit.edu	37	6	155153375	155153375	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr6:155153375C>G	uc003qqa.2	+	21	2894	c.2662C>G	c.(2662-2664)CCA>GCA	p.P888A	TIAM2_uc003qqb.2_5'Flank|RBM16_uc011efj.1_Missense_Mutation_p.P954A|RBM16_uc011efk.1_Missense_Mutation_p.P933A|RBM16_uc003qpz.2_Missense_Mutation_p.P888A|RBM16_uc010kji.2_Intron	NM_014892	NP_055707	Q9UPN6	SCAF8_HUMAN	RNA-binding motif protein 16	888	Pro-rich.				mRNA processing|RNA splicing	nuclear matrix|spliceosomal complex	nucleotide binding|RNA binding|RNA polymerase core enzyme binding				0		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;2.33e-15)|BRCA - Breast invasive adenocarcinoma(81;0.00524)		AGTACAGCCACCAAATGTTCC	0.458		NaN											0	0	0	0.010818	0	33	42									
RBM16	22828	broad.mit.edu	37	6	155153393	155153393	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr6:155153393C>G	uc003qqa.2	+	21	2912	c.2680C>G	c.(2680-2682)CCT>GCT	p.P894A	TIAM2_uc003qqb.2_5'Flank|RBM16_uc011efj.1_Missense_Mutation_p.P960A|RBM16_uc011efk.1_Missense_Mutation_p.P939A|RBM16_uc003qpz.2_Missense_Mutation_p.P894A|RBM16_uc010kji.2_Intron	NM_014892	NP_055707	Q9UPN6	SCAF8_HUMAN	RNA-binding motif protein 16	894	Pro-rich.				mRNA processing|RNA splicing	nuclear matrix|spliceosomal complex	nucleotide binding|RNA binding|RNA polymerase core enzyme binding				0		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;2.33e-15)|BRCA - Breast invasive adenocarcinoma(81;0.00524)		TCCAAATACTCCTGGACTTCT	0.453		NaN											0	0	0	0.013726	0	34	47									
MIOS	54468	broad.mit.edu	37	7	7612191	7612191	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr7:7612191C>G	uc003srf.2	+	4	393	c.85C>G	c.(85-87)CAT>GAT	p.H29D	MIOS_uc010ktp.1_Missense_Mutation_p.H29D	NM_019005	NP_061878	Q9NXC5	MIO_HUMAN	missing oocyte, meiosis regulator, homolog	29											0						AAGTCTTTATCATGTGGAATC	0.383		NaN											0	0	0	0.004482	0	9	28									
GLI3	2737	broad.mit.edu	37	7	42005908	42005908	+	Silent	SNP	G	G	A			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr7:42005908G>A	uc011kbh.1	-	15	2854	c.2763C>T	c.(2761-2763)CTC>CTT	p.L921L	GLI3_uc011kbg.1_Silent_p.L862L	NM_000168	NP_000159	P10071	GLI3_HUMAN	GLI-Kruppel family member GLI3	921					negative regulation of alpha-beta T cell differentiation|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of smoothened signaling pathway|negative regulation of transcription from RNA polymerase II promoter|negative thymic T cell selection|positive regulation of alpha-beta T cell differentiation|positive regulation of transcription from RNA polymerase II promoter|thymocyte apoptosis	cilium|cytosol|nucleolus	beta-catenin binding|histone acetyltransferase binding|histone deacetylase binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(11)|ovary(3)|large_intestine(2)|central_nervous_system(1)|kidney(1)|pancreas(1)	19						GGGCGGGCGTGAGGCTGAGCA	0.701		NaN							Greig_Cephalopolysyndactyly|Pallister-Hall_syndrome				0	0	0	0.006214	0	9	23									
ASL	435	broad.mit.edu	37	7	65553815	65553815	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr7:65553815C>T	uc003tuo.2	+	11	851	c.740C>T	c.(739-741)TCG>TTG	p.S247L	ASL_uc003tup.2_Missense_Mutation_p.S247L|ASL_uc003tur.2_Missense_Mutation_p.S221L|ASL_uc003tuq.2_Missense_Mutation_p.S247L	NM_000048	NP_000039	P04424	ARLY_HUMAN	argininosuccinate lyase isoform 1	247					arginine biosynthetic process via ornithine|arginine catabolic process|urea cycle	cytosol	argininosuccinate lyase activity			breast(2)	2					L-Arginine(DB00125)	TTCTGGGCTTCGCTGTGCATG	0.587		NaN											0	0	0	0.004482	0	8	34									
