Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
RSPH6A	81492	broad.mit.edu	37	19	46303729	46303729	+	Missense_Mutation	SNP	C	C	T			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr19:46303729C>T	ENST00000221538.3	-	5	2033	c.1891G>A	c.(1891-1893)Ggg>Agg	p.G631R	RSPH6A_ENST00000597055.1_Missense_Mutation_p.G631R|RSPH6A_ENST00000600188.1_Missense_Mutation_p.G367R	NM_030785.3	NP_110412.1	Q9H0K4	RSH6A_HUMAN	radial spoke head 6 homolog A (Chlamydomonas)	631	Glu-rich.					intracellular				central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(6)|liver(1)|lung(14)|ovary(2)|prostate(1)|skin(1)|urinary_tract(2)	32						GCATAGGCCCCGGGCCAGAGG	0.627000													30	23					0	0	1	0	0
ZNF284	342909	broad.mit.edu	37	19	44590904	44590904	+	Missense_Mutation	SNP	G	G	C			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr19:44590904G>C	ENST00000421176.3	+	5	1489	c.1273G>C	c.(1273-1275)Gaa>Caa	p.E425Q	ZNF223_ENST00000591793.1_3'UTR	NM_001037813.2	NP_001032902.1	Q2VY69	ZN284_HUMAN	zinc finger protein 284	425					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|kidney(2)|large_intestine(6)|lung(4)|upper_aerodigestive_tract(1)	15		Prostate(69;0.0435)				TAGAGAAGAAGAACTGTATAA	0.423000													31	110					0	0	1	0	0
POM121	9883	broad.mit.edu	37	7	72412579	72412579	+	Nonsense_Mutation	SNP	C	C	T			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr7:72412579C>T	ENST00000395270.1	+	14	2293	c.1252C>T	c.(1252-1254)Cag>Tag	p.Q418*	POM121_ENST00000257622.4_Nonsense_Mutation_p.Q418*|POM121_ENST00000446813.1_Nonsense_Mutation_p.Q418*|POM121_ENST00000434423.2_Nonsense_Mutation_p.Q683*|POM121_ENST00000358357.3_Nonsense_Mutation_p.Q418*	NM_001257190.1	NP_001244119.1	Q96HA1	P121A_HUMAN	POM121 transmembrane nucleoporin	683	Pore side (Potential).|Ser-rich.				carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	endoplasmic reticulum membrane|nuclear membrane|nuclear pore				NS(1)|breast(1)|endometrium(9)|kidney(4)|large_intestine(6)|lung(12)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	41		Lung NSC(55;0.163)				TCCAACCCTTCAGGCAGAGAC	0.607000													5	89					0	0	1	0	0
CARD6	84674	broad.mit.edu	37	5	40843462	40843462	+	Silent	SNP	G	G	A			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr5:40843462G>A	ENST00000254691.5	+	2	691	c.492G>A	c.(490-492)aaG>aaA	p.K164K	CARD6_ENST00000381677.3_Silent_p.K164K	NM_032587.3	NP_115976.2	Q9BX69	CARD6_HUMAN	caspase recruitment domain family, member 6	164					apoptosis|regulation of apoptosis	intracellular				NS(1)|breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|liver(2)|lung(29)|ovary(2)|pancreas(1)|prostate(2)|skin(3)|urinary_tract(1)	62						CTGCCAGGAAGAATGAGAAGG	0.383000													9	32					0	0	1	0	0
TPSAB1	7177	broad.mit.edu	37	16	1291302	1291302	+	Silent	SNP	G	G	A			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr16:1291302G>A	ENST00000461509.2	+	2	425	c.231G>A	c.(229-231)ctG>ctA	p.L77L	TPSAB1_ENST00000338844.3_Silent_p.L70L			P20231	TRYB2_HUMAN	tryptase alpha/beta 1	70	Peptidase S1.				proteolysis	extracellular region	protein binding|serine-type endopeptidase activity	p.L70L(1)		NS(2)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(4)|skin(1)	10		Hepatocellular(780;0.00369)				AGTGGGTGCTGACCGCAGCGC	0.706000													5	58					0	0	1	0	0
ADAMTS12	81792	broad.mit.edu	37	5	33658336	33658336	+	Silent	SNP	A	A	G			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr5:33658336A>G	ENST00000504830.1	-	7	1478	c.1143T>C	c.(1141-1143)gaT>gaC	p.D381D	ADAMTS12_ENST00000352040.3_Silent_p.D381D|ADAMTS12_ENST00000504582.1_5'UTR	NM_030955.2	NP_112217.2	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 12	381	Peptidase M12B.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(7)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(11)|large_intestine(31)|liver(1)|lung(135)|ovary(4)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(5)	216						GGAGTCCCGAATCTTCATTGA	0.502000										HNSCC(64;0.19)			23	84					0	0	1	0	0
CEP97	79598	broad.mit.edu	37	3	101484276	101484276	+	Missense_Mutation	SNP	C	C	G			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr3:101484276C>G	ENST00000341893.3	+	11	3231	c.2479C>G	c.(2479-2481)Cct>Gct	p.P827A	CEP97_ENST00000327230.4_Missense_Mutation_p.P853A|CEP97_ENST00000494050.1_Missense_Mutation_p.P768A			Q8IW35	CEP97_HUMAN	centrosomal protein 97kDa	827						centrosome|nucleus	protein binding			cervix(1)|endometrium(2)|kidney(4)|large_intestine(4)|lung(13)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	29						CATATCTCCTCCTTTGCAAGG	0.413000													29	156					0	0	1	0	0
HTT	3064	broad.mit.edu	37	4	3117909	3117909	+	Silent	SNP	C	C	G			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr4:3117909C>G	ENST00000355072.5	+	8	1132	c.987C>G	c.(985-987)gtC>gtG	p.V329V		NM_002111.6	NP_002102	P42858	HD_HUMAN	huntingtin	329					establishment of mitotic spindle orientation|Golgi organization|retrograde vesicle-mediated transport, Golgi to ER|vesicle transport along microtubule	autophagic vacuole|axon|cytoplasmic vesicle membrane|cytosol|dendrite|endoplasmic reticulum|Golgi apparatus|late endosome|membrane fraction|nucleus|protein complex	beta-tubulin binding|dynactin binding|dynein intermediate chain binding|p53 binding|transcription factor binding			breast(1)|cervix(2)|endometrium(14)|kidney(5)|large_intestine(23)|lung(28)|ovary(4)|prostate(2)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	87		all_epithelial(65;0.18)		UCEC - Uterine corpus endometrioid carcinoma (64;0.187)		AGCAGCAGGTCAAGGACACAA	0.537000													26	156					0	0	1	0	0
EGR1	1958	broad.mit.edu	37	5	137802542	137802542	+	Missense_Mutation	SNP	G	G	A			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr5:137802542G>A	ENST00000239938.4	+	2	676	c.404G>A	c.(403-405)gGc>gAc	p.G135D		NM_001964.2	NP_001955.1	P18146	EGR1_HUMAN	early growth response 1	135					cellular response to heparin|cellular response to mycophenolic acid|glomerular mesangial cell proliferation|interleukin-1-mediated signaling pathway|positive regulation of glomerular metanephric mesangial cell proliferation|positive regulation of transcription from RNA polymerase II promoter|regulation of protein sumoylation|transcription from RNA polymerase II promoter|type I interferon-mediated signaling pathway	cytoplasm|nucleus	histone acetyltransferase binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|ovary(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.004)|Kidney(363;0.00592)			ACCTATACTGGCCGCTTTTCC	0.582000													75	61					0	0	1	0	0
SNHG1	23642	broad.mit.edu	37	11	62622490	62622490	+	RNA	SNP	C	C	A			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr11:62622490C>A	ENST00000363981.1	-	0	65					NR_002563.1																						TCTCACTTCTCAGTAGTAAGA	0.388000													19	100					0.000295444	0.000297821	1	1	0
DNAH17	8632	broad.mit.edu	37	17	76425363	76425363	+	Missense_Mutation	SNP	G	G	T			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr17:76425363G>T	ENST00000389840.5	-	76	12350	c.12226C>A	c.(12226-12228)Cgc>Agc	p.R4076S	DNAH17_ENST00000586052.1_5'UTR|DNAH17_ENST00000585328.1_Missense_Mutation_p.R4077S					dynein, axonemal, heavy chain 17											NS(2)|breast(7)|central_nervous_system(5)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(13)|large_intestine(8)|lung(37)|ovary(8)|prostate(7)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	116			BRCA - Breast invasive adenocarcinoma(99;0.00294)|OV - Ovarian serous cystadenocarcinoma(97;0.0656)			AAAAGGTAGCGGAGATCGTCC	0.592000													35	12					2.75727e-19	2.99652e-19	1	1	0
PDGFRA	5156	broad.mit.edu	37	4	55141141	55141141	+	Splice_Site	SNP	G	G	A			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr4:55141141G>A	ENST00000257290.5	+	12	2117		c.e12+1		FIP1L1_ENST00000507166.1_Splice_Site	NM_006206.4	NP_006197.1	P16234	PGFRA_HUMAN	platelet-derived growth factor receptor, alpha polypeptide						cardiac myofibril assembly|cell activation|luteinization|metanephric glomerular capillary formation|peptidyl-tyrosine phosphorylation|positive regulation of cell migration|positive regulation of DNA replication|positive regulation of fibroblast proliferation|protein autophosphorylation|retina vasculature development in camera-type eye	cytoplasm|integral to plasma membrane|nucleus	ATP binding|platelet-derived growth factor alpha-receptor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|protein homodimerization activity|vascular endothelial growth factor receptor activity			NS(1)|autonomic_ganglia(1)|bone(1)|breast(4)|central_nervous_system(17)|cervix(1)|endometrium(4)|eye(1)|gastrointestinal_tract_(site_indeterminate)(1)|haematopoietic_and_lymphoid_tissue(22)|kidney(6)|large_intestine(26)|liver(4)|lung(48)|ovary(4)|prostate(6)|skin(11)|small_intestine(49)|soft_tissue(727)|stomach(32)|urinary_tract(1)	967	all_cancers(7;0.000425)|all_lung(4;0.000343)|Lung NSC(11;0.000467)|all_epithelial(27;0.0131)|all_neural(26;0.0209)|Glioma(25;0.08)		GBM - Glioblastoma multiforme(1;4.18e-71)|all cancers(1;4.76e-45)|LUSC - Lung squamous cell carcinoma(32;0.00256)		Becaplermin(DB00102)|Imatinib(DB00619)|Sunitinib(DB01268)	CTAGTGCTTGGTAAGTTCCAT	0.448000			"""Mis, O, T"""	FIP1L1	"""GIST, idiopathic hypereosinophilic syndrome, paediatric GBM"""				Gastrointestinal Stromal Tumors, Sporadic Multiple Primary;Familial Intestinal Neurofibromatosis	TSP Lung(21;0.16)			30	25					0	0	1	0	0
ANAPC1	64682	broad.mit.edu	37	2	112541926	112541926	+	Missense_Mutation	SNP	G	G	A			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr2:112541926G>A	ENST00000341068.3	-	41	5741	c.4969C>T	c.(4969-4971)Ctt>Ttt	p.L1657F		NM_022662.3	NP_073153.1	Q9H1A4	APC1_HUMAN	anaphase promoting complex subunit 1	1657					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination	anaphase-promoting complex|cytosol|nucleoplasm				NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(6)|kidney(4)|large_intestine(7)|lung(16)|pancreas(1)|prostate(3)|skin(5)|stomach(1)|urinary_tract(1)	49						AGTTCTGGAAGAAGGGTAGGA	0.443000													10	45					0	0	1	0	0
DMXL2	23312	broad.mit.edu	37	15	51857288	51857288	+	Missense_Mutation	SNP	G	G	C			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr15:51857288G>C	ENST00000251076.5	-	4	648	c.361C>G	c.(361-363)Caa>Gaa	p.Q121E	DMXL2_ENST00000543779.2_Missense_Mutation_p.Q121E|DMXL2_ENST00000449909.3_Missense_Mutation_p.Q121E|DMXL2_ENST00000560421.1_5'UTR	NM_001174116.1|NM_015263.3	NP_001167587.1|NP_056078.2	Q8TDJ6	DMXL2_HUMAN	Dmx-like 2	121						cell junction|synaptic vesicle membrane	Rab GTPase binding			breast(4)|central_nervous_system(1)|cervix(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(26)|liver(1)|lung(28)|ovary(7)|prostate(7)|skin(4)|stomach(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	101				all cancers(107;0.00494)		TAAATACCTTGAGGATCCCAT	0.289000													7	4					0	0	1	0	0
HSP90AA1	3320	broad.mit.edu	37	14	102552188	102552188	+	Nonsense_Mutation	SNP	C	C	A			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr14:102552188C>A	ENST00000334701.7	-	4	1083	c.802G>T	c.(802-804)Gag>Tag	p.E268*	HSP90AA1_ENST00000216281.8_Nonsense_Mutation_p.E146*|HSP90AA1_ENST00000441629.2_Intron	NM_001017963.2	NP_001017963.2	P07900	HS90A_HUMAN	heat shock protein 90kDa alpha (cytosolic), class A member 1	146					axon guidance|cellular chaperone-mediated protein complex assembly|G2/M transition of mitotic cell cycle|nitric oxide metabolic process|positive regulation of nitric oxide biosynthetic process|protein import into mitochondrial outer membrane|protein refolding|regulation of nitric-oxide synthase activity|response to unfolded protein|signal transduction	cytosol|melanosome|plasma membrane	ATP binding|ATPase activity|nitric-oxide synthase regulator activity|protein homodimerization activity|TPR domain binding|unfolded protein binding			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(6)|large_intestine(3)|liver(1)|lung(10)|ovary(2)|prostate(1)	28					Rifabutin(DB00615)	GTTACTTTCTCAGCAACCAAA	0.478000													44	20					2.77807e-22	3.04554e-22	1	1	0
MEDAG	84935	broad.mit.edu	37	13	31495943	31495943	+	Missense_Mutation	SNP	G	G	C			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr13:31495943G>C	ENST00000380482.4	+	4	1072	c.747G>C	c.(745-747)agG>agC	p.R249S	TEX26-AS1_ENST00000590344.1_RNA|TEX26-AS1_ENST00000586464.1_RNA|TEX26-AS1_ENST00000588726.1_RNA|TEX26-AS1_ENST00000592950.1_RNA|TEX26-AS1_ENST00000590721.1_RNA|TEX26-AS1_ENST00000593246.1_RNA|TEX26-AS1_ENST00000585870.1_RNA|TEX26-AS1_ENST00000586973.1_RNA|TEX26-AS1_ENST00000451495.2_RNA	NM_032849.3	NP_116238			mesenteric estrogen-dependent adipogenesis																		TAATCCGAAGGAGCAGTTTCT	0.353000													23	17					0	0	1	0	0
EGF	1950	broad.mit.edu	37	4	110932610	110932610	+	Nonstop_Mutation	SNP	G	G	T			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr4:110932610G>T	ENST00000265171.5	+	24	4068	c.3623G>T	c.(3622-3624)tGa>tTa	p.*1208L	EGF_ENST00000509793.1_Nonstop_Mutation_p.*1166L|EGF_ENST00000503392.1_Nonstop_Mutation_p.*1167L	NM_001178130.1|NM_001963.4	NP_001171601.1|NP_001954.2	P01133	EGF_HUMAN	epidermal growth factor	0					angiogenesis|DNA replication|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of secretion|platelet activation|platelet degranulation|positive regulation of catenin import into nucleus|positive regulation of epidermal growth factor receptor activity|positive regulation of MAP kinase activity|positive regulation of mitosis|regulation of calcium ion import|regulation of protein localization at cell surface	integral to membrane|plasma membrane|platelet alpha granule lumen	calcium ion binding|epidermal growth factor receptor binding|growth factor activity|transmembrane receptor protein tyrosine kinase activator activity			breast(1)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(19)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|soft_tissue(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	50		Hepatocellular(203;0.0893)		OV - Ovarian serous cystadenocarcinoma(123;9.87e-06)	Sulindac(DB00605)	CTGACTCAGTGAAAACTGGAA	0.438000													34	63					9.80977e-26	1.07778e-25	1	1	0
ZNF28	7576	broad.mit.edu	37	19	53304815	53304815	+	Missense_Mutation	SNP	G	G	A			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr19:53304815G>A	ENST00000438150.2	-	2	1017	c.124C>T	c.(124-126)Cat>Tat	p.H42Y	ZNF28_ENST00000360272.4_Missense_Mutation_p.H42Y|ZNF28_ENST00000594602.1_3'UTR|ZNF28_ENST00000414252.2_Missense_Mutation_p.H42Y|ZNF28_ENST00000339844.6_3'UTR|ZNF28_ENST00000457749.2_Missense_Mutation_p.H95Y			P17035	ZNF28_HUMAN	zinc finger protein 28	95	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(11)|liver(1)|lung(10)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	34				GBM - Glioblastoma multiforme(134;0.0386)|Lung(386;0.145)		TGGAAGCCATGAATGTCTTTC	0.428000													40	144					0	0	1	0	0
ZNF212	7988	broad.mit.edu	37	7	148947564	148947564	+	Silent	SNP	C	C	T	rs138413836	byFrequency	TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr7:148947564C>T	ENST00000335870.2	+	2	467	c.339C>T	c.(337-339)aaC>aaT	p.N113N		NM_012256.3	NP_036388.2	Q9UDV6	ZN212_HUMAN	zinc finger protein 212	113					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|identical protein binding|zinc ion binding			endometrium(2)|kidney(1)|large_intestine(4)|ovary(1)|prostate(1)	9	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00171)			GGCTGGAGAACGTGGAGAACC	0.617000													69	162					0	0	1	0	0
ALPK1	80216	broad.mit.edu	37	4	113353731	113353731	+	Missense_Mutation	SNP	G	G	T			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr4:113353731G>T	ENST00000458497.1	+	11	3307	c.3028G>T	c.(3028-3030)Gca>Tca	p.A1010S	ALPK1_ENST00000504176.2_Missense_Mutation_p.A932S|ALPK1_ENST00000177648.9_Missense_Mutation_p.A1010S	NM_001102406.1|NM_025144.3	NP_001095876.1|NP_079420.3	Q96QP1	ALPK1_HUMAN	alpha-kinase 1	1010							ATP binding|protein serine/threonine kinase activity			NS(1)|breast(1)|cervix(1)|endometrium(8)|kidney(2)|large_intestine(11)|lung(20)|ovary(6)|prostate(2)|urinary_tract(1)	53		Ovarian(17;0.0446)|Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.00325)		ACTCCACCGAGCACATAGTAA	0.463000													38	13					7.63091e-17	8.25721e-17	1	1	0
LRP2	4036	broad.mit.edu	37	2	170063152	170063152	+	Missense_Mutation	SNP	G	G	C			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr2:170063152G>C	ENST00000263816.3	-	39	7363	c.7078C>G	c.(7078-7080)Ctg>Gtg	p.L2360V		NM_004525.2	NP_004516.2	P98164	LRP2_HUMAN	low density lipoprotein receptor-related protein 2	2360	EGF-like 9.				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			biliary_tract(1)|breast(16)|central_nervous_system(6)|cervix(2)|endometrium(24)|haematopoietic_and_lymphoid_tissue(2)|kidney(17)|large_intestine(70)|liver(1)|lung(117)|ovary(19)|pancreas(1)|prostate(2)|skin(17)|upper_aerodigestive_tract(7)|urinary_tract(13)	315				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	AATCCAGGCAGAGCAAAGCAG	0.493000													9	39					0	0	1	0	0
UBN2	254048	broad.mit.edu	37	7	138968605	138968605	+	Missense_Mutation	SNP	C	C	A			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr7:138968605C>A	ENST00000473989.3	+	15	2954	c.2954C>A	c.(2953-2955)tCt>tAt	p.S985Y	UBN2_ENST00000288561.8_Missense_Mutation_p.S902Y	NM_173569.3	NP_775840.3	Q6ZU65	UBN2_HUMAN	ubinuclein 2		Ser-rich.									NS(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(5)|large_intestine(7)|lung(16)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(1)	42						CTTCCCTTATCTACCCCCTCA	0.483000													18	45					1.33834e-09	1.40863e-09	1	1	0
HMP19	51617	broad.mit.edu	37	5	173491291	173491291	+	Missense_Mutation	SNP	C	C	G	rs139341537		TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr5:173491291C>G	ENST00000303177.3	+	3	448	c.186C>G	c.(184-186)ttC>ttG	p.F62L	NSG2_ENST00000521959.1_3'UTR|NSG2_ENST00000521585.1_Missense_Mutation_p.F62L	NM_015980.4	NP_057064.1																					AAGGGAAGTTCCGGGTGCCGA	0.473000													34	27					0	0	1	0	0
TGM3	7053	broad.mit.edu	37	20	2297889	2297889	+	Missense_Mutation	SNP	C	C	T			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr20:2297889C>T	ENST00000381458.5	+	6	908	c.845C>T	c.(844-846)aCa>aTa	p.T282I	TGM3_ENST00000463090.1_3'UTR	NM_003245.3	NP_003236.3	Q08188	TGM3_HUMAN	transglutaminase 3	282					cell envelope organization|hair follicle morphogenesis|keratinization|peptide cross-linking|protein tetramerization	cytoplasm|extrinsic to internal side of plasma membrane	acyltransferase activity|calcium ion binding|GDP binding|GTP binding|GTPase activity|magnesium ion binding|protein-glutamine gamma-glutamyltransferase activity			breast(3)|cervix(1)|endometrium(1)|kidney(4)|large_intestine(11)|lung(10)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(2)	39					L-Glutamine(DB00130)	ACCCTCAACACAGGTACCTTG	0.577000													22	96					0	0	1	0	0
CACHD1	57685	broad.mit.edu	37	1	65130323	65130323	+	Missense_Mutation	SNP	C	C	A	rs145700540		TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr1:65130323C>A	ENST00000371073.2	+	15	2237	c.2237C>A	c.(2236-2238)tCc>tAc	p.S746Y	CACHD1_ENST00000495994.1_3'UTR|CACHD1_ENST00000290039.5_Missense_Mutation_p.S695Y			Q5VU97	CAHD1_HUMAN	cache domain containing 1	746					calcium ion transport	integral to membrane				breast(4)|endometrium(3)|kidney(3)|large_intestine(20)|lung(14)|ovary(2)|pancreas(1)|prostate(5)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	55						TATCCTGGTTCCCTCATGGAC	0.458000													37	76					2.66277e-13	2.85052e-13	1	1	0
SEC24C	9632	broad.mit.edu	37	10	75528902	75528902	+	Missense_Mutation	SNP	C	C	G			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr10:75528902C>G	ENST00000339365.2	+	18	2578	c.2416C>G	c.(2416-2418)Ctc>Gtc	p.L806V	SEC24C_ENST00000345254.4_Missense_Mutation_p.L806V|SEC24C_ENST00000411652.2_Missense_Mutation_p.L687V|SEC24C_ENST00000535742.1_Missense_Mutation_p.L54V|SEC24C_ENST00000540668.1_Missense_Mutation_p.L54V|SEC24C_ENST00000496827.1_3'UTR	NM_004922.3	NP_004913.2	P53992	SC24C_HUMAN	SEC24 family member C	806					COPII vesicle coating|intracellular protein transport|post-translational protein modification|protein N-linked glycosylation via asparagine	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|Golgi membrane|perinuclear region of cytoplasm	protein binding|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(3)|lung(12)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	32	Prostate(51;0.0112)					GAGCGGAGCTCTCCTGCAGGT	0.552000													4	15					0	0	1	0	0
AXDND1	126859	broad.mit.edu	37	1	179401446	179401446	+	Missense_Mutation	SNP	C	C	T			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr1:179401446C>T	ENST00000367618.3	+	15	1919	c.1532C>T	c.(1531-1533)tCa>tTa	p.S511L	AXDND1_ENST00000461179.2_3'UTR|AXDND1_ENST00000457238.2_Missense_Mutation_p.S511L	NM_144696.4	NP_653297.3	Q5T1B0	AXDN1_HUMAN	axonemal dynein light chain domain containing 1	511										NS(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(27)|ovary(1)|pancreas(1)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)	59						ATATTTAATTCAGTTCTTTTA	0.323000													3	2					0	0	1	0	0
HOXD13	3239	broad.mit.edu	37	2	176958222	176958222	+	Missense_Mutation	SNP	C	C	T			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr2:176958222C>T	ENST00000392539.3	+	1	604	c.604C>T	c.(604-606)Cac>Tac	p.H202Y		NM_000523.3	NP_000514.2	P35453	HXD13_HUMAN	homeobox D13	202					skeletal system development|transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|lung(3)	6			OV - Ovarian serous cystadenocarcinoma(117;0.0207)|Epithelial(96;0.18)	Colorectal(32;0.0526)|READ - Rectum adenocarcinoma(9;0.0678)		CCCTTACCAGCACGTGCCCGG	0.642000			T	NUP98	AML*								15	53					0	0	1	0	0
LDLR	3949	broad.mit.edu	37	19	11216117	11216117	+	Missense_Mutation	SNP	G	G	C			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr19:11216117G>C	ENST00000558518.1	+	4	722	c.535G>C	c.(535-537)Gag>Cag	p.E179Q	LDLR_ENST00000557933.1_Missense_Mutation_p.E179Q|LDLR_ENST00000545707.1_Intron|LDLR_ENST00000558013.1_Missense_Mutation_p.E179Q|LDLR_ENST00000455727.2_Intron|LDLR_ENST00000535915.1_Missense_Mutation_p.E138Q	NM_000527.4|NM_001195798.1	NP_000518.1|NP_001182727.1	P01130	LDLR_HUMAN	low density lipoprotein receptor	179	LDL-receptor class A 4.				cholesterol homeostasis|cholesterol metabolic process|interspecies interaction between organisms|intestinal cholesterol absorption|low-density lipoprotein particle clearance|receptor-mediated endocytosis	clathrin-coated endocytic vesicle membrane|coated pit|early endosome|endosome membrane|external side of plasma membrane|integral to plasma membrane|low-density lipoprotein particle|lysosome	calcium ion binding|low-density lipoprotein receptor activity|protein binding|very-low-density lipoprotein particle receptor activity	p.?(1)		breast(2)|endometrium(2)|large_intestine(5)|lung(8)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	26		Lung NSC(9;0.000245)|Renal(1328;0.0007)|Hepatocellular(1079;0.0524)		GBM - Glioblastoma multiforme(1328;1.36e-05)|STAD - Stomach adenocarcinoma(1328;0.000766)|Lung(535;0.197)	Methyl aminolevulinate(DB00992)|Porfimer(DB00707)	TGGCTCGGATGAGTGGCCGCA	0.632000													51	34					0	0	1	0	0
ZNF615	284370	broad.mit.edu	37	19	52496424	52496424	+	Silent	SNP	C	C	T			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr19:52496424C>T	ENST00000602063.1	-	6	2254	c.1905G>A	c.(1903-1905)aaG>aaA	p.K635K	ZNF615_ENST00000391795.3_Silent_p.K640K|ZNF615_ENST00000594083.1_Silent_p.K646K|ZNF615_ENST00000376716.5_Silent_p.K635K|ZNF615_ENST00000598071.1_Silent_p.K646K			Q8N8J6	ZN615_HUMAN	zinc finger protein 615	635					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(12)|ovary(5)|prostate(1)|skin(1)|stomach(3)|upper_aerodigestive_tract(2)	42		all_neural(266;0.117)		GBM - Glioblastoma multiforme(134;0.00142)|OV - Ovarian serous cystadenocarcinoma(262;0.019)		GGCATGTCTTCTTCCTGAAGG	0.388000													62	61					0	0	1	0	0
ANK3	288	broad.mit.edu	37	10	61830047	61830047	+	Missense_Mutation	SNP	G	G	A			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr10:61830047G>A	ENST00000280772.2	-	37	10783	c.10592C>T	c.(10591-10593)cCt>cTt	p.P3531L	ANK3_ENST00000503366.1_Intron|ANK3_ENST00000373827.2_Intron|ANK3_ENST00000355288.2_Intron	NM_020987.3	NP_066267.2	Q12955	ANK3_HUMAN	ankyrin 3, node of Ranvier (ankyrin G)						establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						TGTTTTAAAAGGAGTGGCAAA	0.418000													19	68					0	0	1	0	0
HDHD1	8226	broad.mit.edu	37	X	6995398	6995398	+	Missense_Mutation	SNP	T	T	C			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chrX:6995398T>C	ENST00000381077.5	-	3	449	c.373A>G	c.(373-375)Agc>Ggc	p.S125G	HDHD1_ENST00000412827.2_Missense_Mutation_p.S82G|HDHD1_ENST00000424830.2_Missense_Mutation_p.S148G|HDHD1_ENST00000540122.1_Missense_Mutation_p.S125G	NM_001178136.1|NM_012080.4	NP_001171607.1|NP_036212.3	Q08623	HDHD1_HUMAN	haloacid dehalogenase-like hydrolase domain containing 1	125					nucleotide metabolic process		metal ion binding|phosphatase activity			breast(2)|large_intestine(1)|lung(3)	6						TTGTGGCGGCTTGTCTTCATA	0.577000													34	4					0	0	1	0	0
LIMA1	51474	broad.mit.edu	37	12	50575725	50575725	+	Silent	SNP	G	G	A			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr12:50575725G>A	ENST00000547825.1	-	4	1599	c.330C>T	c.(328-330)atC>atT	p.I110I	LIMA1_ENST00000552823.1_Silent_p.I252I|LIMA1_ENST00000552491.1_Silent_p.I109I|LIMA1_ENST00000552783.1_Silent_p.I253I|LIMA1_ENST00000394943.3_Silent_p.I413I|LIMA1_ENST00000552909.1_Silent_p.I251I|LIMA1_ENST00000341247.4_Silent_p.I412I	NM_001243775.1	NP_001230704.1	Q9UHB6	LIMA1_HUMAN	LIM domain and actin binding 1	412					actin filament bundle assembly|negative regulation of actin filament depolymerization|ruffle organization	cytoplasm|focal adhesion|stress fiber	actin filament binding|actin monomer binding|zinc ion binding			NS(1)|breast(4)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(17)|ovary(1)|prostate(2)|skin(2)	44						GGAAGCAGCTGATGTGAAACA	0.488000													22	42					0	0	1	0	0
PKP4	8502	broad.mit.edu	37	2	159481497	159481497	+	Silent	SNP	G	G	A	rs144359585		TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr2:159481497G>A	ENST00000389757.3	+	7	836	c.711G>A	c.(709-711)ctG>ctA	p.L237L	PKP4_ENST00000389759.3_Silent_p.L237L	NM_001005476.1	NP_001005476.1	Q99569	PKP4_HUMAN	plakophilin 4	237					cell adhesion	desmosome	protein binding			breast(2)|central_nervous_system(1)|endometrium(7)|kidney(3)|large_intestine(9)|lung(21)|ovary(6)|skin(5)|upper_aerodigestive_tract(6)|urinary_tract(1)	61						GGGGGTCTCTGAGAACTTCTC	0.532000										HNSCC(62;0.18)			18	46					0	0	1	0	0
DLG2	1740	broad.mit.edu	37	11	83544746	83544746	+	Missense_Mutation	SNP	C	C	G			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr11:83544746C>G	ENST00000398309.2	-	12	1788	c.1318G>C	c.(1318-1320)Gat>Cat	p.D440H	DLG2_ENST00000531015.1_Missense_Mutation_p.D407H|DLG2_ENST00000532653.1_Missense_Mutation_p.D440H|DLG2_ENST00000376104.2_Missense_Mutation_p.D545H|DLG2_ENST00000524982.1_Missense_Mutation_p.D440H|DLG2_ENST00000376106.3_5'UTR|DLG2_ENST00000543673.1_Missense_Mutation_p.D545H|DLG2_ENST00000418306.2_Missense_Mutation_p.D337H|DLG2_ENST00000330014.6_Missense_Mutation_p.D379H|DLG2_ENST00000537455.1_Missense_Mutation_p.D194H|DLG2_ENST00000398301.2_Missense_Mutation_p.D479H|DLG2_ENST00000280241.8_Missense_Mutation_p.D479H	NM_001364.3	NP_001355.2	Q15700	DLG2_HUMAN	discs, large homolog 2 (Drosophila)	440	PDZ 3.					cell junction|postsynaptic density|postsynaptic membrane	guanylate kinase activity|protein binding			breast(1)|central_nervous_system(1)|endometrium(8)|kidney(3)|large_intestine(11)|lung(35)|ovary(3)|pancreas(2)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	71		all_cancers(6;0.00791)|Acute lymphoblastic leukemia(157;4.44e-05)|all_hematologic(158;0.0036)				CCTTCTCCATCTTCCCCACCG	0.522000													13	57					0	0	1	0	0
TRIML2	205860	broad.mit.edu	37	4	189026044	189026044	+	Missense_Mutation	SNP	C	C	G			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr4:189026044C>G	ENST00000512729.1	-	2	456	c.82G>C	c.(82-84)Gaa>Caa	p.E28Q	TRIML2_ENST00000536972.1_Missense_Mutation_p.E78Q|TRIML2_ENST00000326754.3_Missense_Mutation_p.E28Q	NM_173553.1	NP_775824.1	Q8N7C3	TRIMM_HUMAN	tripartite motif family-like 2	28							ligase activity	p.E28*(1)		central_nervous_system(2)|kidney(1)|large_intestine(7)|lung(25)|prostate(3)|urinary_tract(1)	39		all_cancers(14;3.11e-44)|all_epithelial(14;7.86e-31)|all_lung(41;4.3e-13)|Lung NSC(41;9.69e-13)|Melanoma(20;7.86e-05)|Breast(6;0.000148)|all_hematologic(60;0.0202)|Hepatocellular(41;0.0218)|Renal(120;0.0376)|Prostate(90;0.0513)		OV - Ovarian serous cystadenocarcinoma(60;1.79e-11)|BRCA - Breast invasive adenocarcinoma(30;4.52e-06)|GBM - Glioblastoma multiforme(59;1.62e-05)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.0091)|READ - Rectum adenocarcinoma(43;0.163)		TTAGCTGCTTCAAGTTTCTCC	0.393000													37	20					0	0	1	0	0
GAS2L1	10634	broad.mit.edu	37	22	29707996	29707996	+	Missense_Mutation	SNP	G	G	A			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr22:29707996G>A	ENST00000471961.1	+	5	2603	c.1555G>A	c.(1555-1557)Ggc>Agc	p.G519S	GAS2L1_ENST00000406549.3_Intron|GAS2L1_ENST00000407647.2_Missense_Mutation_p.G519S|GAS2L1_ENST00000341313.6_3'UTR|GAS2L1_ENST00000360113.2_3'UTR|GAS2L1_ENST00000403764.1_Missense_Mutation_p.G519S|GAS2L1_ENST00000407854.1_Missense_Mutation_p.G519S			Q99501	GA2L1_HUMAN	growth arrest-specific 2 like 1	365					cell cycle arrest	cytoplasm|cytoskeleton				endometrium(2)|lung(2)|prostate(1)	5						CAGCTGTTCCGGCGCCTGGAA	0.692000													40	70					0	0	1	0	0
CEP350	9857	broad.mit.edu	37	1	179966062	179966062	+	Missense_Mutation	SNP	C	C	T			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr1:179966062C>T	ENST00000367607.3	+	6	1188	c.770C>T	c.(769-771)tCt>tTt	p.S257F		NM_014810.4	NP_055625.4	Q5VT06	CE350_HUMAN	centrosomal protein 350kDa	257						centrosome|nucleus|spindle				central_nervous_system(1)|endometrium(9)|kidney(4)|large_intestine(7)|lung(35)|ovary(4)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	66						CTAACTGACTCTTCTCCATCC	0.378000													15	44					0	0	1	0	0
MTO1	25821	broad.mit.edu	37	6	74191780	74191780	+	Silent	SNP	C	C	T			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr6:74191780C>T	ENST00000498286.1	+	8	1555	c.1278C>T	c.(1276-1278)atC>atT	p.I426I	MTO1_ENST00000370300.4_Silent_p.I451I|MTO1_ENST00000415954.2_Silent_p.I466I|MTO1_ENST00000370305.1_Silent_p.I377I			Q9Y2Z2	MTO1_HUMAN	mitochondrial tRNA translation optimization 1	451					tRNA processing	mitochondrion	flavin adenine dinucleotide binding	p.I451I(1)		breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(8)|ovary(3)|pancreas(1)|prostate(3)|skin(4)|stomach(1)	27						TAGCCGGAATCAACGCCAGTC	0.463000													5	83					0	0	1	0	0
DNAJA1	3301	broad.mit.edu	37	9	33034305	33034305	+	Silent	SNP	G	G	A			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr9:33034305G>A	ENST00000330899.4	+	6	918	c.735G>A	c.(733-735)caG>caA	p.Q245Q	DNAJA1_ENST00000495015.1_3'UTR|DNAJA1_ENST00000544625.1_Silent_p.Q88Q	NM_001539.2	NP_001530.1	P31689	DNJA1_HUMAN	DnaJ (Hsp40) homolog, subfamily A, member 1	245					protein folding|response to heat|response to unfolded protein	membrane	ATP binding|heat shock protein binding|low-density lipoprotein particle receptor binding|metal ion binding|unfolded protein binding			large_intestine(2)|ovary(1)|skin(3)	6			LUSC - Lung squamous cell carcinoma(29;0.0227)	GBM - Glioblastoma multiforme(74;0.102)		TGTTAGATCAGAAGGACCATG	0.368000													24	7					0	0	1	0	0
FAM189B	10712	broad.mit.edu	37	1	155220937	155220937	+	Missense_Mutation	SNP	G	G	C			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr1:155220937G>C	ENST00000361361.2	-	8	1422	c.913C>G	c.(913-915)Cag>Gag	p.Q305E	FAM189B_ENST00000368368.3_Missense_Mutation_p.Q287E|FAM189B_ENST00000350210.2_Missense_Mutation_p.Q209E|FAM189B_ENST00000472550.1_5'UTR	NM_006589.2	NP_006580.2	P81408	F189B_HUMAN	family with sequence similarity 189, member B	305						integral to membrane	WW domain binding			breast(4)|central_nervous_system(1)|endometrium(3)|large_intestine(4)|lung(6)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	23						TCGTGAAGCTGAGGGTCAAAG	0.567000											OREG0013858	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	8	11					0	0	1	0	0
DEPDC1	55635	broad.mit.edu	37	1	68954598	68954598	+	Splice_Site	SNP	C	C	G			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr1:68954598C>G	ENST00000456315.2	-	4	705		c.e4+1		DEPDC1_ENST00000370966.5_Splice_Site	NM_001114120.1	NP_001107592.1	Q5TB30	DEP1A_HUMAN	DEP domain containing 1						intracellular signal transduction|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	transcriptional repressor complex	GTPase activator activity|protein binding			endometrium(1)|kidney(1)|large_intestine(3)|lung(4)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	13				OV - Ovarian serous cystadenocarcinoma(397;7.21e-36)		TTTTATCTTACTAGATCAGAA	0.284000													12	17					0	0	1	0	0
KMT2A	4297	broad.mit.edu	37	11	118344537	118344537	+	Missense_Mutation	SNP	C	C	T			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr11:118344537C>T	ENST00000534358.1	+	3	2686	c.2663C>T	c.(2662-2664)tCa>tTa	p.S888L	KMT2A_ENST00000389506.5_Missense_Mutation_p.S888L|KMT2A_ENST00000354520.4_Missense_Mutation_p.S888L	NM_001197104.1|NM_005933.3	NP_001184033.1|NP_005924.2			lysine (K)-specific methyltransferase 2A																		aagcgggagtcaaggaaagag	0.468000													23	15					0	0	1	0	0
LHX9	56956	broad.mit.edu	37	1	197898167	197898167	+	Silent	SNP	G	G	A			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr1:197898167G>A	ENST00000367390.3	+	6	972	c.945G>A	c.(943-945)agG>agA	p.R315R	LHX9_ENST00000561173.1_Intron|LHX9_ENST00000367391.1_Intron|LHX9_ENST00000337020.2_Intron|LHX9_ENST00000367387.4_Silent_p.R324R	NM_001014434.1	NP_001014434.1	Q9NQ69	LHX9_HUMAN	LIM homeobox 9	324					motor axon guidance|negative regulation of transcription, DNA-dependent	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			endometrium(8)|kidney(1)|large_intestine(6)|liver(2)|lung(14)|ovary(2)|skin(1)|stomach(1)	35						AATTCAGAAGGAACCTTTTGC	0.498000													14	50					0	0	1	0	0
PPP2CA	5515	broad.mit.edu	37	5	133537700	133537700	+	Missense_Mutation	SNP	C	C	T			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr5:133537700C>T	ENST00000481195.1	-	3	605	c.325G>A	c.(325-327)Gaa>Aaa	p.E109K	CTD-2410N18.5_ENST00000519718.1_Intron	NM_002715.2	NP_002706.1			protein phosphatase 2, catalytic subunit, alpha isozyme											endometrium(2)|kidney(1)|large_intestine(2)|lung(4)|ovary(2)|skin(1)	12			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			GTGATGCGTTCACGGTAACGA	0.323000													12	21					0	0	1	0	0
TCP10L2	401285	broad.mit.edu	37	6	167591999	167591999	+	Missense_Mutation	SNP	C	C	T			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr6:167591999C>T	ENST00000366832.2	+	5	757	c.626C>T	c.(625-627)gCa>gTa	p.A209V		NM_001145121.1	NP_001138593.1	B9ZVM9	B9ZVM9_HUMAN	t-complex 10-like 2	209										endometrium(1)|kidney(2)|lung(3)	6						ACTCCCGGTGCAGAAAGACGG	0.532000													16	103					0	0	1	0	0
LPAL2	80350	broad.mit.edu	37	6	160908384	160908384	+	RNA	SNP	C	C	T			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr6:160908384C>T	ENST00000335388.5	-	0	588					NR_028092.1															large_intestine(1)|lung(4)	5		Breast(66;0.000496)|Ovarian(120;0.0303)|Prostate(117;0.214)		OV - Ovarian serous cystadenocarcinoma(65;2.5e-17)|BRCA - Breast invasive adenocarcinoma(81;6.48e-06)		GCAGTACTCCCACCTGACTTT	0.493000													15	49					0	0	1	0	0
USP9Y	8287	broad.mit.edu	37	Y	14952195	14952195	+	Missense_Mutation	SNP	G	G	T			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chrY:14952195G>T	ENST00000338981.3	+	36	6688	c.5743G>T	c.(5743-5745)Gat>Tat	p.D1915Y	USP9Y_ENST00000426564.2_3'UTR	NM_004654.3	NP_004645.2	O00507	USP9Y_HUMAN	ubiquitin specific peptidase 9, Y-linked	1915					BMP signaling pathway|protein deubiquitination|spermatogenesis|transforming growth factor beta receptor signaling pathway|ubiquitin-dependent protein catabolic process	cytoplasm	co-SMAD binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			kidney(1)|large_intestine(8)|lung(5)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	17						AATGGATGATGATGAAGAAAT	0.363000													50	6					1.89013e-27	2.0858e-27	1	1	0
ZNF449	203523	broad.mit.edu	37	X	134494183	134494183	+	Missense_Mutation	SNP	C	C	T			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chrX:134494183C>T	ENST00000339249.4	+	5	879	c.739C>T	c.(739-741)Cca>Tca	p.P247S		NM_152695.5	NP_689908.3	Q6P9G9	ZN449_HUMAN	zinc finger protein 449	247					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(6)|ovary(2)|prostate(1)|skin(1)	23	Acute lymphoblastic leukemia(192;6.56e-05)					GACTATGTATCCATTTATTGT	0.368000													17	39					0	0	1	0	0
AP1G1	164	broad.mit.edu	37	16	71782178	71782178	+	Missense_Mutation	SNP	G	G	C			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr16:71782178G>C	ENST00000299980.4	-	16	2042	c.1601C>G	c.(1600-1602)tCc>tGc	p.S534C	AP1G1_ENST00000393512.3_Missense_Mutation_p.S537C|AP1G1_ENST00000433195.2_Missense_Mutation_p.S557C|AP1G1_ENST00000423132.2_Missense_Mutation_p.S537C|AP1G1_ENST00000569748.1_Missense_Mutation_p.S534C	NM_001128.5	NP_001119.3	O43747	AP1G1_HUMAN	adaptor-related protein complex 1, gamma 1 subunit	534					endocytosis|intracellular protein transport|post-Golgi vesicle-mediated transport|regulation of defense response to virus by virus|viral reproduction	clathrin adaptor complex|clathrin coated vesicle membrane|cytosol|Golgi membrane|lysosomal membrane|recycling endosome	kinesin binding|protein transporter activity			breast(1)|endometrium(8)|large_intestine(6)|lung(7)|ovary(4)|pancreas(1)|urinary_tract(1)	28		Ovarian(137;0.125)				GAATCGAGTGGAAAGCTTCAT	0.358000													6	29					0	0	1	0	0
ZNF292	23036	broad.mit.edu	37	6	87943114	87943114	+	Nonsense_Mutation	SNP	C	C	T			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr6:87943114C>T	ENST00000369577.3	+	5	653	c.610C>T	c.(610-612)Cag>Tag	p.Q204*	ZNF292_ENST00000339907.4_Nonsense_Mutation_p.Q199*	NM_015021.1	NP_055836.1	O60281	ZN292_HUMAN	zinc finger protein 292	204					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.Q204*(1)|p.Q59*(1)		NS(1)|breast(4)|central_nervous_system(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(27)|lung(21)|ovary(4)|prostate(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	89		all_cancers(76;3.82e-09)|Prostate(29;1.34e-10)|Acute lymphoblastic leukemia(125;2.17e-10)|all_hematologic(105;1.08e-06)|all_epithelial(107;5.31e-05)		BRCA - Breast invasive adenocarcinoma(108;0.0199)		CAAAACAAATCAGTTAAGTCA	0.333000													27	25					0	0	1	0	0
ADAMTS13	11093	broad.mit.edu	37	9	136321320	136321320	+	Missense_Mutation	SNP	C	C	G			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr9:136321320C>G	ENST00000371929.3	+	26	4142	c.3698C>G	c.(3697-3699)tCt>tGt	p.S1233C	ADAMTS13_ENST00000371916.1_3'UTR|ADAMTS13_ENST00000356589.2_Missense_Mutation_p.S1146C|ADAMTS13_ENST00000485925.1_3'UTR|ADAMTS13_ENST00000371910.1_Missense_Mutation_p.S29C|ADAMTS13_ENST00000355699.2_Missense_Mutation_p.S1177C	NM_139025.3|NM_139027.3	NP_620594.1|NP_620596.2	Q76LX8	ATS13_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 13	1233	CUB 1.				cell-matrix adhesion|glycoprotein metabolic process|integrin-mediated signaling pathway|peptide catabolic process|platelet activation|protein processing|proteolysis	cell surface|proteinaceous extracellular matrix	calcium ion binding|integrin binding|metalloendopeptidase activity|zinc ion binding			central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(13)|ovary(2)|prostate(3)|skin(4)	36				OV - Ovarian serous cystadenocarcinoma(145;1.06e-07)|Epithelial(140;1.28e-06)|all cancers(34;1.46e-05)		CTTGAGAGTTCTCTCAACTGC	0.637000													15	35					0	0	1	0	0
NBPF1	55672	broad.mit.edu	37	1	16893787	16893787	+	Missense_Mutation	SNP	C	C	G			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr1:16893787C>G	ENST00000430580.2	-	25	3613	c.2726G>C	c.(2725-2727)aGa>aCa	p.R909T	NBPF1_ENST00000432949.1_3'UTR|NBPF1_ENST00000420031.2_3'UTR	NM_017940.3	NP_060410.2	Q3BBV0	NBPF1_HUMAN	neuroblastoma breakpoint family, member 1	909	NBPF 5.					cytoplasm									UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.52e-06)|COAD - Colon adenocarcinoma(227;1.05e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.179)		TGAATAACATCTATCCAGTGA	0.488000													51	1173					0	0	1	0	0
MOV10	4343	broad.mit.edu	37	1	113241400	113241400	+	Missense_Mutation	SNP	A	A	G			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr1:113241400A>G	ENST00000369644.1	+	18	3433	c.2404A>G	c.(2404-2406)Aag>Gag	p.K802E	MOV10_ENST00000413052.2_Missense_Mutation_p.K858E|MOV10_ENST00000357443.2_Missense_Mutation_p.K858E|MOV10_ENST00000468624.1_3'UTR|MOV10_ENST00000369645.1_Missense_Mutation_p.K858E			Q9HCE1	MOV10_HUMAN	Mov10, Moloney leukemia virus 10, homolog (mouse)	858					mRNA cleavage involved in gene silencing by miRNA|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body	ATP binding|helicase activity|protein binding|RNA binding			breast(1)|cervix(1)|endometrium(3)|large_intestine(6)|lung(15)|ovary(5)|prostate(1)|skin(3)|urinary_tract(3)	38	Lung SC(450;0.246)	all_cancers(81;3.31e-11)|all_epithelial(167;5.69e-10)|all_lung(203;3.73e-05)|Breast(1374;0.000525)|Lung NSC(69;0.000954)|Ovarian(761;0.0367)|Lung SC(238;0.114)		OV - Ovarian serous cystadenocarcinoma(397;3.99e-67)|all cancers(265;1e-62)|Epithelial(280;4.78e-61)|Lung(183;0.0234)|Colorectal(144;0.0686)|READ - Rectum adenocarcinoma(129;0.0929)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)|BRCA - Breast invasive adenocarcinoma(282;0.24)		GGATGACATCAAGGACTTGAA	0.552000													41	88					0	0	1	0	0
PYHIN1	149628	broad.mit.edu	37	1	158908324	158908324	+	Missense_Mutation	SNP	G	G	C			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr1:158908324G>C	ENST00000368140.1	+	3	648	c.403G>C	c.(403-405)Gga>Cga	p.G135R	PYHIN1_ENST00000368135.4_Missense_Mutation_p.G135R|PYHIN1_ENST00000368138.3_Missense_Mutation_p.G126R|PYHIN1_ENST00000392252.3_Missense_Mutation_p.G126R|PYHIN1_ENST00000392254.2_Missense_Mutation_p.G135R	NM_152501.4|NM_198928.4|NM_198929.4	NP_689714.2|NP_945146.1|NP_945147.1	Q6K0P9	IFIX_HUMAN	pyrin and HIN domain family, member 1	135					cell cycle	nuclear speck				breast(2)|endometrium(3)|large_intestine(10)|lung(32)|ovary(3)|pancreas(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	60	all_hematologic(112;0.0378)					GGAGACTCTTGGACCTCAGGT	0.498000													36	16					0	0	1	0	0
