Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	isArtifactMode	oxoGCut	pox	pox_cutoff	qox	t_alt_count	t_ref_count	validation_alt_allele	validation_tumor_sample							
CLCNKB	1188	broad.mit.edu	37	1	16375654	16375654	+	Missense_Mutation	SNP	C	C	G			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr1:16375654C>G	uc001axw.3	+	8	775	c.695C>G	c.(694-696)TCT>TGT	p.S232C	FAM131C_uc010obz.1_Intron|CLCNKB_uc001axx.3_Missense_Mutation_p.S232C|CLCNKB_uc001axy.3_Missense_Mutation_p.S63C	NM_000085	NP_000076	P51801	CLCKB_HUMAN	chloride channel Kb isoform 1	232					excretion	chloride channel complex|integral to plasma membrane	voltage-gated chloride channel activity			skin(1)	1		Colorectal(325;3.46e-05)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Colorectal(212;8.04e-08)|COAD - Colon adenocarcinoma(227;5.46e-06)|BRCA - Breast invasive adenocarcinoma(304;9.02e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(313;0.00655)|READ - Rectum adenocarcinoma(331;0.0649)		TCCCACTTCTCTGTCTGGGAT	0.637		NaN											0	0	0	0.134883	0	27	66									
ALDH4A1	8659	broad.mit.edu	37	1	19204070	19204070	+	Missense_Mutation	SNP	G	G	A	rs139430775		TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr1:19204070G>A	uc001bbb.2	-	10	1253	c.977C>T	c.(976-978)TCG>TTG	p.S326L	ALDH4A1_uc010ocu.1_Missense_Mutation_p.S266L|ALDH4A1_uc001bbc.2_Missense_Mutation_p.S326L	NM_170726	NP_733844	P30038	AL4A1_HUMAN	aldehyde dehydrogenase 4A1 isoform a precursor	326					proline biosynthetic process|proline catabolic process	mitochondrial matrix	1-pyrroline-5-carboxylate dehydrogenase activity|aldehyde dehydrogenase (NAD) activity|electron carrier activity				0		Colorectal(325;3.46e-05)|all_lung(284;0.000321)|Lung NSC(340;0.000398)|Renal(390;0.000518)|Breast(348;0.000812)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00479)|BRCA - Breast invasive adenocarcinoma(304;3.67e-05)|Kidney(64;0.000182)|KIRC - Kidney renal clear cell carcinoma(64;0.00269)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)	NADH(DB00157)	CACGTCGGCCGAGCGGTGCAC	0.672		NaN											0	0	0	0.009096	0	3	19									
GRHL3	57822	broad.mit.edu	37	1	24664503	24664503	+	Missense_Mutation	SNP	G	G	A	rs141594535		TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr1:24664503G>A	uc001biy.2	+	7	923	c.877G>A	c.(877-879)GAC>AAC	p.D293N	GRHL3_uc001bix.2_Missense_Mutation_p.D288N|GRHL3_uc001biz.2_Missense_Mutation_p.D195N	NM_021180	NP_067003	Q8TE85	GRHL3_HUMAN	sister-of-mammalian grainyhead protein isoform	288					regulation of actin cytoskeleton organization|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(1)	1		Colorectal(325;3.46e-05)|Renal(390;0.0007)|Lung NSC(340;0.00171)|all_lung(284;0.00226)|Ovarian(437;0.00348)|Breast(348;0.0126)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.19)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;8.72e-25)|Colorectal(126;4.38e-08)|COAD - Colon adenocarcinoma(152;1.84e-06)|GBM - Glioblastoma multiforme(114;0.000132)|BRCA - Breast invasive adenocarcinoma(304;0.00105)|STAD - Stomach adenocarcinoma(196;0.00151)|KIRC - Kidney renal clear cell carcinoma(1967;0.00377)|READ - Rectum adenocarcinoma(331;0.0656)|Lung(427;0.143)		GGTTGTCTTCGACAATGAGAA	0.572		NaN											0	0	0	0.117977	0	35	69									
GPN2	54707	broad.mit.edu	37	1	27216470	27216470	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr1:27216470C>T	uc001bnd.1	-	1	400	c.118G>A	c.(118-120)GTG>ATG	p.V40M		NM_018066	NP_060536	Q9H9Y4	GPN2_HUMAN	ATP binding domain 1 family, member B	40							GTP binding				0						ACCACCGCCACGCGCCGGCCC	0.721		NaN											0	0	0	0.009096	0	3	12									
CSMD2	114784	broad.mit.edu	37	1	34208906	34208906	+	Silent	SNP	C	C	T			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr1:34208906C>T	uc001bxn.1	-	14	2057	c.2028G>A	c.(2026-2028)AAG>AAA	p.K676K	CSMD2_uc001bxm.1_Silent_p.K716K	NM_052896	NP_443128	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	676	Extracellular (Potential).|CUB 4.					integral to membrane|plasma membrane	protein binding			ovary(6)|skin(5)|pancreas(1)	12		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				TGAAGCCCCTCTTCCCTGTGG	0.582		NaN											0	0	0	0.02938	0	5	20									
MTF1	4520	broad.mit.edu	37	1	38289456	38289456	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr1:38289456G>A	uc001cce.1	-	8	1238	c.1097C>T	c.(1096-1098)TCA>TTA	p.S366L	MTF1_uc009vvj.1_Missense_Mutation_p.S57L	NM_005955	NP_005946	Q14872	MTF1_HUMAN	metal-regulatory transcription factor 1	366						nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|zinc ion binding			ovary(1)|pancreas(1)	2	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0255)				GATTGCTGGTGAAATTGTGCT	0.438		NaN											0	0	0	0.069288	0	18	34									
RHBDL2	54933	broad.mit.edu	37	1	39384795	39384795	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr1:39384795C>T	uc001ccu.1	-	2	318	c.90G>A	c.(88-90)ATG>ATA	p.M30I	RHBDL2_uc010oin.1_Missense_Mutation_p.M30I|RHBDL2_uc010oio.1_Missense_Mutation_p.M110I|RHBDL2_uc001ccv.2_Missense_Mutation_p.M30I	NM_017821	NP_060291	Q9NX52	RHBL2_HUMAN	rhomboid protease 2	30					proteolysis	integral to membrane|plasma membrane	serine-type endopeptidase activity				0	Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;8.23e-17)			CATCCTCTCTCATTTTCTCCT	0.488		NaN											0	0	0	0.134883	0	27	91									
CYP4A22	284541	broad.mit.edu	37	1	47603168	47603168	+	Missense_Mutation	SNP	C	C	G			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr1:47603168C>G	uc001cqv.1	+	1	62	c.11C>G	c.(10-12)TCT>TGT	p.S4C	CYP4A22_uc009vyo.2_Missense_Mutation_p.S4C|CYP4A22_uc009vyp.2_Missense_Mutation_p.S4C	NM_001010969	NP_001010969	Q5TCH4	CP4AM_HUMAN	cytochrome P450, family 4, subfamily A,	4						endoplasmic reticulum membrane|microsome	alkane 1-monooxygenase activity|electron carrier activity|heme binding			skin(2)|ovary(1)|breast(1)	4						ATGAGTGTCTCTGTCCTGAGC	0.597		NaN											0	0	0	0.125774	0	28	70									
LRRC7	57554	broad.mit.edu	37	1	70504238	70504238	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr1:70504238G>A	uc001dep.2	+	19	2647	c.2617G>A	c.(2617-2619)GAA>AAA	p.E873K	LRRC7_uc009wbg.2_Missense_Mutation_p.E157K|LRRC7_uc001deq.2_Missense_Mutation_p.E114K	NM_020794	NP_065845	Q96NW7	LRRC7_HUMAN	leucine rich repeat containing 7	873						centrosome|focal adhesion|nucleolus	protein binding			ovary(9)|breast(2)|central_nervous_system(2)|liver(1)	14						CCCATTGCCTGAAAGGAAAGA	0.458		NaN											0	0	0	0.139131	0	35	63									
CCDC18	343099	broad.mit.edu	37	1	93680450	93680450	+	Missense_Mutation	SNP	G	G	C			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr1:93680450G>C	uc001dpq.2	+	12	2168	c.2000G>C	c.(1999-2001)AGA>ACA	p.R667T	CCDC18_uc009wdl.1_Missense_Mutation_p.R228T	NM_206886	NP_996769	Q5T9S5	CCD18_HUMAN	sarcoma antigen NY-SAR-41	548	Potential.									ovary(2)|breast(2)|pancreas(1)	5		all_lung(203;0.00196)|Lung NSC(277;0.00903)|Melanoma(281;0.099)|all_neural(321;0.185)|Glioma(108;0.203)		all cancers(265;0.00166)|GBM - Glioblastoma multiforme(16;0.00551)|Epithelial(280;0.0967)		ATGGCTCACAGAACTAGTCAG	0.383		NaN											0	0	0	0.058154	0	8	14									
PDE4DIP	9659	broad.mit.edu	37	1	144879256	144879256	+	Silent	SNP	C	C	A			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr1:144879256C>A	uc001elw.3	-	27	4485	c.4194G>T	c.(4192-4194)CTG>CTT	p.L1398L	NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|PDE4DIP_uc001elk.1_Intron|PDE4DIP_uc001ell.1_Intron|PDE4DIP_uc001elm.3_Intron|PDE4DIP_uc001eln.3_Intron|PDE4DIP_uc001elo.2_Intron|PDE4DIP_uc001elx.3_Silent_p.L1354L|PDE4DIP_uc001elv.3_Silent_p.L405L	NM_014644	NP_055459	Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein isoform	1398					cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			ovary(4)|haematopoietic_and_lymphoid_tissue(1)	5				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		CAACAGCTCTCAGCTTCCAGG	0.537		NaN	T	PDGFRB	MPD								1	0	1.00905e-13	0.049695	1.09023e-13	19	102									
PDE4DIP	9659	broad.mit.edu	37	1	144882724	144882724	+	Nonsense_Mutation	SNP	G	G	A			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr1:144882724G>A	uc001elw.3	-	24	3586	c.3295C>T	c.(3295-3297)CAG>TAG	p.Q1099*	NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|PDE4DIP_uc001elk.1_Intron|PDE4DIP_uc001ell.1_Intron|PDE4DIP_uc001elm.3_Intron|PDE4DIP_uc001eln.3_Intron|PDE4DIP_uc001elo.2_Intron|PDE4DIP_uc001elx.3_Intron|PDE4DIP_uc001elv.3_Nonsense_Mutation_p.Q106*	NM_014644	NP_055459	Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein isoform	1099	Potential.				cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			ovary(4)|haematopoietic_and_lymphoid_tissue(1)	5				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		AACTCAGCCTGAAGGCTACTC	0.483		NaN	T	PDGFRB	MPD								0	0	0	0.139131	0	38	208									
RPRD2	23248	broad.mit.edu	37	1	150444774	150444774	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr1:150444774G>A	uc009wlr.2	+	11	3551	c.3350G>A	c.(3349-3351)AGA>AAA	p.R1117K	RPRD2_uc010pcc.1_3'UTR|RPRD2_uc001eup.3_Missense_Mutation_p.R1091K	NM_015203	NP_056018	Q5VT52	RPRD2_HUMAN	Regulation of nuclear pre-mRNA domain containing	1117							protein binding			ovary(1)	1						AAGGGAAATAGAGGACATGGG	0.522		NaN											0	0	0	0.038147	0	6	19									
HORMAD1	84072	broad.mit.edu	37	1	150679139	150679139	+	Nonsense_Mutation	SNP	G	G	A	rs150156011		TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr1:150679139G>A	uc001evk.1	-	10	800	c.694C>T	c.(694-696)CGA>TGA	p.R232*	HORMAD1_uc001evl.1_Nonsense_Mutation_p.R225*|HORMAD1_uc001evm.1_Nonsense_Mutation_p.R152*	NM_032132	NP_115508	Q86X24	HORM1_HUMAN	HORMA domain containing 1	232					blastocyst development|cell differentiation|meiotic DNA double-strand break formation|meiotic recombination checkpoint|meiotic sister chromatid cohesion|mitosis|oogenesis|regulation of homologous chromosome segregation|spermatogenesis|synaptonemal complex assembly	chromosome|nucleus				ovary(2)|central_nervous_system(1)	3	all_cancers(9;3.23e-52)|all_epithelial(9;4.68e-43)|all_lung(15;5.74e-35)|Lung NSC(24;2.09e-31)|Breast(34;0.0009)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Melanoma(130;0.128)|Colorectal(459;0.171)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0241)|Epithelial(6;2.32e-23)|all cancers(9;5.21e-23)|OV - Ovarian serous cystadenocarcinoma(6;6.72e-15)|BRCA - Breast invasive adenocarcinoma(12;0.000479)|LUSC - Lung squamous cell carcinoma(543;0.171)			TTTTCCATTCGTTCTCTCTCA	0.353		NaN											0	0	0	0.076483	0	18	64									
CELF3	11189	broad.mit.edu	37	1	151678328	151678328	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr1:151678328C>T	uc001eys.1	-	11	2034	c.1240G>A	c.(1240-1242)GAC>AAC	p.D414N	CELF3_uc010pdh.1_Missense_Mutation_p.D200N|CELF3_uc001eyr.2_Missense_Mutation_p.D413N|CELF3_uc009wmy.2_Missense_Mutation_p.D364N|CELF3_uc009wmx.1_Missense_Mutation_p.D413N	NM_007185	NP_009116	Q5SZQ8	CELF3_HUMAN	trinucleotide repeat containing 4	414	RRM 3.				nuclear mRNA splicing, via spliceosome|regulation of alternative nuclear mRNA splicing, via spliceosome	cytoplasm|nucleus	mRNA binding|nucleotide binding			ovary(1)|central_nervous_system(1)	2						GTGGCTCGGTCAACAAAGACT	0.438		NaN											0	0	0	0.132662	0	13	30									
TCHH	7062	broad.mit.edu	37	1	152080269	152080269	+	Silent	SNP	T	T	C			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr1:152080269T>C	uc001ezp.2	-	2	5424	c.5424A>G	c.(5422-5424)GAA>GAG	p.E1808E	TCHH_uc009wne.1_Silent_p.E1808E	NM_007113	NP_009044	Q07283	TRHY_HUMAN	trichohyalin	1808	23 X 26 AA approximate tandem repeats.				keratinization	cytoskeleton	calcium ion binding			ovary(3)|kidney(1)|central_nervous_system(1)	5	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GCTGCTGTTCTTCCCTCTCCT	0.597		NaN											0	0	0	0.009096	0	3	72									
IL6R	3570	broad.mit.edu	37	1	154420627	154420627	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr1:154420627G>A	uc001fez.1	+	7	1413	c.976G>A	c.(976-978)GAG>AAG	p.E326K	IL6R_uc001ffa.1_Missense_Mutation_p.E326K	NM_000565	NP_000556	P08887	IL6RA_HUMAN	interleukin 6 receptor isoform 1 precursor	326	Extracellular (Potential).				acute-phase response|ciliary neurotrophic factor-mediated signaling pathway|defense response to Gram-negative bacterium|defense response to Gram-positive bacterium|endocrine pancreas development|hepatic immune response|negative regulation of collagen biosynthetic process|negative regulation of interleukin-8 production|positive regulation of activation of Janus kinase activity|positive regulation of anti-apoptosis|positive regulation of chemokine production|positive regulation of chemokine production|positive regulation of interleukin-6 production|positive regulation of leukocyte chemotaxis|positive regulation of MAPKKK cascade|positive regulation of osteoblast differentiation|positive regulation of smooth muscle cell proliferation|positive regulation of tyrosine phosphorylation of Stat3 protein|regulation of apoptosis	apical plasma membrane|basolateral plasma membrane|extracellular space|interleukin-6 receptor complex	ciliary neurotrophic factor binding|enzyme binding|protein homodimerization activity			ovary(3)|breast(1)	4	all_lung(78;1.72e-29)|Lung NSC(65;2.96e-27)|Hepatocellular(266;0.0877)		LUSC - Lung squamous cell carcinoma(543;0.185)			AGCTGAGAACGAGGTGTCCAC	0.463		NaN											0	0	0	0.139131	0	38	64									
RXRG	6258	broad.mit.edu	37	1	165398029	165398029	+	Missense_Mutation	SNP	G	G	T			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr1:165398029G>T	uc001gda.2	-	2	524	c.224C>A	c.(223-225)TCT>TAT	p.S75Y		NM_006917	NP_008848	P48443	RXRG_HUMAN	retinoid X receptor, gamma isoform a	75	Modulating (By similarity).				regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	retinoid-X receptor activity|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|zinc ion binding				0	all_hematologic(923;0.0773)|Acute lymphoblastic leukemia(8;0.155)				Acitretin(DB00459)|Adapalene(DB00210)|Alitretinoin(DB00523)|Etretinate(DB00926)|Tretinoin(DB00755)	GCCCATGGCAGAGGTGATGAC	0.602		NaN											1	0	4.63292e-17	0.049695	5.06389e-17	18	28									
C1orf116	79098	broad.mit.edu	37	1	207196604	207196604	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr1:207196604C>T	uc001hfd.2	-	4	764	c.505G>A	c.(505-507)GAG>AAG	p.E169K	C1orf116_uc009xcb.1_5'UTR	NM_023938	NP_076427	Q9BW04	SARG_HUMAN	specifically androgen-regulated protein isoform	169						cytoplasm|plasma membrane	receptor activity	p.E169E(1)		skin(2)|ovary(1)|central_nervous_system(1)	4	Prostate(682;0.19)					TGTTCTTTCTCAGGCTCTGGC	0.602		NaN											0	0	0	0.083992	0	25	33									
ARID4B	51742	broad.mit.edu	37	1	235331917	235331917	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr1:235331917C>T	uc001hwq.2	-	24	4360	c.3862G>A	c.(3862-3864)GCT>ACT	p.A1288T	ARID4B_uc001hwr.2_Missense_Mutation_p.A1202T|ARID4B_uc001hwp.2_RNA	NM_016374	NP_057458	Q4LE39	ARI4B_HUMAN	AT rich interactive domain 4B isoform 1	1288	Ser-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|protein binding			ovary(2)|lung(1)	3	Ovarian(103;0.0473)|Breast(184;0.23)	all_cancers(173;0.000782)|Prostate(94;0.0132)|all_epithelial(177;0.0808)|Lung SC(1967;0.24)	OV - Ovarian serous cystadenocarcinoma(106;2.86e-05)			ATAACAGCAGCTGTTATGGAA	0.428		NaN											0	0	0	0.146539	0	14	28									
ZNF695	57116	broad.mit.edu	37	1	247151490	247151490	+	Silent	SNP	C	C	T			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr1:247151490C>T	uc009xgu.2	-	4	472	c.327G>A	c.(325-327)GTG>GTA	p.V109V	ZNF695_uc001ica.2_RNA|ZNF695_uc001icb.1_RNA|ZNF695_uc009xgt.1_RNA|ZNF695_uc001ibx.2_Silent_p.V109V|ZNF695_uc001iby.2_Intron|ZNF695_uc001icc.2_Silent_p.V97V	NM_020394	NP_065127	Q8IW36	ZN695_HUMAN	zinc finger protein SBZF3	109					regulation of transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding				0	all_cancers(71;4.01e-05)|all_epithelial(71;6.72e-06)|Ovarian(71;0.0173)|Breast(184;0.0318)|all_lung(81;0.0458)|Lung NSC(105;0.0518)	all_cancers(173;0.0266)	OV - Ovarian serous cystadenocarcinoma(106;0.00271)			TTCTCAGCATCACTTTTTGGA	0.373		NaN											0	0	0	0.0918	0	27	54									
ANKRD30A	91074	broad.mit.edu	37	10	37430948	37430948	+	Missense_Mutation	SNP	C	C	G			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr10:37430948C>G	uc001iza.1	+	7	1054	c.955C>G	c.(955-957)CCA>GCA	p.P319A		NM_052997	NP_443723	Q9BXX3	AN30A_HUMAN	ankyrin repeat domain 30A	375						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(7)|breast(1)|skin(1)	9						ATTTACGTGGCCAGCAAAAGG	0.423		NaN											0	0	0	0.014758	0	3	75									
ANKRD30A	91074	broad.mit.edu	37	10	37431050	37431050	+	Missense_Mutation	SNP	G	G	C			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr10:37431050G>C	uc001iza.1	+	7	1156	c.1057G>C	c.(1057-1059)GCA>CCA	p.A353P		NM_052997	NP_443723	Q9BXX3	AN30A_HUMAN	ankyrin repeat domain 30A	409						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(7)|breast(1)|skin(1)	9						ATTTACGTGGGCAGCAAAAGG	0.408		NaN											0	0	0	0.021553	0	4	69									
GDF2	2658	broad.mit.edu	37	10	48414156	48414156	+	Missense_Mutation	SNP	C	C	T	rs137873272		TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr10:48414156C>T	uc001jfa.1	-	2	875	c.712G>A	c.(712-714)GAC>AAC	p.D238N		NM_016204	NP_057288	Q9UK05	GDF2_HUMAN	growth differentiation factor 2 precursor	238					activin receptor signaling pathway|BMP signaling pathway|cartilage development|cellular iron ion homeostasis|growth|negative regulation of angiogenesis|negative regulation of blood vessel endothelial cell migration|negative regulation of cell growth|negative regulation of DNA replication|negative regulation of endothelial cell proliferation|ossification|pathway-restricted SMAD protein phosphorylation|patterning of blood vessels|positive regulation of angiogenesis|positive regulation of endothelial cell proliferation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of transcription, DNA-dependent	extracellular space	cytokine activity|growth factor activity			ovary(2)|skin(1)	3						TCCAGCGTGTCGCAGCCCTTC	0.577		NaN											0	0	0	0.146539	0	14	21									
OGDHL	55753	broad.mit.edu	37	10	50952768	50952768	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr10:50952768C>T	uc001jie.2	-	13	1802	c.1660G>A	c.(1660-1662)GAG>AAG	p.E554K	OGDHL_uc009xog.2_Missense_Mutation_p.E581K|OGDHL_uc010qgt.1_Missense_Mutation_p.E497K|OGDHL_uc010qgu.1_Missense_Mutation_p.E345K|OGDHL_uc009xoh.2_Missense_Mutation_p.E345K	NM_018245	NP_060715	Q9ULD0	OGDHL_HUMAN	oxoglutarate dehydrogenase-like isoform a	554					glycolysis	mitochondrial matrix	oxoglutarate dehydrogenase (succinyl-transferring) activity|thiamine pyrophosphate binding			pancreas(1)	1						TAAGCCTCCTCACAGATCCGG	0.542		NaN											0	0	0	0.0918	0	21	40									
TET1	80312	broad.mit.edu	37	10	70446167	70446167	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr10:70446167G>A	uc001jok.3	+	11	5612	c.5107G>A	c.(5107-5109)GAG>AAG	p.E1703K		NM_030625	NP_085128	Q8NFU7	TET1_HUMAN	CXXC finger 6	1703					DNA demethylation|inner cell mass cell differentiation|negative regulation of methylation-dependent chromatin silencing|stem cell maintenance		iron ion binding|methylcytosine dioxygenase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|structure-specific DNA binding|zinc ion binding			ovary(5)|lung(2)|prostate(1)|breast(1)	9						TCCTCAAGATGAGCAGCTCCA	0.453		NaN											0	0	0	0.099896	0	22	53									
HKDC1	80201	broad.mit.edu	37	10	71008378	71008378	+	Silent	SNP	G	G	A			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr10:71008378G>A	uc001jpf.3	+	10	1597	c.1464G>A	c.(1462-1464)CAG>CAA	p.Q488Q	HKDC1_uc010qje.1_Silent_p.Q351Q	NM_025130	NP_079406	Q2TB90	HKDC1_HUMAN	hexokinase domain containing 1	488					glycolysis	mitochondrion|nucleus	ATP binding|hexokinase activity			ovary(4)|skin(1)	5						TGGACGTGCAGGCCAAGATGC	0.667		NaN											0	0	0	0.069234	0	9	15									
FGF8	2253	broad.mit.edu	37	10	103534601	103534601	+	Silent	SNP	G	G	C			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr10:103534601G>C	uc001ktp.1	-	4	362	c.192C>G	c.(190-192)CTC>CTG	p.L64L	FGF8_uc001ktq.1_Silent_p.L75L|FGF8_uc001ktr.1_Silent_p.L46L|FGF8_uc001kts.1_Silent_p.L35L|FGF8_uc009xwr.1_5'UTR	NM_033164	NP_149354	P55075	FGF8_HUMAN	fibroblast growth factor 8 isoform E precursor	64					bone development|dopaminergic neuron differentiation|fibroblast growth factor receptor signaling pathway|gastrulation|gonad development|insulin receptor signaling pathway|mesonephros development|metanephros development|negative regulation of cardiac muscle tissue development|neuroepithelial cell differentiation|odontogenesis|positive regulation of cell division|positive regulation of cell proliferation	extracellular region|extracellular space	growth factor activity|growth factor activity|type 1 fibroblast growth factor receptor binding|type 2 fibroblast growth factor receptor binding				0		Colorectal(252;0.122)		Epithelial(162;3.94e-09)|all cancers(201;2.13e-07)		GGCGGCGGCTGAGCTGATCCG	0.542		NaN											0	0	0	0.069234	0	10	19									
C10orf79	80217	broad.mit.edu	37	10	105903255	105903255	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr10:105903255C>T	uc001kxw.2	-	32	4203	c.4087G>A	c.(4087-4089)GAA>AAA	p.E1363K	C10orf79_uc009xxq.2_Missense_Mutation_p.E642K	NM_025145	NP_079421	Q8NDM7	WDR96_HUMAN	hypothetical protein LOC80217	1363											0		Colorectal(252;0.178)		Epithelial(162;4.83e-10)|all cancers(201;2.26e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0194)		TCCAAGCCTTCTGGCATGTTA	0.383		NaN											0	0	0	0.108266	0	22	53									
SORCS3	22986	broad.mit.edu	37	10	106960946	106960946	+	Silent	SNP	G	G	A			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr10:106960946G>A	uc001kyi.1	+	16	2423	c.2196G>A	c.(2194-2196)CTG>CTA	p.L732L	SORCS3_uc010qqz.1_RNA	NM_014978	NP_055793	Q9UPU3	SORC3_HUMAN	VPS10 domain receptor protein SORCS 3 precursor	732	Lumenal (Potential).					integral to membrane	neuropeptide receptor activity			ovary(6)|skin(3)|central_nervous_system(1)	10		Colorectal(252;0.134)|Breast(234;0.142)|Lung NSC(174;0.191)		Epithelial(162;1.58e-07)|all cancers(201;1.02e-05)|BRCA - Breast invasive adenocarcinoma(275;0.0628)		AGTGTGCCCTGGGCCGAGACC	0.488		NaN											0	0	0	0.0918	0	22	45									
