Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	isArtifactMode	oxoGCut	pox	pox_cutoff	qox	t_alt_count	t_ref_count	validation_alt_allele	validation_tumor_sample							
PIK3CD	5293	broad.mit.edu	37	1	9775949	9775949	+	Missense_Mutation	SNP	A	A	G			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr1:9775949A>G	uc001aqb.3	+	5	621	c.413A>G	c.(412-414)GAC>GGC	p.D138G	PIK3CD_uc010oaf.1_Missense_Mutation_p.D138G|PIK3CD_uc001aqe.3_Missense_Mutation_p.D138G	NM_005026	NP_005017	O00329	PK3CD_HUMAN	catalytic phosphatidylinositol 3-kinase delta	138					phosphatidylinositol-mediated signaling|protein phosphorylation	phosphatidylinositol 3-kinase complex|plasma membrane	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity|protein binding			lung(4)|skin(2)|central_nervous_system(1)	7	all_lung(157;0.222)	all_lung(118;2.44e-05)|Lung NSC(185;4.08e-05)|Renal(390;0.000147)|Colorectal(325;0.00205)|Breast(348;0.00314)|Hepatocellular(190;0.00825)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0231)|Colorectal(212;7.52e-08)|COAD - Colon adenocarcinoma(227;1.78e-05)|Kidney(185;0.000322)|KIRC - Kidney renal clear cell carcinoma(229;0.00114)|BRCA - Breast invasive adenocarcinoma(304;0.0021)|STAD - Stomach adenocarcinoma(132;0.00395)|READ - Rectum adenocarcinoma(331;0.0419)		GAAGTGAACGACTTTCGCGCC	0.687		NaN											0	0	0	0.047766	0	9	38									
FBXO42	54455	broad.mit.edu	37	1	16579618	16579618	+	Silent	SNP	G	G	A			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr1:16579618G>A	uc001ayg.2	-	8	1110	c.894C>T	c.(892-894)ATC>ATT	p.I298I	FBXO42_uc001aye.3_Silent_p.I16I|FBXO42_uc001ayf.2_Silent_p.I205I	NM_018994	NP_061867	Q6P3S6	FBX42_HUMAN	F-box protein 42	298	Kelch 4.									upper_aerodigestive_tract(1)|skin(1)	2		Colorectal(325;0.000147)|Renal(390;0.00145)|Breast(348;0.00224)|Lung NSC(340;0.00475)|all_lung(284;0.00671)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0646)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0193)|Colorectal(212;3.16e-07)|COAD - Colon adenocarcinoma(227;1.46e-05)|BRCA - Breast invasive adenocarcinoma(304;4.37e-05)|Kidney(64;0.000246)|KIRC - Kidney renal clear cell carcinoma(64;0.00336)|STAD - Stomach adenocarcinoma(313;0.0139)|READ - Rectum adenocarcinoma(331;0.0693)		ACCCTCCGAGGATTAAGATAG	0.438		NaN											0	0	0	0.124865	0	41	16									
HSPG2	3339	broad.mit.edu	37	1	22202880	22202880	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr1:22202880C>T	uc001bfj.2	-	23	2885	c.2845G>A	c.(2845-2847)GAG>AAG	p.E949K	HSPG2_uc009vqd.2_Missense_Mutation_p.E950K	NM_005529	NP_005520	P98160	PGBM_HUMAN	heparan sulfate proteoglycan 2 precursor	949	Laminin IV type A 2.				angiogenesis|cell adhesion|lipid metabolic process|lipoprotein metabolic process	basement membrane|extracellular space|plasma membrane	protein C-terminus binding			ovary(5)|large_intestine(2)|central_nervous_system(1)|skin(1)	9		Colorectal(325;3.46e-05)|all_lung(284;7.93e-05)|Lung NSC(340;8.71e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0498)|OV - Ovarian serous cystadenocarcinoma(117;1.14e-26)|Colorectal(126;4.18e-07)|COAD - Colon adenocarcinoma(152;1.82e-05)|GBM - Glioblastoma multiforme(114;3.13e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000756)|STAD - Stomach adenocarcinoma(196;0.00656)|KIRC - Kidney renal clear cell carcinoma(1967;0.00942)|READ - Rectum adenocarcinoma(331;0.0721)|Lung(427;0.223)	Becaplermin(DB00102)|Palifermin(DB00039)	TGACCAGGCTCCTCAGAGGCC	0.667		NaN											0	0	0	0.009096	0	4	16									
MACF1	23499	broad.mit.edu	37	1	39799983	39799983	+	Nonsense_Mutation	SNP	C	C	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr1:39799983C>T	uc010oiu.1	+	1	3174	c.3043C>T	c.(3043-3045)CAG>TAG	p.Q1015*	MACF1_uc010ois.1_Intron|MACF1_uc001cda.1_Intron|MACF1_uc001cdc.1_Intron|MACF1_uc001cdb.1_Intron	NM_033044	NP_149033	Q9UPN3	MACF1_HUMAN	microfilament and actin filament cross-linker	2580					cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			ovary(8)|breast(3)|central_nervous_system(3)|skin(2)	16	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			AAGAGAAATCCAGGAGGTTCA	0.378		NaN											0	0	0	0.139131	0	92	39									
MACF1	23499	broad.mit.edu	37	1	39838193	39838193	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr1:39838193G>A	uc010oiu.1	+	16	8589	c.8458G>A	c.(8458-8460)GAA>AAA	p.E2820K	MACF1_uc010ois.1_Missense_Mutation_p.E2318K|MACF1_uc001cda.1_Missense_Mutation_p.E2226K|MACF1_uc001cdc.1_Missense_Mutation_p.E1405K|MACF1_uc001cdb.1_Missense_Mutation_p.E1405K	NM_033044	NP_149033	Q9UPN3	MACF1_HUMAN	microfilament and actin filament cross-linker	4385					cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			ovary(8)|breast(3)|central_nervous_system(3)|skin(2)	16	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			TCTGGTGGAAGAAATCAATTG	0.403		NaN											0	0	0	0.055883	0	22	59									
STIL	6491	broad.mit.edu	37	1	47767248	47767248	+	Silent	SNP	G	G	A			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr1:47767248G>A	uc001crc.1	-	5	593	c.438C>T	c.(436-438)TTC>TTT	p.F146F	TAL1_uc001crb.1_Intron|STIL_uc010omn.1_Silent_p.F146F|STIL_uc010omo.1_Silent_p.F146F|STIL_uc001crd.1_Silent_p.F146F|STIL_uc001cre.1_Silent_p.F146F|STIL_uc001crg.1_Silent_p.F146F	NM_003035	NP_003026	Q15468	STIL_HUMAN	SCL/TAL1 interrupting locus isoform 2	146					cell proliferation|multicellular organismal development	centrosome|cytosol				lung(2)|skin(1)	3		Acute lymphoblastic leukemia(5;0.00116)|all_hematologic(5;0.00444)				AAGCTGAACTGAAGTCATCTA	0.348		NaN											0	0	0	0.139131	0	46	29									
FOXE3	2301	broad.mit.edu	37	1	47882467	47882467	+	Silent	SNP	C	C	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr1:47882467C>T	uc001crk.2	+	1	724	c.480C>T	c.(478-480)TTC>TTT	p.F160F		NM_012186	NP_036318	Q13461	FOXE3_HUMAN	forkhead box E3	160	Fork-head.				cell migration|embryonic organ morphogenesis|enteric nervous system development|hair follicle morphogenesis|hard palate development|lens morphogenesis in camera-type eye|pattern specification process|positive regulation of epithelial cell proliferation|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity|soft palate development|thyroid gland development|thyroid hormone generation	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding				0				READ - Rectum adenocarcinoma(2;0.0908)		ACGGCAGCTTCCTGCGGCGCC	0.542		NaN											0	0	0	0.064281	0	35	21									
INADL	10207	broad.mit.edu	37	1	62263087	62263087	+	Silent	SNP	A	A	G			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr1:62263087A>G	uc001dab.2	+	11	1503	c.1389A>G	c.(1387-1389)CCA>CCG	p.P463P	INADL_uc009waf.1_Silent_p.P463P|INADL_uc001daa.2_Silent_p.P463P|INADL_uc001dad.3_Silent_p.P160P	NM_176877	NP_795352	Q8NI35	INADL_HUMAN	InaD-like	463					intracellular signal transduction|tight junction assembly	apical plasma membrane|perinuclear region of cytoplasm|tight junction	protein binding			ovary(3)|skin(1)	4						CACTTGAACCACCTTCAGACA	0.448		NaN											0	0	0	0.139131	0	122	58									
IL23R	149233	broad.mit.edu	37	1	67666436	67666436	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr1:67666436G>A	uc001ddo.2	+	5	593	c.508G>A	c.(508-510)GAG>AAG	p.E170K	IL23R_uc009waz.2_5'UTR|IL23R_uc001ddp.2_RNA|IL23R_uc010opi.1_RNA|IL23R_uc010opj.1_Intron|IL23R_uc010opk.1_Missense_Mutation_p.E127K|IL23R_uc010opl.1_Intron|IL23R_uc010opm.1_RNA|IL23R_uc001ddq.2_Intron|IL23R_uc010opn.1_Missense_Mutation_p.E15K|IL23R_uc001ddr.2_RNA|IL23R_uc010opo.1_Missense_Mutation_p.E29K|IL23R_uc010opp.1_RNA|IL23R_uc010opq.1_Missense_Mutation_p.E29K|IL23R_uc010opr.1_RNA|IL23R_uc010ops.1_Intron|IL23R_uc010opt.1_5'UTR|IL23R_uc010opu.1_5'UTR|IL23R_uc010opv.1_Missense_Mutation_p.E29K|IL23R_uc010opw.1_Intron|IL23R_uc010opx.1_Intron|IL23R_uc010opy.1_5'UTR|IL23R_uc010opz.1_Intron|IL23R_uc010oqa.1_5'UTR|IL23R_uc010oqb.1_Missense_Mutation_p.E29K|IL23R_uc010oqc.1_Intron|IL23R_uc010oqd.1_Intron|IL23R_uc010oqe.1_Intron|IL23R_uc010oqf.1_Intron|IL23R_uc010oqg.1_5'UTR|IL23R_uc010oqh.1_Intron	NM_144701	NP_653302	Q5VWK5	IL23R_HUMAN	interleukin 23 receptor precursor	170	Extracellular (Potential).|Fibronectin type-III 1.				inflammatory response|negative regulation of interleukin-10 production|positive regulation of defense response to virus by host|positive regulation of interferon-gamma production|positive regulation of interleukin-12 production|positive regulation of memory T cell differentiation|positive regulation of T cell mediated cytotoxicity|positive regulation of T-helper 1 type immune response|positive regulation of T-helper 17 cell lineage commitment|positive regulation of T-helper 17 type immune response|response to interferon-gamma|response to lipopolysaccharide	interleukin-23 receptor complex	receptor activity				0						GACAGAAGAAGAGCAACAGTA	0.289		NaN											0	0	0	0.139131	0	54	29									
IL23R	149233	broad.mit.edu	37	1	67666498	67666498	+	Silent	SNP	G	G	A			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr1:67666498G>A	uc001ddo.2	+	5	655	c.570G>A	c.(568-570)AAG>AAA	p.K190K	IL23R_uc009waz.2_5'UTR|IL23R_uc001ddp.2_RNA|IL23R_uc010opi.1_RNA|IL23R_uc010opj.1_Intron|IL23R_uc010opk.1_Silent_p.K147K|IL23R_uc010opl.1_Intron|IL23R_uc010opm.1_RNA|IL23R_uc001ddq.2_Intron|IL23R_uc010opn.1_Silent_p.K35K|IL23R_uc001ddr.2_RNA|IL23R_uc010opo.1_Silent_p.K49K|IL23R_uc010opp.1_RNA|IL23R_uc010opq.1_Silent_p.K49K|IL23R_uc010opr.1_RNA|IL23R_uc010ops.1_5'UTR|IL23R_uc010opt.1_5'UTR|IL23R_uc010opu.1_5'UTR|IL23R_uc010opv.1_Silent_p.K49K|IL23R_uc010opw.1_Intron|IL23R_uc010opx.1_Intron|IL23R_uc010opy.1_5'UTR|IL23R_uc010opz.1_Intron|IL23R_uc010oqa.1_5'UTR|IL23R_uc010oqb.1_Silent_p.K49K|IL23R_uc010oqc.1_Intron|IL23R_uc010oqd.1_Intron|IL23R_uc010oqe.1_5'UTR|IL23R_uc010oqf.1_5'UTR|IL23R_uc010oqg.1_5'UTR|IL23R_uc010oqh.1_Intron	NM_144701	NP_653302	Q5VWK5	IL23R_HUMAN	interleukin 23 receptor precursor	190	Extracellular (Potential).|Fibronectin type-III 1.				inflammatory response|negative regulation of interleukin-10 production|positive regulation of defense response to virus by host|positive regulation of interferon-gamma production|positive regulation of interleukin-12 production|positive regulation of memory T cell differentiation|positive regulation of T cell mediated cytotoxicity|positive regulation of T-helper 1 type immune response|positive regulation of T-helper 17 cell lineage commitment|positive regulation of T-helper 17 type immune response|response to interferon-gamma|response to lipopolysaccharide	interleukin-23 receptor complex	receptor activity				0						AAGGTGGCAAGAAGTACTTGG	0.373		NaN											0	0	0	0.139131	0	80	44									
FUBP1	8880	broad.mit.edu	37	1	78429366	78429366	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr1:78429366C>T	uc001dii.2	-	13	1165	c.1076G>A	c.(1075-1077)CGA>CAA	p.R359Q	FUBP1_uc001dih.3_RNA|FUBP1_uc010orm.1_Missense_Mutation_p.R380Q	NM_003902	NP_003893	Q96AE4	FUBP1_HUMAN	far upstream element-binding protein	359	Gly-rich.				transcription from RNA polymerase II promoter	nucleus	protein binding|RNA binding|sequence-specific DNA binding transcription factor activity|single-stranded DNA binding			central_nervous_system(2)|lung(1)	3						ACCTCTTCCTCGACCACCAGG	0.428		NaN											0	0	0	0.0918	0	26	41									
COL11A1	1301	broad.mit.edu	37	1	103461433	103461433	+	Missense_Mutation	SNP	G	G	C			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr1:103461433G>C	uc001dul.2	-	28	2645	c.2327C>G	c.(2326-2328)TCT>TGT	p.S776C	COL11A1_uc001duk.2_Translation_Start_Site|COL11A1_uc001dum.2_Missense_Mutation_p.S788C|COL11A1_uc001dun.2_Missense_Mutation_p.S737C|COL11A1_uc009weh.2_Missense_Mutation_p.S660C	NM_001854	NP_001845	P12107	COBA1_HUMAN	alpha 1 type XI collagen isoform A	776	Triple-helical region.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			ovary(6)|breast(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	12		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		TTCACCTTTAGATCCCTTGAG	0.269		NaN											0	0	0	0.055883	0	18	119									
COL11A1	1301	broad.mit.edu	37	1	103468019	103468019	+	Missense_Mutation	SNP	C	C	G			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr1:103468019C>G	uc001dul.2	-	23	2380	c.2062G>C	c.(2062-2064)GGG>CGG	p.G688R	COL11A1_uc001duk.2_5'UTR|COL11A1_uc001dum.2_Missense_Mutation_p.G700R|COL11A1_uc001dun.2_Missense_Mutation_p.G649R|COL11A1_uc009weh.2_Missense_Mutation_p.G572R	NM_001854	NP_001845	P12107	COBA1_HUMAN	alpha 1 type XI collagen isoform A	688	Triple-helical region.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			ovary(6)|breast(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	12		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		CCTGGAGGCCCAGGCTCCCCT	0.423		NaN											0	0	0	0.047766	0	7	7									
ATXN7L2	127002	broad.mit.edu	37	1	110031674	110031674	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr1:110031674C>T	uc001dxr.2	+	7	1004	c.989C>T	c.(988-990)ACC>ATC	p.T330I	ATXN7L2_uc001dxs.2_5'UTR|ATXN7L2_uc001dxt.2_5'Flank	NM_153340	NP_699171	Q5T6C5	AT7L2_HUMAN	ataxin 7-like 2	330										ovary(2)	2		all_epithelial(167;0.00197)|all_lung(203;0.00291)|Lung NSC(277;0.00453)		Colorectal(144;0.0129)|Lung(183;0.0426)|Epithelial(280;0.0675)|READ - Rectum adenocarcinoma(129;0.0693)|all cancers(265;0.071)|LUSC - Lung squamous cell carcinoma(189;0.228)		CCCAGCAGCACCTTCTCTGTT	0.617		NaN											0	0	0	0.139131	0	87	26									
KCNC4	3749	broad.mit.edu	37	1	110766110	110766110	+	Silent	SNP	C	C	T	rs139324520		TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr1:110766110C>T	uc001dzh.2	+	2	1260	c.1203C>T	c.(1201-1203)TAC>TAT	p.Y401Y	KCNC4_uc001dzf.2_Silent_p.Y401Y|KCNC4_uc009wfr.2_Silent_p.Y401Y|KCNC4_uc001dzg.2_Silent_p.Y401Y|KCNC4_uc001dzi.2_RNA	NM_004978	NP_004969	Q03721	KCNC4_HUMAN	Shaw-related voltage-gated potassium channel	401	Helical; Name=Segment S5; (Potential).				synaptic transmission	voltage-gated potassium channel complex	voltage-gated potassium channel activity			large_intestine(1)|ovary(1)|central_nervous_system(1)	3		all_cancers(81;9.88e-06)|all_epithelial(167;3.23e-06)|all_lung(203;0.000116)|Lung NSC(277;0.000233)		Lung(183;0.0238)|all cancers(265;0.0693)|Epithelial(280;0.0748)|Colorectal(144;0.112)|LUSC - Lung squamous cell carcinoma(189;0.135)		TGATCTACTACGCTGAGCGCA	0.592		NaN											0	0	0	0.064281	0	35	120									
PDZK1	5174	broad.mit.edu	37	1	145747150	145747150	+	Missense_Mutation	SNP	G	G	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr1:145747150G>T	uc001eon.1	+	3	204	c.107G>T	c.(106-108)CGG>CTG	p.R36L	NBPF10_uc001emp.3_Intron|PDZK1_uc001eoo.1_Missense_Mutation_p.R36L|PDZK1_uc010oza.1_Missense_Mutation_p.R36L	NM_002614	NP_002605	Q5T2W1	NHRF3_HUMAN	PDZ domain containing 1	36	PDZ 1.				carnitine transport|cell proliferation|drug transport|positive regulation of ion transmembrane transport	brush border membrane|cytoplasm	PDZ domain binding|transporter activity				0	all_hematologic(18;0.00473)|Acute lymphoblastic leukemia(18;0.0786)		KIRC - Kidney renal clear cell carcinoma(6;0.0764)|Kidney(552;0.118)|Colorectal(543;0.229)			CACCTGGTCCGGGTGGTTGAG	0.502		NaN											1	0	1.10923e-09	0.076483	1.16626e-09	22	491									
BCL9	607	broad.mit.edu	37	1	147095710	147095710	+	Silent	SNP	C	C	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr1:147095710C>T	uc001epq.2	+	10	3971	c.3231C>T	c.(3229-3231)CTC>CTT	p.L1077L	BCL9_uc010ozr.1_Silent_p.L991L	NM_004326	NP_004317	O00512	BCL9_HUMAN	B-cell CLL/lymphoma 9	1077	Pro-rich.				Wnt receptor signaling pathway	nucleus	protein binding			ovary(2)|large_intestine(2)|breast(1)|skin(1)	6	all_hematologic(923;0.115)					TGCCAACCCTCAGCCCAATGG	0.493		NaN	T	IGH@|IGL@	B-ALL								0	0	0	0.139131	0	104	219									
KIAA0907	22889	broad.mit.edu	37	1	155887393	155887393	+	Missense_Mutation	SNP	T	T	G			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr1:155887393T>G	uc001fmi.1	-	11	1361	c.1337A>C	c.(1336-1338)CAG>CCG	p.Q446P	KIAA0907_uc001fmj.1_Missense_Mutation_p.Q446P|KIAA0907_uc009wrk.1_Missense_Mutation_p.Q303P|KIAA0907_uc009wrl.1_RNA	NM_014949	NP_055764	Q7Z7F0	K0907_HUMAN	hypothetical protein LOC22889	446	Pro-rich.										0	Hepatocellular(266;0.133)|all_hematologic(923;0.145)|all_neural(408;0.195)		OV - Ovarian serous cystadenocarcinoma(3;8.82e-06)			gggctggggctggggctgggg	0.448		NaN											0	0	0	0.105934	0	7	39									
SH2D2A	9047	broad.mit.edu	37	1	156777073	156777073	+	Missense_Mutation	SNP	T	T	G			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr1:156777073T>G	uc001fqd.2	-	8	1207	c.1067A>C	c.(1066-1068)CAC>CCC	p.H356P	SH2D2A_uc001fqc.1_Missense_Mutation_p.H328P|SH2D2A_uc009wsh.2_Missense_Mutation_p.H366P|SH2D2A_uc001fqe.2_Missense_Mutation_p.H338P|SH2D2A_uc010phs.1_Missense_Mutation_p.H356P	NM_003975	NP_003966	Q9NP31	SH22A_HUMAN	SH2 domain protein 2A isoform 2	356	Pro-rich.				angiogenesis|cell differentiation|signal transduction	cytoplasm|soluble fraction	SH3 domain binding|SH3/SH2 adaptor activity				0	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					TGGGGGCTGGTGGGGCAGGGG	0.597		NaN											0	0	0	0.080935	0	5	22									
SERPINC1	462	broad.mit.edu	37	1	173881128	173881128	+	Missense_Mutation	SNP	C	C	G			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr1:173881128C>G	uc001gjt.2	-	3	552	c.433G>C	c.(433-435)GAG>CAG	p.E145Q		NM_000488	NP_000479	P01008	ANT3_HUMAN	serpin peptidase inhibitor, clade C, member 1	145					blood coagulation|regulation of proteolysis	extracellular space|plasma membrane	heparin binding|protease binding|serine-type endopeptidase inhibitor activity			ovary(1)	1					Enoxaparin(DB01225)|Fondaparinux sodium(DB00569)|Heparin(DB01109)	GATGTTTTCTCAGATATGGTG	0.433		NaN											0	0	0	0.09836	0	43	115									
PPP1R12B	4660	broad.mit.edu	37	1	202549682	202549682	+	Silent	SNP	C	C	G			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr1:202549682C>G	uc001gya.1	+	24	3087	c.2943C>G	c.(2941-2943)TCC>TCG	p.S981S	PPP1R12B_uc001gxz.1_3'UTR|PPP1R12B_uc001gyb.1_3'UTR|PPP1R12B_uc001gyc.1_Silent_p.S207S	NM_002481	NP_002472	O60237	MYPT2_HUMAN	protein phosphatase 1, regulatory (inhibitor)	981					regulation of muscle contraction|signal transduction	cytoplasm	enzyme activator activity			ovary(3)	3			BRCA - Breast invasive adenocarcinoma(75;0.166)			GCAAACTGTCCAAGTAGGCTA	0.478		NaN											0	0	0	0.104719	0	44	28									
ZC3H11A	9877	broad.mit.edu	37	1	203798669	203798669	+	Missense_Mutation	SNP	A	A	G			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr1:203798669A>G	uc001hac.2	+	8	1005	c.389A>G	c.(388-390)AAT>AGT	p.N130S	ZC3H11A_uc001had.2_Missense_Mutation_p.N130S|ZC3H11A_uc001hae.2_Missense_Mutation_p.N130S|ZC3H11A_uc001haf.2_Missense_Mutation_p.N130S|ZC3H11A_uc010pqm.1_Missense_Mutation_p.N76S|ZC3H11A_uc001hag.1_Missense_Mutation_p.N130S	NM_014827	NP_055642	O75152	ZC11A_HUMAN	zinc finger CCCH-type containing 11A	130							nucleic acid binding|protein binding|zinc ion binding			lung(1)|central_nervous_system(1)	2	all_cancers(21;0.0904)|all_epithelial(62;0.234)		BRCA - Breast invasive adenocarcinoma(75;0.109)			GTCCAGTCCAATCCTTCCCCT	0.483		NaN											0	0	0	0.139131	0	121	55									
CENPF	1063	broad.mit.edu	37	1	214825065	214825065	+	Missense_Mutation	SNP	G	G	C			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr1:214825065G>C	uc001hkm.2	+	15	8170	c.7996G>C	c.(7996-7998)GAG>CAG	p.E2666Q		NM_016343	NP_057427	P49454	CENPF_HUMAN	centromere protein F	2762	Potential.|Sufficient for self-association.|Sufficient for centromere localization.				cell differentiation|cell division|cell proliferation|DNA replication|G2 phase of mitotic cell cycle|kinetochore assembly|metaphase plate congression|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|muscle organ development|negative regulation of transcription, DNA-dependent|protein transport|regulation of G2/M transition of mitotic cell cycle|regulation of striated muscle tissue development|response to drug	condensed chromosome outer kinetochore|cytosol|midbody|nuclear envelope|nuclear matrix|perinuclear region of cytoplasm|spindle pole	chromatin binding|dynein binding|protein C-terminus binding|protein homodimerization activity|transcription factor binding			ovary(6)|central_nervous_system(4)|large_intestine(2)|skin(1)	13				all cancers(67;0.00836)|OV - Ovarian serous cystadenocarcinoma(81;0.00855)|GBM - Glioblastoma multiforme(131;0.0694)|Epithelial(68;0.0833)		TCAATTGAAGGAGCTCACACT	0.348		NaN											0	0	0	0.117977	0	46	20									
TMEM63A	9725	broad.mit.edu	37	1	226055673	226055673	+	Silent	SNP	C	C	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr1:226055673C>T	uc001hpm.1	-	7	679	c.429G>A	c.(427-429)CAG>CAA	p.Q143Q	TMEM63A_uc010pvi.1_Silent_p.Q143Q	NM_014698	NP_055513	O94886	TM63A_HUMAN	transmembrane protein 63A	143						integral to membrane|lysosomal membrane	nucleotide binding			ovary(1)|breast(1)	2	Breast(184;0.197)					TGATGTGCCTCTGGAAGGACA	0.542		NaN											0	0	0	0.139131	0	52	46									
ZNF678	339500	broad.mit.edu	37	1	227842637	227842637	+	Missense_Mutation	SNP	G	G	C			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr1:227842637G>C	uc001hqw.1	+	4	1031	c.686G>C	c.(685-687)AGA>ACA	p.R229T	ZNF678_uc009xet.1_Intron|ZNF678_uc009xeu.1_Intron	NM_178549	NP_848644	F5GXA7	F5GXA7_HUMAN	zinc finger protein 678	284					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding			pancreas(1)	1		Prostate(94;0.0885)				CAACATAAGAGAATTCATACT	0.378		NaN											0	0	0	0.086207	0	41	221									
OBSCN	84033	broad.mit.edu	37	1	228399583	228399583	+	Silent	SNP	C	C	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr1:228399583C>T	uc009xez.1	+	2	143	c.99C>T	c.(97-99)ATC>ATT	p.I33I	OBSCN_uc001hsn.2_Silent_p.I33I|uc001hsm.1_Intron	NM_001098623	NP_001092093	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and	33	Ig-like 1.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			stomach(8)|large_intestine(7)|breast(5)|ovary(4)|skin(2)|central_nervous_system(1)|pancreas(1)	28		Prostate(94;0.0405)				GCTGCCAGATCGTGGGTAATC	0.692		NaN											0	0	0	0.02938	0	7	18									
SIPA1L2	57568	broad.mit.edu	37	1	232574863	232574863	+	Missense_Mutation	SNP	G	G	C			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr1:232574863G>C	uc001hvg.2	-	13	4180	c.4022C>G	c.(4021-4023)TCT>TGT	p.S1341C	SIPA1L2_uc001hvf.2_Missense_Mutation_p.S415C	NM_020808	NP_065859	Q9P2F8	SI1L2_HUMAN	signal-induced proliferation-associated 1 like	1341	Ser-rich.				regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			ovary(2)|central_nervous_system(2)|pancreas(1)|skin(1)	6		all_cancers(173;0.00605)|Prostate(94;0.128)|all_epithelial(177;0.186)				CCTGGAATGAGAGGATATCTC	0.582		NaN											0	0	0	0.043863	0	19	76									
LYST	1130	broad.mit.edu	37	1	235969730	235969730	+	Silent	SNP	G	G	C			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr1:235969730G>C	uc001hxj.2	-	6	2881	c.2706C>G	c.(2704-2706)CTC>CTG	p.L902L	LYST_uc009xgb.1_RNA|LYST_uc010pxs.1_RNA|LYST_uc001hxl.1_Silent_p.L902L	NM_000081	NP_000072	Q99698	LYST_HUMAN	lysosomal trafficking regulator	902					defense response to bacterium|defense response to protozoan|defense response to virus|endosome to lysosome transport via multivesicular body sorting pathway|leukocyte chemotaxis|mast cell secretory granule organization|melanosome organization|natural killer cell mediated cytotoxicity|protein transport	cytoplasm|microtubule cytoskeleton	protein binding			ovary(6)|breast(4)|central_nervous_system(2)	12	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.00246)|Prostate(94;0.0771)|Acute lymphoblastic leukemia(190;0.228)	OV - Ovarian serous cystadenocarcinoma(106;0.000674)			AAGCCACACAGAGGAATAGGT	0.438		NaN							Chediak-Higashi_syndrome				0	0	0	0.139131	0	68	187									
RYR2	6262	broad.mit.edu	37	1	237794757	237794757	+	Silent	SNP	G	G	A			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr1:237794757G>A	uc001hyl.1	+	42	6591	c.6471G>A	c.(6469-6471)CAG>CAA	p.Q2157Q		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	2157	Cytoplasmic (By similarity).|4 X approximate repeats.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			TGTTTTACCAGCACCCTAATC	0.448		NaN											0	0	0	0.069456	0	33	28									
ZNF672	79894	broad.mit.edu	37	1	249142042	249142042	+	Missense_Mutation	SNP	C	C	G			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr1:249142042C>G	uc001iex.2	+	4	1264	c.569C>G	c.(568-570)CCC>CGC	p.P190R		NM_024836	NP_079112	Q499Z4	ZN672_HUMAN	zinc finger protein 672	190					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_cancers(71;3.33e-06)|all_epithelial(71;2.41e-06)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.0458)|Lung NSC(105;0.0494)|Melanoma(84;0.199)	all_cancers(173;0.19)	OV - Ovarian serous cystadenocarcinoma(106;0.00805)			TCCCGGAGCCCCACGCGACCC	0.716		NaN											0	0	0	0.02938	0	6	17									
ST8SIA6	338596	broad.mit.edu	37	10	17373460	17373460	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr10:17373460C>T	uc001ipd.2	-	5	469	c.469G>A	c.(469-471)GAA>AAA	p.E157K	ST8SIA6_uc010qce.1_RNA	NM_001004470	NP_001004470	P61647	SIA8F_HUMAN	ST8 alpha-N-acetyl-neuraminide	157	Lumenal (Potential).				post-translational protein modification|protein N-linked glycosylation via asparagine	integral to Golgi membrane	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity			ovary(1)	1						TTTTTGCTTTCCACCTCGTAA	0.393		NaN											0	0	0	0.062417	0	22	63									
MLLT10	8028	broad.mit.edu	37	10	21962602	21962602	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr10:21962602G>A	uc001iqs.2	+	11	1723	c.1375G>A	c.(1375-1377)GAA>AAA	p.E459K	MLLT10_uc001iqt.2_Missense_Mutation_p.E459K|MLLT10_uc001iqv.2_RNA|MLLT10_uc001iqy.2_Missense_Mutation_p.E459K|MLLT10_uc001ira.2_5'UTR|MLLT10_uc001irb.2_RNA|MLLT10_uc001iqz.2_Missense_Mutation_p.E214K	NM_004641	NP_004632	P55197	AF10_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	459	DNA-binding.				positive regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(1)|skin(1)	2						TTCTGGCATAGAAGAAGAAAC	0.398		NaN	T	MLL|PICALM|CDK6	AL								0	0	0	0.139131	0	86	200									
C10orf68	79741	broad.mit.edu	37	10	33000562	33000562	+	Missense_Mutation	SNP	T	T	A			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr10:33000562T>A	uc001iwn.3	+	7	867	c.394T>A	c.(394-396)TCA>ACA	p.S132T	C10orf68_uc001iwl.1_Missense_Mutation_p.S140T|C10orf68_uc001iwm.1_Missense_Mutation_p.S108T|C10orf68_uc010qei.1_Missense_Mutation_p.S59T	NM_024688	NP_078964	Q9H943	CJ068_HUMAN	chromosome 10 open reading frame 68	132										skin(2)|ovary(1)	3						TGATGAAGAATCAGGTGAAAA	0.338		NaN											0	0	0	0.09319	0	11	57									
ANKRD30A	91074	broad.mit.edu	37	10	37508817	37508817	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr10:37508817G>A	uc001iza.1	+	34	4108	c.4009G>A	c.(4009-4011)GAA>AAA	p.E1337K		NM_052997	NP_443723	Q9BXX3	AN30A_HUMAN	ankyrin repeat domain 30A	1393						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(7)|breast(1)|skin(1)	9						AGAGAAAGCAGAAACAGAAGT	0.279		NaN											0	0	0	0.115264	0	2	12									
RET	5979	broad.mit.edu	37	10	43620387	43620387	+	Missense_Mutation	SNP	C	C	A			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr10:43620387C>A	uc001jal.2	+	18	3186	c.2996C>A	c.(2995-2997)GCG>GAG	p.A999E	RET_uc001jak.1_Missense_Mutation_p.A999E|RET_uc010qez.1_Missense_Mutation_p.A745E	NM_020975	NP_066124	P07949	RET_HUMAN	ret proto-oncogene isoform a	999	Protein kinase.|Cytoplasmic (Potential).				homophilic cell adhesion|positive regulation of metanephric glomerulus development|positive regulation of transcription, DNA-dependent|posterior midgut development	integral to membrane	ATP binding|calcium ion binding|transmembrane receptor protein tyrosine kinase activity			thyroid(404)|adrenal_gland(20)|lung(9)|large_intestine(5)|breast(4)|ovary(4)|central_nervous_system(3)|urinary_tract(1)|NS(1)	451		Ovarian(717;0.0423)			Sunitinib(DB01268)	CCGGTGTTTGCGGACATCAGC	0.557		1	T|Mis|N|F	H4|PRKAR1A|NCOA4|PCM1|GOLGA5|TRIM33|KTN1|TRIM27|HOOK3	medullary thyroid| papillary thyroid|pheochromocytoma	medullary thyroid| papillary thyroid|pheochromocytoma	Hirschsprung disease		Multiple_Endocrine_Neoplasia_type_2B|Multiple_Endocrine_Neoplasia_type_2A|Familial_Medullary_Thyroid_Carcinoma				1	0	4.4004e-07	0.083992	4.57955e-07	21	69									