TUBGCP2	10844	broad.mit.edu	37	10	135093396	135093396	+	Silent	SNP	G	G	A			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr10:135093396G>A	ENST00000368563.2	-	18	2939	c.2583C>T	c.(2581-2583)ttC>ttT	p.F861F	TUBGCP2_ENST00000543663.1_Silent_p.F889F|TUBGCP2_ENST00000252936.3_Silent_p.F861F|TUBGCP2_ENST00000417178.2_Silent_p.F731F|TUBGCP2_ENST00000368562.1_Silent_p.F454F	NM_001256617.1|NM_006659.3	NP_001243546.1|NP_006650.1	Q9BSJ2	GCP2_HUMAN	tubulin, gamma complex associated protein 2	861					G2/M transition of mitotic cell cycle|microtubule nucleation|protein complex assembly	centrosome|cytoplasmic microtubule|cytosol|spindle pole	protein binding			breast(2)|cervix(1)|endometrium(1)|kidney(3)|large_intestine(6)|lung(16)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)	35		all_cancers(35;1.14e-09)|all_epithelial(44;5.79e-08)|Lung NSC(174;0.00263)|all_lung(145;0.0039)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.172)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;8.87e-06)|all cancers(32;8.98e-06)|Epithelial(32;1.15e-05)		AGAAACCATTGAAGTCAAGCC	0.657000													14	5					0	0	1	0	0
PUS3	83480	broad.mit.edu	37	11	125765330	125765330	+	Nonsense_Mutation	SNP	G	G	A			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr11:125765330G>A	ENST00000227474.3	-	3	830	c.733C>T	c.(733-735)Caa>Taa	p.Q245*	HYLS1_ENST00000425380.2_Intron|HYLS1_ENST00000526028.1_Intron|HYLS1_ENST00000356438.3_Intron|PUS3_ENST00000530811.1_Nonsense_Mutation_p.Q245*	NM_001271985.1|NM_031307.3	NP_001258914.1|NP_112597	Q9BZE2	PUS3_HUMAN	pseudouridylate synthase 3	245						nucleus	RNA binding			NS(1)|large_intestine(3)|lung(4)|ovary(1)|prostate(1)	10	all_hematologic(175;0.177)	Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.131)|all_lung(97;0.139)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.1e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.043)		AGCTGTACTTGAGCAGATAGA	0.458000													18	51					0	0	1	0	0
RNF111	54778	broad.mit.edu	37	15	59323899	59323899	+	Nonsense_Mutation	SNP	C	C	G			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr15:59323899C>G	ENST00000348370.4	+	2	1311	c.878C>G	c.(877-879)tCa>tGa	p.S293*	RNF111_ENST00000557998.1_Nonsense_Mutation_p.S293*|RNF111_ENST00000561186.1_Nonsense_Mutation_p.S293*|RNF111_ENST00000434298.1_Nonsense_Mutation_p.S293*|RNF111_ENST00000559209.1_Nonsense_Mutation_p.S293*	NM_001270528.1|NM_001270529.1|NM_017610.7	NP_001257457.1|NP_001257458.1|NP_060080.6	Q6ZNA4	RN111_HUMAN	ring finger protein 111	293	Interaction with AXIN1.|Ser-rich.				multicellular organismal development|positive regulation of transcription, DNA-dependent	cytoplasm|nucleus	protein binding|ubiquitin-protein ligase activity|zinc ion binding			breast(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(9)|lung(11)|ovary(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	35				all cancers(107;0.194)		GCTGTTCCCTCAGGTAAAAAT	0.368000													25	50					0	0	1	0	0
KIF15	56992	broad.mit.edu	37	3	44867897	44867897	+	Missense_Mutation	SNP	G	G	C			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr3:44867897G>C	ENST00000326047.4	+	22	2880	c.2731G>C	c.(2731-2733)Gaa>Caa	p.E911Q	KIF15_ENST00000425755.1_Missense_Mutation_p.E546Q	NM_020242.2	NP_064627.1	Q9NS87	KIF15_HUMAN	kinesin family member 15	911					blood coagulation|cell proliferation|microtubule-based movement|mitosis	centrosome|cytosol|microtubule|plus-end kinesin complex|spindle	ATP binding|DNA binding|microtubule motor activity			breast(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(7)|liver(2)|lung(9)|ovary(1)|prostate(4)|urinary_tract(5)	36				BRCA - Breast invasive adenocarcinoma(193;0.0099)|KIRC - Kidney renal clear cell carcinoma(197;0.0564)|Kidney(197;0.0707)		GGCAGAAAAAGAACGCAATAA	0.303000													13	22					0	0	1	0	0
FAM57B	83723	broad.mit.edu	37	16	30038107	30038107	+	Silent	SNP	G	G	A			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr16:30038107G>A	ENST00000380495.4	-	3	998	c.267C>T	c.(265-267)atC>atT	p.I89I	FAM57B_ENST00000279389.4_Silent_p.I39I|FAM57B_ENST00000564806.1_Silent_p.I39I	NM_031478.4	NP_113666.2	Q71RH2	FA57B_HUMAN	family with sequence similarity 57, member B	89	TLC.					endoplasmic reticulum|integral to membrane				central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(4)|lung(5)|upper_aerodigestive_tract(1)	14						ACATGGCGTAGATGTCGTAGA	0.617000													9	44					0	0	1	0	0
CDK19	23097	broad.mit.edu	37	6	110988759	110988759	+	Missense_Mutation	SNP	G	G	A			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr6:110988759G>A	ENST00000368911.3	-	4	513	c.334C>T	c.(334-336)Cgt>Tgt	p.R112C	CDK19_ENST00000323817.3_Missense_Mutation_p.R52C	NM_015076.3	NP_055891.1	Q9BWU1	CDK19_HUMAN	cyclin-dependent kinase 19	112	Protein kinase.						ATP binding|cyclin-dependent protein kinase activity|protein binding	p.R112C(1)		breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(5)|lung(9)|ovary(2)|prostate(2)|skin(1)	22						TTTGATGCACGGTGAAACTTA	0.308000													12	49					0	0	1	0	0
QRSL1	55278	broad.mit.edu	37	6	107096958	107096958	+	Nonsense_Mutation	SNP	C	C	T			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr6:107096958C>T	ENST00000369046.4	+	5	543	c.439C>T	c.(439-441)Caa>Taa	p.Q147*	QRSL1_ENST00000369044.1_Nonsense_Mutation_p.Q147*	NM_018292.4	NP_060762.3	Q9H0R6	QRSL1_HUMAN	glutaminyl-tRNA synthase (glutamine-hydrolyzing)-like 1	147				Q -> R (in Ref. 1; CAB66614).	translation		ATP binding|carbon-nitrogen ligase activity, with glutamine as amido-N-donor			endometrium(2)|kidney(1)|large_intestine(4)|lung(4)	11	Breast(9;0.0107)|all_epithelial(6;0.14)	all_cancers(87;0.00768)|Acute lymphoblastic leukemia(125;2.27e-07)|all_hematologic(75;1.38e-05)|all_epithelial(87;0.248)	Epithelial(6;0.000334)|all cancers(7;0.00157)|BRCA - Breast invasive adenocarcinoma(8;0.00721)|OV - Ovarian serous cystadenocarcinoma(5;0.0152)	BRCA - Breast invasive adenocarcinoma(108;0.118)|all cancers(137;0.167)|Epithelial(106;0.176)		TTATTCAAAACAATATAGAGA	0.438000													17	29					0	0	1	0	0
ALPK1	80216	broad.mit.edu	37	4	113353729	113353729	+	Missense_Mutation	SNP	G	G	T	rs141398762		TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr4:113353729G>T	ENST00000458497.1	+	11	3305	c.3026G>T	c.(3025-3027)cGa>cTa	p.R1009L	ALPK1_ENST00000504176.2_Missense_Mutation_p.R931L|ALPK1_ENST00000177648.9_Missense_Mutation_p.R1009L	NM_001102406.1|NM_025144.3	NP_001095876.1|NP_079420.3	Q96QP1	ALPK1_HUMAN	alpha-kinase 1	1009							ATP binding|protein serine/threonine kinase activity			NS(1)|breast(1)|cervix(1)|endometrium(8)|kidney(2)|large_intestine(11)|lung(20)|ovary(6)|prostate(2)|urinary_tract(1)	53		Ovarian(17;0.0446)|Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.00325)		CAACTCCACCGAGCACATAGT	0.463000													40	12					2.24893e-16	2.42827e-16	1	1	0
NAA16	79612	broad.mit.edu	37	13	41941684	41941684	+	Missense_Mutation	SNP	G	G	A			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr13:41941684G>A	ENST00000379406.3	+	14	1973	c.1649G>A	c.(1648-1650)aGa>aAa	p.R550K	NAA16_ENST00000497143.1_3'UTR	NM_024561.4	NP_078837.3	Q6N069	NAA16_HUMAN	N(alpha)-acetyltransferase 16, NatA auxiliary subunit	550					N-terminal protein amino acid acetylation|positive regulation of transcription, DNA-dependent	cytoplasm|transcription factor complex	binding			breast(2)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(8)|prostate(1)|urinary_tract(2)	31						ATACTCAGAAGACATGCCTTT	0.358000													4	29					0	0	1	0	0
DDX60	55601	broad.mit.edu	37	4	169176889	169176889	+	Missense_Mutation	SNP	T	T	C			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr4:169176889T>C	ENST00000393743.3	-	26	3821	c.3530A>G	c.(3529-3531)aAa>aGa	p.K1177R	DDX60_ENST00000505393.1_5'UTR	NM_017631.5	NP_060101.3	Q8IY21	DDX60_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 60	1177							ATP binding|ATP-dependent helicase activity|RNA binding			breast(1)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(15)|liver(1)|lung(21)|ovary(1)|pancreas(2)|prostate(1)|skin(4)|urinary_tract(4)	63		Prostate(90;0.00876)|Renal(120;0.0183)|all_neural(102;0.0837)|Melanoma(52;0.132)		GBM - Glioblastoma multiforme(119;0.0485)		TATGGATTTTTTAACTTTTCG	0.358000													15	6					0	0	1	0	0
SLC8A2	6543	broad.mit.edu	37	19	47960819	47960819	+	Silent	SNP	G	G	A			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr19:47960819G>A	ENST00000236877.6	-	3	1103	c.708C>T	c.(706-708)ttC>ttT	p.F236F	SLC8A2_ENST00000542837.1_5'UTR|SLC8A2_ENST00000539381.1_Intron	NM_015063.2	NP_055878.1	Q9UPR5	NAC2_HUMAN	solute carrier family 8 (sodium/calcium exchanger), member 2	236					cell communication|platelet activation	integral to membrane|plasma membrane	calcium:sodium antiporter activity|calmodulin binding			breast(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(10)|ovary(2)|prostate(2)|skin(5)|stomach(1)	31		all_cancers(25;3.05e-07)|all_lung(116;4.19e-06)|Lung NSC(112;7.16e-06)|all_epithelial(76;7.65e-06)|all_neural(266;0.0652)|Ovarian(192;0.086)|Breast(70;0.173)		OV - Ovarian serous cystadenocarcinoma(262;0.000501)|all cancers(93;0.00058)|Epithelial(262;0.0181)|GBM - Glioblastoma multiforme(486;0.0457)		CGCACACCGGGAAGAAGACCA	0.677000													8	39					0	0	1	0	0
MAGED2	10916	broad.mit.edu	37	X	54838641	54838641	+	Missense_Mutation	SNP	C	C	G			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chrX:54838641C>G	ENST00000375068.1	+	7	1275	c.1042C>G	c.(1042-1044)Ctt>Gtt	p.L348V	MAGED2_ENST00000218439.4_Missense_Mutation_p.L348V|MAGED2_ENST00000375058.1_Missense_Mutation_p.L348V|MAGED2_ENST00000396224.1_Missense_Mutation_p.L348V|MAGED2_ENST00000375053.2_Missense_Mutation_p.L348V|MAGED2_ENST00000347546.4_Missense_Mutation_p.L330V|MAGED2_ENST00000375062.4_Missense_Mutation_p.L263V|MAGED2_ENST00000375060.1_Missense_Mutation_p.L263V			Q9UNF1	MAGD2_HUMAN	melanoma antigen family D, 2	348	MAGE.									breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(8)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	26						CTTGTACATTCTTCTCAGCAC	0.493000													10	6					0	0	1	0	0
KRT10	3858	broad.mit.edu	37	17	38975102	38975102	+	Missense_Mutation	SNP	G	G	C			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr17:38975102G>C	ENST00000269576.5	-	7	1694	c.1685C>G	c.(1684-1686)tCc>tGc	p.S562C		NM_000421.3	NP_000412	P13645	K1C10_HUMAN	keratin 10	562	Gly-rich.|Ser-rich.|Tail.				epidermis development		protein binding|structural constituent of epidermis			NS(2)|kidney(1)|large_intestine(3)|lung(4)|prostate(1)	11		Breast(137;0.000301)				GCCTCCGCTGGAgctgccgcc	0.677000													14	10					0	0	1	0	0
YY1AP1	55249	broad.mit.edu	37	1	155629567	155629567	+	Silent	SNP	G	G	A			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr1:155629567G>A	ENST00000368340.5	-	10	2596	c.2488C>T	c.(2488-2490)Ctg>Ttg	p.L830L	YY1AP1_ENST00000404643.1_Silent_p.L692L|YY1AP1_ENST00000347088.5_Silent_p.L712L|MSTO1_ENST00000452804.2_Intron|YY1AP1_ENST00000361831.5_Silent_p.L701L|YY1AP1_ENST00000368339.5_Silent_p.L850L|YY1AP1_ENST00000407221.1_Silent_p.L681L|MSTO1_ENST00000538143.1_Intron|YY1AP1_ENST00000359205.5_Silent_p.L701L|YY1AP1_ENST00000295566.4_Silent_p.L758L|YY1AP1_ENST00000535662.1_Silent_p.L558L|YY1AP1_ENST00000368330.2_Silent_p.L712L|YY1AP1_ENST00000311573.5_Silent_p.L681L|YY1AP1_ENST00000355499.4_Silent_p.L712L	NM_001198904.1	NP_001185833.1			YY1 associated protein 1											central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|liver(1)|lung(7)|ovary(2)|skin(2)|urinary_tract(2)	31	Hepatocellular(266;0.0997)|all_hematologic(923;0.145)					AGCGGCTCCAGAGCTTGCCTT	0.532000													27	97					0	0	1	0	0
LMOD2	442721	broad.mit.edu	37	7	123302493	123302493	+	Missense_Mutation	SNP	A	A	G			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr7:123302493A>G	ENST00000458573.2	+	2	1010	c.853A>G	c.(853-855)Atc>Gtc	p.I285V	LMOD2_ENST00000456238.2_Intron	NM_207163.1	NP_997046.1	Q6P5Q4	LMOD2_HUMAN	leiomodin 2 (cardiac)	285						cytoskeleton	actin binding|tropomyosin binding										GGGAAAGGGGATCCTGGCCAT	0.537000													4	86					0	0	1	0	0
C1QTNF1	114897	broad.mit.edu	37	17	77042772	77042772	+	Missense_Mutation	SNP	G	G	C			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr17:77042772G>C	ENST00000339142.2	+	4	846	c.291G>C	c.(289-291)ttG>ttC	p.L97F	C1QTNF1_ENST00000580454.1_Missense_Mutation_p.L97F|C1QTNF1_ENST00000354124.3_Missense_Mutation_p.L107F|C1QTNF1_ENST00000579760.1_Missense_Mutation_p.L97F|C1QTNF1_ENST00000311661.4_Missense_Mutation_p.L15F|C1QTNF1_ENST00000581774.1_Missense_Mutation_p.L97F|C1QTNF1_ENST00000580474.1_Missense_Mutation_p.L97F|C1QTNF1_ENST00000583904.1_Missense_Mutation_p.L97F|C1QTNF1_ENST00000578229.1_Missense_Mutation_p.L15F|C1QTNF1_ENST00000392445.2_Missense_Mutation_p.L97F	NM_198593.3	NP_940995.1	Q9BXJ1	C1QT1_HUMAN	C1q and tumor necrosis factor related protein 1	97						collagen				breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(5)|ovary(2)	14			BRCA - Breast invasive adenocarcinoma(99;0.0294)|OV - Ovarian serous cystadenocarcinoma(97;0.201)			TCACTATCTTGAAAGGTCAGA	0.632000											OREG0024791	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	24	111					0	0	1	0	0
ARHGAP19-SLIT1	100533184	broad.mit.edu	37	10	99003770	99003770	+	Silent	SNP	A	A	T			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr10:99003770A>T	ENST00000453547.2	-	8	1139	c.1140T>A	c.(1138-1140)gtT>gtA	p.V380V	ARHGAP19-SLIT1_ENST00000316676.8_Silent_p.V380V|ARHGAP19_ENST00000487035.1_5'UTR|ARHGAP19-SLIT1_ENST00000358308.3_Silent_p.V351V|ARHGAP19_ENST00000371027.1_Silent_p.V371V|ARHGAP19_ENST00000358531.4_Silent_p.V380V|ARHGAP19_ENST00000355366.5_Silent_p.V371V																							GCATATCATGAACGTGTTGAA	0.493000													38	28					0	0	1	0	0
HERC2	8924	broad.mit.edu	37	15	28420727	28420727	+	Silent	SNP	C	C	G			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr15:28420727C>G	ENST00000261609.7	-	64	9870	c.9762G>C	c.(9760-9762)ctG>ctC	p.L3254L		NM_004667.5	NP_004658.3	O95714	HERC2_HUMAN	HECT and RLD domain containing E3 ubiquitin protein ligase 2	3254					DNA repair|intracellular protein transport|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	guanyl-nucleotide exchange factor activity|heme binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(3)|central_nervous_system(3)|cervix(3)|endometrium(20)|kidney(11)|large_intestine(33)|lung(95)|ovary(7)|prostate(8)|skin(7)|upper_aerodigestive_tract(8)|urinary_tract(4)	204		all_lung(180;1.3e-11)|Breast(32;0.000194)|Colorectal(260;0.227)		all cancers(64;3.93e-09)|Epithelial(43;9.99e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0271)|GBM - Glioblastoma multiforme(186;0.0497)|Lung(196;0.199)		TCTTCCCTCTCAGCCCTTCCA	0.642000													7	18					0	0	1	0	0
ARFGAP1	55738	broad.mit.edu	37	20	61919026	61919026	+	Missense_Mutation	SNP	G	G	A			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr20:61919026G>A	ENST00000370283.4	+	13	1162	c.1022G>A	c.(1021-1023)cGc>cAc	p.R341H	ARFGAP1_ENST00000519273.2_Missense_Mutation_p.R228H|ARFGAP1_ENST00000547204.1_Missense_Mutation_p.R275H|ARFGAP1_ENST00000519604.1_Missense_Mutation_p.R296H|ARFGAP1_ENST00000370275.4_3'UTR|ARFGAP1_ENST00000518794.2_3'UTR|ARFGAP1_ENST00000353546.3_Missense_Mutation_p.R349H	NM_018209.2	NP_060679.1	Q8N6T3	ARFG1_HUMAN	ADP-ribosylation factor GTPase activating protein 1	341					COPI coating of Golgi vesicle|protein transport|regulation of ARF GTPase activity|retrograde vesicle-mediated transport, Golgi to ER	cytosol|Golgi-associated vesicle membrane	ARF GTPase activator activity|zinc ion binding			endometrium(2)|kidney(2)|large_intestine(1)|lung(6)|ovary(1)|pancreas(1)	13	all_cancers(38;1.59e-09)					ACCAAGACCCGCAAGTCCCCG	0.617000													5	13					0	0	1	0	0
C16orf87	388272	broad.mit.edu	37	16	46836867	46836867	+	Silent	SNP	G	G	C			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr16:46836867G>C	ENST00000394806.2	-	3	291	c.279C>G	c.(277-279)ctC>ctG	p.L93L	C16orf87_ENST00000285697.4_Silent_p.L154L			Q6PH81	CP087_HUMAN	chromosome 16 open reading frame 87	154										large_intestine(4)|urinary_tract(1)	5						ACAAGTATCAGAGAATAAGTC	0.358000													11	25					0	0	1	0	0
VPS13D	55187	broad.mit.edu	37	1	12460348	12460348	+	Silent	SNP	G	G	T			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr1:12460348G>T	ENST00000358136.3	+	61	11875	c.11745G>T	c.(11743-11745)gtG>gtT	p.V3915V	VPS13D_ENST00000356315.4_Silent_p.V3890V|VPS13D_ENST00000496628.1_3'UTR	NM_015378.2	NP_056193.2	Q5THJ4	VP13D_HUMAN	vacuolar protein sorting 13 homolog D (S. cerevisiae)	3914					protein localization					NS(1)|breast(6)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(28)|lung(44)|ovary(5)|pancreas(1)|prostate(8)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(4)	130	Ovarian(185;0.249)	Lung NSC(185;4.08e-05)|all_lung(284;4.55e-05)|Renal(390;0.000147)|Colorectal(325;0.00058)|Breast(348;0.00093)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0327)|Colorectal(212;4.63e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000289)|COAD - Colon adenocarcinoma(227;0.000801)|Kidney(185;0.00216)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(313;0.012)|READ - Rectum adenocarcinoma(331;0.0476)|Lung(427;0.209)		TCAACGCAGTGAAGTTCCCCA	0.537000													13	34					1.5842e-08	1.65351e-08	1	1	0
ADAMTS20	80070	broad.mit.edu	37	12	43944794	43944794	+	Missense_Mutation	SNP	G	G	A			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr12:43944794G>A	ENST00000389420.3	-	2	370	c.371C>T	c.(370-372)tCg>tTg	p.S124L	ADAMTS20_ENST00000553158.1_Missense_Mutation_p.S124L	NM_025003.3	NP_079279.3	P59510	ATS20_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 20	124						proteinaceous extracellular matrix	zinc ion binding	p.S124*(2)		breast(1)|central_nervous_system(6)|endometrium(3)|kidney(4)|large_intestine(11)|liver(1)|lung(43)|ovary(4)|pancreas(3)|prostate(5)|skin(12)|upper_aerodigestive_tract(1)|urinary_tract(1)	95	all_cancers(12;2.6e-05)|Lung SC(27;0.184)	Lung NSC(34;0.0569)|all_lung(34;0.129)		GBM - Glioblastoma multiforme(48;0.0473)		GCGCAGGTCCGAGGGCCCTGC	0.667000													17	15					0	0	1	0	0
ANKAR	150709	broad.mit.edu	37	2	190592617	190592617	+	Missense_Mutation	SNP	G	G	A			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr2:190592617G>A	ENST00000520309.1	+	13	2759	c.2671G>A	c.(2671-2673)Gag>Aag	p.E891K	ANKAR_ENST00000281412.6_Missense_Mutation_p.E666K|ANKAR_ENST00000438402.2_Missense_Mutation_p.E891K|ANKAR_ENST00000431575.2_Missense_Mutation_p.E820K|ANKAR_ENST00000313581.4_Missense_Mutation_p.E891K	NM_144708.3	NP_653309.3	Q7Z5J8	ANKAR_HUMAN	ankyrin and armadillo repeat containing	891						integral to membrane	binding			breast(3)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(7)|liver(2)|lung(16)|ovary(2)|pancreas(1)|skin(1)|urinary_tract(2)	46			OV - Ovarian serous cystadenocarcinoma(117;0.00156)|Epithelial(96;0.0256)|all cancers(119;0.0744)			TGCAATTGCTGAGGTTGGGCG	0.383000													14	50					0	0	1	0	0
PKD1L1	168507	broad.mit.edu	37	7	47897389	47897389	+	Silent	SNP	C	C	T			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr7:47897389C>T	ENST00000289672.2	-	28	4454	c.4404G>A	c.(4402-4404)gaG>gaA	p.E1468E		NM_138295.3	NP_612152.1	Q8TDX9	PK1L1_HUMAN	polycystic kidney disease 1 like 1	1468	REJ.				cell-cell adhesion	integral to membrane			BBS9/PKD1L1(2)	NS(1)|breast(9)|central_nervous_system(1)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(27)|lung(44)|ovary(12)|prostate(5)|skin(8)|stomach(4)|upper_aerodigestive_tract(5)	142						GGGTCCGGAACTCCATCTGCC	0.493000													13	41					0	0	1	0	0
ZFP2	80108	broad.mit.edu	37	5	178359501	178359501	+	Missense_Mutation	SNP	A	A	T			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr5:178359501A>T	ENST00000361362.2	+	5	1717	c.1187A>T	c.(1186-1188)tAc>tTc	p.Y396F	ZFP2_ENST00000523286.1_Missense_Mutation_p.Y396F|ZFP2_ENST00000520301.1_Missense_Mutation_p.Y396F|ZFP2_ENST00000503510.2_Missense_Mutation_p.Y396F	NM_030613.2	NP_085116.2	Q6ZN57	ZFP2_HUMAN	ZFP2 zinc finger protein	396					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|endometrium(2)|kidney(1)|large_intestine(7)|liver(1)|lung(2)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|stomach(1)	20	all_cancers(89;0.000639)|all_epithelial(37;0.000109)|Renal(175;0.000159)|Lung NSC(126;0.00199)|all_lung(126;0.00351)	all_neural(177;0.00802)|Medulloblastoma(196;0.0145)|all_hematologic(541;0.248)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.00655)|GBM - Glioblastoma multiforme(465;0.0302)|OV - Ovarian serous cystadenocarcinoma(192;0.0615)|Epithelial(171;0.111)		CAGAGTGCTTACCTTATTGAA	0.423000													20	24					0	0	1	0	0
UBFD1	56061	broad.mit.edu	37	16	23570965	23570965	+	Missense_Mutation	SNP	G	G	A			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr16:23570965G>A	ENST00000395878.3	+	3	913	c.532G>A	c.(532-534)Gag>Aag	p.E178K	UBFD1_ENST00000567212.1_Missense_Mutation_p.E169K|UBFD1_ENST00000219638.4_Missense_Mutation_p.E402K|UBFD1_ENST00000571064.1_3'UTR|UBFD1_ENST00000567264.1_Missense_Mutation_p.E178K	NM_019116.2	NP_061989.2	O14562	UBFD1_HUMAN	ubiquitin family domain containing 1	178										endometrium(1)|kidney(1)|large_intestine(2)|lung(3)	7				GBM - Glioblastoma multiforme(48;0.0331)		AAAGGCCGAAGAGAACAAGAA	0.507000													11	72					0	0	1	0	0
MED13	9969	broad.mit.edu	37	17	60039055	60039055	+	Missense_Mutation	SNP	G	G	A			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr17:60039055G>A	ENST00000397786.2	-	22	5226	c.5150C>T	c.(5149-5151)tCg>tTg	p.S1717L		NM_005121.2	NP_005112.2	Q9UHV7	MED13_HUMAN	mediator complex subunit 13	1717					androgen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			breast(4)|central_nervous_system(1)|endometrium(10)|kidney(24)|large_intestine(15)|liver(1)|lung(20)|ovary(1)|prostate(3)|skin(2)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	88						GGTAAAGGCCGAAAAAGCCAG	0.443000													35	133					0	0	1	0	0
GRIA4	2893	broad.mit.edu	37	11	105769096	105769096	+	Missense_Mutation	SNP	G	G	A			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr11:105769096G>A	ENST00000393127.2	+	7	1274	c.828G>A	c.(826-828)atG>atA	p.M276I	GRIA4_ENST00000282499.5_Missense_Mutation_p.M276I|GRIA4_ENST00000393125.2_Missense_Mutation_p.M276I|GRIA4_ENST00000530497.1_Missense_Mutation_p.M276I|GRIA4_ENST00000525187.1_Missense_Mutation_p.M276I|GRIA4_ENST00000428631.2_Missense_Mutation_p.M276I	NM_001077243.2	NP_001070711	P48058	GRIA4_HUMAN	glutamate receptor, ionotropic, AMPA 4	276					glutamate signaling pathway|synaptic transmission	cell junction|endocytic vesicle membrane|integral to membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(24)|liver(2)|lung(25)|ovary(4)|pancreas(1)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(6)	82		Melanoma(852;0.000902)|Acute lymphoblastic leukemia(157;0.000994)|all_hematologic(158;0.0017)|Breast(348;0.0323)		BRCA - Breast invasive adenocarcinoma(274;0.000147)|Epithelial(105;0.0291)|all cancers(92;0.0899)	L-Glutamic Acid(DB00142)	TCAAACTAATGGATCGCTGGA	0.363000													15	13					0	0	1	0	0
COG7	91949	broad.mit.edu	37	16	23415145	23415145	+	Nonsense_Mutation	SNP	G	G	C			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr16:23415145G>C	ENST00000307149.5	-	13	1858	c.1673C>G	c.(1672-1674)tCa>tGa	p.S558*		NM_153603.3	NP_705831.1	P83436	COG7_HUMAN	component of oligomeric golgi complex 7	558					intracellular protein transport|protein glycosylation|protein localization in Golgi apparatus|protein stabilization|retrograde vesicle-mediated transport, Golgi to ER	Golgi membrane|Golgi transport complex	protein binding			breast(1)|central_nervous_system(1)|endometrium(7)|large_intestine(9)|liver(1)|lung(7)|urinary_tract(1)	27				GBM - Glioblastoma multiforme(48;0.0401)		GTGGTTGCTTGACCCTTTTTC	0.493000													35	29					0	0	1	0	0
TSGA10IP	254187	broad.mit.edu	37	11	65713282	65713282	+	RNA	SNP	C	C	G			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr11:65713282C>G	ENST00000608857.1	+	0	136				TSGA10IP_ENST00000532620.1_RNA	NM_152762.2	NP_689975.2	Q3SY00	T10IP_HUMAN	testis specific, 10 interacting protein											endometrium(2)|kidney(3)|lung(9)	14						GACCGTCTCTCAGGACAAGCA	0.647000													37	40					0	0	1	0	0
PCDHA7	56141	broad.mit.edu	37	5	140215433	140215433	+	Silent	SNP	C	C	T			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr5:140215433C>T	ENST00000525929.1	+	1	1465	c.1465C>T	c.(1465-1467)Ctg>Ttg	p.L489L	PCDHA6_ENST00000529310.1_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA7_ENST00000378125.3_Silent_p.L489L	NM_018910.2	NP_061733.1														NS(2)|biliary_tract(1)|breast(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(27)|ovary(3)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	63			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GAAGAACGCGCTGGTGTCCTA	0.677000													36	100					0	0	1	0	0
COL6A2	1292	broad.mit.edu	37	21	47532167	47532167	+	Silent	SNP	C	C	T			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr21:47532167C>T	ENST00000300527.4	+	3	494	c.390C>T	c.(388-390)cgC>cgT	p.R130R	COL6A2_ENST00000310645.5_Silent_p.R130R|COL6A2_ENST00000397763.1_Silent_p.R130R|COL6A2_ENST00000357838.4_Silent_p.R130R|COL6A2_ENST00000409416.1_Silent_p.R130R	NM_001849.3	NP_001840.3	P12110	CO6A2_HUMAN	collagen, type VI, alpha 2	130	Nonhelical region.|VWFA 1.				axon guidance|cell-cell adhesion|extracellular matrix organization|protein heterotrimerization	collagen|extracellular space|protein complex	extracellular matrix structural constituent|protein binding, bridging			NS(1)|breast(1)|central_nervous_system(7)|endometrium(7)|kidney(5)|liver(1)|lung(15)|ovary(2)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	43	Breast(49;0.245)			Colorectal(79;0.0303)|READ - Rectum adenocarcinoma(84;0.0649)		CCTTCCGCCGCGGCACCTTCA	0.672000													26	38					0	0	1	0	0
NCOA2	10499	broad.mit.edu	37	8	71041012	71041012	+	Silent	SNP	G	G	C			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr8:71041012G>C	ENST00000452400.2	-	17	3709	c.3528C>G	c.(3526-3528)ctC>ctG	p.L1176L	NCOA2_ENST00000267974.4_Silent_p.L264L	NM_006540.2	NP_006531.1	Q15596	NCOA2_HUMAN	nuclear receptor coactivator 2	1176					cellular lipid metabolic process|transcription, DNA-dependent	nucleoplasm	histone acetyltransferase activity|ligand-dependent nuclear receptor binding|nuclear hormone receptor binding|signal transducer activity		PAX3/NCOA2(4)|HEY1/NCOA2(10)	NS(1)|breast(4)|endometrium(7)|kidney(4)|large_intestine(10)|lung(25)|ovary(1)|pancreas(2)|prostate(2)|skin(4)	60	Breast(64;0.201)		Epithelial(68;0.0147)|OV - Ovarian serous cystadenocarcinoma(28;0.0455)|all cancers(69;0.0606)			CCGTGGGCCTGAGGCCCGGTC	0.562000			T	"""RUNXBP2, HEY1"""	"""AML, Chondrosarcoma"""								14	78					0	0	1	0	0
ATP6V0E2	155066	broad.mit.edu	37	7	149575806	149575806	+	Missense_Mutation	SNP	C	C	A			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr7:149575806C>A	ENST00000456496.2	+	3	1290	c.339C>A	c.(337-339)ttC>ttA	p.F113L	ATP6V0E2_ENST00000425642.2_Missense_Mutation_p.F64L|ATP6V0E2_ENST00000495408.1_3'UTR|ATP6V0E2_ENST00000464662.1_Missense_Mutation_p.F64L|ATP6V0E2_ENST00000606024.1_Intron|ATP6V0E2_ENST00000421974.2_Intron|ATP6V0E2-AS1_ENST00000464939.1_RNA|ATP6V0E2_ENST00000479613.1_Missense_Mutation_p.F64L	NM_145230.2	NP_660265.2	Q8NHE4	VA0E2_HUMAN	ATPase, H+ transporting V0 subunit e2	64					ATP hydrolysis coupled proton transport|cell growth|cellular iron ion homeostasis|insulin receptor signaling pathway|transferrin transport|vacuolar acidification	endosome membrane|integral to membrane|proton-transporting V-type ATPase, V0 domain|vacuole	ATPase activity, coupled to transmembrane movement of ions|hydrogen ion transmembrane transporter activity			lung(1)	1			OV - Ovarian serous cystadenocarcinoma(82;0.00256)			ACCCCCTGTTCGGGCCCCAGC	0.662000													57	21					6.1719e-39	6.85615e-39	1	1	0
SMYD5	10322	broad.mit.edu	37	2	73441405	73441405	+	Missense_Mutation	SNP	C	C	G			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr2:73441405C>G	ENST00000389501.4	+	1	56	c.11C>G	c.(10-12)tCc>tGc	p.S4C		NM_006062.2	NP_006053.2	Q6GMV2	SMYD5_HUMAN	SMYD family member 5	4							metal ion binding			NS(1)|breast(1)|endometrium(1)|large_intestine(3)|lung(5)|pancreas(1)|upper_aerodigestive_tract(1)	13						ATGGCGGCCTCCATGTGCGAC	0.706000													101	316					0	0	1	0	0
C10orf67	256815	broad.mit.edu	37	10	23622056	23622056	+	Nonsense_Mutation	SNP	G	G	A			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr10:23622056G>A	ENST00000323327.4	-	2	332	c.265C>T	c.(265-267)Caa>Taa	p.Q89*		NM_153714.2	NP_714925.2	Q8IYJ2	CJ067_HUMAN	chromosome 10 open reading frame 67	89										central_nervous_system(1)|endometrium(1)|lung(2)|pancreas(1)	5						GAATCAGTTTGAGTGGCATGG	0.328000													22	16					0	0	1	0	0
CSNK2B	1460	broad.mit.edu	37	6	31637174	31637174	+	Nonsense_Mutation	SNP	C	C	G			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr6:31637174C>G	ENST00000375880.2	+	6	564	c.446C>G	c.(445-447)tCa>tGa	p.S149*	CSNK2B_ENST00000375885.4_Nonsense_Mutation_p.S168*|CSNK2B_ENST00000375866.2_Nonsense_Mutation_p.S149*|CSNK2B_ENST00000375882.2_Nonsense_Mutation_p.S149*|CSNK2B_ENST00000375865.2_Nonsense_Mutation_p.S149*																							CCCAAGTCATCAAGACACCAT	0.567000													13	69					0	0	1	0	0
MFRP	83552	broad.mit.edu	37	11	119216562	119216562	+	Silent	SNP	G	G	A			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr11:119216562G>A	ENST00000555262.1	-	4	507	c.348C>T	c.(346-348)acC>acT	p.T116T	MFRP_ENST00000360167.4_Silent_p.T116T|C1QTNF5_ENST00000445041.2_5'UTR|MFRP_ENST00000530681.1_Silent_p.T116T|MFRP_ENST00000449574.2_Silent_p.T116T|MFRP_ENST00000529147.1_5'UTR	NM_001278431.1	NP_001265360.1			membrane frizzled-related protein											autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(8)|prostate(1)|urinary_tract(1)	18		Medulloblastoma(222;0.0523)|Breast(348;0.174)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;3.84e-05)		tgatggtgggggtggtggtgg	0.657000													62	39					0	0	1	0	0
GPR98	84059	broad.mit.edu	37	5	89968399	89968399	+	Missense_Mutation	SNP	G	G	A			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr5:89968399G>A	ENST00000405460.2	+	22	4885	c.4789G>A	c.(4789-4791)Gag>Aag	p.E1597K	GPR98_ENST00000450321.2_3'UTR	NM_032119.3	NP_115495.3	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98	1597					cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(4)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(18)|large_intestine(46)|liver(2)|lung(80)|ovary(12)|pancreas(5)|prostate(1)|skin(50)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(6)	269		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		TTGTGTGGTTGAGAGAACCAG	0.358000													8	26					0	0	1	0	0
PLEKHA4	57664	broad.mit.edu	37	19	49362886	49362886	+	Missense_Mutation	SNP	C	C	T			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr19:49362886C>T	ENST00000263265.6	-	7	1087	c.532G>A	c.(532-534)Ggt>Agt	p.G178S	PLEKHA4_ENST00000596713.1_5'UTR|PLEKHA4_ENST00000355496.5_Missense_Mutation_p.G178S	NM_020904.2	NP_065955.2	Q9H4M7	PKHA4_HUMAN	pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4	178	Pro-rich.					cytoplasm|membrane	1-phosphatidylinositol binding			NS(1)|breast(5)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(5)|ovary(1)|prostate(3)|skin(2)|urinary_tract(2)	30		all_lung(116;4.89e-05)|Lung NSC(112;8.3e-05)|all_epithelial(76;0.000108)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.00027)|all cancers(93;0.00084)|GBM - Glioblastoma multiforme(486;0.0244)|Epithelial(262;0.0364)		GGGGGACCACCGGGGCCGCCG	0.632000													22	24					0	0	1	0	0
CD28	940	broad.mit.edu	37	2	204591441	204591441	+	Silent	SNP	C	C	T			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr2:204591441C>T	ENST00000324106.8	+	2	287	c.138C>T	c.(136-138)ctC>ctT	p.L46L	CD28_ENST00000374478.4_Intron|CD28_ENST00000374481.3_Intron|CD28_ENST00000458610.2_Silent_p.L60L	NM_001243077.1|NM_006139.3	NP_001230006.1|NP_006130.1	P10747	CD28_HUMAN	CD28 molecule		Ig-like V-type.				cell surface receptor linked signaling pathway|cytokine biosynthetic process|humoral immune response|positive regulation of anti-apoptosis|positive regulation of interleukin-2 biosynthetic process|positive regulation of mitosis|positive regulation of translation|positive regulation of viral genome replication|regulation of defense response to virus by virus|regulatory T cell differentiation|T cell costimulation|viral reproduction	cytosol|external side of plasma membrane|integral to plasma membrane	coreceptor activity|protease binding|SH3/SH2 adaptor activity			endometrium(1)|kidney(2)|large_intestine(4)|lung(3)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	13						CCTACAATCTCTTCTCAAGGG	0.468000													16	50					0	0	1	0	0
TCHP	84260	broad.mit.edu	37	12	110341781	110341781	+	Missense_Mutation	SNP	G	G	C			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr12:110341781G>C	ENST00000312777.5	+	3	442	c.228G>C	c.(226-228)aaG>aaC	p.K76N	TCHP_ENST00000405876.4_Missense_Mutation_p.K76N	NM_032300.4	NP_115676.1	Q9BT92	TCHP_HUMAN	trichoplein, keratin filament binding	76	Glu-rich.|Interaction with keratin proteins.				apoptosis|negative regulation of cell growth	apical cortex|centrosome|keratin filament|mitochondrion|plasma membrane	protein binding			NS(1)|breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(8)|ovary(1)|skin(2)	22						AGGAGGAGAAGAGGAGGAGTC	0.592000													8	9					0	0	1	0	0
SALL3	27164	broad.mit.edu	37	18	76753365	76753365	+	Silent	SNP	C	C	A			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr18:76753365C>A	ENST00000536229.3	+	1	1684	c.975C>A	c.(973-975)tcC>tcA	p.S325S	SALL3_ENST00000537592.2_Silent_p.S458S|SALL3_ENST00000575389.2_Silent_p.S458S			Q9BXA9	SALL3_HUMAN	spalt-like transcription factor 3	458					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(2)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(8)|lung(40)|ovary(4)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	74		Esophageal squamous(42;0.129)|Melanoma(33;0.16)|Prostate(75;0.167)		OV - Ovarian serous cystadenocarcinoma(15;4.69e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0256)		ACCGCTTCTCCACCAAAGGCA	0.617000													9	20					1.58986e-06	1.63893e-06	1	1	0
PTPRG	5793	broad.mit.edu	37	3	62142873	62142873	+	Missense_Mutation	SNP	G	G	C			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr3:62142873G>C	ENST00000474889.1	+	7	1192	c.815G>C	c.(814-816)aGa>aCa	p.R272T	PTPRG_ENST00000295874.10_Missense_Mutation_p.R272T	NM_002841.3	NP_002832.3	P23470	PTPRG_HUMAN	protein tyrosine phosphatase, receptor type, G	272	Alpha-carbonic anhydrase.				transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	identical protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(4)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(12)|liver(2)|lung(15)|ovary(7)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	62				BRCA - Breast invasive adenocarcinoma(55;0.000376)|KIRC - Kidney renal clear cell carcinoma(10;0.0499)|Kidney(10;0.065)		GTCTTCCGGAGACCCGTCCCC	0.502000													5	76					0	0	1	0	0
SEC63	11231	broad.mit.edu	37	6	108197836	108197836	+	Missense_Mutation	SNP	C	C	T			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr6:108197836C>T	ENST00000369002.4	-	19	2145	c.1966G>A	c.(1966-1968)Gca>Aca	p.A656T		NM_007214.4	NP_009145.1	Q9UGP8	SEC63_HUMAN	SEC63 homolog (S. cerevisiae)	656	SEC63 2.				protein folding|protein targeting to membrane	endoplasmic reticulum membrane|integral to membrane	heat shock protein binding|receptor activity|unfolded protein binding			endometrium(3)|kidney(4)|large_intestine(7)|lung(14)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	36		all_cancers(87;5.35e-06)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;0.00225)|Colorectal(196;0.0294)		BRCA - Breast invasive adenocarcinoma(108;0.0079)|Epithelial(106;0.0356)|all cancers(137;0.0525)|OV - Ovarian serous cystadenocarcinoma(136;0.054)		TTCCTATCTGCAATGTAAAGC	0.333000													40	43					0	0	1	0	0
DNAH2	146754	broad.mit.edu	37	17	7695372	7695372	+	Silent	SNP	C	C	T			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr17:7695372C>T	ENST00000572933.1	+	45	8498	c.7038C>T	c.(7036-7038)ggC>ggT	p.G2346G	DNAH2_ENST00000389173.2_Silent_p.G2346G			Q9P225	DYH2_HUMAN	dynein, axonemal, heavy chain 2	2346					ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(3)|breast(11)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(2)|kidney(16)|large_intestine(53)|liver(2)|lung(49)|ovary(7)|prostate(7)|skin(15)|upper_aerodigestive_tract(1)|urinary_tract(1)	189		all_cancers(10;4.66e-07)|Prostate(122;0.081)				AGATCGAGGGCTCCTTTCCCA	0.557000													31	9					0	0	1	0	0
SPTBN2	6712	broad.mit.edu	37	11	66472142	66472142	+	Missense_Mutation	SNP	C	C	G			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr11:66472142C>G	ENST00000533211.1	-	15	2936	c.2605G>C	c.(2605-2607)Gag>Cag	p.E869Q	SPTBN2_ENST00000529997.1_Missense_Mutation_p.E869Q|SPTBN2_ENST00000309996.2_Missense_Mutation_p.E869Q			O15020	SPTN2_HUMAN	spectrin, beta, non-erythrocytic 2	869					actin filament capping|axon guidance|cell death|vesicle-mediated transport	cytosol|spectrin	actin binding|structural constituent of cytoskeleton			autonomic_ganglia(1)|breast(1)|central_nervous_system(4)|cervix(1)|endometrium(10)|kidney(5)|large_intestine(15)|liver(1)|lung(22)|ovary(2)|pancreas(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	74						TCCTTCTCCTCCACCCAGAGT	0.701000													6	10					0	0	1	0	0
TMEM45B	120224	broad.mit.edu	37	11	129727291	129727291	+	Silent	SNP	C	C	T			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr11:129727291C>T	ENST00000281441.3	+	5	742	c.654C>T	c.(652-654)tgC>tgT	p.C218C	TMEM45B_ENST00000524567.1_Silent_p.C218C	NM_138788.3	NP_620143.1	Q96B21	TM45B_HUMAN	transmembrane protein 45B	218						integral to membrane				endometrium(2)|kidney(1)|large_intestine(2)|lung(5)|skin(1)|stomach(1)	12	all_hematologic(175;0.0537)	Breast(109;0.00526)|Lung NSC(97;0.00901)|all_lung(97;0.018)|Medulloblastoma(222;0.0523)|all_neural(223;0.186)		OV - Ovarian serous cystadenocarcinoma(99;0.012)|Lung(977;0.179)|LUSC - Lung squamous cell carcinoma(976;0.189)		TCACCATGTGCTTCTGCTGGC	0.488000													24	64					0	0	1	0	0
AICDA	57379	broad.mit.edu	37	12	8757469	8757469	+	Silent	SNP	G	G	A			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr12:8757469G>A	ENST00000229335.6	-	4	580	c.477C>T	c.(475-477)ttC>ttT	p.F159F	AICDA_ENST00000537228.1_Silent_p.F149F	NM_020661.2	NP_065712.1	Q9GZX7	AICDA_HUMAN	activation-induced cytidine deaminase	159					B cell differentiation|DNA demethylation|mRNA processing|negative regulation of methylation-dependent chromatin silencing	cytoplasm	cytidine deaminase activity|protein binding|zinc ion binding			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(4)|ovary(2)|pancreas(1)	16	Lung SC(5;0.184)					CCCAGGCTTTGAAAGTTCTTT	0.403000													68	51					0	0	1	0	0
DENND6B	414918	broad.mit.edu	37	22	50752281	50752281	+	Missense_Mutation	SNP	G	G	A			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr22:50752281G>A	ENST00000413817.3	-	14	1236	c.1165C>T	c.(1165-1167)Ctc>Ttc	p.L389F		NM_001001794.3	NP_001001794.3			DENN/MADD domain containing 6B																		TCGCGGTGGAGGTGGGCCGTG	0.672000													8	16					0	0	1	0	0
COL5A2	1290	broad.mit.edu	37	2	189909916	189909916	+	Missense_Mutation	SNP	G	G	A			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr2:189909916G>A	ENST00000374866.3	-	47	3626	c.3352C>T	c.(3352-3354)Cgt>Tgt	p.R1118C		NM_000393.3	NP_000384.2	P05997	CO5A2_HUMAN	collagen, type V, alpha 2	1118					axon guidance|collagen fibril organization|eye morphogenesis|skin development	collagen type V	extracellular matrix structural constituent			NS(3)|breast(2)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(16)|lung(53)|ovary(3)|prostate(2)|skin(6)|urinary_tract(3)	95			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.127)			GGTAATCCACGTTTCCCAGCT	0.299000													12	15					0	0	1	0	0
ZNF439	90594	broad.mit.edu	37	19	11977127	11977127	+	Missense_Mutation	SNP	C	C	G			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr19:11977127C>G	ENST00000304030.2	+	1	356	c.156C>G	c.(154-156)ttC>ttG	p.F52L	ZNF439_ENST00000455282.1_Intron|ZNF439_ENST00000592534.1_Intron	NM_152262.2	NP_689475.1	Q8NDP4	ZN439_HUMAN	zinc finger protein 439	52	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(7)|pancreas(1)|skin(2)	27						TGGAAACTTTCTGGAACCTGA	0.443000													74	63					0	0	1	0	0
KAT5	10524	broad.mit.edu	37	11	65480937	65480937	+	Missense_Mutation	SNP	C	C	T			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr11:65480937C>T	ENST00000341318.4	+	4	737	c.503C>T	c.(502-504)tCc>tTc	p.S168F	KAT5_ENST00000534650.1_Intron|KAT5_ENST00000530446.1_Intron|KAT5_ENST00000377046.3_Missense_Mutation_p.S135F|KAT5_ENST00000525204.1_3'UTR|KAT5_ENST00000352980.4_Intron	NM_182710.2	NP_874369.1	Q92993	KAT5_HUMAN	K(lysine) acetyltransferase 5	135					androgen receptor signaling pathway|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|double-strand break repair|interspecies interaction between organisms|negative regulation of interleukin-2 production|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|regulation of growth|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nucleolus|perinuclear region of cytoplasm|Piccolo NuA4 histone acetyltransferase complex	androgen receptor binding|histone acetyltransferase activity|metal ion binding|repressing transcription factor binding|transcription coactivator activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(9)	21						CAGCCGCTCTCCTCCAGCTCC	0.617000													57	36					0	0	1	0	0
LRP1B	53353	broad.mit.edu	37	2	141533778	141533778	+	Missense_Mutation	SNP	A	A	C			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr2:141533778A>C	ENST00000389484.3	-	33	6360	c.5389T>G	c.(5389-5391)Tta>Gta	p.L1797V		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	1797					protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		AGCTGGGCTAAGTTTTGGTCT	0.343000										TSP Lung(27;0.18)			5	21					0	0	1	0	0
MICALL1	85377	broad.mit.edu	37	22	38327865	38327865	+	Silent	SNP	A	A	G			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr22:38327865A>G	ENST00000215957.6	+	10	2067	c.1941A>G	c.(1939-1941)acA>acG	p.T647T	MICALL1_ENST00000402631.1_3'UTR	NM_033386.3	NP_203744.1	Q8N3F8	MILK1_HUMAN	MICAL-like 1	647	Pro-rich.					cytoplasm|cytoskeleton	protein binding|zinc ion binding			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(8)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	24	Melanoma(58;0.045)					CCCCAGCCACAAAGAAGGCCA	0.587000													36	54					0	0	1	0	0
ZNF827	152485	broad.mit.edu	37	4	146823326	146823326	+	Missense_Mutation	SNP	G	G	C			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr4:146823326G>C	ENST00000508784.1	-	2	1312	c.1085C>G	c.(1084-1086)tCc>tGc	p.S362C	ZNF827_ENST00000379448.4_Missense_Mutation_p.S362C|ZNF827_ENST00000513320.1_Intron			Q17R98	ZN827_HUMAN	zinc finger protein 827	362					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(13)|lung(18)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	48	all_hematologic(180;0.151)					ACCTGAATTGGAGGGTTTAGA	0.458000													15	7					0	0	1	0	0
