Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	isArtifactMode	oxoGCut	pox	pox_cutoff	qox	t_alt_count	t_ref_count	validation_alt_allele	validation_tumor_sample							
HTR1D	3352	broad.mit.edu	37	1	23519904	23519904	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr1:23519904G>A	uc001bgn.2	-	1	1319	c.809C>T	c.(808-810)TCC>TTC	p.S270F		NM_000864	NP_000855	P28221	5HT1D_HUMAN	5-hydroxytryptamine (serotonin) receptor 1D	270	Cytoplasmic (By similarity).				G-protein signaling, coupled to cyclic nucleotide second messenger|intestine smooth muscle contraction|synaptic transmission	integral to plasma membrane	serotonin receptor activity				0		Colorectal(325;0.000147)|Renal(390;0.000734)|Lung NSC(340;0.000779)|all_lung(284;0.00135)|Breast(348;0.0385)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0561)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;4.69e-27)|Colorectal(126;4.86e-08)|COAD - Colon adenocarcinoma(152;2.86e-06)|GBM - Glioblastoma multiforme(114;0.00012)|BRCA - Breast invasive adenocarcinoma(304;0.000949)|KIRC - Kidney renal clear cell carcinoma(1967;0.00122)|STAD - Stomach adenocarcinoma(196;0.0123)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.083)|LUSC - Lung squamous cell carcinoma(448;0.185)	Almotriptan(DB00918)|Dihydroergotamine(DB00320)|Eletriptan(DB00216)|Ergotamine(DB00696)|Frovatriptan(DB00998)|Naratriptan(DB00952)|Rizatriptan(DB00953)|Sumatriptan(DB00669)|Tegaserod(DB01079)|Ziprasidone(DB00246)|Zolmitriptan(DB00315)	AAAGAGAGGGGAGCCAGCCGA	0.572		NaN											0	0	0	0.021022	0	34	46									
CYP4A22	284541	broad.mit.edu	37	1	47603170	47603170	+	Missense_Mutation	SNP	G	G	T			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr1:47603170G>T	uc001cqv.1	+	1	64	c.13G>T	c.(13-15)GTC>TTC	p.V5F	CYP4A22_uc009vyo.2_Missense_Mutation_p.V5F|CYP4A22_uc009vyp.2_Missense_Mutation_p.V5F	NM_001010969	NP_001010969	Q5TCH4	CP4AM_HUMAN	cytochrome P450, family 4, subfamily A,	5						endoplasmic reticulum membrane|microsome	alkane 1-monooxygenase activity|electron carrier activity|heme binding			skin(2)|ovary(1)|breast(1)	4						GAGTGTCTCTGTCCTGAGCCC	0.587		NaN											1	0	3.10996e-30	0.01441	4.51249e-30	43	75									
ELAVL4	1996	broad.mit.edu	37	1	50610812	50610812	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr1:50610812C>T	uc001csb.2	+	2	461	c.193C>T	c.(193-195)CTC>TTC	p.L65F	ELAVL4_uc001cry.3_Missense_Mutation_p.L68F|ELAVL4_uc001crz.3_Missense_Mutation_p.L65F|ELAVL4_uc001csa.3_Missense_Mutation_p.L82F|ELAVL4_uc001csc.3_Missense_Mutation_p.L65F|ELAVL4_uc009vyu.2_Missense_Mutation_p.L70F|ELAVL4_uc010omz.1_Missense_Mutation_p.L70F	NM_021952	NP_068771	P26378	ELAV4_HUMAN	ELAV-like 4 isoform 1	65	RRM 1.				mRNA processing		AU-rich element binding|mRNA 3'-UTR binding|nucleotide binding			ovary(1)|pancreas(1)	2						ATTCAGGAGTCTCTTCGGGAG	0.433		NaN											0	0	0	0.003163	0	13	78									
COL11A1	1301	broad.mit.edu	37	1	103461428	103461428	+	Missense_Mutation	SNP	C	C	A			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr1:103461428C>A	uc001dul.2	-	28	2650	c.2332G>T	c.(2332-2334)GGT>TGT	p.G778C	COL11A1_uc001duk.2_Translation_Start_Site|COL11A1_uc001dum.2_Missense_Mutation_p.G790C|COL11A1_uc001dun.2_Missense_Mutation_p.G739C|COL11A1_uc009weh.2_Missense_Mutation_p.G662C	NM_001854	NP_001845	P12107	COBA1_HUMAN	alpha 1 type XI collagen isoform A	778	Triple-helical region.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			ovary(6)|breast(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	12		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		ACCTTTTCACCTTTAGATCCC	0.269		NaN											1	0	8.52622e-23	0.01441	1.15769e-22	52	40									
KCNC4	3749	broad.mit.edu	37	1	110754241	110754241	+	Silent	SNP	C	C	T			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr1:110754241C>T	uc001dzh.2	+	1	177	c.120C>T	c.(118-120)ATC>ATT	p.I40I	KCNC4_uc001dzf.2_Silent_p.I40I|KCNC4_uc009wfr.2_Silent_p.I40I|KCNC4_uc001dzg.2_Silent_p.I40I|KCNC4_uc001dzi.2_RNA	NM_004978	NP_004969	Q03721	KCNC4_HUMAN	Shaw-related voltage-gated potassium channel	40	Cytoplasmic (Potential).				synaptic transmission	voltage-gated potassium channel complex	voltage-gated potassium channel activity			large_intestine(1)|ovary(1)|central_nervous_system(1)	3		all_cancers(81;9.88e-06)|all_epithelial(167;3.23e-06)|all_lung(203;0.000116)|Lung NSC(277;0.000233)		Lung(183;0.0238)|all cancers(265;0.0693)|Epithelial(280;0.0748)|Colorectal(144;0.112)|LUSC - Lung squamous cell carcinoma(189;0.135)		AGATCATCATCAACGTGGGCG	0.677		NaN											0	0	0	0.004656	0	20	35									
SPAG17	200162	broad.mit.edu	37	1	118537064	118537064	+	Silent	SNP	G	G	T			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr1:118537064G>T	uc001ehk.2	-	35	5211	c.5143C>A	c.(5143-5145)CGG>AGG	p.R1715R		NM_206996	NP_996879	Q6Q759	SPG17_HUMAN	sperm associated antigen 17	1715						cilium|flagellar axoneme|microtubule				upper_aerodigestive_tract(2)|ovary(2)|large_intestine(1)|skin(1)	6	Esophageal squamous(2;0.0106)	all_cancers(81;0.0204)|all_lung(203;9.46e-05)|Lung NSC(69;0.000675)|all_epithelial(167;0.01)		Lung(183;0.0858)		GACCTTGACCGGAGATTAGGA	0.428		NaN											1	0	6.70999e-13	0.019004	7.88157e-13	27	49									
OR6Y1	391112	broad.mit.edu	37	1	158517011	158517011	+	Nonsense_Mutation	SNP	G	G	T			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr1:158517011G>T	uc010pil.1	-	1	885	c.885C>A	c.(883-885)TAC>TAA	p.Y295*		NM_001005189	NP_001005189	Q8NGX8	OR6Y1_HUMAN	olfactory receptor, family 6, subfamily Y,	295	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	all_hematologic(112;0.0378)					TCCTCAGACAGTAAATGATGG	0.458		NaN											1	0	1.81118e-26	0.01441	2.57745e-26	40	67									
KIFAP3	22920	broad.mit.edu	37	1	169951164	169951164	+	Missense_Mutation	SNP	C	C	A			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr1:169951164C>A	uc001ggv.2	-	15	2018	c.1747G>T	c.(1747-1749)GCA>TCA	p.A583S	KIFAP3_uc010plx.1_Missense_Mutation_p.A285S	NM_014970	NP_055785	Q92845	KIFA3_HUMAN	kinesin-associated protein 3	583	ARM 4.				blood coagulation|plus-end-directed vesicle transport along microtubule|protein complex assembly|signal transduction	centrosome|condensed nuclear chromosome|cytosol|endoplasmic reticulum|kinesin II complex|spindle microtubule	kinesin binding			skin(1)	1	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					GCTAGCAATGCAGCACAAGAG	0.348		NaN											1	0	2.4375e-19	0.007291	3.13695e-19	23	31									
LGR6	59352	broad.mit.edu	37	1	202205106	202205106	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr1:202205106C>G	uc001gxu.2	+	4	413	c.413C>G	c.(412-414)CCG>CGG	p.P138R	LGR6_uc001gxv.2_Missense_Mutation_p.P86R|LGR6_uc009xab.2_RNA|LGR6_uc001gxw.2_Missense_Mutation_p.P95R|LGR6_uc009xac.1_5'Flank	NM_001017403	NP_001017403	Q9HBX8	LGR6_HUMAN	leucine-rich repeat-containing G protein-coupled	138	Extracellular (Potential).					integral to membrane|plasma membrane	protein-hormone receptor activity			large_intestine(4)|ovary(3)|skin(2)|pancreas(1)	10						TGGGAGCTGCCGAGCCTGCAG	0.607		NaN											0	0	0	0.004672	0	3	56									
CHRM3	1131	broad.mit.edu	37	1	240071577	240071577	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr1:240071577G>A	uc001hyp.2	+	5	1605	c.826G>A	c.(826-828)GAG>AAG	p.E276K		NM_000740	NP_000731	P20309	ACM3_HUMAN	cholinergic receptor, muscarinic 3	276	Basolateral sorting signal.|Cytoplasmic (By similarity).			E->D: Loss of basolateral sorting. No effect on basolateral sorting; when associated with L-280 and L-281.|E->A: Loss of basolateral sorting.	cell proliferation|energy reserve metabolic process|nervous system development|protein modification process|regulation of insulin secretion	basolateral plasma membrane|cell junction|integral to plasma membrane|postsynaptic membrane	muscarinic acetylcholine receptor activity|phosphatidylinositol phospholipase C activity			ovary(4)|skin(1)	5	Ovarian(103;0.127)	all_cancers(173;0.00567)|all_neural(198;0.203)	OV - Ovarian serous cystadenocarcinoma(106;0.00989)		Anisotropine Methylbromide(DB00517)|Atropine(DB00572)|Benzquinamide(DB00767)|Cevimeline(DB00185)|Cryptenamine(DB00785)|Cyclizine(DB01176)|Darifenacin(DB00496)|Diphemanil Methylsulfate(DB00729)|Diphenidol(DB01231)|Homatropine Methylbromide(DB00725)|Methotrimeprazine(DB01403)|Metixene(DB00340)|Olanzapine(DB00334)|Oxybutynin(DB01062)|Oxyphencyclimine(DB00383)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Solifenacin(DB01591)|Thiethylperazine(DB00372)|Tiotropium(DB01409)|Tolterodine(DB01036)|Tridihexethyl(DB00505)	GACAGAGGCAGAGACAGAAAA	0.488		NaN											0	0	0	0.008871	0	17	26									
ANKRD30A	91074	broad.mit.edu	37	10	37430754	37430754	+	Missense_Mutation	SNP	T	T	C			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr10:37430754T>C	uc001iza.1	+	7	860	c.761T>C	c.(760-762)GTG>GCG	p.V254A		NM_052997	NP_443723	Q9BXX3	AN30A_HUMAN	ankyrin repeat domain 30A	310						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(7)|breast(1)|skin(1)	9						GCACCCTTGGTGGAAAGAACA	0.502		NaN											0	0	0	0.004672	0	3	50									
ANKRD30A	91074	broad.mit.edu	37	10	37430773	37430773	+	Silent	SNP	G	G	A			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr10:37430773G>A	uc001iza.1	+	7	879	c.780G>A	c.(778-780)ACG>ACA	p.T260T		NM_052997	NP_443723	Q9BXX3	AN30A_HUMAN	ankyrin repeat domain 30A	316						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(7)|breast(1)|skin(1)	9						CACCTGACACGGCTGAAAGCT	0.493		NaN											0	0	0	0.009096	0	4	50									
GPRIN2	9721	broad.mit.edu	37	10	46999113	46999113	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr10:46999113C>T	uc001jec.2	+	3	368	c.233C>T	c.(232-234)TCT>TTT	p.S78F	GPRIN2_uc010qfq.1_5'Flank	NM_014696	NP_055511	O60269	GRIN2_HUMAN	G protein-regulated inducer of neurite outgrowth	78											0						GCACGGGCCTCTGGCCCCAAG	0.701		NaN											0	0	0	0.008291	0	7	48									
MYST4	23522	broad.mit.edu	37	10	76603021	76603021	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr10:76603021C>G	uc001jwn.1	+	3	899	c.406C>G	c.(406-408)CAA>GAA	p.Q136E	MYST4_uc001jwm.1_Missense_Mutation_p.Q136E|MYST4_uc001jwo.1_Missense_Mutation_p.Q136E|MYST4_uc001jwp.1_Missense_Mutation_p.Q136E	NM_012330	NP_036462	Q8WYB5	MYST4_HUMAN	MYST histone acetyltransferase (monocytic	136	H15.				histone H3 acetylation|negative regulation of transcription, DNA-dependent|nucleosome assembly|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	MOZ/MORF histone acetyltransferase complex|nucleosome	DNA binding|histone acetyltransferase activity|transcription factor binding|zinc ion binding			central_nervous_system(5)|ovary(4)|lung(3)|breast(2)|skin(1)|prostate(1)	16	all_cancers(46;0.0347)|all_epithelial(25;0.00236)|Prostate(51;0.0112)|Ovarian(15;0.0964)					TCTCAGAAGTCAAAGTGATCT	0.498		NaN	T	CREBBP	AML								0	0	0	0.00632	0	29	22									
