Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	isArtifactMode	oxoGCut	pox	pox_cutoff	qox	t_alt_count	t_ref_count	validation_alt_allele	validation_tumor_sample							
C8A	731	broad.mit.edu	37	1	57373628	57373628	+	Splice_Site	SNP	G	G	A			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr1:57373628G>A	uc001cyo.2	+	9	1355	c.1223_splice	c.e9-1	p.E408_splice		NM_000562	NP_000553	P07357	CO8A_HUMAN	complement component 8, alpha polypeptide						complement activation, alternative pathway|complement activation, classical pathway|cytolysis	extracellular space|membrane attack complex				ovary(1)|central_nervous_system(1)|skin(1)	3						CTTGATGGCAGAAAGGGCCAG	0.488		NaN											0	0	0	0.049695	0	14	38									
OR6N2	81442	broad.mit.edu	37	1	158746645	158746645	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr1:158746645G>A	uc010pir.1	-	1	781	c.781C>T	c.(781-783)CGG>TGG	p.R261W		NM_001005278	NP_001005278	Q8NGY6	OR6N2_HUMAN	olfactory receptor, family 6, subfamily N,	261	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_hematologic(112;0.0378)					TTCTTTAGCCGCACATACATG	0.433		NaN											0	0	0	0.09319	0	12	38									
DNM3	26052	broad.mit.edu	37	1	171890908	171890908	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr1:171890908C>T	uc001gie.2	+	2	358	c.182C>T	c.(181-183)TCG>TTG	p.S61L	DNM3_uc001gid.3_Missense_Mutation_p.S61L|DNM3_uc009wwb.2_Missense_Mutation_p.S61L|DNM3_uc001gif.2_Missense_Mutation_p.S61L	NM_015569	NP_056384	Q9UQ16	DYN3_HUMAN	dynamin 3 isoform a	61					endocytosis|filopodium assembly|synapse assembly	dendritic spine|microtubule|perinuclear region of cytoplasm|postsynaptic density	GTP binding|GTPase activity|protein binding			breast(1)	1						CCTCGAGGGTCGGGCATTGTA	0.433		NaN											0	0	0	0.080935	0	9	10									
PROX1	5629	broad.mit.edu	37	1	214184960	214184960	+	Missense_Mutation	SNP	A	A	C			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr1:214184960A>C	uc001hkh.2	+	4	2202	c.1930A>C	c.(1930-1932)AAC>CAC	p.N644H		NM_002763	NP_002754	Q92786	PROX1_HUMAN	prospero homeobox 1	644	Prospero-like.				aorta smooth muscle tissue morphogenesis|atrial cardiac muscle tissue morphogenesis|brain development|dorsal spinal cord development|embryonic retina morphogenesis in camera-type eye|endocardium formation|hepatocyte differentiation|kidney development|lens fiber cell morphogenesis|lung development|lymphangiogenesis|negative regulation of bile acid biosynthetic process|negative regulation of cell proliferation|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of viral genome replication|neural tube development|olfactory placode formation|optic placode formation involved in camera-type eye formation|otic placode formation|pancreas development|positive regulation of cyclin-dependent protein kinase activity|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of heart growth|positive regulation of S phase of mitotic cell cycle|positive regulation of sarcomere organization|positive regulation of transcription, DNA-dependent|regulation of transcription involved in lymphatic endothelial cell fate commitment|skeletal muscle thin filament assembly|venous blood vessel morphogenesis|ventricular cardiac muscle tissue morphogenesis|ventricular cardiac myofibril development|ventricular septum morphogenesis	cytoplasm|nucleus	DBD domain binding|LBD domain binding|ligand-dependent nuclear receptor binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription corepressor activity|transcription regulatory region DNA binding			ovary(3)|lung(1)|central_nervous_system(1)|skin(1)	6				OV - Ovarian serous cystadenocarcinoma(81;0.0179)|all cancers(67;0.0488)|GBM - Glioblastoma multiforme(131;0.188)|Epithelial(68;0.219)		TCAAGCCATCAACGATGGGGT	0.443		NaN											0	0	0	0.139131	0	64	8									
ANKRD30A	91074	broad.mit.edu	37	10	37430773	37430773	+	Silent	SNP	G	G	A			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr10:37430773G>A	uc001iza.1	+	7	879	c.780G>A	c.(778-780)ACG>ACA	p.T260T		NM_052997	NP_443723	Q9BXX3	AN30A_HUMAN	ankyrin repeat domain 30A	316						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(7)|breast(1)|skin(1)	9						CACCTGACACGGCTGAAAGCT	0.493		NaN											0	0	0	0.115264	0	3	51									
KIF11	3832	broad.mit.edu	37	10	94405356	94405356	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr10:94405356C>G	uc001kic.2	+	18	2812	c.2504C>G	c.(2503-2505)TCT>TGT	p.S835C	KIF11_uc010qnq.1_Intron	NM_004523	NP_004514	P52732	KIF11_HUMAN	kinesin family member 11	835					blood coagulation|cell division|microtubule-based movement|spindle assembly involved in mitosis	chromatin remodeling complex|cytosol|kinesin complex|microtubule|spindle pole	ATP binding|microtubule motor activity|protein kinase binding			skin(1)	1						CAGTGGGTATCTTCCTTAAAT	0.343		NaN											0	0	0	0.0333	0	14	20									
PGAM1	5223	broad.mit.edu	37	10	99190742	99190742	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr10:99190742C>G	uc001knh.2	+	3	483	c.445C>G	c.(445-447)CAG>GAG	p.Q149E	PGAM1_uc009xvo.2_Intron|PGAM1_uc010qov.1_Missense_Mutation_p.Q134E	NM_002629	NP_002620	P18669	PGAM1_HUMAN	phosphoglycerate mutase 1	149					gluconeogenesis|glycolysis|regulation of glycolysis|regulation of pentose-phosphate shunt|respiratory burst	cytosol	2,3-bisphospho-D-glycerate 2-phosphohydrolase activity|bisphosphoglycerate mutase activity|phosphoglycerate mutase activity|protein kinase binding				0		Colorectal(252;0.162)		Epithelial(162;8.36e-10)|all cancers(201;5.62e-08)		CACAGAAGATCAGCTACCCTC	0.433		NaN											0	0	0	0.0918	0	15	28									
SEC23IP	11196	broad.mit.edu	37	10	121663630	121663630	+	Silent	SNP	G	G	A			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr10:121663630G>A	uc001leu.1	+	4	1014	c.942G>A	c.(940-942)ACG>ACA	p.T314T	SEC23IP_uc010qtc.1_Silent_p.T103T	NM_007190	NP_009121	Q9Y6Y8	S23IP_HUMAN	Sec23-interacting protein p125	314	Interaction with SEC23A.				Golgi organization|intracellular protein transport	endoplasmic reticulum|ER to Golgi transport vesicle membrane|ER-Golgi intermediate compartment	metal ion binding			ovary(3)	3		Lung NSC(174;0.109)|all_lung(145;0.142)|all_neural(114;0.234)		all cancers(201;0.00515)		TTCTTGGCACGGATGGAGGGC	0.453		NaN											0	0	0	0.014758	0	4	53									
KRTAP5-5	439915	broad.mit.edu	37	11	1651442	1651442	+	Silent	SNP	G	G	T			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr11:1651442G>T	uc001lty.2	+	1	410	c.372G>T	c.(370-372)GGG>GGT	p.G124G		NM_001001480	NP_001001480	Q701N2	KRA55_HUMAN	keratin associated protein 5-5	124	8 X 4 AA repeats of C-C-X-P.					keratin filament				lung(1)	1		all_epithelial(84;0.00018)|Ovarian(85;0.0014)|Breast(177;0.00147)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.000614)|Lung(200;0.0681)|LUSC - Lung squamous cell carcinoma(625;0.082)		CCTGTGGGGGGTCCAAGGGGG	0.692		NaN											1	0	0.00116845	0.021553	0.00122948	3	21									
KRTAP5-5	439915	broad.mit.edu	37	11	1651459	1651459	+	Missense_Mutation	SNP	G	G	T			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr11:1651459G>T	uc001lty.2	+	1	427	c.389G>T	c.(388-390)GGC>GTC	p.G130V		NM_001001480	NP_001001480	Q701N2	KRA55_HUMAN	keratin associated protein 5-5	130	8 X 4 AA repeats of C-C-X-P.					keratin filament				lung(1)	1		all_epithelial(84;0.00018)|Ovarian(85;0.0014)|Breast(177;0.00147)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.000614)|Lung(200;0.0681)|LUSC - Lung squamous cell carcinoma(625;0.082)		GGGGGCTGTGGCTCCTGTGGG	0.692		NaN											1	0	0.00116845	0.021553	0.00122948	3	18									
NUP98	4928	broad.mit.edu	37	11	3794864	3794864	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr11:3794864C>G	uc001lyh.2	-	6	892	c.601G>C	c.(601-603)GAG>CAG	p.E201Q	NUP98_uc001lyi.2_Missense_Mutation_p.E201Q|NUP98_uc001lyj.1_Missense_Mutation_p.E201Q|NUP98_uc001lyk.1_Missense_Mutation_p.E201Q|NUP98_uc010qxv.1_Missense_Mutation_p.E164Q	NM_016320	NP_057404	P52948	NUP98_HUMAN	nucleoporin 98kD isoform 1	201	Gly/Thr-rich.				carbohydrate metabolic process|DNA replication|glucose transport|interspecies interaction between organisms|mitotic prometaphase|mRNA transport|nuclear pore organization|protein import into nucleus, docking|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear membrane|nucleoplasm|Nup107-160 complex	protein binding|structural constituent of nuclear pore|transporter activity			breast(4)|skin(3)|ovary(2)|central_nervous_system(1)|lung(1)|kidney(1)	12		Medulloblastoma(188;0.0025)|Breast(177;0.00328)|all_neural(188;0.0227)		BRCA - Breast invasive adenocarcinoma(625;0.0403)|LUSC - Lung squamous cell carcinoma(625;0.116)|Lung(200;0.199)		TTACTGACCTCTAGTGACTTG	0.343		NaN	T	HOXA9|NSD1|WHSC1L1|DDX10|TOP1|HOXD13|PMX1|HOXA13|HOXD11|HOXA11|RAP1GDS1|HOXC11	AML								0	0	0	0.105934	0	11	8									
OR52B6	340980	broad.mit.edu	37	11	5602231	5602231	+	Missense_Mutation	SNP	A	A	C			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr11:5602231A>C	uc010qzi.1	+	1	125	c.125A>C	c.(124-126)CAA>CCA	p.Q42P	HBG2_uc001mak.1_Intron	NM_001005162	NP_001005162	Q8NGF0	O52B6_HUMAN	olfactory receptor, family 52, subfamily B,	42	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		Medulloblastoma(188;0.00225)|Breast(177;0.0204)|all_neural(188;0.0212)		Epithelial(150;3.56e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GGGCTGGAGCAACTACATATC	0.502		NaN											0	0	0	0.038147	0	7	12									
OR5A2	219981	broad.mit.edu	37	11	59189895	59189895	+	Missense_Mutation	SNP	A	A	C			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr11:59189895A>C	uc010rkt.1	-	1	532	c.532T>G	c.(532-534)TTT>GTT	p.F178V		NM_001001954	NP_001001954	Q8NGI9	OR5A2_HUMAN	olfactory receptor, family 5, subfamily A,	178	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						TCACAGAAAAAGTGGTTGATC	0.483		NaN											0	0	0	0.009096	0	3	65									
OR6X1	390260	broad.mit.edu	37	11	123624493	123624493	+	Missense_Mutation	SNP	A	A	G			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr11:123624493A>G	uc010rzy.1	-	1	734	c.734T>C	c.(733-735)GTT>GCT	p.V245A		NM_001005188	NP_001005188	Q8NH79	OR6X1_HUMAN	olfactory receptor, family 6, subfamily X,	245	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3		Breast(109;0.0109)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0279)		CAGGGAGACAACTGTCAGGTG	0.453		NaN											0	0	0	0.09319	0	13	22									