PABPC4	8761	broad.mit.edu	37	1	40034501	40034501	+	Silent	SNP	C	C	T			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr1:40034501C>T	ENST00000372857.3	-	6	1641	c.849G>A	c.(847-849)ttG>ttA	p.L283L	PABPC4_ENST00000372862.3_Silent_p.L283L|PABPC4_ENST00000372856.3_Silent_p.L283L|RP11-69E11.8_ENST00000415255.1_RNA|PABPC4_ENST00000372858.3_Silent_p.L283L	NM_003819.3	NP_003810.1	Q13310	PABP4_HUMAN	poly(A) binding protein, cytoplasmic 4 (inducible form)	283					blood coagulation|RNA catabolic process|RNA processing|translation	cytoplasm|ribonucleoprotein complex	nucleotide binding|poly(A) RNA binding|poly(U) RNA binding|protein binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(5)|liver(1)|lung(6)|prostate(1)|skin(3)	21	Lung NSC(20;1.55e-06)|Ovarian(52;0.00769)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;2.89e-18)|Epithelial(16;6.17e-17)|all cancers(16;1.18e-15)|LUSC - Lung squamous cell carcinoma(16;0.000261)|Lung(16;0.000457)			TCTCCTGTTTCAACTGTTCAA	0.408000													43	443					0	0	1	0	0
SLC5A3	6526	broad.mit.edu	37	21	35468865	35468865	+	Missense_Mutation	SNP	C	C	G			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr21:35468865C>G	ENST00000608209.1	+	2	1880	c.1368C>G	c.(1366-1368)ttC>ttG	p.F456L	SLC5A3_ENST00000381151.3_Missense_Mutation_p.F456L|AP000320.7_ENST00000362077.4_RNA|MRPS6_ENST00000399312.2_Intron	NM_006933.4	NP_008864.3	P53794	SC5A3_HUMAN	solute carrier family 5 (sodium/myo-inositol cotransporter), member 3							integral to plasma membrane	myo-inositol:sodium symporter activity			breast(1)|endometrium(4)|kidney(1)|large_intestine(2)|lung(7)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)	20						CAGCCTTGTTCCTGCTGGCAA	0.512000													19	68					0	0	1	0	0
S100A13	6284	broad.mit.edu	37	1	153598931	153598931	+	Silent	SNP	C	C	A			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr1:153598931C>A	ENST00000368699.1	-	4	521	c.18G>T	c.(16-18)ctG>ctT	p.L6L	S100A13_ENST00000339556.4_Silent_p.L6L|RP1-178F15.5_ENST00000497086.1_RNA|S100A13_ENST00000392622.1_Silent_p.L6L|S100A13_ENST00000392623.1_Silent_p.L6L|S100A13_ENST00000491177.1_5'UTR|S100A13_ENST00000440685.2_Silent_p.L6L	NM_001024210.1	NP_001019381.1	Q99584	S10AD_HUMAN	S100 calcium binding protein A13	6					interleukin-1 alpha secretion|mast cell degranulation|positive regulation of I-kappaB kinase/NF-kappaB cascade	cytosol|extracellular space|nucleus|perinuclear region of cytoplasm	calcium ion binding|copper ion binding|fibroblast growth factor 1 binding|lipid binding|protein homodimerization activity|RAGE receptor binding|zinc ion binding			breast(1)|endometrium(1)|large_intestine(1)|lung(4)	7	all_lung(78;1.84e-32)|Lung NSC(65;6.67e-31)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.171)		Amlexanox(DB01025)	CTAGCTCTGTCAGTGGTTCTG	0.557000													29	112					5.90632e-09	6.2035e-09	1	1	0
MDC1	9656	broad.mit.edu	37	6	30682949	30682949	+	Missense_Mutation	SNP	C	C	T			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr6:30682949C>T	ENST00000376406.3	-	2	651	c.4G>A	c.(4-6)Gag>Aag	p.E2K	MDC1_ENST00000376405.2_Missense_Mutation_p.E2K	NM_014641.2	NP_055456.2	Q14676	MDC1_HUMAN	mediator of DNA-damage checkpoint 1	2	Interaction with CHEK2.|Interaction with the MRN complex.				cell cycle|double-strand break repair via homologous recombination|intra-S DNA damage checkpoint	focal adhesion|nucleoplasm	FHA domain binding|protein C-terminus binding			breast(2)|kidney(1)|ovary(1)	4						TGGGTGTCCTCCATGATCTGG	0.463000								Other conserved DNA damage response genes					23	23					0	0	1	0	0
PUS10	150962	broad.mit.edu	37	2	61180158	61180158	+	Missense_Mutation	SNP	C	C	G			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr2:61180158C>G	ENST00000316752.6	-	15	1543	c.1282G>C	c.(1282-1284)Gac>Cac	p.D428H	PUS10_ENST00000407787.1_Missense_Mutation_p.D428H	NM_144709.2	NP_653310.2	Q3MIT2	PUS10_HUMAN	pseudouridylate synthase 10	428					pseudouridine synthesis|tRNA processing		pseudouridine synthase activity|RNA binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(8)|lung(8)|ovary(2)	22			LUSC - Lung squamous cell carcinoma(5;1.56e-06)|Lung(5;2.48e-05)|Epithelial(17;0.113)			AATTCAATGTCTTTCTTCTGT	0.318000													16	48					0	0	1	0	0
TUBA3E	112714	broad.mit.edu	37	2	130951796	130951796	+	Missense_Mutation	SNP	C	C	G			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr2:130951796C>G	ENST00000312988.7	-	4	719	c.619G>C	c.(619-621)Gaa>Caa	p.E207Q		NM_207312.2	NP_997195	Q6PEY2	TBA3E_HUMAN	tubulin, alpha 3e	207					microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|structural molecule activity			endometrium(4)|kidney(7)|large_intestine(6)|lung(9)|skin(2)	28	Colorectal(110;0.1)					TAGATGGCTTCATTGTCGACC	0.562000													27	62					0	0	1	0	0
SIN3B	23309	broad.mit.edu	37	19	16974540	16974540	+	Missense_Mutation	SNP	C	C	T			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr19:16974540C>T	ENST00000379803.1	+	11	1426	c.1412C>T	c.(1411-1413)aCg>aTg	p.T471M	SIN3B_ENST00000595541.1_Missense_Mutation_p.T29M|SIN3B_ENST00000248054.5_Missense_Mutation_p.T439M	NM_015260.2	NP_056075.1	O75182	SIN3B_HUMAN	SIN3 transcription regulator family member B	471	Interaction with NCOR1 (By similarity).|Interaction with SDS3 and HDAC1 (By similarity).				cellular lipid metabolic process|transcription, DNA-dependent	nucleoplasm	protein binding			endometrium(4)|kidney(2)|large_intestine(8)|lung(8)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	26						GAGGACTCCACGTTCGTCAGC	0.612000													18	27					0	0	1	0	0
HECTD1	25831	broad.mit.edu	37	14	31597995	31597995	+	Missense_Mutation	SNP	T	T	C			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr14:31597995T>C	ENST00000399332.1	-	25	5070	c.4582A>G	c.(4582-4584)Atg>Gtg	p.M1528V	HECTD1_ENST00000553700.1_Missense_Mutation_p.M1528V	NM_015382.2	NP_056197.2	Q9ULT8	HECD1_HUMAN	HECT domain containing E3 ubiquitin protein ligase 1	1528	Ser-rich.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	intracellular	metal ion binding|protein binding|ubiquitin-protein ligase activity			breast(10)|endometrium(7)|kidney(5)|large_intestine(12)|lung(23)|ovary(4)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	70	Hepatocellular(127;0.0877)|Breast(36;0.176)		LUAD - Lung adenocarcinoma(48;0.00292)|Lung(238;0.0164)|BRCA - Breast invasive adenocarcinoma(188;0.111)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.00617)		CTAGAGCTCATAGGGGCCCCA	0.453000													7	20					0	0	1	0	0
AFF2	2334	broad.mit.edu	37	X	148035156	148035156	+	Missense_Mutation	SNP	G	G	A			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chrX:148035156G>A	ENST00000370460.2	+	10	1923	c.1444G>A	c.(1444-1446)Ggg>Agg	p.G482R	AFF2_ENST00000342251.3_Missense_Mutation_p.G449R|AFF2_ENST00000286437.5_Missense_Mutation_p.G123R|AFF2_ENST00000370457.5_Missense_Mutation_p.G449R	NM_001169123.1|NM_002025.3	NP_001162594.1|NP_002016.2	P51816	AFF2_HUMAN	AF4/FMR2 family, member 2	482					brain development|mRNA processing|regulation of RNA splicing|RNA splicing	nuclear speck	G-quadruplex RNA binding|protein binding	p.G482R(2)|p.G123R(1)		breast(5)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(29)|liver(2)|lung(39)|ovary(4)|pancreas(5)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	109	Acute lymphoblastic leukemia(192;6.56e-05)					GCAAGCCAGCGGGGGTTCTGG	0.522000													75	15					0	0	1	0	0
FNBP4	23360	broad.mit.edu	37	11	47745674	47745674	+	Missense_Mutation	SNP	C	C	A			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr11:47745674C>A	ENST00000263773.5	-	14	2382	c.2370G>T	c.(2368-2370)aaG>aaT	p.K790N		NM_015308.2	NP_056123.2	Q8N3X1	FNBP4_HUMAN	formin binding protein 4	790										NS(1)|breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|lung(12)|ovary(3)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	44						TAGCTTTCCTCTTTATTCCTT	0.413000													14	32					3.27435e-08	3.4105e-08	1	1	0
DDHD1	80821	broad.mit.edu	37	14	53513515	53513515	+	Missense_Mutation	SNP	C	C	T			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr14:53513515C>T	ENST00000357758.3	-	12	2773	c.2590G>A	c.(2590-2592)Gat>Aat	p.D864N	DDHD1_ENST00000395606.1_Missense_Mutation_p.D871N|DDHD1_ENST00000323669.5_Missense_Mutation_p.D892N	NM_030637.2	NP_085140.2	Q8NEL9	DDHD1_HUMAN	DDHD domain containing 1	892	DDHD.				lipid catabolic process	cytoplasm	hydrolase activity|metal ion binding			breast(2)|cervix(1)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(4)|lung(11)|ovary(3)|prostate(1)	25	Breast(41;0.037)					GGTTTTGCATCATCATCGTGC	0.388000													35	18					0	0	1	0	0
ANK1	286	broad.mit.edu	37	8	41519023	41519023	+	Missense_Mutation	SNP	C	C	G			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr8:41519023C>G	ENST00000396942.1	-	42	5762	c.5679G>C	c.(5677-5679)caG>caC	p.Q1893H	RP11-930P14.1_ENST00000522388.1_RNA|ANK1_ENST00000314214.8_Missense_Mutation_p.Q143H|ANK1_ENST00000352337.4_Missense_Mutation_p.Q1846H|ANK1_ENST00000522231.1_Intron|RP11-930P14.1_ENST00000520418.1_RNA|ANK1_ENST00000347528.4_Intron|ANK1_ENST00000396945.1_Intron|ANK1_ENST00000379758.2_Intron|RP11-930P14.1_ENST00000585088.1_RNA|ANK1_ENST00000265709.8_Intron|ANK1_ENST00000457297.1_Intron|ANK1_ENST00000289734.7_Missense_Mutation_p.Q1868H|ANK1_ENST00000522543.1_Intron			P16157	ANK1_HUMAN	ankyrin 1, erythrocytic	0					axon guidance|cytoskeleton organization|exocytosis|maintenance of epithelial cell apical/basal polarity|signal transduction	basolateral plasma membrane|cytosol|sarcomere|sarcoplasmic reticulum|spectrin-associated cytoskeleton	cytoskeletal adaptor activity|enzyme binding|protein binding|spectrin binding|structural constituent of cytoskeleton			breast(5)|central_nervous_system(4)|endometrium(9)|kidney(1)|large_intestine(26)|lung(62)|ovary(3)|prostate(5)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	122	Ovarian(28;0.00541)|Colorectal(14;0.0398)|Lung SC(25;0.211)	all_lung(54;0.000626)|Lung NSC(58;0.00245)|Esophageal squamous(32;0.0559)|Hepatocellular(245;0.0663)|Renal(179;0.188)	OV - Ovarian serous cystadenocarcinoma(14;0.000984)|Lung(22;0.00108)|Colorectal(10;0.00245)|LUSC - Lung squamous cell carcinoma(45;0.00392)|COAD - Colon adenocarcinoma(11;0.0264)			GCTTCACTATCTGCGCCCCCT	0.612000													28	109					0	0	1	0	0
NPHP4	261734	broad.mit.edu	37	1	5947410	5947410	+	Silent	SNP	G	G	A			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr1:5947410G>A	ENST00000378156.4	-	18	2686	c.2421C>T	c.(2419-2421)cgC>cgT	p.R807R	NPHP4_ENST00000478423.2_5'UTR	NM_015102.3	NP_055917.1	O75161	NPHP4_HUMAN	nephronophthisis 4	807					actin cytoskeleton organization|cell-cell adhesion|signal transduction|visual behavior	cell-cell junction|centrosome|cilium|microtubule basal body	protein binding|structural molecule activity			NS(1)|breast(2)|cervix(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(15)|ovary(2)|pancreas(1)|prostate(4)	47	Ovarian(185;0.0634)	all_cancers(23;7.53e-41)|all_epithelial(116;3.96e-23)|all_lung(118;5.12e-09)|all_hematologic(16;5.45e-07)|Lung NSC(185;5.49e-07)|all_neural(13;3.21e-06)|Acute lymphoblastic leukemia(12;3.44e-05)|Breast(487;0.000601)|Renal(390;0.0007)|Colorectal(325;0.00113)|Hepatocellular(190;0.00213)|Glioma(11;0.00223)|Myeloproliferative disorder(586;0.0256)|Ovarian(437;0.04)|Lung SC(97;0.128)|Medulloblastoma(700;0.213)		Epithelial(90;1.69e-36)|GBM - Glioblastoma multiforme(13;5.07e-29)|OV - Ovarian serous cystadenocarcinoma(86;1.05e-19)|Colorectal(212;4.54e-07)|COAD - Colon adenocarcinoma(227;3.14e-05)|Kidney(185;0.00012)|BRCA - Breast invasive adenocarcinoma(365;0.00102)|KIRC - Kidney renal clear cell carcinoma(229;0.00179)|STAD - Stomach adenocarcinoma(132;0.00472)|READ - Rectum adenocarcinoma(331;0.0649)		TGGGCTTGACGCGGCCAAACC	0.632000													34	14					0	0	1	0	0
LMBR1	64327	broad.mit.edu	37	7	156518477	156518477	+	Missense_Mutation	SNP	G	G	A			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr7:156518477G>A	ENST00000353442.5	-	13	1284	c.1048C>T	c.(1048-1050)Ctt>Ttt	p.L350F	LMBR1_ENST00000540390.1_Missense_Mutation_p.L329F|LMBR1_ENST00000359422.4_Missense_Mutation_p.L198F|LMBR1_ENST00000354505.4_Missense_Mutation_p.L391F	NM_022458.3	NP_071903.2	Q8WVP7	LMBR1_HUMAN	limb development membrane protein 1							integral to membrane	receptor activity			breast(1)|endometrium(4)|kidney(1)|large_intestine(2)|lung(9)|skin(1)	18	Ovarian(565;0.218)	all_hematologic(28;0.0592)	OV - Ovarian serous cystadenocarcinoma(82;0.00231)	UCEC - Uterine corpus endometrioid carcinoma (81;0.208)		ATGATTTCAAGCGCAGCTCCC	0.398000													39	12					0	0	1	0	0
GFAP	2670	broad.mit.edu	37	17	42992455	42992455	+	Missense_Mutation	SNP	T	T	A			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr17:42992455T>A	ENST00000253408.5	-	1	465	c.400A>T	c.(400-402)Agc>Tgc	p.S134C	GFAP_ENST00000591327.1_5'UTR|GFAP_ENST00000588735.1_Intron|GFAP_ENST00000435360.2_Missense_Mutation_p.S134C|GFAP_ENST00000586793.1_Missense_Mutation_p.S134C	NM_002055.4	NP_002046.1	P14136	GFAP_HUMAN	glial fibrillary acidic protein	134	Coil 1B.|Rod.					cytoplasm|intermediate filament	structural constituent of cytoskeleton			endometrium(3)|kidney(1)|large_intestine(2)|liver(1)|lung(11)|ovary(1)|pancreas(1)|skin(2)|urinary_tract(1)	23		Prostate(33;0.0959)				AGCCGGGCGCTGTTGGCGGTG	0.647000													11	33					0	0	1	0	0
SGPL1	8879	broad.mit.edu	37	10	72633171	72633171	+	Nonsense_Mutation	SNP	C	C	T			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr10:72633171C>T	ENST00000373202.3	+	12	1323	c.1123C>T	c.(1123-1125)Cag>Tag	p.Q375*		NM_003901.3	NP_003892.2	O95470	SGPL1_HUMAN	sphingosine-1-phosphate lyase 1	375					apoptosis|carboxylic acid metabolic process|ceramide metabolic process|sphingolipid catabolic process	integral to endoplasmic reticulum membrane	carboxy-lyase activity|pyridoxal phosphate binding|sphinganine-1-phosphate aldolase activity			large_intestine(4)	4					Pyridoxal Phosphate(DB00114)	CAGGAACTATCAGTTCTTCGT	0.498000													20	62					0	0	1	0	0
UBN2	254048	broad.mit.edu	37	7	138968078	138968078	+	Missense_Mutation	SNP	C	C	G			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr7:138968078C>G	ENST00000473989.3	+	15	2427	c.2427C>G	c.(2425-2427)atC>atG	p.I809M	UBN2_ENST00000288561.8_Missense_Mutation_p.I726M	NM_173569.3	NP_775840.3	Q6ZU65	UBN2_HUMAN	ubinuclein 2											NS(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(5)|large_intestine(7)|lung(16)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(1)	42						TAGCAAGTATCATGAGTAAGC	0.448000													14	55					0	0	1	0	0
ARHGEF7	8874	broad.mit.edu	37	13	111932989	111932989	+	Missense_Mutation	SNP	C	C	T			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr13:111932989C>T	ENST00000375741.2	+	16	2003	c.1753C>T	c.(1753-1755)Ccc>Tcc	p.P585S	ARHGEF7_ENST00000317133.5_Missense_Mutation_p.P564S|ARHGEF7_ENST00000544132.1_3'UTR|ARHGEF7_ENST00000375736.4_Missense_Mutation_p.P407S|ARHGEF7_ENST00000375737.5_Missense_Mutation_p.P482S|ARHGEF7_ENST00000375739.2_Missense_Mutation_p.P535S|ARHGEF7_ENST00000375723.1_Missense_Mutation_p.P407S|ARHGEF7_ENST00000478679.1_Missense_Mutation_p.P329S|ARHGEF7_ENST00000370623.3_Missense_Mutation_p.P492S|ARHGEF7_ENST00000426073.2_Missense_Mutation_p.P407S|ARHGEF7_ENST00000218789.5_Missense_Mutation_p.P407S	NM_001113511.1|NM_145735.2	NP_001106983.1|NP_663788.1	Q14155	ARHG7_HUMAN	Rho guanine nucleotide exchange factor (GEF) 7	585					apoptosis|epidermal growth factor receptor signaling pathway|induction of apoptosis by extracellular signals|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	protein binding|Rho guanyl-nucleotide exchange factor activity			breast(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(9)|lung(16)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|soft_tissue(1)	41	all_lung(23;3.96e-05)|Lung NSC(43;0.00156)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Medulloblastoma(90;0.163)		BRCA - Breast invasive adenocarcinoma(86;0.188)			TGTGGGAAACCCCACCATAAA	0.537000													23	70					0	0	1	0	0
ZP1	22917	broad.mit.edu	37	11	60642428	60642428	+	Missense_Mutation	SNP	C	C	T			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr11:60642428C>T	ENST00000278853.5	+	10	1595	c.1595C>T	c.(1594-1596)tCt>tTt	p.S532F		NM_207341.2	NP_997224.2	P60852	ZP1_HUMAN	zona pellucida glycoprotein 1 (sperm receptor)	532	ZP.				single fertilization	integral to membrane|plasma membrane|proteinaceous extracellular matrix				breast(3)|endometrium(2)|large_intestine(8)|lung(8)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	26						TGCAGCACCTCTGCCTGCCAC	0.527000													28	59					0	0	1	0	0
VIL1	7429	broad.mit.edu	37	2	219289008	219289008	+	Missense_Mutation	SNP	G	G	C			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr2:219289008G>C	ENST00000248444.5	+	3	172	c.84G>C	c.(82-84)caG>caC	p.Q28H	VIL1_ENST00000392114.2_Intron|VIL1_ENST00000440053.1_Missense_Mutation_p.Q28H	NM_007127.2	NP_009058.2	P09327	VILI_HUMAN	villin 1	28	Core.|Necessary for homodimerization.				actin filament capping|actin filament depolymerization|actin filament polymerization|actin filament severing|apoptosis|cellular response to epidermal growth factor stimulus|cytoplasmic actin-based contraction involved in cell motility|epidermal growth factor receptor signaling pathway|positive regulation of actin filament bundle assembly|positive regulation of epithelial cell migration|regulation of actin nucleation|regulation of cell shape|regulation of lamellipodium morphogenesis|regulation of wound healing|response to bacterium	actin filament bundle|cytoplasm|filopodium tip|intracellular membrane-bounded organelle|lamellipodium|microvillus|ruffle	actin filament binding|calcium ion binding|caspase inhibitor activity|lysophosphatidic acid binding|phosphatidylinositol-4,5-bisphosphate binding|protein homodimerization activity			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(20)|ovary(2)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	41		Renal(207;0.0474)		Epithelial(149;6.88e-07)|all cancers(144;0.00013)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		AGGCCATGCAGATGGTGCCTG	0.627000													22	30					0	0	1	0	0
ERCC4	2072	broad.mit.edu	37	16	14029110	14029110	+	Missense_Mutation	SNP	G	G	A			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr16:14029110G>A	ENST00000311895.7	+	8	1330	c.1321G>A	c.(1321-1323)Gag>Aag	p.E441K	CTD-2135D7.2_ENST00000570663.1_RNA|CTD-2135D7.2_ENST00000575137.1_RNA	NM_005236.2	NP_005227.1	Q92889	XPF_HUMAN	excision repair cross-complementing rodent repair deficiency, complementation group 4	441					double-strand break repair via homologous recombination|meiotic mismatch repair|negative regulation of telomere maintenance|nucleotide-excision repair, DNA damage removal|nucleotide-excision repair, DNA incision, 3'-to lesion|nucleotide-excision repair, DNA incision, 5'-to lesion|resolution of meiotic recombination intermediates|telomere maintenance via telomere shortening|transcription-coupled nucleotide-excision repair	nuclear chromosome, telomeric region|nucleoplasm|nucleotide-excision repair factor 1 complex	damaged DNA binding|protein C-terminus binding|protein N-terminus binding|single-stranded DNA binding|single-stranded DNA specific endodeoxyribonuclease activity			NS(1)|breast(1)|endometrium(7)|kidney(3)|large_intestine(5)|lung(12)|ovary(4)|pancreas(1)|prostate(1)|skin(3)	38						GAAAACCTTTGAGAAGGATAG	0.423000			"""Mis, N, F"""			"""skin basal cell, skin squamous cell, melanoma"""		Nucleotide excision repair (NER)	Xeroderma Pigmentosum				47	37					0	0	1	0	0
SUN3	256979	broad.mit.edu	37	7	48026960	48026960	+	Silent	SNP	G	G	A			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr7:48026960G>A	ENST00000453192.2	-	11	1248	c.1005C>T	c.(1003-1005)ttC>ttT	p.F335F	SUN3_ENST00000297325.4_Silent_p.F347F|SUN3_ENST00000473723.1_5'UTR|SUN3_ENST00000395572.2_Silent_p.F347F|SUN3_ENST00000412142.1_Silent_p.F259F	NM_001284350.1	NP_001271279.1	Q8TAQ9	SUN3_HUMAN	Sad1 and UNC84 domain containing 3	347	SUN.					integral to membrane				central_nervous_system(1)|endometrium(3)|large_intestine(8)|liver(1)|lung(15)|upper_aerodigestive_tract(1)|urinary_tract(1)	30						CATGGACCCTGAATCGATATA	0.383000													54	100					0	0	1	0	0
TTYH1	57348	broad.mit.edu	37	19	54942066	54942066	+	Nonsense_Mutation	SNP	C	C	T			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr19:54942066C>T	ENST00000301194.4	+	9	1137	c.1015C>T	c.(1015-1017)Cag>Tag	p.Q339*	TTYH1_ENST00000391739.3_Missense_Mutation_p.S369L|TTYH1_ENST00000376530.3_Nonsense_Mutation_p.Q339*|TTYH1_ENST00000376531.3_Nonsense_Mutation_p.Q339*|TTYH1_ENST00000489425.1_3'UTR|AC008746.3_ENST00000457113.1_RNA			Q9H313	TTYH1_HUMAN	tweety family member 1	339					cell adhesion	chloride channel complex|plasma membrane	chloride channel activity|iron ion transmembrane transporter activity			endometrium(1)|kidney(1)|large_intestine(5)|lung(6)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	17	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.0767)		AGCTGTGCCTCAGTTCCCTTC	0.682000													23	60					0	0	1	0	0
PWP2	5822	broad.mit.edu	37	21	45548015	45548015	+	Silent	SNP	G	G	A			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr21:45548015G>A	ENST00000291576.7	+	18	2470	c.2343G>A	c.(2341-2343)gcG>gcA	p.A781A	PWP2_ENST00000494310.1_3'UTR	NM_005049.2	NP_005040.2	Q15269	PWP2_HUMAN	PWP2 periodic tryptophan protein homolog (yeast)	781						cytoplasm|nucleolus	signal transducer activity			cervix(1)|endometrium(6)|large_intestine(6)|lung(4)|pancreas(1)|prostate(1)|stomach(1)|urinary_tract(1)	21				STAD - Stomach adenocarcinoma(101;0.172)|Colorectal(79;0.2)		CCCTGGAGGCGGTGCCCAGGG	0.632000													16	19					0	0	1	0	0
KIF1A	547	broad.mit.edu	37	2	241725797	241725797	+	Missense_Mutation	SNP	G	G	C			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr2:241725797G>C	ENST00000498729.2	-	6	809	c.563C>G	c.(562-564)tCc>tGc	p.S188C	KIF1A_ENST00000320389.7_Missense_Mutation_p.S188C	NM_001244008.1	NP_001230937.1	Q12756	KIF1A_HUMAN	kinesin family member 1A	188	Kinesin-motor.				anterograde axon cargo transport	cytoplasm|microtubule|nucleus	ATP binding|microtubule motor activity			NS(1)|central_nervous_system(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(8)|lung(25)|ovary(1)|prostate(5)|skin(2)|urinary_tract(1)	66		all_epithelial(40;1.35e-15)|Breast(86;2.14e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0295)|all_neural(83;0.0459)|Lung NSC(271;0.0942)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;6.12e-30)|all cancers(36;3.46e-27)|OV - Ovarian serous cystadenocarcinoma(60;1.38e-14)|Kidney(56;5e-09)|KIRC - Kidney renal clear cell carcinoma(57;5e-08)|BRCA - Breast invasive adenocarcinoma(100;5.87e-06)|Lung(119;0.00209)|LUSC - Lung squamous cell carcinoma(224;0.00902)|Colorectal(34;0.0282)|COAD - Colon adenocarcinoma(134;0.176)		GTCATTGTAGGAGGTGACAGC	0.632000													28	27					0	0	1	0	0
BNC2	54796	broad.mit.edu	37	9	16727860	16727860	+	Missense_Mutation	SNP	C	C	T			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr9:16727860C>T	ENST00000380672.4	-	3	322	c.265G>A	c.(265-267)Gaa>Aaa	p.E89K	BNC2_ENST00000545497.1_Intron|BNC2_ENST00000380667.2_Intron|BNC2_ENST00000380666.2_Missense_Mutation_p.E89K	NM_017637.5	NP_060107.3	Q6ZN30	BNC2_HUMAN	basonuclin 2	89					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	zinc ion binding			NS(2)|breast(3)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(16)|liver(1)|lung(22)|ovary(2)|prostate(1)|skin(1)|urinary_tract(2)	60				GBM - Glioblastoma multiforme(50;9.01e-08)		AACCCTGGTTCAGCCGTAGTC	0.438000													26	61					0	0	1	0	0
PTPRD	5789	broad.mit.edu	37	9	8460493	8460493	+	Missense_Mutation	SNP	C	C	T			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr9:8460493C>T	ENST00000381196.4	-	30	4336	c.3793G>A	c.(3793-3795)Gaa>Aaa	p.E1265K	PTPRD_ENST00000537002.1_Missense_Mutation_p.E851K|PTPRD_ENST00000360074.4_Missense_Mutation_p.E1252K|PTPRD_ENST00000358503.5_Missense_Mutation_p.E1243K|PTPRD_ENST00000397611.3_Missense_Mutation_p.E851K|PTPRD_ENST00000355233.5_Missense_Mutation_p.E854K|PTPRD_ENST00000486161.1_Missense_Mutation_p.E854K|PTPRD_ENST00000397617.3_Missense_Mutation_p.E844K|PTPRD_ENST00000397606.3_Missense_Mutation_p.E844K|PTPRD_ENST00000540109.1_Missense_Mutation_p.E1265K|PTPRD_ENST00000356435.5_Missense_Mutation_p.E1265K	NM_002839.3	NP_002830.1	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	1265					transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(7)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|liver(1)|lung(83)|ovary(4)|pancreas(1)|prostate(7)|skin(19)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	168		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		ATCAAGCCTTCTTCTTCATCC	0.453000										TSP Lung(15;0.13)			17	42					0	0	1	0	0
HSPBAP1	79663	broad.mit.edu	37	3	122478187	122478187	+	Silent	SNP	G	G	A	rs74824564	by1000genomes	TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr3:122478187G>A	ENST00000383659.1	-	4	575	c.453C>T	c.(451-453)ttC>ttT	p.F151F	HSPBAP1_ENST00000465044.1_5'UTR|HSPBAP1_ENST00000306103.2_Silent_p.F151F			Q96EW2	HBAP1_HUMAN	HSPB (heat shock 27kDa) associated protein 1	151	Interaction with HSPB1 (By similarity).|JmjC.					cytoplasm				breast(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(8)|ovary(1)|urinary_tract(1)	16				GBM - Glioblastoma multiforme(114;0.0531)		CAGGAAACCCGAAGTCAGACC	0.438000													66	65					0	0	1	0	0
SLIT3	6586	broad.mit.edu	37	5	168100279	168100279	+	Missense_Mutation	SNP	C	C	G			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr5:168100279C>G	ENST00000519560.1	-	33	4163	c.3744G>C	c.(3742-3744)caG>caC	p.Q1248H	SLIT3_ENST00000332966.8_Missense_Mutation_p.Q1255H|SLIT3_ENST00000404867.3_Missense_Mutation_p.Q1248H	NM_001271946.1|NM_003062.2	NP_001258875.1|NP_003053	O75094	SLIT3_HUMAN	slit homolog 3 (Drosophila)	1248	Laminin G-like.				apoptosis involved in luteolysis|axon extension involved in axon guidance|cellular response to hormone stimulus|negative chemotaxis|negative regulation of cell growth|negative regulation of chemokine-mediated signaling pathway|response to cortisol stimulus|Roundabout signaling pathway	extracellular space|mitochondrion	calcium ion binding|Roundabout binding			endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(15)|liver(2)|lung(48)|ovary(4)|prostate(7)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	100	Renal(175;0.000159)|Lung NSC(126;0.0174)|all_lung(126;0.0392)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			GGTTCAGGGTCTGGTTTAGCG	0.547000													27	59					0	0	1	0	0
WDR92	116143	broad.mit.edu	37	2	68385241	68385241	+	Missense_Mutation	SNP	G	G	T			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr2:68385241G>T	ENST00000406334.3	-	7	667	c.449C>A	c.(448-450)aCg>aAg	p.T150K	PNO1_ENST00000263657.2_Missense_Mutation_p.V59F						0																	GAAGAGGCCCGTCTTCCCACC	0.672000													4	11					0.00116845	0.00117548	1	1	0
RHBDF2	79651	broad.mit.edu	37	17	74470535	74470535	+	Nonsense_Mutation	SNP	G	G	A			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr17:74470535G>A	ENST00000591885.1	-	12	1934	c.1384C>T	c.(1384-1386)Cga>Tga	p.R462*	RHBDF2_ENST00000389760.4_Nonsense_Mutation_p.R462*|RHBDF2_ENST00000313080.4_Nonsense_Mutation_p.R491*			Q6PJF5	RHDF2_HUMAN	rhomboid 5 homolog 2 (Drosophila)	491					negative regulation of protein secretion|protein transport|proteolysis	endoplasmic reticulum membrane|integral to membrane	growth factor binding|serine-type endopeptidase activity			cervix(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(13)|ovary(1)|prostate(4)|skin(1)	27						TCCAGGTCTCGCTCGCGCAGC	0.647000													78	27					0	0	1	0	0
STX2	2054	broad.mit.edu	37	12	131285986	131285986	+	Missense_Mutation	SNP	C	C	T			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr12:131285986C>T	ENST00000261653.6	-	7	677	c.511G>A	c.(511-513)Ggg>Agg	p.G171R	STX2_ENST00000392373.2_Missense_Mutation_p.G171R	NM_001980.3	NP_001971.2	P32856	STX2_HUMAN	syntaxin 2	171					acrosome reaction|ectoderm development|intracellular protein transport|organ morphogenesis|signal transduction	basolateral plasma membrane|integral to membrane|microsome|soluble fraction	calcium-dependent protein binding|SNAP receptor activity	p.G171W(2)		breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(7)|prostate(1)	16	all_neural(191;0.0982)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;2.79e-06)|all cancers(50;5.27e-05)|Epithelial(86;5.29e-05)		GATGGCTTCCCGCTCTCCAGC	0.522000													35	27					0	0	1	0	0
ITIH1	3697	broad.mit.edu	37	3	52822256	52822256	+	Missense_Mutation	SNP	G	G	C			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr3:52822256G>C	ENST00000273283.2	+	18	2038	c.2014G>C	c.(2014-2016)Gac>Cac	p.D672H	ITIH1_ENST00000540715.1_Missense_Mutation_p.D530H|ITIH1_ENST00000405128.3_Missense_Mutation_p.D38H|ITIH1_ENST00000537050.1_Missense_Mutation_p.D384H|ITIH1_ENST00000542827.1_Splice_Site	NM_002215.3	NP_002206.2	P19827	ITIH1_HUMAN	inter-alpha-trypsin inhibitor heavy chain 1	672	Hyaluronan-binding.				hyaluronan metabolic process|leukocyte activation	extracellular region	calcium ion binding|serine-type endopeptidase inhibitor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(16)|lung(18)|ovary(4)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	52				BRCA - Breast invasive adenocarcinoma(193;7.04e-05)|Kidney(197;0.000659)|KIRC - Kidney renal clear cell carcinoma(197;0.000795)|OV - Ovarian serous cystadenocarcinoma(275;0.0498)		AGTGGACACAGACCCTCACTT	0.572000													6	12					0	0	1	0	0
KIF5A	3798	broad.mit.edu	37	12	57965107	57965107	+	Missense_Mutation	SNP	G	G	A			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr12:57965107G>A	ENST00000455537.2	+	13	1571	c.1297G>A	c.(1297-1299)Gat>Aat	p.D433N	KIF5A_ENST00000286452.5_Missense_Mutation_p.D344N	NM_004984.2	NP_004975.2	Q12840	KIF5A_HUMAN	kinesin family member 5A	433					blood coagulation|cell death|microtubule-based movement|synaptic transmission	cytosol|kinesin complex|membrane fraction|microtubule|perinuclear region of cytoplasm	ATP binding|microtubule motor activity			breast(2)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(11)|liver(1)|lung(32)|ovary(2)|prostate(2)|skin(2)	62						CCAACAGGATGATGAAATCAA	0.478000													12	25					0	0	1	0	0
DNAJC6	9829	broad.mit.edu	37	1	65858197	65858197	+	Silent	SNP	C	C	T			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr1:65858197C>T	ENST00000395325.3	+	12	1538	c.1381C>T	c.(1381-1383)Ctg>Ttg	p.L461L	DNAJC6_ENST00000263441.7_Silent_p.L448L|DNAJC6_ENST00000371069.4_Silent_p.L518L	NM_014787.3	NP_055602.1	O75061	AUXI_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 6	461					cellular membrane organization|post-Golgi vesicle-mediated transport	cytosol	heat shock protein binding|protein tyrosine phosphatase activity|SH3 domain binding			NS(1)|breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(22)|ovary(1)|prostate(2)|skin(1)	39						TGATGAACTTCTGACACTTTC	0.527000													5	26					0	0	1	0	0
TEX2	55852	broad.mit.edu	37	17	62290455	62290455	+	Missense_Mutation	SNP	C	C	T			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr17:62290455C>T	ENST00000258991.3	-	2	1207	c.1123G>A	c.(1123-1125)Gag>Aag	p.E375K	TEX2_ENST00000584379.1_Missense_Mutation_p.E375K|TEX2_ENST00000583097.1_Missense_Mutation_p.E375K			Q8IWB9	TEX2_HUMAN	testis expressed 2	375					signal transduction|sphingolipid metabolic process	integral to membrane				breast(3)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(15)|ovary(1)|pancreas(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	41			BRCA - Breast invasive adenocarcinoma(8;1.33e-10)	READ - Rectum adenocarcinoma(1115;0.0689)		CTTGTGGGCTCACCAGTGGAC	0.483000													20	72					0	0	1	0	0
MACF1	23499	broad.mit.edu	37	1	39900203	39900203	+	Missense_Mutation	SNP	G	G	C			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr1:39900203G>C	ENST00000564288.1	+	69	18460	c.17683G>C	c.(17683-17685)Gag>Cag	p.E5895Q	MACF1_ENST00000545844.1_Missense_Mutation_p.E3833Q|MACF1_ENST00000372915.3_Missense_Mutation_p.E5791Q|MACF1_ENST00000361689.2_Missense_Mutation_p.E3833Q|MACF1_ENST00000539005.1_Missense_Mutation_p.E3703Q|MACF1_ENST00000567887.1_Missense_Mutation_p.E5932Q|MACF1_ENST00000289893.4_Missense_Mutation_p.E4335Q|MACF1_ENST00000317713.7_Missense_Mutation_p.E3833Q			Q9UPN3	MACF1_HUMAN	microtubule-actin crosslinking factor 1	5899					cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			breast(11)|central_nervous_system(5)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(36)|lung(78)|ovary(12)|prostate(2)|skin(9)|stomach(2)|upper_aerodigestive_tract(8)|urinary_tract(10)	203	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			AACTTATGAAGAGCTCAGCCC	0.488000													192	31					0	0	1	0	0
PXDN	7837	broad.mit.edu	37	2	1652233	1652233	+	Missense_Mutation	SNP	G	G	A			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr2:1652233G>A	ENST00000252804.4	-	17	3369	c.3319C>T	c.(3319-3321)Cgg>Tgg	p.R1107W		NM_012293.1	NP_036425.1	Q92626	PXDN_HUMAN	peroxidasin homolog (Drosophila)	1107					extracellular matrix organization|hydrogen peroxide catabolic process|immune response	endoplasmic reticulum|extracellular space|proteinaceous extracellular matrix	extracellular matrix structural constituent|heme binding|interleukin-1 receptor antagonist activity|peroxidase activity			breast(1)|cervix(3)|endometrium(10)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(24)|lung(48)|ovary(3)|pancreas(8)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	112	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.0845)|Lung NSC(108;0.00641)|all_epithelial(98;0.00716)		all cancers(51;0.0492)|OV - Ovarian serous cystadenocarcinoma(76;0.0973)|Epithelial(75;0.17)|GBM - Glioblastoma multiforme(21;0.228)		TTCACAATCCGGAAGGGAGAG	0.587000													5	26					0	0	1	0	0
YEATS2	55689	broad.mit.edu	37	3	183528370	183528370	+	Nonstop_Mutation	SNP	G	G	T			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr3:183528370G>T	ENST00000305135.5	+	31	4463	c.4268G>T	c.(4267-4269)tGa>tTa	p.*1423L	YEATS2-AS1_ENST00000609195.1_RNA	NM_018023.4	NP_060493.3	Q9ULM3	YETS2_HUMAN	YEATS domain containing 2	0					histone H3 acetylation|negative regulation of transcription from RNA polymerase II promoter	Ada2/Gcn5/Ada3 transcription activator complex	TBP-class protein binding			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(24)|ovary(3)|prostate(2)|skin(3)	49	all_cancers(143;6.55e-10)|Ovarian(172;0.0303)		all cancers(12;2.38e-42)|Epithelial(37;1.9e-36)|OV - Ovarian serous cystadenocarcinoma(80;6.48e-22)			GAGGACCAGTGAGCGGAGTGA	0.488000													13	35					4.3838e-07	4.52842e-07	1	1	0
DNAH10	196385	broad.mit.edu	37	12	124403231	124403231	+	Missense_Mutation	SNP	G	G	C			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr12:124403231G>C	ENST00000409039.3	+	64	10912	c.10887G>C	c.(10885-10887)gaG>gaC	p.E3629D		NM_207437.3	NP_997320.2	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	3629	AAA 5 (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(14)|ovary(4)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	52	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		AGGTCTCAGAGAAACTCAAGC	0.592000													15	48					0	0	1	0	0
GRB14	2888	broad.mit.edu	37	2	165404260	165404260	+	Missense_Mutation	SNP	G	G	C			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr2:165404260G>C	ENST00000263915.3	-	3	929	c.391C>G	c.(391-393)Cga>Gga	p.R131G	GRB14_ENST00000543549.1_Missense_Mutation_p.R44G	NM_004490.2	NP_004481.2	Q14449	GRB14_HUMAN	growth factor receptor-bound protein 14	131	Ras-associating.				blood coagulation|leukocyte migration	cytosol|endosome membrane|Golgi membrane|microsome|plasma membrane	SH3/SH2 adaptor activity			breast(3)|endometrium(2)|large_intestine(6)|lung(10)|ovary(7)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	32						CAAACATCTCGAGCCGTTATG	0.423000													4	28					0	0	1	0	0
C1orf110	339512	broad.mit.edu	37	1	162824967	162824967	+	Missense_Mutation	SNP	G	G	C			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr1:162824967G>C	ENST00000367912.2	-	4	668	c.494C>G	c.(493-495)tCt>tGt	p.S165C	C1orf110_ENST00000367910.1_Missense_Mutation_p.S166C|C1orf110_ENST00000367911.2_Missense_Mutation_p.S161C|C1orf110_ENST00000524691.1_Intron			Q86UF4	CA110_HUMAN	chromosome 1 open reading frame 110											endometrium(2)|kidney(1)|lung(6)|prostate(1)|skin(2)	12						TACGTCCTTAGATGGATTCAC	0.468000													19	687					0	0	1	0	0
ACPP	55	broad.mit.edu	37	3	132063807	132063807	+	Missense_Mutation	SNP	G	G	A			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr3:132063807G>A	ENST00000336375.5	+	7	775	c.685G>A	c.(685-687)Gag>Aag	p.E229K	ACPP_ENST00000351273.7_Missense_Mutation_p.E229K|ACPP_ENST00000475741.1_Missense_Mutation_p.E196K	NM_001099.4	NP_001090.2	P15309	PPAP_HUMAN	acid phosphatase, prostate	229						extracellular region|lysosomal membrane	5'-nucleotidase activity|acid phosphatase activity			NS(1)|breast(1)|endometrium(2)|large_intestine(5)|lung(13)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	27						CTGGGCCACTGAGGACACCAT	0.413000													16	77					0	0	1	0	0
GON4L	54856	broad.mit.edu	37	1	155790434	155790434	+	Missense_Mutation	SNP	G	G	T			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr1:155790434G>T	ENST00000437809.1	-	6	1099	c.977C>A	c.(976-978)aCa>aAa	p.T326K	GON4L_ENST00000471341.1_5'UTR|GON4L_ENST00000368331.1_Missense_Mutation_p.T326K|GON4L_ENST00000361040.5_Missense_Mutation_p.T326K|GON4L_ENST00000271883.5_Missense_Mutation_p.T326K	NM_001282856.1	NP_001269785.1	Q3T8J9	GON4L_HUMAN	gon-4-like (C. elegans)	326					regulation of transcription, DNA-dependent	cytoplasm|nucleus	DNA binding			NS(2)|breast(4)|cervix(1)|endometrium(7)|kidney(4)|large_intestine(7)|lung(10)|ovary(3)|prostate(3)|skin(2)|stomach(1)|urinary_tract(1)	45	Hepatocellular(266;0.0997)|all_hematologic(923;0.145)|all_neural(408;0.195)					TTTAGAGCGTGTCATTTTAGG	0.378000													11	51					9.31168e-06	9.50133e-06	1	1	0
RIMS2	9699	broad.mit.edu	37	8	105026785	105026785	+	Silent	SNP	C	C	T			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr8:105026785C>T	ENST00000507740.1	+	17	2954	c.2718C>T	c.(2716-2718)gtC>gtT	p.V906V	RIMS2_ENST00000406091.3_Silent_p.V1092V|RIMS2_ENST00000436393.2_Silent_p.V832V|RIMS2_ENST00000262231.10_Silent_p.V931V	NM_014677.4	NP_055492.3	Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	1154	C2 1.				intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			NS(1)|breast(4)|central_nervous_system(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(22)|liver(1)|lung(68)|ovary(6)|pancreas(2)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(10)|urinary_tract(1)	144			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			GTACTCCAGTCGCAGGACGAA	0.423000										HNSCC(12;0.0054)			38	12					0	0	1	0	0
FLG	2312	broad.mit.edu	37	1	152281003	152281003	+	Missense_Mutation	SNP	T	T	C			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr1:152281003T>C	ENST00000368799.1	-	3	6394	c.6359A>G	c.(6358-6360)gAt>gGt	p.D2120G	FLG-AS1_ENST00000420707.1_RNA|FLG-AS1_ENST00000593011.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	2120	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TTGTGCCTGATCATAATGGGA	0.577000									Ichthyosis				106	804					0	0	1	0	0
CACNA1S	779	broad.mit.edu	37	1	201046204	201046204	+	Silent	SNP	G	G	A			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr1:201046204G>A	ENST00000362061.3	-	12	1897	c.1671C>T	c.(1669-1671)cgC>cgT	p.R557R	CACNA1S_ENST00000367338.3_Silent_p.R557R	NM_000069.2	NP_000060.2	Q13698	CAC1S_HUMAN	calcium channel, voltage-dependent, L type, alpha 1S subunit	557					axon guidance	I band|T-tubule|voltage-gated calcium channel complex	high voltage-gated calcium channel activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(13)|large_intestine(19)|lung(37)|ovary(6)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	102					Magnesium Sulfate(DB00653)|Verapamil(DB00661)	AGGCGATGGAGCGGATGGAGT	0.577000													88	10					0	0	1	0	0
GPR162	27239	broad.mit.edu	37	12	6935872	6935872	+	Missense_Mutation	SNP	C	C	G			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr12:6935872C>G	ENST00000311268.3	+	5	2057	c.1270C>G	c.(1270-1272)Cgg>Ggg	p.R424G	GPR162_ENST00000428545.2_Missense_Mutation_p.R140G|GPR162_ENST00000382315.3_Missense_Mutation_p.R120G	NM_019858.1	NP_062832.1	Q16538	GP162_HUMAN	G protein-coupled receptor 162	424						integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(5)|ovary(2)|pancreas(2)|skin(1)	18						CTCTACCCCTCGGGAACCAGG	0.622000													34	126					0	0	1	0	0
ZNF511	118472	broad.mit.edu	37	10	135164890	135164890	+	Silent	SNP	T	T	C			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr10:135164890T>C	ENST00000368554.4	+	6	580	c.558T>C	c.(556-558)ccT>ccC	p.P186P	PRAP1_ENST00000458230.1_Silent_p.P27P|PRAP1_ENST00000463201.1_3'UTR|PRAP1_ENST00000433452.2_Silent_p.P27P|PRAP1_ENST00000423766.1_Silent_p.P27P			Q8NB15	ZN511_HUMAN	zinc finger protein 511	0					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			cervix(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(2)|ovary(1)	8		all_cancers(35;7.01e-07)|all_epithelial(44;1.45e-05)|Lung NSC(174;0.027)|all_lung(145;0.0384)|all_neural(114;0.0726)|Glioma(114;0.172)|Melanoma(40;0.175)		all cancers(32;7.56e-06)|OV - Ovarian serous cystadenocarcinoma(35;8.15e-06)|Epithelial(32;9.99e-06)		CCCAGGTCCCTATCAAGATGC	0.637000													7	12					0	0	1	0	0
ZNF616	90317	broad.mit.edu	37	19	52618466	52618466	+	Missense_Mutation	SNP	G	G	T			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr19:52618466G>T	ENST00000600228.1	-	4	2212	c.1951C>A	c.(1951-1953)Cat>Aat	p.H651N	ZNF616_ENST00000330123.5_3'UTR	NM_178523.3	NP_848618.2	Q08AN1	ZN616_HUMAN	zinc finger protein 616	651					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(4)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(14)|lung(14)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	48				GBM - Glioblastoma multiforme(134;0.00392)|OV - Ovarian serous cystadenocarcinoma(262;0.0189)		ACAGTCTGATGAAGTCTAAGA	0.418000													43	38					3.76604e-16	4.0576e-16	1	1	0
ATXN7L1	222255	broad.mit.edu	37	7	105401857	105401857	+	Silent	SNP	C	C	T			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr7:105401857C>T	ENST00000318724.4	-	4	431	c.408G>A	c.(406-408)gaG>gaA	p.E136E	ATXN7L1_ENST00000419735.3_Intron|ATXN7L1_ENST00000478915.1_Silent_p.E85E	NM_152749.3	NP_689962.1	Q9ULK2	AT7L1_HUMAN	ataxin 7-like 1	136										endometrium(1)|large_intestine(4)|lung(5)	10						CTTGGCTGCTCTCTGGTCCAC	0.458000													90	26					0	0	1	0	0
