Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
PLCE1	51196	broad.mit.edu	37	10	96005737	96005737	+	Missense_Mutation	SNP	G	G	A			TCGA-K4-A4AB-01B-12D-A289-08	TCGA-K4-A4AB-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4b6e6192-477f-484a-bfe6-811d252fcc92	71d2241d-fa8b-4e1d-8f55-fdff8143f572	g.chr10:96005737G>A	ENST00000371380.3	+	7	2690	c.2455G>A	c.(2455-2457)Gac>Aac	p.D819N	PLCE1_ENST00000371385.3_Missense_Mutation_p.D511N|PLCE1_ENST00000371375.1_Missense_Mutation_p.D511N|PLCE1_ENST00000260766.3_Missense_Mutation_p.D819N			Q9P212	PLCE1_HUMAN	phospholipase C, epsilon 1						activation of MAPK activity|activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|calcium-mediated signaling|cell proliferation|cytoskeleton organization|diacylglycerol biosynthetic process|elevation of cytosolic calcium ion concentration|epidermal growth factor receptor signaling pathway|glomerulus development|heart development|lipid catabolic process|Ras protein signal transduction|regulation of cell growth|regulation of G-protein coupled receptor protein signaling pathway|regulation of Ras protein signal transduction|regulation of smooth muscle contraction	cytosol|Golgi membrane|membrane fraction|plasma membrane	calcium ion binding|guanyl-nucleotide exchange factor activity|phosphatidylinositol phospholipase C activity|Ras GTPase binding|receptor signaling protein activity			liver(1)|ovary(2)|skin(4)|upper_aerodigestive_tract(1)	8		Colorectal(252;0.0458)				TTCAGACAATGACATCTTTGA	0.418000													25	75					0	0	1	0	0
FAM193A	8603	broad.mit.edu	37	4	2717761	2717761	+	Silent	SNP	C	C	T			TCGA-K4-A4AB-01B-12D-A289-08	TCGA-K4-A4AB-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4b6e6192-477f-484a-bfe6-811d252fcc92	71d2241d-fa8b-4e1d-8f55-fdff8143f572	g.chr4:2717761C>T	ENST00000324666.5	+	19	3985	c.3634C>T	c.(3634-3636)Cta>Tta	p.L1212L	FAM193A_ENST00000505311.1_Silent_p.L1171L|FAM193A_ENST00000502458.1_Silent_p.L1193L|FAM193A_ENST00000382839.3_Silent_p.L1171L|FAM193A_ENST00000545951.1_Silent_p.L1171L	NM_001256666.1	NP_001243595.1	P78312	F193A_HUMAN	family with sequence similarity 193, member A	1212										NS(2)|breast(1)|endometrium(4)|kidney(4)|large_intestine(3)|lung(12)|ovary(4)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(3)	40						TGATGTCTTTCTACCTAAAGA	0.393000													20	42					0	0	1	0	0
GHSR	2693	broad.mit.edu	37	3	172165522	172165522	+	Missense_Mutation	SNP	G	G	A			TCGA-K4-A4AB-01B-12D-A289-08	TCGA-K4-A4AB-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4b6e6192-477f-484a-bfe6-811d252fcc92	71d2241d-fa8b-4e1d-8f55-fdff8143f572	g.chr3:172165522G>A	ENST00000241256.2	-	1	724	c.682C>T	c.(682-684)Ctc>Ttc	p.L228F	GHSR_ENST00000427970.1_Missense_Mutation_p.L228F	NM_198407.2	NP_940799.1	Q92847	GHSR_HUMAN	growth hormone secretagogue receptor	228					actin polymerization or depolymerization|adult feeding behavior|decidualization|growth hormone secretion|hormone-mediated signaling pathway|negative regulation of inflammatory response|negative regulation of interleukin-1 beta production|negative regulation of interleukin-6 biosynthetic process|negative regulation of tumor necrosis factor biosynthetic process|positive regulation of appetite|positive regulation of multicellular organism growth	cell surface|integral to membrane|membrane raft|neuron projection|plasma membrane	growth hormone secretagogue receptor activity|growth hormone-releasing hormone receptor activity			biliary_tract(1)|breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(6)|lung(16)|ovary(2)|prostate(3)|skin(1)|urinary_tract(1)	33	Ovarian(172;0.00143)|Breast(254;0.197)		Lung(28;3.93e-15)|LUSC - Lung squamous cell carcinoma(14;1.48e-14)|STAD - Stomach adenocarcinoma(35;0.235)			AGGACCGTGAGACAGAAGACA	0.612000													25	73					0	0	1	0	0
PHB2	11331	broad.mit.edu	37	12	7077741	7077741	+	Missense_Mutation	SNP	T	T	C			TCGA-K4-A4AB-01B-12D-A289-08	TCGA-K4-A4AB-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4b6e6192-477f-484a-bfe6-811d252fcc92	71d2241d-fa8b-4e1d-8f55-fdff8143f572	g.chr12:7077741T>C	ENST00000535923.1	-	4	591	c.310A>G	c.(310-312)Atc>Gtc	p.I104V	PHB2_ENST00000544134.1_5'UTR|PHB2_ENST00000440277.1_Missense_Mutation_p.I104V|PHB2_ENST00000399433.2_Missense_Mutation_p.I104V|PHB2_ENST00000542912.1_Missense_Mutation_p.I104V|PHB2_ENST00000546111.1_Intron	NM_001144831.1	NP_001138303.1	Q99623	PHB2_HUMAN	prohibitin 2	104					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrial inner membrane|nucleus	estrogen receptor binding|receptor activity			ovary(2)|pancreas(1)	3						CGCAGGGAGATATTCACCATC	0.532000													12	23					0	0	1	0	0
RANBP17	64901	broad.mit.edu	37	5	170395287	170395287	+	Missense_Mutation	SNP	G	G	T			TCGA-K4-A4AB-01B-12D-A289-08	TCGA-K4-A4AB-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4b6e6192-477f-484a-bfe6-811d252fcc92	71d2241d-fa8b-4e1d-8f55-fdff8143f572	g.chr5:170395287G>T	ENST00000523189.1	+	14	1780	c.1616G>T	c.(1615-1617)cGa>cTa	p.R539L		NM_022897.3	NP_075048.1	Q9H2T7	RBP17_HUMAN	RAN binding protein 17	539					mRNA transport|protein import into nucleus|transmembrane transport	cytoplasm|nuclear pore	GTP binding|protein transporter activity			breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(25)|ovary(3)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	50	Renal(175;0.000159)|Lung NSC(126;0.00751)|all_lung(126;0.0123)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			GGATTGCCTCGATGTTGTAAT	0.343000			T	TRD@	ALL								3	37					1	1	1	1	0
WASH3P	374666	broad.mit.edu	37	15	102516511	102516511	+	RNA	SNP	C	C	T			TCGA-K4-A4AB-01B-12D-A289-08	TCGA-K4-A4AB-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4b6e6192-477f-484a-bfe6-811d252fcc92	71d2241d-fa8b-4e1d-8f55-fdff8143f572	g.chr15:102516511C>T	ENST00000557932.1	+	0	1459																				central_nervous_system(1)|endometrium(6)|kidney(11)|prostate(5)|stomach(1)|urinary_tract(1)	25						AGACTTGGGCCGTTGCTCTGA	0.627000													3	38					0	0	1	0	0
HDAC5	10014	broad.mit.edu	37	17	42156557	42156557	+	Silent	SNP	G	G	A			TCGA-K4-A4AB-01B-12D-A289-08	TCGA-K4-A4AB-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4b6e6192-477f-484a-bfe6-811d252fcc92	71d2241d-fa8b-4e1d-8f55-fdff8143f572	g.chr17:42156557G>A	ENST00000225983.6	-	24	3359	c.3036C>T	c.(3034-3036)atC>atT	p.I1012I	HDAC5_ENST00000336057.5_Silent_p.I926I|HDAC5_ENST00000393622.2_Silent_p.I1011I|HDAC5_ENST00000586802.1_Silent_p.I1011I			Q9UQL6	HDAC5_HUMAN	histone deacetylase 5	1011	Histone deacetylase.				B cell differentiation|cellular response to insulin stimulus|chromatin remodeling|chromatin silencing|inflammatory response|negative regulation of cell migration involved in sprouting angiogenesis|negative regulation of myotube differentiation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of protein binding|transcription, DNA-dependent	cytoplasm|histone deacetylase complex	histone deacetylase activity (H3-K16 specific)|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|protein kinase C binding|repressing transcription factor binding			central_nervous_system(1)|endometrium(5)|large_intestine(4)|lung(7)|ovary(1)|prostate(2)|skin(1)	21		Breast(137;0.00637)|Prostate(33;0.0313)		BRCA - Breast invasive adenocarcinoma(366;0.118)		AGGCATCACAGATGGCGGTCA	0.632000													17	28					0	0	1	0	0
DRP2	1821	broad.mit.edu	37	X	100492731	100492731	+	Silent	SNP	G	G	A			TCGA-K4-A4AB-01B-12D-A289-08	TCGA-K4-A4AB-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4b6e6192-477f-484a-bfe6-811d252fcc92	71d2241d-fa8b-4e1d-8f55-fdff8143f572	g.chrX:100492731G>A	ENST00000395209.3	+	5	932	c.405G>A	c.(403-405)gtG>gtA	p.V135V	DRP2_ENST00000541709.1_Silent_p.V57V|DRP2_ENST00000402866.1_Silent_p.V135V|DRP2_ENST00000538510.1_Silent_p.V135V	NM_001939.2	NP_001930.2	Q13474	DRP2_HUMAN	dystrophin related protein 2	135					central nervous system development	cytoplasm|cytoskeleton	zinc ion binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(10)|lung(10)|ovary(3)|prostate(1)|skin(2)|urinary_tract(2)	31						AGGGGGATGTGGCCCTGGTGC	0.537000													77	17					0	0	1	0	0
BLMH	642	broad.mit.edu	37	17	28599906	28599906	+	Silent	SNP	C	C	G			TCGA-K4-A4AB-01B-12D-A289-08	TCGA-K4-A4AB-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4b6e6192-477f-484a-bfe6-811d252fcc92	71d2241d-fa8b-4e1d-8f55-fdff8143f572	g.chr17:28599906C>G	ENST00000261714.6	-	8	987	c.813G>C	c.(811-813)gtG>gtC	p.V271V	BLMH_ENST00000394819.3_Silent_p.V184V	NM_000386.3	NP_000377.1	Q13867	BLMH_HUMAN	bleomycin hydrolase	271					proteolysis	cytoplasm|nucleus	aminopeptidase activity|carboxypeptidase activity|cysteine-type endopeptidase activity|protein binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(2)|ovary(1)|prostate(1)|stomach(1)	13						TAGGGTCATTCACTAAACAAA	0.408000													32	68					0	0	1	0	0
SLC27A4	10999	broad.mit.edu	37	9	131117338	131117338	+	Missense_Mutation	SNP	C	C	T			TCGA-K4-A4AB-01B-12D-A289-08	TCGA-K4-A4AB-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4b6e6192-477f-484a-bfe6-811d252fcc92	71d2241d-fa8b-4e1d-8f55-fdff8143f572	g.chr9:131117338C>T	ENST00000300456.4	+	10	1448	c.1331C>T	c.(1330-1332)cCg>cTg	p.P444L	SLC27A4_ENST00000372870.1_Intron	NM_005094.3	NP_005085.2	Q6P1M0	S27A4_HUMAN	solute carrier family 27 (fatty acid transporter), member 4						long-chain fatty acid transport|transmembrane transport	integral to membrane	fatty acid transporter activity|nucleotide binding|protein binding			autonomic_ganglia(1)|kidney(1)|large_intestine(1)|lung(7)|ovary(1)|prostate(2)	13						CCAGGTGAGCCGGGCCAGCTG	0.587000													3	17					0	0	1	0	0
TBC1D23	55773	broad.mit.edu	37	3	100023715	100023715	+	Missense_Mutation	SNP	C	C	A			TCGA-K4-A4AB-01B-12D-A289-08	TCGA-K4-A4AB-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4b6e6192-477f-484a-bfe6-811d252fcc92	71d2241d-fa8b-4e1d-8f55-fdff8143f572	g.chr3:100023715C>A	ENST00000394144.4	+	12	1296	c.1289C>A	c.(1288-1290)gCc>gAc	p.A430D	TBC1D23_ENST00000344949.5_Missense_Mutation_p.A430D|TBC1D23_ENST00000475134.1_Missense_Mutation_p.A293D|TBC1D23_ENST00000486274.1_3'UTR	NM_001199198.2	NP_001186127.1	Q9NUY8	TBC23_HUMAN	TBC1 domain family, member 23	430	Rhodanese.					intracellular	Rab GTPase activator activity			breast(1)|endometrium(1)|large_intestine(7)|liver(1)|lung(10)|ovary(1)|prostate(2)|skin(2)	25						GTGAGTATTGCCAGTGGAGGA	0.294000													4	17					0.00116845	0.00119262	1	1	0
MYO7A	4647	broad.mit.edu	37	11	76893106	76893106	+	Missense_Mutation	SNP	C	C	T	rs113326082		TCGA-K4-A4AB-01B-12D-A289-08	TCGA-K4-A4AB-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4b6e6192-477f-484a-bfe6-811d252fcc92	71d2241d-fa8b-4e1d-8f55-fdff8143f572	g.chr11:76893106C>T	ENST00000409709.3	+	24	3286	c.3014C>T	c.(3013-3015)gCg>gTg	p.A1005V	MYO7A_ENST00000409893.1_Missense_Mutation_p.A1005V|MYO7A_ENST00000409619.2_Missense_Mutation_p.A994V|MYO7A_ENST00000458637.2_Missense_Mutation_p.A1005V	NM_000260.3	NP_000251.3	Q13402	MYO7A_HUMAN	myosin VIIA	1005					actin filament-based movement|equilibrioception|lysosome organization|sensory perception of sound|visual perception	cytosol|lysosomal membrane|myosin complex|photoreceptor inner segment|photoreceptor outer segment|synapse	actin binding|ATP binding|calmodulin binding|microfilament motor activity			NS(2)|breast(2)|central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(10)|lung(32)|ovary(4)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	64						GCCAAGTTCGCGGCCACCTAC	0.612000													25	120					0	0	1	0	0
DNTT	1791	broad.mit.edu	37	10	98079147	98079147	+	Splice_Site	SNP	G	G	A			TCGA-K4-A4AB-01B-12D-A289-08	TCGA-K4-A4AB-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4b6e6192-477f-484a-bfe6-811d252fcc92	71d2241d-fa8b-4e1d-8f55-fdff8143f572	g.chr10:98079147G>A	ENST00000419175.1	+	3	677	c.507G>A	c.(505-507)acG>acA	p.T169T	DNTT_ENST00000371174.2_Splice_Site_p.T169T	NM_001017520.1|NM_004088.3	NP_001017520.1|NP_004079.3	P04053	TDT_HUMAN	DNA nucleotidylexotransferase	169	Mediates interaction with DNTTIP2.				DNA modification	nucleus	DNA binding|DNA nucleotidylexotransferase activity|DNA-directed DNA polymerase activity|metal ion binding			NS(1)|breast(1)|endometrium(3)|kidney(2)|large_intestine(8)|lung(6)|ovary(2)|prostate(1)|skin(2)|urinary_tract(1)	27		Colorectal(252;0.0815)|all_hematologic(284;0.224)		Epithelial(162;7.97e-08)|all cancers(201;1.89e-06)		AGATATTCACGGTAACGGGAC	0.448000													53	114					0	0	1	0	0
OBSCN	84033	broad.mit.edu	37	1	228482592	228482592	+	Missense_Mutation	SNP	G	G	A			TCGA-K4-A4AB-01B-12D-A289-08	TCGA-K4-A4AB-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4b6e6192-477f-484a-bfe6-811d252fcc92	71d2241d-fa8b-4e1d-8f55-fdff8143f572	g.chr1:228482592G>A	ENST00000570156.2	+	48	12868	c.12794G>A	c.(12793-12795)gGg>gAg	p.G4265E	OBSCN_ENST00000359599.6_Missense_Mutation_p.G2683E|OBSCN_ENST00000366707.4_Missense_Mutation_p.G955E|OBSCN_ENST00000422127.1_Missense_Mutation_p.G3836E|OBSCN_ENST00000284548.11_Missense_Mutation_p.G3836E|OBSCN_ENST00000366709.4_Missense_Mutation_p.G955E	NM_001271223.2	NP_001258152.2	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	3308	Ig-like 44.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			NS(2)|breast(7)|central_nervous_system(5)|cervix(2)|endometrium(30)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(37)|lung(89)|ovary(8)|pancreas(3)|prostate(13)|skin(6)|stomach(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	223		Prostate(94;0.0405)				TGGAGGAAGGGGTCTGAGACC	0.592000													93	177					0	0	1	0	0
ZFP2	80108	broad.mit.edu	37	5	178358366	178358366	+	Missense_Mutation	SNP	A	A	G			TCGA-K4-A4AB-01B-12D-A289-08	TCGA-K4-A4AB-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4b6e6192-477f-484a-bfe6-811d252fcc92	71d2241d-fa8b-4e1d-8f55-fdff8143f572	g.chr5:178358366A>G	ENST00000361362.2	+	5	582	c.52A>G	c.(52-54)Aat>Gat	p.N18D	ZFP2_ENST00000520301.1_Missense_Mutation_p.N18D|ZFP2_ENST00000503510.2_Missense_Mutation_p.N18D|ZFP2_ENST00000523286.1_Missense_Mutation_p.N18D	NM_030613.2	NP_085116.2	Q6ZN57	ZFP2_HUMAN	ZFP2 zinc finger protein	18					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|endometrium(2)|kidney(1)|large_intestine(7)|liver(1)|lung(2)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|stomach(1)	20	all_cancers(89;0.000639)|all_epithelial(37;0.000109)|Renal(175;0.000159)|Lung NSC(126;0.00199)|all_lung(126;0.00351)	all_neural(177;0.00802)|Medulloblastoma(196;0.0145)|all_hematologic(541;0.248)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.00655)|GBM - Glioblastoma multiforme(465;0.0302)|OV - Ovarian serous cystadenocarcinoma(192;0.0615)|Epithelial(171;0.111)		CTGGGAACCTAATAATTGGTT	0.453000													43	45					0	0	1	0	0