SYT15	83849	broad.mit.edu	37	10	46967428	46967428	+	Nonsense_Mutation	SNP	G	G	A			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr10:46967428G>A	uc001jea.2	-	4	802	c.649C>T	c.(649-651)CAG>TAG	p.Q217*	SYT15_uc001jdz.2_Nonsense_Mutation_p.Q217*|SYT15_uc001jeb.2_Nonsense_Mutation_p.Q95*|SYT15_uc010qfp.1_RNA	NM_031912	NP_114118	Q9BQS2	SYT15_HUMAN	synaptotagmin XV isoform a	217	Cytoplasmic (Potential).|C2 1.					integral to membrane|plasma membrane					0						GGCTGTACCTGAAAGATGAAG	0.602		NaN											0	0	0	0.02938	0	7	67									
MYOZ1	58529	broad.mit.edu	37	10	75391879	75391879	+	Missense_Mutation	SNP	G	G	T	rs149293567		TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr10:75391879G>T	uc001jur.2	-	6	1074	c.709C>A	c.(709-711)CGC>AGC	p.R237S		NM_021245	NP_067068	Q9NP98	MYOZ1_HUMAN	myozenin 1	237					myofibril assembly	nucleus|pseudopodium	FATZ binding			ovary(2)	2	Prostate(51;0.0112)					AAGGTCATGCGTTTGGAGGCC	0.473		NaN											1	0	0.000673444	0.069234	0.000680095	11	60									
TRIM8	81603	broad.mit.edu	37	10	104404923	104404923	+	Missense_Mutation	SNP	G	G	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr10:104404923G>T	uc001kvz.2	+	1	672	c.549G>T	c.(547-549)GAG>GAT	p.E183D		NM_030912	NP_112174	Q9BZR9	TRIM8_HUMAN	tripartite motif-containing 8	183	Potential.					cytoplasm|PML body	ligase activity|protein homodimerization activity|zinc ion binding			ovary(1)	1		Colorectal(252;0.122)		Epithelial(162;3.93e-09)|all cancers(201;1.02e-07)|BRCA - Breast invasive adenocarcinoma(275;0.215)		GCGACGTGGAGATCCGAAGGA	0.587		NaN											1	0	1.33987e-11	0.069234	1.42339e-11	10	11									
C10orf79	80217	broad.mit.edu	37	10	105927390	105927390	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr10:105927390C>T	uc001kxw.2	-	22	2913	c.2797G>A	c.(2797-2799)GAG>AAG	p.E933K	C10orf79_uc009xxq.2_Missense_Mutation_p.E241K|C10orf79_uc001kxx.3_Missense_Mutation_p.E934K	NM_025145	NP_079421	Q8NDM7	WDR96_HUMAN	hypothetical protein LOC80217	933	Potential.										0		Colorectal(252;0.178)		Epithelial(162;4.83e-10)|all cancers(201;2.26e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0194)		TTAAGACACTCTGCTTCAATC	0.358		NaN											0	0	0	0.0333	0	17	40									
DMBT1	1755	broad.mit.edu	37	10	124348677	124348677	+	Missense_Mutation	SNP	T	T	A			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr10:124348677T>A	uc001lgk.1	+	17	2107	c.2001T>A	c.(1999-2001)GAT>GAA	p.D667E	DMBT1_uc001lgl.1_Missense_Mutation_p.D657E|DMBT1_uc001lgm.1_Intron|DMBT1_uc009xzz.1_Missense_Mutation_p.D667E|DMBT1_uc010qtx.1_Intron|DMBT1_uc009yaa.1_Intron	NM_007329	NP_015568	Q9UGM3	DMBT1_HUMAN	deleted in malignant brain tumors 1 isoform b	667	SRCR 5.				epithelial cell differentiation|induction of bacterial agglutination|innate immune response|interspecies interaction between organisms|protein transport|response to virus	extrinsic to membrane|phagocytic vesicle membrane|zymogen granule membrane	calcium-dependent protein binding|Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|pattern recognition receptor activity|scavenger receptor activity|zymogen binding			central_nervous_system(7)	7		all_neural(114;0.0765)|Lung NSC(174;0.132)|all_lung(145;0.163)|Breast(234;0.238)				TTGTCCTGGATGATGTGCGCT	0.587		NaN											0	0	0	0.139131	0	110	94									
DMBT1	1755	broad.mit.edu	37	10	124402857	124402857	+	Silent	SNP	C	C	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr10:124402857C>T	uc001lgk.1	+	53	7291	c.7185C>T	c.(7183-7185)GTC>GTT	p.V2395V	DMBT1_uc001lgl.1_Silent_p.V2385V|DMBT1_uc001lgm.1_Silent_p.V1767V|DMBT1_uc009xzz.1_Silent_p.V2394V|DMBT1_uc010qtx.1_Silent_p.V1115V|DMBT1_uc009yab.1_Silent_p.V1098V|DMBT1_uc009yac.1_Silent_p.V689V	NM_007329	NP_015568	Q9UGM3	DMBT1_HUMAN	deleted in malignant brain tumors 1 isoform b	2395					epithelial cell differentiation|induction of bacterial agglutination|innate immune response|interspecies interaction between organisms|protein transport|response to virus	extrinsic to membrane|phagocytic vesicle membrane|zymogen granule membrane	calcium-dependent protein binding|Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|pattern recognition receptor activity|scavenger receptor activity|zymogen binding			central_nervous_system(7)	7		all_neural(114;0.0765)|Lung NSC(174;0.132)|all_lung(145;0.163)|Breast(234;0.238)				AGGTGGACGTCGTCCTGGGTC	0.647		NaN											0	0	0	0.0333	0	17	41									
TCERG1L	256536	broad.mit.edu	37	10	132891546	132891546	+	Missense_Mutation	SNP	C	C	A			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr10:132891546C>A	uc001lkp.2	-	12	1726	c.1640G>T	c.(1639-1641)CGG>CTG	p.R547L		NM_174937	NP_777597	Q5VWI1	TCRGL_HUMAN	transcription elongation regulator 1-like	547	FF 2.									large_intestine(2)|ovary(2)	4		all_cancers(35;1.22e-10)|all_epithelial(44;2.65e-09)|Lung NSC(174;0.00188)|all_lung(145;0.00307)|Melanoma(40;0.0179)|all_neural(114;0.0424)|Breast(234;0.0743)|Colorectal(57;0.09)		all cancers(32;0.000899)|OV - Ovarian serous cystadenocarcinoma(35;0.0021)|Epithelial(32;0.00276)		CCTCTGATCCCGGCCGTATTT	0.443		NaN											1	0	0.000157383	0.038147	0.000160124	8	96									
LSP1	4046	broad.mit.edu	37	11	1905742	1905742	+	Missense_Mutation	SNP	G	G	C			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr11:1905742G>C	uc001lui.2	+	7	823	c.648G>C	c.(646-648)AAG>AAC	p.K216N	LSP1_uc001luj.2_Missense_Mutation_p.K344N|LSP1_uc001luk.2_Missense_Mutation_p.K154N|LSP1_uc001lul.2_Missense_Mutation_p.K154N|LSP1_uc001lum.2_Missense_Mutation_p.K154N	NM_002339	NP_002330	P33241	LSP1_HUMAN	lymphocyte-specific protein 1 isoform 1	216					cellular component movement|cellular defense response	actin cytoskeleton|Golgi apparatus|plasma membrane	actin binding|signal transducer activity			large_intestine(1)	1		all_epithelial(84;0.000138)|Breast(177;0.000962)|Ovarian(85;0.0014)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00147)|Lung(200;0.0729)|LUSC - Lung squamous cell carcinoma(625;0.0856)		ACAGTGTGAAGAAATCCCAGC	0.572		NaN											0	0	0	0.105934	0	14	43									
SPON1	10418	broad.mit.edu	37	11	14276159	14276159	+	Missense_Mutation	SNP	T	T	A			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr11:14276159T>A	uc001mle.2	+	9	1514	c.976T>A	c.(976-978)TGG>AGG	p.W326R		NM_006108	NP_006099	Q9HCB6	SPON1_HUMAN	spondin 1, extracellular matrix protein	326	Spondin.				cell adhesion	extracellular space|proteinaceous extracellular matrix	protein binding				0				Epithelial(150;0.00898)		TAGTCCCGACTGGAACGTAGG	0.542		NaN											0	0	0	0.132662	0	14	42									
LDLRAD3	143458	broad.mit.edu	37	11	36248840	36248840	+	Silent	SNP	G	G	A			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr11:36248840G>A	uc001mwk.1	+	5	697	c.660G>A	c.(658-660)CTG>CTA	p.L220L	LDLRAD3_uc010rey.1_Silent_p.L171L|LDLRAD3_uc010rez.1_Silent_p.L99L|LDLRAD3_uc010rfa.1_Intron	NM_174902	NP_777562	Q86YD5	LRAD3_HUMAN	low density lipoprotein receptor class A domain	220	Cytoplasmic (Potential).					integral to membrane	receptor activity			central_nervous_system(1)	1	all_lung(20;0.089)|Lung NSC(22;0.175)|all_epithelial(35;0.177)	all_hematologic(20;0.124)				TGTCCCGCCTGGTGGTCCTGG	0.627		NaN											0	0	0	0.045705	0	34	41									
OR5D13	390142	broad.mit.edu	37	11	55541543	55541543	+	Silent	SNP	G	G	A			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr11:55541543G>A	uc010ril.1	+	1	630	c.630G>A	c.(628-630)GTG>GTA	p.V210V		NM_001001967	NP_001001967	Q8NGL4	OR5DD_HUMAN	olfactory receptor, family 5, subfamily D,	210	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|pancreas(1)|skin(1)	3		all_epithelial(135;0.196)				TCAATGAGGTGAGCAGCCTAA	0.403		NaN											0	0	0	0.069288	0	24	124									
GIF	2694	broad.mit.edu	37	11	59609985	59609985	+	Missense_Mutation	SNP	C	C	G			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr11:59609985C>G	uc001noi.2	-	4	490	c.442G>C	c.(442-444)GAG>CAG	p.E148Q	GIF_uc010rkz.1_3'UTR	NM_005142	NP_005133	P27352	IF_HUMAN	gastric intrinsic factor (vitamin B synthesis)	148					cobalamin metabolic process|cobalamin transport|cobalt ion transport	apical plasma membrane|endosome|extracellular space|microvillus	cobalamin binding			ovary(1)|liver(1)	2						AAGGTCGCCTCAGAGTTCTTC	0.577		NaN											0	0	0	0.055883	0	22	61									
SLC22A25	387601	broad.mit.edu	37	11	62951183	62951183	+	Missense_Mutation	SNP	C	C	G			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr11:62951183C>G	uc001nwr.1	-	5	937	c.937G>C	c.(937-939)GAC>CAC	p.D313H	SLC22A10_uc010rmo.1_Intron|SLC22A25_uc009yoq.1_RNA|SLC22A25_uc001nws.1_RNA|SLC22A25_uc001nwt.1_Missense_Mutation_p.D313H	NM_199352	NP_955384	Q6T423	S22AP_HUMAN	putative UST1-like organic anion transporter	313	Cytoplasmic (Potential).				transmembrane transport	integral to membrane				ovary(3)|skin(1)	4						GTTAGGATGTCTTCAGCATTC	0.438		NaN											0	0	0	0.139131	0	94	173									
SF1	7536	broad.mit.edu	37	11	64544068	64544068	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr11:64544068C>T	uc001obb.1	-	2	439	c.62G>A	c.(61-63)CGC>CAC	p.R21H	SF1_uc010rnn.1_5'UTR|SF1_uc001oaz.1_Missense_Mutation_p.R146H|SF1_uc001oba.1_Missense_Mutation_p.R21H|SF1_uc001obc.1_Missense_Mutation_p.R21H|SF1_uc001obd.1_Missense_Mutation_p.R21H|SF1_uc001obe.1_5'UTR|SF1_uc010rno.1_5'UTR|SF1_uc001obf.2_Missense_Mutation_p.R21H	NM_004630	NP_004621	Q15637	SF01_HUMAN	splicing factor 1 isoform 1	21				R->K: No effect.|R->A: Decreases interaction with U2AF2 and spliceosome assembly.	nuclear mRNA 3'-splice site recognition|regulation of transcription, DNA-dependent|transcription, DNA-dependent	ribosome|spliceosomal complex	protein binding|RNA binding|transcription corepressor activity|zinc ion binding			ovary(1)|breast(1)|skin(1)	3						TTGGTTCCAGCGGCTCCTCTT	0.428		NaN											0	0	0	0.09836	0	41	71									
ADRBK1	156	broad.mit.edu	37	11	67051208	67051208	+	Silent	SNP	C	C	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr11:67051208C>T	uc009yrn.1	+	16	1625	c.1359C>T	c.(1357-1359)TTC>TTT	p.F453F	ADRBK1_uc009yrm.1_Intron	NM_001619	NP_001610	P25098	ARBK1_HUMAN	beta-adrenergic receptor kinase 1	453	Protein kinase.				activation of phospholipase C activity|cardiac muscle contraction|desensitization of G-protein coupled receptor protein signaling pathway|muscarinic acetylcholine receptor signaling pathway|negative regulation of striated muscle contraction|negative regulation of the force of heart contraction by chemical signal|nerve growth factor receptor signaling pathway|peptidyl-serine phosphorylation|positive regulation of catecholamine secretion|tachykinin receptor signaling pathway	cytosol|soluble fraction	alpha-2A adrenergic receptor binding|ATP binding|beta-adrenergic receptor kinase activity|Edg-2 lysophosphatidic acid receptor binding|G-protein coupled receptor kinase activity|signal transducer activity			large_intestine(1)	1			BRCA - Breast invasive adenocarcinoma(15;2.26e-06)		Adenosine triphosphate(DB00171)	GCCCCTTTTTCCGCTCCCTGG	0.542		NaN											0	0	0	0.049695	0	20	80									
ANKRD13D	338692	broad.mit.edu	37	11	67068616	67068616	+	Missense_Mutation	SNP	T	T	C			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr11:67068616T>C	uc001okc.1	+	12	1479	c.968T>C	c.(967-969)ATT>ACT	p.I323T	ANKRD13D_uc001okd.1_Missense_Mutation_p.I410T|ANKRD13D_uc001oke.1_Missense_Mutation_p.I323T|ANKRD13D_uc001okg.1_Missense_Mutation_p.I106T|ANKRD13D_uc001okh.1_Missense_Mutation_p.I106T|ANKRD13D_uc001oki.1_Missense_Mutation_p.I60T|SSH3_uc001okj.2_5'Flank|SSH3_uc001okk.2_5'Flank|SSH3_uc001okl.2_5'Flank	NM_207354	NP_997237	Q6ZTN6	AN13D_HUMAN	ankyrin repeat domain 13 family, member D	323										ovary(1)	1			BRCA - Breast invasive adenocarcinoma(15;2.26e-06)			CCCGTCAAAATTGGTGAGAGG	0.632		NaN											0	0	0	0.058154	0	10	35									
AQP11	282679	broad.mit.edu	37	11	77301521	77301521	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr11:77301521G>A	uc001oyj.2	+	1	842	c.484G>A	c.(484-486)GAC>AAC	p.D162N	AQP11_uc009yuu.2_Intron	NM_173039	NP_766627	Q8NBQ7	AQP11_HUMAN	aquaporin 11	162						cell surface|integral to membrane	transporter activity				0	all_cancers(14;1.75e-17)|all_epithelial(13;4.7e-20)|Ovarian(111;0.249)		Epithelial(5;4.73e-49)|BRCA - Breast invasive adenocarcinoma(5;1.4e-30)			CATCCGAGTCGACTTGCTCAA	0.567		NaN											0	0	0	0.050027	0	35	76									
DYNC2H1	79659	broad.mit.edu	37	11	103049829	103049829	+	Missense_Mutation	SNP	G	G	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr11:103049829G>T	uc001pho.2	+	39	6358	c.6214G>T	c.(6214-6216)GAT>TAT	p.D2072Y	DYNC2H1_uc001phn.1_Missense_Mutation_p.D2072Y|DYNC2H1_uc009yxe.1_Intron	NM_001080463	NP_001073932	Q8NCM8	DYHC2_HUMAN	dynein, cytoplasmic 2, heavy chain 1	2072	AAA 2 (By similarity).				cell projection organization|Golgi organization|microtubule-based movement|multicellular organismal development	cilium axoneme|dynein complex|Golgi apparatus|microtubule|plasma membrane	ATP binding|ATPase activity|microtubule motor activity				0		Acute lymphoblastic leukemia(157;0.000966)|all_hematologic(158;0.00348)		BRCA - Breast invasive adenocarcinoma(274;0.000177)|Epithelial(105;0.0785)		TGTTCTGGATGATAATCGACT	0.388		NaN											1	0	5.50884e-06	0.09319	5.66109e-06	12	44									
HTR3A	3359	broad.mit.edu	37	11	113856847	113856847	+	Missense_Mutation	SNP	C	C	T	rs139246177		TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr11:113856847C>T	uc010rxb.1	+	6	906	c.673C>T	c.(673-675)CGG>TGG	p.R225W	HTR3A_uc010rxa.1_Missense_Mutation_p.R225W|HTR3A_uc009yyx.2_Intron|HTR3A_uc010rxc.1_Missense_Mutation_p.R204W	NM_213621	NP_998786	P46098	5HT3A_HUMAN	5-hydroxytryptamine (serotonin) receptor 3A	219	Extracellular (Potential).				digestion|synaptic transmission	cell junction|integral to plasma membrane|postsynaptic membrane	serotonin binding|serotonin receptor activity|serotonin-activated cation-selective channel activity				0		all_cancers(61;2.31e-17)|all_epithelial(67;2.1e-10)|all_hematologic(158;4.64e-05)|Melanoma(852;0.000312)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0101)|all_neural(223;0.0281)|Prostate(24;0.0294)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;2.71e-06)|Epithelial(105;2.58e-05)|all cancers(92;0.000238)|OV - Ovarian serous cystadenocarcinoma(223;0.191)	Alosetron(DB00969)|Chloroprocaine(DB01161)|Cisapride(DB00604)|Dolasetron(DB00757)|Granisetron(DB00889)|Mirtazapine(DB00370)|Ondansetron(DB00904)|Palonosetron(DB00377)|Procaine(DB00721)|Tubocurarine(DB01199)	GCCCTACTTTCGGGAGTTCAG	0.478		NaN											0	0	0	0.139131	0	53	131									
DDX6	1656	broad.mit.edu	37	11	118625512	118625512	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr11:118625512C>T	uc001pub.2	-	13	1722	c.1361G>A	c.(1360-1362)GGA>GAA	p.G454E	DDX6_uc001pua.2_Missense_Mutation_p.G154E|DDX6_uc001puc.2_Missense_Mutation_p.G454E	NM_004397	NP_004388	P26196	DDX6_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 6	454	Helicase C-terminal.				exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	cytoplasmic mRNA processing body|cytosol|RNA-induced silencing complex|stress granule	ATP binding|ATP-dependent helicase activity|protein binding|RNA binding|RNA helicase activity			ovary(1)	1	all_hematologic(175;0.0839)	Renal(330;0.0183)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)|Hepatocellular(160;0.0893)|Breast(348;0.0979)|all_hematologic(192;0.103)		OV - Ovarian serous cystadenocarcinoma(223;3.39e-06)|BRCA - Breast invasive adenocarcinoma(274;3.4e-05)|Colorectal(284;0.0377)		AATTTCTGTTCCCAGCTGCTC	0.423		NaN	T	IGH@	B-NHL								0	0	0	0.134883	0	31	55									
BCL9L	283149	broad.mit.edu	37	11	118779098	118779098	+	Missense_Mutation	SNP	T	T	C			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr11:118779098T>C	uc001pug.2	-	2	1258	c.293A>G	c.(292-294)CAG>CGG	p.Q98R	BCL9L_uc009zal.2_Missense_Mutation_p.Q93R	NM_182557	NP_872363	Q86UU0	BCL9L_HUMAN	B-cell CLL/lymphoma 9-like	98					negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of epithelial to mesenchymal transition|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		transcription coactivator activity			ovary(1)|pancreas(1)	2	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0425)|all_hematologic(192;0.103)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.66e-05)		CACCCCTGCCTGGGGGTTCTT	0.647		NaN											0	0	0	0.116897	0	28	42									
ETS1	2113	broad.mit.edu	37	11	128354726	128354726	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr11:128354726G>A	uc010sbs.1	-	5	1038	c.722C>T	c.(721-723)ACC>ATC	p.T241I	ETS1_uc001qej.2_Missense_Mutation_p.T285I|ETS1_uc009zch.2_Intron|ETS1_uc009zcg.2_Missense_Mutation_p.T241I	NM_005238	NP_005229	P14921	ETS1_HUMAN	v-ets erythroblastosis virus E26 oncogene	241				MCMGRTSR -> FLPPPLPP (in Ref. 6; AAA52409).	cell motility|immune response|induction of apoptosis|negative regulation of cell cycle|negative regulation of cell cycle|negative regulation of cell proliferation|PML body organization|positive regulation of cellular component movement|positive regulation of erythrocyte differentiation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|response to antibiotic|transcription from RNA polymerase II promoter	nucleus|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|sequence-specific DNA binding transcription factor activity|transcription factor binding			lung(4)|central_nervous_system(1)|pleura(1)	6	all_hematologic(175;0.0537)	Lung NSC(97;0.000542)|all_lung(97;0.000665)|Breast(109;0.00765)|all_neural(223;0.0351)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;1.47e-05)|OV - Ovarian serous cystadenocarcinoma(99;0.0174)|LUSC - Lung squamous cell carcinoma(976;0.0815)|Lung(307;0.0833)		ACCACGACTGGTCCTCCCCAT	0.418		NaN											0	0	0	0.076483	0	21	63									
LEPREL2	10536	broad.mit.edu	37	12	6948245	6948245	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr12:6948245C>T	uc001qra.1	+	16	2021	c.1987C>T	c.(1987-1989)CGG>TGG	p.R663W	LEPREL2_uc001qqz.1_Missense_Mutation_p.R470W|LEPREL2_uc001qrb.1_Missense_Mutation_p.R470W|GNB3_uc001qrc.2_5'Flank|GNB3_uc001qrd.2_5'Flank|GNB3_uc009zfe.2_5'Flank	NM_014262	NP_055077	Q8IVL6	P3H3_HUMAN	leprecan-like 2 precursor	663	Fe2OG dioxygenase.				negative regulation of cell proliferation	endoplasmic reticulum	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-proline 3-dioxygenase activity				0					L-Proline(DB00172)|Succinic acid(DB00139)|Vitamin C(DB00126)	GGCCGTGACTCGGGGACGGCG	0.677		NaN											0	0	0	0.021553	0	6	25									
TAS2R20	259295	broad.mit.edu	37	12	11150218	11150218	+	Missense_Mutation	SNP	T	T	A			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr12:11150218T>A	uc001qzm.2	-	1	257	c.257A>T	c.(256-258)AAT>ATT	p.N86I	PRR4_uc009zhp.2_Intron|PRH1_uc001qzb.3_Intron|PRH1_uc001qzc.2_Intron|PRB4_uc001qzf.1_Intron|PRH1_uc001qzj.2_Intron	NM_176889	NP_795370	P59543	T2R20_HUMAN	taste receptor, type 2, member 20	86	Helical; Name=3; (Potential).				sensory perception of taste	integral to membrane	G-protein coupled receptor activity				0						TGCCCAGGCATTAGAAATAAA	0.343		NaN											0	0	0	0.139131	0	62	56									
PLEKHA5	54477	broad.mit.edu	37	12	19406895	19406895	+	Silent	SNP	C	C	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr12:19406895C>T	uc001reb.2	+	4	335	c.249C>T	c.(247-249)ACC>ACT	p.T83T	PLEKHA5_uc010sie.1_Silent_p.T83T|PLEKHA5_uc001rea.2_Silent_p.T83T|PLEKHA5_uc009zin.2_5'UTR|PLEKHA5_uc010sif.1_5'UTR|PLEKHA5_uc010sig.1_5'UTR|PLEKHA5_uc010sih.1_5'UTR	NM_019012	NP_061885	Q9HAU0	PKHA5_HUMAN	pleckstrin homology domain containing, family A	83	WW 2.						1-phosphatidylinositol binding|protein binding			ovary(1)|kidney(1)|skin(1)	3	Acute lymphoblastic leukemia(4;0.000455)|all_hematologic(4;0.00804)					GGAAAGTGACCTGCAAACATC	0.323		NaN											0	0	0	0.139131	0	109	79									
C12orf71	728858	broad.mit.edu	37	12	27235288	27235288	+	Silent	SNP	A	A	G			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr12:27235288A>G	uc001rhq.2	-	1	168	c.129T>C	c.(127-129)GAT>GAC	p.D43D		NM_001080406	NP_001073875	A8MTZ7	CL071_HUMAN	hypothetical protein LOC728858	43											0						TGGAAGGTGCATCTTCCCAGG	0.547		NaN											0	0	0	0.058154	0	9	43									
DDX11	1663	broad.mit.edu	37	12	31237922	31237922	+	Missense_Mutation	SNP	G	G	C			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr12:31237922G>C	uc001rjt.1	+	5	751	c.500G>C	c.(499-501)AGA>ACA	p.R167T	DDX11_uc010sjw.1_Missense_Mutation_p.R167T|DDX11_uc010sjx.1_RNA|DDX11_uc001rjr.1_Missense_Mutation_p.R167T|DDX11_uc001rjs.1_Missense_Mutation_p.R167T|DDX11_uc001rju.1_5'UTR|DDX11_uc001rjv.1_Missense_Mutation_p.R167T|DDX11_uc001rjw.1_Missense_Mutation_p.R141T|DDX11_uc001rjx.1_5'Flank	NM_152438	NP_689651	Q96FC9	DDX11_HUMAN	DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 11	167	Glu-rich.|Helicase ATP-binding.				G2/M transition of mitotic cell cycle|interspecies interaction between organisms|mitotic sister chromatid segregation|positive regulation of cell proliferation|S phase of mitotic cell cycle|sister chromatid cohesion	midbody|nuclear chromatin|nucleolus|spindle pole	ATP binding|ATP-dependent DNA helicase activity|DNA binding|protein binding|RNA binding			breast(3)	3	all_cancers(9;1.77e-11)|all_lung(12;6.21e-11)|all_epithelial(9;6.49e-11)|Lung NSC(12;1.06e-08)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0429)|Lung SC(12;0.0592)|Esophageal squamous(101;0.233)					GAAGAAGAAAGAGAGAATCTC	0.612		NaN								Multiple Myeloma(12;0.14)			0	0	0	0.009096	0	3	14									
NELL2	4753	broad.mit.edu	37	12	45173749	45173749	+	Nonsense_Mutation	SNP	G	G	C			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr12:45173749G>C	uc001rog.2	-	4	987	c.392C>G	c.(391-393)TCA>TGA	p.S131*	NELL2_uc001rof.3_Nonsense_Mutation_p.S130*|NELL2_uc001roh.2_Nonsense_Mutation_p.S131*|NELL2_uc009zkd.2_Nonsense_Mutation_p.S130*|NELL2_uc010skz.1_Nonsense_Mutation_p.S181*|NELL2_uc010sla.1_Nonsense_Mutation_p.S154*|NELL2_uc001roi.1_Nonsense_Mutation_p.S131*|NELL2_uc010slb.1_Nonsense_Mutation_p.S130*|NELL2_uc001roj.2_Nonsense_Mutation_p.S131*	NM_001145108	NP_001138580	Q99435	NELL2_HUMAN	NEL-like protein 2 isoform b precursor	131	TSP N-terminal.				cell adhesion	extracellular region	calcium ion binding|protein binding|structural molecule activity			skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	4	Lung SC(27;0.192)	Lung NSC(34;0.144)		GBM - Glioblastoma multiforme(48;0.092)		GTGACTGCCTGAGCGGTAATG	0.468		NaN											0	0	0	0.116897	0	28	132									
PLEKHA9	51054	broad.mit.edu	37	12	45567959	45567959	+	Missense_Mutation	SNP	C	C	G			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr12:45567959C>G	uc001rom.1	-	3	727	c.190G>C	c.(190-192)GAG>CAG	p.E64Q	PLEKHA9_uc009zke.2_Missense_Mutation_p.E64Q	NM_015899	NP_056983			pleckstrin homology domain containing, family A												0	Lung SC(27;0.192)|Renal(347;0.236)			GBM - Glioblastoma multiforme(48;0.173)		TAGAGCAGCTCAGAGGTGAAG	0.443		NaN											0	0	0	0.139131	0	50	154									
AQP6	363	broad.mit.edu	37	12	50368531	50368531	+	Silent	SNP	C	C	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr12:50368531C>T	uc001rvr.1	+	3	901	c.564C>T	c.(562-564)ATC>ATT	p.I188I	AQP6_uc001rvp.1_Silent_p.I14I|AQP6_uc001rvq.1_RNA	NM_001652	NP_001643	Q13520	AQP6_HUMAN	aquaporin 6	188	Helical; (Potential).				excretion|odontogenesis	integral to plasma membrane|transport vesicle membrane	anion channel activity|water channel activity				0						CTCCCCAGATCCACTTCACTG	0.607		NaN									OREG0021809	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.059317	0	33	21									
RACGAP1	29127	broad.mit.edu	37	12	50390835	50390835	+	Silent	SNP	G	G	C			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr12:50390835G>C	uc001rvt.2	-	12	1342	c.1032C>G	c.(1030-1032)GTC>GTG	p.V344V	RACGAP1_uc009zlm.1_Silent_p.V344V|RACGAP1_uc001rvs.2_Silent_p.V344V|RACGAP1_uc001rvu.2_Silent_p.V344V	NM_013277	NP_037409	Q9H0H5	RGAP1_HUMAN	Rac GTPase activating protein 1	344					blood coagulation|cytokinesis, actomyosin contractile ring assembly|cytokinesis, initiation of separation|embryo development|microtubule-based movement|neuroblast proliferation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction|spermatogenesis|sulfate transport	acrosomal vesicle|cytosol|microtubule|midbody|nucleus|spindle	alpha-tubulin binding|beta-tubulin binding|gamma-tubulin binding|GTPase activator activity|metal ion binding			kidney(1)	1						CTCCAATCTTGACAGGTGTTC	0.443		NaN											0	0	0	0.069288	0	22	78									
DNAJC14	85406	broad.mit.edu	37	12	56216185	56216185	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr12:56216185G>A	uc001shx.1	-	6	2074	c.1870C>T	c.(1870-1872)CGG>TGG	p.R624W	DNAJC14_uc001shu.1_Missense_Mutation_p.R624W|DNAJC14_uc009zob.1_Missense_Mutation_p.R624W	NM_032364	NP_115740	Q6Y2X3	DJC14_HUMAN	dopamine receptor interacting protein	624					protein folding|protein transport	endoplasmic reticulum membrane|integral to membrane	heat shock protein binding|unfolded protein binding			ovary(3)|large_intestine(1)	4						CCTGGAATCCGAGAACCAAAT	0.453		NaN									OREG0021910	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.0918	0	23	87									
IKZF4	64375	broad.mit.edu	37	12	56427078	56427078	+	Nonsense_Mutation	SNP	A	A	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr12:56427078A>T	uc001sjb.1	+	8	1129	c.970A>T	c.(970-972)AAG>TAG	p.K324*	IKZF4_uc010sqa.1_Nonsense_Mutation_p.K277*|IKZF4_uc001sjc.1_Nonsense_Mutation_p.K324*|IKZF4_uc001sjd.1_Nonsense_Mutation_p.K222*|IKZF4_uc009zoi.1_Nonsense_Mutation_p.K279*|IKZF4_uc001sje.1_Nonsense_Mutation_p.K283*	NM_022465	NP_071910	Q9H2S9	IKZF4_HUMAN	zinc finger protein, subfamily 1A, 4	324					negative regulation of transcription, DNA-dependent	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1			UCEC - Uterine corpus endometrioid carcinoma (6;0.025)|OV - Ovarian serous cystadenocarcinoma(18;0.123)			CACCAAACGCAAGCGTTCCAC	0.502		NaN											0	0	0	0.144211	0	26	247									
OS9	10956	broad.mit.edu	37	12	58110272	58110272	+	Missense_Mutation	SNP	G	G	C			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr12:58110272G>C	uc001spj.2	+	8	1029	c.970G>C	c.(970-972)GGA>CGA	p.G324R	OS9_uc010srx.1_Intron|OS9_uc001spk.2_Missense_Mutation_p.G324R|OS9_uc001spl.2_Missense_Mutation_p.G324R|OS9_uc001spm.2_Missense_Mutation_p.G324R|OS9_uc001spn.2_Missense_Mutation_p.G325R|OS9_uc010sry.1_Missense_Mutation_p.G292R|OS9_uc010srz.1_Missense_Mutation_p.G265R	NM_006812	NP_006803	Q13438	OS9_HUMAN	osteosarcoma amplified 9, endoplasmic reticulum	324					ER-associated protein catabolic process|protein retention in ER lumen|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to endoplasmic reticulum stress	endoplasmic reticulum lumen|Hrd1p ubiquitin ligase complex	glycoprotein binding|protein binding|sugar binding			ovary(1)	1	all_neural(12;0.00548)|Glioma(12;0.0126)|Melanoma(17;0.122)		BRCA - Breast invasive adenocarcinoma(9;0.109)			CCAGGCCCCAGGAGGGGAGGA	0.597		NaN											0	0	0	0.115264	0	2	6									
APPL2	55198	broad.mit.edu	37	12	105593247	105593247	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr12:105593247G>A	uc001tlf.1	-	10	985	c.767C>T	c.(766-768)TCT>TTT	p.S256F	APPL2_uc010swt.1_Missense_Mutation_p.S213F|APPL2_uc001tlg.1_Missense_Mutation_p.S10F|APPL2_uc010swu.1_Missense_Mutation_p.S262F|APPL2_uc009zuq.2_Missense_Mutation_p.S213F	NM_018171	NP_060641	Q8NEU8	DP13B_HUMAN	adaptor protein, phosphotyrosine interaction, PH	256	Required for RAB5A binding (By similarity).				cell cycle|cell proliferation|signal transduction	early endosome membrane|nucleus	protein binding			upper_aerodigestive_tract(1)	1						TTCATCAACAGAAAGTAATTC	0.473		NaN											0	0	0	0.092188	0	40	29									