FZD9	8326	broad.mit.edu	37	7	72849364	72849364	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr7:72849364G>A	uc003tyb.2	+	1	1256	c.1027G>A	c.(1027-1029)GGG>AGG	p.G343R		NM_003508	NP_003499	O00144	FZD9_HUMAN	frizzled 9 precursor	343	Cytoplasmic (Potential).				B cell differentiation|brain development|canonical Wnt receptor signaling pathway|embryo development|gonad development|neuroblast proliferation|vasculature development	cell surface|filopodium membrane|integral to membrane|perinuclear region of cytoplasm	G-protein coupled receptor activity|PDZ domain binding|protein heterodimerization activity|protein homodimerization activity|Wnt receptor activity|Wnt-protein binding			central_nervous_system(1)	1		Lung NSC(55;0.0659)|all_lung(88;0.152)				CCTGGCTGCCGGGAAGAAATG	0.637		NaN											0	0	0	0.006214	0	10	47									
CLIP2	7461	broad.mit.edu	37	7	73771712	73771712	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr7:73771712G>A	uc003uam.2	+	6	1447	c.1120G>A	c.(1120-1122)GAA>AAA	p.E374K	CLIP2_uc003uan.2_Missense_Mutation_p.E374K	NM_003388	NP_003379	Q9UDT6	CLIP2_HUMAN	CAP-GLY domain containing linker protein 2	374	Potential.					microtubule associated complex				skin(3)	3						GCTGCTGGCTGAACGAGACCT	0.612		NaN											0	0	0	0.001984	0	6	9									
CLIP2	7461	broad.mit.edu	37	7	73811473	73811473	+	Silent	SNP	G	G	C			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr7:73811473G>C	uc003uam.2	+	14	3117	c.2790G>C	c.(2788-2790)CTG>CTC	p.L930L	CLIP2_uc003uan.2_Silent_p.L895L	NM_003388	NP_003379	Q9UDT6	CLIP2_HUMAN	CAP-GLY domain containing linker protein 2	930	Potential.					microtubule associated complex				skin(3)	3						AGAGGGACCTGAGCCGTGAGG	0.627		NaN											0	0	0	0.010729	0	11	28									
ZC3HAV1L	92092	broad.mit.edu	37	7	138711457	138711457	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr7:138711457G>A	uc003vum.1	-	4	895	c.883C>T	c.(883-885)CCA>TCA	p.P295S		NM_080660	NP_542391	Q96H79	ZCCHL_HUMAN	zinc finger CCCH-type, antiviral 1-like	295											0						GGTTTACCTGGGCAGGGCTTC	0.502		NaN											0	0	0	0.014758	0	5	93									
CUL1	8454	broad.mit.edu	37	7	148487405	148487405	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr7:148487405G>A	uc010lpg.2	+	16	2204	c.1678G>A	c.(1678-1680)GAA>AAA	p.E560K	CUL1_uc003wey.2_Missense_Mutation_p.E560K|CUL1_uc003wez.2_Missense_Mutation_p.E450K|CUL1_uc003wfa.2_Missense_Mutation_p.E221K	NM_003592	NP_003583	Q13616	CUL1_HUMAN	cullin 1	560					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell cycle arrest|G1/S transition of mitotic cell cycle|induction of apoptosis by intracellular signals|interspecies interaction between organisms|negative regulation of cell proliferation|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein ubiquitination|S phase of mitotic cell cycle|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	cytosol|nucleoplasm|SCF ubiquitin ligase complex	ubiquitin protein ligase binding			lung(1)	1	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00291)			TATCTAGTTGGAACGTAGTTA	0.428		NaN											0	0	0	0.007413	0	14	35									