ZMIZ1	57178	broad.mit.edu	37	10	81058181	81058181	+	Missense_Mutation	SNP	G	G	T			TCGA-K4-A4AB-01B-12D-A289-08	TCGA-K4-A4AB-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4b6e6192-477f-484a-bfe6-811d252fcc92	71d2241d-fa8b-4e1d-8f55-fdff8143f572	g.chr10:81058181G>T	ENST00000334512.5	+	15	2082	c.1510G>T	c.(1510-1512)Gtg>Ttg	p.V504L		NM_020338.3	NP_065071.1	Q9ULJ6	ZMIZ1_HUMAN	zinc finger, MIZ-type containing 1	504	Pro-rich.				transcription, DNA-dependent	cytoplasm|nuclear speck	zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(14)|ovary(2)|prostate(3)|skin(1)	30	all_cancers(46;0.0292)|Breast(12;8.52e-05)|all_epithelial(25;0.000854)|Prostate(51;0.00985)		Epithelial(14;0.00256)|all cancers(16;0.00726)|Colorectal(32;0.229)			GCCGGTTCCTGTGGCAAATTA	0.587000													92	180					4.64247e-43	5.32624e-43	1	1	0
AKAP12	9590	broad.mit.edu	37	6	151673794	151673794	+	Missense_Mutation	SNP	C	C	A			TCGA-K4-A4AB-01B-12D-A289-08	TCGA-K4-A4AB-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4b6e6192-477f-484a-bfe6-811d252fcc92	71d2241d-fa8b-4e1d-8f55-fdff8143f572	g.chr6:151673794C>A	ENST00000402676.2	+	4	4508	c.4268C>A	c.(4267-4269)gCg>gAg	p.A1423E	AKAP12_ENST00000253332.1_Missense_Mutation_p.A1423E|AKAP12_ENST00000359755.5_Missense_Mutation_p.A1318E|AKAP12_ENST00000354675.6_Missense_Mutation_p.A1325E	NM_005100.3	NP_005091.2	Q02952	AKA12_HUMAN	A kinase (PRKA) anchor protein 12	1423					G-protein coupled receptor protein signaling pathway|positive regulation of cAMP biosynthetic process|positive regulation of protein kinase A signaling cascade|protein targeting	cell cortex|cytoskeleton|plasma membrane	adenylate cyclase binding|protein kinase A binding			breast(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(22)|lung(22)|ovary(2)|pancreas(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	68		Ovarian(120;0.125)	BRCA - Breast invasive adenocarcinoma(37;0.175)	OV - Ovarian serous cystadenocarcinoma(155;2.98e-11)		ACTCTAACAGCGGCTGCAGAG	0.483000													44	50					1.61572e-30	1.83944e-30	1	1	0
IGLV4-69	28784	broad.mit.edu	37	22	22385848	22385848	+	RNA	SNP	C	C	T			TCGA-K4-A4AB-01B-12D-A289-08	TCGA-K4-A4AB-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4b6e6192-477f-484a-bfe6-811d252fcc92	71d2241d-fa8b-4e1d-8f55-fdff8143f572	g.chr22:22385848C>T	ENST00000390282.2	+	0	397				PRAMENP_ENST00000337471.4_RNA																							CTATTACTGTCAGACCTGGGG	0.542000													23	53					0	0	1	0	0
CNTNAP2	26047	broad.mit.edu	37	7	146805381	146805381	+	Silent	SNP	G	G	A			TCGA-K4-A4AB-01B-12D-A289-08	TCGA-K4-A4AB-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4b6e6192-477f-484a-bfe6-811d252fcc92	71d2241d-fa8b-4e1d-8f55-fdff8143f572	g.chr7:146805381G>A	ENST00000361727.3	+	5	1209	c.693G>A	c.(691-693)caG>caA	p.Q231Q		NM_014141.5	NP_054860.1	Q9UHC6	CNTP2_HUMAN	contactin associated protein-like 2	231	Laminin G-like 1.				behavior|cell adhesion|clustering of voltage-gated potassium channels|limbic system development|neuron recognition|signal transduction|striatum development|superior temporal gyrus development|thalamus development|transmission of nerve impulse	axolemma|cell body fiber|dendrite|juxtaparanode region of axon|voltage-gated potassium channel complex	receptor binding			NS(3)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(21)|lung(105)|ovary(9)|pancreas(2)|prostate(5)|skin(7)|stomach(3)|upper_aerodigestive_tract(6)|urinary_tract(3)	188	Melanoma(164;0.153)	all_cancers(3;3.51e-10)|all_epithelial(3;1.4e-05)|Myeloproliferative disorder(3;0.00452)|Lung NSC(3;0.0067)|all_lung(3;0.00794)	OV - Ovarian serous cystadenocarcinoma(82;0.0319)			GAGAAGGACAGCAAGGAGATT	0.398000										HNSCC(39;0.1)			11	35					0	0	1	0	0
CAMK1D	57118	broad.mit.edu	37	10	12858264	12858264	+	Missense_Mutation	SNP	G	G	A			TCGA-K4-A4AB-01B-12D-A289-08	TCGA-K4-A4AB-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4b6e6192-477f-484a-bfe6-811d252fcc92	71d2241d-fa8b-4e1d-8f55-fdff8143f572	g.chr10:12858264G>A	ENST00000378847.3	+	8	1107	c.770G>A	c.(769-771)cGg>cAg	p.R257Q	CAMK1D_ENST00000378845.1_Missense_Mutation_p.R257Q	NM_153498.2	NP_705718.1	Q8IU85	KCC1D_HUMAN	calcium/calmodulin-dependent protein kinase ID	257	Protein kinase.					calcium- and calmodulin-dependent protein kinase complex|cytoplasm|nucleus	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			endometrium(3)|kidney(2)|large_intestine(4)|lung(4)|ovary(1)|skin(1)|stomach(1)	16				GBM - Glioblastoma multiforme(1;3.16e-05)		GACTTCATTCGGAACCTGATG	0.498000													23	45					0	0	1	0	0
MAPT	4137	broad.mit.edu	37	17	44055782	44055782	+	Missense_Mutation	SNP	G	G	A			TCGA-K4-A4AB-01B-12D-A289-08	TCGA-K4-A4AB-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4b6e6192-477f-484a-bfe6-811d252fcc92	71d2241d-fa8b-4e1d-8f55-fdff8143f572	g.chr17:44055782G>A	ENST00000344290.5	+	5	671	c.349G>A	c.(349-351)Gaa>Aaa	p.E117K	MAPT_ENST00000574436.1_Missense_Mutation_p.E117K|MAPT_ENST00000420682.2_Missense_Mutation_p.E88K|MAPT_ENST00000431008.3_Missense_Mutation_p.E117K|MAPT_ENST00000262410.5_Missense_Mutation_p.E117K|MAPT_ENST00000415613.2_Missense_Mutation_p.E117K|MAPT_ENST00000334239.8_Missense_Mutation_p.E59K|MAPT_ENST00000351559.5_Missense_Mutation_p.E117K|MAPT_ENST00000571987.1_Missense_Mutation_p.E117K|MAPT_ENST00000570299.1_3'UTR|MAPT_ENST00000347967.5_Missense_Mutation_p.E23K|MAPT_ENST00000576518.1_Missense_Mutation_p.E48K|MAPT_ENST00000446361.3_Missense_Mutation_p.E59K|MAPT_ENST00000340799.5_Missense_Mutation_p.E88K|MAPT_ENST00000535772.1_Missense_Mutation_p.E117K	NM_001123066.3	NP_001116538.2	P10636	TAU_HUMAN	microtubule-associated protein tau	117					cellular component disassembly involved in apoptosis|microtubule cytoskeleton organization|negative regulation of microtubule depolymerization|positive regulation of axon extension|positive regulation of microtubule polymerization|regulation of autophagy	axon|cytosol|growth cone|microtubule|microtubule associated complex|nuclear periphery|plasma membrane|tubulin complex	apolipoprotein E binding|enzyme binding|identical protein binding|lipoprotein particle binding|microtubule binding|protein binding|SH3 domain binding|structural constituent of cytoskeleton			breast(1)|endometrium(4)|kidney(1)|large_intestine(9)|lung(14)|ovary(2)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	38		Melanoma(429;0.216)				CCTGGAAGACGAAGCTGCTGG	0.537000													32	62					0	0	1	0	0
RRN3P2	653390	broad.mit.edu	37	16	29110458	29110458	+	RNA	SNP	T	T	C	rs151074589	by1000genomes	TCGA-K4-A4AB-01B-12D-A289-08	TCGA-K4-A4AB-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4b6e6192-477f-484a-bfe6-811d252fcc92	71d2241d-fa8b-4e1d-8f55-fdff8143f572	g.chr16:29110458T>C	ENST00000564580.1	+	0	1131																		p.W375R(25)									GAATTTTGAGTGGATAGTGAT	0.328000													5	49					0	0	1	0	0
TRAM1L1	133022	broad.mit.edu	37	4	118006125	118006125	+	Missense_Mutation	SNP	G	G	C			TCGA-K4-A4AB-01B-12D-A289-08	TCGA-K4-A4AB-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4b6e6192-477f-484a-bfe6-811d252fcc92	71d2241d-fa8b-4e1d-8f55-fdff8143f572	g.chr4:118006125G>C	ENST00000310754.4	-	1	611	c.425C>G	c.(424-426)tCt>tGt	p.S142C		NM_152402.2	NP_689615.2	Q8N609	TR1L1_HUMAN	translocation associated membrane protein 1-like 1	142	TLC.				protein transport|transmembrane transport	endoplasmic reticulum membrane|integral to membrane				central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(10)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	22						GCAGTTTTCAGAGATTAAAAT	0.388000													29	76					0	0	1	0	0
AFF4	27125	broad.mit.edu	37	5	132232119	132232119	+	Missense_Mutation	SNP	C	C	T			TCGA-K4-A4AB-01B-12D-A289-08	TCGA-K4-A4AB-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4b6e6192-477f-484a-bfe6-811d252fcc92	71d2241d-fa8b-4e1d-8f55-fdff8143f572	g.chr5:132232119C>T	ENST00000265343.5	-	11	2582	c.2203G>A	c.(2203-2205)Gag>Aag	p.E735K	AFF4_ENST00000378595.3_Missense_Mutation_p.E735K	NM_014423.3	NP_055238.1	Q9UHB7	AFF4_HUMAN	AF4/FMR2 family, member 4	735					transcription from RNA polymerase II promoter	mitochondrion|nucleolus	protein binding|sequence-specific DNA binding transcription factor activity		SEPT8/AFF4(2)	breast(2)|central_nervous_system(2)|endometrium(6)|kidney(6)|large_intestine(7)|lung(11)|ovary(3)|pancreas(1)|prostate(3)|skin(2)	43		all_cancers(142;0.145)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			TTGGGCGGCTCTGTTTCTTTG	0.453000													40	59					0	0	1	0	0
KDM6B	23135	broad.mit.edu	37	17	7756685	7756685	+	Missense_Mutation	SNP	A	A	G			TCGA-K4-A4AB-01B-12D-A289-08	TCGA-K4-A4AB-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4b6e6192-477f-484a-bfe6-811d252fcc92	71d2241d-fa8b-4e1d-8f55-fdff8143f572	g.chr17:7756685A>G	ENST00000254846.5	+	22	5284	c.4895A>G	c.(4894-4896)gAc>gGc	p.D1632G	KDM6B_ENST00000448097.2_Missense_Mutation_p.D1632G	NM_001080424.1	NP_001073893.1	O15054	KDM6B_HUMAN	lysine (K)-specific demethylase 6B	1632					inflammatory response	nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			central_nervous_system(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(3)|lung(18)|ovary(1)|pancreas(1)|skin(5)	37						CAGGCCTACGACGCCTTCACG	0.746000													3	10					0	0	1	0	0
TMTC4	84899	broad.mit.edu	37	13	101294500	101294500	+	Missense_Mutation	SNP	C	C	T			TCGA-K4-A4AB-01B-12D-A289-08	TCGA-K4-A4AB-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4b6e6192-477f-484a-bfe6-811d252fcc92	71d2241d-fa8b-4e1d-8f55-fdff8143f572	g.chr13:101294500C>T	ENST00000342624.5	-	7	964	c.706G>A	c.(706-708)Gcc>Acc	p.A236T	TMTC4_ENST00000462211.1_5'UTR|TMTC4_ENST00000328767.5_Missense_Mutation_p.A106T|TMTC4_ENST00000376234.3_Missense_Mutation_p.A217T	NM_032813.2	NP_116202.2	Q5T4D3	TMTC4_HUMAN	transmembrane and tetratricopeptide repeat containing 4	217						integral to membrane	binding			breast(3)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(5)|liver(1)|lung(14)|ovary(2)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	34	all_neural(89;0.0837)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)					CACAGCATGGCCACTGCTCCC	0.502000													96	103					0	0	1	0	0
ERVW-1	30816	broad.mit.edu	37	7	92099563	92099563	+	Missense_Mutation	SNP	C	C	T			TCGA-K4-A4AB-01B-12D-A289-08	TCGA-K4-A4AB-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4b6e6192-477f-484a-bfe6-811d252fcc92	71d2241d-fa8b-4e1d-8f55-fdff8143f572	g.chr7:92099563C>T	ENST00000493463.2	-	1	1056	c.133G>A	c.(133-135)Gga>Aga	p.G45R	AC007566.10_ENST00000427458.1_RNA|ERVW-1_ENST00000603053.1_Missense_Mutation_p.G45R|ERVW-1_ENST00000604270.1_Intron	NM_014590.3	NP_055405.3	Q9UQF0	ENW1_HUMAN		45					syncytium formation	integral to membrane|plasma membrane|virion				endometrium(1)|large_intestine(1)|lung(15)	17						tcaatatttccgggacgctgc	0.522000													73	104					0	0	1	0	0
FUT4	2526	broad.mit.edu	37	11	94277903	94277903	+	Missense_Mutation	SNP	G	G	A			TCGA-K4-A4AB-01B-12D-A289-08	TCGA-K4-A4AB-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4b6e6192-477f-484a-bfe6-811d252fcc92	71d2241d-fa8b-4e1d-8f55-fdff8143f572	g.chr11:94277903G>A	ENST00000358752.2	+	1	887	c.604G>A	c.(604-606)Gat>Aat	p.D202N		NM_002033.3	NP_002024.1	P22083	FUT4_HUMAN	fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific)	202					L-fucose catabolic process|protein glycosylation	Golgi cisterna membrane|integral to membrane|membrane fraction	alpha(1,3)-fucosyltransferase activity			central_nervous_system(2)|endometrium(2)|lung(1)|skin(2)|upper_aerodigestive_tract(1)	8		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)				CGGGGGGCGCGATAGCGCCCC	0.746000													16	20					0	0	1	0	0
SNORD114-3	767579	broad.mit.edu	37	14	101419750	101419750	+	RNA	SNP	C	C	T			TCGA-K4-A4AB-01B-12D-A289-08	TCGA-K4-A4AB-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4b6e6192-477f-484a-bfe6-811d252fcc92	71d2241d-fa8b-4e1d-8f55-fdff8143f572	g.chr14:101419750C>T	ENST00000364969.1	+	0	65					NR_003195.1																						GTCTGAAACTCTGAGGTCCAA	0.388000													30	48					0	0	1	0	0
MST1L	11223	broad.mit.edu	37	1	17085018	17085018	+	RNA	SNP	A	A	G			TCGA-K4-A4AB-01B-12D-A289-08	TCGA-K4-A4AB-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4b6e6192-477f-484a-bfe6-811d252fcc92	71d2241d-fa8b-4e1d-8f55-fdff8143f572	g.chr1:17085018A>G	ENST00000455405.2	-	0	170																											AGCCACGCGCAGCTTGGAACG	0.602000													16	159					0	0	1	0	0
GPR20	2843	broad.mit.edu	37	8	142367976	142367976	+	Missense_Mutation	SNP	A	A	T			TCGA-K4-A4AB-01B-12D-A289-08	TCGA-K4-A4AB-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4b6e6192-477f-484a-bfe6-811d252fcc92	71d2241d-fa8b-4e1d-8f55-fdff8143f572	g.chr8:142367976A>T	ENST00000377741.3	-	2	138	c.48T>A	c.(46-48)aaT>aaA	p.N16K		NM_005293.2	NP_005284.2	Q99678	GPR20_HUMAN	G protein-coupled receptor 20	16						integral to plasma membrane	G-protein coupled receptor activity			NS(1)|endometrium(3)|lung(4)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	15	all_cancers(97;4.32e-16)|all_epithelial(106;6.61e-14)|Lung NSC(106;9.4e-06)|all_lung(105;1.35e-05)|Ovarian(258;0.0303)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0415)			CTGCGGTGGCATTGGGGACTG	0.677000													11	27					0	0	1	0	0
FCGBP	8857	broad.mit.edu	37	19	40433886	40433886	+	Missense_Mutation	SNP	G	G	A			TCGA-K4-A4AB-01B-12D-A289-08	TCGA-K4-A4AB-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4b6e6192-477f-484a-bfe6-811d252fcc92	71d2241d-fa8b-4e1d-8f55-fdff8143f572	g.chr19:40433886G>A	ENST00000221347.6	-	2	390	c.383C>T	c.(382-384)gCg>gTg	p.A128V		NM_003890.2	NP_003881.2	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein	128	IgGFc-binding.					extracellular region	protein binding			NS(3)|autonomic_ganglia(1)|breast(7)|central_nervous_system(5)|endometrium(13)|kidney(9)|large_intestine(27)|lung(49)|ovary(8)|pancreas(3)|prostate(13)|skin(9)|stomach(9)|upper_aerodigestive_tract(6)|urinary_tract(3)	165	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			TGTCAGCTCCGCTGTGTCAGG	0.567000													11	81					0	0	1	0	0
GPATCH8	23131	broad.mit.edu	37	17	42476563	42476563	+	Missense_Mutation	SNP	C	C	G			TCGA-K4-A4AB-01B-12D-A289-08	TCGA-K4-A4AB-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4b6e6192-477f-484a-bfe6-811d252fcc92	71d2241d-fa8b-4e1d-8f55-fdff8143f572	g.chr17:42476563C>G	ENST00000434000.1	-	9	2930	c.2648G>C	c.(2647-2649)cGc>cCc	p.R883P	GPATCH8_ENST00000591680.1_Missense_Mutation_p.R961P			Q9UKJ3	GPTC8_HUMAN	G patch domain containing 8	961	Ser-rich.					intracellular	nucleic acid binding|zinc ion binding			breast(4)|endometrium(7)|kidney(6)|large_intestine(4)|liver(2)|lung(21)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	50		Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.206)		ACTGCTGCTGCGGCTGCGGCC	0.602000													32	65					0	0	1	0	0
SIGLEC5	8778	broad.mit.edu	37	19	52129343	52129343	+	Missense_Mutation	SNP	G	G	A			TCGA-K4-A4AB-01B-12D-A289-08	TCGA-K4-A4AB-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4b6e6192-477f-484a-bfe6-811d252fcc92	71d2241d-fa8b-4e1d-8f55-fdff8143f572	g.chr19:52129343G>A	ENST00000222107.4	-	8	1544	c.1406C>T	c.(1405-1407)gCa>gTa	p.A469V	SIGLEC5_ENST00000429354.3_Missense_Mutation_p.A469V|SIGLEC5_ENST00000570106.2_Missense_Mutation_p.A469V|SIGLEC5_ENST00000534261.2_Missense_Mutation_p.A469V|SIGLEC5_ENST00000599649.1_Missense_Mutation_p.A469V			O15389	SIGL5_HUMAN	sialic acid binding Ig-like lectin 5	469					cell adhesion	integral to membrane	sugar binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(3)|large_intestine(4)|lung(9)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)	27		all_neural(266;0.0726)		GBM - Glioblastoma multiforme(134;0.00124)|OV - Ovarian serous cystadenocarcinoma(262;0.0218)		TCTCCCAGCTGCTTGCTTCCT	0.542000													61	43					0	0	1	0	0
