Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
SPRY3	10251	broad.mit.edu	37	X	155004068	155004068	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-A8HH-01A-11D-A38G-08	TCGA-XF-A8HH-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f221f317-1da7-437b-9810-d18cc320e339	77ece96f-b1b7-413e-af73-03c11a8f5e91	g.chrX:155004068G>A	ENST00000302805.2	+	2	966	c.535G>A	c.(535-537)Gag>Aag	p.E179K		NM_005840.1	NP_005831.1	O43610	SPY3_HUMAN	sprouty homolog 3 (Drosophila)	179	Cys-rich.|SPR.				multicellular organismal development|regulation of signal transduction	cytoplasm|membrane						all_cancers(53;1.86e-17)|all_epithelial(53;2.71e-11)|all_lung(58;1.84e-07)|Lung NSC(58;5.62e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)					TTGCTCTGCTGAGAGCCTCCT	0.587000													39	71					0	0	1	0	0
BTN2A3P	54718	broad.mit.edu	37	6	26422353	26422353	+	RNA	SNP	C	C	T	rs141013110		TCGA-XF-A8HH-01A-11D-A38G-08	TCGA-XF-A8HH-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f221f317-1da7-437b-9810-d18cc320e339	77ece96f-b1b7-413e-af73-03c11a8f5e91	g.chr6:26422353C>T	ENST00000466808.2	+	0	7																		p.P3S(2)									GCTCATGGAACCAGCTGCTGC	0.622000													3	57					0	0	1	0	0
LIPE	3991	broad.mit.edu	37	19	42910512	42910512	+	Silent	SNP	C	C	T			TCGA-XF-A8HH-01A-11D-A38G-08	TCGA-XF-A8HH-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f221f317-1da7-437b-9810-d18cc320e339	77ece96f-b1b7-413e-af73-03c11a8f5e91	g.chr19:42910512C>T	ENST00000244289.4	-	7	2442	c.2166G>A	c.(2164-2166)gcG>gcA	p.A722A	LIPE-AS1_ENST00000594624.2_RNA|LIPE-AS1_ENST00000593491.2_RNA|LIPE-AS1_ENST00000597203.1_RNA|LIPE-AS1_ENST00000599276.1_RNA	NM_005357.2	NP_005348.2	Q05469	LIPS_HUMAN	lipase, hormone-sensitive	722					cholesterol metabolic process|protein phosphorylation|triglyceride catabolic process	caveola|cytosol	hormone-sensitive lipase activity|protein binding			breast(2)|endometrium(4)|kidney(7)|large_intestine(6)|lung(8)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	32		Prostate(69;0.00682)				CACTGTCCCCCGCAAGGCAGA	0.662000													6	20					0	0	1	0	0
TRPM1	4308	broad.mit.edu	37	15	31360178	31360178	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-A8HH-01A-11D-A38G-08	TCGA-XF-A8HH-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f221f317-1da7-437b-9810-d18cc320e339	77ece96f-b1b7-413e-af73-03c11a8f5e91	g.chr15:31360178C>G	ENST00000542188.1	-	4	761	c.448G>C	c.(448-450)Gag>Cag	p.E150Q	TRPM1_ENST00000397795.2_Missense_Mutation_p.E111Q|TRPM1_ENST00000256552.6_Missense_Mutation_p.E133Q	NM_001252020.1	NP_001238949.1	Q7Z4N2	TRPM1_HUMAN	transient receptor potential cation channel, subfamily M, member 1	111					cellular response to light stimulus|visual perception	integral to plasma membrane	calcium channel activity|receptor activity			NS(2)|breast(3)|central_nervous_system(3)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(15)|lung(48)|ovary(2)|pancreas(1)|prostate(3)|skin(2)|soft_tissue(1)|upper_aerodigestive_tract(3)	99		all_lung(180;1.92e-11)		all cancers(64;3.52e-16)|Epithelial(43;1.65e-11)|GBM - Glioblastoma multiforme(186;3.57e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00533)|COAD - Colon adenocarcinoma(236;0.0609)|Lung(196;0.199)		GGCTGCATCTCAAAGTTCTGG	0.532000													28	76					0	0	1	0	0
ENPP2	5168	broad.mit.edu	37	8	120631527	120631527	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-A8HH-01A-11D-A38G-08	TCGA-XF-A8HH-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f221f317-1da7-437b-9810-d18cc320e339	77ece96f-b1b7-413e-af73-03c11a8f5e91	g.chr8:120631527C>G	ENST00000427067.2	-	5	604	c.424G>C	c.(424-426)Gat>Cat	p.D142H	ENPP2_ENST00000522826.1_Missense_Mutation_p.D146H|ENPP2_ENST00000075322.6_Missense_Mutation_p.D146H|ENPP2_ENST00000259486.6_Missense_Mutation_p.D146H			Q13822	ENPP2_HUMAN	ectonucleotide pyrophosphatase/phosphodiesterase 2	146	SMB 2.				cellular component movement|chemotaxis|G-protein coupled receptor protein signaling pathway|immune response|phosphate metabolic process|phosphatidylcholine catabolic process|regulation of cell migration	extracellular space|integral to plasma membrane	alkylglycerophosphoethanolamine phosphodiesterase activity|calcium ion binding|lysophospholipase activity|nucleic acid binding|nucleotide diphosphatase activity|phosphodiesterase I activity|polysaccharide binding|scavenger receptor activity|transcription factor binding|zinc ion binding			breast(1)|central_nervous_system(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(15)|lung(30)|ovary(2)|prostate(2)|skin(4)|upper_aerodigestive_tract(4)	69	Lung NSC(37;5.03e-06)|Ovarian(258;0.0249)|Hepatocellular(40;0.161)		STAD - Stomach adenocarcinoma(47;0.00185)			CAGTCATCATCAACCCAATGC	0.383000													17	47					0	0	1	0	0
PNRC1	10957	broad.mit.edu	37	6	89790845	89790845	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-A8HH-01A-11D-A38G-08	TCGA-XF-A8HH-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f221f317-1da7-437b-9810-d18cc320e339	77ece96f-b1b7-413e-af73-03c11a8f5e91	g.chr6:89790845C>G	ENST00000336032.3	+	1	349	c.232C>G	c.(232-234)Ctg>Gtg	p.L78V	PNRC1_ENST00000369472.1_Intron	NM_006813.2	NP_006804.1	Q12796	PNRC1_HUMAN	proline-rich nuclear receptor coactivator 1	78					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding			endometrium(1)|large_intestine(2)|lung(3)	6		all_cancers(76;3.64e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00527)		BRCA - Breast invasive adenocarcinoma(108;0.102)		TCCAGCAGCTCTGCCCAACCG	0.716000										Multiple Myeloma(7;0.094)			4	2					0	0	1	0	0
TYW1B	441250	broad.mit.edu	37	7	72081774	72081774	+	RNA	SNP	A	A	G	rs3015854	by1000genomes	TCGA-XF-A8HH-01A-11D-A38G-08	TCGA-XF-A8HH-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f221f317-1da7-437b-9810-d18cc320e339	77ece96f-b1b7-413e-af73-03c11a8f5e91	g.chr7:72081774A>G	ENST00000343721.5	-	0	851				TYW1B_ENST00000438125.1_RNA|TYW1B_ENST00000435769.2_RNA			Q6NUM6	TYW1B_HUMAN	tRNA-yW synthesizing protein 1 homolog B (S. cerevisiae)						tRNA processing		4 iron, 4 sulfur cluster binding|FMN binding|iron ion binding|oxidoreductase activity										GCCAGGGCACATGGGCCATGG	0.493000													11	53					0	0	1	0	0