CSMD1	64478	broad.mit.edu	37	8	3000065	3000065	+	Missense_Mutation	SNP	T	T	C			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr8:3000065T>C	uc011kwk.1	-	41	6556	c.6166A>G	c.(6166-6168)AGC>GGC	p.S2056G	CSMD1_uc011kwj.1_Missense_Mutation_p.S1448G|CSMD1_uc010lrg.2_Missense_Mutation_p.S124G	NM_033225	NP_150094	Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1 precursor	2056	Extracellular (Potential).|CUB 12.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		TGCGTTGTGCTCAGCAGGGCC	0.478		NaN											0	0	0	0.001168	0	6	36									
SCARA3	51435	broad.mit.edu	37	8	27507313	27507313	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr8:27507313G>C	uc003xga.1	+	2	243	c.102G>C	c.(100-102)CAG>CAC	p.Q34H	SCARA3_uc003xgb.1_Missense_Mutation_p.Q34H	NM_016240	NP_057324	Q6AZY7	SCAR3_HUMAN	scavenger receptor class A, member 3 isoform 1	34	Cytoplasmic (Potential).				response to oxidative stress|UV protection	collagen|endoplasmic reticulum membrane|Golgi membrane|integral to membrane	scavenger receptor activity			skin(2)|ovary(1)|breast(1)	4		Ovarian(32;2.61e-05)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0219)|Colorectal(74;0.148)		CATGCACCCAGAAGGGTAAGG	0.592		NaN											0	0	0	0.00308	0	8	17									
PURG	29942	broad.mit.edu	37	8	30890034	30890034	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr8:30890034C>T	uc003xin.2	-	1	284	c.265G>A	c.(265-267)GAA>AAA	p.E89K	WRN_uc003xio.3_5'Flank|PURG_uc003xim.1_Missense_Mutation_p.E89K	NM_013357	NP_037489	Q9UJV8	PURG_HUMAN	purine-rich element binding protein G isoform A	89	By similarity.					nucleus	DNA binding				0				KIRC - Kidney renal clear cell carcinoma(542;0.0895)|Kidney(114;0.108)		ATCCAGACTTCGGCTATCTTT	0.542		NaN											0	0	0	0.003163	0	16	27									
GOT1L1	137362	broad.mit.edu	37	8	37791899	37791899	+	Missense_Mutation	SNP	T	T	A			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr8:37791899T>A	uc011lbj.1	-	9	1278	c.1178A>T	c.(1177-1179)GAG>GTG	p.E393V		NM_152413	NP_689626	Q8NHS2	AATC2_HUMAN	glutamic-oxaloacetic transaminase 1-like 1	393					biosynthetic process|cellular amino acid metabolic process	cytoplasm	pyridoxal phosphate binding|transaminase activity			ovary(1)	1	Colorectal(12;0.00627)	Lung NSC(58;0.118)|all_lung(54;0.195)	LUSC - Lung squamous cell carcinoma(8;1.37e-11)			ATTGATGCCCTCAGTGATGTA	0.408		NaN											0	0	0	0.009718	0	42	86									
POTEA	340441	broad.mit.edu	37	8	43197470	43197470	+	Silent	SNP	C	C	T			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr8:43197470C>T	uc003xpz.1	+	11	1402	c.1359C>T	c.(1357-1359)AAC>AAT	p.N453N	POTEA_uc003xqa.1_Silent_p.N407N	NM_001005365	NP_001005365	Q6S8J7	POTEA_HUMAN	POTE ankyrin domain family, member A isoform 2	453										ovary(1)	1						TGGATTTTAACGGTAGGACCA	0.373		NaN											0	0	0	0.004656	0	21	35									
NPBWR1	2831	broad.mit.edu	37	8	53853373	53853373	+	Silent	SNP	C	C	T			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr8:53853373C>T	uc011ldu.1	+	1	906	c.906C>T	c.(904-906)CTC>CTT	p.L302L		NM_005285	NP_005276	P48145	NPBW1_HUMAN	G protein-coupled receptor 7	302	Cytoplasmic (Potential).				synaptic transmission	plasma membrane	opioid receptor activity|protein binding			ovary(2)|breast(1)	3		Lung NSC(129;0.0222)|all_epithelial(80;0.0301)|all_lung(136;0.0431)				ACAGCTGCCTCAACCCCTTCC	0.652		NaN											0	0	0	0.016723	0	11	24									
