Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
C11orf16	56673	broad.mit.edu	37	11	8947013	8947013	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A5BR-01A-11D-A26M-08	TCGA-FD-A5BR-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afafc062-4c58-491a-8c4b-e714591ac2c2	2c6c386c-6fe4-4b77-ab2b-893aca19a3c6	g.chr11:8947013G>T	ENST00000326053.5	-	5	1307	c.1201C>A	c.(1201-1203)Cca>Aca	p.P401T	C11orf16_ENST00000525780.1_Missense_Mutation_p.P401T	NM_020643.2	NP_065694.2	Q9NQ32	CK016_HUMAN	chromosome 11 open reading frame 16	401										central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(10)|ovary(1)|pancreas(1)|prostate(1)|stomach(2)|upper_aerodigestive_tract(1)	22				Epithelial(150;4.11e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0234)		GGTATACCTGGCTTCCCAAGG	0.577000													27	22					1.7881e-09	2.15624e-09	1	1	0
ANKRD11	29123	broad.mit.edu	37	16	89347241	89347241	+	Silent	SNP	G	G	A			TCGA-FD-A5BR-01A-11D-A26M-08	TCGA-FD-A5BR-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afafc062-4c58-491a-8c4b-e714591ac2c2	2c6c386c-6fe4-4b77-ab2b-893aca19a3c6	g.chr16:89347241G>A	ENST00000301030.4	-	9	6169	c.5709C>T	c.(5707-5709)ctC>ctT	p.L1903L	ANKRD11_ENST00000378330.2_Silent_p.L1903L	NM_001256183.1|NM_013275.5	NP_001243112.1|NP_037407.4	Q6UB99	ANR11_HUMAN	ankyrin repeat domain 11	1903	Pro-rich.					nucleus				breast(4)|central_nervous_system(3)|endometrium(17)|kidney(2)|large_intestine(18)|lung(20)|ovary(6)|pancreas(1)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	83		all_hematologic(23;0.00824)|Colorectal(91;0.0475)		Epithelial(1;5.33e-11)|all cancers(4;2.6e-09)|OV - Ovarian serous cystadenocarcinoma(4;2.29e-07)|BRCA - Breast invasive adenocarcinoma(80;0.0142)		GGGCCCCTTCGAGGGAAGGAA	0.657000													33	57					0	0	1	0	0
PSIP1	11168	broad.mit.edu	37	9	15468626	15468626	+	Splice_Site	SNP	A	A	G			TCGA-FD-A5BR-01A-11D-A26M-08	TCGA-FD-A5BR-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afafc062-4c58-491a-8c4b-e714591ac2c2	2c6c386c-6fe4-4b77-ab2b-893aca19a3c6	g.chr9:15468626A>G	ENST00000380733.4	-	14	1764		c.e14+1		PSIP1_ENST00000380738.4_Splice_Site			O75475	PSIP1_HUMAN	PC4 and SFRS1 interacting protein 1						initiation of viral infection|interspecies interaction between organisms|nuclear mRNA 5'-splice site recognition|provirus integration|regulation of transcription, DNA-dependent|response to heat|response to oxidative stress|transcription, DNA-dependent	cytosol|nuclear heterochromatin|nuclear periphery|nucleoplasm|transcriptionally active chromatin	activating transcription factor binding|chromatin binding|DNA secondary structure binding|RNA polymerase II transcription coactivator activity			breast(2)|endometrium(2)|kidney(1)|lung(3)|prostate(1)	9				GBM - Glioblastoma multiforme(50;2.38e-06)		TTTACCACATACCTGTTTGTT	0.378000													22	46					0	0	1	0	0
DST	667	broad.mit.edu	37	6	56483414	56483414	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A5BR-01A-11D-A26M-08	TCGA-FD-A5BR-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afafc062-4c58-491a-8c4b-e714591ac2c2	2c6c386c-6fe4-4b77-ab2b-893aca19a3c6	g.chr6:56483414C>G	ENST00000370765.6	-	23	5525	c.5418G>C	c.(5416-5418)caG>caC	p.Q1806H	DST_ENST00000421834.2_Intron|DST_ENST00000370788.2_Intron|DST_ENST00000361203.3_Intron|DST_ENST00000312431.6_Intron|DST_ENST00000244364.6_Intron|DST_ENST00000446842.2_Intron|DST_ENST00000370769.4_Intron|DST_ENST00000370754.5_Intron	NM_001723.5	NP_001714.1	Q03001	DYST_HUMAN	dystonin	1214					cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			NS(1)|breast(5)|central_nervous_system(8)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(22)|lung(43)|ovary(7)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)	105	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			ACTGTTGAAGCTGTCTTTCAA	0.408000													29	64					0	0	1	0	0
CNTN2	6900	broad.mit.edu	37	1	205036280	205036280	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A5BR-01A-11D-A26M-08	TCGA-FD-A5BR-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afafc062-4c58-491a-8c4b-e714591ac2c2	2c6c386c-6fe4-4b77-ab2b-893aca19a3c6	g.chr1:205036280C>A	ENST00000331830.4	+	16	2311	c.2027C>A	c.(2026-2028)aCc>aAc	p.T676N		NM_005076.3	NP_005067.1	Q02246	CNTN2_HUMAN	contactin 2 (axonal)	676	Fibronectin type-III 1.				axon guidance|clustering of voltage-gated potassium channels	anchored to membrane|juxtaparanode region of axon|myelin sheath|node of Ranvier|synapse part	identical protein binding	p.T676N(1)		NS(1)|breast(4)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(11)|lung(23)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	54	all_cancers(21;0.144)|Breast(84;0.0437)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.158)			CTGGGCCTCACCCCCTGGATG	0.577000													39	81					4.32679e-17	5.66165e-17	1	1	0
NMD3	51068	broad.mit.edu	37	3	160964133	160964133	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A5BR-01A-11D-A26M-08	TCGA-FD-A5BR-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afafc062-4c58-491a-8c4b-e714591ac2c2	2c6c386c-6fe4-4b77-ab2b-893aca19a3c6	g.chr3:160964133G>A	ENST00000460469.1	+	11	1482	c.1027G>A	c.(1027-1029)Ggg>Agg	p.G343R	NMD3_ENST00000472947.1_Missense_Mutation_p.G343R|NMD3_ENST00000351193.2_Missense_Mutation_p.G343R			Q96D46	NMD3_HUMAN	NMD3 ribosome export adaptor	343					protein transport	cytoplasm|nucleolus|nucleoplasm		p.G343W(1)		cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(7)|lung(10)|ovary(1)|skin(1)|urinary_tract(2)	25			Lung(72;0.00111)|LUSC - Lung squamous cell carcinoma(72;0.00156)			GCATACCCTCGGGGAAGTCTG	0.353000													10	18					0	0	1	0	0
NBPF10	100132406	broad.mit.edu	37	1	145302714	145302714	+	Silent	SNP	A	A	G	rs9424867		TCGA-FD-A5BR-01A-11D-A26M-08	TCGA-FD-A5BR-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afafc062-4c58-491a-8c4b-e714591ac2c2	2c6c386c-6fe4-4b77-ab2b-893aca19a3c6	g.chr1:145302714A>G	ENST00000342960.5	+	8	1187	c.1152A>G	c.(1150-1152)ttA>ttG	p.L384L	RP11-458D21.5_ENST00000468030.1_3'UTR|NBPF10_ENST00000369338.1_Silent_p.L113L|NBPF10_ENST00000369339.3_Silent_p.L113L	NM_001039703.4	NP_001034792.4	A6NDV3	A6NDV3_HUMAN	neuroblastoma breakpoint family, member 10	384								p.L113L(3)|p.L384L(3)		NS(3)|breast(1)|central_nervous_system(3)|endometrium(12)|kidney(23)|lung(15)|ovary(1)|prostate(7)|skin(6)|urinary_tract(2)	73	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		AGGAGAAGTTACGGGAAGGGA	0.527000													6	59					0	0	1	0	0
CCDC30	728621	broad.mit.edu	37	1	43102993	43102993	+	Nonsense_Mutation	SNP	A	A	T			TCGA-FD-A5BR-01A-11D-A26M-08	TCGA-FD-A5BR-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afafc062-4c58-491a-8c4b-e714591ac2c2	2c6c386c-6fe4-4b77-ab2b-893aca19a3c6	g.chr1:43102993A>T	ENST00000428554.2	+	18	2725	c.1582A>T	c.(1582-1584)Aag>Tag	p.K528*	CCDC30_ENST00000340612.4_Nonsense_Mutation_p.K528*|CCDC30_ENST00000342022.4_Nonsense_Mutation_p.K528*|CCDC30_ENST00000507855.1_Nonsense_Mutation_p.K317*|CCDC30_ENST00000390640.4_Nonsense_Mutation_p.K317*			Q5VVM6	CCD30_HUMAN	coiled-coil domain containing 30	528										endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(11)|ovary(1)|pancreas(1)|prostate(1)|urinary_tract(2)	30						ACTACGAGATAAGAGAATTAA	0.308000													4	41					0	0	1	0	0
KIAA1614	57710	broad.mit.edu	37	1	180913531	180913531	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A5BR-01A-11D-A26M-08	TCGA-FD-A5BR-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afafc062-4c58-491a-8c4b-e714591ac2c2	2c6c386c-6fe4-4b77-ab2b-893aca19a3c6	g.chr1:180913531C>A	ENST00000367588.4	+	8	3221	c.3166C>A	c.(3166-3168)Ccc>Acc	p.P1056T	KIAA1614_ENST00000367587.1_Missense_Mutation_p.P677T|RP11-46A10.5_ENST00000358073.2_RNA|KIAA1614_ENST00000461346.1_3'UTR	NM_020950.1	NP_066001.1	Q5VZ46	K1614_HUMAN	KIAA1614	1056	Ser-rich.									NS(1)|endometrium(5)|kidney(2)|large_intestine(2)|lung(12)|ovary(5)|pancreas(1)|prostate(1)|skin(3)|urinary_tract(1)	33						TCAGGTGTCACCCTCTCACCA	0.572000													12	55					0.000422831	0.000448347	1	1	0
HIVEP1	3096	broad.mit.edu	37	6	12161748	12161748	+	Missense_Mutation	SNP	T	T	A			TCGA-FD-A5BR-01A-11D-A26M-08	TCGA-FD-A5BR-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afafc062-4c58-491a-8c4b-e714591ac2c2	2c6c386c-6fe4-4b77-ab2b-893aca19a3c6	g.chr6:12161748T>A	ENST00000379388.2	+	8	6896	c.6564T>A	c.(6562-6564)aaT>aaA	p.N2188K	HIVEP1_ENST00000541134.1_Missense_Mutation_p.N53K	NM_002114.2	NP_002105.2	P15822	ZEP1_HUMAN	human immunodeficiency virus type I enhancer binding protein 1	2188					transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|protein binding|zinc ion binding			NS(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(11)|liver(1)|lung(31)|ovary(4)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(3)	90	Breast(50;0.0639)|Ovarian(93;0.0816)	all_hematologic(90;0.117)				AGGATGACAATGAAAATGAAG	0.453000													26	37					0	0	1	0	0
DTWD1	56986	broad.mit.edu	37	15	49917391	49917391	+	Silent	SNP	C	C	G			TCGA-FD-A5BR-01A-11D-A26M-08	TCGA-FD-A5BR-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afafc062-4c58-491a-8c4b-e714591ac2c2	2c6c386c-6fe4-4b77-ab2b-893aca19a3c6	g.chr15:49917391C>G	ENST00000251250.6	+	3	234	c.27C>G	c.(25-27)ctC>ctG	p.L9L	DTWD1_ENST00000558653.1_Silent_p.L9L|DTWD1_ENST00000403028.3_Silent_p.L9L|DTWD1_ENST00000329873.5_Silent_p.L9L|DTWD1_ENST00000559223.1_3'UTR	NM_020234.5	NP_064619.2	Q8N5C7	DTWD1_HUMAN	DTW domain containing 1	9			L -> P (in dbSNP:rs11539522).							endometrium(1)|large_intestine(4)|lung(2)|ovary(1)|upper_aerodigestive_tract(1)	9		all_lung(180;0.0384)		all cancers(107;3.27e-08)|GBM - Glioblastoma multiforme(94;7.6e-05)		CTATATTTCTCAAACGAAGTG	0.323000													6	18					0	0	1	0	0
WRN	7486	broad.mit.edu	37	8	31024662	31024662	+	Silent	SNP	C	C	A			TCGA-FD-A5BR-01A-11D-A26M-08	TCGA-FD-A5BR-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afafc062-4c58-491a-8c4b-e714591ac2c2	2c6c386c-6fe4-4b77-ab2b-893aca19a3c6	g.chr8:31024662C>A	ENST00000298139.5	+	34	4356	c.4107C>A	c.(4105-4107)gtC>gtA	p.V1369V	RP11-363L24.3_ENST00000521252.1_RNA	NM_000553.4	NP_000544.2	Q14191	WRN_HUMAN	Werner syndrome, RecQ helicase-like	1369					base-excision repair|cellular response to starvation|DNA recombination|DNA synthesis involved in DNA repair|multicellular organismal aging|nucleolus to nucleoplasm transport|positive regulation of hydrolase activity|regulation of apoptosis|replication fork processing|response to oxidative stress|response to UV-C|telomere maintenance	centrosome|nucleolus|nucleoplasm	3'-5' exonuclease activity|ATP binding|ATP-dependent 3'-5' DNA helicase activity|bubble DNA binding|four-way junction helicase activity|G-quadruplex DNA binding|magnesium ion binding|manganese ion binding|protein complex binding|protein homodimerization activity|Y-form DNA binding			central_nervous_system(2)|endometrium(4)|kidney(4)|large_intestine(13)|lung(28)|ovary(3)|skin(3)|upper_aerodigestive_tract(3)	60		Breast(100;0.195)		KIRC - Kidney renal clear cell carcinoma(542;0.147)|Kidney(114;0.176)|Colorectal(111;0.192)		CATGTGATGTCAACAAAAGGA	0.388000			"""Mis, N, F, S"""			"""osteosarcoma, meningioma, others"""		Genes defective in diseases associated with sensitivity to DNA damaging agents	Werner syndrome				9	34					0.00621372	0.00647701	1	1	0
KLC4	89953	broad.mit.edu	37	6	43029073	43029073	+	Translation_Start_Site	SNP	G	G	A			TCGA-FD-A5BR-01A-11D-A26M-08	TCGA-FD-A5BR-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afafc062-4c58-491a-8c4b-e714591ac2c2	2c6c386c-6fe4-4b77-ab2b-893aca19a3c6	g.chr6:43029073G>A	ENST00000394056.2	+	0	495				KLC4_ENST00000259708.3_Silent_p.R18R|KLC4_ENST00000453940.2_De_novo_Start_InFrame|KLC4_ENST00000479388.1_De_novo_Start_InFrame|KLC4_ENST00000347162.5_De_novo_Start_InFrame|KLC4_ENST00000458460.2_De_novo_Start_InFrame|KLC4_ENST00000394058.1_De_novo_Start_InFrame			Q9NSK0	KLC4_HUMAN	kinesin light chain 4							cytoplasm|kinesin complex|microtubule	microtubule motor activity|protein binding			endometrium(2)|large_intestine(7)|lung(5)|ovary(1)|pancreas(1)|skin(3)|urinary_tract(4)	23			all cancers(41;0.00169)|Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|OV - Ovarian serous cystadenocarcinoma(102;0.0376)|KIRC - Kidney renal clear cell carcinoma(2;0.0453)			CCCAGGCCAGGATGTCAGGCC	0.602000													7	81					0	0	1	0	0
FLG2	388698	broad.mit.edu	37	1	152324561	152324561	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A5BR-01A-11D-A26M-08	TCGA-FD-A5BR-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afafc062-4c58-491a-8c4b-e714591ac2c2	2c6c386c-6fe4-4b77-ab2b-893aca19a3c6	g.chr1:152324561G>A	ENST00000388718.5	-	3	5773	c.5701C>T	c.(5701-5703)Cac>Tac	p.H1901Y	FLG-AS1_ENST00000392688.2_RNA|FLG-AS1_ENST00000445097.1_RNA	NM_001014342.2	NP_001014364.1	Q5D862	FILA2_HUMAN	filaggrin family member 2	1901							calcium ion binding|structural molecule activity			NS(2)|breast(7)|cervix(3)|endometrium(11)|kidney(9)|large_intestine(24)|liver(1)|lung(85)|ovary(12)|pancreas(1)|prostate(6)|skin(17)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(5)	188	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GCTTGGCTGTGTGTGTGTCCT	0.507000													72	164					0	0	1	0	0
LPA	4018	broad.mit.edu	37	6	161007551	161007551	+	Silent	SNP	C	C	T			TCGA-FD-A5BR-01A-11D-A26M-08	TCGA-FD-A5BR-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afafc062-4c58-491a-8c4b-e714591ac2c2	2c6c386c-6fe4-4b77-ab2b-893aca19a3c6	g.chr6:161007551C>T	ENST00000447678.1	-	26	4179	c.4059G>A	c.(4057-4059)gtG>gtA	p.V1353V	LPA_ENST00000316300.5_Silent_p.V1353V	NM_005577.2	NP_005568.2	P08519	APOA_HUMAN	lipoprotein, Lp(a)	3861	Kringle 12.				blood circulation|lipid metabolic process|lipid transport|lipoprotein metabolic process|proteolysis|receptor-mediated endocytosis	plasma lipoprotein particle	apolipoprotein binding|endopeptidase inhibitor activity|fibronectin binding|heparin binding|serine-type endopeptidase activity			NS(1)|breast(3)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(16)|lung(54)|ovary(4)|pancreas(1)|prostate(2)|skin(10)|stomach(1)|urinary_tract(1)	107		Breast(66;0.000496)|Ovarian(120;0.0303)|Prostate(117;0.0965)		OV - Ovarian serous cystadenocarcinoma(65;2.5e-17)|BRCA - Breast invasive adenocarcinoma(81;6.48e-06)	Aminocaproic Acid(DB00513)	TTGATTCCATCACTGGACATT	0.512000													16	80					0	0	1	0	0