BTAF1	9044	broad.mit.edu	37	10	93751881	93751881	+	Missense_Mutation	SNP	A	A	G			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr10:93751881A>G	uc001khr.2	+	21	2958	c.2860A>G	c.(2860-2862)ACC>GCC	p.T954A	BTAF1_uc001kht.1_Missense_Mutation_p.T392A	NM_003972	NP_003963	O14981	BTAF1_HUMAN	BTAF1 RNA polymerase II, B-TFIID transcription	954					negative regulation of transcription, DNA-dependent	nucleus	ATP binding|DNA binding|helicase activity|sequence-specific DNA binding transcription factor activity			ovary(1)|central_nervous_system(1)|skin(1)	3		Colorectal(252;0.0846)				ATTAGGATCCACCTCAGAAAA	0.358		NaN											0	0	0	0.020292	0	14	27									
PNLIPRP3	119548	broad.mit.edu	37	10	118228730	118228730	+	Missense_Mutation	SNP	C	C	A			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr10:118228730C>A	uc001lcl.3	+	9	1062	c.961C>A	c.(961-963)CCA>ACA	p.P321T		NM_001011709	NP_001011709	Q17RR3	LIPR3_HUMAN	pancreatic lipase-related protein 3 precursor	321					lipid catabolic process	extracellular region	triglyceride lipase activity			ovary(1)	1				all cancers(201;0.0131)		AGAAGGTTGCCCAACAATGGG	0.358		NaN											1	0	1.22574e-08	0.014323	1.37431e-08	18	19									
NLRP6	171389	broad.mit.edu	37	11	281667	281667	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr11:281667G>A	uc010qvs.1	+	4	1933	c.1933G>A	c.(1933-1935)GCG>ACG	p.A645T	NLRP6_uc010qvt.1_Missense_Mutation_p.A645T	NM_138329	NP_612202	P59044	NALP6_HUMAN	NLR family, pyrin domain containing 6	645						cytoplasm	ATP binding			upper_aerodigestive_tract(1)|skin(1)	2		all_cancers(49;1.12e-06)|all_epithelial(84;0.000375)|Breast(177;0.00122)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;4.28e-28)|Epithelial(43;2.47e-27)|OV - Ovarian serous cystadenocarcinoma(40;4.66e-21)|BRCA - Breast invasive adenocarcinoma(625;3.57e-05)|Lung(200;0.0485)|LUSC - Lung squamous cell carcinoma(625;0.122)		CCCGGAGCTGGCGCTGCAGCG	0.647		NaN											0	0	0	0.01441	0	83	93									
NUP98	4928	broad.mit.edu	37	11	3744407	3744407	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr11:3744407G>C	uc001lyh.2	-	16	2417	c.2126C>G	c.(2125-2127)TCT>TGT	p.S709C	NUP98_uc001lyi.2_Missense_Mutation_p.S709C|NUP98_uc001lyj.1_Missense_Mutation_p.S709C|NUP98_uc001lyk.1_Missense_Mutation_p.S726C	NM_016320	NP_057404	P52948	NUP98_HUMAN	nucleoporin 98kD isoform 1	726					carbohydrate metabolic process|DNA replication|glucose transport|interspecies interaction between organisms|mitotic prometaphase|mRNA transport|nuclear pore organization|protein import into nucleus, docking|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear membrane|nucleoplasm|Nup107-160 complex	protein binding|structural constituent of nuclear pore|transporter activity			breast(4)|skin(3)|ovary(2)|central_nervous_system(1)|lung(1)|kidney(1)	12		Medulloblastoma(188;0.0025)|Breast(177;0.00328)|all_neural(188;0.0227)		BRCA - Breast invasive adenocarcinoma(625;0.0403)|LUSC - Lung squamous cell carcinoma(625;0.116)|Lung(200;0.199)		CATATGGTAAGAATTATTTTC	0.423		NaN	T	HOXA9|NSD1|WHSC1L1|DDX10|TOP1|HOXD13|PMX1|HOXA13|HOXD11|HOXA11|RAP1GDS1|HOXC11	AML								0	0	0	0.021022	0	32	50									
SBF2	81846	broad.mit.edu	37	11	9812207	9812207	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr11:9812207C>G	uc001mib.2	-	34	4732	c.4594G>C	c.(4594-4596)GAA>CAA	p.E1532Q	uc001mhz.1_Intron|SBF2_uc001mid.2_Missense_Mutation_p.E176Q|SBF2_uc001mic.2_5'Flank|uc001mie.3_Intron	NM_030962	NP_112224	Q86WG5	MTMRD_HUMAN	SET binding factor 2	1532	Myotubularin phosphatase.				myelination	cytoplasm|membrane	phosphatase activity|protein binding			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3				all cancers(16;2.88e-11)|Epithelial(150;3.61e-10)|BRCA - Breast invasive adenocarcinoma(625;0.00887)		GCATGCTTTTCTCCTTTATCA	0.308		NaN											0	0	0	0.010771	0	33	54									
OR4A5	81318	broad.mit.edu	37	11	51411647	51411647	+	Missense_Mutation	SNP	G	G	T			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr11:51411647G>T	uc001nhi.1	-	1	749	c.749C>A	c.(748-750)CCC>CAC	p.P250H		NM_001005272	NP_001005272	Q8NH83	OR4A5_HUMAN	olfactory receptor, family 4, subfamily A,	250	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|central_nervous_system(1)|skin(1)	3		all_lung(304;0.236)				GAAAATACAGGGTACAAAAAA	0.398		NaN											1	0	8.04996e-18	0.012319	1.02706e-17	19	31									
OR4C15	81309	broad.mit.edu	37	11	55322491	55322491	+	Silent	SNP	T	T	C			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr11:55322491T>C	uc010rig.1	+	1	709	c.709T>C	c.(709-711)TTA>CTA	p.L237L		NM_001001920	NP_001001920	Q8NGM1	OR4CF_HUMAN	olfactory receptor, family 4, subfamily C,	183	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						CTTGTACCCGTTACTGGAGCT	0.448		NaN								HNSCC(20;0.049)			0	0	0	0.020292	0	14	11									
OR10Q1	219960	broad.mit.edu	37	11	57996150	57996150	+	Silent	SNP	G	G	A			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr11:57996150G>A	uc010rkd.1	-	1	198	c.198C>T	c.(196-198)TTC>TTT	p.F66F		NM_001004471	NP_001004471	Q8NGQ4	O10Q1_HUMAN	olfactory receptor, family 10, subfamily Q,	66	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2		Breast(21;0.0589)				GGTTGGACAGGAAGAAATACA	0.532		NaN											0	0	0	0.007835	0	33	67									
MS4A1	931	broad.mit.edu	37	11	60229778	60229778	+	Translation_Start_Site	SNP	C	C	A			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr11:60229778C>A	uc001npp.2	+	3	347	c.-69C>A	c.(-71--67)GACTG>GAATG		MS4A1_uc009ymy.1_Intron|MS4A1_uc001npq.2_Intron|MS4A1_uc009yna.2_Translation_Start_Site|MS4A1_uc009ymz.2_Intron|MS4A1_uc010rlc.1_Intron	NM_152866	NP_690605	P11836	CD20_HUMAN	membrane-spanning 4-domains, subfamily A, member						B cell activation|immune response	integral to plasma membrane				ovary(3)|lung(2)	5					Ibritumomab(DB00078)|Rituximab(DB00073)|Tositumomab(DB00081)	CAAGGTAAGACTGCCAAAAAT	0.408		NaN											1	0	0.004672	0.004672	0.00483536	3	11									
A2M	2	broad.mit.edu	37	12	9262584	9262584	+	Missense_Mutation	SNP	C	C	A			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr12:9262584C>A	uc001qvk.1	-	6	665	c.552G>T	c.(550-552)GAG>GAT	p.E184D	A2M_uc009zgk.1_Missense_Mutation_p.E34D	NM_000014	NP_000005	P01023	A2MG_HUMAN	alpha-2-macroglobulin precursor	184					blood coagulation, intrinsic pathway|negative regulation of complement activation, lectin pathway|platelet activation|platelet degranulation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|extracellular space|platelet alpha granule lumen	enzyme binding|GTPase activator activity|interleukin-1 binding|interleukin-8 binding|serine-type endopeptidase inhibitor activity|tumor necrosis factor binding			central_nervous_system(4)|skin(1)	5					Bacitracin(DB00626)|Becaplermin(DB00102)	TGAGGCCACCCTCTAACTGGA	0.463		NaN											1	0	1.57945e-13	0.011902	1.90048e-13	37	54									
TROAP	10024	broad.mit.edu	37	12	49724403	49724403	+	Missense_Mutation	SNP	A	A	G			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr12:49724403A>G	uc001rtx.3	+	13	1942	c.1775A>G	c.(1774-1776)TAC>TGC	p.Y592C	TROAP_uc009zlh.2_Missense_Mutation_p.Y592C|TROAP_uc001rty.2_Intron	NM_005480	NP_005471	Q12815	TROAP_HUMAN	tastin isoform 1	592	Cys-rich.|4 X 33 AA approximate tandem repeats.|3.				cell adhesion	cytoplasm				ovary(1)	1						CTAGAGTCCTACTGTAGGATT	0.617		NaN											0	0	0	0.001168	0	5	81									
LHX5	64211	broad.mit.edu	37	12	113906970	113906970	+	Missense_Mutation	SNP	G	G	T			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr12:113906970G>T	uc001tvj.1	-	2	928	c.354C>A	c.(352-354)GAC>GAA	p.D118E		NM_022363	NP_071758	Q9H2C1	LHX5_HUMAN	LIM homeobox protein 5	118	LIM zinc-binding 2.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0						AGCTCAGGTAGTCGTCTTTGC	0.572		NaN											1	0	3.86212e-05	0.008291	4.14198e-05	11	13									
C1QTNF9	338872	broad.mit.edu	37	13	24895231	24895231	+	Missense_Mutation	SNP	G	G	T			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr13:24895231G>T	uc001upj.2	+	4	388	c.327G>T	c.(325-327)ATG>ATT	p.M109I	C1QTNF9_uc001upe.2_RNA	NM_178540	NP_848635	P0C862	C1T9A_HUMAN	C1q and tumor necrosis factor related protein 9	109	Collagen-like 2.					collagen	hormone activity				0		all_cancers(29;3.55e-20)|all_epithelial(30;4.25e-17)|all_lung(29;1.04e-16)|Lung SC(185;0.0225)|Breast(139;0.052)		all cancers(112;0.00565)|Epithelial(112;0.027)|OV - Ovarian serous cystadenocarcinoma(117;0.115)|Lung(94;0.159)		CAGGGCCCATGGGAGAGAAGG	0.582		NaN											1	0	3.51602e-12	0.008871	4.0974e-12	20	19									
PCDH20	64881	broad.mit.edu	37	13	61986716	61986716	+	Missense_Mutation	SNP	C	C	A			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr13:61986716C>A	uc001vid.3	-	2	1880	c.1516G>T	c.(1516-1518)GCT>TCT	p.A506S	PCDH20_uc010thj.1_Missense_Mutation_p.A506S	NM_022843	NP_073754	Q8N6Y1	PCD20_HUMAN	protocadherin 20	479	Cadherin 3.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|breast(1)|central_nervous_system(1)	6		Breast(118;0.195)|Prostate(109;0.229)		GBM - Glioblastoma multiforme(99;0.000118)		GCCACCACAGCTACTTCATAG	0.388		NaN											1	0	9.61239e-26	0.01441	1.35489e-25	63	78									
COCH	1690	broad.mit.edu	37	14	31349663	31349663	+	Nonsense_Mutation	SNP	C	C	T			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr14:31349663C>T	uc001wqr.2	+	7	522	c.442C>T	c.(442-444)CGA>TGA	p.R148*	COCH_uc001wqp.2_Nonsense_Mutation_p.R148*|COCH_uc001wqq.3_Nonsense_Mutation_p.R148*|uc001wqs.2_Intron|COCH_uc001wqt.1_Translation_Start_Site	NM_004086	NP_004077	O43405	COCH_HUMAN	cochlin precursor	148					sensory perception of sound	proteinaceous extracellular matrix				pancreas(1)|central_nervous_system(1)|skin(1)	3	Hepatocellular(127;0.0877)|Breast(36;0.148)		LUAD - Lung adenocarcinoma(48;0.00192)|Lung(238;0.0119)|BRCA - Breast invasive adenocarcinoma(188;0.0805)	GBM - Glioblastoma multiforme(265;0.00645)		TTCAGGTAAACGACTAAAGAA	0.413		NaN											0	0	0	0.010729	0	8	12									
FAM71D	161142	broad.mit.edu	37	14	67671305	67671305	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr14:67671305G>A	uc001xja.1	+	5	665	c.411G>A	c.(409-411)ATG>ATA	p.M137I	FAM71D_uc010aqn.1_RNA	NM_173526	NP_775797	Q8N9W8	FA71D_HUMAN	hypothetical protein LOC161142	137										ovary(1)	1		all_hematologic(31;0.0116)		all cancers(60;0.00107)|BRCA - Breast invasive adenocarcinoma(234;0.00993)|OV - Ovarian serous cystadenocarcinoma(108;0.012)		CGGAGAACATGAGCCTGAAAG	0.493		NaN											0	0	0	0.001168	0	4	15									
ZFYVE1	53349	broad.mit.edu	37	14	73459948	73459948	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr14:73459948G>A	uc001xnm.2	-	4	1746	c.1106C>T	c.(1105-1107)ACG>ATG	p.T369M	ZFYVE1_uc010arj.2_Missense_Mutation_p.T369M	NM_021260	NP_067083	Q9HBF4	ZFYV1_HUMAN	zinc finger, FYVE domain containing 1 isoform 1	369						endoplasmic reticulum|Golgi stack|perinuclear region of cytoplasm	1-phosphatidylinositol binding|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|zinc ion binding			skin(1)	1		all_lung(585;1.33e-09)		OV - Ovarian serous cystadenocarcinoma(108;1.6e-46)|BRCA - Breast invasive adenocarcinoma(234;0.00349)		AGAAAAGTCCGTGGGAGGGTT	0.562		NaN											0	0	0	0.01441	0	47	50									