OPN1LW	5956	broad.mit.edu	37	X	153416241	153416241	+	Missense_Mutation	SNP	G	G	A			TCGA-K4-A4AB-01B-12D-A289-08	TCGA-K4-A4AB-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4b6e6192-477f-484a-bfe6-811d252fcc92	71d2241d-fa8b-4e1d-8f55-fdff8143f572	g.chrX:153416241G>A	ENST00000369951.4	+	2	286	c.226G>A	c.(226-228)Gcg>Acg	p.A76T	OPN1LW_ENST00000463296.1_3'UTR	NM_020061.4	NP_064445.2	P04000	OPSR_HUMAN	opsin 1 (cone pigments), long-wave-sensitive	76					phototransduction|protein-chromophore linkage|visual perception	integral to plasma membrane	G-protein coupled receptor activity|photoreceptor activity			endometrium(3)|large_intestine(2)|lung(8)|ovary(1)|skin(1)	15	all_cancers(53;1.83e-16)|all_epithelial(53;2.73e-10)|all_lung(58;6.39e-07)|Lung NSC(58;8.37e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					GCTTGTGCTGGCGGCCACCAT	0.567000													33	98					0	0	1	0	0
HIST1H4I	8294	broad.mit.edu	37	6	27107308	27107308	+	Missense_Mutation	SNP	C	C	A			TCGA-K4-A4AB-01B-12D-A289-08	TCGA-K4-A4AB-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4b6e6192-477f-484a-bfe6-811d252fcc92	71d2241d-fa8b-4e1d-8f55-fdff8143f572	g.chr6:27107308C>A	ENST00000354348.2	+	1	233	c.221C>A	c.(220-222)aCg>aAg	p.T74K	HIST1H2BK_ENST00000396891.4_Intron	NM_003495.2	NP_003486.1	P62805	H4_HUMAN	histone cluster 1, H4i	74					CenH3-containing nucleosome assembly at centromere|negative regulation of megakaryocyte differentiation|phosphatidylinositol-mediated signaling|telomere maintenance	nucleoplasm|nucleosome	DNA binding|protein binding			lung(1)	1						GTGACCTACACGGAGCACGCC	0.627000			T	BCL6	NHL								27	66					2.41591e-17	2.68838e-17	1	1	0
ATG14	22863	broad.mit.edu	37	14	55878361	55878361	+	Missense_Mutation	SNP	C	C	G			TCGA-K4-A4AB-01B-12D-A289-08	TCGA-K4-A4AB-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4b6e6192-477f-484a-bfe6-811d252fcc92	71d2241d-fa8b-4e1d-8f55-fdff8143f572	g.chr14:55878361C>G	ENST00000247178.5	-	1	215	c.180G>C	c.(178-180)caG>caC	p.Q60H		NM_014924.4	NP_055739.2	Q6ZNE5	BAKOR_HUMAN	autophagy related 14	60					autophagic vacuole assembly|positive regulation of autophagy	autophagic vacuole|endoplasmic reticulum|pre-autophagosomal structure membrane	protein binding			central_nervous_system(1)|endometrium(2)|large_intestine(2)|lung(6)|prostate(2)	13						AATCGCCGCTCTGAACGCATT	0.662000													9	20					0	0	1	0	0
GRIA2	2891	broad.mit.edu	37	4	158238833	158238833	+	Silent	SNP	T	T	G			TCGA-K4-A4AB-01B-12D-A289-08	TCGA-K4-A4AB-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4b6e6192-477f-484a-bfe6-811d252fcc92	71d2241d-fa8b-4e1d-8f55-fdff8143f572	g.chr4:158238833T>G	ENST00000296526.7	+	5	1015	c.690T>G	c.(688-690)gtT>gtG	p.V230V	GRIA2_ENST00000264426.9_Silent_p.V230V|GRIA2_ENST00000449365.1_Silent_p.V183V|GRIA2_ENST00000507898.1_Silent_p.V183V|GRIA2_ENST00000393815.2_Silent_p.V183V	NM_000826.3	NP_000817	P42262	GRIA2_HUMAN	glutamate receptor, ionotropic, AMPA 2	230					synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|endocytic vesicle membrane|endoplasmic reticulum membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			NS(1)|breast(2)|central_nervous_system(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(16)|liver(2)|lung(32)|ovary(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	79	all_hematologic(180;0.24)	Renal(120;0.0458)		COAD - Colon adenocarcinoma(41;0.0294)	L-Glutamic Acid(DB00142)	GAAAACATGTTAAAGGGTACC	0.234000													10	9					0	0	1	0	0
TAF11	6882	broad.mit.edu	37	6	34855587	34855587	+	Missense_Mutation	SNP	C	C	T			TCGA-K4-A4AB-01B-12D-A289-08	TCGA-K4-A4AB-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4b6e6192-477f-484a-bfe6-811d252fcc92	71d2241d-fa8b-4e1d-8f55-fdff8143f572	g.chr6:34855587C>T	ENST00000361288.4	-	1	279	c.148G>A	c.(148-150)Gaa>Aaa	p.E50K	TAF11_ENST00000420584.2_Missense_Mutation_p.E50K	NM_005643.3	NP_005634.1	Q15544	TAF11_HUMAN	TAF11 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 28kDa	50					positive regulation by host of viral transcription|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|viral reproduction	transcription factor TFIID complex	protein N-terminus binding|thyroid hormone receptor binding|transcription coactivator activity|vitamin D receptor binding			endometrium(2)|kidney(1)|large_intestine(2)|lung(1)	6						GCTGCAGCTTCTTTCAAGTCC	0.587000													100	112					0	0	1	0	0
NCR2	9436	broad.mit.edu	37	6	41309536	41309536	+	Silent	SNP	T	T	G			TCGA-K4-A4AB-01B-12D-A289-08	TCGA-K4-A4AB-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4b6e6192-477f-484a-bfe6-811d252fcc92	71d2241d-fa8b-4e1d-8f55-fdff8143f572	g.chr6:41309536T>G	ENST00000373083.4	+	3	621	c.399T>G	c.(397-399)tcT>tcG	p.S133S	NCR2_ENST00000373089.5_Silent_p.S133S|NCR2_ENST00000373086.3_Silent_p.S133S	NM_001199510.1	NP_001186439.1	O95944	NCTR2_HUMAN	natural cytotoxicity triggering receptor 2	133					cellular defense response	integral to plasma membrane	transmembrane receptor activity			NS(1)|breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(3)|ovary(1)|urinary_tract(1)	14	Ovarian(28;0.0327)|Colorectal(47;0.196)					TGGCAGCCTCTGCCTCCACAC	0.632000													59	68					0	0	1	0	0
TGFBR1	7046	broad.mit.edu	37	9	101904817	101904817	+	Splice_Site	SNP	G	G	A			TCGA-K4-A4AB-01B-12D-A289-08	TCGA-K4-A4AB-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4b6e6192-477f-484a-bfe6-811d252fcc92	71d2241d-fa8b-4e1d-8f55-fdff8143f572	g.chr9:101904817G>A	ENST00000374994.4	+	5	922		c.e5-1		TGFBR1_ENST00000552516.1_Splice_Site|TGFBR1_ENST00000550253.1_Splice_Site|TGFBR1_ENST00000374990.2_Splice_Site	NM_004612.2	NP_004603.1	P36897	TGFR1_HUMAN	transforming growth factor, beta receptor 1						activation of MAPKK activity|anterior/posterior pattern formation|artery morphogenesis|collagen fibril organization|embryonic cranial skeleton morphogenesis|germ cell migration|heart development|kidney development|neuron fate commitment|palate development|parathyroid gland development|pathway-restricted SMAD protein phosphorylation|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|pharyngeal system development|positive regulation of cell growth|positive regulation of cell proliferation|positive regulation of cellular component movement|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of protein kinase B signaling cascade|positive regulation of SMAD protein import into nucleus|positive regulation of survival gene product expression|positive regulation of transcription, DNA-dependent|response to cholesterol|thymus development|transforming growth factor beta receptor signaling pathway		ATP binding|I-SMAD binding|metal ion binding|transforming growth factor beta binding|transforming growth factor beta receptor activity, type I|type II transforming growth factor beta receptor binding			endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(10)|liver(1)|lung(7)|ovary(1)|prostate(1)|skin(1)	27		Acute lymphoblastic leukemia(62;0.0559)				CTGTTTTACAGACAATGGTAC	0.378000													29	14					0	0	1	0	0
NXPH1	30010	broad.mit.edu	37	7	8790921	8790921	+	Missense_Mutation	SNP	G	G	A			TCGA-K4-A4AB-01B-12D-A289-08	TCGA-K4-A4AB-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4b6e6192-477f-484a-bfe6-811d252fcc92	71d2241d-fa8b-4e1d-8f55-fdff8143f572	g.chr7:8790921G>A	ENST00000405863.1	+	3	1249	c.338G>A	c.(337-339)gGc>gAc	p.G113D	NXPH1_ENST00000497400.1_3'UTR|NXPH1_ENST00000602349.1_5'UTR	NM_152745.2	NP_689958.1	P58417	NXPH1_HUMAN	neurexophilin 1	113	III.					extracellular region				breast(2)|central_nervous_system(1)|endometrium(2)|large_intestine(4)|lung(7)|ovary(1)	17		Ovarian(82;0.0628)		UCEC - Uterine corpus endometrioid carcinoma (126;0.101)		GTTAAAACGGGCAAGTTTAAG	0.463000													28	60					0	0	1	0	0
CXorf21	80231	broad.mit.edu	37	X	30578311	30578311	+	Silent	SNP	G	G	C			TCGA-K4-A4AB-01B-12D-A289-08	TCGA-K4-A4AB-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4b6e6192-477f-484a-bfe6-811d252fcc92	71d2241d-fa8b-4e1d-8f55-fdff8143f572	g.chrX:30578311G>C	ENST00000378962.3	-	3	484	c.162C>G	c.(160-162)ctC>ctG	p.L54L		NM_025159.2	NP_079435.1	Q9HAI6	CX021_HUMAN	chromosome X open reading frame 21	54										kidney(1)|large_intestine(3)|lung(13)|ovary(1)|stomach(1)|urinary_tract(1)	20						AGCTCACGTAGAGACTTCTGA	0.458000													76	39					0	0	1	0	0
NF1	4763	broad.mit.edu	37	17	29665073	29665073	+	Silent	SNP	A	A	G			TCGA-K4-A4AB-01B-12D-A289-08	TCGA-K4-A4AB-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4b6e6192-477f-484a-bfe6-811d252fcc92	71d2241d-fa8b-4e1d-8f55-fdff8143f572	g.chr17:29665073A>G	ENST00000358273.4	+	45	7118	c.6735A>G	c.(6733-6735)caA>caG	p.Q2245Q	NF1_ENST00000444181.2_Silent_p.Q38Q|NF1_ENST00000417592.2_Intron|NF1_ENST00000356175.3_Silent_p.Q2224Q	NM_001042492.2	NP_001035957.1	P21359	NF1_HUMAN	neurofibromin 1	2245					actin cytoskeleton organization|adrenal gland development|artery morphogenesis|camera-type eye morphogenesis|cerebral cortex development|collagen fibril organization|forebrain astrocyte development|forebrain morphogenesis|heart development|liver development|MAPKKK cascade|metanephros development|myelination in peripheral nervous system|negative regulation of cell migration|negative regulation of endothelial cell proliferation|negative regulation of MAP kinase activity|negative regulation of MAPKKK cascade|negative regulation of neuroblast proliferation|negative regulation of oligodendrocyte differentiation|negative regulation of transcription factor import into nucleus|osteoblast differentiation|phosphatidylinositol 3-kinase cascade|pigmentation|positive regulation of adenylate cyclase activity|positive regulation of neuron apoptosis|Ras protein signal transduction|regulation of blood vessel endothelial cell migration|regulation of bone resorption|response to hypoxia|smooth muscle tissue development|spinal cord development|sympathetic nervous system development|visual learning|wound healing	axon|cytoplasm|dendrite|intrinsic to internal side of plasma membrane|nucleus	protein binding|Ras GTPase activator activity	p.0?(8)|p.?(3)	NF1/ACCN1(2)	autonomic_ganglia(12)|breast(11)|central_nervous_system(72)|cervix(6)|endometrium(12)|haematopoietic_and_lymphoid_tissue(59)|kidney(9)|large_intestine(39)|liver(1)|lung(80)|ovary(20)|pancreas(2)|prostate(2)|skin(8)|soft_tissue(249)|stomach(2)|thyroid(1)|upper_aerodigestive_tract(5)|urinary_tract(9)	599		all_cancers(10;1.29e-12)|all_epithelial(10;0.00347)|all_hematologic(16;0.00556)|Acute lymphoblastic leukemia(14;0.00593)|Breast(31;0.014)|Myeloproliferative disorder(56;0.0255)|all_lung(9;0.0321)|Lung NSC(157;0.0659)		UCEC - Uterine corpus endometrioid carcinoma (4;4.38e-05)|all cancers(4;1.64e-26)|Epithelial(4;9.15e-23)|OV - Ovarian serous cystadenocarcinoma(4;3.58e-21)|GBM - Glioblastoma multiforme(4;0.00146)		CATCCCTGCAACCAAGAGCTC	0.358000			"""D, Mis, N, F, S, O"""		"""neurofibroma, glioma"""	"""neurofibroma, glioma"""			Neurofibromatosis, type 1	TCGA GBM(6;<1E-08)|TSP Lung(7;0.0071)|TCGA Ovarian(3;0.0088)			59	79					0	0	1	0	0
YY1	7528	broad.mit.edu	37	14	100728716	100728716	+	Missense_Mutation	SNP	C	C	T			TCGA-K4-A4AB-01B-12D-A289-08	TCGA-K4-A4AB-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4b6e6192-477f-484a-bfe6-811d252fcc92	71d2241d-fa8b-4e1d-8f55-fdff8143f572	g.chr14:100728716C>T	ENST00000262238.4	+	2	1015	c.755C>T	c.(754-756)tCa>tTa	p.S252L		NM_003403.3	NP_003394.1	P25490	TYY1_HUMAN	YY1 transcription factor	252					cell differentiation|cellular response to UV|double-strand break repair via homologous recombination|negative regulation of transcription from RNA polymerase II promoter|response to UV-C|spermatogenesis	Ino80 complex|nuclear matrix|plasma membrane	four-way junction DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity|transcription regulatory region DNA binding|zinc ion binding			cervix(1)|endometrium(1)|large_intestine(1)|liver(2)|lung(1)|prostate(4)|skin(1)	11		Melanoma(154;0.152)				CCTGATTATTCAGAATATATG	0.383000													20	54					0	0	1	0	0
OR51G2	81282	broad.mit.edu	37	11	4936310	4936310	+	Missense_Mutation	SNP	G	G	A			TCGA-K4-A4AB-01B-12D-A289-08	TCGA-K4-A4AB-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4b6e6192-477f-484a-bfe6-811d252fcc92	71d2241d-fa8b-4e1d-8f55-fdff8143f572	g.chr11:4936310G>A	ENST00000322013.3	-	1	612	c.584C>T	c.(583-585)gCc>gTc	p.A195V	MMP26_ENST00000380390.1_Intron|MMP26_ENST00000477339.1_Intron	NM_001005238.1	NP_001005238.1	Q8NGK0	O51G2_HUMAN	olfactory receptor, family 51, subfamily G, member 2	195					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			autonomic_ganglia(1)|endometrium(1)|large_intestine(9)|lung(12)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;5.06e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00438)|LUSC - Lung squamous cell carcinoma(625;0.19)		CTTCATGTCGGCACAGGCCAA	0.463000													4	64					0	0	1	0	0
KAT2B	8850	broad.mit.edu	37	3	20161115	20161115	+	Silent	SNP	G	G	C			TCGA-K4-A4AB-01B-12D-A289-08	TCGA-K4-A4AB-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4b6e6192-477f-484a-bfe6-811d252fcc92	71d2241d-fa8b-4e1d-8f55-fdff8143f572	g.chr3:20161115G>C	ENST00000263754.4	+	8	1631	c.1176G>C	c.(1174-1176)ggG>ggC	p.G392G		NM_003884.4	NP_003875.3	Q92831	KAT2B_HUMAN	K(lysine) acetyltransferase 2B	392					cell cycle arrest|cellular response to insulin stimulus|chromatin remodeling|histone H3 acetylation|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|negative regulation of cell proliferation|transcription initiation from RNA polymerase I promoter	Ada2/Gcn5/Ada3 transcription activator complex|chromatin remodeling complex|PCAF complex	cyclin-dependent protein kinase inhibitor activity|histone acetyltransferase activity|histone deacetylase binding|protein kinase binding|transcription coactivator activity|transcription factor binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|lung(15)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(1)	40						CTGTGGCTGGGACAATTTCAT	0.498000													15	48					0	0	1	0	0
UTRN	7402	broad.mit.edu	37	6	144784000	144784000	+	Nonsense_Mutation	SNP	G	G	T			TCGA-K4-A4AB-01B-12D-A289-08	TCGA-K4-A4AB-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4b6e6192-477f-484a-bfe6-811d252fcc92	71d2241d-fa8b-4e1d-8f55-fdff8143f572	g.chr6:144784000G>T	ENST00000367545.3	+	22	3064	c.3064G>T	c.(3064-3066)Gag>Tag	p.E1022*		NM_007124.2	NP_009055.2	P46939	UTRO_HUMAN	utrophin	1022					muscle contraction|muscle organ development|positive regulation of cell-matrix adhesion	cell junction|cytoplasm|cytoskeleton|membrane fraction|nucleus|postsynaptic membrane	actin binding|calcium ion binding|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(7)|central_nervous_system(1)|cervix(2)|endometrium(21)|kidney(10)|large_intestine(29)|lung(56)|ovary(5)|pancreas(1)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	148		Ovarian(120;0.218)		OV - Ovarian serous cystadenocarcinoma(155;5.72e-07)|GBM - Glioblastoma multiforme(68;4.9e-05)|Colorectal(48;0.213)		CAGAGCTTTTGAGGTAAATCC	0.338000													16	57					3.52763e-06	3.67669e-06	1	1	0