ANKRD36C	400986	broad.mit.edu	37	2	96523187	96523187	+	Missense_Mutation	SNP	T	T	C			TCGA-XF-A8HH-01A-11D-A38G-08	TCGA-XF-A8HH-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f221f317-1da7-437b-9810-d18cc320e339	77ece96f-b1b7-413e-af73-03c11a8f5e91	g.chr2:96523187T>C	ENST00000456556.1	-	62	4034	c.3950A>G	c.(3949-3951)cAa>cGa	p.Q1317R	ANKRD36C_ENST00000420871.2_Missense_Mutation_p.Q568R|ANKRD36C_ENST00000419039.2_Missense_Mutation_p.Q344R					ankyrin repeat domain 36C											breast(1)|endometrium(8)|kidney(5)|lung(4)	18						CCTAACTTTTTGGTGCAACTC	0.343000													6	15					0	0	1	0	0
TBC1D20	128637	broad.mit.edu	37	20	419427	419427	+	Missense_Mutation	SNP	T	T	G			TCGA-XF-A8HH-01A-11D-A38G-08	TCGA-XF-A8HH-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f221f317-1da7-437b-9810-d18cc320e339	77ece96f-b1b7-413e-af73-03c11a8f5e91	g.chr20:419427T>G	ENST00000354200.4	-	8	1162	c.1015A>C	c.(1015-1017)Atg>Ctg	p.M339L	TBC1D20_ENST00000461188.1_5'UTR	NM_144628.2	NP_653229.1	Q96BZ9	TBC20_HUMAN	TBC1 domain family, member 20	339					interspecies interaction between organisms	integral to membrane|intracellular	Rab GTPase activator activity			central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(2)|skin(1)|upper_aerodigestive_tract(1)	12		all_epithelial(17;0.228)|Breast(17;0.231)				CGCAGCACCATATCAGGCCTC	0.537000													38	77					0	0	1	0	0
LAMA4	3910	broad.mit.edu	37	6	112575049	112575049	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-A8HH-01A-11D-A38G-08	TCGA-XF-A8HH-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f221f317-1da7-437b-9810-d18cc320e339	77ece96f-b1b7-413e-af73-03c11a8f5e91	g.chr6:112575049C>G	ENST00000368638.4	-	2	574	c.304G>C	c.(304-306)Gag>Cag	p.E102Q	RP11-506B6.6_ENST00000590293.1_RNA|RP11-506B6.6_ENST00000588837.1_RNA|LAMA4_ENST00000424408.2_Intron|RP11-506B6.6_ENST00000590804.1_RNA|LAMA4_ENST00000230538.7_Intron|LAMA4_ENST00000389463.4_Intron|LAMA4_ENST00000431543.2_Intron|RP11-506B6.6_ENST00000585504.1_RNA|RP11-506B6.6_ENST00000433684.3_RNA|LAMA4_ENST00000453937.2_Missense_Mutation_p.E102Q|RP11-506B6.6_ENST00000590673.1_RNA|RP11-506B6.6_ENST00000585611.1_RNA|RP11-506B6.6_ENST00000590584.1_RNA|RP11-506B6.6_ENST00000587816.1_RNA|LAMA4_ENST00000522006.1_Intron|RP11-506B6.6_ENST00000585450.1_RNA			Q16363	LAMA4_HUMAN	laminin, alpha 4	0	Laminin EGF-like 1.				cell adhesion|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	extracellular matrix structural constituent|receptor binding			NS(1)|breast(6)|central_nervous_system(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|lung(42)|ovary(4)|pancreas(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(8)	100		all_cancers(87;0.000196)|all_hematologic(75;0.000114)|all_epithelial(87;0.00542)|Colorectal(196;0.0209)		all cancers(137;0.0335)|OV - Ovarian serous cystadenocarcinoma(136;0.0578)|Epithelial(106;0.0748)|BRCA - Breast invasive adenocarcinoma(108;0.242)		GTGAAACTCTCAAGGCACTGG	0.542000													5	26					0	0	1	0	0
TMTC1	83857	broad.mit.edu	37	12	29911635	29911635	+	Splice_Site	SNP	A	A	T			TCGA-XF-A8HH-01A-11D-A38G-08	TCGA-XF-A8HH-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f221f317-1da7-437b-9810-d18cc320e339	77ece96f-b1b7-413e-af73-03c11a8f5e91	g.chr12:29911635A>T	ENST00000256062.5	-	3	704		c.e3+1		TMTC1_ENST00000551659.1_Splice_Site|TMTC1_ENST00000381224.2_Splice_Site|TMTC1_ENST00000539277.1_Splice_Site|TMTC1_ENST00000552618.1_Splice_Site	NM_175861.3	NP_787057.2	Q8IUR5	TMTC1_HUMAN	transmembrane and tetratricopeptide repeat containing 1							integral to membrane	binding			breast(1)|endometrium(4)|kidney(3)|large_intestine(17)|lung(45)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	75	Lung NSC(12;7.61e-10)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.032)					AGCTACACATACCTGTTGTAC	0.473000													3	19					0	0	1	0	0
HK3	3101	broad.mit.edu	37	5	176314551	176314551	+	Nonsense_Mutation	SNP	G	G	A			TCGA-XF-A8HH-01A-11D-A38G-08	TCGA-XF-A8HH-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f221f317-1da7-437b-9810-d18cc320e339	77ece96f-b1b7-413e-af73-03c11a8f5e91	g.chr5:176314551G>A	ENST00000292432.5	-	11	1592	c.1501C>T	c.(1501-1503)Cag>Tag	p.Q501*		NM_002115.2	NP_002106.2	P52790	HXK3_HUMAN	hexokinase 3 (white cell)	501	Catalytic.				glucose transport|glycolysis|transmembrane transport	cytosol|membrane	ATP binding|glucokinase activity			breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(21)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	47	all_cancers(89;0.000104)|Renal(175;0.000269)|Lung NSC(126;0.00696)|all_lung(126;0.0115)	Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			ATCTGTGCCTGAACCGCAGCC	0.682000													9	29					0	0	1	0	0
CTSH	1512	broad.mit.edu	37	15	79224774	79224774	+	Silent	SNP	G	G	A			TCGA-XF-A8HH-01A-11D-A38G-08	TCGA-XF-A8HH-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f221f317-1da7-437b-9810-d18cc320e339	77ece96f-b1b7-413e-af73-03c11a8f5e91	g.chr15:79224774G>A	ENST00000220166.5	-	6	541	c.432C>T	c.(430-432)ttC>ttT	p.F144F	CTSH_ENST00000534533.1_5'UTR	NM_004390.3	NP_004381.2	P09668	CATH_HUMAN	cathepsin H	144					protein destabilization|proteolysis	lysosome	cysteine-type endopeptidase activity			central_nervous_system(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(1)	10						CAGTGGTGGAGAAAGTCCAGC	0.622000													5	24					0	0	1	0	0
C1orf106	55765	broad.mit.edu	37	1	200877971	200877971	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-A8HH-01A-11D-A38G-08	TCGA-XF-A8HH-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f221f317-1da7-437b-9810-d18cc320e339	77ece96f-b1b7-413e-af73-03c11a8f5e91	g.chr1:200877971G>A	ENST00000367342.4	+	7	1143	c.943G>A	c.(943-945)Gaa>Aaa	p.E315K	C1orf106_ENST00000413687.2_Missense_Mutation_p.E230K	NM_018265.3	NP_060735.3	Q3KP66	CA106_HUMAN	chromosome 1 open reading frame 106	315	Pro-rich.									endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(6)|ovary(1)|prostate(2)|skin(3)|stomach(1)|urinary_tract(2)	21						TGGGAGCCCAGAACGGGCTCC	0.627000													15	41					0	0	1	0	0