BCL3	602	broad.mit.edu	37	19	45259496	45259496	+	Missense_Mutation	SNP	C	C	T			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr19:45259496C>T	ENST00000164227.5	+	3	662	c.418C>T	c.(418-420)Cat>Tat	p.H140Y		NM_005178.4	NP_005169.2	P20749	BCL3_HUMAN	B-cell CLL/lymphoma 3	140					DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|I-kappaB kinase/NF-kappaB cascade|maintenance of protein location in nucleus|negative regulation of apoptosis|negative regulation of interleukin-8 biosynthetic process|negative regulation of transcription, DNA-dependent|positive regulation of translation|protein import into nucleus, translocation|regulation of DNA binding|regulation of NF-kappaB import into nucleus|response to UV-C|response to virus	Bcl3-Bcl10 complex|Bcl3/NF-kappaB2 complex|nucleus|perinuclear region of cytoplasm	protein binding, bridging|transcription factor binding			kidney(1)|large_intestine(2)|lung(2)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	10	Lung NSC(12;0.000698)|all_lung(12;0.002)	Ovarian(192;0.0728)				CAGGCCTCTCCATATTGCTGT	0.567000			T	IGH@	CLL								9	18					0	0	1	0	0
UBN2	254048	broad.mit.edu	37	7	138968631	138968631	+	Missense_Mutation	SNP	C	C	G			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr7:138968631C>G	ENST00000473989.3	+	15	2980	c.2980C>G	c.(2980-2982)Caa>Gaa	p.Q994E	UBN2_ENST00000288561.8_Missense_Mutation_p.Q911E	NM_173569.3	NP_775840.3	Q6ZU65	UBN2_HUMAN	ubinuclein 2		Ser-rich.							p.Q911E(1)		NS(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(5)|large_intestine(7)|lung(16)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(1)	42						AAATGGTTCTCAAGGGTCCCA	0.493000													16	53					0	0	1	0	0
ZNF454	285676	broad.mit.edu	37	5	178391770	178391770	+	Missense_Mutation	SNP	G	G	A			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr5:178391770G>A	ENST00000320129.3	+	5	668	c.365G>A	c.(364-366)tGt>tAt	p.C122Y	ZNF454_ENST00000519564.1_Missense_Mutation_p.C122Y	NM_001178090.1|NM_182594.2	NP_001171561.1|NP_872400.2	Q8N9F8	ZN454_HUMAN	zinc finger protein 454	122					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(2)|large_intestine(11)|lung(18)|ovary(2)|prostate(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(2)	46	all_cancers(89;0.000904)|Renal(175;0.000159)|all_epithelial(37;0.000167)|Lung NSC(126;0.00199)|all_lung(126;0.00351)	all_cancers(40;0.225)|all_neural(177;0.00802)|Medulloblastoma(196;0.0145)|all_hematologic(541;0.248)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.234)		CACTGGAAGTGTGCTAGCCTG	0.483000													11	31					0	0	1	0	0
BOD1L1	259282	broad.mit.edu	37	4	13601435	13601435	+	Silent	SNP	C	C	T			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr4:13601435C>T	ENST00000040738.5	-	10	7224	c.7089G>A	c.(7087-7089)ctG>ctA	p.L2363L		NM_148894.2	NP_683692.2	Q8NFC6	BOD1L_HUMAN	biorientation of chromosomes in cell division 1-like 1	2363							DNA binding										CTGTGGCTGACAGGTCACCGT	0.542000													26	40					0	0	1	0	0
SAMD3	154075	broad.mit.edu	37	6	130497110	130497110	+	Missense_Mutation	SNP	C	C	T			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr6:130497110C>T	ENST00000532763.1	-	7	821	c.692G>A	c.(691-693)cGa>cAa	p.R231Q	SAMD3_ENST00000437477.2_Missense_Mutation_p.R233Q|SAMD3_ENST00000368134.2_Missense_Mutation_p.R233Q|SAMD3_ENST00000533296.1_5'UTR|SAMD3_ENST00000457563.2_Missense_Mutation_p.R257Q|SAMD3_ENST00000439090.2_Missense_Mutation_p.R233Q			Q8N6K7	SAMD3_HUMAN	sterile alpha motif domain containing 3	233										breast(1)|central_nervous_system(1)|kidney(2)|large_intestine(3)|lung(15)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	29				GBM - Glioblastoma multiforme(226;0.00594)|OV - Ovarian serous cystadenocarcinoma(155;0.128)		TATGGGTCTTCGAACATATTT	0.343000													23	18					0	0	1	0	0
ZFHX3	463	broad.mit.edu	37	16	72821615	72821615	+	Silent	SNP	G	G	A			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr16:72821615G>A	ENST00000268489.5	-	10	11232	c.10560C>T	c.(10558-10560)ggC>ggT	p.G3520G	AC004943.1_ENST00000584072.1_RNA|ZFHX3_ENST00000397992.5_Silent_p.G2606G	NM_006885.3	NP_008816.3	Q15911	ZFHX3_HUMAN	zinc finger homeobox 3	3520	Poly-Gly.				muscle organ development|negative regulation of myoblast differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|positive regulation of myoblast differentiation	transcription factor complex	enzyme binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			NS(3)|breast(7)|cervix(2)|endometrium(18)|haematopoietic_and_lymphoid_tissue(5)|kidney(8)|large_intestine(22)|liver(1)|lung(46)|ovary(5)|pancreas(1)|prostate(15)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(11)	153		Ovarian(137;0.13)				cgccgccgccgccaccgccgc	0.706000													5	45					0	0	1	0	0
TPCN1	53373	broad.mit.edu	37	12	113664754	113664754	+	Missense_Mutation	SNP	G	G	C			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr12:113664754G>C	ENST00000550785.1	+	3	482	c.313G>C	c.(313-315)Gag>Cag	p.E105Q	TPCN1_ENST00000335509.6_Missense_Mutation_p.E33Q|TPCN1_ENST00000541517.1_Missense_Mutation_p.E105Q	NM_001143819.1	NP_001137291.1	Q9ULQ1	TPC1_HUMAN	two pore segment channel 1	33						endosome membrane|integral to membrane|lysosomal membrane	NAADP-sensitive calcium-release channel activity|voltage-gated ion channel activity			cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(16)|ovary(2)|prostate(3)|skin(3)|urinary_tract(1)	40						GGGCCAAGAAGAGCTACCTAG	0.567000													18	24					0	0	1	0	0
SNHG10	283596	broad.mit.edu	37	14	95999806	95999806	+	RNA	SNP	C	C	T			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr14:95999806C>T	ENST00000500370.2	-	0	766				SCARNA13_ENST00000516672.1_RNA|SNHG10_ENST00000555866.1_RNA|SNHG10_ENST00000554169.1_RNA|SNHG10_ENST00000553559.1_RNA																							CAGTCATTATCACCGTGGCAA	0.448000													73	19					0	0	1	0	0
ESRP2	80004	broad.mit.edu	37	16	68269602	68269602	+	Missense_Mutation	SNP	C	C	G			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr16:68269602C>G	ENST00000473183.2	-	2	800	c.262G>C	c.(262-264)Gag>Cag	p.E88Q	ESRP2_ENST00000565858.1_Missense_Mutation_p.E88Q			Q9H6T0	ESRP2_HUMAN	epithelial splicing regulatory protein 2	88					mRNA processing|regulation of RNA splicing|RNA splicing	nucleus	mRNA binding|nucleotide binding			NS(1)|central_nervous_system(1)|kidney(2)|large_intestine(4)|lung(5)|ovary(1)|prostate(2)	16						CCGCTCGCCTCGCGGCACTGC	0.726000													12	15					0	0	1	0	0
CDKN2AIPNL	91368	broad.mit.edu	37	5	133745644	133745644	+	Missense_Mutation	SNP	C	C	G			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr5:133745644C>G	ENST00000458198.2	-	2	332	c.289G>C	c.(289-291)Gaa>Caa	p.E97Q		NM_080656.2	NP_542387.1	Q96HQ2	C2AIL_HUMAN	CDKN2A interacting protein N-terminal like	97										central_nervous_system(1)|kidney(2)|prostate(1)	4			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			TCTTCCACTTCAATCCCATCG	0.368000													19	21					0	0	1	0	0
TAPT1	202018	broad.mit.edu	37	4	16165044	16165044	+	Missense_Mutation	SNP	C	C	T			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr4:16165044C>T	ENST00000405303.2	-	14	1674	c.1591G>A	c.(1591-1593)Gat>Aat	p.D531N	TAPT1_ENST00000304584.8_3'UTR|TAPT1_ENST00000399920.3_Missense_Mutation_p.D420N	NM_153365.2	NP_699196.2	Q6NXT6	TAPT1_HUMAN	transmembrane anterior posterior transformation 1	531						integral to membrane	growth hormone-releasing hormone receptor activity			NS(1)|breast(2)|cervix(1)|kidney(2)|large_intestine(2)|lung(1)|prostate(1)	10						TCGTCACCATCTGGAGTTGTC	0.373000													28	82					0	0	1	0	0
C9orf24	84688	broad.mit.edu	37	9	34385778	34385778	+	Splice_Site	SNP	C	C	T			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr9:34385778C>T	ENST00000297623.2	-	2	335	c.137G>A	c.(136-138)gGt>gAt	p.G46D		NM_032596.3	NP_115985.2	Q8NCR6	CI024_HUMAN	chromosome 9 open reading frame 24	46										endometrium(1)|kidney(1)|large_intestine(1)|lung(1)|ovary(1)	5			LUSC - Lung squamous cell carcinoma(29;0.0107)	GBM - Glioblastoma multiforme(74;0.123)		ATGAGTCAGACCCTGGGCAAG	0.567000													22	65					0	0	1	0	0
RAD54L2	23132	broad.mit.edu	37	3	51667674	51667674	+	Silent	SNP	C	C	T			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr3:51667674C>T	ENST00000409535.2	+	7	1032	c.907C>T	c.(907-909)Ctg>Ttg	p.L303L	RAD54L2_ENST00000296477.3_5'UTR	NM_015106.2	NP_055921.2	Q9Y4B4	ARIP4_HUMAN	RAD54-like 2 (S. cerevisiae)		Helicase ATP-binding.					nucleus	ATP binding|DNA binding|helicase activity			NS(2)|breast(1)|cervix(2)|endometrium(4)|large_intestine(5)|liver(2)|lung(9)|ovary(4)|skin(2)	31				BRCA - Breast invasive adenocarcinoma(193;0.000102)|Kidney(197;0.000758)|KIRC - Kidney renal clear cell carcinoma(197;0.000896)		TGGCTGTATTCTGGCCCACAG	0.522000													67	57					0	0	1	0	0
PLCD1	5333	broad.mit.edu	37	3	38058157	38058157	+	Missense_Mutation	SNP	C	C	G			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr3:38058157C>G	ENST00000463876.1	-	3	669	c.316G>C	c.(316-318)Gag>Cag	p.E106Q	PLCD1_ENST00000479619.1_5'UTR|PLCD1_ENST00000334661.4_Missense_Mutation_p.E85Q	NM_001130964.1	NP_001124436.1	P51178	PLCD1_HUMAN	phospholipase C, delta 1	85	PH.				intracellular signal transduction|lipid catabolic process|phospholipid metabolic process	cytoplasm	calcium ion binding|GTPase activating protein binding|phosphatidylinositol phospholipase C activity|signal transducer activity			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(6)|lung(6)|prostate(1)|skin(1)	24				KIRC - Kidney renal clear cell carcinoma(284;0.0519)|Kidney(284;0.0653)		GCGAACTTCTCCAGACCCTCC	0.602000													3	15					0	0	1	0	0
TALDO1	6888	broad.mit.edu	37	11	763351	763351	+	Missense_Mutation	SNP	G	G	A	rs140952110		TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr11:763351G>A	ENST00000319006.3	+	5	622	c.469G>A	c.(469-471)Gag>Aag	p.E157K	TALDO1_ENST00000528097.1_Missense_Mutation_p.E157K			P37837	TALDO_HUMAN	transaldolase 1	157					energy reserve metabolic process|xylulose biosynthetic process	cytosol	protein binding|sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glyceronetransferase activity			breast(1)|kidney(2)|large_intestine(5)|lung(4)|prostate(2)	14		all_cancers(49;1.13e-08)|all_epithelial(84;2.95e-05)|Breast(177;0.000286)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.159)|all_lung(207;0.198)		all cancers(45;4.66e-26)|Epithelial(43;2.97e-25)|OV - Ovarian serous cystadenocarcinoma(40;1.48e-19)|BRCA - Breast invasive adenocarcinoma(625;4.41e-05)|Lung(200;0.0595)|LUSC - Lung squamous cell carcinoma(625;0.0712)		CAGGGAGCTCGAGGAGCAGCA	0.697000													26	12					0	0	1	0	0
SEZ6	124925	broad.mit.edu	37	17	27282970	27282970	+	Missense_Mutation	SNP	G	G	C			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr17:27282970G>C	ENST00000360295.9	-	17	3254	c.2979C>G	c.(2977-2979)atC>atG	p.I993M	SEZ6_ENST00000317338.12_3'UTR|SEZ6_ENST00000442608.3_Missense_Mutation_p.I980M|PIPOX_ENST00000583215.1_Intron	NM_001098635.1|NM_178860.4	NP_001092105.1|NP_849191.3	Q53EL9	SEZ6_HUMAN	seizure related 6 homolog (mouse)	0						integral to membrane|plasma membrane				breast(1)|central_nervous_system(1)|endometrium(4)|kidney(4)|large_intestine(4)|lung(11)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	29	Lung NSC(42;0.0137)		Epithelial(11;4.73e-06)|all cancers(11;2.91e-05)|BRCA - Breast invasive adenocarcinoma(11;8.06e-05)|OV - Ovarian serous cystadenocarcinoma(11;0.111)			CCCCCACCTAGATGGAGACTT	0.512000													5	24					0	0	1	0	0
PYGM	5837	broad.mit.edu	37	11	64519937	64519937	+	Missense_Mutation	SNP	G	G	A			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr11:64519937G>A	ENST00000164139.3	-	13	1956	c.1558C>T	c.(1558-1560)Cgc>Tgc	p.R520C	PYGM_ENST00000377432.3_Missense_Mutation_p.R432C	NM_005609.2	NP_005600.1	P11217	PYGM_HUMAN	phosphorylase, glycogen, muscle	520					glucose metabolic process|glycogen catabolic process	cytosol	glycogen phosphorylase activity|protein binding			cervix(1)|endometrium(2)|kidney(3)|large_intestine(4)|lung(21)|ovary(3)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	38					Pyridoxal Phosphate(DB00114)	AGCAGTTTGCGCAGCTGGTCC	0.562000													25	19					0	0	1	0	0
BTBD8	284697	broad.mit.edu	37	1	92568029	92568029	+	Splice_Site	SNP	G	G	C			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr1:92568029G>C	ENST00000370382.3	+	3	614		c.e3-1		BTBD8_ENST00000342818.3_Splice_Site|BTBD8_ENST00000540648.1_Splice_Site			Q5XKL5	BTBD8_HUMAN	BTB (POZ) domain containing 8							nucleus				breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(1)|lung(8)|ovary(1)	16		all_lung(203;0.0484)|Lung NSC(277;0.126)|Glioma(108;0.222)		all cancers(265;0.0153)|Epithelial(280;0.0982)		ttGTCTTTTAGGATTATATAT	0.249000													26	9					0	0	1	0	0
CROCC	9696	broad.mit.edu	37	1	17296403	17296403	+	Missense_Mutation	SNP	G	G	A	rs141836294		TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr1:17296403G>A	ENST00000375541.5	+	33	5494	c.5425G>A	c.(5425-5427)Gag>Aag	p.E1809K		NM_014675.3	NP_055490.3	Q5TZA2	CROCC_HUMAN	ciliary rootlet coiled-coil, rootletin	1809					cell cycle|cell projection organization|centrosome organization|protein localization	actin cytoskeleton|centriole|ciliary rootlet|plasma membrane	kinesin binding|structural molecule activity			breast(3)|central_nervous_system(2)|cervix(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(12)|large_intestine(1)|lung(20)|ovary(3)|prostate(9)|skin(3)|urinary_tract(1)	62		Colorectal(325;3.46e-05)|Breast(348;0.000162)|Lung NSC(340;0.000174)|all_lung(284;0.000234)|Renal(390;0.000518)|Ovarian(437;0.00669)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.63e-06)|COAD - Colon adenocarcinoma(227;1.07e-05)|Kidney(64;0.000163)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.181)		GGTGGAGGCCGAGGGCCAGCT	0.657000													18	47					0	0	1	0	0
RGPD8	727851	broad.mit.edu	37	2	113147101	113147101	+	Missense_Mutation	SNP	C	C	T			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr2:113147101C>T	ENST00000302558.3	-	20	3612	c.3421G>A	c.(3421-3423)Gcc>Acc	p.A1141T	RGPD8_ENST00000409750.1_Missense_Mutation_p.A1001T	NM_001164463.1	NP_001157935.1			RANBP2-like and GRIP domain containing 8											endometrium(4)|kidney(1)|lung(1)|prostate(3)|urinary_tract(1)	10						TCTAGTTTGGCATCACCATCA	0.458000													41	242					0	0	1	0	0
JAM3	83700	broad.mit.edu	37	11	134018532	134018532	+	Missense_Mutation	SNP	G	G	A			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr11:134018532G>A	ENST00000299106.4	+	7	962	c.803G>A	c.(802-804)aGa>aAa	p.R268K	JAM3_ENST00000529443.2_Missense_Mutation_p.R313K|JAM3_ENST00000441717.3_Missense_Mutation_p.R217K			Q9BX67	JAM3_HUMAN	junctional adhesion molecule 3	268					angiogenesis|blood coagulation|regulation of neutrophil chemotaxis	cell-cell contact zone|desmosome|extracellular space|integral to membrane	integrin binding			breast(1)|endometrium(1)|large_intestine(3)|lung(3)|ovary(1)|pancreas(1)	10	all_hematologic(175;0.127)	all_cancers(12;1.06e-21)|all_epithelial(12;3.37e-16)|all_lung(97;7.03e-06)|Lung NSC(97;1.67e-05)|Breast(109;0.000182)|Medulloblastoma(222;0.0245)|all_neural(223;0.0506)|Esophageal squamous(93;0.0566)		Epithelial(10;1.55e-09)|BRCA - Breast invasive adenocarcinoma(10;1.35e-08)|all cancers(11;2.81e-08)|OV - Ovarian serous cystadenocarcinoma(99;0.00402)|Lung(977;0.245)		TGTGCATACAGACGTGGCTAC	0.458000													11	35					0	0	1	0	0
SYCE2	256126	broad.mit.edu	37	19	13029073	13029073	+	Nonsense_Mutation	SNP	C	C	A			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr19:13029073C>A	ENST00000293695.7	-	2	112	c.94G>T	c.(94-96)Gag>Tag	p.E32*		NM_001105578.1	NP_001099048.1	Q6PIF2	SYCE2_HUMAN	synaptonemal complex central element protein 2	32					cell division	central element				endometrium(1)|kidney(1)|large_intestine(2)|lung(3)|urinary_tract(1)	8						TCGCAGTTCTCTTCCCACCGC	0.602000													31	51					3.03874e-20	3.31679e-20	1	1	0
ABCC4	10257	broad.mit.edu	37	13	95815870	95815870	+	Nonsense_Mutation	SNP	G	G	T			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr13:95815870G>T	ENST00000376887.4	-	17	2321	c.2207C>A	c.(2206-2208)tCa>tAa	p.S736*	ABCC4_ENST00000431522.1_Nonsense_Mutation_p.S736*|ABCC4_ENST00000536256.1_Nonsense_Mutation_p.S661*|ABCC4_ENST00000412704.1_Nonsense_Mutation_p.S689*	NM_005845.3	NP_005836.2	O15439	MRP4_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 4	736	ABC transmembrane type-1 2.				platelet activation|platelet degranulation	integral to membrane|membrane fraction|plasma membrane|platelet dense granule membrane	15-hydroxyprostaglandin dehydrogenase (NAD+) activity|ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|chloride channel activity			breast(1)|central_nervous_system(4)|endometrium(5)|kidney(4)|large_intestine(9)|lung(13)|ovary(1)|prostate(1)|skin(4)|urinary_tract(1)	43	all_neural(89;0.0878)|Medulloblastoma(90;0.163)				Cefazolin(DB01327)	TTACCAGTATGAAAGCCACCA	0.393000													4	29					2.56e-06	2.6282e-06	1	1	0
KLC2	64837	broad.mit.edu	37	11	66033221	66033221	+	Missense_Mutation	SNP	G	G	A			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr11:66033221G>A	ENST00000394065.2	+	10	2031	c.1013G>A	c.(1012-1014)cGt>cAt	p.R338H	KLC2_ENST00000394066.2_Missense_Mutation_p.R400H|KLC2_ENST00000394078.1_Intron|KLC2_ENST00000417856.1_Missense_Mutation_p.R477H|KLC2_ENST00000421552.1_Missense_Mutation_p.R400H|KLC2_ENST00000316924.5_Missense_Mutation_p.R477H|KLC2_ENST00000394067.2_Missense_Mutation_p.R477H			Q9H0B6	KLC2_HUMAN	kinesin light chain 2	477					blood coagulation	cytosol|kinesin complex|microtubule	microtubule motor activity|protein binding			breast(2)|endometrium(1)|kidney(1)|large_intestine(7)|lung(3)|prostate(5)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	24						TGTGCCAGCCGTAACCGCAAG	0.667000													3	32					0	0	1	0	0
ETV3L	440695	broad.mit.edu	37	1	157068627	157068627	+	Missense_Mutation	SNP	G	G	C			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr1:157068627G>C	ENST00000454449.2	-	3	641	c.357C>G	c.(355-357)ttC>ttG	p.F119L		NM_001004341.2	NP_001004341.1	Q6ZN32	ETV3L_HUMAN	ets variant 3-like	119						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(9)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	24	Hepatocellular(266;0.158)	Prostate(1639;0.184)				TGCTGAAGTTGAACTTGTATG	0.517000													31	147					0	0	1	0	0
ACCS	84680	broad.mit.edu	37	11	44105036	44105036	+	Silent	SNP	G	G	A			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr11:44105036G>A	ENST00000263776.8	+	14	1751	c.1317G>A	c.(1315-1317)aaG>aaA	p.K439K		NM_001127219.1|NM_032592.3	NP_001120691.1|NP_115981.1	Q96QU6	1A1L1_HUMAN	1-aminocyclopropane-1-carboxylate synthase homolog (Arabidopsis)(non-functional)	439							1-aminocyclopropane-1-carboxylate synthase activity|protein homodimerization activity|pyridoxal phosphate binding|transferase activity, transferring nitrogenous groups			breast(4)|endometrium(3)|large_intestine(11)|lung(15)|ovary(1)|skin(1)	35						TGGACAACAAGGTGCTGCTGT	0.572000													24	7					0	0	1	0	0
GFPT2	9945	broad.mit.edu	37	5	179743770	179743770	+	Silent	SNP	G	G	A			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr5:179743770G>A	ENST00000253778.8	-	12	1315	c.1146C>T	c.(1144-1146)gcC>gcT	p.A382A	GFPT2_ENST00000520165.1_5'UTR	NM_005110.2	NP_005101.1	O94808	GFPT2_HUMAN	glutamine-fructose-6-phosphate transaminase 2	382	SIS 1.				dolichol-linked oligosaccharide biosynthetic process|energy reserve metabolic process|fructose 6-phosphate metabolic process|glutamine metabolic process|post-translational protein modification|protein N-linked glycosylation via asparagine|UDP-N-acetylglucosamine biosynthetic process	cytosol	glutamine-fructose-6-phosphate transaminase (isomerizing) activity|sugar binding			breast(1)|central_nervous_system(2)|kidney(2)|large_intestine(9)|lung(12)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	34	all_cancers(89;4.97e-05)|all_epithelial(37;1.22e-05)|Renal(175;0.000269)|Lung NSC(126;0.00199)|all_lung(126;0.00351)|Breast(19;0.137)	Medulloblastoma(196;0.0392)|all_neural(177;0.0529)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)		L-Glutamine(DB00130)	TTACAGCCACGGCAGCGTGGT	0.562000													8	18					0	0	1	0	0
PHF21A	51317	broad.mit.edu	37	11	45955620	45955620	+	Missense_Mutation	SNP	C	C	T			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr11:45955620C>T	ENST00000257821.4	-	18	2568	c.1945G>A	c.(1945-1947)Gac>Aac	p.D649N	PHF21A_ENST00000418153.2_Missense_Mutation_p.D648N|PHF21A_ENST00000323180.6_Missense_Mutation_p.D602N	NM_001101802.1	NP_001095272.1	Q96BD5	PF21A_HUMAN	PHD finger protein 21A	648	Required for transcriptional repression.				blood coagulation|chromatin modification|negative regulation of transcription from RNA polymerase II promoter|regulation of transcription, DNA-dependent|transcription, DNA-dependent	histone deacetylase complex	DNA binding|zinc ion binding			central_nervous_system(2)|cervix(1)|endometrium(3)|large_intestine(10)|lung(9)|skin(2)|upper_aerodigestive_tract(2)	29						GGGGTGCAGTCCGGGCCATTG	0.612000													9	22					0	0	1	0	0
PAX9	5083	broad.mit.edu	37	14	37132243	37132243	+	Missense_Mutation	SNP	C	C	T			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr14:37132243C>T	ENST00000361487.6	+	2	371	c.146C>T	c.(145-147)tCg>tTg	p.S49L	PAX9_ENST00000402703.2_Missense_Mutation_p.S49L|PAX9_ENST00000554201.1_5'UTR			P55771	PAX9_HUMAN	paired box 9	49	Paired.				multicellular organismal development|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|ovary(1)|upper_aerodigestive_tract(3)	12	Hepatocellular(127;0.158)|Esophageal squamous(585;0.164)|Breast(36;0.218)		Lung(8;1.12e-09)|LUAD - Lung adenocarcinoma(9;2.16e-07)|Epithelial(34;0.00357)|all cancers(34;0.00998)|LUSC - Lung squamous cell carcinoma(13;0.0189)	GBM - Glioblastoma multiforme(112;0.0181)		CTACGGGTCTCGCACGGCTGC	0.667000													53	9					0	0	1	0	0
PCDHGA2	56113	broad.mit.edu	37	5	140719896	140719896	+	Missense_Mutation	SNP	C	C	A			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr5:140719896C>A	ENST00000394576.2	+	1	1358	c.1358C>A	c.(1357-1359)tCc>tAc	p.S453Y	PCDHGA1_ENST00000517417.1_Intron	NM_018915.2	NP_061738.1														breast(3)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(20)|lung(32)|ovary(1)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	77			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCCGCCTTCTCCCGCACATCC	0.557000													27	87					7.41945e-09	7.76022e-09	1	1	0
ATM	472	broad.mit.edu	37	11	108198472	108198472	+	Missense_Mutation	SNP	C	C	A			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr11:108198472C>A	ENST00000278616.4	+	48	7461	c.7076C>A	c.(7075-7077)aCc>aAc	p.T2359N	C11orf65_ENST00000525729.1_Intron|ATM_ENST00000452508.2_Missense_Mutation_p.T2359N	NM_000051.3	NP_000042	Q13315	ATM_HUMAN	ataxia telangiectasia mutated	2359	FAT.				cell cycle arrest|cellular response to gamma radiation|DNA damage induced protein phosphorylation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|double-strand break repair via homologous recombination|G2/M transition DNA damage checkpoint|histone mRNA catabolic process|mitotic cell cycle spindle assembly checkpoint|negative regulation of B cell proliferation|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|pre-B cell allelic exclusion|protein autophosphorylation|reciprocal meiotic recombination|replicative senescence	cytoplasmic membrane-bounded vesicle|nucleoplasm	1-phosphatidylinositol-3-kinase activity|ATP binding|DNA binding|DNA-dependent protein kinase activity|identical protein binding|protein complex binding|protein dimerization activity|protein N-terminus binding			NS(4)|breast(23)|central_nervous_system(11)|endometrium(10)|haematopoietic_and_lymphoid_tissue(227)|kidney(19)|large_intestine(53)|liver(5)|lung(62)|ovary(6)|pancreas(4)|prostate(13)|skin(4)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	448		all_cancers(61;9.64e-12)|all_epithelial(67;9.97e-08)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		Epithelial(105;9.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.06e-05)|all cancers(92;0.000208)|Colorectal(284;0.116)|OV - Ovarian serous cystadenocarcinoma(223;0.147)		ATCATGCAGACCTATCTAGAA	0.378000			"""D, Mis, N, F, S"""		T-PLL	"""leukemia, lymphoma, medulloblastoma, glioma"""		Genes defective in diseases associated with sensitivity to DNA damaging agents	Ataxia Telangiectasia	TSP Lung(14;0.12)			11	33					6.71089e-19	7.27739e-19	1	1	0
WIPF1	7456	broad.mit.edu	37	2	175446123	175446123	+	Silent	SNP	C	C	G			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr2:175446123C>G	ENST00000392547.2	-	3	195	c.96G>C	c.(94-96)ggG>ggC	p.G32G	AC018890.6_ENST00000412835.1_RNA|AC018890.6_ENST00000442996.1_RNA|WIPF1_ENST00000409891.1_Silent_p.G32G|WIPF1_ENST00000272746.5_Silent_p.G32G|WIPF1_ENST00000410117.1_Silent_p.G32G|WIPF1_ENST00000392546.2_Silent_p.G32G|WIPF1_ENST00000409415.3_Silent_p.G32G|WIPF1_ENST00000359761.3_Silent_p.G32G|AC010894.5_ENST00000454203.1_RNA	NM_003387.4	NP_003378.3	O43516	WIPF1_HUMAN	WAS/WASL interacting protein family, member 1	32	WH2.				actin polymerization or depolymerization|protein complex assembly	cytoplasmic membrane-bounded vesicle	actin binding|profilin binding			NS(1)|breast(1)|endometrium(5)|large_intestine(7)|lung(15)|ovary(2)|skin(1)	32						GAGCATTTCTCCCAGCCTGCT	0.423000													29	99					0	0	1	0	0
SPATA31D1	389763	broad.mit.edu	37	9	84608319	84608319	+	Silent	SNP	C	C	T			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr9:84608319C>T	ENST00000344803.2	+	4	2981	c.2934C>T	c.(2932-2934)agC>agT	p.S978S		NM_001001670.2	NP_001001670.1			SPATA31 subfamily D, member 1																		GAACAACAAGCTCAGTCCCCA	0.517000													27	112					0	0	1	0	0
BIRC6	57448	broad.mit.edu	37	2	32733070	32733070	+	Missense_Mutation	SNP	G	G	A			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr2:32733070G>A	ENST00000421745.2	+	51	9858	c.9724G>A	c.(9724-9726)Gaa>Aaa	p.E3242K		NM_016252.3	NP_057336	Q9NR09	BIRC6_HUMAN	baculoviral IAP repeat containing 6	3242					anti-apoptosis|apoptosis	intracellular	acid-amino acid ligase activity|cysteine-type endopeptidase inhibitor activity|protein binding			NS(4)|breast(8)|central_nervous_system(3)|endometrium(21)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(31)|lung(65)|ovary(7)|pancreas(1)|prostate(5)|skin(5)|stomach(1)|urinary_tract(5)	172	Acute lymphoblastic leukemia(172;0.155)					AGTGTCTGTTGAAGTAAGTGC	0.383000													7	13					0	0	1	0	0
ADCY2	108	broad.mit.edu	37	5	7804697	7804697	+	Splice_Site	SNP	G	G	T			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr5:7804697G>T	ENST00000338316.4	+	22	2864		c.e22-1		ADCY2_ENST00000537121.1_Splice_Site	NM_020546.2	NP_065433.2	Q08462	ADCY2_HUMAN	adenylate cyclase 2 (brain)						activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	cytoplasm|dendrite|integral to membrane|plasma membrane	ATP binding|metal ion binding	p.?(1)		NS(3)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|lung(56)|ovary(8)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	119						TTGCTTCACAGCTTCTTTCCA	0.478000													13	41					6.72482e-11	7.12291e-11	1	1	0
FAT4	79633	broad.mit.edu	37	4	126369882	126369882	+	Missense_Mutation	SNP	G	G	A			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr4:126369882G>A	ENST00000394329.3	+	9	7724	c.7711G>A	c.(7711-7713)Gaa>Aaa	p.E2571K	FAT4_ENST00000335110.5_Missense_Mutation_p.E869K	NM_024582.4	NP_078858.4	Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	2571	Cadherin 25.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						GAGAGCCAAAGAACAAACGTT	0.418000													12	28					0	0	1	0	0
ZFYVE9	9372	broad.mit.edu	37	1	52703859	52703859	+	Missense_Mutation	SNP	C	C	T			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr1:52703859C>T	ENST00000287727.3	+	4	942	c.770C>T	c.(769-771)tCc>tTc	p.S257F	ZFYVE9_ENST00000357206.2_Missense_Mutation_p.S257F|ZFYVE9_ENST00000371591.1_Missense_Mutation_p.S257F			O95405	ZFYV9_HUMAN	zinc finger, FYVE domain containing 9	257					endocytosis|SMAD protein complex assembly|SMAD protein import into nucleus|transforming growth factor beta receptor signaling pathway	early endosome membrane	metal ion binding|protein binding|receptor activity|serine-type peptidase activity			breast(1)|central_nervous_system(4)|endometrium(3)|kidney(1)|large_intestine(12)|lung(17)|ovary(2)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(6)	53						AGAGACCCCTCCATGTCTGCG	0.423000													58	210					0	0	1	0	0
ADH6	130	broad.mit.edu	37	4	100134834	100134834	+	Missense_Mutation	SNP	G	G	A			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr4:100134834G>A	ENST00000394897.1	-	3	273	c.191C>T	c.(190-192)cCc>cTc	p.P64L	ADH6_ENST00000407820.2_Intron|RP11-696N14.1_ENST00000500358.2_RNA|ADH6_ENST00000237653.7_Missense_Mutation_p.P64L|RP11-696N14.1_ENST00000506454.1_RNA|RP11-696N14.1_ENST00000506160.1_RNA|ADH6_ENST00000394899.2_Missense_Mutation_p.P64L			P28332	ADH6_HUMAN	alcohol dehydrogenase 6 (class V)	64					ethanol oxidation|response to ethanol|xenobiotic metabolic process	cytosol	alcohol dehydrogenase (NAD) activity|electron carrier activity|zinc ion binding			breast(1)|kidney(1)|large_intestine(6)|lung(9)|ovary(1)|skin(2)	20				OV - Ovarian serous cystadenocarcinoma(123;3.58e-08)	Abacavir(DB01048)|NADH(DB00157)	CAAGATGGTGGGATACAAGAG	0.493000													18	26					0	0	1	0	0
TSEN2	80746	broad.mit.edu	37	3	12533660	12533660	+	Missense_Mutation	SNP	C	C	T			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr3:12533660C>T	ENST00000444864.1	+	3	602	c.215C>T	c.(214-216)tCa>tTa	p.S72L	TSEN2_ENST00000402228.3_Missense_Mutation_p.S72L|TSEN2_ENST00000454502.2_Missense_Mutation_p.S72L|TSEN2_ENST00000314571.7_Missense_Mutation_p.S72L|TSEN2_ENST00000284995.6_Missense_Mutation_p.S72L|TSEN2_ENST00000415684.1_Missense_Mutation_p.S72L|TSEN2_ENST00000383797.5_Missense_Mutation_p.S72L	NM_001145395.1	NP_001138867.1	Q8NCE0	SEN2_HUMAN	TSEN2 tRNA splicing endonuclease subunit	72					mRNA processing|tRNA splicing, via endonucleolytic cleavage and ligation	cytoplasm|nucleolus|tRNA-intron endonuclease complex	nucleic acid binding|tRNA-intron endonuclease activity			central_nervous_system(2)|endometrium(2)|kidney(3)|large_intestine(5)|lung(7)	19						GGTATTCTTTCAAGAAGCCGT	0.338000													23	46					0	0	1	0	0
MYCN	4613	broad.mit.edu	37	2	16082732	16082732	+	Silent	SNP	G	G	T			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr2:16082732G>T	ENST00000281043.3	+	2	843	c.546G>T	c.(544-546)ccG>ccT	p.P182P		NM_005378.4	NP_005369.2	P04198	MYCN_HUMAN	v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog	182					regulation of transcription from RNA polymerase II promoter	chromatin|nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			NS(2)|autonomic_ganglia(1)|breast(1)|central_nervous_system(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(7)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(1)	31	all_cancers(1;1.35e-08)|all_neural(1;2.92e-24)|Lung SC(1;3.26e-07)|Medulloblastoma(1;6.9e-06)|all_lung(1;1.26e-05)|Glioma(3;0.135)|Acute lymphoblastic leukemia(172;0.155)|all_epithelial(1;0.169)|all_hematologic(175;0.197)		GBM - Glioblastoma multiforme(3;0.000332)			TCGCCCACCCGGCCGCCGAGT	0.831000			A		neuroblastoma								3	2					0.115264	0.115264	1	1	0
GIMAP6	474344	broad.mit.edu	37	7	150325268	150325268	+	Nonsense_Mutation	SNP	G	G	A			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr7:150325268G>A	ENST00000328902.5	-	3	634	c.418C>T	c.(418-420)Cag>Tag	p.Q140*	GIMAP6_ENST00000493969.1_3'UTR	NM_001244072.1|NM_024711.5	NP_001231001.1|NP_078987.3	Q6P9H5	GIMA6_HUMAN	GTPase, IMAP family member 6	140							GTP binding			endometrium(4)|kidney(1)|large_intestine(6)|lung(11)|ovary(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	29			OV - Ovarian serous cystadenocarcinoma(82;0.0145)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		ACCACCTGCTGATCCTCATCC	0.637000													29	65					0	0	1	0	0
BTBD7	55727	broad.mit.edu	37	14	93730169	93730169	+	Missense_Mutation	SNP	C	C	G			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr14:93730169C>G	ENST00000334746.5	-	4	1640	c.1333G>C	c.(1333-1335)Gac>Cac	p.D445H	BTBD7_ENST00000393170.2_Intron|BTBD7_ENST00000554565.1_Missense_Mutation_p.D94H	NM_001002860.2	NP_001002860.2	Q9P203	BTBD7_HUMAN	BTB (POZ) domain containing 7	445										breast(1)|endometrium(3)|kidney(3)|large_intestine(9)|lung(8)|ovary(1)|pancreas(1)|skin(8)|upper_aerodigestive_tract(1)	35		all_cancers(154;0.08)		Epithelial(152;0.196)|COAD - Colon adenocarcinoma(157;0.212)|all cancers(159;0.223)		AGCAGATGGTCTTTGCTGAGT	0.423000													42	9					0	0	1	0	0
PAX3	5077	broad.mit.edu	37	2	223096987	223096987	+	Nonsense_Mutation	SNP	G	G	C			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr2:223096987G>C	ENST00000350526.4	-	5	738	c.602C>G	c.(601-603)tCa>tGa	p.S201*	PAX3_ENST00000392069.2_Nonsense_Mutation_p.S201*|PAX3_ENST00000344493.4_Nonsense_Mutation_p.S201*|PAX3_ENST00000336840.6_Nonsense_Mutation_p.S201*|PAX3_ENST00000409551.3_Nonsense_Mutation_p.S200*|PAX3_ENST00000392070.2_Nonsense_Mutation_p.S201*	NM_181457.3	NP_852122.1	P23760	PAX3_HUMAN	paired box 3	201					apoptosis|organ morphogenesis|positive regulation of transcription from RNA polymerase II promoter|sensory perception of sound|transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		PAX3/NCOA2(4)|PAX3/NCOA1(8)|PAX3/FOXO1(749)	NS(1)|endometrium(3)|kidney(1)|large_intestine(12)|lung(13)|ovary(4)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	38		Renal(207;0.0183)		Epithelial(121;4.13e-10)|all cancers(144;1.85e-07)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GCCTTCATCTGATTGGGGTGC	0.428000			T	"""FOXO1A, NCOA1"""	alveolar rhabdomyosarcoma		Waardenburg syndrome; craniofacial-deafness-hand syndrome						14	49					0	0	1	0	0
TMEM143	55260	broad.mit.edu	37	19	48866599	48866599	+	Silent	SNP	G	G	A			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr19:48866599G>A	ENST00000293261.3	-	2	529	c.213C>T	c.(211-213)cgC>cgT	p.R71R	TMEM143_ENST00000598012.1_5'UTR|TMEM143_ENST00000541566.1_Intron|TMEM143_ENST00000436660.2_Silent_p.R71R|TMEM143_ENST00000377431.2_Silent_p.R71R|TMEM143_ENST00000435956.3_Silent_p.R71R	NM_018273.2	NP_060743.2	Q96AN5	TM143_HUMAN	transmembrane protein 143	71						integral to membrane|mitochondrion				endometrium(2)|kidney(1)|large_intestine(2)|lung(9)	14		all_epithelial(76;9.64e-05)|all_lung(116;0.000147)|Lung NSC(112;0.000251)|Prostate(7;0.0187)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000149)|all cancers(93;0.000198)|Epithelial(262;0.0151)|GBM - Glioblastoma multiforme(486;0.0157)		TGAAGCGCTCGCGGTACTGCT	0.662000													34	26					0	0	1	0	0
FDXR	2232	broad.mit.edu	37	17	72859208	72859208	+	Silent	SNP	G	G	A			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr17:72859208G>A	ENST00000442102.2	-	11	1550	c.1464C>T	c.(1462-1464)ctC>ctT	p.L488L	FDXR_ENST00000581530.1_Silent_p.L451L|FDXR_ENST00000582944.1_Silent_p.L437L|FDXR_ENST00000293195.5_Silent_p.L445L|FDXR_ENST00000420580.2_Silent_p.L405L|FDXR_ENST00000583917.1_Silent_p.L417L|FDXR_ENST00000455107.2_3'UTR|FDXR_ENST00000544854.1_Silent_p.L393L|FDXR_ENST00000413947.2_Silent_p.L476L	NM_001258012.1	NP_001244941.1	P22570	ADRO_HUMAN	ferredoxin reductase	445					cholesterol metabolic process|electron transport chain|steroid biosynthetic process|transport	mitochondrial matrix	ferredoxin-NADP+ reductase activity|protein binding			central_nervous_system(1)|cervix(1)|endometrium(1)|large_intestine(2)|lung(9)|prostate(1)|skin(1)	16	all_lung(278;0.172)|Lung NSC(278;0.207)					CTCGGCTGCTGAGCAGGGCCT	0.677000													4	30					0	0	1	0	0
USP9Y	8287	broad.mit.edu	37	Y	14952494	14952494	+	Silent	SNP	G	G	T			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chrY:14952494G>T	ENST00000338981.3	+	36	6987	c.6042G>T	c.(6040-6042)gtG>gtT	p.V2014V	USP9Y_ENST00000426564.2_3'UTR	NM_004654.3	NP_004645.2	O00507	USP9Y_HUMAN	ubiquitin specific peptidase 9, Y-linked	2014					BMP signaling pathway|protein deubiquitination|spermatogenesis|transforming growth factor beta receptor signaling pathway|ubiquitin-dependent protein catabolic process	cytoplasm	co-SMAD binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			kidney(1)|large_intestine(8)|lung(5)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	17						TTCAGTTTGTGAAAAAACTGC	0.323000													20	3					4.96729e-08	5.15241e-08	1	1	0
PTCHD3	374308	broad.mit.edu	37	10	27702331	27702331	+	Silent	SNP	G	G	A			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr10:27702331G>A	ENST00000438700.3	-	1	966	c.849C>T	c.(847-849)atC>atT	p.I283I		NM_001034842.3	NP_001030014.2	Q3KNS1	PTHD3_HUMAN	patched domain containing 3	283					spermatid development	integral to membrane	hedgehog receptor activity			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(17)|ovary(3)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)	55						CGGGGAAGGAGATGCTGCTCA	0.617000													7	53					0	0	1	0	0
MIER1	57708	broad.mit.edu	37	1	67450443	67450443	+	Missense_Mutation	SNP	G	G	T			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr1:67450443G>T	ENST00000357692.2	+	15	1707	c.1450G>T	c.(1450-1452)Gat>Tat	p.D484Y	MIER1_ENST00000371016.1_Intron|MIER1_ENST00000355356.3_Missense_Mutation_p.D467Y|MIER1_ENST00000355977.6_Intron|MIER1_ENST00000371018.3_Intron|MIER1_ENST00000371014.1_Intron|MIER1_ENST00000401041.1_Missense_Mutation_p.D520Y|MIER1_ENST00000401042.3_Intron	NM_001146110.1	NP_001139582.1	Q8N108	MIER1_HUMAN	mesoderm induction early response 1, transcriptional regulator	491					positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|signal transducer activity			breast(2)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(3)|ovary(1)|urinary_tract(3)	15						AAATGAAAATGATTTTGATGA	0.383000													13	41					2.27111e-07	2.35088e-07	1	1	0
COL27A1	85301	broad.mit.edu	37	9	117072974	117072974	+	Silent	SNP	G	G	A			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr9:117072974G>A	ENST00000356083.3	+	61	5973	c.5582G>A	c.(5581-5583)tGa>tAa	p.*1861*		NM_032888.2	NP_116277.2	Q8IZC6	CORA1_HUMAN	collagen, type XXVII, alpha 1	0					cell adhesion		extracellular matrix structural constituent			central_nervous_system(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(17)|lung(30)|ovary(4)|prostate(6)|skin(3)|soft_tissue(1)|stomach(1)|urinary_tract(3)	80						TGCTTCCTCTGACCTCTGACC	0.617000													53	11					0	0	1	0	0
DARS	1615	broad.mit.edu	37	2	136673798	136673798	+	Silent	SNP	C	C	T			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr2:136673798C>T	ENST00000264161.4	-	11	1319	c.1104G>A	c.(1102-1104)ctG>ctA	p.L368L	DARS_ENST00000537273.1_Silent_p.L268L	NM_001349.2	NP_001340.2	P14868	SYDC_HUMAN	aspartyl-tRNA synthetase	368					aspartyl-tRNA aminoacylation|protein complex assembly	cytosol|nuclear membrane|plasma membrane|soluble fraction	aminoacylase activity|aspartate-tRNA ligase activity|ATP binding|nucleic acid binding|protein binding			central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(3)|ovary(2)|urinary_tract(2)	15				BRCA - Breast invasive adenocarcinoma(221;0.168)	L-Aspartic Acid(DB00128)	AGACAAACCTCAGATCGTCTT	0.418000													24	18					0	0	1	0	0
RGS10	6001	broad.mit.edu	37	10	121285576	121285576	+	Missense_Mutation	SNP	C	C	T			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr10:121285576C>T	ENST00000392865.1	-	3	243	c.181G>A	c.(181-183)Gaa>Aaa	p.E61K	RGS10_ENST00000369101.3_Missense_Mutation_p.E67K|RGS10_ENST00000469575.1_5'UTR|RGS10_ENST00000369103.2_Missense_Mutation_p.E75K	NM_002925.3	NP_002916.1	O43665	RGS10_HUMAN	regulator of G-protein signaling 10	67	RGS.				negative regulation of signal transduction	cytoplasm|plasma membrane	GTPase activator activity|protein binding|signal transducer activity			breast(2)|large_intestine(1)|lung(3)	6		Lung NSC(174;0.094)|all_lung(145;0.123)		all cancers(201;0.00105)|GBM - Glioblastoma multiforme(135;0.195)		TTAAAATCTTCACATGCTAGC	0.308000													24	26					0	0	1	0	0
LTBP1	4052	broad.mit.edu	37	2	33500049	33500049	+	Nonsense_Mutation	SNP	C	C	T			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr2:33500049C>T	ENST00000404816.2	+	17	3114	c.2761C>T	c.(2761-2763)Cag>Tag	p.Q921*	LTBP1_ENST00000354476.3_Nonsense_Mutation_p.Q922*|LTBP1_ENST00000407925.1_Nonsense_Mutation_p.Q595*|LTBP1_ENST00000390003.4_Nonsense_Mutation_p.Q596*|LTBP1_ENST00000418533.2_Nonsense_Mutation_p.Q595*|LTBP1_ENST00000404525.1_Nonsense_Mutation_p.Q542*|LTBP1_ENST00000402934.1_Nonsense_Mutation_p.Q542*			Q14766	LTBP1_HUMAN	latent transforming growth factor beta binding protein 1	921	EGF-like 5; calcium-binding (Potential).				negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta	proteinaceous extracellular matrix	calcium ion binding|growth factor binding|transforming growth factor beta receptor activity			breast(2)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(13)|lung(60)|ovary(4)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(3)	108	all_hematologic(175;0.115)	Medulloblastoma(90;0.215)				TGAGTGTACTCAGGTCCAACA	0.413000													21	58					0	0	1	0	0
SNX15	29907	broad.mit.edu	37	11	64802362	64802362	+	Silent	SNP	A	A	G			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr11:64802362A>G	ENST00000377244.3	+	4	430	c.300A>G	c.(298-300)gcA>gcG	p.A100A	SNX15_ENST00000352068.5_Silent_p.A100A|RP11-399J13.3_ENST00000301886.3_3'UTR	NM_013306.4|NM_147777.3	NP_037438.2|NP_680086.2	Q9NRS6	SNX15_HUMAN	sorting nexin 15	100	PX.				cell communication|intracellular protein transport	cytoplasmic vesicle membrane|cytosol	phosphatidylinositol binding|protein transporter activity			endometrium(1)|large_intestine(1)|lung(6)|ovary(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	14						GAAAGGGGGCAGAGGACCTGC	0.612000													35	34					0	0	1	0	0
KAT6B	23522	broad.mit.edu	37	10	76602978	76602978	+	Silent	SNP	G	G	A			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr10:76602978G>A	ENST00000287239.4	+	3	852	c.363G>A	c.(361-363)ccG>ccA	p.P121P	KAT6B_ENST00000372724.1_Silent_p.P121P|KAT6B_ENST00000372714.1_Silent_p.P121P|KAT6B_ENST00000372711.1_Silent_p.P121P|KAT6B_ENST00000372725.1_Silent_p.P121P	NM_001256468.1|NM_012330.3	NP_001243397.1|NP_036462.2	Q8WYB5	MYST4_HUMAN	K(lysine) acetyltransferase 6B	121	H15.				histone H3 acetylation|negative regulation of transcription, DNA-dependent|nucleosome assembly|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	MOZ/MORF histone acetyltransferase complex|nucleosome	DNA binding|histone acetyltransferase activity|transcription factor binding|zinc ion binding										TTGAGGAGCCGAATGGCTCCT	0.478000													75	69					0	0	1	0	0