SLC37A2	219855	broad.mit.edu	37	11	124952197	124952197	+	Missense_Mutation	SNP	C	C	A			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr11:124952197C>A	uc001qbn.2	+	10	1194	c.943C>A	c.(943-945)CTC>ATC	p.L315I	SLC37A2_uc010sau.1_Missense_Mutation_p.L315I|SLC37A2_uc010sav.1_5'Flank|SLC37A2_uc001qbp.2_5'Flank	NM_001145290	NP_001138762	Q8TED4	SPX2_HUMAN	solute carrier family 37 (glycerol-3-phosphate	315	Helical; (Potential).				carbohydrate transport|transmembrane transport	integral to membrane				ovary(2)	2	all_hematologic(175;0.215)	Breast(109;0.012)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.152)|all_lung(97;0.159)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.61e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0384)		TTACACCTTCCTCTACTGGCT	0.587		NaN											1	0	9.45814e-24	0.074837	1.06688e-23	30	48									
PRB1	5542	broad.mit.edu	37	12	11506602	11506602	+	Silent	SNP	T	T	C			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr12:11506602T>C	uc001qzw.1	-	3	472	c.435A>G	c.(433-435)GGA>GGG	p.G145G	PRB1_uc001qzu.1_Intron|PRB1_uc001qzv.1_Intron	NM_005039	NP_005030	P04280	PRP1_HUMAN	proline-rich protein BstNI subfamily 1 isoform 1	206	15 X 20 AA approximate tandem repeats of P-P-G-K-P-Q-G-P-P-[PAQ]-Q-[GE]-[GD]- [NKS]-[KSQRN]-[PRQS]-[QS] [GPS]-[PQAR]- [PSR].|8.		Missing (in clone CP-4).|Missing (in clone CP-5).|Missing (in allele S).			extracellular region					0			OV - Ovarian serous cystadenocarcinoma(49;0.185)			GGGACTTGTCTCCTTGTGGGG	0.607		NaN											0	0	0	0.009096	0	4	144									
BCL2L14	79370	broad.mit.edu	37	12	12232321	12232321	+	Missense_Mutation	SNP	G	G	A	rs142096906	byFrequency	TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr12:12232321G>A	uc001rac.2	+	2	283	c.82G>A	c.(82-84)GCC>ACC	p.A28T	ETV6_uc001raa.1_Intron|BCL2L14_uc001raf.1_RNA|BCL2L14_uc001rad.2_Missense_Mutation_p.A28T|BCL2L14_uc001rae.2_Missense_Mutation_p.A28T	NM_138723	NP_620049	Q9BZR8	B2L14_HUMAN	BCL2-like 14 isoform 1	28					apoptosis|regulation of apoptosis	cytosol|endomembrane system|intracellular organelle|membrane	protein binding			skin(1)	1		Prostate(47;0.0872)		BRCA - Breast invasive adenocarcinoma(232;0.154)		CAAAATCCTCGCCTACTACAC	0.488		NaN											0	0	0	0.083992	0	22	29									
PAN2	9924	broad.mit.edu	37	12	56716212	56716212	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr12:56716212C>T	uc001skx.2	-	19	3077	c.2704G>A	c.(2704-2706)GAT>AAT	p.D902N	PAN2_uc001skw.2_Missense_Mutation_p.D50N|PAN2_uc001skz.2_Missense_Mutation_p.D901N|PAN2_uc001sky.2_Missense_Mutation_p.D898N	NM_001127460	NP_001120932	Q504Q3	PAN2_HUMAN	PAN2 polyA specific ribonuclease subunit homolog	902					nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA poly(A) tail shortening|ubiquitin-dependent protein catabolic process	cytosol|nucleus	nucleic acid binding|poly(A)-specific ribonuclease activity|ubiquitin thiolesterase activity			ovary(2)|skin(2)|large_intestine(1)|breast(1)	6						CTAACCTTATCAATAGGTTCA	0.408		NaN											0	0	0	0.132662	0	12	42									
MTMR6	9107	broad.mit.edu	37	13	25840079	25840079	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr13:25840079C>T	uc001uqf.3	-	5	788	c.469G>A	c.(469-471)GAA>AAA	p.E157K	MTMR6_uc001uqe.1_Missense_Mutation_p.E157K	NM_004685	NP_004676	Q9Y217	MTMR6_HUMAN	myotubularin related protein 6	157	Myotubularin phosphatase.					cytoplasm|nuclear envelope	calcium-activated potassium channel activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity			ovary(2)|skin(2)	4		Lung SC(185;0.0225)|Breast(139;0.0351)		all cancers(112;0.00927)|Epithelial(112;0.0474)|OV - Ovarian serous cystadenocarcinoma(117;0.164)		GGGTAAGTTTCACAAATCTGT	0.353		NaN											0	0	0	0.09319	0	11	17									
AKAP11	11215	broad.mit.edu	37	13	42876628	42876628	+	Nonsense_Mutation	SNP	C	C	G			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr13:42876628C>G	uc001uys.1	+	8	3921	c.3746C>G	c.(3745-3747)TCA>TGA	p.S1249*		NM_016248	NP_057332	Q9UKA4	AKA11_HUMAN	A-kinase anchor protein 11	1249					intracellular protein kinase cascade	microtubule organizing center	protein kinase A binding|protein phosphatase 1 binding			ovary(1)|central_nervous_system(1)	2		Lung NSC(96;1.86e-05)|Prostate(109;0.0165)|Lung SC(185;0.0262)|Breast(139;0.0707)|Hepatocellular(98;0.114)		OV - Ovarian serous cystadenocarcinoma(117;0.000365)|GBM - Glioblastoma multiforme(144;0.00116)|BRCA - Breast invasive adenocarcinoma(63;0.19)		TTAAACCCCTCAGACGAAAAT	0.363		NaN											0	0	0	0.038395	0	16	5									
IRS2	8660	broad.mit.edu	37	13	110436504	110436504	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr13:110436504C>T	uc001vqv.2	-	1	2411	c.1897G>A	c.(1897-1899)GGA>AGA	p.G633R		NM_003749	NP_003740	Q9Y4H2	IRS2_HUMAN	insulin receptor substrate 2	633					fibroblast growth factor receptor signaling pathway|glucose metabolic process|insulin receptor signaling pathway|lipid homeostasis|negative regulation of B cell apoptosis|negative regulation of kinase activity|negative regulation of plasma membrane long-chain fatty acid transport|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of B cell proliferation|positive regulation of fatty acid beta-oxidation|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of insulin secretion|response to glucose stimulus	cytosol|plasma membrane	insulin receptor binding|signal transducer activity			large_intestine(2)|lung(2)|upper_aerodigestive_tract(1)|skin(1)|ovary(1)|kidney(1)	8	all_cancers(4;7.57e-15)|all_epithelial(4;5.91e-09)|all_lung(23;7.64e-07)|Lung NSC(43;0.000183)|Colorectal(4;0.00159)|all_neural(89;0.00294)|Medulloblastoma(90;0.00596)|Lung SC(71;0.0155)	Breast(118;0.159)	all cancers(43;0.00815)|BRCA - Breast invasive adenocarcinoma(86;0.11)|Epithelial(84;0.127)|GBM - Glioblastoma multiforme(44;0.147)			TCGATGTCTCCGTAGTCCTCT	0.711		NaN											0	0	0	0.047766	0	5	5									
HOMEZ	57594	broad.mit.edu	37	14	23746018	23746018	+	Missense_Mutation	SNP	G	G	T			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr14:23746018G>T	uc001wja.2	-	2	567	c.419C>A	c.(418-420)TCT>TAT	p.S140Y	HOMEZ_uc001wjb.2_Missense_Mutation_p.S142Y	NM_020834	NP_065885	Q8IX15	HOMEZ_HUMAN	homeodomain leucine zipper protein	140						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0	all_cancers(95;5.54e-06)			GBM - Glioblastoma multiforme(265;0.00643)		ATGAGTAAAAGAGAGAAGGGA	0.537		NaN											1	0	1.58521e-26	0.080422	1.80253e-26	34	89									
TGM1	7051	broad.mit.edu	37	14	24731538	24731538	+	Silent	SNP	G	G	A	rs150913268	by1000genomes	TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr14:24731538G>A	uc001wod.2	-	2	145	c.21C>T	c.(19-21)TCC>TCT	p.S7S	TGM1_uc010tog.1_5'UTR	NM_000359	NP_000350	P22735	TGM1_HUMAN	transglutaminase 1	7	Membrane anchorage region.				cell envelope organization|keratinization|peptide cross-linking	cornified envelope|intrinsic to membrane	acyltransferase activity|metal ion binding|protein binding|protein-glutamine gamma-glutamyltransferase activity			central_nervous_system(2)|ovary(1)	3				GBM - Glioblastoma multiforme(265;0.0186)	L-Glutamine(DB00130)	GGCCCACATCGGAACGTGGCC	0.632		NaN											0	0	0	0.146539	0	15	47									
GNPNAT1	64841	broad.mit.edu	37	14	53251332	53251332	+	Missense_Mutation	SNP	G	G	C			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr14:53251332G>C	uc001xab.2	-	2	292	c.37C>G	c.(37-39)CTA>GTA	p.L13V		NM_198066	NP_932332	Q96EK6	GNA1_HUMAN	glucosamine-phosphate N-acetyltransferase 1	13					dolichol-linked oligosaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine|UDP-N-acetylglucosamine biosynthetic process	cytosol|endosome membrane|Golgi membrane	glucosamine 6-phosphate N-acetyltransferase activity				0	Breast(41;0.176)					TCTTTGAGTAGACTTGGGTCA	0.363		NaN											0	0	0	0.038395	0	13	18									
SMOC1	64093	broad.mit.edu	37	14	70418941	70418941	+	Silent	SNP	C	C	A			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr14:70418941C>A	uc001xls.1	+	2	439	c.186C>A	c.(184-186)TCC>TCA	p.S62S	SMOC1_uc001xlt.1_Silent_p.S62S	NM_022137	NP_071420	Q9H4F8	SMOC1_HUMAN	secreted modular calcium-binding protein 1	62	Kazal-like.				cell differentiation|eye development|limb development|regulation of osteoblast differentiation|signal transduction	basement membrane	calcium ion binding			upper_aerodigestive_tract(1)|pancreas(1)	2				all cancers(60;0.00417)|BRCA - Breast invasive adenocarcinoma(234;0.0119)|OV - Ovarian serous cystadenocarcinoma(108;0.028)		ATGGCAGGTCCTACGAGTCCA	0.562		NaN											1	0	9.62906e-15	0.086207	1.07754e-14	32	75									
ADAM20	8748	broad.mit.edu	37	14	70991613	70991613	+	Silent	SNP	G	G	A			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr14:70991613G>A	uc001xme.2	-	2	257	c.12C>T	c.(10-12)CTC>CTT	p.L4L		NM_003814	NP_003805	O43506	ADA20_HUMAN	ADAM metallopeptidase domain 20 preproprotein	Error:Variant_position_missing_in_O43506_after_alignment					proteolysis|single fertilization	integral to membrane	metalloendopeptidase activity|zinc ion binding			skin(1)	1			KIRC - Kidney renal clear cell carcinoma(12;0.133)|Kidney(31;0.188)	all cancers(60;0.00294)|BRCA - Breast invasive adenocarcinoma(234;0.00668)|OV - Ovarian serous cystadenocarcinoma(108;0.0344)		TGTCCTGGTGGAGCTGGACCA	0.522		NaN											0	0	0	0.139131	0	67	46									
MTA1	9112	broad.mit.edu	37	14	105936438	105936438	+	Missense_Mutation	SNP	G	G	C			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr14:105936438G>C	uc001yqx.2	+	21	2221	c.2034G>C	c.(2032-2034)AAG>AAC	p.K678N	MTA1_uc001yqy.2_RNA|MTA1_uc001yrb.2_Missense_Mutation_p.K443N|CRIP2_uc010tyr.1_5'Flank|CRIP2_uc001yrc.2_5'Flank	NM_004689	NP_004680	Q13330	MTA1_HUMAN	metastasis associated protein	678					signal transduction	cytoplasm|nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|central_nervous_system(1)	2		all_cancers(154;0.0293)|all_epithelial(191;0.128)|Melanoma(154;0.155)	OV - Ovarian serous cystadenocarcinoma(23;0.00897)|Epithelial(46;0.026)	Epithelial(152;0.19)		CGGAAACCAAGCGTGCTGCCC	0.716		NaN											0	0	0	0.116897	0	21	48									
HERC2	8924	broad.mit.edu	37	15	28458889	28458889	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr15:28458889G>A	uc001zbj.2	-	42	6891	c.6785C>T	c.(6784-6786)CCA>CTA	p.P2262L		NM_004667	NP_004658	O95714	HERC2_HUMAN	hect domain and RLD 2	2262					DNA repair|intracellular protein transport|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	guanyl-nucleotide exchange factor activity|heme binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(4)|lung(4)|skin(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	13		all_lung(180;1.3e-11)|Breast(32;0.000194)|Colorectal(260;0.227)		all cancers(64;3.93e-09)|Epithelial(43;9.99e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0271)|GBM - Glioblastoma multiforme(186;0.0497)|Lung(196;0.199)		TTCACCTACTGGTTTCAGCTG	0.478		NaN											0	0	0	0.146539	0	14	22									