POLR3B	55703	broad.mit.edu	37	12	106820975	106820975	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr12:106820975C>T	uc001tlp.2	+	13	1324	c.1102C>T	c.(1102-1104)CTT>TTT	p.L368F	POLR3B_uc001tlq.2_Missense_Mutation_p.L310F	NM_018082	NP_060552	Q9NW08	RPC2_HUMAN	DNA-directed RNA polymerase III B isoform 1	368					innate immune response|positive regulation of innate immune response|positive regulation of interferon-beta production|response to virus|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase III promoter	nucleoplasm	DNA binding|DNA-directed RNA polymerase activity|metal ion binding|ribonucleoside binding			ovary(1)|central_nervous_system(1)	2						TTTTTTTTAGCTTTTATCTCT	0.274		NaN											0	0	0	0.021553	0	4	9									
ACACB	32	broad.mit.edu	37	12	109702055	109702055	+	Missense_Mutation	SNP	A	A	G			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr12:109702055A>G	uc001tob.2	+	50	6925	c.6806A>G	c.(6805-6807)GAC>GGC	p.D2269G	ACACB_uc001toc.2_Missense_Mutation_p.D2269G|ACACB_uc010sxl.1_RNA|ACACB_uc001tod.2_RNA|ACACB_uc010sxm.1_Missense_Mutation_p.D935G	NM_001093	NP_001084	O00763	ACACB_HUMAN	acetyl-Coenzyme A carboxylase beta	2269	Carboxyltransferase.				acetyl-CoA metabolic process|carnitine shuttle|energy reserve metabolic process|fatty acid biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|regulation of fatty acid oxidation	cytosol|endomembrane system|Golgi apparatus|membrane	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			ovary(5)|upper_aerodigestive_tract(1)|pancreas(1)|skin(1)	8					Biotin(DB00121)	GATCTCTCCGACAAGGACCGA	0.552		NaN									OREG0022102	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.059317	0	33	123									
UBE3B	89910	broad.mit.edu	37	12	109939197	109939197	+	Silent	SNP	G	G	A			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr12:109939197G>A	uc001top.2	+	13	1743	c.1140G>A	c.(1138-1140)TTG>TTA	p.L380L	UBE3B_uc001toq.2_Silent_p.L380L|UBE3B_uc001too.1_RNA|UBE3B_uc009zvj.1_Silent_p.L380L	NM_130466	NP_569733	Q7Z3V4	UBE3B_HUMAN	ubiquitin protein ligase E3B	380					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	intracellular	ubiquitin-protein ligase activity			ovary(2)|lung(2)	4						CAATGCACTTGATCACCAAAC	0.557		NaN											0	0	0	0.139131	0	111	76									
KNTC1	9735	broad.mit.edu	37	12	123024233	123024233	+	Missense_Mutation	SNP	A	A	G			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr12:123024233A>G	uc001ucv.2	+	5	540	c.377A>G	c.(376-378)CAG>CGG	p.Q126R	KNTC1_uc010taf.1_Missense_Mutation_p.Q126R	NM_014708	NP_055523	P50748	KNTC1_HUMAN	Rough Deal homolog, centromere/kinetochore	126					cell division|mitotic cell cycle checkpoint|mitotic prometaphase|protein complex assembly|regulation of exit from mitosis	condensed chromosome kinetochore|cytosol|kinetochore microtubule|nucleus|spindle pole	protein binding			ovary(5)|kidney(3)|lung(1)|central_nervous_system(1)	10	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;7.21e-05)|Epithelial(86;0.000178)|BRCA - Breast invasive adenocarcinoma(302;0.217)		GCATTTGTTCAGAAAGCTAAC	0.264		NaN											0	0	0	0.115264	0	3	1									
EP400	57634	broad.mit.edu	37	12	132502842	132502842	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr12:132502842C>T	uc001ujn.2	+	20	4233	c.4198C>T	c.(4198-4200)CCG>TCG	p.P1400S	EP400_uc001ujl.2_Missense_Mutation_p.P1399S|EP400_uc001ujm.2_Missense_Mutation_p.P1400S	NM_015409	NP_056224	Q96L91	EP400_HUMAN	E1A binding protein p400	1436					histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nuclear speck	ATP binding|DNA binding|helicase activity	p.R1400W(1)		central_nervous_system(4)|ovary(3)|breast(3)|skin(2)	12	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.198)		OV - Ovarian serous cystadenocarcinoma(86;3.01e-08)|Epithelial(86;3.43e-07)|all cancers(50;2.01e-06)		GAAAAAGATACCGCGGAAACT	0.502		NaN											0	0	0	0.134883	0	31	47									
N6AMT2	221143	broad.mit.edu	37	13	21331724	21331724	+	Missense_Mutation	SNP	T	T	A			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr13:21331724T>A	uc001uno.1	-	2	95	c.14A>T	c.(13-15)GAA>GTA	p.E5V	N6AMT2_uc009zzr.1_Missense_Mutation_p.E5V|N6AMT2_uc001unp.2_RNA	NM_174928	NP_777588	Q8WVE0	N6MT2_HUMAN	N-6 adenine-specific DNA methyltransferase 2	5							methyltransferase activity|nucleic acid binding				0		all_cancers(29;5.91e-19)|all_epithelial(30;1.42e-15)|all_lung(29;5.9e-14)|Lung SC(185;0.0367)		all cancers(112;0.000234)|Epithelial(112;0.000471)|OV - Ovarian serous cystadenocarcinoma(117;0.0111)|Lung(94;0.0161)|LUSC - Lung squamous cell carcinoma(192;0.0431)		CTCATCATCTTCCAAATCACT	0.403		NaN											0	0	0	0.080935	0	11	79									
RNF17	56163	broad.mit.edu	37	13	25416223	25416223	+	Missense_Mutation	SNP	C	C	G			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr13:25416223C>G	uc001upr.2	+	19	2568	c.2527C>G	c.(2527-2529)CTT>GTT	p.L843V	RNF17_uc010tdd.1_Missense_Mutation_p.L702V|RNF17_uc010aab.2_RNA|RNF17_uc010tde.1_Missense_Mutation_p.L843V|RNF17_uc001ups.2_Missense_Mutation_p.L782V|RNF17_uc010aac.2_Missense_Mutation_p.L41V|RNF17_uc010aad.2_5'Flank	NM_031277	NP_112567	Q9BXT8	RNF17_HUMAN	ring finger protein 17	843					multicellular organismal development	cytoplasm|nucleus	hydrolase activity, acting on ester bonds|nucleic acid binding|zinc ion binding			ovary(1)|skin(1)	2		Lung SC(185;0.0225)|Breast(139;0.077)		all cancers(112;0.0114)|OV - Ovarian serous cystadenocarcinoma(117;0.0311)|Epithelial(112;0.0524)		TTTCGATTCTCTTGGTGCTCC	0.333		NaN											0	0	0	0.038147	0	7	70									
SMAD9	4093	broad.mit.edu	37	13	37439763	37439763	+	Nonsense_Mutation	SNP	G	G	C			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr13:37439763G>C	uc001uvw.2	-	5	1257	c.914C>G	c.(913-915)TCA>TGA	p.S305*	SMAD9_uc001uvx.2_Nonsense_Mutation_p.S268*|SMAD9_uc010tep.1_Nonsense_Mutation_p.S98*	NM_001127217	NP_001120689	O15198	SMAD9_HUMAN	SMAD family member 9 isoform a	305	MH2.				BMP signaling pathway|transforming growth factor beta receptor signaling pathway	cytosol|transcription factor complex	sequence-specific DNA binding transcription factor activity|transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity				0		Breast(139;0.0615)|Lung SC(185;0.0743)|Prostate(109;0.184)		all cancers(112;3.38e-07)|Epithelial(112;1.93e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00804)|BRCA - Breast invasive adenocarcinoma(63;0.0129)|GBM - Glioblastoma multiforme(144;0.026)		CCTGTTATTTGAAGGGTCGGT	0.453		NaN											0	0	0	0.076483	0	23	45									
LHFP	10186	broad.mit.edu	37	13	39918097	39918097	+	Missense_Mutation	SNP	C	C	G	rs142420975		TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr13:39918097C>G	uc001uxf.2	-	4	1090	c.579G>C	c.(577-579)AAG>AAC	p.K193N		NM_005780	NP_005771	Q9Y693	LHFP_HUMAN	lipoma HMGIC fusion partner precursor	193						integral to membrane	DNA binding		HMGA2/LHFP(2)	soft_tissue(2)|lung(1)|breast(1)	4		Lung NSC(96;3.55e-06)|Breast(139;0.00408)|Ovarian(182;0.0107)|Prostate(109;0.0118)|Lung SC(185;0.0719)|Hepatocellular(188;0.114)		OV - Ovarian serous cystadenocarcinoma(117;6.48e-46)|Epithelial(112;8.43e-42)|all cancers(112;1.42e-36)|GBM - Glioblastoma multiforme(144;0.00187)|BRCA - Breast invasive adenocarcinoma(63;0.00886)|KIRC - Kidney renal clear cell carcinoma(186;0.048)|Kidney(163;0.0601)|LUSC - Lung squamous cell carcinoma(192;0.105)		GCTTCTGTTTCTTGCCCGAAA	0.557		NaN	T	HMGA2	lipoma								0	0	0	0.124865	0	45	43									
PCDH8	5100	broad.mit.edu	37	13	53420180	53420180	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr13:53420180C>T	uc001vhi.2	-	1	2595	c.2392G>A	c.(2392-2394)GGA>AGA	p.G798R	PCDH8_uc001vhj.2_Intron	NM_002590	NP_002581	O95206	PCDH8_HUMAN	protocadherin 8 isoform 1 precursor	798	Cytoplasmic (Potential).				cell-cell signaling|homophilic cell adhesion	cell junction|dendrite|integral to plasma membrane|postsynaptic membrane|presynaptic membrane	calcium ion binding			breast(1)	1		Lung NSC(96;0.0019)|Breast(56;0.00235)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;2.19e-08)		GCCGAGGCTccgccgcccgcc	0.637		NaN											0	0	0	0.009096	0	4	12									
DCT	1638	broad.mit.edu	37	13	95114445	95114445	+	Splice_Site	SNP	T	T	A			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr13:95114445T>A	uc001vlv.3	-	5	1291	c.864_splice	c.e5-1	p.S288_splice	DCT_uc010afh.2_Splice_Site_p.S288_splice	NM_001922	NP_001913	P40126	TYRP2_HUMAN	dopachrome tautomerase isoform 1						epidermis development|melanin biosynthetic process from tyrosine	cytosol|integral to membrane|melanosome membrane|microsome	copper ion binding|dopachrome isomerase activity|oxidoreductase activity			ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	5	all_neural(89;0.0684)|Medulloblastoma(90;0.163)	all_cancers(2;3.71e-42)|all_epithelial(2;3.76e-31)|all_lung(2;5.16e-14)|Lung NSC(4;1.33e-13)|Breast(118;0.0013)|Hepatocellular(115;0.00886)|Renal(2;0.00988)		COAD - Colon adenocarcinoma(199;7.07e-05)|GBM - Glioblastoma multiforme(99;0.000472)		TCATCCAAGCTAAGATTTGTA	0.239		NaN											0	0	0	0.047766	0	9	47									
NALCN	259232	broad.mit.edu	37	13	101944717	101944717	+	Missense_Mutation	SNP	C	C	G			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr13:101944717C>G	uc001vox.1	-	8	989	c.800G>C	c.(799-801)GGA>GCA	p.G267A	NALCN_uc001voy.2_5'UTR|NALCN_uc001voz.2_Missense_Mutation_p.G267A|NALCN_uc001vpa.2_Missense_Mutation_p.G267A	NM_052867	NP_443099	Q8IZF0	NALCN_HUMAN	voltage gated channel like 1	267	Extracellular (Potential).					integral to membrane	sodium channel activity|voltage-gated ion channel activity			ovary(8)|breast(4)|skin(2)|pancreas(1)|central_nervous_system(1)	16	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					TATACTAGTTCCTGTCATGAC	0.433		NaN											0	0	0	0.076483	0	23	28									
MCF2L	23263	broad.mit.edu	37	13	113729380	113729380	+	Silent	SNP	G	G	A			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr13:113729380G>A	uc001vsu.2	+	11	1378	c.1356G>A	c.(1354-1356)GCG>GCA	p.A452A	MCF2L_uc001vsq.2_Silent_p.A452A|MCF2L_uc010tjr.1_Silent_p.A395A|MCF2L_uc001vsr.2_Silent_p.A399A|MCF2L_uc001vss.3_Silent_p.A393A|MCF2L_uc010tjs.1_Silent_p.A393A|MCF2L_uc001vst.1_Silent_p.A357A	NM_001112732	NP_001106203	O15068	MCF2L_HUMAN	MCF.2 cell line derived transforming	425	Spectrin.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|plasma membrane	Rho guanyl-nucleotide exchange factor activity			ovary(1)|kidney(1)	2	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)	all_cancers(25;0.118)|all_lung(25;0.0368)|all_epithelial(44;0.0396)|Lung NSC(25;0.129)|Breast(118;0.188)				AGCACTACGCGGTAGACTCCA	0.657		NaN											0	0	0	0.125774	0	28	62									
RNASE4	6038	broad.mit.edu	37	14	21167916	21167916	+	Missense_Mutation	SNP	G	G	C			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr14:21167916G>C	uc001vxy.3	+	2	949	c.386G>C	c.(385-387)AGA>ACA	p.R129T	RNASE4_uc001vxx.3_RNA|RNASE4_uc001vya.2_Missense_Mutation_p.R129T	NM_002937	NP_002928	P34096	RNAS4_HUMAN	ribonuclease, RNase A family, 4 precursor	129					mRNA cleavage	extracellular region	nucleic acid binding|pancreatic ribonuclease activity			central_nervous_system(1)	1	all_cancers(95;0.00304)		Epithelial(56;5.13e-07)|all cancers(55;4.73e-06)	GBM - Glioblastoma multiforme(265;0.0133)		GCGAGCACTAGACGTGTTGTC	0.527		NaN											0	0	0	0.139131	0	88	104									
BAZ1A	11177	broad.mit.edu	37	14	35227931	35227931	+	Missense_Mutation	SNP	C	C	G			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr14:35227931C>G	uc001wsk.2	-	25	4933	c.4365G>C	c.(4363-4365)TTG>TTC	p.L1455F	BAZ1A_uc001wsl.2_Missense_Mutation_p.L1423F	NM_013448	NP_038476	Q9NRL2	BAZ1A_HUMAN	bromodomain adjacent to zinc finger domain, 1A	1455	Bromo.				chromatin remodeling|regulation of transcription, DNA-dependent|transcription, DNA-dependent	ACF complex	zinc ion binding			lung(2)|central_nervous_system(2)|ovary(1)|breast(1)|skin(1)	7	Breast(36;0.0388)|Hepatocellular(127;0.158)		LUAD - Lung adenocarcinoma(48;7.23e-05)|Lung(238;0.00019)|Epithelial(34;0.0793)|all cancers(34;0.175)	GBM - Glioblastoma multiforme(112;0.0659)		AAACAAGTTTCAAAAAAGGCC	0.373		NaN											0	0	0	0.069288	0	24	62									
ZFYVE26	23503	broad.mit.edu	37	14	68264823	68264823	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr14:68264823C>T	uc001xka.2	-	11	2295	c.2156G>A	c.(2155-2157)AGA>AAA	p.R719K	ZFYVE26_uc010tsz.1_RNA|ZFYVE26_uc001xkc.3_Missense_Mutation_p.R719K|ZFYVE26_uc010tta.1_Missense_Mutation_p.R719K	NM_015346	NP_056161	Q68DK2	ZFY26_HUMAN	zinc finger, FYVE domain containing 26	719					cell cycle|cell death|cytokinesis|double-strand break repair via homologous recombination	centrosome|midbody	metal ion binding|phosphatidylinositol-3-phosphate binding|protein binding			ovary(9)|breast(2)	11				all cancers(60;0.000763)|OV - Ovarian serous cystadenocarcinoma(108;0.0011)|BRCA - Breast invasive adenocarcinoma(234;0.0115)		CAGTCCATCTCTGCTTCCTGA	0.557		NaN											0	0	0	0.139131	0	62	71									
VASH1	22846	broad.mit.edu	37	14	77242405	77242405	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr14:77242405G>A	uc001xst.2	+	5	1631	c.701G>A	c.(700-702)CGC>CAC	p.R234H		NM_014909	NP_055724	Q7L8A9	VASH1_HUMAN	vasohibin 1	234					cell cycle arrest|negative regulation of angiogenesis|negative regulation of blood vessel endothelial cell migration|negative regulation of endothelial cell proliferation	endoplasmic reticulum|extracellular space					0			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0283)		CCCGCCTTCCGCACGCTCAGC	0.672		NaN											0	0	0	0.038147	0	7	19									
FLRT2	23768	broad.mit.edu	37	14	86089433	86089433	+	Silent	SNP	A	A	G			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr14:86089433A>G	uc001xvr.2	+	2	2342	c.1575A>G	c.(1573-1575)ACA>ACG	p.T525T	FLRT2_uc010atd.2_Silent_p.T525T	NM_013231	NP_037363	O43155	FLRT2_HUMAN	fibronectin leucine rich transmembrane protein 2	525	Extracellular (Potential).				cell adhesion	integral to plasma membrane|proteinaceous extracellular matrix	protein binding, bridging|receptor signaling protein activity			ovary(3)|haematopoietic_and_lymphoid_tissue(1)	4				BRCA - Breast invasive adenocarcinoma(234;0.0319)		GCAGCAACACAGCGTCCAGCC	0.577		NaN											0	0	0	0.055883	0	21	143									
MOAP1	64112	broad.mit.edu	37	14	93650482	93650482	+	Nonsense_Mutation	SNP	C	C	A			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr14:93650482C>A	uc001ybj.2	-	3	476	c.106G>T	c.(106-108)GAG>TAG	p.E36*	C14orf109_uc001ybk.3_5'Flank|C14orf109_uc010auo.2_5'Flank	NM_022151	NP_071434	Q96BY2	MOAP1_HUMAN	modulator of apoptosis 1	36					activation of caspase activity|apoptotic nuclear change	cytoplasm	protein homodimerization activity			skin(2)|ovary(1)	3		all_cancers(154;0.00528)|Acute lymphoblastic leukemia(33;0.0497)|all_epithelial(191;0.125)|all_neural(303;0.13)		Epithelial(152;0.178)|all cancers(159;0.2)|COAD - Colon adenocarcinoma(157;0.204)		agagcctcctcgatttctgcc	0		NaN											1	0	7.97055e-49	0.139131	8.90698e-49	122	147									
BCL11B	64919	broad.mit.edu	37	14	99641436	99641436	+	Silent	SNP	C	C	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr14:99641436C>T	uc001yga.2	-	4	2004	c.1737G>A	c.(1735-1737)GCG>GCA	p.A579A	BCL11B_uc001ygb.2_Silent_p.A508A	NM_138576	NP_612808	Q9C0K0	BC11B_HUMAN	B-cell CLL/lymphoma 11B isoform 1	579	Gly-rich.					nucleus	zinc ion binding			central_nervous_system(8)|large_intestine(1)|lung(1)	10		Melanoma(154;0.0866)|all_epithelial(191;0.241)		COAD - Colon adenocarcinoma(157;0.103)		cgccgccccccgcgcccggga	0.557		NaN	T	TLX3	T-ALL								0	0	0	0.047766	0	8	19									
HSP90AA1	3320	broad.mit.edu	37	14	102549376	102549376	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr14:102549376C>T	uc001yku.3	-	9	1940	c.1750G>A	c.(1750-1752)GAA>AAA	p.E584K	HSP90AA1_uc001ykv.3_Missense_Mutation_p.E706K|HSP90AA1_uc001ykw.1_Missense_Mutation_p.E405K|HSP90AA1_uc001ykx.1_Missense_Mutation_p.E573K	NM_005348	NP_005339	P07900	HS90A_HUMAN	heat shock 90kDa protein 1, alpha isoform 2	584					axon guidance|cellular chaperone-mediated protein complex assembly|G2/M transition of mitotic cell cycle|nitric oxide metabolic process|positive regulation of nitric oxide biosynthetic process|protein import into mitochondrial outer membrane|protein refolding|regulation of nitric-oxide synthase activity|response to unfolded protein|signal transduction	cytosol|melanosome|plasma membrane	ATP binding|ATPase activity|nitric-oxide synthase regulator activity|protein homodimerization activity|TPR domain binding|unfolded protein binding			ovary(2)|central_nervous_system(2)|prostate(1)|lung(1)|breast(1)	7					Rifabutin(DB00615)	CATACCTTTTCAACTTTTTTC	0.194		NaN											0	0	0	0.050027	0	35	34									
HERC2	8924	broad.mit.edu	37	15	28456214	28456214	+	Missense_Mutation	SNP	G	G	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr15:28456214G>T	uc001zbj.2	-	44	7109	c.7003C>A	c.(7003-7005)CAC>AAC	p.H2335N		NM_004667	NP_004658	O95714	HERC2_HUMAN	hect domain and RLD 2	2335					DNA repair|intracellular protein transport|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	guanyl-nucleotide exchange factor activity|heme binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(4)|lung(4)|skin(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	13		all_lung(180;1.3e-11)|Breast(32;0.000194)|Colorectal(260;0.227)		all cancers(64;3.93e-09)|Epithelial(43;9.99e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0271)|GBM - Glioblastoma multiforme(186;0.0497)|Lung(196;0.199)		TTATCCTGGTGGGAGAGCAGC	0.502		NaN											1	0	1.56452e-12	0.043863	1.67073e-12	19	116									
SEMA6D	80031	broad.mit.edu	37	15	48057100	48057100	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr15:48057100C>T	uc010bek.2	+	13	1634	c.1274C>T	c.(1273-1275)TCA>TTA	p.S425L	SEMA6D_uc001zvw.2_Missense_Mutation_p.S425L|SEMA6D_uc001zvx.1_Missense_Mutation_p.S425L|SEMA6D_uc001zvy.2_Missense_Mutation_p.S425L|SEMA6D_uc001zvz.2_Missense_Mutation_p.S425L|SEMA6D_uc001zwa.2_Missense_Mutation_p.S425L|SEMA6D_uc001zwb.2_Missense_Mutation_p.S425L|SEMA6D_uc001zwc.2_Missense_Mutation_p.S425L	NM_153618	NP_705871	Q8NFY4	SEM6D_HUMAN	semaphorin 6D isoform 4 precursor	425	Sema.|Extracellular (Potential).				axon guidance	cytoplasm|integral to membrane|plasma membrane	receptor activity			skin(3)|breast(1)	4		all_lung(180;0.000635)|Myeloproliferative disorder(241;0.116)|Melanoma(134;0.18)		all cancers(107;1.2e-11)|GBM - Glioblastoma multiforme(94;1.2e-06)		ACGGCCATCTCAGTGGACCAT	0.512		NaN											0	0	0	0.055883	0	22	60									
MYO9A	4649	broad.mit.edu	37	15	72122642	72122642	+	Missense_Mutation	SNP	C	C	T	rs142345927	byFrequency	TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr15:72122642C>T	uc002atl.3	-	40	7321	c.6848G>A	c.(6847-6849)CGT>CAT	p.R2283H	MYO9A_uc002atj.2_Missense_Mutation_p.R214H|MYO9A_uc002atk.2_Missense_Mutation_p.R1078H	NM_006901	NP_008832	B2RTY4	MYO9A_HUMAN	myosin IXA	2283	Tail.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction|visual perception	cytosol|integral to membrane|unconventional myosin complex	actin binding|ATP binding|GTPase activator activity|metal ion binding|motor activity	p.R2283H(1)		ovary(1)|pancreas(1)|skin(1)	3						TCGACGAATACGCCCCTTTCC	0.443		NaN											0	0	0	0.009096	0	4	89									
ULK3	25989	broad.mit.edu	37	15	75134485	75134485	+	Silent	SNP	G	G	A			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr15:75134485G>A	uc010bkf.1	-	3	401	c.295C>T	c.(295-297)CTG>TTG	p.L99L	ULK3_uc010ulp.1_Silent_p.L9L|ULK3_uc010ulq.1_Silent_p.L110L|ULK3_uc010ulr.1_Intron|ULK3_uc002ayv.2_Silent_p.L99L|ULK3_uc010uls.1_Intron|ULK3_uc010ult.1_Silent_p.L9L|ULK3_uc010ulu.1_Silent_p.L9L	NM_001099436	NP_001092906	Q6PHR2	ULK3_HUMAN	unc-51-like kinase 3	99	Protein kinase.					cytoplasm	ATP binding|protein serine/threonine kinase activity			breast(2)	2						AAGCGAGACAGGTCGCCCCCT	0.547		NaN											0	0	0	0.014758	0	5	104									
AEN	64782	broad.mit.edu	37	15	89173447	89173447	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr15:89173447G>A	uc002bmt.2	+	4	1051	c.900G>A	c.(898-900)ATG>ATA	p.M300I	AEN_uc010bnm.1_Missense_Mutation_p.M300I	NM_022767	NP_073604	Q8WTP8	AEN_HUMAN	interferon stimulated exonuclease gene	300					apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|response to ionizing radiation	nucleolus|nucleoplasm	exonuclease activity|nucleic acid binding				0						AACAGTACATGGAGGACCAGT	0.647		NaN											0	0	0	0.014758	0	5	8									
GRIN2A	2903	broad.mit.edu	37	16	9857673	9857673	+	Missense_Mutation	SNP	C	C	A			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr16:9857673C>A	uc002czo.3	-	13	4276	c.3728G>T	c.(3727-3729)GGG>GTG	p.G1243V	GRIN2A_uc010uym.1_Missense_Mutation_p.G1243V|GRIN2A_uc010uyn.1_Missense_Mutation_p.G1086V|GRIN2A_uc002czr.3_Missense_Mutation_p.G1243V	NM_001134407	NP_001127879	Q12879	NMDE1_HUMAN	N-methyl-D-aspartate receptor subunit 2A isoform	1243	Cytoplasmic (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			skin(32)|NS(5)|ovary(4)|large_intestine(1)|lung(1)|breast(1)|kidney(1)	45					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	ATAGAGGTTCCCCATCCGCAG	0.572		NaN											1	0	1.50372e-20	0.139131	1.63136e-20	68	52									
NDE1	54820	broad.mit.edu	37	16	15758666	15758666	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr16:15758666G>A	uc002ddt.1	+	1	74	c.31G>A	c.(31-33)GAG>AAG	p.E11K	NDE1_uc010uzy.1_Missense_Mutation_p.E11K|NDE1_uc002dds.2_Missense_Mutation_p.E11K	NM_017668	NP_060138	Q9NXR1	NDE1_HUMAN	nuclear distribution gene E homolog 1	11	Self-association (By similarity).				cell differentiation|cell division|centrosome duplication|establishment of chromosome localization|establishment of mitotic spindle orientation|G2/M transition of mitotic cell cycle|mitotic prometaphase|nervous system development	cleavage furrow|condensed chromosome kinetochore|cytosol|microtubule|spindle pole centrosome	microtubule binding			ovary(1)	1						TTTCAGCTCCGAGGAGGAAGA	0.408		NaN											0	0	0	0.139131	0	46	98									
XYLT1	64131	broad.mit.edu	37	16	17211827	17211827	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr16:17211827C>T	uc002dfa.2	-	11	2318	c.2233G>A	c.(2233-2235)GAC>AAC	p.D745N		NM_022166	NP_071449	Q86Y38	XYLT1_HUMAN	xylosyltransferase I	745	Lumenal (Potential).			D->G: Abolishes enzyme activity but does not affect UDP-binding.|D->E: No effect.	glycosaminoglycan biosynthetic process	endoplasmic reticulum membrane|extracellular region|Golgi membrane|integral to membrane	acetylglucosaminyltransferase activity|protein xylosyltransferase activity			ovary(4)	4						GCATCCCAGTCAGTGCCGACC	0.547		NaN											0	0	0	0.105934	0	11	56									
KIAA0556	23247	broad.mit.edu	37	16	27761548	27761548	+	Silent	SNP	G	G	A			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr16:27761548G>A	uc002dow.2	+	16	3291	c.3267G>A	c.(3265-3267)GTG>GTA	p.V1089V		NM_015202	NP_056017	O60303	K0556_HUMAN	hypothetical protein LOC23247	1089										ovary(4)|large_intestine(2)|upper_aerodigestive_tract(1)|skin(1)	8						TCCGAGGCGTGAAGGACATCA	0.502		NaN											0	0	0	0.086207	0	41	72									
ATXN2L	11273	broad.mit.edu	37	16	28840778	28840778	+	Silent	SNP	G	G	A			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr16:28840778G>A	uc002drc.2	+	7	966	c.798G>A	c.(796-798)GTG>GTA	p.V266V	uc010vct.1_Intron|ATXN2L_uc010byl.1_Silent_p.V266V|ATXN2L_uc002drb.2_Silent_p.V266V|ATXN2L_uc002dqy.2_Silent_p.V266V|ATXN2L_uc002dra.2_Silent_p.V266V|ATXN2L_uc002dqz.2_Silent_p.V266V|ATXN2L_uc010vdb.1_Silent_p.V266V|ATXN2L_uc002dre.2_Silent_p.V266V|ATXN2L_uc002drf.2_Intron	NM_007245	NP_009176	Q8WWM7	ATX2L_HUMAN	ataxin 2 related protein isoform A	266						membrane				upper_aerodigestive_tract(1)|ovary(1)	2						ACTACGGTGTGAAGACTACCT	0.458		NaN											0	0	0	0.02938	0	6	58									
SEZ6L2	26470	broad.mit.edu	37	16	29900017	29900017	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr16:29900017G>A	uc002duq.3	-	6	1123	c.883C>T	c.(883-885)CGG>TGG	p.R295W	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|SEZ6L2_uc002dup.3_Missense_Mutation_p.R225W|SEZ6L2_uc002dur.3_Missense_Mutation_p.R225W|SEZ6L2_uc002dus.3_Missense_Mutation_p.R181W|SEZ6L2_uc010vec.1_Missense_Mutation_p.R295W|SEZ6L2_uc010ved.1_Missense_Mutation_p.R251W	NM_201575	NP_963869	Q6UXD5	SE6L2_HUMAN	seizure related 6 homolog (mouse)-like 2 isoform	295	Sushi 1.|Extracellular (Potential).					endoplasmic reticulum membrane|integral to membrane|plasma membrane				ovary(1)|skin(1)	2						TGGGCCGGCCGGGGAGGGAAG	0.642		NaN											0	0	0	0.099896	0	23	30									
STX4	6810	broad.mit.edu	37	16	31051055	31051055	+	Missense_Mutation	SNP	G	G	C			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr16:31051055G>C	uc002eal.2	+	10	1049	c.825G>C	c.(823-825)TTG>TTC	p.L275F	STX4_uc002eak.2_Missense_Mutation_p.L273F|STX4_uc002eam.2_Missense_Mutation_p.L197F|uc002ean.1_5'Flank	NM_004604	NP_004595	Q12846	STX4_HUMAN	syntaxin 4	275	Cytoplasmic (Potential).|Interaction with CENPF (By similarity).				intracellular protein transport|platelet activation|post-Golgi vesicle-mediated transport	basolateral plasma membrane|cell surface|cytosol|integral to membrane|plasma membrane enriched fraction|specific granule|vacuole	SNAP receptor activity				0						AGAAAGTCTTGATTGCCATCT	0.572		NaN											0	0	0	0.139131	0	80	181									
KARS	3735	broad.mit.edu	37	16	75670391	75670391	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr16:75670391C>T	uc002feq.2	-	4	491	c.443G>A	c.(442-444)CGA>CAA	p.R148Q	KARS_uc002fer.2_Missense_Mutation_p.R176Q|KARS_uc002fes.2_5'UTR|KARS_uc010cgz.2_5'UTR	NM_005548	NP_005539	Q15046	SYK_HUMAN	lysyl-tRNA synthetase isoform 2	148					interspecies interaction between organisms|lysyl-tRNA aminoacylation|tRNA processing	cytosol|extracellular region|mitochondrial matrix|nucleus|plasma membrane|soluble fraction	ATP binding|lysine-tRNA ligase activity|metal ion binding|tRNA binding			ovary(2)	2					L-Lysine(DB00123)	CCCCTCTCCTCGAAGATCATA	0.453		NaN											0	0	0	0.09836	0	38	223									
ADAMTS18	170692	broad.mit.edu	37	16	77356322	77356322	+	Missense_Mutation	SNP	C	C	G			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr16:77356322C>G	uc002ffc.3	-	14	2493	c.2074G>C	c.(2074-2076)GAA>CAA	p.E692Q	ADAMTS18_uc010chc.1_Missense_Mutation_p.E280Q|ADAMTS18_uc002ffe.1_Missense_Mutation_p.E388Q	NM_199355	NP_955387	Q8TE60	ATS18_HUMAN	ADAM metallopeptidase with thrombospondin type 1	692	Cys-rich.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			large_intestine(4)|lung(4)|kidney(4)|skin(3)|breast(1)|ovary(1)|pancreas(1)	18						AAAAAAAATTCAAAGTTCTCA	0.393		NaN											0	0	0	0.038395	0	17	102									
CENPN	55839	broad.mit.edu	37	16	81045675	81045675	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr16:81045675G>A	uc002ffx.2	+	2	921	c.131G>A	c.(130-132)AGA>AAA	p.R44K	CENPN_uc002ffw.3_Missense_Mutation_p.R44K|CENPN_uc010vnl.1_Missense_Mutation_p.R44K|CENPN_uc010vnm.1_Missense_Mutation_p.R44K|CENPN_uc002ffy.3_Missense_Mutation_p.R44K	NM_001100624	NP_001094094	Q96H22	CENPN_HUMAN	centromere protein N isoform 2	44					CenH3-containing nucleosome assembly at centromere|mitotic prometaphase	condensed chromosome kinetochore|cytosol|nucleoplasm					0						TTCCGACAGAGAAAGGAATCT	0.418		NaN											0	0	0	0.069234	0	11	79									
PKD1L2	114780	broad.mit.edu	37	16	81194496	81194496	+	Silent	SNP	C	C	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr16:81194496C>T	uc002fgh.1	-	22	3492	c.3492G>A	c.(3490-3492)CGG>CGA	p.R1164R	PKD1L2_uc002fgg.1_RNA	NM_052892	NP_443124	Q7Z442	PK1L2_HUMAN	polycystin 1-like 2 isoform a	1164	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity|sugar binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3						TTTGTGAATGCCGGGGCAGCA	0.562		NaN											0	0	0	0.009096	0	3	51									
ZC3H18	124245	broad.mit.edu	37	16	88644047	88644047	+	Missense_Mutation	SNP	G	G	C			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr16:88644047G>C	uc002fky.2	+	2	716	c.516G>C	c.(514-516)CAG>CAC	p.Q172H	ZC3H18_uc010voy.1_Intron|ZC3H18_uc010voz.1_Missense_Mutation_p.Q172H|ZC3H18_uc010vpa.1_Missense_Mutation_p.Q172H	NM_144604	NP_653205	Q86VM9	ZCH18_HUMAN	zinc finger CCCH-type containing 18	172						nucleus	nucleic acid binding|zinc ion binding			skin(1)	1				BRCA - Breast invasive adenocarcinoma(80;0.0542)		CTGGTGTTCAGAGTGTGGGAG	0.557		NaN											0	0	0	0.058154	0	7	60									