COL6A3	1293	broad.mit.edu	37	2	238275412	238275412	+	Silent	SNP	G	G	A			TCGA-FD-A5BR-01A-11D-A26M-08	TCGA-FD-A5BR-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afafc062-4c58-491a-8c4b-e714591ac2c2	2c6c386c-6fe4-4b77-ab2b-893aca19a3c6	g.chr2:238275412G>A	ENST00000295550.4	-	11	5870	c.5418C>T	c.(5416-5418)tcC>tcT	p.S1806S	COL6A3_ENST00000472056.1_Silent_p.S1199S|COL6A3_ENST00000353578.4_Silent_p.S1600S|COL6A3_ENST00000347401.3_Silent_p.S1605S|COL6A3_ENST00000409809.1_Silent_p.S1600S|COL6A3_ENST00000346358.4_Silent_p.S1606S	NM_004369.3	NP_004360.2	P12111	CO6A3_HUMAN	collagen, type VI, alpha 3	1806	Nonhelical region.|VWFA 9.				axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			breast(6)|central_nervous_system(7)|cervix(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(64)|lung(62)|ovary(14)|pancreas(2)|prostate(11)|skin(14)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(4)	217		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		CGCTCAGTTCGGACAGCTCCT	0.522000													23	86					0	0	1	0	0
CLIP1	6249	broad.mit.edu	37	12	122848560	122848560	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A5BR-01A-11D-A26M-08	TCGA-FD-A5BR-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afafc062-4c58-491a-8c4b-e714591ac2c2	2c6c386c-6fe4-4b77-ab2b-893aca19a3c6	g.chr12:122848560C>A	ENST00000358808.2	-	4	906	c.752G>T	c.(751-753)gGg>gTg	p.G251V	CLIP1_ENST00000545889.1_5'UTR|CLIP1_ENST00000537178.1_Missense_Mutation_p.G251V|CLIP1_ENST00000540338.1_Missense_Mutation_p.G251V|CLIP1_ENST00000302528.7_Missense_Mutation_p.G251V|CLIP1_ENST00000361654.4_Missense_Mutation_p.G251V	NM_001247997.1|NM_002956.2	NP_001234926.1|NP_002947.1	P30622	CLIP1_HUMAN	CAP-GLY domain containing linker protein 1	251	CAP-Gly 2.				mitotic prometaphase|positive regulation of microtubule polymerization	centrosome|cytosol|endosome|intermediate filament|kinetochore	nucleic acid binding|protein homodimerization activity|zinc ion binding			NS(1)|breast(5)|endometrium(4)|kidney(5)|large_intestine(16)|liver(1)|lung(21)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	60	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.81e-05)|Epithelial(86;6.85e-05)|BRCA - Breast invasive adenocarcinoma(302;0.226)		ATCATTCTTCCCAAGTGGCTC	0.537000													10	32					7.48243e-07	8.52165e-07	1	1	0
PC	5091	broad.mit.edu	37	11	66636369	66636369	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A5BR-01A-11D-A26M-08	TCGA-FD-A5BR-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afafc062-4c58-491a-8c4b-e714591ac2c2	2c6c386c-6fe4-4b77-ab2b-893aca19a3c6	g.chr11:66636369C>T	ENST00000393960.1	-	10	1251	c.970G>A	c.(970-972)Gag>Aag	p.E324K	PC_ENST00000355677.3_Missense_Mutation_p.E324K|PC_ENST00000524491.1_Missense_Mutation_p.E284K|PC_ENST00000393955.2_Missense_Mutation_p.E324K|PC_ENST00000393958.2_Missense_Mutation_p.E324K	NM_001040716.1	NP_001035806.1	P11498	PYC_HUMAN	pyruvate carboxylase	324	ATP-grasp.|Biotin carboxylation.				gluconeogenesis|lipid biosynthetic process	mitochondrial matrix	ATP binding|biotin binding|biotin carboxylase activity|metal ion binding|pyruvate carboxylase activity			cervix(1)|endometrium(3)|kidney(3)|large_intestine(9)|lung(12)|ovary(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	32		Melanoma(852;0.0525)		Lung(977;0.153)|LUSC - Lung squamous cell carcinoma(976;0.227)	Biotin(DB00121)|Pyruvic acid(DB00119)	GAGTTGACCTCGATGAAGTAG	0.662000													40	59					0	0	1	0	0
PCDHGA5	56110	broad.mit.edu	37	5	140745457	140745457	+	Silent	SNP	C	C	T			TCGA-FD-A5BR-01A-11D-A26M-08	TCGA-FD-A5BR-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afafc062-4c58-491a-8c4b-e714591ac2c2	2c6c386c-6fe4-4b77-ab2b-893aca19a3c6	g.chr5:140745457C>T	ENST00000518069.1	+	1	1560	c.1560C>T	c.(1558-1560)ttC>ttT	p.F520F	PCDHGA2_ENST00000394576.2_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGB1_ENST00000523390.1_Intron	NM_018918.2|NM_032054.1	NP_061741.1|NP_114443.1														endometrium(1)|kidney(1)|large_intestine(5)|lung(3)|ovary(5)|upper_aerodigestive_tract(3)	18			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGAGATCCTTCGACTATGAGC	0.542000													15	199					0	0	1	0	0
GALP	85569	broad.mit.edu	37	19	56693616	56693616	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A5BR-01A-11D-A26M-08	TCGA-FD-A5BR-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afafc062-4c58-491a-8c4b-e714591ac2c2	2c6c386c-6fe4-4b77-ab2b-893aca19a3c6	g.chr19:56693616C>A	ENST00000357330.2	+	4	294	c.212C>A	c.(211-213)gCc>gAc	p.A71D	GALP_ENST00000440823.1_3'UTR	NM_033106.3	NP_149097.1	Q9UBC7	GALP_HUMAN	galanin-like peptide	71					neuropeptide signaling pathway	extracellular region	hormone activity			lung(4)	4		Colorectal(82;0.000147)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0507)		CTGTGGAAGGCCATCGGTGAG	0.582000													8	53					0.000157383	0.000171311	1	1	0
SULF1	23213	broad.mit.edu	37	8	70512953	70512953	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A5BR-01A-11D-A26M-08	TCGA-FD-A5BR-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afafc062-4c58-491a-8c4b-e714591ac2c2	2c6c386c-6fe4-4b77-ab2b-893aca19a3c6	g.chr8:70512953C>A	ENST00000260128.4	+	9	1567	c.850C>A	c.(850-852)Cag>Aag	p.Q284K	SULF1_ENST00000458141.2_Missense_Mutation_p.Q284K|SULF1_ENST00000521946.1_3'UTR|SULF1_ENST00000419716.3_Missense_Mutation_p.Q284K|SULF1_ENST00000402687.4_Missense_Mutation_p.Q284K	NM_015170.2	NP_055985.2	Q8IWU6	SULF1_HUMAN	sulfatase 1	284					apoptosis|bone development|heparan sulfate proteoglycan metabolic process|kidney development|negative regulation of fibroblast growth factor receptor signaling pathway	cell surface|endoplasmic reticulum|extracellular space|Golgi stack	arylsulfatase activity|calcium ion binding			breast(2)|central_nervous_system(3)|endometrium(5)|kidney(3)|large_intestine(10)|lung(15)|ovary(3)|pancreas(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	52	Breast(64;0.0654)		Epithelial(68;0.0124)|OV - Ovarian serous cystadenocarcinoma(28;0.0265)|all cancers(69;0.0534)			CAAAAGGCTCCAGACTTTGAT	0.433000													10	178					4.68919e-08	5.49305e-08	1	1	0
HOOK2	29911	broad.mit.edu	37	19	12874211	12874211	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A5BR-01A-11D-A26M-08	TCGA-FD-A5BR-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afafc062-4c58-491a-8c4b-e714591ac2c2	2c6c386c-6fe4-4b77-ab2b-893aca19a3c6	g.chr19:12874211C>T	ENST00000264827.5	-	22	2209	c.2039G>A	c.(2038-2040)cGg>cAg	p.R680Q	HOOK2_ENST00000397668.3_Missense_Mutation_p.R682Q	NM_001100176.1	NP_001093646.1	Q96ED9	HOOK2_HUMAN	hook microtubule-tethering protein 2	682	Required for localization to the centrosome and induction of aggresome formation.|Sufficient for interaction with CEP110.				early endosome to late endosome transport|endocytosis|endosome organization|endosome to lysosome transport|lysosome organization|microtubule cytoskeleton organization|protein transport	centrosome|FHF complex|microtubule	identical protein binding|microtubule binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(7)|ovary(1)|prostate(5)|skin(1)	20						GGCAGGCGCCCGCTCCTCCCC	0.642000													15	105					0	0	1	0	0
NXF1	10482	broad.mit.edu	37	11	62572815	62572815	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A5BR-01A-11D-A26M-08	TCGA-FD-A5BR-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afafc062-4c58-491a-8c4b-e714591ac2c2	2c6c386c-6fe4-4b77-ab2b-893aca19a3c6	g.chr11:62572815C>G	ENST00000531709.2	-	1	127	c.14G>C	c.(13-15)gGg>gCg	p.G5A	NXF1_ENST00000532297.1_Missense_Mutation_p.G5A|NXF1_ENST00000294172.2_Missense_Mutation_p.G5A|NXF1_ENST00000531131.1_5'UTR|NXF1_ENST00000439713.2_Missense_Mutation_p.G5A	NM_001081491.1	NP_001074960.1	Q9UBU9	NXF1_HUMAN	nuclear RNA export factor 1	5	Interaction with THOC4.				gene expression|interspecies interaction between organisms	cytosol|nuclear speck	nucleotide binding|protein binding			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(9)|lung(13)|ovary(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	39						GTACGACTTCCCCTCGTCCGC	0.682000													21	48					0	0	1	0	0
GAB1	2549	broad.mit.edu	37	4	144359596	144359596	+	Silent	SNP	G	G	A			TCGA-FD-A5BR-01A-11D-A26M-08	TCGA-FD-A5BR-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afafc062-4c58-491a-8c4b-e714591ac2c2	2c6c386c-6fe4-4b77-ab2b-893aca19a3c6	g.chr4:144359596G>A	ENST00000262995.4	+	4	1465	c.1038G>A	c.(1036-1038)ccG>ccA	p.P346P	GAB1_ENST00000262994.4_Silent_p.P346P|GAB1_ENST00000505913.1_Silent_p.P243P	NM_207123.2	NP_997006.1	Q13480	GAB1_HUMAN	GRB2-associated binding protein 1	346					cell proliferation|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway	cytosol	SH3/SH2 adaptor activity	p.P346P(1)		breast(3)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(7)|lung(10)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	30	all_hematologic(180;0.158)					CTCGGCCACCGAAACCACATC	0.493000													5	68					0	0	1	0	0
IRF7	3665	broad.mit.edu	37	11	613104	613104	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A5BR-01A-11D-A26M-08	TCGA-FD-A5BR-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afafc062-4c58-491a-8c4b-e714591ac2c2	2c6c386c-6fe4-4b77-ab2b-893aca19a3c6	g.chr11:613104G>T	ENST00000397566.1	-	8	1699	c.1290C>A	c.(1288-1290)ttC>ttA	p.F430L	IRF7_ENST00000330243.5_Missense_Mutation_p.F430L|IRF7_ENST00000397570.1_Missense_Mutation_p.F388L|IRF7_ENST00000397574.2_Missense_Mutation_p.F417L|IRF7_ENST00000397562.3_Missense_Mutation_p.F124L|IRF7_ENST00000525445.1_Missense_Mutation_p.F311L|IRF7_ENST00000348655.6_Missense_Mutation_p.F388L	NM_004031.2	NP_004022.2	Q92985	IRF7_HUMAN	interferon regulatory factor 7	417					interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|MyD88-independent toll-like receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|positive regulation of interferon-alpha production|positive regulation of transcription from RNA polymerase II promoter|response to virus|Toll signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|transcription from RNA polymerase II promoter|type I interferon-mediated signaling pathway	cytosol|endosome membrane|nucleoplasm|plasma membrane	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			endometrium(1)|kidney(1)|large_intestine(1)|lung(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	8		all_cancers(49;1.69e-08)|all_epithelial(84;1.65e-05)|Breast(177;0.000231)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.106)|all_lung(207;0.136)		all cancers(45;7.68e-28)|Epithelial(43;7.44e-27)|OV - Ovarian serous cystadenocarcinoma(40;3.53e-21)|BRCA - Breast invasive adenocarcinoma(625;6.96e-05)|Lung(200;0.0375)|LUSC - Lung squamous cell carcinoma(625;0.0703)		GCCGTGCCCGGAATTCCACCA	0.652000													16	30					0.000422831	0.000448347	1	1	0
POMGNT1	55624	broad.mit.edu	37	1	46654596	46654596	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A5BR-01A-11D-A26M-08	TCGA-FD-A5BR-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afafc062-4c58-491a-8c4b-e714591ac2c2	2c6c386c-6fe4-4b77-ab2b-893aca19a3c6	g.chr1:46654596G>A	ENST00000371992.1	-	23	2692	c.2042C>T	c.(2041-2043)cCg>cTg	p.P681L	POMGNT1_ENST00000396420.3_3'UTR|POMGNT1_ENST00000371984.3_3'UTR|POMGNT1_ENST00000535522.1_3'UTR|POMGNT1_ENST00000371986.3_Missense_Mutation_p.P681L	NM_001243766.1	NP_001230695	Q8WZA1	PMGT1_HUMAN	protein O-linked mannose N-acetylglucosaminyltransferase 1 (beta 1,2-)	0					protein N-linked glycosylation|protein O-linked glycosylation	Golgi membrane|integral to membrane|microsome	alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity|beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity			breast(2)|endometrium(3)|kidney(2)|large_intestine(3)|lung(3)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	20	Acute lymphoblastic leukemia(166;0.155)					CTCCAGGTTCGGCCTGTTTTC	0.547000													6	52					0	0	1	0	0
NLGN1	22871	broad.mit.edu	37	3	173525587	173525587	+	Missense_Mutation	SNP	T	T	G			TCGA-FD-A5BR-01A-11D-A26M-08	TCGA-FD-A5BR-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afafc062-4c58-491a-8c4b-e714591ac2c2	2c6c386c-6fe4-4b77-ab2b-893aca19a3c6	g.chr3:173525587T>G	ENST00000457714.1	+	4	1040	c.611T>G	c.(610-612)aTc>aGc	p.I204S	NLGN1_ENST00000545397.1_Missense_Mutation_p.I204S|NLGN1_ENST00000361589.4_Missense_Mutation_p.I204S|NLGN1_ENST00000401917.3_Missense_Mutation_p.I244S	NM_014932.2	NP_055747.1	Q8N2Q7	NLGN1_HUMAN	neuroligin 1	221					calcium-dependent cell-cell adhesion|neuron cell-cell adhesion|neuronal signal transduction|positive regulation of dendritic spine development|positive regulation of excitatory postsynaptic membrane potential|positive regulation of intracellular protein kinase cascade|positive regulation of synaptogenesis|protein targeting|regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|regulation of N-methyl-D-aspartate selective glutamate receptor activity|synapse assembly|synaptic vesicle targeting	cell junction|cell surface|dendrite|integral to plasma membrane|postsynaptic density|postsynaptic membrane	cell adhesion molecule binding|neurexin binding|receptor activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(9)|liver(2)|lung(54)|ovary(1)|pancreas(1)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	83	Ovarian(172;0.0025)		LUSC - Lung squamous cell carcinoma(14;5.36e-13)|Lung(28;9.49e-13)			GGCAATGTGATCGTCATCACA	0.408000													18	46					0	0	1	0	0
SLC27A2	11001	broad.mit.edu	37	15	50521168	50521168	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A5BR-01A-11D-A26M-08	TCGA-FD-A5BR-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afafc062-4c58-491a-8c4b-e714591ac2c2	2c6c386c-6fe4-4b77-ab2b-893aca19a3c6	g.chr15:50521168C>T	ENST00000267842.5	+	8	1716	c.1484C>T	c.(1483-1485)aCt>aTt	p.T495I	SLC27A2_ENST00000544960.1_Missense_Mutation_p.T260I|SLC27A2_ENST00000380902.4_Missense_Mutation_p.T442I	NM_003645.3	NP_003636.2	O14975	S27A2_HUMAN	solute carrier family 27 (fatty acid transporter), member 2	495					bile acid biosynthetic process|fatty acid alpha-oxidation	endoplasmic reticulum membrane|integral to membrane|peroxisomal matrix|peroxisomal membrane	ATP binding|long-chain fatty acid-CoA ligase activity|phytanate-CoA ligase activity|pristanate-CoA ligase activity			NS(1)|breast(2)|endometrium(3)|large_intestine(4)|lung(9)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	25		all_lung(180;0.00177)		all cancers(107;1.16e-06)|GBM - Glioblastoma multiforme(94;0.000113)		GTGGCCACCACTGAAGTTGCT	0.458000													19	31					0	0	1	0	0
FBN2	2201	broad.mit.edu	37	5	127610357	127610357	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A5BR-01A-11D-A26M-08	TCGA-FD-A5BR-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afafc062-4c58-491a-8c4b-e714591ac2c2	2c6c386c-6fe4-4b77-ab2b-893aca19a3c6	g.chr5:127610357G>T	ENST00000508053.1	-	66	8587	c.7613C>A	c.(7612-7614)aCa>aAa	p.T2538K	FBN2_ENST00000262464.4_Missense_Mutation_p.T2538K			P35556	FBN2_HUMAN	fibrillin 2	2538	EGF-like 43; calcium-binding.				bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			NS(1)|autonomic_ganglia(1)|biliary_tract(1)|breast(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(37)|liver(1)|lung(89)|ovary(9)|pancreas(2)|prostate(6)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	197		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		ATGCTGCTTTGTTTGACATTC	0.458000													5	48					0.0215528	0.0220916	1	1	0