PTPN21	11099	broad.mit.edu	37	14	88983603	88983603	+	Silent	SNP	G	G	A			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr14:88983603G>A	uc001xwv.3	-	3	514	c.183C>T	c.(181-183)GTC>GTT	p.V61V	PTPN21_uc010twc.1_5'UTR|PTPN21_uc010atf.1_Silent_p.V61V	NM_007039	NP_008970	Q16825	PTN21_HUMAN	protein tyrosine phosphatase, non-receptor type	61	FERM.					cytoplasm|cytoskeleton	binding|protein tyrosine phosphatase activity			ovary(3)|skin(1)	4						TGAAGTAAGTGACCTGGAAAG	0.433		NaN											0	0	0	0.006122	0	14	52									
DIO3	1735	broad.mit.edu	37	14	102028171	102028171	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr14:102028171C>T	uc010txq.1	+	1	484	c.260C>T	c.(259-261)TCG>TTG	p.S87L	DIO3OS_uc001ykd.1_5'Flank|uc001yke.2_5'Flank|uc001ykf.2_5'Flank|uc001ykg.2_5'Flank|uc001ykh.3_5'Flank|MIR1247_hsa-mir-1247|MI0006382_5'Flank	NM_001362	NP_001353	P55073	IOD3_HUMAN	deiodinase, iodothyronine, type III	87	Extracellular (Potential).				cellular nitrogen compound metabolic process|hormone biosynthetic process	endosome membrane|integral to membrane|plasma membrane	thyroxine 5'-deiodinase activity|thyroxine 5-deiodinase activity			ovary(1)|central_nervous_system(1)|skin(1)	3		all_neural(303;0.185)				ACCCTGGCGTCGCTCAAGGCG	0.662		NaN											0	0	0	0.001984	0	6	73									
PPP1R13B	23368	broad.mit.edu	37	14	104206397	104206397	+	Missense_Mutation	SNP	C	C	A			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr14:104206397C>A	uc001yof.1	-	12	2639	c.2356G>T	c.(2356-2358)GCC>TCC	p.A786S	PPP1R13B_uc010awv.1_RNA|PPP1R13B_uc001yog.1_Missense_Mutation_p.A653S	NM_015316	NP_056131	Q96KQ4	ASPP1_HUMAN	apoptosis-stimulating protein of p53, 1	786	Pro-rich.				apoptosis|induction of apoptosis|negative regulation of cell cycle	cytoplasm|nucleus|plasma membrane	protein binding			ovary(1)	1		all_cancers(154;0.173)|all_epithelial(191;0.131)|Melanoma(154;0.155)				GATGACGGGGCAGGCTCAGCG	0.602		NaN											1	0	1.4709e-25	0.01441	2.05371e-25	44	83									
VPS39	23339	broad.mit.edu	37	15	42454656	42454656	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr15:42454656C>T	uc001zpd.2	-	23	2383	c.2232G>A	c.(2230-2232)ATG>ATA	p.M744I	VPS39_uc001zpc.2_Missense_Mutation_p.M733I|VPS39_uc001zpb.2_Missense_Mutation_p.M79I	NM_015289	NP_056104	Q96JC1	VPS39_HUMAN	vacuolar protein sorting 39	744					protein transport	HOPS complex|late endosome membrane|lysosomal membrane	small GTPase regulator activity			ovary(1)|pancreas(1)|skin(1)	3		all_cancers(109;6.78e-16)|all_epithelial(112;1.81e-14)|Lung NSC(122;5.01e-09)|all_lung(180;2.24e-08)|Melanoma(134;0.0574)|Colorectal(260;0.152)		GBM - Glioblastoma multiforme(94;3.05e-06)		GCGACAGGTACATCCGAAGCA	0.592		NaN											0	0	0	0.016723	0	12	44									
DMXL2	23312	broad.mit.edu	37	15	51741202	51741202	+	Missense_Mutation	SNP	G	G	T			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr15:51741202G>T	uc002abf.2	-	43	9315	c.9090C>A	c.(9088-9090)AAC>AAA	p.N3030K	DMXL2_uc002abd.2_Missense_Mutation_p.N1122K|DMXL2_uc010ufy.1_Missense_Mutation_p.N3031K|DMXL2_uc010bfa.2_Missense_Mutation_p.N2394K|DMXL2_uc002abc.2_RNA	NM_015263	NP_056078	Q8TDJ6	DMXL2_HUMAN	Dmx-like 2	3030	WD 16.					cell junction|synaptic vesicle membrane	Rab GTPase binding			ovary(6)|skin(3)	9				all cancers(107;0.00494)		CAAGAATTCTGTTAGGGATGT	0.408		NaN											1	0	2.74318e-10	0.006214	3.123e-10	8	22									
SLC24A1	9187	broad.mit.edu	37	15	65918083	65918083	+	Missense_Mutation	SNP	G	G	T			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr15:65918083G>T	uc010ujf.1	+	2	1952	c.1665G>T	c.(1663-1665)TGG>TGT	p.W555C	SLC24A1_uc010ujd.1_Missense_Mutation_p.W555C|SLC24A1_uc010uje.1_Missense_Mutation_p.W555C|SLC24A1_uc010ujg.1_Missense_Mutation_p.W555C|SLC24A1_uc010ujh.1_Missense_Mutation_p.W555C	NM_004727	NP_004718	O60721	NCKX1_HUMAN	solute carrier family 24	555	Cytoplasmic (Potential).				response to light intensity|visual perception	integral to plasma membrane|membrane fraction|outer membrane	calcium, potassium:sodium antiporter activity|protein binding|symporter activity				0						ACCTCACCTGGTGGCCCTTAT	0.522		NaN											1	0	1.21353e-23	0.01441	1.66299e-23	47	65									
CHRNB4	1143	broad.mit.edu	37	15	78922018	78922018	+	Missense_Mutation	SNP	C	C	A			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr15:78922018C>A	uc002bed.1	-	5	741	c.629G>T	c.(628-630)AGG>ATG	p.R210M	CHRNB4_uc002bee.1_Intron|CHRNB4_uc010blh.1_Missense_Mutation_p.R28M	NM_000750	NP_000741	P30926	ACHB4_HUMAN	cholinergic receptor, nicotinic, beta 4	210	Extracellular (Potential).				regulation of neurotransmitter secretion|synaptic transmission involved in micturition|synaptic transmission, cholinergic	cell junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity				0						GTTCACTGTCCTTCTCCCTGG	0.552		NaN											1	0	1.22047e-21	0.01441	1.62729e-21	67	100									
GP2	2813	broad.mit.edu	37	16	20322574	20322574	+	Missense_Mutation	SNP	G	G	T			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr16:20322574G>T	uc002dgv.2	-	12	1668	c.1585C>A	c.(1585-1587)CTG>ATG	p.L529M	GP2_uc002dgw.2_Missense_Mutation_p.L526M|GP2_uc002dgx.2_Missense_Mutation_p.L382M|GP2_uc002dgy.2_Missense_Mutation_p.L379M	NM_001007240	NP_001007241	P55259	GP2_HUMAN	zymogen granule membrane glycoprotein 2 isoform	529						anchored to membrane|extracellular region|plasma membrane				ovary(3)|skin(1)	4						AGGACAGTCAGGAGGACCATA	0.522		NaN											1	0	8.30282e-39	0.01441	1.26682e-38	38	48									
ZNF267	10308	broad.mit.edu	37	16	31927534	31927534	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr16:31927534C>G	uc002ecs.3	+	4	2173	c.1964C>G	c.(1963-1965)ACT>AGT	p.T655S		NM_003414	NP_003405	Q14586	ZN267_HUMAN	zinc finger protein 267	655					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|breast(1)|skin(1)	4						AGAAGTCATACTGGAGAGAGA	0.453		NaN											0	0	0	0.004672	0	3	86									
RPGRIP1L	23322	broad.mit.edu	37	16	53730066	53730066	+	Missense_Mutation	SNP	T	T	A			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr16:53730066T>A	uc002ehp.2	-	3	291	c.227A>T	c.(226-228)AAA>ATA	p.K76I	RPGRIP1L_uc002eho.3_Missense_Mutation_p.K76I|RPGRIP1L_uc010vgy.1_Missense_Mutation_p.K76I|RPGRIP1L_uc010cbx.2_Missense_Mutation_p.K76I|RPGRIP1L_uc010vgz.1_Missense_Mutation_p.K76I|RPGRIP1L_uc002ehq.1_Missense_Mutation_p.K76I|RPGRIP1L_uc010cby.1_Missense_Mutation_p.K76I	NM_015272	NP_056087	Q68CZ1	FTM_HUMAN	RPGRIP1-like isoform a	76	Potential.				negative regulation of G-protein coupled receptor protein signaling pathway	cell-cell junction|centrosome|cilium axoneme|microtubule basal body	thromboxane A2 receptor binding			ovary(1)	1		all_cancers(37;0.0973)				TCATAACCTTTTAATTTTATC	0.323		NaN											0	0	0	0.021022	0	31	47									
CDYL2	124359	broad.mit.edu	37	16	80646693	80646693	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr16:80646693C>T	uc002ffs.2	-	5	1153	c.1048G>A	c.(1048-1050)GTG>ATG	p.V350M		NM_152342	NP_689555	Q8N8U2	CDYL2_HUMAN	chromodomain protein, Y-like 2	350						nucleus	catalytic activity|protein binding			central_nervous_system(1)	1						ATGGCCACCACGATAGGCTTC	0.562		NaN											0	0	0	0.012213	0	27	55									
TP53	7157	broad.mit.edu	37	17	7576855	7576855	+	Nonsense_Mutation	SNP	G	G	A			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr17:7576855G>A	uc002gim.2	-	9	1185	c.991C>T	c.(991-993)CAG>TAG	p.Q331*	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Nonsense_Mutation_p.Q331*|TP53_uc010cne.1_RNA|TP53_uc010cnf.1_Nonsense_Mutation_p.Q199*|TP53_uc010cng.1_Nonsense_Mutation_p.Q199*|TP53_uc002gii.1_Nonsense_Mutation_p.Q199*|TP53_uc010cnh.1_Nonsense_Mutation_p.Q331*|TP53_uc010cni.1_Nonsense_Mutation_p.Q331*|TP53_uc002gij.2_Nonsense_Mutation_p.Q331*	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	331	Oligomerization.|Interaction with HIPK1 (By similarity).|Interaction with CARM1.|Interaction with HIPK2.		Q -> R (in sporadic cancers; somatic mutation).|Q -> P (in sporadic cancers; somatic mutation).|Q -> H (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.Q331*(14)|p.0?(7)|p.Q331P(3)|p.Q331fs*6(1)|p.?(1)|p.Q331Q(1)|p.Q331R(1)|p.Q331H(1)|p.Q331fs*14(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CTTAGTACCTGAAGGGTGAAA	0.448		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			0	0	0	0.008361	0	26	44									
TP53	7157	broad.mit.edu	37	17	7578403	7578403	+	Missense_Mutation	SNP	C	C	A			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08			C	A	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr17:7578403C>A	uc002gim.2	-	5	721	c.527G>T	c.(526-528)TGC>TTC	p.C176F	TP53_uc002gig.1_Missense_Mutation_p.C176F|TP53_uc002gih.2_Missense_Mutation_p.C176F|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.C44F|TP53_uc010cng.1_Missense_Mutation_p.C44F|TP53_uc002gii.1_Missense_Mutation_p.C44F|TP53_uc010cnh.1_Missense_Mutation_p.C176F|TP53_uc010cni.1_Missense_Mutation_p.C176F|TP53_uc002gij.2_Missense_Mutation_p.C176F|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.C83F|TP53_uc002gio.2_Missense_Mutation_p.C44F|TP53_uc010vug.1_Missense_Mutation_p.C137F	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	176	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).	Zinc.	CP -> FS (in a sporadic cancer; somatic mutation).|C -> S (in sporadic cancers; somatic mutation).|C -> R (in sporadic cancers; somatic mutation).|C -> G (in sporadic cancers; somatic mutation).|C -> W (in sporadic cancers; somatic mutation).|C -> Y (in sporadic cancers; somatic mutation).|C -> F (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.C176F(102)|p.C176Y(56)|p.C176S(19)|p.C176W(11)|p.C176R(8)|p.C176fs*71(7)|p.0?(7)|p.C176*(6)|p.C176_R181delCPHHER(3)|p.R174fs*24(3)|p.C176G(3)|p.C176fs*5(3)|p.R175_E180delRCPHHE(3)|p.V173fs*59(2)|p.R174fs*1(2)|p.V157_C176del20(1)|p.K164_P219del(1)|p.C176fs*65(1)|p.C176_P177delCP(1)|p.V173fs*69(1)|p.C176fs*68(1)|p.E171fs*61(1)|p.V173fs*23(1)|p.R174_H178>S(1)|p.C44Y(1)|p.V172_E180delVVRRCPHHE(1)|p.R174_H179delRRCPHH(1)|p.E171fs*1(1)|p.R175_H178>X(1)|p.R42fs*24(1)|p.C83Y(1)|p.C176fs*72(1)|p.R174_C176delRRC(1)|p.H168fs*69(1)|p.R174fs*70(1)|p.C176del(1)|p.E171_H179delEVVRRCPHH(1)|p.R81fs*24(1)|p.R174_E180>K(1)|p.C176fs*6(1)|p.R174fs*3(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		ATGGTGGGGGCAGCGCCTCAC	0.652		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			1	0	1.8453e-21	0.010771	2.43843e-21	31	32									
DNAH9	1770	broad.mit.edu	37	17	11584169	11584169	+	Missense_Mutation	SNP	C	C	A			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr17:11584169C>A	uc002gne.2	+	19	3774	c.3706C>A	c.(3706-3708)CAA>AAA	p.Q1236K	DNAH9_uc010coo.2_Missense_Mutation_p.Q530K	NM_001372	NP_001363	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9 isoform 2	1236	Stem (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			skin(10)|ovary(4)|breast(3)|central_nervous_system(2)|pancreas(1)	20		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		AGAACAGCAGCAATTCTGGGA	0.527		NaN											1	0	0.000978159	0.010729	0.00101949	10	17									