CDT1	81620	broad.mit.edu	37	16	88870299	88870299	+	Missense_Mutation	SNP	C	C	G			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr16:88870299C>G	uc002flu.2	+	1	114	c.60C>G	c.(58-60)ATC>ATG	p.I20M		NM_030928	NP_112190	Q9H211	CDT1_HUMAN	chromatin licensing and DNA replication factor	20	PIP-box K+4 motif.				DNA replication|DNA replication checkpoint|M/G1 transition of mitotic cell cycle|regulation of DNA-dependent DNA replication initiation|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle	cytosol|nucleoplasm	DNA binding|protein binding			central_nervous_system(1)	1				BRCA - Breast invasive adenocarcinoma(80;0.0476)		ccccccgcATCGCGCCGCCCA	0.572		NaN											0	0	0	0.115264	0	2	7									
TCF25	22980	broad.mit.edu	37	16	89952289	89952289	+	Missense_Mutation	SNP	G	G	C			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr16:89952289G>C	uc002fpb.2	+	4	545	c.463G>C	c.(463-465)GAG>CAG	p.E155Q	TCF25_uc002fpc.2_5'UTR	NM_014972	NP_055787	Q9BQ70	TCF25_HUMAN	NULP1	155					heart development|negative regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity				0		all_cancers(9;4.71e-08)|Lung NSC(15;0.000192)|all_lung(18;0.000319)|all_neural(9;0.0122)|all_hematologic(23;0.027)		BRCA - Breast invasive adenocarcinoma(80;0.0288)		TCGCATCCTAGAGAGGATTGA	0.458		NaN											0	0	0	0.139131	0	48	60									
VPS53	55275	broad.mit.edu	37	17	556596	556596	+	Silent	SNP	C	C	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr17:556596C>T	uc002frn.2	-	7	690	c.543G>A	c.(541-543)GTG>GTA	p.V181V	VPS53_uc002frk.2_Intron|VPS53_uc010cjo.1_Silent_p.V181V|VPS53_uc002frl.2_RNA|VPS53_uc002frm.2_Silent_p.V152V|VPS53_uc002fro.2_5'UTR|VPS53_uc010cjp.1_Intron	NM_018289	NP_060759	Q5VIR6	VPS53_HUMAN	vacuolar protein sorting 53 isoform 2	181					protein transport	endosome membrane|Golgi apparatus					0				UCEC - Uterine corpus endometrioid carcinoma (25;0.0265)		GGACATTCATCACACCCTGAA	0.448		NaN											0	0	0	0.076483	0	23	265									
P2RX5	5026	broad.mit.edu	37	17	3593444	3593444	+	Silent	SNP	C	C	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr17:3593444C>T	uc002fwi.2	-	6	818	c.534G>A	c.(532-534)GAG>GAA	p.E178E	P2RX5_uc002fwd.2_RNA|P2RX5_uc002fwh.1_Silent_p.E178E|P2RX5_uc010vrx.1_Silent_p.E118E|P2RX5_uc002fwj.2_Silent_p.E154E|P2RX5_uc002fwk.2_Silent_p.E178E|P2RX5_uc002fwl.2_Silent_p.E154E	NM_002561	NP_002552	Q93086	P2RX5_HUMAN	purinergic receptor P2X5 isoform A	178	Extracellular (Potential).				nervous system development|positive regulation of calcium ion transport into cytosol|positive regulation of calcium-mediated signaling	integral to plasma membrane	ATP binding|extracellular ATP-gated cation channel activity|purinergic nucleotide receptor activity				0						GGAATGGCTCCCTGAAAACCA	0.577		NaN											0	0	0	0.139131	0	50	190									
ZNF232	7775	broad.mit.edu	37	17	5009425	5009425	+	Silent	SNP	G	G	A			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr17:5009425G>A	uc002gas.2	-	5	1702	c.948C>T	c.(946-948)AGC>AGT	p.S316S	ZNF232_uc002gar.1_Silent_p.S334S|ZNF232_uc002gat.2_Silent_p.S343S	NM_014519	NP_055334	Q9UNY5	ZN232_HUMAN	zinc finger protein 232	316	C2H2-type 2.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			large_intestine(1)|ovary(1)	2						CGAGGTTTGAGCTCTGTTTGA	0.433		NaN											0	0	0	0.080935	0	11	206									
TP53	7157	broad.mit.edu	37	17	7578457	7578457	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr17:7578457C>T	uc002gim.2	-	5	667	c.473G>A	c.(472-474)CGC>CAC	p.R158H	TP53_uc002gig.1_Missense_Mutation_p.R158H|TP53_uc002gih.2_Missense_Mutation_p.R158H|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.R26H|TP53_uc010cng.1_Missense_Mutation_p.R26H|TP53_uc002gii.1_Missense_Mutation_p.R26H|TP53_uc010cnh.1_Missense_Mutation_p.R158H|TP53_uc010cni.1_Missense_Mutation_p.R158H|TP53_uc002gij.2_Missense_Mutation_p.R158H|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.R65H|TP53_uc002gio.2_Missense_Mutation_p.R26H|TP53_uc010vug.1_Missense_Mutation_p.R119H	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	158	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		R -> F (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|R -> H (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> C (in sporadic cancers; somatic mutation).|R -> P (in sporadic cancers; somatic mutation).|R -> S (in sporadic cancers; somatic mutation).|R -> Q (in a sporadic cancer; somatic mutation).|R -> G (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> L (in sporadic cancers; somatic mutation).|R -> Y (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R158H(58)|p.R158L(55)|p.R158C(17)|p.R158G(10)|p.R158P(9)|p.0?(7)|p.R158R(6)|p.R158fs*12(5)|p.R158_A159insX(4)|p.R158_A159delRA(2)|p.R156_I162delRVRAMAI(2)|p.V157fs*9(2)|p.P153fs*22(2)|p.R158fs*11(2)|p.V157fs*22(2)|p.V157_C176del20(1)|p.R156_A161delRVRAMA(1)|p.R158F(1)|p.P151_V173del23(1)|p.R158fs*24(1)|p.R65L(1)|p.R156_R158delRVR(1)|p.R156fs*18(1)|p.R156_A161del(1)|p.R158_A159insXX(1)|p.V157_M160delVRAM(1)|p.V157_R158delVR(1)|p.S149fs*72(1)|p.A159fs*21(1)|p.T155_A161delTRVRAMA(1)|p.G154fs*22(1)|p.R156fs*20(1)|p.V157_I162delVRAMAI(1)|p.R26L(1)|p.V157fs*21(1)|p.R158fs*8(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GGCCATGGCGCGGACGCGGGT	0.627		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			0	0	0	0.0333	0	17	25									
C17orf68	80169	broad.mit.edu	37	17	8141719	8141719	+	Silent	SNP	C	C	G			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr17:8141719C>G	uc002gkq.3	-	3	485	c.426G>C	c.(424-426)CTG>CTC	p.L142L	C17orf68_uc010cnv.2_RNA	NM_025099	NP_079375	Q2NKJ3	CTC1_HUMAN	alpha accessory factor 132	142					positive regulation of DNA replication|telomere maintenance	Stn1-Ten1 complex	protein binding|single-stranded DNA binding				0						CCTCACAGCTCAGGACGCCAG	0.488		NaN											0	0	0	0.074837	0	36	224									
MYH13	8735	broad.mit.edu	37	17	10235464	10235464	+	Silent	SNP	G	G	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr17:10235464G>T	uc002gmk.1	-	20	2340	c.2250C>A	c.(2248-2250)CTC>CTA	p.L750L		NM_003802	NP_003793	Q9UKX3	MYH13_HUMAN	myosin, heavy polypeptide 13, skeletal muscle	750	Myosin head-like.				muscle contraction	muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(4)|skin(2)	6						CGATGGAGTTGAGGAGCTTCT	0.552		NaN											1	0	1.05317e-09	0.11911	1.11017e-09	14	130									
MYH1	4619	broad.mit.edu	37	17	10415489	10415489	+	Missense_Mutation	SNP	G	G	C			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr17:10415489G>C	uc002gmo.2	-	13	1262	c.1168C>G	c.(1168-1170)CTC>GTC	p.L390V	uc002gml.1_Intron	NM_005963	NP_005954	P12882	MYH1_HUMAN	myosin, heavy chain 1, skeletal muscle, adult	390	Myosin head-like.					muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			ovary(10)|skin(6)|breast(3)|upper_aerodigestive_tract(1)|kidney(1)	21						AGATTTTGGAGATAGGCTGCC	0.453		NaN											0	0	0	0.139131	0	238	219									
MYH3	4621	broad.mit.edu	37	17	10542949	10542949	+	Silent	SNP	G	G	C			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr17:10542949G>C	uc002gmq.1	-	22	2930	c.2853C>G	c.(2851-2853)CTC>CTG	p.L951L		NM_002470	NP_002461	P11055	MYH3_HUMAN	myosin, heavy chain 3, skeletal muscle,	951	Potential.				muscle filament sliding|muscle organ development	cytosol|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(4)|central_nervous_system(2)|pancreas(1)	7						TGTCTTTCTTGAGCTCTGAGC	0.478		NaN											0	0	0	0.139131	0	117	297									
LGALS9	3965	broad.mit.edu	37	17	25967659	25967659	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr17:25967659C>T	uc002gzp.2	+	3	311	c.193C>T	c.(193-195)CGG>TGG	p.R65W	LGALS9_uc002gzq.2_Missense_Mutation_p.R65W|LGALS9_uc002gzr.2_Intron|LGALS9_uc010waa.1_Intron|LGALS9_uc002gzs.2_Missense_Mutation_p.R65W	NM_009587	NP_033665	O00182	LEG9_HUMAN	galectin-9 isoform long	65	Galectin 1.	Beta-galactoside 1.			positive regulation of I-kappaB kinase/NF-kappaB cascade	cytoplasm|extracellular region	galactose binding|signal transducer activity				0	Lung NSC(42;0.0103)		BRCA - Breast invasive adenocarcinoma(3;0.0141)	UCEC - Uterine corpus endometrioid carcinoma (53;0.155)		CTTCAACCCTCGGTTTGAAGA	0.537		NaN											0	0	0	0.139131	0	48	69									
SUPT6H	6830	broad.mit.edu	37	17	27000441	27000441	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr17:27000441G>A	uc002hby.2	+	2	112	c.22G>A	c.(22-24)GAG>AAG	p.E8K	SUPT6H_uc010crt.2_Missense_Mutation_p.E8K	NM_003170	NP_003161	Q7KZ85	SPT6H_HUMAN	suppressor of Ty 6 homolog	8	Asp/Glu-rich.				chromatin remodeling|regulation of transcription elongation, DNA-dependent|regulation of transcription from RNA polymerase II promoter	nucleus	hydrolase activity, acting on ester bonds|RNA binding|sequence-specific DNA binding transcription factor activity			ovary(2)|skin(1)	3	Lung NSC(42;0.00431)					TGTGGAAAGCGAGGCTGAGGA	0.468		NaN											0	0	0	0.09319	0	9	36									
MYO18A	399687	broad.mit.edu	37	17	27447636	27447636	+	Missense_Mutation	SNP	G	G	C			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr17:27447636G>C	uc002hdt.1	-	7	1884	c.1726C>G	c.(1726-1728)CAG>GAG	p.Q576E	MYO18A_uc010wbc.1_Missense_Mutation_p.Q118E|MYO18A_uc002hds.2_Missense_Mutation_p.Q118E|MYO18A_uc010csa.1_Missense_Mutation_p.Q576E|MYO18A_uc002hdu.1_Missense_Mutation_p.Q576E|MYO18A_uc010wbd.1_Missense_Mutation_p.Q245E	NM_078471	NP_510880	Q92614	MY18A_HUMAN	myosin 18A isoform a	576	Myosin head-like.				anti-apoptosis|DNA metabolic process	ER-Golgi intermediate compartment|myosin complex	ATP binding|DNA binding|DNA-dependent ATPase activity|identical protein binding|motor activity				0			Epithelial(11;4.97e-05)|BRCA - Breast invasive adenocarcinoma(11;0.000221)|all cancers(11;0.000234)|Colorectal(6;0.0102)|COAD - Colon adenocarcinoma(6;0.031)			ACTCTCACCTGAATGGAGGCT	0.562		NaN											0	0	0	0.132662	0	16	26									
EFCAB5	374786	broad.mit.edu	37	17	28405274	28405274	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr17:28405274G>A	uc002het.2	+	15	2971	c.2779G>A	c.(2779-2781)GAA>AAA	p.E927K	EFCAB5_uc010cse.2_Missense_Mutation_p.E682K|EFCAB5_uc010csf.2_Intron	NM_198529	NP_940931	A4FU69	EFCB5_HUMAN	EF-hand calcium binding domain 5 isoform a	927							calcium ion binding			ovary(1)|skin(1)	2						CCCTGGTCACGAAGTGAGATT	0.413		NaN											0	0	0	0.083992	0	25	71									
SPACA3	124912	broad.mit.edu	37	17	31324480	31324480	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr17:31324480C>T	uc002hhs.1	+	4	595	c.520C>T	c.(520-522)CTC>TTC	p.L174F	SPACA3_uc010cte.1_RNA	NM_173847	NP_776246	Q8IXA5	SACA3_HUMAN	sperm acrosome associated 3	174	Extracellular (Potential).				cell wall macromolecule catabolic process|defense response to Gram-positive bacterium|monocyte activation|peptidoglycan catabolic process|positive regulation of macrophage activation|positive regulation of phagocytosis|response to virus	acrosomal membrane|extracellular region|integral to membrane|lysosome	bacterial cell surface binding|lysozyme activity|protein binding			ovary(2)	2			BRCA - Breast invasive adenocarcinoma(9;0.193)			GAATCCTAATCTCAAGGATAC	0.413		NaN											0	0	0	0.139131	0	55	101									
SPACA3	124912	broad.mit.edu	37	17	31324482	31324482	+	Silent	SNP	C	C	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr17:31324482C>T	uc002hhs.1	+	4	597	c.522C>T	c.(520-522)CTC>CTT	p.L174L	SPACA3_uc010cte.1_RNA	NM_173847	NP_776246	Q8IXA5	SACA3_HUMAN	sperm acrosome associated 3	174	Extracellular (Potential).				cell wall macromolecule catabolic process|defense response to Gram-positive bacterium|monocyte activation|peptidoglycan catabolic process|positive regulation of macrophage activation|positive regulation of phagocytosis|response to virus	acrosomal membrane|extracellular region|integral to membrane|lysosome	bacterial cell surface binding|lysozyme activity|protein binding			ovary(2)	2			BRCA - Breast invasive adenocarcinoma(9;0.193)			ATCCTAATCTCAAGGATACCG	0.413		NaN											0	0	0	0.139131	0	56	102									
MYO19	80179	broad.mit.edu	37	17	34869487	34869487	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr17:34869487C>T	uc010wcy.1	-	11	1794	c.802G>A	c.(802-804)GAG>AAG	p.E268K	MYO19_uc002hmw.2_Missense_Mutation_p.E268K|MYO19_uc010cuu.2_RNA|MYO19_uc010wcz.1_RNA|MYO19_uc010wda.1_Missense_Mutation_p.E134K|MYO19_uc002hmx.2_Missense_Mutation_p.E268K	NM_001163735	NP_001157207	Q96H55	MYO19_HUMAN	myosin XIX isoform 2	268	Myosin head-like.					mitochondrial outer membrane|myosin complex	actin binding|ATP binding|motor activity			ovary(1)	1		Breast(25;0.00957)|Ovarian(249;0.17)	Kidney(155;0.104)	UCEC - Uterine corpus endometrioid carcinoma (308;0.0185)		AAGCTCCTCTCTGGGTTGGGC	0.602		NaN											0	0	0	0.038147	0	8	34									
ERBB2	2064	broad.mit.edu	37	17	37868208	37868208	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr17:37868208C>T	uc002hso.2	+	8	1167	c.929C>T	c.(928-930)TCC>TTC	p.S310F	ERBB2_uc002hsm.2_Missense_Mutation_p.S280F|ERBB2_uc010cwa.2_Missense_Mutation_p.S295F|ERBB2_uc002hsp.2_Missense_Mutation_p.S113F|ERBB2_uc010cwb.2_Missense_Mutation_p.S310F|ERBB2_uc010wek.1_Missense_Mutation_p.S34F|ERBB2_uc002hsl.2_Missense_Mutation_p.S280F|ERBB2_uc002hsn.1_Missense_Mutation_p.S310F	NM_004448	NP_004439	P04626	ERBB2_HUMAN	erbB-2 isoform a	310	Extracellular (Potential).				cell proliferation|heart development|phosphatidylinositol 3-kinase cascade|phosphatidylinositol-mediated signaling|positive regulation of cell adhesion|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|protein autophosphorylation|regulation of angiogenesis|regulation of microtubule-based process|regulation of transcription, DNA-dependent|transcription, DNA-dependent|wound healing	integral to membrane|nucleus|perinuclear region of cytoplasm|receptor complex	ATP binding|DNA binding|epidermal growth factor receptor activity|ErbB-3 class receptor binding|identical protein binding|protein C-terminus binding|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.S310F(2)|p.S310Y(1)		lung(73)|central_nervous_system(16)|ovary(16)|stomach(14)|breast(9)|upper_aerodigestive_tract(5)|large_intestine(3)|liver(3)|endometrium(2)|skin(1)|pancreas(1)	143	all_cancers(6;1.06e-93)|all_epithelial(6;2.33e-113)|Breast(7;9.37e-100)|Lung NSC(9;9.76e-10)|all_lung(9;5.34e-09)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)	Ovarian(249;0.0547)|Colorectal(1115;0.234)	UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|Epithelial(3;9.42e-64)|all cancers(3;5.61e-57)|BRCA - Breast invasive adenocarcinoma(8;2.5e-45)|STAD - Stomach adenocarcinoma(3;9.03e-13)|Colorectal(5;6.23e-08)|COAD - Colon adenocarcinoma(5;8.58e-06)|Lung(15;0.00193)|LUAD - Lung adenocarcinoma(14;0.0664)|OV - Ovarian serous cystadenocarcinoma(8;0.0917)|LUSC - Lung squamous cell carcinoma(15;0.171)	UCEC - Uterine corpus endometrioid carcinoma (308;0.0767)	Lapatinib(DB01259)|Letrozole(DB01006)|Trastuzumab(DB00072)	GACGTGGGATCCTGCACCCTC	0.582		1	A|Mis|O		breast|ovarian|other tumour types|NSCLC|gastric					TCGA GBM(5;<1E-08)			0	0	0	0.139131	0	101	153									
WNK4	65266	broad.mit.edu	37	17	40939370	40939370	+	Silent	SNP	C	C	A			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr17:40939370C>A	uc002ibj.2	+	7	1572	c.1551C>A	c.(1549-1551)ATC>ATA	p.I517I	WNK4_uc010wgx.1_Silent_p.I181I|WNK4_uc002ibk.1_Silent_p.I289I|WNK4_uc010wgy.1_5'UTR	NM_032387	NP_115763	Q96J92	WNK4_HUMAN	WNK lysine deficient protein kinase 4	517					intracellular protein kinase cascade	tight junction	ATP binding|protein serine/threonine kinase activity			ovary(3)|skin(3)|stomach(1)	7		Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.0749)		TTGCTGCCATCCAGCGAAAGC	0.617		NaN											1	0	6.04164e-23	0.045705	6.57189e-23	32	34									
DDX42	11325	broad.mit.edu	37	17	61869830	61869830	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr17:61869830G>A	uc002jbu.2	+	4	537	c.280G>A	c.(280-282)GAA>AAA	p.E94K	DDX42_uc002jbv.2_Missense_Mutation_p.E94K|DDX42_uc002jbw.1_5'UTR	NM_007372	NP_031398	Q86XP3	DDX42_HUMAN	DEAD box polypeptide 42 protein	94					protein localization|regulation of anti-apoptosis	Cajal body|cytoplasm|nuclear speck	ATP binding|ATP-dependent helicase activity|protein binding|RNA binding			ovary(2)|skin(2)|large_intestine(1)	5						CATTCCTGCTGAAAACTCACC	0.418		NaN											0	0	0	0.139131	0	48	68									
ABCA9	10350	broad.mit.edu	37	17	66979930	66979930	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr17:66979930C>T	uc002jhu.2	-	36	4703	c.4560G>A	c.(4558-4560)ATG>ATA	p.M1520I	ABCA9_uc010dez.2_Missense_Mutation_p.M1482I	NM_080283	NP_525022	Q8IUA7	ABCA9_HUMAN	ATP-binding cassette, sub-family A, member 9	1520	ABC transporter 2.				transport	integral to membrane	ATP binding|ATPase activity			ovary(4)|upper_aerodigestive_tract(1)|central_nervous_system(1)	6	Breast(10;1.47e-12)					TCTTCAGCTTCATCTCCAGCA	0.468		NaN											0	0	0	0.055883	0	21	78									
FBF1	85302	broad.mit.edu	37	17	73924184	73924184	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr17:73924184C>T	uc002jqc.2	-	7	602	c.328G>A	c.(328-330)GAG>AAG	p.E110K	FBF1_uc002jqa.1_RNA|FBF1_uc010wsp.1_Missense_Mutation_p.E100K|FBF1_uc002jqd.1_Missense_Mutation_p.E110K	NM_001080542	NP_001074011	Q8TES7	FBF1_HUMAN	Fas (TNFRSF6) binding factor 1	110											0						TTGGGCAGCTCTCCTTTCCCA	0.537		NaN											0	0	0	0.014758	0	5	38									
TMC8	147138	broad.mit.edu	37	17	76134203	76134203	+	Silent	SNP	C	C	G			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr17:76134203C>G	uc002jup.2	+	12	1849	c.1467C>G	c.(1465-1467)CTC>CTG	p.L489L	TMC8_uc002juq.2_Silent_p.L266L|TMC8_uc010wtr.1_Missense_Mutation_p.L195V|TMC8_uc002jur.1_5'UTR	NM_152468	NP_689681	Q8IU68	TMC8_HUMAN	transmembrane channel-like 8	489	Helical; (Potential).					endoplasmic reticulum membrane|integral to membrane					0			BRCA - Breast invasive adenocarcinoma(99;0.00269)|Lung(188;0.0973)|OV - Ovarian serous cystadenocarcinoma(97;0.192)			GGATGGGCCTCTTCTACTGCC	0.612		NaN							Epidermodysplasia_Verruciformis_Familial_Clustering_of				0	0	0	0.054565	0	34	61									
SYNGR2	9144	broad.mit.edu	37	17	76167089	76167089	+	Silent	SNP	C	C	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr17:76167089C>T	uc002juu.1	+	2	318	c.291C>T	c.(289-291)AAC>AAT	p.N97N	SYNGR2_uc002jut.2_Silent_p.N97N|SYNGR2_uc002juv.1_Silent_p.N97N|SYNGR2_uc010dhi.1_Intron	NM_004710	NP_004701	O43760	SNG2_HUMAN	synaptogyrin 2	97	MARVEL.					integral to plasma membrane					0			BRCA - Breast invasive adenocarcinoma(99;0.00269)|Lung(188;0.0973)|OV - Ovarian serous cystadenocarcinoma(97;0.0994)			AGATCAGCAACGCCACTGACC	0.582		NaN											0	0	0	0.146539	0	17	65									
DNAH17	8632	broad.mit.edu	37	17	76445638	76445638	+	Missense_Mutation	SNP	A	A	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr17:76445638A>T	uc010dhp.1	-	14	2291	c.2069T>A	c.(2068-2070)ATC>AAC	p.I690N	DNAH17_uc002jvq.2_5'UTR|DNAH17_uc002jvs.2_RNA					SubName: Full=DNAH17 variant protein; Flags: Fragment;											ovary(6)|breast(2)|skin(1)	9			BRCA - Breast invasive adenocarcinoma(99;0.00294)|OV - Ovarian serous cystadenocarcinoma(97;0.0656)			GGTCCTCTGGATGGCTTTCTC	0.617		NaN											0	0	0	0.009096	0	4	11									
BAHCC1	57597	broad.mit.edu	37	17	79414364	79414364	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr17:79414364G>A	uc002kaf.2	+	9	3466	c.3466G>A	c.(3466-3468)GAA>AAA	p.E1156K	BAHCC1_uc002kae.2_Missense_Mutation_p.E386K	NM_001080519	NP_001073988	Q9P281	BAHC1_HUMAN	BAH domain and coiled-coil containing 1	1156							DNA binding			ovary(1)	1	all_neural(118;0.0804)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0224)|OV - Ovarian serous cystadenocarcinoma(97;0.116)			GGGGCTACAAGAACTGCAATG	0.697		NaN											0	0	0	0.115264	0	3	10									
ADCYAP1	116	broad.mit.edu	37	18	907685	907685	+	Missense_Mutation	SNP	G	G	C			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr18:907685G>C	uc010dkg.2	+	3	255	c.136G>C	c.(136-138)GAC>CAC	p.D46H	ADCYAP1_uc010dkh.2_Missense_Mutation_p.D46H	NM_001099733	NP_001093203	P18509	PACA_HUMAN	adenylate cyclase activating polypeptide	46					activation of adenylate cyclase activity|cell-cell signaling|female pregnancy|nerve growth factor receptor signaling pathway|regulation of G-protein coupled receptor protein signaling pathway	extracellular region|soluble fraction	neuropeptide hormone activity|peptide hormone receptor binding				0						GTACGGCGAGGACGGAAACCC	0.502		NaN											0	0	0	0.115264	0	2	5									
SMCHD1	23347	broad.mit.edu	37	18	2732308	2732308	+	Missense_Mutation	SNP	C	C	G			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr18:2732308C>G	uc002klm.3	+	25	3283	c.3094C>G	c.(3094-3096)CCC>GCC	p.P1032A	SMCHD1_uc002klk.3_RNA|SMCHD1_uc002kll.3_RNA	NM_015295	NP_056110	A6NHR9	SMHD1_HUMAN	structural maintenance of chromosomes flexible	1032					chromosome organization		ATP binding				0						TAAGTTGCTTCCCAGTAGCCA	0.383		NaN											0	0	0	0.064281	0	35	95									
SMCHD1	23347	broad.mit.edu	37	18	2732428	2732428	+	Missense_Mutation	SNP	C	C	G			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr18:2732428C>G	uc002klm.3	+	25	3403	c.3214C>G	c.(3214-3216)CAA>GAA	p.Q1072E	SMCHD1_uc002klk.3_RNA|SMCHD1_uc002kll.3_RNA	NM_015295	NP_056110	A6NHR9	SMHD1_HUMAN	structural maintenance of chromosomes flexible	1072					chromosome organization		ATP binding				0						TCTTATTTTTCAAATGTATGA	0.303		NaN											0	0	0	0.11911	0	13	36									
VAPA	9218	broad.mit.edu	37	18	9914267	9914267	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr18:9914267C>T	uc002kok.2	+	1	313	c.14C>T	c.(13-15)TCA>TTA	p.S5L	VAPA_uc002koj.2_Missense_Mutation_p.S5L	NM_194434	NP_919415	Q9P0L0	VAPA_HUMAN	vesicle-associated membrane protein-associated	5	Cytoplasmic (Potential).				cell death|cellular membrane fusion|neuron projection development|positive regulation of I-kappaB kinase/NF-kappaB cascade|protein localization in endoplasmic reticulum|sphingolipid metabolic process	endoplasmic reticulum membrane|integral to membrane|plasma membrane|vesicle	protein heterodimerization activity|signal transducer activity|structural molecule activity				0						GCGTCCGCCTCAGGGGCCATG	0.597		NaN											0	0	0	0.009096	0	4	17									
CTAGE1	64693	broad.mit.edu	37	18	19995722	19995722	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr18:19995722C>T	uc002ktv.1	-	1	2157	c.2053G>A	c.(2053-2055)GGA>AGA	p.G685R		NM_172241	NP_758441	Q96RT6	CTGE2_HUMAN	cutaneous T-cell lymphoma-associated antigen 1	685	Pro-rich.					integral to membrane				ovary(1)	1	all_cancers(21;0.000361)|all_epithelial(16;9.61e-06)|Colorectal(14;0.0533)|Lung NSC(20;0.0605)|Ovarian(2;0.116)|all_lung(20;0.135)					AAAGGAGGTCCTCTTCTTATG	0.507		NaN											0	0	0	0.139131	0	73	122									
LAMA3	3909	broad.mit.edu	37	18	21399954	21399954	+	Nonsense_Mutation	SNP	C	C	G			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr18:21399954C>G	uc002kuq.2	+	19	2383	c.2297C>G	c.(2296-2298)TCA>TGA	p.S766*	LAMA3_uc002kur.2_Nonsense_Mutation_p.S766*	NM_198129	NP_937762	Q16787	LAMA3_HUMAN	laminin alpha 3 subunit isoform 1	766					cell adhesion|epidermis development|hemidesmosome assembly|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|skin(2)|central_nervous_system(1)	11	all_cancers(21;7.81e-05)|all_epithelial(16;4.45e-07)|Lung NSC(20;0.00156)|all_lung(20;0.00508)|Colorectal(14;0.0202)|Ovarian(20;0.17)				Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	CAAATGACCTCAGTACAGGTA	0.527		NaN											0	0	0	0.047766	0	9	67									
MOCOS	55034	broad.mit.edu	37	18	33800081	33800081	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr18:33800081C>T	uc002kzq.3	+	9	1884	c.1861C>T	c.(1861-1863)CAC>TAC	p.H621Y		NM_017947	NP_060417	Q96EN8	MOCOS_HUMAN	molybdenum cofactor sulfurase	621					Mo-molybdopterin cofactor biosynthetic process|water-soluble vitamin metabolic process	cytosol	lyase activity|Mo-molybdopterin cofactor sulfurase activity|molybdenum ion binding|pyridoxal phosphate binding			skin(1)	1					Pyridoxal Phosphate(DB00114)	GGTTGTGAATCACAATGGTGT	0.537		NaN											0	0	0	0.076483	0	23	30									
ZNF236	7776	broad.mit.edu	37	18	74607060	74607060	+	Missense_Mutation	SNP	C	C	G			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr18:74607060C>G	uc002lmi.2	+	10	1701	c.1503C>G	c.(1501-1503)ATC>ATG	p.I501M	ZNF236_uc002lmj.2_RNA	NM_007345	NP_031371	Q9UL36	ZN236_HUMAN	zinc finger protein 236	501	C2H2-type 10.				cellular response to glucose stimulus	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)	4		Prostate(75;0.0405)|Esophageal squamous(42;0.129)|Melanoma(33;0.132)		OV - Ovarian serous cystadenocarcinoma(15;4.36e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0686)		TCCGCCACATCCGCATCCACA	0.647		NaN											0	0	0	0.11126	0	42	55									
DAZAP1	26528	broad.mit.edu	37	19	1434835	1434835	+	Missense_Mutation	SNP	G	G	C			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr19:1434835G>C	uc002lsn.2	+	12	1337	c.1148G>C	c.(1147-1149)GGC>GCC	p.G383A	DAZAP1_uc002lsm.2_3'UTR|DAZAP1_uc002lso.2_Missense_Mutation_p.G382A|DAZAP1_uc002lsl.1_Missense_Mutation_p.G382A	NM_018959	NP_061832	Q96EP5	DAZP1_HUMAN	DAZ associated protein 1 isoform b	383	Pro-rich.				cell differentiation|multicellular organismal development|spermatogenesis	cytoplasm|nucleus	nucleotide binding|RNA binding			breast(1)	1		Acute lymphoblastic leukemia(61;3.02e-13)|all_hematologic(61;4.32e-09)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GGGTcggggggcccccccgcc	0.592		NaN											0	0	0	0.11911	0	6	8									
ZFR2	23217	broad.mit.edu	37	19	3819086	3819086	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr19:3819086C>T	uc002lyw.2	-	12	1900	c.1888G>A	c.(1888-1890)GAG>AAG	p.E630K		NM_015174	NP_055989	Q9UPR6	ZFR2_HUMAN	zinc finger RNA binding protein 2 isoform 1	630						intracellular	nucleic acid binding|zinc ion binding			central_nervous_system(1)|pancreas(1)	2				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00514)|STAD - Stomach adenocarcinoma(1328;0.19)		CGGTCCTCCTCGGCCAGTGTG	0.687		NaN											0	0	0	0.02938	0	5	21									
ZBTB7A	51341	broad.mit.edu	37	19	4048230	4048230	+	Silent	SNP	C	C	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr19:4048230C>T	uc002lzh.2	-	3	1350	c.1275G>A	c.(1273-1275)CTG>CTA	p.L425L	ZBTB7A_uc002lzi.2_Silent_p.L425L	NM_015898	NP_056982	O95365	ZBT7A_HUMAN	zinc finger and BTB domain containing 7A	425	C2H2-type 2.				cell differentiation|multicellular organismal development|transcription, DNA-dependent	nucleus	DNA binding|histone acetyltransferase binding|zinc ion binding			pancreas(1)|skin(1)	2		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.014)|STAD - Stomach adenocarcinoma(1328;0.18)		TGTGCACCTTCAGCTTGTCCT	0.697		NaN											0	0	0	0.09319	0	11	21									
ZBTB7A	51341	broad.mit.edu	37	19	4054074	4054074	+	Missense_Mutation	SNP	A	A	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr19:4054074A>T	uc002lzh.2	-	2	1232	c.1157T>A	c.(1156-1158)ATC>AAC	p.I386N	ZBTB7A_uc002lzi.2_Missense_Mutation_p.I386N	NM_015898	NP_056982	O95365	ZBT7A_HUMAN	zinc finger and BTB domain containing 7A	386	C2H2-type 1.				cell differentiation|multicellular organismal development|transcription, DNA-dependent	nucleus	DNA binding|histone acetyltransferase binding|zinc ion binding			pancreas(1)|skin(1)	2		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.014)|STAD - Stomach adenocarcinoma(1328;0.18)		CTTCTCGCAGATGGGGCACTT	0.637		NaN											0	0	0	0.045705	0	29	43									
KIAA1543	57662	broad.mit.edu	37	19	7682676	7682676	+	Silent	SNP	C	C	G			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr19:7682676C>G	uc002mgv.3	+	17	3584	c.3483C>G	c.(3481-3483)CTC>CTG	p.L1161L	KIAA1543_uc002mgu.3_Silent_p.L1188L|KIAA1543_uc002mgw.2_Silent_p.L291L	NM_020902	NP_065953	Q9P1Y5	CAMP3_HUMAN	NEZHA isoform 2	1161	CKK.				epithelial cell-cell adhesion|microtubule anchoring|regulation of microtubule cytoskeleton organization|zonula adherens maintenance	cytoplasm|microtubule|zonula adherens	microtubule minus-end binding			pancreas(1)	1						TCCTGATCCTCTTTCGCGACT	0.637		NaN											0	0	0	0.043863	0	19	40									