MYH7	4625	broad.mit.edu	37	14	23887583	23887583	+	Silent	SNP	C	C	T	rs144465613	byFrequency	TCGA-K4-A4AB-01B-12D-A289-08	TCGA-K4-A4AB-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4b6e6192-477f-484a-bfe6-811d252fcc92	71d2241d-fa8b-4e1d-8f55-fdff8143f572	g.chr14:23887583C>T	ENST00000355349.3	-	30	4167	c.4005G>A	c.(4003-4005)tcG>tcA	p.S1335S		NM_000257.2	NP_000248.2	P12883	MYH7_HUMAN	myosin, heavy chain 7, cardiac muscle, beta	1335					adult heart development|muscle filament sliding|regulation of heart rate|ventricular cardiac muscle tissue morphogenesis	focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle	p.S1335S(3)		NS(3)|breast(4)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(19)|lung(57)|ovary(5)|prostate(9)|skin(5)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	137	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00725)		CATGCCGGGCCGACTGCAGTG	0.662000													8	64					0	0	1	0	0
ZNF839	55778	broad.mit.edu	37	14	102807669	102807669	+	Missense_Mutation	SNP	C	C	G			TCGA-K4-A4AB-01B-12D-A289-08	TCGA-K4-A4AB-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4b6e6192-477f-484a-bfe6-811d252fcc92	71d2241d-fa8b-4e1d-8f55-fdff8143f572	g.chr14:102807669C>G	ENST00000262236.5	+	8	1950	c.1595C>G	c.(1594-1596)cCt>cGt	p.P532R	ZNF839_ENST00000558850.1_Missense_Mutation_p.P530R|ZNF839_ENST00000420933.2_3'UTR|ZNF839_ENST00000442396.2_Missense_Mutation_p.P646R|ZNF839_ENST00000559185.1_Missense_Mutation_p.P530R	NM_018335.4	NP_060805.3	A8K0R7	ZN839_HUMAN	zinc finger protein 839	530						intracellular	zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(5)|large_intestine(2)|lung(5)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	19						GGTTTTTCCCCTCCAGTAAAT	0.532000													22	49					0	0	1	0	0
CCDC178	374864	broad.mit.edu	37	18	30846940	30846940	+	Missense_Mutation	SNP	G	G	A			TCGA-K4-A4AB-01B-12D-A289-08	TCGA-K4-A4AB-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4b6e6192-477f-484a-bfe6-811d252fcc92	71d2241d-fa8b-4e1d-8f55-fdff8143f572	g.chr18:30846940G>A	ENST00000383096.3	-	14	1531	c.1349C>T	c.(1348-1350)aCg>aTg	p.T450M	CCDC178_ENST00000403303.1_Missense_Mutation_p.T450M|CCDC178_ENST00000406524.2_Missense_Mutation_p.T450M|CCDC178_ENST00000402325.1_Missense_Mutation_p.T450M|CCDC178_ENST00000579947.1_Missense_Mutation_p.T450M|CCDC178_ENST00000579916.1_Intron|CCDC178_ENST00000300227.8_Missense_Mutation_p.T450M|CCDC178_ENST00000583930.1_Missense_Mutation_p.T450M					coiled-coil domain containing 178																		ATTGTCTTCCGTCAGTTTTGT	0.274000													8	12					0	0	1	0	0
CTNNAL1	8727	broad.mit.edu	37	9	111741706	111741706	+	Missense_Mutation	SNP	G	G	A			TCGA-K4-A4AB-01B-12D-A289-08	TCGA-K4-A4AB-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4b6e6192-477f-484a-bfe6-811d252fcc92	71d2241d-fa8b-4e1d-8f55-fdff8143f572	g.chr9:111741706G>A	ENST00000374595.4	-	7	1035	c.956C>T	c.(955-957)tCt>tTt	p.S319F	CTNNAL1_ENST00000325580.6_Missense_Mutation_p.S319F|CTNNAL1_ENST00000325551.4_Missense_Mutation_p.S319F			Q9UBT7	CTNL1_HUMAN	catenin (cadherin-associated protein), alpha-like 1	319					cell adhesion|Rho protein signal transduction	actin cytoskeleton|cytosol|plasma membrane	cadherin binding|structural molecule activity			cervix(1)|endometrium(2)|kidney(1)|large_intestine(9)|lung(5)|ovary(1)|prostate(4)|urinary_tract(2)	25				STAD - Stomach adenocarcinoma(157;0.0768)		CAATGTCACAGAAAGGTTCTC	0.423000													28	16					0	0	1	0	0
TCFL5	10732	broad.mit.edu	37	20	61485398	61485398	+	Missense_Mutation	SNP	G	G	C			TCGA-K4-A4AB-01B-12D-A289-08	TCGA-K4-A4AB-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4b6e6192-477f-484a-bfe6-811d252fcc92	71d2241d-fa8b-4e1d-8f55-fdff8143f572	g.chr20:61485398G>C	ENST00000335351.3	-	5	1442	c.1350C>G	c.(1348-1350)atC>atG	p.I450M	TCFL5_ENST00000217162.5_Missense_Mutation_p.I402M	NM_006602.2	NP_006593.2	Q9UL49	TCFL5_HUMAN	transcription factor-like 5 (basic helix-loop-helix)	450	Helix-loop-helix motif.				cell differentiation|multicellular organismal development|regulation of cell differentiation|regulation of cell proliferation|spermatogenesis|transcription from RNA polymerase II promoter		DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(1)|large_intestine(5)|lung(1)|urinary_tract(1)	9	Breast(26;5.68e-08)					GTCTTTCCTGGATGTATTTCA	0.418000													32	50					0	0	1	0	0
SPNS1	83985	broad.mit.edu	37	16	28990582	28990582	+	Missense_Mutation	SNP	G	G	A			TCGA-K4-A4AB-01B-12D-A289-08	TCGA-K4-A4AB-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4b6e6192-477f-484a-bfe6-811d252fcc92	71d2241d-fa8b-4e1d-8f55-fdff8143f572	g.chr16:28990582G>A	ENST00000311008.11	+	4	928	c.551G>A	c.(550-552)cGg>cAg	p.R184Q	SPNS1_ENST00000323081.8_Missense_Mutation_p.R111Q|SPNS1_ENST00000561868.1_3'UTR|RP11-264B17.3_ENST00000569969.1_RNA|SPNS1_ENST00000565975.1_Missense_Mutation_p.R229Q|SPNS1_ENST00000352260.7_Missense_Mutation_p.R162Q|SPNS1_ENST00000334536.8_Missense_Mutation_p.R184Q	NM_032038.2	NP_114427.1	Q9H2V7	SPNS1_HUMAN	spinster homolog 1 (Drosophila)	184					lipid transport|transmembrane transport	integral to membrane|mitochondrial inner membrane	protein binding			cervix(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(9)|prostate(1)|skin(2)|urinary_tract(1)	21						GCCGACCAGCGGAGCCGGATG	0.662000													53	145					0	0	1	0	0
SYNE3	161176	broad.mit.edu	37	14	95905371	95905371	+	Splice_Site	SNP	C	C	T			TCGA-K4-A4AB-01B-12D-A289-08	TCGA-K4-A4AB-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4b6e6192-477f-484a-bfe6-811d252fcc92	71d2241d-fa8b-4e1d-8f55-fdff8143f572	g.chr14:95905371C>T	ENST00000334258.5	-	13	2389	c.2375G>A	c.(2374-2376)cGc>cAc	p.R792H	SYNE3_ENST00000554873.1_Splice_Site_p.R549H|SYNE3_ENST00000557275.1_Splice_Site_p.R792H	NM_152592.3	NP_689805.3			spectrin repeat containing, nuclear envelope family member 3											breast(1)|endometrium(2)|lung(25)	28						CAGACTCACGCGTCGACGATG	0.562000													71	141					0	0	1	0	0
SLC7A8	23428	broad.mit.edu	37	14	23597256	23597256	+	Silent	SNP	G	G	A			TCGA-K4-A4AB-01B-12D-A289-08	TCGA-K4-A4AB-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4b6e6192-477f-484a-bfe6-811d252fcc92	71d2241d-fa8b-4e1d-8f55-fdff8143f572	g.chr14:23597256G>A	ENST00000316902.7	-	10	2138	c.1413C>T	c.(1411-1413)caC>caT	p.H471H	SLC7A8_ENST00000453702.1_Silent_p.H268H|SLC7A8_ENST00000422941.2_Silent_p.H247H|SLC7A8_ENST00000529705.2_Silent_p.H366H|SLC7A8_ENST00000469263.1_Intron	NM_012244.3	NP_036376.2	Q9UHI5	LAT2_HUMAN	solute carrier family 7 (amino acid transporter light chain, L system), member 8	471					blood coagulation|cellular amino acid metabolic process|leukocyte migration|metal ion homeostasis|response to toxin	basolateral plasma membrane|cytoplasm|integral to plasma membrane	neutral amino acid transmembrane transporter activity|organic cation transmembrane transporter activity|peptide antigen binding|protein binding|toxin transporter activity			autonomic_ganglia(1)|endometrium(6)|kidney(4)|large_intestine(6)|lung(5)|ovary(1)|skin(1)	24	all_cancers(95;4.6e-05)			GBM - Glioblastoma multiforme(265;0.00809)	L-Alanine(DB00160)|L-Glutamine(DB00130)|L-Phenylalanine(DB00120)	ACTTGGGCTTGTGTTGCCAGT	0.562000													26	45					0	0	1	0	0
MDC1	9656	broad.mit.edu	37	6	30673873	30673873	+	Silent	SNP	G	G	A	rs149848514	by1000genomes	TCGA-K4-A4AB-01B-12D-A289-08	TCGA-K4-A4AB-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4b6e6192-477f-484a-bfe6-811d252fcc92	71d2241d-fa8b-4e1d-8f55-fdff8143f572	g.chr6:30673873G>A	ENST00000376406.3	-	10	3734	c.3087C>T	c.(3085-3087)ggC>ggT	p.G1029G	MDC1_ENST00000376405.2_Silent_p.G765G|MDC1-AS1_ENST00000442150.1_RNA	NM_014641.2	NP_055456.2	Q14676	MDC1_HUMAN	mediator of DNA-damage checkpoint 1	1029				Missing (in Ref. 2; CAH18685).	cell cycle|double-strand break repair via homologous recombination|intra-S DNA damage checkpoint	focal adhesion|nucleoplasm	FHA domain binding|protein C-terminus binding			breast(2)|kidney(1)|ovary(1)	4						ATTCCTGATCGCCCTAGGGAG	0.493000								Other conserved DNA damage response genes					36	40					0	0	1	0	0
FGF23	8074	broad.mit.edu	37	12	4479679	4479679	+	Missense_Mutation	SNP	G	G	C			TCGA-K4-A4AB-01B-12D-A289-08	TCGA-K4-A4AB-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4b6e6192-477f-484a-bfe6-811d252fcc92	71d2241d-fa8b-4e1d-8f55-fdff8143f572	g.chr12:4479679G>C	ENST00000237837.1	-	3	731	c.586C>G	c.(586-588)Cgg>Ggg	p.R196G		NM_020638.2	NP_065689.1	Q9GZV9	FGF23_HUMAN	fibroblast growth factor 23	196					cell differentiation|insulin receptor signaling pathway|negative regulation of bone mineralization|negative regulation of hormone secretion|negative regulation of osteoblast differentiation|positive regulation of vitamin D 24-hydroxylase activity|regulation of phosphate transport|vitamin D catabolic process	extracellular space	growth factor activity			NS(1)|breast(2)|kidney(1)|large_intestine(1)|lung(7)|ovary(2)|pancreas(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)	22			Colorectal(7;0.00165)|COAD - Colon adenocarcinoma(12;0.0229)|STAD - Stomach adenocarcinoma(119;0.206)			ATCCGGGCCCGGGGCTTCAGC	0.687000													32	47					0	0	1	0	0
ATP1A3	478	broad.mit.edu	37	19	42485710	42485710	+	Missense_Mutation	SNP	G	G	A			TCGA-K4-A4AB-01B-12D-A289-08	TCGA-K4-A4AB-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4b6e6192-477f-484a-bfe6-811d252fcc92	71d2241d-fa8b-4e1d-8f55-fdff8143f572	g.chr19:42485710G>A	ENST00000545399.1	-	11	1573	c.1420C>T	c.(1420-1422)Cgt>Tgt	p.R474C	ATP1A3_ENST00000543770.1_Missense_Mutation_p.R472C|ATP1A3_ENST00000602133.1_Missense_Mutation_p.R431C|ATP1A3_ENST00000302102.5_Missense_Mutation_p.R461C	NM_001256214.1	NP_001243143.1	P13637	AT1A3_HUMAN	ATPase, Na+/K+ transporting, alpha 3 polypeptide	461					ATP biosynthetic process	endoplasmic reticulum|Golgi apparatus	ATP binding|metal ion binding|sodium:potassium-exchanging ATPase activity			NS(1)|breast(2)|endometrium(7)|kidney(2)|large_intestine(11)|liver(1)|lung(19)|ovary(1)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)	52						TTGCGTTCACGCATCAGCTTC	0.557000													13	107					0	0	1	0	0
PIK3CA	5290	broad.mit.edu	37	3	178952085	178952085	+	Missense_Mutation	SNP	A	A	G	rs121913279		TCGA-K4-A4AB-01B-12D-A289-08	TCGA-K4-A4AB-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4b6e6192-477f-484a-bfe6-811d252fcc92	71d2241d-fa8b-4e1d-8f55-fdff8143f572	g.chr3:178952085A>G	ENST00000263967.3	+	21	3297	c.3140A>G	c.(3139-3141)cAt>cGt	p.H1047R		NM_006218.2	NP_006209.2	P42336	PK3CA_HUMAN	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha	1047	PI3K/PI4K.		H -> L (in cancer).|H -> R (in KERSEB; shows an increase in lipid kinase activity; oncogenic in vivo; requires binding to p85 regulatory subunit to induce cellular transformation but not interaction with RAS; may mimic the conformatitonal change triggered by the interaction with RAS; enhances invadopodia-mediated extracellular matrix degradation and invasion in breast cancer cells; increases lipid kinase activity; may alter the interaction of the PI3K/ PI4K kinase domain with the cell membrane).|H -> Y (in cancer).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.H1047R(1387)|p.H1047L(194)|p.H1047P(1)		NS(16)|autonomic_ganglia(4)|biliary_tract(22)|bone(1)|breast(2150)|central_nervous_system(110)|cervix(33)|endometrium(473)|eye(1)|haematopoietic_and_lymphoid_tissue(35)|kidney(14)|large_intestine(1202)|liver(42)|lung(202)|meninges(1)|oesophagus(28)|ovary(235)|pancreas(17)|penis(8)|pituitary(12)|prostate(10)|skin(155)|small_intestine(1)|soft_tissue(18)|stomach(121)|thyroid(80)|upper_aerodigestive_tract(70)|urinary_tract(208)	5269	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			AATGATGCACATCATGGTGGC	0.378000	H1047L(EFM19_BREAST)|H1047R(BT20_BREAST)|H1047R(CAL29_URINARY_TRACT)|H1047R(CAL33_UPPER_AERODIGESTIVE_TRACT)|H1047R(DETROIT562_UPPER_AERODIGESTIVE_TRACT)|H1047R(HCC1954_BREAST)|H1047R(HCT116_LARGE_INTESTINE)|H1047R(HSC2_UPPER_AERODIGESTIVE_TRACT)|H1047R(LS180_LARGE_INTESTINE)|H1047R(MCAS_OVARY)|H1047R(MDAMB453_BREAST)|H1047R(NCIH1048_LUNG)|H1047R(RKO_LARGE_INTESTINE)|H1047R(SKOV3_OVARY)|H1047R(T47D_BREAST)	57	Mis		"""colorectal, gastric, gliobastoma, breast"""					HNSCC(19;0.045)|TSP Lung(28;0.18)			23	48					0	0	1	0	0
VNN1	8876	broad.mit.edu	37	6	133004406	133004406	+	Missense_Mutation	SNP	G	G	A			TCGA-K4-A4AB-01B-12D-A289-08	TCGA-K4-A4AB-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4b6e6192-477f-484a-bfe6-811d252fcc92	71d2241d-fa8b-4e1d-8f55-fdff8143f572	g.chr6:133004406G>A	ENST00000367928.4	-	7	1428	c.1415C>T	c.(1414-1416)aCa>aTa	p.T472I		NM_004666.2	NP_004657.2	O95497	VNN1_HUMAN	vanin 1	472					acute inflammatory response|anti-apoptosis|cell-cell adhesion|cellular component movement|chronic inflammatory response|innate immune response|pantothenate metabolic process|positive regulation of T cell differentiation in thymus|response to oxidative stress	anchored to membrane|integral to membrane|plasma membrane	GPI anchor binding|pantetheine hydrolase activity			NS(2)|endometrium(3)|kidney(2)|large_intestine(8)|lung(10)|ovary(4)|prostate(1)|upper_aerodigestive_tract(1)	31	Breast(56;0.135)			OV - Ovarian serous cystadenocarcinoma(155;0.0027)|GBM - Glioblastoma multiforme(226;0.0189)		CAGAGTTACTGTTAAGACAGG	0.418000													24	21					0	0	1	0	0
SEMA3A	10371	broad.mit.edu	37	7	83758452	83758452	+	Missense_Mutation	SNP	C	C	T			TCGA-K4-A4AB-01B-12D-A289-08	TCGA-K4-A4AB-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4b6e6192-477f-484a-bfe6-811d252fcc92	71d2241d-fa8b-4e1d-8f55-fdff8143f572	g.chr7:83758452C>T	ENST00000265362.4	-	3	634	c.320G>A	c.(319-321)gGa>gAa	p.G107E	SEMA3A_ENST00000436949.1_Missense_Mutation_p.G107E	NM_006080.2	NP_006071.1	Q14563	SEM3A_HUMAN	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A		Sema.				axon guidance	extracellular region|membrane	receptor activity			breast(3)|cervix(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|liver(1)|lung(22)|ovary(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	53						GATGTCTTTTCCAGCCCACTT	0.353000													17	44					0	0	1	0	0
KMT2A	4297	broad.mit.edu	37	11	118344057	118344057	+	Missense_Mutation	SNP	C	C	T			TCGA-K4-A4AB-01B-12D-A289-08	TCGA-K4-A4AB-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4b6e6192-477f-484a-bfe6-811d252fcc92	71d2241d-fa8b-4e1d-8f55-fdff8143f572	g.chr11:118344057C>T	ENST00000534358.1	+	3	2206	c.2183C>T	c.(2182-2184)tCt>tTt	p.S728F	KMT2A_ENST00000354520.4_Missense_Mutation_p.S728F|KMT2A_ENST00000389506.5_Missense_Mutation_p.S728F	NM_001197104.1|NM_005933.3	NP_001184033.1|NP_005924.2			lysine (K)-specific methyltransferase 2A																		GGAACATCTTCTTCAGGAGTA	0.418000													24	12					0	0	1	0	0