SORCS1	114815	broad.mit.edu	37	10	108371675	108371675	+	Silent	SNP	C	C	T			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr10:108371675C>T	uc001kym.2	-	22	3035	c.3027G>A	c.(3025-3027)CTG>CTA	p.L1009L	SORCS1_uc001kyl.2_Silent_p.L1009L|SORCS1_uc009xxs.2_Silent_p.L1009L|SORCS1_uc001kyn.1_Silent_p.L1009L|SORCS1_uc001kyo.2_Silent_p.L1009L	NM_052918	NP_443150	Q8WY21	SORC1_HUMAN	SORCS receptor 1 isoform a	1009	Lumenal (Potential).					integral to membrane	neuropeptide receptor activity|protein binding			breast(1)|central_nervous_system(1)	2		Breast(234;0.0256)|Colorectal(252;0.09)|Lung NSC(174;0.168)		Epithelial(162;1.66e-05)|all cancers(201;0.000689)		TCACTTCCACCAGGGATTTTT	0.483		NaN											0	0	0	0.02938	0	6	23									
SORCS1	114815	broad.mit.edu	37	10	108923757	108923757	+	Silent	SNP	G	G	T			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr10:108923757G>T	uc001kym.2	-	1	536	c.528C>A	c.(526-528)GCC>GCA	p.A176A	SORCS1_uc001kyl.2_Silent_p.A176A|SORCS1_uc009xxs.2_Silent_p.A176A|SORCS1_uc001kyn.1_Silent_p.A176A|SORCS1_uc001kyo.2_Silent_p.A176A	NM_052918	NP_443150	Q8WY21	SORC1_HUMAN	SORCS receptor 1 isoform a	176	Lumenal (Potential).					integral to membrane	neuropeptide receptor activity|protein binding			breast(1)|central_nervous_system(1)	2		Breast(234;0.0256)|Colorectal(252;0.09)|Lung NSC(174;0.168)		Epithelial(162;1.66e-05)|all cancers(201;0.000689)		AGTGGACCATGGCTTGGTTGT	0.582		NaN											1	0	2.89027e-11	0.069288	3.09907e-11	19	36									
SMC3	9126	broad.mit.edu	37	10	112349666	112349666	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr10:112349666G>A	uc001kze.2	+	15	1552	c.1426G>A	c.(1426-1428)GAG>AAG	p.E476K		NM_005445	NP_005436	Q9UQE7	SMC3_HUMAN	structural maintenance of chromosomes 3	476	Potential.				cell division|DNA mediated transformation|DNA repair|meiosis|mitotic metaphase/anaphase transition|mitotic prometaphase|mitotic spindle organization|negative regulation of DNA endoreduplication|signal transduction|sister chromatid cohesion	basement membrane|chromatin|chromosome, centromeric region|cytoplasm|meiotic cohesin complex|nuclear matrix|nucleoplasm|spindle pole	ATP binding|dynein binding|microtubule motor activity|protein heterodimerization activity			ovary(1)|central_nervous_system(1)|skin(1)	3		Breast(234;0.0848)|Lung NSC(174;0.238)		Epithelial(162;0.00206)|all cancers(201;0.0227)|BRCA - Breast invasive adenocarcinoma(275;0.127)		GTGGAGAGAAGAGAATGCAGA	0.358		NaN											0	0	0	0.144211	0	22	41									
WDR11	55717	broad.mit.edu	37	10	122648591	122648591	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr10:122648591G>A	uc010qtf.1	+	17	2361	c.2123G>A	c.(2122-2124)GGA>GAA	p.G708E	WDR11_uc010qte.1_Missense_Mutation_p.G310E|WDR11_uc001lfd.1_Missense_Mutation_p.G226E|WDR11_uc009xzn.2_5'UTR	NM_018117	NP_060587	Q9BZH6	WDR11_HUMAN	bromodomain and WD repeat domain containing 2	708	WD 6.					integral to membrane					0						GTTTTCTAGGGAAGTATGGGT	0.313		NaN											0	0	0	0.069456	0	30	57									
C10orf93	255352	broad.mit.edu	37	10	134750515	134750515	+	Missense_Mutation	SNP	C	C	G			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr10:134750515C>G	uc001llt.1	-	7	781	c.705G>C	c.(703-705)AAG>AAC	p.K235N		NM_173572	NP_775843	Q5SR76	CJ093_HUMAN	hypothetical protein LOC255352	235							binding			pancreas(1)	1		all_cancers(35;1.8e-07)|all_epithelial(44;6.22e-06)|Lung NSC(174;0.0108)|all_lung(145;0.0173)|all_neural(114;0.0726)|Colorectal(31;0.119)|Glioma(114;0.172)|Melanoma(40;0.175)		Epithelial(32;4.28e-05)|OV - Ovarian serous cystadenocarcinoma(35;4.31e-05)|all cancers(32;5.02e-05)		TGGAATTTTTCTTTTCTTCCT	0.274		NaN											0	0	0	0.014758	0	4	13									
DKK3	27122	broad.mit.edu	37	11	11986170	11986170	+	Silent	SNP	G	G	A			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr11:11986170G>A	uc001mju.2	-	7	951	c.894C>T	c.(892-894)ATC>ATT	p.I298I	DKK3_uc010rcf.1_Silent_p.I270I|DKK3_uc001mjv.2_Silent_p.I298I|DKK3_uc001mjw.2_Silent_p.I298I|DKK3_uc010rcg.1_Silent_p.I312I	NM_001018057	NP_001018067	Q9UBP4	DKK3_HUMAN	dickkopf homolog 3 precursor	298					adrenal gland development|anatomical structure morphogenesis|negative regulation of aldosterone biosynthetic process|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cortisol biosynthetic process|negative regulation of transcription, DNA-dependent|Wnt receptor signaling pathway	extracellular space				breast(1)	1				Epithelial(150;0.000502)		TGGGCAGCAGGATCTCCCCAT	0.597		NaN											0	0	0	0.055883	0	19	13									
P2RX3	5024	broad.mit.edu	37	11	57135555	57135555	+	Silent	SNP	C	C	T	rs150261482		TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr11:57135555C>T	uc001nju.2	+	9	991	c.915C>T	c.(913-915)TTC>TTT	p.F305F		NM_002559	NP_002550	P56373	P2RX3_HUMAN	purinergic receptor P2X3	305	Extracellular (Potential).				positive regulation of calcium ion transport into cytosol|positive regulation of calcium-mediated signaling	integral to plasma membrane	ATP binding|extracellular ATP-gated cation channel activity|purinergic nucleotide receptor activity				0						GCATCCGCTTCGACGTGCTGG	0.567		NaN											0	0	0	0.0333	0	12	76									
SLC43A3	29015	broad.mit.edu	37	11	57188794	57188794	+	Silent	SNP	G	G	A			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr11:57188794G>A	uc001nkg.2	-	6	824	c.414C>T	c.(412-414)ATC>ATT	p.I138I	PRG2_uc001nke.2_Silent_p.I37I|SLC43A3_uc001nkh.2_Silent_p.I138I|SLC43A3_uc010rjr.1_Silent_p.I151I|SLC43A3_uc009yme.2_Silent_p.I138I|SLC43A3_uc001nki.2_Silent_p.I138I|SLC43A3_uc009ymf.1_Silent_p.I138I|SLC43A3_uc010rjs.1_Silent_p.I138I|SLC43A3_uc009ymg.1_Silent_p.I151I	NM_014096	NP_054815	Q8NBI5	S43A3_HUMAN	solute carrier family 43, member 3	138	Helical; (Potential).				transmembrane transport	integral to membrane				central_nervous_system(1)	1						TGAGAAACAGGATTCCCCCAA	0.562		NaN											0	0	0	0.0333	0	16	24									
AHNAK	79026	broad.mit.edu	37	11	62297946	62297946	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr11:62297946C>T	uc001ntl.2	-	5	4243	c.3943G>A	c.(3943-3945)GAG>AAG	p.E1315K	AHNAK_uc001ntk.1_Intron	NM_001620	NP_001611	Q09666	AHNK_HUMAN	AHNAK nucleoprotein isoform 1	1315					nervous system development	nucleus	protein binding			ovary(10)|pancreas(4)|skin(4)|upper_aerodigestive_tract(1)	19		Melanoma(852;0.155)				AAGTGCATCTCAGGCATCTTA	0.522		NaN											0	0	0	0.047766	0	8	186									
POLD3	10714	broad.mit.edu	37	11	74340342	74340342	+	Missense_Mutation	SNP	C	C	G			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr11:74340342C>G	uc001ovf.1	+	9	1055	c.980C>G	c.(979-981)CCT>CGT	p.P327R	POLD3_uc009yua.1_Missense_Mutation_p.P221R	NM_006591	NP_006582	Q15054	DPOD3_HUMAN	DNA-directed DNA polymerase delta 3	327					base-excision repair|DNA strand elongation involved in DNA replication|DNA synthesis involved in DNA repair|mismatch repair|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	delta DNA polymerase complex|nucleoplasm	DNA-directed DNA polymerase activity|protein binding			kidney(2)|ovary(1)	3	Breast(11;3.21e-06)					ATCAAACTTCCTGAATCTGAT	0.388		NaN											0	0	0	0.014758	0	4	72									
FOLH1B	219595	broad.mit.edu	37	11	89405073	89405073	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr11:89405073G>A	uc001pda.2	+	5	726	c.200G>A	c.(199-201)GGA>GAA	p.G67E		NM_153696	NP_710163	Q9HBA9	FOH1B_HUMAN	folate hydrolase 1B	67					proteolysis	cytoplasm	dipeptidase activity|metal ion binding|metallopeptidase activity			ovary(3)|skin(2)|central_nervous_system(1)	6						GTCATTCTGGGAGGTCACCGG	0.408		NaN											0	0	0	0.045705	0	17	60									
UBE4A	9354	broad.mit.edu	37	11	118257262	118257262	+	Missense_Mutation	SNP	A	A	G			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr11:118257262A>G	uc001psw.2	+	16	2651	c.2522A>G	c.(2521-2523)CAG>CGG	p.Q841R	UBE4A_uc001psv.2_Missense_Mutation_p.Q848R	NM_004788	NP_004779	Q14139	UBE4A_HUMAN	ubiquitination factor E4A	841					ubiquitin-dependent protein catabolic process	ubiquitin ligase complex	protein binding			ovary(2)|upper_aerodigestive_tract(1)|breast(1)|kidney(1)	5	all_hematologic(175;0.046)	Medulloblastoma(222;0.0425)|Breast(348;0.181)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;3.28e-05)		ATGTTTGGACAGCTGGCACGT	0.468		NaN											0	0	0	0.139131	0	48	154									
CDON	50937	broad.mit.edu	37	11	125889642	125889642	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr11:125889642G>A	uc009zbw.2	-	4	496	c.368C>T	c.(367-369)TCA>TTA	p.S123L	CDON_uc001qdc.3_Missense_Mutation_p.S123L|CDON_uc001qdd.3_RNA|CDON_uc009zbx.2_Missense_Mutation_p.S123L	NM_016952	NP_058648	Q4KMG0	CDON_HUMAN	surface glycoprotein, Ig superfamily member	123	Extracellular (Potential).|Ig-like C2-type 2.				cell adhesion|muscle cell differentiation|positive regulation of muscle cell differentiation	integral to membrane|plasma membrane	protein binding			ovary(3)|skin(2)|breast(1)	6	all_hematologic(175;0.177)	Breast(109;0.00157)|Lung NSC(97;0.0127)|all_lung(97;0.0133)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.51e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0604)		CTTTGTGGATGAACCAAAATC	0.353		NaN											0	0	0	0.132662	0	13	30									
PRB1	5542	broad.mit.edu	37	12	11506602	11506602	+	Silent	SNP	T	T	C			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr12:11506602T>C	uc001qzw.1	-	3	472	c.435A>G	c.(433-435)GGA>GGG	p.G145G	PRB1_uc001qzu.1_Intron|PRB1_uc001qzv.1_Intron	NM_005039	NP_005030	P04280	PRP1_HUMAN	proline-rich protein BstNI subfamily 1 isoform 1	206	15 X 20 AA approximate tandem repeats of P-P-G-K-P-Q-G-P-P-[PAQ]-Q-[GE]-[GD]- [NKS]-[KSQRN]-[PRQS]-[QS] [GPS]-[PQAR]- [PSR].|8.		Missing (in clone CP-4).|Missing (in clone CP-5).|Missing (in allele S).			extracellular region					0			OV - Ovarian serous cystadenocarcinoma(49;0.185)			GGGACTTGTCTCCTTGTGGGG	0.607		NaN											0	0	0	0.09319	0	10	218									
ATF7IP	55729	broad.mit.edu	37	12	14649244	14649244	+	Silent	SNP	C	C	T			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr12:14649244C>T	uc001rbw.2	+	14	3518	c.3360C>T	c.(3358-3360)CTC>CTT	p.L1120L	ATF7IP_uc001rbx.2_Silent_p.L1119L|ATF7IP_uc001rby.3_Silent_p.L1120L|ATF7IP_uc001rca.2_Silent_p.L1120L	NM_018179	NP_060649	Q6VMQ6	MCAF1_HUMAN	activating transcription factor 7 interacting	1120					DNA methylation|interspecies interaction between organisms|positive regulation of transcription, DNA-dependent|regulation of RNA polymerase II transcriptional preinitiation complex assembly|transcription, DNA-dependent		protein binding			lung(3)|ovary(1)|skin(1)	5						GACCTCAGCTCACAGTGCATC	0.393		NaN											0	0	0	0.099896	0	20	38									
HIST4H4	121504	broad.mit.edu	37	12	14923749	14923749	+	Silent	SNP	C	C	T			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr12:14923749C>T	uc001rcf.3	-	1	317	c.270G>A	c.(268-270)GCG>GCA	p.A90A	HIST4H4_uc001rce.2_RNA	NM_175054	NP_778224	P62805	H4_HUMAN	histone cluster 4, H4	90					CenH3-containing nucleosome assembly at centromere|negative regulation of megakaryocyte differentiation|phosphatidylinositol-mediated signaling|telomere maintenance	nucleoplasm|nucleosome	DNA binding|protein binding			ovary(2)	2						GGCGTTTCAGCGCGTACACCA	0.582		NaN									OREG0021698	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.139131	0	52	46									
PKP2	5318	broad.mit.edu	37	12	33021978	33021978	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr12:33021978C>T	uc001rlj.3	-	4	1168	c.1053G>A	c.(1051-1053)ATG>ATA	p.M351I	PKP2_uc001rlk.3_Missense_Mutation_p.M351I|PKP2_uc010skj.1_Missense_Mutation_p.M351I	NM_004572	NP_004563	Q99959	PKP2_HUMAN	plakophilin 2 isoform 2b	351	ARM 1.				cell-cell adhesion	desmosome|integral to membrane|nucleus	binding			ovary(1)|pancreas(1)	2	Lung NSC(5;9.35e-07)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.239)					GCTCCAGAGTCATCTCCATGT	0.527		NaN											0	0	0	0.139131	0	59	54									
MLL2	8085	broad.mit.edu	37	12	49435941	49435941	+	Nonsense_Mutation	SNP	G	G	A			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr12:49435941G>A	uc001rta.3	-	28	6040	c.6040C>T	c.(6040-6042)CAG>TAG	p.Q2014*		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	2014					chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						GTGGACAGCTGGCCCAACTCC	0.577		NaN	N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			0	0	0	0.105934	0	11	13									
SPRYD3	84926	broad.mit.edu	37	12	53460407	53460407	+	Missense_Mutation	SNP	A	A	T			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr12:53460407A>T	uc001sbt.1	-	9	992	c.971T>A	c.(970-972)ATC>AAC	p.I324N	SPRYD3_uc010snw.1_Missense_Mutation_p.I150N	NM_032840	NP_116229	Q8NCJ5	SPRY3_HUMAN	SPRY domain containing 3	324										central_nervous_system(1)	1						ACAGCCCATGATGTCCCCTTT	0.587		NaN									OREG0021856	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.069234	0	9	19									
PAN2	9924	broad.mit.edu	37	12	56720165	56720165	+	Missense_Mutation	SNP	G	G	C			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr12:56720165G>C	uc001skx.2	-	8	1664	c.1291C>G	c.(1291-1293)CTG>GTG	p.L431V	PAN2_uc001skw.2_5'Flank|PAN2_uc001skz.2_Missense_Mutation_p.L431V|PAN2_uc001sky.2_Missense_Mutation_p.L431V	NM_001127460	NP_001120932	Q504Q3	PAN2_HUMAN	PAN2 polyA specific ribonuclease subunit homolog	431					nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA poly(A) tail shortening|ubiquitin-dependent protein catabolic process	cytosol|nucleus	nucleic acid binding|poly(A)-specific ribonuclease activity|ubiquitin thiolesterase activity			ovary(2)|skin(2)|large_intestine(1)|breast(1)	6						ATGGTGCGCAGAATCTCTGCA	0.572		NaN											0	0	0	0.021553	0	4	17									
PLXNC1	10154	broad.mit.edu	37	12	94658921	94658921	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr12:94658921G>A	uc001tdc.2	+	21	3766	c.3517G>A	c.(3517-3519)GTG>ATG	p.V1173M	PLXNC1_uc010sut.1_Missense_Mutation_p.V220M|PLXNC1_uc009zsv.2_Translation_Start_Site	NM_005761	NP_005752	O60486	PLXC1_HUMAN	plexin C1 precursor	1173	Cytoplasmic (Potential).				axon guidance|cell adhesion	integral to membrane|intracellular|plasma membrane	receptor activity|receptor binding			ovary(2)|central_nervous_system(1)	3						CAAGGGTCCCGTGGATGTAAT	0.448		NaN											0	0	0	0.139131	0	109	139									
ANO4	121601	broad.mit.edu	37	12	101442180	101442180	+	Splice_Site	SNP	G	G	A			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr12:101442180G>A	uc010svm.1	+	14	1884	c.1312_splice	c.e14+1	p.A438_splice	ANO4_uc001thw.2_Splice_Site_p.A403_splice|ANO4_uc001thx.2_Splice_Site_p.A438_splice|ANO4_uc001thy.2_Splice_Site_p.A5_splice	NM_178826	NP_849148	Q32M45	ANO4_HUMAN	anoctamin 4							chloride channel complex	chloride channel activity			ovary(4)|skin(2)	6						GCAGTCTGGGGTAAGTGTTCT	0.373		NaN								HNSCC(74;0.22)			0	0	0	0.038395	0	13	39									
MYBPC1	4604	broad.mit.edu	37	12	102069129	102069129	+	Missense_Mutation	SNP	C	C	G			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr12:102069129C>G	uc001tii.2	+	25	2950	c.2848C>G	c.(2848-2850)CTC>GTC	p.L950V	MYBPC1_uc001tig.2_Missense_Mutation_p.L957V|MYBPC1_uc010svq.1_Missense_Mutation_p.L919V|MYBPC1_uc001tih.2_Missense_Mutation_p.L957V|MYBPC1_uc001tij.2_Missense_Mutation_p.L932V|MYBPC1_uc010svr.1_Missense_Mutation_p.L932V|MYBPC1_uc010svs.1_Missense_Mutation_p.L950V|MYBPC1_uc010svt.1_Missense_Mutation_p.L920V|MYBPC1_uc010svu.1_Missense_Mutation_p.L913V|MYBPC1_uc001tik.2_Missense_Mutation_p.L906V|MYBPC1_uc001til.2_5'UTR|MYBPC1_uc001tim.2_5'UTR	NM_206820	NP_996556	Q00872	MYPC1_HUMAN	myosin binding protein C, slow type isoform 3	950	Fibronectin type-III 3.				cell adhesion|muscle filament sliding	cytosol|myofibril|myosin filament	actin binding|structural constituent of muscle|titin binding			ovary(2)|liver(1)|skin(1)	4						AAATGTCGCTCTCACATGGAC	0.478		NaN											0	0	0	0.146539	0	17	39									
FREM2	341640	broad.mit.edu	37	13	39266378	39266378	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr13:39266378G>A	uc001uwv.2	+	1	5206	c.4897G>A	c.(4897-4899)GAT>AAT	p.D1633N		NM_207361	NP_997244	Q5SZK8	FREM2_HUMAN	FRAS1-related extracellular matrix protein 2	1633	Extracellular (Potential).|CSPG 11.				cell communication|homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(7)|pancreas(1)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|skin(1)	11		Lung NSC(96;1.04e-07)|Prostate(109;0.00384)|Breast(139;0.00396)|Lung SC(185;0.0565)|Hepatocellular(188;0.114)		all cancers(112;3.32e-07)|Epithelial(112;1.66e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00154)|BRCA - Breast invasive adenocarcinoma(63;0.00631)|GBM - Glioblastoma multiforme(144;0.0312)		TGTTTTTCCTGATACGGTGTT	0.458		NaN											0	0	0	0.0333	0	16	42									
KIAA1704	55425	broad.mit.edu	37	13	45580434	45580434	+	Missense_Mutation	SNP	C	C	G			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr13:45580434C>G	uc001uzq.2	+	3	422	c.319C>G	c.(319-321)CCA>GCA	p.P107A	KIAA1704_uc010tfo.1_RNA|KIAA1704_uc001uzr.1_Missense_Mutation_p.P107A|KIAA1704_uc001uzs.2_5'UTR|KIAA1704_uc001uzt.2_5'UTR	NM_018559	NP_061029	Q8IXQ4	K1704_HUMAN	hypothetical protein LOC55425	107										pancreas(1)|skin(1)	2		Lung NSC(96;0.00143)|Prostate(109;0.0137)|Breast(139;0.0192)|Lung SC(185;0.0367)|Hepatocellular(98;0.133)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;0.000313)|BRCA - Breast invasive adenocarcinoma(63;0.126)		TGATTCTCCTCCAAGGTGATA	0.279		NaN											0	0	0	0.139131	0	39	124									
ATP7B	540	broad.mit.edu	37	13	52544680	52544680	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr13:52544680C>T	uc001vfw.2	-	3	1648	c.1491G>A	c.(1489-1491)ATG>ATA	p.M497I	ATP7B_uc010adv.2_Intron|ATP7B_uc001vfx.2_Missense_Mutation_p.M497I|ATP7B_uc001vfy.2_Missense_Mutation_p.M386I|ATP7B_uc010tgt.1_Missense_Mutation_p.M497I|ATP7B_uc010tgu.1_Missense_Mutation_p.M497I|ATP7B_uc010tgv.1_Missense_Mutation_p.M497I|ATP7B_uc010tgw.1_Missense_Mutation_p.M465I	NM_000053	NP_000044	P35670	ATP7B_HUMAN	ATPase, Cu++ transporting, beta polypeptide	497	HMA 5.|Cytoplasmic (Potential).				ATP biosynthetic process|cellular copper ion homeostasis|copper ion import|response to copper ion|sequestering of calcium ion	Golgi membrane|integral to plasma membrane|late endosome|mitochondrion	ATP binding|copper ion binding|copper-exporting ATPase activity|protein binding			ovary(1)|central_nervous_system(1)|skin(1)	3		Breast(56;0.000207)|Lung NSC(96;0.000845)|Prostate(109;0.0235)|Hepatocellular(98;0.065)|all_neural(104;0.19)		GBM - Glioblastoma multiforme(99;5.25e-08)		ATGCACAGGTCATGCCTTTGA	0.502		NaN							Wilson_disease				0	0	0	0.139131	0	63	106									
MYCBP2	23077	broad.mit.edu	37	13	77656085	77656085	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr13:77656085G>A	uc001vkf.2	-	65	11057	c.10966C>T	c.(10966-10968)CAT>TAT	p.H3656Y	MYCBP2_uc010aev.2_Missense_Mutation_p.H3060Y|MYCBP2_uc001vke.2_Missense_Mutation_p.H276Y	NM_015057	NP_055872	O75592	MYCB2_HUMAN	MYC binding protein 2	3656					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ligase activity|protein binding|zinc ion binding			ovary(4)|breast(4)|skin(3)|lung(2)|pancreas(1)	14		Breast(118;0.212)|Acute lymphoblastic leukemia(28;0.22)		GBM - Glioblastoma multiforme(99;0.109)		TTGCTCTGATGAAGGAACTGG	0.363		NaN											0	0	0	0.076483	0	23	31									
GPC6	10082	broad.mit.edu	37	13	94958333	94958333	+	Missense_Mutation	SNP	G	G	C			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr13:94958333G>C	uc001vlt.2	+	6	1740	c.1108G>C	c.(1108-1110)GAG>CAG	p.E370Q	GPC6_uc010tig.1_Missense_Mutation_p.E370Q	NM_005708	NP_005699	Q9Y625	GPC6_HUMAN	glypican 6 precursor	370						anchored to membrane|extracellular space|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding				0	all_neural(89;0.0684)|Medulloblastoma(90;0.163)	all_cancers(2;5.48e-07)|all_epithelial(2;5.69e-08)|all_lung(2;2.19e-05)|Lung NSC(4;6.09e-05)|Breast(118;0.0395)|Renal(2;0.0568)|Hepatocellular(115;0.217)				CTACAATCCTGAGGAAAGACC	0.502		NaN											0	0	0	0.076483	0	19	34									
RASA3	22821	broad.mit.edu	37	13	114758015	114758015	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr13:114758015C>T	uc001vui.2	-	22	2322	c.2191G>A	c.(2191-2193)GAG>AAG	p.E731K	RASA3_uc010tkk.1_Missense_Mutation_p.E699K|RASA3_uc001vuj.2_Missense_Mutation_p.E348K	NM_007368	NP_031394	Q14644	RASA3_HUMAN	RAS p21 protein activator 3	731					intracellular signal transduction|negative regulation of Ras protein signal transduction	cytoplasm|intrinsic to internal side of plasma membrane	calcium-release channel activity|metal ion binding|Ras GTPase activator activity			lung(3)|skin(1)	4	Lung NSC(43;0.00814)|all_neural(89;0.0337)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.016)|all_epithelial(44;0.00577)|all_lung(25;0.0173)|Lung NSC(25;0.0634)|Breast(118;0.188)	BRCA - Breast invasive adenocarcinoma(86;0.128)			TAGATACGCTCCGTCTCACGG	0.527		NaN											0	0	0	0.043863	0	15	39									
RNASE13	440163	broad.mit.edu	37	14	21502251	21502251	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr14:21502251G>A	uc001vzj.2	-	2	335	c.197C>T	c.(196-198)TCA>TTA	p.S66L	NDRG2_uc010tll.1_Intron	NM_001012264	NP_001012264	Q5GAN3	RNS13_HUMAN	ribonuclease, RNase A family, 13 precursor	66						extracellular region	nucleic acid binding|pancreatic ribonuclease activity			upper_aerodigestive_tract(1)	1	all_cancers(95;0.000759)		OV - Ovarian serous cystadenocarcinoma(11;6.85e-11)|Epithelial(56;9.49e-09)|all cancers(55;3.84e-08)	GBM - Glioblastoma multiforme(265;0.019)		TGGGCAATCTGAATTTTGCAT	0.428		NaN											0	0	0	0.139131	0	44	37									
MYH7	4625	broad.mit.edu	37	14	23887583	23887583	+	Silent	SNP	C	C	T	rs144465613	byFrequency	TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr14:23887583C>T	uc001wjx.2	-	30	4111	c.4005G>A	c.(4003-4005)TCG>TCA	p.S1335S	MIR208B_hsa-mir-208b|MI0005570_5'Flank	NM_000257	NP_000248	P12883	MYH7_HUMAN	myosin, heavy chain 7, cardiac muscle, beta	1335	Potential.				adult heart development|muscle filament sliding|regulation of heart rate|ventricular cardiac muscle tissue morphogenesis	focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(3)|skin(1)	4	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00725)		CATGCCGGGCCGACTGCAGTG	0.662		NaN											0	0	0	0.02938	0	3	57									