MUC16	94025	broad.mit.edu	37	19	9015637	9015637	+	Missense_Mutation	SNP	C	C	G			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr19:9015637C>G	uc002mkp.2	-	29	38390	c.38186G>C	c.(38185-38187)AGA>ACA	p.R12729T	MUC16_uc010xki.1_5'Flank	NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	12731	SEA 5.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						CTGCAGGACTCTCTCTGTGGT	0.532		NaN											0	0	0	0.099896	0	26	150									
MUC16	94025	broad.mit.edu	37	19	9076183	9076183	+	Missense_Mutation	SNP	G	G	C			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr19:9076183G>C	uc002mkp.2	-	3	11467	c.11263C>G	c.(11263-11265)CAG>GAG	p.Q3755E		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	3756	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GTGGCCCCCTGAGGAGCTGAG	0.522		NaN											0	0	0	0.144211	0	30	138									
TYK2	7297	broad.mit.edu	37	19	10488945	10488945	+	Silent	SNP	G	G	A			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr19:10488945G>A	uc002moc.3	-	3	516	c.138C>T	c.(136-138)TTC>TTT	p.F46F	TYK2_uc010dxe.2_Intron|TYK2_uc002mod.2_Silent_p.F46F	NM_003331	NP_003322	P29597	TYK2_HUMAN	tyrosine kinase 2	46	FERM.				intracellular protein kinase cascade|regulation of type I interferon-mediated signaling pathway|type I interferon-mediated signaling pathway	cytoskeleton|cytosol|membrane|nucleus	ATP binding|growth hormone receptor binding|non-membrane spanning protein tyrosine kinase activity			lung(5)|large_intestine(2)|ovary(1)|breast(1)	9			OV - Ovarian serous cystadenocarcinoma(20;1.77e-09)|Epithelial(33;3.92e-06)|all cancers(31;8.95e-06)			ATGACTCACTGAAAGTGACCC	0.622		NaN											0	0	0	0.134883	0	29	45									
ILF3	3609	broad.mit.edu	37	19	10793282	10793282	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr19:10793282G>A	uc002mpn.2	+	13	1767	c.1450G>A	c.(1450-1452)GAG>AAG	p.E484K	ILF3_uc002mpm.2_Missense_Mutation_p.E484K|ILF3_uc002mpl.2_Missense_Mutation_p.E484K|ILF3_uc002mpk.2_Missense_Mutation_p.E484K|ILF3_uc010xli.1_Missense_Mutation_p.E82K|ILF3_uc002mpo.2_Missense_Mutation_p.E484K|ILF3_uc002mpp.2_Missense_Mutation_p.E305K	NM_012218	NP_036350	Q12906	ILF3_HUMAN	interleukin enhancer binding factor 3 isoform a	484					M phase|negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrion|nucleolus|ribonucleoprotein complex	DNA binding|double-stranded RNA binding|protein binding|protein binding			ovary(3)	3			Epithelial(33;6.86e-06)|all cancers(31;1.65e-05)			GGACTCGGCTGAGGAGACCGA	0.647		NaN											0	0	0	0.058154	0	9	33									
MAST1	22983	broad.mit.edu	37	19	12975882	12975882	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr19:12975882C>T	uc002mvm.2	+	14	1656	c.1528C>T	c.(1528-1530)CAC>TAC	p.H510Y		NM_014975	NP_055790	Q9Y2H9	MAST1_HUMAN	microtubule associated serine/threonine kinase	510	Protein kinase.				cytoskeleton organization|intracellular protein kinase cascade	cytoplasm|cytoskeleton|plasma membrane	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			ovary(3)|lung(2)|large_intestine(1)|skin(1)	7						CTCCATGGGTCACATCAAGCT	0.577		NaN											0	0	0	0.069234	0	9	82									
CYP4F11	57834	broad.mit.edu	37	19	16038102	16038102	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr19:16038102G>A	uc002nbu.2	-	5	481	c.445C>T	c.(445-447)CGG>TGG	p.R149W	CYP4F11_uc010eab.1_Missense_Mutation_p.R149W|CYP4F11_uc002nbt.2_Missense_Mutation_p.R149W	NM_001128932	NP_001122404	Q9HBI6	CP4FB_HUMAN	cytochrome P450 family 4 subfamily F polypeptide	149					inflammatory response|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	aromatase activity|electron carrier activity|heme binding			ovary(1)	1						GTCAACATCCGACGGTGGCGG	0.537		NaN											0	0	0	0.058154	0	10	131									
ZNF714	148206	broad.mit.edu	37	19	21300143	21300143	+	Missense_Mutation	SNP	G	G	C			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr19:21300143G>C	uc002npo.3	+	6	1036	c.676G>C	c.(676-678)GAG>CAG	p.E226Q	ZNF714_uc002npl.2_Missense_Mutation_p.E71Q|ZNF714_uc010ecp.1_Missense_Mutation_p.E177Q|ZNF714_uc002npn.2_RNA	NM_182515	NP_872321	Q96N38	ZN714_HUMAN	zinc finger protein 714	226					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						TCATACTGGAGAGAAACCCTA	0.408		NaN											0	0	0	0.014758	0	5	68									
RBM42	79171	broad.mit.edu	37	19	36128214	36128214	+	Silent	SNP	G	G	A			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr19:36128214G>A	uc002oan.2	+	9	1366	c.1290G>A	c.(1288-1290)AAG>AAA	p.K430K	RBM42_uc010eef.2_Silent_p.K376K|RBM42_uc002oao.2_Silent_p.K408K|RBM42_uc002oap.2_Silent_p.K400K|RBM42_uc002oaq.2_Silent_p.K401K|RBM42_uc010eeg.2_Intron	NM_024321	NP_077297	Q9BTD8	RBM42_HUMAN	RNA binding motif protein 42	430	Necessary for interaction with HNRNPK (By similarity).|RRM.					cytoplasm|nucleus	nucleotide binding|RNA binding				0	all_lung(56;1.58e-07)|Lung NSC(56;2.43e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0724)			TCAGCTTCAAGGACCCCAGCG	0.647		NaN											0	0	0	0.139131	0	91	112									
ZNF569	148266	broad.mit.edu	37	19	37916855	37916855	+	Silent	SNP	G	G	A			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr19:37916855G>A	uc002ogi.2	-	5	711	c.153C>T	c.(151-153)TTC>TTT	p.F51F	ZNF569_uc002ogh.2_Intron|ZNF569_uc002ogj.2_Silent_p.F75F	NM_152484	NP_689697	Q5MCW4	ZN569_HUMAN	zinc finger protein 569	51	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|skin(1)	3			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			CAGGTTTGGTGAACGGATAGC	0.443		NaN											0	0	0	0.139131	0	58	774									
MEGF8	1954	broad.mit.edu	37	19	42873014	42873014	+	Silent	SNP	G	G	A	rs145990797		TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr19:42873014G>A	uc002otl.3	+	36	6935	c.6300G>A	c.(6298-6300)CCG>CCA	p.P2100P	MEGF8_uc002otm.3_Silent_p.P1708P|MEGF8_uc002otn.3_5'Flank	NM_001410	NP_001401	Q7Z7M0	MEGF8_HUMAN	multiple EGF-like-domains 8	2167	Extracellular (Potential).|PSI 7.					integral to membrane	calcium ion binding|structural molecule activity			ovary(1)	1		Prostate(69;0.00682)				GTGGGCGTCCGGGGGCCTCCT	0.642		NaN											0	0	0	0.139131	0	68	31									
PSG6	5675	broad.mit.edu	37	19	43585239	43585239	+	Missense_Mutation	SNP	A	A	T	rs142667584		TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr19:43585239A>T	uc002ovi.2	-	2	317	c.224T>A	c.(223-225)CTC>CAC	p.L75H	PSG6_uc010xwk.1_Intron|PSG2_uc002ovr.2_Missense_Mutation_p.L75H|PSG2_uc002ovq.3_Missense_Mutation_p.L75H|PSG2_uc010eiq.1_Missense_Mutation_p.L75H|PSG2_uc002ovs.3_Missense_Mutation_p.L75H|PSG2_uc002ovt.3_Missense_Mutation_p.L75H			Q00889	PSG6_HUMAN	SubName: Full=Putative uncharacterized protein PSG6;	75	Ig-like V-type.				female pregnancy	extracellular region				ovary(1)|skin(1)	2		Prostate(69;0.00899)				GTAATGGTAGAGGTCCCTGAT	0.433		NaN											0	0	0	0.11126	0	33	346									
XRCC1	7515	broad.mit.edu	37	19	44057007	44057007	+	Missense_Mutation	SNP	C	C	G			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr19:44057007C>G	uc002owt.2	-	8	885	c.765G>C	c.(763-765)AAG>AAC	p.K255N	XRCC1_uc010xwp.1_Missense_Mutation_p.K224N	NM_006297	NP_006288	P18887	XRCC1_HUMAN	X-ray repair cross complementing protein 1	255					base-excision repair|single strand break repair	nucleoplasm	damaged DNA binding|protein binding			ovary(2)|lung(2)|large_intestine(1)|prostate(1)|breast(1)	7		Prostate(69;0.0153)				TGGGGGTCTTCTTTTCTTCTT	0.498		NaN						Other_BER_factors					0	0	0	0.115264	0	3	43									
NANOS2	339345	broad.mit.edu	37	19	46417599	46417599	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr19:46417599C>T	uc002pdu.2	-	1	438	c.353G>A	c.(352-354)GGT>GAT	p.G118D		NM_001029861	NP_001025032	P60321	NANO2_HUMAN	nanos homolog 2	118					germ-line stem cell maintenance|mRNA catabolic process|multicellular organismal development|negative regulation of meiosis|regulation of translation|spermatogenesis	cytoplasmic mRNA processing body|perinuclear region of cytoplasm	RNA binding|zinc ion binding				0		Ovarian(192;0.0308)|all_neural(266;0.0476)		OV - Ovarian serous cystadenocarcinoma(262;0.00442)|GBM - Glioblastoma multiforme(486;0.0668)|Epithelial(262;0.231)		CTGCTGGCCACCGTTAAGCGG	0.672		NaN											0	0	0	0.055883	0	21	23									
SAE1	10055	broad.mit.edu	37	19	47706939	47706939	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr19:47706939C>T	uc002pgc.2	+	8	946	c.890C>T	c.(889-891)TCC>TTC	p.S297F	SAE1_uc002pgd.2_Missense_Mutation_p.P249S|SAE1_uc010ekx.2_Intron|SAE1_uc010ekw.2_RNA|SAE1_uc010xyk.1_Missense_Mutation_p.S123F|SAE1_uc002pge.2_Missense_Mutation_p.S233F	NM_016402	NP_057486	Q9UBE0	SAE1_HUMAN	SubName: Full=SUMO-1 activating enzyme subunit 1, isoform CRA_b; SubName: Full=cDNA, FLJ96708, Homo sapiens SUMO-1 activating enzyme subunit 1 (SAE1), mRNA;	297					protein sumoylation|protein ubiquitination	nucleus	ATP-dependent protein binding|enzyme activator activity|ligase activity|protein C-terminus binding|protein heterodimerization activity|ubiquitin activating enzyme activity			ovary(1)	1		all_cancers(25;1.13e-05)|all_lung(116;0.000192)|all_epithelial(76;0.000274)|Lung NSC(112;0.000446)|all_neural(266;0.0652)|Ovarian(192;0.15)		all cancers(93;0.00013)|OV - Ovarian serous cystadenocarcinoma(262;0.000146)|Epithelial(262;0.00697)|GBM - Glioblastoma multiforme(486;0.0278)		TACTGCTTCTCCGAGATGGCC	0.463		NaN											0	0	0	0.139131	0	78	42									
MEIS3	56917	broad.mit.edu	37	19	47910626	47910626	+	Silent	SNP	G	G	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr19:47910626G>T	uc002pgu.2	-	9	1365	c.918C>A	c.(916-918)ATC>ATA	p.I306I	MEIS3_uc010xyp.1_RNA|MEIS3_uc002pgo.2_Silent_p.I105I|MEIS3_uc002pgp.2_Silent_p.I138I|MEIS3_uc002pgq.2_Silent_p.I387I|MEIS3_uc002pgr.2_Silent_p.I174I|MEIS3_uc002pgt.2_Silent_p.I289I|MEIS3_uc002pgv.2_Silent_p.I335I|MEIS3_uc002pgs.2_Silent_p.I352I|MEIS3_uc010eld.2_Silent_p.I352I	NM_001009813	NP_001009813	Q99687	MEIS3_HUMAN	Meis1, myeloid ecotropic viral integration site	306	Homeobox; TALE-type.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0		all_cancers(25;1.65e-09)|all_epithelial(76;9.95e-08)|all_lung(116;7.27e-07)|Lung NSC(112;1.6e-06)|Ovarian(192;0.0139)|all_neural(266;0.026)|Breast(70;0.0503)		all cancers(93;0.000198)|OV - Ovarian serous cystadenocarcinoma(262;0.000439)|Epithelial(262;0.0113)|GBM - Glioblastoma multiforme(486;0.0223)		TGACTTGCAGGATGGTGAGCC	0.597		NaN											1	0	3.95532e-38	0.139131	4.38408e-38	59	29									
SCAF1	58506	broad.mit.edu	37	19	50154733	50154733	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr19:50154733C>T	uc002poq.2	+	7	1211	c.1087C>T	c.(1087-1089)CGG>TGG	p.R363W		NM_021228	NP_067051	Q9H7N4	SFR19_HUMAN	SR-related CTD-associated factor 1	363					mRNA processing|RNA splicing	nucleus	RNA binding				0		all_lung(116;1.05e-05)|Lung NSC(112;3.77e-05)|all_neural(266;0.196)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.00113)|GBM - Glioblastoma multiforme(134;0.0204)		AGAGGCTTGTCGGGAAGGCAA	0.721		NaN											0	0	0	0.021553	0	4	7									
C19orf51	352909	broad.mit.edu	37	19	55676784	55676784	+	Silent	SNP	C	C	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr19:55676784C>T	uc002qji.1	-	4	310	c.276G>A	c.(274-276)CTG>CTA	p.L92L	C19orf51_uc002qjj.1_Silent_p.L139L|C19orf51_uc002qjk.1_Silent_p.L38L|C19orf51_uc002qjl.1_Silent_p.L160L			Q8N9W5	CS051_HUMAN	RecName: Full=UPF0470 protein C19orf51;	92											0			BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.044)		GGCTGAAGATCAGCATGTGTC	0.547		NaN											0	0	0	0.139131	0	43	21									
TMEM150B	284417	broad.mit.edu	37	19	55831502	55831502	+	Missense_Mutation	SNP	G	G	A	rs61737281	by1000genomes	TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr19:55831502G>A	uc010esw.1	-	6	402	c.229C>T	c.(229-231)CTC>TTC	p.L77F	TMEM150B_uc010yfu.1_Missense_Mutation_p.L77F|TMEM150B_uc010yfv.1_RNA|TMEM150B_uc010yfw.1_RNA|TMEM150B_uc002qki.2_Missense_Mutation_p.L77F	NM_001085488	NP_001078957	A6NC51	T150B_HUMAN	transmembrane protein 150B precursor	77	Cytoplasmic (Potential).					integral to membrane					0						CAGTCCCGGAGCTGGTGGTAA	0.612		NaN											0	0	0	0.021553	0	5	149									
NLRP4	147945	broad.mit.edu	37	19	56392885	56392885	+	Missense_Mutation	SNP	G	G	C			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr19:56392885G>C	uc002qmd.3	+	10	3339	c.2917G>C	c.(2917-2919)GAG>CAG	p.E973Q	NLRP4_uc002qmf.2_Missense_Mutation_p.E898Q|NLRP4_uc010etf.2_Missense_Mutation_p.E748Q	NM_134444	NP_604393	Q96MN2	NALP4_HUMAN	NLR family, pyrin domain containing 4	973							ATP binding			ovary(5)|skin(4)|lung(3)|upper_aerodigestive_tract(1)|kidney(1)|pancreas(1)	15		Colorectal(82;0.0002)|Ovarian(87;0.221)		GBM - Glioblastoma multiforme(193;0.0606)		TCTGACGGCTGAGGAAGAGAG	0.433		NaN											0	0	0	0.144211	0	32	21									
PEG3	5178	broad.mit.edu	37	19	57327167	57327167	+	Silent	SNP	A	A	G			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr19:57327167A>G	uc002qnu.2	-	7	2994	c.2643T>C	c.(2641-2643)CCT>CCC	p.P881P	ZIM2_uc010ygq.1_Intron|ZIM2_uc010ygr.1_Intron|ZIM2_uc002qnr.2_Intron|ZIM2_uc002qnq.2_Intron|ZIM2_uc010etp.2_Intron|ZIM2_uc010ygs.1_Intron|PEG3_uc002qnt.2_Silent_p.P852P|PEG3_uc002qnv.2_Silent_p.P881P|PEG3_uc002qnw.2_Silent_p.P757P|PEG3_uc002qnx.2_Silent_p.P755P|PEG3_uc010etr.2_Silent_p.P881P	NM_001146186	NP_001139658	Q9GZU2	PEG3_HUMAN	paternally expressed 3 isoform 1	881					apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)		CCCCTTCACAAGGGTTCTCTC	0.443		NaN											0	0	0	0.069288	0	24	110									
ZNF587	84914	broad.mit.edu	37	19	58371262	58371262	+	Silent	SNP	C	C	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr19:58371262C>T	uc002qql.2	+	3	1620	c.1482C>T	c.(1480-1482)TGC>TGT	p.C494C	ZNF587_uc002qqb.2_Silent_p.C451C|ZNF587_uc010yhh.1_Silent_p.C451C|ZNF587_uc002qqi.1_Silent_p.C451C|ZNF587_uc002qqj.1_RNA|ZNF814_uc002qqk.2_Intron|ZNF587_uc010yhk.1_Silent_p.C493C	NM_032828	NP_116217	Q96SQ5	ZN587_HUMAN	zinc finger protein 587	494	C2H2-type 11.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Colorectal(82;0.000256)|all_neural(62;0.0577)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0264)		CGTATGAATGCAGTGAATGTG	0.413		NaN											0	0	0	0.104719	0	42	230									
ZNF814	730051	broad.mit.edu	37	19	58385762	58385762	+	Silent	SNP	C	C	G			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr19:58385762C>G	uc002qqo.2	-	3	1268	c.996G>C	c.(994-996)TCG>TCC	p.S332S	ZNF814_uc002qqk.2_Intron|ZNF814_uc010yhl.1_Intron	NM_001144989	NP_001138461	B7Z6K7	ZN814_HUMAN	zinc finger protein 814	332	C2H2-type 5.				regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding				0						ATTTGCTAAACGATTTCCCAC	0.358		NaN											0	0	0	0.115264	0	2	12									
ZFP36L2	678	broad.mit.edu	37	2	43452168	43452168	+	Missense_Mutation	SNP	T	T	C			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr2:43452168T>C	uc002rsv.3	-	2	1066	c.775A>G	c.(775-777)AGC>GGC	p.S259G	LOC100129726_uc010ynx.1_5'Flank	NM_006887	NP_008818	P47974	TISD_HUMAN	zinc finger protein 36, C3H type-like 2	259					cell proliferation	nucleus	DNA binding|RNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Acute lymphoblastic leukemia(82;0.00323)|all_hematologic(82;0.00824)				CCCGAGAAGCTGAGGCTGTGG	0.682		NaN											0	0	0	0.038147	0	7	12									
DUSP11	8446	broad.mit.edu	37	2	73993695	73993695	+	Nonsense_Mutation	SNP	G	G	C			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr2:73993695G>C	uc002sjp.2	-	8	827	c.785C>G	c.(784-786)TCA>TGA	p.S262*		NM_003584	NP_003575	O75319	DUS11_HUMAN	dual specificity phosphatase 11	215					RNA processing	nucleus	protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity|RNA binding			skin(1)	1						AAAATCACTTGACCTGGGTAC	0.378		NaN											0	0	0	0.139131	0	74	43									
SUCLG1	8802	broad.mit.edu	37	2	84670479	84670479	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr2:84670479C>T	uc002son.2	-	3	440	c.247G>A	c.(247-249)GTT>ATT	p.V83I	SUCLG1_uc010ysk.1_Missense_Mutation_p.V70I	NM_003849	NP_003840	P53597	SUCA_HUMAN	succinate-CoA ligase, GDP-forming alpha subunit	83					tricarboxylic acid cycle		ATP citrate synthase activity|GTP binding|succinate-CoA ligase (GDP-forming) activity				0					Succinic acid(DB00139)	GTTCCTCCAACGAGTTTGGTG	0.498		NaN											0	0	0	0.139131	0	47	29									
AFF3	3899	broad.mit.edu	37	2	100209756	100209756	+	Missense_Mutation	SNP	C	C	G			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr2:100209756C>G	uc002tag.2	-	14	2603	c.2367G>C	c.(2365-2367)TTG>TTC	p.L789F	AFF3_uc002taf.2_Missense_Mutation_p.L814F|AFF3_uc010fiq.1_Missense_Mutation_p.L789F|AFF3_uc010yvr.1_Missense_Mutation_p.L942F|AFF3_uc002tah.1_Missense_Mutation_p.L814F	NM_002285	NP_002276	P51826	AFF3_HUMAN	AF4/FMR2 family, member 3 isoform 1	789					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(2)|pancreas(1)|lung(1)|kidney(1)|skin(1)	6						CAGGGGCGCTCAATACCCCTG	0.577		NaN											0	0	0	0.069288	0	22	40									
SLC5A7	60482	broad.mit.edu	37	2	108626840	108626840	+	Silent	SNP	T	T	C			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr2:108626840T>C	uc002tdv.2	+	9	1542	c.1266T>C	c.(1264-1266)CTT>CTC	p.L422L	SLC5A7_uc010ywm.1_Silent_p.L175L|SLC5A7_uc010fjj.2_Silent_p.L422L|SLC5A7_uc010ywn.1_Silent_p.L309L	NM_021815	NP_068587	Q9GZV3	SC5A7_HUMAN	solute carrier family 5 (choline transporter),	422	Helical; (Potential).				acetylcholine biosynthetic process|neurotransmitter secretion	integral to membrane|plasma membrane	choline:sodium symporter activity			ovary(2)|central_nervous_system(1)|skin(1)	4					Choline(DB00122)	CCCAGCTGCTTTGTGTACTCT	0.498		NaN											0	0	0	0.139131	0	53	45									
IWS1	55677	broad.mit.edu	37	2	128253576	128253576	+	Missense_Mutation	SNP	C	C	G			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr2:128253576C>G	uc002ton.2	-	7	2017	c.1714G>C	c.(1714-1716)GAG>CAG	p.E572Q	IWS1_uc010yzl.1_RNA	NM_017969	NP_060439	Q96ST2	IWS1_HUMAN	IWS1 homolog	572					transcription, DNA-dependent	nucleus	DNA binding			ovary(1)	1	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0735)		CAGCTCACCTCAGCAGCTTCA	0.468		NaN											0	0	0	0.139131	0	119	85									
XIRP2	129446	broad.mit.edu	37	2	168100730	168100730	+	Missense_Mutation	SNP	G	G	C			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr2:168100730G>C	uc002udx.2	+	8	2846	c.2828G>C	c.(2827-2829)GGA>GCA	p.G943A	XIRP2_uc010fpn.2_Intron|XIRP2_uc010fpo.2_Intron|XIRP2_uc010fpp.2_Intron|XIRP2_uc002udy.2_Missense_Mutation_p.G768A|XIRP2_uc010fpq.2_Missense_Mutation_p.G721A|XIRP2_uc010fpr.2_Intron	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	768	Xin 12.				actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14						GTTGACAGAGGAGATGTGAAG	0.343		NaN											0	0	0	0.134883	0	32	36									
MYO3B	140469	broad.mit.edu	37	2	171356164	171356164	+	Silent	SNP	C	C	G			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr2:171356164C>G	uc002ufy.2	+	27	3278	c.3135C>G	c.(3133-3135)CTC>CTG	p.L1045L	MYO3B_uc002ufv.2_Silent_p.L1032L|MYO3B_uc010fqb.1_Silent_p.L1032L|MYO3B_uc002ufz.2_Silent_p.L1045L|MYO3B_uc002ufw.2_RNA|MYO3B_uc002ufx.2_RNA|MYO3B_uc002ugb.2_Intron	NM_138995	NP_620482	Q8WXR4	MYO3B_HUMAN	myosin IIIB isoform 2	1045	Myosin head-like.				response to stimulus|visual perception	cytoplasm|myosin complex	actin binding|ATP binding|motor activity|protein serine/threonine kinase activity			lung(8)|ovary(6)|skin(4)|central_nervous_system(1)	19						AGGTTTTTCTCAAATATTACC	0.388		NaN											0	0	0	0.069234	0	9	60									
INO80D	54891	broad.mit.edu	37	2	206869542	206869542	+	Silent	SNP	C	C	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr2:206869542C>T	uc002vaz.3	-	11	3039	c.2634G>A	c.(2632-2634)GTG>GTA	p.V878V		NM_017759	NP_060229	Q53TQ3	IN80D_HUMAN	INO80 complex subunit D	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					DNA recombination|DNA repair|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				ovary(1)	1						CTCCAAGTGGCACCTCAAGTT	0.547		NaN											0	0	0	0.055883	0	21	35									
INPP5D	3635	broad.mit.edu	37	2	234079249	234079249	+	Silent	SNP	C	C	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr2:234079249C>T	uc010zmo.1	+	15	2052	c.1899C>T	c.(1897-1899)TTC>TTT	p.F633F	INPP5D_uc010zmp.1_Silent_p.F632F	NM_001017915	NP_001017915	Q92835	SHIP1_HUMAN	SH2 containing inositol phosphatase isoform a	633					apoptosis|blood coagulation|leukocyte migration|T cell receptor signaling pathway	cytosol	inositol-polyphosphate 5-phosphatase activity|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|SH3 domain binding			ovary(1)|central_nervous_system(1)	2		Breast(86;0.0013)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0273)|Acute lymphoblastic leukemia(138;0.0328)|Lung NSC(271;0.0843)		Epithelial(121;1.16e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000479)|LUSC - Lung squamous cell carcinoma(224;0.00655)|Lung(119;0.00802)|GBM - Glioblastoma multiforme(43;0.0185)		TCCTACACTTCGGTAAGAGCA	0.323		NaN											0	0	0	0.132662	0	16	18									
COL6A3	1293	broad.mit.edu	37	2	238277740	238277740	+	Nonsense_Mutation	SNP	G	G	A			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr2:238277740G>A	uc002vwl.2	-	10	4651	c.4366C>T	c.(4366-4368)CGA>TGA	p.R1456*	COL6A3_uc002vwo.2_Nonsense_Mutation_p.R1250*|COL6A3_uc010znj.1_Nonsense_Mutation_p.R849*	NM_004369	NP_004360	P12111	CO6A3_HUMAN	alpha 3 type VI collagen isoform 1 precursor	1456	VWFA 8.|Nonhelical region.				axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			ovary(8)|central_nervous_system(6)|skin(2)|upper_aerodigestive_tract(1)|pancreas(1)	18		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		ACAAAATCTCGAATATGTGCA	0.458		NaN											0	0	0	0.055883	0	21	15									
RBCK1	10616	broad.mit.edu	37	20	390664	390664	+	Silent	SNP	C	C	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr20:390664C>T	uc002wdp.3	+	2	855	c.162C>T	c.(160-162)GAC>GAT	p.D54D	RBCK1_uc010zpl.1_Silent_p.D54D|RBCK1_uc010zpm.1_RNA|RBCK1_uc002wdq.3_Intron|RBCK1_uc010fzy.2_RNA|RBCK1_uc002wdr.3_Intron|RBCK1_uc002wdo.2_RNA	NM_031229	NP_112506	Q9BYM8	HOIL1_HUMAN	RanBP-type and C3HC4-type zinc finger containing	54	Interaction with IRF3.|Interaction with TAB2.				interspecies interaction between organisms|negative regulation of NF-kappaB transcription factor activity|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|proteasomal ubiquitin-dependent protein catabolic process|protein linear polyubiquitination|T cell receptor signaling pathway	LUBAC complex	protein binding|ubiquitin binding|ubiquitin-protein ligase activity|zinc ion binding				0		all_epithelial(17;0.172)|Lung NSC(37;0.191)|Breast(17;0.231)				CAACGCAGGACATCAGGTGAG	0.517		NaN											0	0	0	0.076483	0	24	41									
BFSP1	631	broad.mit.edu	37	20	17492687	17492687	+	Missense_Mutation	SNP	G	G	C			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr20:17492687G>C	uc002wpo.2	-	4	600	c.561C>G	c.(559-561)ATC>ATG	p.I187M	BFSP1_uc002wpp.2_Missense_Mutation_p.I62M|BFSP1_uc010zrn.1_Missense_Mutation_p.I48M|BFSP1_uc010zro.1_Missense_Mutation_p.I48M	NM_001195	NP_001186	Q12934	BFSP1_HUMAN	filensin isoform 1	187	Rod.|Linker 12.					cytoplasm|intermediate filament|membrane	structural constituent of cytoskeleton|structural constituent of eye lens			central_nervous_system(1)	1						GCAGGATGCTGATATAGGTCT	0.473		NaN											0	0	0	0.038395	0	17	62									
TMEM90B	79953	broad.mit.edu	37	20	24524190	24524190	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr20:24524190G>A	uc002wtw.1	+	2	1090	c.457G>A	c.(457-459)GAG>AAG	p.E153K		NM_024893	NP_079169	Q9H7V2	SYNG1_HUMAN	transmembrane protein 90B	153	Poly-Glu.|Cytoplasmic (Potential).				response to biotic stimulus	early endosome membrane|integral to membrane|plasma membrane					0						TGTGGAGGAGGAGGAGGAGTT	0.542		NaN											0	0	0	0.139131	0	44	114									
KIAA1755	85449	broad.mit.edu	37	20	36870149	36870149	+	Silent	SNP	G	G	C			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr20:36870149G>C	uc002xhy.1	-	3	656	c.384C>G	c.(382-384)CTC>CTG	p.L128L	KIAA1755_uc002xhz.1_Silent_p.L128L	NM_001029864	NP_001025035	Q5JYT7	K1755_HUMAN	hypothetical protein LOC85449	128										ovary(4)|pancreas(1)	5		Myeloproliferative disorder(115;0.00874)				CCACTGTGCAGAGGTCCAGGG	0.537		NaN											0	0	0	0.11126	0	42	135									
PPP1R16B	26051	broad.mit.edu	37	20	37547022	37547022	+	Missense_Mutation	SNP	A	A	C	rs61752055	byFrequency	TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr20:37547022A>C	uc002xje.2	+	11	1606	c.1417A>C	c.(1417-1419)AAG>CAG	p.K473Q	PPP1R16B_uc010ggc.2_Missense_Mutation_p.K431Q	NM_015568	NP_056383	Q96T49	PP16B_HUMAN	protein phosphatase 1 regulatory inhibitor	473					regulation of filopodium assembly|signal transduction	nucleus|plasma membrane	protein phosphatase binding	p.K473Q(1)		upper_aerodigestive_tract(1)|kidney(1)|skin(1)	3		Myeloproliferative disorder(115;0.00878)				GAGCAGCTACAAGGAACAGAG	0.642		NaN											0	0	0	0.014758	0	5	122									
SLC12A5	57468	broad.mit.edu	37	20	44676189	44676189	+	Missense_Mutation	SNP	C	C	G			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr20:44676189C>G	uc010zxl.1	+	15	2029	c.1953C>G	c.(1951-1953)ATC>ATG	p.I651M	SLC12A5_uc010zxm.1_RNA|SLC12A5_uc002xrb.2_Missense_Mutation_p.I628M	NM_001134771	NP_001128243	Q9H2X9	S12A5_HUMAN	solute carrier family 12 (potassium-chloride	651	Helical; (Potential).				potassium ion transport|sodium ion transport	integral to membrane	potassium:chloride symporter activity			ovary(2)|large_intestine(1)|central_nervous_system(1)|skin(1)	5		Myeloproliferative disorder(115;0.0122)			Bumetanide(DB00887)|Potassium Chloride(DB00761)	CTGGACTCATCTACAAGTACA	0.318		NaN											0	0	0	0.043863	0	18	156									
SLC12A5	57468	broad.mit.edu	37	20	44676672	44676672	+	Missense_Mutation	SNP	C	C	G			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr20:44676672C>G	uc010zxl.1	+	16	2105	c.2029C>G	c.(2029-2031)CGC>GGC	p.R677G	SLC12A5_uc010zxm.1_RNA|SLC12A5_uc002xrb.2_Missense_Mutation_p.R654G	NM_001134771	NP_001128243	Q9H2X9	S12A5_HUMAN	solute carrier family 12 (potassium-chloride	677					potassium ion transport|sodium ion transport	integral to membrane	potassium:chloride symporter activity			ovary(2)|large_intestine(1)|central_nervous_system(1)|skin(1)	5		Myeloproliferative disorder(115;0.0122)			Bumetanide(DB00887)|Potassium Chloride(DB00761)	CAGTGCGGCTCGCTATGCCCT	0.602		NaN											0	0	0	0.009096	0	4	17									
CDH22	64405	broad.mit.edu	37	20	44806753	44806753	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr20:44806753C>T	uc002xrm.2	-	10	2148	c.1747G>A	c.(1747-1749)GAC>AAC	p.D583N	CDH22_uc010ghk.1_Missense_Mutation_p.D583N	NM_021248	NP_067071	Q9UJ99	CAD22_HUMAN	cadherin 22 precursor	583	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|skin(1)	5		Myeloproliferative disorder(115;0.0122)				GGCCCACTGTCTACCACCAGG	0.632		NaN											0	0	0	0.021553	0	6	37									
ZNF831	128611	broad.mit.edu	37	20	57767194	57767194	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr20:57767194G>A	uc002yan.2	+	1	1120	c.1120G>A	c.(1120-1122)GAG>AAG	p.E374K		NM_178457	NP_848552	Q5JPB2	ZN831_HUMAN	zinc finger protein 831	374						intracellular	nucleic acid binding|zinc ion binding			skin(13)|ovary(1)	14	all_lung(29;0.0085)					CGCCGAGTCCGAGGGGGAggg	0.527		NaN											0	0	0	0.02938	0	6	12									
CDH4	1002	broad.mit.edu	37	20	60511869	60511869	+	Silent	SNP	C	C	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr20:60511869C>T	uc002ybn.1	+	16	2633	c.2619C>T	c.(2617-2619)AGC>AGT	p.S873S	CDH4_uc002ybp.1_Silent_p.S799S|uc002ybr.1_5'Flank	NM_001794	NP_001785	P55283	CADH4_HUMAN	cadherin 4, type 1 preproprotein	873	Ser-rich.|Cytoplasmic (Potential).				adherens junction organization|cell junction assembly		calcium ion binding			lung(3)|ovary(2)|skin(1)	6			BRCA - Breast invasive adenocarcinoma(19;2.36e-08)			ACGAGGGGAGCGGCTCCACCG	0.622		NaN											0	0	0	0.02938	0	7	48									