MYO5A	4644	broad.mit.edu	37	15	52632551	52632551	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr15:52632551C>T	uc002aby.2	-	32	4325	c.4081G>A	c.(4081-4083)GAG>AAG	p.E1361K	MYO5A_uc002abx.3_Missense_Mutation_p.E1334K|MYO5A_uc010ugd.1_Missense_Mutation_p.E83K|MYO5A_uc002abz.1_RNA|MYO5A_uc002aca.1_Missense_Mutation_p.E113K|MYO5A_uc002acb.1_Missense_Mutation_p.E86K|MYO5A_uc002acc.1_Missense_Mutation_p.E110K	NM_000259	NP_000250	Q9Y4I1	MYO5A_HUMAN	myosin VA isoform 1	1361	Potential.				actin filament-based movement|transport	cytoplasm|growth cone|myosin complex|ruffle	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(3)|central_nervous_system(1)	4				all cancers(107;0.0085)|Colorectal(133;0.077)|READ - Rectum adenocarcinoma(133;0.196)		GCCTCATTCTCATGGCTCCTC	0.632		NaN											0	0	0	0.139131	0	55	411									
CACNG3	10368	broad.mit.edu	37	16	24268126	24268126	+	Silent	SNP	C	C	T			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr16:24268126C>T	uc002dmf.2	+	1	1251	c.51C>T	c.(49-51)GCC>GCT	p.A17A		NM_006539	NP_006530	O60359	CCG3_HUMAN	voltage-dependent calcium channel gamma-3	17	Helical; (Potential).				regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|endocytic vesicle membrane|voltage-gated calcium channel complex	voltage-gated calcium channel activity				0				GBM - Glioblastoma multiforme(48;0.0809)		CTGTAGGAGCCTTTGCCGCTT	0.473		NaN											0	0	0	0.043863	0	17	801									
SEZ6L2	26470	broad.mit.edu	37	16	29883848	29883848	+	Splice_Site	SNP	C	C	G			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr16:29883848C>G	uc002duq.3	-	15	2729	c.2489_splice	c.e15-1	p.V830_splice	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|SEZ6L2_uc002dup.3_Splice_Site_p.V773_splice|SEZ6L2_uc002dur.3_Splice_Site_p.V760_splice|SEZ6L2_uc002dus.3_Splice_Site_p.V729_splice|SEZ6L2_uc010vec.1_Splice_Site_p.V843_splice|SEZ6L2_uc010ved.1_Splice_Site_p.V799_splice	NM_201575	NP_963869	Q6UXD5	SE6L2_HUMAN	seizure related 6 homolog (mouse)-like 2 isoform							endoplasmic reticulum membrane|integral to membrane|plasma membrane				ovary(1)|skin(1)	2						GTCTGGGTCACTACAGGAGGA	0.657		NaN											0	0	0	0.062417	0	15	64									
DOC2A	8448	broad.mit.edu	37	16	30018508	30018508	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr16:30018508C>T	uc002dvm.2	-	6	740	c.640G>A	c.(640-642)GAG>AAG	p.E214K	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|DOC2A_uc002dvl.2_Missense_Mutation_p.E214K|DOC2A_uc002dvn.2_Missense_Mutation_p.E214K|DOC2A_uc010vef.1_RNA|DOC2A_uc002dvo.2_Missense_Mutation_p.E214K|DOC2A_uc002dvp.2_Missense_Mutation_p.E214K|DOC2A_uc002dvq.2_Missense_Mutation_p.E214K	NM_003586	NP_003577	Q14183	DOC2A_HUMAN	double C2-like domains, alpha	214					nervous system development|regulation of calcium ion-dependent exocytosis	cell junction|lysosome|synaptic vesicle membrane|synaptosome	calcium-dependent phospholipid binding|protein binding|transporter activity			ovary(2)	2						ACCTGGCGCTCGAGGCAGATG	0.627		NaN											0	0	0	0.09319	0	9	229									
ZNF768	79724	broad.mit.edu	37	16	30536523	30536523	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr16:30536523C>T	uc002dyk.3	-	2	1114	c.938G>A	c.(937-939)GGC>GAC	p.G313D	ZNF768_uc010vex.1_Missense_Mutation_p.G282D|uc002dyl.1_5'Flank|ZNF768_uc010vew.1_Missense_Mutation_p.G282D	NM_024671	NP_078947	Q9H5H4	ZN768_HUMAN	zinc finger protein 768	313					regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	DNA-directed RNA polymerase II, core complex	DNA binding|zinc ion binding				0						GGGCCGCTCGCCAGTGTGGGT	0.607		NaN											0	0	0	0.038395	0	14	49									
ZNF768	79724	broad.mit.edu	37	16	30537018	30537018	+	Missense_Mutation	SNP	C	C	A			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr16:30537018C>A	uc002dyk.3	-	2	619	c.443G>T	c.(442-444)AGA>ATA	p.R148I	ZNF768_uc010vex.1_Missense_Mutation_p.R117I|uc002dyl.1_5'Flank|ZNF768_uc010vew.1_Missense_Mutation_p.R117I	NM_024671	NP_078947	Q9H5H4	ZN768_HUMAN	zinc finger protein 768	148					regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	DNA-directed RNA polymerase II, core complex	DNA binding|zinc ion binding				0						GGATTCATATCTAGAGCTCTC	0.527		NaN											1	0	8.10497e-08	0.055883	8.72367e-08	22	77									
ZNF768	79724	broad.mit.edu	37	16	30537349	30537349	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr16:30537349C>T	uc002dyk.3	-	2	288	c.112G>A	c.(112-114)GAG>AAG	p.E38K	ZNF768_uc010vex.1_Missense_Mutation_p.E7K|uc002dyl.1_5'Flank|ZNF768_uc010vew.1_Missense_Mutation_p.E7K	NM_024671	NP_078947	Q9H5H4	ZN768_HUMAN	zinc finger protein 768	38	Poly-Glu.				regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	DNA-directed RNA polymerase II, core complex	DNA binding|zinc ion binding				0						gaaatttcctctTCCTCATTC	0.408		NaN											0	0	0	0.080422	0	29	139									
ZNF747	65988	broad.mit.edu	37	16	30545884	30545884	+	Silent	SNP	G	G	A			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr16:30545884G>A	uc002dyn.2	-	1	311	c.117C>T	c.(115-117)TTC>TTT	p.F39F	ZNF768_uc010vex.1_5'UTR|ZNF747_uc002dyo.1_Silent_p.F39F|ZNF747_uc010vey.1_Silent_p.F39F|uc002dyp.1_5'Flank	NM_023931	NP_076420	Q9BV97	ZN747_HUMAN	zinc finger protein 747	39	KRAB.				regulation of transcription, DNA-dependent	intracellular	nucleic acid binding				0						CCACGTCGGCGAAGCTCACGG	0.731		NaN											0	0	0	0.047766	0	5	10									
ABCC11	85320	broad.mit.edu	37	16	48234386	48234387	+	Nonsense_Mutation	DNP	CC	CC	TA			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr16:48234386_48234387CC>TA	uc002eff.1	-	14	2232_2233	c.1882_1883GG>TA	c.(1882-1884)GGA>TAA	p.G628*	ABCC11_uc002efg.1_Nonsense_Mutation_p.G628*|ABCC11_uc002efh.1_Nonsense_Mutation_p.G628*|ABCC11_uc010vgk.1_RNA	NM_033151	NP_149163	Q96J66	ABCCB_HUMAN	ATP-binding cassette, sub-family C, member 11	628	ABC transporter 1.|Cytoplasmic (Potential).					integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(3)|skin(2)|central_nervous_system(1)	6		all_cancers(37;0.127)|all_lung(18;0.132)|Breast(268;0.166)				GCCCCGCTCTCCAATCTGCAGA	0.594		NaN							Cerumen_Type				0	0	0	0.115264	0	6	47									
CDH13	1012	broad.mit.edu	37	16	83711918	83711918	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr16:83711918G>A	uc002fgx.2	+	10	1510	c.1390G>A	c.(1390-1392)GTC>ATC	p.V464I	CDH13_uc010vns.1_Missense_Mutation_p.V511I|CDH13_uc010vnt.1_Missense_Mutation_p.V210I|CDH13_uc010vnu.1_Missense_Mutation_p.V425I	NM_001257	NP_001248	P55290	CAD13_HUMAN	cadherin 13 preproprotein	464	Cadherin 3.				adherens junction organization|calcium-dependent cell-cell adhesion|cell junction assembly|endothelial cell migration|homophilic cell adhesion|keratinocyte proliferation|lamellipodium assembly|localization within membrane|low-density lipoprotein particle mediated signaling|negative regulation of cell adhesion|negative regulation of cell proliferation|positive regulation of calcium-mediated signaling|positive regulation of cell migration|positive regulation of cell-matrix adhesion|positive regulation of endothelial cell proliferation|positive regulation of positive chemotaxis|positive regulation of smooth muscle cell proliferation|positive regulation of survival gene product expression|Rac protein signal transduction|regulation of endocytosis|regulation of epidermal growth factor receptor signaling pathway|Rho protein signal transduction|sprouting angiogenesis	anchored to membrane|caveola|extracellular space|integral to membrane|neuron projection	adiponectin binding|cadherin binding|calcium ion binding|low-density lipoprotein particle binding			large_intestine(1)	1		all_cancers(2;1.34e-11)|all_epithelial(2;4.3e-09)		COAD - Colon adenocarcinoma(5;0.0268)		CACAGCCACCGTCCACATCAC	0.577		NaN											0	0	0	0.132662	0	13	69									
SGSM2	9905	broad.mit.edu	37	17	2279473	2279473	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr17:2279473G>A	uc002fun.3	+	18	2567	c.2392G>A	c.(2392-2394)GAC>AAC	p.D798N	SGSM2_uc002fum.3_Missense_Mutation_p.D843N|SGSM2_uc010vqw.1_Missense_Mutation_p.D798N|SGSM2_uc002fup.1_5'UTR|SGSM2_uc002fuq.2_5'Flank	NM_001098509	NP_001091979	O43147	SGSM2_HUMAN	RUN and TBC1 domain containing 1 isoform 2	798	Rab-GAP TBC.					intracellular	Rab GTPase activator activity				0				Colorectal(2;5.15e-05)|READ - Rectum adenocarcinoma(2;0.000115)		GCACCGCATAGACAAGGATGT	0.607		NaN											0	0	0	0.043863	0	15	76									
PLD2	5338	broad.mit.edu	37	17	4718857	4718857	+	Silent	SNP	G	G	A			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr17:4718857G>A	uc002fzc.2	+	13	1361	c.1260G>A	c.(1258-1260)CTG>CTA	p.L420L	PLD2_uc010vsj.1_Silent_p.L277L|PLD2_uc002fzd.2_Silent_p.L420L	NM_002663	NP_002654	O14939	PLD2_HUMAN	phospholipase D2	420					cell communication|cytoskeleton organization|small GTPase mediated signal transduction		NAPE-specific phospholipase D activity|phosphatidylinositol binding|phospholipase D activity			breast(2)|upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	5					Choline(DB00122)	AGAGGGCGCTGATGCTGCTGC	0.577		NaN									OREG0024105	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.139131	0	47	165									
RPAIN	84268	broad.mit.edu	37	17	5331461	5331461	+	Missense_Mutation	SNP	G	G	T			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr17:5331461G>T	uc002gbq.2	+	6	1130	c.560G>T	c.(559-561)TGT>TTT	p.C187F	RPAIN_uc010vsz.1_Missense_Mutation_p.C187F|RPAIN_uc002gbp.1_Missense_Mutation_p.C203F|RPAIN_uc010vta.1_3'UTR|RPAIN_uc010vtb.1_Intron|RPAIN_uc002gbs.2_Missense_Mutation_p.C203F|RPAIN_uc002gbt.2_Intron|RPAIN_uc002gbu.2_Intron|RPAIN_uc002gbv.2_RNA|RPAIN_uc002gbr.2_RNA|RPAIN_uc002gbw.2_Intron|RPAIN_uc002gbx.1_5'Flank	NM_001033002	NP_001028174	Q86UA6	RIP_HUMAN	RPA interacting protein isoform b	187	RIP-type.				DNA recombination|DNA repair|DNA-dependent DNA replication|protein import into nucleus|response to UV	cytoplasm|cytoplasm|nucleolus|PML body|PML body	metal ion binding|protein complex binding				0						AGTGCACATTGTCCCCACACA	0.463		NaN											1	0	6.3237e-29	0.139131	7.24912e-29	48	53									