PHF6	84295	broad.mit.edu	37	X	133527538	133527538	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-A8HH-01A-11D-A38G-08	TCGA-XF-A8HH-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f221f317-1da7-437b-9810-d18cc320e339	77ece96f-b1b7-413e-af73-03c11a8f5e91	g.chrX:133527538C>T	ENST00000332070.3	+	4	450	c.248C>T	c.(247-249)tCt>tTt	p.S83F	PHF6_ENST00000416404.2_Missense_Mutation_p.S49F|PHF6_ENST00000370799.1_Missense_Mutation_p.S83F|PHF6_ENST00000370803.3_Missense_Mutation_p.S83F|PHF6_ENST00000394292.1_Missense_Mutation_p.S83F|PHF6_ENST00000370800.4_Missense_Mutation_p.S83F	NM_032458.2	NP_115834.1	Q8IWS0	PHF6_HUMAN	PHD finger protein 6	83					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus	zinc ion binding			cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(88)|kidney(2)|large_intestine(1)|liver(1)|lung(6)|ovary(1)|skin(1)|urinary_tract(1)	103	Acute lymphoblastic leukemia(192;0.000127)					TAGATGTGTTCTTTGTGCCAT	0.368000			"""F, N, Splice, Mis"""		ETP ALL								40	68					0	0	1	0	0
LRP6	4040	broad.mit.edu	37	12	12301926	12301926	+	Silent	SNP	C	C	G			TCGA-XF-A8HH-01A-11D-A38G-08	TCGA-XF-A8HH-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f221f317-1da7-437b-9810-d18cc320e339	77ece96f-b1b7-413e-af73-03c11a8f5e91	g.chr12:12301926C>G	ENST00000261349.4	-	14	3232	c.3156G>C	c.(3154-3156)ctG>ctC	p.L1052L	LRP6_ENST00000543091.1_Silent_p.L1052L	NM_002336.2	NP_002327.2	O75581	LRP6_HUMAN	low density lipoprotein receptor-related protein 6	1052	Beta-propeller 4.				cellular response to cholesterol|negative regulation of protein phosphorylation|negative regulation of protein serine/threonine kinase activity|negative regulation of smooth muscle cell apoptosis|neural crest formation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell cycle|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway involved in dorsal/ventral axis specification|Wnt receptor signaling pathway involved in dorsal/ventral axis specification	cell surface|cytoplasmic vesicle|endoplasmic reticulum|integral to membrane|plasma membrane	coreceptor activity|frizzled binding|kinase inhibitor activity|low-density lipoprotein receptor activity|protein homodimerization activity|toxin transporter activity|Wnt-protein binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(19)|lung(28)|ovary(3)|prostate(2)|skin(7)|upper_aerodigestive_tract(5)|urinary_tract(1)	85		Prostate(47;0.0865)				GCTCGCCTTTCAGCACCACTC	0.473000													39	101					0	0	1	0	0
GGT1	2678	broad.mit.edu	37	22	25010755	25010755	+	Silent	SNP	G	G	A			TCGA-XF-A8HH-01A-11D-A38G-08	TCGA-XF-A8HH-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f221f317-1da7-437b-9810-d18cc320e339	77ece96f-b1b7-413e-af73-03c11a8f5e91	g.chr22:25010755G>A	ENST00000400382.1	+	6	932	c.177G>A	c.(175-177)cgG>cgA	p.R59R	GGT1_ENST00000406383.2_Silent_p.R59R|GGT1_ENST00000248923.4_Silent_p.R59R|GGT1_ENST00000400380.1_Silent_p.R59R|GGT1_ENST00000400383.1_Silent_p.R59R			P19440	GGT1_HUMAN	gamma-glutamyltransferase 1	59					glutathione biosynthetic process	integral to membrane	acyltransferase activity|gamma-glutamyltransferase activity|protein binding			breast(1)|endometrium(2)|kidney(14)|large_intestine(2)|lung(6)|pancreas(1)|prostate(6)|skin(7)|upper_aerodigestive_tract(1)	40					Glutathione(DB00143)	ATGCACTGCGGGACGGTGGCT	0.627000													10	27					0	0	1	0	0
ACSF2	80221	broad.mit.edu	37	17	48551110	48551110	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-A8HH-01A-11D-A38G-08	TCGA-XF-A8HH-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f221f317-1da7-437b-9810-d18cc320e339	77ece96f-b1b7-413e-af73-03c11a8f5e91	g.chr17:48551110C>G	ENST00000427954.2	+	14	1678	c.1635C>G	c.(1633-1635)atC>atG	p.I545M	ACSF2_ENST00000506085.1_3'UTR|ACSF2_ENST00000300441.4_Missense_Mutation_p.I520M|ACSF2_ENST00000504392.1_Missense_Mutation_p.I477M|ACSF2_ENST00000541920.1_Missense_Mutation_p.I360M|ACSF2_ENST00000502667.1_Missense_Mutation_p.I507M			Q96CM8	ACSF2_HUMAN	acyl-CoA synthetase family member 2	520					fatty acid metabolic process	mitochondrion	ATP binding|ligase activity			endometrium(7)|kidney(3)|large_intestine(1)|lung(1)|stomach(1)	13	Breast(11;1.93e-18)		BRCA - Breast invasive adenocarcinoma(22;1.55e-09)			GTGAGAACATCTACCCCGCAG	0.547000													10	99					0	0	1	0	0
TNXB	7148	broad.mit.edu	37	6	32032767	32032767	+	Silent	SNP	G	G	A			TCGA-XF-A8HH-01A-11D-A38G-08	TCGA-XF-A8HH-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f221f317-1da7-437b-9810-d18cc320e339	77ece96f-b1b7-413e-af73-03c11a8f5e91	g.chr6:32032767G>A	ENST00000375244.3	-	19	6873	c.6672C>T	c.(6670-6672)ttC>ttT	p.F2224F	TNXB_ENST00000375247.2_Silent_p.F2224F			P22105	TENX_HUMAN	tenascin XB	2296	Fibronectin type-III 14.				actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|prostate(1)	8						ACTGGACCAAGAAATGGTCAA	0.612000													12	22					0	0	1	0	0
DMC1	11144	broad.mit.edu	37	22	38917725	38917725	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-A8HH-01A-11D-A38G-08	TCGA-XF-A8HH-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f221f317-1da7-437b-9810-d18cc320e339	77ece96f-b1b7-413e-af73-03c11a8f5e91	g.chr22:38917725G>C	ENST00000216024.2	-	13	1117	c.841C>G	c.(841-843)Cag>Gag	p.Q281E	DMC1_ENST00000428462.2_Missense_Mutation_p.Q226E	NM_007068.2	NP_008999.2	Q14565	DMC1_HUMAN	DNA meiotic recombinase 1	281					reciprocal meiotic recombination	condensed nuclear chromosome	ATP binding|DNA binding|DNA-dependent ATPase activity|protein binding			large_intestine(5)|lung(4)|ovary(1)|upper_aerodigestive_tract(1)	11	Melanoma(58;0.0286)					GGATCTGCCTGAAAGCTGAAT	0.408000								Homologous recombination					35	93					0	0	1	0	0
ZNF507	22847	broad.mit.edu	37	19	32845418	32845418	+	Missense_Mutation	SNP	A	A	G			TCGA-XF-A8HH-01A-11D-A38G-08	TCGA-XF-A8HH-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f221f317-1da7-437b-9810-d18cc320e339	77ece96f-b1b7-413e-af73-03c11a8f5e91	g.chr19:32845418A>G	ENST00000311921.4	+	2	1874	c.1682A>G	c.(1681-1683)aAc>aGc	p.N561S	ZNF507_ENST00000544431.1_Missense_Mutation_p.N561S|ZNF507_ENST00000355898.5_Missense_Mutation_p.N561S	NM_001136156.1|NM_014910.4	NP_001129628.1|NP_055725.2	Q8TCN5	ZN507_HUMAN	zinc finger protein 507						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(2)|breast(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(10)|ovary(1)|pancreas(1)|skin(2)|urinary_tract(1)	31	Esophageal squamous(110;0.162)					AACCAAAGCAACTCCACCTTG	0.438000													4	47					0	0	1	0	0