EEF1A2	1917	broad.mit.edu	37	20	62121972	62121972	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr20:62121972C>T	uc002yfd.1	-	5	990	c.889G>A	c.(889-891)GAG>AAG	p.E297K	EEF1A2_uc002yfe.1_Missense_Mutation_p.E297K|EEF1A2_uc010gkg.1_Missense_Mutation_p.E297K	NM_001958	NP_001949	Q05639	EF1A2_HUMAN	eukaryotic translation elongation factor 1 alpha	297						nucleus	GTP binding|GTPase activity|protein binding|translation elongation factor activity				0	all_cancers(38;9.45e-12)		BRCA - Breast invasive adenocarcinoma(10;1.22e-05)			CTCAGAGCCTCGTGGTGCATC	0.627		NaN											0	0	0	0.092188	0	38	104									
GRIK1	2897	broad.mit.edu	37	21	31062135	31062135	+	Missense_Mutation	SNP	C	C	A			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr21:31062135C>A	uc002yno.1	-	3	921	c.457G>T	c.(457-459)GAT>TAT	p.D153Y	GRIK1_uc002ynn.2_Missense_Mutation_p.D153Y|GRIK1_uc011acs.1_Missense_Mutation_p.D153Y|GRIK1_uc011act.1_Missense_Mutation_p.D97Y|GRIK1_uc010glq.1_Intron|GRIK1_uc002ynr.2_Missense_Mutation_p.D153Y	NM_000830	NP_000821	P39086	GRIK1_HUMAN	glutamate receptor, ionotropic, kainate 1	153	Extracellular (Potential).				central nervous system development|synaptic transmission	cell junction|postsynaptic membrane	kainate selective glutamate receptor activity			large_intestine(1)|ovary(1)|skin(1)	3					L-Glutamic Acid(DB00142)|Topiramate(DB00273)	GCTGCATAATCTGGGTAAAGG	0.473		NaN											1	0	3.90494e-43	0.139131	4.35183e-43	90	140									
RUNX1	861	broad.mit.edu	37	21	36206817	36206817	+	Missense_Mutation	SNP	C	C	A			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr21:36206817C>A	uc002yuh.2	-	4	2192	c.614G>T	c.(613-615)CGG>CTG	p.R205L	RUNX1_uc002yui.2_Intron|RUNX1_uc010gmu.2_Missense_Mutation_p.R232L|RUNX1_uc010gmv.2_Missense_Mutation_p.R232L|RUNX1_uc002yuj.3_Missense_Mutation_p.R100L|RUNX1_uc002yuk.3_Missense_Mutation_p.R232L|RUNX1_uc002yul.1_5'UTR|RUNX1_uc002yum.1_Intron|RUNX1_uc010gmw.1_Missense_Mutation_p.R232L|RUNX1_uc002yuo.1_Missense_Mutation_p.R205L	NM_001001890	NP_001001890	Q01196	RUNX1_HUMAN	runt-related transcription factor 1 isoform	205	Pro/Ser/Thr-rich.			Missing: No DNA-binding.	myeloid cell differentiation|negative regulation of granulocyte differentiation|positive regulation of angiogenesis|positive regulation of granulocyte differentiation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent	nucleus|nucleus	ATP binding|calcium ion binding|DNA binding|DNA binding|protein binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|sequence-specific DNA binding transcription factor activity|transcription factor binding			haematopoietic_and_lymphoid_tissue(383)|lung(2)|ovary(1)|central_nervous_system(1)	387						GGCTGTGCGCCGCAGCTGCTC	0.597		NaN	T	RPL22|MDS1|EVI1|CBFA2T3|CBFA2T1|ETV6|LAF4	AML|preB- ALL|T-ALL				Platelet_disorder_associated_with_Myeloid_Malignancies				1	0	7.73544e-29	0.139131	8.50483e-29	59	45									
DSCAM	1826	broad.mit.edu	37	21	41465774	41465774	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr21:41465774C>T	uc002yyq.1	-	21	4176	c.3724G>A	c.(3724-3726)GAC>AAC	p.D1242N	DSCAM_uc002yyr.1_RNA	NM_001389	NP_001380	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule isoform	1242	Fibronectin type-III 4.|Extracellular (Potential).				cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			ovary(6)|skin(4)|upper_aerodigestive_tract(1)	11		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				GAAAACGAGTCGGGAGAGGCC	0.478		NaN											0	0	0	0.069288	0	21	41									
PCNT	5116	broad.mit.edu	37	21	47809235	47809235	+	Silent	SNP	C	C	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr21:47809235C>T	uc002zji.3	+	19	3836	c.3729C>T	c.(3727-3729)CTC>CTT	p.L1243L	PCNT_uc002zjj.2_Silent_p.L1125L	NM_006031	NP_006022	O95613	PCNT_HUMAN	pericentrin	1243					cilium assembly|G2/M transition of mitotic cell cycle	cytosol|microtubule	calmodulin binding			ovary(4)|breast(2)|pancreas(2)	8	Breast(49;0.112)					AAAGCTTTCTCATGAGCCCAG	0.577		NaN											0	0	0	0.059317	0	31	83									
SUSD2	56241	broad.mit.edu	37	22	24579560	24579560	+	Missense_Mutation	SNP	A	A	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr22:24579560A>T	uc002zzn.1	+	3	429	c.385A>T	c.(385-387)ACT>TCT	p.T129S		NM_019601	NP_062547	Q9UGT4	SUSD2_HUMAN	sushi domain containing 2 precursor	129	Extracellular (Potential).				immune response	integral to membrane	polysaccharide binding|protein binding|scavenger receptor activity			skin(1)	1						CATCCCCTTCACTGTGTCACT	0.642		NaN											0	0	0	0.139131	0	45	30									
EMID1	129080	broad.mit.edu	37	22	29628275	29628275	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr22:29628275G>A	uc003aen.2	+	8	776	c.701G>A	c.(700-702)CGG>CAG	p.R234Q	EMID1_uc003aem.2_Missense_Mutation_p.R236Q|EMID1_uc003aeo.2_Missense_Mutation_p.R236Q|EMID1_uc003aep.2_Missense_Mutation_p.R236Q	NM_133455	NP_597712	Q96A84	EMID1_HUMAN	EMI domain containing 1	234	Collagen-like.					collagen					0						AGCCCTGGCCGGGCTGGAGCT	0.701		NaN											0	0	0	0.134883	0	31	25									
PLCL2	23228	broad.mit.edu	37	3	17051752	17051752	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr3:17051752C>T	uc011awc.1	+	5	995	c.890C>T	c.(889-891)ACG>ATG	p.T297M	PLCL2_uc010het.1_Intron|PLCL2_uc011awd.1_Missense_Mutation_p.T179M	NM_001144382	NP_001137854	Q9UPR0	PLCL2_HUMAN	phospholipase C-like 2 isoform 1	305					intracellular signal transduction|lipid metabolic process	cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			skin(2)|ovary(1)|lung(1)	4						GGTTTAAAAACGAGCAAAATT	0.348		NaN											0	0	0	0.125774	0	30	83									
NKTR	4820	broad.mit.edu	37	3	42679721	42679721	+	Missense_Mutation	SNP	G	G	C			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr3:42679721G>C	uc003clo.2	+	13	2672	c.2525G>C	c.(2524-2526)AGA>ACA	p.R842T	NKTR_uc003clm.1_Missense_Mutation_p.R589T|NKTR_uc003clp.2_Missense_Mutation_p.R589T|NKTR_uc011azp.1_Intron|NKTR_uc003clq.1_Missense_Mutation_p.R732T|NKTR_uc003clr.1_Missense_Mutation_p.R589T|NKTR_uc003cls.2_Missense_Mutation_p.R542T	NM_005385	NP_005376	P30414	NKTR_HUMAN	natural killer-tumor recognition sequence	842					protein folding	membrane	cyclosporin A binding|peptidyl-prolyl cis-trans isomerase activity			ovary(2)|skin(1)	3				KIRC - Kidney renal clear cell carcinoma(284;0.24)		GAAAAAAACAGAGGTGAAGAA	0.413		NaN											0	0	0	0.146539	0	14	50									
BSN	8927	broad.mit.edu	37	3	49698687	49698687	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr3:49698687G>A	uc003cxe.3	+	6	9523	c.9409G>A	c.(9409-9411)GAT>AAT	p.D3137N		NM_003458	NP_003449	Q9UPA5	BSN_HUMAN	bassoon protein	3137					synaptic transmission	cell junction|cytoplasm|cytoskeleton|nucleus|synaptosome	metal ion binding			ovary(5)|pancreas(1)|central_nervous_system(1)|skin(1)	8				BRCA - Breast invasive adenocarcinoma(193;6.66e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.0032)|Kidney(197;0.00336)		AGTCCCCGCTGATAGCCGTGC	0.622		NaN											0	0	0	0.038395	0	15	44									
IP6K1	9807	broad.mit.edu	37	3	49770248	49770248	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr3:49770248C>T	uc003cxm.1	-	4	907	c.592G>A	c.(592-594)GAG>AAG	p.E198K	IP6K1_uc003cxn.1_Missense_Mutation_p.E33K|IP6K1_uc011bcv.1_Missense_Mutation_p.E33K|IP6K1_uc003cxo.2_Missense_Mutation_p.E198K	NM_153273	NP_695005	Q92551	IP6K1_HUMAN	inositol hexakisphosphate kinase 1 isoform 1	198					phosphatidylinositol phosphorylation	cytoplasm|nucleus	ATP binding|inositol hexakisphosphate 5-kinase activity|inositol trisphosphate 3-kinase activity				0						TCCTTGGACTCGGAGCGCATG	0.567		NaN											0	0	0	0.038395	0	18	44									
ADAMTS9	56999	broad.mit.edu	37	3	64607948	64607948	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr3:64607948G>A	uc003dmg.2	-	18	2644	c.2612C>T	c.(2611-2613)CCA>CTA	p.P871L	ADAMTS9_uc011bfo.1_Missense_Mutation_p.P843L|ADAMTS9_uc003dmh.1_Missense_Mutation_p.P700L|ADAMTS9_uc003dmk.1_Missense_Mutation_p.P871L	NM_182920	NP_891550	Q9P2N4	ATS9_HUMAN	ADAM metallopeptidase with thrombospondin type 1	871	Spacer.				glycoprotein catabolic process|multicellular organismal development|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(2)|urinary_tract(1)|skin(1)	4		Lung NSC(201;0.00682)		BRCA - Breast invasive adenocarcinoma(55;0.00142)|Kidney(15;0.00202)|KIRC - Kidney renal clear cell carcinoma(15;0.00221)		ATCTTCAATTGGAATATTGAA	0.438		NaN											0	0	0	0.038395	0	18	47									
TOMM70A	9868	broad.mit.edu	37	3	100105732	100105732	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr3:100105732C>T	uc003dtw.2	-	2	847	c.415G>A	c.(415-417)GAG>AAG	p.E139K		NM_014820	NP_055635	O94826	TOM70_HUMAN	translocase of outer mitochondrial membrane 70	139	TPR 1.|Cytoplasmic (Potential).				protein targeting to mitochondrion	integral to membrane|mitochondrial outer membrane translocase complex	protein binding|protein transmembrane transporter activity			ovary(1)	1						CTAATAGCCTCAGTATAGCAC	0.383		NaN											0	0	0	0.069288	0	24	103									
ARHGAP31	57514	broad.mit.edu	37	3	119134233	119134233	+	Missense_Mutation	SNP	G	G	C			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr3:119134233G>C	uc003ecj.3	+	12	3989	c.3457G>C	c.(3457-3459)GAC>CAC	p.D1153H		NM_020754	NP_065805	Q2M1Z3	RHG31_HUMAN	Cdc42 GTPase-activating protein	1153					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|focal adhesion|lamellipodium	GTPase activator activity			ovary(2)	2						CTGTAAAGCAGACCCCTGGAG	0.537		NaN											0	0	0	0.105934	0	14	63									
PLS1	5357	broad.mit.edu	37	3	142403175	142403175	+	Missense_Mutation	SNP	G	G	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr3:142403175G>T	uc010huv.2	+	8	985	c.826G>T	c.(826-828)GTG>TTG	p.V276L	PLS1_uc003euz.2_Missense_Mutation_p.V276L|PLS1_uc003eva.2_Missense_Mutation_p.V276L	NM_001145319	NP_001138791	Q14651	PLSI_HUMAN	plastin 1	276	Actin-binding 1.|CH 2.					cytoplasm	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(1)	1						GCTGCGATGGGTGAACTACCA	0.413		NaN											1	0	5.39261e-20	0.139131	5.83486e-20	56	53									
MED12L	116931	broad.mit.edu	37	3	151112453	151112453	+	Missense_Mutation	SNP	G	G	C			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr3:151112453G>C	uc003eyp.2	+	37	5551	c.5513G>C	c.(5512-5514)AGA>ACA	p.R1838T	MED12L_uc011bnz.1_Missense_Mutation_p.R1698T	NM_053002	NP_443728	Q86YW9	MD12L_HUMAN	mediator of RNA polymerase II transcription,	1838					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	mediator complex				ovary(4)|large_intestine(1)|central_nervous_system(1)|skin(1)	7			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			GGTGGCTCCAGATTGGACCCT	0.463		NaN											0	0	0	0.11126	0	39	156									
RTP2	344892	broad.mit.edu	37	3	187419823	187419823	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr3:187419823C>T	uc003fro.1	-	1	523	c.94G>A	c.(94-96)GAC>AAC	p.D32N		NM_001004312	NP_001004312	Q5QGT7	RTP2_HUMAN	receptor transporting protein 2	32	Cytoplasmic (Potential).				protein insertion into membrane	cell surface|integral to membrane|plasma membrane	olfactory receptor binding				0	all_cancers(143;4.06e-12)|Ovarian(172;0.0418)		OV - Ovarian serous cystadenocarcinoma(80;1.76e-18)	GBM - Glioblastoma multiforme(93;0.0515)		AGGTTGGGGTCTATGATGAGC	0.577		NaN											0	0	0	0.092188	0	38	181									
SENP5	205564	broad.mit.edu	37	3	196612107	196612107	+	Missense_Mutation	SNP	G	G	C			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr3:196612107G>C	uc003fwz.3	+	2	304	c.55G>C	c.(55-57)GAG>CAG	p.E19Q	SENP5_uc011bty.1_Missense_Mutation_p.E19Q	NM_152699	NP_689912	Q96HI0	SENP5_HUMAN	SUMO1/sentrin specific peptidase 5	19					cell cycle|cell division|proteolysis	nucleolus	cysteine-type peptidase activity			breast(2)|lung(1)	3	all_cancers(143;1.8e-08)|Ovarian(172;0.0634)|Breast(254;0.135)		Epithelial(36;3.14e-24)|all cancers(36;2.1e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.03e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.004)		AGCCTTTTCTGAGAAATGGAA	0.383		NaN											0	0	0	0.076483	0	24	76									
LIMCH1	22998	broad.mit.edu	37	4	41668680	41668680	+	Missense_Mutation	SNP	C	C	G			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr4:41668680C>G	uc003gvu.3	+	16	2293	c.2239C>G	c.(2239-2241)CAA>GAA	p.Q747E	LIMCH1_uc003gvv.3_Missense_Mutation_p.Q747E|LIMCH1_uc003gvw.3_Missense_Mutation_p.Q747E|LIMCH1_uc003gvx.3_Missense_Mutation_p.Q735E|LIMCH1_uc003gwe.3_Intron|LIMCH1_uc003gvy.3_Missense_Mutation_p.Q576E|LIMCH1_uc003gwa.3_Missense_Mutation_p.Q588E|LIMCH1_uc003gvz.3_Missense_Mutation_p.Q1132E|LIMCH1_uc011byu.1_Missense_Mutation_p.Q581E|LIMCH1_uc003gwc.3_Missense_Mutation_p.Q593E|LIMCH1_uc003gwd.3_Missense_Mutation_p.Q581E|LIMCH1_uc011byv.1_Missense_Mutation_p.Q498E|LIMCH1_uc011byw.1_Missense_Mutation_p.Q47E	NM_014988	NP_055803	Q9UPQ0	LIMC1_HUMAN	LIM and calponin homology domains 1 isoform a	747					actomyosin structure organization		actin binding|zinc ion binding			ovary(2)|pancreas(1)|skin(1)	4						TCTCAATTCTCAAGGTAAAGA	0.393		NaN											0	0	0	0.058154	0	9	40									
GABRG1	2565	broad.mit.edu	37	4	46099350	46099350	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr4:46099350C>T	uc003gxb.2	-	2	273	c.121G>A	c.(121-123)GAT>AAT	p.D41N		NM_173536	NP_775807	Q8N1C3	GBRG1_HUMAN	gamma-aminobutyric acid A receptor, gamma 1	41	Extracellular (Probable).				gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity			ovary(2)	2				Lung(65;0.106)|LUSC - Lung squamous cell carcinoma(721;0.23)		TCATCTTCATCATCTGCCTTA	0.328		NaN											0	0	0	0.139131	0	60	58									
PRKG2	5593	broad.mit.edu	37	4	82126175	82126175	+	Silent	SNP	T	T	C			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr4:82126175T>C	uc003hmh.2	-	1	41	c.27A>G	c.(25-27)AAA>AAG	p.K9K	PRKG2_uc011cch.1_Silent_p.K9K	NM_006259	NP_006250	Q13237	KGP2_HUMAN	protein kinase, cGMP-dependent, type II	9					platelet activation|signal transduction	cytosol	ATP binding|cGMP binding|cGMP-dependent protein kinase activity			breast(3)|central_nervous_system(2)|ovary(1)|large_intestine(1)	7						GCTTAGAATGTTTAGGTTTCA	0.502		NaN											0	0	0	0.058154	0	10	40									
UBE2D3	7323	broad.mit.edu	37	4	103730859	103730859	+	Missense_Mutation	SNP	C	C	A			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr4:103730859C>A	uc003hwk.2	-	4	551	c.90G>T	c.(88-90)ATG>ATT	p.M30I	UBE2D3_uc003hwi.2_Missense_Mutation_p.M30I|UBE2D3_uc003hwj.2_RNA|UBE2D3_uc003hwl.2_Missense_Mutation_p.M30I|UBE2D3_uc011cet.1_Missense_Mutation_p.M30I|UBE2D3_uc011ceu.1_Missense_Mutation_p.M30I|UBE2D3_uc003hwo.2_Missense_Mutation_p.M30I|UBE2D3_uc003hwp.2_Missense_Mutation_p.M30I|UBE2D3_uc003hwq.2_Missense_Mutation_p.M32I|UBE2D3_uc003hwr.2_Missense_Mutation_p.M30I	NM_181887	NP_871616	P61077	UB2D3_HUMAN	ubiquitin-conjugating enzyme E2D 3 isoform 1	30					apoptosis|BMP signaling pathway|DNA repair|negative regulation of type I interferon production|proteasomal ubiquitin-dependent protein catabolic process|protein K11-linked ubiquitination|protein K48-linked ubiquitination|protein monoubiquitination|transforming growth factor beta receptor signaling pathway	endosome membrane|plasma membrane	ATP binding|protein binding|ubiquitin-protein ligase activity				0		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;2.13e-08)		GCCAATGAAACACTAGAAAAA	0.284		NaN											1	0	0.000157383	0.038147	0.000160124	7	40									
ANK2	287	broad.mit.edu	37	4	114251565	114251565	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr4:114251565G>A	uc003ibe.3	+	27	3164	c.3064G>A	c.(3064-3066)GAA>AAA	p.E1022K	ANK2_uc003ibd.3_Missense_Mutation_p.E1013K|ANK2_uc003ibf.3_Missense_Mutation_p.E1022K|ANK2_uc011cgc.1_Missense_Mutation_p.E231K|ANK2_uc003ibg.3_Missense_Mutation_p.E50K|ANK2_uc003ibc.2_Missense_Mutation_p.E998K|ANK2_uc011cgb.1_Missense_Mutation_p.E1037K	NM_001148	NP_001139	Q01484	ANK2_HUMAN	ankyrin 2 isoform 1	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding|protein binding			central_nervous_system(7)|ovary(3)|large_intestine(2)|breast(1)|skin(1)	14		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		TCCAATGGTGGAAGGAGAAGG	0.537		NaN											0	0	0	0.09836	0	39	17									
EDNRA	1909	broad.mit.edu	37	4	148406959	148406959	+	Silent	SNP	C	C	A			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr4:148406959C>A	uc003iky.2	+	2	818	c.126C>A	c.(124-126)GGC>GGA	p.G42G	EDNRA_uc011cid.1_Intron|EDNRA_uc010ipe.1_Silent_p.G42G|EDNRA_uc010ipf.1_RNA|EDNRA_uc010ipg.1_Silent_p.G42G	NM_001957	NP_001948	P25101	EDNRA_HUMAN	endothelin receptor type A isoform a precursor	42	Extracellular (Potential).				activation of adenylate cyclase activity|artery smooth muscle contraction|cell proliferation|glucose transport|respiratory gaseous exchange	integral to plasma membrane	endothelin-A receptor activity|phosphatidylinositol phospholipase C activity			ovary(1)|breast(1)	2	all_hematologic(180;0.151)			GBM - Glioblastoma multiforme(119;0.154)	Bosentan(DB00559)	CTTTTCGTGGCACAGAGCTCA	0.448		NaN											1	0	4.54149e-19	0.069288	4.90097e-19	24	123									
KIAA0922	23240	broad.mit.edu	37	4	154544213	154544213	+	Silent	SNP	C	C	T	rs140734056	byFrequency	TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr4:154544213C>T	uc003inm.3	+	29	4072	c.4020C>T	c.(4018-4020)GAC>GAT	p.D1340D	KIAA0922_uc010ipp.2_Silent_p.D1341D|KIAA0922_uc010ipq.2_Silent_p.D1109D	NM_015196	NP_056011	A2VDJ0	T131L_HUMAN	hypothetical protein LOC23240 isoform 2	1340	Cytoplasmic (Potential).					integral to membrane				upper_aerodigestive_tract(1)|ovary(1)	2	all_hematologic(180;0.093)	Renal(120;0.118)				CCATGGTGGACGCCCAGCACT	0.682		NaN											0	0	0	0.047766	0	8	57									
EXOC3	11336	broad.mit.edu	37	5	464494	464494	+	Silent	SNP	C	C	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr5:464494C>T	uc003jba.2	+	10	1871	c.1743C>T	c.(1741-1743)AAC>AAT	p.N581N		NM_007277	NP_009208	O60645	EXOC3_HUMAN	Sec6 protein	592					exocytosis|protein transport						0		Ovarian(839;0.0563)	Epithelial(17;0.000529)|OV - Ovarian serous cystadenocarcinoma(19;0.00153)|all cancers(22;0.00186)|Lung(60;0.0863)			ACTATTTCAACGATTTTGCCA	0.443		NaN											0	0	0	0.049695	0	19	209									
NDUFS6	4726	broad.mit.edu	37	5	1801637	1801637	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr5:1801637G>A	uc003jcy.2	+	1	129	c.106G>A	c.(106-108)GGG>AGG	p.G36R	MRPL36_uc003jcx.3_5'Flank	NM_004553	NP_004544	O75380	NDUS6_HUMAN	NADH dehydrogenase (ubiquinone) Fe-S protein 6,	36					mitochondrial electron transport, NADH to ubiquinone|transport	mitochondrial respiratory chain complex I	electron carrier activity|NADH dehydrogenase (ubiquinone) activity			central_nervous_system(1)	1					NADH(DB00157)	CTCGCCGACCGGGGAGAAGGT	0.721		NaN											0	0	0	0.069234	0	11	9									
ADCY2	108	broad.mit.edu	37	5	7520895	7520895	+	Silent	SNP	G	G	A			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr5:7520895G>A	uc003jdz.1	+	3	520	c.453G>A	c.(451-453)CTG>CTA	p.L151L		NM_020546	NP_065433	Q08462	ADCY2_HUMAN	adenylate cyclase 2	151	Helical; (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	cytoplasm|dendrite|integral to membrane|plasma membrane	ATP binding|metal ion binding			ovary(5)|pancreas(1)|skin(1)	7						ACACCATGCTGCCCTTCAACA	0.522		NaN											0	0	0	0.045705	0	32	150									
CDH10	1008	broad.mit.edu	37	5	24509787	24509787	+	Missense_Mutation	SNP	G	G	C			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr5:24509787G>C	uc003jgr.1	-	7	1476	c.1144C>G	c.(1144-1146)CCT>GCT	p.P382A	CDH10_uc011cnu.1_RNA	NM_006727	NP_006718	Q9Y6N8	CAD10_HUMAN	cadherin 10, type 2 preproprotein	382	Cadherin 3.|Extracellular (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(6)|pancreas(4)|breast(2)	12				STAD - Stomach adenocarcinoma(35;0.0556)		CTAAAAACAGGAGGTTCATCC	0.393		NaN								HNSCC(23;0.051)			0	0	0	0.0333	0	17	124									
ADAMTS12	81792	broad.mit.edu	37	5	33614470	33614470	+	Missense_Mutation	SNP	C	C	G			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr5:33614470C>G	uc003jia.1	-	16	2563	c.2400G>C	c.(2398-2400)CAG>CAC	p.Q800H	ADAMTS12_uc010iuq.1_Missense_Mutation_p.Q715H	NM_030955	NP_112217	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1	800	Spacer 1.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|kidney(1)	9						GGTTAGTCACCTGGAATAGAA	0.438		NaN								HNSCC(64;0.19)			0	0	0	0.038147	0	6	90									
CAPSL	133690	broad.mit.edu	37	5	35910153	35910153	+	Missense_Mutation	SNP	C	C	G			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr5:35910153C>G	uc003jjt.1	-	4	435	c.340G>C	c.(340-342)GAG>CAG	p.E114Q	CAPSL_uc003jju.1_Missense_Mutation_p.E114Q	NM_001042625	NP_001036090	Q8WWF8	CAPSL_HUMAN	calcyphosine-like	114	EF-hand 3.					cytoplasm	calcium ion binding			skin(1)	1	all_lung(31;0.000268)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Epithelial(62;0.167)|Colorectal(62;0.202)			ATGATTACCTCTTTTCTGGCT	0.353		NaN											0	0	0	0.139131	0	55	144									
EGFLAM	133584	broad.mit.edu	37	5	38435313	38435313	+	Missense_Mutation	SNP	G	G	C			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr5:38435313G>C	uc003jlc.1	+	16	2565	c.2241G>C	c.(2239-2241)AAG>AAC	p.K747N	EGFLAM_uc003jlb.1_Missense_Mutation_p.K747N|EGFLAM_uc003jle.1_Missense_Mutation_p.K513N|EGFLAM_uc003jlf.1_Missense_Mutation_p.K113N	NM_152403	NP_689616	Q63HQ2	EGFLA_HUMAN	EGF-like, fibronectin type III and laminin G	747	Laminin G-like 2.					cell junction|proteinaceous extracellular matrix|synapse				pancreas(3)|skin(3)|ovary(1)	7	all_lung(31;0.000385)					ATGTGAAGAAGAACTCGGGTG	0.463		NaN											0	0	0	0.125774	0	30	113									
ZNF131	7690	broad.mit.edu	37	5	43122240	43122240	+	Missense_Mutation	SNP	G	G	C			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr5:43122240G>C	uc011cpw.1	+	2	121	c.85G>C	c.(85-87)GAG>CAG	p.E29Q	ZNF131_uc010ivl.1_Missense_Mutation_p.E29Q|ZNF131_uc003jnj.3_5'UTR|ZNF131_uc003jnk.2_Missense_Mutation_p.E29Q|ZNF131_uc003jnn.3_5'UTR|ZNF131_uc003jnl.1_RNA|ZNF131_uc010ivm.1_RNA|ZNF131_uc003jnm.2_Missense_Mutation_p.E29Q	NM_003432	NP_003423	P52739	ZN131_HUMAN	zinc finger protein 131	29						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0						TGAACAGCGAGAGCAGGACCG	0.517		NaN											0	0	0	0.139131	0	89	88									
POLK	51426	broad.mit.edu	37	5	74877153	74877153	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr5:74877153G>A	uc003kdw.2	+	7	910	c.814G>A	c.(814-816)GAA>AAA	p.E272K	POLK_uc003kdx.2_RNA|POLK_uc003kdy.2_RNA|POLK_uc003kea.2_Missense_Mutation_p.E272K|POLK_uc003keb.2_Missense_Mutation_p.E272K|POLK_uc010izq.2_Missense_Mutation_p.E272K|POLK_uc003kec.2_Missense_Mutation_p.E182K|POLK_uc010izr.2_RNA|POLK_uc010izs.2_RNA|POLK_uc003ked.2_Missense_Mutation_p.E182K|POLK_uc003kee.2_Missense_Mutation_p.E272K|POLK_uc003kef.2_Missense_Mutation_p.E182K	NM_016218	NP_057302	Q9UBT6	POLK_HUMAN	DNA-directed DNA polymerase kappa	272	UmuC.				DNA replication|nucleotide-excision repair, DNA gap filling	nucleus	damaged DNA binding|DNA-directed DNA polymerase activity|metal ion binding			ovary(2)|kidney(2)	4		all_lung(232;0.0131)|Lung NSC(167;0.0282)|Ovarian(174;0.0798)|Prostate(461;0.184)		OV - Ovarian serous cystadenocarcinoma(47;2.9e-54)|all cancers(79;1.27e-42)		AGTGAACTTTGAAGAACAAAA	0.408		NaN						DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					0	0	0	0.076483	0	24	38									
POLK	51426	broad.mit.edu	37	5	74892196	74892196	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr5:74892196G>A	uc003kdw.2	+	13	1774	c.1678G>A	c.(1678-1680)GAA>AAA	p.E560K	POLK_uc003kdx.2_RNA|POLK_uc003kdy.2_RNA|POLK_uc010izq.2_Missense_Mutation_p.E362K|POLK_uc003kec.2_Missense_Mutation_p.E470K|POLK_uc010izr.2_RNA|POLK_uc010izs.2_RNA|POLK_uc003ked.2_Intron|POLK_uc003kee.2_Intron|POLK_uc003kef.2_Missense_Mutation_p.E470K	NM_016218	NP_057302	Q9UBT6	POLK_HUMAN	DNA-directed DNA polymerase kappa	560					DNA replication|nucleotide-excision repair, DNA gap filling	nucleus	damaged DNA binding|DNA-directed DNA polymerase activity|metal ion binding			ovary(2)|kidney(2)	4		all_lung(232;0.0131)|Lung NSC(167;0.0282)|Ovarian(174;0.0798)|Prostate(461;0.184)		OV - Ovarian serous cystadenocarcinoma(47;2.9e-54)|all cancers(79;1.27e-42)		AAAACCTCTAGAAATGTCTCA	0.358		NaN						DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					0	0	0	0.083992	0	24	23									
POC5	134359	broad.mit.edu	37	5	74970365	74970365	+	Silent	SNP	C	C	A			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr5:74970365C>A	uc003keh.3	-	12	1820	c.1623G>T	c.(1621-1623)CGG>CGT	p.R541R	POC5_uc010izu.2_Silent_p.R365R|POC5_uc003keg.3_Silent_p.R516R	NM_001099271	NP_001092741	Q8NA72	POC5_HUMAN	proteome of centriole 5 isoform 1	541					cell cycle	centriole				lung(1)	1						GATGAATGGTCCGGGGATATT	0.398		NaN											1	0	8.92586e-32	0.139131	9.8667e-32	92	79									
ACOT12	134526	broad.mit.edu	37	5	80640791	80640791	+	Silent	SNP	G	G	A			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr5:80640791G>A	uc003khl.3	-	8	898	c.843C>T	c.(841-843)ATC>ATT	p.I281I	RNU5E_uc011cto.1_Intron	NM_130767	NP_570123	Q8WYK0	ACO12_HUMAN	acyl-CoA thioesterase 12	281	Acyl coenzyme A hydrolase 2.				acyl-CoA metabolic process|fatty acid metabolic process	cytosol	acetyl-CoA hydrolase activity|carboxylesterase activity			ovary(1)|kidney(1)	2		Lung NSC(167;0.0176)|all_lung(232;0.0205)|Ovarian(174;0.135)		OV - Ovarian serous cystadenocarcinoma(54;1.37e-45)|Epithelial(54;1.25e-39)|all cancers(79;5.01e-34)		AAGCACTGTTGATGTGACGCC	0.493		NaN											0	0	0	0.104719	0	44	46									
UBE2B	7320	broad.mit.edu	37	5	133724024	133724024	+	Missense_Mutation	SNP	G	G	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr5:133724024G>T	uc003kzh.2	+	5	667	c.250G>T	c.(250-252)GAT>TAT	p.D84Y		NM_003337	NP_003328	P63146	UBE2B_HUMAN	ubiquitin-conjugating enzyme E2B	84					canonical Wnt receptor signaling pathway|histone H2A ubiquitination|negative regulation of cAMP-mediated signaling|postreplication repair|proteasomal ubiquitin-dependent protein catabolic process|protein autoubiquitination|protein K11-linked ubiquitination|protein K48-linked ubiquitination|protein K63-linked ubiquitination|protein monoubiquitination|protein stabilization|response to drug|response to UV	cytoplasm|plasma membrane|replication fork	ATP binding|ubiquitin protein ligase binding|ubiquitin-protein ligase activity			lung(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			AGTGTATGCTGATGGTAGCAT	0.348		NaN						Direct_reversal_of_damage|Rad6_pathway					1	0	4.96729e-08	0.049695	5.18271e-08	20	44									
PCDHAC2	56134	broad.mit.edu	37	5	140348520	140348520	+	Silent	SNP	C	C	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr5:140348520C>T	uc003lii.2	+	1	2409	c.2169C>T	c.(2167-2169)ATC>ATT	p.I723I	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc003lia.2_Intron|PCDHA12_uc003lic.2_Intron|PCDHA13_uc003lie.1_Intron|PCDHA13_uc003lif.2_Intron|PCDHAC1_uc003lih.2_Intron|PCDHAC2_uc011dag.1_Silent_p.I723I	NM_018899	NP_061722	Q9Y5I4	PCDC2_HUMAN	protocadherin alpha subfamily C, 2 isoform 1	723	Helical; (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			ovary(2)|skin(2)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TTTTGACAATCATCATTTTGA	0.433		NaN											0	0	0	0.11911	0	14	85									
PCDHAC2	56134	broad.mit.edu	37	5	140348753	140348753	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr5:140348753C>T	uc003lii.2	+	1	2642	c.2402C>T	c.(2401-2403)TCA>TTA	p.S801L	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc003lia.2_Intron|PCDHA12_uc003lic.2_Intron|PCDHA13_uc003lie.1_Intron|PCDHA13_uc003lif.2_Intron|PCDHAC1_uc003lih.2_Intron|PCDHAC2_uc011dag.1_Missense_Mutation_p.S801L	NM_018899	NP_061722	Q9Y5I4	PCDC2_HUMAN	protocadherin alpha subfamily C, 2 isoform 1	801	Cytoplasmic (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			ovary(2)|skin(2)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ACAGCAGGCTCAGGGAGTGAC	0.552		NaN											0	0	0	0.116897	0	28	54									