FLG	2312	broad.mit.edu	37	1	152284326	152284326	+	Silent	SNP	A	A	C			TCGA-FD-A5BR-01A-11D-A26M-08	TCGA-FD-A5BR-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afafc062-4c58-491a-8c4b-e714591ac2c2	2c6c386c-6fe4-4b77-ab2b-893aca19a3c6	g.chr1:152284326A>C	ENST00000368799.1	-	3	3071	c.3036T>G	c.(3034-3036)acT>acG	p.T1012T	FLG-AS1_ENST00000593011.1_RNA|FLG-AS1_ENST00000420707.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	1012	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CACCAGAGGAAGTCTCTGCGT	0.587000									Ichthyosis				162	338					0	0	1	0	0
NEB	4703	broad.mit.edu	37	2	152348933	152348933	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A5BR-01A-11D-A26M-08	TCGA-FD-A5BR-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afafc062-4c58-491a-8c4b-e714591ac2c2	2c6c386c-6fe4-4b77-ab2b-893aca19a3c6	g.chr2:152348933G>A	ENST00000427231.2	-	177	25043	c.24841C>T	c.(24841-24843)Cgg>Tgg	p.R8281W	NEB_ENST00000498015.2_5'UTR|RIF1_ENST00000457745.1_Intron|NEB_ENST00000603639.1_Missense_Mutation_p.R8281W|NEB_ENST00000172853.10_Missense_Mutation_p.R6425W|NEB_ENST00000397336.2_Missense_Mutation_p.R256W|NEB_ENST00000509223.2_Missense_Mutation_p.R194W|NEB_ENST00000409198.1_Missense_Mutation_p.R6425W|NEB_ENST00000397345.3_Missense_Mutation_p.R8281W|NEB_ENST00000604864.1_Missense_Mutation_p.R8281W	NM_001164507.1|NM_001271208.1	NP_001157979|NP_001258137.1	P20929	NEBU_HUMAN	nebulin	6593					muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			NS(5)|autonomic_ganglia(3)|breast(9)|central_nervous_system(5)|cervix(3)|endometrium(35)|kidney(16)|large_intestine(77)|liver(1)|lung(99)|ovary(9)|pancreas(3)|prostate(13)|skin(7)|stomach(8)|upper_aerodigestive_tract(6)|urinary_tract(2)	301				BRCA - Breast invasive adenocarcinoma(221;0.219)		TCCCTCACCCGTCTCATCTCG	0.473000													5	42					0	0	1	0	0
ADCY8	114	broad.mit.edu	37	8	131880114	131880114	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A5BR-01A-11D-A26M-08	TCGA-FD-A5BR-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afafc062-4c58-491a-8c4b-e714591ac2c2	2c6c386c-6fe4-4b77-ab2b-893aca19a3c6	g.chr8:131880114G>C	ENST00000286355.5	-	9	4280	c.2188C>G	c.(2188-2190)Caa>Gaa	p.Q730E	ADCY8_ENST00000377928.3_Intron	NM_001115.2	NP_001106.1	P40145	ADCY8_HUMAN	adenylate cyclase 8 (brain)	730					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|membrane fraction|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|metal ion binding			NS(1)|breast(4)|central_nervous_system(2)|cervix(1)|endometrium(10)|kidney(5)|large_intestine(21)|lung(67)|pancreas(1)|prostate(3)|skin(12)|upper_aerodigestive_tract(5)|urinary_tract(2)	134	Esophageal squamous(12;0.00693)|Ovarian(258;0.00707)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000538)			AGCAAACTTTGTATTGCCGTG	0.353000										HNSCC(32;0.087)			36	25					0	0	1	0	0
PC	5091	broad.mit.edu	37	11	66636366	66636366	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A5BR-01A-11D-A26M-08	TCGA-FD-A5BR-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afafc062-4c58-491a-8c4b-e714591ac2c2	2c6c386c-6fe4-4b77-ab2b-893aca19a3c6	g.chr11:66636366C>A	ENST00000393960.1	-	10	1254	c.973G>T	c.(973-975)Gtc>Ttc	p.V325F	PC_ENST00000355677.3_Missense_Mutation_p.V325F|PC_ENST00000524491.1_Missense_Mutation_p.V285F|PC_ENST00000393955.2_Missense_Mutation_p.V325F|PC_ENST00000393958.2_Missense_Mutation_p.V325F	NM_001040716.1	NP_001035806.1	P11498	PYC_HUMAN	pyruvate carboxylase	325	ATP-grasp.|Biotin carboxylation.				gluconeogenesis|lipid biosynthetic process	mitochondrial matrix	ATP binding|biotin binding|biotin carboxylase activity|metal ion binding|pyruvate carboxylase activity			cervix(1)|endometrium(3)|kidney(3)|large_intestine(9)|lung(12)|ovary(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	32		Melanoma(852;0.0525)		Lung(977;0.153)|LUSC - Lung squamous cell carcinoma(976;0.227)	Biotin(DB00121)|Pyruvic acid(DB00119)	CGGGAGTTGACCTCGATGAAG	0.662000													40	59					5.04308e-16	6.46145e-16	1	1	0
PRDM9	56979	broad.mit.edu	37	5	23509685	23509685	+	Missense_Mutation	SNP	A	A	C			TCGA-FD-A5BR-01A-11D-A26M-08	TCGA-FD-A5BR-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afafc062-4c58-491a-8c4b-e714591ac2c2	2c6c386c-6fe4-4b77-ab2b-893aca19a3c6	g.chr5:23509685A>C	ENST00000296682.3	+	3	358	c.176A>C	c.(175-177)aAt>aCt	p.N59T		NM_020227.2	NP_064612.2	Q9NQV7	PRDM9_HUMAN	PR domain containing 9	59	KRAB-related.				meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleoplasm	histone-lysine N-methyltransferase activity|nucleic acid binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(3)|endometrium(15)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(27)|lung(87)|ovary(6)|pancreas(2)|prostate(4)|skin(10)|upper_aerodigestive_tract(11)	172						AGGAACTATAATGCACTGATT	0.433000										HNSCC(3;0.000094)			62	87					0	0	1	0	0
LRIG1	26018	broad.mit.edu	37	3	66433576	66433576	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A5BR-01A-11D-A26M-08	TCGA-FD-A5BR-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afafc062-4c58-491a-8c4b-e714591ac2c2	2c6c386c-6fe4-4b77-ab2b-893aca19a3c6	g.chr3:66433576G>A	ENST00000383703.3	-	16	2855	c.2252C>T	c.(2251-2253)gCt>gTt	p.A751V	SLC25A26_ENST00000536651.1_Intron|LRIG1_ENST00000273261.3_Missense_Mutation_p.A774V|LRIG1_ENST00000496559.2_5'UTR			Q96JA1	LRIG1_HUMAN	leucine-rich repeats and immunoglobulin-like domains 1	774	Ig-like C2-type 3.					integral to membrane				NS(2)|breast(2)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(12)|ovary(3)|prostate(1)|skin(4)|stomach(4)|urinary_tract(1)	42		Lung NSC(201;0.0101)		BRCA - Breast invasive adenocarcinoma(55;0.00047)		CTGGCTGTGAGCTCGCTCCGT	0.612000													45	126					0	0	1	0	0
LGALS16	148003	broad.mit.edu	37	19	40148588	40148588	+	Silent	SNP	C	C	T			TCGA-FD-A5BR-01A-11D-A26M-08	TCGA-FD-A5BR-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afafc062-4c58-491a-8c4b-e714591ac2c2	2c6c386c-6fe4-4b77-ab2b-893aca19a3c6	g.chr19:40148588C>T	ENST00000392051.3	+	2	149	c.81C>T	c.(79-81)atC>atT	p.I27I		NM_001190441.1	NP_001177370.1	A8MUM7	A8MUM7_HUMAN	lectin, galactoside-binding, soluble, 16	27							sugar binding										GGACACTGATCGACTCTTCTA	0.468000													17	33					0	0	1	0	0
UNC13C	440279	broad.mit.edu	37	15	54527298	54527298	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FD-A5BR-01A-11D-A26M-08	TCGA-FD-A5BR-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afafc062-4c58-491a-8c4b-e714591ac2c2	2c6c386c-6fe4-4b77-ab2b-893aca19a3c6	g.chr15:54527298C>T	ENST00000545554.1	+	4	3142	c.3142C>T	c.(3142-3144)Cga>Tga	p.R1048*	UNC13C_ENST00000260323.11_Nonsense_Mutation_p.R1048*|UNC13C_ENST00000537900.1_Nonsense_Mutation_p.R1048*			Q8NB66	UN13C_HUMAN	unc-13 homolog C (C. elegans)	1048					exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			breast(3)|endometrium(5)|kidney(5)|large_intestine(20)|lung(70)|ovary(6)|pancreas(2)|prostate(2)|upper_aerodigestive_tract(4)|urinary_tract(4)	121				GBM - Glioblastoma multiforme(80;0.0789)|all cancers(107;0.124)		GCCTATTGTCCGAGATGTGGT	0.383000													6	28					0	0	1	0	0
CPZ	8532	broad.mit.edu	37	4	8608502	8608502	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A5BR-01A-11D-A26M-08	TCGA-FD-A5BR-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afafc062-4c58-491a-8c4b-e714591ac2c2	2c6c386c-6fe4-4b77-ab2b-893aca19a3c6	g.chr4:8608502C>A	ENST00000382480.2	+	6	1334	c.534C>A	c.(532-534)aaC>aaA	p.N178K	CPZ_ENST00000360986.4_Missense_Mutation_p.N315K|CPZ_ENST00000429646.2_5'UTR|CPZ_ENST00000315782.6_Missense_Mutation_p.N304K	NM_001014448.2	NP_001014448	Q66K79	CBPZ_HUMAN	carboxypeptidase Z	315					proteolysis|Wnt receptor signaling pathway	proteinaceous extracellular matrix	metallocarboxypeptidase activity|zinc ion binding			cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(23)|ovary(3)|pancreas(1)|skin(1)|stomach(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	46						GGAGGCAGAACGCGCAGAACC	0.652000													19	63					5.03518e-11	6.25583e-11	1	1	0
PIWIL2	55124	broad.mit.edu	37	8	22137054	22137054	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A5BR-01A-11D-A26M-08	TCGA-FD-A5BR-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afafc062-4c58-491a-8c4b-e714591ac2c2	2c6c386c-6fe4-4b77-ab2b-893aca19a3c6	g.chr8:22137054G>A	ENST00000356766.6	+	2	303	c.155G>A	c.(154-156)gGa>gAa	p.G52E	PIWIL2_ENST00000521356.1_Missense_Mutation_p.G52E|PIWIL2_ENST00000454009.2_Missense_Mutation_p.G52E	NM_018068.3	NP_060538.2	Q8TC59	PIWL2_HUMAN	piwi-like RNA-mediated gene silencing 2	52					DNA methylation involved in gamete generation|gene silencing by RNA|germ-line stem cell maintenance|multicellular organismal development|oogenesis|piRNA metabolic process|positive regulation of translation|RNA 5'-end processing|spermatogenesis	chromatoid body|pi-body	piRNA binding			NS(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(14)|lung(14)|prostate(4)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)	46				Colorectal(74;0.018)|COAD - Colon adenocarcinoma(73;0.0707)		CATGTATTTGGAAAGCCAGAG	0.572000													28	65					0	0	1	0	0
MYO9B	4650	broad.mit.edu	37	19	17316122	17316122	+	Missense_Mutation	SNP	T	T	C			TCGA-FD-A5BR-01A-11D-A26M-08	TCGA-FD-A5BR-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afafc062-4c58-491a-8c4b-e714591ac2c2	2c6c386c-6fe4-4b77-ab2b-893aca19a3c6	g.chr19:17316122T>C	ENST00000595618.1	+	31	5193	c.5041T>C	c.(5041-5043)Tgc>Cgc	p.C1681R	MYO9B_ENST00000397274.2_Missense_Mutation_p.C1681R|MYO9B_ENST00000594824.1_Missense_Mutation_p.C1681R	NM_001130065.1|NM_004145.3	NP_001123537.1|NP_004136.2	Q13459	MYO9B_HUMAN	myosin IXB	1681	Tail.				actin filament-based movement	cell cortex|cytosol|filamentous actin|myosin complex|perinuclear region of cytoplasm	actin binding|ADP binding|ATP binding|ATPase activity|calmodulin binding|metal ion binding|microfilament motor activity|Rho GTPase activator activity			breast(3)|endometrium(9)|kidney(2)|large_intestine(1)|lung(19)|soft_tissue(1)|urinary_tract(4)	39						TCAGAGCCACTGCTCCTACAC	0.572000													20	58					0	0	1	0	0
MATN3	4148	broad.mit.edu	37	2	20197015	20197015	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A5BR-01A-11D-A26M-08	TCGA-FD-A5BR-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afafc062-4c58-491a-8c4b-e714591ac2c2	2c6c386c-6fe4-4b77-ab2b-893aca19a3c6	g.chr2:20197015C>T	ENST00000407540.3	-	6	1236	c.1174G>A	c.(1174-1176)Gac>Aac	p.D392N	AC079145.4_ENST00000416575.1_RNA|MATN3_ENST00000421259.2_Missense_Mutation_p.D350N	NM_002381.4	NP_002372.1	O15232	MATN3_HUMAN	matrilin 3	392	EGF-like 4.				skeletal system development	proteinaceous extracellular matrix	extracellular matrix structural constituent|protein binding			central_nervous_system(1)|endometrium(2)|large_intestine(3)|lung(6)|skin(1)	13	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GCACACTTGTCACGGACTGAC	0.468000													3	12					0	0	1	0	0
BMP6	654	broad.mit.edu	37	6	7727541	7727541	+	Missense_Mutation	SNP	A	A	T			TCGA-FD-A5BR-01A-11D-A26M-08	TCGA-FD-A5BR-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afafc062-4c58-491a-8c4b-e714591ac2c2	2c6c386c-6fe4-4b77-ab2b-893aca19a3c6	g.chr6:7727541A>T	ENST00000283147.6	+	1	512	c.353A>T	c.(352-354)cAg>cTg	p.Q118L		NM_001718.4	NP_001709.1	P22004	BMP6_HUMAN	bone morphogenetic protein 6	118					BMP signaling pathway|cartilage development|growth|immune response|positive regulation of aldosterone biosynthetic process|positive regulation of bone mineralization|positive regulation of osteoblast differentiation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of transcription from RNA polymerase II promoter|SMAD protein signal transduction	extracellular space	BMP receptor binding|cytokine activity|growth factor activity|protein heterodimerization activity	p.Q118L(1)		breast(1)|endometrium(3)|kidney(2)|large_intestine(9)|lung(6)|ovary(1)|prostate(1)	23	Ovarian(93;0.0721)					cagcagcagcagcTGCCTCGC	0.731000													3	22					0	0	1	0	0
ST6GAL2	84620	broad.mit.edu	37	2	107459724	107459724	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A5BR-01A-11D-A26M-08	TCGA-FD-A5BR-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afafc062-4c58-491a-8c4b-e714591ac2c2	2c6c386c-6fe4-4b77-ab2b-893aca19a3c6	g.chr2:107459724C>T	ENST00000409382.3	-	2	1320	c.710G>A	c.(709-711)cGc>cAc	p.R237H	ST6GAL2_ENST00000361686.4_Missense_Mutation_p.R237H|ST6GAL2_ENST00000409087.3_Missense_Mutation_p.R237H	NM_001142351.1	NP_001135823.1	Q96JF0	SIAT2_HUMAN	ST6 beta-galactosamide alpha-2,6-sialyltranferase 2	237					growth|multicellular organismal development|oligosaccharide metabolic process|protein glycosylation	Golgi cisterna membrane|integral to Golgi membrane	beta-galactoside alpha-2,6-sialyltransferase activity	p.R237L(1)		autonomic_ganglia(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(8)|liver(1)|lung(30)|ovary(5)|pancreas(6)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	65						CCCGCGGAAGCGCACCCCGTG	0.687000													6	8					0	0	1	0	0
SACS	26278	broad.mit.edu	37	13	23907631	23907631	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A5BR-01A-11D-A26M-08	TCGA-FD-A5BR-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afafc062-4c58-491a-8c4b-e714591ac2c2	2c6c386c-6fe4-4b77-ab2b-893aca19a3c6	g.chr13:23907631G>T	ENST00000382298.3	-	10	10972	c.10384C>A	c.(10384-10386)Cta>Ata	p.L3462I	SACS_ENST00000402364.1_Missense_Mutation_p.L2712I|SACS_ENST00000382292.3_Missense_Mutation_p.L3462I	NM_014363.4	NP_055178.3	Q9NZJ4	SACS_HUMAN	spastic ataxia of Charlevoix-Saguenay (sacsin)	3462					cell death|negative regulation of inclusion body assembly|protein folding	axon|cell body fiber|dendrite|mitochondrion|nucleus	ATP binding|chaperone binding|Hsp70 protein binding|proteasome binding			NS(1)|biliary_tract(1)|breast(3)|central_nervous_system(2)|endometrium(22)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(54)|lung(49)|ovary(7)|pancreas(1)|prostate(4)|skin(10)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(11)	189		all_cancers(29;1.51e-22)|all_epithelial(30;7.82e-19)|all_lung(29;4.71e-18)|Lung SC(185;0.0225)|Breast(139;0.128)		all cancers(112;0.00197)|Epithelial(112;0.00854)|OV - Ovarian serous cystadenocarcinoma(117;0.0298)|Lung(94;0.189)		ACCTCATATAGTTCTTTTAAG	0.338000													4	34					1	1	1	1	0