TP53	7157	broad.mit.edu	37	17	7578454	7578454	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr17:7578454G>A	uc002gim.2	-	5	670	c.476C>T	c.(475-477)GCC>GTC	p.A159V	TP53_uc002gig.1_Missense_Mutation_p.A159V|TP53_uc002gih.2_Missense_Mutation_p.A159V|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.A27V|TP53_uc010cng.1_Missense_Mutation_p.A27V|TP53_uc002gii.1_Missense_Mutation_p.A27V|TP53_uc010cnh.1_Missense_Mutation_p.A159V|TP53_uc010cni.1_Missense_Mutation_p.A159V|TP53_uc002gij.2_Missense_Mutation_p.A159V|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.A66V|TP53_uc002gio.2_Missense_Mutation_p.A27V|TP53_uc010vug.1_Missense_Mutation_p.A120V	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	159	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		A -> G (in sporadic cancers; somatic mutation).|A -> T (in sporadic cancers; somatic mutation).|A -> V (in sporadic cancers; somatic mutation).|A -> P (in sporadic cancers; somatic mutation).|A -> D (in sporadic cancers; somatic mutation).|A -> S (in sporadic cancers; somatic mutation).|A -> F (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.A159V(30)|p.A159P(13)|p.A159A(8)|p.A159T(7)|p.A159D(7)|p.0?(7)|p.A159fs*11(5)|p.A159S(4)|p.R158_A159insX(4)|p.R158_A159delRA(2)|p.R156_I162delRVRAMAI(2)|p.V157fs*9(2)|p.A159fs*21(2)|p.V157_C176del20(1)|p.R156_A161delRVRAMA(1)|p.P151_V173del23(1)|p.R156fs*18(1)|p.R156_A161del(1)|p.R158_A159insXX(1)|p.V157_M160delVRAM(1)|p.S149fs*72(1)|p.T155_A161delTRVRAMA(1)|p.R156fs*20(1)|p.V157_I162delVRAMAI(1)|p.A159_Q167delAMAIYKQSQ(1)|p.V157fs*21(1)|p.R158fs*8(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GATGGCCATGGCGCGGACGCG	0.627		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			0	0	0	0.139131	0	48	8									
FLII	2314	broad.mit.edu	37	17	18155374	18155374	+	Silent	SNP	C	C	T	rs145214604		TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr17:18155374C>T	uc002gsr.1	-	11	1236	c.1185G>A	c.(1183-1185)TCG>TCA	p.S395S	FLII_uc002gsq.1_Silent_p.S267S|FLII_uc010cpy.1_Silent_p.S384S|FLII_uc010vxn.1_Silent_p.S364S|FLII_uc010vxo.1_Silent_p.S341S|FLII_uc002gss.1_Silent_p.S395S	NM_002018	NP_002009	Q13045	FLII_HUMAN	flightless I homolog	395	Interaction with LRRFIP1 and LRRFIP2.				multicellular organismal development|muscle contraction|regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|nucleus	actin binding			central_nervous_system(1)|skin(1)	2	all_neural(463;0.228)					GGTTCTGCAGCGAGAAGTCGA	0.652		NaN											0	0	0	0.139131	0	43	43									
SLFN13	146857	broad.mit.edu	37	17	33769022	33769022	+	Silent	SNP	C	C	T			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr17:33769022C>T	uc002hjk.1	-	3	1812	c.1482G>A	c.(1480-1482)TTG>TTA	p.L494L	SLFN13_uc010wch.1_Silent_p.L494L|SLFN13_uc002hjl.2_Silent_p.L494L|SLFN13_uc010ctt.2_Silent_p.L176L|SLFN13_uc002hjm.2_Silent_p.L163L	NM_144682	NP_653283	Q68D06	SLN13_HUMAN	schlafen family member 13	494						intracellular	ATP binding			ovary(1)|breast(1)	2				UCEC - Uterine corpus endometrioid carcinoma (308;0.0185)		GCTTCTGCTTCAAAGTAAAGG	0.582		NaN											0	0	0	0.069234	0	5	67									
ITGA3	3675	broad.mit.edu	37	17	48155574	48155574	+	Silent	SNP	G	G	A			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr17:48155574G>A	uc010dbl.2	+	18	2687	c.2223G>A	c.(2221-2223)TCG>TCA	p.S741S	ITGA3_uc010dbm.2_Silent_p.S741S	NM_002204	NP_002195	P26006	ITA3_HUMAN	integrin alpha 3 isoform a precursor	741	Extracellular (Potential).				blood coagulation|cell-matrix adhesion|integrin-mediated signaling pathway|leukocyte migration	cell surface|integrin complex	protein binding|receptor activity			ovary(2)|pancreas(1)	3						TCCCAAGGTCGAGTCACCAGG	0.572		NaN											0	0	0	0.021553	0	5	87									
TEX2	55852	broad.mit.edu	37	17	62230483	62230483	+	Missense_Mutation	SNP	T	T	G			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr17:62230483T>G	uc002jec.2	-	10	3135	c.2962A>C	c.(2962-2964)ATG>CTG	p.M988L	TEX2_uc002jed.2_Missense_Mutation_p.M995L|TEX2_uc002jee.2_Missense_Mutation_p.M988L	NM_018469	NP_060939	Q8IWB9	TEX2_HUMAN	testis expressed sequence 2	988					signal transduction|sphingolipid metabolic process	integral to membrane				ovary(1)	1			BRCA - Breast invasive adenocarcinoma(8;1.33e-10)	READ - Rectum adenocarcinoma(1115;0.0689)		ACAAACCTCATAATCTTACTT	0.383		NaN											0	0	0	0.038147	0	6	31									
BPTF	2186	broad.mit.edu	37	17	65941562	65941562	+	Silent	SNP	G	G	A			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr17:65941562G>A	uc002jgf.2	+	21	6799	c.6738G>A	c.(6736-6738)CAG>CAA	p.Q2246Q	BPTF_uc002jge.2_Silent_p.Q2372Q|BPTF_uc002jgg.2_Silent_p.Q46Q|BPTF_uc002jgh.2_5'Flank	NM_182641	NP_872579	Q12830	BPTF_HUMAN	bromodomain PHD finger transcription factor	2372					brain development|chromatin remodeling|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|NURF complex	sequence-specific DNA binding|transcription factor binding|zinc ion binding			ovary(2)|skin(2)	4	all_cancers(12;6e-11)		BRCA - Breast invasive adenocarcinoma(8;7.48e-08)|Colorectal(3;0.0984)|LUSC - Lung squamous cell carcinoma(166;0.24)			TGTCACCCCAGATGCAGGTAC	0.448		NaN											0	0	0	0.064281	0	27	58									
UTS2R	2837	broad.mit.edu	37	17	80333364	80333364	+	Silent	SNP	G	G	A			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr17:80333364G>A	uc010wvl.1	+	1	1164	c.1164G>A	c.(1162-1164)CCG>CCA	p.P388P		NM_018949	NP_061822	Q9UKP6	UR2R_HUMAN	urotensin 2 receptor	388	Cytoplasmic (Potential).					integral to membrane|plasma membrane				breast(1)	1	Breast(20;0.00106)|all_neural(118;0.0804)		OV - Ovarian serous cystadenocarcinoma(97;0.00928)|BRCA - Breast invasive adenocarcinoma(99;0.0833)			CCAGGGCCCCGGCGTGAGCAC	0.761		NaN											0	0	0	0.021553	0	5	8									
RAB12	201475	broad.mit.edu	37	18	8624998	8624998	+	Splice_Site	SNP	T	T	C			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr18:8624998T>C	uc002knp.2	+	2	570	c.287_splice	c.e2+2	p.W96_splice		NM_001025300	NP_001020471	Q6IQ22	RAB12_HUMAN	RAB12, member RAS oncogene family						protein transport|small GTPase mediated signal transduction	Golgi membrane	GTP binding				0						ACAGATCTGGTAAGTGGGAGA	0.358		NaN											0	0	0	0.139131	0	45	96									
CD209	30835	broad.mit.edu	37	19	7810561	7810561	+	Silent	SNP	G	G	A			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr19:7810561G>A	uc002mht.2	-	4	658	c.591C>T	c.(589-591)ACC>ACT	p.T197T	CD209_uc010xju.1_Intron|CD209_uc010dvp.2_Silent_p.T173T|CD209_uc002mhr.2_Silent_p.T173T|CD209_uc002mhs.2_Silent_p.T173T|CD209_uc002mhu.2_Intron|CD209_uc010dvq.2_Silent_p.T197T|CD209_uc002mhq.2_Silent_p.T197T|CD209_uc002mhv.2_Silent_p.T173T|CD209_uc002mhx.2_Silent_p.T153T|CD209_uc002mhw.2_Intron|CD209_uc010dvr.2_Intron	NM_021155	NP_066978	Q9NNX6	CD209_HUMAN	CD209 molecule isoform 1	197	Extracellular (Probable).|5.|7 X approximate tandem repeats.				cell-cell recognition|endocytosis|heterophilic cell-cell adhesion|innate immune response|intracellular signal transduction|intracellular virion transport|leukocyte cell-cell adhesion|peptide antigen transport|viral genome replication|virion attachment to host cell surface receptor	cytoplasm|extracellular region|integral to membrane|plasma membrane	mannose binding|metal ion binding|peptide antigen binding|receptor activity|virion binding			skin(1)	1						CCTTCAGCCGGGTCAGCTCCT	0.567		NaN											0	0	0	0.02938	0	5	174									
CD209	30835	broad.mit.edu	37	19	7810767	7810767	+	Missense_Mutation	SNP	G	G	A	rs146082308		TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr19:7810767G>A	uc002mht.2	-	4	452	c.385C>T	c.(385-387)CGG>TGG	p.R129W	CD209_uc010xju.1_Intron|CD209_uc010dvp.2_Missense_Mutation_p.R105W|CD209_uc002mhr.2_Missense_Mutation_p.R105W|CD209_uc002mhs.2_Missense_Mutation_p.R105W|CD209_uc002mhu.2_Missense_Mutation_p.R129W|CD209_uc010dvq.2_Missense_Mutation_p.R129W|CD209_uc002mhq.2_Missense_Mutation_p.R129W|CD209_uc002mhv.2_Missense_Mutation_p.R105W|CD209_uc002mhx.2_Missense_Mutation_p.R85W|CD209_uc002mhw.2_Missense_Mutation_p.R85W|CD209_uc010dvr.2_Intron	NM_021155	NP_066978	Q9NNX6	CD209_HUMAN	CD209 molecule isoform 1	129	Extracellular (Probable).|2.|7 X approximate tandem repeats.				cell-cell recognition|endocytosis|heterophilic cell-cell adhesion|innate immune response|intracellular signal transduction|intracellular virion transport|leukocyte cell-cell adhesion|peptide antigen transport|viral genome replication|virion attachment to host cell surface receptor	cytoplasm|extracellular region|integral to membrane|plasma membrane	mannose binding|metal ion binding|peptide antigen binding|receptor activity|virion binding			skin(1)	1						GCCTTCAGCCGGGTCAGCTCC	0.567		NaN											0	0	0	0.02938	0	5	292									
ICAM5	7087	broad.mit.edu	37	19	10402342	10402342	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr19:10402342G>A	uc002mnu.3	+	3	595	c.530G>A	c.(529-531)CGG>CAG	p.R177Q	ICAM5_uc002mnv.3_Missense_Mutation_p.R52Q	NM_003259	NP_003250	Q9UMF0	ICAM5_HUMAN	intercellular adhesion molecule 5 precursor	177	Extracellular (Potential).|Ig-like C2-type 2.				cell-cell adhesion	integral to plasma membrane				breast(3)	3			OV - Ovarian serous cystadenocarcinoma(20;2.64e-09)|Epithelial(33;4.31e-06)|all cancers(31;9.75e-06)			CCCCGAGCGCGGGGCGCGGTG	0.736		NaN											0	0	0	0.080935	0	7	23									
ZNF878	729747	broad.mit.edu	37	19	12155673	12155673	+	Missense_Mutation	SNP	A	A	C			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr19:12155673A>C	uc002mta.1	-	5	684	c.684T>G	c.(682-684)AGT>AGG	p.S228R		NM_001080404	NP_001073873	C9JN71	ZN878_HUMAN	zinc finger protein 878	181	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding				0						AACTGGGAAAACTGAATGCTT	0.403		NaN											0	0	0	0.021553	0	4	158									
ZNF799	90576	broad.mit.edu	37	19	12501446	12501446	+	Missense_Mutation	SNP	T	T	C			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr19:12501446T>C	uc010dyt.2	-	4	1916	c.1766A>G	c.(1765-1767)GAA>GGA	p.E589G	ZNF799_uc002mts.3_Intron	NM_001080821	NP_001074290	Q96GE5	ZN799_HUMAN	zinc finger protein 799	589	C2H2-type 17.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(3)|ovary(2)|skin(1)	6						TTCCTTACATTCATACGGGTT	0.413		NaN											0	0	0	0.115264	0	3	41									
KLHL26	55295	broad.mit.edu	37	19	18778894	18778894	+	Silent	SNP	G	G	A	rs150852328	byFrequency	TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr19:18778894G>A	uc002njz.1	+	3	714	c.687G>A	c.(685-687)GCG>GCA	p.A229A		NM_018316	NP_060786	Q53HC5	KLH26_HUMAN	kelch-like 26	229	BACK.									ovary(1)	1						TGTTCCGCGCGGCCGTCCGCT	0.582		NaN											0	0	0	0.11911	0	14	22									