RBM22	55696	broad.mit.edu	37	5	150080509	150080509	+	Missense_Mutation	SNP	C	C	G			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr5:150080509C>G	uc003lst.2	-	1	161	c.39G>C	c.(37-39)CAG>CAC	p.Q13H		NM_018047	NP_060517	Q9NW64	RBM22_HUMAN	RNA binding motif protein 22	13					protein import into nucleus, translocation	catalytic step 2 spliceosome|cytoplasm	calcium-dependent protein binding|nucleotide binding|RNA binding|zinc ion binding				0		Medulloblastoma(196;0.167)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			CCTCCCAGTTCTGCCTGTTGT	0.637		NaN									OREG0016939	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.064281	0	33	31									
MSX2	4488	broad.mit.edu	37	5	174156555	174156555	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr5:174156555C>T	uc003mcy.2	+	2	861	c.773C>T	c.(772-774)CCA>CTA	p.P258L		NM_002449	NP_002440	P35548	MSX2_HUMAN	msh homeobox 2	258					cranial suture morphogenesis|negative regulation of transcription, DNA-dependent|osteoblast differentiation	cytoplasm|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding				0	Renal(175;0.000159)|Lung NSC(126;0.0196)|all_lung(126;0.0303)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)|all_hematologic(541;0.214)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000183)			TATGCCACGCCAGTGGGATAT	0.547		NaN											0	0	0	0.108266	0	27	58									
SLC35B3	51000	broad.mit.edu	37	6	8417151	8417151	+	Missense_Mutation	SNP	C	C	G	rs145512512		TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr6:8417151C>G	uc010joe.2	-	9	1117	c.951G>C	c.(949-951)TTG>TTC	p.L317F	SLC35B3_uc003mya.2_Missense_Mutation_p.L285F|SLC35B3_uc003myc.2_RNA|SLC35B3_uc003myb.2_Missense_Mutation_p.L317F|SLC35B3_uc011did.1_Missense_Mutation_p.L317F|SLC35B3_uc003myd.2_RNA	NM_001142541	NP_001136013	Q9H1N7	S35B3_HUMAN	solute carrier family 35, member B3	317	Helical; (Potential).				transmembrane transport	Golgi membrane|integral to membrane					0	Ovarian(93;0.0569)					AAATTTTAATCAAAGCCAGAA	0.348		NaN											0	0	0	0.139131	0	45	65									
JARID2	3720	broad.mit.edu	37	6	15452374	15452374	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr6:15452374C>T	uc003nbj.2	+	4	705	c.461C>T	c.(460-462)ACA>ATA	p.T154I	JARID2_uc011diu.1_Intron|JARID2_uc011div.1_5'UTR|JARID2_uc011diw.1_Missense_Mutation_p.T116I	NM_004973	NP_004964	Q92833	JARD2_HUMAN	jumonji, AT rich interactive domain 2 protein	154					central nervous system development|chromatin modification|negative regulation of histone methylation|positive regulation of histone H3-K9 methylation|stem cell differentiation|transcription, DNA-dependent		chromatin binding			ovary(2)|lung(1)|pancreas(1)	4	Breast(50;0.0142)|Ovarian(93;0.103)	all_hematologic(90;0.00612)				AAGCCTAAGACAGAAGATTTT	0.488		NaN											0	0	0	0.144211	0	31	74									
SLC17A2	10246	broad.mit.edu	37	6	25918715	25918715	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr6:25918715C>T	uc011dkb.1	-	5	732	c.649G>A	c.(649-651)GGT>AGT	p.G217S	SLC17A2_uc011dkc.1_Missense_Mutation_p.G217S|SLC17A2_uc003nfl.2_Missense_Mutation_p.G217S			O00624	NPT3_HUMAN	SubName: Full=Solute carrier family 17 (Sodium phosphate), member 2, isoform CRA_b; SubName: Full=Putative uncharacterized protein SLC17A2;	217	Helical; (Potential).				phosphate metabolic process	integral to plasma membrane|membrane fraction	sodium:phosphate symporter activity			ovary(1)	1						AGTGACTCACCAAAGATGTAG	0.443		NaN											0	0	0	0.069234	0	11	59									
FLOT1	10211	broad.mit.edu	37	6	30698322	30698322	+	Silent	SNP	G	G	C			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr6:30698322G>C	uc003nrm.2	-	11	1136	c.972C>G	c.(970-972)GCC>GCG	p.A324A	FLOT1_uc011dmr.1_Silent_p.A276A	NM_005803	NP_005794	O75955	FLOT1_HUMAN	flotillin 1	324						centriolar satellite|endosome|integral to membrane|melanosome|membrane fraction					0						CTATGGCAAAGGCCTCAGCTT	0.567		NaN											0	0	0	0.0918	0	25	249									
VARS2	57176	broad.mit.edu	37	6	30884992	30884992	+	Silent	SNP	G	G	A	rs59234326	by1000genomes	TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr6:30884992G>A	uc003nsc.1	+	8	1496	c.864G>A	c.(862-864)TCG>TCA	p.S288S	VARS2_uc003nsd.2_Silent_p.S288S|VARS2_uc011dmx.1_Silent_p.S288S|VARS2_uc011dmy.1_Silent_p.S148S|VARS2_uc011dmz.1_Silent_p.S318S|VARS2_uc011dna.1_Silent_p.S288S|VARS2_uc011dnb.1_RNA|VARS2_uc011dnc.1_RNA|VARS2_uc011dnd.1_5'Flank|VARS2_uc010jsg.1_5'Flank	NM_020442	NP_065175	Q5ST30	SYVM_HUMAN	valyl-tRNA synthetase 2, mitochondrial	288					valyl-tRNA aminoacylation	mitochondrion	ATP binding|valine-tRNA ligase activity			ovary(3)|central_nervous_system(1)	4						CAGCCATCTCGGACATTGAGG	0.438		NaN											0	0	0	0.139131	0	105	119									
VARS2	57176	broad.mit.edu	37	6	30889068	30889068	+	Missense_Mutation	SNP	G	G	C			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr6:30889068G>C	uc003nsc.1	+	16	2250	c.1618G>C	c.(1618-1620)GAG>CAG	p.E540Q	VARS2_uc011dmx.1_Missense_Mutation_p.E540Q|VARS2_uc011dmy.1_Missense_Mutation_p.E400Q|VARS2_uc011dmz.1_Missense_Mutation_p.E570Q|VARS2_uc011dna.1_Missense_Mutation_p.E538Q|VARS2_uc011dnb.1_RNA|VARS2_uc011dnc.1_RNA|VARS2_uc011dnd.1_5'UTR|VARS2_uc010jsg.1_5'UTR|VARS2_uc010jsh.1_5'Flank	NM_020442	NP_065175	Q5ST30	SYVM_HUMAN	valyl-tRNA synthetase 2, mitochondrial	540					valyl-tRNA aminoacylation	mitochondrion	ATP binding|valine-tRNA ligase activity			ovary(3)|central_nervous_system(1)	4						CCTGGTTGTAGAGGACCATGC	0.612		NaN											0	0	0	0.0918	0	25	61									
ATP6V1G2	534	broad.mit.edu	37	6	31513918	31513918	+	Nonsense_Mutation	SNP	G	G	A			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr6:31513918G>A	uc003nua.2	-	2	442	c.151C>T	c.(151-153)CGA>TGA	p.R51*	BAT1_uc003ntv.2_5'UTR|ATP6V1G2_uc003ntz.2_Nonsense_Mutation_p.R10*|NFKBIL1_uc011dnr.1_5'Flank|NFKBIL1_uc011dns.1_5'Flank|NFKBIL1_uc011dnt.1_5'Flank|NFKBIL1_uc003nuc.2_5'Flank|NFKBIL1_uc003nub.2_5'Flank	NM_130463	NP_569730	O95670	VATG2_HUMAN	ATPase, H+ transporting, lysosomal, V1 subunit	51					cellular iron ion homeostasis|insulin receptor signaling pathway|proton transport|transferrin transport	cytosol|melanosome|vacuolar proton-transporting V-type ATPase complex	hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances|protein binding				0						TCGTGCTCTCGCTCTCTGCGG	0.582		NaN											0	0	0	0.139131	0	52	117									
BAT2	7916	broad.mit.edu	37	6	31601375	31601375	+	Silent	SNP	G	G	A			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr6:31601375G>A	uc003nvb.3	+	17	4788	c.4539G>A	c.(4537-4539)AGG>AGA	p.R1513R	BAT2_uc011dnv.1_Intron|BAT2_uc003nvc.3_Silent_p.R1513R	NM_080686	NP_542417	P48634	PRC2A_HUMAN	HLA-B associated transcript-2	1513	4 X 57 AA type A repeats.					cytoplasm|nucleus	protein binding				0						CCTCTCCTAGGCCCCCAACCC	0.612		NaN											0	0	0	0.09319	0	12	40									
TULP1	7287	broad.mit.edu	37	6	35471368	35471368	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr6:35471368C>T	uc003okv.3	-	13	1303	c.1291G>A	c.(1291-1293)GAG>AAG	p.E431K	TULP1_uc003okw.3_Missense_Mutation_p.E378K	NM_003322	NP_003313	O00294	TULP1_HUMAN	tubby like protein 1	431					dendrite development|eye photoreceptor cell development|phagocytosis|photoreceptor cell maintenance|positive regulation of phagocytosis	cell junction|cytoplasm|extracellular region|photoreceptor inner segment|photoreceptor outer segment|synapse	actin filament binding|phosphatidylinositol-4,5-bisphosphate binding			ovary(2)|central_nervous_system(1)	3						CTCTCGTTCTCCGCACTCATG	0.637		NaN											0	0	0	0.115264	0	2	5									
CYP39A1	51302	broad.mit.edu	37	6	46620303	46620303	+	Missense_Mutation	SNP	G	G	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr6:46620303G>T	uc003oyf.1	-	1	221	c.17C>A	c.(16-18)CCA>CAA	p.P6Q	CYP39A1_uc011dwa.1_Missense_Mutation_p.P6Q|CYP39A1_uc010jzd.1_5'UTR|SLC25A27_uc011dwb.1_5'Flank|SLC25A27_uc003oyg.2_5'Flank|SLC25A27_uc003oyh.2_5'Flank|SLC25A27_uc011dwc.1_5'Flank	NM_016593	NP_057677	Q9NYL5	CP39A_HUMAN	cytochrome P450, family 39, subfamily A,	6					bile acid biosynthetic process|bile acid catabolic process|digestion|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	24-hydroxycholesterol 7alpha-hydroxylase activity|electron carrier activity|heme binding|oxysterol 7-alpha-hydroxylase activity			ovary(1)	1						AATCACTGTTGGGGAAATTAG	0.483		NaN											1	0	5.42381e-49	0.139131	6.07763e-49	88	264									
RNGTT	8732	broad.mit.edu	37	6	89388140	89388140	+	Splice_Site	SNP	T	T	C			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr6:89388140T>C	uc003pmr.2	-	14	1660	c.1440_splice	c.e14-1	p.G480_splice	RNGTT_uc003pms.2_Splice_Site_p.G457_splice|RNGTT_uc011dzu.1_Splice_Site_p.G397_splice|RNGTT_uc003pmt.2_Intron	NM_003800	NP_003791	O60942	MCE1_HUMAN	RNA guanylyltransferase and 5'-phosphatase						interspecies interaction between organisms|mRNA capping|transcription from RNA polymerase II promoter|viral reproduction	nucleoplasm	GTP binding|mRNA guanylyltransferase activity|polynucleotide 5'-phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			upper_aerodigestive_tract(1)	1		all_cancers(76;4.07e-09)|Prostate(29;1.16e-10)|Acute lymphoblastic leukemia(125;1.49e-10)|all_hematologic(105;7.79e-07)|all_epithelial(107;6.86e-05)		BRCA - Breast invasive adenocarcinoma(108;0.151)		GGAAGTAACCTACAAAGAAAA	0.254		NaN											0	0	0	0.076483	0	22	31									
ASCC3	10973	broad.mit.edu	37	6	101214503	101214503	+	Missense_Mutation	SNP	T	T	C			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr6:101214503T>C	uc003pqk.2	-	10	2004	c.1675A>G	c.(1675-1677)ATC>GTC	p.I559V	ASCC3_uc011eai.1_Missense_Mutation_p.I461V|ASCC3_uc003pql.2_Missense_Mutation_p.I559V	NM_006828	NP_006819	Q8N3C0	HELC1_HUMAN	activating signal cointegrator 1 complex subunit	559	Helicase ATP-binding 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|microtubule cytoskeleton	ATP binding|ATP-dependent helicase activity|nucleic acid binding			ovary(5)|skin(1)	6		all_cancers(76;1.45e-07)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(87;0.00149)|Hepatocellular(1;0.0893)|Colorectal(196;0.13)		BRCA - Breast invasive adenocarcinoma(108;0.0539)|all cancers(137;0.103)|GBM - Glioblastoma multiforme(226;0.199)		TTCACAATGATGCCTAGTGGC	0.383		NaN											0	0	0	0.09836	0	42	74									
GRIK2	2898	broad.mit.edu	37	6	102483434	102483434	+	Silent	SNP	T	T	C			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr6:102483434T>C	uc003pqp.3	+	14	2553	c.2304T>C	c.(2302-2304)ACT>ACC	p.T768T	GRIK2_uc003pqo.3_Silent_p.T768T|GRIK2_uc010kcw.2_Silent_p.T768T	NM_021956	NP_068775	Q13002	GRIK2_HUMAN	glutamate receptor, ionotropic, kainate 2	768	Extracellular (Potential).				glutamate signaling pathway|induction of programmed cell death in response to chemical stimulus|neuron apoptosis|positive regulation of synaptic transmission|regulation of short-term neuronal synaptic plasticity	cell junction|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			ovary(2)|pancreas(1)|breast(1)|skin(1)	5		all_cancers(76;1.19e-07)|Acute lymphoblastic leukemia(125;6.17e-11)|all_hematologic(75;6.01e-08)|all_epithelial(87;0.0121)|Colorectal(196;0.14)		all cancers(137;0.112)|BRCA - Breast invasive adenocarcinoma(108;0.124)|GBM - Glioblastoma multiforme(226;0.206)	L-Glutamic Acid(DB00142)	GCGTTGGCACTCCCATGGGTA	0.443		NaN											0	0	0	0.131918	0	47	134									
PPIL4	85313	broad.mit.edu	37	6	149867087	149867087	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr6:149867087C>T	uc003qmo.1	-	1	85	c.55G>A	c.(55-57)GAA>AAA	p.E19K	PPIL4_uc010kic.2_RNA|PPIL4_uc003qmp.1_Missense_Mutation_p.E19K	NM_139126	NP_624311	Q8WUA2	PPIL4_HUMAN	peptidylprolyl isomerase-like 4	19	PPIase cyclophilin-type.				protein folding	nucleus	nucleotide binding|peptidyl-prolyl cis-trans isomerase activity|RNA binding				0		Ovarian(120;0.0164)		OV - Ovarian serous cystadenocarcinoma(155;1.11e-11)|GBM - Glioblastoma multiforme(68;0.0885)		GGCCGTTCTTCGGTGTACAAG	0.647		NaN											0	0	0	0.014758	0	5	9									
SYNE1	23345	broad.mit.edu	37	6	152686043	152686043	+	Nonsense_Mutation	SNP	G	G	A			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr6:152686043G>A	uc010kiw.2	-	63	10686	c.10084C>T	c.(10084-10086)CAG>TAG	p.Q3362*	SYNE1_uc003qot.3_Nonsense_Mutation_p.Q3369*|SYNE1_uc003qou.3_Nonsense_Mutation_p.Q3362*|SYNE1_uc010kja.1_Nonsense_Mutation_p.Q67*	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	3362	Spectrin 7.|HAT 6.|Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		CTCTGCAGCTGCTGCTGAATA	0.458		NaN								HNSCC(10;0.0054)			0	0	0	0.064281	0	37	93									
MAD1L1	8379	broad.mit.edu	37	7	2188842	2188842	+	Missense_Mutation	SNP	C	C	G			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr7:2188842C>G	uc003slh.1	-	11	1284	c.1018G>C	c.(1018-1020)GAG>CAG	p.E340Q	MAD1L1_uc003sle.1_Missense_Mutation_p.E69Q|MAD1L1_uc003slf.1_Missense_Mutation_p.E340Q|MAD1L1_uc003slg.1_Missense_Mutation_p.E340Q|MAD1L1_uc010ksh.1_Missense_Mutation_p.E340Q|MAD1L1_uc003sli.1_Missense_Mutation_p.E248Q|MAD1L1_uc010ksi.1_Missense_Mutation_p.E293Q|MAD1L1_uc010ksj.2_Missense_Mutation_p.E340Q	NM_001013836	NP_001013858	Q9Y6D9	MD1L1_HUMAN	MAD1-like 1 protein	340	Potential.				cell division|mitotic anaphase|mitotic cell cycle spindle assembly checkpoint|mitotic metaphase|mitotic prometaphase|mitotic telophase	actin cytoskeleton|centrosome|condensed chromosome kinetochore|cytosol|mitochondrion|nucleus|spindle	protein binding			lung(1)|central_nervous_system(1)	2		Ovarian(82;0.0272)		UCEC - Uterine corpus endometrioid carcinoma (27;0.134)|OV - Ovarian serous cystadenocarcinoma(56;3.63e-14)		TGCTGCAGCTCAACCACGAAT	0.547		NaN											0	0	0	0.09319	0	12	34									
ANLN	54443	broad.mit.edu	37	7	36438775	36438775	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr7:36438775C>T	uc003tff.2	+	3	464	c.260C>T	c.(259-261)CCA>CTA	p.P87L	ANLN_uc011kaz.1_Intron|ANLN_uc003tfg.2_Missense_Mutation_p.P87L|ANLN_uc010kxe.2_Missense_Mutation_p.P87L	NM_018685	NP_061155	Q9NQW6	ANLN_HUMAN	anillin, actin binding protein	87	Nuclear localization.|Interaction with CD2AP.				cytokinesis|mitosis|regulation of exit from mitosis|septin ring assembly	actomyosin contractile ring|nucleus	actin binding			ovary(2)|skin(1)	3						AATAAACAACCAGTTGAGTCG	0.418		NaN											0	0	0	0.105934	0	14	51									
POLD2	5425	broad.mit.edu	37	7	44156568	44156568	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr7:44156568C>T	uc010kxz.2	-	7	1278	c.628G>A	c.(628-630)GAG>AAG	p.E210K	POLD2_uc003tke.3_Missense_Mutation_p.E210K|POLD2_uc010kya.2_Missense_Mutation_p.E210K|POLD2_uc003tkf.3_Missense_Mutation_p.E210K	NM_006230	NP_006221	P49005	DPOD2_HUMAN	DNA-directed DNA polymerase delta 2	210					base-excision repair|DNA strand elongation involved in DNA replication|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	nucleoplasm	DNA binding|DNA-directed DNA polymerase activity|protein binding			ovary(2)	2						AGCAGGCTCTCGCCTCCACCG	0.692		NaN											0	0	0	0.09319	0	12	20									
TYW1	55253	broad.mit.edu	37	7	66463173	66463173	+	Missense_Mutation	SNP	C	C	G			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr7:66463173C>G	uc003tvn.2	+	2	275	c.126C>G	c.(124-126)ATC>ATG	p.I42M	SBDS_uc003tvm.1_5'Flank|TYW1_uc010lai.2_RNA	NM_018264	NP_060734	Q9NV66	TYW1_HUMAN	radical S-adenosyl methionine and flavodoxin	42					tRNA processing		4 iron, 4 sulfur cluster binding|FMN binding|iron ion binding|oxidoreductase activity			skin(1)	1		Lung NSC(55;0.0846)|all_lung(88;0.183)				AGATTGTCATCAAGACGCAGG	0.318		NaN											0	0	0	0.092188	0	39	118									
BAZ1B	9031	broad.mit.edu	37	7	72892759	72892759	+	Silent	SNP	C	C	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr7:72892759C>T	uc003tyc.2	-	7	1377	c.1032G>A	c.(1030-1032)AAG>AAA	p.K344K		NM_032408	NP_115784	Q9UIG0	BAZ1B_HUMAN	bromodomain adjacent to zinc finger domain, 1B	344	Mediates the tyrosine-protein kinase activity.|Lys-rich.				ATP-dependent chromatin remodeling|chromatin-mediated maintenance of transcription|DNA replication-dependent nucleosome disassembly|double-strand break repair|heart morphogenesis|transcription, DNA-dependent	WINAC complex	ATP binding|chromatin binding|histone acetyl-lysine binding|histone kinase activity|non-membrane spanning protein tyrosine kinase activity|protein complex scaffold|vitamin D receptor activator activity|vitamin D receptor binding|zinc ion binding			ovary(4)|upper_aerodigestive_tract(1)|breast(1)|skin(1)	7		Lung NSC(55;0.0659)|all_lung(88;0.152)				CACTCAATGACTTCTTCAAGT	0.423		NaN											0	0	0	0.059317	0	30	78									
SEMA3C	10512	broad.mit.edu	37	7	80418743	80418743	+	Missense_Mutation	SNP	G	G	C			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr7:80418743G>C	uc003uhj.2	-	12	1795	c.1233C>G	c.(1231-1233)ATC>ATG	p.I411M	SEMA3C_uc011kgw.1_Missense_Mutation_p.I429M	NM_006379	NP_006370	Q99985	SEM3C_HUMAN	semaphorin 3C precursor	411	Sema.				immune response|response to drug	membrane	receptor activity			ovary(1)	1						GGATTGGGTAGATGGAATTGT	0.453		NaN											0	0	0	0.139131	0	47	56									
BAIAP2L1	55971	broad.mit.edu	37	7	97944889	97944889	+	Silent	SNP	G	G	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr7:97944889G>T	uc003upj.2	-	7	785	c.522C>A	c.(520-522)ATC>ATA	p.I174I		NM_018842	NP_061330	Q9UHR4	BI2L1_HUMAN	BAI1-associated protein 2-like 1	174	IMD.				filopodium assembly|positive regulation of actin cytoskeleton reorganization|positive regulation of actin filament polymerization|response to bacterium|signal transduction	cell junction|cytoskeleton|cytosol|nucleus	actin binding|cytoskeletal adaptor activity|proline-rich region binding|SH3 domain binding			ovary(1)	1	all_cancers(62;4.34e-10)|all_epithelial(64;5e-10)|Esophageal squamous(72;0.00918)|Lung NSC(181;0.0113)|all_lung(186;0.0126)		STAD - Stomach adenocarcinoma(171;0.215)			TGAATTTCTGGATTTCACTCT	0.383		NaN											1	0	2.20262e-25	0.054565	2.40875e-25	35	119									
SMURF1	57154	broad.mit.edu	37	7	98645380	98645380	+	Missense_Mutation	SNP	C	C	A			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr7:98645380C>A	uc003upu.1	-	11	1477	c.1157G>T	c.(1156-1158)AGA>ATA	p.R386I	SMURF1_uc003upv.1_Missense_Mutation_p.R360I|SMURF1_uc003upt.2_Missense_Mutation_p.R360I	NM_020429	NP_065162	Q9HCE7	SMUF1_HUMAN	Smad ubiquitination regulatory factor 1 isoform	386					BMP signaling pathway|cell differentiation|ectoderm development|negative regulation of BMP signaling pathway|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of protein ubiquitination|proteasomal ubiquitin-dependent protein catabolic process|protein export from nucleus|protein localization at cell surface|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|receptor catabolic process|transforming growth factor beta receptor signaling pathway|ubiquitin-dependent SMAD protein catabolic process	cytosol|plasma membrane	activin binding|I-SMAD binding|R-SMAD binding|ubiquitin-protein ligase activity			skin(2)|ovary(1)|lung(1)	4	all_cancers(62;1.05e-08)|all_epithelial(64;4.34e-09)|Lung NSC(181;0.00902)|all_lung(186;0.0145)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)|Lung(104;0.224)			CAGTTCGTGTCTGAGGACTTT	0.562		NaN											1	0	1.77791e-30	0.139131	1.96002e-30	70	264									
SMURF1	57154	broad.mit.edu	37	7	98645441	98645441	+	Missense_Mutation	SNP	C	C	A			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr7:98645441C>A	uc003upu.1	-	11	1416	c.1096G>T	c.(1096-1098)GAC>TAC	p.D366Y	SMURF1_uc003upv.1_Missense_Mutation_p.D340Y|SMURF1_uc003upt.2_Missense_Mutation_p.D340Y	NM_020429	NP_065162	Q9HCE7	SMUF1_HUMAN	Smad ubiquitination regulatory factor 1 isoform	366					BMP signaling pathway|cell differentiation|ectoderm development|negative regulation of BMP signaling pathway|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of protein ubiquitination|proteasomal ubiquitin-dependent protein catabolic process|protein export from nucleus|protein localization at cell surface|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|receptor catabolic process|transforming growth factor beta receptor signaling pathway|ubiquitin-dependent SMAD protein catabolic process	cytosol|plasma membrane	activin binding|I-SMAD binding|R-SMAD binding|ubiquitin-protein ligase activity			skin(2)|ovary(1)|lung(1)	4	all_cancers(62;1.05e-08)|all_epithelial(64;4.34e-09)|Lung NSC(181;0.00902)|all_lung(186;0.0145)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)|Lung(104;0.224)			AGCTCCTCGTCCTCCAGAGAG	0.562		NaN											1	0	1.52378e-38	0.139131	1.69355e-38	69	290									
ZKSCAN1	7586	broad.mit.edu	37	7	99621898	99621898	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr7:99621898C>T	uc003usk.1	+	3	767	c.548C>T	c.(547-549)TCG>TTG	p.S183L	ZKSCAN1_uc003usj.2_Missense_Mutation_p.S182L|ZKSCAN1_uc003usl.1_Missense_Mutation_p.S147L|ZKSCAN1_uc003usm.1_Intron	NM_003439	NP_003430	P17029	ZKSC1_HUMAN	zinc finger protein 36	183					viral reproduction	mitochondrion|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(3)	3	Lung NSC(181;0.0211)|all_lung(186;0.0323)|Esophageal squamous(72;0.0439)		STAD - Stomach adenocarcinoma(171;0.129)			TTCAAACATTCGTCTCGGAAA	0.532		NaN											0	0	0	0.038395	0	17	57									
ACHE	43	broad.mit.edu	37	7	100491073	100491073	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr7:100491073C>T	uc003uxd.2	-	1	937	c.781G>A	c.(781-783)GGT>AGT	p.G261S	ACHE_uc003uxe.2_Missense_Mutation_p.G261S|ACHE_uc003uxf.2_Missense_Mutation_p.G261S|ACHE_uc003uxg.2_Missense_Mutation_p.G261S|ACHE_uc003uxh.2_Missense_Mutation_p.G261S|ACHE_uc003uxi.2_Missense_Mutation_p.G261S|ACHE_uc003uxj.1_Missense_Mutation_p.G380S	NM_000665	NP_000656	P22303	ACES_HUMAN	acetylcholinesterase isoform E4-E6 precursor	261					acetylcholine catabolic process in synaptic cleft|amyloid precursor protein metabolic process|cell adhesion|cell proliferation|choline metabolic process|DNA replication|muscle organ development|neurotransmitter biosynthetic process|osteoblast development|positive regulation of protein secretion|regulation of axonogenesis|regulation of dendrite morphogenesis|response to wounding|synapse assembly	anchored to membrane|axon|basal lamina|cell junction|cell surface|dendrite|endoplasmic reticulum lumen|extracellular space|Golgi apparatus|neuromuscular junction|nucleus|perinuclear region of cytoplasm|postsynaptic membrane|presynaptic membrane|synaptic cleft	acetylcholine binding|acetylcholinesterase activity|beta-amyloid binding|carboxylesterase activity|cholinesterase activity|collagen binding|laminin-1 binding|protein homodimerization activity|serine hydrolase activity			skin(2)	2	Lung NSC(181;0.041)|all_lung(186;0.0581)				Ambenonium(DB01122)|Atropine(DB00572)|Choline(DB00122)|Decamethonium(DB01245)|Demecarium bromide(DB00944)|Donepezil(DB00843)|Edrophonium(DB01010)|Ephedrine(DB01364)|Galantamine(DB00674)|Gallamine Triethiodide(DB00483)|Isoflurophate(DB00677)|Neostigmine(DB01400)|Physostigmine(DB00981)|Pyridostigmine(DB00545)|Rivastigmine(DB00989)|Tacrine(DB00382)|Tubocurarine(DB01199)	TTGGGGGCACCGCTCTGCAGC	0.726		NaN											0	0	0	0.105934	0	14	51									
GPR22	2845	broad.mit.edu	37	7	107114751	107114751	+	Missense_Mutation	SNP	G	G	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr7:107114751G>T	uc003vef.2	+	3	1592	c.246G>T	c.(244-246)ATG>ATT	p.M82I	COG5_uc003vec.2_Intron|COG5_uc003ved.2_Intron|COG5_uc003vee.2_Intron	NM_005295	NP_005286	Q99680	GPR22_HUMAN	G protein-coupled receptor 22	82	Cytoplasmic (Potential).					integral to plasma membrane	G-protein coupled receptor activity			ovary(2)	2						TTATTACAATGAATCTTCATG	0.363		NaN											1	0	5.22555e-25	0.139131	5.69934e-25	58	94									
ST7	7982	broad.mit.edu	37	7	116869839	116869839	+	Missense_Mutation	SNP	C	C	G			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr7:116869839C>G	uc011knn.1	+	14	1371	c.1366C>G	c.(1366-1368)CTT>GTT	p.L456V	ST7_uc003vio.2_Silent_p.P531P|ST7_uc003viq.2_Silent_p.P508P|ST7_uc011knm.1_Silent_p.P511P|ST7_uc003vir.2_Silent_p.P474P	NM_021908	NP_068708	Q9NRC1	ST7_HUMAN	suppression of tumorigenicity 7 isoform b	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment						integral to membrane	binding			central_nervous_system(1)|skin(1)	2	all_cancers(3;3.88e-07)|all_epithelial(6;3.42e-07)|Lung NSC(10;0.00072)|all_lung(10;0.000847)		STAD - Stomach adenocarcinoma(10;0.000512)	LUSC - Lung squamous cell carcinoma(290;0.133)		TGTTTGCCCCCTTAAACTTTG	0.498		NaN											0	0	0	0.139131	0	89	448									
IMPDH1	3614	broad.mit.edu	37	7	128038653	128038653	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr7:128038653C>T	uc011kol.1	-	7	740	c.634G>A	c.(634-636)GTC>ATC	p.V212I	IMPDH1_uc011kom.1_Missense_Mutation_p.V207I|IMPDH1_uc003vmt.2_Missense_Mutation_p.V187I|IMPDH1_uc003vmu.2_Missense_Mutation_p.V297I|IMPDH1_uc003vmw.2_Missense_Mutation_p.V287I|IMPDH1_uc011kon.1_Missense_Mutation_p.V264I|IMPDH1_uc003vmv.2_Missense_Mutation_p.V261I|IMPDH1_uc003vmx.2_Missense_Mutation_p.V220I|IMPDH1_uc003vmy.2_Missense_Mutation_p.V228I	NM_001142573	NP_001136045	P20839	IMDH1_HUMAN	inosine monophosphate dehydrogenase 1 isoform e	212	CBS 2.				GMP biosynthetic process|purine base metabolic process	cytosol|nucleus	DNA binding|IMP dehydrogenase activity|metal ion binding			skin(2)|lung(1)|central_nervous_system(1)	4					Mycophenolate mofetil(DB00688)|Mycophenolic acid(DB01024)|NADH(DB00157)|Ribavirin(DB00811)|Thioguanine(DB00352)	CAATCATTGACGATAGGCAGC	0.542		NaN									OREG0018292	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.069234	0	11	158									
TMEM139	135932	broad.mit.edu	37	7	142983872	142983872	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr7:142983872C>T	uc010lov.2	+	4	740	c.601C>T	c.(601-603)CAC>TAC	p.H201Y	CASP2_uc003wco.2_5'Flank|CASP2_uc003wcp.2_5'Flank|CASP2_uc011kta.1_5'Flank|CASP2_uc003wcq.2_5'Flank|TMEM139_uc003wck.3_Missense_Mutation_p.H201Y|TMEM139_uc003wcl.2_Missense_Mutation_p.H201Y|TMEM139_uc003wcm.2_Missense_Mutation_p.H201Y|TMEM139_uc003wcn.2_RNA	NM_153345	NP_699176	Q8IV31	TM139_HUMAN	transmembrane protein 139 precursor	201	Cytoplasmic (Potential).					integral to membrane					0	Melanoma(164;0.059)					CTGCTTTGGTCACCCTGATGA	0.502		NaN											0	0	0	0.139131	0	70	67									
FAM115A	9747	broad.mit.edu	37	7	143573631	143573631	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr7:143573631G>A	uc003wdo.1	-	2	204	c.71C>T	c.(70-72)GCT>GTT	p.A24V	FAM115A_uc011ktu.1_Intron|FAM115A_uc003wdp.1_Missense_Mutation_p.A24V	NM_014719	NP_055534	Q9Y4C2	F115A_HUMAN	hypothetical protein LOC9747	24											0	Melanoma(164;0.0903)					ACATGGAACAGCATCTTCGGG	0.527		NaN											0	0	0	0.009096	0	4	60									
BLK	640	broad.mit.edu	37	8	11405588	11405588	+	Silent	SNP	C	C	A	rs149393791	byFrequency	TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr8:11405588C>A	uc003wty.2	+	4	804	c.223C>A	c.(223-225)CGG>AGG	p.R75R	BLK_uc003wtz.2_Silent_p.R4R	NM_001715	NP_001706	P51451	BLK_HUMAN	B lymphoid tyrosine kinase	75	SH3.				intracellular protein kinase cascade|positive regulation of insulin secretion		ATP binding|non-membrane spanning protein tyrosine kinase activity			large_intestine(1)|stomach(1)|ovary(1)	3			STAD - Stomach adenocarcinoma(15;0.00391)	COAD - Colon adenocarcinoma(149;0.207)		TATGAATGATCGGGACCTGCA	0.567		NaN											1	0	5.26018e-13	0.062417	5.63197e-13	21	33									
WRN	7486	broad.mit.edu	37	8	30933803	30933803	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr8:30933803G>A	uc003xio.3	+	8	1627	c.839G>A	c.(838-840)AGG>AAG	p.R280K		NM_000553	NP_000544	Q14191	WRN_HUMAN	Werner syndrome protein	280					base-excision repair|cellular response to starvation|DNA recombination|DNA synthesis involved in DNA repair|multicellular organismal aging|nucleolus to nucleoplasm transport|positive regulation of hydrolase activity|regulation of apoptosis|replication fork processing|response to oxidative stress|response to UV-C|telomere maintenance	centrosome|nucleolus|nucleoplasm	3'-5' exonuclease activity|ATP binding|ATP-dependent 3'-5' DNA helicase activity|bubble DNA binding|four-way junction helicase activity|G-quadruplex DNA binding|magnesium ion binding|manganese ion binding|protein complex binding|protein homodimerization activity|Y-form DNA binding			ovary(2)|kidney(2)|large_intestine(1)|lung(1)|skin(1)	7		Breast(100;0.195)		KIRC - Kidney renal clear cell carcinoma(542;0.147)|Kidney(114;0.176)|Colorectal(111;0.192)		AACCCACGGAGGTTAAATATT	0.328		NaN	Mis|N|F|S			osteosarcoma|meningioma|others		Genes_defective_in_diseases_associated_with_sensitivity_to_DNA_damaging_agents	Werner_syndrome				0	0	0	0.099896	0	28	30									