GRIP1	23426	broad.mit.edu	37	12	66771061	66771061	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A5BR-01A-11D-A26M-08	TCGA-FD-A5BR-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afafc062-4c58-491a-8c4b-e714591ac2c2	2c6c386c-6fe4-4b77-ab2b-893aca19a3c6	g.chr12:66771061C>G	ENST00000359742.4	-	21	2866	c.2626G>C	c.(2626-2628)Gca>Cca	p.A876P	GRIP1_ENST00000398016.3_Missense_Mutation_p.A824P|GRIP1_ENST00000286445.7_Missense_Mutation_p.A876P			Q9Y3R0	GRIP1_HUMAN	glutamate receptor interacting protein 1	876					androgen receptor signaling pathway|intracellular signal transduction|positive regulation of transcription, DNA-dependent|synaptic transmission	cell junction|cytoplasmic membrane-bounded vesicle|cytosol|endoplasmic reticulum|postsynaptic membrane	androgen receptor binding|beta-catenin binding|protein C-terminus binding|receptor signaling complex scaffold activity|transcription coactivator activity			NS(3)|breast(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(10)|lung(19)|ovary(2)|prostate(2)|skin(1)	50			GBM - Glioblastoma multiforme(2;0.00069)	GBM - Glioblastoma multiforme(28;0.0933)		GCAGCCCCTGCAAAACTGTTG	0.488000													17	127					0	0	1	0	0
DOCK2	1794	broad.mit.edu	37	5	169139183	169139183	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A5BR-01A-11D-A26M-08	TCGA-FD-A5BR-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afafc062-4c58-491a-8c4b-e714591ac2c2	2c6c386c-6fe4-4b77-ab2b-893aca19a3c6	g.chr5:169139183G>T	ENST00000256935.8	+	17	1695	c.1615G>T	c.(1615-1617)Ggg>Tgg	p.G539W	DOCK2_ENST00000520908.1_Intron|DOCK2_ENST00000540750.1_Intron	NM_004946.2	NP_004937.1	Q92608	DOCK2_HUMAN	dedicator of cytokinesis 2	539	DHR-1.				actin cytoskeleton organization|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|endomembrane system|membrane	electron carrier activity|GTP binding|GTPase binding|heme binding|Rac guanyl-nucleotide exchange factor activity|T cell receptor binding			NS(2)|breast(5)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(42)|liver(2)|lung(63)|ovary(5)|pancreas(3)|prostate(7)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)	160	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			GAAAGAAGATGGGACTACTCT	0.448000													7	58					0.000274275	0.000295928	1	1	0
SLC6A1	6529	broad.mit.edu	37	3	11061975	11061975	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A5BR-01A-11D-A26M-08	TCGA-FD-A5BR-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afafc062-4c58-491a-8c4b-e714591ac2c2	2c6c386c-6fe4-4b77-ab2b-893aca19a3c6	g.chr3:11061975C>T	ENST00000287766.4	+	6	969	c.548C>T	c.(547-549)aCc>aTc	p.T183I	SLC6A1_ENST00000536032.1_Missense_Mutation_p.T5I	NM_003042.3	NP_003033.3	P30531	SC6A1_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 1	183					neurotransmitter secretion	integral to plasma membrane	gamma-aminobutyric acid:sodium symporter activity|neurotransmitter:sodium symporter activity			breast(1)|endometrium(2)|large_intestine(6)|lung(6)|ovary(1)|prostate(4)|skin(5)|upper_aerodigestive_tract(1)	26		Ovarian(110;0.0392)		OV - Ovarian serous cystadenocarcinoma(96;0.00099)	Cocaine(DB00907)|Tiagabine(DB00906)	GTCAACACTACCAACATGACC	0.587000													5	16					0	0	1	0	0
ATP10A	57194	broad.mit.edu	37	15	25959156	25959156	+	Missense_Mutation	SNP	T	T	A			TCGA-FD-A5BR-01A-11D-A26M-08	TCGA-FD-A5BR-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afafc062-4c58-491a-8c4b-e714591ac2c2	2c6c386c-6fe4-4b77-ab2b-893aca19a3c6	g.chr15:25959156T>A	ENST00000356865.6	-	10	2120	c.2009A>T	c.(2008-2010)tAc>tTc	p.Y670F		NM_024490.3	NP_077816.1	O60312	AT10A_HUMAN	ATPase, class V, type 10A	670					ATP biosynthetic process|regulation of cell shape	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			NS(1)|breast(2)|endometrium(8)|kidney(2)|large_intestine(33)|liver(1)|lung(41)|ovary(3)|pancreas(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(2)	103		all_cancers(20;5.16e-25)|all_lung(180;1.51e-14)|Acute lymphoblastic leukemia(1;2.53e-05)|all_hematologic(1;0.000267)|Breast(32;0.00125)		all cancers(64;9.48e-07)|Epithelial(43;1.69e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0252)|Lung(196;0.244)		CTGGCTGCTGTAGCCGTTGCT	0.687000													16	38					0	0	1	0	0
GPR116	221395	broad.mit.edu	37	6	46826155	46826155	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A5BR-01A-11D-A26M-08	TCGA-FD-A5BR-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afafc062-4c58-491a-8c4b-e714591ac2c2	2c6c386c-6fe4-4b77-ab2b-893aca19a3c6	g.chr6:46826155C>A	ENST00000283296.7	-	17	3773	c.3485G>T	c.(3484-3486)tGt>tTt	p.C1162F	GPR116_ENST00000545669.1_Missense_Mutation_p.C591F|GPR116_ENST00000265417.7_Missense_Mutation_p.C1162F|GPR116_ENST00000362015.4_Missense_Mutation_p.C1162F|GPR116_ENST00000456426.2_Missense_Mutation_p.C1020F	NM_001098518.1	NP_001091988.1	Q8IZF2	GP116_HUMAN	G protein-coupled receptor 116	1162					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(2)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(14)|lung(21)|ovary(1)|pancreas(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	59			Lung(136;0.192)			GTTGAGCCAACAGACATTCTT	0.557000													13	42					2.27111e-07	2.61072e-07	1	1	0
ETV1	2115	broad.mit.edu	37	7	13935606	13935606	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A5BR-01A-11D-A26M-08	TCGA-FD-A5BR-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afafc062-4c58-491a-8c4b-e714591ac2c2	2c6c386c-6fe4-4b77-ab2b-893aca19a3c6	g.chr7:13935606C>T	ENST00000343495.5	-	13	2003	c.1265G>A	c.(1264-1266)cGt>cAt	p.R422H	ETV1_ENST00000430479.1_Missense_Mutation_p.R440H|ETV1_ENST00000405192.2_Missense_Mutation_p.R417H|ETV1_ENST00000405218.2_Missense_Mutation_p.R440H|ETV1_ENST00000399357.3_Missense_Mutation_p.R337H|ETV1_ENST00000403685.1_Missense_Mutation_p.R422H|ETV1_ENST00000405358.4_Missense_Mutation_p.R454H|ETV1_ENST00000242066.5_Missense_Mutation_p.R422H|ETV1_ENST00000420159.2_Missense_Mutation_p.R382H|ETV1_ENST00000403527.1_Missense_Mutation_p.R400H			P50549	ETV1_HUMAN	ets variant 1	440					transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		TMPRSS2/ETV1(34)|ACSL3_ENST00000357430/ETV1(2)|EWSR1/ETV1(7)|KLK2/ETV1(3)|SLC45A3/ETV1(3)|HNRNPA2B1/ETV1(8)	breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(9)|lung(15)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	31						GTTGATGTGACGTTCCATGTC	0.517000			T	"""EWSR1, TMPRSS2, SLC45A3, C15orf21, HNRNPA2B1. ACSL3"""	"""Ewing sarcoma, prostate"""								9	19					0	0	1	0	0
APOL2	23780	broad.mit.edu	37	22	36624228	36624228	+	Missense_Mutation	SNP	T	T	C			TCGA-FD-A5BR-01A-11D-A26M-08	TCGA-FD-A5BR-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afafc062-4c58-491a-8c4b-e714591ac2c2	2c6c386c-6fe4-4b77-ab2b-893aca19a3c6	g.chr22:36624228T>C	ENST00000249066.6	-	6	712	c.236A>G	c.(235-237)cAg>cGg	p.Q79R	APOL2_ENST00000358502.5_Missense_Mutation_p.Q79R|APOL2_ENST00000451256.2_Missense_Mutation_p.Q191R	NM_145637.1	NP_663612.1	Q9BQE5	APOL2_HUMAN	apolipoprotein L, 2	79					acute-phase response|cholesterol metabolic process|lipid transport|lipoprotein metabolic process|maternal process involved in female pregnancy|multicellular organismal development	endoplasmic reticulum membrane|extracellular region	high-density lipoprotein particle binding|lipid binding|receptor binding			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(1)|skin(1)|urinary_tract(2)	9						CAAAAACCACTGCCTGTGCTG	0.512000													33	86					0	0	1	0	0
MIDN	90007	broad.mit.edu	37	19	1257172	1257172	+	Silent	SNP	C	C	T			TCGA-FD-A5BR-01A-11D-A26M-08	TCGA-FD-A5BR-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afafc062-4c58-491a-8c4b-e714591ac2c2	2c6c386c-6fe4-4b77-ab2b-893aca19a3c6	g.chr19:1257172C>T	ENST00000300952.2	+	8	1823	c.1308C>T	c.(1306-1308)ggC>ggT	p.G436G	MIDN_ENST00000591446.2_Silent_p.G436G	NM_177401.4	NP_796375.3	Q504T8	MIDN_HUMAN	midnolin	436						nucleolus				NS(1)|endometrium(3)|kidney(1)|lung(6)|prostate(1)|upper_aerodigestive_tract(1)	13		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;7.93e-06)|all_lung(49;1.25e-05)|Breast(49;0.000172)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GGGGCGGCGGCAGCCCCAGCG	0.687000													27	68					0	0	1	0	0
C1orf173	127254	broad.mit.edu	37	1	75072402	75072402	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A5BR-01A-11D-A26M-08	TCGA-FD-A5BR-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afafc062-4c58-491a-8c4b-e714591ac2c2	2c6c386c-6fe4-4b77-ab2b-893aca19a3c6	g.chr1:75072402C>A	ENST00000326665.5	-	10	1590	c.1372G>T	c.(1372-1374)Gct>Tct	p.A458S	RP4-612J11.1_ENST00000416017.1_RNA|C1orf173_ENST00000420661.2_Missense_Mutation_p.A261S	NM_001002912.4	NP_001002912.4	Q5RHP9	CA173_HUMAN	chromosome 1 open reading frame 173	458	Glu-rich.									NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(23)|lung(123)|ovary(3)|prostate(10)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)	184						ATTTCTTGAGCTGAAAATTTG	0.418000													15	88					2.32078e-09	2.77142e-09	1	1	0
UTP20	27340	broad.mit.edu	37	12	101760367	101760367	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A5BR-01A-11D-A26M-08	TCGA-FD-A5BR-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afafc062-4c58-491a-8c4b-e714591ac2c2	2c6c386c-6fe4-4b77-ab2b-893aca19a3c6	g.chr12:101760367C>G	ENST00000261637.4	+	47	6331	c.6157C>G	c.(6157-6159)Cta>Gta	p.L2053V		NM_014503.2	NP_055318.2	O75691	UTP20_HUMAN	UTP20, small subunit (SSU) processome component, homolog (yeast)	2053					endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|negative regulation of cell proliferation	90S preribosome|cytoplasm|nucleolus|nucleoplasm|preribosome, small subunit precursor|small-subunit processome	protein binding			NS(3)|biliary_tract(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(26)|lung(30)|ovary(2)|prostate(3)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	88						AGATCCACGTCTACCACCCCA	0.502000													34	111					0	0	1	0	0
PEG3	5178	broad.mit.edu	37	19	57325887	57325887	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A5BR-01A-11D-A26M-08	TCGA-FD-A5BR-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afafc062-4c58-491a-8c4b-e714591ac2c2	2c6c386c-6fe4-4b77-ab2b-893aca19a3c6	g.chr19:57325887G>A	ENST00000326441.9	-	10	4286	c.3923C>T	c.(3922-3924)cCc>cTc	p.P1308L	PEG3_ENST00000593695.1_Missense_Mutation_p.P1182L|PEG3_ENST00000598410.1_Missense_Mutation_p.P1184L|ZIM2_ENST00000601070.1_Intron|ZIM2_ENST00000221722.5_Intron|ZIM2_ENST00000391708.3_Intron|ZIM2_ENST00000593711.1_Intron|ZIM2_ENST00000599935.1_Intron|PEG3_ENST00000423103.2_Missense_Mutation_p.P1308L	NM_006210.2	NP_006201.1	Q9GZU2	PEG3_HUMAN	paternally expressed 3	1308					apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|biliary_tract(4)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(27)|lung(84)|ovary(8)|pancreas(5)|prostate(6)|skin(8)|stomach(2)|upper_aerodigestive_tract(6)	170		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)		GTACTCATAGGGCTCATTCTT	0.448000													4	48					0	0	1	0	0
TBL3	10607	broad.mit.edu	37	16	2025614	2025614	+	Missense_Mutation	SNP	A	A	C			TCGA-FD-A5BR-01A-11D-A26M-08	TCGA-FD-A5BR-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afafc062-4c58-491a-8c4b-e714591ac2c2	2c6c386c-6fe4-4b77-ab2b-893aca19a3c6	g.chr16:2025614A>C	ENST00000568546.1	+	10	1018	c.890A>C	c.(889-891)cAc>cCc	p.H297P		NM_006453.2	NP_006444.2	Q12788	TBL3_HUMAN	transducin (beta)-like 3	297					G-protein signaling, coupled to cGMP nucleotide second messenger|rRNA processing	nucleolus|small-subunit processome	receptor signaling protein activity			breast(1)|endometrium(2)|kidney(4)|lung(7)|ovary(1)|prostate(2)|skin(1)	18						GAGCTGACCCACTGCACCCTG	0.692000													4	27					0	0	1	0	0
MAML3	55534	broad.mit.edu	37	4	140811108	140811108	+	Silent	SNP	C	C	T			TCGA-FD-A5BR-01A-11D-A26M-08	TCGA-FD-A5BR-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afafc062-4c58-491a-8c4b-e714591ac2c2	2c6c386c-6fe4-4b77-ab2b-893aca19a3c6	g.chr4:140811108C>T	ENST00000509479.2	-	2	2338	c.1482G>A	c.(1480-1482)caG>caA	p.Q494Q	MAML3_ENST00000398940.1_Silent_p.Q33Q|MAML3_ENST00000327122.5_Silent_p.Q338Q	NM_018717.4	NP_061187	Q96JK9	MAML3_HUMAN	mastermind-like 3 (Drosophila)	494	Gln-rich.				Notch signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear speck	transcription coactivator activity			breast(1)|endometrium(7)|kidney(2)|large_intestine(1)|lung(9)|ovary(1)|prostate(2)|urinary_tract(2)	25	all_hematologic(180;0.162)					gctgctgctgctgctgctgct	0.537000													4	38					0	0	1	0	0
CIT	11113	broad.mit.edu	37	12	120139706	120139706	+	Missense_Mutation	SNP	T	T	C			TCGA-FD-A5BR-01A-11D-A26M-08	TCGA-FD-A5BR-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afafc062-4c58-491a-8c4b-e714591ac2c2	2c6c386c-6fe4-4b77-ab2b-893aca19a3c6	g.chr12:120139706T>C	ENST00000392521.2	-	42	5417	c.5362A>G	c.(5362-5364)Att>Gtt	p.I1788V	CIT_ENST00000537607.1_5'UTR|CIT_ENST00000261833.7_Missense_Mutation_p.I1746V	NM_001206999.1	NP_001193928.1	O14578	CTRO_HUMAN	citron (rho-interacting, serine/threonine kinase 21)	1746	CNH.				intracellular signal transduction		ATP binding|metal ion binding|protein serine/threonine kinase activity|SH3 domain binding|small GTPase regulator activity			breast(6)|endometrium(9)|kidney(4)|large_intestine(15)|liver(1)|lung(29)|ovary(7)|prostate(4)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(6)	86	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)	Myeloproliferative disorder(1001;0.0255)		BRCA - Breast invasive adenocarcinoma(302;0.211)		TTGGTTCCAATGAGGATACTG	0.512000													44	88					0	0	1	0	0
RAB31	11031	broad.mit.edu	37	18	9859240	9859240	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A5BR-01A-11D-A26M-08	TCGA-FD-A5BR-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afafc062-4c58-491a-8c4b-e714591ac2c2	2c6c386c-6fe4-4b77-ab2b-893aca19a3c6	g.chr18:9859240C>T	ENST00000578921.1	+	7	747	c.506C>T	c.(505-507)cCc>cTc	p.P169L	RAB31_ENST00000577284.1_3'UTR	NM_006868.3	NP_006859.2	Q13636	RAB31_HUMAN	RAB31, member RAS oncogene family	168					protein transport|small GTPase mediated signal transduction	plasma membrane	GTP binding|GTPase activity			breast(2)|endometrium(2)|large_intestine(2)|lung(3)|skin(1)	10						CAGATCCCACCCTTGGACCCC	0.542000													30	47					0	0	1	0	0