B4GALT3	8703	broad.mit.edu	37	1	161143713	161143713	+	Silent	SNP	G	G	A			TCGA-XF-A8HH-01A-11D-A38G-08	TCGA-XF-A8HH-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f221f317-1da7-437b-9810-d18cc320e339	77ece96f-b1b7-413e-af73-03c11a8f5e91	g.chr1:161143713G>A	ENST00000319769.5	-	5	838	c.616C>T	c.(616-618)Ctg>Ttg	p.L206L	B4GALT3_ENST00000470882.1_5'UTR|PPOX_ENST00000495483.1_Intron|PPOX_ENST00000432542.2_Intron|B4GALT3_ENST00000367998.1_Silent_p.L206L|PPOX_ENST00000535223.1_Intron	NM_001199873.1|NM_003779.3	NP_001186802.1|NP_003770.1	O60512	B4GT3_HUMAN	UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 3	206					post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi cisterna membrane|integral to membrane	beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity|metal ion binding|N-acetyllactosamine synthase activity			cervix(1)|endometrium(5)|large_intestine(6)|lung(6)	18	all_cancers(52;3.73e-19)|Breast(13;0.000577)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00275)		N-Acetyl-D-glucosamine(DB00141)	CACACATACAGATTGTGGTCA	0.537000													14	43					0	0	1	0	0
BZRAP1	9256	broad.mit.edu	37	17	56386652	56386652	+	Silent	SNP	C	C	T			TCGA-XF-A8HH-01A-11D-A38G-08	TCGA-XF-A8HH-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f221f317-1da7-437b-9810-d18cc320e339	77ece96f-b1b7-413e-af73-03c11a8f5e91	g.chr17:56386652C>T	ENST00000355701.3	-	22	4851	c.3981G>A	c.(3979-3981)aaG>aaA	p.K1327K	BZRAP1_ENST00000268893.6_Silent_p.K1267K|BZRAP1_ENST00000343736.4_Silent_p.K1327K	NM_001261835.1|NM_004758.3	NP_001248764.1|NP_004749.2	O95153	RIMB1_HUMAN	benzodiazapine receptor (peripheral) associated protein 1	1327						mitochondrion	benzodiazepine receptor binding			cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|liver(2)|lung(16)|ovary(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	54	Medulloblastoma(34;0.127)|all_neural(34;0.237)					TAAAGAGCTTCTTGCTACAGA	0.602000													6	34					0	0	1	0	0
ARID2	196528	broad.mit.edu	37	12	46298726	46298726	+	Silent	SNP	G	G	A			TCGA-XF-A8HH-01A-11D-A38G-08	TCGA-XF-A8HH-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f221f317-1da7-437b-9810-d18cc320e339	77ece96f-b1b7-413e-af73-03c11a8f5e91	g.chr12:46298726G>A	ENST00000334344.6	+	21	5545	c.5373G>A	c.(5371-5373)aaG>aaA	p.K1791K	ARID2_ENST00000479608.1_3'UTR|ARID2_ENST00000457135.1_3'UTR|ARID2_ENST00000444670.1_Silent_p.K1401K	NM_152641.2	NP_689854.2	Q68CP9	ARID2_HUMAN	AT rich interactive domain 2 (ARID, RFX-like)	1791					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(7)|central_nervous_system(3)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(21)|liver(20)|lung(34)|ovary(7)|pancreas(1)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	116	Lung SC(27;0.192)|Renal(347;0.236)	Lung NSC(34;0.106)|all_lung(34;0.22)	OV - Ovarian serous cystadenocarcinoma(5;0.00691)	GBM - Glioblastoma multiforme(48;0.0153)		GATTGTTAAAGAGACATGAAA	0.338000			"""N, S, F"""		hepatocellular carcinoma								5	24					0	0	1	0	0
GRHL2	79977	broad.mit.edu	37	8	102589686	102589686	+	Silent	SNP	C	C	G			TCGA-XF-A8HH-01A-11D-A38G-08	TCGA-XF-A8HH-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f221f317-1da7-437b-9810-d18cc320e339	77ece96f-b1b7-413e-af73-03c11a8f5e91	g.chr8:102589686C>G	ENST00000251808.3	+	7	1280	c.942C>G	c.(940-942)ctC>ctG	p.L314L	GRHL2_ENST00000395927.1_Silent_p.L298L	NM_024915.3	NP_079191.2	Q6ISB3	GRHL2_HUMAN	grainyhead-like 2 (Drosophila)	314						cytoplasm|nucleus	DNA binding			breast(3)|central_nervous_system(1)|endometrium(3)|large_intestine(6)|liver(2)|lung(6)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	28	all_cancers(14;4.39e-08)|all_epithelial(15;4.09e-10)|Lung NSC(17;7.11e-06)|all_lung(17;1.44e-05)		Epithelial(11;5.81e-09)|all cancers(13;3.81e-07)|OV - Ovarian serous cystadenocarcinoma(57;0.000213)			ATGAACAGCTCAAATACTGGA	0.473000													10	113					0	0	1	0	0
JMY	133746	broad.mit.edu	37	5	78610630	78610630	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-A8HH-01A-11D-A38G-08	TCGA-XF-A8HH-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f221f317-1da7-437b-9810-d18cc320e339	77ece96f-b1b7-413e-af73-03c11a8f5e91	g.chr5:78610630G>A	ENST00000396137.4	+	9	3077	c.2615G>A	c.(2614-2616)cGg>cAg	p.R872Q	JMY_ENST00000412001.1_Intron	NM_152405.4	NP_689618.4	Q8N9B5	JMY_HUMAN	junction mediating and regulatory protein, p53 cofactor	872					'de novo' actin filament nucleation|actin polymerization-dependent cell motility|Arp2/3 complex-mediated actin nucleation|cell cycle arrest|DNA repair|induction of apoptosis|positive regulation of sequence-specific DNA binding transcription factor activity|regulation of transcription from RNA polymerase II promoter	cell leading edge|cytoplasm|cytoskeleton|nucleus	actin binding|transcription coactivator activity			endometrium(4)|kidney(2)|large_intestine(2)|lung(6)|skin(1)|urinary_tract(1)	16		all_lung(232;0.00051)|Lung NSC(167;0.00131)|Ovarian(174;0.0261)|Prostate(461;0.191)		OV - Ovarian serous cystadenocarcinoma(54;4.45e-45)|Epithelial(54;5.85e-40)|all cancers(79;2.89e-35)		GTCAGTGCACGGAAGAAGCTC	0.488000													6	21					0	0	1	0	0
LEPRE1	64175	broad.mit.edu	37	1	43232181	43232181	+	Missense_Mutation	SNP	G	G	T			TCGA-XF-A8HH-01A-11D-A38G-08	TCGA-XF-A8HH-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f221f317-1da7-437b-9810-d18cc320e339	77ece96f-b1b7-413e-af73-03c11a8f5e91	g.chr1:43232181G>T	ENST00000236040.4	-	1	502	c.462C>A	c.(460-462)ttC>ttA	p.F154L	LEPRE1_ENST00000397054.3_Missense_Mutation_p.F154L|LEPRE1_ENST00000296388.5_Missense_Mutation_p.F154L	NM_001243246.1	NP_001230175.1	Q32P28	P3H1_HUMAN	leucine proline-enriched proteoglycan (leprecan) 1	154					negative regulation of cell proliferation	endoplasmic reticulum|proteinaceous extracellular matrix	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-proline 3-dioxygenase activity			large_intestine(2)|lung(15)|ovary(5)|prostate(1)|urinary_tract(3)	26	Ovarian(52;0.00744)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)			L-Proline(DB00172)|Succinic acid(DB00139)|Vitamin C(DB00126)	TCTGCACCTTGAAGTAGGCGA	0.672000													3	8					6.4e-05	6.63558e-05	1	1	0