TOP2A	7153	broad.mit.edu	37	17	38564286	38564286	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr17:38564286C>G	uc002huq.2	-	12	1559	c.1433G>C	c.(1432-1434)AGA>ACA	p.R478T	TOP2A_uc002hur.1_Missense_Mutation_p.R119T	NM_001067	NP_001058	P11388	TOP2A_HUMAN	DNA topoisomerase II, alpha isozyme	478					apoptotic chromosome condensation|DNA ligation|DNA repair|DNA topological change|DNA-dependent DNA replication|mitotic cell cycle G2/M transition decatenation checkpoint|mitotic recombination|phosphatidylinositol-mediated signaling|positive regulation of apoptosis|positive regulation of retroviral genome replication|resolution of meiotic recombination intermediates|sister chromatid segregation	cytoplasm|DNA topoisomerase complex (ATP-hydrolyzing)|nucleolus|nucleoplasm|synaptonemal complex	ATP binding|chromatin binding|DNA topoisomerase (ATP-hydrolyzing) activity|DNA-dependent ATPase activity|drug binding|histone deacetylase binding|protein C-terminus binding|protein heterodimerization activity|protein homodimerization activity|protein kinase C binding|sequence-specific DNA binding transcription factor activity|ubiquitin binding			ovary(4)|large_intestine(1)|central_nervous_system(1)|skin(1)	7		Breast(137;0.00328)	STAD - Stomach adenocarcinoma(5;0.00183)		Amsacrine(DB00276)|Ciprofloxacin(DB00537)|Dexrazoxane(DB00380)|Doxorubicin(DB00997)|Enoxacin(DB00467)|Epirubicin(DB00445)|Etoposide(DB00773)|Fleroxacin(DB04576)|Gatifloxacin(DB01044)|Idarubicin(DB01177)|Levofloxacin(DB01137)|Lomefloxacin(DB00978)|Lucanthone(DB04967)|Mitoxantrone(DB01204)|Moxifloxacin(DB00218)|Norfloxacin(DB01059)|Ofloxacin(DB01165)|Pefloxacin(DB00487)|Podofilox(DB01179)|Sparfloxacin(DB01208)|Teniposide(DB00444)|Trovafloxacin(DB00685)|Valrubicin(DB00385)	ATATTTGTCTCTCCCAACCAC	0.428		NaN											0	0	0	0.014323	0	19	37									
EME1	146956	broad.mit.edu	37	17	48452831	48452831	+	Nonsense_Mutation	SNP	G	G	T			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr17:48452831G>T	uc002iqs.1	+	2	335	c.262G>T	c.(262-264)GAA>TAA	p.E88*	MRPL27_uc002iqq.2_5'Flank|MRPL27_uc002iqr.2_5'Flank|EME1_uc010dbp.1_Nonsense_Mutation_p.E88*	NM_152463	NP_689676	Q96AY2	EME1_HUMAN	essential meiotic endonuclease 1 homolog 1	88					DNA recombination|DNA repair	nucleolus	DNA binding|endonuclease activity|metal ion binding|protein binding				0	Breast(11;5.62e-19)		BRCA - Breast invasive adenocarcinoma(22;2.43e-08)			CAGTGAAAGTGAAGATGAAGA	0.463		NaN						Direct_reversal_of_damage|Homologous_recombination					1	0	8.86878e-18	0.01441	1.12186e-17	37	53									
USP32	84669	broad.mit.edu	37	17	58268030	58268030	+	Missense_Mutation	SNP	C	C	A			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr17:58268030C>A	uc002iyo.1	-	29	3822	c.3536G>T	c.(3535-3537)TGT>TTT	p.C1179F	USP32_uc002iyn.1_Missense_Mutation_p.C849F	NM_032582	NP_115971	Q8NFA0	UBP32_HUMAN	ubiquitin specific protease 32	1179					protein deubiquitination|ubiquitin-dependent protein catabolic process	Golgi apparatus|membrane	calcium ion binding|cysteine-type peptidase activity|ubiquitin thiolesterase activity			lung(2)|breast(2)|large_intestine(1)	5	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		Epithelial(12;2.02e-11)|all cancers(12;5.23e-10)|Colorectal(3;0.198)			ATCAATTTTACAGCCTCTGCA	0.393		NaN											1	0	2.77807e-22	0.013114	3.73777e-22	39	55									
SDK2	54549	broad.mit.edu	37	17	71390398	71390398	+	Missense_Mutation	SNP	A	A	G			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr17:71390398A>G	uc010dfm.2	-	26	3658	c.3658T>C	c.(3658-3660)TGG>CGG	p.W1220R	SDK2_uc002jjt.3_Missense_Mutation_p.W379R|SDK2_uc010dfn.2_Missense_Mutation_p.W899R	NM_001144952	NP_001138424	Q58EX2	SDK2_HUMAN	sidekick 2	1220	Fibronectin type-III 7.|Extracellular (Potential).				cell adhesion	integral to membrane				ovary(2)	2						ACCTCGCTCCAGCGCACCAGC	0.652		NaN											0	0	0	0.012319	0	16	16									
ARHGDIA	396	broad.mit.edu	37	17	79826899	79826899	+	Silent	SNP	G	G	A			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr17:79826899G>A	uc002kbp.2	-	5	507	c.468C>T	c.(466-468)TAC>TAT	p.Y156Y	ARHGDIA_uc002kjk.1_Silent_p.Y31Y|ARHGDIA_uc002kbq.2_Silent_p.Y156Y|ARHGDIA_uc002kbr.2_Intron|ARHGDIA_uc002kbs.1_Intron|ARHGDIA_uc002kbt.1_Silent_p.Y156Y|ARHGDIA_uc010dig.1_RNA	NM_004309	NP_004300	P52565	GDIR1_HUMAN	Rho GDP dissociation inhibitor (GDI) alpha	156					anti-apoptosis|cellular component movement|negative regulation of axonogenesis|negative regulation of cell adhesion|nerve growth factor receptor signaling pathway|positive regulation of axonogenesis|regulation of small GTPase mediated signal transduction|Rho protein signal transduction	cytoskeleton|cytosol	GTPase activator activity|identical protein binding|Rho GDP-dissociation inhibitor activity				0	all_neural(118;0.0878)|Ovarian(332;0.12)		BRCA - Breast invasive adenocarcinoma(99;0.013)|OV - Ovarian serous cystadenocarcinoma(97;0.0382)			TCAGGAACTCGTACTCCTCGG	0.652		NaN											0	0	0	0.021523	0	21	24									
NPC1	4864	broad.mit.edu	37	18	21119389	21119389	+	Silent	SNP	G	G	A			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr18:21119389G>A	uc002kum.3	-	19	3115	c.2841C>T	c.(2839-2841)TTC>TTT	p.F947F	NPC1_uc010xaz.1_Silent_p.F680F	NM_000271	NP_000262	O15118	NPC1_HUMAN	Niemann-Pick disease, type C1 precursor	947					autophagy|bile acid metabolic process|cholesterol efflux|cholesterol homeostasis|lysosomal transport	endoplasmic reticulum|integral to plasma membrane|late endosome membrane|lysosomal membrane|nuclear envelope|perinuclear region of cytoplasm	hedgehog receptor activity|protein binding|sterol transporter activity			ovary(2)	2	all_cancers(21;0.000106)|all_epithelial(16;6.57e-07)|Lung NSC(20;0.00166)|all_lung(20;0.00536)|Colorectal(14;0.0202)|Ovarian(20;0.127)					TCACCCAGTCGAAATAATCGT	0.502		NaN											0	0	0	0.00632	0	21	31									
C19orf21	126353	broad.mit.edu	37	19	758421	758421	+	Missense_Mutation	SNP	C	C	T	rs112598403		TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr19:758421C>T	uc002lpo.2	+	2	1558	c.1475C>T	c.(1474-1476)CCG>CTG	p.P492L		NM_173481	NP_775752	Q8IVT2	CS021_HUMAN	hypothetical protein LOC126353	492										upper_aerodigestive_tract(1)	1		Acute lymphoblastic leukemia(61;4.36e-14)|all_hematologic(61;4.84e-09)|Lung NSC(49;0.000145)|all_lung(49;0.000236)|Breast(49;0.0014)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CGGGGATGCCCGCAAGCCAAC	0.632		NaN											0	0	0	0.013726	0	25	4									
ZNF57	126295	broad.mit.edu	37	19	2917961	2917961	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr19:2917961C>T	uc002lwr.2	+	4	1490	c.1342C>T	c.(1342-1344)CAT>TAT	p.H448Y	ZNF57_uc010xha.1_Missense_Mutation_p.H416Y	NM_173480	NP_775751	Q68EA5	ZNF57_HUMAN	zinc finger protein 57	448	C2H2-type 11.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|GBM - Glioblastoma multiforme(1328;0.00161)|STAD - Stomach adenocarcinoma(1328;0.18)		AGAGCAGCTCCATAAATGTGA	0.443		NaN											0	0	0	0.014758	0	5	43									
ZNF57	126295	broad.mit.edu	37	19	2917975	2917975	+	Missense_Mutation	SNP	C	C	A			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr19:2917975C>A	uc002lwr.2	+	4	1504	c.1356C>A	c.(1354-1356)CAC>CAA	p.H452Q	ZNF57_uc010xha.1_Missense_Mutation_p.H420Q	NM_173480	NP_775751	Q68EA5	ZNF57_HUMAN	zinc finger protein 57	452	C2H2-type 11.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|GBM - Glioblastoma multiforme(1328;0.00161)|STAD - Stomach adenocarcinoma(1328;0.18)		AATGTGAACACTGTGGGAAGG	0.428		NaN											1	0	0.00024832	0.009096	0.00026251	4	43									
MUC16	94025	broad.mit.edu	37	19	9085867	9085867	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr19:9085867G>A	uc002mkp.2	-	1	6152	c.5948C>T	c.(5947-5949)TCC>TTC	p.S1983F		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	1983	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						TGGTTGAGTGGACTGTTCAAT	0.478		NaN											0	0	0	0.01441	0	58	34									
ANGPTL6	83854	broad.mit.edu	37	19	10206748	10206748	+	Silent	SNP	G	G	A			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr19:10206748G>A	uc002mmx.1	-	2	610	c.492C>T	c.(490-492)TTC>TTT	p.F164F	ANGPTL6_uc002mmy.1_Silent_p.F164F	NM_031917	NP_114123	Q8NI99	ANGL6_HUMAN	angiopoietin-like 6 precursor	164					angiogenesis|cell differentiation|signal transduction	extracellular space	receptor binding				0			OV - Ovarian serous cystadenocarcinoma(20;3.58e-08)|Epithelial(33;2.5e-05)|all cancers(31;5.96e-05)			CCAGCTCGCGGAACTTGACGT	0.741		NaN											0	0	0	0.008871	0	11	12									
ZNF563	147837	broad.mit.edu	37	19	12429722	12429722	+	Missense_Mutation	SNP	T	T	C			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr19:12429722T>C	uc002mtp.2	-	4	1355	c.1117A>G	c.(1117-1119)ACG>GCG	p.T373A		NM_145276	NP_660319	Q8TA94	ZN563_HUMAN	zinc finger protein 563	373	C2H2-type 9.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						TGAGATAACGTTTTCCCACAC	0.413		NaN											0	0	0	0.00308	0	5	167									
RPL18A	6142	broad.mit.edu	37	19	17972200	17972200	+	Silent	SNP	C	C	A			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr19:17972200C>A	uc002nhp.1	+	2	152	c.117C>A	c.(115-117)GTC>GTA	p.V39V	SNORA68_uc002nhq.1_5'Flank	NM_000980	NP_000971	Q02543	RL18A_HUMAN	ribosomal protein L18a	39					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit	protein binding|RNA binding|structural constituent of ribosome				0						ATCATGTCGTCGCCAAGTCCC	0.552		NaN											1	0	2.32078e-09	0.003163	2.62196e-09	11	9									
ZNF536	9745	broad.mit.edu	37	19	31040189	31040189	+	Silent	SNP	G	G	T			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr19:31040189G>T	uc002nsu.1	+	4	3801	c.3663G>T	c.(3661-3663)CTG>CTT	p.L1221L	ZNF536_uc010edd.1_Silent_p.L1221L	NM_014717	NP_055532	O15090	ZN536_HUMAN	zinc finger protein 536	1221					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(7)|large_intestine(2)|skin(2)	11	Esophageal squamous(110;0.0834)					TCCAGGGACTGGTCTCACCTT	0.647		NaN											1	0	4.62619e-21	0.019004	6.05908e-21	25	26									
ZNF573	126231	broad.mit.edu	37	19	38262256	38262256	+	Silent	SNP	C	C	T			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr19:38262256C>T	uc002ohe.2	-	2	172	c.150G>A	c.(148-150)AGG>AGA	p.R50R	ZNF573_uc010efs.2_5'UTR|ZNF573_uc002ohd.2_Silent_p.R48R|ZNF573_uc002ohf.2_5'UTR|ZNF573_uc002ohg.2_5'UTR	NM_152360	NP_689573	Q86YE8	ZN573_HUMAN	zinc finger protein 573	30	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1			UCEC - Uterine corpus endometrioid carcinoma (49;0.0775)|Lung(45;0.0813)|LUSC - Lung squamous cell carcinoma(53;0.146)			TGTATAAGTCCCTCTGATTAG	0.418		NaN											0	0	0	0.006122	0	16	24									