ANKRD46	157567	broad.mit.edu	37	8	101540176	101540176	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr8:101540176C>G	uc003yjm.2	-	4	571	c.367G>C	c.(367-369)GAT>CAT	p.D123H	ANKRD46_uc003yjn.1_Missense_Mutation_p.D123H|ANKRD46_uc003yjo.1_Missense_Mutation_p.D123H|ANKRD46_uc003yjp.1_Missense_Mutation_p.D123H	NM_198401	NP_940683	Q86W74	ANR46_HUMAN	ankyrin repeat domain 46	123	ANK 4.					integral to membrane					0	all_cancers(14;5.07e-05)|all_epithelial(15;2.84e-07)|Lung NSC(17;0.000353)|all_lung(17;0.000998)		Epithelial(11;2.61e-11)|all cancers(13;5.03e-09)|OV - Ovarian serous cystadenocarcinoma(57;4.49e-06)|STAD - Stomach adenocarcinoma(118;0.0957)			CGGATGACATCTTTATTTACT	0.383		NaN											0	0	0	0.01892	0	22	67									
CSMD3	114788	broad.mit.edu	37	8	113358422	113358422	+	Missense_Mutation	SNP	A	A	G			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr8:113358422A>G	uc003ynu.2	-	41	6505	c.6346T>C	c.(6346-6348)TCA>CCA	p.S2116P	CSMD3_uc003yns.2_Missense_Mutation_p.S1318P|CSMD3_uc003ynt.2_Missense_Mutation_p.S2076P|CSMD3_uc011lhx.1_Missense_Mutation_p.S2012P	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	2116	Extracellular (Potential).|CUB 12.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						CTGAAGTCTGACATAGCACCA	0.373		NaN								HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			0	0	0	0.004007	0	15	43									
C9orf23	138716	broad.mit.edu	37	9	34611268	34611268	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr9:34611268G>A	uc003zuu.2	-	2	307	c.26C>T	c.(25-27)TCT>TTT	p.S9F	C9orf23_uc003zuv.2_Missense_Mutation_p.S9F	NM_148179	NP_680545	Q8N5L8	CI023_HUMAN	hypothetical protein LOC138716	9							nucleic acid binding				0	all_epithelial(49;0.0863)		STAD - Stomach adenocarcinoma(86;0.178)	GBM - Glioblastoma multiforme(74;0.0385)		GAGCTCTACAGAGCCAGCTTT	0.577		NaN											0	0	0	0.001168	0	5	14									
OR1N2	138882	broad.mit.edu	37	9	125316096	125316096	+	Silent	SNP	C	C	A			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr9:125316096C>A	uc011lyx.1	+	1	648	c.648C>A	c.(646-648)ATC>ATA	p.I216I		NM_001004457	NP_001004457	Q8NGR9	OR1N2_HUMAN	olfactory receptor, family 1, subfamily N,	216	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(2)	4						AGCTGATGATCATCACCATGG	0.502		NaN											1	0	4.67007e-22	0.00874	5.11576e-22	32	63									
RABEPK	10244	broad.mit.edu	37	9	127996161	127996161	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr9:127996161G>A	uc004bpi.2	+	9	1194	c.1021G>A	c.(1021-1023)GAG>AAG	p.E341K	RABEPK_uc004bpj.2_Missense_Mutation_p.E290K|RABEPK_uc004bpk.2_Missense_Mutation_p.E341K|RABEPK_uc004bpl.1_3'UTR|RABEPK_uc004bpm.2_Missense_Mutation_p.E341K	NM_005833	NP_005824	Q7Z6M1	RABEK_HUMAN	Rab9 effector protein with kelch motifs	341					receptor-mediated endocytosis|vesicle docking involved in exocytosis	endosome membrane|plasma membrane				ovary(1)	1						TGACTCACATGAGGAAAGCCA	0.438		NaN											0	0	0	0.009535	0	32	65									
RABEPK	10244	broad.mit.edu	37	9	127996208	127996208	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr9:127996208G>A	uc004bpi.2	+	9	1241	c.1068G>A	c.(1066-1068)ATG>ATA	p.M356I	RABEPK_uc004bpj.2_Missense_Mutation_p.M305I|RABEPK_uc004bpk.2_Missense_Mutation_p.M356I|RABEPK_uc004bpl.1_3'UTR|RABEPK_uc004bpm.2_Missense_Mutation_p.M356I	NM_005833	NP_005824	Q7Z6M1	RABEK_HUMAN	Rab9 effector protein with kelch motifs	356					receptor-mediated endocytosis|vesicle docking involved in exocytosis	endosome membrane|plasma membrane				ovary(1)	1						TTGGTGGGATGAATACAGAAG	0.408		NaN											0	0	0	0.007835	0	37	85									