ZNF208	7757	broad.mit.edu	37	19	22155282	22155282	+	Missense_Mutation	SNP	T	T	C			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr19:22155282T>C	uc002nqp.2	-	5	2403	c.2254A>G	c.(2254-2256)AAG>GAG	p.K752E	ZNF208_uc002nqo.1_Intron	NM_007153	NP_009084			zinc finger protein 208											ovary(5)|skin(2)	7		all_lung(12;0.0961)|Lung NSC(12;0.103)				TGAATTACCTTATGTTTAGTA	0.373		NaN											0	0	0	0.115264	0	3	58									
ZNF91	7644	broad.mit.edu	37	19	23544867	23544867	+	Missense_Mutation	SNP	T	T	C			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr19:23544867T>C	uc002nre.2	-	4	1027	c.914A>G	c.(913-915)CAT>CGT	p.H305R	ZNF91_uc010xrj.1_Missense_Mutation_p.H273R	NM_003430	NP_003421	Q05481	ZNF91_HUMAN	zinc finger protein 91	305	C2H2-type 6.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		all_lung(12;0.0349)|Lung NSC(12;0.0538)|all_epithelial(12;0.0611)				GGTTGAAGAATGGCTAAAAGC	0.413		NaN											0	0	0	0.021553	0	6	151									
SLC8A2	6543	broad.mit.edu	37	19	47935695	47935695	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr19:47935695C>G	uc002pgx.2	-	9	2396	c.2118G>C	c.(2116-2118)GAG>GAC	p.E706D	SLC8A2_uc010xyq.1_Missense_Mutation_p.E462D|SLC8A2_uc010xyr.1_Missense_Mutation_p.E169D|SLC8A2_uc010ele.2_Missense_Mutation_p.E706D	NM_015063	NP_055878	Q9UPR5	NAC2_HUMAN	solute carrier family 8 member 2 precursor	706	Cytoplasmic (Potential).				cell communication|platelet activation	integral to membrane|plasma membrane	calcium:sodium antiporter activity|calmodulin binding			skin(3)|ovary(1)	4		all_cancers(25;3.05e-07)|all_lung(116;4.19e-06)|Lung NSC(112;7.16e-06)|all_epithelial(76;7.65e-06)|all_neural(266;0.0652)|Ovarian(192;0.086)|Breast(70;0.173)		OV - Ovarian serous cystadenocarcinoma(262;0.000501)|all cancers(93;0.00058)|Epithelial(262;0.0181)|GBM - Glioblastoma multiforme(486;0.0457)		CCTCCTCCTCCTCGTCCCCTG	0.602		NaN											0	0	0	0.021553	0	5	144									
CPT1C	126129	broad.mit.edu	37	19	50216744	50216744	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr19:50216744G>A	uc002ppj.2	+	19	2499	c.2294G>A	c.(2293-2295)GGA>GAA	p.G765E	CPT1C_uc002ppk.2_Missense_Mutation_p.G754E|CPT1C_uc010eng.2_Missense_Mutation_p.G765E|CPT1C_uc010enh.2_Missense_Mutation_p.G765E|CPT1C_uc010eni.1_Missense_Mutation_p.G333E	NM_152359	NP_689572	Q8TCG5	CPT1C_HUMAN	carnitine palmitoyltransferase 1C isoform 2	765	Cytoplasmic (Potential).				fatty acid metabolic process	integral to membrane|mitochondrial outer membrane	carnitine O-palmitoyltransferase activity			ovary(1)|central_nervous_system(1)|pancreas(1)	3		all_lung(116;1.05e-05)|Lung NSC(112;3.77e-05)|all_neural(266;0.107)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.0011)|GBM - Glioblastoma multiforme(134;0.00786)		TTCCAGGCGGGACAGCATTTT	0.542		NaN											0	0	0	0.125774	0	23	101									
ZNF836	162962	broad.mit.edu	37	19	52659075	52659075	+	Missense_Mutation	SNP	C	C	A			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr19:52659075C>A	uc010ydi.1	-	5	2235	c.1861G>T	c.(1861-1863)GAC>TAC	p.D621Y	ZNF836_uc010ydj.1_Missense_Mutation_p.D621Y	NM_001102657	NP_001096127	Q6ZNA1	ZN836_HUMAN	zinc finger protein 836	621	C2H2-type 15.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						TTTCCACTGTCATTGAAGACC	0.423		NaN											1	0	3.59834e-05	0.021553	3.84368e-05	4	148									
ZNF83	55769	broad.mit.edu	37	19	53116804	53116804	+	Silent	SNP	G	G	A			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr19:53116804G>A	uc002pzu.3	-	2	2258	c.1014C>T	c.(1012-1014)ATC>ATT	p.I338I	ZNF83_uc002pzv.3_Silent_p.I338I|ZNF83_uc010eps.2_Silent_p.I310I|ZNF83_uc010ept.2_Silent_p.I338I|ZNF83_uc010epu.2_Silent_p.I338I|ZNF83_uc010epv.2_Silent_p.I338I|ZNF83_uc010epw.2_Silent_p.I338I|ZNF83_uc010epx.2_Silent_p.I310I|ZNF83_uc010epy.2_Silent_p.I338I|ZNF83_uc010epz.2_Silent_p.I310I	NM_018300	NP_060770	P51522	ZNF83_HUMAN	zinc finger protein 83 isoform a	338	C2H2-type 9.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(262;0.00841)|GBM - Glioblastoma multiforme(134;0.0244)		CTCCAGTGTGGATTCTCCAGT	0.413		NaN											0	0	0	0.021553	0	5	205									
ZNF347	84671	broad.mit.edu	37	19	53644380	53644380	+	Silent	SNP	T	T	C			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr19:53644380T>C	uc002qbb.1	-	5	1770	c.1701A>G	c.(1699-1701)AAA>AAG	p.K567K	ZNF347_uc010eql.1_Silent_p.K568K|ZNF347_uc002qbc.1_Silent_p.K568K	NM_032584	NP_115973	Q96SE7	ZN347_HUMAN	zinc finger protein 347	567					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				GBM - Glioblastoma multiforme(134;0.0179)		ATTTGTAAGGTTTTTCTCCAG	0.413		NaN											0	0	0	0.02938	0	6	250									
ZNF761	388561	broad.mit.edu	37	19	53958826	53958826	+	Silent	SNP	G	G	A			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr19:53958826G>A	uc010eqp.2	+	7	1523	c.1065G>A	c.(1063-1065)AAG>AAA	p.K355K	ZNF761_uc010ydy.1_Silent_p.K301K|ZNF761_uc002qbt.1_Silent_p.K301K	NM_001008401	NP_001008401	Q86XN6	ZN761_HUMAN	zinc finger protein 761	355	C2H2-type 6.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1				GBM - Glioblastoma multiforme(134;0.00786)		AACCTTACAAGTGTAATGAGT	0.418		NaN											0	0	0	0.038147	0	6	263									
ZNF329	79673	broad.mit.edu	37	19	58639722	58639722	+	Silent	SNP	G	G	A			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr19:58639722G>A	uc002qrn.2	-	4	1386	c.1149C>T	c.(1147-1149)AAC>AAT	p.N383N	ZNF329_uc010euk.1_RNA|ZNF329_uc002qro.1_RNA|ZNF329_uc002qrp.1_RNA	NM_024620	NP_078896	Q86UD4	ZN329_HUMAN	zinc finger protein 329	383	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1		Colorectal(82;5.46e-05)|all_neural(62;0.0182)|Breast(46;0.029)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.017)|Lung(386;0.216)		TGAGGTGAGAGTTTCTGTTGA	0.498		NaN											0	0	0	0.09836	0	35	102									
GPAT2	150763	broad.mit.edu	37	2	96698049	96698049	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr2:96698049C>T	uc002svf.2	-	2	282	c.59G>A	c.(58-60)CGA>CAA	p.R20Q	GPAT2_uc002svg.2_5'UTR|GPAT2_uc010yuh.1_Missense_Mutation_p.R20Q|GPAT2_uc002svh.2_Missense_Mutation_p.R20Q	NM_207328	NP_997211	Q6NUI2	GPAT2_HUMAN	glycerol-3-phosphate acyltransferase 2,	20					glycerol-3-phosphate metabolic process|phospholipid biosynthetic process|triglyceride biosynthetic process	integral to membrane|mitochondrial outer membrane	glycerol-3-phosphate O-acyltransferase activity				0						CATTACCTCTCGGCCACTGGG	0.572		NaN											0	0	0	0.058154	0	6	44									
IL18R1	8809	broad.mit.edu	37	2	103013325	103013325	+	Silent	SNP	G	G	A			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr2:103013325G>A	uc002tbw.3	+	11	1755	c.1605G>A	c.(1603-1605)TTG>TTA	p.L535L	IL18R1_uc010ywc.1_Silent_p.L534L|IL18R1_uc010ywd.1_Silent_p.L379L|IL18R1_uc010fiy.2_Silent_p.L535L	NM_003855	NP_003846	Q13478	IL18R_HUMAN	interleukin 18 receptor 1 precursor	535	Cytoplasmic (Potential).				innate immune response	integral to membrane|plasma membrane	interleukin-1 receptor activity			ovary(2)|pancreas(1)	3						CGGAAGTCTTGCCTGTTCTTT	0.413		NaN											0	0	0	0.080935	0	9	21									
SULT1C4	27233	broad.mit.edu	37	2	108994731	108994731	+	Translation_Start_Site	SNP	C	C	T			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr2:108994731C>T	uc002tea.1	+	1	311	c.-62C>T	c.(-64--60)AACGC>AATGC		SULT1C4_uc002tdz.2_Translation_Start_Site|SULT1C4_uc010ywr.1_RNA|SULT1C4_uc002teb.1_Translation_Start_Site	NM_006588	NP_006579	O75897	ST1C4_HUMAN	sulfotransferase family, cytosolic, 1C, member						3'-phosphoadenosine 5'-phosphosulfate metabolic process|sulfation|xenobiotic metabolic process	cytosol	sulfotransferase activity				0						CTATCCACAACGCAGCCATAT	0.488		NaN											0	0	0	0.02938	0	7	29									
CHD6	84181	broad.mit.edu	37	20	40049547	40049547	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr20:40049547C>G	uc002xka.1	-	31	5906	c.5728G>C	c.(5728-5730)GAT>CAT	p.D1910H		NM_032221	NP_115597	Q8TD26	CHD6_HUMAN	chromodomain helicase DNA binding protein 6	1910					chromatin remodeling|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding			ovary(6)|skin(5)|lung(2)|central_nervous_system(1)	14		Myeloproliferative disorder(115;0.00425)				TTGGTTTCATCTTGGAAGCCT	0.517		NaN											0	0	0	0.125774	0	23	42									
PREX1	57580	broad.mit.edu	37	20	47266680	47266680	+	Missense_Mutation	SNP	G	G	A	rs41283554		TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr20:47266680G>A	uc002xtw.1	-	24	2905	c.2882C>T	c.(2881-2883)CCG>CTG	p.P961L	PREX1_uc002xtv.1_Missense_Mutation_p.P258L	NM_020820	NP_065871	Q8TCU6	PREX1_HUMAN	phosphatidylinositol-3,4,	961					actin filament polymerization|apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|neutrophil activation|small GTPase mediated signal transduction|superoxide metabolic process	cytosol|plasma membrane	enzyme binding|phospholipid binding|Rho GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			lung(3)|ovary(2)|pancreas(1)	6			BRCA - Breast invasive adenocarcinoma(12;0.0135)|Colorectal(8;0.198)			GCCACACAGCGGGTGGGGCTC	0.592		NaN											0	0	0	0.124865	0	33	132									
IFNAR2	3455	broad.mit.edu	37	21	34621017	34621017	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr21:34621017C>G	uc002yrd.2	+	6	726	c.398C>G	c.(397-399)TCT>TGT	p.S133C	IFNAR2_uc002yrb.2_Missense_Mutation_p.S133C|IFNAR2_uc002yrc.2_Missense_Mutation_p.S133C|IFNAR2_uc002yre.2_Missense_Mutation_p.S133C|IFNAR2_uc002yrf.2_Missense_Mutation_p.S133C|IFNAR2_uc002yrg.2_Missense_Mutation_p.S2C|IL10RB_uc002yrh.1_5'UTR|IL10RB_uc002yri.1_5'UTR	NM_207585	NP_997468	P48551	INAR2_HUMAN	interferon alpha/beta receptor 2 isoform a	133	Extracellular (Potential).				JAK-STAT cascade|regulation of type I interferon-mediated signaling pathway|response to interferon-alpha|response to virus|type I interferon-mediated signaling pathway	extracellular region|extracellular space|integral to plasma membrane	protein kinase binding|type I interferon binding|type I interferon receptor activity				0					Interferon Alfa-2a, Recombinant(DB00034)|Interferon Alfa-2b, Recombinant(DB00105)|Interferon alfa-n1(DB00011)|Interferon alfa-n3(DB00018)|Interferon alfacon-1(DB00069)|Interferon beta-1b(DB00068)|Peginterferon alfa-2a(DB00008)|Peginterferon alfa-2b(DB00022)	tGCACAGTGTCTTTTGAACCA	0.194		NaN											0	0	0	0.043863	0	17	80									