METTL12	751071	broad.mit.edu	37	11	62433367	62433367	+	Nonsense_Mutation	SNP	C	C	T			TCGA-K4-A4AB-01B-12D-A289-08	TCGA-K4-A4AB-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4b6e6192-477f-484a-bfe6-811d252fcc92	71d2241d-fa8b-4e1d-8f55-fdff8143f572	g.chr11:62433367C>T	ENST00000532971.1	+	2	273	c.16C>T	c.(16-18)Cga>Tga	p.R6*	C11orf48_ENST00000532208.1_Intron|METTL12_ENST00000398922.2_3'UTR|C11orf48_ENST00000431002.2_Intron|C11orf48_ENST00000354588.3_Intron	NM_001043229.1	NP_001036694.1	A8MUP2	MTL12_HUMAN	methyltransferase like 12	6						mitochondrion	methyltransferase activity			endometrium(1)|large_intestine(1)|lung(2)|ovary(1)|urinary_tract(1)	6						CGCGCTGCGTCGAATGCTCCA	0.637000													27	49					0	0	1	0	0
OLFML1	283298	broad.mit.edu	37	11	7531133	7531133	+	Nonsense_Mutation	SNP	G	G	A			TCGA-K4-A4AB-01B-12D-A289-08	TCGA-K4-A4AB-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4b6e6192-477f-484a-bfe6-811d252fcc92	71d2241d-fa8b-4e1d-8f55-fdff8143f572	g.chr11:7531133G>A	ENST00000329293.3	+	3	1317	c.923G>A	c.(922-924)tGg>tAg	p.W308*	OLFML1_ENST00000528758.1_3'UTR|CTD-2516F10.2_ENST00000530201.1_RNA|OLFML1_ENST00000530135.1_Nonsense_Mutation_p.W308*	NM_198474.3	NP_940876.2	Q6UWY5	OLFL1_HUMAN	olfactomedin-like 1	308	Olfactomedin-like.					extracellular region				breast(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(8)|ovary(3)|prostate(2)	24				Epithelial(150;6.96e-08)|BRCA - Breast invasive adenocarcinoma(625;0.194)		GAGCATTCATGGGATACCCCA	0.572000													25	53					0	0	1	0	0
TARBP1	6894	broad.mit.edu	37	1	234536968	234536968	+	Missense_Mutation	SNP	A	A	G			TCGA-K4-A4AB-01B-12D-A289-08	TCGA-K4-A4AB-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4b6e6192-477f-484a-bfe6-811d252fcc92	71d2241d-fa8b-4e1d-8f55-fdff8143f572	g.chr1:234536968A>G	ENST00000040877.1	-	25	4029	c.4030T>C	c.(4030-4032)Ttt>Ctt	p.F1344L	TARBP1_ENST00000483404.1_5'UTR	NM_005646.3	NP_005637.3	Q13395	TARB1_HUMAN	TAR (HIV-1) RNA binding protein 1	1344					regulation of transcription from RNA polymerase II promoter|RNA processing	nucleus	RNA binding|RNA methyltransferase activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(7)|large_intestine(6)|lung(22)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(4)	55	Ovarian(103;0.0339)	all_cancers(173;0.00995)|Prostate(94;0.0115)|all_epithelial(177;0.172)	OV - Ovarian serous cystadenocarcinoma(106;0.000263)			GTTGCAAAAAAGAAATGCTCC	0.373000													10	25					0	0	1	0	0
ZNF131	7690	broad.mit.edu	37	5	43122225	43122225	+	Silent	SNP	T	T	C			TCGA-K4-A4AB-01B-12D-A289-08	TCGA-K4-A4AB-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4b6e6192-477f-484a-bfe6-811d252fcc92	71d2241d-fa8b-4e1d-8f55-fdff8143f572	g.chr5:43122225T>C	ENST00000509634.1	+	1	526	c.70T>C	c.(70-72)Ttg>Ctg	p.L24L	ZNF131_ENST00000306938.4_Silent_p.L24L|ZNF131_ENST00000399534.1_Silent_p.L24L|ZNF131_ENST00000509156.1_Silent_p.L24L|ZNF131_ENST00000505606.2_Silent_p.L24L|ZNF131_ENST00000509931.1_Silent_p.L24L			P52739	ZN131_HUMAN	zinc finger protein 131	24						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(2)|endometrium(2)|kidney(1)|lung(9)|ovary(1)|prostate(1)|urinary_tract(1)	17						CCTCGACCGATTGAATGAACA	0.507000													40	46					0	0	1	0	0
CUTC	51076	broad.mit.edu	37	10	101515429	101515429	+	Missense_Mutation	SNP	C	C	G			TCGA-K4-A4AB-01B-12D-A289-08	TCGA-K4-A4AB-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4b6e6192-477f-484a-bfe6-811d252fcc92	71d2241d-fa8b-4e1d-8f55-fdff8143f572	g.chr10:101515429C>G	ENST00000370476.5	+	9	884	c.755C>G	c.(754-756)tCc>tGc	p.S252C		NM_015960.2	NP_057044.2	Q9NTM9	CUTC_HUMAN	cutC copper transporter	252					copper ion homeostasis|copper ion transport|protein tetramerization	cytoplasm|nucleus	copper ion binding			breast(2)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(5)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	14		Colorectal(252;0.234)		Epithelial(162;3e-10)|all cancers(201;2.37e-08)		TCAGAATATTCCCTAAAGGTA	0.408000													12	11					0	0	1	0	0
DPYD	1806	broad.mit.edu	37	1	98015254	98015254	+	Silent	SNP	T	T	C			TCGA-K4-A4AB-01B-12D-A289-08	TCGA-K4-A4AB-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4b6e6192-477f-484a-bfe6-811d252fcc92	71d2241d-fa8b-4e1d-8f55-fdff8143f572	g.chr1:98015254T>C	ENST00000370192.3	-	12	1486	c.1386A>G	c.(1384-1386)ccA>ccG	p.P462P		NM_000110.3	NP_000101	Q12882	DPYD_HUMAN	dihydropyrimidine dehydrogenase	462					'de novo' pyrimidine base biosynthetic process|purine base catabolic process|thymidine catabolic process|thymine catabolic process|UMP biosynthetic process|uracil catabolic process	cytosol	4 iron, 4 sulfur cluster binding|dihydroorotate oxidase activity|dihydropyrimidine dehydrogenase (NADP+) activity|electron carrier activity|flavin adenine dinucleotide binding|metal ion binding|NADP binding|protein homodimerization activity	p.P462P(1)		NS(2)|breast(4)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(18)|lung(30)|ovary(4)|prostate(6)|skin(7)|upper_aerodigestive_tract(1)	83		all_epithelial(167;0.000185)|all_lung(203;0.00318)|Lung NSC(277;0.00994)		Colorectal(170;0.0165)|Epithelial(280;0.0526)|all cancers(265;0.104)|READ - Rectum adenocarcinoma(84;0.171)|Lung(183;0.216)	Capecitabine(DB01101)|Enfuvirtide(DB00109)	GATCTACTTCTGGGAGACCCC	0.398000													10	37					0	0	1	0	0
CEP104	9731	broad.mit.edu	37	1	3745892	3745892	+	Missense_Mutation	SNP	C	C	G			TCGA-K4-A4AB-01B-12D-A289-08	TCGA-K4-A4AB-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4b6e6192-477f-484a-bfe6-811d252fcc92	71d2241d-fa8b-4e1d-8f55-fdff8143f572	g.chr1:3745892C>G	ENST00000378230.3	-	15	2413	c.2089G>C	c.(2089-2091)Gaa>Caa	p.E697Q		NM_014704.3	NP_055519.1	O60308	CE104_HUMAN	centrosomal protein 104kDa	697						centriole	binding			breast(2)|cervix(1)|endometrium(9)|kidney(1)|large_intestine(14)|lung(8)|prostate(1)|skin(3)	39						TTTATTTCTTCTTTCTTTTGT	0.393000													14	26					0	0	1	0	0
OR4N4	283694	broad.mit.edu	37	15	22383245	22383245	+	Missense_Mutation	SNP	A	A	G			TCGA-K4-A4AB-01B-12D-A289-08	TCGA-K4-A4AB-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4b6e6192-477f-484a-bfe6-811d252fcc92	71d2241d-fa8b-4e1d-8f55-fdff8143f572	g.chr15:22383245A>G	ENST00000328795.4	+	1	864	c.773A>G	c.(772-774)tAc>tGc	p.Y258C	RP11-69H14.6_ENST00000558896.1_RNA	NM_001005241.2	NP_001005241.2	Q8N0Y3	OR4N4_HUMAN	olfactory receptor, family 4, subfamily N, member 4	258					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(3)|kidney(3)|large_intestine(6)|lung(19)|ovary(4)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	40		all_cancers(20;1.94e-20)|all_epithelial(15;3.94e-18)|Lung NSC(15;8.53e-15)|all_lung(15;2.87e-14)|Breast(32;0.00519)|Colorectal(260;0.101)	GBM - Glioblastoma multiforme(6;0.124)	all cancers(64;1.64e-11)|Epithelial(43;5.81e-10)|BRCA - Breast invasive adenocarcinoma(123;0.000255)|Kidney(6;0.00736)|KIRC - Kidney renal clear cell carcinoma(6;0.0135)|GBM - Glioblastoma multiforme(186;0.0963)		ATCTTCATCTACATGTGCCCT	0.448000													49	138					0	0	1	0	0
GHSR	2693	broad.mit.edu	37	3	172165526	172165526	+	Silent	SNP	G	G	A			TCGA-K4-A4AB-01B-12D-A289-08	TCGA-K4-A4AB-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4b6e6192-477f-484a-bfe6-811d252fcc92	71d2241d-fa8b-4e1d-8f55-fdff8143f572	g.chr3:172165526G>A	ENST00000241256.2	-	1	720	c.678C>T	c.(676-678)ttC>ttT	p.F226F	GHSR_ENST00000427970.1_Silent_p.F226F	NM_198407.2	NP_940799.1	Q92847	GHSR_HUMAN	growth hormone secretagogue receptor	226					actin polymerization or depolymerization|adult feeding behavior|decidualization|growth hormone secretion|hormone-mediated signaling pathway|negative regulation of inflammatory response|negative regulation of interleukin-1 beta production|negative regulation of interleukin-6 biosynthetic process|negative regulation of tumor necrosis factor biosynthetic process|positive regulation of appetite|positive regulation of multicellular organism growth	cell surface|integral to membrane|membrane raft|neuron projection|plasma membrane	growth hormone secretagogue receptor activity|growth hormone-releasing hormone receptor activity			biliary_tract(1)|breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(6)|lung(16)|ovary(2)|prostate(3)|skin(1)|urinary_tract(1)	33	Ovarian(172;0.00143)|Breast(254;0.197)		Lung(28;3.93e-15)|LUSC - Lung squamous cell carcinoma(14;1.48e-14)|STAD - Stomach adenocarcinoma(35;0.235)			CCGTGAGACAGAAGACAGGAA	0.622000													26	70					0	0	1	0	0
LCORL	254251	broad.mit.edu	37	4	17847521	17847521	+	Missense_Mutation	SNP	C	C	A			TCGA-K4-A4AB-01B-12D-A289-08	TCGA-K4-A4AB-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4b6e6192-477f-484a-bfe6-811d252fcc92	71d2241d-fa8b-4e1d-8f55-fdff8143f572	g.chr4:17847521C>A	ENST00000326877.4	-	7	904	c.780G>T	c.(778-780)atG>atT	p.M260I	LCORL_ENST00000539056.1_Missense_Mutation_p.C142F	NM_153686.7	NP_710153.2	Q8N3X6	LCORL_HUMAN	ligand dependent nuclear receptor corepressor-like						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			kidney(1)|large_intestine(1)|lung(1)|prostate(1)	4						TCACTTGTAGCATGCTGGAAG	0.353000													36	70					1.36615e-20	1.53174e-20	1	1	0
STAP2	55620	broad.mit.edu	37	19	4333721	4333721	+	Silent	SNP	C	C	T			TCGA-K4-A4AB-01B-12D-A289-08	TCGA-K4-A4AB-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4b6e6192-477f-484a-bfe6-811d252fcc92	71d2241d-fa8b-4e1d-8f55-fdff8143f572	g.chr19:4333721C>T	ENST00000600324.1	-	3	334	c.267G>A	c.(265-267)ctG>ctA	p.L89L	STAP2_ENST00000594605.1_Silent_p.L89L	NM_017720.2	NP_060190.2	Q9UGK3	STAP2_HUMAN	signal transducing adaptor family member 2	89	PH.					cytoplasm|nucleus	protein binding			central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(10)	23		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0339)|STAD - Stomach adenocarcinoma(1328;0.18)		CCCGGAGAATCAGGCTGAAGT	0.567000													35	61					0	0	1	0	0
CYP11B1	1584	broad.mit.edu	37	8	143958156	143958156	+	Missense_Mutation	SNP	C	C	G			TCGA-K4-A4AB-01B-12D-A289-08	TCGA-K4-A4AB-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4b6e6192-477f-484a-bfe6-811d252fcc92	71d2241d-fa8b-4e1d-8f55-fdff8143f572	g.chr8:143958156C>G	ENST00000292427.4	-	4	773	c.741G>C	c.(739-741)tgG>tgC	p.W247C	CYP11B1_ENST00000377675.3_Missense_Mutation_p.W318C|CYP11B1_ENST00000517471.1_Missense_Mutation_p.W247C	NM_000497.3	NP_000488.3	P15538	C11B1_HUMAN	cytochrome P450, family 11, subfamily B, polypeptide 1	247					aldosterone biosynthetic process|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|glucose homeostasis|immune response|regulation of blood pressure|response to stress|xenobiotic metabolic process	mitochondrial inner membrane	electron carrier activity|steroid 11-beta-monooxygenase activity			central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(10)|lung(36)|ovary(4)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)	67	all_cancers(97;4.74e-11)|all_epithelial(106;2.06e-08)|Lung NSC(106;0.000228)|all_lung(105;0.000633)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)				Mitotane(DB00648)	TGGGGCTGGTCCAGCGAGACA	0.607000									Familial Hyperaldosteronism type I				16	50					0	0	1	0	0
WDR78	79819	broad.mit.edu	37	1	67299711	67299711	+	Missense_Mutation	SNP	G	G	C			TCGA-K4-A4AB-01B-12D-A289-08	TCGA-K4-A4AB-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4b6e6192-477f-484a-bfe6-811d252fcc92	71d2241d-fa8b-4e1d-8f55-fdff8143f572	g.chr1:67299711G>C	ENST00000371026.3	-	12	1909	c.1854C>G	c.(1852-1854)atC>atG	p.I618M	WDR78_ENST00000431318.1_Missense_Mutation_p.I364M	NM_024763.4	NP_079039.4	Q5VTH9	WDR78_HUMAN	WD repeat domain 78	618										NS(1)|endometrium(3)|kidney(6)|large_intestine(6)|lung(10)|ovary(3)|skin(3)	32						CCCATTTGGAGATTCTTCCAT	0.353000													11	31					0	0	1	0	0
NOVA1	4857	broad.mit.edu	37	14	26918047	26918047	+	Silent	SNP	G	G	A			TCGA-K4-A4AB-01B-12D-A289-08	TCGA-K4-A4AB-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4b6e6192-477f-484a-bfe6-811d252fcc92	71d2241d-fa8b-4e1d-8f55-fdff8143f572	g.chr14:26918047G>A	ENST00000539517.2	-	5	959	c.642C>T	c.(640-642)atC>atT	p.I214I	NOVA1_ENST00000267422.7_Silent_p.I92I|NOVA1_ENST00000465357.2_Silent_p.I190I	NM_002515.2	NP_002506.2	P51513	NOVA1_HUMAN	neuro-oncological ventral antigen 1	217	KH 2.				locomotory behavior|RNA splicing|synaptic transmission	nucleus	RNA binding	p.I214I(1)		breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(9)|liver(1)|lung(19)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	40				GBM - Glioblastoma multiforme(265;0.0135)		CTTGCAAGTTGATCCCATCAG	0.488000													57	115					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9069856	9069856	+	Nonsense_Mutation	SNP	G	G	A			TCGA-K4-A4AB-01B-12D-A289-08	TCGA-K4-A4AB-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4b6e6192-477f-484a-bfe6-811d252fcc92	71d2241d-fa8b-4e1d-8f55-fdff8143f572	g.chr19:9069856G>A	ENST00000397910.4	-	3	17793	c.17590C>T	c.(17590-17592)Caa>Taa	p.Q5864*		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	5866	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GGACCTGTTTGGTTGGTGATG	0.483000													66	90					0	0	1	0	0
ZNF746	155061	broad.mit.edu	37	7	149174803	149174803	+	Missense_Mutation	SNP	G	G	C			TCGA-K4-A4AB-01B-12D-A289-08	TCGA-K4-A4AB-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4b6e6192-477f-484a-bfe6-811d252fcc92	71d2241d-fa8b-4e1d-8f55-fdff8143f572	g.chr7:149174803G>C	ENST00000340622.3	-	5	844	c.564C>G	c.(562-564)atC>atG	p.I188M	ZNF746_ENST00000458143.2_Missense_Mutation_p.I188M			Q6NUN9	ZN746_HUMAN	zinc finger protein 746	188					negative regulation of transcription, DNA-dependent|neuron death|regulation of cell death|transcription, DNA-dependent	cytoplasm|nucleus	transcription regulatory region DNA binding|ubiquitin protein ligase binding|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(5)|large_intestine(4)|lung(11)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	34	Melanoma(164;0.165)		OV - Ovarian serous cystadenocarcinoma(82;0.00358)			CCTCCTGCTTGATCTGCATCA	0.667000													24	24					0	0	1	0	0
TBX10	347853	broad.mit.edu	37	11	67402342	67402342	+	Silent	SNP	G	G	A			TCGA-K4-A4AB-01B-12D-A289-08	TCGA-K4-A4AB-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4b6e6192-477f-484a-bfe6-811d252fcc92	71d2241d-fa8b-4e1d-8f55-fdff8143f572	g.chr11:67402342G>A	ENST00000335385.3	-	3	409	c.322C>T	c.(322-324)Ctg>Ttg	p.L108L		NM_005995.4	NP_005986.2	O75333	TBX10_HUMAN	T-box 10	108					anatomical structure morphogenesis|regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(2)|lung(4)|ovary(1)	7						TAGTCGGCCAGGGAGTCCATG	0.657000													29	50					0	0	1	0	0