TRIM9	114088	broad.mit.edu	37	14	51561204	51561204	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr14:51561204C>T	uc001wyx.3	-	1	1219	c.454G>A	c.(454-456)GAA>AAA	p.E152K	TRIM9_uc001wyy.2_Missense_Mutation_p.E152K|TRIM9_uc001wyz.3_Missense_Mutation_p.E152K	NM_015163	NP_055978	Q9C026	TRIM9_HUMAN	tripartite motif protein 9 isoform 1	152					proteasomal ubiquitin-dependent protein catabolic process	cell junction|cytoskeleton|dendrite|synaptic vesicle	protein homodimerization activity|ubiquitin-protein ligase activity|zinc ion binding			skin(2)|lung(1)	3	all_epithelial(31;0.00418)|Breast(41;0.148)					ATTACCCCTTCCAGTACGCGA	0.642		NaN											0	0	0	0.021553	0	4	13									
DHRS7	51635	broad.mit.edu	37	14	60622822	60622822	+	Missense_Mutation	SNP	C	C	G			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr14:60622822C>G	uc001xes.2	-	2	366	c.182G>C	c.(181-183)GGA>GCA	p.G61A	C14orf135_uc001xeq.2_Intron|DHRS7_uc001xet.2_Missense_Mutation_p.G11A|DHRS7_uc001xeu.2_Missense_Mutation_p.G61A	NM_016029	NP_057113	Q9Y394	DHRS7_HUMAN	dehydrogenase/reductase (SDR family) member 7	61	NAD (By similarity).						binding|oxidoreductase activity			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(108;0.121)		CTCACCAATTCCACTCGAGGC	0.463		NaN											0	0	0	0.054565	0	29	47									
PCNX	22990	broad.mit.edu	37	14	71445358	71445358	+	Silent	SNP	C	C	T			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr14:71445358C>T	uc001xmo.2	+	6	2750	c.2304C>T	c.(2302-2304)GTC>GTT	p.V768V	PCNX_uc001xmn.3_Silent_p.V768V|PCNX_uc010are.1_Silent_p.V768V	NM_014982	NP_055797	Q96RV3	PCX1_HUMAN	pecanex-like 1	768						integral to membrane				ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(12;0.206)	all cancers(60;0.00835)|BRCA - Breast invasive adenocarcinoma(234;0.00951)|OV - Ovarian serous cystadenocarcinoma(108;0.0417)		AAGATGCAGTCAGTGGAGGTA	0.393		NaN											0	0	0	0.124865	0	35	45									
C14orf102	55051	broad.mit.edu	37	14	90778760	90778760	+	Missense_Mutation	SNP	G	G	C			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr14:90778760G>C	uc001xyi.1	-	4	566	c.535C>G	c.(535-537)CTC>GTC	p.L179V	C14orf102_uc010atp.1_5'UTR|C14orf102_uc001xyj.1_5'UTR	NM_017970	NP_060440	Q9H7Z3	CN102_HUMAN	hypothetical protein LOC55051 isoform 1	179	Potential.						protein binding			ovary(2)|lung(1)	3		all_cancers(154;0.118)		COAD - Colon adenocarcinoma(157;0.218)		CCTCGGTAGAGAGACTTGTAC	0.478		NaN											0	0	0	0.092188	0	31	82									
C14orf129	51527	broad.mit.edu	37	14	96852000	96852000	+	Missense_Mutation	SNP	G	G	C			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr14:96852000G>C	uc001yfj.3	+	4	544	c.399G>C	c.(397-399)TTG>TTC	p.L133F	C14orf129_uc001yfl.2_Missense_Mutation_p.L133F	NM_016472	NP_057556	Q9P0R6	GSKIP_HUMAN	chromosome 14 open reading frame 129	133	Interaction with GSK3B.					cytoplasm	protein binding				0		Melanoma(154;0.226)		Epithelial(152;0.109)|COAD - Colon adenocarcinoma(157;0.205)		TGGAAGCTTTGAAAAGAGATG	0.438		NaN											0	0	0	0.139131	0	66	62									
CYP46A1	10858	broad.mit.edu	37	14	100166436	100166436	+	Silent	SNP	G	G	C			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr14:100166436G>C	uc001ygo.2	+	5	441	c.441G>C	c.(439-441)CGG>CGC	p.R147R	CYP46A1_uc001ygn.1_Silent_p.R109R	NM_006668	NP_006659	Q9Y6A2	CP46A_HUMAN	cytochrome P450, family 46	147					bile acid biosynthetic process|cholesterol catabolic process|nervous system development|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	cholesterol 24-hydroxylase activity|electron carrier activity|heme binding|steroid hydroxylase activity				0		Melanoma(154;0.0866)|all_epithelial(191;0.179)				CCTTCAGCCGGAGGTGAGTGT	0.622		NaN											0	0	0	0.021553	0	5	24									
RAGE	5891	broad.mit.edu	37	14	102729905	102729905	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr14:102729905C>T	uc001ylm.2	-	4	487	c.261G>A	c.(259-261)ATG>ATA	p.M87I	RAGE_uc010txv.1_Missense_Mutation_p.M57I|RAGE_uc001yln.2_5'UTR	NM_014226	NP_055041	Q9UQ07	MOK_HUMAN	MAPK/MAK/MRK overlapping kinase	87	Protein kinase.				signal transduction	Golgi apparatus	ATP binding|cyclin-dependent protein kinase activity|protein binding			ovary(2)|breast(1)|central_nervous_system(1)	4						CATAAATATTCATGTCCATAA	0.308		NaN											0	0	0	0.132662	0	10	33									
TRAF3	7187	broad.mit.edu	37	14	103369714	103369714	+	Silent	SNP	G	G	A			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr14:103369714G>A	uc001ymc.1	+	11	1436	c.1083G>A	c.(1081-1083)GTG>GTA	p.V361V	TRAF3_uc001yme.1_Silent_p.V336V|TRAF3_uc001ymd.1_Silent_p.V361V|TRAF3_uc010txy.1_Silent_p.V278V|TRAF3_uc001ymf.1_Silent_p.V94V	NM_145725	NP_663777	Q13114	TRAF3_HUMAN	TNF receptor-associated factor 3 isoform 1	361					apoptosis|induction of apoptosis|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production|regulation of defense response to virus|regulation of interferon-beta production|regulation of proteolysis|toll-like receptor signaling pathway|tumor necrosis factor-mediated signaling pathway	CD40 receptor complex|cytosol|endosome|internal side of plasma membrane|mitochondrion	signal transducer activity|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|lung(1)|breast(1)	3		all_cancers(154;7.87e-06)|all_epithelial(191;0.0024)		Epithelial(152;9.92e-24)|all cancers(159;2.23e-21)|OV - Ovarian serous cystadenocarcinoma(161;7.85e-12)|Colorectal(3;0.0971)		AGAACCGCGTGACCGAGCTGG	0.652		NaN											0	0	0	0.11126	0	37	45									
KIF26A	26153	broad.mit.edu	37	14	104640516	104640516	+	Missense_Mutation	SNP	T	T	A			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr14:104640516T>A	uc001yos.3	+	11	2062	c.2062T>A	c.(2062-2064)TCC>ACC	p.S688T		NM_015656	NP_056471	Q9ULI4	KI26A_HUMAN	kinesin family member 26A	688					blood coagulation|enteric nervous system development|microtubule-based movement|negative regulation of signal transduction|regulation of cell growth by extracellular stimulus	cytosol|microtubule	ATP binding|microtubule binding|microtubule motor activity			pancreas(1)	1		all_cancers(154;0.109)|Melanoma(154;0.0525)|all_epithelial(191;0.0767)	Epithelial(46;0.152)	Epithelial(152;0.161)		GCTGCGTGAATCCCTGGCCAC	0.687		NaN											0	0	0	0.021553	0	3	7									
AHNAK2	113146	broad.mit.edu	37	14	105409457	105409457	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr14:105409457C>T	uc010axc.1	-	7	12451	c.12331G>A	c.(12331-12333)GAT>AAT	p.D4111N	AHNAK2_uc001ypx.2_Missense_Mutation_p.D4011N	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	4111						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			TGCACACCATCCAGCTTTGCT	0.577		NaN											0	0	0	0.055883	0	17	332									
ATP10A	57194	broad.mit.edu	37	15	25959383	25959383	+	Silent	SNP	C	C	T			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr15:25959383C>T	uc010ayu.2	-	10	1888	c.1782G>A	c.(1780-1782)AGG>AGA	p.R594R		NM_024490	NP_077816	O60312	AT10A_HUMAN	ATPase, class V, type 10A	594	Cytoplasmic (Potential).				ATP biosynthetic process|regulation of cell shape	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			pancreas(2)|ovary(1)|breast(1)|liver(1)	5		all_cancers(20;5.16e-25)|all_lung(180;1.51e-14)|Acute lymphoblastic leukemia(1;2.53e-05)|all_hematologic(1;0.000267)|Breast(32;0.00125)		all cancers(64;9.48e-07)|Epithelial(43;1.69e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0252)|Lung(196;0.244)		CAAACCTCACCCTCACCTGCA	0.602		NaN											0	0	0	0.069288	0	19	26									
WDR72	256764	broad.mit.edu	37	15	54003115	54003115	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr15:54003115C>T	uc002acj.2	-	9	935	c.893G>A	c.(892-894)AGA>AAA	p.R298K	WDR72_uc010bfi.1_Missense_Mutation_p.R298K	NM_182758	NP_877435	Q3MJ13	WDR72_HUMAN	WD repeat domain 72	298										lung(1)|skin(1)	2				all cancers(107;0.0511)		TTTAAGCACTCTTCCATCAGC	0.388		NaN											0	0	0	0.045705	0	26	30									
TBC1D2B	23102	broad.mit.edu	37	15	78290635	78290635	+	Missense_Mutation	SNP	C	C	T	rs117285325	by1000genomes	TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr15:78290635C>T	uc002bcy.3	-	13	2759	c.2759G>A	c.(2758-2760)CGA>CAA	p.R920Q	TBC1D2B_uc010bla.2_Missense_Mutation_p.D903N	NM_144572	NP_653173	Q9UPU7	TBD2B_HUMAN	TBC1 domain family, member 2B isoform a	920						intracellular	protein binding|Rab GTPase activator activity	p.D903N(1)		ovary(1)|large_intestine(1)|breast(1)	3						GTAGGCGCGTCGGTTCCGGAT	0.617		NaN											0	0	0	0.02938	0	4	15									
MEFV	4210	broad.mit.edu	37	16	3294272	3294272	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr16:3294272C>T	uc002cun.1	-	8	1781	c.1741G>A	c.(1741-1743)GAA>AAA	p.E581K		NM_000243	NP_000234	O15553	MEFV_HUMAN	Mediterranean fever protein	581	B30.2/SPRY.				inflammatory response	cytoplasm|microtubule|microtubule associated complex|nucleus	actin binding|zinc ion binding			central_nervous_system(2)|skin(2)|ovary(1)|lung(1)	6					Colchicine(DB01394)	ATTTCCATTTCTGAACGCAGG	0.522		NaN											0	0	0	0.116897	0	24	26									
CLEC16A	23274	broad.mit.edu	37	16	11076791	11076791	+	Silent	SNP	G	G	T			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr16:11076791G>T	uc002dao.2	+	10	1244	c.1014G>T	c.(1012-1014)CTG>CTT	p.L338L	CLEC16A_uc002dan.3_Silent_p.L336L	NM_015226	NP_056041	Q2KHT3	CL16A_HUMAN	C-type lectin domain family 16, member A	338										ovary(1)|central_nervous_system(1)	2						AAGTCATTCTGAATGGTGATC	0.428		NaN											1	0	4.36969e-10	0.105934	4.65001e-10	10	39									
ABCC1	4363	broad.mit.edu	37	16	16180769	16180769	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr16:16180769C>T	uc010bvi.2	+	18	2556	c.2381C>T	c.(2380-2382)CCC>CTC	p.P794L	ABCC1_uc010bvj.2_Missense_Mutation_p.P735L|ABCC1_uc010bvk.2_Intron|ABCC1_uc010bvl.2_Missense_Mutation_p.P794L|ABCC1_uc010bvm.2_Intron|ABCC1_uc002del.3_Missense_Mutation_p.P678L	NM_004996	NP_004987	P33527	MRP1_HUMAN	ATP-binding cassette, sub-family C, member 1	794	ABC transporter 1.|Cytoplasmic.				hormone biosynthetic process|leukotriene biosynthetic process|prostanoid metabolic process|response to drug	Golgi apparatus|integral to plasma membrane|membrane fraction|nucleus	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(4)	4					Daunorubicin(DB00694)|Glibenclamide(DB01016)|Probenecid(DB01032)|Saquinavir(DB01232)|Sulfinpyrazone(DB01138)	TTCGATGATCCCCTCTCAGCA	0.597		NaN											0	0	0	0.049695	0	18	59									
UMOD	7369	broad.mit.edu	37	16	20344666	20344666	+	Silent	SNP	G	G	T			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr16:20344666G>T	uc002dgz.2	-	11	2022	c.1893C>A	c.(1891-1893)CTC>CTA	p.L631L	UMOD_uc002dha.2_Silent_p.L631L|UMOD_uc002dhb.2_Silent_p.L664L	NM_003361	NP_003352	P07911	UROM_HUMAN	uromodulin precursor	631					cellular defense response|negative regulation of cell proliferation	anchored to membrane|apical plasma membrane|basolateral plasma membrane|cilium membrane|extrinsic to membrane|primary cilium|spindle pole	calcium ion binding			ovary(1)|skin(1)	2						AGGTGGCCGAGAGAAGCAGAG	0.542		NaN											1	0	0.000274275	0.047766	0.000281257	6	30									
ACSM5	54988	broad.mit.edu	37	16	20441100	20441100	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr16:20441100G>A	uc002dhe.2	+	8	1249	c.1102G>A	c.(1102-1104)GAA>AAA	p.E368K		NM_017888	NP_060358	Q6NUN0	ACSM5_HUMAN	acyl-CoA synthetase medium-chain family member 5	368	ATP (By similarity).				fatty acid metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|GTP binding|metal ion binding			ovary(2)	2						GGAGCTGTACGAAGGCTATGG	0.617		NaN											0	0	0	0.11911	0	11	51									
CDH1	999	broad.mit.edu	37	16	68863653	68863653	+	Missense_Mutation	SNP	C	C	G			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr16:68863653C>G	uc002ewg.1	+	15	2516	c.2392C>G	c.(2392-2394)CTT>GTT	p.L798V	CDH1_uc010vlj.1_RNA|CDH1_uc010cfg.1_Missense_Mutation_p.L737V	NM_004360	NP_004351	P12830	CADH1_HUMAN	cadherin 1, type 1 preproprotein	798	Cytoplasmic (Potential).				adherens junction organization|cellular component disassembly involved in apoptosis|cellular response to indole-3-methanol|cellular response to lithium ion|homophilic cell adhesion|negative regulation of cell-cell adhesion|positive regulation of transcription factor import into nucleus|positive regulation of transcription, DNA-dependent|regulation of immune response	actin cytoskeleton|aggresome|apical junction complex|catenin complex|cell-cell adherens junction|endosome|focal adhesion|Golgi apparatus|integral to membrane|internal side of plasma membrane|lateral plasma membrane|perinuclear region of cytoplasm	cell adhesion molecule binding|gamma-catenin binding			breast(148)|stomach(71)|biliary_tract(8)|endometrium(3)|soft_tissue(2)|large_intestine(2)|urinary_tract(2)|oesophagus(2)|ovary(2)|thyroid(1)|central_nervous_system(1)|lung(1)	243		all_neural(199;0.0189)|Ovarian(137;0.0563)		Epithelial(162;8.44e-05)|all cancers(182;0.000404)|OV - Ovarian serous cystadenocarcinoma(108;0.000426)|BRCA - Breast invasive adenocarcinoma(181;0.0261)		CCCCCGGTATCTTCCCCGCCC	0.522		NaN	Mis|N|F|S		lobular breast|gastric	gastric			Hereditary_Diffuse_Gastric_Cancer				0	0	0	0.0918	0	19	80									
MPHOSPH6	10200	broad.mit.edu	37	16	82183009	82183009	+	Splice_Site	SNP	C	C	A			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr16:82183009C>A	uc002fgw.2	-	4	305	c.256_splice	c.e4-1	p.K86_splice		NM_005792	NP_005783	Q99547	MPH6_HUMAN	M-phase phosphoprotein 6						M phase of mitotic cell cycle|maturation of 5.8S rRNA	cytoplasm|nucleolus	protein binding|RNA binding				0						GCATCAATTTCTGAAAAATAC	0.398		NaN											1	0	1.90571e-15	0.069456	2.07494e-15	34	35									
KLHDC4	54758	broad.mit.edu	37	16	87760397	87760397	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr16:87760397C>T	uc002fki.2	-	7	779	c.733G>A	c.(733-735)GTC>ATC	p.V245I	KLHDC4_uc010cht.1_Missense_Mutation_p.V64I|KLHDC4_uc002fkj.2_Missense_Mutation_p.V214I|KLHDC4_uc002fkk.2_Missense_Mutation_p.V64I|KLHDC4_uc002fkl.2_Missense_Mutation_p.V188I|KLHDC4_uc010chu.1_Missense_Mutation_p.V64I	NM_017566	NP_060036	Q8TBB5	KLDC4_HUMAN	kelch domain containing 4	245	Kelch 4.									pancreas(2)	2				BRCA - Breast invasive adenocarcinoma(80;0.0283)		CCATAGACGACGATGCCGCCC	0.652		NaN											0	0	0	0.049695	0	15	30									
ANKRD11	29123	broad.mit.edu	37	16	89351818	89351818	+	Missense_Mutation	SNP	T	T	C			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr16:89351818T>C	uc002fmx.1	-	9	1593	c.1132A>G	c.(1132-1134)AAT>GAT	p.N378D	ANKRD11_uc002fmy.1_Missense_Mutation_p.N378D|ANKRD11_uc002fnc.1_Missense_Mutation_p.N378D|ANKRD11_uc002fnb.1_Missense_Mutation_p.N335D	NM_013275	NP_037407	Q6UB99	ANR11_HUMAN	ankyrin repeat domain 11	378						nucleus				ovary(4)|large_intestine(1)|central_nervous_system(1)	6		all_hematologic(23;0.00824)|Colorectal(91;0.0475)		Epithelial(1;5.33e-11)|all cancers(4;2.6e-09)|OV - Ovarian serous cystadenocarcinoma(4;2.29e-07)|BRCA - Breast invasive adenocarcinoma(80;0.0142)		ATAAAACTATTGGATTTCGTT	0.433		NaN											0	0	0	0.050027	0	27	55									
SPATA22	84690	broad.mit.edu	37	17	3352316	3352316	+	Missense_Mutation	SNP	G	G	C			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr17:3352316G>C	uc002fvm.2	-	6	694	c.457C>G	c.(457-459)CAA>GAA	p.Q153E	SPATA22_uc010vrg.1_Missense_Mutation_p.Q137E|SPATA22_uc010vrf.1_Missense_Mutation_p.Q153E|SPATA22_uc002fvn.2_Missense_Mutation_p.Q153E|SPATA22_uc002fvo.2_Missense_Mutation_p.Q153E|SPATA22_uc002fvp.2_Missense_Mutation_p.Q153E|SPATA22_uc010ckf.2_Missense_Mutation_p.Q110E	NM_032598	NP_115987	Q8NHS9	SPT22_HUMAN	spermatogenesis associated 22	153											0						TTTTGTTGTTGAGCTCCCGAA	0.358		NaN											0	0	0	0.092188	0	35	83									
KIF1C	10749	broad.mit.edu	37	17	4905368	4905368	+	Silent	SNP	C	C	G			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr17:4905368C>G	uc002gan.1	+	6	704	c.378C>G	c.(376-378)CTC>CTG	p.L126L		NM_006612	NP_006603	O43896	KIF1C_HUMAN	kinesin family member 1C	126	Kinesin-motor.				microtubule-based movement|retrograde vesicle-mediated transport, Golgi to ER	endoplasmic reticulum|Golgi apparatus|microtubule	ATP binding|microtubule motor activity			breast(2)	2						GTGAGGACCTCTTCTCTCGCG	0.413		NaN											0	0	0	0.117977	0	34	48									
DNAH2	146754	broad.mit.edu	37	17	7722612	7722612	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr17:7722612C>T	uc002giu.1	+	71	10915	c.10901C>T	c.(10900-10902)TCA>TTA	p.S3634L	DNAH2_uc010cnm.1_Missense_Mutation_p.S572L	NM_020877	NP_065928	Q9P225	DYH2_HUMAN	dynein heavy chain domain 3	3634					ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(6)|skin(6)|central_nervous_system(1)	13		all_cancers(10;4.66e-07)|Prostate(122;0.081)				TACCAGTTCTCACTGGATGCC	0.542		NaN											0	0	0	0.132662	0	14	47									
FAM83G	644815	broad.mit.edu	37	17	18907093	18907093	+	Nonsense_Mutation	SNP	G	G	A			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr17:18907093G>A	uc002guw.2	-	2	429	c.262C>T	c.(262-264)CAG>TAG	p.Q88*	SLC5A10_uc002gur.1_Intron|SLC5A10_uc002guu.1_Intron|SLC5A10_uc002gut.1_Intron|SLC5A10_uc002guv.1_Intron|SLC5A10_uc010vyl.1_Intron	NM_001039999	NP_001035088	A6ND36	FA83G_HUMAN	hypothetical protein LOC644815	88										ovary(1)|central_nervous_system(1)	2						TCGGGCCCCTGAGAGGGGCCC	0.701		NaN											0	0	0	0.009096	0	4	4									
PIGS	94005	broad.mit.edu	37	17	26890869	26890869	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr17:26890869C>T	uc002hbo.2	-	4	716	c.343G>A	c.(343-345)GAG>AAG	p.E115K	PIGS_uc002hbn.2_Missense_Mutation_p.E107K|PIGS_uc010wap.1_Missense_Mutation_p.E54K	NM_033198	NP_149975	Q96S52	PIGS_HUMAN	phosphatidylinositol glycan anchor biosynthesis,	115	Lumenal (Potential).				attachment of GPI anchor to protein|C-terminal protein lipidation	GPI-anchor transamidase complex	protein binding			breast(2)|urinary_tract(1)|kidney(1)	4	Lung NSC(42;0.00431)					GCCTCCTCCTCATGGTCCAAA	0.478		NaN											0	0	0	0.139131	0	43	130									
ANKRD13B	124930	broad.mit.edu	37	17	27935029	27935029	+	Silent	SNP	G	G	A			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr17:27935029G>A	uc002hei.2	+	3	389	c.276G>A	c.(274-276)CGG>CGA	p.R92R	ANKRD13B_uc002heh.2_Intron|ANKRD13B_uc002hej.2_RNA	NM_152345	NP_689558	Q86YJ7	AN13B_HUMAN	ankyrin repeat domain 13B	92	ANK 2.										0						TGAGTACCCGGGACCTGGAGC	0.667		NaN											0	0	0	0.105934	0	11	27									
ATAD5	79915	broad.mit.edu	37	17	29162311	29162311	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr17:29162311G>A	uc002hfs.1	+	2	1558	c.1212G>A	c.(1210-1212)ATG>ATA	p.M404I	ATAD5_uc002hft.1_Missense_Mutation_p.M301I	NM_024857	NP_079133	Q96QE3	ATAD5_HUMAN	ATPase family, AAA domain containing 5	404					response to DNA damage stimulus	nucleus	ATP binding|nucleoside-triphosphatase activity			ovary(3)	3		all_hematologic(16;0.0202)|Acute lymphoblastic leukemia(14;0.0238)|Myeloproliferative disorder(56;0.0393)				AGCAATTTATGAAAGCATTTA	0.358		NaN											0	0	0	0.09319	0	12	44									
ATAD5	79915	broad.mit.edu	37	17	29162605	29162605	+	Missense_Mutation	SNP	G	G	C			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr17:29162605G>C	uc002hfs.1	+	2	1852	c.1506G>C	c.(1504-1506)AAG>AAC	p.K502N	ATAD5_uc002hft.1_Missense_Mutation_p.K399N	NM_024857	NP_079133	Q96QE3	ATAD5_HUMAN	ATPase family, AAA domain containing 5	502					response to DNA damage stimulus	nucleus	ATP binding|nucleoside-triphosphatase activity			ovary(3)	3		all_hematologic(16;0.0202)|Acute lymphoblastic leukemia(14;0.0238)|Myeloproliferative disorder(56;0.0393)				ACACTCAAAAGAAAGAAACAA	0.303		NaN											0	0	0	0.105934	0	12	33									
ATAD5	79915	broad.mit.edu	37	17	29162843	29162843	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr17:29162843G>A	uc002hfs.1	+	2	2090	c.1744G>A	c.(1744-1746)GAA>AAA	p.E582K	ATAD5_uc002hft.1_Missense_Mutation_p.E479K	NM_024857	NP_079133	Q96QE3	ATAD5_HUMAN	ATPase family, AAA domain containing 5	582					response to DNA damage stimulus	nucleus	ATP binding|nucleoside-triphosphatase activity			ovary(3)	3		all_hematologic(16;0.0202)|Acute lymphoblastic leukemia(14;0.0238)|Myeloproliferative disorder(56;0.0393)				AGCTGAATCTGAAGCCAGCTT	0.378		NaN											0	0	0	0.0333	0	15	55									
NF1	4763	broad.mit.edu	37	17	29533336	29533336	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr17:29533336C>T	uc002hgg.2	+	12	1672	c.1339C>T	c.(1339-1341)CTT>TTT	p.L447F	NF1_uc002hge.1_Missense_Mutation_p.L447F|NF1_uc002hgf.1_Missense_Mutation_p.L447F|NF1_uc002hgh.2_Missense_Mutation_p.L447F|NF1_uc010csn.1_Missense_Mutation_p.L307F	NM_001042492	NP_001035957	P21359	NF1_HUMAN	neurofibromin isoform 1	447					actin cytoskeleton organization|adrenal gland development|artery morphogenesis|camera-type eye morphogenesis|cerebral cortex development|collagen fibril organization|forebrain astrocyte development|forebrain morphogenesis|heart development|liver development|MAPKKK cascade|metanephros development|myelination in peripheral nervous system|negative regulation of cell migration|negative regulation of endothelial cell proliferation|negative regulation of MAP kinase activity|negative regulation of MAPKKK cascade|negative regulation of neuroblast proliferation|negative regulation of oligodendrocyte differentiation|negative regulation of transcription factor import into nucleus|osteoblast differentiation|phosphatidylinositol 3-kinase cascade|pigmentation|positive regulation of adenylate cyclase activity|positive regulation of neuron apoptosis|Ras protein signal transduction|regulation of blood vessel endothelial cell migration|regulation of bone resorption|response to hypoxia|smooth muscle tissue development|spinal cord development|sympathetic nervous system development|visual learning|wound healing	axon|cytoplasm|dendrite|intrinsic to internal side of plasma membrane|nucleus	protein binding|Ras GTPase activator activity	p.?(2)		soft_tissue(159)|central_nervous_system(56)|lung(28)|large_intestine(27)|haematopoietic_and_lymphoid_tissue(18)|ovary(18)|autonomic_ganglia(12)|breast(3)|skin(3)|stomach(2)|thyroid(1)|prostate(1)|kidney(1)|pancreas(1)	330		all_cancers(10;1.29e-12)|all_epithelial(10;0.00347)|all_hematologic(16;0.00556)|Acute lymphoblastic leukemia(14;0.00593)|Breast(31;0.014)|Myeloproliferative disorder(56;0.0255)|all_lung(9;0.0321)|Lung NSC(157;0.0659)		UCEC - Uterine corpus endometrioid carcinoma (4;4.38e-05)|all cancers(4;1.64e-26)|Epithelial(4;9.15e-23)|OV - Ovarian serous cystadenocarcinoma(4;3.58e-21)|GBM - Glioblastoma multiforme(4;0.00146)		TGGTGAAACACTTCATAAAGC	0.413		NaN	D|Mis|N|F|S|O		neurofibroma|glioma	neurofibroma|glioma			Neurofibromatosis_type_1	TCGA GBM(6;<1E-08)|TSP Lung(7;0.0071)|TCGA Ovarian(3;0.0088)			0	0	0	0.139131	0	40	90									