RYR1	6261	broad.mit.edu	37	19	38966040	38966040	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr19:38966040G>A	uc002oit.2	+	29	4373	c.4243G>A	c.(4243-4245)GTG>ATG	p.V1415M	RYR1_uc002oiu.2_Missense_Mutation_p.V1415M	NM_000540	NP_000531	P21817	RYR1_HUMAN	skeletal muscle ryanodine receptor isoform 1	1415	Cytoplasmic.|B30.2/SPRY 3.|6 X approximate repeats.				muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(7)|pancreas(2)|breast(1)|central_nervous_system(1)|skin(1)	12	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	TCACGACGTGGTGCCTGCAGA	0.607		NaN											0	0	0	0.016522	0	19	30									
GRIK5	2901	broad.mit.edu	37	19	42526200	42526200	+	Missense_Mutation	SNP	C	C	A			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr19:42526200C>A	uc002osj.1	-	13	1631	c.1596G>T	c.(1594-1596)AAG>AAT	p.K532N	GRIK5_uc002osi.1_Missense_Mutation_p.K104N|GRIK5_uc010eib.1_Missense_Mutation_p.K451N	NM_002088	NP_002079	Q16478	GRIK5_HUMAN	glutamate receptor KA2 precursor	532	Extracellular (Potential).					cell junction|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity				0		Prostate(69;0.059)			L-Glutamic Acid(DB00142)	AGTAGCCAGGCTTGCGGCCCT	0.652		NaN											1	0	6.31663e-08	0.003163	6.97657e-08	13	18									
NOVA2	4858	broad.mit.edu	37	19	46443268	46443268	+	Silent	SNP	C	C	T			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr19:46443268C>T	uc002pdv.2	-	4	1380	c.1332G>A	c.(1330-1332)AAG>AAA	p.K444K		NM_002516	NP_002507	Q9UNW9	NOVA2_HUMAN	neuro-oncological ventral antigen 2	444	KH 3.					nucleus	RNA binding				0		all_neural(266;0.113)|Ovarian(192;0.127)		OV - Ovarian serous cystadenocarcinoma(262;0.00245)|GBM - Glioblastoma multiforme(486;0.0782)|Epithelial(262;0.179)		ACTCGCCCTTCTTGGAGATCT	0.657		NaN											0	0	0	0.01441	0	68	118									
ZNF845	91664	broad.mit.edu	37	19	53855364	53855365	+	Missense_Mutation	DNP	CA	CA	TG			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr19:53855364_53855365CA>TG	uc010ydv.1	+	4	1553_1554	c.1436_1437CA>TG	c.(1435-1437)ACA>ATG	p.T479M	ZNF845_uc010ydw.1_Missense_Mutation_p.T479M	NM_138374	NP_612383	Q96IR2	ZN845_HUMAN	zinc finger protein 845	479	C2H2-type 10.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						TTCAGTCAGACATCATCCCTTG	0.381		NaN											0	0	0	0.004672	0	4	94									
ZNF761	388561	broad.mit.edu	37	19	53958879	53958879	+	Missense_Mutation	SNP	A	A	G	rs147132093		TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr19:53958879A>G	uc010eqp.2	+	7	1576	c.1118A>G	c.(1117-1119)CAT>CGT	p.H373R	ZNF761_uc010ydy.1_Missense_Mutation_p.H319R|ZNF761_uc002qbt.1_Missense_Mutation_p.H319R	NM_001008401	NP_001008401	Q86XN6	ZN761_HUMAN	zinc finger protein 761	373	C2H2-type 6.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1				GBM - Glioblastoma multiforme(134;0.00786)		ACATGCCATCATAGACTTCAT	0.428		NaN											0	0	0	0.008291	0	8	232									
ZNF761	388561	broad.mit.edu	37	19	53958910	53958910	+	Silent	SNP	A	A	G			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr19:53958910A>G	uc010eqp.2	+	7	1607	c.1149A>G	c.(1147-1149)AAA>AAG	p.K383K	ZNF761_uc010ydy.1_Silent_p.K329K|ZNF761_uc002qbt.1_Silent_p.K329K	NM_001008401	NP_001008401	Q86XN6	ZN761_HUMAN	zinc finger protein 761	383	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1				GBM - Glioblastoma multiforme(134;0.00786)		AACCCTACAAATGTAATGAGT	0.413		NaN											0	0	0	0.006214	0	5	227									
NLRP11	204801	broad.mit.edu	37	19	56297208	56297208	+	Missense_Mutation	SNP	G	G	T			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr19:56297208G>T	uc010ygf.1	-	12	3596	c.2885C>A	c.(2884-2886)ACC>AAC	p.T962N	NLRP11_uc002qlz.2_Missense_Mutation_p.T809N|NLRP11_uc002qmb.2_Missense_Mutation_p.T863N|NLRP11_uc002qmc.2_RNA	NM_145007	NP_659444	P59045	NAL11_HUMAN	NLR family, pyrin domain containing 11	962							ATP binding			ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	6		Colorectal(82;0.0002)		GBM - Glioblastoma multiforme(193;0.0325)		CAACTGCTGGGTTTGTGTGTT	0.433		NaN											1	0	0.00074312	0.006122	0.000780013	18	28									
C2orf42	54980	broad.mit.edu	37	2	70392226	70392226	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr2:70392226C>T	uc002sgh.2	-	8	1679	c.1351G>A	c.(1351-1353)GAG>AAG	p.E451K		NM_017880	NP_060350	Q9NWW7	CB042_HUMAN	hypothetical protein LOC54980	451											0						ACTCTCACCTCTGGGGTATCT	0.428		NaN											0	0	0	0.01441	0	44	55									
C2orf42	54980	broad.mit.edu	37	2	70392294	70392294	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr2:70392294C>G	uc002sgh.2	-	8	1611	c.1283G>C	c.(1282-1284)GGA>GCA	p.G428A		NM_017880	NP_060350	Q9NWW7	CB042_HUMAN	hypothetical protein LOC54980	428											0						GGAAAAGGTTCCCAGTGGCAA	0.353		NaN											0	0	0	0.009535	0	28	30									
ZNF638	27332	broad.mit.edu	37	2	71651159	71651159	+	Missense_Mutation	SNP	C	C	A			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr2:71651159C>A	uc002shx.2	+	22	4834	c.4515C>A	c.(4513-4515)AGC>AGA	p.S1505R	ZNF638_uc010yqw.1_Missense_Mutation_p.S1084R|ZNF638_uc002shy.2_Missense_Mutation_p.S1505R|ZNF638_uc002shz.2_Missense_Mutation_p.S1505R|ZNF638_uc002sia.2_Missense_Mutation_p.S1505R|ZNF638_uc002sib.1_Intron|ZNF638_uc010fed.2_Intron|ZNF638_uc002sic.2_Missense_Mutation_p.S602R|ZNF638_uc002sid.2_Intron	NM_014497	NP_055312	Q14966	ZN638_HUMAN	zinc finger protein 638	1505					RNA splicing	cytoplasm|nuclear speck	double-stranded DNA binding|nucleotide binding|RNA binding|zinc ion binding			pancreas(2)|ovary(1)|skin(1)	4						GGGATGACAGCAACAATAAGG	0.433		NaN											1	0	8.28177e-16	0.007413	1.02142e-15	15	28									
C2orf3	6936	broad.mit.edu	37	2	75915023	75915023	+	Silent	SNP	C	C	T			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr2:75915023C>T	uc002sno.2	-	11	1750	c.1620G>A	c.(1618-1620)AAG>AAA	p.K540K	C2orf3_uc010ffs.2_Silent_p.K102K|C2orf3_uc002snn.2_Silent_p.K371K|C2orf3_uc010fft.2_Silent_p.K215K	NM_003203	NP_003194	P16383	GCF_HUMAN	hypothetical protein LOC6936	540					negative regulation of transcription, DNA-dependent	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(1)|central_nervous_system(1)	2						TACTTTCCTTCTTTGAATCTT	0.338		NaN											0	0	0	0.00499	0	15	35									
CTNNA2	1496	broad.mit.edu	37	2	80101255	80101255	+	Silent	SNP	G	G	A			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr2:80101255G>A	uc010ysh.1	+	5	644	c.639G>A	c.(637-639)CTG>CTA	p.L213L	CTNNA2_uc010yse.1_Silent_p.L213L|CTNNA2_uc010ysf.1_Silent_p.L213L|CTNNA2_uc010ysg.1_Silent_p.L213L	NM_004389	NP_004380	P26232	CTNA2_HUMAN	catenin, alpha 2 isoform 1	213					axonogenesis|brain morphogenesis|cell-cell adhesion|dendrite morphogenesis|muscle cell differentiation|positive regulation of muscle cell differentiation|prepulse inhibition|radial glia guided migration of Purkinje cell|regulation of synapse structural plasticity	actin cytoskeleton|axon|cytosol	cadherin binding|structural constituent of cytoskeleton			pancreas(4)|lung(3)|breast(1)|skin(1)	9						GAGGGGCTCTGAAGAAGAATG	0.517		NaN											0	0	0	0.007291	0	26	23									
MFSD9	84804	broad.mit.edu	37	2	103353184	103353184	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr2:103353184C>T	uc002tcb.2	-	1	154	c.86G>A	c.(85-87)GGA>GAA	p.G29E	TMEM182_uc002tcc.3_5'Flank|TMEM182_uc002tcd.3_5'Flank|MFSD9_uc010fja.2_RNA	NM_032718	NP_116107	Q8NBP5	MFSD9_HUMAN	major facilitator superfamily domain containing	29					transmembrane transport	integral to membrane|plasma membrane	transporter activity			ovary(2)|breast(2)	4						CGCCTCGGTTCCTGTCTTCTG	0.677		NaN											0	0	0	0.012319	0	22	28									
TFCP2L1	29842	broad.mit.edu	37	2	122038802	122038802	+	Silent	SNP	C	C	A			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr2:122038802C>A	uc002tmx.2	-	2	201	c.108G>T	c.(106-108)CTG>CTT	p.L36L	TFCP2L1_uc010flr.2_Silent_p.L36L	NM_014553	NP_055368	Q9NZI6	TF2L1_HUMAN	LBP-9	36	Mediate transcriptional repression.				female pregnancy|steroid biosynthetic process	mitochondrion|nucleolus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			pancreas(2)|ovary(1)	3	Renal(3;0.01)					TCTCGGGGGACAGCTGGGGTT	0.622		NaN											1	0	6.20995e-33	0.01441	9.09973e-33	63	115									
SCN1A	6323	broad.mit.edu	37	2	166848518	166848518	+	Missense_Mutation	SNP	C	C	A			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr2:166848518C>A	uc010zcz.1	-	26	5252	c.5234G>T	c.(5233-5235)TGT>TTT	p.C1745F		NM_006920	NP_008851	P35498	SCN1A_HUMAN	sodium channel, voltage-gated, type I, alpha	1756	IV.					voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|skin(6)|large_intestine(1)	13					Lamotrigine(DB00555)|Levetiracetam(DB01202)|Phenacemide(DB01121)|Phenytoin(DB00252)|Topiramate(DB00273)|Zonisamide(DB00909)	TGGGTTCCCACAGTCTCCCTT	0.468		NaN											1	0	1.07363e-35	0.01441	1.60502e-35	60	105									
XIRP2	129446	broad.mit.edu	37	2	168105238	168105238	+	Missense_Mutation	SNP	C	C	A			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr2:168105238C>A	uc002udx.2	+	8	7354	c.7336C>A	c.(7336-7338)CTG>ATG	p.L2446M	XIRP2_uc010fpn.2_Intron|XIRP2_uc010fpo.2_Intron|XIRP2_uc010fpp.2_Intron|XIRP2_uc002udy.2_Missense_Mutation_p.L2271M|XIRP2_uc010fpq.2_Missense_Mutation_p.L2224M|XIRP2_uc010fpr.2_Intron|XIRP2_uc010fps.1_Intron	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	2271					actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14						CAAAGTTGAACTGGCAACCTC	0.423		NaN											1	0	9.58827e-17	0.01441	1.19249e-16	41	59									
NFE2L2	4780	broad.mit.edu	37	2	178098945	178098945	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08			G	C	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr2:178098945G>C	uc002ulh.3	-	2	655	c.100C>G	c.(100-102)CGA>GGA	p.R34G	NFE2L2_uc002ulg.3_Missense_Mutation_p.R18G|NFE2L2_uc010zfa.1_Missense_Mutation_p.R18G|NFE2L2_uc002uli.3_Missense_Mutation_p.R18G|NFE2L2_uc010fra.2_Missense_Mutation_p.R18G|NFE2L2_uc010frb.2_Missense_Mutation_p.R18G	NM_006164	NP_006155	Q16236	NF2L2_HUMAN	nuclear factor erythroid 2-like 2 isoform 1	34					transcription from RNA polymerase II promoter	centrosome|cytosol|nucleus|plasma membrane	protein dimerization activity|protein domain specific binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)	1			Epithelial(96;0.00442)|OV - Ovarian serous cystadenocarcinoma(117;0.00739)|all cancers(119;0.0195)|LUSC - Lung squamous cell carcinoma(2;0.036)|Lung(16;0.0935)			AATACTTCTCGACTTACTCCA	0.368		NaN	Mis		NSCLC|HNSCC					HNSCC(56;0.16)			0	0	0	0.007413	0	18	7									
EEF1B2	1933	broad.mit.edu	37	2	207026135	207026135	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr2:207026135G>C	uc002vbf.1	+	4	427	c.269G>C	c.(268-270)AGT>ACT	p.S90T	NDUFS1_uc010ziq.1_5'Flank|NDUFS1_uc002vbe.2_5'Flank|NDUFS1_uc010zir.1_5'Flank|NDUFS1_uc010zis.1_5'Flank|NDUFS1_uc010zit.1_5'Flank|NDUFS1_uc010ziu.1_5'Flank|EEF1B2_uc002vbg.1_Missense_Mutation_p.S90T|EEF1B2_uc002vbh.1_Missense_Mutation_p.S90T|SNORD51_uc002vbi.1_5'Flank|SNORA41_uc002vbj.2_5'Flank	NM_001037663	NP_001032752	P24534	EF1B_HUMAN	eukaryotic translation elongation factor 1 beta	90						cytosol|eukaryotic translation elongation factor 1 complex	protein binding|translation elongation factor activity				0						ACTACAGGAAGTGGAGCTACA	0.393		NaN											0	0	0	0.01441	0	58	80									