CNOT1	23019	broad.mit.edu	37	16	58589197	58589197	+	Missense_Mutation	SNP	A	A	G			TCGA-K4-A4AB-01B-12D-A289-08	TCGA-K4-A4AB-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4b6e6192-477f-484a-bfe6-811d252fcc92	71d2241d-fa8b-4e1d-8f55-fdff8143f572	g.chr16:58589197A>G	ENST00000317147.5	-	21	3181	c.2849T>C	c.(2848-2850)aTg>aCg	p.M950T	CNOT1_ENST00000569732.1_5'UTR|CNOT1_ENST00000441024.2_Missense_Mutation_p.M950T|CNOT1_ENST00000569240.1_Missense_Mutation_p.M945T	NM_001265612.1|NM_016284.4	NP_001252541.1|NP_057368.3	A5YKK6	CNOT1_HUMAN	CCR4-NOT transcription complex, subunit 1	950					nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol				breast(1)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(24)|lung(25)|ovary(4)|prostate(6)|skin(3)|upper_aerodigestive_tract(2)	87				Kidney(780;0.0722)|OV - Ovarian serous cystadenocarcinoma(108;0.173)|Epithelial(162;0.239)		GAAATAATACATTTTGGATCC	0.433000													36	137					0	0	1	0	0
CYBA	1535	broad.mit.edu	37	16	88713227	88713227	+	Missense_Mutation	SNP	C	C	T	rs13306293		TCGA-K4-A4AB-01B-12D-A289-08	TCGA-K4-A4AB-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4b6e6192-477f-484a-bfe6-811d252fcc92	71d2241d-fa8b-4e1d-8f55-fdff8143f572	g.chr16:88713227C>T	ENST00000569359.1	-	4	239	c.223G>A	c.(223-225)Gcc>Acc	p.A75T	CYBA_ENST00000567174.1_Missense_Mutation_p.A75T|CYBA_ENST00000261623.3_Missense_Mutation_p.A75T			P13498	CY24A_HUMAN	cytochrome b-245, alpha polypeptide	75					cytochrome complex assembly|electron transport chain|hydrogen peroxide biosynthetic process|inflammatory response|innate immune response|respiratory burst|smooth muscle hypertrophy|superoxide anion generation|transport	NADPH oxidase complex|stored secretory granule	electron carrier activity|heme binding|protein heterodimerization activity|SH3 domain binding			endometrium(1)|liver(1)	2				BRCA - Breast invasive adenocarcinoma(80;0.0478)		TTCACCACGGCGGTCATGTAC	0.652000													62	69					0	0	1	0	0
SNX33	257364	broad.mit.edu	37	15	75941703	75941703	+	Missense_Mutation	SNP	G	G	A			TCGA-K4-A4AB-01B-12D-A289-08	TCGA-K4-A4AB-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4b6e6192-477f-484a-bfe6-811d252fcc92	71d2241d-fa8b-4e1d-8f55-fdff8143f572	g.chr15:75941703G>A	ENST00000308527.5	+	1	1457	c.260G>A	c.(259-261)aGc>aAc	p.S87N		NM_153271.1	NP_695003.1	Q8WV41	SNX33_HUMAN	sorting nexin 33	87					cell communication		phosphatidylinositol binding|protein binding			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(3)|ovary(1)|prostate(1)|soft_tissue(1)|urinary_tract(2)	19						TTGTACAACAGCCCCAGTGTG	0.582000													37	27					0	0	1	0	0
FOXP1	27086	broad.mit.edu	37	3	71096092	71096092	+	Splice_Site	SNP	C	C	T			TCGA-K4-A4AB-01B-12D-A289-08	TCGA-K4-A4AB-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4b6e6192-477f-484a-bfe6-811d252fcc92	71d2241d-fa8b-4e1d-8f55-fdff8143f572	g.chr3:71096092C>T	ENST00000318789.4	-	10	1190		c.e10+1		FOXP1_ENST00000484350.1_Splice_Site|FOXP1_ENST00000491238.1_Splice_Site|FOXP1_ENST00000493089.1_Splice_Site|FOXP1_ENST00000472382.1_Splice_Site|FOXP1_ENST00000468577.1_Splice_Site|FOXP1_ENST00000498215.1_Splice_Site|FOXP1_ENST00000475937.1_Splice_Site	NM_001244810.1|NM_001244813.1|NM_032682.5	NP_001231739.1|NP_001231742.1|NP_116071.2	Q9H334	FOXP1_HUMAN	forkhead box P1						cardiac muscle cell differentiation|embryo development|immunoglobulin V(D)J recombination|pattern specification process|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of immunoglobulin production|positive regulation of mesenchymal cell proliferation|pre-B cell differentiation|regulation of sequence-specific DNA binding transcription factor activity|skeletal muscle tissue development|smooth muscle tissue development	cytoplasm|transcription factor complex	chromatin binding|DNA bending activity|double-stranded DNA binding|promoter binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|zinc ion binding			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(7)|lung(8)|ovary(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	31		Lung NSC(201;4.62e-05)|Prostate(10;0.0181)|Hepatocellular(537;0.186)|Myeloproliferative disorder(1037;0.209)		BRCA - Breast invasive adenocarcinoma(55;1.17e-05)|Epithelial(33;1.39e-05)|LUSC - Lung squamous cell carcinoma(21;2.35e-05)|Lung(16;4.26e-05)		TCAACGCATACCTTGAGCAAG	0.507000			T	PAX5	ALL								100	199					0	0	1	0	0
JADE3	9767	broad.mit.edu	37	X	46898446	46898446	+	Missense_Mutation	SNP	G	G	T			TCGA-K4-A4AB-01B-12D-A289-08	TCGA-K4-A4AB-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4b6e6192-477f-484a-bfe6-811d252fcc92	71d2241d-fa8b-4e1d-8f55-fdff8143f572	g.chrX:46898446G>T	ENST00000218343.4	+	8	1249	c.951G>T	c.(949-951)ttG>ttT	p.L317F	PHF16_ENST00000397189.1_Missense_Mutation_p.L317F	NM_014735.3	NP_055550.1	Q92613	JADE3_HUMAN		317					histone H3 acetylation|histone H4-K12 acetylation|histone H4-K5 acetylation|histone H4-K8 acetylation	histone acetyltransferase complex	zinc ion binding			NS(2)|endometrium(8)|kidney(4)|large_intestine(5)|lung(12)|upper_aerodigestive_tract(2)	33						TGTGCAAGTTGAAGACGGGGG	0.532000													28	6					6.32553e-13	6.88367e-13	1	1	0
TOP3B	8940	broad.mit.edu	37	22	22324718	22324718	+	Missense_Mutation	SNP	G	G	A			TCGA-K4-A4AB-01B-12D-A289-08	TCGA-K4-A4AB-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4b6e6192-477f-484a-bfe6-811d252fcc92	71d2241d-fa8b-4e1d-8f55-fdff8143f572	g.chr22:22324718G>A	ENST00000398793.2	-	6	879	c.445C>T	c.(445-447)Cgg>Tgg	p.R149W	TOP3B_ENST00000357179.5_Missense_Mutation_p.R149W|TOP3B_ENST00000413067.2_Intron	NM_003935.3	NP_003926.1	O95985	TOP3B_HUMAN	topoisomerase (DNA) III beta	149	Toprim.				DNA topological change	nucleus	ATP binding|DNA topoisomerase type I activity|protein binding			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(4)|lung(9)|ovary(1)	26	Colorectal(54;0.105)			READ - Rectum adenocarcinoma(21;0.145)		AACCTGGCCCGGAACACGGTC	0.607000													19	43					0	0	1	0	0
TPSD1	23430	broad.mit.edu	37	16	1308104	1308104	+	Missense_Mutation	SNP	G	G	A			TCGA-K4-A4AB-01B-12D-A289-08	TCGA-K4-A4AB-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4b6e6192-477f-484a-bfe6-811d252fcc92	71d2241d-fa8b-4e1d-8f55-fdff8143f572	g.chr16:1308104G>A	ENST00000211076.3	+	4	713	c.565G>A	c.(565-567)Gta>Ata	p.V189I	TPSD1_ENST00000397534.2_Missense_Mutation_p.V182I	NM_012217.2	NP_036349.1	Q9BZJ3	TRYD_HUMAN	tryptase delta 1	189	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(9)|skin(1)|stomach(2)|upper_aerodigestive_tract(3)	20		Hepatocellular(780;0.00369)				GGAAGTCCCCGTAGTGGAAAA	0.652000													14	14					0	0	1	0	0
MOXD1	26002	broad.mit.edu	37	6	132643910	132643910	+	Missense_Mutation	SNP	C	C	A			TCGA-K4-A4AB-01B-12D-A289-08	TCGA-K4-A4AB-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4b6e6192-477f-484a-bfe6-811d252fcc92	71d2241d-fa8b-4e1d-8f55-fdff8143f572	g.chr6:132643910C>A	ENST00000367963.3	-	8	1331	c.1213G>T	c.(1213-1215)Ggg>Tgg	p.G405W	MOXD1_ENST00000489128.1_5'UTR|MOXD1_ENST00000336749.3_Missense_Mutation_p.G337W	NM_015529.2	NP_056344.2	Q6UVY6	MOXD1_HUMAN	monooxygenase, DBH-like 1	405					catecholamine metabolic process	endoplasmic reticulum membrane|integral to membrane	copper ion binding|dopamine beta-monooxygenase activity			breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(15)|ovary(1)|prostate(3)|skin(1)	37	Breast(56;0.0495)			OV - Ovarian serous cystadenocarcinoma(155;0.0132)|GBM - Glioblastoma multiforme(226;0.0191)		ATTTCCTTCCCTTTTCGAAAA	0.428000													18	26					1.02788e-11	1.10237e-11	1	1	0
NACA	4666	broad.mit.edu	37	12	57118263	57118263	+	Missense_Mutation	SNP	C	C	T			TCGA-K4-A4AB-01B-12D-A289-08	TCGA-K4-A4AB-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4b6e6192-477f-484a-bfe6-811d252fcc92	71d2241d-fa8b-4e1d-8f55-fdff8143f572	g.chr12:57118263C>T	ENST00000454682.1	-	2	324	c.43G>A	c.(43-45)Gag>Aag	p.E15K	NACA_ENST00000393891.4_Missense_Mutation_p.E15K|NACA_ENST00000548563.1_5'UTR|NACA_ENST00000356769.3_Missense_Mutation_p.E15K|NACA_ENST00000550952.1_Missense_Mutation_p.E15K|NACA_ENST00000552540.1_Missense_Mutation_p.E15K|NACA_ENST00000551793.1_5'UTR|NACA_ENST00000546392.1_Missense_Mutation_p.E15K	NM_001113203.2	NP_001106674.2	Q13765	NACA_HUMAN	nascent polypeptide-associated complex alpha subunit	15					interspecies interaction between organisms|protein transport|transcription, DNA-dependent|translation	nascent polypeptide-associated complex|nucleus	DNA binding			breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(1)|ovary(2)|upper_aerodigestive_tract(1)	10						TGCGGCAACTCCTGCTCTGTA	0.498000			T	BCL6	NHL								18	5					0	0	1	0	0
SPINK7	84651	broad.mit.edu	37	5	147693762	147693762	+	Missense_Mutation	SNP	G	G	C			TCGA-K4-A4AB-01B-12D-A289-08	TCGA-K4-A4AB-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4b6e6192-477f-484a-bfe6-811d252fcc92	71d2241d-fa8b-4e1d-8f55-fdff8143f572	g.chr5:147693762G>C	ENST00000274565.4	+	3	248	c.187G>C	c.(187-189)Gaa>Caa	p.E63Q	RP11-373N22.3_ENST00000501695.3_RNA|SPINK7_ENST00000523535.1_Missense_Mutation_p.E37Q|SPINK7_ENST00000514394.1_3'UTR	NM_032566.2	NP_115955.1	P58062	ISK7_HUMAN	serine peptidase inhibitor, Kazal type 7 (putative)	63	Kazal-like.					extracellular region	protein binding|serine-type endopeptidase inhibitor activity			large_intestine(2)|lung(3)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTATGGGAATGAATGTCACTT	0.468000													25	77					0	0	1	0	0
TTC7B	145567	broad.mit.edu	37	14	91044554	91044554	+	Missense_Mutation	SNP	G	G	A			TCGA-K4-A4AB-01B-12D-A289-08	TCGA-K4-A4AB-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4b6e6192-477f-484a-bfe6-811d252fcc92	71d2241d-fa8b-4e1d-8f55-fdff8143f572	g.chr14:91044554G>A	ENST00000357056.2	-	20	2378	c.2257C>T	c.(2257-2259)Cgc>Tgc	p.R753C	TTC7B_ENST00000328459.6_Missense_Mutation_p.R736C|TTC7B_ENST00000554654.1_5'UTR			Q86TV6	TTC7B_HUMAN	tetratricopeptide repeat domain 7B	736							binding			NS(1)|breast(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(8)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)	36		Melanoma(154;0.222)				ATCTGGCCGCGCATGTAGAGG	0.592000													21	34					0	0	1	0	0
SLFN5	162394	broad.mit.edu	37	17	33592292	33592292	+	Missense_Mutation	SNP	G	G	T			TCGA-K4-A4AB-01B-12D-A289-08	TCGA-K4-A4AB-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4b6e6192-477f-484a-bfe6-811d252fcc92	71d2241d-fa8b-4e1d-8f55-fdff8143f572	g.chr17:33592292G>T	ENST00000299977.4	+	5	2209	c.2061G>T	c.(2059-2061)caG>caT	p.Q687H	SLFN5_ENST00000542451.1_3'UTR	NM_144975.3	NP_659412.3	Q08AF3	SLFN5_HUMAN	schlafen family member 5	687					cell differentiation		ATP binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(3)|large_intestine(8)|liver(2)|lung(6)|ovary(1)|prostate(5)|skin(1)|upper_aerodigestive_tract(2)	34		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0191)		ACTACTTTCAGACCTATCACT	0.502000													36	91					4.4194e-11	4.70555e-11	1	1	0
GRIN2D	2906	broad.mit.edu	37	19	48946603	48946603	+	Silent	SNP	G	G	A			TCGA-K4-A4AB-01B-12D-A289-08	TCGA-K4-A4AB-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4b6e6192-477f-484a-bfe6-811d252fcc92	71d2241d-fa8b-4e1d-8f55-fdff8143f572	g.chr19:48946603G>A	ENST00000263269.3	+	13	3508	c.3420G>A	c.(3418-3420)ccG>ccA	p.P1140P		NM_000836.2	NP_000827.2	O15399	NMDE4_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 2D	1140						cell junction|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|protein binding			autonomic_ganglia(1)|breast(6)|endometrium(2)|large_intestine(9)|lung(12)|ovary(5)|pancreas(1)|prostate(1)	37		all_epithelial(76;1.11e-06)|all_lung(116;5.79e-06)|Lung NSC(112;1.18e-05)|all_neural(266;0.0189)|Ovarian(192;0.0261)|Breast(70;0.203)		all cancers(93;0.00014)|OV - Ovarian serous cystadenocarcinoma(262;0.000233)|Epithelial(262;0.0112)|GBM - Glioblastoma multiforme(486;0.0161)	L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Orphenadrine(DB01173)	TCCCTTACCCGTATGCCGAGC	0.751000													11	18					0	0	1	0	0
LOR	4014	broad.mit.edu	37	1	153233497	153233497	+	Silent	SNP	C	C	T	rs67787963		TCGA-K4-A4AB-01B-12D-A289-08	TCGA-K4-A4AB-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4b6e6192-477f-484a-bfe6-811d252fcc92	71d2241d-fa8b-4e1d-8f55-fdff8143f572	g.chr1:153233497C>T	ENST00000368742.3	+	2	129	c.72C>T	c.(70-72)ggC>ggT	p.G24G		NM_000427.2	NP_000418.2	P23490	LORI_HUMAN	loricrin	24					keratinization|peptide cross-linking	cornified envelope|cytoplasm|insoluble fraction|nucleoplasm	protein binding, bridging|structural constituent of cytoskeleton			lung(2)	2	all_lung(78;3.35e-32)|Lung NSC(65;1.22e-30)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.171)			gcggcggtggcggtggcggcg	0.682000													4	52					0	0	1	0	0
OR4N4	283694	broad.mit.edu	37	15	22383258	22383258	+	Silent	SNP	C	C	T			TCGA-K4-A4AB-01B-12D-A289-08	TCGA-K4-A4AB-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4b6e6192-477f-484a-bfe6-811d252fcc92	71d2241d-fa8b-4e1d-8f55-fdff8143f572	g.chr15:22383258C>T	ENST00000328795.4	+	1	877	c.786C>T	c.(784-786)ttC>ttT	p.F262F	RP11-69H14.6_ENST00000558896.1_RNA	NM_001005241.2	NP_001005241.2	Q8N0Y3	OR4N4_HUMAN	olfactory receptor, family 4, subfamily N, member 4	262					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(3)|kidney(3)|large_intestine(6)|lung(19)|ovary(4)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	40		all_cancers(20;1.94e-20)|all_epithelial(15;3.94e-18)|Lung NSC(15;8.53e-15)|all_lung(15;2.87e-14)|Breast(32;0.00519)|Colorectal(260;0.101)	GBM - Glioblastoma multiforme(6;0.124)	all cancers(64;1.64e-11)|Epithelial(43;5.81e-10)|BRCA - Breast invasive adenocarcinoma(123;0.000255)|Kidney(6;0.00736)|KIRC - Kidney renal clear cell carcinoma(6;0.0135)|GBM - Glioblastoma multiforme(186;0.0963)		TGTGCCCTTTCAGGGCCTTAC	0.433000													44	144					0	0	1	0	0
GOLGA3	2802	broad.mit.edu	37	12	133358998	133358998	+	Missense_Mutation	SNP	C	C	T	rs151069773		TCGA-K4-A4AB-01B-12D-A289-08	TCGA-K4-A4AB-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4b6e6192-477f-484a-bfe6-811d252fcc92	71d2241d-fa8b-4e1d-8f55-fdff8143f572	g.chr12:133358998C>T	ENST00000204726.3	-	17	3907	c.3349G>A	c.(3349-3351)Gag>Aag	p.E1117K	GOLGA3_ENST00000456883.2_Missense_Mutation_p.E1117K|GOLGA3_ENST00000450791.2_Missense_Mutation_p.E1117K	NM_005895.3	NP_005886.2	Q08378	GOGA3_HUMAN	golgin A3	1117					intra-Golgi vesicle-mediated transport	Golgi cisterna membrane|Golgi transport complex	protein binding|transporter activity			breast(1)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(4)|lung(33)|ovary(3)|pancreas(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	64	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0176)|Lung NSC(355;0.204)		OV - Ovarian serous cystadenocarcinoma(86;2.27e-08)|Epithelial(86;3.34e-07)|all cancers(50;9.4e-06)		TTCCCTTTCTCGTGCTCTAAT	0.488000													57	97					0	0	1	0	0
BMS1P20	96610	broad.mit.edu	37	22	22664115	22664115	+	RNA	SNP	A	A	T			TCGA-K4-A4AB-01B-12D-A289-08	TCGA-K4-A4AB-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4b6e6192-477f-484a-bfe6-811d252fcc92	71d2241d-fa8b-4e1d-8f55-fdff8143f572	g.chr22:22664115A>T	ENST00000426066.1	+	0	638					NR_027293.1																						TGTTTAATTCAGCCTTGGAAG	0.413000													5	74					0	0	1	0	0