NF1	4763	broad.mit.edu	37	17	29557904	29557904	+	Nonsense_Mutation	SNP	C	C	G			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08			C	G	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr17:29557904C>G	uc002hgg.2	+	24	3491	c.3158C>G	c.(3157-3159)TCA>TGA	p.S1053*	NF1_uc002hgh.2_Nonsense_Mutation_p.S1053*|NF1_uc010csn.1_Nonsense_Mutation_p.S913*|NF1_uc002hgi.1_Nonsense_Mutation_p.S86*	NM_001042492	NP_001035957	P21359	NF1_HUMAN	neurofibromin isoform 1	1053					actin cytoskeleton organization|adrenal gland development|artery morphogenesis|camera-type eye morphogenesis|cerebral cortex development|collagen fibril organization|forebrain astrocyte development|forebrain morphogenesis|heart development|liver development|MAPKKK cascade|metanephros development|myelination in peripheral nervous system|negative regulation of cell migration|negative regulation of endothelial cell proliferation|negative regulation of MAP kinase activity|negative regulation of MAPKKK cascade|negative regulation of neuroblast proliferation|negative regulation of oligodendrocyte differentiation|negative regulation of transcription factor import into nucleus|osteoblast differentiation|phosphatidylinositol 3-kinase cascade|pigmentation|positive regulation of adenylate cyclase activity|positive regulation of neuron apoptosis|Ras protein signal transduction|regulation of blood vessel endothelial cell migration|regulation of bone resorption|response to hypoxia|smooth muscle tissue development|spinal cord development|sympathetic nervous system development|visual learning|wound healing	axon|cytoplasm|dendrite|intrinsic to internal side of plasma membrane|nucleus	protein binding|Ras GTPase activator activity	p.?(2)		soft_tissue(159)|central_nervous_system(56)|lung(28)|large_intestine(27)|haematopoietic_and_lymphoid_tissue(18)|ovary(18)|autonomic_ganglia(12)|breast(3)|skin(3)|stomach(2)|thyroid(1)|prostate(1)|kidney(1)|pancreas(1)	330		all_cancers(10;1.29e-12)|all_epithelial(10;0.00347)|all_hematologic(16;0.00556)|Acute lymphoblastic leukemia(14;0.00593)|Breast(31;0.014)|Myeloproliferative disorder(56;0.0255)|all_lung(9;0.0321)|Lung NSC(157;0.0659)		UCEC - Uterine corpus endometrioid carcinoma (4;4.38e-05)|all cancers(4;1.64e-26)|Epithelial(4;9.15e-23)|OV - Ovarian serous cystadenocarcinoma(4;3.58e-21)|GBM - Glioblastoma multiforme(4;0.00146)		ATGGGAACATCAAACCAAGCA	0.358		NaN	D|Mis|N|F|S|O		neurofibroma|glioma	neurofibroma|glioma			Neurofibromatosis_type_1	TCGA GBM(6;<1E-08)|TSP Lung(7;0.0071)|TCGA Ovarian(3;0.0088)			0	0	0	0.02938	0	4	12									
SPACA3	124912	broad.mit.edu	37	17	31322626	31322626	+	Silent	SNP	C	C	T			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr17:31322626C>T	uc002hhs.1	+	2	309	c.234C>T	c.(232-234)CTC>CTT	p.L78L	SPACA3_uc010cte.1_RNA	NM_173847	NP_776246	Q8IXA5	SACA3_HUMAN	sperm acrosome associated 3	78	Helical; Signal-anchor for type II membrane protein; (Potential).				cell wall macromolecule catabolic process|defense response to Gram-positive bacterium|monocyte activation|peptidoglycan catabolic process|positive regulation of macrophage activation|positive regulation of phagocytosis|response to virus	acrosomal membrane|extracellular region|integral to membrane|lysosome	bacterial cell surface binding|lysozyme activity|protein binding			ovary(2)	2			BRCA - Breast invasive adenocarcinoma(9;0.193)			TCTGTCTGCTCAGCTGCCTGC	0.622		NaN											0	0	0	0.038395	0	17	47									
TUBG1	7283	broad.mit.edu	37	17	40762134	40762134	+	Missense_Mutation	SNP	G	G	C			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr17:40762134G>C	uc002ian.2	+	2	456	c.58G>C	c.(58-60)GAG>CAG	p.E20Q	FAM134C_uc002ial.2_5'Flank|FAM134C_uc010wgq.1_5'Flank|FAM134C_uc002iam.1_5'Flank|FAM134C_uc010cyk.1_Intron	NM_001070	NP_001061	P23258	TBG1_HUMAN	tubulin, gamma 1	20					G2/M transition of mitotic cell cycle|meiotic spindle organization|protein polymerization	condensed nuclear chromosome|cytosol|gamma-tubulin complex|polar microtubule	GTP binding|GTPase activity|protein binding|structural constituent of cytoskeleton			ovary(1)	1		Breast(137;0.00116)		BRCA - Breast invasive adenocarcinoma(366;0.129)		AGTTGGGTTCGAGTTCTGGAA	0.627		NaN											0	0	0	0.054565	0	30	59									
BECN1	8678	broad.mit.edu	37	17	40963765	40963765	+	Missense_Mutation	SNP	C	C	G			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr17:40963765C>G	uc002ibo.3	-	11	1227	c.1092G>C	c.(1090-1092)AAG>AAC	p.K364N	BECN1_uc010whb.1_Missense_Mutation_p.K277N|BECN1_uc010whc.1_Intron|BECN1_uc002ibn.2_Missense_Mutation_p.K364N	NM_003766	NP_003757	Q14457	BECN1_HUMAN	beclin 1	364					anti-apoptosis|cell cycle|cellular defense response|cytokinesis|response to virus	membrane	protein binding			ovary(1)	1		Breast(137;0.00104)		BRCA - Breast invasive adenocarcinoma(366;0.0745)		CATGGTCAAACTTGTTGTCCC	0.493		NaN											0	0	0	0.059317	0	29	64									
MPP2	4355	broad.mit.edu	37	17	41958843	41958843	+	Missense_Mutation	SNP	C	C	A			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr17:41958843C>A	uc010wip.1	-	7	988	c.931G>T	c.(931-933)GAT>TAT	p.D311Y	MPP2_uc002ien.1_Missense_Mutation_p.D283Y|MPP2_uc010wim.1_Missense_Mutation_p.D255Y|MPP2_uc002ieo.1_Missense_Mutation_p.D266Y|MPP2_uc010win.1_Missense_Mutation_p.D127Y|MPP2_uc010wio.1_Missense_Mutation_p.D255Y	NM_005374	NP_005365	Q14168	MPP2_HUMAN	palmitoylated membrane protein 2	290	SH3.				signal transduction	cell surface|integral to plasma membrane|membrane fraction	guanylate kinase activity				0		Breast(137;0.00314)		BRCA - Breast invasive adenocarcinoma(366;0.12)		CAGTTGGCATCATCCTGGTTT	0.627		NaN											1	0	1.30916e-28	0.139131	1.45348e-28	37	75									
ACE	1636	broad.mit.edu	37	17	61566090	61566090	+	Missense_Mutation	SNP	G	G	C			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr17:61566090G>C	uc002jau.1	+	16	2409	c.2387G>C	c.(2386-2388)AGA>ACA	p.R796T	ACE_uc002jav.1_Missense_Mutation_p.R222T|ACE_uc010ddv.1_Missense_Mutation_p.R23T|ACE_uc010wpj.1_Missense_Mutation_p.R222T|ACE_uc002jaw.1_RNA|ACE_uc010wpk.1_Missense_Mutation_p.R106T	NM_000789	NP_000780	P12821	ACE_HUMAN	angiotensin I converting enzyme 1 isoform 1	796	Extracellular (Potential).|Peptidase M2 2.				arachidonic acid secretion|hormone catabolic process|kidney development|peptide catabolic process|regulation of smooth muscle cell migration	endosome|external side of plasma membrane|extracellular space|integral to membrane|membrane fraction|plasma membrane	actin binding|bradykinin receptor binding|carboxypeptidase activity|chloride ion binding|drug binding|metallopeptidase activity|peptidyl-dipeptidase activity|zinc ion binding			ovary(2)|upper_aerodigestive_tract(1)|pancreas(1)	4					Benazepril(DB00542)|Captopril(DB01197)|Deserpidine(DB01089)|Enalapril(DB00584)|Fosinopril(DB00492)|Lisinopril(DB00722)|Moexipril(DB00691)|Perindopril(DB00790)|Quinapril(DB00881)|Ramipril(DB00178)|Rescinnamine(DB01180)|Spirapril(DB01348)|Trandolapril(DB00519)	AAGGCGGGGAGAGCCATCCTC	0.562		NaN											0	0	0	0.064281	0	30	45									
HELZ	9931	broad.mit.edu	37	17	65141908	65141908	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr17:65141908C>T	uc010wqk.1	-	21	2910	c.2723G>A	c.(2722-2724)GGA>GAA	p.G908E	HELZ_uc002jfv.3_RNA|HELZ_uc002jfx.3_Missense_Mutation_p.G907E	NM_014877	NP_055692			helicase with zinc finger domain											ovary(1)|pancreas(1)	2	all_cancers(12;1.24e-11)|Breast(2;1.05e-17)|all_epithelial(3;3.87e-13)					TACATCTTCTCCTCGTGCTGT	0.378		NaN											0	0	0	0.047766	0	8	38									
KCNJ2	3759	broad.mit.edu	37	17	68171221	68171221	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr17:68171221C>T	uc010dfg.2	+	2	442	c.41C>T	c.(40-42)TCA>TTA	p.S14L	KCNJ2_uc002jir.2_Missense_Mutation_p.S14L	NM_000891	NP_000882	P63252	IRK2_HUMAN	potassium inwardly-rectifying channel J2	14	Cytoplasmic (By similarity).				synaptic transmission	integral to plasma membrane	inward rectifier potassium channel activity|protein binding				0	Breast(10;1.64e-08)					ATCGTCTCTTCAGAAGAAGAC	0.517		NaN											0	0	0	0.0918	0	19	22									
EPB41L3	23136	broad.mit.edu	37	18	5394743	5394743	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr18:5394743G>A	uc002kmt.1	-	22	3289	c.3203C>T	c.(3202-3204)TCA>TTA	p.S1068L	EPB41L3_uc010wzh.1_Intron|EPB41L3_uc002kmu.1_Missense_Mutation_p.S846L|EPB41L3_uc010dkq.1_Missense_Mutation_p.S737L|EPB41L3_uc002kms.1_Missense_Mutation_p.S303L|EPB41L3_uc010wze.1_Missense_Mutation_p.S373L|EPB41L3_uc010wzf.1_Missense_Mutation_p.S365L|EPB41L3_uc010wzg.1_Missense_Mutation_p.S340L|EPB41L3_uc010dkr.2_Missense_Mutation_p.S460L	NM_012307	NP_036439	Q9Y2J2	E41L3_HUMAN	erythrocyte membrane protein band 4.1-like 3	1068	Carboxyl-terminal (CTD).				cortical actin cytoskeleton organization	cell-cell junction|cytoplasm|cytoskeleton|extrinsic to membrane	actin binding|structural molecule activity			ovary(5)	5						TTTGGTCACTGACATGTCAGG	0.502		NaN											0	0	0	0.099896	0	24	74									
SYT4	6860	broad.mit.edu	37	18	40854029	40854029	+	Missense_Mutation	SNP	G	G	T			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr18:40854029G>T	uc002law.2	-	2	734	c.365C>A	c.(364-366)ACC>AAC	p.T122N	SYT4_uc010dng.2_Intron|SYT4_uc010xcm.1_Missense_Mutation_p.T104N|SYT4_uc010dnh.2_Intron	NM_020783	NP_065834	Q9H2B2	SYT4_HUMAN	synaptotagmin IV	122	Cytoplasmic (Potential).					cell junction|integral to membrane|synaptic vesicle membrane	transporter activity			skin(5)	5						GAGCTTCGGGGTTGCATTCTC	0.433		NaN											1	0	9.78306e-22	0.144211	1.08189e-21	22	49									
CCDC102B	79839	broad.mit.edu	37	18	66504371	66504371	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr18:66504371G>A	uc002lkk.2	+	4	594	c.371G>A	c.(370-372)AGA>AAA	p.R124K	CCDC102B_uc002lki.2_Missense_Mutation_p.R124K|CCDC102B_uc002lkj.1_Missense_Mutation_p.R124K	NM_001093729	NP_001087198	Q68D86	C102B_HUMAN	coiled-coil domain containing 102B	124	Potential.									ovary(1)|lung(1)|skin(1)	3		Esophageal squamous(42;0.0559)|Colorectal(73;0.0604)				AGACAACTCAGAATAAAACTA	0.458		NaN											0	0	0	0.069288	0	18	29									
ZNF57	126295	broad.mit.edu	37	19	2917729	2917729	+	Silent	SNP	G	G	A			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr19:2917729G>A	uc002lwr.2	+	4	1258	c.1110G>A	c.(1108-1110)GGG>GGA	p.G370G	ZNF57_uc010xha.1_Silent_p.G338G	NM_173480	NP_775751	Q68EA5	ZNF57_HUMAN	zinc finger protein 57	370	C2H2-type 8.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|GBM - Glioblastoma multiforme(1328;0.00161)|STAD - Stomach adenocarcinoma(1328;0.18)		AACAATGTGGGAAAGCCTTCA	0.433		NaN											0	0	0	0.115264	0	3	60									
TJP3	27134	broad.mit.edu	37	19	3735874	3735874	+	Silent	SNP	C	C	G			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr19:3735874C>G	uc010xhv.1	+	9	1167	c.1167C>G	c.(1165-1167)CCC>CCG	p.P389P	TJP3_uc010xhs.1_Silent_p.P356P|TJP3_uc010xht.1_Silent_p.P320P|TJP3_uc010xhu.1_Silent_p.P365P|TJP3_uc010xhw.1_Silent_p.P375P	NM_014428	NP_055243	O95049	ZO3_HUMAN	tight junction protein 3	370						tight junction	protein binding			ovary(1)|central_nervous_system(1)|skin(1)	3				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0118)|STAD - Stomach adenocarcinoma(1328;0.18)		CAGAGTTGCCCAGGGAAAGCA	0.512		NaN											0	0	0	0.139131	0	40	92									
DNMT1	1786	broad.mit.edu	37	19	10270402	10270402	+	Missense_Mutation	SNP	G	G	C			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr19:10270402G>C	uc002mng.2	-	16	1344	c.1164C>G	c.(1162-1164)ATC>ATG	p.I388M	DNMT1_uc010xlc.1_Missense_Mutation_p.I404M|DNMT1_uc002mnh.2_Missense_Mutation_p.I283M|DNMT1_uc010xld.1_Missense_Mutation_p.I388M	NM_001379	NP_001370	P26358	DNMT1_HUMAN	DNA (cytosine-5-)-methyltransferase 1 isoform b	388	DNA replication foci-targeting sequence (By similarity).|Homodimerization.|Interaction with the PRC2/EED-EZH2 complex (By similarity).				chromatin modification|maintenance of DNA methylation|negative regulation of histone H3-K9 methylation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of gene expression|positive regulation of histone H3-K4 methylation|transcription, DNA-dependent	nucleus	DNA (cytosine-5-)-methyltransferase activity|DNA binding|transcription factor binding			ovary(2)|prostate(1)|lung(1)|breast(1)|skin(1)	6			OV - Ovarian serous cystadenocarcinoma(20;1.59e-09)|Epithelial(33;2.86e-06)|all cancers(31;6.68e-06)		Azacitidine(DB00928)|Decitabine(DB01262)|Flucytosine(DB01099)|Ifosfamide(DB01181)|Procainamide(DB01035)	TGGCATCAAAGATGGACAGCT	0.537		NaN											0	0	0	0.049695	0	18	60									
ZNF491	126069	broad.mit.edu	37	19	11916930	11916930	+	Missense_Mutation	SNP	G	G	C			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr19:11916930G>C	uc002mso.1	+	3	447	c.162G>C	c.(160-162)AGG>AGC	p.R54S		NM_152356	NP_689569	Q8N8L2	ZN491_HUMAN	zinc finger protein 491	54	C2H2-type 1; degenerate.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2						CCTTTAATAGGAACATCAGAA	0.393		NaN											0	0	0	0.043863	0	16	31									
ZNF443	10224	broad.mit.edu	37	19	12542283	12542283	+	Missense_Mutation	SNP	A	A	G			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr19:12542283A>G	uc002mtu.2	-	4	901	c.703T>C	c.(703-705)TCT>CCT	p.S235P		NM_005815	NP_005806	Q9Y2A4	ZN443_HUMAN	zinc finger protein 443	235	C2H2-type 4.				induction of apoptosis|regulation of transcription, DNA-dependent|response to stress|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			pancreas(1)	1						CTGTAAAAAGAAAAGGCTTTA	0.378		NaN											0	0	0	0.058154	0	7	133									
ZNF443	10224	broad.mit.edu	37	19	12542302	12542302	+	Silent	SNP	C	C	T			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr19:12542302C>T	uc002mtu.2	-	4	882	c.684G>A	c.(682-684)AAG>AAA	p.K228K		NM_005815	NP_005806	Q9Y2A4	ZN443_HUMAN	zinc finger protein 443	228	C2H2-type 4.				induction of apoptosis|regulation of transcription, DNA-dependent|response to stress|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			pancreas(1)	1						TAGAACACTGCTTACATTCAT	0.373		NaN											0	0	0	0.02938	0	6	123									
ZNF737	100129842	broad.mit.edu	37	19	20727612	20727612	+	Nonsense_Mutation	SNP	G	G	C			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr19:20727612G>C	uc002npa.2	-	4	1577	c.1397C>G	c.(1396-1398)TCA>TGA	p.S466*		NM_001159293	NP_001152765	C9JHM3	C9JHM3_HUMAN	zinc finger protein 737	466					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding			ovary(1)	1						AGTAAGGTGTGAGGACGAGTT	0.413		NaN											0	0	0	0.064281	0	31	54									
SPRED3	399473	broad.mit.edu	37	19	38881044	38881044	+	Silent	SNP	C	C	T			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr19:38881044C>T	uc002oim.2	+	1	106	c.102C>T	c.(100-102)GTC>GTT	p.V34V	GGN_uc002oij.1_5'Flank|GGN_uc002oik.1_5'Flank|GGN_uc010efy.1_5'Flank|SPRED3_uc002oil.1_Silent_p.V34V	NM_001042522	NP_001035987	Q2MJR0	SPRE3_HUMAN	sprouty-related, EVH1 domain containing 3	34	WH1.				multicellular organismal development					central_nervous_system(2)|lung(1)|skin(1)	4	all_cancers(60;3.4e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)			TGTGTCGGGTCCGAGGGGCCA	0.731		NaN											0	0	0	0.009096	0	4	8									
SERTAD1	29950	broad.mit.edu	37	19	40928872	40928872	+	Silent	SNP	G	G	C			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr19:40928872G>C	uc002ont.3	-	2	741	c.582C>G	c.(580-582)CTC>CTG	p.L194L		NM_013376	NP_037508	Q9UHV2	SRTD1_HUMAN	SERTA domain containing 1	194					positive regulation of cell proliferation|regulation of cyclin-dependent protein kinase activity|regulation of transcription, DNA-dependent|transcription, DNA-dependent						0			Lung(22;6.24e-05)|LUSC - Lung squamous cell carcinoma(20;0.000384)			GGCCTGGTTTGAGGCCCTCAG	0.582		NaN											0	0	0	0.009096	0	4	6									
CYP2B6	1555	broad.mit.edu	37	19	41518309	41518309	+	Missense_Mutation	SNP	G	G	C			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr19:41518309G>C	uc002opr.1	+	7	1078	c.1071G>C	c.(1069-1071)CAG>CAC	p.Q357H	CYP2A7_uc002opo.2_Intron|CYP2B6_uc010xvu.1_Missense_Mutation_p.Q157H	NM_000767	NP_000758	P20813	CP2B6_HUMAN	cytochrome P450, family 2, subfamily B,	357					cellular ketone metabolic process|exogenous drug catabolic process|steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding			ovary(1)|skin(1)	2			LUSC - Lung squamous cell carcinoma(20;0.00322)		Bupropion(DB01156)|Butalbital(DB00241)|Carbamazepine(DB00564)|Clopidogrel(DB00758)|Cyclophosphamide(DB00531)|Efavirenz(DB00625)|Ifosfamide(DB01181)|Memantine(DB01043)|Meperidine(DB00454)|Mephenytoin(DB00532)|Methadone(DB00333)|Methylphenobarbital(DB00849)|Midazolam(DB00683)|Nelfinavir(DB00220)|Nevirapine(DB00238)|Nicotine(DB00184)|Orphenadrine(DB01173)|Phenytoin(DB00252)|Propofol(DB00818)|Ritonavir(DB00503)|Selegiline(DB01037)|Sertraline(DB01104)|Ticlopidine(DB00208)|Troleandomycin(DB01361)	ATGAGATTCAGAGATTTTCCG	0.537		NaN											0	0	0	0.045705	0	26	45									
C19orf73	55150	broad.mit.edu	37	19	49622031	49622031	+	Silent	SNP	G	G	A			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr19:49622031G>A	uc002pmq.3	-	1	367	c.249C>T	c.(247-249)TCC>TCT	p.S83S	PPFIA3_uc002pmr.2_5'Flank|PPFIA3_uc010yai.1_5'Flank	NM_018111	NP_060581	Q9NVV2	CS073_HUMAN	hypothetical protein LOC55150	83										large_intestine(1)	1						AAACGCAGCCGGAGCCAGTGG	0.657		NaN											0	0	0	0.009096	0	3	83									
KLK6	5653	broad.mit.edu	37	19	51470539	51470539	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr19:51470539C>T	uc002pui.2	-	4	343	c.83G>A	c.(82-84)TGC>TAC	p.C28Y	KLK6_uc010eoj.2_Missense_Mutation_p.C28Y|KLK6_uc002puh.2_Missense_Mutation_p.C37Y|KLK6_uc002puj.2_5'UTR|KLK6_uc010ycn.1_Intron|KLK6_uc002pul.2_Missense_Mutation_p.C28Y|KLK6_uc002pum.2_Intron	NM_001012964	NP_001012982	Q92876	KLK6_HUMAN	kallikrein-related peptidase 6 isoform A	28	Peptidase S1.				amyloid precursor protein metabolic process|central nervous system development|collagen catabolic process|hormone metabolic process|myelination|positive regulation of G-protein coupled receptor protein signaling pathway|protein autoprocessing|proteolysis|regulation of cell differentiation|tissue regeneration	endoplasmic reticulum|extracellular region|microsome|mitochondrion|nucleolus	protein binding|serine-type endopeptidase activity				0		all_neural(266;0.026)		OV - Ovarian serous cystadenocarcinoma(262;0.00372)|GBM - Glioblastoma multiforme(134;0.00871)		TGTCTTGTCGCAGGGTCCGCC	0.587		NaN											0	0	0	0.105934	0	10	25									
ZNF845	91664	broad.mit.edu	37	19	53855196	53855196	+	Missense_Mutation	SNP	T	T	C			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr19:53855196T>C	uc010ydv.1	+	4	1385	c.1268T>C	c.(1267-1269)ATG>ACG	p.M423T	ZNF845_uc010ydw.1_Missense_Mutation_p.M423T	NM_138374	NP_612383	Q96IR2	ZN845_HUMAN	zinc finger protein 845	423	C2H2-type 8.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						TTCAGTCAGATGTCATCCCTT	0.408		NaN											0	0	0	0.058154	0	5	171									
ZNF761	388561	broad.mit.edu	37	19	53958360	53958360	+	Nonsense_Mutation	SNP	C	C	A			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr19:53958360C>A	uc010eqp.2	+	7	1057	c.599C>A	c.(598-600)TCA>TAA	p.S200*	ZNF761_uc010ydy.1_Nonsense_Mutation_p.S146*|ZNF761_uc002qbt.1_Nonsense_Mutation_p.S146*	NM_001008401	NP_001008401	Q86XN6	ZN761_HUMAN	zinc finger protein 761	200					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.S146*(1)		ovary(1)	1				GBM - Glioblastoma multiforme(134;0.00786)		TGGAATTCTTCATTACTCACA	0.373		NaN											1	0	2.46105e-21	0.045705	2.711e-21	31	62									
LILRA3	11026	broad.mit.edu	37	19	54803053	54803053	+	Nonsense_Mutation	SNP	C	C	T			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr19:54803053C>T	uc002qfd.2	-	4	689	c.624G>A	c.(622-624)TGG>TGA	p.W208*	LILRA6_uc002qew.1_Intron|LILRA3_uc010erk.2_Intron	NM_006865	NP_006856	Q8N6C8	LIRA3_HUMAN	leukocyte immunoglobulin-like receptor,	208	Ig-like C2-type 2.				defense response	extracellular region|plasma membrane	antigen binding|receptor activity			ovary(1)	1	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		TGGGTAGAGACCACACATAGG	0.617		NaN											0	0	0	0.064281	0	30	27									
NLRP2	55655	broad.mit.edu	37	19	55494608	55494608	+	Missense_Mutation	SNP	C	C	G			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr19:55494608C>G	uc002qij.2	+	6	1628	c.1542C>G	c.(1540-1542)TTC>TTG	p.F514L	NLRP2_uc010yfp.1_Missense_Mutation_p.F491L|NLRP2_uc010esn.2_Missense_Mutation_p.F490L|NLRP2_uc010eso.2_Missense_Mutation_p.F511L|NLRP2_uc010esp.2_Missense_Mutation_p.F492L	NM_017852	NP_060322	Q9NX02	NALP2_HUMAN	NLR family, pyrin domain containing 2	514	NACHT.				apoptosis|positive regulation of caspase activity|positive regulation of interleukin-1 beta secretion	cytoplasm	ATP binding|Pyrin domain binding			ovary(1)|skin(1)	2			BRCA - Breast invasive adenocarcinoma(297;0.163)	GBM - Glioblastoma multiforme(193;0.028)		CTGCCCTGTTCTACACCCTGG	0.562		NaN											0	0	0	0.080422	0	31	49									
A1BG	1	broad.mit.edu	37	19	58863655	58863655	+	Missense_Mutation	SNP	C	C	G			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr19:58863655C>G	uc002qsd.3	-	4	669	c.607G>C	c.(607-609)GAG>CAG	p.E203Q	NCRNA00181_uc002qse.2_Intron|A1BG_uc002qsf.1_RNA|NCRNA00181_uc002qsg.2_RNA	NM_130786	NP_570602	P04217	A1BG_HUMAN	alpha 1B-glycoprotein precursor	203	Ig-like V-type 2.					extracellular region					0		all_cancers(17;3.04e-16)|all_epithelial(17;7.77e-12)|Lung NSC(17;3.25e-05)|Colorectal(82;5.46e-05)|all_lung(17;0.000129)|all_neural(62;0.0182)|Ovarian(87;0.0443)|Breast(46;0.0889)|Renal(17;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0269)		TCACCGAGCTCCTCAATGGTC	0.607		NaN											0	0	0	0.069288	0	19	38									