AHI1	54806	broad.mit.edu	37	6	135778639	135778639	+	Missense_Mutation	SNP	C	C	G			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr6:135778639C>G	ENST00000367800.4	-	7	1360	c.1144G>C	c.(1144-1146)Gat>Cat	p.D382H	AHI1_ENST00000457866.2_Missense_Mutation_p.D382H|AHI1_ENST00000327035.6_Missense_Mutation_p.D382H	NM_001134830.1	NP_001128302.1	Q8N157	AHI1_HUMAN	Abelson helper integration site 1	382						adherens junction|cilium|microtubule basal body				NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|lung(18)|ovary(1)	37	Breast(56;0.239)|Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00904)|OV - Ovarian serous cystadenocarcinoma(155;0.00991)		TACCTATCATCTTTCTTGACA	0.333000													6	17					0	0	1	0	0
RASGRP3	25780	broad.mit.edu	37	2	33741658	33741658	+	Silent	SNP	G	G	A			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr2:33741658G>A	ENST00000403687.3	+	4	860	c.120G>A	c.(118-120)ctG>ctA	p.L40L	RASGRP3_ENST00000402538.3_Silent_p.L40L|RASGRP3_ENST00000407811.1_Silent_p.L40L	NM_001139488.1	NP_001132960.1	Q8IV61	GRP3_HUMAN	RAS guanyl releasing protein 3 (calcium and DAG-regulated)	40	N-terminal Ras-GEF.				MAPKKK cascade|small GTPase mediated signal transduction	integral to plasma membrane|intracellular	calcium ion binding|diacylglycerol binding|guanyl-nucleotide exchange factor activity|protein binding|Rap GTPase activator activity|signal transducer activity			large_intestine(3)|lung(3)|ovary(2)|pancreas(1)|stomach(2)	11	all_hematologic(175;0.115)					TAGTTCTACTGATGCACCGAT	0.328000													3	6					0	0	1	0	0
MIB1	57534	broad.mit.edu	37	18	19444545	19444545	+	Missense_Mutation	SNP	G	G	A			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr18:19444545G>A	ENST00000261537.6	+	21	3203	c.2939G>A	c.(2938-2940)gGa>gAa	p.G980E	MIB1_ENST00000578646.1_3'UTR	NM_020774.2	NP_065825.1	Q86YT6	MIB1_HUMAN	mindbomb E3 ubiquitin protein ligase 1	980					Notch signaling pathway	centrosome|nuclear membrane|plasma membrane	ubiquitin-protein ligase activity|zinc ion binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(13)|ovary(5)	27			STAD - Stomach adenocarcinoma(5;0.212)			TGTGGTCACGGAACCTGTCAA	0.388000													11	55					0	0	1	0	0
DHX34	9704	broad.mit.edu	37	19	47883073	47883073	+	Missense_Mutation	SNP	G	G	T			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr19:47883073G>T	ENST00000328771.4	+	14	3162	c.2813G>T	c.(2812-2814)cGa>cTa	p.R938L		NM_014681.5	NP_055496.2	Q14147	DHX34_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 34	938						intracellular	ATP binding|ATP-dependent helicase activity|RNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(2)|lung(8)|ovary(5)|prostate(5)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	36		all_cancers(25;1.65e-09)|all_epithelial(76;9.95e-08)|all_lung(116;7.27e-07)|Lung NSC(112;1.6e-06)|Ovarian(192;0.0139)|all_neural(266;0.026)|Breast(70;0.0503)		all cancers(93;7.16e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.000489)|GBM - Glioblastoma multiforme(486;0.00413)|Epithelial(262;0.0132)		AGTGCCATCCGACTCCTGGCG	0.657000													64	46					2.60599e-31	2.88212e-31	1	1	0
LVRN	206338	broad.mit.edu	37	5	115351059	115351059	+	Missense_Mutation	SNP	A	A	G			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr5:115351059A>G	ENST00000357872.4	+	17	2685	c.2561A>G	c.(2560-2562)gAa>gGa	p.E854G	AQPEP_ENST00000515454.1_3'UTR	NM_173800.4	NP_776161.3	Q6Q4G3	AMPQ_HUMAN		854					proteolysis	integral to membrane	metallopeptidase activity|zinc ion binding										AACAAAGAAGAAAAGATTCAA	0.353000													11	25					0	0	1	0	0
T	6862	broad.mit.edu	37	6	166571930	166571930	+	Missense_Mutation	SNP	G	G	A			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr6:166571930G>A	ENST00000296946.2	-	9	1649	c.1181C>T	c.(1180-1182)tCt>tTt	p.S394F	T_ENST00000366871.3_Missense_Mutation_p.S336F	NM_003181.3	NP_003172.1	O15178	BRAC_HUMAN	T, brachyury homolog (mouse)	394					anterior/posterior axis specification, embryo|mesoderm development|primitive streak formation	nucleus	sequence-specific DNA binding transcription factor activity			autonomic_ganglia(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(23)|ovary(1)|pancreas(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	39		Prostate(117;4.48e-07)|Ovarian(120;1.78e-06)|Breast(66;2.54e-06)|Lung SC(201;0.0225)|Esophageal squamous(34;0.0559)		OV - Ovarian serous cystadenocarcinoma(33;1.09e-113)|GBM - Glioblastoma multiforme(31;1.51e-108)|BRCA - Breast invasive adenocarcinoma(81;8.45e-09)|LUAD - Lung adenocarcinoma(999;0.0407)		TCCCGAGGAAGAGGGCGCCGA	0.701000									Chordoma, Familial Clustering of				54	45					0	0	1	0	0
TOX2	84969	broad.mit.edu	37	20	42635357	42635357	+	Silent	SNP	C	C	T			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr20:42635357C>T	ENST00000358131.5	+	3	571	c.363C>T	c.(361-363)gcC>gcT	p.A121A	TOX2_ENST00000423191.2_Silent_p.A70A|TOX2_ENST00000341197.4_Silent_p.A112A|TOX2_ENST00000372999.1_Silent_p.A70A	NM_001098798.1	NP_001092268.1	Q96NM4	TOX2_HUMAN	TOX high mobility group box family member 2	121					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(13)|ovary(1)|skin(2)	26		Myeloproliferative disorder(115;0.00452)	COAD - Colon adenocarcinoma(18;0.00189)			CCTATCAGGCCATGGACCTCC	0.642000													18	36					0	0	1	0	0
ZMAT4	79698	broad.mit.edu	37	8	40438739	40438739	+	Silent	SNP	G	G	A			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr8:40438739G>A	ENST00000297737.6	-	6	765	c.619C>T	c.(619-621)Cta>Tta	p.L207L	ZMAT4_ENST00000315769.7_Silent_p.L131L	NM_024645.2	NP_078921.1	Q9H898	ZMAT4_HUMAN	zinc finger, matrin-type 4	207						nucleus	DNA binding|zinc ion binding			NS(2)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(4)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	18	Ovarian(28;0.00724)|Colorectal(14;0.0468)	all_cancers(7;0.00936)|all_epithelial(6;3.53e-06)|all_lung(54;0.0318)|Lung NSC(58;0.0919)|Esophageal squamous(32;0.15)|Hepatocellular(245;0.152)	LUSC - Lung squamous cell carcinoma(45;0.00722)			ATTGAGTTTAGGGAGACACTG	0.438000													13	141					0	0	1	0	0
HSP90AA1	3320	broad.mit.edu	37	14	102552143	102552143	+	Missense_Mutation	SNP	C	C	G			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr14:102552143C>G	ENST00000334701.7	-	4	1128	c.847G>C	c.(847-849)Gct>Cct	p.A283P	HSP90AA1_ENST00000216281.8_Missense_Mutation_p.A161P|HSP90AA1_ENST00000441629.2_Intron	NM_001017963.2	NP_001017963.2	P07900	HS90A_HUMAN	heat shock protein 90kDa alpha (cytosolic), class A member 1	161					axon guidance|cellular chaperone-mediated protein complex assembly|G2/M transition of mitotic cell cycle|nitric oxide metabolic process|positive regulation of nitric oxide biosynthetic process|protein import into mitochondrial outer membrane|protein refolding|regulation of nitric-oxide synthase activity|response to unfolded protein|signal transduction	cytosol|melanosome|plasma membrane	ATP binding|ATPase activity|nitric-oxide synthase regulator activity|protein homodimerization activity|TPR domain binding|unfolded protein binding			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(6)|large_intestine(3)|liver(1)|lung(10)|ovary(2)|prostate(1)	28					Rifabutin(DB00615)	GACTCCCAAGCGTACTGCTCA	0.478000													36	14					0	0	1	0	0
ARHGEF5	7984	broad.mit.edu	37	7	144060730	144060730	+	Missense_Mutation	SNP	G	G	A			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr7:144060730G>A	ENST00000056217.5	+	2	1142	c.968G>A	c.(967-969)gGa>gAa	p.G323E		NM_005435.3	NP_005426.2	Q12774	ARHG5_HUMAN	Rho guanine nucleotide exchange factor (GEF) 5	323					intracellular signal transduction|regulation of Rho protein signal transduction	intracellular	GTP binding|protein binding|Rho guanyl-nucleotide exchange factor activity			breast(1)|endometrium(6)|kidney(8)|large_intestine(9)|liver(1)|lung(8)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	40	Melanoma(164;0.14)					CCAGAACAGGGAGAAGAGAGG	0.542000													13	90					0	0	1	0	0
KIAA0947	23379	broad.mit.edu	37	5	5463270	5463270	+	Missense_Mutation	SNP	G	G	A			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr5:5463270G>A	ENST00000296564.7	+	13	4045	c.3823G>A	c.(3823-3825)Gaa>Aaa	p.E1275K		NM_015325.2	NP_056140.1	Q9Y2F5	K0947_HUMAN	KIAA0947	1275										breast(2)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(14)|ovary(1)|prostate(4)|upper_aerodigestive_tract(1)	35						AACAAATTCTGAAGATTGCAA	0.348000													4	22					0	0	1	0	0
CALCR	799	broad.mit.edu	37	7	93090216	93090216	+	Missense_Mutation	SNP	G	G	C			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr7:93090216G>C	ENST00000359558.2	-	10	966	c.667C>G	c.(667-669)Ctt>Gtt	p.L223V	CALCR_ENST00000426151.1_Missense_Mutation_p.L189V|CALCR_ENST00000394441.1_Missense_Mutation_p.L189V|CALCR_ENST00000360249.4_Missense_Mutation_p.L205V|CALCR_ENST00000421592.1_Missense_Mutation_p.L205V	NM_001164737.1	NP_001158209.1	P30988	CALCR_HUMAN	calcitonin receptor	205					activation of adenylate cyclase activity by G-protein signaling pathway|elevation of cytosolic calcium ion concentration|positive regulation of adenylate cyclase activity|response to glucocorticoid stimulus	integral to plasma membrane	calcitonin binding|calcitonin receptor activity|protein binding			NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(27)|ovary(3)|pancreas(1)|skin(3)	45	all_cancers(62;3.18e-12)|all_epithelial(64;1.34e-11)|Breast(17;0.000675)|Lung NSC(181;0.207)		STAD - Stomach adenocarcinoma(171;0.000244)		Salmon Calcitonin(DB00017)	ATGTAAGTAAGAAACATGTTC	0.438000													4	82					0	0	1	0	0
MXRA5	25878	broad.mit.edu	37	X	3239789	3239789	+	Missense_Mutation	SNP	G	G	A			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chrX:3239789G>A	ENST00000217939.6	-	5	4091	c.3937C>T	c.(3937-3939)Ctt>Ttt	p.L1313F		NM_015419.3	NP_056234.2	Q9NR99	MXRA5_HUMAN	matrix-remodelling associated 5	1313						extracellular region				NS(1)|biliary_tract(1)|breast(4)|central_nervous_system(3)|cervix(2)|endometrium(8)|kidney(2)|large_intestine(32)|lung(81)|ovary(6)|prostate(3)|skin(9)|stomach(3)|urinary_tract(2)	157		all_lung(23;0.00031)|Lung NSC(23;0.000946)				GTGACTGGAAGTGTCTCTTGG	0.363000													59	6					0	0	1	0	0
ST3GAL4	6484	broad.mit.edu	37	11	126279195	126279195	+	Silent	SNP	C	C	T			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr11:126279195C>T	ENST00000526727.1	+	8	1034	c.660C>T	c.(658-660)ctC>ctT	p.L220L	ST3GAL4_ENST00000532243.1_Silent_p.L219L|ST3GAL4_ENST00000530591.1_Silent_p.L216L|ST3GAL4_ENST00000392669.2_Silent_p.L220L|ST3GAL4_ENST00000227495.6_Silent_p.L216L|ST3GAL4_ENST00000534457.1_Silent_p.L215L|ST3GAL4_ENST00000444328.2_Silent_p.L220L|ST3GAL4_ENST00000534083.1_Silent_p.L220L|ST3GAL4_ENST00000449406.2_Silent_p.L209L|ST3GAL4_ENST00000356132.4_Silent_p.L226L			Q11206	SIA4C_HUMAN	ST3 beta-galactoside alpha-2,3-sialyltransferase 4	220					post-translational protein modification|protein N-linked glycosylation via asparagine	extracellular region|Golgi cisterna membrane|integral to Golgi membrane	beta-galactoside alpha-2,3-sialyltransferase activity			endometrium(1)|large_intestine(2)|lung(5)|stomach(1)	9	all_hematologic(175;0.145)	Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.0739)|all_lung(97;0.0798)|all_neural(223;0.138)		BRCA - Breast invasive adenocarcinoma(274;1.13e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0767)		AGCCTCCCCTCATCTGGGATG	0.517000													43	87					0	0	1	0	0
TEF	7008	broad.mit.edu	37	22	41791841	41791841	+	Silent	SNP	C	C	A			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr22:41791841C>A	ENST00000266304.4	+	4	905	c.789C>A	c.(787-789)atC>atA	p.I263I	TEF_ENST00000406644.3_Silent_p.I233I	NM_003216.3	NP_003207.1	Q10587	TEF_HUMAN	thyrotrophic embryonic factor	263					rhythmic process	nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			kidney(1)|large_intestine(2)|lung(2)|ovary(1)	6						AGATCACCATCCGGGCAGCCT	0.577000													30	52					1.06801e-11	1.13604e-11	1	1	0
ZNF610	162963	broad.mit.edu	37	19	52857575	52857575	+	Missense_Mutation	SNP	C	C	G			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr19:52857575C>G	ENST00000403906.3	+	5	718	c.262C>G	c.(262-264)Caa>Gaa	p.Q88E	ZNF610_ENST00000327920.8_Missense_Mutation_p.Q88E|ZNF610_ENST00000601151.1_Intron|ZNF610_ENST00000321287.8_Missense_Mutation_p.Q88E	NM_001161425.1	NP_001154897.1	Q8N9Z0	ZN610_HUMAN	zinc finger protein 610	88	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(1)|endometrium(3)|kidney(3)|large_intestine(8)|liver(2)|lung(9)|ovary(2)|stomach(2)|upper_aerodigestive_tract(2)	34				OV - Ovarian serous cystadenocarcinoma(262;0.00396)|GBM - Glioblastoma multiforme(134;0.00434)		TCTGCAAAGTCAAGTTAAAAT	0.378000													34	18					0	0	1	0	0
SEC24C	9632	broad.mit.edu	37	10	75527728	75527728	+	Missense_Mutation	SNP	T	T	C			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr10:75527728T>C	ENST00000339365.2	+	16	2306	c.2144T>C	c.(2143-2145)cTc>cCc	p.L715P	SEC24C_ENST00000345254.4_Missense_Mutation_p.L715P|SEC24C_ENST00000411652.2_Missense_Mutation_p.L596P|SEC24C_ENST00000535742.1_Intron|SEC24C_ENST00000540668.1_Intron|SEC24C_ENST00000496827.1_Intron	NM_004922.3	NP_004913.2	P53992	SC24C_HUMAN	SEC24 family member C	715					COPII vesicle coating|intracellular protein transport|post-translational protein modification|protein N-linked glycosylation via asparagine	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|Golgi membrane|perinuclear region of cytoplasm	protein binding|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(3)|lung(12)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	32	Prostate(51;0.0112)					GTGCCCCAGCTCACTGGTGGC	0.522000													11	20					0	0	1	0	0
PDE8A	5151	broad.mit.edu	37	15	85666302	85666302	+	Missense_Mutation	SNP	C	C	T			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr15:85666302C>T	ENST00000310298.4	+	20	2215	c.1963C>T	c.(1963-1965)Cgg>Tgg	p.R655W	PDE8A_ENST00000339708.5_Missense_Mutation_p.R609W|PDE8A_ENST00000557957.1_Missense_Mutation_p.R583W|PDE8A_ENST00000394553.1_Missense_Mutation_p.R655W			O60658	PDE8A_HUMAN	phosphodiesterase 8A	655	Catalytic (By similarity).				cyclic nucleotide metabolic process|regulation of transcription, DNA-dependent	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding|two-component response regulator activity			NS(1)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(4)|lung(8)|ovary(2)|pancreas(1)|prostate(1)|skin(2)	25	Colorectal(223;0.227)		BRCA - Breast invasive adenocarcinoma(143;0.0608)			GAATGATTATCGGACACTGCG	0.423000													35	20					0	0	1	0	0
ARMC10	83787	broad.mit.edu	37	7	102724142	102724142	+	Missense_Mutation	SNP	T	T	A			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr7:102724142T>A	ENST00000323716.3	+	3	650	c.258T>A	c.(256-258)gaT>gaA	p.D86E	ARMC10_ENST00000441711.2_Missense_Mutation_p.D51E|ARMC10_ENST00000425331.1_Missense_Mutation_p.D51E|ARMC10_ENST00000428183.2_Missense_Mutation_p.D86E|ARMC10_ENST00000541300.1_Missense_Mutation_p.D51E|ARMC10_ENST00000454559.1_Missense_Mutation_p.D51E	NM_031905.4	NP_114111.2	Q8N2F6	ARM10_HUMAN	armadillo repeat containing 10	86					regulation of growth	endoplasmic reticulum membrane|integral to membrane	binding			NS(1)|breast(1)|central_nervous_system(1)|large_intestine(2)|lung(3)|ovary(1)|prostate(1)|urinary_tract(1)	11						ACTTAACTGATGGTTCATATG	0.373000													38	13					0	0	1	0	0
MYO19	80179	broad.mit.edu	37	17	34858945	34858945	+	Missense_Mutation	SNP	C	C	G			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr17:34858945C>G	ENST00000431794.3	-	21	2594	c.2072G>C	c.(2071-2073)gGg>gCg	p.G691A	MYO19_ENST00000268852.9_Missense_Mutation_p.G491A	NM_001163735.1	NP_001157207.1	Q96H55	MYO19_HUMAN	myosin XIX	691						mitochondrial outer membrane|myosin complex	actin binding|ATP binding|motor activity			endometrium(6)|kidney(1)|large_intestine(2)|lung(8)|ovary(2)|urinary_tract(1)	20		Breast(25;0.00957)|Ovarian(249;0.17)	Kidney(155;0.104)	UCEC - Uterine corpus endometrioid carcinoma (308;0.0185)		ACCAGGGAGCCCTTTGGCAGG	0.527000													74	88					0	0	1	0	0
PROKR2	128674	broad.mit.edu	37	20	5282745	5282745	+	Missense_Mutation	SNP	C	C	G			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr20:5282745C>G	ENST00000546004.1	-	3	1342	c.1096G>C	c.(1096-1098)Gac>Cac	p.D366H	PROKR2_ENST00000217270.3_Missense_Mutation_p.D366H			Q8NFJ6	PKR2_HUMAN	prokineticin receptor 2	366						integral to membrane|plasma membrane	neuropeptide Y receptor activity			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|liver(3)|lung(22)|ovary(5)|pancreas(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(4)	53						GTTCTGAGGTCAAGGTCAGCA	0.547000										HNSCC(71;0.22)			16	48					0	0	1	0	0
UBE2L3	7332	broad.mit.edu	37	22	21965299	21965299	+	Nonsense_Mutation	SNP	G	G	T			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr22:21965299G>T	ENST00000342192.4	+	3	475	c.277G>T	c.(277-279)Gaa>Taa	p.E93*	UBE2L3_ENST00000458578.2_Nonsense_Mutation_p.E151*|UBE2L3_ENST00000545681.1_Nonsense_Mutation_p.E61*	NM_003347.3	NP_003338.1	P68036	UB2L3_HUMAN	ubiquitin-conjugating enzyme E2L 3	93					cell proliferation|cellular response to glucocorticoid stimulus|protein K11-linked ubiquitination|regulation of S phase of mitotic cell cycle|regulation of transcription, DNA-dependent|transcription, DNA-dependent|ubiquitin-dependent protein catabolic process	cytoplasm|nucleus|ubiquitin ligase complex	ATP binding|transcription coactivator activity|ubiquitin protein ligase binding|ubiquitin-protein ligase activity		UBE2L3/KRAS(2)	large_intestine(4)	4	Colorectal(54;0.105)					AATTAGTGCCGAAAACTGGAA	0.512000													8	42					0.000274275	0.00027704	1	1	0
KLHL4	56062	broad.mit.edu	37	X	86880669	86880669	+	Silent	SNP	C	C	G			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chrX:86880669C>G	ENST00000373119.4	+	6	1342	c.1197C>G	c.(1195-1197)ctC>ctG	p.L399L	KLHL4_ENST00000373114.4_Silent_p.L399L	NM_019117.4	NP_061990.2	Q9C0H6	KLHL4_HUMAN	kelch-like family member 4	399						cytoplasm|microtubule cytoskeleton|nucleolus	actin binding			NS(1)|biliary_tract(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(19)|lung(29)|ovary(2)|prostate(1)|skin(1)	67						GTCAGAAGCTCCTGATGGAAG	0.433000													29	3					0	0	1	0	0
IMPG2	50939	broad.mit.edu	37	3	100988366	100988366	+	Missense_Mutation	SNP	C	C	G			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr3:100988366C>G	ENST00000193391.7	-	8	1067	c.880G>C	c.(880-882)Gaa>Caa	p.E294Q		NM_016247.3	NP_057331.2	Q9BZV3	IMPG2_HUMAN	interphotoreceptor matrix proteoglycan 2	294	SEA 1.				visual perception	integral to membrane|proteinaceous extracellular matrix	extracellular matrix structural constituent|heparin binding|hyaluronic acid binding|receptor activity			NS(1)|breast(2)|cervix(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(14)|lung(32)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	64						TACCTAAATTCAAGTACACGA	0.269000													17	25					0	0	1	0	0
INPPL1	3636	broad.mit.edu	37	11	71941240	71941240	+	Missense_Mutation	SNP	G	G	C			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr11:71941240G>C	ENST00000298229.2	+	9	1219	c.1015G>C	c.(1015-1017)Gag>Cag	p.E339Q	INPPL1_ENST00000541756.1_Missense_Mutation_p.E97Q|INPPL1_ENST00000538751.1_Missense_Mutation_p.E97Q	NM_001567.3	NP_001558.3	O15357	SHIP2_HUMAN	inositol polyphosphate phosphatase-like 1	339					actin filament organization|cell adhesion|endocytosis	actin cortical patch|cytosol	actin binding|SH2 domain binding|SH3 domain binding			breast(2)|endometrium(9)|kidney(1)|large_intestine(7)|lung(12)|ovary(1)|pancreas(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	44						CGTGGATGTGGAGGGTGGGCG	0.637000													17	28					0	0	1	0	0
METAP1D	254042	broad.mit.edu	37	2	172930476	172930476	+	Missense_Mutation	SNP	G	G	C			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr2:172930476G>C	ENST00000315796.4	+	4	880	c.493G>C	c.(493-495)Gac>Cac	p.D165H	METAP1D_ENST00000488581.1_Intron	NM_199227.1	NP_954697.1	Q6UB28	AMP1D_HUMAN	methionyl aminopeptidase type 1D (mitochondrial)	165					N-terminal protein amino acid modification|peptidyl-methionine modification|proteolysis	mitochondrion	aminopeptidase activity|metal ion binding|metalloexopeptidase activity			NS(1)|endometrium(1)|large_intestine(2)|lung(3)|skin(1)	8						TGGTATTCCTGACAGGTATTC	0.358000													7	17					0	0	1	0	0
TRIML2	205860	broad.mit.edu	37	4	189026007	189026007	+	Missense_Mutation	SNP	C	C	G			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr4:189026007C>G	ENST00000512729.1	-	2	493	c.119G>C	c.(118-120)aGa>aCa	p.R40T	TRIML2_ENST00000536972.1_Missense_Mutation_p.R90T|TRIML2_ENST00000326754.3_Missense_Mutation_p.R40T	NM_173553.1	NP_775824.1	Q8N7C3	TRIMM_HUMAN	tripartite motif family-like 2	40							ligase activity			central_nervous_system(2)|kidney(1)|large_intestine(7)|lung(25)|prostate(3)|urinary_tract(1)	39		all_cancers(14;3.11e-44)|all_epithelial(14;7.86e-31)|all_lung(41;4.3e-13)|Lung NSC(41;9.69e-13)|Melanoma(20;7.86e-05)|Breast(6;0.000148)|all_hematologic(60;0.0202)|Hepatocellular(41;0.0218)|Renal(120;0.0376)|Prostate(90;0.0513)		OV - Ovarian serous cystadenocarcinoma(60;1.79e-11)|BRCA - Breast invasive adenocarcinoma(30;4.52e-06)|GBM - Glioblastoma multiforme(59;1.62e-05)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.0091)|READ - Rectum adenocarcinoma(43;0.163)		CATCGCCATTCTTTCTTGCTC	0.363000													33	20					0	0	1	0	0
POLE	5426	broad.mit.edu	37	12	133238238	133238238	+	Silent	SNP	C	C	T			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr12:133238238C>T	ENST00000320574.5	-	24	2782	c.2739G>A	c.(2737-2739)ctG>ctA	p.L913L	POLE_ENST00000535270.1_Silent_p.L886L	NM_006231.2	NP_006222.2	Q07864	DPOE1_HUMAN	polymerase (DNA directed), epsilon, catalytic subunit	913					base-excision repair, gap-filling|DNA synthesis involved in DNA repair|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	nucleoplasm	chromatin binding|DNA binding|DNA-directed DNA polymerase activity|nucleotide binding|protein binding|zinc ion binding			NS(2)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(41)|ovary(3)|pancreas(2)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	89	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0416)		OV - Ovarian serous cystadenocarcinoma(86;5.22e-08)|Epithelial(86;4.03e-07)|all cancers(50;1.18e-05)		ACGGCTCAGCCAGCTCCTGGT	0.542000								DNA polymerases (catalytic subunits)					69	207					0	0	1	0	0
IQCF1	132141	broad.mit.edu	37	3	51929156	51929156	+	Missense_Mutation	SNP	C	C	T	rs146704652		TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr3:51929156C>T	ENST00000310914.5	-	4	430	c.368G>A	c.(367-369)cGg>cAg	p.R123Q		NM_152397.2	NP_689610.2	Q8N6M8	IQCF1_HUMAN	IQ motif containing F1	123										central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(3)|ovary(1)|prostate(1)	12				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.000541)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)		CCACTCCTTCCGGGAGAAGGC	0.607000													46	63					0	0	1	0	0
TMEM243	79161	broad.mit.edu	37	7	86826053	86826053	+	Missense_Mutation	SNP	C	C	G			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr7:86826053C>G	ENST00000433078.1	-	5	697	c.256G>C	c.(256-258)Gac>Cac	p.D86H	TMEM243_ENST00000481425.1_5'UTR|TMEM243_ENST00000257637.3_Missense_Mutation_p.D86H					transmembrane protein 243, mitochondrial																		GGTTCTAAGTCTCCTTGTCGA	0.279000													9	21					0	0	1	0	0
ZIC5	85416	broad.mit.edu	37	13	100622424	100622424	+	Silent	SNP	G	G	A			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr13:100622424G>A	ENST00000267294.4	-	1	1739	c.1506C>T	c.(1504-1506)ttC>ttT	p.F502F		NM_033132.3	NP_149123.2	Q96T25	ZIC5_HUMAN	Zic family member 5	502					cell differentiation	nucleus	DNA binding|zinc ion binding			endometrium(3)|kidney(1)|lung(2)|prostate(1)|skin(2)	9	all_neural(89;0.0837)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)					CGGAGCGCGCGAAGACCTTGC	0.662000													32	53					0	0	1	0	0
SORT1	6272	broad.mit.edu	37	1	109897036	109897036	+	Missense_Mutation	SNP	T	T	G			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr1:109897036T>G	ENST00000256637.6	-	5	719	c.661A>C	c.(661-663)Atg>Ctg	p.M221L	SORT1_ENST00000538502.1_Missense_Mutation_p.M85L	NM_002959.5	NP_002950.3	Q99523	SORT_HUMAN	sortilin 1	221					endocytosis|endosome to lysosome transport|endosome transport via multivesicular body sorting pathway|glucose import|Golgi to endosome transport|induction of apoptosis by extracellular signals|myotube differentiation|negative regulation of apoptosis|negative regulation of lipoprotein lipase activity|neuropeptide signaling pathway|ossification|plasma membrane to endosome transport|regulation of gene expression|response to insulin stimulus|vesicle organization	cell surface|coated pit|early endosome|endoplasmic reticulum membrane|endosome membrane|Golgi cisterna membrane|integral to membrane|lysosomal membrane|microsome|nuclear membrane|perinuclear region of cytoplasm|plasma membrane	enzyme binding|nerve growth factor binding|nerve growth factor receptor activity|neurotensin receptor activity, non-G-protein coupled			NS(1)|breast(2)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(9)|lung(5)|ovary(2)|prostate(1)|skin(1)	26		all_epithelial(167;4.69e-05)|all_lung(203;0.00016)|Lung NSC(277;0.000318)|Breast(1374;0.244)		Lung(183;0.0529)|Colorectal(144;0.142)|Epithelial(280;0.145)|Kidney(133;0.169)|all cancers(265;0.184)		GGGCTATACATCATCTGAGTG	0.403000													19	44					0	0	1	0	0
HEATR5A	25938	broad.mit.edu	37	14	31785008	31785008	+	Missense_Mutation	SNP	C	C	G			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr14:31785008C>G	ENST00000543095.2	-	27	4370	c.4186G>C	c.(4186-4188)Gag>Cag	p.E1396Q	HEATR5A_ENST00000439348.1_Missense_Mutation_p.E1390Q|HEATR5A_ENST00000439727.1_Missense_Mutation_p.E1103Q|HEATR5A_ENST00000389961.3_Missense_Mutation_p.E1390Q	NM_015473.3	NP_056288.2	Q86XA9	HTR5A_HUMAN	HEAT repeat containing 5A	1390							binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(5)|lung(13)|ovary(1)	26	Hepatocellular(127;0.0877)|Breast(36;0.137)		LUAD - Lung adenocarcinoma(48;0.00292)|Lung(238;0.0164)|BRCA - Breast invasive adenocarcinoma(188;0.0797)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.0059)		GCTAAGATCTCCATGGTAGAA	0.373000													12	3					0	0	1	0	0
LINC00691	152024	broad.mit.edu	37	3	24138771	24138771	+	RNA	SNP	C	C	T			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr3:24138771C>T	ENST00000436123.1	-	0	1952																											CGAAACCGATCATCTTCATCG	0.453000													3	16					0	0	1	0	0
ZBBX	79740	broad.mit.edu	37	3	167031856	167031856	+	Silent	SNP	G	G	A			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr3:167031856G>A	ENST00000392766.2	-	16	1663	c.1323C>T	c.(1321-1323)ggC>ggT	p.G441G	ZBBX_ENST00000392767.2_Silent_p.G441G|ZBBX_ENST00000307529.5_Silent_p.G441G|ZBBX_ENST00000455345.2_Silent_p.G441G|ZBBX_ENST00000392764.1_Silent_p.G412G	NM_001199201.1|NM_024687.3	NP_001186130.1|NP_078963.2	A8MT70	ZBBX_HUMAN	zinc finger, B-box domain containing	441						intracellular	zinc ion binding			NS(1)|breast(1)|endometrium(5)|kidney(5)|large_intestine(9)|liver(1)|lung(38)|ovary(2)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)	70						GTTGATGGATGCCATTTTCAT	0.299000													17	57					0	0	1	0	0
CACNA1E	777	broad.mit.edu	37	1	181708285	181708285	+	Missense_Mutation	SNP	G	G	A			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr1:181708285G>A	ENST00000526775.1	+	24	3723	c.3558G>A	c.(3556-3558)atG>atA	p.M1186I	CACNA1E_ENST00000367573.2_Missense_Mutation_p.M1205I|CACNA1E_ENST00000367570.1_Missense_Mutation_p.M1205I|CACNA1E_ENST00000357570.5_Missense_Mutation_p.M1156I|CACNA1E_ENST00000367567.4_Missense_Mutation_p.M812I|CACNA1E_ENST00000360108.3_Missense_Mutation_p.M1186I|CACNA1E_ENST00000358338.5_Missense_Mutation_p.M1137I	NM_001205294.1	NP_001192223.1	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type, alpha 1E subunit	1205					energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			NS(2)|breast(9)|central_nervous_system(3)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(6)|kidney(4)|large_intestine(34)|lung(99)|ovary(6)|pancreas(1)|prostate(9)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	204						TTCTGCAGATGATAGACCAAG	0.537000													22	96					0	0	1	0	0
BBS5	129880	broad.mit.edu	37	2	170343586	170343586	+	Silent	SNP	C	C	T			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr2:170343586C>T	ENST00000295240.3	+	3	526	c.150C>T	c.(148-150)ctC>ctT	p.L50L	BBS5_ENST00000554017.1_Silent_p.L50L|RP11-724O16.1_ENST00000513963.1_Silent_p.L50L|BBS5_ENST00000392663.2_Silent_p.L50L	NM_152384.2	NP_689597.1			Bardet-Biedl syndrome 5											endometrium(1)|large_intestine(1)|lung(3)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	9						TAGGTAGACTCTTGGTAACAA	0.338000									Bardet-Biedl syndrome				4	103					0	0	1	0	0
QRSL1	55278	broad.mit.edu	37	6	107110891	107110891	+	Silent	SNP	G	G	A			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr6:107110891G>A	ENST00000369046.4	+	10	1301	c.1197G>A	c.(1195-1197)gtG>gtA	p.V399V		NM_018292.4	NP_060762.3	Q9H0R6	QRSL1_HUMAN	glutaminyl-tRNA synthase (glutamine-hydrolyzing)-like 1	399					translation		ATP binding|carbon-nitrogen ligase activity, with glutamine as amido-N-donor			endometrium(2)|kidney(1)|large_intestine(4)|lung(4)	11	Breast(9;0.0107)|all_epithelial(6;0.14)	all_cancers(87;0.00768)|Acute lymphoblastic leukemia(125;2.27e-07)|all_hematologic(75;1.38e-05)|all_epithelial(87;0.248)	Epithelial(6;0.000334)|all cancers(7;0.00157)|BRCA - Breast invasive adenocarcinoma(8;0.00721)|OV - Ovarian serous cystadenocarcinoma(5;0.0152)	BRCA - Breast invasive adenocarcinoma(108;0.118)|all cancers(137;0.167)|Epithelial(106;0.176)		CACAGAAAGTGAGACGCCTCA	0.348000													35	21					0	0	1	0	0
JMJD1C	221037	broad.mit.edu	37	10	64960285	64960285	+	Missense_Mutation	SNP	C	C	T			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr10:64960285C>T	ENST00000399262.2	-	11	5445	c.5227G>A	c.(5227-5229)Gaa>Aaa	p.E1743K	JMJD1C_ENST00000402544.1_Missense_Mutation_p.E1524K|JMJD1C_ENST00000399251.1_Intron|JMJD1C_ENST00000542921.1_Missense_Mutation_p.E1561K	NM_032776.1	NP_116165.1	Q15652	JHD2C_HUMAN	jumonji domain containing 1C	1743					blood coagulation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm	histone demethylase activity (H3-K9 specific)|metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|thyroid hormone receptor binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(8)|kidney(8)|large_intestine(9)|lung(27)|ovary(6)|prostate(4)|skin(4)|stomach(3)|upper_aerodigestive_tract(3)	77	Prostate(12;0.0119)|all_hematologic(501;0.191)					GCTGGTTCTTCTCCTTTTTTA	0.358000													4	17					0	0	1	0	0
HS3ST2	9956	broad.mit.edu	37	16	22826011	22826011	+	Missense_Mutation	SNP	C	C	T			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr16:22826011C>T	ENST00000261374.3	+	1	514	c.80C>T	c.(79-81)tCg>tTg	p.S27L		NM_006043.1	NP_006034.1	Q9Y278	HS3S2_HUMAN	heparan sulfate (glucosamine) 3-O-sulfotransferase 2	27						Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine 3-sulfotransferase 2 activity			breast(2)|kidney(1)|large_intestine(5)|liver(2)|lung(5)|ovary(1)|pancreas(2)|skin(1)	19				GBM - Glioblastoma multiforme(48;0.0299)		TTCACGCTCTCGCTCTCCTGC	0.726000													6	9					0	0	1	0	0
SHPRH	257218	broad.mit.edu	37	6	146268656	146268656	+	Silent	SNP	G	G	A			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr6:146268656G>A	ENST00000367503.3	-	6	1583	c.1185C>T	c.(1183-1185)gtC>gtT	p.V395V	SHPRH_ENST00000275233.7_Silent_p.V395V|SHPRH_ENST00000367505.2_Silent_p.V395V|SHPRH_ENST00000438092.2_Silent_p.V395V	NM_001042683.2	NP_001036148.2	Q149N8	SHPRH_HUMAN	SNF2 histone linker PHD RING helicase, E3 ubiquitin protein ligase	395					DNA repair|nucleosome assembly	nucleosome|nucleus	ATP binding|DNA binding|helicase activity|ligase activity|zinc ion binding			breast(2)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(15)|lung(33)|ovary(3)|pancreas(2)|prostate(7)|skin(1)|urinary_tract(1)	79		Ovarian(120;0.0365)		OV - Ovarian serous cystadenocarcinoma(155;1.47e-07)|GBM - Glioblastoma multiforme(68;0.0124)		CATCTTGCTTGACATCTTGTC	0.473000													44	49					0	0	1	0	0
IL4I1	259307	broad.mit.edu	37	19	50398435	50398435	+	Silent	SNP	G	G	A			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr19:50398435G>A	ENST00000595948.1	-	6	941	c.321C>T	c.(319-321)gtC>gtT	p.V107V	IL4I1_ENST00000341114.3_Silent_p.V107V|IL4I1_ENST00000391826.2_Silent_p.V85V	NM_001258018.1	NP_001244947.1	Q96RQ9	OXLA_HUMAN	interleukin 4 induced 1	85						lysosome	L-amino-acid oxidase activity			endometrium(3)|large_intestine(3)|lung(6)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	16		all_lung(116;1.47e-05)|all_neural(266;0.0459)|Ovarian(192;0.0481)		GBM - Glioblastoma multiforme(134;0.00245)|OV - Ovarian serous cystadenocarcinoma(262;0.0169)		CCAGGATGGTGACCTGAGGGA	0.657000													12	22					0	0	1	0	0
NUDT5	11164	broad.mit.edu	37	10	12209770	12209770	+	Silent	SNP	G	G	C			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr10:12209770G>C	ENST00000491614.1	-	10	986	c.591C>G	c.(589-591)gtC>gtG	p.V197V	NUDT5_ENST00000378952.3_5'UTR|NUDT5_ENST00000378937.3_Silent_p.V210V|SEC61A2_ENST00000495368.1_3'UTR|SEC61A2_ENST00000304267.8_Intron|NUDT5_ENST00000537776.1_Silent_p.V197V			Q9UKK9	NUDT5_HUMAN	nudix (nucleoside diphosphate linked moiety X)-type motif 5	197	Nudix hydrolase.				D-ribose catabolic process|ribonucleoside diphosphate catabolic process	intracellular	ADP-ribose diphosphatase activity|magnesium ion binding			breast(1)|large_intestine(1)|lung(4)|ovary(1)|pancreas(1)	8		Renal(717;0.228)				CGTAGGAATAGACCCTGGCGT	0.413000													23	57					0	0	1	0	0
MRPL38	64978	broad.mit.edu	37	17	73898165	73898165	+	Silent	SNP	C	C	T			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr17:73898165C>T	ENST00000309352.3	-	3	855	c.318G>A	c.(316-318)cgG>cgA	p.R106R	MRPL38_ENST00000409963.3_5'UTR|MRPL38_ENST00000585475.1_5'UTR	NM_032478.3	NP_115867.2	Q96DV4	RM38_HUMAN	mitochondrial ribosomal protein L38	106						actin cytoskeleton|mitochondrion|ribosome				ovary(1)|pancreas(1)|prostate(2)|skin(1)	5			all cancers(21;0.000154)|Epithelial(20;0.000156)|BRCA - Breast invasive adenocarcinoma(9;0.00936)|LUSC - Lung squamous cell carcinoma(166;0.154)			TGGCCTGTTTCCGTTCCAGTA	0.582000													7	13					0	0	1	0	0
RIPK3	11035	broad.mit.edu	37	14	24807160	24807160	+	Missense_Mutation	SNP	C	C	G			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr14:24807160C>G	ENST00000216274.5	-	6	969	c.751G>C	c.(751-753)Gag>Cag	p.E251Q		NM_006871.3	NP_006862.2	Q9Y572	RIPK3_HUMAN	receptor-interacting serine-threonine kinase 3	251	Protein kinase.				apoptosis|induction of apoptosis by extracellular signals	cytoplasm	ATP binding|protein binding|transcription coactivator activity			NS(1)|central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(7)|lung(4)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	23				GBM - Glioblastoma multiforme(265;0.0181)		CCGGGAGTCTCAGGCCCGGCT	0.597000													55	12					0	0	1	0	0
EVI2A	2123	broad.mit.edu	37	17	29645572	29645572	+	Missense_Mutation	SNP	G	G	C			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr17:29645572G>C	ENST00000247270.3	-	3	865	c.529C>G	c.(529-531)Cta>Gta	p.L177V	EVI2A_ENST00000462804.2_Missense_Mutation_p.L154V|EVI2A_ENST00000461237.1_Missense_Mutation_p.L154V|NF1_ENST00000581113.2_3'UTR|NF1_ENST00000356175.3_Intron|CTD-2370N5.3_ENST00000578584.1_Missense_Mutation_p.S93C|NF1_ENST00000358273.4_Intron	NM_001003927.2	NP_001003927.1	P22794	EVI2A_HUMAN	ecotropic viral integration site 2A	154						integral to membrane	transmembrane receptor activity	p.0?(8)|p.?(3)		breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|liver(1)|lung(6)|ovary(1)|upper_aerodigestive_tract(1)	14		all_cancers(10;6.97e-11)|all_epithelial(10;0.0051)|all_hematologic(16;0.0149)|Breast(31;0.0155)|Myeloproliferative disorder(56;0.0255)|Acute lymphoblastic leukemia(14;0.0257)|all_lung(9;0.0468)|Lung NSC(157;0.094)		UCEC - Uterine corpus endometrioid carcinoma (4;6.64e-05)|all cancers(4;5.94e-13)|Epithelial(4;7.98e-12)|OV - Ovarian serous cystadenocarcinoma(4;9.4e-12)|GBM - Glioblastoma multiforme(4;0.18)		ACAGTTGATAGAAATAGAAAG	0.393000													17	31					0	0	1	0	0
ZNF385B	151126	broad.mit.edu	37	2	180634321	180634321	+	Silent	SNP	G	G	A	rs61744327	byFrequency	TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr2:180634321G>A	ENST00000410066.1	-	3	765	c.162C>T	c.(160-162)aaC>aaT	p.N54N		NM_152520.4	NP_689733.3	Q569K4	Z385B_HUMAN	zinc finger protein 385B	54						nucleus	nucleic acid binding|zinc ion binding			breast(1)|kidney(1)|large_intestine(6)|lung(11)|ovary(1)|skin(4)|upper_aerodigestive_tract(2)	26			Epithelial(96;0.174)|OV - Ovarian serous cystadenocarcinoma(117;0.201)			GGGATTTGCCGTTGGAATGCA	0.567000													15	35					0	0	1	0	0
FCAR	2204	broad.mit.edu	37	19	55386818	55386818	+	Missense_Mutation	SNP	G	G	A			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr19:55386818G>A	ENST00000355524.3	+	2	77	c.67G>A	c.(67-69)Gaa>Aaa	p.E23K	FCAR_ENST00000353758.4_Intron|FCAR_ENST00000359272.4_Intron|FCAR_ENST00000345937.4_Missense_Mutation_p.E23K|FCAR_ENST00000391723.3_Intron|FCAR_ENST00000391724.3_Intron|FCAR_ENST00000391725.3_Missense_Mutation_p.E23K|FCAR_ENST00000469767.1_Missense_Mutation_p.E23K|FCAR_ENST00000482092.2_3'UTR|FCAR_ENST00000391726.3_Intron	NM_002000.2	NP_001991.1	P24071	FCAR_HUMAN	Fc fragment of IgA, receptor for	23					immune response	extracellular region|integral to plasma membrane	IgA binding|receptor activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(14)|ovary(1)|skin(2)	24				GBM - Glioblastoma multiforme(193;0.0443)		TCAGGCACAGGAAGGTAAGTG	0.438000													28	253					0	0	1	0	0
KALRN	8997	broad.mit.edu	37	3	124418747	124418747	+	Silent	SNP	G	G	C			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr3:124418747G>C	ENST00000291478.5	+	23	2935	c.2772G>C	c.(2770-2772)tcG>tcC	p.S924S	KALRN_ENST00000428018.2_Silent_p.S892S|KALRN_ENST00000360013.3_Silent_p.S2621S	NM_007064.3	NP_008995.2	O60229	KALRN_HUMAN	kalirin, RhoGEF kinase						apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|vesicle-mediated transport	actin cytoskeleton|cytosol	ATP binding|GTPase activator activity|metal ion binding|protein binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(21)|lung(28)|ovary(4)|prostate(5)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	83						CAGTGGCTTCGACCTTGGACA	0.512000													38	115					0	0	1	0	0
TNNI3K	51086	broad.mit.edu	37	1	74929232	74929232	+	Missense_Mutation	SNP	G	G	A			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr1:74929232G>A	ENST00000370891.2	+	23	2438	c.2422G>A	c.(2422-2424)Gaa>Aaa	p.E808K	TNNI3K_ENST00000326637.3_Missense_Mutation_p.E707K|FPGT-TNNI3K_ENST00000370899.3_Missense_Mutation_p.E808K|FPGT-TNNI3K_ENST00000557284.2_Missense_Mutation_p.E821K	NM_001112808.2	NP_001106279.2			TNNI3 interacting kinase											cervix(1)|endometrium(3)|kidney(5)|large_intestine(21)|lung(31)|ovary(4)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(3)	76						CGCATGTCCTGAAGTGAGTAA	0.413000													13	235					0	0	1	0	0
SNX18	112574	broad.mit.edu	37	5	53814457	53814457	+	Silent	SNP	G	G	A			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr5:53814457G>A	ENST00000343017.6	+	1	869	c.675G>A	c.(673-675)gtG>gtA	p.V225V	SNX18_ENST00000326277.3_Silent_p.V225V|SNX18_ENST00000381410.4_Silent_p.V225V	NM_001145427.1	NP_001138899.1	Q96RF0	SNX18_HUMAN	sorting nexin 18	225					cell communication|endocytosis|positive regulation of GTPase activity|protein transport	endomembrane system|endosome membrane|extrinsic to internal side of plasma membrane	phosphatidylinositol binding|protein binding			endometrium(3)|kidney(1)|large_intestine(3)|lung(6)|prostate(2)|stomach(1)|upper_aerodigestive_tract(2)	18		Lung NSC(810;3.46e-05)|Breast(144;0.102)				CGGCCACCGTGAGCCGCAACC	0.701000													18	50					0	0	1	0	0
USP29	57663	broad.mit.edu	37	19	57640569	57640569	+	Missense_Mutation	SNP	G	G	C			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr19:57640569G>C	ENST00000254181.4	+	4	980	c.526G>C	c.(526-528)Gat>Cat	p.D176H	USP29_ENST00000598197.1_Missense_Mutation_p.D176H	NM_020903.2	NP_065954.1	Q9HBJ7	UBP29_HUMAN	ubiquitin specific peptidase 29	176					protein modification process|ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|protein binding|ubiquitin thiolesterase activity			breast(3)|endometrium(4)|kidney(3)|large_intestine(15)|lung(47)|ovary(2)|pancreas(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	85		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		ACTATCATCTGATGTACAGAC	0.353000													30	118					0	0	1	0	0
SLIT1	6585	broad.mit.edu	37	10	98824581	98824581	+	Missense_Mutation	SNP	G	G	C			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr10:98824581G>C	ENST00000266058.4	-	6	783	c.538C>G	c.(538-540)Ctg>Gtg	p.L180V	SLIT1_ENST00000371041.3_Missense_Mutation_p.L180V|ARHGAP19-SLIT1_ENST00000453547.2_3'UTR|SLIT1_ENST00000371070.4_Missense_Mutation_p.L180V	NM_003061.2	NP_003052.2	O75093	SLIT1_HUMAN	slit homolog 1 (Drosophila)	180					axon extension involved in axon guidance|forebrain morphogenesis|motor axon guidance|negative chemotaxis|negative regulation of synaptogenesis	cytoplasm|extracellular space	calcium ion binding|Roundabout binding			breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(37)|ovary(5)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	78		Colorectal(252;0.162)		Epithelial(162;2.02e-08)|all cancers(201;1.5e-06)		AGCCCCCGCAGAGCACGGAAG	0.582000													26	104					0	0	1	0	0
LYPD3	27076	broad.mit.edu	37	19	43967302	43967302	+	Missense_Mutation	SNP	C	C	T	rs149622525	byFrequency	TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr19:43967302C>T	ENST00000244333.3	-	4	608	c.520G>A	c.(520-522)Gac>Aac	p.D174N		NM_014400.2	NP_055215.2	O95274	LYPD3_HUMAN	LY6/PLAUR domain containing 3	174	UPAR/Ly6 2.					anchored to plasma membrane				cervix(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(1)|pancreas(1)|upper_aerodigestive_tract(2)	11		Prostate(69;0.0153)				ACGTTGCCGTCGAAGCAGCCC	0.657000													52	59					0	0	1	0	0
NPHP3	27031	broad.mit.edu	37	3	132409476	132409476	+	Nonsense_Mutation	SNP	C	C	T			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr3:132409476C>T	ENST00000337331.5	-	19	2675	c.2589G>A	c.(2587-2589)tgG>tgA	p.W863*	NPHP3_ENST00000326682.8_3'UTR	NM_153240.4	NP_694972.3	Q7Z494	NPHP3_HUMAN	nephronophthisis 3 (adolescent)	863					maintenance of organ identity|negative regulation of canonical Wnt receptor signaling pathway|photoreceptor cell maintenance|regulation of Wnt receptor signaling pathway, planar cell polarity pathway|Wnt receptor signaling pathway	cilium	protein binding			NS(1)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(5)|lung(15)|ovary(2)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	42						CTGCACTTCTCCAAGTCACTC	0.408000													31	48					0	0	1	0	0