RABEPK	10244	broad.mit.edu	37	9	127996215	127996215	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr9:127996215G>A	uc004bpi.2	+	9	1248	c.1075G>A	c.(1075-1077)GAA>AAA	p.E359K	RABEPK_uc004bpj.2_Missense_Mutation_p.E308K|RABEPK_uc004bpk.2_Missense_Mutation_p.E359K|RABEPK_uc004bpl.1_3'UTR|RABEPK_uc004bpm.2_Missense_Mutation_p.E359K	NM_005833	NP_005824	Q7Z6M1	RABEK_HUMAN	Rab9 effector protein with kelch motifs	359					receptor-mediated endocytosis|vesicle docking involved in exocytosis	endosome membrane|plasma membrane				ovary(1)	1						GATGAATACAGAAGGGGAAAT	0.398		NaN											0	0	0	0.007835	0	36	86									
CRAT	1384	broad.mit.edu	37	9	131870096	131870096	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr9:131870096G>C	uc004bxh.2	-	2	570	c.288C>G	c.(286-288)AAC>AAG	p.N96K	CRAT_uc004bxg.2_Missense_Mutation_p.N75K|CRAT_uc004bxk.3_Missense_Mutation_p.N75K|CRAT_uc004bxj.2_Missense_Mutation_p.N97K	NM_000755	NP_000746	P43155	CACP_HUMAN	carnitine acetyltransferase precursor	96					energy derivation by oxidation of organic compounds|fatty acid beta-oxidation using acyl-CoA oxidase|transport	endoplasmic reticulum|mitochondrial inner membrane|peroxisomal matrix	carnitine O-acetyltransferase activity			central_nervous_system(1)	1				UCEC - Uterine corpus endometrioid carcinoma (4;0.0178)	L-Carnitine(DB00583)	CACTCACCCAGTTCTCCGTCT	0.637		NaN											0	0	0	0.008291	0	9	13									
ABL1	25	broad.mit.edu	37	9	133589745	133589745	+	Silent	SNP	A	A	G			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr9:133589745A>G	uc004bzv.2	+	1	478	c.39A>G	c.(37-39)AGA>AGG	p.R13R		NM_007313	NP_009297	P00519	ABL1_HUMAN	c-abl oncogene 1, receptor tyrosine kinase	Error:Variant_position_missing_in_P00519_after_alignment					actin cytoskeleton organization|axon guidance|blood coagulation|cell adhesion|DNA damage induced protein phosphorylation|DNA damage response, signal transduction resulting in induction of apoptosis|mismatch repair|muscle cell differentiation|negative regulation of protein serine/threonine kinase activity|peptidyl-tyrosine phosphorylation|positive regulation of muscle cell differentiation|positive regulation of oxidoreductase activity|regulation of transcription involved in S phase of mitotic cell cycle	cytoskeleton|cytosol|nuclear membrane|nucleolus|perinuclear region of cytoplasm	ATP binding|DNA binding|magnesium ion binding|manganese ion binding|mitogen-activated protein kinase binding|non-membrane spanning protein tyrosine kinase activity|proline-rich region binding|protein C-terminus binding|SH3 domain binding			haematopoietic_and_lymphoid_tissue(807)|lung(5)|stomach(2)|central_nervous_system(1)|breast(1)|skin(1)	817		all_hematologic(13;0.0361)|Acute lymphoblastic leukemia(5;0.0543)|Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;5.4e-05)	Adenosine triphosphate(DB00171)|Dasatinib(DB01254)|Imatinib(DB00619)	GGGACCAAAGAAGGCCAAGCT	0.498		NaN	T|Mis	BCR|ETV6|NUP214	CML|ALL|T-ALL								0	0	0	0.010504	0	21	21									
PTCHD1	139411	broad.mit.edu	37	X	23398359	23398359	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chrX:23398359G>A	uc004dal.3	+	2	1011	c.1003G>A	c.(1003-1005)GTC>ATC	p.V335I	PTCHD1_uc010nfu.1_Missense_Mutation_p.V335I	NM_173495	NP_775766	Q96NR3	PTHD1_HUMAN	patched domain containing 1	335	Helical; (Potential).|SSD.				cognition|smoothened signaling pathway	integral to membrane|plasma membrane	hedgehog receptor activity			ovary(4)|kidney(1)|skin(1)	6						AGTCCCTTTCGTCATGCTAGG	0.483		NaN											0	0	0	0.013537	0	10	83									