PCNT	5116	broad.mit.edu	37	21	47769714	47769714	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr21:47769714G>A	uc002zji.3	+	8	1431	c.1324G>A	c.(1324-1326)GAG>AAG	p.E442K	PCNT_uc002zjj.2_Missense_Mutation_p.E324K|PCNT_uc010gqk.1_RNA	NM_006031	NP_006022	O95613	PCNT_HUMAN	pericentrin	442	Glu-rich.|Potential.				cilium assembly|G2/M transition of mitotic cell cycle	cytosol|microtubule	calmodulin binding			ovary(4)|breast(2)|pancreas(2)	8	Breast(49;0.112)					CAAAGAGAGCGAGAAAGAAAA	0.433		NaN											0	0	0	0.007291	0	21	35									
HIRA	7290	broad.mit.edu	37	22	19393309	19393309	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr22:19393309C>T	uc002zpf.1	-	5	617	c.397G>A	c.(397-399)GAT>AAT	p.D133N	HIRA_uc011agx.1_5'UTR|HIRA_uc010grn.1_Missense_Mutation_p.D133N|HIRA_uc010gro.1_Missense_Mutation_p.D89N|HIRA_uc010grp.2_RNA	NM_003325	NP_003316	P54198	HIRA_HUMAN	HIR histone cell cycle regulation defective	133	WD 3.				chromatin modification|regulation of transcription from RNA polymerase II promoter	PML body	chromatin binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			ovary(1)	1	Colorectal(54;0.0993)					TCCCACTCACCGCCTGAATGA	0.607		NaN											0	0	0	0.01892	0	22	37									
PIWIL3	440822	broad.mit.edu	37	22	25131817	25131817	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr22:25131817C>T	uc003abd.1	-	13	1909	c.1492G>A	c.(1492-1494)GAA>AAA	p.E498K	PIWIL3_uc011ajx.1_Missense_Mutation_p.E389K|PIWIL3_uc011ajy.1_Missense_Mutation_p.E389K|PIWIL3_uc010gut.1_Missense_Mutation_p.E498K	NM_001008496	NP_001008496	Q7Z3Z3	PIWL3_HUMAN	piwi-like 3	498					cell differentiation|gene silencing by RNA|meiosis|multicellular organismal development|regulation of translation|spermatogenesis	cytoplasm	RNA binding			ovary(3)|central_nervous_system(1)	4						AAGGGTAATTCTCTTATTTCT	0.373		NaN											0	0	0	0.01441	0	37	87									
CCDC157	550631	broad.mit.edu	37	22	30772567	30772567	+	Missense_Mutation	SNP	T	T	C			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr22:30772567T>C	uc011aku.1	+	12	2752	c.2092T>C	c.(2092-2094)TCT>CCT	p.S698P	CCDC157_uc011akv.1_Missense_Mutation_p.S698P|uc003aho.1_5'Flank	NM_001017437	NP_001017437	Q569K6	CC157_HUMAN	coiled-coil domain containing 157	698										central_nervous_system(1)	1						CACATCCCCATCTCGGCAGCC	0.667		NaN											0	0	0	0.010729	0	7	281									
ISX	91464	broad.mit.edu	37	22	35463109	35463109	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr22:35463109G>A	uc003anj.2	+	1	980	c.29G>A	c.(28-30)TGC>TAC	p.C10Y	ISX_uc011amg.1_5'UTR	NM_001008494	NP_001008494	Q2M1V0	ISX_HUMAN	intestine-specific homeobox	10						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(3)|skin(2)	5						CCTGCTCTCTGCAGGGGTATG	0.602		NaN											0	0	0	0.00632	0	22	24									
SH3BP1	23616	broad.mit.edu	37	22	38061710	38061710	+	Missense_Mutation	SNP	G	G	T			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr22:38061710G>T	uc003atj.1	+	17	2537	c.1650G>T	c.(1648-1650)GAG>GAT	p.E550D	PDXP_uc003atm.1_Missense_Mutation_p.E241D			Q9Y3L3	3BP1_HUMAN	SubName: Full=cDNA FLJ44925 fis, clone BRAMY3014613, highly similar to Homo sapiens SH3-domain binding protein 1 (SH3BP1);	Error:Variant_position_missing_in_Q9Y3L3_after_alignment					signal transduction	cytoplasm	GTPase activator activity|SH3 domain binding			central_nervous_system(1)	1	Melanoma(58;0.0574)					ACCGCCTGGAGACCGACATCC	0.647		NaN											1	0	2.16659e-41	0.01441	3.34016e-41	68	150									
TGFBR2	7048	broad.mit.edu	37	3	30715617	30715617	+	Missense_Mutation	SNP	G	G	T			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr3:30715617G>T	uc003ceo.2	+	5	1657	c.1275G>T	c.(1273-1275)ATG>ATT	p.M425I	TGFBR2_uc003cen.2_Missense_Mutation_p.M450I	NM_003242	NP_003233	P37173	TGFR2_HUMAN	transforming growth factor, beta receptor II	425	Protein kinase.|Cytoplasmic (Potential).				activation of protein kinase activity|brain development|embryonic cranial skeleton morphogenesis|embryonic hemopoiesis|heart development|myeloid dendritic cell differentiation|palate development|pathway-restricted SMAD protein phosphorylation|patterning of blood vessels|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of B cell tolerance induction|positive regulation of mesenchymal cell proliferation|positive regulation of NK T cell differentiation|positive regulation of reactive oxygen species metabolic process|positive regulation of T cell tolerance induction|positive regulation of tolerance induction to self antigen|response to cholesterol|response to drug|transforming growth factor beta receptor signaling pathway|transforming growth factor beta receptor signaling pathway|vasculogenesis	caveola|external side of plasma membrane	ATP binding|glycosaminoglycan binding|metal ion binding|protein binding|receptor signaling protein serine/threonine kinase activity|SMAD binding|transforming growth factor beta binding|transforming growth factor beta receptor activity, type II|type I transforming growth factor beta receptor binding|type I transforming growth factor beta receptor binding|type III transforming growth factor beta receptor binding			pancreas(9)|large_intestine(6)|stomach(4)|lung(3)|ovary(3)|central_nervous_system(1)	26						CAAGATACATGGCTCCAGAAG	0.453		NaN											1	0	6.53348e-20	0.017118	8.48206e-20	26	6									
C3orf67	200844	broad.mit.edu	37	3	58849547	58849547	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr3:58849547C>T	uc003dkt.1	-	12	1364	c.955G>A	c.(955-957)GGT>AGT	p.G319S	C3orf67_uc003dks.1_Missense_Mutation_p.G134S|uc003dku.1_Intron|C3orf67_uc003dkv.1_Missense_Mutation_p.G134S|C3orf67_uc003dkw.2_Missense_Mutation_p.G214S	NM_198463	NP_940865	Q6ZVT6	CC067_HUMAN	hypothetical protein LOC200844	319											0		all_cancers(2;0.000156)|all_epithelial(2;0.000493)|Breast(2;0.00446)|all_lung(2;0.074)|Lung NSC(2;0.248)		BRCA - Breast invasive adenocarcinoma(55;5.93e-06)|Kidney(10;0.00155)|KIRC - Kidney renal clear cell carcinoma(10;0.00172)|OV - Ovarian serous cystadenocarcinoma(275;0.23)		GAGTCATCACCCAGAAGTAGA	0.463		NaN											0	0	0	0.007835	0	39	3									
TOPBP1	11073	broad.mit.edu	37	3	133341937	133341937	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr3:133341937C>G	uc003eps.2	-	19	3308	c.3176G>C	c.(3175-3177)GGA>GCA	p.G1059A	TOPBP1_uc003ept.1_Missense_Mutation_p.G63A	NM_007027	NP_008958	Q92547	TOPB1_HUMAN	topoisomerase (DNA) II binding protein 1	1059					DNA repair|response to ionizing radiation	microtubule organizing center|PML body|spindle pole	DNA binding|protein C-terminus binding			ovary(2)|kidney(2)|skin(1)|lung(1)|pancreas(1)	7						tattttaCCTCCTTTAGAGTC	0.229		NaN						Other_conserved_DNA_damage_response_genes					0	0	0	0.008291	0	8	0									
HRG	3273	broad.mit.edu	37	3	186389456	186389456	+	Missense_Mutation	SNP	G	G	T			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr3:186389456G>T	uc003fqq.2	+	4	459	c.436G>T	c.(436-438)GAT>TAT	p.D146Y		NM_000412	NP_000403	P04196	HRG_HUMAN	histidine-rich glycoprotein precursor	146	Cystatin 2.				fibrinolysis|platelet activation|platelet degranulation	extracellular region|plasma membrane|platelet alpha granule lumen	cysteine-type endopeptidase inhibitor activity|heparin binding			ovary(1)|central_nervous_system(1)	2	all_cancers(143;6.64e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;5.73e-20)	GBM - Glioblastoma multiforme(93;0.0683)		GGTCCTCATAGATTTCTTTGA	0.453		NaN											1	0	1.06801e-11	0.009535	1.23489e-11	28	26									
PCYT1A	5130	broad.mit.edu	37	3	195975136	195975136	+	Silent	SNP	G	G	A			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr3:195975136G>A	uc003fwg.2	-	5	449	c.276C>T	c.(274-276)CAC>CAT	p.H92H	PCYT1A_uc003fwh.2_Silent_p.H92H	NM_005017	NP_005008	P49585	PCY1A_HUMAN	choline phosphate cytidylyltransferase 1 alpha	92	Catalytic (Potential).					cytosol|soluble fraction	choline-phosphate cytidylyltransferase activity				0	all_cancers(143;1.19e-08)|Ovarian(172;0.0634)|Breast(254;0.206)		Epithelial(36;1.28e-24)|all cancers(36;1.01e-22)|OV - Ovarian serous cystadenocarcinoma(49;3.88e-19)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00259)	Choline(DB00122)	GAGCTCGGGCGTGACCAGAGT	0.413		NaN											0	0	0	0.001168	0	4	107									
UGT2B4	7363	broad.mit.edu	37	4	70355258	70355258	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr4:70355258C>T	uc003hek.3	-	3	948	c.901G>A	c.(901-903)GAA>AAA	p.E301K	UGT2B4_uc011cap.1_Missense_Mutation_p.E165K|UGT2B4_uc003hel.3_Missense_Mutation_p.E301K	NM_021139	NP_066962	P06133	UD2B4_HUMAN	UDP glucuronosyltransferase 2B4 precursor	301					estrogen catabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			skin(2)	2						ACACCATTTTCTCCAGAGCTC	0.403		NaN											0	0	0	0.01441	0	69	16									
MAPK10	5602	broad.mit.edu	37	4	87022213	87022213	+	Missense_Mutation	SNP	T	T	G			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr4:87022213T>G	uc003hpq.2	-	7	789	c.722A>C	c.(721-723)AAG>ACG	p.K241T	MAPK10_uc010ikg.2_Missense_Mutation_p.K203T|MAPK10_uc003hpr.2_Missense_Mutation_p.K203T|MAPK10_uc003hps.2_Missense_Mutation_p.K241T|MAPK10_uc003hpt.2_Missense_Mutation_p.K241T|MAPK10_uc003hpu.2_Missense_Mutation_p.K241T|MAPK10_uc003hpv.2_Missense_Mutation_p.K96T|MAPK10_uc003hpn.2_5'Flank|MAPK10_uc003hpo.2_Missense_Mutation_p.K96T|MAPK10_uc011ccw.1_Missense_Mutation_p.K127T|MAPK10_uc003hpp.2_Missense_Mutation_p.K96T	NM_138982	NP_620448	P53779	MK10_HUMAN	mitogen-activated protein kinase 10 isoform 2	241	Protein kinase.				innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|regulation of sequence-specific DNA binding transcription factor activity|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|JUN kinase activity|MAP kinase kinase activity|protein binding			stomach(1)|breast(1)|central_nervous_system(1)	3		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.243)		OV - Ovarian serous cystadenocarcinoma(123;0.002)		ACCGTTCTCCTTGTAGCCCAT	0.498		NaN											0	0	0	0.01441	0	39	11									