WNK1	65125	broad.mit.edu	37	12	988982	988982	+	Silent	SNP	C	C	T			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr12:988982C>T	ENST00000315939.6	+	11	3260	c.2617C>T	c.(2617-2619)Ctg>Ttg	p.L873L	WNK1_ENST00000535572.1_Intron|WNK1_ENST00000530271.2_Silent_p.L1371L|WNK1_ENST00000340908.4_Silent_p.L466L|WNK1_ENST00000537687.1_Intron	NM_018979.3	NP_061852.3	Q9H4A3	WNK1_HUMAN	WNK lysine deficient protein kinase 1	873					intracellular protein kinase cascade|ion transport|neuron development	cytoplasm	ATP binding|protein binding|protein kinase inhibitor activity|protein serine/threonine kinase activity			breast(7)|central_nervous_system(1)|endometrium(3)|kidney(6)|large_intestine(15)|lung(43)|ovary(6)|prostate(3)|skin(7)|stomach(8)|upper_aerodigestive_tract(3)|urinary_tract(2)	104	all_cancers(10;0.00611)|all_epithelial(11;0.00825)|all_lung(10;0.0331)|Ovarian(42;0.0512)|Lung NSC(10;0.0632)		Epithelial(1;1.74e-08)|all cancers(1;7.04e-08)|OV - Ovarian serous cystadenocarcinoma(31;0.000423)|BRCA - Breast invasive adenocarcinoma(9;0.0149)|Colorectal(1;0.0197)			TACTCAGCCTCTGCTCACGTT	0.532000													34	74					0	0	1	0	0
DCLRE1C	64421	broad.mit.edu	37	10	14974888	14974888	+	Missense_Mutation	SNP	G	G	A			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr10:14974888G>A	ENST00000453695.2	-	9	829	c.385C>T	c.(385-387)Cgc>Tgc	p.R129C	DCLRE1C_ENST00000378254.1_Missense_Mutation_p.R129C|DCLRE1C_ENST00000378278.2_Missense_Mutation_p.R249C|DCLRE1C_ENST00000378249.1_Missense_Mutation_p.R134C|DCLRE1C_ENST00000378289.4_Missense_Mutation_p.R249C|DCLRE1C_ENST00000357717.2_Missense_Mutation_p.R134C|DCLRE1C_ENST00000396817.2_Missense_Mutation_p.R129C|DCLRE1C_ENST00000378258.1_Missense_Mutation_p.R129C|DCLRE1C_ENST00000378255.1_Missense_Mutation_p.R129C|DCLRE1C_ENST00000378246.2_Missense_Mutation_p.R134C	NM_001033855.1	NP_001029027.1	Q96SD1	DCR1C_HUMAN	DNA cross-link repair 1C	249					DNA recombination	nucleus	5'-3' exonuclease activity|single-stranded DNA specific endodeoxyribonuclease activity			breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(7)|ovary(1)	17						TGAGTGTTGCGGTCTGTTGTG	0.418000								Non-homologous end-joining					19	63					0	0	1	0	0
RRP12	23223	broad.mit.edu	37	10	99130304	99130304	+	Missense_Mutation	SNP	G	G	A			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr10:99130304G>A	ENST00000370992.4	-	23	2708	c.2597C>T	c.(2596-2598)aCc>aTc	p.T866I	RRP12_ENST00000536831.1_Missense_Mutation_p.T584I|RRP12_ENST00000414986.1_Missense_Mutation_p.T805I|RRP12_ENST00000315563.6_Missense_Mutation_p.T766I|RRP12_ENST00000479481.1_5'UTR	NM_015179.3	NP_055994.2	Q5JTH9	RRP12_HUMAN	ribosomal RNA processing 12 homolog (S. cerevisiae)	866						integral to membrane|nuclear membrane|nucleolus	protein binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(5)|large_intestine(2)|lung(13)|ovary(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	37		Colorectal(252;0.162)		Epithelial(162;2.72e-09)|all cancers(201;1.76e-07)		CACCTCCTTGGTGCACAGGAT	0.597000													14	38					0	0	1	0	0
SEC24C	9632	broad.mit.edu	37	10	75527713	75527713	+	Missense_Mutation	SNP	C	C	G			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr10:75527713C>G	ENST00000339365.2	+	16	2291	c.2129C>G	c.(2128-2130)tCt>tGt	p.S710C	SEC24C_ENST00000345254.4_Missense_Mutation_p.S710C|SEC24C_ENST00000411652.2_Missense_Mutation_p.S591C|SEC24C_ENST00000535742.1_Intron|SEC24C_ENST00000540668.1_Intron|SEC24C_ENST00000496827.1_Intron	NM_004922.3	NP_004913.2	P53992	SC24C_HUMAN	SEC24 family member C	710					COPII vesicle coating|intracellular protein transport|post-translational protein modification|protein N-linked glycosylation via asparagine	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|Golgi membrane|perinuclear region of cytoplasm	protein binding|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(3)|lung(12)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	32	Prostate(51;0.0112)					GCCACACTCTCTGTTGTGCCC	0.537000													13	16					0	0	1	0	0
LIN28A	79727	broad.mit.edu	37	1	26737974	26737974	+	Silent	SNP	C	C	T			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr1:26737974C>T	ENST00000326279.6	+	2	243	c.129C>T	c.(127-129)atC>atT	p.I43I	LIN28A_ENST00000254231.4_Silent_p.I43I	NM_024674.4	NP_078950.1	Q9H9Z2	LN28A_HUMAN	lin-28 homolog A (C. elegans)	43	CSD.				miRNA catabolic process|pre-miRNA processing|regulation of transcription, DNA-dependent|RNA 3'-end processing|stem cell maintenance	cytoplasmic mRNA processing body|nucleolus|stress granule	DNA binding|zinc ion binding			central_nervous_system(1)|cervix(1)|endometrium(1)|large_intestine(3)|lung(2)	8						GTGCGGGCATCTGTAAGTGGT	0.711000													11	24					0	0	1	0	0
HERC2P3	283755	broad.mit.edu	37	15	20588568	20588568	+	RNA	SNP	C	C	T			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr15:20588568C>T	ENST00000428453.1	-	0	4182																				central_nervous_system(1)|endometrium(11)|kidney(2)|large_intestine(1)|lung(14)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	35						TGCAGAAGCCCAGTAGGCATC	0.453000													8	11					0	0	1	0	0
HNRNPA0	10949	broad.mit.edu	37	5	137088854	137088854	+	Missense_Mutation	SNP	C	C	G			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr5:137088854C>G	ENST00000314940.4	-	1	1185	c.902G>C	c.(901-903)gGa>gCa	p.G301A		NM_006805.3	NP_006796.1	Q13151	ROA0_HUMAN	heterogeneous nuclear ribonucleoprotein A0	301	Gly-rich.				nuclear mRNA splicing, via spliceosome	heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	nucleotide binding|RNA binding			large_intestine(1)|lung(2)|skin(1)	4			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			GGAGCTGCCTCCATAGCCACC	0.592000													9	44					0	0	1	0	0
HUS1B	135458	broad.mit.edu	37	6	656479	656479	+	Missense_Mutation	SNP	T	T	A			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr6:656479T>A	ENST00000380907.2	-	1	484	c.466A>T	c.(466-468)Agc>Tgc	p.S156C	EXOC2_ENST00000230449.4_Intron|EXOC2_ENST00000448181.3_Intron	NM_148959.3	NP_683762.2	Q8NHY5	HUS1B_HUMAN	HUS1 checkpoint homolog b (S. pombe)	156										endometrium(3)|large_intestine(1)|lung(7)	11	Ovarian(93;0.0733)	Breast(5;0.00139)|all_lung(73;0.0691)|all_hematologic(90;0.0895)		OV - Ovarian serous cystadenocarcinoma(45;0.041)|BRCA - Breast invasive adenocarcinoma(62;0.0965)		AGGCGGATGCTCGCGTCGGAG	0.697000													38	79					0	0	1	0	0
SYT5	6861	broad.mit.edu	37	19	55690344	55690344	+	Nonsense_Mutation	SNP	G	G	T			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr19:55690344G>T	ENST00000590851.1	-	1	414	c.230C>A	c.(229-231)tCa>tAa	p.S77*	SYT5_ENST00000354308.3_Silent_p.I22I|SYT5_ENST00000537500.1_Silent_p.I22I			O00445	SYT5_HUMAN	synaptotagmin V	370					energy reserve metabolic process|regulation of insulin secretion|synaptic transmission	cell junction|integral to membrane|recycling endosome membrane|synaptic vesicle membrane	metal ion binding|transporter activity			kidney(2)|large_intestine(5)|lung(6)|ovary(1)|prostate(2)|skin(1)|urinary_tract(1)	18			BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0452)		GGCCGTGGCTGATGCGACTGG	0.687000													32	19					2.75727e-19	2.99652e-19	1	1	0
DDX4	54514	broad.mit.edu	37	5	55077779	55077779	+	Nonsense_Mutation	SNP	C	C	T			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr5:55077779C>T	ENST00000505374.1	+	10	687	c.595C>T	c.(595-597)Caa>Taa	p.Q199*	DDX4_ENST00000354991.5_Nonsense_Mutation_p.Q165*|DDX4_ENST00000514278.2_Nonsense_Mutation_p.Q179*|DDX4_ENST00000511853.1_Nonsense_Mutation_p.Q66*|DDX4_ENST00000353507.5_Nonsense_Mutation_p.Q165*	NM_024415.2	NP_077726.1	Q9NQI0	DDX4_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 4	199	Gly-rich.				multicellular organismal development|sperm motility	perinuclear region of cytoplasm|pi-body|piP-body	ATP binding|ATP-dependent helicase activity|nucleic acid binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(8)|ovary(1)|skin(3)|upper_aerodigestive_tract(2)	24		Lung NSC(810;6.93e-05)|all_neural(839;0.00409)|Prostate(74;0.0107)|Breast(144;0.0544)|Ovarian(174;0.223)				TGATACTTCTCAAAGCAGAAG	0.338000													14	17					0	0	1	0	0
HECTD4	283450	broad.mit.edu	37	12	112630478	112630478	+	Missense_Mutation	SNP	C	C	A			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr12:112630478C>A	ENST00000550722.1	-	59	9135	c.8740G>T	c.(8740-8742)Gcc>Tcc	p.A2914S	HECTD4_ENST00000430131.2_Missense_Mutation_p.A2638S|HECTD4_ENST00000377560.5_Missense_Mutation_p.A2888S	NM_001109662.3	NP_001103132.3			HECT domain containing E3 ubiquitin protein ligase 4																		TAACAGGCGGCCTCGATGAGG	0.632000													5	5					0.014758	0.0147875	1	1	0
ARHGAP19-SLIT1	100533184	broad.mit.edu	37	10	99003773	99003773	+	Silent	SNP	G	G	A			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr10:99003773G>A	ENST00000453547.2	-	8	1136	c.1137C>T	c.(1135-1137)caC>caT	p.H379H	ARHGAP19-SLIT1_ENST00000316676.8_Silent_p.H379H|ARHGAP19_ENST00000487035.1_5'UTR|ARHGAP19-SLIT1_ENST00000358308.3_Silent_p.H350H|ARHGAP19_ENST00000371027.1_Silent_p.H370H|ARHGAP19_ENST00000358531.4_Silent_p.H379H|ARHGAP19_ENST00000355366.5_Silent_p.H370H																							TATCATGAACGTGTTGAAACA	0.498000													41	28					0	0	1	0	0
CA4	762	broad.mit.edu	37	17	58227431	58227431	+	Silent	SNP	G	G	A			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr17:58227431G>A	ENST00000300900.4	+	1	135	c.36G>A	c.(34-36)gcG>gcA	p.A12A		NM_000717.3	NP_000708.1	P22748	CAH4_HUMAN	carbonic anhydrase IV	12					bicarbonate transport|one-carbon metabolic process	anchored to external side of plasma membrane|apical plasma membrane|brush border membrane|ER-Golgi intermediate compartment|membrane fraction|perinuclear region of cytoplasm|rough endoplasmic reticulum|secretory granule membrane|trans-Golgi network|transport vesicle membrane	carbonate dehydratase activity|protein binding|zinc ion binding			kidney(1)|large_intestine(2)|lung(5)|ovary(1)	9	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		Epithelial(12;3.83e-12)|all cancers(12;6.83e-11)		Bendroflumethiazide(DB00436)|Benzthiazide(DB00562)|Chlorothiazide(DB00880)|Cyclothiazide(DB00606)|Diazoxide(DB01119)|Hydrochlorothiazide(DB00999)|Hydroflumethiazide(DB00774)|Methyclothiazide(DB00232)|Quinethazone(DB01325)|Topiramate(DB00273)|Trichlormethiazide(DB01021)	CCCTCTCCGCGGCGCGGCCAT	0.751000													17	11					0	0	1	0	0
PRF1	5551	broad.mit.edu	37	10	72358421	72358421	+	Silent	SNP	G	G	A			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr10:72358421G>A	ENST00000441259.1	-	3	1216	c.1056C>T	c.(1054-1056)agC>agT	p.S352S	PRF1_ENST00000373209.2_Silent_p.S352S	NM_001083116.1|NM_005041.4	NP_001076585.1|NP_005032.2	P14222	PERF_HUMAN	perforin 1 (pore forming protein)	352	MACPF.				apoptosis|cellular defense response|cytolysis|defense response to tumor cell|defense response to virus|immune response to tumor cell|protein homooligomerization	cytolytic granule|endosome lumen|extracellular region|integral to membrane|plasma membrane	calcium ion binding|protein binding|wide pore channel activity			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(11)|ovary(1)|prostate(3)|urinary_tract(3)	23						GCGGGTCCTGGCTGTCCAGCA	0.711000			M			"""various leukaemia, lymphoma"""	Type 2 familial hemophagocytic lymphohistiocytosis		Familial Hemophagocytic Lymphohistiocytosis				11	27					0	0	1	0	0
KAT5	10524	broad.mit.edu	37	11	65480946	65480946	+	Missense_Mutation	SNP	C	C	T			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr11:65480946C>T	ENST00000341318.4	+	4	746	c.512C>T	c.(511-513)tCc>tTc	p.S171F	KAT5_ENST00000534650.1_Intron|KAT5_ENST00000530446.1_Intron|KAT5_ENST00000377046.3_Missense_Mutation_p.S138F|KAT5_ENST00000525204.1_3'UTR|KAT5_ENST00000352980.4_Intron	NM_182710.2	NP_874369.1	Q92993	KAT5_HUMAN	K(lysine) acetyltransferase 5	138					androgen receptor signaling pathway|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|double-strand break repair|interspecies interaction between organisms|negative regulation of interleukin-2 production|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|regulation of growth|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nucleolus|perinuclear region of cytoplasm|Piccolo NuA4 histone acetyltransferase complex	androgen receptor binding|histone acetyltransferase activity|metal ion binding|repressing transcription factor binding|transcription coactivator activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(9)	21						TCCTCCAGCTCCTGCCTGCAG	0.612000													55	35					0	0	1	0	0
PPP2R5B	5526	broad.mit.edu	37	11	64695868	64695868	+	Silent	SNP	C	C	T			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr11:64695868C>T	ENST00000164133.2	+	6	1315	c.693C>T	c.(691-693)atC>atT	p.I231I		NM_006244.3	NP_006235.1	Q15173	2A5B_HUMAN	protein phosphatase 2, regulatory subunit B', beta	231					signal transduction	cytoplasm|protein phosphatase type 2A complex	protein binding|protein phosphatase type 2A regulator activity			central_nervous_system(2)|endometrium(4)|kidney(1)|large_intestine(3)|lung(9)|ovary(2)	21						GGGCCTACATCCGCAAACAGT	0.592000													8	54					0	0	1	0	0
GPR151	134391	broad.mit.edu	37	5	145894881	145894881	+	Missense_Mutation	SNP	C	C	T			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr5:145894881C>T	ENST00000311104.2	-	1	872	c.796G>A	c.(796-798)Gaa>Aaa	p.E266K		NM_194251.2	NP_919227.2	Q8TDV0	GP151_HUMAN	G protein-coupled receptor 151	266						integral to membrane|plasma membrane	G-protein coupled receptor activity			endometrium(2)|large_intestine(1)|lung(6)|ovary(1)|pancreas(1)|skin(1)|urinary_tract(2)	14			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			GCTACCCATTCGGGGAGCCAC	0.507000													15	42					0	0	1	0	0
BNIP1	662	broad.mit.edu	37	5	172571488	172571488	+	Translation_Start_Site	SNP	G	G	A			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr5:172571488G>A	ENST00000231668.9	+	0	44				CTC-209H22.3_ENST00000521251.1_RNA	NM_013979.2	NP_053582.2	Q12981	SEC20_HUMAN	BCL2/adenovirus E1B 19kDa interacting protein 1						anti-apoptosis|apoptosis|endoplasmic reticulum membrane fusion|endoplasmic reticulum organization|induction of apoptosis|vesicle-mediated transport	integral to endoplasmic reticulum membrane|nuclear envelope|SNARE complex	protein binding			breast(1)|kidney(2)|large_intestine(2)|lung(3)|ovary(1)|pancreas(1)|skin(1)	11	Renal(175;0.000159)|Lung NSC(126;0.00199)|all_lung(126;0.00351)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000183)			AGGGAAAGAAGGTGGTGCGAA	0.637000											OREG0017054	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	20	7					0	0	1	0	0
BAZ2B	29994	broad.mit.edu	37	2	160287599	160287599	+	Missense_Mutation	SNP	C	C	G			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr2:160287599C>G	ENST00000392783.2	-	10	2464	c.1969G>C	c.(1969-1971)Gat>Cat	p.D657H	BAZ2B_ENST00000343439.5_Intron|BAZ2B_ENST00000355831.2_Missense_Mutation_p.D657H|BAZ2B_ENST00000392782.1_Missense_Mutation_p.D655H	NM_013450.2	NP_038478.2	Q9UIF8	BAZ2B_HUMAN	bromodomain adjacent to zinc finger domain, 2B	657	Asp/Glu-rich (acidic).				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(7)|liver(2)|lung(41)|ovary(3)|prostate(1)|skin(2)|soft_tissue(1)|urinary_tract(1)	82						TCTGATTCATCTTGGTCTTTA	0.353000													7	46					0	0	1	0	0
RASGRF2	5924	broad.mit.edu	37	5	80256710	80256710	+	Silent	SNP	C	C	G			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr5:80256710C>G	ENST00000265080.4	+	1	220	c.153C>G	c.(151-153)ctC>ctG	p.L51L	CTC-459I6.1_ENST00000505694.1_RNA	NM_006909.2	NP_008840.1	O14827	RGRF2_HUMAN	Ras protein-specific guanine nucleotide-releasing factor 2	51	PH 1.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|synaptic transmission	cytosol|endoplasmic reticulum membrane|plasma membrane	protein binding|Rho guanyl-nucleotide exchange factor activity			biliary_tract(1)|breast(5)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(15)|lung(28)|ovary(5)|prostate(3)|skin(4)|soft_tissue(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	75		Lung NSC(167;0.00498)|all_lung(232;0.00531)|Ovarian(174;0.0357)		OV - Ovarian serous cystadenocarcinoma(54;4.22e-42)|Epithelial(54;4.04e-35)|all cancers(79;2.52e-29)		AGAATGTGCTCTTCTACTTCG	0.687000													10	26					0	0	1	0	0
ZNF443	10224	broad.mit.edu	37	19	12541736	12541736	+	Missense_Mutation	SNP	C	C	G			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr19:12541736C>G	ENST00000301547.5	-	4	1447	c.1250G>C	c.(1249-1251)gGa>gCa	p.G417A	CTD-3105H18.16_ENST00000595562.1_Intron	NM_005815.4	NP_005806	Q9Y2A4	ZN443_HUMAN	zinc finger protein 443	417					induction of apoptosis|regulation of transcription, DNA-dependent|response to stress|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(3)|endometrium(1)|kidney(1)|large_intestine(11)|lung(10)|pancreas(1)|prostate(1)	28						AGGTCCATCTCCAGTGTGCAT	0.418000													63	64					0	0	1	0	0
ZNF292	23036	broad.mit.edu	37	6	87943104	87943104	+	Missense_Mutation	SNP	C	C	G			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr6:87943104C>G	ENST00000369577.3	+	5	643	c.600C>G	c.(598-600)atC>atG	p.I200M	ZNF292_ENST00000339907.4_Missense_Mutation_p.I195M	NM_015021.1	NP_055836.1	O60281	ZN292_HUMAN	zinc finger protein 292	200					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(27)|lung(21)|ovary(4)|prostate(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	89		all_cancers(76;3.82e-09)|Prostate(29;1.34e-10)|Acute lymphoblastic leukemia(125;2.17e-10)|all_hematologic(105;1.08e-06)|all_epithelial(107;5.31e-05)		BRCA - Breast invasive adenocarcinoma(108;0.0199)		AACATCTAATCAAAACAAATC	0.328000													23	25					0	0	1	0	0
SLC25A45	283130	broad.mit.edu	37	11	65147614	65147614	+	Missense_Mutation	SNP	C	C	G			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr11:65147614C>G	ENST00000534028.1	-	2	491	c.70G>C	c.(70-72)Gac>Cac	p.D24H	SLC25A45_ENST00000527174.1_Missense_Mutation_p.D24H|SLC25A45_ENST00000417511.2_5'UTR|SLC25A45_ENST00000294187.6_5'UTR|SLC25A45_ENST00000526432.1_Missense_Mutation_p.D24H|SLC25A45_ENST00000360662.3_Missense_Mutation_p.D24H|SLC25A45_ENST00000398802.1_Missense_Mutation_p.D24H|SLC25A45_ENST00000377152.2_5'UTR	NM_001278250.1	NP_001265179.1	Q8N413	S2545_HUMAN	solute carrier family 25, member 45	24					transmembrane transport	integral to membrane|mitochondrial inner membrane	binding			endometrium(2)|kidney(3)|large_intestine(2)|lung(6)|upper_aerodigestive_tract(1)	14						TTTACAGTGTCAAACGGGTGT	0.567000													18	79					0	0	1	0	0
SYTL5	94122	broad.mit.edu	37	X	37969647	37969647	+	Missense_Mutation	SNP	G	G	A			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chrX:37969647G>A	ENST00000357972.5	+	13	2054	c.1508G>A	c.(1507-1509)cGt>cAt	p.R503H	SYTL5_ENST00000297875.2_Missense_Mutation_p.R503H|TM4SF2_ENST00000465127.1_Intron|SYTL5_ENST00000456733.2_Missense_Mutation_p.R525H			Q8TDW5	SYTL5_HUMAN	synaptotagmin-like 5	503	C2 1.				intracellular protein transport	membrane	metal ion binding|Rab GTPase binding			central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(9)|lung(23)|prostate(1)|skin(2)|urinary_tract(1)	44						CGATTTGGACGTAATAGCTTC	0.438000													3	48					0	0	1	0	0
NRXN2	9379	broad.mit.edu	37	11	64428387	64428387	+	Missense_Mutation	SNP	C	C	T			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr11:64428387C>T	ENST00000265459.6	-	10	2484	c.2023G>A	c.(2023-2025)Gag>Aag	p.E675K	NRXN2_ENST00000409571.1_Missense_Mutation_p.E668K|NRXN2_ENST00000377551.1_Missense_Mutation_p.E675K|NRXN2_ENST00000377559.3_Missense_Mutation_p.E644K|NRXN2_ENST00000496291.1_5'UTR	NM_015080.3	NP_055895.1	Q9P2S2	NRX2A_HUMAN	neurexin 2	675	Laminin G-like 3.				cell adhesion	integral to membrane	metal ion binding			breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|liver(1)|lung(34)|ovary(6)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(6)|urinary_tract(1)	71						CCCTGAGCCTCAGCCAGGCCC	0.672000													12	35					0	0	1	0	0
MYH7	4625	broad.mit.edu	37	14	23890220	23890220	+	Missense_Mutation	SNP	C	C	G			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr14:23890220C>G	ENST00000355349.3	-	26	3445	c.3283G>C	c.(3283-3285)Gag>Cag	p.E1095Q		NM_000257.2	NP_000248.2	P12883	MYH7_HUMAN	myosin, heavy chain 7, cardiac muscle, beta	1095					adult heart development|muscle filament sliding|regulation of heart rate|ventricular cardiac muscle tissue morphogenesis	focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(3)|breast(4)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(19)|lung(57)|ovary(5)|prostate(9)|skin(5)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	137	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00725)		TGTTCATCCTCAATCCTTGCG	0.587000													24	4					0	0	1	0	0
ZNF566	84924	broad.mit.edu	37	19	36964275	36964275	+	Missense_Mutation	SNP	C	C	T			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr19:36964275C>T	ENST00000454319.1	-	3	229	c.95G>A	c.(94-96)aGa>aAa	p.R32K	ZNF566_ENST00000472909.2_Intron|ZNF566_ENST00000424129.2_Missense_Mutation_p.R32K|ZNF566_ENST00000392170.2_Missense_Mutation_p.R32K|ZNF566_ENST00000434377.2_Missense_Mutation_p.R32K|ZNF566_ENST00000493391.1_Intron	NM_001145343.1|NM_001145344.1|NM_001145345.1	NP_001138815.1|NP_001138816.1|NP_001138817.1	Q969W8	ZN566_HUMAN	zinc finger protein 566	32	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(3)|kidney(2)|large_intestine(2)|lung(12)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	24	Esophageal squamous(110;0.162)					CATCACATCTCTGTATAAATC	0.438000													13	52					0	0	1	0	0
VAMP2	6844	broad.mit.edu	37	17	8065084	8065084	+	Translation_Start_Site	SNP	C	C	T			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr17:8065084C>T	ENST00000404970.3	-	0	201				VAMP2_ENST00000316509.6_Splice_Site_p.V42M|VAMP2_ENST00000488857.1_Splice_Site_p.V44M|VAMP2_ENST00000481878.1_Splice_Site_p.V42M|RP11-599B13.6_ENST00000498285.1_Splice_Site_p.V42M			P63027	VAMP2_HUMAN	vesicle-associated membrane protein 2 (synaptobrevin 2)						energy reserve metabolic process|glutamate secretion|post-Golgi vesicle-mediated transport|regulation of insulin secretion	cell junction|clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|clathrin sculpted glutamate transport vesicle membrane|clathrin sculpted monoamine transport vesicle membrane|endocytic vesicle membrane|integral to plasma membrane|synaptic vesicle membrane|synaptosome										Botulinum Toxin Type B(DB00042)	ATGTCCACCACCTGGGAGAAG	0.632000													22	14					0	0	1	0	0
MUC15	143662	broad.mit.edu	37	11	26587129	26587129	+	Missense_Mutation	SNP	C	C	G			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr11:26587129C>G	ENST00000436318.2	-	2	491	c.358G>C	c.(358-360)Gca>Cca	p.A120P	ANO3_ENST00000537978.1_Intron|ANO3_ENST00000525139.1_Intron|MUC15_ENST00000529533.1_Missense_Mutation_p.A120P|MUC15_ENST00000527569.1_Missense_Mutation_p.A120P|MUC15_ENST00000281268.8_Missense_Mutation_p.A120P|ANO3_ENST00000256737.3_Intron|MUC15_ENST00000455601.2_Missense_Mutation_p.A93P|ANO3_ENST00000531568.1_Intron			Q8N387	MUC15_HUMAN	mucin 15, cell surface associated	93						extracellular region|integral to membrane|plasma membrane				breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(5)|lung(7)|ovary(1)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	25						GAATGCTCTGCTGATGAGTTA	0.438000													37	20					0	0	1	0	0
SHCBP1	79801	broad.mit.edu	37	16	46642219	46642219	+	Silent	SNP	G	G	T			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr16:46642219G>T	ENST00000303383.3	-	5	945	c.679C>A	c.(679-681)Cga>Aga	p.R227R		NM_024745.4	NP_079021	Q8NEM2	SHCBP_HUMAN	SHC SH2-domain binding protein 1	227										breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(7)|ovary(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	28		all_cancers(37;0.00404)|all_epithelial(9;0.00527)|all_lung(18;0.0413)|Lung NSC(13;0.213)				AATCTTAATCGAGGTTCAACA	0.358000													4	24					0.014758	0.0147875	1	1	0
EIF3B	8662	broad.mit.edu	37	7	2402753	2402753	+	Silent	SNP	C	C	T			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr7:2402753C>T	ENST00000360876.4	+	4	917	c.861C>T	c.(859-861)ttC>ttT	p.F287F	EIF3B_ENST00000397011.2_Silent_p.F287F	NM_001037283.1	NP_001032360.1	P55884	EIF3B_HUMAN	eukaryotic translation initiation factor 3, subunit B	287	Sufficient for interaction with EIF3E.				regulation of translational initiation	cytosol|eukaryotic translation initiation factor 3 complex	nucleotide binding|protein complex scaffold|translation initiation factor activity			breast(2)|endometrium(4)|kidney(2)|large_intestine(3)|lung(11)|ovary(1)|skin(1)	24		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0833)|OV - Ovarian serous cystadenocarcinoma(56;7.76e-14)		AACAGCCTTTCAAAGACCTGG	0.517000													41	174					0	0	1	0	0
TNS4	84951	broad.mit.edu	37	17	38637000	38637000	+	Missense_Mutation	SNP	C	C	A			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr17:38637000C>A	ENST00000254051.6	-	9	1851	c.1693G>T	c.(1693-1695)Gcc>Tcc	p.A565S		NM_032865.5	NP_116254.4	Q8IZW8	TENS4_HUMAN	tensin 4	565	Phosphatase tensin-type.				apoptosis|protein localization	cytoplasm|cytoskeleton|focal adhesion	actin binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(3)|ovary(2)|prostate(2)|skin(10)|upper_aerodigestive_tract(1)	30		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(5;5.91e-05)			GAGTCCGAGGCCCCATCTGCA	0.617000													11	39					0.00010058	0.000102212	1	1	0
CCDC36	339834	broad.mit.edu	37	3	49292905	49292905	+	Missense_Mutation	SNP	G	G	C			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr3:49292905G>C	ENST00000438782.1	+	7	851	c.615G>C	c.(613-615)gaG>gaC	p.E205D	CCDC36_ENST00000296449.5_Missense_Mutation_p.E205D|CCDC36_ENST00000452691.2_Missense_Mutation_p.E205D			Q8IYA8	CCD36_HUMAN	coiled-coil domain containing 36	205										endometrium(1)|kidney(2)|large_intestine(3)|liver(1)|lung(3)|ovary(1)|urinary_tract(3)	14				BRCA - Breast invasive adenocarcinoma(193;9.11e-05)|Kidney(197;0.00248)|KIRC - Kidney renal clear cell carcinoma(197;0.00262)		CCATCCTTGAGATGAAGAAAA	0.408000													30	57					0	0	1	0	0
C10orf2	56652	broad.mit.edu	37	10	102747984	102747984	+	Missense_Mutation	SNP	G	G	A			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr10:102747984G>A	ENST00000370228.1	+	1	202	c.17G>A	c.(16-18)cGa>cAa	p.R6Q	C10orf2_ENST00000311916.2_Missense_Mutation_p.R6Q|C10orf2_ENST00000473656.1_Intron	NM_001163812.1|NM_001163814.1	NP_001157284.1|NP_001157286.1	Q96RR1	PEO1_HUMAN	chromosome 10 open reading frame 2	6					cell death|mitochondrial DNA replication|protein hexamerization|protein homooligomerization|transcription from mitochondrial promoter	mitochondrial nucleoid	5'-3' DNA helicase activity|ATP binding|protease binding|single-stranded DNA binding			breast(3)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(10)|ovary(1)|skin(1)|stomach(1)	24		Colorectal(252;0.122)|all_hematologic(284;0.152)		Epithelial(162;7.18e-11)|all cancers(201;8.75e-09)|BRCA - Breast invasive adenocarcinoma(275;0.224)		GTCCTCCTCCGAAGTGGGTAC	0.582000													23	56					0	0	1	0	0
ZP1	22917	broad.mit.edu	37	11	60642417	60642417	+	Missense_Mutation	SNP	C	C	G			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr11:60642417C>G	ENST00000278853.5	+	10	1584	c.1584C>G	c.(1582-1584)ttC>ttG	p.F528L		NM_207341.2	NP_997224.2	P60852	ZP1_HUMAN	zona pellucida glycoprotein 1 (sperm receptor)	528	ZP.				single fertilization	integral to membrane|plasma membrane|proteinaceous extracellular matrix				breast(3)|endometrium(2)|large_intestine(8)|lung(8)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	26						TTTACTTGTTCTGCAGCACCT	0.557000													23	60					0	0	1	0	0
SLK	9748	broad.mit.edu	37	10	105758909	105758909	+	Missense_Mutation	SNP	C	C	T			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr10:105758909C>T	ENST00000369755.3	+	6	1165	c.620C>T	c.(619-621)tCt>tTt	p.S207F	SLK_ENST00000335753.4_Missense_Mutation_p.S207F	NM_014720.2	NP_055535.2	Q9H2G2	SLK_HUMAN	STE20-like kinase	207	Protein kinase.				apoptosis|nucleotide-excision repair	cytoplasm|plasma membrane	ATP binding|DNA binding|nuclease activity|protein serine/threonine kinase activity			kidney(1)|lung(1)|ovary(2)|skin(2)|stomach(2)	8		Colorectal(252;0.178)		Epithelial(162;5.81e-10)|all cancers(201;2.35e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0165)		TGTGAAACATCTAAGGACAGA	0.368000													17	24					0	0	1	0	0
FBXW12	285231	broad.mit.edu	37	3	48423353	48423353	+	Silent	SNP	C	C	T			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr3:48423353C>T	ENST00000296438.5	+	9	1335	c.1149C>T	c.(1147-1149)atC>atT	p.I383I	FBXW12_ENST00000445170.1_Silent_p.I364I|FBXW12_ENST00000468158.1_3'UTR|FBXW12_ENST00000436231.1_Silent_p.I226I|FBXW12_ENST00000415155.1_Silent_p.I313I	NM_207102.2	NP_996985.2	Q6X9E4	FBW12_HUMAN	F-box and WD repeat domain containing 12	383										breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(5)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	16				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		AGGCAGCCATCAACAACTTCT	0.468000													32	51					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179639711	179639711	+	Missense_Mutation	SNP	C	C	G	rs138787974	byFrequency	TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr2:179639711C>G	ENST00000589042.1	-	29	6951	c.6727G>C	c.(6727-6729)Gat>Cat	p.D2243H	TTN_ENST00000342175.6_Missense_Mutation_p.D2197H|TTN_ENST00000591111.1_Missense_Mutation_p.D2243H|TTN_ENST00000342992.6_Missense_Mutation_p.D2243H|TTN_ENST00000359218.5_Missense_Mutation_p.D2197H|TTN_ENST00000360870.5_Missense_Mutation_p.D2243H|TTN_ENST00000460472.2_Missense_Mutation_p.D2197H	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	1974	Ig-like 11.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CAGCTGTAATCTTCAGCATCA	0.398000													15	23					0	0	1	0	0
SETD2	29072	broad.mit.edu	37	3	47163029	47163029	+	Missense_Mutation	SNP	T	T	C	rs145759179	byFrequency	TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr3:47163029T>C	ENST00000409792.3	-	3	3139	c.3097A>G	c.(3097-3099)Aca>Gca	p.T1033A		NM_014159.6	NP_054878.5	Q9BYW2	SETD2_HUMAN	SET domain containing 2	1033					regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	DNA binding|histone-lysine N-methyltransferase activity|oxidoreductase activity|transition metal ion binding			breast(6)|central_nervous_system(5)|endometrium(4)|kidney(63)|large_intestine(18)|lung(26)|ovary(6)|prostate(2)|skin(3)|soft_tissue(1)|stomach(2)|urinary_tract(5)	141		Acute lymphoblastic leukemia(5;0.0169)		BRCA - Breast invasive adenocarcinoma(193;0.000302)|KIRC - Kidney renal clear cell carcinoma(197;0.00732)|Kidney(197;0.00844)		TCATGAACTGTAGACACAATT	0.368000			"""N, F, S, Mis"""		clear cell renal carcinoma								45	52					0	0	1	0	0
FOXM1	2305	broad.mit.edu	37	12	2968224	2968224	+	Missense_Mutation	SNP	C	C	A			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr12:2968224C>A	ENST00000342628.2	-	10	2099	c.1986G>T	c.(1984-1986)tgG>tgT	p.W662C	FOXM1_ENST00000361953.3_Missense_Mutation_p.W609C|FOXM1_ENST00000359843.3_Missense_Mutation_p.W624C|ITFG2_ENST00000545509.1_Intron	NM_202002.2	NP_973731.1	Q08050	FOXM1_HUMAN	forkhead box M1	624					cell cycle|embryo development|liver development|negative regulation of cell aging|negative regulation of stress-activated MAPK cascade|negative regulation of transcription from RNA polymerase II promoter|pattern specification process|positive regulation of cell proliferation|positive regulation of transcription from RNA polymerase II promoter|regulation of cell cycle arrest|regulation of cell growth|regulation of cell proliferation|regulation of oxygen and reactive oxygen species metabolic process|regulation of Ras protein signal transduction|regulation of reactive oxygen species metabolic process|regulation of sequence-specific DNA binding transcription factor activity|tissue development|transcription from RNA polymerase II promoter|vasculogenesis	cytoplasm|transcription factor complex	DNA bending activity|DNA binding|double-stranded DNA binding|promoter binding|protein binding|protein domain specific binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|transcription factor binding			breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(7)|lung(9)|prostate(1)|skin(1)|urinary_tract(3)	24			OV - Ovarian serous cystadenocarcinoma(31;0.000622)			GCGTGAGCCTCCAGGATTCAG	0.602000													28	89					4.22769e-11	4.48745e-11	1	1	0
CXorf66	347487	broad.mit.edu	37	X	139038362	139038362	+	Missense_Mutation	SNP	G	G	C			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chrX:139038362G>C	ENST00000370540.1	-	3	802	c.779C>G	c.(778-780)tCt>tGt	p.S260C		NM_001013403.2	NP_001013421.1	Q5JRM2	CX066_HUMAN	chromosome X open reading frame 66	260						integral to membrane				breast(1)|endometrium(2)|kidney(3)|large_intestine(5)|lung(13)|skin(1)|stomach(1)	26						AGCTAATTCAGAGTTGGATAA	0.418000													55	12					0	0	1	0	0
F13A1	2162	broad.mit.edu	37	6	6248606	6248606	+	Missense_Mutation	SNP	G	G	A			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr6:6248606G>A	ENST00000264870.3	-	6	1002	c.737C>T	c.(736-738)gCa>gTa	p.A246V		NM_000129.3	NP_000120.2	P00488	F13A_HUMAN	coagulation factor XIII, A1 polypeptide	246					peptide cross-linking|platelet activation|platelet degranulation	extracellular region|platelet alpha granule lumen	acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(37)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	62	Ovarian(93;0.0816)	all_hematologic(90;0.152)			L-Glutamine(DB00130)	GTCCATTTGTGCTCTGTCCAT	0.433000													9	20					0	0	1	0	0
STK32B	55351	broad.mit.edu	37	4	5418605	5418605	+	Missense_Mutation	SNP	C	C	T	rs139253606	byFrequency	TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr4:5418605C>T	ENST00000282908.5	+	6	928	c.506C>T	c.(505-507)aCg>aTg	p.T169M	STK32B_ENST00000512636.1_Intron|STK32B_ENST00000510398.1_Missense_Mutation_p.T122M	NM_018401.1	NP_060871.1	Q9NY57	ST32B_HUMAN	serine/threonine kinase 32B	169	Protein kinase.						ATP binding|metal ion binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(10)|lung(16)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)	39						AACATAGCGACGGTAGTGAAA	0.507000													8	28					0	0	1	0	0
ARSG	22901	broad.mit.edu	37	17	66366605	66366605	+	Nonsense_Mutation	SNP	C	C	T			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr17:66366605C>T	ENST00000448504.2	+	8	1718	c.922C>T	c.(922-924)Cag>Tag	p.Q308*	ARSG_ENST00000582154.1_3'UTR|ARSG_ENST00000452479.2_Nonsense_Mutation_p.Q144*	NM_014960.4	NP_055775.2	Q96EG1	ARSG_HUMAN	arylsulfatase G	308					sulfur compound metabolic process	endoplasmic reticulum|extracellular space|lysosome	arylsulfatase activity|metal ion binding			NS(2)|endometrium(3)|kidney(1)|large_intestine(8)|lung(8)|ovary(1)|prostate(1)|stomach(1)|urinary_tract(1)	26			BRCA - Breast invasive adenocarcinoma(8;5.34e-07)|LUSC - Lung squamous cell carcinoma(166;0.24)			CCCGTGGGCTCAGAAGTGTGA	0.547000													36	16					0	0	1	0	0
CSTF2T	23283	broad.mit.edu	37	10	53459240	53459240	+	Missense_Mutation	SNP	G	G	A			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr10:53459240G>A	ENST00000331173.4	-	1	115	c.70C>T	c.(70-72)Cca>Tca	p.P24S	PRKG1_ENST00000373980.4_Intron|PRKG1_ENST00000401604.2_Intron|PRKG1_ENST00000373985.1_Intron	NM_015235.2	NP_056050.1	Q9H0L4	CSTFT_HUMAN	cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa, tau variant	24	RRM.				mRNA processing	nucleus	nucleotide binding|RNA binding			NS(1)|breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(8)|lung(6)|ovary(1)|prostate(2)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	30				COAD - Colon adenocarcinoma(2;0.00736)|Colorectal(2;0.00898)|all cancers(4;0.0188)|GBM - Glioblastoma multiforme(4;0.0778)|Epithelial(53;0.122)		GCCTCATATGGAATGTTCCCC	0.517000													79	50					0	0	1	0	0
LTBP1	4052	broad.mit.edu	37	2	33614363	33614363	+	Silent	SNP	C	C	T			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr2:33614363C>T	ENST00000404816.2	+	32	5177	c.4824C>T	c.(4822-4824)ttC>ttT	p.F1608F	LTBP1_ENST00000354476.3_Silent_p.F1609F|LTBP1_ENST00000407925.1_Silent_p.F1282F|LTBP1_ENST00000390003.4_Silent_p.F1283F|LTBP1_ENST00000272273.5_Silent_p.F506F|LTBP1_ENST00000418533.2_Silent_p.F1240F|LTBP1_ENST00000404525.1_Silent_p.F1229F|LTBP1_ENST00000402934.1_Silent_p.F1227F			Q14766	LTBP1_HUMAN	latent transforming growth factor beta binding protein 1	1608					negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta	proteinaceous extracellular matrix	calcium ion binding|growth factor binding|transforming growth factor beta receptor activity			breast(2)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(13)|lung(60)|ovary(4)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(3)	108	all_hematologic(175;0.115)	Medulloblastoma(90;0.215)				ATCCCTACTTCATCCAAGACC	0.463000													51	59					0	0	1	0	0
OBSCN	84033	broad.mit.edu	37	1	228524792	228524792	+	Missense_Mutation	SNP	A	A	G			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr1:228524792A>G	ENST00000570156.2	+	76	19570	c.19496A>G	c.(19495-19497)cAg>cGg	p.Q6499R	OBSCN_ENST00000366707.4_Missense_Mutation_p.Q3176R|OBSCN_ENST00000284548.11_Missense_Mutation_p.Q5542R|OBSCN_ENST00000422127.1_Missense_Mutation_p.Q5542R|OBSCN_ENST00000366709.4_Missense_Mutation_p.Q2661R	NM_001271223.2	NP_001258152.2	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	5542	Protein kinase 1.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			NS(2)|breast(7)|central_nervous_system(5)|cervix(2)|endometrium(30)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(37)|lung(89)|ovary(8)|pancreas(3)|prostate(13)|skin(6)|stomach(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	223		Prostate(94;0.0405)				CTGACCTCCCAGATCACTGAG	0.622000													40	6					0	0	1	0	0
SEC14L1	6397	broad.mit.edu	37	17	75208187	75208187	+	Silent	SNP	G	G	A	rs139177480		TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr17:75208187G>A	ENST00000413679.2	+	15	2070	c.1767G>A	c.(1765-1767)ggG>ggA	p.G589G	SEC14L1_ENST00000430767.4_Silent_p.G589G|SEC14L1_ENST00000431431.2_Silent_p.G555G|SEC14L1_ENST00000443798.4_Silent_p.G589G|SEC14L1_ENST00000591437.1_Silent_p.G555G|SEC14L1_ENST00000392476.2_Silent_p.G589G|SEC14L1_ENST00000436233.4_Silent_p.G589G|SEC14L1_ENST00000585618.1_Silent_p.G589G	NM_001143998.1|NM_001143999.1|NM_003003.3	NP_001137470|NP_001137471|NP_002994	Q92503	S14L1_HUMAN	SEC14-like 1 (S. cerevisiae)	589	GOLD.				transport	Golgi apparatus|integral to membrane	binding			NS(1)|endometrium(4)|kidney(3)|large_intestine(4)|lung(12)|ovary(3)|prostate(2)|skin(2)	31						CTCCGGGTGGGAACAATGTGC	0.542000													92	285					0	0	1	0	0
KCTD3	51133	broad.mit.edu	37	1	215749295	215749295	+	Missense_Mutation	SNP	C	C	G			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr1:215749295C>G	ENST00000259154.4	+	4	529	c.235C>G	c.(235-237)Cgg>Ggg	p.R79G		NM_016121.3	NP_057205.2	Q9Y597	KCTD3_HUMAN	potassium channel tetramerization domain containing 3	79	BTB.					voltage-gated potassium channel complex	protein binding|voltage-gated potassium channel activity			breast(4)|endometrium(2)|kidney(1)|large_intestine(5)|lung(16)|ovary(3)|prostate(1)|skin(1)	33				all cancers(67;0.0164)|OV - Ovarian serous cystadenocarcinoma(81;0.019)|GBM - Glioblastoma multiforme(131;0.0862)|Epithelial(68;0.13)		AAATTTTCTTCGGACAAAAGA	0.244000													7	13					0	0	1	0	0
UBN2	254048	broad.mit.edu	37	7	138968209	138968209	+	Missense_Mutation	SNP	C	C	G			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr7:138968209C>G	ENST00000473989.3	+	15	2558	c.2558C>G	c.(2557-2559)tCt>tGt	p.S853C	UBN2_ENST00000288561.8_Missense_Mutation_p.S770C	NM_173569.3	NP_775840.3	Q6ZU65	UBN2_HUMAN	ubinuclein 2											NS(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(5)|large_intestine(7)|lung(16)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(1)	42						ACTGGCATCTCTTCAGGCCTT	0.448000													24	58					0	0	1	0	0
NPHP3	27031	broad.mit.edu	37	3	132407671	132407671	+	Missense_Mutation	SNP	C	C	A			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr3:132407671C>A	ENST00000337331.5	-	21	3034	c.2948G>T	c.(2947-2949)aGa>aTa	p.R983I	NPHP3_ENST00000326682.8_3'UTR	NM_153240.4	NP_694972.3	Q7Z494	NPHP3_HUMAN	nephronophthisis 3 (adolescent)	983					maintenance of organ identity|negative regulation of canonical Wnt receptor signaling pathway|photoreceptor cell maintenance|regulation of Wnt receptor signaling pathway, planar cell polarity pathway|Wnt receptor signaling pathway	cilium	protein binding			NS(1)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(5)|lung(15)|ovary(2)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	42						CTGGGCTACTCTTGGGTGATC	0.473000													22	86					1.64293e-13	1.76255e-13	1	1	0
SMIM11	54065	broad.mit.edu	37	21	35757939	35757939	+	Nonstop_Mutation	SNP	G	G	T			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr21:35757939G>T	ENST00000399295.2	+	3	546	c.176G>T	c.(175-177)tGa>tTa	p.*59L	SMIM11_ENST00000481710.1_3'UTR|SMIM11_ENST00000399299.1_Intron|SMIM11_ENST00000399292.3_Nonstop_Mutation_p.*59L					small integral membrane protein 11																		AAAGATAACTGAAGGTGAGTC	0.463000													12	22					0.000151284	0.000153428	1	1	0
CNTN4	152330	broad.mit.edu	37	3	3072565	3072565	+	Silent	SNP	C	C	T			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr3:3072565C>T	ENST00000397461.1	+	15	2073	c.1689C>T	c.(1687-1689)atC>atT	p.I563I	CNTN4_ENST00000397459.2_Silent_p.I235I|CNTN4_ENST00000448906.2_Silent_p.I235I|CNTN4_ENST00000418658.1_Silent_p.I563I|CNTN4_ENST00000427331.1_Silent_p.I563I|CNTN4_ENST00000358480.3_Silent_p.I344I	NM_001206955.1	NP_001193884.1	Q8IWV2	CNTN4_HUMAN	contactin 4	563	Ig-like C2-type 6.				axon guidance|axonal fasciculation|brain development|negative regulation of neuron differentiation|neuron cell-cell adhesion|regulation of synaptic plasticity	anchored to membrane|axon|extracellular region|plasma membrane	protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(14)|lung(19)|ovary(2)|pancreas(4)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	61		Ovarian(110;0.156)		Epithelial(13;0.000695)|all cancers(10;0.0047)|OV - Ovarian serous cystadenocarcinoma(96;0.01)		ATTTGATGATCCGAAACATCC	0.433000													10	55					0	0	1	0	0
POTEE	445582	broad.mit.edu	37	2	131976312	131976312	+	Missense_Mutation	SNP	G	G	A			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr2:131976312G>A	ENST00000356920.5	+	1	431	c.337G>A	c.(337-339)Ggc>Agc	p.G113S	POTEE_ENST00000358087.5_Missense_Mutation_p.G113S|PLEKHB2_ENST00000303908.3_Intron|PLEKHB2_ENST00000404460.1_Intron	NM_001083538.1	NP_001077007.1	Q6S8J3	POTEE_HUMAN	POTE ankyrin domain family, member E	113							ATP binding										CAGGGGGAGCGGCAAGAGCAA	0.607000													6	110					0	0	1	0	0