EDEM1	9695	broad.mit.edu	37	3	5249807	5249807	+	Silent	SNP	C	C	T			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr3:5249807C>T	uc003bqi.2	+	8	1500	c.1368C>T	c.(1366-1368)ATC>ATT	p.I456I	EDEM1_uc011asz.1_Silent_p.I234I|EDEM1_uc003bqh.2_Silent_p.I456I	NM_014674	NP_055489	Q92611	EDEM1_HUMAN	ER degradation enhancer, mannosidase alpha-like	456	Lumenal (Potential).				ER-associated protein catabolic process|post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine|response to unfolded protein	integral to endoplasmic reticulum membrane	calcium ion binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity|misfolded protein binding			ovary(2)|breast(1)	3				Epithelial(13;0.0588)|OV - Ovarian serous cystadenocarcinoma(96;0.0682)		AAGATGCCATCTGCCTTCATG	0.512		NaN											0	0	0	0.139131	0	47	93									
IRAK2	3656	broad.mit.edu	37	3	10264330	10264330	+	Missense_Mutation	SNP	T	T	G			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr3:10264330T>G	uc003bve.1	+	9	1100	c.1024T>G	c.(1024-1026)TTG>GTG	p.L342V		NM_001570	NP_001561	O43187	IRAK2_HUMAN	interleukin-1 receptor-associated kinase 2	342	Protein kinase.				activation of MAPK activity|I-kappaB kinase/NF-kappaB cascade|inflammatory response|innate immune response|interleukin-1-mediated signaling pathway|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of NF-kappaB transcription factor activity|positive regulation of NF-kappaB transcription factor activity|regulation of cytokine-mediated signaling pathway|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cell surface|cytosol|endosome membrane|plasma membrane	ATP binding|NF-kappaB-inducing kinase activity|protein heterodimerization activity|protein homodimerization activity			lung(5)|breast(3)	8						CTCTAATGTCTTGCTGGACCA	0.453		NaN											0	0	0	0.139131	0	64	259									
SEC13	6396	broad.mit.edu	37	3	10342968	10342968	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr3:10342968C>G	uc003bvn.2	-	9	1065	c.946G>C	c.(946-948)GAG>CAG	p.E316Q	SEC13_uc003bvl.2_Missense_Mutation_p.E248Q|SEC13_uc003bvm.2_Missense_Mutation_p.E302Q|SEC13_uc003bvp.2_Missense_Mutation_p.E319Q|SEC13_uc003bvo.2_Missense_Mutation_p.E362Q|SEC13_uc003bvq.1_Intron	NM_183352	NP_899195	P55735	SEC13_HUMAN	SEC13 protein isoform 1	316					COPII vesicle coating|intracellular protein transport|mitotic prometaphase|mRNA transport|post-translational protein modification|protein N-linked glycosylation via asparagine|transmembrane transport	cytosol|endoplasmic reticulum membrane|ER to Golgi transport vesicle membrane|Nup107-160 complex	protein binding			ovary(1)	1						TGCTGGCCCTCTGTCACTGAT	0.607		NaN											0	0	0	0.125774	0	24	236									
ZNF860	344787	broad.mit.edu	37	3	32031962	32031962	+	Missense_Mutation	SNP	A	A	G	rs1808125	by1000genomes	TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr3:32031962A>G	uc011axg.1	+	2	1940	c.1391A>G	c.(1390-1392)CAT>CGT	p.H464R		NM_001137674	NP_001131146	A6NHJ4	ZN860_HUMAN	zinc finger protein 860	464	C2H2-type 9.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						AAGACCTTCCATCACAATTCA	0.418		NaN											0	0	0	0.021553	0	4	110									
PDCD6IP	10015	broad.mit.edu	37	3	33870428	33870428	+	Silent	SNP	G	G	A			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr3:33870428G>A	uc003cfx.2	+	7	956	c.801G>A	c.(799-801)CAG>CAA	p.Q267Q	PDCD6IP_uc003cfy.2_Silent_p.Q272Q|PDCD6IP_uc011axw.1_Silent_p.Q48Q	NM_013374	NP_037506	Q8WUM4	PDC6I_HUMAN	programmed cell death 6 interacting protein	267	Interaction with EIAV p9.|Interaction with CHMP4A, CHMP4B and CHMP4C.|BRO1.				apoptosis|cell cycle|cell division|interspecies interaction between organisms|protein transport	cytosol|melanosome|microtubule organizing center	calcium-dependent protein binding			ovary(1)|skin(1)	2						CAAAACAGCAGAAGAAATTTG	0.388		NaN											0	0	0	0.0333	0	13	43									
COL6A6	131873	broad.mit.edu	37	3	130285707	130285707	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr3:130285707G>A	uc010htl.2	+	4	1475	c.1444G>A	c.(1444-1446)GAC>AAC	p.D482N		NM_001102608	NP_001096078	A6NMZ7	CO6A6_HUMAN	collagen type VI alpha 6 precursor	482	VWFA 3.|Nonhelical region.				axon guidance|cell adhesion	collagen				ovary(6)|central_nervous_system(1)|pancreas(1)	8						TCAGTATGCTGACAGCTGGGA	0.478		NaN											0	0	0	0.059317	0	27	124									
ACPL2	92370	broad.mit.edu	37	3	141011518	141011518	+	Missense_Mutation	SNP	A	A	G			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr3:141011518A>G	uc003etu.2	+	8	1213	c.914A>G	c.(913-915)AAT>AGT	p.N305S	ACPL2_uc003etv.2_Missense_Mutation_p.N305S|ACPL2_uc011bna.1_Missense_Mutation_p.N267S|ACPL2_uc011bnb.1_Missense_Mutation_p.N288S	NM_152282	NP_689495	Q8TE99	ACPL2_HUMAN	acid phosphatase-like 2 precursor	305						extracellular region	acid phosphatase activity			skin(1)	1						TTCTGCCACAATGTCAGCTTT	0.517		NaN											0	0	0	0.105934	0	12	79									
LSG1	55341	broad.mit.edu	37	3	194373664	194373664	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr3:194373664C>T	uc003fui.2	-	8	1282	c.967G>A	c.(967-969)GAA>AAA	p.E323K		NM_018385	NP_060855	Q9H089	LSG1_HUMAN	large subunit GTPase 1	323					nuclear export|protein transport	Cajal body|endoplasmic reticulum	GTP binding|hydrolase activity				0	all_cancers(143;1.68e-08)|Ovarian(172;0.0634)		OV - Ovarian serous cystadenocarcinoma(49;4.34e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;7.55e-06)		CCGTCTTCTTCTGAGCACGTC	0.527		NaN											0	0	0	0.009096	0	4	70									
MUC4	4585	broad.mit.edu	37	3	195512118	195512118	+	Silent	SNP	G	G	A			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr3:195512118G>A	uc011bto.1	-	2	6793	c.6333C>T	c.(6331-6333)ACC>ACT	p.T2111T	MUC4_uc003fvo.2_Intron|MUC4_uc003fvp.2_Intron|MUC4_uc010hzu.1_Intron	NM_018406	NP_060876	Q99102	MUC4_HUMAN	mucin 4 isoform a	886	Ser-rich.				cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity				0	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		CATGAAGAGCGGTGGCGTGAC	0.572		NaN											0	0	0	0.115264	0	3	5									
BMP2K	55589	broad.mit.edu	37	4	79832995	79832995	+	Silent	SNP	C	C	T			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr4:79832995C>T	uc003hlk.2	+	16	3460	c.3294C>T	c.(3292-3294)GTC>GTT	p.V1098V	PAQR3_uc003hlm.2_Intron|PAQR3_uc003hln.2_Intron|uc010ijm.1_5'Flank	NM_198892	NP_942595	Q9NSY1	BMP2K_HUMAN	BMP-2 inducible kinase isoform a	1098						nucleus	ATP binding|protein serine/threonine kinase activity			lung(1)	1						ACAATACTGTCCTGCCAGGGC	0.517		NaN											0	0	0	0.02938	0	5	46									
HNRPDL	9987	broad.mit.edu	37	4	83348369	83348369	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr4:83348369C>T	uc003hmr.2	-	5	1530	c.995G>A	c.(994-996)CGA>CAA	p.R332Q	HNRPDL_uc003hmq.2_RNA|HNRPDL_uc003hms.2_RNA|HNRPDL_uc003hmt.2_Missense_Mutation_p.R332Q	NM_031372	NP_112740	O14979	HNRDL_HUMAN	heterogeneous nuclear ribonucleoprotein D-like	332	Gly-rich.				regulation of transcription, DNA-dependent|RNA processing|transcription, DNA-dependent	cytoplasm|heterogeneous nuclear ribonucleoprotein complex	double-stranded DNA binding|nucleotide binding|poly(A) RNA binding|protein binding|single-stranded DNA binding			skin(1)	1		Hepatocellular(203;0.114)				CGTACCACCTCGTCCACCAGC	0.438		NaN											0	0	0	0.139131	0	66	165									
OTUD4	54726	broad.mit.edu	37	4	146059006	146059006	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr4:146059006G>A	uc003ika.3	-	21	2864	c.2726C>T	c.(2725-2727)ACT>ATT	p.T909I	OTUD4_uc003ijz.3_Missense_Mutation_p.T908I	NM_001102653	NP_001096123	Q01804	OTUD4_HUMAN	OTU domain containing 4 protein isoform 3	973							protein binding			ovary(2)|breast(1)	3	all_hematologic(180;0.151)					AACAGGCACAGTTTCTCTCTC	0.463		NaN											0	0	0	0.09319	0	10	71									
OTUD4	54726	broad.mit.edu	37	4	146059041	146059041	+	Silent	SNP	A	A	G			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr4:146059041A>G	uc003ika.3	-	21	2829	c.2691T>C	c.(2689-2691)CAT>CAC	p.H897H	OTUD4_uc003ijz.3_Silent_p.H896H	NM_001102653	NP_001096123	Q01804	OTUD4_HUMAN	OTU domain containing 4 protein isoform 3	961							protein binding			ovary(2)|breast(1)	3	all_hematologic(180;0.151)					GAGTGGGAGGATGAGCCTTTC	0.478		NaN											0	0	0	0.080935	0	9	86									
HCN1	348980	broad.mit.edu	37	5	45262592	45262592	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr5:45262592C>T	uc003jok.2	-	8	2129	c.2104G>A	c.(2104-2106)GCG>ACG	p.A702T		NM_021072	NP_066550	O60741	HCN1_HUMAN	hyperpolarization activated cyclic	702	Cytoplasmic (Potential).					integral to membrane	cAMP binding|sodium channel activity|voltage-gated potassium channel activity			ovary(1)	1						CTGCAGACCGCGGTGGTGTAG	0.592		NaN											0	0	0	0.0333	0	15	4									
DDX4	54514	broad.mit.edu	37	5	55088541	55088541	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr5:55088541G>A	uc003jqg.3	+	17	1449	c.1375G>A	c.(1375-1377)GAA>AAA	p.E459K	DDX4_uc010ivz.2_Missense_Mutation_p.E439K|DDX4_uc003jqh.3_Missense_Mutation_p.E425K|DDX4_uc003jqj.2_Missense_Mutation_p.E310K	NM_001136034	NP_001129506	Q9NQI0	DDX4_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 4 isoform	459	Helicase ATP-binding.				multicellular organismal development|sperm motility	perinuclear region of cytoplasm|pi-body|piP-body	ATP binding|ATP-dependent helicase activity|nucleic acid binding			ovary(1)|skin(1)	2		Lung NSC(810;6.93e-05)|all_neural(839;0.00409)|Prostate(74;0.0107)|Breast(144;0.0544)|Ovarian(174;0.223)				TTTTGGTCCAGAAATGAAGAA	0.378		NaN											0	0	0	0.062417	0	16	24									
DDX4	54514	broad.mit.edu	37	5	55094390	55094390	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr5:55094390C>G	uc003jqg.3	+	18	1680	c.1606C>G	c.(1606-1608)CGA>GGA	p.R536G	DDX4_uc010ivz.2_Missense_Mutation_p.R516G|DDX4_uc003jqh.3_Missense_Mutation_p.R502G|DDX4_uc003jqj.2_Missense_Mutation_p.R387G	NM_001136034	NP_001129506	Q9NQI0	DDX4_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 4 isoform	536	Helicase C-terminal.				multicellular organismal development|sperm motility	perinuclear region of cytoplasm|pi-body|piP-body	ATP binding|ATP-dependent helicase activity|nucleic acid binding			ovary(1)|skin(1)	2		Lung NSC(810;6.93e-05)|all_neural(839;0.00409)|Prostate(74;0.0107)|Breast(144;0.0544)|Ovarian(174;0.223)				TGAAATTCTGCGAAACATAGG	0.343		NaN											0	0	0	0.105934	0	12	18									