TP53	7157	broad.mit.edu	37	17	7578431	7578431	+	Nonsense_Mutation	SNP	G	G	A			TCGA-K4-A4AB-01B-12D-A289-08	TCGA-K4-A4AB-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4b6e6192-477f-484a-bfe6-811d252fcc92	71d2241d-fa8b-4e1d-8f55-fdff8143f572	g.chr17:7578431G>A	ENST00000420246.2	-	5	631	c.499C>T	c.(499-501)Cag>Tag	p.Q167*	TP53_ENST00000359597.4_Nonsense_Mutation_p.Q167*|TP53_ENST00000574684.1_5'UTR|TP53_ENST00000269305.4_Nonsense_Mutation_p.Q167*|TP53_ENST00000413465.2_Nonsense_Mutation_p.Q167*|TP53_ENST00000455263.2_Nonsense_Mutation_p.Q167*|TP53_ENST00000445888.2_Nonsense_Mutation_p.Q167*	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	167	Interaction with AXIN1 (By similarity).|Interaction with HIPK1 (By similarity).|Required for interaction with FBXO42.		Q -> H (in sporadic cancers; somatic mutation).|Q -> K (in LFS; germline mutation and in a sporadic cancer; somatic mutation).|Q -> L (in sporadic cancers; somatic mutation).|Q -> R (in sporadic cancers; somatic mutation).|QH -> HD (in a sporadic cancer; somatic mutation).|QH -> YL (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.Q167*(23)|p.0?(8)|p.Q167fs*13(3)|p.Q167fs*14(2)|p.Q167fs*3(2)|p.K164fs*3(2)|p.V157_C176del20(1)|p.Q167_H168>YL(1)|p.Q167K(1)|p.Y163fs*1(1)|p.Q167fs*12(1)|p.P151_V173del23(1)|p.Q165_M169delQSQHM(1)|p.Q167del(1)|p.S149fs*72(1)|p.A159_Q167delAMAIYKQSQ(1)|p.Q74*(1)|p.Q167E(1)|p.Q35*(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GTCATGTGCTGTGACTGCTTG	0.642000		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			78	27					0	0	1	0	0
ARHGAP39	80728	broad.mit.edu	37	8	145773809	145773809	+	Missense_Mutation	SNP	C	C	T			TCGA-K4-A4AB-01B-12D-A289-08	TCGA-K4-A4AB-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4b6e6192-477f-484a-bfe6-811d252fcc92	71d2241d-fa8b-4e1d-8f55-fdff8143f572	g.chr8:145773809C>T	ENST00000276826.5	-	4	862	c.661G>A	c.(661-663)Gag>Aag	p.E221K	ARHGAP39_ENST00000377307.2_Missense_Mutation_p.E221K|ARHGAP39_ENST00000540274.1_Missense_Mutation_p.E221K			Q9C0H5	RHG39_HUMAN	Rho GTPase activating protein 39	221					axon guidance|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytoskeleton|cytosol|nucleus	GTPase activator activity			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(11)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	22						AAGCTGGGCTCCCGATCAGCG	0.701000													29	48					0	0	1	0	0
LINC00969	440993	broad.mit.edu	37	3	195400728	195400728	+	RNA	SNP	A	A	G	rs12107841	by1000genomes	TCGA-K4-A4AB-01B-12D-A289-08	TCGA-K4-A4AB-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4b6e6192-477f-484a-bfe6-811d252fcc92	71d2241d-fa8b-4e1d-8f55-fdff8143f572	g.chr3:195400728A>G	ENST00000445430.1	+	0	1324																											GATTGTGCCCAGCCTGTACGC	0.587000													4	28					0	0	1	0	0
SERPINB3	6317	broad.mit.edu	37	18	61328328	61328328	+	Silent	SNP	G	G	A			TCGA-K4-A4AB-01B-12D-A289-08	TCGA-K4-A4AB-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4b6e6192-477f-484a-bfe6-811d252fcc92	71d2241d-fa8b-4e1d-8f55-fdff8143f572	g.chr18:61328328G>A	ENST00000283752.5	-	2	266	c.123C>T	c.(121-123)gtC>gtT	p.V41V	SERPINB11_ENST00000489748.1_RNA|SERPINB3_ENST00000332821.8_Silent_p.V41V	NM_006919.2	NP_008850.1	P29508	SPB3_HUMAN	serpin peptidase inhibitor, clade B (ovalbumin), member 3	41					regulation of proteolysis	cytoplasm|extracellular region	protein binding|serine-type endopeptidase inhibitor activity			breast(2)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(4)|lung(14)|ovary(1)|skin(5)|upper_aerodigestive_tract(2)	36						CTCCTAAGAGGACCATCCCTA	0.428000													41	74					0	0	1	0	0
OR5L2	26338	broad.mit.edu	37	11	55595241	55595241	+	Missense_Mutation	SNP	C	C	T			TCGA-K4-A4AB-01B-12D-A289-08	TCGA-K4-A4AB-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4b6e6192-477f-484a-bfe6-811d252fcc92	71d2241d-fa8b-4e1d-8f55-fdff8143f572	g.chr11:55595241C>T	ENST00000378397.1	+	1	547	c.547C>T	c.(547-549)Cct>Tct	p.P183S		NM_001004739.1	NP_001004739.1	Q8NGL0	OR5L2_HUMAN	olfactory receptor, family 5, subfamily L, member 2	183					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|kidney(1)|large_intestine(1)|lung(42)|ovary(1)|prostate(3)|skin(1)|stomach(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	59		all_epithelial(135;0.208)				TGATCTACCCCCTCTCCTAAG	0.458000										HNSCC(27;0.073)			70	119					0	0	1	0	0
QKI	9444	broad.mit.edu	37	6	163983040	163983040	+	Silent	SNP	G	G	A			TCGA-K4-A4AB-01B-12D-A289-08	TCGA-K4-A4AB-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4b6e6192-477f-484a-bfe6-811d252fcc92	71d2241d-fa8b-4e1d-8f55-fdff8143f572	g.chr6:163983040G>A	ENST00000361752.3	+	5	1124	c.573G>A	c.(571-573)aaG>aaA	p.K191K	QKI_ENST00000392127.2_Silent_p.K191K|QKI_ENST00000424802.3_Silent_p.K191K|QKI_ENST00000453779.2_Silent_p.K191K|QKI_ENST00000275262.7_Silent_p.K191K|QKI_ENST00000361195.2_Silent_p.K191K	NM_006775.2|NM_206853.2|NM_206854.2|NM_206855.2	NP_006766.1|NP_996735.1|NP_996736.1|NP_996737.1	Q96PU8	QKI_HUMAN	QKI, KH domain containing, RNA binding	191					mRNA processing|mRNA transport|regulation of translation|RNA splicing	cytoplasm|nucleus|plasma membrane	RNA binding|SH3 domain binding			central_nervous_system(1)|endometrium(2)|large_intestine(13)|lung(5)|ovary(1)|prostate(3)|urinary_tract(2)	27		Breast(66;5e-05)|Prostate(117;0.0235)|all_neural(5;0.0416)|Ovarian(120;0.0448)|Glioma(2;0.203)		all cancers(1;4.4e-46)|OV - Ovarian serous cystadenocarcinoma(33;6.91e-23)|GBM - Glioblastoma multiforme(1;2.94e-19)|BRCA - Breast invasive adenocarcinoma(81;1.49e-06)|Kidney(3;0.000199)|KIRC - Kidney renal clear cell carcinoma(3;0.000234)		GCCTGAAGAAGATGCAGCTGA	0.438000													22	31					0	0	1	0	0
CCDC39	339829	broad.mit.edu	37	3	180359830	180359830	+	Missense_Mutation	SNP	T	T	C			TCGA-K4-A4AB-01B-12D-A289-08	TCGA-K4-A4AB-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4b6e6192-477f-484a-bfe6-811d252fcc92	71d2241d-fa8b-4e1d-8f55-fdff8143f572	g.chr3:180359830T>C	ENST00000273654.4	-	19	2696	c.2077A>G	c.(2077-2079)Atg>Gtg	p.M693V	CCDC39_ENST00000442201.2_Missense_Mutation_p.M609V			Q9UFE4	CCD39_HUMAN	coiled-coil domain containing 39	609					axonemal dynein complex assembly|ciliary cell motility|cilium movement involved in determination of left/right asymmetry|flagellar cell motility	cilium axoneme|cytoplasm|cytoskeleton				NS(1)|breast(1)|endometrium(4)|large_intestine(9)|lung(22)|ovary(6)|prostate(2)	45	all_cancers(143;9.31e-15)|Ovarian(172;0.0212)		OV - Ovarian serous cystadenocarcinoma(80;5.62e-23)|GBM - Glioblastoma multiforme(14;0.000558)			GACGCAAGCATTGTTTTATGA	0.343000													14	49					0	0	1	0	0
ZNF418	147686	broad.mit.edu	37	19	58439152	58439152	+	Missense_Mutation	SNP	C	C	T			TCGA-K4-A4AB-01B-12D-A289-08	TCGA-K4-A4AB-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4b6e6192-477f-484a-bfe6-811d252fcc92	71d2241d-fa8b-4e1d-8f55-fdff8143f572	g.chr19:58439152C>T	ENST00000396147.1	-	4	688	c.397G>A	c.(397-399)Gga>Aga	p.G133R	ZNF418_ENST00000595830.1_Missense_Mutation_p.G133R|ZNF418_ENST00000599852.1_Missense_Mutation_p.G48R|ZNF418_ENST00000600989.1_Intron|ZNF418_ENST00000425570.3_Missense_Mutation_p.G154R	NM_133460.1	NP_597717.1	Q8TF45	ZN418_HUMAN	zinc finger protein 418	133					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			cervix(1)|endometrium(6)|kidney(1)|large_intestine(6)|lung(9)|prostate(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	31		Colorectal(82;0.000256)|all_neural(62;0.0577)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0158)		GGTTTCTCTCCAAGGTACTGA	0.448000													109	108					0	0	1	0	0
PDZD7	79955	broad.mit.edu	37	10	102778773	102778773	+	Missense_Mutation	SNP	C	C	T			TCGA-K4-A4AB-01B-12D-A289-08	TCGA-K4-A4AB-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4b6e6192-477f-484a-bfe6-811d252fcc92	71d2241d-fa8b-4e1d-8f55-fdff8143f572	g.chr10:102778773C>T	ENST00000370215.3	-	8	1355	c.1130G>A	c.(1129-1131)gGa>gAa	p.G377E		NM_024895.4	NP_079171.1	Q9H5P4	PDZD7_HUMAN	PDZ domain containing 7	377						cilium|nucleus	protein binding			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(5)|lung(7)|ovary(2)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	22				Epithelial(162;6.98e-09)|all cancers(201;3.55e-07)		CACCCGGCCTCCCGCATCGGG	0.736000											OREG0020453	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	6	7					0	0	1	0	0
KDM6A	7403	broad.mit.edu	37	X	44942821	44942821	+	Missense_Mutation	SNP	T	T	C			TCGA-K4-A4AB-01B-12D-A289-08	TCGA-K4-A4AB-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4b6e6192-477f-484a-bfe6-811d252fcc92	71d2241d-fa8b-4e1d-8f55-fdff8143f572	g.chrX:44942821T>C	ENST00000377967.4	+	23	3442	c.3401T>C	c.(3400-3402)cTa>cCa	p.L1134P	KDM6A_ENST00000543216.1_Missense_Mutation_p.L1055P|KDM6A_ENST00000382899.4_Missense_Mutation_p.L1141P|KDM6A_ENST00000536777.1_Missense_Mutation_p.L1089P	NM_021140.2	NP_066963.2	O15550	KDM6A_HUMAN	lysine (K)-specific demethylase 6A	1134	JmjC.				histone H3-K4 methylation		metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	p.0?(6)		NS(1)|breast(7)|central_nervous_system(27)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(24)|kidney(24)|large_intestine(9)|liver(1)|lung(21)|oesophagus(11)|pancreas(2)|prostate(5)|skin(1)|soft_tissue(1)|urinary_tract(29)	170						ACAGTTCAACTATACATGAAA	0.373000			"""D, N, F, S"""		"""renal, oesophageal SCC, MM"""								17	8					0	0	1	0	0
SLTM	79811	broad.mit.edu	37	15	59205829	59205829	+	Nonsense_Mutation	SNP	C	C	A			TCGA-K4-A4AB-01B-12D-A289-08	TCGA-K4-A4AB-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4b6e6192-477f-484a-bfe6-811d252fcc92	71d2241d-fa8b-4e1d-8f55-fdff8143f572	g.chr15:59205829C>A	ENST00000380516.2	-	4	469	c.382G>T	c.(382-384)Gaa>Taa	p.E128*	SLTM_ENST00000536328.1_5'UTR|SLTM_ENST00000557950.1_5'UTR	NM_001013843.1|NM_024755.2	NP_001013865.1|NP_079031.2	Q9NWH9	SLTM_HUMAN	SAFB-like, transcription modulator	128	Glu-rich.				apoptosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleotide binding|RNA binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(9)|lung(10)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	28						TCACCAAATTCTTCAGAGTCC	0.368000													24	35					1.10513e-12	1.19387e-12	1	1	0
CDH5	1003	broad.mit.edu	37	16	66434798	66434798	+	Silent	SNP	C	C	T	rs112348868		TCGA-K4-A4AB-01B-12D-A289-08	TCGA-K4-A4AB-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4b6e6192-477f-484a-bfe6-811d252fcc92	71d2241d-fa8b-4e1d-8f55-fdff8143f572	g.chr16:66434798C>T	ENST00000341529.3	+	11	1864	c.1716C>T	c.(1714-1716)acC>acT	p.T572T	CDH5_ENST00000539168.1_Silent_p.T11T	NM_001795.3	NP_001786.2	P33151	CADH5_HUMAN	cadherin 5, type 2 (vascular endothelium)	572	Cadherin 5.				adherens junction organization|cell junction assembly|homophilic cell adhesion|regulation of establishment of cell polarity	integral to membrane|membrane fraction	beta-catenin binding|calcium ion binding|ion channel binding|receptor binding			central_nervous_system(1)|endometrium(3)|kidney(18)|large_intestine(2)|lung(17)|ovary(2)|prostate(5)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	54		Ovarian(137;0.0955)		OV - Ovarian serous cystadenocarcinoma(108;0.107)		GCACGCTGACCGTGGCCGTGT	0.602000													78	91					0	0	1	0	0
ESR1	2099	broad.mit.edu	37	6	152265629	152265629	+	Missense_Mutation	SNP	C	C	A			TCGA-K4-A4AB-01B-12D-A289-08	TCGA-K4-A4AB-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4b6e6192-477f-484a-bfe6-811d252fcc92	71d2241d-fa8b-4e1d-8f55-fdff8143f572	g.chr6:152265629C>A	ENST00000440973.1	+	6	1452	c.1082C>A	c.(1081-1083)gCg>gAg	p.A361E	ESR1_ENST00000206249.3_Missense_Mutation_p.A361E|ESR1_ENST00000338799.5_Missense_Mutation_p.A361E|ESR1_ENST00000443427.1_Missense_Mutation_p.A361E|ESR1_ENST00000482101.1_3'UTR|ESR1_ENST00000406599.1_Intron|ESR1_ENST00000427531.2_Missense_Mutation_p.A188E|ESR1_ENST00000456483.2_Intron	NM_001122742.1	NP_001116214.1	P03372	ESR1_HUMAN	estrogen receptor 1	361	Interaction with AKAP13.|Steroid-binding.				positive regulation of retinoic acid receptor signaling pathway|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to estradiol stimulus	chromatin remodeling complex|cytoplasm|nucleoplasm	beta-catenin binding|enzyme binding|estrogen receptor activity|estrogen response element binding|nitric-oxide synthase regulator activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(9)|kidney(1)|large_intestine(11)|lung(19)|ovary(1)|prostate(2)|skin(1)	49		Ovarian(120;0.0448)	BRCA - Breast invasive adenocarcinoma(37;0.0841)	OV - Ovarian serous cystadenocarcinoma(155;4.55e-10)	Chlorotrianisene(DB00269)|Clomifene(DB00882)|Conjugated Estrogens(DB00286)|Danazol(DB01406)|Desogestrel(DB00304)|Dienestrol(DB00890)|Diethylstilbestrol(DB00255)|Dromostanolone(DB00858)|Drospirenone(DB01395)|Estradiol(DB00783)|Estramustine(DB01196)|Estriol(DB04573)|Estrone(DB00655)|Ethinyl Estradiol(DB00977)|Ethynodiol Diacetate(DB00823)|Etonogestrel(DB00294)|Fluoxymesterone(DB01185)|Fulvestrant(DB00947)|Letrozole(DB01006)|Levonorgestrel(DB00367)|Medroxyprogesterone(DB00603)|Megestrol(DB00351)|Melatonin(DB01065)|Mestranol(DB01357)|Naloxone(DB01183)|Norgestimate(DB00957)|Norgestrel(DB00506)|Progesterone(DB00396)|Quinestrol(DB04575)|Raloxifene(DB00481)|Tamoxifen(DB00675)|Toremifene(DB00539)	ATCAACTGGGCGAAGAGGGTG	0.478000													28	39					2.79863e-10	2.95855e-10	1	1	0
CAPN3	825	broad.mit.edu	37	15	42702646	42702646	+	Silent	SNP	C	C	A			TCGA-K4-A4AB-01B-12D-A289-08	TCGA-K4-A4AB-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4b6e6192-477f-484a-bfe6-811d252fcc92	71d2241d-fa8b-4e1d-8f55-fdff8143f572	g.chr15:42702646C>A	ENST00000397163.3	+	20	2355	c.2136C>A	c.(2134-2136)ctC>ctA	p.L712L	CAPN3_ENST00000356316.3_Silent_p.L619L|RP11-164J13.1_ENST00000495723.1_RNA|CAPN3_ENST00000337571.4_Silent_p.L47L|CAPN3_ENST00000561817.1_Silent_p.L47L|CAPN3_ENST00000562199.1_3'UTR|CAPN3_ENST00000357568.3_Silent_p.L706L|CAPN3_ENST00000397200.4_Silent_p.L200L|CAPN3_ENST00000569136.1_Silent_p.L47L|CAPN3_ENST00000349748.3_Silent_p.L620L|CAPN3_ENST00000318023.7_Silent_p.L706L|CAPN3_ENST00000397204.4_Silent_p.L47L	NM_000070.2	NP_000061.1	P20807	CAN3_HUMAN	calpain 3, (p94)	712	Domain IV.|EF-hand 2.				muscle organ development|proteolysis	cytoplasm	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity|signal transducer activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(8)|lung(21)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	47		all_cancers(109;1.65e-16)|all_epithelial(112;8.34e-15)|Lung NSC(122;3.56e-09)|all_lung(180;1.68e-08)|Melanoma(134;0.0574)|Colorectal(260;0.152)		GBM - Glioblastoma multiforme(94;7.36e-07)		CTGGAAAGCTCAACCTGCAGG	0.547000													46	35					1.6237e-14	1.78005e-14	1	1	0
LOC440040	440040	broad.mit.edu	37	11	49598273	49598273	+	RNA	SNP	A	A	G			TCGA-K4-A4AB-01B-12D-A289-08	TCGA-K4-A4AB-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4b6e6192-477f-484a-bfe6-811d252fcc92	71d2241d-fa8b-4e1d-8f55-fdff8143f572	g.chr11:49598273A>G	ENST00000527477.1	+	0	877																											ATTCAGGTCCAGAATTTGCTC	0.478000													18	33					0	0	1	0	0