RBM10	8241	broad.mit.edu	37	X	47044531	47044531	+	Silent	SNP	C	C	A			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chrX:47044531C>A	uc004dhf.2	+	18	2407	c.2028C>A	c.(2026-2028)ATC>ATA	p.I676I	RBM10_uc004dhg.2_Silent_p.I598I|RBM10_uc004dhh.2_Silent_p.I675I|RBM10_uc010nhq.2_Silent_p.I599I|RBM10_uc004dhi.2_Silent_p.I741I	NM_005676	NP_005667	P98175	RBM10_HUMAN	RNA binding motif protein 10 isoform 1	676					mRNA processing|RNA splicing	chromatin remodeling complex	nucleotide binding|RNA binding|zinc ion binding			ovary(1)|large_intestine(1)|prostate(1)|breast(1)|pancreas(1)	5						TCCAGCCTATCAGCTCCCTGC	0.567		NaN											1	0	3.27435e-08	0.020292	3.49971e-08	13	26									
CFP	5199	broad.mit.edu	37	X	47485822	47485822	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chrX:47485822C>T	uc004dig.3	-	7	1163	c.1037G>A	c.(1036-1038)CGC>CAC	p.R346H	CFP_uc004dih.2_Missense_Mutation_p.R346H|CFP_uc004dii.1_Missense_Mutation_p.R282H|CFP_uc010nhu.2_Missense_Mutation_p.R346H	NM_001145252	NP_001138724	P27918	PROP_HUMAN	complement factor properdin precursor	346	TSP type-1 5.				complement activation, alternative pathway|defense response to bacterium	extracellular space				breast(2)|lung(1)	3						GGTCCTCCCGCGTGACTGCTG	0.622		NaN											0	0	0	0.020292	0	12	23									
SMC1A	8243	broad.mit.edu	37	X	53436094	53436094	+	Nonsense_Mutation	SNP	C	C	A			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chrX:53436094C>A	uc004dsg.2	-	9	1513	c.1444G>T	c.(1444-1446)GAG>TAG	p.E482*	SMC1A_uc011moe.1_Nonsense_Mutation_p.E460*|SMC1A_uc011mof.1_Nonsense_Mutation_p.E248*	NM_006306	NP_006297	Q14683	SMC1A_HUMAN	structural maintenance of chromosomes 1A	482	Potential.				cell cycle checkpoint|cell division|DNA repair|meiosis|mitotic metaphase/anaphase transition|mitotic prometaphase|mitotic sister chromatid cohesion|mitotic spindle organization|negative regulation of DNA endoreduplication|nuclear mRNA splicing, via spliceosome|response to radiation|signal transduction in response to DNA damage	cohesin core heterodimer|condensed chromosome kinetochore|condensed nuclear chromosome|cytoplasm|meiotic cohesin complex|nucleoplasm	ATP binding|chromatin binding|microtubule motor activity|protein heterodimerization activity			ovary(5)|central_nervous_system(1)	6						CCTAGCTGCTCCATCACCTGG	0.562		NaN											1	0	2.27111e-07	0.013537	2.40792e-07	13	37									
PHF8	23133	broad.mit.edu	37	X	54022189	54022189	+	Silent	SNP	G	G	A			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chrX:54022189G>A	uc004dsu.2	-	12	1441	c.1368C>T	c.(1366-1368)ATC>ATT	p.I456I	PHF8_uc004dst.2_Silent_p.I420I|PHF8_uc004dsv.2_Silent_p.I286I|PHF8_uc004dsw.2_Silent_p.I420I|PHF8_uc004dsx.2_Silent_p.I184I|PHF8_uc004dsy.2_Silent_p.I420I	NM_015107	NP_055922	Q9UPP1	PHF8_HUMAN	PHD finger protein 8	456					brain development|G1/S transition of mitotic cell cycle|negative regulation of chromatin silencing at rDNA|positive regulation of transcription from RNA polymerase I promoter|transcription, DNA-dependent	nucleolus	chromatin binding|histone demethylase activity (H3-K27 specific)|histone demethylase activity (H3-K36 specific)|histone demethylase activity (H3-K9 specific)|histone demethylase activity (H4-K20 specific)|iron ion binding|methylated histone residue binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|zinc ion binding			ovary(3)	3						CTGTCTCCGGGATCTCATCCT	0.393		NaN											0	0	0	0.001984	0	7	20									