ADAMTS6	11174	broad.mit.edu	37	5	64756014	64756014	+	Missense_Mutation	SNP	G	G	C			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr5:64756014G>C	uc003jtp.2	-	4	1428	c.614C>G	c.(613-615)TCT>TGT	p.S205C	ADAMTS6_uc003jto.2_RNA|ADAMTS6_uc003jtq.2_RNA|ADAMTS6_uc003jtr.1_5'UTR	NM_197941	NP_922932	Q9UKP5	ATS6_HUMAN	ADAM metallopeptidase with thrombospondin type 1	205					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding				0		Lung NSC(167;2.44e-06)|Prostate(74;0.014)|Ovarian(174;0.0549)|Breast(144;0.111)|Colorectal(97;0.235)		Lung(70;0.00942)		CCCACAATGAGAGTGATCATA	0.408		NaN											0	0	0	0.144211	0	24	29									
DMGDH	29958	broad.mit.edu	37	5	78294073	78294073	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr5:78294073C>G	uc003kfs.2	-	16	2439	c.2433G>C	c.(2431-2433)AAG>AAC	p.K811N		NM_013391	NP_037523	Q9UI17	M2GD_HUMAN	dimethylglycine dehydrogenase precursor	811					choline metabolic process|glycine catabolic process	mitochondrial matrix	aminomethyltransferase activity|dimethylglycine dehydrogenase activity|electron carrier activity			ovary(2)|liver(1)|skin(1)	4		all_lung(232;0.000638)|Lung NSC(167;0.00173)|Ovarian(174;0.0262)|Prostate(461;0.192)		OV - Ovarian serous cystadenocarcinoma(54;6.52e-45)|Epithelial(54;5.96e-40)|all cancers(79;3.56e-35)		AAGCCAGACTCTTCTGGATGC	0.473		NaN											0	0	0	0.02938	0	7	11									
TSSK1B	83942	broad.mit.edu	37	5	112769745	112769745	+	Silent	SNP	G	G	A			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr5:112769745G>A	uc003kqm.2	-	1	984	c.792C>T	c.(790-792)GAC>GAT	p.D264D	MCC_uc003kql.3_Intron	NM_032028	NP_114417	Q9BXA7	TSSK1_HUMAN	testis-specific serine kinase 1	264	Protein kinase.				cell differentiation|multicellular organismal development|spermatogenesis		ATP binding|magnesium ion binding|protein serine/threonine kinase activity			ovary(2)|skin(2)|stomach(1)	5		all_cancers(142;0.0138)|all_epithelial(76;0.000445)|Colorectal(10;0.00814)|Prostate(80;0.0115)|Ovarian(225;0.156)		Epithelial(69;4.15e-08)|OV - Ovarian serous cystadenocarcinoma(64;4.49e-08)|all cancers(49;3.2e-06)|COAD - Colon adenocarcinoma(37;0.0371)|Colorectal(14;0.0449)		TGAGGATCTCGTCGATGTGGA	0.617		NaN											0	0	0	0.014758	0	4	32									
PCDHA2	56146	broad.mit.edu	37	5	140175132	140175132	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr5:140175132G>A	uc003lhd.2	+	1	689	c.583G>A	c.(583-585)GTG>ATG	p.V195M	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhc.1_Missense_Mutation_p.V195M|PCDHA2_uc011czy.1_Missense_Mutation_p.V195M	NM_018905	NP_061728	Q9Y5H9	PCDA2_HUMAN	protocadherin alpha 2 isoform 1 precursor	195	Extracellular (Potential).|Cadherin 2.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(4)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TTTGTCTCTCGTGCTGGGGAA	0.463		NaN											0	0	0	0.116897	0	24	34									
PCDHGA9	56107	broad.mit.edu	37	5	140784367	140784367	+	Silent	SNP	C	C	T			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr5:140784367C>T	uc003lkh.1	+	1	1848	c.1848C>T	c.(1846-1848)CTC>CTT	p.L616L	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc011dax.1_Silent_p.L616L	NM_018921	NP_061744	Q9Y5G4	PCDG9_HUMAN	protocadherin gamma subfamily A, 9 isoform 1	616	Cadherin 6.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGCCAGGGCTCTTCTCGGTGG	0.597		NaN											0	0	0	0.076483	0	21	20									
TCOF1	6949	broad.mit.edu	37	5	149755460	149755460	+	Missense_Mutation	SNP	G	G	C			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr5:149755460G>C	uc003lry.2	+	12	1989	c.1881G>C	c.(1879-1881)ATG>ATC	p.M627I	TCOF1_uc003lrw.2_Missense_Mutation_p.M627I|TCOF1_uc011dch.1_Missense_Mutation_p.M627I|TCOF1_uc003lrz.2_Missense_Mutation_p.M627I|TCOF1_uc003lrx.2_Missense_Mutation_p.M550I|TCOF1_uc003lsa.2_Missense_Mutation_p.M550I|TCOF1_uc011dci.1_Missense_Mutation_p.M116I	NM_001135243	NP_001128715	Q13428	TCOF_HUMAN	Treacher Collins-Franceschetti syndrome 1	627					skeletal system development	nucleolus	protein binding|transporter activity			ovary(2)|large_intestine(1)	3		all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			CAGCAGCCATGACTGCAGCTC	0.627		NaN											0	0	0	0.058154	0	7	18									
NHLRC1	378884	broad.mit.edu	37	6	18121856	18121856	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr6:18121856C>G	uc003ncl.1	-	1	996	c.982G>C	c.(982-984)GAT>CAT	p.D328H		NM_198586	NP_940988	Q6VVB1	NHLC1_HUMAN	NHL repeat containing 1	328	NHL 5.				proteasomal ubiquitin-dependent protein catabolic process|protein polyubiquitination	endoplasmic reticulum|nucleus	protein binding|ubiquitin-protein ligase activity|zinc ion binding				0	Ovarian(93;0.016)|Breast(50;0.0245)	all_hematologic(90;0.165)	all cancers(50;0.0451)|Epithelial(50;0.0493)			CCCTGGTGATCAAAGGTCACA	0.483		NaN											0	0	0	0.139131	0	61	76									
NHLRC1	378884	broad.mit.edu	37	6	18122765	18122765	+	Nonsense_Mutation	SNP	C	C	A			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr6:18122765C>A	uc003ncl.1	-	1	87	c.73G>T	c.(73-75)GAG>TAG	p.E25*		NM_198586	NP_940988	Q6VVB1	NHLC1_HUMAN	NHL repeat containing 1	25					proteasomal ubiquitin-dependent protein catabolic process|protein polyubiquitination	endoplasmic reticulum|nucleus	protein binding|ubiquitin-protein ligase activity|zinc ion binding				0	Ovarian(93;0.016)|Breast(50;0.0245)	all_hematologic(90;0.165)	all cancers(50;0.0451)|Epithelial(50;0.0493)			ACCTTGCACTCGAGCAGGCTG	0.711		NaN											1	0	9.39395e-14	0.116897	1.0348e-13	22	40									
NHLRC1	378884	broad.mit.edu	37	6	18122786	18122786	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr6:18122786C>T	uc003ncl.1	-	1	66	c.52G>A	c.(52-54)GAG>AAG	p.E18K		NM_198586	NP_940988	Q6VVB1	NHLC1_HUMAN	NHL repeat containing 1	18					proteasomal ubiquitin-dependent protein catabolic process|protein polyubiquitination	endoplasmic reticulum|nucleus	protein binding|ubiquitin-protein ligase activity|zinc ion binding				0	Ovarian(93;0.016)|Breast(50;0.0245)	all_hematologic(90;0.165)	all cancers(50;0.0451)|Epithelial(50;0.0493)			ATCTCCGCCTCGCGCATGAGC	0.711		NaN											0	0	0	0.083992	0	18	33									
CPVL	54504	broad.mit.edu	37	7	29070210	29070210	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr7:29070210C>G	uc003szv.2	-	12	1422	c.1303G>C	c.(1303-1305)GCG>CCG	p.A435P	CPVL_uc003szw.2_Missense_Mutation_p.A435P|CPVL_uc003szx.2_Missense_Mutation_p.A435P	NM_031311	NP_112601	Q9H3G5	CPVL_HUMAN	serine carboxypeptidase vitellogenic-like	435					proteolysis		protein binding|serine-type carboxypeptidase activity			ovary(2)	2						AAGTCACCCGCTTGCCGGATG	0.478		NaN											0	0	0	0.139131	0	167	185									
NOD1	10392	broad.mit.edu	37	7	30485764	30485764	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr7:30485764C>G	uc003tav.2	-	9	2969	c.2446G>C	c.(2446-2448)GAG>CAG	p.E816Q		NM_006092	NP_006083	Q9Y239	NOD1_HUMAN	nucleotide-binding oligomerization domain	816					activation of MAPK activity|detection of bacterium|induction of apoptosis|inflammatory response|innate immune response|interleukin-8 biosynthetic process|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of dendritic cell antigen processing and presentation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|protein oligomerization|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	basolateral plasma membrane|cytosol	ATP binding|CARD domain binding|caspase activator activity|peptidoglycan binding|protein homodimerization activity			ovary(1)|skin(1)	2						CACCCAACCTCAGAGATTGAT	0.488		NaN											0	0	0	0.074837	0	29	398									
AOAH	313	broad.mit.edu	37	7	36657936	36657936	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr7:36657936C>G	uc003tfh.3	-	10	1119	c.718G>C	c.(718-720)GAT>CAT	p.D240H	AOAH_uc010kxf.2_Missense_Mutation_p.D240H|AOAH_uc011kba.1_Missense_Mutation_p.D208H	NM_001637	NP_001628	P28039	AOAH_HUMAN	acyloxyacyl hydrolase precursor	240					inflammatory response|lipid metabolic process	extracellular region	acyloxyacyl hydrolase activity|lipoprotein lipase activity			skin(1)	1						GGAACTCCATCTTTTGGATCG	0.308		NaN											0	0	0	0.09319	0	10	71									
ZNF92	168374	broad.mit.edu	37	7	64863839	64863840	+	Missense_Mutation	DNP	CC	CC	AT			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr7:64863839_64863840CC>AT	uc003ttz.2	+	4	955_956	c.812_813CC>AT	c.(811-813)ACC>AAT	p.T271N	ZNF92_uc003tua.2_Missense_Mutation_p.T202N|ZNF92_uc010kzu.2_Missense_Mutation_p.T239N|ZNF92_uc003tub.2_Missense_Mutation_p.T195N	NM_152626	NP_689839	Q03936	ZNF92_HUMAN	zinc finger protein 92 isoform 2	271	C2H2-type 5.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Lung NSC(55;0.159)				CGGTCCTCAACCCTTACTAAAC	0.351		NaN											0	0	0	0.115264	0	3	53									
CYP3A7	1551	broad.mit.edu	37	7	99308460	99308460	+	Nonsense_Mutation	SNP	A	A	C			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr7:99308460A>C	uc003uru.2	-	10	1026	c.921T>G	c.(919-921)TAT>TAG	p.Y307*	ZNF498_uc003urn.2_Intron|CYP3A5_uc003urs.2_Intron|CYP3A5_uc010lgg.2_Intron	NM_000765	NP_000756	P24462	CP3A7_HUMAN	cytochrome P450, family 3, subfamily A,	307					xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding			ovary(1)	1	Lung NSC(181;0.0144)|Esophageal squamous(72;0.0166)|all_lung(186;0.0228)					TCGTGGTTTCATAGCCAGCAA	0.413		NaN											0	0	0	0.108266	0	24	40									
MUC17	140453	broad.mit.edu	37	7	100682156	100682156	+	Missense_Mutation	SNP	A	A	G	rs139444589	byFrequency	TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr7:100682156A>G	uc003uxp.1	+	3	7512	c.7459A>G	c.(7459-7461)ATG>GTG	p.M2487V	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	2487	Extracellular (Potential).|40.|59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					CAGCACACCTATGACCACTTC	0.493		NaN											0	0	0	0.132662	0	6	428									
MUC17	140453	broad.mit.edu	37	7	100682158	100682158	+	Missense_Mutation	SNP	G	G	C	rs147944556		TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr7:100682158G>C	uc003uxp.1	+	3	7514	c.7461G>C	c.(7459-7461)ATG>ATC	p.M2487I	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	2487	Extracellular (Potential).|40.|59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					GCACACCTATGACCACTTCTA	0.493		NaN											0	0	0	0.132662	0	6	416									