SLC5A9	200010	broad.mit.edu	37	1	48708224	48708224	+	Silent	SNP	C	C	T	rs147141681		TCGA-FD-A5BR-01A-11D-A26M-08	TCGA-FD-A5BR-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afafc062-4c58-491a-8c4b-e714591ac2c2	2c6c386c-6fe4-4b77-ab2b-893aca19a3c6	g.chr1:48708224C>T	ENST00000236495.5	+	14	1898	c.1848C>T	c.(1846-1848)gcC>gcT	p.A616A	SLC5A9_ENST00000438567.2_Silent_p.A591A|SLC5A9_ENST00000471020.1_3'UTR|SLC5A9_ENST00000533824.1_Silent_p.A612A	NM_001135181.1	NP_001128653.1	Q2M3M2	SC5A9_HUMAN	solute carrier family 5 (sodium/sugar cotransporter), member 9	591						integral to membrane|plasma membrane	low-affinity glucose:sodium symporter activity			breast(1)|endometrium(3)|large_intestine(4)|liver(2)|lung(11)|ovary(3)|prostate(1)|urinary_tract(1)	26						AGAGGCCAGCCGGGGAGTGCC	0.652000													10	60					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	8976428	8976428	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A5BR-01A-11D-A26M-08	TCGA-FD-A5BR-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afafc062-4c58-491a-8c4b-e714591ac2c2	2c6c386c-6fe4-4b77-ab2b-893aca19a3c6	g.chr19:8976428C>G	ENST00000397910.4	-	75	42603	c.42400G>C	c.(42400-42402)Gag>Cag	p.E14134Q	MUC16_ENST00000596956.1_Intron|MUC16_ENST00000380951.5_Missense_Mutation_p.E775Q	NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	14165	SEA 14.			Missing (in Ref. 3; AAK74120).	cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding	p.E14134Q(1)		NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						CCATCCTTCTCAGGCCTGGGG	0.617000													6	26					0	0	1	0	0
ATAD3C	219293	broad.mit.edu	37	1	1390875	1390875	+	Silent	SNP	C	C	T	rs1781147	by1000genomes	TCGA-FD-A5BR-01A-11D-A26M-08	TCGA-FD-A5BR-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afafc062-4c58-491a-8c4b-e714591ac2c2	2c6c386c-6fe4-4b77-ab2b-893aca19a3c6	g.chr1:1390875C>T	ENST00000378785.2	+	5	1409	c.414C>T	c.(412-414)gaC>gaT	p.D138D		NM_001039211.2	NP_001034300.2	Q5T2N8	ATD3C_HUMAN	ATPase family, AAA domain containing 3C	138							ATP binding|nucleoside-triphosphatase activity			autonomic_ganglia(1)|endometrium(1)|kidney(1)|lung(4)	7	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;1.79e-36)|OV - Ovarian serous cystadenocarcinoma(86;3.94e-22)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.00461)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.145)		GACCCCAGGACGTGCTGGAGG	0.677000													3	35					0	0	1	0	0
RASAL3	64926	broad.mit.edu	37	19	15564277	15564277	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A5BR-01A-11D-A26M-08	TCGA-FD-A5BR-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afafc062-4c58-491a-8c4b-e714591ac2c2	2c6c386c-6fe4-4b77-ab2b-893aca19a3c6	g.chr19:15564277C>G	ENST00000343625.7	-	15	2396	c.2311G>C	c.(2311-2313)Gcc>Ccc	p.A771P		NM_022904.1	NP_075055.1	Q86YV0	RASL3_HUMAN	RAS protein activator like 3						negative regulation of Ras protein signal transduction|signal transduction	cytoplasm|intrinsic to internal side of plasma membrane	Ras GTPase activator activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(10)|skin(1)	18						TCCCGGGGGGCCAGGAAGCCG	0.682000													3	10					0	0	1	0	0
TG	7038	broad.mit.edu	37	8	134034365	134034365	+	Silent	SNP	C	C	A	rs144875913		TCGA-FD-A5BR-01A-11D-A26M-08	TCGA-FD-A5BR-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afafc062-4c58-491a-8c4b-e714591ac2c2	2c6c386c-6fe4-4b77-ab2b-893aca19a3c6	g.chr8:134034365C>A	ENST00000220616.4	+	40	7046	c.7006C>A	c.(7006-7008)Cga>Aga	p.R2336R	TG_ENST00000377869.1_Silent_p.R2279R|TG_ENST00000519543.1_Silent_p.R469R|TG_ENST00000542445.1_Silent_p.R706R	NM_003235.4	NP_003226.4	P01266	THYG_HUMAN	thyroglobulin	2336			R -> Q (in TDH3).		hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			NS(1)|breast(11)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(34)|liver(2)|lung(59)|ovary(9)|pancreas(2)|prostate(6)|skin(7)|stomach(4)|upper_aerodigestive_tract(4)|urinary_tract(8)	168	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		TGCCAGCTACCGAGTGGGTGT	0.607000													9	199					4.68919e-08	5.49305e-08	1	1	0
TMEM132B	114795	broad.mit.edu	37	12	126135303	126135303	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A5BR-01A-11D-A26M-08	TCGA-FD-A5BR-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afafc062-4c58-491a-8c4b-e714591ac2c2	2c6c386c-6fe4-4b77-ab2b-893aca19a3c6	g.chr12:126135303C>A	ENST00000299308.3	+	7	1711	c.1703C>A	c.(1702-1704)gCc>gAc	p.A568D	TMEM132B_ENST00000535886.1_Missense_Mutation_p.A80D	NM_052907.2	NP_443139.2	Q14DG7	T132B_HUMAN	transmembrane protein 132B	568						integral to membrane				NS(1)|breast(9)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(11)|liver(1)|lung(45)|ovary(5)|pancreas(1)|prostate(4)|skin(15)|upper_aerodigestive_tract(3)|urinary_tract(1)	107	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000423)|Epithelial(86;0.00394)|all cancers(50;0.0362)		TACCAGCACGCCACAGTGCGT	0.582000													19	37					1.01871e-10	1.25302e-10	1	1	0
DISP1	84976	broad.mit.edu	37	1	223178584	223178584	+	Missense_Mutation	SNP	A	A	G			TCGA-FD-A5BR-01A-11D-A26M-08	TCGA-FD-A5BR-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afafc062-4c58-491a-8c4b-e714591ac2c2	2c6c386c-6fe4-4b77-ab2b-893aca19a3c6	g.chr1:223178584A>G	ENST00000284476.6	+	8	4009	c.3845A>G	c.(3844-3846)tAt>tGt	p.Y1282C		NM_032890.3	NP_116279.2	Q96F81	DISP1_HUMAN	dispatched homolog 1 (Drosophila)	1282					diaphragm development|protein homotrimerization|regulation of protein secretion|smoothened signaling pathway	basolateral plasma membrane|integral to membrane	hedgehog receptor activity|peptide transporter activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(3)|large_intestine(20)|lung(25)|prostate(4)|skin(1)|stomach(1)|urinary_tract(5)	69				GBM - Glioblastoma multiforme(131;0.102)		CACTTGAACTATGGCCCACAC	0.532000													11	117					0	0	1	0	0
MDGA2	161357	broad.mit.edu	37	14	47504364	47504364	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A5BR-01A-11D-A26M-08	TCGA-FD-A5BR-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afafc062-4c58-491a-8c4b-e714591ac2c2	2c6c386c-6fe4-4b77-ab2b-893aca19a3c6	g.chr14:47504364C>A	ENST00000426342.1	-	8	1521	c.775G>T	c.(775-777)Gat>Tat	p.D259Y	MDGA2_ENST00000399232.2_Missense_Mutation_p.D488Y|MDGA2_ENST00000357362.3_Missense_Mutation_p.D259Y|MDGA2_ENST00000439988.3_Missense_Mutation_p.D557Y	NM_182830.3	NP_878250.2	Q7Z553	MDGA2_HUMAN	MAM domain containing glycosylphosphatidylinositol anchor 2	488	Ig-like 3.				spinal cord motor neuron differentiation	anchored to membrane|plasma membrane				breast(3)|endometrium(4)|kidney(2)|large_intestine(14)|lung(41)|ovary(4)|pancreas(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(5)	76						ATTGATCCATCAGGCATTGCA	0.418000													15	82					1.15088e-07	1.33545e-07	1	1	0
ZNF768	79724	broad.mit.edu	37	16	30535972	30535972	+	Missense_Mutation	SNP	A	A	G			TCGA-FD-A5BR-01A-11D-A26M-08	TCGA-FD-A5BR-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afafc062-4c58-491a-8c4b-e714591ac2c2	2c6c386c-6fe4-4b77-ab2b-893aca19a3c6	g.chr16:30535972A>G	ENST00000380412.5	-	2	1664	c.1489T>C	c.(1489-1491)Tcc>Ccc	p.S497P	ZNF768_ENST00000562803.1_Missense_Mutation_p.S466P	NM_024671.3	NP_078947.3	Q9H5H4	ZN768_HUMAN	zinc finger protein 768	497					regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	DNA-directed RNA polymerase II, core complex	DNA binding|zinc ion binding			endometrium(2)|kidney(1)|large_intestine(4)|lung(7)|prostate(1)	15						AGCGTGGAGGAGCGGCAGAAG	0.647000													8	46					0	0	1	0	0
FLG	2312	broad.mit.edu	37	1	152275394	152275394	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A5BR-01A-11D-A26M-08	TCGA-FD-A5BR-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afafc062-4c58-491a-8c4b-e714591ac2c2	2c6c386c-6fe4-4b77-ab2b-893aca19a3c6	g.chr1:152275394C>T	ENST00000368799.1	-	3	12003	c.11968G>A	c.(11968-11970)Ggg>Agg	p.G3990R	FLG-AS1_ENST00000593011.1_RNA|FLG-AS1_ENST00000420707.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	3990					keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity	p.G3990W(1)		autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TGTCTAAACCCGGATTCACCA	0.403000									Ichthyosis				28	68					0	0	1	0	0
MPHOSPH9	10198	broad.mit.edu	37	12	123706121	123706121	+	Missense_Mutation	SNP	C	C	A	rs147364688		TCGA-FD-A5BR-01A-11D-A26M-08	TCGA-FD-A5BR-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afafc062-4c58-491a-8c4b-e714591ac2c2	2c6c386c-6fe4-4b77-ab2b-893aca19a3c6	g.chr12:123706121C>A	ENST00000606320.1	-	5	876	c.670G>T	c.(670-672)Gtt>Ttt	p.V224F	MPHOSPH9_ENST00000392425.3_Missense_Mutation_p.V72F|MPHOSPH9_ENST00000302349.5_Missense_Mutation_p.V72F|MPHOSPH9_ENST00000541076.2_Missense_Mutation_p.V194F			Q99550	MPP9_HUMAN	M-phase phosphoprotein 9	72					M phase of mitotic cell cycle	centriole|Golgi membrane				NS(1)|breast(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(18)|prostate(2)|skin(1)	33	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000182)|Epithelial(86;0.00046)|BRCA - Breast invasive adenocarcinoma(302;0.169)		CCTTTGGGAACATCTATGTGC	0.418000													36	45					5.8336e-16	7.39725e-16	1	1	0
C1orf173	127254	broad.mit.edu	37	1	75038381	75038381	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A5BR-01A-11D-A26M-08	TCGA-FD-A5BR-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afafc062-4c58-491a-8c4b-e714591ac2c2	2c6c386c-6fe4-4b77-ab2b-893aca19a3c6	g.chr1:75038381G>A	ENST00000326665.5	-	14	3231	c.3013C>T	c.(3013-3015)Cgg>Tgg	p.R1005W	C1orf173_ENST00000433746.2_5'UTR	NM_001002912.4	NP_001002912.4	Q5RHP9	CA173_HUMAN	chromosome 1 open reading frame 173	1005	Glu-rich.									NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(23)|lung(123)|ovary(3)|prostate(10)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)	184						ACCTGCATCCGGCTTGCCTCT	0.542000													28	41					0	0	1	0	0
TAF5	6877	broad.mit.edu	37	10	105128280	105128280	+	Silent	SNP	C	C	A			TCGA-FD-A5BR-01A-11D-A26M-08	TCGA-FD-A5BR-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afafc062-4c58-491a-8c4b-e714591ac2c2	2c6c386c-6fe4-4b77-ab2b-893aca19a3c6	g.chr10:105128280C>A	ENST00000369839.3	+	1	557	c.534C>A	c.(532-534)gcC>gcA	p.A178A	TAF5_ENST00000351396.4_Silent_p.A178A	NM_006951.3	NP_008882.2	Q15542	TAF5_HUMAN	TAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 100kDa	178					histone acetylation|interspecies interaction between organisms|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	actin cytoskeleton|transcription factor TFIID complex|transcription factor TFTC complex	protein dimerization activity|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			breast(1)|central_nervous_system(1)|kidney(2)|large_intestine(5)|lung(4)|ovary(2)	15		Colorectal(252;0.0747)|Breast(234;0.128)		Epithelial(162;1.83e-09)|all cancers(201;1.4e-08)|BRCA - Breast invasive adenocarcinoma(275;0.198)		CAGGTTCAGCCTCAGGTCCTG	0.741000													3	31					0.115264	0.116209	1	1	0
MGAT2	4247	broad.mit.edu	37	14	50089276	50089276	+	Silent	SNP	G	G	T	rs144122741		TCGA-FD-A5BR-01A-11D-A26M-08	TCGA-FD-A5BR-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afafc062-4c58-491a-8c4b-e714591ac2c2	2c6c386c-6fe4-4b77-ab2b-893aca19a3c6	g.chr14:50089276G>T	ENST00000305386.2	+	1	1788	c.1290G>T	c.(1288-1290)ggG>ggT	p.G430G	RP11-649E7.5_ENST00000555043.1_RNA	NM_002408.3	NP_002399.1	Q10469	MGAT2_HUMAN	mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase	430					oligosaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|Golgi stack|integral to membrane|membrane fraction	alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity			cervix(1)|endometrium(3)|large_intestine(1)|lung(6)	11	all_epithelial(31;0.0021)|Breast(41;0.0124)					AAAATGGAGGGTGGGGAGATA	0.358000													11	34					2.61681e-11	3.28437e-11	1	1	0
SLC22A2	6582	broad.mit.edu	37	6	160679756	160679756	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A5BR-01A-11D-A26M-08	TCGA-FD-A5BR-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afafc062-4c58-491a-8c4b-e714591ac2c2	2c6c386c-6fe4-4b77-ab2b-893aca19a3c6	g.chr6:160679756C>T	ENST00000366953.3	-	1	292	c.34G>A	c.(34-36)Gga>Aga	p.G12R	SLC22A2_ENST00000491092.1_5'UTR|SLC22A2_ENST00000366952.1_Intron	NM_003058.3	NP_003049.2	O15244	S22A2_HUMAN	solute carrier family 22 (organic cation transporter), member 2	12					body fluid secretion|neurotransmitter biosynthetic process|neurotransmitter secretion	integral to plasma membrane|membrane fraction	neurotransmitter transporter activity|organic cation transmembrane transporter activity			breast(2)|endometrium(3)|kidney(1)|large_intestine(2)|lung(16)|prostate(2)|skin(1)	27		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;2.28e-17)|BRCA - Breast invasive adenocarcinoma(81;6.29e-06)		AACTCCCCTCCATGCTCCAGG	0.617000													9	45					0	0	1	0	0
CATSPER2	117155	broad.mit.edu	37	15	43931171	43931171	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A5BR-01A-11D-A26M-08	TCGA-FD-A5BR-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afafc062-4c58-491a-8c4b-e714591ac2c2	2c6c386c-6fe4-4b77-ab2b-893aca19a3c6	g.chr15:43931171G>A	ENST00000396879.1	-	8	885	c.773C>T	c.(772-774)aCt>aTt	p.T258I	STRC_ENST00000541030.1_Intron|CATSPER2_ENST00000381761.1_Missense_Mutation_p.T264I|CATSPER2_ENST00000321596.5_Missense_Mutation_p.T258I|CATSPER2_ENST00000354127.4_Missense_Mutation_p.T258I|CATSPER2_ENST00000355438.2_Missense_Mutation_p.T258I	NM_001282309.1	NP_001269238.1	Q96P56	CTSR2_HUMAN	cation channel, sperm associated 2	258					cell differentiation|multicellular organismal development|spermatogenesis	cilium|flagellar membrane|integral to membrane	calcium channel activity|protein binding|voltage-gated ion channel activity			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(1)|large_intestine(3)|lung(8)|ovary(1)|prostate(1)|skin(1)|urinary_tract(2)	22		all_cancers(109;3.26e-15)|all_epithelial(112;1.48e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.027)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.56e-07)		GTAGACACCAGTCACAGCAAA	0.512000													7	43					0	0	1	0	0
LRRC37A6P	387646	broad.mit.edu	37	10	27537202	27537202	+	RNA	SNP	G	G	T			TCGA-FD-A5BR-01A-11D-A26M-08	TCGA-FD-A5BR-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afafc062-4c58-491a-8c4b-e714591ac2c2	2c6c386c-6fe4-4b77-ab2b-893aca19a3c6	g.chr10:27537202G>T	ENST00000574842.1	+	0	255				LRRC37A6P_ENST00000284414.4_RNA																							GAACACTCCTGGATTCTCTAC	0.478000													10	70					0.0692343	0.0703787	1	1	0
FMOD	2331	broad.mit.edu	37	1	203317224	203317224	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A5BR-01A-11D-A26M-08	TCGA-FD-A5BR-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afafc062-4c58-491a-8c4b-e714591ac2c2	2c6c386c-6fe4-4b77-ab2b-893aca19a3c6	g.chr1:203317224C>T	ENST00000354955.4	-	2	638	c.175G>A	c.(175-177)Gaa>Aaa	p.E59K	FMOD_ENST00000493296.1_Intron	NM_002023.4	NP_002014.2	Q06828	FMOD_HUMAN	fibromodulin	59					transforming growth factor beta receptor complex assembly	extracellular space|proteinaceous extracellular matrix				breast(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(4)|ovary(2)|prostate(2)|upper_aerodigestive_tract(2)	17			BRCA - Breast invasive adenocarcinoma(75;0.171)			GCTGGCCCTTCATCCACCCCA	0.612000													12	38					0	0	1	0	0