NTSR2	23620	broad.mit.edu	37	2	11802346	11802346	+	Silent	SNP	G	G	A			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr2:11802346G>A	uc002rbq.3	-	2	719	c.645C>T	c.(643-645)TTC>TTT	p.F215F		NM_012344	NP_036476	O95665	NTR2_HUMAN	neurotensin receptor 2	215	Extracellular (Potential).				sensory perception	integral to plasma membrane					0	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.129)|OV - Ovarian serous cystadenocarcinoma(76;0.24)	Levocabastine(DB01106)	AGGGGAGCACGAAGGACACCA	0.642		NaN											0	0	0	0.058154	0	8	141									
CAPN13	92291	broad.mit.edu	37	2	30976054	30976054	+	Missense_Mutation	SNP	G	G	C			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr2:30976054G>C	uc002rnn.2	-	10	1128	c.952C>G	c.(952-954)CAA>GAA	p.Q318E	CAPN13_uc002rnp.1_Missense_Mutation_p.Q318E	NM_144575	NP_653176	Q6MZZ7	CAN13_HUMAN	calpain 13	318	Calpain catalytic.				proteolysis	intracellular	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity			large_intestine(1)|ovary(1)	2	all_hematologic(175;0.0487)|Acute lymphoblastic leukemia(172;0.155)					TGGAAATCTTGACACGACATC	0.453		NaN											0	0	0	0.099896	0	21	45									
PRKD3	23683	broad.mit.edu	37	2	37481367	37481367	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr2:37481367G>A	uc002rqd.2	-	17	3034	c.2479C>T	c.(2479-2481)CTT>TTT	p.L827F		NM_005813	NP_005804	O94806	KPCD3_HUMAN	protein kinase D3	827	Protein kinase.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction	cytoplasm|membrane|nucleus	ATP binding|metal ion binding|protein binding|protein kinase C activity			lung(2)|ovary(1)|central_nervous_system(1)	4		all_hematologic(82;0.21)				GGATGACTAAGAGATTTGTCA	0.368		NaN											0	0	0	0.108266	0	23	30									
THUMPD2	80745	broad.mit.edu	37	2	39964112	39964112	+	Silent	SNP	A	A	T			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr2:39964112A>T	uc002rru.2	-	10	1312	c.1275T>A	c.(1273-1275)CCT>CCA	p.P425P	THUMPD2_uc002rrv.2_RNA|THUMPD2_uc010ynt.1_Silent_p.P316P	NM_025264	NP_079540	Q9BTF0	THUM2_HUMAN	THUMP domain containing 2	425							methyltransferase activity			skin(1)	1		all_hematologic(82;0.248)				TGGAATTGAAAGGGATGTTGC	0.418		NaN											0	0	0	0.059317	0	36	62									
SPTBN1	6711	broad.mit.edu	37	2	54895611	54895611	+	Missense_Mutation	SNP	G	G	C	rs150630405	byFrequency	TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr2:54895611G>C	uc002rxu.2	+	36	7249	c.7000G>C	c.(7000-7002)GTC>CTC	p.V2334L	SPTBN1_uc010you.1_Missense_Mutation_p.V324L	NM_003128	NP_003119	Q01082	SPTB2_HUMAN	spectrin, beta, non-erythrocytic 1 isoform 1	2334					actin filament capping|axon guidance	cytosol|nucleolus|plasma membrane|sarcomere|spectrin	actin binding|calmodulin binding|protein binding|structural constituent of cytoskeleton			ovary(3)|breast(2)|central_nervous_system(2)|skin(1)	8			Lung(47;0.24)			CACCAGCGTCGTCACCATCAC	0.567		NaN											0	0	0	0.054565	0	24	28									
CD207	50489	broad.mit.edu	37	2	71060100	71060100	+	Nonsense_Mutation	SNP	C	C	T			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr2:71060100C>T	uc002shg.2	-	4	695	c.648G>A	c.(646-648)TGG>TGA	p.W216*		NM_015717	NP_056532	Q9UJ71	CLC4K_HUMAN	CD207 antigen, langerin	216	C-type lectin.|Extracellular (Potential).				defense response to virus	endocytic vesicle|integral to membrane	mannose binding			ovary(1)|lung(1)	2						CGGCACTATACCAGGTCTTTG	0.478		NaN											0	0	0	0.146539	0	15	36									
MOGS	7841	broad.mit.edu	37	2	74691751	74691751	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr2:74691751G>A	uc010ffj.2	-	2	614	c.451C>T	c.(451-453)CAC>TAC	p.H151Y	MOGS_uc010ffh.2_5'Flank|MOGS_uc010yrt.1_Missense_Mutation_p.H32Y|MOGS_uc010ffi.2_Missense_Mutation_p.H45Y|MOGS_uc010yru.1_Intron	NM_006302	NP_006293	Q13724	MOGS_HUMAN	mannosyl-oligosaccharide glucosidase isoform 1	151	Lumenal (Potential).				oligosaccharide metabolic process|post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane|integral to membrane|membrane fraction	mannosyl-oligosaccharide glucosidase activity				0						AGGCCGTCGTGGAACTCCCAG	0.652		NaN											0	0	0	0.09836	0	33	55									
C2orf65	130951	broad.mit.edu	37	2	74842183	74842183	+	Silent	SNP	G	G	A			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr2:74842183G>A	uc002smy.2	-	3	451	c.334C>T	c.(334-336)CTG>TTG	p.L112L	C2orf65_uc010ysa.1_Silent_p.L112L|C2orf65_uc002smz.2_Silent_p.L112L	NM_138804	NP_620159	Q8TC57	CB065_HUMAN	hypothetical protein LOC130951	112					chromatin assembly|female gamete generation|RNA processing|spermatogenesis	integral to membrane				ovary(1)|pancreas(1)	2						GCCAGCCGCAGAGAAGCACCT	0.507		NaN											0	0	0	0.104719	0	32	87									
LYG2	254773	broad.mit.edu	37	2	99861855	99861855	+	Missense_Mutation	SNP	A	A	T			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr2:99861855A>T	uc002szw.1	-	4	364	c.251T>A	c.(250-252)ATC>AAC	p.I84N	MRPL30_uc002szl.1_Intron|LYG2_uc010fip.1_Missense_Mutation_p.I84N|LYG2_uc002szx.1_Missense_Mutation_p.I84N	NM_175735	NP_783862	Q86SG7	LYG2_HUMAN	lysozyme G-like 2 precursor	84					cell wall macromolecule catabolic process|peptidoglycan catabolic process	extracellular region	lysozyme activity			ovary(1)	1						GACTTCTTTGATCAGAGTCTG	0.483		NaN											0	0	0	0.146539	0	14	44									
WDR33	55339	broad.mit.edu	37	2	128477268	128477268	+	Missense_Mutation	SNP	C	C	A			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr2:128477268C>A	uc002tpg.1	-	16	2514	c.2331G>T	c.(2329-2331)ATG>ATT	p.M777I		NM_018383	NP_060853	Q9C0J8	WDR33_HUMAN	WD repeat domain 33 isoform 1	777					postreplication repair|spermatogenesis	collagen|nucleus	protein binding				0	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0695)		GATTCAATCCCATCAGAGGTC	0.602		NaN											1	0	0.00909568	0.009096	0.00916065	4	9									
TTN	7273	broad.mit.edu	37	2	179432361	179432361	+	Missense_Mutation	SNP	C	C	G			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr2:179432361C>G	uc010zfg.1	-	275	71018	c.70794G>C	c.(70792-70794)AAG>AAC	p.K23598N	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.K17293N|TTN_uc010zfi.1_Missense_Mutation_p.K17226N|TTN_uc010zfj.1_Missense_Mutation_p.K17101N	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	24525							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CAGCTGCATTCTTTGCAATGA	0.388		NaN											0	0	0	0.076483	0	16	44									
TTN	7273	broad.mit.edu	37	2	179497730	179497730	+	Silent	SNP	G	G	A			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr2:179497730G>A	uc010zfg.1	-	183	35648	c.35424C>T	c.(35422-35424)ATC>ATT	p.I11808I	TTN_uc010zfh.1_Silent_p.I5503I|TTN_uc010zfi.1_Silent_p.I5436I|TTN_uc010zfj.1_Silent_p.I5311I	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	12735							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AGTTATGAAGGATCAGAATAT	0.408		NaN											0	0	0	0.069288	0	20	19									
TRAK2	66008	broad.mit.edu	37	2	202264201	202264201	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr2:202264201C>T	uc002uyb.3	-	5	825	c.379G>A	c.(379-381)GAA>AAA	p.E127K	TRAK2_uc002uyc.2_Missense_Mutation_p.E127K	NM_015049	NP_055864	O60296	TRAK2_HUMAN	trafficking protein, kinesin binding 2	127						early endosome|plasma membrane	GABA receptor binding				0						GCAGCGAGTTCCAGATCACGA	0.413		NaN											0	0	0	0.0333	0	12	51									
COL4A4	1286	broad.mit.edu	37	2	227924258	227924258	+	Nonsense_Mutation	SNP	G	G	T			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr2:227924258G>T	uc010zlt.1	-	28	2900	c.2246C>A	c.(2245-2247)TCA>TAA	p.S749*		NM_000092	NP_000083	P53420	CO4A4_HUMAN	alpha 4 type IV collagen precursor	749	Triple-helical region.				axon guidance|glomerular basement membrane development	basal lamina|collagen type IV	extracellular matrix structural constituent|protein binding			ovary(5)|central_nervous_system(3)|pancreas(1)|breast(1)|skin(1)	11		Renal(207;0.00844)|all_lung(227;0.0187)|Lung NSC(271;0.0879)|all_hematologic(139;0.21)|Esophageal squamous(248;0.242)		Epithelial(121;6.7e-11)|all cancers(144;5.39e-08)|Lung(261;0.0132)|LUSC - Lung squamous cell carcinoma(224;0.0181)		CACTCCTGGTGAGCCGGGAGG	0.552		NaN											1	0	2.37509e-13	0.055883	2.5564e-13	18	55									
TRIP12	9320	broad.mit.edu	37	2	230723895	230723895	+	Nonsense_Mutation	SNP	G	G	C			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr2:230723895G>C	uc002vpw.1	-	3	603	c.494C>G	c.(493-495)TCA>TGA	p.S165*	TRIP12_uc002vpx.1_Nonsense_Mutation_p.S207*|TRIP12_uc002vpy.1_Intron|TRIP12_uc010zlz.1_RNA|TRIP12_uc010fxh.1_Nonsense_Mutation_p.S165*	NM_004238	NP_004229	Q14669	TRIPC_HUMAN	thyroid hormone receptor interactor 12	165					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	proteasome complex	thyroid hormone receptor binding|ubiquitin-protein ligase activity			ovary(4)|lung(2)|breast(1)|central_nervous_system(1)|skin(1)	9		Renal(207;0.025)|all_hematologic(139;0.122)|all_lung(227;0.126)|Acute lymphoblastic leukemia(138;0.164)		Epithelial(121;4.76e-13)|all cancers(144;4.34e-10)|LUSC - Lung squamous cell carcinoma(224;0.00864)|Lung(119;0.0116)		TGCACCAGTTGATTCAGACCC	0.502		NaN											0	0	0	0.055883	0	20	11									
SP100	6672	broad.mit.edu	37	2	231308897	231308897	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr2:231308897C>T	uc002vqt.2	+	4	416	c.275C>T	c.(274-276)TCT>TTT	p.S92F	SP100_uc002vqs.2_Missense_Mutation_p.S92F|SP100_uc002vqu.1_Missense_Mutation_p.S92F|SP100_uc010zmb.1_Missense_Mutation_p.S92F|SP100_uc002vqq.1_Missense_Mutation_p.S92F|SP100_uc002vqr.1_Missense_Mutation_p.S67F|SP100_uc010zmc.1_Missense_Mutation_p.S67F|SP100_uc002vqv.1_Missense_Mutation_p.S56F	NM_003113	NP_003104	P23497	SP100_HUMAN	nuclear antigen Sp100 isoform 2	92	HSR.				DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|interspecies interaction between organisms|negative regulation of cellular component movement|negative regulation of DNA binding|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|negative regulation of transcription, DNA-dependent|negative regulation of viral transcription|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|response to cytokine stimulus|response to retinoic acid|response to type I interferon	cytoplasm|nuclear periphery|nucleolus|PML body	chromo shadow domain binding|DNA binding|identical protein binding|kinase binding|protein homodimerization activity|transcription coactivator activity|transcription corepressor activity|transcription factor binding			ovary(4)|central_nervous_system(1)	5		Renal(207;0.0112)|all_lung(227;0.0335)|all_hematologic(139;0.0749)|Lung NSC(271;0.142)|Acute lymphoblastic leukemia(138;0.167)		Epithelial(121;1.13e-12)|all cancers(144;2.71e-10)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.00942)		TTTAAGGATTCTCAAGATTCT	0.363		NaN											0	0	0	0.146539	0	14	24									
KIF1A	547	broad.mit.edu	37	2	241710491	241710491	+	Nonsense_Mutation	SNP	G	G	C			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr2:241710491G>C	uc002vzy.2	-	14	1357	c.1211C>G	c.(1210-1212)TCA>TGA	p.S404*	KIF1A_uc010fzk.2_Nonsense_Mutation_p.S413*|KIF1A_uc002vzz.1_Nonsense_Mutation_p.S413*	NM_004321	NP_004312	Q12756	KIF1A_HUMAN	axonal transport of synaptic vesicles	404					anterograde axon cargo transport	cytoplasm|microtubule|nucleus	ATP binding|microtubule motor activity			lung(1)	1		all_epithelial(40;1.35e-15)|Breast(86;2.14e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0295)|all_neural(83;0.0459)|Lung NSC(271;0.0942)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;6.12e-30)|all cancers(36;3.46e-27)|OV - Ovarian serous cystadenocarcinoma(60;1.38e-14)|Kidney(56;5e-09)|KIRC - Kidney renal clear cell carcinoma(57;5e-08)|BRCA - Breast invasive adenocarcinoma(100;5.87e-06)|Lung(119;0.00209)|LUSC - Lung squamous cell carcinoma(224;0.00902)|Colorectal(34;0.0282)|COAD - Colon adenocarcinoma(134;0.176)		GAGCGAGGATGAGGGGCTCAT	0.617		NaN											0	0	0	0.132662	0	13	40									
NEU4	129807	broad.mit.edu	37	2	242757402	242757402	+	Silent	SNP	C	C	T			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr2:242757402C>T	uc010fzr.2	+	4	569	c.483C>T	c.(481-483)CCC>CCT	p.P161P	NEU4_uc002wcl.2_RNA|NEU4_uc002wcm.2_Silent_p.P161P|NEU4_uc002wcn.1_Silent_p.P173P|NEU4_uc002wco.1_Silent_p.P161P|NEU4_uc002wcp.1_Silent_p.P173P	NM_080741	NP_542779	Q8WWR8	NEUR4_HUMAN	sialidase 4	161						lysosomal lumen|organelle inner membrane	exo-alpha-sialidase activity|protein binding				0		all_cancers(19;1.09e-40)|all_epithelial(40;2.03e-18)|Breast(86;1.53e-05)|all_lung(227;0.00338)|Renal(207;0.00502)|Ovarian(221;0.00716)|Lung NSC(271;0.012)|Esophageal squamous(248;0.129)|Melanoma(123;0.144)|all_hematologic(139;0.158)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;3.84e-33)|all cancers(36;8.08e-31)|OV - Ovarian serous cystadenocarcinoma(60;7.41e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;1.63e-06)|Lung(119;0.000152)|LUSC - Lung squamous cell carcinoma(224;0.00154)|Colorectal(34;0.0129)|COAD - Colon adenocarcinoma(134;0.0825)		CTGTGGGTCCCGGCCACGGCG	0.706		NaN											0	0	0	0.069234	0	9	6									
JAG1	182	broad.mit.edu	37	20	10621880	10621880	+	Missense_Mutation	SNP	C	C	G			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr20:10621880C>G	uc002wnw.2	-	24	3445	c.2929G>C	c.(2929-2931)GAG>CAG	p.E977Q		NM_000214	NP_000205	P78504	JAG1_HUMAN	jagged 1 precursor	977	Extracellular (Potential).				angiogenesis|cell communication|cell fate determination|endothelial cell differentiation|hemopoiesis|keratinocyte differentiation|myoblast differentiation|Notch receptor processing|Notch signaling pathway|regulation of cell migration|regulation of cell proliferation	extracellular region|integral to plasma membrane	calcium ion binding|growth factor activity|Notch binding|structural molecule activity			lung(3)|ovary(2)|central_nervous_system(2)|breast(1)|pancreas(1)	9						CAAATGTGCTCCGTAGTAAGA	0.408		NaN							Alagille_Syndrome				0	0	0	0.014758	0	4	62									
FOXA2	3170	broad.mit.edu	37	20	22563496	22563496	+	Silent	SNP	G	G	T			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr20:22563496G>T	uc002wsn.2	-	3	556	c.366C>A	c.(364-366)GGC>GGA	p.G122G	FOXA2_uc002wsm.2_Silent_p.G128G	NM_153675	NP_710141	Q9Y261	FOXA2_HUMAN	forkhead box A2 isoform 2	122					cell differentiation in hindbrain|central nervous system myelin formation|chromatin modification|dorsal/ventral neural tube patterning|ectoderm formation|endocrine pancreas development|endoderm development|epithelial tube branching involved in lung morphogenesis|in utero embryonic development|lung epithelial cell differentiation|negative regulation of neuron differentiation|neuron fate specification|oligodendrocyte cell fate commitment|positive regulation of embryonic development|positive regulation of gastrulation|positive regulation of neuron differentiation|primitive streak formation|regulation of blood coagulation|regulation of sequence-specific DNA binding transcription factor activity|response to interleukin-6	cytoplasm|transcription factor complex	DNA bending activity|double-stranded DNA binding|protein domain specific binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			ovary(2)|kidney(1)|central_nervous_system(1)	4	Lung NSC(19;0.188)					GGGCCAGGCCGCCCATGGCCC	0.756		NaN											1	0	0.00024832	0.009096	0.00025557	4	19									
CHD6	84181	broad.mit.edu	37	20	40050336	40050336	+	Missense_Mutation	SNP	G	G	C			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr20:40050336G>C	uc002xka.1	-	31	5117	c.4939C>G	c.(4939-4941)CAA>GAA	p.Q1647E		NM_032221	NP_115597	Q8TD26	CHD6_HUMAN	chromodomain helicase DNA binding protein 6	1647					chromatin remodeling|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding			ovary(6)|skin(5)|lung(2)|central_nervous_system(1)	14		Myeloproliferative disorder(115;0.00425)				CTACTCATTTGAGAATATGTA	0.423		NaN											0	0	0	0.105934	0	12	26									
SEMG1	6406	broad.mit.edu	37	20	43837052	43837052	+	Missense_Mutation	SNP	C	C	A			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr20:43837052C>A	uc002xni.2	+	2	1171	c.1114C>A	c.(1114-1116)CGC>AGC	p.R372S	SEMG1_uc002xnj.2_Missense_Mutation_p.R312S|SEMG2_uc010ggz.2_Intron|SEMG1_uc002xnh.2_Intron	NM_003007	NP_002998	P04279	SEMG1_HUMAN	semenogelin I preproprotein	372	58 AA repeat 2.				insemination|sexual reproduction	extracellular space|stored secretory granule	structural molecule activity			skin(2)	2		Myeloproliferative disorder(115;0.0122)				TGTATCCCAACGCAGTATTTA	0.418		NaN											1	0	0.00024832	0.009096	0.00025557	4	58									
BTG3	10950	broad.mit.edu	37	21	18977218	18977218	+	Nonsense_Mutation	SNP	C	C	A			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr21:18977218C>A	uc002ykk.2	-	3	531	c.271G>T	c.(271-273)GAG>TAG	p.E91*	BTG3_uc002ykl.2_Nonsense_Mutation_p.E91*	NM_006806	NP_006797	Q14201	BTG3_HUMAN	B-cell translocation gene 3 isoform b	91					negative regulation of cell proliferation|negative regulation of mitotic cell cycle	cytoplasm					0				Epithelial(23;0.000283)|all cancers(11;0.0012)|Lung(58;0.0191)|OV - Ovarian serous cystadenocarcinoma(11;0.0206)|COAD - Colon adenocarcinoma(22;0.0315)|LUSC - Lung squamous cell carcinoma(23;0.0703)|Colorectal(24;0.0971)		AGAGTGAGCTCCTTTGGCAAG	0.448		NaN											1	0	2.39187e-15	0.049695	2.59426e-15	19	26									
GABPA	2551	broad.mit.edu	37	21	27130452	27130452	+	Missense_Mutation	SNP	G	G	T			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr21:27130452G>T	uc002ylx.3	+	6	1212	c.685G>T	c.(685-687)GAT>TAT	p.D229Y	GABPA_uc002yly.3_Missense_Mutation_p.D229Y	NM_002040	NP_002031	Q06546	GABPA_HUMAN	GA binding protein transcription factor, alpha	229	PNT.				positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleus	protein heterodimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription regulatory region DNA binding			ovary(1)|central_nervous_system(1)	2						CAACCAAGAAGATTTTTTTCA	0.398		NaN											1	0	8.10497e-08	0.055883	8.49666e-08	16	42									
AGPAT3	56894	broad.mit.edu	37	21	45387862	45387862	+	Missense_Mutation	SNP	G	G	C			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr21:45387862G>C	uc002zdv.2	+	4	436	c.214G>C	c.(214-216)GAG>CAG	p.E72Q	AGPAT3_uc002zdw.2_Missense_Mutation_p.E72Q|AGPAT3_uc002zdx.2_Missense_Mutation_p.E159Q|AGPAT3_uc002zdy.2_Missense_Mutation_p.E10Q	NM_020132	NP_064517	Q9NRZ7	PLCC_HUMAN	1-acylglycerol-3-phosphate O-acyltransferase 3	72	Cytoplasmic (Potential).				phospholipid biosynthetic process	endoplasmic reticulum membrane|integral to membrane|plasma membrane	1-acylglycerol-3-phosphate O-acyltransferase activity				0				STAD - Stomach adenocarcinoma(101;0.18)|Colorectal(79;0.24)		GTCCTGCACGGAGTGTACACT	0.612		NaN											0	0	0	0.047766	0	8	26									
KRTAP10-3	386682	broad.mit.edu	37	21	45978005	45978005	+	Silent	SNP	G	G	C			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr21:45978005G>C	uc002zfj.1	-	1	639	c.594C>G	c.(592-594)CTC>CTG	p.L198L	C21orf29_uc002zfe.1_Intron|C21orf29_uc010gpv.1_Intron	NM_198696	NP_941969	P60369	KR103_HUMAN	keratin associated protein 10-3	198	18 X 5 AA repeats of C-C-X(3).					keratin filament				skin(1)	1						TGGGGCGGCAGAGGAGGGACA	0.692		NaN											0	0	0	0.02938	0	7	32									
MED15	51586	broad.mit.edu	37	22	20909408	20909408	+	Missense_Mutation	SNP	G	G	T			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr22:20909408G>T	uc002zsp.2	+	5	504	c.424G>T	c.(424-426)GCT>TCT	p.A142S	MED15_uc002zsn.1_Missense_Mutation_p.A61S|MED15_uc002zso.2_Intron|MED15_uc002zsq.2_Missense_Mutation_p.A142S|MED15_uc010gso.2_Missense_Mutation_p.A142S|MED15_uc002zsr.2_Missense_Mutation_p.A116S|MED15_uc011ahs.1_Missense_Mutation_p.A116S|MED15_uc011aht.1_Missense_Mutation_p.A116S|MED15_uc002zss.2_Missense_Mutation_p.A61S	NM_001003891	NP_001003891	Q96RN5	MED15_HUMAN	mediator complex subunit 15 isoform a	142					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|mediator complex	protein binding			skin(1)	1	all_cancers(11;2.07e-24)|Melanoma(16;0.000465)|Ovarian(15;0.00167)|Colorectal(54;0.0221)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.00102)|Lung(15;0.0173)|Epithelial(17;0.209)			TCACAGCATGGCTGTCGTGTC	0.567		NaN											1	0	2.56e-06	0.009096	2.65412e-06	3	6									
SLC7A4	6545	broad.mit.edu	37	22	21384120	21384120	+	Silent	SNP	C	C	T			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr22:21384120C>T	uc002zud.2	-	3	1571	c.1503G>A	c.(1501-1503)TCG>TCA	p.S501S	SLC7A4_uc002zue.2_Silent_p.S501S	NM_004173	NP_004164	O43246	CTR4_HUMAN	solute carrier family 7 (cationic amino acid	501					cellular amino acid metabolic process	integral to membrane	basic amino acid transmembrane transporter activity			ovary(1)|lung(1)	2	all_cancers(11;2.85e-22)|Lung NSC(8;4.21e-14)|all_lung(8;6.08e-13)|Melanoma(16;0.000465)|Ovarian(15;0.0028)|Colorectal(54;0.0968)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.000204)|Lung(15;0.00494)|Epithelial(17;0.195)		L-Arginine(DB00125)|L-Lysine(DB00123)|L-Ornithine(DB00129)	GGTGCAGGGTCGAGTTCCCAA	0.582		NaN											0	0	0	0.021553	0	6	25									
HPS4	89781	broad.mit.edu	37	22	26860275	26860275	+	Missense_Mutation	SNP	C	C	G			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr22:26860275C>G	uc003acl.2	-	11	1980	c.1321G>C	c.(1321-1323)GAG>CAG	p.E441Q	HPS4_uc003aci.2_Missense_Mutation_p.E436Q|HPS4_uc003acj.2_Missense_Mutation_p.E305Q|HPS4_uc003ack.2_Missense_Mutation_p.E232Q|HPS4_uc003acn.2_Missense_Mutation_p.E287Q|HPS4_uc010gvd.1_Missense_Mutation_p.E459Q|HPS4_uc003ach.2_Missense_Mutation_p.E176Q	NM_022081	NP_071364	Q9NQG7	HPS4_HUMAN	light ear protein isoform a	441					lysosome organization|positive regulation of eye pigmentation|protein stabilization|protein targeting	lysosome|melanosome|membrane fraction|platelet dense granule	protein homodimerization activity				0						TCGAGCTGCTCTTGGGCTCCA	0.632		NaN							Hermansky-Pudlak_syndrome				0	0	0	0.144211	0	27	79									
MORC2	22880	broad.mit.edu	37	22	31332626	31332626	+	Missense_Mutation	SNP	C	C	G			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr22:31332626C>G	uc003aje.1	-	18	2787	c.1423G>C	c.(1423-1425)GAG>CAG	p.E475Q		NM_014941	NP_055756	Q9Y6X9	MORC2_HUMAN	MORC family CW-type zinc finger 2	537	CW-type.						ATP binding|zinc ion binding			ovary(1)|pancreas(1)	2						TCAGAAGCCTCACACCTGTAG	0.493		NaN											0	0	0	0.139131	0	40	44									