KCNU1	157855	broad.mit.edu	37	8	36644853	36644853	+	Silent	SNP	G	G	A			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr8:36644853G>A	uc010lvw.2	+	2	312	c.225G>A	c.(223-225)AGG>AGA	p.R75R	KCNU1_uc003xjw.2_RNA	NM_001031836	NP_001027006	A8MYU2	KCNU1_HUMAN	potassium channel, subfamily U, member 1	75	Cytoplasmic (Potential).					voltage-gated potassium channel complex	binding|large conductance calcium-activated potassium channel activity|voltage-gated potassium channel activity			ovary(1)	1				KIRC - Kidney renal clear cell carcinoma(67;0.0504)|Kidney(114;0.0634)		CCATCGCTAGGAGCCATGTAA	0.428		NaN											0	0	0	0.038147	0	8	17									
TACC1	6867	broad.mit.edu	37	8	38677879	38677879	+	Nonsense_Mutation	SNP	C	C	T	rs149014810	by1000genomes	TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr8:38677879C>T	uc010lwp.2	+	3	1496	c.1117C>T	c.(1117-1119)CGA>TGA	p.R373*	TACC1_uc011lby.1_Nonsense_Mutation_p.R178*|TACC1_uc003xma.2_Intron|TACC1_uc003xlz.2_Nonsense_Mutation_p.R178*|TACC1_uc003xmc.3_Nonsense_Mutation_p.R178*|TACC1_uc011lbz.1_Nonsense_Mutation_p.R389*|TACC1_uc003xmb.3_Nonsense_Mutation_p.R328*|TACC1_uc003xme.1_Intron|TACC1_uc003xmd.1_Intron|TACC1_uc010lwo.1_Intron|TACC1_uc003xmf.3_Intron|TACC1_uc011lca.1_Nonsense_Mutation_p.R373*|TACC1_uc011lcb.1_Nonsense_Mutation_p.R178*|TACC1_uc011lcc.1_Nonsense_Mutation_p.R178*|TACC1_uc011lcd.1_RNA|TACC1_uc003xmh.3_Nonsense_Mutation_p.R178*|TACC1_uc010lwq.2_Nonsense_Mutation_p.R178*	NM_006283	NP_006274	O75410	TACC1_HUMAN	transforming, acidic coiled-coil containing	373	Interaction with YEATS4.|SPAZ 2.				cell cycle|cell division	intermediate filament cytoskeleton|microtubule organizing center|nucleus	protein binding			ovary(1)	1		all_lung(54;0.00292)|Lung NSC(58;0.0115)|Hepatocellular(245;0.065)	LUSC - Lung squamous cell carcinoma(45;1.7e-09)|COAD - Colon adenocarcinoma(9;0.235)			CCCAGTGGCACGAGACGGGCC	0.527		NaN											0	0	0	0.050027	0	32	205									
PRKDC	5591	broad.mit.edu	37	8	48740729	48740729	+	Silent	SNP	C	C	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr8:48740729C>T	uc003xqi.2	-	63	8634	c.8577G>A	c.(8575-8577)CAG>CAA	p.Q2859Q	PRKDC_uc003xqj.2_Silent_p.Q2859Q|PRKDC_uc011ldh.1_Intron	NM_006904	NP_008835	P78527	PRKDC_HUMAN	protein kinase, DNA-activated, catalytic	2859	KIP-binding.				cellular response to insulin stimulus|double-strand break repair via nonhomologous end joining|peptidyl-serine phosphorylation|positive regulation of transcription from RNA polymerase II promoter	DNA-dependent protein kinase-DNA ligase 4 complex|transcription factor complex	ATP binding|DNA binding|DNA-dependent protein kinase activity|transcription factor binding			lung(12)|central_nervous_system(9)|ovary(6)|skin(4)|large_intestine(3)	34		all_cancers(86;0.0336)|all_epithelial(80;0.00111)|Lung NSC(129;0.00363)|all_lung(136;0.00391)				CAGACTTTACCTGAATACAAG	0.383		NaN						NHEJ					0	0	0	0.132662	0	16	11									
EFCAB1	79645	broad.mit.edu	37	8	49637345	49637345	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr8:49637345C>T	uc003xqo.2	-	6	752	c.592G>A	c.(592-594)GAA>AAA	p.E198K	EFCAB1_uc003xqn.3_Intron|EFCAB1_uc011ldj.1_Missense_Mutation_p.E146K|EFCAB1_uc010lxx.2_RNA|EFCAB1_uc011ldk.1_RNA	NM_024593	NP_078869	Q9HAE3	EFCB1_HUMAN	EF-hand calcium binding domain 1 isoform a	198							calcium ion binding				0		all_epithelial(80;0.0134)|Lung NSC(129;0.0207)|all_lung(136;0.0464)				ACTTGAGCTTCAAATTCCATC	0.313		NaN											0	0	0	0.083992	0	24	14									
NSMAF	8439	broad.mit.edu	37	8	59506850	59506850	+	Splice_Site	SNP	C	C	G			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr8:59506850C>G	uc003xtt.2	-	23	2107	c.1893_splice	c.e23-1	p.E631_splice	NSMAF_uc011lee.1_Splice_Site_p.E662_splice	NM_003580	NP_003571	Q92636	FAN_HUMAN	neutral sphingomyelinase (N-SMase) activation						ceramide metabolic process	cytoplasm|soluble fraction	protein binding|receptor signaling protein activity			ovary(1)	1		all_lung(136;0.174)|Lung NSC(129;0.2)				AGTAACTGCTCTGCTCAAAAA	0.388		NaN											0	0	0	0.009096	0	4	43									
C8orf34	116328	broad.mit.edu	37	8	69358639	69358639	+	Nonsense_Mutation	SNP	C	C	G			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr8:69358639C>G	uc010lyz.2	+	3	342	c.293C>G	c.(292-294)TCA>TGA	p.S98*	C8orf34_uc010lyx.1_Nonsense_Mutation_p.S98*|C8orf34_uc010lyy.1_Nonsense_Mutation_p.S98*|C8orf34_uc003xyb.2_Nonsense_Mutation_p.S73*	NM_052958	NP_443190	Q49A92	CH034_HUMAN	hypothetical protein LOC116328	98					signal transduction		cAMP-dependent protein kinase regulator activity			large_intestine(1)	1			Epithelial(68;0.0117)|OV - Ovarian serous cystadenocarcinoma(28;0.0227)|all cancers(69;0.0502)			CCTAAAAAATCAAAAAGTGAC	0.328		NaN											0	0	0	0.02938	0	6	77									
ZFHX4	79776	broad.mit.edu	37	8	77764196	77764196	+	Missense_Mutation	SNP	C	C	G			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr8:77764196C>G	uc003yav.2	+	10	5291	c.4904C>G	c.(4903-4905)TCT>TGT	p.S1635C	ZFHX4_uc003yau.1_Missense_Mutation_p.S1680C|ZFHX4_uc003yaw.1_Missense_Mutation_p.S1635C	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	1635						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			GATTTAATCTCTGCTCAACCT	0.418		NaN								HNSCC(33;0.089)			0	0	0	0.139131	0	54	31									
FBXO43	286151	broad.mit.edu	37	8	101154324	101154324	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr8:101154324G>A	uc003yjd.2	-	2	871	c.158C>T	c.(157-159)TCT>TTT	p.S53F	FBXO43_uc003yje.2_Missense_Mutation_p.S19F|FBXO43_uc010mbp.1_Missense_Mutation_p.S53F	NM_001029860	NP_001025031	Q4G163	FBX43_HUMAN	F-box protein 43 isoform b	53					meiosis		zinc ion binding			kidney(1)|skin(1)	2	all_cancers(14;0.000139)|all_epithelial(15;2.84e-07)|Lung NSC(17;0.000274)|all_lung(17;0.000798)		Epithelial(11;1.17e-09)|all cancers(13;1.34e-07)|OV - Ovarian serous cystadenocarcinoma(57;3.82e-05)|STAD - Stomach adenocarcinoma(118;0.0957)			AATTGGAGGAGAGTCCGCCCC	0.423		NaN											0	0	0	0.139131	0	95	39									
TAF2	6873	broad.mit.edu	37	8	120770342	120770342	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr8:120770342C>T	uc003you.2	-	21	3009	c.2739G>A	c.(2737-2739)ATG>ATA	p.M913I		NM_003184	NP_003175	Q6P1X5	TAF2_HUMAN	TBP-associated factor 2	913					G2/M transition of mitotic cell cycle|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	transcription factor TFIID complex|transcription factor TFTC complex	metallopeptidase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			large_intestine(2)|ovary(2)|kidney(1)|skin(1)	6	Lung NSC(37;9.35e-07)|Ovarian(258;0.011)|Hepatocellular(40;0.161)		STAD - Stomach adenocarcinoma(47;0.00185)			CATTCTGAATCATATTAAGTA	0.284		NaN											0	0	0	0.043863	0	17	155									
ATAD2	29028	broad.mit.edu	37	8	124371897	124371897	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr8:124371897C>T	uc003yqh.3	-	10	1294	c.1186G>A	c.(1186-1188)GAA>AAA	p.E396K	ATAD2_uc011lii.1_Missense_Mutation_p.E187K|ATAD2_uc003yqi.3_RNA|ATAD2_uc003yqj.2_Missense_Mutation_p.E396K	NM_014109	NP_054828	Q6PL18	ATAD2_HUMAN	ATPase family, AAA domain containing 2	396					regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrion|nucleus	ATP binding|ATPase activity			ovary(2)	2	Lung NSC(37;1.25e-09)|Ovarian(258;0.00838)		STAD - Stomach adenocarcinoma(47;0.00288)			CCTTTTAATTCATCTTTCCGA	0.358		NaN											0	0	0	0.021553	0	6	67									
FAM135B	51059	broad.mit.edu	37	8	139380157	139380157	+	Missense_Mutation	SNP	G	G	C			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr8:139380157G>C	uc003yuy.2	-	2	241	c.70C>G	c.(70-72)CAG>GAG	p.Q24E	FAM135B_uc003yux.2_5'UTR|FAM135B_uc003yuz.2_RNA	NM_015912	NP_056996	Q49AJ0	F135B_HUMAN	hypothetical protein LOC51059	24										ovary(7)|skin(2)	9	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			TACCCTCTCTGAAAGAGATCC	0.328		NaN								HNSCC(54;0.14)			0	0	0	0.139131	0	57	34									
MAPK15	225689	broad.mit.edu	37	8	144803252	144803252	+	Missense_Mutation	SNP	G	G	C			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr8:144803252G>C	uc003yzj.2	+	10	1041	c.1000G>C	c.(1000-1002)GAG>CAG	p.E334Q		NM_139021	NP_620590	Q8TD08	MK15_HUMAN	mitogen-activated protein kinase 15	334					protein autophosphorylation	extracellular region	ATP binding|MAP kinase activity|SH3 domain binding			lung(2)	2	all_cancers(97;3.74e-11)|all_epithelial(106;2.62e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;3.38e-41)|Epithelial(56;6.8e-40)|all cancers(56;6.43e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.146)			CTCTGTGCCTGAGTACCGCAG	0.652		NaN											0	0	0	0.014758	0	4	27									
MPDZ	8777	broad.mit.edu	37	9	13119644	13119644	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr9:13119644C>T	uc010mia.1	-	38	5293	c.5236G>A	c.(5236-5238)GAT>AAT	p.D1746N	MPDZ_uc003zkx.3_Missense_Mutation_p.D11N|MPDZ_uc003zky.3_Missense_Mutation_p.D280N|MPDZ_uc010mib.2_Missense_Mutation_p.D451N|MPDZ_uc010mhx.2_Missense_Mutation_p.D568N|MPDZ_uc011lmm.1_Missense_Mutation_p.D605N|MPDZ_uc003zkz.3_Missense_Mutation_p.D439N|MPDZ_uc010mhy.2_Missense_Mutation_p.D1746N|MPDZ_uc010mhz.2_Missense_Mutation_p.D1713N|MPDZ_uc011lmn.1_Missense_Mutation_p.D1713N|MPDZ_uc003zlb.3_Missense_Mutation_p.D1746N	NM_003829	NP_003820	O75970	MPDZ_HUMAN	multiple PDZ domain protein	1746	PDZ 11.				interspecies interaction between organisms	apical plasma membrane|dendrite|postsynaptic density|postsynaptic membrane|synaptosome|tight junction	protein C-terminus binding			ovary(5)|central_nervous_system(1)	6				GBM - Glioblastoma multiforme(50;2.03e-06)		ACTCCAGTATCGTTTCTACAC	0.348		NaN											0	0	0	0.047766	0	9	58									
PIGO	84720	broad.mit.edu	37	9	35094274	35094274	+	Silent	SNP	G	G	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr9:35094274G>T	uc003zwd.2	-	3	990	c.594C>A	c.(592-594)TCC>TCA	p.S198S	PIGO_uc003zwc.1_Silent_p.S198S|PIGO_uc003zwe.2_Silent_p.S198S|PIGO_uc003zwf.2_Silent_p.S198S|PIGO_uc003zwg.1_5'UTR	NM_032634	NP_116023	Q8TEQ8	PIGO_HUMAN	phosphatidylinositol glycan anchor biosynthesis,	198					C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane	transferase activity			large_intestine(1)|ovary(1)|skin(1)	3			LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00778)			TGACATTGAAGGATGGGAAGA	0.502		NaN											1	0	6.44725e-10	0.069288	6.81376e-10	12	32									
PIGO	84720	broad.mit.edu	37	9	35094283	35094283	+	Missense_Mutation	SNP	G	G	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr9:35094283G>T	uc003zwd.2	-	3	981	c.585C>A	c.(583-585)TTC>TTA	p.F195L	PIGO_uc003zwc.1_Missense_Mutation_p.F195L|PIGO_uc003zwe.2_Missense_Mutation_p.F195L|PIGO_uc003zwf.2_Missense_Mutation_p.F195L|PIGO_uc003zwg.1_5'UTR	NM_032634	NP_116023	Q8TEQ8	PIGO_HUMAN	phosphatidylinositol glycan anchor biosynthesis,	195					C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane	transferase activity			large_intestine(1)|ovary(1)|skin(1)	3			LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00778)			AGGATGGGAAGAAGAAAGCTT	0.498		NaN											1	0	4.35082e-09	0.055883	4.56278e-09	10	30									
PIGO	84720	broad.mit.edu	37	9	35094310	35094310	+	Silent	SNP	G	G	A			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr9:35094310G>A	uc003zwd.2	-	3	954	c.558C>T	c.(556-558)TTC>TTT	p.F186F	PIGO_uc003zwc.1_Silent_p.F186F|PIGO_uc003zwe.2_Silent_p.F186F|PIGO_uc003zwf.2_Silent_p.F186F|PIGO_uc003zwg.1_5'UTR	NM_032634	NP_116023	Q8TEQ8	PIGO_HUMAN	phosphatidylinositol glycan anchor biosynthesis,	186					C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane	transferase activity			large_intestine(1)|ovary(1)|skin(1)	3			LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00778)			AAGCACCAGGGAAAAGGTCTT	0.502		NaN											0	0	0	0.144211	0	20	31									
CREB3	10488	broad.mit.edu	37	9	35735135	35735135	+	Silent	SNP	G	G	C			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr9:35735135G>C	uc003zxv.2	+	5	918	c.465G>C	c.(463-465)CGG>CGC	p.R155R	TLN1_uc003zxt.2_5'Flank|TLN1_uc003zxu.3_5'Flank|CREB3_uc010mla.2_Silent_p.R74R	NM_006368	NP_006359	O43889	CREB3_HUMAN	cAMP responsive element binding protein 3	179	Cytoplasmic (Potential).|Basic motif.				chemotaxis|induction of positive chemotaxis|interspecies interaction between organisms|negative regulation of cell cycle|positive regulation of calcium ion transport|positive regulation of cell migration|positive regulation of transcription, DNA-dependent|reactivation of latent virus|regulation of cell proliferation	cytosol|endoplasmic reticulum|endoplasmic reticulum membrane|Golgi apparatus|integral to membrane|integral to membrane|nucleus|nucleus	cAMP response element binding protein binding|CCR1 chemokine receptor binding|DNA binding|protein dimerization activity|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|sequence-specific DNA binding transcription factor activity				0	all_epithelial(49;0.167)		Lung(28;0.00276)|LUSC - Lung squamous cell carcinoma(32;0.00418)|STAD - Stomach adenocarcinoma(86;0.194)	GBM - Glioblastoma multiforme(74;0.0285)		AACGTGTGCGGAGGAAGATTC	0.348		NaN											0	0	0	0.134883	0	30	28									
RASEF	158158	broad.mit.edu	37	9	85613323	85613323	+	Missense_Mutation	SNP	C	C	G			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr9:85613323C>G	uc004amo.1	-	13	2023	c.1762G>C	c.(1762-1764)GAA>CAA	p.E588Q		NM_152573	NP_689786	Q8IZ41	RASEF_HUMAN	RAS and EF-hand domain containing	588					protein transport|small GTPase mediated signal transduction	perinuclear region of cytoplasm	calcium ion binding|GTP binding			upper_aerodigestive_tract(1)|lung(1)|breast(1)	3						ACTGTTCGTTCTCCATCCACA	0.453		NaN											0	0	0	0.139131	0	179	84									
FOXE1	2304	broad.mit.edu	37	9	100617151	100617151	+	Missense_Mutation	SNP	G	G	C			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr9:100617151G>C	uc004axu.2	+	1	1615	c.955G>C	c.(955-957)GAG>CAG	p.E319Q		NM_004473	NP_004464	O00358	FOXE1_HUMAN	forkhead box E1	319					cell migration|embryonic organ morphogenesis|hair follicle morphogenesis|hard palate development|lens morphogenesis in camera-type eye|negative regulation of transcription from RNA polymerase II promoter|pattern specification process|peripheral nervous system development|pharynx development|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity|soft palate development|thymus development|thyroid gland development|thyroid hormone generation	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding				0		Acute lymphoblastic leukemia(62;0.158)				TGGCGGCGTGGAGACCACGGT	0.751		NaN											0	0	0	0.069234	0	8	3									
C9orf156	51531	broad.mit.edu	37	9	100667150	100667150	+	Missense_Mutation	SNP	G	G	C			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr9:100667150G>C	uc004axv.1	-	5	1268	c.1191C>G	c.(1189-1191)TTC>TTG	p.F397L	C9orf156_uc004axw.1_Missense_Mutation_p.F294L|C9orf156_uc004axx.1_Missense_Mutation_p.F251L	NM_016481	NP_057565	Q9BU70	NAP1_HUMAN	Nef associated protein 1	397					interspecies interaction between organisms		hydrolase activity				0		Acute lymphoblastic leukemia(62;0.158)				CAGTAAAGTAGAAAAGGCGGT	0.527		NaN											0	0	0	0.139131	0	72	76									
OR13C8	138802	broad.mit.edu	37	9	107332253	107332253	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr9:107332253G>A	uc011lvo.1	+	1	805	c.805G>A	c.(805-807)GAT>AAT	p.D269N		NM_001004483	NP_001004483	Q8NGS7	O13C8_HUMAN	olfactory receptor, family 13, subfamily C,	269	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						AGCCTCTGTTGATTCAGGTAA	0.453		NaN											0	0	0	0.086207	0	39	85									
EXD3	54932	broad.mit.edu	37	9	140250821	140250821	+	Splice_Site	SNP	C	C	G			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr9:140250821C>G	uc004cmp.2	-	8	853	c.657_splice	c.e8-1	p.R219_splice	C9orf167_uc011mew.1_Intron|EXD3_uc010ncf.1_Splice_Site|EXD3_uc004cmq.1_Splice_Site|EXD3_uc010ncg.1_Splice_Site_p.R158_splice	NM_017820	NP_060290	Q8N9H8	MUT7_HUMAN	exonuclease 3'-5' domain containing 3						nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	intracellular	3'-5' exonuclease activity|nucleic acid binding				0						AGGGTACCGTCTGTGGGGAGA	0.438		NaN											0	0	0	0.021553	0	6	8									
NYX	60506	broad.mit.edu	37	X	41333009	41333009	+	Missense_Mutation	SNP	C	C	G			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chrX:41333009C>G	uc004dfh.2	+	2	733	c.303C>G	c.(301-303)ATC>ATG	p.I101M	NYX_uc011mku.1_Missense_Mutation_p.I96M	NM_022567	NP_072089	Q9GZU5	NYX_HUMAN	nyctalopin precursor	101	LRR 2.		Missing (in CSNB1A).		response to stimulus|visual perception	intracellular|proteinaceous extracellular matrix				lung(2)	2						TGTCCTTCATCACGCCCGGCG	0.716		NaN											0	0	0	0.115264	0	2	6									
CHST7	56548	broad.mit.edu	37	X	46433799	46433799	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chrX:46433799G>A	uc004dgt.2	+	1	608	c.433G>A	c.(433-435)GAC>AAC	p.D145N		NM_019886	NP_063939	Q9NS84	CHST7_HUMAN	chondroitin 6-sulfotransferase 7	145	Lumenal (Potential).				chondroitin sulfate biosynthetic process|N-acetylglucosamine metabolic process	Golgi membrane|integral to membrane	chondroitin 6-sulfotransferase activity|N-acetylglucosamine 6-O-sulfotransferase activity			breast(3)	3						GTATCCGGGCGACGCCGAGAG	0.557		NaN											0	0	0	0.064281	0	33	16									
GNL3L	54552	broad.mit.edu	37	X	54578731	54578731	+	Missense_Mutation	SNP	G	G	C			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chrX:54578731G>C	uc004dth.1	+	13	1327	c.1188G>C	c.(1186-1188)AAG>AAC	p.K396N	GNL3L_uc004dti.2_RNA	NM_019067	NP_061940	Q9NVN8	GNL3L_HUMAN	guanine nucleotide binding protein-like 3	396					ribosome biogenesis	nucleolus	GTP binding			ovary(1)	1						GCAGCGGGAAGATCAGCTTCT	0.502		NaN											0	0	0	0.038395	0	18	55									
UPRT	139596	broad.mit.edu	37	X	74494400	74494400	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chrX:74494400G>A	uc004ecb.1	+	1	440	c.311G>A	c.(310-312)CGG>CAG	p.R104Q	UPRT_uc010nlu.1_Missense_Mutation_p.R104Q|UPRT_uc004ecc.1_RNA|UPRT_uc004ecd.1_Missense_Mutation_p.R104Q|UPRT_uc004ece.1_5'Flank	NM_145052	NP_659489	Q96BW1	UPP_HUMAN	uracil phosphoribosyltransferase (FUR1) homolog	104					nucleoside metabolic process	cytoplasm|nucleus					0						GAACTCTCCCGGCAGATCGGG	0.562		NaN											0	0	0	0.009096	0	4	7									
C1GALT1C1	29071	broad.mit.edu	37	X	119760538	119760538	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chrX:119760538C>T	uc004esy.2	-	3	831	c.484G>A	c.(484-486)GAT>AAT	p.D162N	C1GALT1C1_uc004esz.2_Missense_Mutation_p.D162N	NM_152692	NP_689905	Q96EU7	C1GLC_HUMAN	C1GALT1-specific chaperone 1	162	Lumenal (Potential).					integral to membrane					0						TGTGATGGATCCTTTTTTAAC	0.383		NaN											0	0	0	0.116897	0	27	46									
MAGEC2	51438	broad.mit.edu	37	X	141291225	141291225	+	Missense_Mutation	SNP	C	C	G			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chrX:141291225C>G	uc004fbu.1	-	3	897	c.549G>C	c.(547-549)AAG>AAC	p.K183N		NM_016249	NP_057333	Q9UBF1	MAGC2_HUMAN	melanoma antigen family C, 2	183	MAGE.					cytoplasm|nucleus				breast(2)	2	Acute lymphoblastic leukemia(192;6.56e-05)					CACGGGCTCTCTTGAGTATCA	0.483		NaN								HNSCC(46;0.14)			0	0	0	0.139131	0	112	73									
TMLHE	55217	broad.mit.edu	37	X	154736681	154736681	+	Silent	SNP	G	G	A			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chrX:154736681G>A	uc004fnn.2	-	6	1039	c.873C>T	c.(871-873)CTC>CTT	p.L291L	TMLHE_uc004fno.2_Silent_p.L291L|TMLHE_uc004fnp.3_Silent_p.L291L	NM_018196	NP_060666	Q9NVH6	TMLH_HUMAN	trimethyllysine hydroxylase, epsilon	291					carnitine biosynthetic process	mitochondrial matrix	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|trimethyllysine dioxygenase activity			ovary(1)	1	all_cancers(53;1.86e-17)|all_epithelial(53;2.71e-11)|all_lung(58;1.84e-07)|Lung NSC(58;5.62e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)				Succinic acid(DB00139)|Vitamin C(DB00126)	CTTTACTGAGGAGTTCAAATT	0.418		NaN											0	0	0	0.139131	0	90	48									
IQGAP3	128239	broad.mit.edu	37	1	156530742	156530743	+	Frame_Shift_Ins	INS	-	-	C			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr1:156530742_156530743insC	uc001fpf.2	-	11	1187_1188	c.1112_1113insG	c.(1111-1113)GGTfs	p.G371fs	IQGAP3_uc009wsb.1_Frame_Shift_Ins_p.G328fs	NM_178229	NP_839943	Q86VI3	IQGA3_HUMAN	IQ motif containing GTPase activating protein 3	371					small GTPase mediated signal transduction	intracellular	calmodulin binding|Ras GTPase activator activity			ovary(5)|skin(1)	6	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					GTTCCTGATCACCCTTTGTGTT	0.525		NaN											NaN	NaN	NaN	NaN	NaN	7	113	---	---							
CPXM2	119587	broad.mit.edu	37	10	125528165	125528167	+	In_Frame_Del	DEL	CAG	CAG	-			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr10:125528165_125528167delCAG	uc001lhk.1	-	9	1499_1501	c.1174_1176delCTG	c.(1174-1176)CTGdel	p.L392del	CPXM2_uc001lhj.2_RNA	NM_198148	NP_937791	Q8N436	CPXM2_HUMAN	carboxypeptidase X (M14 family), member 2	392	Poly-Leu.				cell adhesion|proteolysis	extracellular space	metallocarboxypeptidase activity|zinc ion binding			ovary(2)	2		all_lung(145;0.174)|Colorectal(57;0.178)|Glioma(114;0.222)|all_neural(114;0.226)|Lung NSC(174;0.233)		COAD - Colon adenocarcinoma(40;0.212)|Colorectal(40;0.237)		CGAACTGCACCAGCAGCAGCAGC	0.626		NaN											NaN	NaN	NaN	NaN	NaN	7	154	---	---							
PCNXL3	399909	broad.mit.edu	37	11	65393419	65393421	+	In_Frame_Del	DEL	CTT	CTT	-			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr11:65393419_65393421delCTT	uc001oey.2	+	20	3273_3275	c.3273_3275delCTT	c.(3271-3276)GGCTTC>GGC	p.F1093del	PCNXL3_uc009yqn.2_In_Frame_Del_p.F53del|PCNXL3_uc001oez.2_5'Flank	NM_032223	NP_115599	Q9H6A9	PCX3_HUMAN	pecanex-like 3	1093	Helical; (Potential).					integral to membrane					0						GGGCCGTGGGCTTCTTCACACAT	0.606		NaN									OREG0021084	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	NaN	NaN	NaN	NaN	NaN	9	26	---	---							
RB1	5925	broad.mit.edu	37	13	49037882	49037897	+	Frame_Shift_Del	DEL	ATGTATGGCATATGCA	ATGTATGGCATATGCA	-	rs137853296		TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08			ATGTATGGCATATGCA	-	ATGTATGGCATATGCA	ATGTATGGCATATGCA		Valid	Somatic	Phase_I	WXS	Fluidigm_realigned			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr13:49037882_49037897delATGTATGGCATATGCA	uc001vcb.2	+	21	2288_2303	c.2122_2137delATGTATGGCATATGCA	c.(2122-2139)ATGTATGGCATATGCAAAfs	p.M708fs		NM_000321	NP_000312	P06400	RB_HUMAN	retinoblastoma 1	708_713	Pocket; binds T and E1A.|Domain B.				androgen receptor signaling pathway|cell cycle arrest|chromatin remodeling|G1 phase of mitotic cell cycle|interspecies interaction between organisms|maintenance of mitotic sister chromatid cohesion|mitotic cell cycle G1/S transition checkpoint|myoblast differentiation|negative regulation of cell growth|negative regulation of protein kinase activity|negative regulation of S phase of mitotic cell cycle|negative regulation of sequence-specific DNA binding transcription factor activity|positive regulation of mitotic metaphase/anaphase transition|protein localization to chromosome, centromeric region|Ras protein signal transduction|regulation of centromere complex assembly|regulation of cohesin localization to chromatin|regulation of lipid kinase activity|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle|sister chromatid biorientation	chromatin|PML body|Rb-E2F complex|SWI/SNF complex	androgen receptor binding|DNA binding|kinase binding|phosphoprotein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription factor binding|ubiquitin protein ligase binding	p.?(6)|p.I703_E737del(2)|p.C712_A727del(1)		lung(94)|eye(89)|central_nervous_system(47)|bone(22)|breast(21)|urinary_tract(17)|haematopoietic_and_lymphoid_tissue(14)|ovary(10)|prostate(9)|soft_tissue(8)|skin(7)|endometrium(5)|cervix(3)|liver(3)|salivary_gland(2)|stomach(2)|oesophagus(1)|adrenal_gland(1)|kidney(1)|gastrointestinal_tract_(site_indeterminate)(1)|pituitary(1)	358		all_cancers(8;6.9e-71)|all_epithelial(8;4.61e-22)|Acute lymphoblastic leukemia(8;1.1e-21)|all_hematologic(8;2.3e-21)|all_lung(13;1.51e-09)|Lung NSC(96;7.03e-07)|Breast(56;1.53e-05)|Prostate(109;0.000493)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|all_neural(104;0.0227)|Glioma(44;0.0286)|Lung SC(185;0.0301)		GBM - Glioblastoma multiforme(2;9.98e-18)|LUSC - Lung squamous cell carcinoma(3;0.013)	Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	GATGTGTTCCATGTATGGCATATGCAAAGTGAAGAA	0.296		6	D|Mis|N|F|S		retinoblastoma|sarcoma|breast|small cell lung	retinoblastoma|sarcoma|breast|small cell lung			Hereditary_Retinoblastoma	TCGA GBM(7;6.82e-08)|TSP Lung(12;0.097)|TCGA Ovarian(6;0.080)			NaN	NaN	NaN	NaN	NaN	8	36	---	---							
OR4N4	283694	broad.mit.edu	37	15	22382920	22382921	+	Frame_Shift_Ins	INS	-	-	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr15:22382920_22382921insT	uc001yuc.1	+	7	1429_1430	c.448_449insT	c.(448-450)CTTfs	p.L150fs	LOC727924_uc001yub.1_Intron|OR4N4_uc010tzv.1_Frame_Shift_Ins_p.L150fs	NM_001005241	NP_001005241	Q8N0Y3	OR4N4_HUMAN	olfactory receptor, family 4, subfamily N,	150	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(4)|skin(1)	5		all_cancers(20;1.94e-20)|all_epithelial(15;3.94e-18)|Lung NSC(15;8.53e-15)|all_lung(15;2.87e-14)|Breast(32;0.00519)|Colorectal(260;0.101)	GBM - Glioblastoma multiforme(6;0.124)	all cancers(64;1.64e-11)|Epithelial(43;5.81e-10)|BRCA - Breast invasive adenocarcinoma(123;0.000255)|Kidney(6;0.00736)|KIRC - Kidney renal clear cell carcinoma(6;0.0135)|GBM - Glioblastoma multiforme(186;0.0963)		GGCTCTGTGGCTTGGGGGTTTT	0.535		NaN											NaN	NaN	NaN	NaN	NaN	23	132	---	---							
SPRED3	399473	broad.mit.edu	37	19	38882864	38882866	+	In_Frame_Del	DEL	CCT	CCT	-			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr19:38882864_38882866delCCT	uc002oim.2	+	3	363_365	c.359_361delCCT	c.(358-363)CCCTCC>CCC	p.S128del	SPRED3_uc002oil.1_In_Frame_Del_p.S128del	NM_001042522	NP_001035987	Q2MJR0	SPRE3_HUMAN	sprouty-related, EVH1 domain containing 3	128	Ser-rich.				multicellular organismal development					central_nervous_system(2)|lung(1)|skin(1)	4	all_cancers(60;3.4e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)			TCACTCAccccctcctcctcctc	0.537		NaN											NaN	NaN	NaN	NaN	NaN	7	46	---	---							
MMP9	4318	broad.mit.edu	37	20	44639945	44639945	+	Frame_Shift_Del	DEL	C	C	-			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr20:44639945delC	uc002xqz.2	+	5	832	c.813delC	c.(811-813)TGCfs	p.C271fs		NM_004994	NP_004985	P14780	MMP9_HUMAN	matrix metalloproteinase 9 preproprotein	271	Fibronectin type-II 1.				collagen catabolic process|macrophage differentiation|positive regulation of keratinocyte migration|proteolysis	extracellular space|proteinaceous extracellular matrix	collagen binding|metalloendopeptidase activity|zinc ion binding			ovary(1)|pancreas(1)	2		Myeloproliferative disorder(115;0.0122)			Glucosamine(DB01296)|Marimastat(DB00786)|Minocycline(DB01017)|Simvastatin(DB00641)	TTGGCTTCTGCCCCAGCGAGA	0.552		NaN											NaN	NaN	NaN	NaN	NaN	39	82	---	---							
ANXA6	309	broad.mit.edu	37	5	150515861	150515861	+	Frame_Shift_Del	DEL	C	C	-			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr5:150515861delC	uc003ltl.1	-	7	597	c.445delG	c.(445-447)GACfs	p.D149fs	ANXA6_uc011dcp.1_Frame_Shift_Del_p.D117fs|ANXA6_uc003ltm.1_Frame_Shift_Del_p.D149fs|ANXA6_uc003ltn.1_Intron|ANXA6_uc003lto.1_Intron	NM_001155	NP_001146	P08133	ANXA6_HUMAN	annexin VI isoform 1	149	Annexin 2.					melanosome	calcium ion binding|calcium-dependent phospholipid binding|protein binding				0		Medulloblastoma(196;0.0912)|all_hematologic(541;0.208)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			CCAGAGGTGTCGCCGATGATG	0.547		NaN											NaN	NaN	NaN	NaN	NaN	27	34	---	---