SFTA3	253970	broad.mit.edu	37	14	36946256	36946256	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A5BR-01A-11D-A26M-08	TCGA-FD-A5BR-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afafc062-4c58-491a-8c4b-e714591ac2c2	2c6c386c-6fe4-4b77-ab2b-893aca19a3c6	g.chr14:36946256C>T	ENST00000518529.2	-	3	856	c.181G>A	c.(181-183)Gtg>Atg	p.V61M	SFTA3_ENST00000518987.1_Intron|RP11-896J10.3_ENST00000521945.1_RNA	NM_001101341.1	NP_001094811.1	P0C7M3	SFTA3_HUMAN	surfactant associated 3	61										breast(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(2)|skin(1)	7						GGACTTGGCACGCAAACAGCG	0.522000													22	89					0	0	1	0	0
HNF1B	6928	broad.mit.edu	37	17	36093623	36093623	+	Silent	SNP	A	A	G			TCGA-FD-A5BR-01A-11D-A26M-08	TCGA-FD-A5BR-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afafc062-4c58-491a-8c4b-e714591ac2c2	2c6c386c-6fe4-4b77-ab2b-893aca19a3c6	g.chr17:36093623A>G	ENST00000225893.4	-	3	1097	c.736T>C	c.(736-738)Ttg>Ctg	p.L246L	HNF1B_ENST00000427275.2_Silent_p.L220L|HNF1B_ENST00000561193.1_Silent_p.L220L|HNF1B_ENST00000560016.1_Silent_p.L246L	NM_000458.2|NM_001165923.1	NP_000449.1|NP_001159395.1	P35680	HNF1B_HUMAN	HNF1 homeobox B	246					endocrine pancreas development|genitalia development|kidney development|positive regulation of transcription initiation from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|pronephric nephron tubule development|regulation of pronephros size	nucleus	DNA binding|protein homodimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|central_nervous_system(3)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(6)|kidney(3)|large_intestine(2)|liver(1)|lung(3)|ovary(3)|prostate(1)|skin(2)	28		Breast(25;0.00765)|Ovarian(249;0.15)	STAD - Stomach adenocarcinoma(1;0.0142)			GCCTGGTACAAGATTTGCTGG	0.587000													19	122					0	0	1	0	0
CLPTM1L	81037	broad.mit.edu	37	5	1321774	1321774	+	Silent	SNP	C	C	A			TCGA-FD-A5BR-01A-11D-A26M-08	TCGA-FD-A5BR-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afafc062-4c58-491a-8c4b-e714591ac2c2	2c6c386c-6fe4-4b77-ab2b-893aca19a3c6	g.chr5:1321774C>A	ENST00000320895.5	-	15	1649	c.1392G>T	c.(1390-1392)ctG>ctT	p.L464L	CLPTM1L_ENST00000320927.6_Silent_p.L428L|CLPTM1L_ENST00000506641.1_5'UTR|CLPTM1L_ENST00000507807.1_Silent_p.L295L	NM_030782.3	NP_110409.2	Q96KA5	CLP1L_HUMAN	CLPTM1-like	464					apoptosis	integral to membrane				breast(2)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(2)|lung(6)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	24	Lung NSC(6;5.78e-14)|all_lung(6;4.47e-13)|all_epithelial(6;4.47e-09)		Epithelial(17;0.00931)|OV - Ovarian serous cystadenocarcinoma(19;0.0116)|all cancers(22;0.0181)	KIRC - Kidney renal clear cell carcinoma(5;0.177)|Kidney(13;0.208)		CCTTCCAGGGCAGATGTGCCA	0.622000													12	126					0.00185496	0.00195008	1	1	0
RAD21	5885	broad.mit.edu	37	8	117878903	117878903	+	Silent	SNP	A	A	G			TCGA-FD-A5BR-01A-11D-A26M-08	TCGA-FD-A5BR-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afafc062-4c58-491a-8c4b-e714591ac2c2	2c6c386c-6fe4-4b77-ab2b-893aca19a3c6	g.chr8:117878903A>G	ENST00000297338.2	-	2	353	c.66T>C	c.(64-66)caT>caC	p.H22H	RAD21_ENST00000523547.1_5'UTR	NM_006265.2	NP_006256.1	O60216	RAD21_HUMAN	RAD21 homolog (S. pombe)	22					apoptosis|cell division|chromosome segregation|double-strand break repair|mitotic metaphase/anaphase transition|mitotic prometaphase|protein localization to chromatin|reciprocal meiotic recombination|regulation of transcription from RNA polymerase II promoter	chromosome, centromeric region|cohesin complex|nuclear chromosome|nucleoplasm	protein binding			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(16)|ovary(1)|prostate(1)|skin(1)|stomach(1)	32	all_cancers(13;1.21e-21)|Lung NSC(37;0.000134)|Ovarian(258;0.0172)					TCTTATCCCAATGGGCCGCTA	0.428000													4	64					0	0	1	0	0
SPTA1	6708	broad.mit.edu	37	1	158623143	158623143	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A5BR-01A-11D-A26M-08	TCGA-FD-A5BR-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afafc062-4c58-491a-8c4b-e714591ac2c2	2c6c386c-6fe4-4b77-ab2b-893aca19a3c6	g.chr1:158623143C>T	ENST00000368147.4	-	22	3289	c.3109G>A	c.(3109-3111)Gat>Aat	p.D1037N		NM_003126.2	NP_003117.2	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1 (elliptocytosis 2)						actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			NS(3)|breast(7)|cervix(1)|endometrium(22)|kidney(9)|large_intestine(29)|liver(2)|lung(183)|ovary(5)|prostate(18)|skin(11)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(6)	307	all_hematologic(112;0.0378)					GGGAACTCATCGTGGGCCAGT	0.572000													13	82					0	0	1	0	0
FTCD	10841	broad.mit.edu	37	21	47556892	47556892	+	Nonsense_Mutation	SNP	C	C	A			TCGA-FD-A5BR-01A-11D-A26M-08	TCGA-FD-A5BR-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afafc062-4c58-491a-8c4b-e714591ac2c2	2c6c386c-6fe4-4b77-ab2b-893aca19a3c6	g.chr21:47556892C>A	ENST00000397748.1	-	14	1658	c.1615G>T	c.(1615-1617)Gag>Tag	p.E539*	FTCD_ENST00000397743.1_3'UTR|FTCD_ENST00000359679.2_Nonsense_Mutation_p.E539*|FTCD_ENST00000355384.2_Intron|FTCD_ENST00000498355.2_Splice_Site|FTCD_ENST00000291670.5_Intron|FTCD_ENST00000397746.3_3'UTR			O95954	FTCD_HUMAN	formimidoyltransferase cyclodeaminase	46	Cyclodeaminase/cyclohydrolase (By similarity).				folic acid-containing compound metabolic process|histidine catabolic process	centriole|cytosol|Golgi apparatus	folic acid binding|formimidoyltetrahydrofolate cyclodeaminase activity|glutamate formimidoyltransferase activity			endometrium(1)|large_intestine(2)|lung(9)|pancreas(1)|prostate(3)|skin(3)	19	Breast(49;0.214)			Colorectal(79;0.235)	L-Glutamic Acid(DB00142)|Pyridoxal Phosphate(DB00114)|Tetrahydrofolic acid(DB00116)	GGAGAGGCCTCCCGCACCGTC	0.662000													13	42					2.31682e-05	2.56729e-05	1	1	0
TMEM9B	56674	broad.mit.edu	37	11	8977775	8977775	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A5BR-01A-11D-A26M-08	TCGA-FD-A5BR-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afafc062-4c58-491a-8c4b-e714591ac2c2	2c6c386c-6fe4-4b77-ab2b-893aca19a3c6	g.chr11:8977775C>T	ENST00000534025.1	-	3	727	c.268G>A	c.(268-270)Gaa>Aaa	p.E90K	TMEM9B_ENST00000528117.1_Missense_Mutation_p.E16K|TMEM9B_ENST00000309134.5_Missense_Mutation_p.E16K|TMEM9B_ENST00000525069.1_Missense_Mutation_p.E16K	NM_020644.1	NP_065695.1	Q9NQ34	TMM9B_HUMAN	TMEM9 domain family, member B	90					positive regulation of I-kappaB kinase/NF-kappaB cascade	integral to membrane	signal transducer activity			breast(1)|lung(1)|prostate(1)	3				Epithelial(150;4.39e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0237)		TATTTGCATTCACAGCGTAGA	0.423000													18	20					0	0	1	0	0
BMPR1B	658	broad.mit.edu	37	4	96036889	96036889	+	Missense_Mutation	SNP	C	C	T	rs140499888	byFrequency	TCGA-FD-A5BR-01A-11D-A26M-08	TCGA-FD-A5BR-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afafc062-4c58-491a-8c4b-e714591ac2c2	2c6c386c-6fe4-4b77-ab2b-893aca19a3c6	g.chr4:96036889C>T	ENST00000502683.1	+	4	516	c.305C>T	c.(304-306)aCg>aTg	p.T102M	BMPR1B_ENST00000264568.4_Silent_p.N100N|BMPR1B_ENST00000440890.2_Silent_p.N130N|BMPR1B_ENST00000515059.1_Silent_p.N100N|BMPR1B_ENST00000394931.1_Silent_p.N100N			O00238	BMR1B_HUMAN	bone morphogenetic protein receptor, type IB	0					BMP signaling pathway|cartilage condensation|eye development|limb morphogenesis|ovarian cumulus expansion|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	receptor complex	ATP binding|metal ion binding|receptor signaling protein serine/threonine kinase activity|SMAD binding|transforming growth factor beta receptor activity			breast(3)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(11)|lung(8)|ovary(1)|pancreas(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	31		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;6.51e-07)		CAGAAAGGAACGAATGTAATA	0.398000													9	73					0	0	1	0	0
SLC12A2	6558	broad.mit.edu	37	5	127484562	127484562	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A5BR-01A-11D-A26M-08	TCGA-FD-A5BR-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afafc062-4c58-491a-8c4b-e714591ac2c2	2c6c386c-6fe4-4b77-ab2b-893aca19a3c6	g.chr5:127484562C>G	ENST00000262461.2	+	12	2187	c.1998C>G	c.(1996-1998)atC>atG	p.I666M	SLC12A2_ENST00000343225.4_Missense_Mutation_p.I666M	NM_001046.2	NP_001037.1	P55011	S12A2_HUMAN	solute carrier family 12 (sodium/potassium/chloride transporter), member 2	666					potassium ion transport|sodium ion transport|transepithelial ammonium transport|transepithelial chloride transport	integral to plasma membrane|membrane fraction	ammonia transmembrane transporter activity|sodium:potassium:chloride symporter activity			breast(3)|endometrium(5)|kidney(5)|large_intestine(12)|lung(16)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	48		all_cancers(142;0.0972)|Prostate(80;0.151)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	Epithelial(69;0.0433)|OV - Ovarian serous cystadenocarcinoma(64;0.0978)	Bumetanide(DB00887)|Potassium Chloride(DB00761)	TTGGATTCATCTTAATTGGTT	0.308000													8	100					0	0	1	0	0
SLC12A2	6558	broad.mit.edu	37	5	127483419	127483419	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FD-A5BR-01A-11D-A26M-08	TCGA-FD-A5BR-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afafc062-4c58-491a-8c4b-e714591ac2c2	2c6c386c-6fe4-4b77-ab2b-893aca19a3c6	g.chr5:127483419C>T	ENST00000262461.2	+	11	2068	c.1879C>T	c.(1879-1881)Cag>Tag	p.Q627*	SLC12A2_ENST00000343225.4_Nonsense_Mutation_p.Q627*	NM_001046.2	NP_001037.1	P55011	S12A2_HUMAN	solute carrier family 12 (sodium/potassium/chloride transporter), member 2	627					potassium ion transport|sodium ion transport|transepithelial ammonium transport|transepithelial chloride transport	integral to plasma membrane|membrane fraction	ammonia transmembrane transporter activity|sodium:potassium:chloride symporter activity			breast(3)|endometrium(5)|kidney(5)|large_intestine(12)|lung(16)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	48		all_cancers(142;0.0972)|Prostate(80;0.151)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	Epithelial(69;0.0433)|OV - Ovarian serous cystadenocarcinoma(64;0.0978)	Bumetanide(DB00887)|Potassium Chloride(DB00761)	CAAAATATTTCAGGTAAGTGT	0.333000													4	37					0	0	1	0	0
REG1A	5967	broad.mit.edu	37	2	79350028	79350028	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A5BR-01A-11D-A26M-08	TCGA-FD-A5BR-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afafc062-4c58-491a-8c4b-e714591ac2c2	2c6c386c-6fe4-4b77-ab2b-893aca19a3c6	g.chr2:79350028C>T	ENST00000233735.1	+	5	486	c.383C>T	c.(382-384)gCc>gTc	p.A128V		NM_002909.4	NP_002900.2	P05451	REG1A_HUMAN	regenerating islet-derived 1 alpha	128	C-type lectin.				positive regulation of cell proliferation	extracellular region	growth factor activity|sugar binding			NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(5)|lung(26)|prostate(1)|upper_aerodigestive_tract(1)	39						GGCATTGGAGCCCCAAGCAGT	0.572000													51	91					0	0	1	0	0
MED13	9969	broad.mit.edu	37	17	60024360	60024360	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A5BR-01A-11D-A26M-08	TCGA-FD-A5BR-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afafc062-4c58-491a-8c4b-e714591ac2c2	2c6c386c-6fe4-4b77-ab2b-893aca19a3c6	g.chr17:60024360C>T	ENST00000397786.2	-	29	6386	c.6310G>A	c.(6310-6312)Gtg>Atg	p.V2104M		NM_005121.2	NP_005112.2	Q9UHV7	MED13_HUMAN	mediator complex subunit 13	2104					androgen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			breast(4)|central_nervous_system(1)|endometrium(10)|kidney(24)|large_intestine(15)|liver(1)|lung(20)|ovary(1)|prostate(3)|skin(2)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	88						ACTGAAGGCACGTGGAGGTGC	0.418000													17	93					0	0	1	0	0
FBN2	2201	broad.mit.edu	37	5	127653946	127653946	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A5BR-01A-11D-A26M-08	TCGA-FD-A5BR-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afafc062-4c58-491a-8c4b-e714591ac2c2	2c6c386c-6fe4-4b77-ab2b-893aca19a3c6	g.chr5:127653946C>A	ENST00000508053.1	-	42	5586	c.4612G>T	c.(4612-4614)Gat>Tat	p.D1538Y	FBN2_ENST00000262464.4_Missense_Mutation_p.D1538Y			P35556	FBN2_HUMAN	fibrillin 2	1538	EGF-like 26; calcium-binding.				bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			NS(1)|autonomic_ganglia(1)|biliary_tract(1)|breast(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(37)|liver(1)|lung(89)|ovary(9)|pancreas(2)|prostate(6)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	197		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		TTTATAGGATCTGCACACTCA	0.428000													16	113					6.94344e-10	8.45588e-10	1	1	0
MVD	4597	broad.mit.edu	37	16	88721706	88721706	+	Silent	SNP	G	G	C			TCGA-FD-A5BR-01A-11D-A26M-08	TCGA-FD-A5BR-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afafc062-4c58-491a-8c4b-e714591ac2c2	2c6c386c-6fe4-4b77-ab2b-893aca19a3c6	g.chr16:88721706G>C	ENST00000301012.3	-	7	827	c.798C>G	c.(796-798)acC>acG	p.T266T		NM_002461.1	NP_002452.1	P53602	MVD1_HUMAN	mevalonate (diphospho) decarboxylase	266					cholesterol biosynthetic process|positive regulation of cell proliferation	cytosol	ATP binding|diphosphomevalonate decarboxylase activity|Hsp70 protein binding|kinase activity|protein homodimerization activity			endometrium(3)|large_intestine(1)|lung(7)|ovary(1)	12				BRCA - Breast invasive adenocarcinoma(80;0.0478)		TGTCGAGGCAGGTGGCGTGGA	0.647000													5	11					0	0	1	0	0
PAPD7	11044	broad.mit.edu	37	5	6743869	6743869	+	Silent	SNP	C	C	T			TCGA-FD-A5BR-01A-11D-A26M-08	TCGA-FD-A5BR-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afafc062-4c58-491a-8c4b-e714591ac2c2	2c6c386c-6fe4-4b77-ab2b-893aca19a3c6	g.chr5:6743869C>T	ENST00000230859.6	+	6	540	c.411C>T	c.(409-411)ttC>ttT	p.F137F		NM_001171805.1|NM_001171806.1|NM_006999.4	NP_001165276.1|NP_001165277.1|NP_008930.1	Q5XG87	PAPD7_HUMAN	PAP associated domain containing 7	137					cell division|DNA replication|double-strand break repair|mitotic chromosome condensation|response to drug|sister chromatid cohesion	nucleus	DNA binding|DNA-directed DNA polymerase activity|metal ion binding|SMC protein binding			cervix(1)|endometrium(2)|large_intestine(8)|lung(10)|ovary(2)|pancreas(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	27						TGAAACAGTTCCTTCTGCAGA	0.333000													31	45					0	0	1	0	0