CELSR1	9620	broad.mit.edu	37	22	46787591	46787591	+	Silent	SNP	G	G	A			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr22:46787591G>A	uc003bhw.1	-	15	6087	c.6087C>T	c.(6085-6087)ATC>ATT	p.I2029I	CELSR1_uc011arc.1_Silent_p.I350I	NM_014246	NP_055061	Q9NYQ6	CELR1_HUMAN	cadherin EGF LAG seven-pass G-type receptor 1	2029	Extracellular (Potential).|Laminin EGF-like.				central nervous system development|homophilic cell adhesion|neural tube closure|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein dimerization activity			lung(4)|breast(4)|pancreas(2)|skin(1)	11		Ovarian(80;0.00142)|Breast(42;0.00296)|all_neural(38;0.0416)|Colorectal(5;0.0766)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00643)|BRCA - Breast invasive adenocarcinoma(115;0.171)		ACTGGCGGCCGATGACGCCGG	0.682		NaN											0	0	0	0.021553	0	4	21									
TUBGCP6	85378	broad.mit.edu	37	22	50659293	50659293	+	Silent	SNP	G	G	A			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr22:50659293G>A	uc003bkb.1	-	16	4007	c.3495C>T	c.(3493-3495)TCC>TCT	p.S1165S	TUBGCP6_uc003bka.1_Silent_p.S252S|TUBGCP6_uc010har.1_Silent_p.S1157S|TUBGCP6_uc010has.1_RNA	NM_020461	NP_065194	Q96RT7	GCP6_HUMAN	tubulin, gamma complex associated protein 6	1165	9 X 27 AA tandem repeats.|6.				G2/M transition of mitotic cell cycle|microtubule nucleation	centrosome|cytosol|gamma-tubulin ring complex|microtubule|spindle pole	microtubule binding			ovary(2)|central_nervous_system(2)	4		all_cancers(38;5.79e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		LUAD - Lung adenocarcinoma(64;0.109)|BRCA - Breast invasive adenocarcinoma(115;0.21)		TGCTGGCATCGGACACGTGTC	0.637		NaN											0	0	0	0.021553	0	4	103									
TGFBR2	7048	broad.mit.edu	37	3	30713543	30713543	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr3:30713543G>A	uc003ceo.2	+	4	1250	c.868G>A	c.(868-870)GAG>AAG	p.E290K	TGFBR2_uc003cen.2_Missense_Mutation_p.E315K	NM_003242	NP_003233	P37173	TGFR2_HUMAN	transforming growth factor, beta receptor II	290	Protein kinase.|Cytoplasmic (Potential).				activation of protein kinase activity|brain development|embryonic cranial skeleton morphogenesis|embryonic hemopoiesis|heart development|myeloid dendritic cell differentiation|palate development|pathway-restricted SMAD protein phosphorylation|patterning of blood vessels|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of B cell tolerance induction|positive regulation of mesenchymal cell proliferation|positive regulation of NK T cell differentiation|positive regulation of reactive oxygen species metabolic process|positive regulation of T cell tolerance induction|positive regulation of tolerance induction to self antigen|response to cholesterol|response to drug|transforming growth factor beta receptor signaling pathway|transforming growth factor beta receptor signaling pathway|vasculogenesis	caveola|external side of plasma membrane	ATP binding|glycosaminoglycan binding|metal ion binding|protein binding|receptor signaling protein serine/threonine kinase activity|SMAD binding|transforming growth factor beta binding|transforming growth factor beta receptor activity, type II|type I transforming growth factor beta receptor binding|type I transforming growth factor beta receptor binding|type III transforming growth factor beta receptor binding			pancreas(9)|large_intestine(6)|stomach(4)|lung(3)|ovary(3)|central_nervous_system(1)	26						TTGGAAGACAGAGAAGGACAT	0.483		NaN											0	0	0	0.139131	0	61	15									
ULK4	54986	broad.mit.edu	37	3	41746766	41746766	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr3:41746766G>A	uc003ckv.3	-	26	2867	c.2666C>T	c.(2665-2667)ACG>ATG	p.T889M		NM_017886	NP_060356	Q96C45	ULK4_HUMAN	unc-51-like kinase 4	889							ATP binding|protein serine/threonine kinase activity				0				KIRC - Kidney renal clear cell carcinoma(284;0.214)		ATCTATGTTCGTTTCTCCTGA	0.294		NaN											0	0	0	0.139131	0	40	10									
LRRC2	79442	broad.mit.edu	37	3	46592976	46592976	+	Missense_Mutation	SNP	C	C	G			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr3:46592976C>G	uc010hji.2	-	2	470	c.106G>C	c.(106-108)GAG>CAG	p.E36Q	LRRC2_uc003cpu.3_Missense_Mutation_p.E36Q	NM_024512	NP_078788	Q9BYS8	LRRC2_HUMAN	leucine rich repeat containing 2	36										ovary(1)	1		Ovarian(412;0.0563)		OV - Ovarian serous cystadenocarcinoma(275;6.37e-05)|BRCA - Breast invasive adenocarcinoma(193;0.00133)|KIRC - Kidney renal clear cell carcinoma(197;0.0214)|Kidney(197;0.0254)		GCGCTCTTCTCAAGCCTTTCC	0.468		NaN											0	0	0	0.139131	0	54	23									
ARIH2	10425	broad.mit.edu	37	3	49012253	49012253	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr3:49012253C>T	uc003cvb.2	+	10	1204	c.892C>T	c.(892-894)CCC>TCC	p.P298S	ARIH2_uc003cvc.2_Missense_Mutation_p.P298S|ARIH2_uc003cvf.2_Missense_Mutation_p.P216S|ARIH2_uc010hkl.2_Missense_Mutation_p.P298S	NM_006321	NP_006312	O95376	ARI2_HUMAN	ariadne homolog 2	298	RING-type 2.				developmental cell growth|hemopoietic stem cell proliferation|protein K48-linked ubiquitination|protein K63-linked ubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	nucleic acid binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding	p.P298P(1)		ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;9.42e-05)|Kidney(197;0.00258)|KIRC - Kidney renal clear cell carcinoma(197;0.00269)		TCCTCAGTGTCCCAAGTGCAA	0.498		NaN											0	0	0	0.139131	0	42	8									
CBLB	868	broad.mit.edu	37	3	105377858	105377858	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr3:105377858C>T	uc003dwc.2	-	19	3227	c.2905G>A	c.(2905-2907)GAA>AAA	p.E969K	CBLB_uc003dwa.2_Missense_Mutation_p.E184K|CBLB_uc011bhi.1_Missense_Mutation_p.E947K	NM_170662	NP_733762	Q13191	CBLB_HUMAN	Cas-Br-M (murine) ecotropic retroviral	969	UBA.				cell surface receptor linked signaling pathway|NLS-bearing substrate import into nucleus	cytoplasm|nucleus	calcium ion binding|ligase activity|signal transducer activity|zinc ion binding			lung(4)|ovary(3)|breast(1)|skin(1)	9						AAGGCAAATTCTCGGAGGATG	0.468		NaN	Mis S		AML								0	0	0	0.125774	0	30	45									
VEPH1	79674	broad.mit.edu	37	3	157082155	157082155	+	Missense_Mutation	SNP	G	G	C			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr3:157082155G>C	uc003fbj.1	-	8	1591	c.1274C>G	c.(1273-1275)TCT>TGT	p.S425C	VEPH1_uc003fbk.1_Missense_Mutation_p.S425C|VEPH1_uc010hvu.1_Missense_Mutation_p.S425C	NM_024621	NP_078897	Q14D04	MELT_HUMAN	ventricular zone expressed PH domain homolog 1	425						plasma membrane				breast(3)|ovary(1)|lung(1)	5			Lung(72;0.0272)|LUSC - Lung squamous cell carcinoma(72;0.0461)			TCTTCTGATAGAGCCAGGGGT	0.348		NaN											0	0	0	0.080935	0	10	42									
PIK3CA	5290	broad.mit.edu	37	3	178922324	178922324	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr3:178922324G>A	uc003fjk.2	+	6	1250	c.1093G>A	c.(1093-1095)GAA>AAA	p.E365K		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	365	C2 PI3K-type.				epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.E365K(2)		breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			CCATGGAGGAGAACCCTTATG	0.343		57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			0	0	0	0.139131	0	58	62									
HTT	3064	broad.mit.edu	37	4	3142363	3142363	+	Missense_Mutation	SNP	C	C	G			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr4:3142363C>G	uc011bvq.1	+	23	3076	c.2931C>G	c.(2929-2931)TTC>TTG	p.F977L		NM_002111	NP_002102	P42858	HD_HUMAN	huntingtin	975					establishment of mitotic spindle orientation|Golgi organization|retrograde vesicle-mediated transport, Golgi to ER|vesicle transport along microtubule	autophagic vacuole|axon|cytoplasmic vesicle membrane|cytosol|dendrite|endoplasmic reticulum|Golgi apparatus|late endosome|membrane fraction|nucleus|protein complex	beta-tubulin binding|dynactin binding|dynein intermediate chain binding|p53 binding|transcription factor binding			skin(2)|ovary(1)|lung(1)	4		all_epithelial(65;0.18)		UCEC - Uterine corpus endometrioid carcinoma (64;0.187)		CATCTCATTTCTCCGTCAGCA	0.473		NaN											0	0	0	0.115264	0	3	62									
WFS1	7466	broad.mit.edu	37	4	6302887	6302887	+	Silent	SNP	G	G	A			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr4:6302887G>A	uc003giy.2	+	8	1531	c.1365G>A	c.(1363-1365)ACG>ACA	p.T455T	WFS1_uc003gix.2_Silent_p.T455T|WFS1_uc003giz.2_Silent_p.T273T	NM_001145853	NP_001139325	O76024	WFS1_HUMAN	wolframin	455					endoplasmic reticulum calcium ion homeostasis|endoplasmic reticulum unfolded protein response|ER overload response|ER-associated protein catabolic process|glucose homeostasis|kidney development|negative regulation of neuron apoptosis|negative regulation of sequence-specific DNA binding transcription factor activity|polyubiquitinated misfolded protein transport|positive regulation of calcium ion transport|positive regulation of growth|positive regulation of protein ubiquitination|positive regulation of proteolysis|protein stabilization|renal water homeostasis|sensory perception of sound|visual perception	dendrite|integral to endoplasmic reticulum membrane	activating transcription factor binding|ATPase binding|transporter activity|ubiquitin protein ligase binding			central_nervous_system(2)	2				Colorectal(103;0.0512)		AGCCCTACACGCGCAGGGCCC	0.637		NaN											0	0	0	0.116897	0	22	55									
ZNF518B	85460	broad.mit.edu	37	4	10446215	10446215	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr4:10446215G>A	uc003gmn.2	-	3	2225	c.1738C>T	c.(1738-1740)CAC>TAC	p.H580Y		NM_053042	NP_444270	Q9C0D4	Z518B_HUMAN	zinc finger protein 518B	580					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)|upper_aerodigestive_tract(1)	4						ACTGCCTTGTGTTCCTCTGTC	0.393		NaN											0	0	0	0.064281	0	30	47									
N4BP2	55728	broad.mit.edu	37	4	40104376	40104376	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr4:40104376G>A	uc003guy.3	+	4	1249	c.911G>A	c.(910-912)GGT>GAT	p.G304D	N4BP2_uc010ifq.2_Missense_Mutation_p.G224D|N4BP2_uc010ifr.2_Missense_Mutation_p.G224D	NM_018177	NP_060647	Q86UW6	N4BP2_HUMAN	Nedd4 binding protein 2	304						cytoplasm	ATP binding|ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity|endonuclease activity|protein binding			lung(3)|breast(2)|kidney(2)|ovary(1)	8						GATTTACCAGGTACAGGTGGG	0.473		NaN											0	0	0	0.108266	0	22	51									
CNOT6L	246175	broad.mit.edu	37	4	78650191	78650191	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr4:78650191C>T	uc011ccd.1	-	10	1200	c.1069G>A	c.(1069-1071)GCA>ACA	p.A357T	CNOT6L_uc003hks.2_Missense_Mutation_p.A357T|CNOT6L_uc003hkt.1_Missense_Mutation_p.A200T	NM_144571	NP_653172	Q96LI5	CNO6L_HUMAN	CCR4-NOT transcription complex, subunit 6-like	357					nuclear-transcribed mRNA poly(A) tail shortening	cytosol	exonuclease activity|protein binding	p.V357I(1)		large_intestine(1)	1						TGGGCATTTGCCACTATAAGC	0.388		NaN											0	0	0	0.050027	0	23	61									
CNOT6L	246175	broad.mit.edu	37	4	78650194	78650194	+	Missense_Mutation	SNP	C	C	G			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr4:78650194C>G	uc011ccd.1	-	10	1197	c.1066G>C	c.(1066-1068)GTG>CTG	p.V356L	CNOT6L_uc003hks.2_Missense_Mutation_p.V356L|CNOT6L_uc003hkt.1_Missense_Mutation_p.V199L	NM_144571	NP_653172	Q96LI5	CNO6L_HUMAN	CCR4-NOT transcription complex, subunit 6-like	356					nuclear-transcribed mRNA poly(A) tail shortening	cytosol	exonuclease activity|protein binding			large_intestine(1)	1						GCATTTGCCACTATAAGCAGC	0.388		NaN											0	0	0	0.045705	0	22	60									
MRPL1	65008	broad.mit.edu	37	4	78815330	78815330	+	Missense_Mutation	SNP	C	C	G			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr4:78815330C>G	uc003hku.2	+	6	794	c.596C>G	c.(595-597)GCT>GGT	p.A199G	MRPL1_uc010iji.1_Missense_Mutation_p.A122G	NM_020236	NP_064621	Q9BYD6	RM01_HUMAN	mitochondrial ribosomal protein L1 precursor	199							RNA binding				0						TTTTACGTAGCTGTTCCAGAA	0.308		NaN											0	0	0	0.139131	0	37	75									
AIMP1	9255	broad.mit.edu	37	4	107268795	107268795	+	Silent	SNP	G	G	A			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr4:107268795G>A	uc011cfg.1	+	7	937	c.885G>A	c.(883-885)GTG>GTA	p.V295V	AIMP1_uc003hyg.2_Silent_p.V295V|AIMP1_uc003hyh.2_Silent_p.V319V	NM_001142415	NP_001135887	Q12904	AIMP1_HUMAN	small inducible cytokine subfamily E, member 1	295					angiogenesis|apoptosis|cell adhesion|cell-cell signaling|chemotaxis|glucose metabolic process|inflammatory response|leukocyte migration|negative regulation of endothelial cell proliferation|signal transduction|tRNA aminoacylation for protein translation	aminoacyl-tRNA synthetase multienzyme complex|cytosol|endoplasmic reticulum|extracellular space|Golgi apparatus|nucleus|transport vesicle	cell surface binding|cytokine activity|protein homodimerization activity|tRNA binding				0						CCTTTGAGGTGAAAGGGAAGG	0.413		NaN											0	0	0	0.021553	0	4	44									
KIAA1109	84162	broad.mit.edu	37	4	123161005	123161005	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr4:123161005G>A	uc003ieh.2	+	27	4213	c.4168G>A	c.(4168-4170)GAT>AAT	p.D1390N	KIAA1109_uc003iei.1_Missense_Mutation_p.D1143N|KIAA1109_uc010ins.1_Missense_Mutation_p.D733N|KIAA1109_uc003iek.2_Missense_Mutation_p.D9N	NM_015312	NP_056127	Q2LD37	K1109_HUMAN	fragile site-associated protein	1390					regulation of cell growth|regulation of epithelial cell differentiation	integral to membrane|nucleus				ovary(8)|skin(2)|pancreas(1)|central_nervous_system(1)	12						GTCAATGGCTGATAGTGAAGC	0.418		NaN											0	0	0	0.069288	0	19	33									
NPY2R	4887	broad.mit.edu	37	4	156135697	156135697	+	Silent	SNP	C	C	T			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr4:156135697C>T	uc003ioq.2	+	2	1101	c.606C>T	c.(604-606)GCC>GCT	p.A202A	NPY2R_uc003ior.2_Silent_p.A202A	NM_000910	NP_000901	P49146	NPY2R_HUMAN	neuropeptide Y receptor Y2	202	Extracellular (Potential).			A -> P (in Ref. 4; AAB07760).	cardiac left ventricle morphogenesis|inhibition of adenylate cyclase activity by G-protein signaling pathway|locomotory behavior|outflow tract morphogenesis	integral to plasma membrane	calcium channel regulator activity			lung(2)|skin(1)	3	all_hematologic(180;0.24)	Renal(120;0.0854)				AGATTGTGGCCTGTACTGAAA	0.507		NaN											0	0	0	0.058154	0	8	129									
ZFP42	132625	broad.mit.edu	37	4	188924685	188924685	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr4:188924685G>A	uc003izg.1	+	3	969	c.724G>A	c.(724-726)GAG>AAG	p.E242K	ZFP42_uc003izh.1_Missense_Mutation_p.E242K|ZFP42_uc003izi.1_Missense_Mutation_p.E242K	NM_174900	NP_777560	Q96MM3	ZFP42_HUMAN	zinc finger protein 42	242					female gonad development|male gonad development|meiosis	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|skin(1)	2		all_cancers(14;6.2e-52)|all_epithelial(14;7.36e-37)|all_lung(41;2.29e-15)|Lung NSC(41;6.7e-15)|Breast(6;1.53e-05)|Melanoma(20;3.01e-05)|Hepatocellular(41;0.00335)|all_hematologic(60;0.014)|Renal(120;0.0183)|Prostate(90;0.0421)|Colorectal(36;0.227)		OV - Ovarian serous cystadenocarcinoma(60;1.54e-11)|BRCA - Breast invasive adenocarcinoma(30;4.21e-06)|GBM - Glioblastoma multiforme(59;8.93e-05)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.157)		TCATACTGGAGAGAAGCCGTT	0.512		NaN											0	0	0	0.0333	0	15	27									
TRIM23	373	broad.mit.edu	37	5	64892995	64892995	+	Missense_Mutation	SNP	G	G	C			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr5:64892995G>C	uc003jty.2	-	8	1278	c.1192C>G	c.(1192-1194)CAC>GAC	p.H398D	TRIM23_uc003jtw.2_Missense_Mutation_p.H398D|TRIM23_uc003jtx.2_Missense_Mutation_p.H398D	NM_001656	NP_001647	P36406	TRI23_HUMAN	ADP-ribosylation factor domain protein 1 isoform	398	ARF-like.				interspecies interaction between organisms|small GTPase mediated signal transduction	Golgi membrane|lysosomal membrane	enzyme activator activity|GDP binding|GTP binding|GTPase activity|protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(3)|lung(1)	4		Lung NSC(167;3.24e-06)|Prostate(74;0.0138)|Breast(144;0.0433)|Ovarian(174;0.0545)|Colorectal(97;0.234)		Lung(70;0.00473)		GGTCCAATGTGAACTCGATTA	0.318		NaN											0	0	0	0.139131	0	49	57									
MSH3	4437	broad.mit.edu	37	5	79950579	79950579	+	Silent	SNP	C	C	T			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr5:79950579C>T	uc003kgz.2	+	1	286	c.33C>T	c.(31-33)CTC>CTT	p.L11L	DHFR_uc011ctl.1_5'UTR|DHFR_uc011ctm.1_5'UTR|DHFR_uc010jap.1_RNA|DHFR_uc003kgx.1_Silent_p.A59A|DHFR_uc003kgy.1_5'UTR	NM_002439	NP_002430	P20585	MSH3_HUMAN	mutS homolog 3	11					maintenance of DNA repeat elements|meiotic mismatch repair|negative regulation of DNA recombination|positive regulation of helicase activity|reciprocal meiotic recombination|somatic recombination of immunoglobulin gene segments	MutSbeta complex|nuclear chromosome	ATP binding|DNA-dependent ATPase activity|double-strand/single-strand DNA junction binding|enzyme binding|loop DNA binding|Y-form DNA binding			lung(2)|ovary(1)|breast(1)	4		Lung NSC(167;0.00479)|all_lung(232;0.00507)|Ovarian(174;0.0261)|Breast(144;0.244)		OV - Ovarian serous cystadenocarcinoma(54;2.38e-45)|Epithelial(54;1.58e-38)|all cancers(79;4.93e-33)		CGGGCGGCCTCGCTGCCTCCA	0.697		NaN						MMR					0	0	0	0.105934	0	9	25									
SNCAIP	9627	broad.mit.edu	37	5	121767723	121767723	+	Silent	SNP	G	G	A			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr5:121767723G>A	uc003ksw.1	+	6	1448	c.1242G>A	c.(1240-1242)CTG>CTA	p.L414L	SNCAIP_uc011cwl.1_5'UTR|SNCAIP_uc010jct.2_Silent_p.L414L|SNCAIP_uc003ksx.1_Silent_p.L461L|SNCAIP_uc003ksy.1_Silent_p.L48L|SNCAIP_uc003ksz.1_Silent_p.L48L|SNCAIP_uc010jcu.2_Intron|SNCAIP_uc011cwm.1_Silent_p.L48L|SNCAIP_uc003kta.1_Silent_p.L46L|SNCAIP_uc010jcv.1_RNA|SNCAIP_uc010jcw.1_Silent_p.L108L|SNCAIP_uc010jcx.1_Silent_p.L354L	NM_005460	NP_005451	Q9Y6H5	SNCAP_HUMAN	synuclein alpha interacting protein	414					cell death|dopamine metabolic process|regulation of inclusion body assembly|regulation of neurotransmitter secretion	cytoplasm|neuronal cell body|nucleolus|presynaptic membrane	ubiquitin protein ligase binding			ovary(1)|pancreas(1)	2		all_cancers(142;0.00787)|Prostate(80;0.0327)	KIRC - Kidney renal clear cell carcinoma(527;0.206)	OV - Ovarian serous cystadenocarcinoma(64;0.000625)|Epithelial(69;0.00216)|all cancers(49;0.0232)		TTGCAGAACTGAGTTGTTCTA	0.403		NaN											0	0	0	0.086207	0	30	17									
PCDHB8	56128	broad.mit.edu	37	5	140558309	140558309	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr5:140558309G>A	uc011dai.1	+	1	880	c.694G>A	c.(694-696)GAA>AAA	p.E232K	PCDHB16_uc003liv.2_5'Flank	NM_019120	NP_061993	Q9UN66	PCDB8_HUMAN	protocadherin beta 8 precursor	232	Cadherin 2.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			skin(4)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GGTCTACATTGAAGTTGTCGA	0.507		NaN											0	0	0	0.124865	0	35	29									
PCDHB11	56125	broad.mit.edu	37	5	140581588	140581588	+	Missense_Mutation	SNP	G	G	T			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr5:140581588G>T	uc003liy.2	+	1	2241	c.2241G>T	c.(2239-2241)CAG>CAT	p.Q747H	PCDHB11_uc011daj.1_Missense_Mutation_p.Q382H	NM_018931	NP_061754	Q9Y5F2	PCDBB_HUMAN	protocadherin beta 11 precursor	747	Cytoplasmic (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			skin(3)|ovary(2)|upper_aerodigestive_tract(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CCCTTTCCCAGAGCTACCAGT	0.582		NaN											1	0	2.18481e-45	0.139131	2.43524e-45	69	93									
PCDHGA10	56106	broad.mit.edu	37	5	140793016	140793016	+	Missense_Mutation	SNP	G	G	T			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr5:140793016G>T	uc003lkl.1	+	1	274	c.274G>T	c.(274-276)GGC>TGC	p.G92C	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc003lkh.1_Intron|PCDHGB6_uc003lkj.1_Intron|PCDHGA10_uc011day.1_Missense_Mutation_p.G92C	NM_018913	NP_061736	Q9Y5H3	PCDGA_HUMAN	protocadherin gamma subfamily A, 10 isoform 1	92	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GATCACCGCGGGCAGGATAGA	0.602		NaN											1	0	3.19467e-53	0.139131	3.57498e-53	62	58									
RBM27	54439	broad.mit.edu	37	5	145609388	145609388	+	Missense_Mutation	SNP	G	G	C			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr5:145609388G>C	uc003lnz.3	+	5	670	c.504G>C	c.(502-504)AAG>AAC	p.K168N	RBM27_uc003lny.2_Missense_Mutation_p.K168N	NM_018989	NP_061862	Q9P2N5	RBM27_HUMAN	RNA binding motif protein 27	168	Arg-rich.				mRNA processing	cytoplasm|nuclear speck	nucleotide binding|RNA binding|zinc ion binding			central_nervous_system(2)|pancreas(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			GCAggagtaagagtcggagta	0.428		NaN											0	0	0	0.124865	0	38	57									
SPINK5	11005	broad.mit.edu	37	5	147475436	147475436	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr5:147475436G>A	uc003lox.2	+	10	923	c.850G>A	c.(850-852)GAA>AAA	p.E284K	SPINK5_uc010jgq.1_RNA|SPINK5_uc010jgs.1_Missense_Mutation_p.E256K|SPINK5_uc010jgr.2_Missense_Mutation_p.E265K|SPINK5_uc003low.2_Missense_Mutation_p.E284K|SPINK5_uc003loy.2_Missense_Mutation_p.E284K	NM_006846	NP_006837	Q9NQ38	ISK5_HUMAN	serine peptidase inhibitor, Kazal type 5 isoform	284	Kazal-like 4.				anagen|epithelial cell differentiation|extracellular matrix organization|hair cell differentiation|negative regulation of angiogenesis|negative regulation of immune response|regulation of T cell differentiation	cell cortex|cytosol|endoplasmic reticulum membrane|extracellular region|lamellar body|perinuclear region of cytoplasm	serine-type endopeptidase inhibitor activity			skin(2)|ovary(1)|breast(1)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGGAAAAGCTGAAGAAAAAAC	0.373		NaN											0	0	0	0.124865	0	35	30									
DOCK2	1794	broad.mit.edu	37	5	169461533	169461533	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr5:169461533C>T	uc003maf.2	+	35	3678	c.3598C>T	c.(3598-3600)CGC>TGC	p.R1200C	DOCK2_uc011der.1_RNA|DOCK2_uc010jjm.2_Missense_Mutation_p.R692C	NM_004946	NP_004937	Q92608	DOCK2_HUMAN	dedicator of cytokinesis 2	1200	DHR-2.|Interaction with CRKL.				actin cytoskeleton organization|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|endomembrane system|membrane	electron carrier activity|GTP binding|GTPase binding|heme binding|Rac guanyl-nucleotide exchange factor activity|T cell receptor binding			ovary(5)|pancreas(2)	7	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			CAAAGACAACCGCATGAGCTG	0.592		NaN											0	0	0	0.083992	0	19	46									