ZMYM3	9203	broad.mit.edu	37	X	70470474	70470474	+	Nonsense_Mutation	SNP	G	G	C			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chrX:70470474G>C	uc004dzh.1	-	5	968	c.881C>G	c.(880-882)TCA>TGA	p.S294*	BCYRN1_uc011mpt.1_Intron|ZMYM3_uc004dzi.1_Nonsense_Mutation_p.S294*|ZMYM3_uc004dzj.1_Nonsense_Mutation_p.S294*|ZMYM3_uc011mpu.1_Nonsense_Mutation_p.S25*|ZMYM3_uc004dzk.3_Nonsense_Mutation_p.S294*|ZMYM3_uc004dzl.3_Nonsense_Mutation_p.S294*|ZMYM3_uc004dzm.3_Nonsense_Mutation_p.S294*	NM_201599	NP_963893	Q14202	ZMYM3_HUMAN	zinc finger protein 261	294					multicellular organismal development	nucleus	DNA binding|zinc ion binding			ovary(1)	1	Renal(35;0.156)					TGACACACTTGAGCGTAGGGA	0.587		NaN											0	0	0	0.014758	0	5	15									
TXNIP	10628	broad.mit.edu	37	1	145438899	145438900	+	Frame_Shift_Ins	INS	-	-	T			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08			-	T	-	-		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr1:145438899_145438900insT	uc001enn.3	+	1	438_439	c.97_98insT	c.(97-99)GTGfs	p.V33fs	NBPF10_uc001emp.3_Intron|TXNIP_uc001enm.1_Intron|TXNIP_uc010oys.1_5'Flank	NM_006472	NP_006463	Q9H3M7	TXNIP_HUMAN	thioredoxin interacting protein	33					cell cycle|keratinocyte differentiation|transcription, DNA-dependent		ubiquitin protein ligase binding			ovary(2)	2	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					CCGGGTGATAGTGGAGGTGTGT	0.515		NaN											NaN	NaN	NaN	NaN	NaN	7	31	---	---							
RAB3IL1	5866	broad.mit.edu	37	11	61675683	61675683	+	Frame_Shift_Del	DEL	G	G	-			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr11:61675683delG	uc001nso.2	-	2	265	c.107delC	c.(106-108)CCAfs	p.P36fs	RAB3IL1_uc001nsp.2_Frame_Shift_Del_p.P83fs	NM_013401	NP_037533	Q8TBN0	R3GEF_HUMAN	RAB3A interacting protein (rabin3)-like 1	36							protein binding			skin(2)|central_nervous_system(1)	3						CAGGGCTCCTGGGGACTCCCT	0.721		NaN											NaN	NaN	NaN	NaN	NaN	2	4	---	---							
PAN2	9924	broad.mit.edu	37	12	56720730	56720730	+	Frame_Shift_Del	DEL	G	G	-			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr12:56720730delG	uc001skx.2	-	7	1306	c.933delC	c.(931-933)TTCfs	p.F311fs	PAN2_uc001skw.2_5'Flank|PAN2_uc001skz.2_Frame_Shift_Del_p.F311fs|PAN2_uc001sky.2_Frame_Shift_Del_p.F311fs	NM_001127460	NP_001120932	Q504Q3	PAN2_HUMAN	PAN2 polyA specific ribonuclease subunit homolog	311					nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA poly(A) tail shortening|ubiquitin-dependent protein catabolic process	cytosol|nucleus	nucleic acid binding|poly(A)-specific ribonuclease activity|ubiquitin thiolesterase activity			ovary(2)|skin(2)|large_intestine(1)|breast(1)	6						TGGGTTCACAGAATTGGCACT	0.512		NaN											NaN	NaN	NaN	NaN	NaN	17	44	---	---							
GTF3A	2971	broad.mit.edu	37	13	28006890	28006890	+	Frame_Shift_Del	DEL	A	A	-			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr13:28006890delA	uc001ure.2	+	5	705	c.511delA	c.(511-513)AAAfs	p.K171fs	GTF3A_uc001urf.2_Intron|GTF3A_uc001urg.2_RNA	NM_002097	NP_002088	Q92664	TF3A_HUMAN	transcription factor IIIA	171	C2H2-type 5.				regulation of transcription, DNA-dependent|rRNA transcription|transcription from RNA polymerase III promoter	nucleoplasm	DNA binding|protein binding|RNA binding|zinc ion binding				0		Lung SC(185;0.0156)	Colorectal(13;0.00042)|READ - Rectum adenocarcinoma(15;0.105)	all cancers(112;0.11)|OV - Ovarian serous cystadenocarcinoma(117;0.158)		AGGATGTGGGAAACACTTTGC	0.532		NaN											NaN	NaN	NaN	NaN	NaN	3	5	---	---							