EGF	1950	broad.mit.edu	37	4	110884383	110884383	+	Missense_Mutation	SNP	C	C	A	rs150311153	byFrequency	TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr4:110884383C>A	uc003hzy.3	+	9	1819	c.1367C>A	c.(1366-1368)CCA>CAA	p.P456Q	EGF_uc011cfu.1_Missense_Mutation_p.P414Q|EGF_uc011cfv.1_Missense_Mutation_p.P456Q	NM_001963	NP_001954	P01133	EGF_HUMAN	epidermal growth factor precursor	456	EGF-like 4.|Extracellular (Potential).				angiogenesis|DNA replication|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of secretion|platelet activation|platelet degranulation|positive regulation of catenin import into nucleus|positive regulation of epidermal growth factor receptor activity|positive regulation of MAP kinase activity|positive regulation of mitosis|regulation of calcium ion import|regulation of protein localization at cell surface	integral to membrane|plasma membrane|platelet alpha granule lumen	calcium ion binding|epidermal growth factor receptor binding|growth factor activity|transmembrane receptor protein tyrosine kinase activator activity			ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	4		Hepatocellular(203;0.0893)		OV - Ovarian serous cystadenocarcinoma(123;9.87e-06)	Sulindac(DB00605)	CCTCTTAGCCCAGTATCCTGG	0.448		NaN											1	0	8.84886e-50	0.01441	1.39323e-49	83	19									
DCLK2	166614	broad.mit.edu	37	4	151023702	151023702	+	Missense_Mutation	SNP	G	G	T			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr4:151023702G>T	uc003ilm.3	+	2	594	c.494G>T	c.(493-495)TGG>TTG	p.W165L	DCLK2_uc003iln.3_Missense_Mutation_p.W165L|DCLK2_uc003ilo.3_Missense_Mutation_p.W165L|DCLK2_uc003ilp.3_RNA	NM_001040260	NP_001035350	Q8N568	DCLK2_HUMAN	doublecortin-like kinase 2 isoform a	165					intracellular signal transduction	cytoplasm|cytoskeleton	ATP binding|protein serine/threonine kinase activity			ovary(3)	3	all_hematologic(180;0.151)					AATCCAAACTGGTCTGTGAAC	0.393		NaN											1	0	2.19489e-29	0.00623	3.15382e-29	29	4									
SLC6A19	340024	broad.mit.edu	37	5	1219713	1219713	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr5:1219713C>T	uc003jbw.3	+	10	1528	c.1472C>T	c.(1471-1473)TCC>TTC	p.S491F		NM_001003841	NP_001003841	Q695T7	S6A19_HUMAN	solute carrier family 6, member 19	491	Helical; Name=10; (Potential).				cellular nitrogen compound metabolic process	integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity				0	all_cancers(3;3.55e-15)|Lung NSC(6;2.89e-14)|all_lung(6;2.2e-13)|all_epithelial(6;3.75e-10)		Epithelial(17;0.000356)|all cancers(22;0.00137)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|Lung(60;0.185)			TATGCCGGCTCCATTCCCCTG	0.592		NaN											0	0	0	0.010818	0	30	80									
ADAMTS12	81792	broad.mit.edu	37	5	33614431	33614431	+	Missense_Mutation	SNP	C	C	A			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr5:33614431C>A	uc003jia.1	-	16	2602	c.2439G>T	c.(2437-2439)CAG>CAT	p.Q813H	ADAMTS12_uc010iuq.1_Missense_Mutation_p.Q728H	NM_030955	NP_112217	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1	813	Spacer 1.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|kidney(1)	9						GGCCATCTTTCTGGATTGTGT	0.478		NaN								HNSCC(64;0.19)			1	0	3.1745e-13	0.008361	3.7586e-13	21	72									
CMYA5	202333	broad.mit.edu	37	5	79027444	79027444	+	Silent	SNP	G	G	T			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr5:79027444G>T	uc003kgc.2	+	2	2928	c.2856G>T	c.(2854-2856)GTG>GTT	p.V952V		NM_153610	NP_705838	Q8N3K9	CMYA5_HUMAN	cardiomyopathy associated 5	952						perinuclear region of cytoplasm				ovary(6)|pancreas(2)|lung(1)	9		Lung NSC(167;0.00296)|all_lung(232;0.00327)|Ovarian(174;0.0262)		OV - Ovarian serous cystadenocarcinoma(54;9.85e-46)|Epithelial(54;3.38e-40)|all cancers(79;3.43e-35)		CTGCATTTGTGTCAGAATTCT	0.393		NaN											1	0	1.64293e-13	0.01892	1.96092e-13	20	2									
EPB41L4A	64097	broad.mit.edu	37	5	111576460	111576460	+	Nonsense_Mutation	SNP	G	G	T			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr5:111576460G>T	uc003kpv.1	-	10	1117	c.843C>A	c.(841-843)TGC>TGA	p.C281*		NM_022140	NP_071423	Q9HCS5	E41LA_HUMAN	erythrocyte protein band 4.1-like 4	281	FERM.					cytoplasm|cytoskeleton|extrinsic to membrane	cytoskeletal protein binding			ovary(1)	1		all_cancers(142;4.93e-06)|all_epithelial(76;2.28e-08)|Prostate(80;0.000244)|Colorectal(10;0.000788)|Ovarian(225;0.0448)|Lung NSC(167;0.126)|all_lung(232;0.135)		OV - Ovarian serous cystadenocarcinoma(64;6.24e-09)|Epithelial(69;1.43e-07)|all cancers(49;2.78e-05)|COAD - Colon adenocarcinoma(37;0.0467)|Colorectal(14;0.0791)		AGAGGTGCTTGCAAGCAGTTT	0.343		NaN											1	0	1.48458e-05	0.017118	1.61557e-05	24	6									
TNXB	7148	broad.mit.edu	37	6	32029938	32029938	+	Silent	SNP	C	C	A			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr6:32029938C>A	uc003nzl.2	-	20	7366	c.7164G>T	c.(7162-7164)GTG>GTT	p.V2388V		NM_019105	NP_061978	P22105	TENX_HUMAN	tenascin XB isoform 1 precursor	2450					actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding				0						ACTCACCTGTCACCCCGATGG	0.627		NaN											1	0	3.45872e-05	0.004007	3.73642e-05	14	16									
CDKN1A	1026	broad.mit.edu	37	6	36652020	36652020	+	Nonsense_Mutation	SNP	C	C	T			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr6:36652020C>T	uc003omm.3	+	2	264	c.142C>T	c.(142-144)CGA>TGA	p.R48*	CDKN1A_uc011dtq.1_Nonsense_Mutation_p.R82*|CDKN1A_uc003oml.2_Nonsense_Mutation_p.R48*|CDKN1A_uc003omn.2_Nonsense_Mutation_p.R48*	NM_000389	NP_000380	P38936	CDN1A_HUMAN	cyclin-dependent kinase inhibitor 1A	48					cell cycle arrest|cellular response to extracellular stimulus|cellular response to ionizing radiation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|G2/M transition of mitotic cell cycle|induction of apoptosis by intracellular signals|negative regulation of cell growth|negative regulation of cell proliferation|positive regulation of fibroblast proliferation|positive regulation of reactive oxygen species metabolic process|Ras protein signal transduction|S phase of mitotic cell cycle|stress-induced premature senescence	cyclin-dependent protein kinase holoenzyme complex|cytosol|nucleoplasm|PCNA-p21 complex	cyclin-dependent protein kinase activating kinase activity|cyclin-dependent protein kinase inhibitor activity|metal ion binding			ovary(1)|breast(1)	2						GGCCCGTGAGCGATGGAACTT	0.662		NaN							Multiple_Endocrine_Neoplasia_type_1				0	0	0	0.012213	0	29	58									
AMPH	273	broad.mit.edu	37	7	38500927	38500927	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr7:38500927C>T	uc003tgu.2	-	11	1042	c.973G>A	c.(973-975)GAG>AAG	p.E325K	AMPH_uc003tgv.2_Missense_Mutation_p.E325K|AMPH_uc003tgt.2_Missense_Mutation_p.E78K	NM_001635	NP_001626	P49418	AMPH_HUMAN	amphiphysin isoform 1	325					endocytosis|synaptic transmission	actin cytoskeleton|cell junction|synaptic vesicle membrane				ovary(3)|liver(1)|skin(1)	5						AAGTTGTCCTCAAAGAAACTG	0.488		NaN											0	0	0	0.01441	0	54	79									
ZNF735	730291	broad.mit.edu	37	7	63680313	63680313	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr7:63680313G>A	uc011kdn.1	+	4	884	c.884G>A	c.(883-885)AGA>AAA	p.R295K		NM_001159524	NP_001152996	P0CB33	ZN735_HUMAN	zinc finger protein 735	295					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						ACTGGAGAGAGACCCTACAAA	0.448		NaN											0	0	0	0.004672	0	3	77									
OR2A12	346525	broad.mit.edu	37	7	143793013	143793013	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr7:143793013G>C	uc011kty.1	+	1	813	c.813G>C	c.(811-813)AAG>AAC	p.K271N		NM_001004135	NP_001004135	Q8NGT7	O2A12_HUMAN	olfactory receptor, family 2, subfamily A,	271	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|central_nervous_system(1)	3	Melanoma(164;0.0783)					AACGGAGGAAGATCCTTTCCC	0.522		NaN											0	0	0	0.001984	0	6	262									
EZH2	2146	broad.mit.edu	37	7	148511213	148511213	+	Silent	SNP	C	C	A	rs144723981		TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr7:148511213C>A	uc003wfd.1	-	15	1840	c.1674G>T	c.(1672-1674)CCG>CCT	p.P558P	EZH2_uc011kug.1_Silent_p.P507P|EZH2_uc003wfb.1_Silent_p.P563P|EZH2_uc003wfc.1_Silent_p.P519P|EZH2_uc011kuh.1_Silent_p.P549P	NM_004456	NP_004447	Q15910	EZH2_HUMAN	enhancer of zeste 2 isoform a	558	Cys-rich.				negative regulation of retinoic acid receptor signaling pathway|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	ESC/E(Z) complex	DNA binding|histone-lysine N-methyltransferase activity|protein binding			haematopoietic_and_lymphoid_tissue(180)|skin(2)|large_intestine(1)	183	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00239)			AGCGGCATCCCGGAAAGCGGT	0.473		NaN	Mis		DLBCL								1	0	2.43516e-34	0.01441	3.60404e-34	65	103									
MYOM2	9172	broad.mit.edu	37	8	2040194	2040194	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr8:2040194C>T	uc003wpx.3	+	16	1987	c.1849C>T	c.(1849-1851)CGG>TGG	p.R617W	MYOM2_uc011kwi.1_Missense_Mutation_p.R42W	NM_003970	NP_003961	P54296	MYOM2_HUMAN	myomesin 2	617	Fibronectin type-III 3.				muscle contraction	myosin filament	structural constituent of muscle			ovary(4)|central_nervous_system(1)|skin(1)	6		Ovarian(12;0.0572)|Colorectal(14;0.0844)|Hepatocellular(245;0.217)		BRCA - Breast invasive adenocarcinoma(11;1.85e-05)|Colorectal(4;0.0101)|READ - Rectum adenocarcinoma(4;0.148)|COAD - Colon adenocarcinoma(4;0.179)		TGCTCCGGGTCGGGTTCTTGC	0.547		NaN											0	0	0	0.01441	0	98	131									
RP1	6101	broad.mit.edu	37	8	55542115	55542115	+	Missense_Mutation	SNP	G	G	T	rs139088785	byFrequency	TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr8:55542115G>T	uc003xsd.1	+	4	5821	c.5673G>T	c.(5671-5673)TTG>TTT	p.L1891F	RP1_uc011ldy.1_Intron	NM_006269	NP_006260	P56715	RP1_HUMAN	retinitis pigmentosa RP1 protein	1891					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			skin(7)|ovary(4)|pancreas(1)	12		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			ACCAACCATTGCCTGGCAGTA	0.388		NaN											1	0	3.90053e-15	0.012213	4.73179e-15	30	50									
PRDM14	63978	broad.mit.edu	37	8	70970924	70970924	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr8:70970924C>T	uc003xym.2	-	6	1539	c.1337G>A	c.(1336-1338)CGG>CAG	p.R446Q		NM_024504	NP_078780	Q9GZV8	PRD14_HUMAN	PR domain containing 14	446	C2H2-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)	3	Breast(64;0.193)		Epithelial(68;0.00508)|all cancers(69;0.0259)|OV - Ovarian serous cystadenocarcinoma(28;0.0405)			GATCCGAAGCCGGTCCCGCTT	0.507		NaN											0	0	0	0.015359	0	29	42									
FAM91A1	157769	broad.mit.edu	37	8	124787454	124787454	+	Silent	SNP	C	C	T			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr8:124787454C>T	uc003yqv.2	+	3	286	c.225C>T	c.(223-225)CTC>CTT	p.L75L	FAM91A1_uc011lik.1_Silent_p.L75L|FAM91A1_uc011lil.1_5'UTR	NM_144963	NP_659400	Q658Y4	F91A1_HUMAN	hypothetical protein LOC157769	75										ovary(1)|central_nervous_system(1)	2	Lung NSC(37;8.76e-13)|Ovarian(258;0.00744)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00192)			GAGATCATCTCATGCTGTACC	0.388		NaN											0	0	0	0.005524	0	35	39									
MPDZ	8777	broad.mit.edu	37	9	13121876	13121876	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr9:13121876C>G	uc010mia.1	-	37	5150	c.5093G>C	c.(5092-5094)AGA>ACA	p.R1698T	MPDZ_uc003zkx.3_5'Flank|MPDZ_uc003zky.3_Missense_Mutation_p.R232T|MPDZ_uc010mib.2_Missense_Mutation_p.R403T|MPDZ_uc010mhx.2_Missense_Mutation_p.R520T|MPDZ_uc011lmm.1_Missense_Mutation_p.R557T|MPDZ_uc003zkz.3_Missense_Mutation_p.R391T|MPDZ_uc010mhy.2_Missense_Mutation_p.R1698T|MPDZ_uc010mhz.2_Missense_Mutation_p.R1665T|MPDZ_uc011lmn.1_Missense_Mutation_p.R1665T|MPDZ_uc003zlb.3_Missense_Mutation_p.R1698T	NM_003829	NP_003820	O75970	MPDZ_HUMAN	multiple PDZ domain protein	1698	PDZ 10.				interspecies interaction between organisms	apical plasma membrane|dendrite|postsynaptic density|postsynaptic membrane|synaptosome|tight junction	protein C-terminus binding			ovary(5)|central_nervous_system(1)	6				GBM - Glioblastoma multiforme(50;2.03e-06)		TGGCGTCTGTCTCAGGACATT	0.473		NaN											0	0	0	0.010729	0	11	2									