KCNIP1	30820	broad.mit.edu	37	5	170145787	170145787	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr5:170145787G>A	uc003mas.2	+	3	649	c.120G>A	c.(118-120)ATG>ATA	p.M40I	KCNIP1_uc003map.2_Missense_Mutation_p.M38I|KCNIP1_uc003mat.2_Missense_Mutation_p.M29I|KCNIP1_uc010jjp.2_Missense_Mutation_p.M1I|KCNIP1_uc010jjq.2_Missense_Mutation_p.M29I	NM_001034837	NP_001030009	Q9NZI2	KCIP1_HUMAN	Kv channel interacting protein 1 isoform 1	40	EF-hand 1; degenerate.				detection of calcium ion|signal transduction|synaptic transmission	plasma membrane	potassium channel activity|voltage-gated ion channel activity			skin(2)	2	Renal(175;0.000159)|Lung NSC(126;0.0191)|all_lung(126;0.0297)	Medulloblastoma(196;0.0109)|all_neural(177;0.0177)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			AGCTGGAGATGACCATGGTTT	0.512		NaN											0	0	0	0.0333	0	13	23									
RGS14	10636	broad.mit.edu	37	5	176794807	176794807	+	Silent	SNP	C	C	T			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr5:176794807C>T	uc003mgf.2	+	7	902	c.720C>T	c.(718-720)CTC>CTT	p.L240L	RGS14_uc003mgg.1_Silent_p.L87L|RGS14_uc003mgh.2_Silent_p.L87L|RGS14_uc003mgi.2_5'UTR	NM_006480	NP_006471	O43566	RGS14_HUMAN	regulator of G-protein signalling 14	240					chromosome segregation|long-term memory|long-term synaptic potentiation|negative regulation of ERK1 and ERK2 cascade|negative regulation of MAP kinase activity|negative regulation of synaptic plasticity|nucleocytoplasmic transport|platelet-derived growth factor receptor signaling pathway|positive regulation of neurogenesis|regulation of DNA-dependent transcription in response to stress|regulation of G-protein coupled receptor protein signaling pathway|response to oxidative stress|spindle organization|visual learning|zygote asymmetric cell division	cell junction|centrosome|dendritic spine|microtubule|PML body|postsynaptic density|postsynaptic membrane|spindle pole	GDP-dissociation inhibitor activity|GTPase activator activity|microtubule binding|receptor signaling complex scaffold activity|receptor signaling protein activity			lung(1)	1	all_cancers(89;2.04e-05)|Renal(175;0.000269)|Lung NSC(126;0.000832)|all_lung(126;0.00152)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			GCCGCCCTCTCCGCAAGTCCT	0.652		NaN											0	0	0	0.11911	0	11	8									
DBN1	1627	broad.mit.edu	37	5	176895189	176895189	+	Missense_Mutation	SNP	C	C	G			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr5:176895189C>G	uc003mgy.2	-	3	347	c.175G>C	c.(175-177)GAG>CAG	p.E59Q	DBN1_uc003mgx.2_Missense_Mutation_p.E61Q|DBN1_uc010jkn.1_5'UTR|DBN1_uc003mgz.1_5'UTR	NM_004395	NP_004386	Q16643	DREB_HUMAN	drebrin 1 isoform a	59	ADF-H.				actin filament organization|regulation of dendrite development|regulation of neuronal synaptic plasticity	actomyosin|cytoplasm|dendrite	actin binding|profilin binding			breast(3)|ovary(1)|lung(1)|skin(1)	6	all_cancers(89;2.17e-05)|Renal(175;0.000269)|Lung NSC(126;0.0014)|all_lung(126;0.0025)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			TTCTGGTTCTCAAAGTGTCCC	0.552		NaN											0	0	0	0.139131	0	107	118									
DEK	7913	broad.mit.edu	37	6	18264194	18264194	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr6:18264194C>T	uc003ncr.1	-	2	218	c.25G>A	c.(25-27)GAG>AAG	p.E9K	DEK_uc011djf.1_Missense_Mutation_p.E9K|DEK_uc011djg.1_RNA	NM_003472	NP_003463	P35659	DEK_HUMAN	DEK oncogene isoform 1	9					chromatin modification|regulation of transcription from RNA polymerase II promoter|signal transduction|transcription from RNA polymerase II promoter|viral genome replication	nucleus	DNA binding|histone binding			kidney(1)	1	Ovarian(93;0.00769)|Breast(50;0.0495)	all_hematologic(90;0.053)	OV - Ovarian serous cystadenocarcinoma(7;0.00291)|all cancers(50;0.031)|Epithelial(50;0.0332)			CCCTCCCCCTCCGCAGCAGGG	0.562		NaN	T	NUP214	AML								0	0	0	0.076483	0	18	29									
PRSS16	10279	broad.mit.edu	37	6	27219016	27219016	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr6:27219016G>A	uc003nja.2	+	7	702	c.690G>A	c.(688-690)ATG>ATA	p.M230I	PRSS16_uc011dkt.1_Intron|PRSS16_uc003njb.2_Intron|PRSS16_uc010jqq.1_Intron|PRSS16_uc010jqr.1_Intron|PRSS16_uc003njc.1_Intron|PRSS16_uc003njd.2_5'Flank	NM_005865	NP_005856	Q9NQE7	TSSP_HUMAN	protease, serine, 16 precursor	230					protein catabolic process|proteolysis	cytoplasmic membrane-bounded vesicle	serine-type peptidase activity			ovary(2)|central_nervous_system(2)|skin(1)	5						GAAGCCTAATGAGCACCGCGA	0.672		NaN											0	0	0	0.104719	0	29	28									
HIST1H2BL	8340	broad.mit.edu	37	6	27775577	27775577	+	Silent	SNP	C	C	T			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr6:27775577C>T	uc003njl.2	-	1	133	c.108G>A	c.(106-108)GAG>GAA	p.E36E	HIST1H3H_uc003njm.2_5'Flank	NM_003519	NP_003510	Q99880	H2B1L_HUMAN	histone cluster 1, H2bl	36					nucleosome assembly	nucleosome|nucleus	DNA binding				0						CGGAGTAGCTCTCCTTGCGGC	0.587		NaN											0	0	0	0.139131	0	77	191									
OR14J1	442191	broad.mit.edu	37	6	29274779	29274779	+	Silent	SNP	C	C	T			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr6:29274779C>T	uc011dln.1	+	1	313	c.313C>T	c.(313-315)CTG>TTG	p.L105L		NM_030946	NP_112208	Q9UGF5	O14J1_HUMAN	olfactory receptor, family 5, subfamily U member	105	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						CTTCATAGCTCTGGCCTCATC	0.453		NaN											0	0	0	0.139131	0	47	43									
ZFP57	346171	broad.mit.edu	37	6	29640988	29640988	+	Silent	SNP	G	G	A			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr6:29640988G>A	uc011dlw.1	-	4	1051	c.900C>T	c.(898-900)ACC>ACT	p.T300T	ZFP57_uc003nnl.3_Silent_p.T280T	NM_001109809	NP_001103279	Q9NU63	ZFP57_HUMAN	zinc finger protein 57 homolog	216					DNA methylation involved in embryo development|regulation of gene expression by genetic imprinting|transcription, DNA-dependent		DNA binding|zinc ion binding			ovary(3)|skin(2)	5						ATTCAGCCTGGGTGCCTGGAA	0.557		NaN											0	0	0	0.139131	0	103	23									
MUC21	394263	broad.mit.edu	37	6	30954960	30954960	+	Silent	SNP	C	C	T	rs41288683		TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr6:30954960C>T	uc003nsh.2	+	2	1259	c.1008C>T	c.(1006-1008)AGC>AGT	p.S336S	MUC21_uc003nsi.1_RNA	NM_001010909	NP_001010909	Q5SSG8	MUC21_HUMAN	mucin 21 precursor	336	Ser-rich.|28 X 15 AA approximate tandem repeats.|21.|Extracellular (Potential).					integral to membrane|plasma membrane				ovary(1)|skin(1)	2						CTGAGTCCAGCACGACCTCCA	0.627		NaN											0	0	0	0.069288	0	6	169									
BACH2	60468	broad.mit.edu	37	6	90647890	90647890	+	Silent	SNP	C	C	T			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr6:90647890C>T	uc011eab.1	-	8	2825	c.2016G>A	c.(2014-2016)CAG>CAA	p.Q672Q	BACH2_uc003pnw.2_Silent_p.Q672Q	NM_021813	NP_068585	Q9BYV9	BACH2_HUMAN	BTB and CNC homology 1, basic leucine zipper	672						nucleus	protein dimerization activity|sequence-specific DNA binding			ovary(3)|pancreas(1)|lung(1)|skin(1)	6		all_cancers(76;7.37e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.0063)		BRCA - Breast invasive adenocarcinoma(108;0.0799)		ATTCTAAATTCTGAATACAGT	0.458		NaN											0	0	0	0.139131	0	58	19									
ZBTB24	9841	broad.mit.edu	37	6	109803198	109803198	+	Missense_Mutation	SNP	T	T	C			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr6:109803198T>C	uc003ptl.1	-	2	200	c.32A>G	c.(31-33)CAG>CGG	p.Q11R	ZBTB24_uc011ear.1_RNA|ZBTB24_uc010kds.1_Missense_Mutation_p.Q11R|ZBTB24_uc010kdt.1_RNA|ZBTB24_uc003ptm.2_Missense_Mutation_p.Q11R	NM_014797	NP_055612	O43167	ZBT24_HUMAN	zinc finger and BTB domain containing 24 isoform	11	BTB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3		all_cancers(87;0.000189)|Acute lymphoblastic leukemia(125;3.07e-08)|all_hematologic(75;3.33e-06)|all_epithelial(87;0.00686)|Lung SC(18;0.0743)|Colorectal(196;0.101)|all_lung(197;0.149)		Epithelial(106;0.0154)|all cancers(137;0.0216)|OV - Ovarian serous cystadenocarcinoma(136;0.0242)|BRCA - Breast invasive adenocarcinoma(108;0.059)		TACAACAAGCTGCCCAGAAGG	0.443		NaN											0	0	0	0.080422	0	29	13									
FYN	2534	broad.mit.edu	37	6	111983077	111983077	+	Silent	SNP	G	G	A			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr6:111983077G>A	uc003pvj.2	-	13	1819	c.1479C>T	c.(1477-1479)ATC>ATT	p.I493I	FYN_uc003pvi.2_Silent_p.I438I|FYN_uc003pvk.2_Silent_p.I493I|FYN_uc003pvh.2_Silent_p.I490I	NM_002037	NP_002028	P06241	FYN_HUMAN	protein-tyrosine kinase fyn isoform a	493	Protein kinase.				axon guidance|calcium ion transport|feeding behavior|interspecies interaction between organisms|intracellular protein kinase cascade|learning|leukocyte migration|platelet activation|regulation of defense response to virus by virus|T cell costimulation|T cell receptor signaling pathway|viral reproduction	cytosol|endosome|plasma membrane	ATP binding|glycoprotein binding|identical protein binding|metal ion binding|non-membrane spanning protein tyrosine kinase activity			lung(5)|central_nervous_system(1)|skin(1)	7		all_cancers(87;1.37e-05)|Acute lymphoblastic leukemia(125;2.15e-07)|all_hematologic(75;5.28e-06)|all_epithelial(87;0.00125)|Colorectal(196;0.0211)		all cancers(137;0.0451)|OV - Ovarian serous cystadenocarcinoma(136;0.0476)|Epithelial(106;0.102)	Dasatinib(DB01254)	CATGCAGAGAGATGGGGCAGT	0.567		NaN											0	0	0	0.139131	0	82	47									
SYNE1	23345	broad.mit.edu	37	6	152737694	152737694	+	Missense_Mutation	SNP	C	C	G			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr6:152737694C>G	uc010kiw.2	-	41	6480	c.5878G>C	c.(5878-5880)GAG>CAG	p.E1960Q	SYNE1_uc003qot.3_Missense_Mutation_p.E1967Q|SYNE1_uc003qou.3_Missense_Mutation_p.E1960Q|SYNE1_uc010kjb.1_Missense_Mutation_p.E1943Q	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	1960	Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		TGGATCCTCTCTACCTCTCCA	0.502		NaN								HNSCC(10;0.0054)			0	0	0	0.02938	0	6	95									
RBM16	22828	broad.mit.edu	37	6	155154524	155154524	+	Missense_Mutation	SNP	A	A	G			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr6:155154524A>G	uc003qqa.2	+	21	4043	c.3811A>G	c.(3811-3813)ACA>GCA	p.T1271A	TIAM2_uc003qqb.2_5'UTR|RBM16_uc011efj.1_Missense_Mutation_p.T1337A|RBM16_uc011efk.1_Missense_Mutation_p.T1316A|RBM16_uc003qpz.2_Missense_Mutation_p.T1271A	NM_014892	NP_055707	Q9UPN6	SCAF8_HUMAN	RNA-binding motif protein 16	1271					mRNA processing|RNA splicing	nuclear matrix|spliceosomal complex	nucleotide binding|RNA binding|RNA polymerase core enzyme binding				0		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;2.33e-15)|BRCA - Breast invasive adenocarcinoma(81;0.00524)		AACTGAGGGGACATAATCATC	0.373		NaN											0	0	0	0.09836	0	35	22									
TULP4	56995	broad.mit.edu	37	6	158922867	158922867	+	Silent	SNP	G	G	A			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr6:158922867G>A	uc003qrf.2	+	13	3529	c.2172G>A	c.(2170-2172)CTG>CTA	p.L724L	TULP4_uc003qrg.2_Intron	NM_020245	NP_064630	Q9NRJ4	TULP4_HUMAN	tubby like protein 4 isoform 1	724					intracellular signal transduction|response to nutrient	cytoplasm	protein binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1		Breast(66;0.000781)|Ovarian(120;0.0308)|Lung SC(201;0.164)|Prostate(117;0.171)		OV - Ovarian serous cystadenocarcinoma(65;1.64e-18)|BRCA - Breast invasive adenocarcinoma(81;2.67e-05)		TAGATGTCCTGACCAACCAGA	0.567		NaN											0	0	0	0.139131	0	83	34									
IGF2R	3482	broad.mit.edu	37	6	160500774	160500774	+	Missense_Mutation	SNP	G	G	C			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr6:160500774G>C	uc003qta.2	+	38	5789	c.5641G>C	c.(5641-5643)GAA>CAA	p.E1881Q		NM_000876	NP_000867	P11717	MPRI_HUMAN	insulin-like growth factor 2 receptor precursor	1881	13.|Lumenal (Potential).				receptor-mediated endocytosis	cell surface|endocytic vesicle|endosome|integral to plasma membrane|lysosomal membrane|trans-Golgi network transport vesicle	glycoprotein binding|insulin-like growth factor receptor activity|phosphoprotein binding|transporter activity			ovary(3)	3		Breast(66;0.000777)|Ovarian(120;0.0305)		OV - Ovarian serous cystadenocarcinoma(65;2.45e-17)|BRCA - Breast invasive adenocarcinoma(81;1.09e-05)		GCACCAGGATGAAGCGGTCGT	0.458		NaN											0	0	0	0.080422	0	29	18									
MICALL2	79778	broad.mit.edu	37	7	1481960	1481960	+	Missense_Mutation	SNP	G	G	C			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr7:1481960G>C	uc003skj.3	-	7	1726	c.1579C>G	c.(1579-1581)CAG>GAG	p.Q527E	MICALL2_uc003ski.3_Missense_Mutation_p.Q14E	NM_182924	NP_891554	Q8IY33	MILK2_HUMAN	MICAL-like 2 isoform 1	527						cytoplasm|cytoskeleton	zinc ion binding			central_nervous_system(1)	1		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0178)|OV - Ovarian serous cystadenocarcinoma(56;6.01e-15)		GCGGATGCCTGAGAGGTACTG	0.667		NaN											0	0	0	0.139131	0	50	92									
IL6	3569	broad.mit.edu	37	7	22768323	22768323	+	Missense_Mutation	SNP	G	G	C			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr7:22768323G>C	uc011jyn.1	+	4	681	c.222G>C	c.(220-222)AAG>AAC	p.K74N	uc010kun.1_5'Flank|IL6_uc011jyo.1_Missense_Mutation_p.K74N|IL6_uc011jyp.1_5'UTR|IL6_uc003svj.3_Missense_Mutation_p.K74N|IL6_uc011jyq.1_Missense_Mutation_p.K128N	NM_000600	NP_000591	P05231	IL6_HUMAN	interleukin 6 precursor	74					acute-phase response|cellular response to hydrogen peroxide|defense response to Gram-negative bacterium|defense response to Gram-positive bacterium|defense response to virus|endocrine pancreas development|glucagon secretion|hepatic immune response|interleukin-6-mediated signaling pathway|negative regulation of apoptosis|negative regulation of cell proliferation|negative regulation of chemokine biosynthetic process|negative regulation of collagen biosynthetic process|negative regulation of fat cell differentiation|negative regulation of lipid storage|neuron projection development|neutrophil apoptosis|platelet activation|positive regulation of acute inflammatory response|positive regulation of anti-apoptosis|positive regulation of B cell activation|positive regulation of chemokine production|positive regulation of immunoglobulin secretion|positive regulation of interleukin-6 production|positive regulation of osteoblast differentiation|positive regulation of peptidyl-serine phosphorylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of smooth muscle cell proliferation|positive regulation of T cell proliferation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of translation|positive regulation of tyrosine phosphorylation of Stat3 protein|regulation of vascular endothelial growth factor production|response to glucocorticoid stimulus|response to peptidoglycan	extracellular space|interleukin-6 receptor complex	cytokine activity|growth factor activity|interleukin-6 receptor binding				0					Arsenic trioxide(DB01169)|Bicalutamide(DB01128)|Ginseng(DB01404)|Simvastatin(DB00641)	CATGTAACAAGAGTAACATGT	0.428		NaN											0	0	0	0.014758	0	5	59									
NUPL2	11097	broad.mit.edu	37	7	23239972	23239972	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr7:23239972G>A	uc003svu.2	+	7	1139	c.880G>A	c.(880-882)GAA>AAA	p.E294K	NUPL2_uc003svv.2_RNA|NUPL2_uc003svw.2_Missense_Mutation_p.E171K|NUPL2_uc011jyw.1_RNA|NUPL2_uc003svx.2_Missense_Mutation_p.E171K|NUPL2_uc011jyx.1_Missense_Mutation_p.E66K	NM_007342	NP_031368	O15504	NUPL2_HUMAN	nucleoporin like 2	294	Ser-rich.				carbohydrate metabolic process|glucose transport|mRNA transport|protein export from nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear membrane|nuclear pore	nuclear export signal receptor activity|nucleic acid binding|zinc ion binding			skin(2)|ovary(1)	3						TGGGAAGCCTGAAGTCACATC	0.502		NaN											0	0	0	0.047766	0	9	10									
ASB4	51666	broad.mit.edu	37	7	95165794	95165794	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr7:95165794G>A	uc011kij.1	+	4	1024	c.1024G>A	c.(1024-1026)GTC>ATC	p.V342I		NM_016116	NP_057200	Q9Y574	ASB4_HUMAN	ankyrin repeat and SOCS box-containing protein 4	342					intracellular signal transduction					central_nervous_system(1)	1	all_cancers(62;2.27e-10)|all_epithelial(64;2.28e-09)|Lung NSC(181;0.218)|all_lung(186;0.246)		STAD - Stomach adenocarcinoma(171;0.0151)			TGAAGTTGTAGTCAATGCCTA	0.408		NaN											0	0	0	0.146539	0	13	43									
SRPK2	6733	broad.mit.edu	37	7	104758350	104758350	+	Missense_Mutation	SNP	C	C	G			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr7:104758350C>G	uc003vct.2	-	15	2189	c.2002G>C	c.(2002-2004)GAA>CAA	p.E668Q	SRPK2_uc003vcu.2_Missense_Mutation_p.E668Q|SRPK2_uc003vcv.2_Missense_Mutation_p.E679Q|uc003vcr.1_5'Flank|SRPK2_uc003vcs.1_RNA	NM_182691	NP_872633	P78362	SRPK2_HUMAN	serine/arginine-rich protein-specific kinase 2	668	Protein kinase.				angiogenesis|cell differentiation|intracellular protein kinase cascade|negative regulation of viral genome replication|nuclear speck organization|positive regulation of cell cycle|positive regulation of cell proliferation|positive regulation of gene expression|positive regulation of neuron apoptosis|positive regulation of viral genome replication|spliceosome assembly	cytoplasm|nucleolus	14-3-3 protein binding|ATP binding|magnesium ion binding|protein serine/threonine kinase activity			central_nervous_system(3)|ovary(2)|upper_aerodigestive_tract(1)	6						GGAACCATTTCTAACATCGGG	0.458		NaN											0	0	0	0.146539	0	14	31									
COG5	10466	broad.mit.edu	37	7	106938761	106938761	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr7:106938761C>T	uc003ved.2	-	12	1757	c.1232G>A	c.(1231-1233)GGA>GAA	p.G411E	COG5_uc003vec.2_Missense_Mutation_p.G411E|COG5_uc003vee.2_Missense_Mutation_p.G411E	NM_181733	NP_859422	Q9UP83	COG5_HUMAN	component of oligomeric golgi complex 5 isoform	411					intra-Golgi vesicle-mediated transport|protein transport	cytosol|Golgi membrane|Golgi transport complex|nucleus	protein binding			central_nervous_system(2)|skin(2)	4						AGGGTATTCTCCTTCAAATGC	0.323		NaN											0	0	0	0.105934	0	11	26									
MKRN1	23608	broad.mit.edu	37	7	140158900	140158900	+	Silent	SNP	C	C	T			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr7:140158900C>T	uc003vvt.2	-	4	903	c.678G>A	c.(676-678)GAG>GAA	p.E226E	MKRN1_uc003vvs.2_Silent_p.E162E|MKRN1_uc011krd.1_Intron|MKRN1_uc003vvv.3_Silent_p.E226E|MKRN1_uc003vvu.3_Silent_p.E162E	NM_013446	NP_038474	Q9UHC7	MKRN1_HUMAN	makorin ring finger protein 1 isoform 1	226	C3H1-type 3.						ligase activity|nucleic acid binding|protein binding|zinc ion binding			ovary(1)	1	Melanoma(164;0.00956)					ACACACAGTTCTCCCCGTATC	0.532		NaN											0	0	0	0.139131	0	43	97									
DENND2A	27147	broad.mit.edu	37	7	140273705	140273705	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr7:140273705G>A	uc010lnj.2	-	4	1494	c.1349C>T	c.(1348-1350)TCC>TTC	p.S450F	DENND2A_uc011kre.1_RNA|DENND2A_uc010lnk.2_Missense_Mutation_p.S450F|DENND2A_uc003vvw.2_Missense_Mutation_p.S450F|DENND2A_uc003vvx.2_Missense_Mutation_p.S450F	NM_015689	NP_056504	Q9ULE3	DEN2A_HUMAN	DENN/MADD domain containing 2A	450										ovary(3)|breast(1)	4	Melanoma(164;0.00956)					GCTGATTTTGGAAGGGGACCC	0.498		NaN											0	0	0	0.139131	0	42	109									
CASP2	835	broad.mit.edu	37	7	142985599	142985599	+	Silent	SNP	G	G	T			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr7:142985599G>T	uc003wco.2	+	1	198	c.51G>T	c.(49-51)CTG>CTT	p.L17L	CASP2_uc003wcp.2_Silent_p.L17L|CASP2_uc011kta.1_5'UTR|CASP2_uc003wcq.2_5'Flank	NM_032982	NP_116764	P42575	CASP2_HUMAN	caspase 2 isoform 1 preproprotein	17					apoptosis|cellular response to mechanical stimulus|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|protein maturation by peptide bond cleavage	cytosol	cysteine-type endopeptidase activity|enzyme binding|protein binding|protein domain specific binding			lung(2)|ovary(1)	3	Melanoma(164;0.059)					ACAAGGAGCTGATGGCCGCTG	0.682		NaN											1	0	0.00198382	0.02938	0.00201963	4	14									
MLL3	58508	broad.mit.edu	37	7	151949045	151949045	+	Nonsense_Mutation	SNP	C	C	A			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08			C	A	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr7:151949045C>A	uc003wla.2	-	11	1819	c.1600G>T	c.(1600-1602)GAG>TAG	p.E534*		NM_170606	NP_733751	Q8NEZ4	MLL3_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 3	534					intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			large_intestine(27)|pancreas(13)|ovary(9)|central_nervous_system(8)|breast(3)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	63	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)		TCAGCTATCTCCACTTCCTCA	0.358		NaN	N		medulloblastoma								1	0	2.27111e-07	0.09319	2.3633e-07	9	16									
VIPR2	7434	broad.mit.edu	37	7	158827298	158827298	+	Nonsense_Mutation	SNP	G	G	A			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr7:158827298G>A	uc003woh.2	-	9	1039	c.853C>T	c.(853-855)CGA>TGA	p.R285*	VIPR2_uc010lqx.2_RNA|VIPR2_uc010lqy.2_RNA	NM_003382	NP_003373	P41587	VIPR2_HUMAN	vasoactive intestinal peptide receptor 2	285	Helical; Name=5; (Potential).				cell-cell signaling	integral to plasma membrane				lung(1)|central_nervous_system(1)	2	Ovarian(565;0.152)	all_cancers(7;1.13e-11)|all_epithelial(9;0.000545)|all_hematologic(28;0.00603)	OV - Ovarian serous cystadenocarcinoma(82;0.00231)	UCEC - Uterine corpus endometrioid carcinoma (81;0.2)|STAD - Stomach adenocarcinoma(7;0.18)		ATCGGTATTCGTATGACCCAC	0.478		NaN											0	0	0	0.062417	0	18	47									
UBXN8	7993	broad.mit.edu	37	8	30620854	30620854	+	Silent	SNP	C	C	T			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr8:30620854C>T	uc003xii.2	+	9	653	c.636C>T	c.(634-636)TAC>TAT	p.Y212Y	UBXN8_uc010lvi.2_3'UTR|UBXN8_uc011lbb.1_RNA|UBXN8_uc003xij.2_RNA	NM_005671	NP_005662	O00124	UBXN8_HUMAN	reproduction 8	212	UBX.				single fertilization						0						TGAAGTCCTACAGCTCACAGG	0.428		NaN											0	0	0	0.139131	0	35	28									
KCNU1	157855	broad.mit.edu	37	8	36642052	36642052	+	Silent	SNP	C	C	T			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr8:36642052C>T	uc010lvw.2	+	1	211	c.124C>T	c.(124-126)CTG>TTG	p.L42L	KCNU1_uc003xjw.2_RNA	NM_001031836	NP_001027006	A8MYU2	KCNU1_HUMAN	potassium channel, subfamily U, member 1	42	Helical; Name=Segment S0; (Potential).					voltage-gated potassium channel complex	binding|large conductance calcium-activated potassium channel activity|voltage-gated potassium channel activity			ovary(1)	1				KIRC - Kidney renal clear cell carcinoma(67;0.0504)|Kidney(114;0.0634)		ACTCATCATCCTGTTGATCTT	0.428		NaN											0	0	0	0.069234	0	8	19									