SLC12A2	6558	broad.mit.edu	37	5	127488425	127488425	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A5BR-01A-11D-A26M-08	TCGA-FD-A5BR-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afafc062-4c58-491a-8c4b-e714591ac2c2	2c6c386c-6fe4-4b77-ab2b-893aca19a3c6	g.chr5:127488425C>T	ENST00000262461.2	+	15	2480	c.2291C>T	c.(2290-2292)gCc>gTc	p.A764V	SLC12A2_ENST00000343225.4_Missense_Mutation_p.A764V	NM_001046.2	NP_001037.1	P55011	S12A2_HUMAN	solute carrier family 12 (sodium/potassium/chloride transporter), member 2	764					potassium ion transport|sodium ion transport|transepithelial ammonium transport|transepithelial chloride transport	integral to plasma membrane|membrane fraction	ammonia transmembrane transporter activity|sodium:potassium:chloride symporter activity			breast(3)|endometrium(5)|kidney(5)|large_intestine(12)|lung(16)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	48		all_cancers(142;0.0972)|Prostate(80;0.151)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	Epithelial(69;0.0433)|OV - Ovarian serous cystadenocarcinoma(64;0.0978)	Bumetanide(DB00887)|Potassium Chloride(DB00761)	TCTACACAAGCCCTGACTTAC	0.413000													3	25					0	0	1	0	0
MMD2	221938	broad.mit.edu	37	7	4949617	4949617	+	Silent	SNP	T	T	G			TCGA-FD-A5BR-01A-11D-A26M-08	TCGA-FD-A5BR-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afafc062-4c58-491a-8c4b-e714591ac2c2	2c6c386c-6fe4-4b77-ab2b-893aca19a3c6	g.chr7:4949617T>G	ENST00000404774.3	-	6	698	c.504A>C	c.(502-504)gcA>gcC	p.A168A	MMD2_ENST00000406755.1_Intron|MMD2_ENST00000401401.3_Intron	NM_001100600.1	NP_001094070.1	Q8IY49	PAQRA_HUMAN	monocyte to macrophage differentiation-associated 2	168						integral to membrane	receptor activity			central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(11)	14		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.097)|OV - Ovarian serous cystadenocarcinoma(56;3.4e-14)		CCTTAGGACATGCCTCCCCAC	0.562000													21	81					0	0	1	0	0
BUB1	699	broad.mit.edu	37	2	111416254	111416254	+	Missense_Mutation	SNP	T	T	C			TCGA-FD-A5BR-01A-11D-A26M-08	TCGA-FD-A5BR-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afafc062-4c58-491a-8c4b-e714591ac2c2	2c6c386c-6fe4-4b77-ab2b-893aca19a3c6	g.chr2:111416254T>C	ENST00000535254.1	-	11	1349	c.1282A>G	c.(1282-1284)Atg>Gtg	p.M428V	BUB1_ENST00000409311.1_Missense_Mutation_p.M448V|BUB1_ENST00000302759.6_Missense_Mutation_p.M448V	NM_001278616.1	NP_001265545.1	O43683	BUB1_HUMAN	BUB1 mitotic checkpoint serine/threonine kinase	448					apoptosis|cell division|chromosome segregation|interspecies interaction between organisms|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|regulation of sister chromatid cohesion	condensed chromosome kinetochore|cytosol	ATP binding|protein binding|protein serine/threonine kinase activity			breast(3)|endometrium(8)|kidney(4)|large_intestine(9)|lung(18)|ovary(1)|prostate(1)|stomach(1)	45		Ovarian(717;0.0822)		BRCA - Breast invasive adenocarcinoma(221;0.0556)		GCCTGAACCATTCCCAGTGAT	0.438000													13	34					0	0	1	0	0
OPA1	4976	broad.mit.edu	37	3	193353261	193353261	+	Nonsense_Mutation	SNP	A	A	T			TCGA-FD-A5BR-01A-11D-A26M-08	TCGA-FD-A5BR-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afafc062-4c58-491a-8c4b-e714591ac2c2	2c6c386c-6fe4-4b77-ab2b-893aca19a3c6	g.chr3:193353261A>T	ENST00000361510.2	+	9	1132	c.898A>T	c.(898-900)Aaa>Taa	p.K300*	OPA1_ENST00000361828.2_Nonsense_Mutation_p.K263*|OPA1_ENST00000361715.2_Nonsense_Mutation_p.K264*|OPA1_ENST00000361908.3_Nonsense_Mutation_p.K282*|OPA1_ENST00000361150.2_Nonsense_Mutation_p.K246*|OPA1_ENST00000392438.3_Nonsense_Mutation_p.K245*	NM_130837.2	NP_570850.2	O60313	OPA1_HUMAN	optic atrophy 1 (autosomal dominant)	245			G -> E (in OPA1).		apoptosis|axon transport of mitochondrion|inner mitochondrial membrane organization|mitochondrial fission|mitochondrial fusion|positive regulation of anti-apoptosis|response to stimulus|visual perception	dendrite|integral to membrane|mitochondrial crista|mitochondrial intermembrane space|mitochondrial outer membrane	GTP binding|GTPase activity|magnesium ion binding|protein binding			breast(1)|cervix(2)|endometrium(3)|kidney(3)|large_intestine(4)|lung(15)|upper_aerodigestive_tract(1)|urinary_tract(2)	31	all_cancers(143;9.56e-09)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(49;9.19e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;0.000162)		AGAATTGAGAAAATTAGTATT	0.303000													14	51					0	0	1	0	0
MTDH	92140	broad.mit.edu	37	8	98718944	98718944	+	Missense_Mutation	SNP	T	T	G			TCGA-FD-A5BR-01A-11D-A26M-08	TCGA-FD-A5BR-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afafc062-4c58-491a-8c4b-e714591ac2c2	2c6c386c-6fe4-4b77-ab2b-893aca19a3c6	g.chr8:98718944T>G	ENST00000336273.3	+	8	1566	c.1238T>G	c.(1237-1239)cTa>cGa	p.L413R	MTDH_ENST00000519934.1_Missense_Mutation_p.L357R	NM_178812.3	NP_848927.2	Q86UE4	LYRIC_HUMAN	metadherin	413	Lung-homing for mammary tumors (By similarity).				lipopolysaccharide-mediated signaling pathway|negative regulation of apoptosis|negative regulation of transcription from RNA polymerase II promoter|positive regulation of angiogenesis|positive regulation of autophagy|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of protein kinase B signaling cascade	apical plasma membrane|endoplasmic reticulum membrane|integral to membrane|intercellular canaliculus|nuclear body|nuclear membrane|nucleolus|perinuclear region of cytoplasm|tight junction	NF-kappaB binding|RNA polymerase II transcription factor binding|transcription coactivator activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(6)|large_intestine(5)|liver(1)|lung(8)|ovary(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	32	Breast(36;2.56e-06)		OV - Ovarian serous cystadenocarcinoma(57;0.178)			GCTTCACTTCTAAAGTCCCAG	0.438000													26	256					0	0	1	0	0
ZKSCAN5	23660	broad.mit.edu	37	7	99110164	99110164	+	Missense_Mutation	SNP	A	A	T			TCGA-FD-A5BR-01A-11D-A26M-08	TCGA-FD-A5BR-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afafc062-4c58-491a-8c4b-e714591ac2c2	2c6c386c-6fe4-4b77-ab2b-893aca19a3c6	g.chr7:99110164A>T	ENST00000394170.2	+	3	754	c.503A>T	c.(502-504)gAc>gTc	p.D168V	ZKSCAN5_ENST00000326775.5_Missense_Mutation_p.D168V|ZKSCAN5_ENST00000451158.1_Missense_Mutation_p.D168V	NM_014569.3	NP_055384.1	Q9Y2L8	ZKSC5_HUMAN	zinc finger with KRAB and SCAN domains 5	168					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(3)|endometrium(1)|kidney(1)|large_intestine(6)|lung(6)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	21	all_cancers(62;2.54e-08)|all_epithelial(64;2.55e-09)|Lung NSC(181;0.0053)|all_lung(186;0.00895)|Esophageal squamous(72;0.0166)					CTGACCGTGGACACCCAGCCT	0.567000													20	34					0	0	1	0	0
LONP2	83752	broad.mit.edu	37	16	48382162	48382162	+	Silent	SNP	C	C	A			TCGA-FD-A5BR-01A-11D-A26M-08	TCGA-FD-A5BR-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afafc062-4c58-491a-8c4b-e714591ac2c2	2c6c386c-6fe4-4b77-ab2b-893aca19a3c6	g.chr16:48382162C>A	ENST00000285737.4	+	14	2391	c.2298C>A	c.(2296-2298)gcC>gcA	p.A766A	LONP2_ENST00000564259.1_3'UTR|LONP2_ENST00000535754.1_Silent_p.A722A	NM_031490.2	NP_113678.2	Q86WA8	LONP2_HUMAN	lon peptidase 2, peroxisomal	766					misfolded or incompletely synthesized protein catabolic process|protein targeting to peroxisome|signal peptide processing	nucleoid|peroxisomal matrix	ATP binding|ATP-dependent peptidase activity|enzyme binding|sequence-specific DNA binding|serine-type endopeptidase activity			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(13)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	31						CAGATGTAGCCATGACTGGAG	0.373000													35	80					2.05212e-20	2.71409e-20	1	1	0
CDH13	1012	broad.mit.edu	37	16	83711832	83711832	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A5BR-01A-11D-A26M-08	TCGA-FD-A5BR-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afafc062-4c58-491a-8c4b-e714591ac2c2	2c6c386c-6fe4-4b77-ab2b-893aca19a3c6	g.chr16:83711832C>A	ENST00000566620.1	+	10	1594	c.1304C>A	c.(1303-1305)tCt>tAt	p.S435Y	CDH13_ENST00000428848.3_Missense_Mutation_p.S396Y|CDH13_ENST00000268613.10_Missense_Mutation_p.S482Y	NM_001220488.1|NM_001220489.1|NM_001220490.1|NM_001257.4	NP_001207417.1|NP_001207418.1|NP_001207419.1|NP_001248.1	P55290	CAD13_HUMAN	cadherin 13	435	Cadherin 3.				adherens junction organization|calcium-dependent cell-cell adhesion|cell junction assembly|endothelial cell migration|homophilic cell adhesion|keratinocyte proliferation|lamellipodium assembly|localization within membrane|low-density lipoprotein particle mediated signaling|negative regulation of cell adhesion|negative regulation of cell proliferation|positive regulation of calcium-mediated signaling|positive regulation of cell migration|positive regulation of cell-matrix adhesion|positive regulation of endothelial cell proliferation|positive regulation of positive chemotaxis|positive regulation of smooth muscle cell proliferation|positive regulation of survival gene product expression|Rac protein signal transduction|regulation of endocytosis|regulation of epidermal growth factor receptor signaling pathway|Rho protein signal transduction|sprouting angiogenesis	anchored to membrane|caveola|extracellular space|integral to membrane|neuron projection	adiponectin binding|cadherin binding|calcium ion binding|low-density lipoprotein particle binding			large_intestine(1)	1		all_cancers(2;1.34e-11)|all_epithelial(2;4.3e-09)		COAD - Colon adenocarcinoma(5;0.0268)		TATGAAATTTCTGCCTTCCAC	0.527000													10	33					3.86212e-05	4.24143e-05	1	1	0
PCLO	27445	broad.mit.edu	37	7	82584839	82584839	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A5BR-01A-11D-A26M-08	TCGA-FD-A5BR-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afafc062-4c58-491a-8c4b-e714591ac2c2	2c6c386c-6fe4-4b77-ab2b-893aca19a3c6	g.chr7:82584839G>T	ENST00000333891.9	-	5	5767	c.5430C>A	c.(5428-5430)gaC>gaA	p.D1810E	PCLO_ENST00000423517.2_Missense_Mutation_p.D1810E	NM_033026.5	NP_149015.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein						cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						GTTCATCTTTGTCTTTCTTTG	0.393000													45	72					5.78141e-17	7.48541e-17	1	1	0
MYO18A	399687	broad.mit.edu	37	17	27414063	27414063	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A5BR-01A-11D-A26M-08	TCGA-FD-A5BR-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afafc062-4c58-491a-8c4b-e714591ac2c2	2c6c386c-6fe4-4b77-ab2b-893aca19a3c6	g.chr17:27414063C>T	ENST00000527372.1	-	38	5783	c.5603G>A	c.(5602-5604)cGg>cAg	p.R1868Q	MYO18A_ENST00000529578.1_5'UTR|MYO18A_ENST00000533112.1_Missense_Mutation_p.R1831Q|MYO18A_ENST00000354329.4_Missense_Mutation_p.R1868Q|MYO18A_ENST00000531253.1_Missense_Mutation_p.R1868Q|TIAF1_ENST00000408971.2_5'UTR	NM_078471.3	NP_510880.2	Q92614	MY18A_HUMAN	myosin XVIIIA	1868					anti-apoptosis|DNA metabolic process	ER-Golgi intermediate compartment|myosin complex	ATP binding|DNA binding|DNA-dependent ATPase activity|identical protein binding|motor activity			NS(1)|cervix(1)|endometrium(6)|kidney(6)|lung(20)|urinary_tract(2)	36			Epithelial(11;4.97e-05)|BRCA - Breast invasive adenocarcinoma(11;0.000221)|all cancers(11;0.000234)|Colorectal(6;0.0102)|COAD - Colon adenocarcinoma(6;0.031)			TTCCTTCTCCCGGTTCTCGGC	0.597000													10	103					0	0	1	0	0
TMEM132B	114795	broad.mit.edu	37	12	126135302	126135302	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A5BR-01A-11D-A26M-08	TCGA-FD-A5BR-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afafc062-4c58-491a-8c4b-e714591ac2c2	2c6c386c-6fe4-4b77-ab2b-893aca19a3c6	g.chr12:126135302G>A	ENST00000299308.3	+	7	1710	c.1702G>A	c.(1702-1704)Gcc>Acc	p.A568T	TMEM132B_ENST00000535886.1_Missense_Mutation_p.A80T	NM_052907.2	NP_443139.2	Q14DG7	T132B_HUMAN	transmembrane protein 132B	568						integral to membrane				NS(1)|breast(9)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(11)|liver(1)|lung(45)|ovary(5)|pancreas(1)|prostate(4)|skin(15)|upper_aerodigestive_tract(3)|urinary_tract(1)	107	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000423)|Epithelial(86;0.00394)|all cancers(50;0.0362)		GTACCAGCACGCCACAGTGCG	0.587000													21	36					0	0	1	0	0
PRDM10	56980	broad.mit.edu	37	11	129772240	129772240	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A5BR-01A-11D-A26M-08	TCGA-FD-A5BR-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afafc062-4c58-491a-8c4b-e714591ac2c2	2c6c386c-6fe4-4b77-ab2b-893aca19a3c6	g.chr11:129772240C>T	ENST00000358825.5	-	22	3682	c.3451G>A	c.(3451-3453)Gga>Aga	p.G1151R	PRDM10_ENST00000360871.3_Missense_Mutation_p.G1147R|PRDM10_ENST00000526082.1_Missense_Mutation_p.G1065R|PRDM10_ENST00000528746.1_Missense_Mutation_p.G1108R|PRDM10_ENST00000304538.6_Missense_Mutation_p.G1014R|PRDM10_ENST00000423662.2_Missense_Mutation_p.G1052R	NM_020228.2	NP_064613.2	Q9NQV6	PRD10_HUMAN	PR domain containing 10	1138					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(6)|kidney(3)|large_intestine(14)|lung(15)|pancreas(2)|skin(1)|stomach(3)|urinary_tract(2)	48	all_hematologic(175;0.0537)	Breast(109;0.000496)|Lung NSC(97;0.000693)|all_lung(97;0.00151)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.0174)|Lung(977;0.176)|LUSC - Lung squamous cell carcinoma(976;0.185)		TCGCTGCTTCCGTTCCCGTTG	0.547000													6	106					0	0	1	0	0
RRP7BP	91695	broad.mit.edu	37	22	42972590	42972590	+	RNA	SNP	A	A	G	rs137071	by1000genomes	TCGA-FD-A5BR-01A-11D-A26M-08	TCGA-FD-A5BR-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afafc062-4c58-491a-8c4b-e714591ac2c2	2c6c386c-6fe4-4b77-ab2b-893aca19a3c6	g.chr22:42972590A>G	ENST00000357802.2	-	0	515																											GGTCGGGCACAGAGTCTGCGT	0.642000													3	15					0	0	1	0	0
SLC12A2	6558	broad.mit.edu	37	5	127483339	127483339	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A5BR-01A-11D-A26M-08	TCGA-FD-A5BR-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afafc062-4c58-491a-8c4b-e714591ac2c2	2c6c386c-6fe4-4b77-ab2b-893aca19a3c6	g.chr5:127483339C>T	ENST00000262461.2	+	11	1988	c.1799C>T	c.(1798-1800)aCa>aTa	p.T600I	SLC12A2_ENST00000343225.4_Missense_Mutation_p.T600I	NM_001046.2	NP_001037.1	P55011	S12A2_HUMAN	solute carrier family 12 (sodium/potassium/chloride transporter), member 2	600					potassium ion transport|sodium ion transport|transepithelial ammonium transport|transepithelial chloride transport	integral to plasma membrane|membrane fraction	ammonia transmembrane transporter activity|sodium:potassium:chloride symporter activity			breast(3)|endometrium(5)|kidney(5)|large_intestine(12)|lung(16)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	48		all_cancers(142;0.0972)|Prostate(80;0.151)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	Epithelial(69;0.0433)|OV - Ovarian serous cystadenocarcinoma(64;0.0978)	Bumetanide(DB00887)|Potassium Chloride(DB00761)	TCAGGATTTACACCACTAATT	0.318000													7	47					0	0	1	0	0