NTRK2	4915	broad.mit.edu	37	9	87366903	87366903	+	Silent	SNP	C	C	A			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr9:87366903C>A	uc004aoa.1	+	14	2237	c.1299C>A	c.(1297-1299)GTC>GTA	p.V433V	NTRK2_uc004anv.1_Silent_p.V420V|NTRK2_uc004any.1_Silent_p.V433V|NTRK2_uc004anz.1_Silent_p.V433V|NTRK2_uc011lsz.1_Silent_p.V433V|NTRK2_uc011lta.1_Silent_p.V433V|NTRK2_uc004aob.1_Silent_p.V433V|NTRK2_uc011ltb.1_Silent_p.V277V|NTRK2_uc004aoc.2_5'UTR	NM_001018064	NP_001018074	Q16620	NTRK2_HUMAN	neurotrophic tyrosine kinase, receptor, type 2	433	Helical; (Potential).				activation of adenylate cyclase activity|cell differentiation|nerve growth factor receptor signaling pathway|nervous system development	integral to plasma membrane	ATP binding|neurotrophin receptor activity|transmembrane receptor protein tyrosine kinase activity			lung(11)|central_nervous_system(1)|breast(1)|skin(1)|ovary(1)|liver(1)	16						TTCTCTAGGTCTATGCTGTGG	0.368		NaN								TSP Lung(25;0.17)			1	0	8.73648e-17	0.019004	1.09576e-16	29	35									
PTCH1	5727	broad.mit.edu	37	9	98209683	98209683	+	Missense_Mutation	SNP	C	C	A			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr9:98209683C>A	uc004avk.3	-	23	4043	c.3855G>T	c.(3853-3855)CAG>CAT	p.Q1285H	PTCH1_uc010mrn.2_Missense_Mutation_p.Q77H|PTCH1_uc010mro.2_Missense_Mutation_p.Q1134H|PTCH1_uc010mrp.2_Missense_Mutation_p.Q1134H|PTCH1_uc010mrq.2_Missense_Mutation_p.Q1134H|PTCH1_uc004avl.3_Missense_Mutation_p.Q1134H|PTCH1_uc010mrr.2_Missense_Mutation_p.Q1219H|PTCH1_uc004avm.3_Missense_Mutation_p.Q1284H	NM_000264	NP_000255	Q13635	PTC1_HUMAN	patched isoform L	1285	Cytoplasmic (Potential).				embryonic limb morphogenesis|negative regulation of multicellular organism growth|protein processing|regulation of smoothened signaling pathway|smoothened signaling pathway	integral to plasma membrane	hedgehog receptor activity			skin(242)|central_nervous_system(72)|bone(33)|upper_aerodigestive_tract(11)|lung(6)|large_intestine(4)|breast(4)|oesophagus(3)|ovary(3)|vulva(1)	379		Medulloblastoma(1;7.87e-06)|all_neural(1;0.000555)|Acute lymphoblastic leukemia(62;0.136)				CCAGGTGGGGCTGCTGTCTCG	0.677		NaN							Basal_Cell_Nevus_syndrome				1	0	1.49228e-48	0.01441	2.32482e-48	76	85									
OR1Q1	158131	broad.mit.edu	37	9	125377931	125377931	+	Missense_Mutation	SNP	G	G	A	rs112809062		TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr9:125377931G>A	uc011lyy.1	+	1	915	c.915G>A	c.(913-915)ATG>ATA	p.M305I		NM_012364	NP_036496	Q15612	OR1Q1_HUMAN	olfactory receptor, family 1, subfamily Q,	305	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						TGAAATGGATGAGCAGAATGC	0.443		NaN											0	0	0	0.021022	0	32	24									
ZBTB43	23099	broad.mit.edu	37	9	129595162	129595162	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr9:129595162G>A	uc004bql.2	+	3	647	c.374G>A	c.(373-375)GGA>GAA	p.G125E	ZBTB43_uc010mxf.2_Missense_Mutation_p.G125E	NM_014007	NP_054726	O43298	ZBT43_HUMAN	zinc finger and BTB domain containing 43	125					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						GTTTTAGAGGGAAACCCTACA	0.483		NaN											0	0	0	0.00499	0	15	24									
GUCY2F	2986	broad.mit.edu	37	X	108708376	108708376	+	Missense_Mutation	SNP	C	C	A	rs149453194	byFrequency	TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chrX:108708376C>A	uc004eod.3	-	3	1303	c.1027G>T	c.(1027-1029)GAT>TAT	p.D343Y	GUCY2F_uc011msq.1_RNA	NM_001522	NP_001513	P51841	GUC2F_HUMAN	guanylate cyclase 2F precursor	343	Extracellular (Potential).				intracellular signal transduction|receptor guanylyl cyclase signaling pathway|visual perception	integral to plasma membrane|nuclear outer membrane	ATP binding|GTP binding|guanylate cyclase activity|protein kinase activity|receptor activity			lung(4)|breast(3)|central_nervous_system(1)	8						CTTACTTGATCGAACTCCAGC	0.433		NaN											1	0	8.40228e-50	0.01441	1.33714e-49	61	7									
AFF2	2334	broad.mit.edu	37	X	148055007	148055007	+	Missense_Mutation	SNP	A	A	C			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chrX:148055007A>C	uc004fcp.2	+	16	3753	c.3274A>C	c.(3274-3276)AAA>CAA	p.K1092Q	AFF2_uc004fcq.2_Missense_Mutation_p.K1082Q|AFF2_uc004fcr.2_Missense_Mutation_p.K1053Q|AFF2_uc011mxb.1_Missense_Mutation_p.K1057Q|AFF2_uc004fcs.2_Missense_Mutation_p.K1057Q|AFF2_uc011mxc.1_Missense_Mutation_p.K733Q	NM_002025	NP_002016	P51816	AFF2_HUMAN	fragile X mental retardation 2	1092					brain development|mRNA processing|regulation of RNA splicing|RNA splicing	nuclear speck	G-quadruplex RNA binding|protein binding			ovary(3)|pancreas(2)	5	Acute lymphoblastic leukemia(192;6.56e-05)					TCAGTTCGAGAAATTTGGCAA	0.373		NaN											0	0	0	0.01441	0	76	6									
MLL2	8085	broad.mit.edu	37	12	49420342	49420343	+	Frame_Shift_Ins	INS	-	-	GC			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08			-	GC	-	-		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr12:49420342_49420343insGC	uc001rta.3	-	48	15406_15407	c.15406_15407insGC	c.(15406-15408)CATfs	p.H5136fs		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	5136	RING-type 4; degenerate.				chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						CTTGATCTTATGCATTGGACAC	0.52		NaN	N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			NaN	NaN	NaN	NaN	NaN	53	76	---	---							
KRT84	3890	broad.mit.edu	37	12	52771821	52771822	+	Frame_Shift_Ins	INS	-	-	TA			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr12:52771821_52771822insTA	uc001sah.1	-	9	1847_1848	c.1799_1800insTA	c.(1798-1800)TACfs	p.Y600fs		NM_033045	NP_149034	Q9NSB2	KRT84_HUMAN	keratin, hair, basic, 4	600	Tail.					keratin filament	structural constituent of epidermis			skin(1)	1	all_hematologic(5;0.12)			BRCA - Breast invasive adenocarcinoma(357;0.189)		TGGGCTCTCAGTACTTGGTCCG	0.688		NaN											NaN	NaN	NaN	NaN	NaN	4	7	---	---							
HDC	3067	broad.mit.edu	37	15	50557790	50557791	+	Frame_Shift_Del	DEL	CT	CT	-			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr15:50557790_50557791delCT	uc001zxz.2	-	1	136_137	c.30_31delAG	c.(28-33)AGAGGGfs	p.R10fs	HDC_uc010uff.1_Frame_Shift_Del_p.R10fs|HDC_uc010bet.1_Frame_Shift_Del_p.R10fs|HDC_uc010beu.1_Frame_Shift_Del_p.R10fs	NM_002112	NP_002103	P19113	DCHS_HUMAN	histidine decarboxylase	10_11					catecholamine biosynthetic process|histidine metabolic process		histidine decarboxylase activity			large_intestine(2)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	6		all_lung(180;0.0138)		all cancers(107;1.12e-06)|GBM - Glioblastoma multiforme(94;9.95e-05)	L-Histidine(DB00117)|Pyridoxal Phosphate(DB00114)	CGTTGCTCACCTCTCTCTCTGT	0.599		NaN											NaN	NaN	NaN	NaN	NaN	8	80	---	---							
ZNF598	90850	broad.mit.edu	37	16	2049881	2049883	+	In_Frame_Del	DEL	CGT	CGT	-	rs141374045	by1000genomes	TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr16:2049881_2049883delCGT	uc002cof.1	-	11	1682_1684	c.1667_1669delACG	c.(1666-1671)GACGGC>GGC	p.D556del	ZNF598_uc002coe.1_5'UTR	NM_178167	NP_835461	Q86UK7	ZN598_HUMAN	zinc finger protein 598	556						intracellular	zinc ion binding			lung(1)|breast(1)	2						GCCGGGCCGCCGTCCTCCTCCTC	0.7		NaN											NaN	NaN	NaN	NaN	NaN	2	4	---	---							
GRIN2C	2905	broad.mit.edu	37	17	72839417	72839418	+	Frame_Shift_Ins	INS	-	-	G			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr17:72839417_72839418insG	uc002jlt.1	-	13	3014_3015	c.2858_2859insC	c.(2857-2859)CCAfs	p.P953fs	GRIN2C_uc010wrh.1_RNA	NM_000835	NP_000826	Q14957	NMDE3_HUMAN	N-methyl-D-aspartate receptor subunit 2C	953	Cytoplasmic (Potential).				glutamate signaling pathway	cell junction|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|N-methyl-D-aspartate selective glutamate receptor activity			ovary(2)|breast(2)	4	all_lung(278;0.172)|Lung NSC(278;0.207)				Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)	GGCTCGGCTCTGGGGGCGGGTC	0.663		NaN											NaN	NaN	NaN	NaN	NaN	2	4	---	---							
OGDH	4967	broad.mit.edu	37	7	44684936	44684936	+	Frame_Shift_Del	DEL	T	T	-			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr7:44684936delT	uc003tln.2	+	3	342	c.233delT	c.(232-234)ATTfs	p.I78fs	OGDH_uc003tlm.2_Frame_Shift_Del_p.I78fs|OGDH_uc011kbx.1_Frame_Shift_Del_p.I78fs|OGDH_uc011kby.1_Intron|OGDH_uc003tlp.2_Frame_Shift_Del_p.I78fs|OGDH_uc011kbz.1_5'UTR|OGDH_uc003tlo.1_5'UTR	NM_002541	NP_002532	Q02218	ODO1_HUMAN	oxoglutarate dehydrogenase isoform 1 precursor	78					glycolysis|lysine catabolic process|tricarboxylic acid cycle	mitochondrial matrix|mitochondrial membrane	oxoglutarate dehydrogenase (succinyl-transferring) activity|thiamine pyrophosphate binding			upper_aerodigestive_tract(1)|ovary(1)	2					NADH(DB00157)	TCATGGGACATTTTTTTTCGC	0.577		NaN											NaN	NaN	NaN	NaN	NaN	7	246	---	---							
RBM33	155435	broad.mit.edu	37	7	155531073	155531074	+	Frame_Shift_Del	DEL	CA	CA	-			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr7:155531073_155531074delCA	uc010lqk.1	+	11	2081_2082	c.1713_1714delCA	c.(1711-1716)CCCACAfs	p.P571fs	RBM33_uc011kvv.1_Frame_Shift_Del_p.P380fs	NM_053043	NP_444271	Q96EV2	RBM33_HUMAN	RNA binding motif protein 33	571_572	Pro-rich.						nucleotide binding|RNA binding			ovary(1)	1	all_neural(206;0.101)	all_hematologic(28;0.0592)	OV - Ovarian serous cystadenocarcinoma(82;0.011)	UCEC - Uterine corpus endometrioid carcinoma (81;0.2)		CGTTTCTGCCCACACACACACA	0.53		NaN											NaN	NaN	NaN	NaN	NaN	7	113	---	---							
PCM1	5108	broad.mit.edu	37	8	17868136	17868137	+	Frame_Shift_Ins	INS	-	-	TC			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr8:17868136_17868137insTC	uc003wyi.3	+	32	5601_5602	c.5179_5180insTC	c.(5179-5181)GATfs	p.D1727fs	PCM1_uc011kyh.1_Frame_Shift_Ins_p.D1719fs|PCM1_uc003wyj.3_Frame_Shift_Ins_p.D1673fs|PCM1_uc011kyi.1_Frame_Shift_Ins_p.D526fs|PCM1_uc011kyj.1_Frame_Shift_Ins_p.D483fs|PCM1_uc003wyk.3_Frame_Shift_Ins_p.D409fs|PCM1_uc011kyk.1_Frame_Shift_Ins_p.D343fs	NM_006197	NP_006188	Q15154	PCM1_HUMAN	pericentriolar material 1	1727	Interaction with HAP1.				centrosome organization|cilium assembly|G2/M transition of mitotic cell cycle|interkinetic nuclear migration|microtubule anchoring|negative regulation of neurogenesis|protein localization to centrosome	centriolar satellite|cytosol|nuclear membrane|pericentriolar material	identical protein binding		PCM1/JAK2(30)	haematopoietic_and_lymphoid_tissue(30)|breast(4)|ovary(2)	36				Colorectal(111;0.0789)		GATTCTTGAAGATCATGGCTCA	0.218		NaN	T	RET|JAK2	papillary thyroid|CML|MPD								NaN	NaN	NaN	NaN	NaN	12	15	---	---