TPCN2	219931	broad.mit.edu	37	11	68822696	68822696	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-A8HH-01A-11D-A38G-08	TCGA-XF-A8HH-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f221f317-1da7-437b-9810-d18cc320e339	77ece96f-b1b7-413e-af73-03c11a8f5e91	g.chr11:68822696C>T	ENST00000294309.3	+	4	406	c.305C>T	c.(304-306)cCa>cTa	p.P102L	TPCN2_ENST00000442692.2_3'UTR|TPCN2_ENST00000542467.1_Missense_Mutation_p.P102L	NM_139075.3	NP_620714.2	Q8NHX9	TPC2_HUMAN	two pore segment channel 2	102					cellular calcium ion homeostasis|smooth muscle contraction	endosome membrane|integral to membrane|lysosomal membrane	NAADP-sensitive calcium-release channel activity|voltage-gated calcium channel activity			breast(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(17)|prostate(2)|skin(1)|urinary_tract(1)	32			STAD - Stomach adenocarcinoma(18;0.0208)|LUAD - Lung adenocarcinoma(13;0.0713)			ATCGAGACCCCATCCTCACTC	0.592000													43	121					0	0	1	0	0
ERBB3	2065	broad.mit.edu	37	12	56488228	56488228	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-A8HH-01A-11D-A38G-08	TCGA-XF-A8HH-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f221f317-1da7-437b-9810-d18cc320e339	77ece96f-b1b7-413e-af73-03c11a8f5e91	g.chr12:56488228C>T	ENST00000267101.3	+	15	2187	c.1747C>T	c.(1747-1749)Ccc>Tcc	p.P583S	ERBB3_ENST00000450146.2_Intron|ERBB3_ENST00000415288.2_Missense_Mutation_p.P524S	NM_001982.3	NP_001973.2	P21860	ERBB3_HUMAN	v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3	583					cranial nerve development|heart development|negative regulation of cell adhesion|negative regulation of neuron apoptosis|negative regulation of secretion|negative regulation of signal transduction|neuron apoptosis|phosphatidylinositol 3-kinase cascade|positive regulation of phosphatidylinositol 3-kinase cascade|regulation of cell proliferation|Schwann cell differentiation|transmembrane receptor protein tyrosine kinase signaling pathway|wound healing	basolateral plasma membrane|extracellular space|integral to plasma membrane|receptor complex	ATP binding|growth factor binding|protein heterodimerization activity|protein homodimerization activity|protein tyrosine kinase activator activity|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			central_nervous_system(2)|lung(3)|ovary(1)|skin(1)|stomach(1)	8			OV - Ovarian serous cystadenocarcinoma(18;0.112)			TCGAGATGGGCCCCACTGTGT	0.527000													17	82					0	0	1	0	0
LOC146880	146880	broad.mit.edu	37	17	62758676	62758676	+	RNA	SNP	C	C	G			TCGA-XF-A8HH-01A-11D-A38G-08	TCGA-XF-A8HH-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f221f317-1da7-437b-9810-d18cc320e339	77ece96f-b1b7-413e-af73-03c11a8f5e91	g.chr17:62758676C>G	ENST00000400873.3	-	0	1269					NR_026899.1																						GGTGCTTATTCAAAGCAAATG	0.413000													3	30					0	0	1	0	0
IBTK	25998	broad.mit.edu	37	6	82950048	82950048	+	Silent	SNP	G	G	A			TCGA-XF-A8HH-01A-11D-A38G-08	TCGA-XF-A8HH-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f221f317-1da7-437b-9810-d18cc320e339	77ece96f-b1b7-413e-af73-03c11a8f5e91	g.chr6:82950048G>A	ENST00000306270.7	-	2	705	c.156C>T	c.(154-156)ggC>ggT	p.G52G	IBTK_ENST00000510291.1_Silent_p.G52G|IBTK_ENST00000503631.1_Silent_p.G52G	NM_015525.2	NP_056340.2	Q9P2D0	IBTK_HUMAN	inhibitor of Bruton agammaglobulinemia tyrosine kinase	52					negative regulation of protein phosphorylation|release of sequestered calcium ion into cytosol	cytoplasm|membrane|nucleus	protein kinase binding|protein tyrosine kinase inhibitor activity			central_nervous_system(2)|endometrium(9)|kidney(3)|large_intestine(10)|lung(19)|ovary(3)|pancreas(1)|prostate(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	54		all_cancers(76;3.38e-06)|Acute lymphoblastic leukemia(125;3.41e-06)|all_hematologic(105;0.000865)|all_epithelial(107;0.0037)		BRCA - Breast invasive adenocarcinoma(397;0.0901)		GGGCATTCCTGCCAAAAACAT	0.443000													4	40					0	0	1	0	0
SPATA31D1	389763	broad.mit.edu	37	9	84606360	84606360	+	Silent	SNP	G	G	A			TCGA-XF-A8HH-01A-11D-A38G-08	TCGA-XF-A8HH-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f221f317-1da7-437b-9810-d18cc320e339	77ece96f-b1b7-413e-af73-03c11a8f5e91	g.chr9:84606360G>A	ENST00000344803.2	+	4	1022	c.975G>A	c.(973-975)ccG>ccA	p.P325P		NM_001001670.2	NP_001001670.1			SPATA31 subfamily D, member 1																		AGACTTTTCCGGAAATGTTAT	0.483000													46	109					0	0	1	0	0
TMEM184C	55751	broad.mit.edu	37	4	148545957	148545957	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-A8HH-01A-11D-A38G-08	TCGA-XF-A8HH-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f221f317-1da7-437b-9810-d18cc320e339	77ece96f-b1b7-413e-af73-03c11a8f5e91	g.chr4:148545957G>C	ENST00000296582.3	+	4	868	c.294G>C	c.(292-294)tgG>tgC	p.W98C	TMEM184C_ENST00000508208.1_Missense_Mutation_p.W98C	NM_018241.2	NP_060711.2	Q9NVA4	T184C_HUMAN	transmembrane protein 184C	98						integral to membrane				breast(2)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(4)|lung(2)|prostate(1)	16						TTTCATAGTGGATAGCTTTGA	0.338000													6	32					0	0	1	0	0
DUOXA2	405753	broad.mit.edu	37	15	45409319	45409319	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-A8HH-01A-11D-A38G-08	TCGA-XF-A8HH-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f221f317-1da7-437b-9810-d18cc320e339	77ece96f-b1b7-413e-af73-03c11a8f5e91	g.chr15:45409319C>G	ENST00000323030.5	+	5	870	c.585C>G	c.(583-585)aaC>aaG	p.N195K		NM_207581.3	NP_997464.2	Q1HG44	DOXA2_HUMAN	dual oxidase maturation factor 2	195					protein transport	endoplasmic reticulum membrane|integral to membrane							all_cancers(109;5.7e-11)|all_epithelial(112;4.65e-09)|Lung NSC(122;3.55e-06)|all_lung(180;2.56e-05)|Melanoma(134;0.027)		all cancers(107;2.88e-18)|GBM - Glioblastoma multiforme(94;3.95e-07)|COAD - Colon adenocarcinoma(120;0.0652)|Colorectal(133;0.0659)		TCCTCTCCAACGTGCTGCTCT	0.692000													4	26					0	0	1	0	0
PPM1H	57460	broad.mit.edu	37	12	63195765	63195765	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-A8HH-01A-11D-A38G-08	TCGA-XF-A8HH-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f221f317-1da7-437b-9810-d18cc320e339	77ece96f-b1b7-413e-af73-03c11a8f5e91	g.chr12:63195765G>C	ENST00000228705.6	-	3	887	c.587C>G	c.(586-588)cCt>cGt	p.P196R		NM_020700.1	NP_065751.1	Q9ULR3	PPM1H_HUMAN	protein phosphatase, Mg2+/Mn2+ dependent, 1H	196	PP2C-like.						phosphoprotein phosphatase activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(9)|ovary(1)	18			GBM - Glioblastoma multiforme(1;0.000443)|BRCA - Breast invasive adenocarcinoma(9;0.209)	GBM - Glioblastoma multiforme(28;0.0126)		CGTGTTCTCAGGCTCCTCCCC	0.706000													13	55					0	0	1	0	0