FBN2	2201	broad.mit.edu	37	5	127653958	127653958	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A5BR-01A-11D-A26M-08	TCGA-FD-A5BR-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afafc062-4c58-491a-8c4b-e714591ac2c2	2c6c386c-6fe4-4b77-ab2b-893aca19a3c6	g.chr5:127653958C>T	ENST00000508053.1	-	42	5574	c.4600G>A	c.(4600-4602)Gat>Aat	p.D1534N	FBN2_ENST00000262464.4_Missense_Mutation_p.D1534N			P35556	FBN2_HUMAN	fibrillin 2	1534	EGF-like 26; calcium-binding.				bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			NS(1)|autonomic_ganglia(1)|biliary_tract(1)|breast(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(37)|liver(1)|lung(89)|ovary(9)|pancreas(2)|prostate(6)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	197		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		GCACACTCATCAATATCTAGG	0.418000													17	107					0	0	1	0	0
TBC1D13	54662	broad.mit.edu	37	9	131550683	131550683	+	Missense_Mutation	SNP	A	A	C			TCGA-FD-A5BR-01A-11D-A26M-08	TCGA-FD-A5BR-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afafc062-4c58-491a-8c4b-e714591ac2c2	2c6c386c-6fe4-4b77-ab2b-893aca19a3c6	g.chr9:131550683A>C	ENST00000372648.5	+	2	244	c.94A>C	c.(94-96)Agt>Cgt	p.S32R	TBC1D13_ENST00000539497.1_5'UTR|TBC1D13_ENST00000223865.8_Missense_Mutation_p.S32R|TBC1D13_ENST00000466056.1_3'UTR	NM_018201.3	NP_060671.3	Q9NVG8	TBC13_HUMAN	TBC1 domain family, member 13	32						intracellular	Rab GTPase activator activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(2)	6						ACTCAGCTTTAGTGGTAAGAA	0.532000													28	67					0	0	1	0	0
FBN2	2201	broad.mit.edu	37	5	127653964	127653964	+	Splice_Site	SNP	C	C	T			TCGA-FD-A5BR-01A-11D-A26M-08	TCGA-FD-A5BR-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afafc062-4c58-491a-8c4b-e714591ac2c2	2c6c386c-6fe4-4b77-ab2b-893aca19a3c6	g.chr5:127653964C>T	ENST00000508053.1	-	42	5569		c.e42-1		FBN2_ENST00000262464.4_Splice_Site			P35556	FBN2_HUMAN	fibrillin 2						bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			NS(1)|autonomic_ganglia(1)|biliary_tract(1)|breast(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(37)|liver(1)|lung(89)|ovary(9)|pancreas(2)|prostate(6)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	197		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		TCATCAATATCTAGGAGAAGC	0.403000													18	106					0	0	1	0	0
PXDN	7837	broad.mit.edu	37	2	1653147	1653162	+	Frame_Shift_Del	DEL	AGGGTGGTGGACACCA	AGGGTGGTGGACACCA	-			TCGA-FD-A5BR-01A-11D-A26M-08	TCGA-FD-A5BR-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afafc062-4c58-491a-8c4b-e714591ac2c2	2c6c386c-6fe4-4b77-ab2b-893aca19a3c6	g.chr2:1653147_1653162delAGGGTGGTGGACACCA	ENST00000252804.4	-	17	2440_2455	c.2390_2405delTGGTGTCCACCACCCT	c.(2389-2406)ctggtgtccaccaccctgfs	p.LVSTTL797fs		NM_012293.1	NP_036425.1	Q92626	PXDN_HUMAN	peroxidasin homolog (Drosophila)	797					extracellular matrix organization|hydrogen peroxide catabolic process|immune response	endoplasmic reticulum|extracellular space|proteinaceous extracellular matrix	extracellular matrix structural constituent|heme binding|interleukin-1 receptor antagonist activity|peroxidase activity			breast(1)|cervix(3)|endometrium(10)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(24)|lung(48)|ovary(3)|pancreas(8)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	112	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.0845)|Lung NSC(108;0.00641)|all_epithelial(98;0.00716)		all cancers(51;0.0492)|OV - Ovarian serous cystadenocarcinoma(76;0.0973)|Epithelial(75;0.17)|GBM - Glioblastoma multiforme(21;0.228)		CGTCCCGATCAGGGTGGTGGACACCAGGCGCGGCAT	0.644													19	47	---	---	---	---					
OR7E62P	26479	broad.mit.edu	37	2	71283122	71283123	+	RNA	INS	-	-	T	rs35074164		TCGA-FD-A5BR-01A-11D-A26M-08	TCGA-FD-A5BR-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afafc062-4c58-491a-8c4b-e714591ac2c2	2c6c386c-6fe4-4b77-ab2b-893aca19a3c6	g.chr2:71283122_71283123insT	ENST00000434990.1	-	0	61																											GGCACCACCCCCAGGAGTGGTG	0.530													4	6	---	---	---	---					
CTD-2503O16.4	0	broad.mit.edu	37	5	74302769	74302769	+	RNA	DEL	A	A	-			TCGA-FD-A5BR-01A-11D-A26M-08	TCGA-FD-A5BR-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afafc062-4c58-491a-8c4b-e714591ac2c2	2c6c386c-6fe4-4b77-ab2b-893aca19a3c6	g.chr5:74302769delA	ENST00000505200.1	-	0	212																											GAATAGGAGCAAAAGCTTTTA	0.418													2	4	---	---	---	---					
NKX2-6	137814	broad.mit.edu	37	8	23560351	23560351	+	Frame_Shift_Del	DEL	G	G	-			TCGA-FD-A5BR-01A-11D-A26M-08	TCGA-FD-A5BR-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afafc062-4c58-491a-8c4b-e714591ac2c2	2c6c386c-6fe4-4b77-ab2b-893aca19a3c6	g.chr8:23560351delG	ENST00000325017.3	-	2	518	c.519delC	c.(517-519)tccfs	p.S173fs	NKX2-6_ENST00000418222.1_Frame_Shift_Del_p.S91fs	NM_001136271.2	NP_001129743.2	C9JML6	C9JML6_HUMAN	NK2 homeobox 6	91						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity										TGACCTGCGTGGACGTGAGCT	0.667													2	4	---	---	---	---					
OR2S2	56656	broad.mit.edu	37	9	35957249	35957249	+	Frame_Shift_Del	DEL	G	G	-			TCGA-FD-A5BR-01A-11D-A26M-08	TCGA-FD-A5BR-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afafc062-4c58-491a-8c4b-e714591ac2c2	2c6c386c-6fe4-4b77-ab2b-893aca19a3c6	g.chr9:35957249delG	ENST00000341959.2	-	1	902	c.847delC	c.(847-849)cttfs	p.L283fs		NM_019897.2	NP_063950.2	Q9NQN1	OR2S1_HUMAN	olfactory receptor, family 2, subfamily S, member 2	283					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(2)|endometrium(2)|large_intestine(2)|lung(8)|ovary(1)|skin(1)|stomach(1)	17			LUSC - Lung squamous cell carcinoma(32;0.00613)|STAD - Stomach adenocarcinoma(86;0.194)			CCATAGAAAAGGGGGATGAGT	0.498													40	42	---	---	---	---					
MARK2	2011	broad.mit.edu	37	11	63676673	63676673	+	Frame_Shift_Del	DEL	C	C	-			TCGA-FD-A5BR-01A-11D-A26M-08	TCGA-FD-A5BR-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afafc062-4c58-491a-8c4b-e714591ac2c2	2c6c386c-6fe4-4b77-ab2b-893aca19a3c6	g.chr11:63676673delC	ENST00000402010.2	+	19	2910	c.2331delC	c.(2329-2331)aacfs	p.N777fs	MARK2_ENST00000508192.1_Frame_Shift_Del_p.N713fs|MARK2_ENST00000509502.2_Frame_Shift_Del_p.N734fs|MARK2_ENST00000350490.7_Frame_Shift_Del_p.N698fs|MARK2_ENST00000377809.4_Frame_Shift_Del_p.N762fs|MARK2_ENST00000413835.2_Frame_Shift_Del_p.N723fs|MARK2_ENST00000408948.3_Frame_Shift_Del_p.N680fs|MARK2_ENST00000315032.8_Frame_Shift_Del_p.N768fs|MARK2_ENST00000513765.2_Frame_Shift_Del_p.N744fs|MARK2_ENST00000425897.2_Frame_Shift_Del_p.N688fs|MARK2_ENST00000361128.5_Frame_Shift_Del_p.N708fs|MARK2_ENST00000377810.3_Frame_Shift_Del_p.N680fs|MARK2_ENST00000502399.3_Frame_Shift_Del_p.N767fs	NM_001039469.2	NP_001034558.2	Q7KZI7	MARK2_HUMAN	MAP/microtubule affinity-regulating kinase 2	777	KA1.				cell differentiation|establishment or maintenance of epithelial cell apical/basal polarity|intracellular protein kinase cascade|multicellular organismal development|response to oxidative stress	plasma membrane	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(13)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	33						CCTTCAAAAACATTGCCTCCA	0.627													32	84	---	---	---	---					
FAM155A	728215	broad.mit.edu	37	13	108518687	108518689	+	In_Frame_Del	DEL	CTG	CTG	-			TCGA-FD-A5BR-01A-11D-A26M-08	TCGA-FD-A5BR-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afafc062-4c58-491a-8c4b-e714591ac2c2	2c6c386c-6fe4-4b77-ab2b-893aca19a3c6	g.chr13:108518687_108518689delCTG	ENST00000375915.2	-	1	394_396	c.256_258delCAG	c.(256-258)cagdel	p.Q86del		NM_001080396.2	NP_001073865.1	B1AL88	F155A_HUMAN	family with sequence similarity 155, member A	86	Poly-Gln.					integral to membrane	binding			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(11)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	33						gccgctgcctctgctgctgctgc	0.719													8	52	---	---	---	---					
TRAV1-2	28692	broad.mit.edu	37	14	22111158	22111159	+	RNA	INS	-	-	A			TCGA-FD-A5BR-01A-11D-A26M-08	TCGA-FD-A5BR-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afafc062-4c58-491a-8c4b-e714591ac2c2	2c6c386c-6fe4-4b77-ab2b-893aca19a3c6	g.chr14:22111158_22111159insA	ENST00000390423.2	+	0	50_51																											CAGGAACTGGGAATGCAGTGCC	0.475													10	29	---	---	---	---					
MYH6	4624	broad.mit.edu	37	14	23863486	23863486	+	Frame_Shift_Del	DEL	C	C	-			TCGA-FD-A5BR-01A-11D-A26M-08	TCGA-FD-A5BR-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afafc062-4c58-491a-8c4b-e714591ac2c2	2c6c386c-6fe4-4b77-ab2b-893aca19a3c6	g.chr14:23863486delC	ENST00000405093.3	-	21	2546	c.2476delG	c.(2476-2478)gtcfs	p.V826fs	MYH6_ENST00000356287.3_Frame_Shift_Del_p.V826fs	NM_002471.3	NP_002462.2	P13533	MYH6_HUMAN	myosin, heavy chain 6, cardiac muscle, alpha	826					adult heart development|atrial cardiac muscle tissue morphogenesis|cardiac muscle fiber development|in utero embryonic development|muscle filament sliding|regulation of ATPase activity|regulation of blood pressure|regulation of heart rate|regulation of the force of heart contraction|sarcomere organization|striated muscle contraction|ventricular cardiac muscle tissue morphogenesis|visceral muscle development	cytosol|focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|protein kinase binding|structural constituent of muscle			breast(4)|cervix(2)|endometrium(8)|kidney(2)|large_intestine(16)|liver(1)|lung(60)|ovary(2)|pancreas(3)|prostate(6)|skin(6)|stomach(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	119	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00764)|READ - Rectum adenocarcinoma(4;0.0289)|Colorectal(4;0.0441)		CAATTCTTGACCCCCATGAAG	0.547													9	43	---	---	---	---					
ZNF747	65988	broad.mit.edu	37	16	30543876	30543876	+	Frame_Shift_Del	DEL	G	G	-			TCGA-FD-A5BR-01A-11D-A26M-08	TCGA-FD-A5BR-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afafc062-4c58-491a-8c4b-e714591ac2c2	2c6c386c-6fe4-4b77-ab2b-893aca19a3c6	g.chr16:30543876delG	ENST00000535210.1	-	3	1109	c.937delC	c.(937-939)ctgfs	p.L313fs	ZNF747_ENST00000252799.3_3'UTR|ZNF747_ENST00000568028.1_Frame_Shift_Del_p.L313fs|ZNF747_ENST00000569360.1_Frame_Shift_Del_p.L313fs|ZNF747_ENST00000395094.3_3'UTR			Q9BV97	ZN747_HUMAN	zinc finger protein 747	0					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding			kidney(1)|lung(3)|prostate(1)	5						GGCGGGTCCAGGTCCCCGCGG	0.647													4	9	---	---	---	---					
TP53	7157	broad.mit.edu	37	17	7574017	7574022	+	In_Frame_Del	DEL	CGCTCA	CGCTCA	-	rs121912664		TCGA-FD-A5BR-01A-11D-A26M-08	TCGA-FD-A5BR-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afafc062-4c58-491a-8c4b-e714591ac2c2	2c6c386c-6fe4-4b77-ab2b-893aca19a3c6	g.chr17:7574017_7574022delCGCTCA	ENST00000269305.4	-	10	1194_1199	c.1005_1010delTGAGCG	c.(1003-1011)cgtgagcgc>cgc	p.335_337RER>R	TP53_ENST00000413465.2_Intron|TP53_ENST00000420246.2_3'UTR|TP53_ENST00000455263.2_3'UTR|TP53_ENST00000445888.2_In_Frame_Del_p.335_337RER>R|TP53_ENST00000359597.4_Intron	NM_000546.5|NM_001126112.2|NM_001126118.1|NM_001276760.1|NM_001276761.1	NP_000537.3|NP_001119584.1|NP_001119590.1|NP_001263689.1|NP_001263690.1	P04637	P53_HUMAN	tumor protein p53	335	Interaction with CARM1.|Interaction with HIPK1 (By similarity).|Interaction with HIPK2.|Oligomerization.		R -> G (in a sporadic cancer; somatic mutation).|R -> H (in a sporadic cancer; somatic mutation).|R -> L (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R337C(18)|p.R337L(15)|p.0?(8)|p.E336*(5)|p.R337H(4)|p.R337fs*8(2)|p.R337G(1)|p.?(1)|p.E336fs*12(1)|p.I332fs*5(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CATCTCGAAGCGCTCACGCCCACGGA	0.524		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			7	17	---	---	---	---					
MYH4	4622	broad.mit.edu	37	17	10356182	10356185	+	Frame_Shift_Del	DEL	TCCA	TCCA	-			TCGA-FD-A5BR-01A-11D-A26M-08	TCGA-FD-A5BR-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afafc062-4c58-491a-8c4b-e714591ac2c2	2c6c386c-6fe4-4b77-ab2b-893aca19a3c6	g.chr17:10356182_10356185delTCCA	ENST00000255381.2	-	25	3286_3289	c.3176_3179delTGGA	c.(3175-3180)ctggagfs	p.LE1059fs	RP11-799N11.1_ENST00000581304.1_RNA|RP11-799N11.1_ENST00000399342.2_RNA|CTC-297N7.11_ENST00000587182.2_RNA	NM_017533.2	NP_060003.2	Q9Y623	MYH4_HUMAN	myosin, heavy chain 4, skeletal muscle	1059					muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(4)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(13)|lung(72)|ovary(10)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	149						TAGGTCACCCTCCAGTTTTCTCTT	0.348													38	43	---	---	---	---					
SLC8A2	6543	broad.mit.edu	37	19	47935681	47935683	+	In_Frame_Del	DEL	TCC	TCC	-			TCGA-FD-A5BR-01A-11D-A26M-08	TCGA-FD-A5BR-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afafc062-4c58-491a-8c4b-e714591ac2c2	2c6c386c-6fe4-4b77-ab2b-893aca19a3c6	g.chr19:47935681_47935683delTCC	ENST00000236877.6	-	9	2525_2527	c.2130_2132delGGA	c.(2128-2133)gaggac>gac	p.E710del	SLC8A2_ENST00000601757.1_5'UTR|SLC8A2_ENST00000542837.1_In_Frame_Del_p.E466del|SLC8A2_ENST00000539381.1_In_Frame_Del_p.E173del	NM_015063.2	NP_055878.1	Q9UPR5	NAC2_HUMAN	solute carrier family 8 (sodium/calcium exchanger), member 2	710					cell communication|platelet activation	integral to membrane|plasma membrane	calcium:sodium antiporter activity|calmodulin binding			breast(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(10)|ovary(2)|prostate(2)|skin(5)|stomach(1)	31		all_cancers(25;3.05e-07)|all_lung(116;4.19e-06)|Lung NSC(112;7.16e-06)|all_epithelial(76;7.65e-06)|all_neural(266;0.0652)|Ovarian(192;0.086)|Breast(70;0.173)		OV - Ovarian serous cystadenocarcinoma(262;0.000501)|all cancers(93;0.00058)|Epithelial(262;0.0181)|GBM - Glioblastoma multiforme(486;0.0457)		CCGGGACCCGTCCTCCTCCTCCT	0.616													7	153	---	---	---	---					
TBC1D20	128637	broad.mit.edu	37	20	419255	419265	+	Frame_Shift_Del	DEL	TTAGGGGCCCA	TTAGGGGCCCA	-			TCGA-FD-A5BR-01A-11D-A26M-08	TCGA-FD-A5BR-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afafc062-4c58-491a-8c4b-e714591ac2c2	2c6c386c-6fe4-4b77-ab2b-893aca19a3c6	g.chr20:419255_419265delTTAGGGGCCCA	ENST00000354200.4	-	8	1324_1334	c.1177_1187delTGGGCCCCTAA	c.(1177-1188)tgggcccctaagfs	p.WAPK393fs	TBC1D20_ENST00000461188.1_5'UTR	NM_144628.2	NP_653229.1	Q96BZ9	TBC20_HUMAN	TBC1 domain family, member 20	393					interspecies interaction between organisms	integral to membrane|intracellular	Rab GTPase activator activity	p.W393L(1)		central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(2)|skin(1)|upper_aerodigestive_tract(1)	12		all_epithelial(17;0.228)|Breast(17;0.231)				CAGCTGAAACTTAGGGGCCCATTCCAGGGCA	0.536													15	119	---	---	---	---					
LINC00162	378825	broad.mit.edu	37	21	46421847	46421852	+	RNA	DEL	CAGCCC	CAGCCC	-	rs881968	by1000genomes	TCGA-FD-A5BR-01A-11D-A26M-08	TCGA-FD-A5BR-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afafc062-4c58-491a-8c4b-e714591ac2c2	2c6c386c-6fe4-4b77-ab2b-893aca19a3c6	g.chr21:46421847_46421852delCAGCCC	ENST00000422199.1	-	0	284					NR_024089.1																						ACGACTGTGTCAgcccctgcccctgc	0.665													3	3	---	---	---	---