GGH	8836	broad.mit.edu	37	8	63939794	63939794	+	Silent	SNP	G	G	C			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr8:63939794G>C	uc003xuw.2	-	4	589	c.306C>G	c.(304-306)CTC>CTG	p.L102L		NM_003878	NP_003869	Q92820	GGH_HUMAN	gamma-glutamyl hydrolase precursor	102	Gamma-glutamyl hydrolase.				glutamine metabolic process	extracellular space|lysosome|melanosome	gamma-glutamyl-peptidase activity				0	Breast(64;0.0716)	all_cancers(86;0.189)|Lung NSC(129;0.0324)|all_lung(136;0.0593)|all_epithelial(80;0.131)			Folic Acid(DB00158)|L-Glutamic Acid(DB00142)	CTGAGCGTCTGAGGTCAACAC	0.383		NaN											0	0	0	0.131918	0	35	111									
KCNB2	9312	broad.mit.edu	37	8	73849756	73849756	+	Silent	SNP	T	T	C	rs114148959	byFrequency	TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr8:73849756T>C	uc003xzb.2	+	3	2754	c.2166T>C	c.(2164-2166)AAT>AAC	p.N722N		NM_004770	NP_004761	Q92953	KCNB2_HUMAN	potassium voltage-gated channel, Shab-related	722	Cytoplasmic (Potential).				regulation of smooth muscle contraction	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|protein binding			skin(3)|large_intestine(1)|pancreas(1)|ovary(1)|central_nervous_system(1)	7	Breast(64;0.137)		Epithelial(68;0.105)			TTAAGGAAAATAGAGGCAGTG	0.537		NaN											0	0	0	0.139131	0	64	54									
SNX31	169166	broad.mit.edu	37	8	101629926	101629926	+	Silent	SNP	A	A	G			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr8:101629926A>G	uc003yjr.2	-	5	505	c.354T>C	c.(352-354)TAT>TAC	p.Y118Y	SNX31_uc011lhb.1_Silent_p.Y19Y	NM_152628	NP_689841	Q8N9S9	SNX31_HUMAN	sorting nexin 31	118					cell communication|protein transport		phosphatidylinositol binding				0	all_cancers(14;4.01e-05)|all_epithelial(15;1.26e-07)|Lung NSC(17;0.000453)|all_lung(17;0.00125)		Epithelial(11;1.21e-11)|all cancers(13;2.62e-09)|OV - Ovarian serous cystadenocarcinoma(57;3.22e-06)|STAD - Stomach adenocarcinoma(118;0.206)			ATATGTCCAGATAAGCTTTCT	0.303		NaN											0	0	0	0.086207	0	32	105									
CSMD3	114788	broad.mit.edu	37	8	114185980	114185981	+	Missense_Mutation	DNP	GA	GA	AT			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr8:114185980_114185981GA>AT	uc003ynu.2	-	4	838_839	c.679_680TC>AT	c.(679-681)TCG>ATG	p.S227M	CSMD3_uc003ynt.2_Missense_Mutation_p.S187M|CSMD3_uc011lhx.1_Missense_Mutation_p.S227M|CSMD3_uc010mcx.1_Missense_Mutation_p.S227M	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	227	Extracellular (Potential).|Sushi 1.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						AAAATCCCACGAAGCTGTATTA	0.431		NaN								HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			0	0	0	0.115264	0	41	138									
ATAD2	29028	broad.mit.edu	37	8	124382256	124382256	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr8:124382256C>T	uc003yqh.3	-	7	844	c.736G>A	c.(736-738)GAA>AAA	p.E246K	ATAD2_uc011lii.1_Missense_Mutation_p.E37K|ATAD2_uc003yqi.3_RNA|ATAD2_uc003yqj.2_Missense_Mutation_p.E246K	NM_014109	NP_054828	Q6PL18	ATAD2_HUMAN	ATPase family, AAA domain containing 2	246					regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrion|nucleus	ATP binding|ATPase activity			ovary(2)	2	Lung NSC(37;1.25e-09)|Ovarian(258;0.00838)		STAD - Stomach adenocarcinoma(47;0.00288)			TCACCCTCTTCAGATGACTCT	0.234		NaN											0	0	0	0.139131	0	45	44									
RHPN1	114822	broad.mit.edu	37	8	144457813	144457813	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr8:144457813C>T	uc003yyb.2	+	2	284	c.151C>T	c.(151-153)CGG>TGG	p.R51W		NM_052924	NP_443156	Q8TCX5	RHPN1_HUMAN	rhophilin 1	51	REM.				signal transduction	intracellular				large_intestine(1)	1	all_cancers(97;7.39e-11)|all_epithelial(106;5.44e-09)|Lung NSC(106;0.000167)|all_lung(105;0.000459)|Ovarian(258;0.0212)|Acute lymphoblastic leukemia(118;0.155)		Colorectal(110;0.107)|BRCA - Breast invasive adenocarcinoma(115;0.156)			GCTGCAGATGCGGACGGGCGC	0.672		NaN											0	0	0	0.144211	0	24	20									
GPR172A	79581	broad.mit.edu	37	8	145583069	145583069	+	Missense_Mutation	SNP	A	A	G			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr8:145583069A>G	uc003zcc.1	+	2	273	c.116A>G	c.(115-117)AAA>AGA	p.K39R	FBXL6_uc003zbz.2_5'Flank|FBXL6_uc003zca.2_5'Flank|FBXL6_uc003zcb.2_5'Flank|FBXL6_uc010mfx.2_5'Flank|GPR172A_uc003zcd.1_Missense_Mutation_p.K39R|GPR172A_uc003zce.1_Missense_Mutation_p.K39R|GPR172A_uc010mfy.1_Missense_Mutation_p.K39R|GPR172A_uc003zcf.1_Missense_Mutation_p.K39R|GPR172A_uc011llc.1_Intron	NM_024531	NP_078807	Q9HAB3	RFT3_HUMAN	G protein-coupled receptor 172A precursor	39						integral to plasma membrane	receptor activity|riboflavin transporter activity				0	all_cancers(97;6.64e-12)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;4.43e-40)|Epithelial(56;1.48e-39)|all cancers(56;1.49e-34)|BRCA - Breast invasive adenocarcinoma(115;0.0441)|Colorectal(110;0.055)			GTGGTGGTCAAAGAGCTTCCA	0.647		NaN											0	0	0	0.115264	0	3	40									
TLE1	7088	broad.mit.edu	37	9	84235445	84235445	+	Silent	SNP	G	G	A			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr9:84235445G>A	uc004aly.2	-	9	1063	c.622C>T	c.(622-624)CTA>TTA	p.L208L	TLE1_uc004alz.2_Silent_p.L218L|TLE1_uc011lsr.1_Silent_p.L208L|TLE1_uc004ama.1_Silent_p.L208L|TLE1_uc011lss.1_Silent_p.L134L	NM_005077	NP_005068	Q04724	TLE1_HUMAN	transducin-like enhancer protein 1	208	CCN domain.				negative regulation of Wnt receptor signaling pathway|organ morphogenesis|transcription, DNA-dependent|Wnt receptor signaling pathway		transcription factor binding			ovary(1)|skin(1)	2						GTGCCTCTTAGACTGTCTGGG	0.408		NaN											0	0	0	0.043863	0	16	50									
SUSD3	203328	broad.mit.edu	37	9	95840160	95840160	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr9:95840160G>A	uc004atb.2	+	3	346	c.310G>A	c.(310-312)GTG>ATG	p.V104M	SUSD3_uc004atc.2_Missense_Mutation_p.V91M	NM_145006	NP_659443	Q96L08	SUSD3_HUMAN	sushi domain containing 3	104	Helical; (Potential).					integral to membrane				breast(2)|skin(2)|ovary(1)|lung(1)	6						TGGCTTCAAGGTGGCCGTGAT	0.597		NaN											0	0	0	0.059317	0	27	33									
ZNF462	58499	broad.mit.edu	37	9	109688322	109688322	+	Missense_Mutation	SNP	C	C	G			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr9:109688322C>G	uc004bcz.2	+	3	2418	c.2129C>G	c.(2128-2130)ACC>AGC	p.T710S	ZNF462_uc010mto.2_Missense_Mutation_p.T558S|ZNF462_uc004bda.2_Missense_Mutation_p.T558S	NM_021224	NP_067047	Q96JM2	ZN462_HUMAN	zinc finger protein 462	710					transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(5)	5						ATTAACCAAACCAAACAGCAG	0.453		NaN											0	0	0	0.086207	0	36	70									
AK1	203	broad.mit.edu	37	9	130630320	130630320	+	Silent	SNP	G	G	A			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr9:130630320G>A	uc004bsm.3	-	7	705	c.552C>T	c.(550-552)TCC>TCT	p.S184S		NM_000476	NP_000467	P00568	KAD1_HUMAN	adenylate kinase 1	184					ATP metabolic process|nucleobase, nucleoside and nucleotide interconversion	cytosol	adenylate kinase activity|ATP binding|protein binding				0						TGCAGACCTGGGAGAAGACAC	0.662		NaN											0	0	0	0.076483	0	20	41									
ST6GALNAC4	27090	broad.mit.edu	37	9	130670821	130670821	+	Missense_Mutation	SNP	C	C	G			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr9:130670821C>G	uc004bss.2	-	6	1035	c.759G>C	c.(757-759)GAG>GAC	p.E253D	ST6GALNAC4_uc004bst.2_Missense_Mutation_p.E169D	NM_175039	NP_778204	Q9H4F1	SIA7D_HUMAN	sialyltransferase 7D isoform a	253	Lumenal (Potential).				glycolipid metabolic process|protein glycosylation	integral to Golgi membrane|nucleus|soluble fraction	(alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3)-N-acetyl-galactosaminide 6-alpha-sialyltransferase activity				0						GCCGGCCCTTCTCAAAGTAGT	0.647		NaN											0	0	0	0.139131	0	44	48									
FAM102A	399665	broad.mit.edu	37	9	130742369	130742369	+	Silent	SNP	G	G	A			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr9:130742369G>A	uc004bsx.1	-	1	127	c.48C>T	c.(46-48)TTC>TTT	p.F16F		NM_001035254	NP_001030331	Q5T9C2	F102A_HUMAN	early estrogen-induced gene 1 protein isoform a	16										ovary(1)	1						CCTCCAGGGTGAAAGTAGTTT	0.522		NaN											0	0	0	0.139131	0	51	107									
AGPAT2	10555	broad.mit.edu	37	9	139571568	139571568	+	Nonsense_Mutation	SNP	C	C	A			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr9:139571568C>A	uc004cii.1	-	3	439	c.337G>T	c.(337-339)GAG>TAG	p.E113*	AGPAT2_uc004cij.1_Nonsense_Mutation_p.E113*	NM_006412	NP_006403	O15120	PLCB_HUMAN	1-acylglycerol-3-phosphate O-acyltransferase 2	113					phosphatidic acid biosynthetic process|positive regulation of cytokine production|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane	1-acylglycerol-3-phosphate O-acyltransferase activity				0	all_cancers(76;0.0893)|all_epithelial(76;0.231)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;9.87e-06)|Epithelial(140;0.000123)		ACGCAGCGCTCCGGAAGGACC	0.547		NaN											1	0	0.00621372	0.058154	0.00630312	9	22									
COBRA1	25920	broad.mit.edu	37	9	140151344	140151344	+	Silent	SNP	G	G	A			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr9:140151344G>A	uc004cmm.3	+	4	638	c.435G>A	c.(433-435)GTG>GTA	p.V145V		NM_015456	NP_056271	Q8WX92	NELFB_HUMAN	cofactor of BRCA1	145					negative regulation of transcription, DNA-dependent|positive regulation of viral transcription|transcription elongation from RNA polymerase II promoter|viral reproduction	cytoplasm|nucleoplasm	protein binding				0	all_cancers(76;0.0926)		STAD - Stomach adenocarcinoma(284;0.137)	OV - Ovarian serous cystadenocarcinoma(145;9.42e-05)|Epithelial(140;0.000766)		CCGTGGAGGTGAAGCGGCAGA	0.567		NaN											0	0	0	0.058154	0	7	35									
FAM47C	442444	broad.mit.edu	37	X	37027156	37027156	+	Missense_Mutation	SNP	C	C	G			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chrX:37027156C>G	uc004ddl.1	+	1	687	c.673C>G	c.(673-675)CAG>GAG	p.Q225E		NM_001013736	NP_001013758	Q5HY64	FA47C_HUMAN	hypothetical protein LOC442444	225										ovary(3)	3						TCTCCGCCCACAGCCTCCCAA	0.647		NaN											0	0	0	0.021553	0	4	72									
MSN	4478	broad.mit.edu	37	X	64959692	64959692	+	Silent	SNP	G	G	A			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chrX:64959692G>A	uc004dwf.2	+	13	1869	c.1671G>A	c.(1669-1671)AAG>AAA	p.K557K		NM_002444	NP_002435	P26038	MOES_HUMAN	moesin	557					leukocyte cell-cell adhesion|leukocyte migration|membrane to membrane docking	apical plasma membrane|cytoskeleton|extrinsic to membrane|microvillus membrane|nucleolus	cell adhesion molecule binding|receptor binding|structural constituent of cytoskeleton		MSN/ALK(6)	haematopoietic_and_lymphoid_tissue(6)|ovary(3)|lung(1)	10						ACAAATACAAGACCCTGCGCC	0.547		NaN	T	ALK	ALCL								0	0	0	0.139131	0	43	58									
ACRC	93953	broad.mit.edu	37	X	70823836	70823836	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chrX:70823836G>A	uc004eae.2	+	8	1210	c.709G>A	c.(709-711)GAC>AAC	p.D237N	BCYRN1_uc011mpt.1_Intron	NM_052957	NP_443189	Q96QF7	ACRC_HUMAN	ACRC protein	237	Asp/Ser-rich.					nucleus				ovary(3)	3	Renal(35;0.156)					TGTTCCCGACGACAGCAGTGA	0.537		NaN											0	0	0	0.139131	0	248	47									
PAK3	5063	broad.mit.edu	37	X	110439755	110439755	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chrX:110439755G>A	uc004epa.2	+	13	1366	c.1339G>A	c.(1339-1341)GAG>AAG	p.E447K	PAK3_uc010npt.1_Missense_Mutation_p.E432K|PAK3_uc010npu.1_Missense_Mutation_p.E432K|PAK3_uc004eoy.1_Missense_Mutation_p.E187K|PAK3_uc004eoz.2_Missense_Mutation_p.E432K|PAK3_uc011mst.1_RNA|PAK3_uc010npv.1_Missense_Mutation_p.E468K|PAK3_uc010npw.1_Missense_Mutation_p.E453K	NM_001128173	NP_001121645	O75914	PAK3_HUMAN	p21-activated kinase 3 isoform d	447	Protein kinase.				multicellular organismal development		ATP binding|metal ion binding|protein serine/threonine kinase activity|SH3 domain binding			lung(6)|ovary(3)|large_intestine(1)	10						GATGGCACCTGAGGTGGTGAC	0.468		NaN								TSP Lung(19;0.15)			0	0	0	0.139131	0	49	57									
KLHL13	90293	broad.mit.edu	37	X	117053581	117053581	+	Missense_Mutation	SNP	G	G	C			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chrX:117053581G>C	uc004eql.2	-	4	535	c.473C>G	c.(472-474)TCT>TGT	p.S158C	KLHL13_uc004eqk.2_Missense_Mutation_p.S107C|KLHL13_uc011mtn.1_5'UTR|KLHL13_uc011mto.1_Missense_Mutation_p.S152C|KLHL13_uc011mtp.1_Missense_Mutation_p.S160C|KLHL13_uc004eqm.2_Missense_Mutation_p.S107C|KLHL13_uc011mtq.1_Missense_Mutation_p.S142C	NM_033495	NP_277030	Q9P2N7	KLH13_HUMAN	kelch-like 13	158	BTB.				cytokinesis|mitosis|protein ubiquitination	Cul3-RING ubiquitin ligase complex				kidney(1)|skin(1)	2						CATATTAAGAGAAAGCTTTGC	0.383		NaN											0	0	0	0.099896	0	23	43									
CDR1	1038	broad.mit.edu	37	X	139866322	139866322	+	Silent	SNP	C	C	T			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chrX:139866322C>T	uc004fbg.1	-	1	402	c.210G>A	c.(208-210)TCG>TCA	p.S70S	uc004fbf.1_RNA	NM_004065	NP_004056	P51861	CDR1_HUMAN	cerebellar degeneration-related protein 1,	70	23 X 6 AA approximate repeats.|12.										0	Acute lymphoblastic leukemia(192;7.65e-05)	Lung SC(4;0.051)				CCATAGCTTCCGAAAAATCCA	0.458		NaN											0	0	0	0.115264	0	3	48									
SPANXN2	494119	broad.mit.edu	37	X	142795255	142795255	+	Silent	SNP	C	C	T			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chrX:142795255C>T	uc004fbz.2	-	2	1177	c.423G>A	c.(421-423)CTG>CTA	p.L141L		NM_001009615	NP_001009615	Q5MJ10	SPXN2_HUMAN	SPANX-N2 protein	141										ovary(1)	1	Acute lymphoblastic leukemia(192;6.56e-05)					CAGATGAGTCCAGGTCTTCGT	0.517		NaN											0	0	0	0.105934	0	6	227									
MAGEA6	4105	broad.mit.edu	37	X	151870055	151870055	+	Missense_Mutation	SNP	T	T	C	rs140963484	byFrequency	TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chrX:151870055T>C	uc004ffq.1	+	3	939	c.745T>C	c.(745-747)TAT>CAT	p.Y249H	MAGEA6_uc004ffr.1_Missense_Mutation_p.Y249H|MAGEA2_uc010nto.2_Intron	NM_005363	NP_005354	P43360	MAGA6_HUMAN	melanoma antigen family A, 6	249	MAGE.						protein binding				0	Acute lymphoblastic leukemia(192;6.56e-05)					GCTCACCCAATATTTCGTGCA	0.547		NaN											0	0	0	0.083992	0	21	89									
MAGEA3	4102	broad.mit.edu	37	X	151935357	151935357	+	Silent	SNP	T	T	C	rs35014597	byFrequency	TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chrX:151935357T>C	uc004fgp.2	-	3	1019	c.810A>G	c.(808-810)GAA>GAG	p.E270E		NM_005362	NP_005353	P43357	MAGA3_HUMAN	melanoma antigen family A, 3	270	MAGE.										0	Acute lymphoblastic leukemia(192;6.56e-05)					CCCACAGGAATTCATAACATG	0.532		NaN											0	0	0	0.038147	0	4	145									
MAGEA3	4102	broad.mit.edu	37	X	151935363	151935363	+	Silent	SNP	A	A	G	rs35137903	by1000genomes	TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chrX:151935363A>G	uc004fgp.2	-	3	1013	c.804T>C	c.(802-804)TGT>TGC	p.C268C		NM_005362	NP_005353	P43357	MAGA3_HUMAN	melanoma antigen family A, 3	268	MAGE.										0	Acute lymphoblastic leukemia(192;6.56e-05)					GGAATTCATAACATGCAGGAT	0.517		NaN											0	0	0	0.080935	0	7	138									
HCFC1	3054	broad.mit.edu	37	X	153224926	153224926	+	Silent	SNP	G	G	A			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chrX:153224926G>A	uc004fjp.2	-	9	1989	c.1461C>T	c.(1459-1461)CTC>CTT	p.L487L		NM_005334	NP_005325	P51610	HCFC1_HUMAN	host cell factor 1	487					cell cycle|interspecies interaction between organisms|positive regulation of cell cycle|positive regulation of gene expression|protein stabilization|reactivation of latent virus|regulation of protein complex assembly|transcription from RNA polymerase II promoter	mitochondrion|MLL1 complex|MLL5-L complex|Set1C/COMPASS complex	chromatin binding|identical protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			ovary(2)	2	all_cancers(53;6.23e-16)|all_epithelial(53;5.61e-10)|all_lung(58;3.99e-07)|Lung NSC(58;5.02e-07)|all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					CGGTCACTTTGAGAACAGCAG	0.612		NaN											0	0	0	0.049695	0	16	26									
TIGD3	220359	broad.mit.edu	37	11	65124162	65124162	+	Frame_Shift_Del	DEL	C	C	-			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr11:65124162delC	uc001odo.3	+	2	1046	c.883delC	c.(883-885)CCCfs	p.P295fs		NM_145719	NP_663771	Q6B0B8	TIGD3_HUMAN	tigger transposable element derived 3	295	DDE.				regulation of transcription, DNA-dependent	chromosome, centromeric region|nucleus	DNA binding				0						CACCACGCCTCCCCTGCCCAG	0.652		NaN											NaN	NaN	NaN	NaN	NaN	24	69	---	---							
LTBP3	4054	broad.mit.edu	37	11	65315174	65315174	+	Frame_Shift_Del	DEL	C	C	-			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr11:65315174delC	uc001oej.2	-	13	2234	c.1965delG	c.(1963-1965)GGGfs	p.G655fs	LTBP3_uc001oeg.2_5'Flank|LTBP3_uc001oeh.2_Frame_Shift_Del_p.G85fs|LTBP3_uc010roi.1_Frame_Shift_Del_p.G538fs|LTBP3_uc001oei.2_Frame_Shift_Del_p.G655fs|LTBP3_uc010roj.1_Frame_Shift_Del_p.G356fs|LTBP3_uc010rok.1_Frame_Shift_Del_p.G566fs	NM_001130144	NP_001123616	Q9NS15	LTBP3_HUMAN	latent transforming growth factor beta binding	655	EGF-like 4; calcium-binding (Potential).|Cys-rich.					extracellular region	calcium ion binding|growth factor binding			central_nervous_system(2)|lung(1)	3						CGCACGAGCGCCCCCCGGCGC	0.736		NaN											NaN	NaN	NaN	NaN	NaN	2	4	---	---							
CHRNA3	1136	broad.mit.edu	37	15	78913068	78913070	+	In_Frame_Del	DEL	CAG	CAG	-	rs66793222		TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr15:78913068_78913070delCAG	uc002bec.2	-	1	253_255	c.67_69delCTG	c.(67-69)CTGdel	p.L23del	CHRNA3_uc002bea.2_RNA|CHRNA3_uc002beb.2_In_Frame_Del_p.L23del	NM_000743	NP_000734	P32297	ACHA3_HUMAN	cholinergic receptor, nicotinic, alpha 3	23			Missing.		activation of transmembrane receptor protein tyrosine kinase activity|behavioral response to nicotine|locomotory behavior|regulation of acetylcholine secretion|regulation of dendrite morphogenesis|regulation of excitatory postsynaptic membrane potential|regulation of smooth muscle contraction|synaptic transmission involved in micturition|synaptic transmission, cholinergic	cell junction|dendrite|neuronal cell body|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic density|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity			central_nervous_system(3)|ovary(1)	4						gcagcagagacagcagcagcagc	0.601		NaN											NaN	NaN	NaN	NaN	NaN	3	6	---	---							
SCRT2	85508	broad.mit.edu	37	20	644846	644847	+	Frame_Shift_Ins	INS	-	-	C			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr20:644846_644847insC	uc002wec.2	-	2	970_971	c.392_393insG	c.(391-393)GGCfs	p.G131fs	SRXN1_uc002web.2_Intron	NM_033129	NP_149120	Q9NQ03	SCRT2_HUMAN	scratch 2 protein	131					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						cgtctcccgagccccccgcgtc	0.347		NaN											NaN	NaN	NaN	NaN	NaN	2	4	---	---							
BCL2L1	598	broad.mit.edu	37	20	30309591	30309591	+	Frame_Shift_Del	DEL	A	A	-			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr20:30309591delA	uc002wwl.2	-	2	797	c.431delT	c.(430-432)TTCfs	p.F144fs	BCL2L1_uc002wwk.2_RNA|BCL2L1_uc002wwm.2_Intron|BCL2L1_uc002wwn.2_Frame_Shift_Del_p.F144fs|BCL2L1_uc002wwo.1_Frame_Shift_Del_p.F144fs	NM_138578	NP_612815	Q07817	B2CL1_HUMAN	BCL2-like 1 isoform 1	144	BH1.				induction of apoptosis by intracellular signals|negative regulation of establishment of protein localization in plasma membrane|negative regulation of survival gene product expression|regulation of mitochondrial membrane permeability|regulation of mitochondrial membrane potential|release of cytochrome c from mitochondria|response to cytokine stimulus	integral to membrane|mitochondrial outer membrane|nuclear membrane	BH3 domain binding|identical protein binding			lung(1)|central_nervous_system(1)	2	all_cancers(5;3.47e-06)|all_epithelial(3;1.83e-06)|Lung NSC(7;2.08e-06)|all_lung(7;3.63e-06)|all_hematologic(12;0.158)|Ovarian(7;0.198)		Epithelial(4;2.97e-06)|all cancers(5;3.21e-05)|OV - Ovarian serous cystadenocarcinoma(3;0.00052)|Colorectal(19;0.0055)|COAD - Colon adenocarcinoma(19;0.0264)			GCCGAAGGAGAAAAAGGCCAC	0.542		NaN											NaN	NaN	NaN	NaN	NaN	7	1557	---	---							
SYCP2	10388	broad.mit.edu	37	20	58467047	58467047	+	Frame_Shift_Del	DEL	T	T	-			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr20:58467047delT	uc002yaz.2	-	23	2501	c.2362delA	c.(2362-2364)ATGfs	p.M788fs		NM_014258	NP_055073	Q9BX26	SYCP2_HUMAN	synaptonemal complex protein 2	788					cell division|meiotic prophase I|synaptonemal complex assembly		DNA binding			ovary(3)|lung(2)	5	all_lung(29;0.00344)		BRCA - Breast invasive adenocarcinoma(7;1.19e-09)			AAGCTCACCATTTTTTTTTGT	0.323		NaN											NaN	NaN	NaN	NaN	NaN	7	74	---	---							
ARHGAP39	80728	broad.mit.edu	37	8	145773342	145773344	+	In_Frame_Del	DEL	CTG	CTG	-	rs77462981		TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr8:145773342_145773344delCTG	uc003zdt.1	-	6	1681_1683	c.1126_1128delCAG	c.(1126-1128)CAGdel	p.Q376del	ARHGAP39_uc011llk.1_In_Frame_Del_p.Q376del|ARHGAP39_uc003zds.1_In_Frame_Del_p.Q376del	NM_025251	NP_079527	Q9C0H5	RHG39_HUMAN	KIAA1688 protein	376					axon guidance|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytoskeleton|cytosol|nucleus	GTPase activator activity				0						CGGGACACTTCTGCTTGGTGAGC	0.704		NaN											NaN	NaN	NaN	NaN	NaN	9	4	---	---							
ZNF185	7739	broad.mit.edu	37	X	152087570	152087572	+	In_Frame_Del	DEL	GAG	GAG	-			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chrX:152087570_152087572delGAG	uc010ntv.1	+	7	512_514	c.475_477delGAG	c.(475-477)GAGdel	p.E165del	ZNF185_uc011myg.1_In_Frame_Del_p.E165del|ZNF185_uc011myh.1_In_Frame_Del_p.E165del|ZNF185_uc011myi.1_In_Frame_Del_p.E165del|ZNF185_uc011myj.1_In_Frame_Del_p.E165del|ZNF185_uc011myk.1_In_Frame_Del_p.E165del|ZNF185_uc004fgw.3_In_Frame_Del_p.E30del|ZNF185_uc004fgu.2_5'UTR|ZNF185_uc004fgv.2_5'Flank	NM_007150	NP_009081	O15231	ZN185_HUMAN	zinc finger protein 185	165	Poly-Glu.					cytoplasm|cytoskeleton|focal adhesion	zinc ion binding			ovary(3)	3	Acute lymphoblastic leukemia(192;6.56e-05)					AGGGGACACCgaggaggaggagg	0.522		NaN											NaN	NaN	NaN	NaN	NaN	7	38	---	---