CAV2	858	broad.mit.edu	37	7	116139888	116139888	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr7:116139888C>G	uc003vid.2	+	1	445	c.53C>G	c.(52-54)TCC>TGC	p.S18C	CAV2_uc003vhv.2_Intron|CAV2_uc003vhw.2_Intron|CAV2_uc003vhx.2_Intron|CAV2_uc010lkb.1_Intron|CAV2_uc010lkc.2_Intron|CAV2_uc003vib.2_Intron|CAV2_uc003vhz.2_Intron|CAV2_uc003via.2_Intron|CAV1_uc010lkd.1_Intron|CAV1_uc010lke.1_Intron|CAV2_uc003vie.2_Missense_Mutation_p.S18C	NM_001233	NP_001224	P51636	CAV2_HUMAN	caveolin 2 isoform a and b	18	Cytoplasmic (Potential).				caveola assembly|endoplasmic reticulum organization|mitochondrion organization|negative regulation of endothelial cell proliferation|positive regulation of dopamine receptor signaling pathway|regulation of mitosis|skeletal muscle fiber development|vesicle docking|vesicle fusion	caveola|extrinsic to internal side of plasma membrane|Golgi membrane|integral to plasma membrane|membrane fraction|nucleus|perinuclear region of cytoplasm|transport vesicle	D1 dopamine receptor binding|protein homodimerization activity				0	all_epithelial(6;1.53e-06)|Lung NSC(10;0.00592)|all_lung(10;0.00642)		STAD - Stomach adenocarcinoma(10;0.00878)			GACGACGACTCCTACAGCCAC	0.682		NaN											0	0	0	0.115264	0	2	2									
RP1L1	94137	broad.mit.edu	37	8	10466059	10466059	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr8:10466059C>T	uc003wtc.2	-	4	5778	c.5549G>A	c.(5548-5550)GGT>GAT	p.G1850D		NM_178857	NP_849188	Q8IWN7	RP1L1_HUMAN	retinitis pigmentosa 1-like 1	1850					intracellular signal transduction					ovary(4)|breast(3)|central_nervous_system(1)	8				COAD - Colon adenocarcinoma(149;0.0811)		GGCCTCTACACCTTCTGACTC	0.642		NaN											0	0	0	0.02938	0	6	197									
ZNF395	55893	broad.mit.edu	37	8	28210752	28210752	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr8:28210752G>A	uc003xgq.2	-	5	845	c.757C>T	c.(757-759)CAT>TAT	p.H253Y	ZNF395_uc003xgt.2_Missense_Mutation_p.H253Y|ZNF395_uc003xgr.2_Missense_Mutation_p.H253Y|ZNF395_uc003xgs.2_Missense_Mutation_p.H253Y	NM_018660	NP_061130	Q9H8N7	ZN395_HUMAN	zinc finger protein 395	253					transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding				0		Ovarian(32;2.06e-05)		KIRC - Kidney renal clear cell carcinoma(542;0.102)|Kidney(114;0.123)|Colorectal(74;0.142)		TCAAAGCCATGATCAGTTTGG	0.587		NaN											0	0	0	0.045705	0	23	21									
ENPP2	5168	broad.mit.edu	37	8	120598469	120598469	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr8:120598469C>G	uc003yot.1	-	15	1410	c.1324G>C	c.(1324-1326)GAG>CAG	p.E442Q	ENPP2_uc011lic.1_5'Flank|ENPP2_uc003yor.1_Missense_Mutation_p.E81Q|ENPP2_uc003yos.1_Missense_Mutation_p.E494Q|ENPP2_uc010mdd.1_Missense_Mutation_p.E442Q	NM_001040092	NP_001035181	Q13822	ENPP2_HUMAN	autotaxin isoform 2 preproprotein	442					cellular component movement|chemotaxis|G-protein coupled receptor protein signaling pathway|immune response|phosphate metabolic process|phosphatidylcholine catabolic process|regulation of cell migration	extracellular space|integral to plasma membrane	alkylglycerophosphoethanolamine phosphodiesterase activity|calcium ion binding|lysophospholipase activity|nucleic acid binding|nucleotide diphosphatase activity|phosphodiesterase I activity|polysaccharide binding|scavenger receptor activity|transcription factor binding|zinc ion binding			ovary(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)|large_intestine(1)|kidney(1)	7	Lung NSC(37;5.03e-06)|Ovarian(258;0.0249)|Hepatocellular(40;0.161)		STAD - Stomach adenocarcinoma(47;0.00185)			TGGATATCCTCAATTCTTCTG	0.413		NaN											0	0	0	0.108266	0	25	60									
KIAA0368	23392	broad.mit.edu	37	9	114206748	114206748	+	Missense_Mutation	SNP	A	A	C			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr9:114206748A>C	uc004bfe.1	-	5	714	c.714T>G	c.(712-714)AAT>AAG	p.N238K	KIAA0368_uc010muc.1_Missense_Mutation_p.N60K	NM_001080398	NP_001073867			KIAA0368 protein												0						TTATACGTTTATTCAGATGGA	0.388		NaN											0	0	0	0.080935	0	9	35									
C5	727	broad.mit.edu	37	9	123742496	123742496	+	Missense_Mutation	SNP	G	G	T			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr9:123742496G>T	uc004bkv.2	-	28	3553	c.3523C>A	c.(3523-3525)CTG>ATG	p.L1175M		NM_001735	NP_001726	P01031	CO5_HUMAN	complement component 5 preproprotein	1175					activation of MAPK activity|chemotaxis|complement activation, alternative pathway|complement activation, classical pathway|cytolysis|G-protein coupled receptor protein signaling pathway|inflammatory response|negative regulation of macrophage chemotaxis|positive regulation of chemokine secretion|positive regulation vascular endothelial growth factor production	extracellular space|membrane attack complex	chemokine activity|endopeptidase inhibitor activity			ovary(2)	2				OV - Ovarian serous cystadenocarcinoma(323;4.98e-53)|GBM - Glioblastoma multiforme(294;0.0242)	Eculizumab(DB01257)	TTTTCAAGCAGAAAGTTGTCA	0.408		NaN											1	0	1.04858e-14	0.058154	1.16417e-14	7	50									
ZNF79	7633	broad.mit.edu	37	9	130207140	130207140	+	Silent	SNP	A	A	G			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr9:130207140A>G	uc004bqw.3	+	5	1575	c.1161A>G	c.(1159-1161)AAA>AAG	p.K387K	ZNF79_uc011maf.1_Silent_p.K363K|ZNF79_uc011mag.1_Silent_p.K363K	NM_007135	NP_009066	Q15937	ZNF79_HUMAN	zinc finger protein 79	387					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)	1						CTGGGGAGAAACCCTACAAGT	0.532		NaN											0	0	0	0.02938	0	3	72									
C9orf119	375757	broad.mit.edu	37	9	131038427	131038427	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr9:131038427G>A	uc004bup.2	+	1	3	c.3G>A	c.(1-3)ATG>ATA	p.M1I	GOLGA2_uc011maw.1_5'Flank|GOLGA2_uc010mxw.2_5'Flank|GOLGA2_uc004bul.1_5'Flank|C9orf119_uc010mxx.1_Missense_Mutation_p.M1I	NM_001040011	NP_001035100	Q1ZZU3	SWI5_HUMAN	hypothetical protein LOC375757	1					double-strand break repair via homologous recombination	Swi5-Sfr1 complex	protein binding				0						GCGTGGCTATGCAGCGGCGTG	0.627		NaN											0	0	0	0.139131	0	45	57									
WDR34	89891	broad.mit.edu	37	9	131397988	131397988	+	Silent	SNP	C	C	A			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr9:131397988C>A	uc004bvq.1	-	5	886	c.762G>T	c.(760-762)CTG>CTT	p.L254L	WDR34_uc004bvs.1_Silent_p.L245L|WDR34_uc004bvr.1_Silent_p.L254L	NM_052844	NP_443076	Q96EX3	WDR34_HUMAN	WD repeat domain 34	254	WD 1.					cytoplasm				central_nervous_system(2)|skin(1)	3						TGCGCCACAGCAGCGGGTCCT	0.692		NaN											1	0	0.00909568	0.009096	0.00949993	3	38									
WNK3	65267	broad.mit.edu	37	X	54321158	54321158	+	Missense_Mutation	SNP	C	C	G	rs149832313	byFrequency	TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chrX:54321158C>G	uc004dtd.1	-	8	1960	c.1521G>C	c.(1519-1521)AGG>AGC	p.R507S	WNK3_uc004dtc.1_Missense_Mutation_p.R507S	NM_001002838	NP_001002838	Q9BYP7	WNK3_HUMAN	WNK lysine deficient protein kinase 3 isoform 2	507					intracellular protein kinase cascade|positive regulation of establishment of protein localization in plasma membrane|positive regulation of peptidyl-threonine phosphorylation|positive regulation of rubidium ion transmembrane transporter activity|positive regulation of rubidium ion transport|positive regulation of sodium ion transmembrane transporter activity|positive regulation of sodium ion transport|protein autophosphorylation	adherens junction|tight junction	ATP binding|protein binding|protein serine/threonine kinase activity|rubidium ion transmembrane transporter activity|sodium ion transmembrane transporter activity			lung(4)|ovary(3)|kidney(2)|central_nervous_system(2)	11						ACTGAGAATCCCTGCGTTCTT	0.478		NaN											0	0	0	0.134883	0	27	2									
MAGEC1	9947	broad.mit.edu	37	X	140994960	140994960	+	Silent	SNP	G	G	A			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chrX:140994960G>A	uc004fbt.2	+	4	2056	c.1770G>A	c.(1768-1770)CTG>CTA	p.L590L	MAGEC1_uc010nsl.1_Intron	NM_005462	NP_005453	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	590							protein binding			ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	4	Acute lymphoblastic leukemia(192;6.56e-05)					AGGACTCCCTGTCTCCTCACT	0.567		NaN								HNSCC(15;0.026)			0	0	0	0.02938	0	6	249									
SLC5A11	115584	broad.mit.edu	37	16	24921737	24921739	+	In_Frame_Del	DEL	CAG	CAG	-			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr16:24921737_24921739delCAG	uc002dmu.2	+	15	1993_1995	c.1761_1763delCAG	c.(1759-1764)GCCAGC>GCC	p.S592del	SLC5A11_uc002dms.2_In_Frame_Del_p.S528del|SLC5A11_uc010vcd.1_In_Frame_Del_p.S557del|SLC5A11_uc002dmt.2_In_Frame_Del_p.S436del|SLC5A11_uc010vce.1_In_Frame_Del_p.S522del|SLC5A11_uc010bxt.2_In_Frame_Del_p.S528del|SLC5A11_uc002dmv.2_In_Frame_Del_p.S215del	NM_052944	NP_443176	Q8WWX8	SC5AB_HUMAN	solute carrier family 5 (sodium/glucose	592	Cytoplasmic (Potential).				apoptosis|carbohydrate transport|sodium ion transport	integral to membrane|plasma membrane	polyol transmembrane transporter activity|symporter activity			ovary(2)	2				GBM - Glioblastoma multiforme(48;0.0365)		TGCCAGAGGCCAGCAGCAGCAGC	0.542		NaN											NaN	NaN	NaN	NaN	NaN	18	826	---	---							
TAOK2	9344	broad.mit.edu	37	16	29998498	29998500	+	In_Frame_Del	DEL	CTG	CTG	-			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr16:29998498_29998500delCTG	uc002dva.1	+	16	3688_3690	c.2905_2907delCTG	c.(2905-2907)CTGdel	p.L974del	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|TAOK2_uc002dvb.1_Intron|TAOK2_uc002dvc.1_Intron|TAOK2_uc010bzm.1_In_Frame_Del_p.L981del|TAOK2_uc002dvd.1_In_Frame_Del_p.L801del	NM_016151	NP_057235	Q9UL54	TAOK2_HUMAN	TAO kinase 2 isoform 2	974	Leu-rich.|Helical; (Potential).				actin cytoskeleton organization|activation of MAPKK activity|apoptosis|cell migration|focal adhesion assembly|positive regulation of JNK cascade|protein targeting to membrane|regulation of cell growth|regulation of cell shape|response to stress	cytoplasmic vesicle membrane|cytoskeleton|dendrite|integral to membrane|nucleolus	ATP binding|protein serine/threonine kinase activity			ovary(1)	1						CCTGCCCCTCCTGCTGCTGCTGC	0.709		NaN											NaN	NaN	NaN	NaN	NaN	7	435	---	---							
ZNF513	130557	broad.mit.edu	37	2	27600891	27600892	+	Frame_Shift_Del	DEL	TG	TG	-			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr2:27600891_27600892delTG	uc002rkk.2	-	4	1346_1347	c.1146_1147delCA	c.(1144-1149)CACAGTfs	p.H382fs	ZNF513_uc002rkj.2_Frame_Shift_Del_p.H320fs	NM_144631	NP_653232	Q8N8E2	ZN513_HUMAN	zinc finger protein 513	382_383					regulation of transcription, DNA-dependent|response to stimulus|retina development in camera-type eye|transcription, DNA-dependent|visual perception	nucleus	transcription regulatory region DNA binding|zinc ion binding	p.S383C(1)		ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TTCTCACCACTGTGTGTCTTCA	0.609		NaN											NaN	NaN	NaN	NaN	NaN	57	160	---	---