CFL1	1072	broad.mit.edu	37	11	65623477	65623477	+	Silent	SNP	G	G	A			TCGA-XF-A8HH-01A-11D-A38G-08	TCGA-XF-A8HH-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f221f317-1da7-437b-9810-d18cc320e339	77ece96f-b1b7-413e-af73-03c11a8f5e91	g.chr11:65623477G>A	ENST00000525451.2	-	3	955	c.240C>T	c.(238-240)tgC>tgT	p.C80C	CFL1_ENST00000531407.1_Silent_p.C63C|CFL1_ENST00000308162.5_Silent_p.C80C|CFL1_ENST00000527344.1_Silent_p.C63C|CFL1_ENST00000531413.1_Silent_p.C63C|CFL1_ENST00000524553.1_Silent_p.C63C|CFL1_ENST00000534769.1_Silent_p.C118C			P23528	COF1_HUMAN	cofilin 1 (non-muscle)	80	ADF-H.				actin cytoskeleton organization|anti-apoptosis|axon guidance|platelet activation|platelet degranulation|response to virus|Rho protein signal transduction	cytoplasm|cytoskeleton|nuclear matrix	actin binding			breast(1)|kidney(1)|large_intestine(2)|lung(2)	6				READ - Rectum adenocarcinoma(159;0.169)		GGGCATAGCGGCAGTCCTTAT	0.542000													31	72					0	0	1	0	0
DHX30	22907	broad.mit.edu	37	3	47887807	47887807	+	Silent	SNP	G	G	A			TCGA-XF-A8HH-01A-11D-A38G-08	TCGA-XF-A8HH-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f221f317-1da7-437b-9810-d18cc320e339	77ece96f-b1b7-413e-af73-03c11a8f5e91	g.chr3:47887807G>A	ENST00000446256.2	+	12	1700	c.1128G>A	c.(1126-1128)caG>caA	p.Q376Q	DHX30_ENST00000445061.1_Silent_p.Q415Q|DHX30_ENST00000457607.1_Silent_p.Q443Q|DHX30_ENST00000348968.4_Silent_p.Q387Q	NM_014966.3	NP_055781.2	Q7L2E3	DHX30_HUMAN	DEAH (Asp-Glu-Ala-His) box helicase 30	415						mitochondrial nucleoid	ATP binding|ATP-dependent helicase activity|protein binding|RNA binding			endometrium(3)|kidney(1)|large_intestine(11)|lung(13)|ovary(4)|pancreas(1)|prostate(1)|skin(3)	37				BRCA - Breast invasive adenocarcinoma(193;0.000696)|KIRC - Kidney renal clear cell carcinoma(197;0.00609)|Kidney(197;0.007)		GTCTCAGCCAGAGTCTGCTAG	0.622000													27	84					0	0	1	0	0
OLAH	55301	broad.mit.edu	37	10	15089297	15089297	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-A8HH-01A-11D-A38G-08	TCGA-XF-A8HH-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f221f317-1da7-437b-9810-d18cc320e339	77ece96f-b1b7-413e-af73-03c11a8f5e91	g.chr10:15089297G>A	ENST00000378217.3	+	2	197	c.10G>A	c.(10-12)Gga>Aga	p.G4R	OLAH_ENST00000378228.3_Missense_Mutation_p.G4R	NM_018324.2	NP_060794.1	Q9NV23	SAST_HUMAN	oleoyl-ACP hydrolase	4					fatty acid biosynthetic process		myristoyl-[acyl-carrier-protein] hydrolase activity|oleoyl-[acyl-carrier-protein] hydrolase activity|palmitoyl-[acyl-carrier-protein] hydrolase activity			endometrium(2)|large_intestine(1)|lung(14)|stomach(1)	18						CATGGAGAGAGGAGACCAACC	0.562000													3	2					0	0	1	0	0
LOC146880	146880	broad.mit.edu	37	17	62758790	62758790	+	RNA	SNP	C	C	T			TCGA-XF-A8HH-01A-11D-A38G-08	TCGA-XF-A8HH-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f221f317-1da7-437b-9810-d18cc320e339	77ece96f-b1b7-413e-af73-03c11a8f5e91	g.chr17:62758790C>T	ENST00000400873.3	-	0	1155					NR_026899.1																						TTTCGGTGCTCAACCGTGAAA	0.363000													4	32					0	0	1	0	0
DNAJC13	23317	broad.mit.edu	37	3	132226191	132226191	+	Silent	SNP	A	A	G			TCGA-XF-A8HH-01A-11D-A38G-08	TCGA-XF-A8HH-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f221f317-1da7-437b-9810-d18cc320e339	77ece96f-b1b7-413e-af73-03c11a8f5e91	g.chr3:132226191A>G	ENST00000260818.6	+	43	5357	c.5109A>G	c.(5107-5109)caA>caG	p.Q1703Q		NM_015268.3	NP_056083.3	O75165	DJC13_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 13	1703							heat shock protein binding			breast(4)|endometrium(2)|kidney(2)|large_intestine(5)|lung(15)|ovary(1)|pancreas(2)|prostate(2)|urinary_tract(1)	34						CTACTTTCCAACTGGAGGTAA	0.343000													35	92					0	0	1	0	0
SMTNL1	219537	broad.mit.edu	37	11	57311169	57311169	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-A8HH-01A-11D-A38G-08	TCGA-XF-A8HH-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f221f317-1da7-437b-9810-d18cc320e339	77ece96f-b1b7-413e-af73-03c11a8f5e91	g.chr11:57311169C>T	ENST00000457912.1	+	3	859	c.859C>T	c.(859-861)Ccc>Tcc	p.P287S	SMTNL1_ENST00000527972.1_Missense_Mutation_p.P269S|SMTNL1_ENST00000399154.2_Missense_Mutation_p.P232S			E9PPJ3	E9PPJ3_HUMAN	smoothelin-like 1	269										endometrium(2)|large_intestine(1)|lung(4)|ovary(1)	8						AGGGGTGATTCCCAGCTCCCC	0.637000													3	9					0	0	1	0	0
MACF1	23499	broad.mit.edu	37	1	39847678	39847678	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-A8HH-01A-11D-A38G-08	TCGA-XF-A8HH-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f221f317-1da7-437b-9810-d18cc320e339	77ece96f-b1b7-413e-af73-03c11a8f5e91	g.chr1:39847678G>C	ENST00000564288.1	+	56	14479	c.13702G>C	c.(13702-13704)Gag>Cag	p.E4568Q	MACF1_ENST00000372915.3_Missense_Mutation_p.E4573Q|MACF1_ENST00000289893.4_Missense_Mutation_p.E3008Q|MACF1_ENST00000539005.1_Missense_Mutation_p.E2485Q|MACF1_ENST00000545844.1_Missense_Mutation_p.E2506Q|MACF1_ENST00000361689.2_Missense_Mutation_p.E2506Q|MACF1_ENST00000317713.7_Missense_Mutation_p.E2506Q|MACF1_ENST00000567887.1_Missense_Mutation_p.E4605Q			Q9UPN3	MACF1_HUMAN	microtubule-actin crosslinking factor 1	4573					cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			breast(11)|central_nervous_system(5)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(36)|lung(78)|ovary(12)|prostate(2)|skin(9)|stomach(2)|upper_aerodigestive_tract(8)|urinary_tract(10)	203	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			AAGGCAGCTAGAGGAATCTGC	0.532000													19	50					0	0	1	0	0
PI4K2A	55361	broad.mit.edu	37	10	99416706	99416706	+	Silent	SNP	G	G	T			TCGA-XF-A8HH-01A-11D-A38G-08	TCGA-XF-A8HH-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f221f317-1da7-437b-9810-d18cc320e339	77ece96f-b1b7-413e-af73-03c11a8f5e91	g.chr10:99416706G>T	ENST00000370631.3	+	4	954	c.897G>T	c.(895-897)gtG>gtT	p.V299V	PI4K2A_ENST00000555577.1_Silent_p.V269V|PI4K2A_ENST00000370649.3_Silent_p.V269V	NM_018425.2	NP_060895.1	Q9BTU6	P4K2A_HUMAN	phosphatidylinositol 4-kinase type 2 alpha	299	PI3K/PI4K.				phosphatidylinositol biosynthetic process	cytoplasm|integral to plasma membrane|membrane raft	1-phosphatidylinositol 4-kinase activity|ATP binding|magnesium ion binding			endometrium(2)|kidney(1)|large_intestine(3)|lung(3)|ovary(1)|prostate(1)|skin(1)	12		Colorectal(252;0.162)		Epithelial(162;1.24e-10)|all cancers(201;1.2e-08)		GGTTGGTGGTGCTGGATTACA	0.562000													9	34					0.0692343	0.0696464	1	1	0