PITX3	5309	broad.mit.edu	37	10	103991526	103991526	+	Missense_Mutation	SNP	G	G	A			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr10:103991526G>A	ENST00000370002.3	-	3	293	c.140C>T	c.(139-141)tCg>tTg	p.S47L	PITX3_ENST00000539804.1_Missense_Mutation_p.S47L	NM_005029.3	NP_005020.1	O75364	PITX3_HUMAN	paired-like homeodomain 3	47					dopaminergic neuron differentiation|lens morphogenesis in camera-type eye|midbrain development|positive regulation of transcription, DNA-dependent	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(1)|large_intestine(2)|lung(2)	5		Colorectal(252;0.00957)		Epithelial(162;4.97e-08)|all cancers(201;8.99e-07)		GCCGGGCAGCGAAGCCGAGGC	0.662000													3	8					0	0	1	0	0
UGT1A5	54579	broad.mit.edu	37	2	234622085	234622085	+	Silent	SNP	C	C	T	rs28946886		TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr2:234622085C>T	ENST00000373414.3	+	1	448	c.448C>T	c.(448-450)Cta>Tta	p.L150L	UGT1A7_ENST00000373426.3_Intron|UGT1A6_ENST00000305139.6_Intron|UGT1A1_ENST00000609637.1_Intron|UGT1A10_ENST00000344644.5_Intron|UGT1A6_ENST00000480628.1_Intron|UGT1A6_ENST00000373424.1_Intron|UGT1A10_ENST00000373445.1_Intron|UGT1A1_ENST00000373450.4_Intron|UGT1A6_ENST00000406651.1_Intron|UGT1A1_ENST00000608381.1_Silent_p.L150L|UGT1A9_ENST00000354728.4_Intron																cervix(1)|endometrium(3)|large_intestine(4)|lung(9)|ovary(1)|skin(3)|urinary_tract(1)	22		Breast(86;0.000765)|all_lung(227;0.00267)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0328)|Lung NSC(271;0.0457)|Lung SC(224;0.128)		Epithelial(121;4.51e-18)|BRCA - Breast invasive adenocarcinoma(100;0.000523)|Lung(119;0.00271)|LUSC - Lung squamous cell carcinoma(224;0.00645)		TGATGTGGTTCTAACAGACCC	0.453000													55	90					0	0	1	0	0
SPATA31E1	286234	broad.mit.edu	37	9	90503512	90503512	+	Silent	SNP	A	A	G			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr9:90503512A>G	ENST00000325643.5	+	4	4176	c.4110A>G	c.(4108-4110)agA>agG	p.R1370R		NM_178828.4	NP_849150.3			SPATA31 subfamily E, member 1																		AACGTAGCAGAGAGATGAGAG	0.597000													25	38					0	0	1	0	0
CNTNAP3	79937	broad.mit.edu	37	9	39086769	39086769	+	Missense_Mutation	SNP	C	C	G			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr9:39086769C>G	ENST00000297668.6	-	20	3371	c.3298G>C	c.(3298-3300)Gat>Cat	p.D1100H	CNTNAP3_ENST00000358144.2_Missense_Mutation_p.D1012H|CNTNAP3_ENST00000377656.2_Missense_Mutation_p.D1019H	NM_033655.3	NP_387504.2	Q9BZ76	CNTP3_HUMAN	contactin associated protein-like 3	1100	Laminin G-like 4.				cell adhesion|cell recognition|signal transduction	extracellular region|integral to membrane|plasma membrane	receptor binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(5)|liver(2)|lung(8)|ovary(1)|upper_aerodigestive_tract(2)	24				GBM - Glioblastoma multiforme(29;0.02)|Lung(182;0.0681)		AGTTGCCCATCAGCCATGTTT	0.338000													3	12					0	0	1	0	0
PWP2	5822	broad.mit.edu	37	21	45547985	45547985	+	Missense_Mutation	SNP	G	G	C			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr21:45547985G>C	ENST00000291576.7	+	18	2440	c.2313G>C	c.(2311-2313)gaG>gaC	p.E771D	PWP2_ENST00000494310.1_3'UTR	NM_005049.2	NP_005040.2	Q15269	PWP2_HUMAN	PWP2 periodic tryptophan protein homolog (yeast)	771						cytoplasm|nucleolus	signal transducer activity			cervix(1)|endometrium(6)|large_intestine(6)|lung(4)|pancreas(1)|prostate(1)|stomach(1)|urinary_tract(1)	21				STAD - Stomach adenocarcinoma(101;0.172)|Colorectal(79;0.2)		GGCTCAACGAGAGCAAACTGG	0.677000													18	17					0	0	1	0	0
BTBD1	53339	broad.mit.edu	37	15	83735855	83735855	+	Missense_Mutation	SNP	C	C	T			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr15:83735855C>T	ENST00000261721.4	-	1	251	c.49G>A	c.(49-51)Gag>Aag	p.E17K	BTBD1_ENST00000379403.2_Missense_Mutation_p.E17K|RP11-382A20.5_ENST00000566841.1_RNA|RP11-382A20.6_ENST00000568441.1_RNA	NM_001011885.1|NM_025238.3	NP_001011885.1|NP_079514.1	Q9H0C5	BTBD1_HUMAN	BTB (POZ) domain containing 1	17						cytoplasmic mRNA processing body|protein complex	protein binding			central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(2)|ovary(1)|prostate(1)	10				all cancers(203;0.000186)		ggcTCCGCCTCAGCCCCCGAC	0.741000													5	1					0	0	1	0	0
CCDC97	90324	broad.mit.edu	37	19	41825733	41825733	+	Missense_Mutation	SNP	G	G	C			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr19:41825733G>C	ENST00000269967.3	+	3	879	c.757G>C	c.(757-759)Gag>Cag	p.E253Q		NM_052848.1	NP_443080.1	Q96F63	CCD97_HUMAN	coiled-coil domain containing 97	253								p.E253K(1)		biliary_tract(1)|central_nervous_system(2)|endometrium(3)|kidney(1)|large_intestine(4)|lung(6)	17						ggaagaggaagaggaggagga	0.607000													8	11					0	0	1	0	0
MFSD11	79157	broad.mit.edu	37	17	74740463	74740463	+	Missense_Mutation	SNP	C	C	G			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr17:74740463C>G	ENST00000588460.1	+	7	2598	c.556C>G	c.(556-558)Cta>Gta	p.L186V	MFSD11_ENST00000355954.3_Missense_Mutation_p.L134V|MFSD11_ENST00000593181.1_Missense_Mutation_p.L134V|MFSD11_ENST00000586622.1_Missense_Mutation_p.L186V|MFSD11_ENST00000590514.1_Missense_Mutation_p.L186V|MFSD11_ENST00000336509.4_Missense_Mutation_p.L186V	NM_001242534.1	NP_001229463.1	O43934	MFS11_HUMAN	major facilitator superfamily domain containing 11	186						integral to membrane				endometrium(1)|kidney(2)|large_intestine(3)|lung(7)|ovary(2)|prostate(1)|skin(1)	17						GGGGACAGTTCTATTCTTTCT	0.418000													21	47					0	0	1	0	0
ANKRD35	148741	broad.mit.edu	37	1	145558885	145558885	+	Missense_Mutation	SNP	C	C	G			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr1:145558885C>G	ENST00000355594.4	+	7	591	c.504C>G	c.(502-504)atC>atG	p.I168M	ANKRD35_ENST00000544626.1_3'UTR	NM_144698.3	NP_653299.4	Q8N283	ANR35_HUMAN	ankyrin repeat domain 35	168								p.I168M(1)		NS(1)|biliary_tract(1)|central_nervous_system(1)|endometrium(7)|kidney(2)|large_intestine(9)|lung(16)|ovary(4)|prostate(3)|skin(2)|urinary_tract(1)	47	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					ACGCAGCTATCTGCTCACAGC	0.572000													24	545					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179643809	179643809	+	Missense_Mutation	SNP	C	C	T			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr2:179643809C>T	ENST00000589042.1	-	24	4224	c.4000G>A	c.(4000-4002)Gga>Aga	p.G1334R	TTN_ENST00000342175.6_Missense_Mutation_p.G1288R|TTN_ENST00000591111.1_Missense_Mutation_p.G1334R|TTN_ENST00000342992.6_Missense_Mutation_p.G1334R|RP11-88L24.4_ENST00000582038.2_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.G1288R|TTN_ENST00000360870.5_Missense_Mutation_p.G1334R|TTN_ENST00000460472.2_Missense_Mutation_p.G1288R	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	1334	Ig-like 5.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TATCTTTCTCCATGTTTGATG	0.368000													20	15					0	0	1	0	0
CDH11	1009	broad.mit.edu	37	16	64981652	64981652	+	Missense_Mutation	SNP	C	C	A			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr16:64981652C>A	ENST00000268603.4	-	13	2860	c.2245G>T	c.(2245-2247)Ggc>Tgc	p.G749C	CDH11_ENST00000394156.3_3'UTR|CDH11_ENST00000566827.1_Missense_Mutation_p.G623C	NM_001797.2	NP_001788.2	P55287	CAD11_HUMAN	cadherin 11, type 2, OB-cadherin (osteoblast)	749					adherens junction organization|cell junction assembly|homophilic cell adhesion|ossification|skeletal system development	integral to membrane|plasma membrane	calcium ion binding|protein binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(5)|kidney(5)|large_intestine(19)|lung(40)|ovary(3)|prostate(3)|skin(2)|urinary_tract(2)	88		Ovarian(137;0.0973)		OV - Ovarian serous cystadenocarcinoma(108;0.205)		GCCACTGAGCCCCTGCCTTCA	0.507000			T	USP6	aneurysmal bone cysts					TSP Lung(24;0.17)			40	66					9.14704e-12	9.75036e-12	1	1	0
OTOP3	347741	broad.mit.edu	37	17	72945380	72945380	+	Missense_Mutation	SNP	G	G	C			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr17:72945380G>C	ENST00000328801.4	+	7	1660	c.1660G>C	c.(1660-1662)Gag>Cag	p.E554Q		NM_178233.1	NP_839947.1	Q7RTS5	OTOP3_HUMAN	otopetrin 3	554						integral to membrane|intracellular	zinc ion binding			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(5)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	23	all_lung(278;0.151)|Lung NSC(278;0.185)					CCCGGAGTTTGAGAACGGGCT	0.557000													14	93					0	0	1	0	0
CERS4	79603	broad.mit.edu	37	19	8326714	8326714	+	Missense_Mutation	SNP	A	A	T			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr19:8326714A>T	ENST00000558331.1	+	11	1297	c.838A>T	c.(838-840)Atg>Ttg	p.M280L	CERS4_ENST00000559336.1_Intron|CERS4_ENST00000559450.1_Missense_Mutation_p.M331L|CERS4_ENST00000251363.5_Missense_Mutation_p.M331L|CERS4_ENST00000595722.1_3'UTR			Q9HA82	CERS4_HUMAN	ceramide synthase 4	331	TLC.					endoplasmic reticulum membrane|integral to membrane|nuclear membrane	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|sphingosine N-acyltransferase activity										CTATAGCTTCATGAAGAAGGG	0.582000													11	43					0	0	1	0	0
KMT2D	8085	broad.mit.edu	37	12	49425704	49425704	+	Nonsense_Mutation	SNP	G	G	A			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr12:49425704G>A	ENST00000301067.7	-	39	12783	c.12784C>T	c.(12784-12786)Caa>Taa	p.Q4262*		NM_003482.3	NP_003473.3			lysine (K)-specific methyltransferase 2D																		CCCCCAAGTTGAGGTTGGCAG	0.706000													8	50					0	0	1	0	0
PRR5	55615	broad.mit.edu	37	22	45121151	45121151	+	Silent	SNP	C	C	T			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr22:45121151C>T	ENST00000403581.1	+	5	921	c.312C>T	c.(310-312)tcC>tcT	p.S104S	PRR5_ENST00000477331.1_Intron|ARHGAP8_ENST00000389773.5_Silent_p.S72S|PRR5-ARHGAP8_ENST00000352766.7_Silent_p.S81S|PRR5_ENST00000336985.6_Silent_p.S81S|PRR5_ENST00000006251.7_Silent_p.S72S|PRR5-ARHGAP8_ENST00000361473.5_Silent_p.S81S|ARHGAP8_ENST00000517296.3_Silent_p.S81S	NM_001198721.1	NP_001185650.1			proline rich 5 (renal)											central_nervous_system(1)|endometrium(2)|lung(6)|prostate(1)|skin(1)	11		all_neural(38;0.00409)|Ovarian(80;0.024)|Glioma(61;0.0647)		UCEC - Uterine corpus endometrioid carcinoma (28;0.168)		AGCTGGGGTCCTTCTTCACGG	0.647000													3	52					0	0	1	0	0
KIAA1468	57614	broad.mit.edu	37	18	59942679	59942679	+	Silent	SNP	G	G	A			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr18:59942679G>A	ENST00000256858.6	+	23	3290	c.3042G>A	c.(3040-3042)gtG>gtA	p.V1014V	KIAA1468_ENST00000398130.2_Silent_p.V980V			Q9P260	K1468_HUMAN	KIAA1468	980							binding			autonomic_ganglia(1)|breast(4)|endometrium(4)|kidney(4)|large_intestine(7)|lung(20)|ovary(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	47		Colorectal(73;0.186)				CAGCACTCGTGAGGTGTACTG	0.358000													11	9					0	0	1	0	0
PDE5A	8654	broad.mit.edu	37	4	120446713	120446713	+	Missense_Mutation	SNP	C	C	T			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr4:120446713C>T	ENST00000354960.3	-	12	2089	c.1770G>A	c.(1768-1770)atG>atA	p.M590I	PDE5A_ENST00000512739.1_5'UTR|PDE5A_ENST00000264805.5_Missense_Mutation_p.M548I|PDE5A_ENST00000394439.1_Missense_Mutation_p.M538I|RP11-33B1.1_ENST00000498873.1_RNA	NM_001083.3	NP_001074.2	O76074	PDE5A_HUMAN	phosphodiesterase 5A, cGMP-specific	590	Catalytic (By similarity).				platelet activation|signal transduction	cytosol	3',5'-cyclic-GMP phosphodiesterase activity|cGMP binding|zinc ion binding			breast(4)|endometrium(2)|kidney(3)|large_intestine(8)|lung(7)|prostate(1)|skin(1)|urinary_tract(1)	27					Dipyridamole(DB00975)|Pentoxifylline(DB00806)|Sildenafil(DB00203)|Tadalafil(DB00820)|Theophylline(DB00277)|Vardenafil(DB00862)	CCTCATGTTTCATCTGGAAGT	0.403000													11	23					0	0	1	0	0
ROBO2	6092	broad.mit.edu	37	3	77651534	77651534	+	Missense_Mutation	SNP	G	G	A			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr3:77651534G>A	ENST00000461745.1	+	20	3928	c.3028G>A	c.(3028-3030)Gaa>Aaa	p.E1010K	ROBO2_ENST00000332191.8_Missense_Mutation_p.E1010K|ROBO2_ENST00000487694.3_Missense_Mutation_p.E1026K	NM_002942.4	NP_002933.1	Q9HCK4	ROBO2_HUMAN	roundabout, axon guidance receptor, homolog 2 (Drosophila)	1010					apoptosis involved in luteolysis|axon midline choice point recognition|cellular response to hormone stimulus|homophilic cell adhesion|metanephros development|negative regulation of negative chemotaxis|negative regulation of synaptogenesis|olfactory bulb interneuron development|positive regulation of axonogenesis|retinal ganglion cell axon guidance|ureteric bud development	axolemma|cell surface|integral to membrane	axon guidance receptor activity|identical protein binding	p.E1026*(1)|p.E1010*(1)		NS(1)|biliary_tract(5)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(23)|liver(1)|lung(52)|ovary(2)|pancreas(2)|prostate(5)|skin(8)|upper_aerodigestive_tract(1)	117				Epithelial(33;0.00199)|LUSC - Lung squamous cell carcinoma(21;0.008)|BRCA - Breast invasive adenocarcinoma(55;0.00884)|Lung(72;0.0183)|KIRC - Kidney renal clear cell carcinoma(39;0.0832)|Kidney(39;0.103)		CAGCATACATGAATTGGCTGT	0.428000													24	38					0	0	1	0	0
SEC24C	9632	broad.mit.edu	37	10	75527763	75527763	+	Nonsense_Mutation	SNP	C	C	T			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr10:75527763C>T	ENST00000339365.2	+	16	2341	c.2179C>T	c.(2179-2181)Cag>Tag	p.Q727*	SEC24C_ENST00000345254.4_Nonsense_Mutation_p.Q727*|SEC24C_ENST00000411652.2_Nonsense_Mutation_p.Q608*|SEC24C_ENST00000535742.1_Intron|SEC24C_ENST00000540668.1_Intron|SEC24C_ENST00000496827.1_Intron	NM_004922.3	NP_004913.2	P53992	SC24C_HUMAN	SEC24 family member C	727					COPII vesicle coating|intracellular protein transport|post-translational protein modification|protein N-linked glycosylation via asparagine	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|Golgi membrane|perinuclear region of cytoplasm	protein binding|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(3)|lung(12)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	32	Prostate(51;0.0112)					TGCTTCCTTTCAGGTATGGTG	0.493000													6	19					0	0	1	0	0
SEC24C	9632	broad.mit.edu	37	10	75527625	75527625	+	Nonsense_Mutation	SNP	C	C	T			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr10:75527625C>T	ENST00000339365.2	+	16	2203	c.2041C>T	c.(2041-2043)Cag>Tag	p.Q681*	SEC24C_ENST00000345254.4_Nonsense_Mutation_p.Q681*|SEC24C_ENST00000411652.2_Nonsense_Mutation_p.Q562*|SEC24C_ENST00000535742.1_Intron|SEC24C_ENST00000540668.1_Intron	NM_004922.3	NP_004913.2	P53992	SC24C_HUMAN	SEC24 family member C	681					COPII vesicle coating|intracellular protein transport|post-translational protein modification|protein N-linked glycosylation via asparagine	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|Golgi membrane|perinuclear region of cytoplasm	protein binding|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(3)|lung(12)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	32	Prostate(51;0.0112)					AGGTGCCTATCAGACCCTGGC	0.493000													25	61					0	0	1	0	0
KCNK10	54207	broad.mit.edu	37	14	88652241	88652241	+	Missense_Mutation	SNP	G	G	A			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr14:88652241G>A	ENST00000340700.5	-	7	1706	c.1255C>T	c.(1255-1257)Cgg>Tgg	p.R419W	KCNK10_ENST00000319231.5_Missense_Mutation_p.R424W|KCNK10_ENST00000312350.5_Missense_Mutation_p.R424W	NM_021161.4	NP_066984.1	P57789	KCNKA_HUMAN	potassium channel, subfamily K, member 10	419					signal transduction	integral to membrane	potassium channel activity|voltage-gated ion channel activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(25)|ovary(3)|pancreas(2)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)	47						TTGTTGGGCCGGTTGTTGATG	0.622000													28	12					0	0	1	0	0
FBLN1	2192	broad.mit.edu	37	22	45958819	45958819	+	Missense_Mutation	SNP	G	G	C			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr22:45958819G>C	ENST00000402984.3	+	16	1942	c.1839G>C	c.(1837-1839)gaG>gaC	p.E613D	FBLN1_ENST00000348697.2_Intron|FBLN1_ENST00000327858.6_Intron|FBLN1_ENST00000442170.2_Intron|FBLN1_ENST00000262722.7_Missense_Mutation_p.E575D			P23142	FBLN1_HUMAN	fibulin 1	584					interspecies interaction between organisms	extracellular space|soluble fraction	calcium ion binding|extracellular matrix structural constituent|protein binding			biliary_tract(1)|central_nervous_system(1)|endometrium(4)|kidney(5)|large_intestine(7)|lung(8)|ovary(2)|prostate(1)|skin(1)	30		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0182)		CTTGCCATGAGAATCGGGAGT	0.592000													108	198					0	0	1	0	0
CLVS2	134829	broad.mit.edu	37	6	123384818	123384818	+	Splice_Site	SNP	G	G	A			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr6:123384818G>A	ENST00000275162.5	+	6	2231		c.e6-1		CLVS2_ENST00000368438.1_Splice_Site	NM_001010852.3	NP_001010852.2	Q5SYC1	CLVS2_HUMAN	clavesin 2						lysosome organization	clathrin-coated vesicle|early endosome membrane|trans-Golgi network	phosphatidylinositol-3,5-bisphosphate binding|transporter activity			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(24)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(2)	40						ATCCTTTCCAGATCTCAATCA	0.388000													9	42					0	0	1	0	0
DPH2	1802	broad.mit.edu	37	1	44437073	44437073	+	Missense_Mutation	SNP	C	C	G			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr1:44437073C>G	ENST00000255108.3	+	4	671	c.499C>G	c.(499-501)Ctc>Gtc	p.L167V	DPH2_ENST00000529729.1_3'UTR|DPH2_ENST00000412950.2_Missense_Mutation_p.L32V|DPH2_ENST00000396758.2_Intron	NM_001384.4	NP_001375.2	Q9BQC3	DPH2_HUMAN	DPH2 homolog (S. cerevisiae)	167					peptidyl-diphthamide biosynthetic process from peptidyl-histidine	cytoplasm				autonomic_ganglia(1)|kidney(2)|large_intestine(2)|lung(10)|ovary(1)|prostate(2)|skin(1)	19	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0511)				TTTGGCTACTCTCCTGCGCCC	0.572000													77	58					0	0	1	0	0
ATP2B2	491	broad.mit.edu	37	3	10387112	10387112	+	Missense_Mutation	SNP	C	C	T			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr3:10387112C>T	ENST00000397077.1	-	17	3099	c.2524G>A	c.(2524-2526)Gtg>Atg	p.V842M	ATP2B2_ENST00000383800.4_Missense_Mutation_p.V842M|ATP2B2_ENST00000352432.4_Missense_Mutation_p.V887M|ATP2B2_ENST00000360273.2_Missense_Mutation_p.V887M|ATP2B2_ENST00000343816.4_Missense_Mutation_p.V873M			Q01814	AT2B2_HUMAN	ATPase, Ca++ transporting, plasma membrane 2	887					ATP biosynthetic process|cytosolic calcium ion homeostasis|platelet activation	cytosol|integral to membrane|plasma membrane	ATP binding|calcium ion binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding|PDZ domain binding|protein C-terminus binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(7)|large_intestine(19)|lung(29)|ovary(5)|prostate(2)|skin(4)|stomach(2)|urinary_tract(2)	74						ACGGCCACCACGTTGACGGTG	0.597000													37	50					0	0	1	0	0
TP53	7157	broad.mit.edu	37	17	7574021	7574021	+	Nonsense_Mutation	SNP	C	C	A			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr17:7574021C>A	ENST00000269305.4	-	10	1195	c.1006G>T	c.(1006-1008)Gag>Tag	p.E336*	TP53_ENST00000413465.2_Intron|TP53_ENST00000445888.2_Nonsense_Mutation_p.E336*|TP53_ENST00000420246.2_3'UTR|TP53_ENST00000359597.4_Intron|TP53_ENST00000455263.2_3'UTR	NM_000546.5|NM_001126112.2|NM_001126118.1|NM_001276760.1|NM_001276761.1	NP_000537.3|NP_001119584.1|NP_001119590.1|NP_001263689.1|NP_001263690.1	P04637	P53_HUMAN	tumor protein p53	336	Interaction with CARM1.|Interaction with HIPK1 (By similarity).|Interaction with HIPK2.|Oligomerization.				activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.0?(8)|p.E336*(5)|p.I332fs*5(1)|p.E336fs*12(1)|p.?(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		TCGAAGCGCTCACGCCCACGG	0.517000		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			13	4					9.31168e-06	9.50133e-06	1	1	0
OTOP3	347741	broad.mit.edu	37	17	72945415	72945415	+	Missense_Mutation	SNP	G	G	C			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr17:72945415G>C	ENST00000328801.4	+	7	1695	c.1695G>C	c.(1693-1695)caG>caC	p.Q565H		NM_178233.1	NP_839947.1	Q7RTS5	OTOP3_HUMAN	otopetrin 3	565						integral to membrane|intracellular	zinc ion binding			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(5)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	23	all_lung(278;0.151)|Lung NSC(278;0.185)					ACGGCTACCAGATATGGTTCG	0.567000													14	96					0	0	1	0	0
TICAM1	148022	broad.mit.edu	37	19	4817081	4817081	+	Missense_Mutation	SNP	C	C	T			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr19:4817081C>T	ENST00000248244.5	-	2	1538	c.1309G>A	c.(1309-1311)Ggg>Agg	p.G437R		NM_182919.3	NP_891549.1	Q8IUC6	TCAM1_HUMAN	toll-like receptor adaptor molecule 1	437	TIR.				apoptosis|I-kappaB kinase/NF-kappaB cascade|inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|endosome membrane|plasma membrane	protein kinase binding|signal transducer activity			NS(2)|breast(2)|endometrium(2)|kidney(2)|large_intestine(4)|lung(6)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	26				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0139)		CTCAGCTCCCCGCGCCCCGGC	0.637000													39	26					0	0	1	0	0
CSNK2B	1460	broad.mit.edu	37	6	31636389	31636389	+	Missense_Mutation	SNP	C	C	G			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr6:31636389C>G	ENST00000375880.2	+	4	367	c.249C>G	c.(247-249)atC>atG	p.I83M	CSNK2B_ENST00000375885.4_Missense_Mutation_p.I102M|CSNK2B_ENST00000375866.2_Missense_Mutation_p.I83M|CSNK2B_ENST00000375882.2_Missense_Mutation_p.I83M|CSNK2B_ENST00000375865.2_Missense_Mutation_p.I83M																							ATGGATTGATCCACGCCCGCT	0.547000													105	68					0	0	1	0	0
OR8H2	390151	broad.mit.edu	37	11	55872896	55872896	+	Silent	SNP	C	C	T			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr11:55872896C>T	ENST00000313503.1	+	1	378	c.378C>T	c.(376-378)atC>atT	p.I126I		NM_001005200.1	NP_001005200.1	Q8N162	OR8H2_HUMAN	olfactory receptor, family 8, subfamily H, member 2	126					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(38)|ovary(1)|skin(3)|stomach(2)|upper_aerodigestive_tract(5)|urinary_tract(1)	61	Esophageal squamous(21;0.00693)					ATGCAGCGATCTGCAGTCCTC	0.478000										HNSCC(53;0.14)			6	251					0	0	1	0	0
APOB	338	broad.mit.edu	37	2	21228694	21228694	+	Missense_Mutation	SNP	C	C	G			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr2:21228694C>G	ENST00000233242.1	-	26	11173	c.11046G>C	c.(11044-11046)aaG>aaC	p.K3682N		NM_000384.2	NP_000375	P04114	APOB_HUMAN	apolipoprotein B	3682					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			NS(5)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(19)|kidney(10)|large_intestine(63)|liver(5)|lung(125)|ovary(16)|pancreas(1)|prostate(5)|skin(31)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(6)	305	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	CCCATAAGCTCTTGTCATAGA	0.438000													8	50					0	0	1	0	0
TNR	7143	broad.mit.edu	37	1	175299342	175299342	+	Nonsense_Mutation	SNP	G	G	A			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr1:175299342G>A	ENST00000367674.2	-	21	4369	c.3661C>T	c.(3661-3663)Cag>Tag	p.Q1221*	RP3-518E13.2_ENST00000569593.1_RNA|TNR_ENST00000263525.2_Nonsense_Mutation_p.Q1221*			Q92752	TENR_HUMAN	tenascin R		Fibrinogen C-terminal.				axon guidance|cell adhesion|signal transduction	proteinaceous extracellular matrix		p.Q1221*(1)		NS(3)|breast(7)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(29)|lung(98)|ovary(4)|pancreas(5)|prostate(4)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	177	Renal(580;0.146)					TAGCGGCCCTGGGATGTGATC	0.567000													12	43					0	0	1	0	0
KRTAP13-1	140258	broad.mit.edu	37	21	31768886	31768886	+	Missense_Mutation	SNP	G	G	A			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr21:31768886G>A	ENST00000355459.2	+	1	495	c.482G>A	c.(481-483)tGc>tAc	p.C161Y		NM_181599.2	NP_853630.2	Q8IUC0	KR131_HUMAN	keratin associated protein 13-1	161						intermediate filament				endometrium(1)|kidney(2)|large_intestine(3)|lung(12)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	22						CAGTCTTCTTGCTACAGACCA	0.478000													6	34					0	0	1	0	0
DNAH17	8632	broad.mit.edu	37	17	76525721	76525721	+	Missense_Mutation	SNP	G	G	A			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr17:76525721G>A	ENST00000389840.5	-	22	3464	c.3340C>T	c.(3340-3342)Ctc>Ttc	p.L1114F	DNAH17_ENST00000585328.1_Missense_Mutation_p.L1111F					dynein, axonemal, heavy chain 17											NS(2)|breast(7)|central_nervous_system(5)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(13)|large_intestine(8)|lung(37)|ovary(8)|prostate(7)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	116			BRCA - Breast invasive adenocarcinoma(99;0.00294)|OV - Ovarian serous cystadenocarcinoma(97;0.0656)			CCCTCCTTGAGGGGCTTGGTC	0.577000													18	80					0	0	1	0	0
ATP6V1C2	245973	broad.mit.edu	37	2	10912040	10912040	+	Silent	SNP	C	C	T			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr2:10912040C>T	ENST00000381661.3	+	7	655	c.546C>T	c.(544-546)gtC>gtT	p.V182V	ATP6V1C2_ENST00000272238.4_Silent_p.V182V	NM_144583.3	NP_653184.2	Q8NEY4	VATC2_HUMAN	ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C2	182					ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|insulin receptor signaling pathway|transferrin transport	cytosol|proton-transporting V-type ATPase, V1 domain				endometrium(2)|kidney(1)|large_intestine(3)|lung(8)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	19	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.191)			Epithelial(75;0.15)|OV - Ovarian serous cystadenocarcinoma(76;0.152)		AATATCTCGTCACACTTCTGG	0.552000													59	87					0	0	1	0	0
CCT8L2	150160	broad.mit.edu	37	22	17072544	17072544	+	Silent	SNP	G	G	A	rs141440063		TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr22:17072544G>A	ENST00000359963.3	-	1	1156	c.897C>T	c.(895-897)gtC>gtT	p.V299V		NM_014406.4	NP_055221.1	Q96SF2	TCPQM_HUMAN	chaperonin containing TCP1, subunit 8 (theta)-like 2	299					cellular protein metabolic process	cytoplasm	anion channel activity|ATP binding|calcium-activated potassium channel activity			breast(3)|endometrium(7)|kidney(1)|large_intestine(8)|liver(2)|lung(37)|ovary(3)|prostate(3)|skin(2)|stomach(1)	67	all_hematologic(4;0.00567)|Acute lymphoblastic leukemia(84;0.0977)	all_epithelial(15;0.0157)|Lung NSC(13;0.147)|all_lung(157;0.175)				TCTCCTCGTCGACCTCCCCCA	0.488000													52	114					0	0	1	0	0
GYG2	8908	broad.mit.edu	37	X	2779646	2779646	+	Silent	SNP	G	G	A			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chrX:2779646G>A	ENST00000381163.3	+	9	1296	c.1014G>A	c.(1012-1014)gcG>gcA	p.A338A	GYG2_ENST00000398806.3_Silent_p.A307A|GYG2_ENST00000542787.1_Silent_p.A338A|GYG2_ENST00000338623.5_Silent_p.A338A|GYG2_ENST00000381161.1_3'UTR	NM_001079855.1|NM_001184702.1|NM_003918.2	NP_001073324.1|NP_001171631.1|NP_003909.2	O15488	GLYG2_HUMAN	glycogenin 2	338					glucose metabolic process|glycogen biosynthetic process|glycogen catabolic process	cytosol|soluble fraction	glycogenin glucosyltransferase activity			endometrium(1)|kidney(1)|large_intestine(5)|lung(5)|ovary(1)	13		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				CACCCAGTGCGGGCGTGCCGT	0.577000													13	3					0	0	1	0	0
SYNE3	161176	broad.mit.edu	37	14	95905975	95905975	+	Silent	SNP	C	C	T			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr14:95905975C>T	ENST00000334258.5	-	12	2234	c.2220G>A	c.(2218-2220)ttG>ttA	p.L740L	SYNE3_ENST00000557275.1_Silent_p.L740L|SYNE3_ENST00000554873.1_Silent_p.L497L	NM_152592.3	NP_689805.3			spectrin repeat containing, nuclear envelope family member 3											breast(1)|endometrium(2)|lung(25)	28						CCAGCAGCCTCAAGGCCCGCC	0.627000													38	12					0	0	1	0	0
CSRNP3	80034	broad.mit.edu	37	2	166535763	166535763	+	Missense_Mutation	SNP	G	G	A	rs142235040	by1000genomes	TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr2:166535763G>A	ENST00000314499.7	+	7	1634	c.1258G>A	c.(1258-1260)Gaa>Aaa	p.E420K	CSRNP3_ENST00000342316.4_Missense_Mutation_p.E420K|CSRNP3_ENST00000409420.1_Missense_Mutation_p.E452K	NM_001172173.1	NP_001165644.1	Q8WYN3	CSRN3_HUMAN	cysteine-serine-rich nuclear protein 3	420					apoptosis|positive regulation of apoptosis|positive regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|cervix(1)|endometrium(1)|large_intestine(9)|lung(15)|ovary(3)|skin(2)	33						CGCCGTTCACGAAAGCCATGC	0.448000													21	66					0	0	1	0	0
GATA3	2625	broad.mit.edu	37	10	8106047	8106047	+	Silent	SNP	C	C	T	rs575091		TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr10:8106047C>T	ENST00000379328.3	+	4	1438	c.870C>T	c.(868-870)ctC>ctT	p.L290L	GATA3_ENST00000461472.1_Intron|GATA3_ENST00000346208.3_Silent_p.L289L	NM_001002295.1|NM_002051.2	NP_001002295.1|NP_002042.1	P23771	GATA3_HUMAN	GATA binding protein 3	289					aortic valve morphogenesis|blood coagulation|canonical Wnt receptor signaling pathway involved in metanephric kidney development|cardiac right ventricle morphogenesis|cell fate determination|cellular response to interferon-alpha|cellular response to interleukin-4|cellular response to tumor necrosis factor|defense response|ear development|lymphocyte migration|male gonad development|mesenchymal to epithelial transition|mesonephros development|negative regulation of cell cycle|negative regulation of cell motility|negative regulation of cell proliferation involved in mesonephros development|negative regulation of endothelial cell apoptosis|negative regulation of fat cell differentiation|negative regulation of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation|negative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation|negative regulation of inflammatory response|negative regulation of mammary gland epithelial cell proliferation|nephric duct formation|norepinephrine biosynthetic process|pharyngeal system development|phosphatidylinositol 3-kinase cascade|positive regulation of endothelial cell migration|positive regulation of interleukin-13 secretion|positive regulation of interleukin-4 production|positive regulation of interleukin-5 secretion|positive regulation of protein kinase B signaling cascade|positive regulation of T cell differentiation|positive regulation of thyroid hormone generation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription regulatory region DNA binding|positive regulation of ureteric bud formation|regulation of cellular response to X-ray|regulation of cytokine biosynthetic process|regulation of nephron tubule epithelial cell differentiation|response to estrogen stimulus|response to virus|sympathetic nervous system development|T cell receptor signaling pathway|TOR signaling cascade|ureteric bud formation|uterus development|ventricular septum development	nuclear chromatin|nucleolus|nucleoplasm	core promoter proximal region sequence-specific DNA binding|core promoter sequence-specific DNA binding|E-box binding|HMG box domain binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|transcription coactivator activity|transcription factor binding|zinc ion binding			NS(1)|breast(44)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(6)|lung(24)|ovary(3)|skin(2)	87						CCTGCGGGCTCTATCACAAAA	0.572000			"""F, N, S"""		breast		"""HDR syndrome (HYPOPARATHYROIDISM, SENSORINEURAL DEAFNESS, AND RENAL DISEASE)"""						19	63					0	0	1	0	0
ADGRG1	9289	broad.mit.edu	37	16	57685530	57685530	+	Silent	SNP	C	C	T			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr16:57685530C>T	ENST00000562631.1	+	3	1015	c.483C>T	c.(481-483)ttC>ttT	p.F161F	GPR56_ENST00000379696.3_Silent_p.F161F|GPR56_ENST00000540164.2_Silent_p.F161F|GPR56_ENST00000388812.4_Silent_p.F161F|GPR56_ENST00000568908.1_Silent_p.F161F|GPR56_ENST00000538815.1_Silent_p.F161F|GPR56_ENST00000544297.1_5'UTR|GPR56_ENST00000567835.1_Silent_p.F161F|GPR56_ENST00000562558.1_Silent_p.F161F|GPR56_ENST00000568909.1_Silent_p.F161F|GPR56_ENST00000564912.1_3'UTR|GPR56_ENST00000379694.4_Intron|GPR56_ENST00000456916.1_Silent_p.F161F|GPR56_ENST00000388813.5_Silent_p.F161F			Q9Y653	GPR56_HUMAN	G protein-coupled receptor 56	161					brain development|cell adhesion|cell-cell signaling|neuropeptide signaling pathway	integral to plasma membrane	G-protein coupled receptor activity			kidney(1)|large_intestine(3)|lung(9)|prostate(1)|skin(1)	15						CCTTCTCCTTCCACAGTAAGG	0.582000													20	25					0	0	1	0	0
RNF111	54778	broad.mit.edu	37	15	59348035	59348035	+	Missense_Mutation	SNP	G	G	A			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr15:59348035G>A	ENST00000348370.4	+	4	1595	c.1162G>A	c.(1162-1164)Gat>Aat	p.D388N	RNF111_ENST00000557998.1_Missense_Mutation_p.D388N|RNF111_ENST00000561186.1_Missense_Mutation_p.D388N|RNF111_ENST00000434298.1_Missense_Mutation_p.D388N|RNF111_ENST00000559209.1_Missense_Mutation_p.D388N	NM_001270528.1|NM_001270529.1|NM_017610.7	NP_001257457.1|NP_001257458.1|NP_060080.6	Q6ZNA4	RN111_HUMAN	ring finger protein 111	388	Interaction with AXIN1.|Ser-rich.				multicellular organismal development|positive regulation of transcription, DNA-dependent	cytoplasm|nucleus	protein binding|ubiquitin-protein ligase activity|zinc ion binding			breast(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(9)|lung(11)|ovary(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	35				all cancers(107;0.194)		CCTTACCGTTGATGAAGATGG	0.423000													8	27					0	0	1	0	0
C1orf51	148523	broad.mit.edu	37	1	150256286	150256286	+	Missense_Mutation	SNP	G	G	C			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr1:150256286G>C	ENST00000290363.5	+	2	887	c.438G>C	c.(436-438)gaG>gaC	p.E146D	C1orf51_ENST00000369094.1_Missense_Mutation_p.E58D|C1orf51_ENST00000469255.1_Intron|C1orf51_ENST00000369095.1_Missense_Mutation_p.E146D	NM_144697.2	NP_653298.1	Q8N365	CA051_HUMAN	chromosome 1 open reading frame 51	146										endometrium(3)|large_intestine(2)|lung(3)|urinary_tract(2)	10	Lung NSC(24;7.29e-29)|Breast(34;0.00211)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.161)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.171)			GTCGTTTTGAGAGAGGTAATC	0.413000													28	81					0	0	1	0	0
LETM1	3954	broad.mit.edu	37	4	1827401	1827401	+	Missense_Mutation	SNP	C	C	T			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr4:1827401C>T	ENST00000302787.2	-	7	1386	c.1090G>A	c.(1090-1092)Gag>Aag	p.E364K		NM_012318.2	NP_036450.1	O95202	LETM1_HUMAN	leucine zipper-EF-hand containing transmembrane protein 1	364	LETM1.				cristae formation	integral to membrane|mitochondrial inner membrane	calcium ion binding|protein binding			breast(3)|central_nervous_system(2)|large_intestine(3)|lung(3)|prostate(1)|urinary_tract(1)	13			all cancers(2;0.00756)|OV - Ovarian serous cystadenocarcinoma(23;0.00989)|Epithelial(3;0.0141)			ACCCCTTCCTCAGCAATCAGC	0.567000													6	35					0	0	1	0	0
AZIN1	51582	broad.mit.edu	37	8	103845432	103845432	+	Missense_Mutation	SNP	G	G	C			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr8:103845432G>C	ENST00000337198.5	-	9	1919	c.756C>G	c.(754-756)atC>atG	p.I252M	AZIN1_ENST00000347770.4_Missense_Mutation_p.I252M	NM_148174.2	NP_680479.1	O14977	AZIN1_HUMAN	antizyme inhibitor 1	252					polyamine biosynthetic process|regulation of cellular amino acid metabolic process	cytosol	catalytic activity|protein binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(1)|prostate(1)|skin(1)|stomach(1)	9	Lung NSC(17;0.000143)|all_lung(17;0.000294)		OV - Ovarian serous cystadenocarcinoma(57;0.000196)|STAD - Stomach adenocarcinoma(118;0.0414)			ACAGAGGGCTGATAACATGAT	0.343000													11	263					0	0	1	0	0
MED13	9969	broad.mit.edu	37	17	60038310	60038310	+	Missense_Mutation	SNP	G	G	C			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr17:60038310G>C	ENST00000397786.2	-	23	5474	c.5398C>G	c.(5398-5400)Caa>Gaa	p.Q1800E		NM_005121.2	NP_005112.2	Q9UHV7	MED13_HUMAN	mediator complex subunit 13	1800					androgen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			breast(4)|central_nervous_system(1)|endometrium(10)|kidney(24)|large_intestine(15)|liver(1)|lung(20)|ovary(1)|prostate(3)|skin(2)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	88						ATCCACCTTTGATCATGTGAT	0.368000													14	49					0	0	1	0	0
TSGA10IP	254187	broad.mit.edu	37	11	65714412	65714412	+	RNA	SNP	C	C	T			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr11:65714412C>T	ENST00000608857.1	+	0	209				TSGA10IP_ENST00000532620.1_RNA	NM_152762.2	NP_689975.2	Q3SY00	T10IP_HUMAN	testis specific, 10 interacting protein											endometrium(2)|kidney(3)|lung(9)	14						TCTCAGAGCTCAAGGCAGACA	0.592000													35	31					0	0	1	0	0
GREB1	9687	broad.mit.edu	37	2	11725904	11725904	+	Silent	SNP	C	C	T			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr2:11725904C>T	ENST00000381486.2	+	9	1332	c.1032C>T	c.(1030-1032)tcC>tcT	p.S344S	GREB1_ENST00000263834.5_Silent_p.S344S|GREB1_ENST00000381483.2_Silent_p.S344S|GREB1_ENST00000234142.5_Silent_p.S344S	NM_014668.3	NP_055483.2	Q4ZG55	GREB1_HUMAN	growth regulation by estrogen in breast cancer 1	344						integral to membrane				breast(3)|central_nervous_system(2)|endometrium(2)|kidney(4)|large_intestine(9)|lung(9)|ovary(1)	30	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.115)|OV - Ovarian serous cystadenocarcinoma(76;0.186)		CAGGCATGTCCTGCGTGCCGC	0.517000													27	36					0	0	1	0	0
C16orf87	388272	broad.mit.edu	37	16	46836885	46836885	+	Silent	SNP	G	G	A			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr16:46836885G>A	ENST00000394806.2	-	3	273	c.261C>T	c.(259-261)atC>atT	p.I87I	C16orf87_ENST00000285697.4_Silent_p.I148I			Q6PH81	CP087_HUMAN	chromosome 16 open reading frame 87	148										large_intestine(4)|urinary_tract(1)	5						GTCTTTGATTGATAATTTTTC	0.368000													11	18					0	0	1	0	0
KIAA1407	57577	broad.mit.edu	37	3	113684115	113684115	+	Missense_Mutation	SNP	G	G	A			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr3:113684115G>A	ENST00000295878.3	-	17	2844	c.2698C>T	c.(2698-2700)Cgt>Tgt	p.R900C		NM_020817.1	NP_065868.1	Q8NCU4	K1407_HUMAN	KIAA1407	900										endometrium(9)|large_intestine(7)|lung(19)|ovary(2)|pancreas(1)|prostate(1)|urinary_tract(1)	40						ACCTTCCTACGAAGTTGCTGT	0.418000													5	101					0	0	1	0	0
HBZ	3050	broad.mit.edu	37	16	202996	202996	+	Silent	SNP	C	C	T			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr16:202996C>T	ENST00000252951.2	+	1	311	c.88C>T	c.(88-90)Ctg>Ttg	p.L30L		NM_005332.2	NP_005323.1	P02008	HBAZ_HUMAN	hemoglobin, zeta	30						hemoglobin complex	heme binding|oxygen binding|oxygen transporter activity						all_cancers(16;4.28e-07)|all_epithelial(16;2.09e-06)|Hepatocellular(16;0.000325)|Lung NSC(18;0.0104)|all_lung(18;0.0239)				CACCGAGACTCTGGAGAGGTG	0.637000													4	33					0	0	1	0	0
EPDR1	54749	broad.mit.edu	37	7	37960801	37960801	+	Missense_Mutation	SNP	C	C	T			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr7:37960801C>T	ENST00000199448.4	+	1	639	c.260C>T	c.(259-261)cCc>cTc	p.P87L	EPDR1_ENST00000423717.1_Missense_Mutation_p.P87L|EPDR1_ENST00000559325.1_Missense_Mutation_p.P207L|EPDR1_ENST00000476620.1_Intron	NM_017549.4	NP_060019.2	Q9UM22	EPDR1_HUMAN	ependymin related 1	87					cell-matrix adhesion	extracellular region	calcium ion binding			breast(1)|endometrium(1)|large_intestine(2)|lung(9)|ovary(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	22						GCGCTGATCCCCTGCAAGAGG	0.682000													14	11					0	0	1	0	0
CMTM4	146223	broad.mit.edu	37	16	66670431	66670431	+	Silent	SNP	C	C	T	rs146201516		TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr16:66670431C>T	ENST00000330687.4	-	2	421	c.240G>A	c.(238-240)ccG>ccA	p.P80P	CMTM4_ENST00000563952.1_Silent_p.P51P|CMTM4_ENST00000394106.2_Silent_p.P80P	NM_178818.2|NM_181521.2	NP_848933.1|NP_852662.1	Q8IZR5	CKLF4_HUMAN	CKLF-like MARVEL transmembrane domain containing 4	80	MARVEL.				chemotaxis	extracellular space|integral to membrane	cytokine activity			cervix(1)|kidney(1)|large_intestine(3)|lung(1)|ovary(1)|pancreas(1)|stomach(1)	9		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0811)|Epithelial(162;0.214)		GGCCTTCACACGGGGAGCATG	0.443000													35	59					0	0	1	0	0
TECRL	253017	broad.mit.edu	37	4	65275064	65275064	+	Missense_Mutation	SNP	G	G	C			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr4:65275064G>C	ENST00000381210.3	-	1	116	c.6C>G	c.(4-6)ttC>ttG	p.F2L	TECRL_ENST00000507440.1_Missense_Mutation_p.F2L	NM_001010874.4	NP_001010874.2	Q5HYJ1	TECRL_HUMAN	trans-2,3-enoyl-CoA reductase-like	2					lipid metabolic process	cytoplasm|integral to membrane	oxidoreductase activity, acting on the CH-CH group of donors			endometrium(2)|kidney(5)|large_intestine(7)|lung(30)|prostate(1)|skin(1)|stomach(1)	47						TGTGCCTTTTGAACATTGTGT	0.403000													14	38					0	0	1	0	0
HAND1	9421	broad.mit.edu	37	5	153857102	153857102	+	Missense_Mutation	SNP	G	G	A			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr5:153857102G>A	ENST00000231121.2	-	1	722	c.467C>T	c.(466-468)tCt>tTt	p.S156F		NM_004821.2	NP_004812.1	O96004	HAND1_HUMAN	heart and neural crest derivatives expressed 1	156					angiogenesis|cardiac left ventricle formation|cardiac right ventricle formation|cardiac septum morphogenesis|heart looping|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|trophectodermal cell differentiation|ventricular cardiac muscle tissue morphogenesis	cytoplasm|nucleolus|nucleoplasm	bHLH transcription factor binding|DNA binding|protein homodimerization activity|transcription coactivator activity			endometrium(1)|kidney(1)|large_intestine(2)|lung(2)	6	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.147)	Kidney(363;8.21e-05)|KIRC - Kidney renal clear cell carcinoma(527;0.000577)			GGGATCGCCAGACTGTGCATC	0.607000													62	48					0	0	1	0	0
GDPD1	284161	broad.mit.edu	37	17	57326144	57326144	+	Missense_Mutation	SNP	G	G	C			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr17:57326144G>C	ENST00000284116.4	+	4	502	c.365G>C	c.(364-366)aGa>aCa	p.R122T	GDPD1_ENST00000581276.1_Missense_Mutation_p.R122T|GDPD1_ENST00000581140.1_Missense_Mutation_p.R122T	NM_182569.3	NP_872375.2	Q8N9F7	GDPD1_HUMAN	glycerophosphodiester phosphodiesterase domain containing 1	122	GDPD.				glycerol metabolic process|lipid metabolic process	cytoplasm|integral to membrane	glycerophosphodiester phosphodiesterase activity|metal ion binding			endometrium(1)|kidney(1)|liver(1)|lung(2)|upper_aerodigestive_tract(1)	6	all_neural(34;0.0837)|Medulloblastoma(34;0.0922)					TCATTTCAAAGAGGTAATATT	0.303000													13	81					0	0	1	0	0
RNF122	79845	broad.mit.edu	37	8	33408568	33408568	+	Silent	SNP	T	T	C			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr8:33408568T>C	ENST00000256257.1	-	4	665	c.264A>G	c.(262-264)ttA>ttG	p.L88L		NM_024787.2	NP_079063.2	Q9H9V4	RN122_HUMAN	ring finger protein 122	88						endoplasmic reticulum|Golgi apparatus|integral to membrane	zinc ion binding			endometrium(2)|large_intestine(3)|ovary(1)|upper_aerodigestive_tract(1)	7				KIRC - Kidney renal clear cell carcinoma(67;0.0966)|Kidney(114;0.116)		TTACCCCATATAATTGTAACT	0.507000													75	347					0	0	1	0	0