B3GNT2	10678	broad.mit.edu	37	2	62449660	62449673	+	Frame_Shift_Del	DEL	TCACGTCGGTGGTT	TCACGTCGGTGGTT	-	rs72893877	byFrequency	TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr2:62449660_62449673delTCACGTCGGTGGTT	uc002sbs.2	+	2	543_556	c.305_318delTCACGTCGGTGGTT	c.(304-318)GTCACGTCGGTGGTTfs	p.V102fs		NM_006577	NP_006568	Q9NY97	B3GN2_HUMAN	UDP-GlcNAc:betaGal	102_106	Lumenal (Potential).					Golgi membrane|integral to membrane	UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity			ovary(1)	1	Lung NSC(7;0.031)|all_lung(7;0.0634)		LUSC - Lung squamous cell carcinoma(7;3.55e-06)|Epithelial(17;0.0963)			GACCTGAGGGTCACGTCGGTGGTTACGGGTTTTA	0.5		NaN											NaN	NaN	NaN	NaN	NaN	21	332	---	---							
CENPC1	1060	broad.mit.edu	37	4	68358626	68358627	+	Frame_Shift_Ins	INS	-	-	T			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr4:68358626_68358627insT	uc003hdd.1	-	15	2562_2563	c.2379_2380insA	c.(2377-2382)AAATCTfs	p.K793fs	CENPC1_uc010ihj.1_RNA|CENPC1_uc010ihk.1_RNA|CENPC1_uc010ihl.2_5'UTR	NM_001812	NP_001803	Q03188	CENPC_HUMAN	centromere protein C 1	793_794	Nuclear localization signal (Potential).				mitotic prometaphase	condensed chromosome kinetochore|condensed nuclear chromosome, centromeric region|cytosol	DNA binding			urinary_tract(1)|lung(1)	2						TTCTTATTAGATTTTTTGTTGA	0.297		NaN											NaN	NaN	NaN	NaN	NaN	2	4	---	---							
C5orf45	51149	broad.mit.edu	37	5	179264671	179264700	+	In_Frame_Del	DEL	TGAAGAGACCTTGGCTGCTCACTGTCCACA	TGAAGAGACCTTGGCTGCTCACTGTCCACA	-	rs61742526	byFrequency	TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr5:179264671_179264700delTGAAGAGACCTTGGCTGCTCACTGTCCACA	uc003mla.2	-	7	767_796	c.723_752delTGTGGACAGTGAGCAGCCAAGGTCTCTTCA	c.(721-753)CATGTGGACAGTGAGCAGCCAAGGTCTCTTCAG>CAG	p.HVDSEQPRSL241del	SQSTM1_uc011dgr.1_3'UTR|SQSTM1_uc011dgs.1_3'UTR|SQSTM1_uc003mkw.3_3'UTR|SQSTM1_uc003mkx.2_3'UTR|C5orf45_uc003mky.2_Intron|C5orf45_uc011dgt.1_Intron|C5orf45_uc011dgu.1_Intron|C5orf45_uc003mlc.2_In_Frame_Del_p.HVDSEQPRSL186del|C5orf45_uc003mlb.2_In_Frame_Del_p.HVDSEQPRSL107del	NM_016175	NP_057259	Q6NTE8	CE045_HUMAN	hypothetical protein LOC51149 isoform 1	241_250											0						GGGGTCCCTCTGAAGAGACCTTGGCTGCTCACTGTCCACATGTGAACTTT	0.587		NaN											NaN	NaN	NaN	NaN	NaN	7	28	---	---							
SPTAN1	6709	broad.mit.edu	37	9	131367428	131367429	+	Frame_Shift_Del	DEL	GA	GA	-			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr9:131367428_131367429delGA	uc004bvl.3	+	30	3948_3949	c.3835_3836delGA	c.(3835-3837)GAGfs	p.E1279fs	SPTAN1_uc011mbh.1_Frame_Shift_Del_p.E1291fs|SPTAN1_uc004bvm.3_Frame_Shift_Del_p.E1279fs|SPTAN1_uc004bvn.3_Frame_Shift_Del_p.E1259fs	NM_003127	NP_003118	Q13813	SPTA2_HUMAN	spectrin, alpha, non-erythrocytic 1	1279	Spectrin 14.				actin filament capping|axon guidance|cellular component disassembly involved in apoptosis	cytosol|intracellular membrane-bounded organelle|membrane fraction|microtubule cytoskeleton|spectrin	actin binding|calcium ion binding|calmodulin binding|structural constituent of cytoskeleton			breast(5)|ovary(4)|pancreas(1)	10						TGAGGGCTTCGAGAGGGACCTT	0.5		NaN											NaN	NaN	NaN	NaN	NaN	11	22	---	---