STOM	2040	broad.mit.edu	37	9	124110341	124110341	+	Silent	SNP	C	C	T			TCGA-XF-A8HH-01A-11D-A38G-08	TCGA-XF-A8HH-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f221f317-1da7-437b-9810-d18cc320e339	77ece96f-b1b7-413e-af73-03c11a8f5e91	g.chr9:124110341C>T	ENST00000286713.2	-	6	629	c.612G>A	c.(610-612)caG>caA	p.Q204Q	AL161784.1_ENST00000594963.1_Silent_p.L37L|STOM_ENST00000347359.2_Intron|STOM_ENST00000538954.1_Silent_p.Q153Q	NM_001270526.1|NM_004099.5	NP_001257455.1|NP_004090.4	P27105	STOM_HUMAN	stomatin	204					protein homooligomerization	cytoskeleton|integral to plasma membrane|melanosome|membrane raft	protein binding			endometrium(1)|large_intestine(1)|lung(3)|urinary_tract(1)	6				OV - Ovarian serous cystadenocarcinoma(323;0.00107)|GBM - Glioblastoma multiforme(294;0.0137)		CCATAGCTCTCTGGAGCTGCA	0.453000													21	73					0	0	1	0	0
OTOP3	347741	broad.mit.edu	37	17	72942938	72942938	+	Missense_Mutation	SNP	G	G	T			TCGA-XF-A8HH-01A-11D-A38G-08	TCGA-XF-A8HH-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f221f317-1da7-437b-9810-d18cc320e339	77ece96f-b1b7-413e-af73-03c11a8f5e91	g.chr17:72942938G>T	ENST00000328801.4	+	6	988	c.988G>T	c.(988-990)Gca>Tca	p.A330S		NM_178233.1	NP_839947.1	Q7RTS5	OTOP3_HUMAN	otopetrin 3	330						integral to membrane|intracellular	zinc ion binding			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(5)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	23	all_lung(278;0.151)|Lung NSC(278;0.185)					CCCTGCCACCGCACCCTTCCA	0.637000													63	105					1.3268e-25	1.41918e-25	1	1	0
GLTP	51228	broad.mit.edu	37	12	110318125	110318125	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-A8HH-01A-11D-A38G-08	TCGA-XF-A8HH-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f221f317-1da7-437b-9810-d18cc320e339	77ece96f-b1b7-413e-af73-03c11a8f5e91	g.chr12:110318125C>T	ENST00000318348.4	-	1	168	c.55G>A	c.(55-57)Gag>Aag	p.E19K	GLTP_ENST00000544393.1_Missense_Mutation_p.E19K	NM_016433.3	NP_057517.1	Q9NZD2	GLTP_HUMAN	glycolipid transfer protein	19						cytoplasm	glycolipid binding|glycolipid transporter activity			endometrium(1)|kidney(1)|lung(1)|upper_aerodigestive_tract(1)	4		Lung NSC(355;2.38e-06)|Breast(359;0.00354)|Myeloproliferative disorder(1001;0.0122)		BRCA - Breast invasive adenocarcinoma(302;0.0025)		GGCCCGGTCTCGATCTGCTTG	0.731000													4	17					0	0	1	0	0
PLXND1	23129	broad.mit.edu	37	3	129281952	129281952	+	Missense_Mutation	SNP	G	G	C	rs150232906	byFrequency	TCGA-XF-A8HH-01A-11D-A38G-08	TCGA-XF-A8HH-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f221f317-1da7-437b-9810-d18cc320e339	77ece96f-b1b7-413e-af73-03c11a8f5e91	g.chr3:129281952G>C	ENST00000393239.1	-	26	4831	c.4653C>G	c.(4651-4653)atC>atG	p.I1551M	PLXND1_ENST00000324093.4_Missense_Mutation_p.I1551M			Q9Y4D7	PLXD1_HUMAN	plexin D1	1551					axon guidance	integral to membrane|intracellular|plasma membrane			PLXND1/TMCC1(4)	NS(1)|breast(1)|endometrium(4)|kidney(5)|large_intestine(17)|lung(28)|prostate(10)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	72						GCTTGGCCTCGATGTTCTCCC	0.637000													6	33					0	0	1	0	0
TET1	80312	broad.mit.edu	37	10	70405515	70405515	+	Nonsense_Mutation	SNP	C	C	G			TCGA-XF-A8HH-01A-11D-A38G-08	TCGA-XF-A8HH-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f221f317-1da7-437b-9810-d18cc320e339	77ece96f-b1b7-413e-af73-03c11a8f5e91	g.chr10:70405515C>G	ENST00000373644.4	+	4	3238	c.3029C>G	c.(3028-3030)tCa>tGa	p.S1010*		NM_030625.2	NP_085128.2	Q8NFU7	TET1_HUMAN	tet methylcytosine dioxygenase 1	1010					DNA demethylation|inner cell mass cell differentiation|negative regulation of methylation-dependent chromatin silencing|stem cell maintenance		iron ion binding|methylcytosine dioxygenase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|structure-specific DNA binding|zinc ion binding			breast(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(2)|ovary(5)|prostate(1)|upper_aerodigestive_tract(2)	21						ATACCAAAATCAAATTCATCC	0.328000													13	47					0	0	1	0	0
SNX6	58533	broad.mit.edu	37	14	35062350	35062350	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-A8HH-01A-11D-A38G-08	TCGA-XF-A8HH-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f221f317-1da7-437b-9810-d18cc320e339	77ece96f-b1b7-413e-af73-03c11a8f5e91	g.chr14:35062350C>G	ENST00000396526.3	-	7	767	c.271G>C	c.(271-273)Gat>Cat	p.D91H	SNX6_ENST00000362031.4_Missense_Mutation_p.D219H|SNX6_ENST00000355110.5_Missense_Mutation_p.D95H|SNX6_ENST00000396534.3_Missense_Mutation_p.D91H			Q9UNH7	SNX6_HUMAN	sorting nexin 6	207	PX.				cell communication|intracellular protein transport|negative regulation of epidermal growth factor receptor activity|negative regulation of transcription, DNA-dependent|negative regulation of transforming growth factor beta receptor signaling pathway|retrograde transport, endosome to Golgi	cytoplasmic vesicle membrane|early endosome membrane|nucleus	phosphatidylinositol binding|protein homodimerization activity			endometrium(4)|lung(1)|ovary(1)	6	Breast(36;0.0473)|Hepatocellular(127;0.158)		LUAD - Lung adenocarcinoma(48;0.00169)|Lung(238;0.00199)|Epithelial(34;0.187)	GBM - Glioblastoma multiforme(112;0.0245)		AAGAAATCATCTACATCCTAT	0.284000													23	49					0	0	1	0	0
MSH4	4438	broad.mit.edu	37	1	76378435	76378435	+	Missense_Mutation	SNP	G	G	T			TCGA-XF-A8HH-01A-11D-A38G-08	TCGA-XF-A8HH-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f221f317-1da7-437b-9810-d18cc320e339	77ece96f-b1b7-413e-af73-03c11a8f5e91	g.chr1:76378435G>T	ENST00000263187.3	+	20	2778	c.2674G>T	c.(2674-2676)Gcc>Tcc	p.A892S		NM_002440.3	NP_002431.2	O15457	MSH4_HUMAN	mutS homolog 4	892					chiasma assembly|homologous chromosome segregation|mismatch repair|reciprocal meiotic recombination	synaptonemal complex	ATP binding|DNA-dependent ATPase activity|mismatched DNA binding			breast(1)|endometrium(2)|kidney(4)|large_intestine(9)|lung(26)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	47						GTACCATCTAGCCACTAGGCT	0.353000								Mismatch excision repair (MMR)					7	20					0.0381472	0.0386041	1	1	0