CHRM3	1131	broad.mit.edu	37	1	240071577	240071577	+	Missense_Mutation	SNP	G	G	A			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr1:240071577G>A	ENST00000255380.4	+	5	1605	c.826G>A	c.(826-828)Gag>Aag	p.E276K		NM_000740.2	NP_000731.1	P20309	ACM3_HUMAN	cholinergic receptor, muscarinic 3	276					cell proliferation|energy reserve metabolic process|nervous system development|protein modification process|regulation of insulin secretion	basolateral plasma membrane|cell junction|integral to plasma membrane|postsynaptic membrane	muscarinic acetylcholine receptor activity|phosphatidylinositol phospholipase C activity			breast(3)|endometrium(5)|kidney(2)|large_intestine(4)|lung(19)|ovary(4)|prostate(1)|skin(12)|upper_aerodigestive_tract(1)	51	Ovarian(103;0.127)	all_cancers(173;0.00567)|all_neural(198;0.203)	OV - Ovarian serous cystadenocarcinoma(106;0.00989)		Anisotropine Methylbromide(DB00517)|Atropine(DB00572)|Benzquinamide(DB00767)|Cevimeline(DB00185)|Cryptenamine(DB00785)|Cyclizine(DB01176)|Darifenacin(DB00496)|Diphemanil Methylsulfate(DB00729)|Diphenidol(DB01231)|Homatropine Methylbromide(DB00725)|Methotrimeprazine(DB01403)|Metixene(DB00340)|Olanzapine(DB00334)|Oxybutynin(DB01062)|Oxyphencyclimine(DB00383)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Solifenacin(DB01591)|Thiethylperazine(DB00372)|Tiotropium(DB01409)|Tolterodine(DB01036)|Tridihexethyl(DB00505)	GACAGAGGCAGAGACAGAAAA	0.488000													14	44					0	0	1	0	0
KIAA1429	25962	broad.mit.edu	37	8	95500998	95500998	+	Nonsense_Mutation	SNP	G	G	C			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr8:95500998G>C	ENST00000297591.5	-	24	5450	c.5375C>G	c.(5374-5376)tCa>tGa	p.S1792*	KIAA1429_ENST00000437199.1_3'UTR	NM_015496.4	NP_056311.2	Q69YN4	VIR_HUMAN	KIAA1429	1792					mRNA processing|RNA splicing	nucleus				NS(1)|breast(3)|central_nervous_system(1)|endometrium(4)|kidney(5)|large_intestine(16)|lung(28)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	66	Breast(36;3.29e-05)		BRCA - Breast invasive adenocarcinoma(8;0.00185)			CTTTCCTCTTGAGCCTCCACT	0.493000													144	32					0	0	1	0	0
CENPE	1062	broad.mit.edu	37	4	104082605	104082605	+	Missense_Mutation	SNP	C	C	T			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr4:104082605C>T	ENST00000265148.3	-	19	1941	c.1852G>A	c.(1852-1854)Gaa>Aaa	p.E618K	CENPE_ENST00000380026.3_Missense_Mutation_p.E593K	NM_001813.2	NP_001804.2	Q02224	CENPE_HUMAN	centromere protein E, 312kDa	618					blood coagulation|cell division|kinetochore assembly|microtubule-based movement|mitotic chromosome movement towards spindle pole|mitotic metaphase|mitotic metaphase plate congression|mitotic prometaphase|multicellular organismal development|positive regulation of protein kinase activity	condensed chromosome kinetochore|cytosol|microtubule|nucleus|spindle	ATP binding|kinetochore binding|microtubule motor activity			NS(3)|breast(6)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(20)|lung(34)|ovary(5)|pancreas(1)|prostate(2)|skin(3)|stomach(5)|urinary_tract(3)	101				OV - Ovarian serous cystadenocarcinoma(123;2.95e-08)		TTTGGGTCTTCAATGCTTTCC	0.373000													23	30					0	0	1	0	0
RIC8A	60626	broad.mit.edu	37	11	208894	208894	+	Nonsense_Mutation	SNP	G	G	T			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr11:208894G>T	ENST00000526104.1	+	1	1384	c.40G>T	c.(40-42)Gag>Tag	p.E14*	RIC8A_ENST00000325207.5_Nonsense_Mutation_p.E14*			Q9NPQ8	RIC8A_HUMAN	RIC8 guanine nucleotide exchange factor A	14						cytoplasm|plasma membrane	guanyl-nucleotide exchange factor activity			endometrium(3)|kidney(1)|large_intestine(3)|lung(3)|pancreas(1)|prostate(1)|skin(1)	13		all_cancers(49;9.23e-07)|all_epithelial(84;0.000315)|Breast(177;0.00122)|Ovarian(85;0.0202)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;4.45e-27)|Epithelial(43;2.94e-26)|OV - Ovarian serous cystadenocarcinoma(40;5.86e-21)|BRCA - Breast invasive adenocarcinoma(625;3.57e-05)|Lung(200;0.105)|LUSC - Lung squamous cell carcinoma(625;0.122)		GGAGACGGGTGAGGAGGATGT	0.716000													6	0					1.6384e-10	1.73173e-10	1	1	0
GTF2H3	2967	broad.mit.edu	37	12	124130058	124130058	+	Missense_Mutation	SNP	C	C	A			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr12:124130058C>A	ENST00000543341.2	+	3	181	c.150C>A	c.(148-150)ttC>ttA	p.F50L	GTF2H3_ENST00000228955.7_Missense_Mutation_p.F9L	NM_001271867.1|NM_001516.3	NP_001258796.1|NP_001507.2	Q13889	TF2H3_HUMAN	general transcription factor IIH, polypeptide 3, 34kDa	50					mRNA capping|nucleotide-excision repair, DNA damage removal|positive regulation of viral transcription|protein phosphorylation|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase I promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	core TFIIH complex|holo TFIIH complex	damaged DNA binding|metal ion binding|protein N-terminus binding|sequence-specific DNA binding transcription factor activity|translation factor activity, nucleic acid binding			breast(2)|endometrium(1)|large_intestine(4)|lung(2)|urinary_tract(1)	10	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;7.1e-05)|Epithelial(86;0.000388)|all cancers(50;0.00362)		CGCATTTATTCATGAATCGTT	0.358000								Nucleotide excision repair (NER)					8	28					4.68919e-08	4.87403e-08	1	1	0
PNLDC1	154197	broad.mit.edu	37	6	160240103	160240103	+	Silent	SNP	C	C	G			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr6:160240103C>G	ENST00000610273.1	+	17	1521	c.1350C>G	c.(1348-1350)gtC>gtG	p.V450V	PNLDC1_ENST00000392167.3_Silent_p.V461V	NM_001271862.1|NM_173516.1	NP_001258791.1|NP_775787.1	Q8NA58	PNDC1_HUMAN	poly(A)-specific ribonuclease (PARN)-like domain containing 1							integral to membrane|nucleus	nucleic acid binding			autonomic_ganglia(1)|breast(1)|endometrium(1)|kidney(2)|large_intestine(11)|lung(9)|ovary(1)|prostate(2)|skin(1)|stomach(1)|urinary_tract(1)	31		Breast(66;0.00519)|Ovarian(120;0.123)		OV - Ovarian serous cystadenocarcinoma(65;1.55e-18)|BRCA - Breast invasive adenocarcinoma(81;5.87e-06)		AGTTTGATGTCAGGCGACTCA	0.527000													36	34					0	0	1	0	0
LRRC1	55227	broad.mit.edu	37	6	53785428	53785428	+	Missense_Mutation	SNP	C	C	G			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr6:53785428C>G	ENST00000370888.1	+	13	1562	c.1285C>G	c.(1285-1287)Ctg>Gtg	p.L429V	RP3-523E19.2_ENST00000474641.2_RNA	NM_018214.4	NP_060684.4	Q9BTT6	LRRC1_HUMAN	leucine rich repeat containing 1	429						cytoplasm|membrane				cervix(1)|endometrium(3)|large_intestine(5)|lung(6)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	20	Lung NSC(77;0.0147)			BRCA - Breast invasive adenocarcinoma(397;0.0745)		TGCAGAGAATCTGCCTCGCTG	0.473000													5	31					0	0	1	0	0
CDH22	64405	broad.mit.edu	37	20	44869807	44869807	+	Silent	SNP	C	C	G			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr20:44869807C>G	ENST00000372262.3	-	2	745	c.345G>C	c.(343-345)ctG>ctC	p.L115L	CDH22_ENST00000537909.1_Silent_p.L115L	NM_021248.1	NP_067071.1	Q9UJ99	CAD22_HUMAN	cadherin 22, type 2	115	Cadherin 1.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			endometrium(3)|kidney(1)|large_intestine(9)|lung(16)|ovary(4)|pancreas(1)|prostate(3)|skin(4)|urinary_tract(3)	44		Myeloproliferative disorder(115;0.0122)				TGTCGCCTGTCAGCTCGTCGA	0.627000													9	35					0	0	1	0	0
RBBP8	5932	broad.mit.edu	37	18	20573073	20573073	+	Missense_Mutation	SNP	C	C	T			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr18:20573073C>T	ENST00000399722.2	+	11	1634	c.1283C>T	c.(1282-1284)tCt>tTt	p.S428F	RBBP8_ENST00000360790.5_Missense_Mutation_p.S428F|RBBP8_ENST00000327155.5_Missense_Mutation_p.S428F|RBBP8_ENST00000399725.2_Missense_Mutation_p.S428F	NM_203291.1	NP_976036.1	Q99708	COM1_HUMAN	retinoblastoma binding protein 8	428					cell cycle checkpoint|DNA double-strand break processing involved in repair via single-strand annealing|meiosis|regulation of transcription from RNA polymerase II promoter	nucleus	damaged DNA binding|protein binding|single-stranded DNA specific endodeoxyribonuclease activity			central_nervous_system(1)|cervix(2)|endometrium(5)|large_intestine(2)|lung(9)|ovary(3)|prostate(1)|skin(1)	24	all_cancers(21;4.34e-05)|all_epithelial(16;8.3e-07)|Lung NSC(20;0.0107)|Colorectal(14;0.0202)|all_lung(20;0.0291)|Ovarian(20;0.19)		OV - Ovarian serous cystadenocarcinoma(1;0.00196)			GGTAAAGATTCTAACACTGAT	0.373000								Homologous recombination					21	18					0	0	1	0	0
RNF19A	25897	broad.mit.edu	37	8	101273804	101273804	+	Missense_Mutation	SNP	G	G	C			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr8:101273804G>C	ENST00000519449.1	-	9	1964	c.1648C>G	c.(1648-1650)Ctg>Gtg	p.L550V	RNF19A_ENST00000341084.2_Missense_Mutation_p.L550V|RNF19A_ENST00000523255.1_5'UTR	NM_001280539.1|NM_015435.3	NP_001267468.1|NP_056250.3	Q9NV58	RN19A_HUMAN	ring finger protein 19A, RBR E3 ubiquitin protein ligase	550					microtubule cytoskeleton organization|protein modification process	centrosome|integral to membrane	ligase activity|transcription factor binding|zinc ion binding			breast(3)|central_nervous_system(1)|endometrium(4)|large_intestine(5)|lung(11)|ovary(2)|pancreas(1)|prostate(2)|skin(1)	30	all_cancers(14;3.5e-05)|all_epithelial(15;8.91e-08)|Lung NSC(17;0.000615)|all_lung(17;0.00166)		Epithelial(11;3.06e-11)|all cancers(13;5.78e-09)|OV - Ovarian serous cystadenocarcinoma(57;2.24e-05)|STAD - Stomach adenocarcinoma(118;0.0525)			CTTCCTGACAGACTCCCCGTT	0.458000													37	231					0	0	1	0	0
KIAA0556	23247	broad.mit.edu	37	16	27763065	27763065	+	Missense_Mutation	SNP	C	C	G			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr16:27763065C>G	ENST00000261588.4	+	17	3391	c.3372C>G	c.(3370-3372)atC>atG	p.I1124M		NM_015202.2	NP_056017.2	O60303	K0556_HUMAN	KIAA0556	1124										breast(4)|endometrium(7)|kidney(8)|large_intestine(17)|lung(24)|ovary(5)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	76						GAGACACGATCTTATTCACAA	0.468000													37	64					0	0	1	0	0
SLC44A2	57153	broad.mit.edu	37	19	10753966	10753966	+	Nonsense_Mutation	SNP	G	G	T			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr19:10753966G>T	ENST00000335757.5	+	22	2402	c.2026G>T	c.(2026-2028)Gag>Tag	p.E676*	SLC44A2_ENST00000586078.1_3'UTR|SLC44A2_ENST00000407327.4_Nonsense_Mutation_p.E674*			Q8IWA5	CTL2_HUMAN	solute carrier family 44 (choline transporter), member 2	676					positive regulation of I-kappaB kinase/NF-kappaB cascade	integral to membrane|plasma membrane	choline transmembrane transporter activity|signal transducer activity			NS(1)|breast(3)|endometrium(5)|kidney(1)|large_intestine(7)|lung(4)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	27			Epithelial(33;8.7e-06)|all cancers(31;2.77e-05)		Choline(DB00122)	GGAGGACCTGGAGAGGAATGA	0.597000													3	18					3.59834e-05	3.66416e-05	1	1	0
SEMA6B	10501	broad.mit.edu	37	19	4556051	4556051	+	Silent	SNP	C	C	A	rs73527729	byFrequency	TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr19:4556051C>A	ENST00000586582.1	-	6	730	c.420G>T	c.(418-420)acG>acT	p.T140T	SEMA6B_ENST00000301293.3_Silent_p.T140T|SEMA6B_ENST00000586965.1_Silent_p.T140T	NM_032108.3	NP_115484.2	Q9H3T3	SEM6B_HUMAN	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B	140	Sema.				cell differentiation|nervous system development	integral to membrane	receptor activity			breast(1)|central_nervous_system(2)|large_intestine(4)|lung(11)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	21		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0149)|STAD - Stomach adenocarcinoma(1328;0.18)		ACACAAAGAGCGTGGACTCGT	0.627000													48	45					3.68337e-26	4.05576e-26	1	1	0
CDH9	1007	broad.mit.edu	37	5	26902796	26902796	+	Missense_Mutation	SNP	C	C	T			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr5:26902796C>T	ENST00000231021.4	-	7	1214	c.1042G>A	c.(1042-1044)Gat>Aat	p.D348N		NM_016279.3	NP_057363.3	Q9ULB4	CADH9_HUMAN	cadherin 9, type 2 (T1-cadherin)	348	Cadherin 3.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(6)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(25)|lung(80)|ovary(5)|prostate(4)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	137						TTACTTGCATCCACTCTTAAA	0.348000													9	35					0	0	1	0	0
OR8H3	390152	broad.mit.edu	37	11	55890226	55890226	+	Silent	SNP	C	C	T			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr11:55890226C>T	ENST00000313472.3	+	1	378	c.378C>T	c.(376-378)atC>atT	p.I126I		NM_001005201.1	NP_001005201.1	Q8N146	OR8H3_HUMAN	olfactory receptor, family 8, subfamily H, member 3	126					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(30)|ovary(2)|prostate(1)|skin(3)|stomach(1)	42	Esophageal squamous(21;0.00693)					ATGCAGCGATCTGCAGTCCTC	0.478000													70	102					0	0	1	0	0
WDR33	55339	broad.mit.edu	37	2	128477565	128477565	+	Silent	SNP	C	C	T			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr2:128477565C>T	ENST00000322313.4	-	16	2192	c.2034G>A	c.(2032-2034)caG>caA	p.Q678Q		NM_018383.4	NP_060853.3	Q9C0J8	WDR33_HUMAN	WD repeat domain 33	678	Collagen-like.				postreplication repair|spermatogenesis	collagen|nucleus	protein binding			NS(1)|breast(3)|endometrium(2)|kidney(2)|large_intestine(9)|lung(17)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	39	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0695)		CAGGATGCCTCTGCATTCCTT	0.642000													9	35					0	0	1	0	0
RNF19A	25897	broad.mit.edu	37	8	101273810	101273810	+	Missense_Mutation	SNP	C	C	A			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr8:101273810C>A	ENST00000519449.1	-	9	1958	c.1642G>T	c.(1642-1644)Ggg>Tgg	p.G548W	RNF19A_ENST00000341084.2_Missense_Mutation_p.G548W|RNF19A_ENST00000523255.1_5'UTR	NM_001280539.1|NM_015435.3	NP_001267468.1|NP_056250.3	Q9NV58	RN19A_HUMAN	ring finger protein 19A, RBR E3 ubiquitin protein ligase	548					microtubule cytoskeleton organization|protein modification process	centrosome|integral to membrane	ligase activity|transcription factor binding|zinc ion binding			breast(3)|central_nervous_system(1)|endometrium(4)|large_intestine(5)|lung(11)|ovary(2)|pancreas(1)|prostate(2)|skin(1)	30	all_cancers(14;3.5e-05)|all_epithelial(15;8.91e-08)|Lung NSC(17;0.000615)|all_lung(17;0.00166)		Epithelial(11;3.06e-11)|all cancers(13;5.78e-09)|OV - Ovarian serous cystadenocarcinoma(57;2.24e-05)|STAD - Stomach adenocarcinoma(118;0.0525)			GACAGACTCCCCGTTATACTG	0.463000													42	232					9.39024e-22	1.02719e-21	1	1	0
RBBP8NL	140893	broad.mit.edu	37	20	60994684	60994684	+	Missense_Mutation	SNP	G	G	A			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr20:60994684G>A	ENST00000252998.1	-	2	176	c.20C>T	c.(19-21)tCg>tTg	p.S7L		NM_080833.2	NP_543023.2			RBBP8 N-terminal like																		CCTGTTCAGCGACTCCATGAA	0.647000													32	61					0	0	1	0	0
DCHS2	54798	broad.mit.edu	37	4	155256083	155256083	+	Missense_Mutation	SNP	A	A	T			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr4:155256083A>T	ENST00000357232.4	-	8	1152	c.1153T>A	c.(1153-1155)Tta>Ata	p.L385I	DCHS2_ENST00000507542.1_5'UTR|DCHS2_ENST00000339452.1_Missense_Mutation_p.L884I	NM_017639.3	NP_060109.2	Q6V1P9	PCD23_HUMAN	dachsous cadherin-related 2		Cadherin 3.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(3)|endometrium(8)|kidney(5)|large_intestine(54)|lung(63)|ovary(4)|pancreas(1)|prostate(14)|skin(12)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	176	all_hematologic(180;0.208)	Renal(120;0.0854)		LUSC - Lung squamous cell carcinoma(193;0.107)		TCATAAACTAAGAAAGTGTAC	0.438000													40	6					0	0	1	0	0
MED13	9969	broad.mit.edu	37	17	60033093	60033093	+	Silent	SNP	G	G	A			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr17:60033093G>A	ENST00000397786.2	-	25	5806	c.5730C>T	c.(5728-5730)ctC>ctT	p.L1910L		NM_005121.2	NP_005112.2	Q9UHV7	MED13_HUMAN	mediator complex subunit 13	1910					androgen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			breast(4)|central_nervous_system(1)|endometrium(10)|kidney(24)|large_intestine(15)|liver(1)|lung(20)|ovary(1)|prostate(3)|skin(2)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	88						AGCAAGCACTGAGAATGCTAG	0.418000													22	68					0	0	1	0	0
GATAD2B	57459	broad.mit.edu	37	1	153782755	153782755	+	Silent	SNP	G	G	A			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr1:153782755G>A	ENST00000368655.4	-	11	1923	c.1680C>T	c.(1678-1680)atC>atT	p.I560I		NM_020699.2	NP_065750.1	Q8WXI9	P66B_HUMAN	GATA zinc finger domain containing 2B	560						nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(5)|lung(12)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	38	all_lung(78;1.34e-32)|Lung NSC(65;1.04e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)			TGTGTCCTCCGATGCCAGTAT	0.488000													19	61					0	0	1	0	0
MYO1A	4640	broad.mit.edu	37	12	57432257	57432257	+	Missense_Mutation	SNP	A	A	T			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr12:57432257A>T	ENST00000442789.2	-	18	1986	c.1699T>A	c.(1699-1701)Ttc>Atc	p.F567I	MYO1A_ENST00000300119.3_Missense_Mutation_p.F567I|MYO1A_ENST00000476795.1_5'UTR|MYO1A_ENST00000544473.1_Missense_Mutation_p.F405I	NM_001256041.1	NP_001242970.1	Q9UBC5	MYO1A_HUMAN	myosin IA	567	Myosin head-like.				sensory perception of sound|vesicle localization	brush border|cortical actin cytoskeleton|filamentous actin|lateral plasma membrane|microvillus|myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			breast(1)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(12)|lung(17)|ovary(2)|skin(7)|urinary_tract(3)	50						GAACTCTTGAACTGGGCCCCA	0.557000													35	26					0	0	1	0	0
ARMC8	25852	broad.mit.edu	37	3	137983015	137983015	+	Silent	SNP	C	C	G			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr3:137983015C>G	ENST00000469044.1	+	14	1531	c.1260C>G	c.(1258-1260)acC>acG	p.T420T	NME9_ENST00000341790.5_Intron|NME9_ENST00000383180.2_Intron|NME9_ENST00000484930.1_Intron|NME9_ENST00000536478.1_Intron|NME9_ENST00000317876.4_Intron|ARMC8_ENST00000461822.1_Silent_p.T353T|ARMC8_ENST00000485396.1_Silent_p.T347T|ARMC8_ENST00000491704.1_Silent_p.T378T|ARMC8_ENST00000481646.1_Silent_p.T406T|ARMC8_ENST00000393058.3_Silent_p.T410T|ARMC8_ENST00000538260.1_Silent_p.T389T	NM_001267041.1|NM_001267042.1	NP_001253970.1|NP_001253971.1	Q8IUR7	ARMC8_HUMAN	armadillo repeat containing 8	420							binding			endometrium(2)|kidney(1)|large_intestine(7)|lung(5)|upper_aerodigestive_tract(1)	16						AGCTTCGAACCAGTTTCCAGG	0.393000													27	25					0	0	1	0	0
RALGAPB	57148	broad.mit.edu	37	20	37203508	37203508	+	Silent	SNP	G	G	A			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr20:37203508G>A	ENST00000262879.6	+	30	4667	c.4383G>A	c.(4381-4383)caG>caA	p.Q1461Q	RALGAPB_ENST00000397042.3_Silent_p.Q1458Q|RALGAPB_ENST00000397040.1_Silent_p.Q1461Q|RALGAPB_ENST00000490114.1_3'UTR|RALGAPB_ENST00000397038.1_Silent_p.Q1240Q			Q86X10	RLGPB_HUMAN	Ral GTPase activating protein, beta subunit (non-catalytic)	1461					activation of Ral GTPase activity	intracellular	protein heterodimerization activity|Ral GTPase activator activity			breast(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(8)|lung(29)|ovary(1)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	65						GCCGGAAACAGAAAATCACCG	0.453000													44	30					0	0	1	0	0
BZRAP1	9256	broad.mit.edu	37	17	56385246	56385246	+	Silent	SNP	C	C	T			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr17:56385246C>T	ENST00000355701.3	-	23	5658	c.4788G>A	c.(4786-4788)caG>caA	p.Q1596Q	BZRAP1_ENST00000343736.4_Silent_p.Q1596Q|BZRAP1_ENST00000268893.6_Silent_p.Q1536Q	NM_001261835.1|NM_004758.3	NP_001248764.1|NP_004749.2	O95153	RIMB1_HUMAN	benzodiazapine receptor (peripheral) associated protein 1	1596						mitochondrion	benzodiazepine receptor binding			cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|liver(2)|lung(16)|ovary(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	54	Medulloblastoma(34;0.127)|all_neural(34;0.237)					CACCTCTCTTCTGGGGGCCCC	0.627000													8	39					0	0	1	0	0
ZNF273	10793	broad.mit.edu	37	7	64389235	64389235	+	Missense_Mutation	SNP	G	G	A			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr7:64389235G>A	ENST00000476120.1	+	4	1600	c.1529G>A	c.(1528-1530)gGa>gAa	p.G510E	ZNF273_ENST00000527278.1_3'UTR|ZNF273_ENST00000319636.5_Missense_Mutation_p.G445E	NM_021148.2	NP_066971.2	Q14593	ZN273_HUMAN	zinc finger protein 273	510					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(3)|prostate(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	16		Lung NSC(55;0.0295)|all_lung(88;0.0691)				ATTCATACTGGAGAGAAGCCC	0.378000													58	10					0	0	1	0	0
MOGS	7841	broad.mit.edu	37	2	74688445	74688445	+	Missense_Mutation	SNP	C	C	T			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr2:74688445C>T	ENST00000233616.4	-	4	2633	c.2471G>A	c.(2470-2472)gGc>gAc	p.G824D	MOGS_ENST00000452063.2_Missense_Mutation_p.G718D|MOGS_ENST00000409065.1_3'UTR	NM_006302.2	NP_006293.2	Q13724	MOGS_HUMAN	mannosyl-oligosaccharide glucosidase	824					oligosaccharide metabolic process|post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane|integral to membrane|membrane fraction	mannosyl-oligosaccharide glucosidase activity			cervix(1)|endometrium(6)|large_intestine(3)|lung(10)|prostate(1)|urinary_tract(2)	23						GCTGGTCCAGCCGTGGAAAGG	0.592000													10	39					0	0	1	0	0
RABEP2	79874	broad.mit.edu	37	16	28922244	28922244	+	Missense_Mutation	SNP	C	C	G			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr16:28922244C>G	ENST00000358201.4	-	7	1642	c.1054G>C	c.(1054-1056)Gtg>Ctg	p.V352L	RABEP2_ENST00000357573.6_Missense_Mutation_p.V320L|RABEP2_ENST00000544477.1_Missense_Mutation_p.V281L	NM_024816.2	NP_079092.2	Q9H5N1	RABE2_HUMAN	rabaptin, RAB GTPase binding effector protein 2	352					endocytosis|protein transport	early endosome	growth factor activity|GTPase activator activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(3)|lung(6)|ovary(1)|skin(1)	16						GCCTGGCTCACGGTCCCTTGC	0.657000													15	65					0	0	1	0	0
DNAJC3	5611	broad.mit.edu	37	13	96361567	96361567	+	Missense_Mutation	SNP	T	T	G			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr13:96361567T>G	ENST00000602402.1	+	2	286	c.169T>G	c.(169-171)Tta>Gta	p.L57V	DNAJC3_ENST00000376795.6_Missense_Mutation_p.L57V	NM_006260.4	NP_006251.1	Q13217	DNJC3_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 3	57					protein folding|response to unfolded protein|response to virus		heat shock protein binding|protein kinase inhibitor activity|unfolded protein binding			NS(1)|breast(1)|kidney(4)|large_intestine(1)|lung(4)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	15	all_neural(89;0.0878)|Breast(111;0.148)|Medulloblastoma(90;0.163)		BRCA - Breast invasive adenocarcinoma(86;0.126)			AGCTGATGCTTTATCTCAGTT	0.358000													15	19					0	0	1	0	0
CPSF1	29894	broad.mit.edu	37	8	145622095	145622095	+	Missense_Mutation	SNP	G	G	A			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr8:145622095G>A	ENST00000349769.3	-	24	2736	c.2642C>T	c.(2641-2643)tCt>tTt	p.S881F		NM_013291.2	NP_037423.2	Q10570	CPSF1_HUMAN	cleavage and polyadenylation specific factor 1, 160kDa	881					mRNA cleavage|mRNA export from nucleus|mRNA polyadenylation|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	mRNA cleavage and polyadenylation specificity factor complex	mRNA 3'-UTR binding|protein binding			NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(5)|lung(15)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	38	all_cancers(97;6.64e-12)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.88e-41)|Epithelial(56;1.67e-40)|all cancers(56;1.2e-35)|BRCA - Breast invasive adenocarcinoma(115;0.0323)|Colorectal(110;0.055)			GCCGAGCTGAGAGTCGTGGGG	0.602000													11	39					0	0	1	0	0
RYR3	6263	broad.mit.edu	37	15	33955875	33955875	+	Silent	SNP	G	G	A			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr15:33955875G>A	ENST00000389232.4	+	36	5626	c.5556G>A	c.(5554-5556)ctG>ctA	p.L1852L	RYR3_ENST00000415757.3_Silent_p.L1852L	NM_001036.3	NP_001027.3	Q15413	RYR3_HUMAN	ryanodine receptor 3	1852	4 X approximate repeats.				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity	p.L1852L(2)		NS(3)|breast(9)|central_nervous_system(8)|cervix(2)|endometrium(29)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(55)|lung(148)|ovary(7)|pancreas(1)|prostate(13)|skin(4)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(3)	311		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		TGCAGGCCCTGAACATGTCTG	0.567000													8	2					0	0	1	0	0
EXOC1	55763	broad.mit.edu	37	4	56758876	56758876	+	Splice_Site	SNP	G	G	A			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr4:56758876G>A	ENST00000381295.2	+	14	2071	c.1723G>A	c.(1723-1725)Gag>Aag	p.E575K	EXOC1_ENST00000349598.6_Splice_Site_p.E560K|EXOC1_ENST00000346134.7_Splice_Site_p.E575K	NM_001024924.1	NP_001020095.1	Q9NV70	EXOC1_HUMAN	exocyst complex component 1	575					exocytosis|protein transport	exocyst	protein binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(3)|lung(14)|ovary(2)|skin(4)|upper_aerodigestive_tract(1)	35	Glioma(25;0.08)|all_neural(26;0.101)					TGTTTCATCTGAGTATGTCTT	0.398000													18	85					0	0	1	0	0
PCCA	5095	broad.mit.edu	37	13	100953732	100953732	+	Missense_Mutation	SNP	G	G	C			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr13:100953732G>C	ENST00000376285.1	+	13	1122	c.1084G>C	c.(1084-1086)Gaa>Caa	p.E362Q	PCCA_ENST00000376286.4_Missense_Mutation_p.E336Q|PCCA_ENST00000376279.3_Missense_Mutation_p.E362Q	NM_000282.3	NP_000273.2	P05165	PCCA_HUMAN	propionyl CoA carboxylase, alpha polypeptide	362	ATP-grasp.|Biotin carboxylation.				fatty acid beta-oxidation	mitochondrial matrix	ATP binding|biotin binding|biotin carboxylase activity|enzyme binding|metal ion binding|propionyl-CoA carboxylase activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(12)|lung(8)|prostate(1)|skin(2)	26	all_neural(89;0.0837)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)				Biotin(DB00121)	TCCTGTCACAGAATGCATTAC	0.458000													21	63					0	0	1	0	0
SNED1	25992	broad.mit.edu	37	2	241974125	241974125	+	Silent	SNP	C	C	T			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr2:241974125C>T	ENST00000310397.8	+	4	783	c.783C>T	c.(781-783)cgC>cgT	p.R261R	AC005237.4_ENST00000458377.1_RNA|SNED1_ENST00000401884.1_Silent_p.R261R|SNED1_ENST00000342631.6_Silent_p.R261R|SNED1_ENST00000405547.3_Silent_p.R261R	NM_001080437.1	NP_001073906.1	Q8TER0	SNED1_HUMAN	sushi, nidogen and EGF-like domains 1	261					cell-matrix adhesion	extracellular region	calcium ion binding			NS(1)|breast(1)|central_nervous_system(3)|kidney(2)|large_intestine(6)|lung(4)|ovary(3)|prostate(3)|upper_aerodigestive_tract(1)	24		all_cancers(19;7.48e-31)|all_epithelial(40;1.35e-12)|Breast(86;0.000148)|Renal(207;0.00528)|Ovarian(221;0.104)|Esophageal squamous(248;0.131)|all_lung(227;0.17)|all_hematologic(139;0.182)|Melanoma(123;0.238)		Epithelial(32;6.46e-32)|all cancers(36;6.23e-29)|OV - Ovarian serous cystadenocarcinoma(60;2.1e-14)|Kidney(56;6.35e-09)|KIRC - Kidney renal clear cell carcinoma(57;5.98e-08)|BRCA - Breast invasive adenocarcinoma(100;3.66e-06)|Lung(119;0.00072)|LUSC - Lung squamous cell carcinoma(224;0.00553)|Colorectal(34;0.0162)|COAD - Colon adenocarcinoma(134;0.109)		CCCAGGTGCGCGTGGGGGGCT	0.657000													8	5					0	0	1	0	0
REXO2	25996	broad.mit.edu	37	11	114315274	114315274	+	Silent	SNP	C	C	G			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr11:114315274C>G	ENST00000265881.5	+	4	464	c.321C>G	c.(319-321)acC>acG	p.T107T	REXO2_ENST00000538791.1_Silent_p.T17T|REXO2_ENST00000539275.1_Intron|REXO2_ENST00000539754.1_Intron	NM_015523.3	NP_056338.2	Q9Y3B8	ORN_HUMAN	RNA exonuclease 2	107	Exonuclease.				nucleotide metabolic process	mitochondrion|nucleus	3'-5' exonuclease activity|nucleic acid binding			cervix(1)|endometrium(1)|kidney(1)|lung(1)	4		all_cancers(61;5.06e-12)|all_epithelial(67;5.3e-06)|all_hematologic(158;7.68e-05)|Acute lymphoblastic leukemia(157;0.000966)|Melanoma(852;0.00153)|Medulloblastoma(222;0.0523)|all_neural(223;0.0663)|Breast(348;0.0818)|Prostate(24;0.104)		BRCA - Breast invasive adenocarcinoma(274;2.65e-06)|Epithelial(105;6.09e-05)|all cancers(92;0.000494)		CTGGCCTTACCAAGGCAGTGA	0.453000													10	41					0	0	1	0	0
MACF1	23499	broad.mit.edu	37	1	39800589	39800589	+	Missense_Mutation	SNP	G	G	C			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr1:39800589G>C	ENST00000564288.1	+	37	9106	c.8329G>C	c.(8329-8331)Gaa>Caa	p.E2777Q	MACF1_ENST00000545844.1_Intron|MACF1_ENST00000372915.3_Missense_Mutation_p.E2782Q|MACF1_ENST00000361689.2_Intron|MACF1_ENST00000539005.1_Intron|MACF1_ENST00000567887.1_Missense_Mutation_p.E2814Q|MACF1_ENST00000289893.4_Missense_Mutation_p.E1217Q|MACF1_ENST00000317713.7_Intron|MACF1_ENST00000476350.1_Intron			Q9UPN3	MACF1_HUMAN	microtubule-actin crosslinking factor 1	2782					cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			breast(11)|central_nervous_system(5)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(36)|lung(78)|ovary(12)|prostate(2)|skin(9)|stomach(2)|upper_aerodigestive_tract(8)|urinary_tract(10)	203	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			TGAAAAGCAAGAAGGGATTGA	0.368000													25	226					0	0	1	0	0
HELZ	9931	broad.mit.edu	37	17	65103605	65103605	+	Missense_Mutation	SNP	T	T	C			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr17:65103605T>C	ENST00000358691.5	-	31	5087	c.4921A>G	c.(4921-4923)Att>Gtt	p.I1641V	HELZ_ENST00000580168.1_Missense_Mutation_p.I1642V	NM_014877.3	NP_055692			helicase with zinc finger											NS(1)|breast(5)|endometrium(9)|kidney(3)|large_intestine(11)|liver(1)|lung(24)|ovary(1)|pancreas(1)|prostate(1)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(2)	69	all_cancers(12;1.24e-11)|Breast(2;1.05e-17)|all_epithelial(3;3.87e-13)					GCTACTTCAATGTCTCTGCTG	0.502000													113	43					0	0	1	0	0
CBLN1	869	broad.mit.edu	37	16	49313318	49313318	+	Silent	SNP	G	G	C			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr16:49313318G>C	ENST00000219197.6	-	3	944	c.579C>G	c.(577-579)ctC>ctG	p.L193L	CBLN1_ENST00000536749.1_Silent_p.L193L	NM_004352.3	NP_004343.1	P23435	CBLN1_HUMAN	cerebellin 1 precursor	193	C1q.|Necessary for interaction with CBLN3, and homotrimerization (By similarity).				nervous system development|synaptic transmission	cell junction|extracellular region|synapse				breast(1)|kidney(3)|large_intestine(2)|lung(3)	9		all_cancers(37;0.0766)|all_lung(18;0.24)				GAGCCAGTCAGAGAGGAAACA	0.567000													17	47					0	0	1	0	0
PCDHGB4	8641	broad.mit.edu	37	5	140768277	140768277	+	Missense_Mutation	SNP	G	G	A			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr5:140768277G>A	ENST00000519479.1	+	1	826	c.826G>A	c.(826-828)Gag>Aag	p.E276K	PCDHGA2_ENST00000394576.2_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGB3_ENST00000576222.1_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGA6_ENST00000517434.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGA7_ENST00000518325.1_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGA4_ENST00000571252.1_Intron	NM_003736.2|NM_018925.2|NM_032098.1	NP_003727.1|NP_061748.1|NP_115269.1														endometrium(9)|kidney(3)|large_intestine(4)|lung(14)|ovary(1)|prostate(1)|stomach(3)|urinary_tract(2)	37			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGTCAATGCCGAGATTACTTT	0.468000													46	41					0	0	1	0	0
DSG4	147409	broad.mit.edu	37	18	28992885	28992885	+	Missense_Mutation	SNP	C	C	G			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr18:28992885C>G	ENST00000359747.4	+	15	2536	c.2507C>G	c.(2506-2508)tCt>tGt	p.S836C	RP11-534N16.1_ENST00000581856.1_RNA|DSG4_ENST00000308128.4_Missense_Mutation_p.S817C|RP11-534N16.1_ENST00000578477.1_RNA	NM_001134453.1	NP_001127925.1	Q86SJ6	DSG4_HUMAN	desmoglein 4	817					homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			NS(1)|breast(1)|central_nervous_system(6)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(11)|liver(2)|lung(35)|ovary(4)|skin(1)|stomach(1)|urinary_tract(1)	70			OV - Ovarian serous cystadenocarcinoma(10;0.00504)			CCCGTAGGCTCTATTGGTTGT	0.438000													20	51					0	0	1	0	0
CRAMP1L	57585	broad.mit.edu	37	16	1720696	1720696	+	Missense_Mutation	SNP	G	G	T			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr16:1720696G>T	ENST00000397412.3	+	20	3630	c.3531G>T	c.(3529-3531)aaG>aaT	p.K1177N	CRAMP1L_ENST00000262317.4_Missense_Mutation_p.K552N|LA16c-431H6.6_ENST00000454337.1_3'UTR|CRAMP1L_ENST00000293925.5_Missense_Mutation_p.K1177N|CRAMP1L_ENST00000436138.3_Missense_Mutation_p.K1174N			Q96RY5	CRML_HUMAN	Crm, cramped-like (Drosophila)	1177	Ser-rich.					nucleus	DNA binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(3)|lung(6)|pancreas(1)	22						AGAGCCGGAAGATGTTGCCGA	0.577000													86	82					1.11079e-38	1.23121e-38	1	1	0
NOA1	84273	broad.mit.edu	37	4	57842852	57842852	+	Silent	SNP	C	C	T			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr4:57842852C>T	ENST00000264230.4	-	1	2137	c.900G>A	c.(898-900)ccG>ccA	p.P300P		NM_032313.2	NP_115689.1	Q8NC60	CD014_HUMAN	nitric oxide associated 1	300							GTP binding										TCGGCGGATTCGGATTCTCCC	0.667000													15	46					0	0	1	0	0
VPS13C	54832	broad.mit.edu	37	15	62208206	62208206	+	Missense_Mutation	SNP	G	G	A	rs139139141	by1000genomes	TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr15:62208206G>A	ENST00000261517.5	-	61	8144	c.8071C>T	c.(8071-8073)Cat>Tat	p.H2691Y	VPS13C_ENST00000395898.3_Missense_Mutation_p.H2648Y|VPS13C_ENST00000249837.3_Missense_Mutation_p.H2648Y|VPS13C_ENST00000395896.4_Missense_Mutation_p.H2691Y	NM_020821.2	NP_065872.1	Q709C8	VP13C_HUMAN	vacuolar protein sorting 13 homolog C (S. cerevisiae)	2691					protein localization					NS(3)|breast(4)|endometrium(4)|kidney(9)|large_intestine(26)|lung(46)|ovary(5)|prostate(6)|skin(6)|stomach(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	117						GCCAGCTCATGAGTTTCTGCT	0.353000													13	22					0	0	1	0	0
EXOSC10	5394	broad.mit.edu	37	1	11140941	11140958	+	In_Frame_Del	DEL	TCATCCGTGAAGATAGGT	TCATCCGTGAAGATAGGT	-			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr1:11140941_11140958delTCATCCGTGAAGATAGGT	ENST00000544779.1	-	12	1454_1471	c.1449_1466delACCTATCTTCACGGATGA	c.(1447-1467)aaacctatcttcacggatgag>aag	p.PIFTDE484del	EXOSC10_ENST00000376936.4_In_Frame_Del_p.PIFTDE484del|EXOSC10_ENST00000485606.1_5'UTR|EXOSC10_ENST00000304457.7_In_Frame_Del_p.PIFTDE484del			Q01780	EXOSX_HUMAN	exosome component 10	484					CUT catabolic process|histone mRNA catabolic process|maturation of 5.8S rRNA|nuclear polyadenylation-dependent rRNA catabolic process|nuclear retention of unspliced pre-mRNA at the site of transcription|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	cytoplasm|nuclear exosome (RNase complex)|nucleolus|transcriptionally active chromatin	3'-5' exonuclease activity|exoribonuclease activity|identical protein binding|nucleotide binding|protein serine/threonine kinase activity|RNA binding			central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(9)|prostate(1)|stomach(3)|upper_aerodigestive_tract(1)	27	Ovarian(185;0.249)	Lung NSC(185;1.74e-05)|all_lung(284;2.05e-05)|Renal(390;0.000147)|Colorectal(325;0.00205)|Breast(348;0.00262)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;4.18e-07)|COAD - Colon adenocarcinoma(227;8.33e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000315)|Kidney(185;0.000832)|KIRC - Kidney renal clear cell carcinoma(229;0.00269)|READ - Rectum adenocarcinoma(331;0.0526)|STAD - Stomach adenocarcinoma(313;0.202)		AAGGTAGGACTCATCCGTGAAGATAGGTTTGATGAATT	0.422													8	156	---	---	---	---					
ERICH6-AS1	101928085	broad.mit.edu	37	3	150421899	150421900	+	RNA	INS	-	-	C	rs34009900	by1000genomes	TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr3:150421899_150421900insC	ENST00000475393.1	+	0	20				RP11-103G8.2_ENST00000471093.1_RNA																							TTCTGTCCCTGCTCTTCAGCGT	0.545													5	3	---	---	---	---					
AC005077.5	0	broad.mit.edu	37	7	75804673	75804673	+	RNA	DEL	A	A	-			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr7:75804673delA	ENST00000437494.1	+	0	57																											atctcgaaccaaaaaaaaaag	0.542													3	5	---	---	---	---					
PRSS3P2	154754	broad.mit.edu	37	7	142481923	142481925	+	RNA	DEL	CAA	CAA	-			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr7:142481923_142481925delCAA	ENST00000603901.1	+	0	591					NR_001296.3																						GTGATTAGACCAACCCTTCCCAT	0.537													2	4	---	---	---	---					
PRKDC	5591	broad.mit.edu	37	8	48695135	48695135	+	Frame_Shift_Del	DEL	T	T	-	rs139593183	by1000genomes	TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr8:48695135delT	ENST00000314191.2	-	80	11253	c.11197delA	c.(11197-11199)aggfs	p.R3733fs	PRKDC_ENST00000523565.1_5'UTR|PRKDC_ENST00000338368.3_Frame_Shift_Del_p.R3733fs	NM_006904.6	NP_008835.5	P78527	PRKDC_HUMAN	protein kinase, DNA-activated, catalytic polypeptide	3734					cellular response to insulin stimulus|double-strand break repair via nonhomologous end joining|peptidyl-serine phosphorylation|positive regulation of transcription from RNA polymerase II promoter	DNA-dependent protein kinase-DNA ligase 4 complex|transcription factor complex	ATP binding|DNA binding|DNA-dependent protein kinase activity|transcription factor binding			NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(9)|cervix(3)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(30)|lung(56)|ovary(6)|pancreas(1)|prostate(8)|skin(7)	147		all_cancers(86;0.0336)|all_epithelial(80;0.00111)|Lung NSC(129;0.00363)|all_lung(136;0.00391)				CGCTTGGGCCTTCGCAGAGAC	0.582								Non-homologous end-joining					2	4	---	---	---	---					
CEP164P1	100289237	broad.mit.edu	37	10	45566461	45566461	+	RNA	DEL	C	C	-			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr10:45566461delC	ENST00000456938.2	-	0	87																											ATATTTGTCACCCCCCATGTC	0.502													5	2	---	---	---	---					
ITPR2	3709	broad.mit.edu	37	12	26714878	26714879	+	Frame_Shift_Ins	INS	-	-	T			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr12:26714878_26714879insT	ENST00000381340.3	-	35	5053_5054	c.4637_4638insA	c.(4636-4638)aatfs	p.N1546fs		NM_002223.2	NP_002214.2	Q14571	ITPR2_HUMAN	inositol 1,4,5-trisphosphate receptor, type 2	1546					activation of phospholipase C activity|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	integral to membrane|plasma membrane enriched fraction|platelet dense tubular network membrane|sarcoplasmic reticulum membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity		ETV6/ITPR2(2)	biliary_tract(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(16)|large_intestine(20)|liver(1)|lung(51)|ovary(5)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(5)|urinary_tract(3)	125	Colorectal(261;0.0847)					CAATTCCACGATTTTTTGCTGA	0.322													10	21	---	---	---	---					
MLST8	64223	broad.mit.edu	37	16	2258555	2258562	+	Frame_Shift_Del	DEL	CCTCCCGC	CCTCCCGC	-			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr16:2258555_2258562delCCTCCCGC	ENST00000569417.1	+	8	1157_1164	c.803_810delCCTCCCGC	c.(802-810)tcctcccgcfs	p.SSR268fs	MLST8_ENST00000382450.4_Frame_Shift_Del_p.SSR267fs|MLST8_ENST00000397124.1_Frame_Shift_Del_p.SSR268fs|MLST8_ENST00000301725.7_3'UTR|MLST8_ENST00000565250.1_Frame_Shift_Del_p.SSR268fs|MLST8_ENST00000301724.10_Frame_Shift_Del_p.SSR268fs|MLST8_ENST00000564088.1_Frame_Shift_Del_p.SSR268fs	NM_022372.4	NP_071767.3	Q9BVC4	LST8_HUMAN	MTOR associated protein, LST8 homolog (S. cerevisiae)	268					insulin receptor signaling pathway|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of TOR signaling cascade|T cell costimulation	cytosol	protein binding			large_intestine(3)|lung(2)|skin(1)	6						CCCGGGGAGTCCTCCCGCGGCTGGATGT	0.678													18	123	---	---	---	---					
ALDOA	226	broad.mit.edu	37	16	30080142	30080150	+	In_Frame_Del	DEL	TGGATGGGC	TGGATGGGC	-	rs121909533		TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr16:30080142_30080150delTGGATGGGC	ENST00000566897.1	+	8	1535_1543	c.383_391delTGGATGGGC	c.(382-393)ttggatgggctg>ttg	p.128_131LDGL>L	ALDOA_ENST00000569545.1_In_Frame_Del_p.128_131LDGL>L|ALDOA_ENST00000563060.2_In_Frame_Del_p.128_131LDGL>L|ALDOA_ENST00000395240.3_In_Frame_Del_p.128_131LDGL>L|ALDOA_ENST00000564546.1_In_Frame_Del_p.128_131LDGL>L|ALDOA_ENST00000412304.2_In_Frame_Del_p.128_131LDGL>L|ALDOA_ENST00000564595.2_In_Frame_Del_p.182_185LDGL>L|ALDOA_ENST00000338110.5_In_Frame_Del_p.128_131LDGL>L|ALDOA_ENST00000569798.1_In_Frame_Del_p.128_131LDGL>L|ALDOA_ENST00000395248.1_In_Frame_Del_p.182_185LDGL>L			P04075	ALDOA_HUMAN	aldolase A, fructose-bisphosphate	128					actin filament organization|ATP biosynthetic process|fructose 1,6-bisphosphate metabolic process|gluconeogenesis|glycolysis|muscle cell homeostasis|platelet activation|platelet degranulation|protein homotetramerization|regulation of cell shape|striated muscle contraction	actin cytoskeleton|cytosol|extracellular vesicular exosome|I band|platelet alpha granule lumen	actin binding|fructose binding|fructose-bisphosphate aldolase activity|identical protein binding|tubulin binding	p.D129H(1)		breast(2)|cervix(1)|endometrium(4)|large_intestine(1)|lung(6)|prostate(2)|upper_aerodigestive_tract(1)	17						CTCTTAGGGTTGGATGGGCTGTCTGAGCG	0.598											OREG0023729	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	9	102	---	---	---	---					
PDXDC2P	283970	broad.mit.edu	37	16	70066043	70066043	+	RNA	DEL	A	A	-			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr16:70066043delA	ENST00000531894.1	-	0	751					NR_003610.1																						AGCCAAGCCGAAAAAAAAAAA	0.289													4	7	---	---	---	---					
BAGE2	85319	broad.mit.edu	37	21	11085863	11085864	+	RNA	INS	-	-	C			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr21:11085863_11085864insC	ENST00000470054.1	-	0	324									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		catcaccaccaccaccatcacc	0.579													2	4	---	---	---	---					
AP001604.3	0	broad.mit.edu	37	21	28793489	28793490	+	RNA	INS	-	-	T	rs144948060		TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chr21:28793489_28793490insT	ENST00000420186.2	-	0	202																											atttttttttcttttttttttt	0.347													3	5	---	---	---	---					
DGKK	139189	broad.mit.edu	37	X	50213577	50213600	+	RNA	DEL	GGCGGCGGCGGCCAAGGCGGCGGA	GGCGGCGGCGGCCAAGGCGGCGGA	-			TCGA-K4-A6MB-01A-11D-A31L-08	TCGA-K4-A6MB-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61fee403-3f4d-449d-9cac-40142b3f3c99	d6709e93-f67c-4e98-9dc3-bc4db2061a7c	g.chrX:50213577_50213600delGGCGGCGGCGGCCAAGGCGGCGGA	ENST00000376025.2	-	0	137_160							Q5KSL6	DGKK_HUMAN	diacylglycerol kinase, kappa						activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|diacylglycerol metabolic process|intracellular signal transduction|platelet activation|response to oxidative stress	cytoplasm|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			central_nervous_system(1)|endometrium(12)|kidney(4)|large_intestine(5)|lung(18)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	45	Ovarian(276;0.236)					cggtggtggtggcggcggcggccaaggcggcggaggcTCTGGAG	0.719													7	9	---	---	---	---