KCNH2	3757	broad.mit.edu	37	7	150647314	150647314	+	Silent	SNP	G	G	A			TCGA-K4-A4AB-01B-12D-A289-08	TCGA-K4-A4AB-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4b6e6192-477f-484a-bfe6-811d252fcc92	71d2241d-fa8b-4e1d-8f55-fdff8143f572	g.chr7:150647314G>A	ENST00000392968.2	-	7	3172	c.2052C>T	c.(2050-2052)taC>taT	p.Y684Y	KCNH2_ENST00000262186.5_Silent_p.Y780Y|KCNH2_ENST00000430723.3_Silent_p.Y780Y|KCNH2_ENST00000330883.4_Silent_p.Y440Y			Q12809	KCNH2_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 2	780					blood circulation|muscle contraction|regulation of heart contraction|regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|two-component sensor activity			NS(1)|cervix(1)|endometrium(10)|kidney(1)|large_intestine(5)|lung(14)|ovary(1)|prostate(2)|skin(6)|upper_aerodigestive_tract(1)	42	all_neural(206;0.219)		OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)	Amiodarone(DB01118)|Amsacrine(DB00276)|Astemizole(DB00637)|Carvedilol(DB01136)|Cisapride(DB00604)|Dofetilide(DB00204)|Halofantrine(DB01218)|Ibutilide(DB00308)|Pimozide(DB01100)|Propafenone(DB01182)|Quinidine(DB00908)|Sertindole(DB06144)|Sotalol(DB00489)|Terfenadine(DB00342)|Verapamil(DB00661)	GGGAGATGAAGTACAGGGCGG	0.657000													45	92					0	0	1	0	0
OR5AS1	219447	broad.mit.edu	37	11	55798315	55798315	+	Missense_Mutation	SNP	T	T	C			TCGA-K4-A4AB-01B-12D-A289-08	TCGA-K4-A4AB-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4b6e6192-477f-484a-bfe6-811d252fcc92	71d2241d-fa8b-4e1d-8f55-fdff8143f572	g.chr11:55798315T>C	ENST00000313555.1	+	1	421	c.421T>C	c.(421-423)Tgt>Cgt	p.C141R		NM_001001921.1	NP_001001921.1	Q8N127	O5AS1_HUMAN	olfactory receptor, family 5, subfamily AS, member 1	141					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(7)|large_intestine(7)|liver(1)|lung(22)|ovary(3)|prostate(4)|skin(3)|stomach(1)	48	Esophageal squamous(21;0.00693)					TAGGAGAGTCTGTGTCTGCTT	0.478000													11	106					0	0	1	0	0
NAA11	84779	broad.mit.edu	37	4	80246702	80246702	+	Silent	SNP	G	G	A			TCGA-K4-A4AB-01B-12D-A289-08	TCGA-K4-A4AB-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4b6e6192-477f-484a-bfe6-811d252fcc92	71d2241d-fa8b-4e1d-8f55-fdff8143f572	g.chr4:80246702G>A	ENST00000286794.4	-	1	502	c.330C>T	c.(328-330)caC>caT	p.H110H		NM_032693.2	NP_116082.1	Q9BSU3	NAA11_HUMAN	N(alpha)-acetyltransferase 11, NatA catalytic subunit	110	N-acetyltransferase.					cytoplasm|nucleus	peptide alpha-N-acetyltransferase activity|protein binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|large_intestine(4)|lung(9)|ovary(1)|pancreas(1)|skin(2)	23						TCTTCCTGACGTGCAGAGACA	0.522000													26	48					0	0	1	0	0
PCDHA10	56139	broad.mit.edu	37	5	140237280	140237280	+	Silent	SNP	G	G	A			TCGA-K4-A4AB-01B-12D-A289-08	TCGA-K4-A4AB-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4b6e6192-477f-484a-bfe6-811d252fcc92	71d2241d-fa8b-4e1d-8f55-fdff8143f572	g.chr5:140237280G>A	ENST00000307360.5	+	1	1647	c.1647G>A	c.(1645-1647)acG>acA	p.T549T	PCDHA3_ENST00000522353.2_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA10_ENST00000506939.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA4_ENST00000530339.1_Intron	NM_018901.2	NP_061724.1														NS(1)|breast(11)|cervix(1)|endometrium(11)|kidney(5)|large_intestine(13)|liver(2)|lung(20)|ovary(3)|pancreas(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(2)	79			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCAACTTGACGCTGCAGGTGT	0.687000													34	122					0	0	1	0	0
ATP10A	57194	broad.mit.edu	37	15	25940040	25940040	+	Missense_Mutation	SNP	C	C	A			TCGA-K4-A4AB-01B-12D-A289-08	TCGA-K4-A4AB-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4b6e6192-477f-484a-bfe6-811d252fcc92	71d2241d-fa8b-4e1d-8f55-fdff8143f572	g.chr15:25940040C>A	ENST00000356865.6	-	14	3125	c.3014G>T	c.(3013-3015)cGg>cTg	p.R1005L		NM_024490.3	NP_077816.1	O60312	AT10A_HUMAN	ATPase, class V, type 10A	1005					ATP biosynthetic process|regulation of cell shape	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			NS(1)|breast(2)|endometrium(8)|kidney(2)|large_intestine(33)|liver(1)|lung(41)|ovary(3)|pancreas(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(2)	103		all_cancers(20;5.16e-25)|all_lung(180;1.51e-14)|Acute lymphoblastic leukemia(1;2.53e-05)|all_hematologic(1;0.000267)|Breast(32;0.00125)		all cancers(64;9.48e-07)|Epithelial(43;1.69e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0252)|Lung(196;0.244)		AGGCGTCGACCGACAGCAGAG	0.597000													21	47					8.10497e-08	8.50735e-08	1	1	0
C11orf45	219833	broad.mit.edu	37	11	128774378	128774378	+	Silent	SNP	C	C	T			TCGA-K4-A4AB-01B-12D-A289-08	TCGA-K4-A4AB-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4b6e6192-477f-484a-bfe6-811d252fcc92	71d2241d-fa8b-4e1d-8f55-fdff8143f572	g.chr11:128774378C>T	ENST00000310799.3	-	2	277	c.84G>A	c.(82-84)ctG>ctA	p.L28L	C11orf45_ENST00000530168.1_5'UTR|KCNJ5_ENST00000338350.4_Intron|KCNJ5_ENST00000529694.1_Intron|C11orf45_ENST00000524878.1_Silent_p.L28L	NM_001256088.1|NM_145013.2	NP_001243017.1|NP_659450.1	Q8TAV5	CK045_HUMAN	chromosome 11 open reading frame 45	28						extracellular region				endometrium(1)|kidney(1)|lung(2)|pancreas(1)|prostate(2)	7	all_hematologic(175;0.0641)	Lung NSC(97;0.00521)|Breast(109;0.00715)|all_lung(97;0.0111)|Medulloblastoma(222;0.0523)|all_neural(223;0.186)		OV - Ovarian serous cystadenocarcinoma(99;0.00531)|LUSC - Lung squamous cell carcinoma(976;0.0193)|Lung(977;0.0195)		gcacgttgtccagctcccagc	0.587000													45	36					0	0	1	0	0
WBP2NL	164684	broad.mit.edu	37	22	42394846	42394846	+	Silent	SNP	C	C	T			TCGA-K4-A4AB-01B-12D-A289-08	TCGA-K4-A4AB-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4b6e6192-477f-484a-bfe6-811d252fcc92	71d2241d-fa8b-4e1d-8f55-fdff8143f572	g.chr22:42394846C>T	ENST00000328823.9	+	1	55	c.24C>T	c.(22-24)acC>acT	p.T8T	WBP2NL_ENST00000461730.1_3'UTR	NM_152613.2	NP_689826.2	Q6ICG8	WBP2L_HUMAN	WBP2 N-terminal like	8					egg activation|male pronucleus assembly|meiosis	perinuclear theca	WW domain binding			breast(2)|large_intestine(3)|lung(5)|ovary(3)|prostate(1)	14						AGAGCCACACCGAGAACCGCC	0.647000													10	10					0	0	1	0	0
ELK1	2002	broad.mit.edu	37	X	47500685	47500685	+	Silent	SNP	C	C	T			TCGA-K4-A4AB-01B-12D-A289-08	TCGA-K4-A4AB-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4b6e6192-477f-484a-bfe6-811d252fcc92	71d2241d-fa8b-4e1d-8f55-fdff8143f572	g.chrX:47500685C>T	ENST00000247161.3	-	2	255	c.156G>A	c.(154-156)aaG>aaA	p.K52K	ELK1_ENST00000376983.3_Silent_p.K52K|ELK1_ENST00000592066.1_5'UTR|ELK1_ENST00000343894.4_Silent_p.K52K	NM_005229.4	NP_005220.2	P19419	ELK1_HUMAN	ELK1, member of ETS oncogene family	52					innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway		protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(2)|ovary(2)|skin(2)	10						TCATGTTGGTCTTGTTCTTGC	0.552000													30	9					0	0	1	0	0
OSGIN1	29948	broad.mit.edu	37	16	83999057	83999057	+	Silent	SNP	G	G	A			TCGA-K4-A4AB-01B-12D-A289-08	TCGA-K4-A4AB-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4b6e6192-477f-484a-bfe6-811d252fcc92	71d2241d-fa8b-4e1d-8f55-fdff8143f572	g.chr16:83999057G>A	ENST00000343939.2	+	7	1511	c.1128G>A	c.(1126-1128)gcG>gcA	p.A376A	OSGIN1_ENST00000361711.3_Silent_p.A293A|OSGIN1_ENST00000393306.1_Silent_p.A293A			Q9UJX0	OSGI1_HUMAN	oxidative stress induced growth inhibitor 1	376					cell differentiation|multicellular organismal development|negative regulation of cell growth		growth factor activity			autonomic_ganglia(1)|large_intestine(1)|lung(7)|prostate(2)|upper_aerodigestive_tract(1)	12						TCATTGGCGCGGGGCTGTCAG	0.682000													73	50					0	0	1	0	0
APOA1BP	128240	broad.mit.edu	37	1	156561719	156561719	+	Silent	SNP	G	G	A			TCGA-K4-A4AB-01B-12D-A289-08	TCGA-K4-A4AB-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4b6e6192-477f-484a-bfe6-811d252fcc92	71d2241d-fa8b-4e1d-8f55-fdff8143f572	g.chr1:156561719G>A	ENST00000368235.3	+	1	166	c.123G>A	c.(121-123)ctG>ctA	p.L41L	APOA1BP_ENST00000368234.3_Silent_p.L41L|APOA1BP_ENST00000368233.3_Silent_p.L41L|APOA1BP_ENST00000467374.1_3'UTR	NM_144772.2	NP_658985.2	Q8NCW5	AIBP_HUMAN	apolipoprotein A-I binding protein	41						extracellular region	protein binding			central_nervous_system(1)|large_intestine(2)|lung(3)|prostate(2)|urinary_tract(1)	9	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					CGCAGCGGCTGAACTCGGGTG	0.706000													34	40					0	0	1	0	0
PNPLA5	150379	broad.mit.edu	37	22	44282275	44282275	+	Nonsense_Mutation	SNP	C	C	T			TCGA-K4-A4AB-01B-12D-A289-08	TCGA-K4-A4AB-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4b6e6192-477f-484a-bfe6-811d252fcc92	71d2241d-fa8b-4e1d-8f55-fdff8143f572	g.chr22:44282275C>T	ENST00000216177.4	-	6	989	c.857G>A	c.(856-858)tGg>tAg	p.W286*	PNPLA5_ENST00000381198.2_Nonsense_Mutation_p.W172*|PNPLA5_ENST00000597664.1_Nonsense_Mutation_p.W286*|PNPLA5_ENST00000593866.1_Nonsense_Mutation_p.W172*	NM_138814.3	NP_620169.1	Q7Z6Z6	PLPL5_HUMAN	patatin-like phospholipase domain containing 5	286			W -> R (in dbSNP:rs739231).		lipid catabolic process		hydrolase activity			endometrium(3)|kidney(1)|large_intestine(3)|lung(8)|ovary(1)	16		all_neural(38;0.0966)|Ovarian(80;0.105)|Glioma(61;0.222)				GCCCCCCTTCCAGCGTTGGTC	0.592000													30	65					0	0	1	0	0
MTHFD2	10797	broad.mit.edu	37	2	74432963	74432964	+	Frame_Shift_Ins	INS	-	-	T			TCGA-K4-A4AB-01B-12D-A289-08	TCGA-K4-A4AB-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4b6e6192-477f-484a-bfe6-811d252fcc92	71d2241d-fa8b-4e1d-8f55-fdff8143f572	g.chr2:74432963_74432964insT	ENST00000394053.2	+	2	313_314	c.233_234insT	c.(232-237)aatcctfs	p.P79fs	MTHFD2_ENST00000409601.1_Frame_Shift_Ins_p.P79fs|MTHFD2_ENST00000394050.3_Intron|MTHFD2_ENST00000264090.4_Intron|MTHFD2_ENST00000477455.1_3'UTR|MTHFD2_ENST00000409804.1_Frame_Shift_Ins_p.P79fs	NM_006636.3	NP_006627.2	P13995	MTDC_HUMAN	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase	79					folic acid-containing compound biosynthetic process|one-carbon metabolic process|tetrahydrofolate metabolic process	mitochondrion	magnesium ion binding|methenyltetrahydrofolate cyclohydrolase activity|methylenetetrahydrofolate dehydrogenase (NAD+) activity|methylenetetrahydrofolate dehydrogenase (NADP+) activity|phosphate binding|protein binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(3)	6					NADH(DB00157)|Tetrahydrofolic acid(DB00116)	GTTGGCGAGAATCCTGCAAGTC	0.545													92	43	---	---	---	---					
FAM170A	340069	broad.mit.edu	37	5	118970191	118970191	+	Frame_Shift_Del	DEL	G	G	-			TCGA-K4-A4AB-01B-12D-A289-08	TCGA-K4-A4AB-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4b6e6192-477f-484a-bfe6-811d252fcc92	71d2241d-fa8b-4e1d-8f55-fdff8143f572	g.chr5:118970191delG	ENST00000515256.1	+	3	920	c.748delG	c.(748-750)gggfs	p.G250fs				A1A519	F170A_HUMAN	family with sequence similarity 170, member A	250						intracellular	zinc ion binding			breast(2)|endometrium(1)|kidney(2)|large_intestine(6)|lung(7)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	24						TGTGCAGTTTGGGATCAGAGA	0.577													31	224	---	---	---	---					
ADCK5	203054	broad.mit.edu	37	8	145617535	145617549	+	Splice_Site	DEL	GGGGGTGCAAGGTGA	GGGGGTGCAAGGTGA	-	rs11270020		TCGA-K4-A4AB-01B-12D-A289-08	TCGA-K4-A4AB-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4b6e6192-477f-484a-bfe6-811d252fcc92	71d2241d-fa8b-4e1d-8f55-fdff8143f572	g.chr8:145617535_145617549delGGGGGTGCAAGGTGA	ENST00000308860.6	+	12	1301_1311	c.1257_1267delGGGGGTGCAAGGTGA	c.(1255-1269)ctgggggtgcaaggt>ctgt	p.GVQG420del		NM_174922.3	NP_777582.4	Q3MIX3	ADCK5_HUMAN	aarF domain containing kinase 5	420						integral to membrane	protein serine/threonine kinase activity	p.?(2)		endometrium(1)|lung(2)|prostate(2)|skin(1)|stomach(2)	8	all_cancers(97;6.64e-12)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;8.96e-41)|Epithelial(56;4.08e-40)|all cancers(56;4.51e-35)|BRCA - Breast invasive adenocarcinoma(115;0.0323)|Colorectal(110;0.055)			CAGCCGCACTGGGGGTGCAAGGTGAGGGGGTGCAA	0.730													4	3	---	---	---	---					
C9orf117	286207	broad.mit.edu	37	9	130472879	130472879	+	Splice_Site	DEL	G	G	-			TCGA-K4-A4AB-01B-12D-A289-08	TCGA-K4-A4AB-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4b6e6192-477f-484a-bfe6-811d252fcc92	71d2241d-fa8b-4e1d-8f55-fdff8143f572	g.chr9:130472879delG	ENST00000373295.2	+	3	473		c.e3-1			NM_001012502.2	NP_001012520.2	Q5JU67	CI117_HUMAN	chromosome 9 open reading frame 117											breast(1)|kidney(1)|large_intestine(1)|lung(2)|prostate(1)	6						GTGGCGGCCAGGGGGGAAGCT	0.617													2	4	---	---	---	---					
TSPAN4	7106	broad.mit.edu	37	11	864443	864445	+	In_Frame_Del	DEL	CTG	CTG	-	rs61867552	byFrequency	TCGA-K4-A4AB-01B-12D-A289-08	TCGA-K4-A4AB-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4b6e6192-477f-484a-bfe6-811d252fcc92	71d2241d-fa8b-4e1d-8f55-fdff8143f572	g.chr11:864443_864445delCTG	ENST00000397404.1	+	5	521_523	c.262_264delCTG	c.(262-264)ctgdel	p.L92del	TSPAN4_ENST00000397396.1_In_Frame_Del_p.L28del|TSPAN4_ENST00000397397.2_In_Frame_Del_p.L92del|TSPAN4_ENST00000397411.2_In_Frame_Del_p.L92del|TSPAN4_ENST00000525201.1_In_Frame_Del_p.L28del|TSPAN4_ENST00000409531.1_In_Frame_Del_p.L111del|TSPAN4_ENST00000346501.4_In_Frame_Del_p.L92del|TSPAN4_ENST00000397408.1_In_Frame_Del_p.L92del|TSPAN4_ENST00000409543.2_In_Frame_Del_p.L92del|TSPAN4_ENST00000397406.1_In_Frame_Del_p.L92del	NM_001025237.1	NP_001020408.1	O14817	TSN4_HUMAN	tetraspanin 4	92					protein complex assembly	integral to plasma membrane				breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)	3		all_cancers(49;2.64e-08)|all_epithelial(84;4.17e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.191)|all_lung(207;0.24)		all cancers(45;4.32e-25)|Epithelial(43;3.29e-24)|BRCA - Breast invasive adenocarcinoma(625;4.23e-05)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)		ACAGTTCTTCCTGCTGCTGCTGC	0.650													7	162	---	---	---	---					
RBM10	8241	broad.mit.edu	37	X	47041234	47041238	+	Frame_Shift_Del	DEL	CCCCA	CCCCA	-	rs11551151		TCGA-K4-A4AB-01B-12D-A289-08	TCGA-K4-A4AB-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4b6e6192-477f-484a-bfe6-811d252fcc92	71d2241d-fa8b-4e1d-8f55-fdff8143f572	g.chrX:47041234_47041238delCCCCA	ENST00000377604.3	+	15	2404_2408	c.1662_1666delCCCCA	c.(1660-1668)agccccactfs	p.PT555fs	RBM10_ENST00000345781.6_Frame_Shift_Del_p.PT478fs|RBM10_ENST00000329236.7_Frame_Shift_Del_p.PT477fs	NM_001204467.1|NM_001204468.1|NM_005676.4	NP_001191396.1|NP_001191397.1|NP_005667.2	P98175	RBM10_HUMAN	RNA binding motif protein 10	555					mRNA processing|RNA splicing	chromatin remodeling complex	nucleotide binding|RNA binding|zinc ion binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(8)|large_intestine(10)|liver(1)|lung(14)|ovary(2)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	48						CGGCTACCAGCCCCACTGCCCAGGA	0.580													21	18	---	---	---	---					
GAGE2D	729408	broad.mit.edu	37	X	49208295	49208296	+	In_Frame_Ins	INS	-	-	TAT			TCGA-K4-A4AB-01B-12D-A289-08	TCGA-K4-A4AB-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4b6e6192-477f-484a-bfe6-811d252fcc92	71d2241d-fa8b-4e1d-8f55-fdff8143f572	g.chrX:49208295_49208296insTAT	ENST00000404720.2	+	2	96_97	c.24_25insTAT	c.(25-27)tat>TATtat	p.9_9Y>YY		NM_001098407.1|NM_012196.1	NP_001091877.1|NP_036328.1			G antigen 2D																		GAAGATCGACCTATCGGCCTAG	0.465													6	6	---	---	---	---