ZNF236	7776	broad.mit.edu	37	18	74672699	74672699	+	Silent	SNP	G	G	A			TCGA-XF-A8HH-01A-11D-A38G-08	TCGA-XF-A8HH-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f221f317-1da7-437b-9810-d18cc320e339	77ece96f-b1b7-413e-af73-03c11a8f5e91	g.chr18:74672699G>A	ENST00000253159.8	+	30	5499	c.5301G>A	c.(5299-5301)gtG>gtA	p.V1767V	ZNF236_ENST00000320610.9_Silent_p.V1769V	NM_007345.3	NP_031371.3	Q9UL36	ZN236_HUMAN	zinc finger protein 236	1767					cellular response to glucose stimulus	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(43)|ovary(7)|pancreas(1)|prostate(6)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	94		Prostate(75;0.0405)|Esophageal squamous(42;0.129)|Melanoma(33;0.132)		OV - Ovarian serous cystadenocarcinoma(15;4.36e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0686)		CGCTGCAGGTGCACATGAAGA	0.547000													8	65					0	0	1	0	0
CDH12	1010	broad.mit.edu	37	5	21842319	21842319	+	Silent	SNP	G	G	A			TCGA-XF-A8HH-01A-11D-A38G-08	TCGA-XF-A8HH-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f221f317-1da7-437b-9810-d18cc320e339	77ece96f-b1b7-413e-af73-03c11a8f5e91	g.chr5:21842319G>A	ENST00000382254.1	-	8	1851	c.765C>T	c.(763-765)gtC>gtT	p.V255V	CDH12_ENST00000504376.2_Silent_p.V255V|CDH12_ENST00000522262.1_Silent_p.V215V|CDH12_ENST00000521384.1_5'UTR	NM_004061.3	NP_004052.2	P55289	CAD12_HUMAN	cadherin 12, type 2 (N-cadherin 2)	255	Cadherin 2.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(2)|breast(2)|cervix(1)|endometrium(6)|kidney(4)|large_intestine(19)|lung(75)|ovary(2)|prostate(3)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	120						GAGTGATGTTGACTATTGTTG	0.408000										HNSCC(59;0.17)			21	59					0	0	1	0	0
LINC01317	104355287	broad.mit.edu	37	2	33952672	33952672	+	RNA	SNP	G	G	A			TCGA-XF-A8HH-01A-11D-A38G-08	TCGA-XF-A8HH-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f221f317-1da7-437b-9810-d18cc320e339	77ece96f-b1b7-413e-af73-03c11a8f5e91	g.chr2:33952672G>A	ENST00000366209.2	+	0	68				MYADML_ENST00000474610.1_RNA																							TGGCGTGGTCGCGGGAACGGC	0.642000													11	22					0	0	1	0	0
KLF17	128209	broad.mit.edu	37	1	44595607	44595607	+	Missense_Mutation	SNP	A	A	G			TCGA-XF-A8HH-01A-11D-A38G-08	TCGA-XF-A8HH-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f221f317-1da7-437b-9810-d18cc320e339	77ece96f-b1b7-413e-af73-03c11a8f5e91	g.chr1:44595607A>G	ENST00000372299.3	+	2	722	c.664A>G	c.(664-666)Atg>Gtg	p.M222V	KLF17_ENST00000476802.1_Intron	NM_173484.3	NP_775755.3	Q5JT82	KLF17_HUMAN	Kruppel-like factor 17	222					regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			NS(1)|breast(2)|central_nervous_system(1)|large_intestine(1)|lung(6)|ovary(3)|prostate(1)|skin(2)|stomach(1)	18	Acute lymphoblastic leukemia(166;0.155)					TGACCTTGGGATGCCCCCAGC	0.577000													9	47					0	0	1	0	0
FARP2	9855	broad.mit.edu	37	2	242371150	242371150	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-A8HH-01A-11D-A38G-08	TCGA-XF-A8HH-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f221f317-1da7-437b-9810-d18cc320e339	77ece96f-b1b7-413e-af73-03c11a8f5e91	g.chr2:242371150G>C	ENST00000264042.3	+	9	998	c.828G>C	c.(826-828)aaG>aaC	p.K276N	FARP2_ENST00000373287.4_Missense_Mutation_p.K276N|FARP2_ENST00000545004.1_Missense_Mutation_p.K276N	NM_014808.2	NP_055623.1	O94887	FARP2_HUMAN	FERM, RhoGEF and pleckstrin domain protein 2	276	FERM.				axon guidance|neuron remodeling|Rac protein signal transduction|regulation of Rho protein signal transduction	cytoskeleton|cytosol|extrinsic to membrane	cytoskeletal protein binding|Rho guanyl-nucleotide exchange factor activity	p.K276K(1)		breast(1)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(8)|lung(18)|ovary(2)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	43		all_cancers(19;4.88e-34)|all_epithelial(40;4.81e-14)|Breast(86;0.000141)|Renal(207;0.0143)|all_lung(227;0.0344)|Lung NSC(271;0.0886)|Ovarian(221;0.0905)|Esophageal squamous(248;0.131)|all_hematologic(139;0.182)|Melanoma(123;0.238)		Epithelial(32;1.81e-33)|all cancers(36;1.61e-30)|OV - Ovarian serous cystadenocarcinoma(60;6.83e-15)|Kidney(56;1.19e-08)|KIRC - Kidney renal clear cell carcinoma(57;8.98e-08)|BRCA - Breast invasive adenocarcinoma(100;1.49e-06)|Lung(119;0.000152)|LUSC - Lung squamous cell carcinoma(224;0.00125)|Colorectal(34;0.0199)|COAD - Colon adenocarcinoma(134;0.121)		TAAGCTTCAAGAGGAAAAGAT	0.299000													36	47					0	0	1	0	0
PAPPA	5069	broad.mit.edu	37	9	119097189	119097189	+	Silent	SNP	C	C	G			TCGA-XF-A8HH-01A-11D-A38G-08	TCGA-XF-A8HH-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f221f317-1da7-437b-9810-d18cc320e339	77ece96f-b1b7-413e-af73-03c11a8f5e91	g.chr9:119097189C>G	ENST00000328252.3	+	13	3816	c.3447C>G	c.(3445-3447)gtC>gtG	p.V1149V	PAPPA_ENST00000534838.1_Silent_p.V187V	NM_002581.3	NP_002572.2	Q13219	PAPP1_HUMAN	pregnancy-associated plasma protein A, pappalysin 1	1149					cell differentiation|female pregnancy	cytoplasm|extracellular region|membrane	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(4)|endometrium(9)|kidney(2)|large_intestine(23)|lung(33)|ovary(4)|pancreas(2)|prostate(5)|skin(7)|stomach(1)|upper_aerodigestive_tract(6)|urinary_tract(1)	98						TCCCTGTGGTCCATGACCTCA	0.622000													7	29					0	0	1	0	0
PCDH1	5097	broad.mit.edu	37	5	141236880	141236880	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-A8HH-01A-11D-A38G-08	TCGA-XF-A8HH-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f221f317-1da7-437b-9810-d18cc320e339	77ece96f-b1b7-413e-af73-03c11a8f5e91	g.chr5:141236880C>T	ENST00000287008.3	-	4	3403	c.3256G>A	c.(3256-3258)Gag>Aag	p.E1086K	PCDH1_ENST00000503492.1_Missense_Mutation_p.E354K	NM_032420.2	NP_115796.2	Q08174	PCDH1_HUMAN	protocadherin 1	0					cell-cell signaling|homophilic cell adhesion|nervous system development	cell-cell junction|integral to plasma membrane	calcium ion binding			breast(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(4)|lung(20)|ovary(5)|skin(3)|upper_aerodigestive_tract(1)	51		Lung NSC(810;0.027)|all_lung(500;0.0321)|all_hematologic(541;0.0433)|Prostate(461;0.0453)|Breast(839;0.128)|Lung SC(612;0.238)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)	GBM - Glioblastoma multiforme(465;1.06e-05)		TAGTGATCCTCAGGCAGGGCC	0.617000													10	19					0	0	1	0	0
PREPL	9581	broad.mit.edu	37	2	44571025	44571025	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-A8HH-01A-11D-A38G-08	TCGA-XF-A8HH-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f221f317-1da7-437b-9810-d18cc320e339	77ece96f-b1b7-413e-af73-03c11a8f5e91	g.chr2:44571025C>T	ENST00000541738.1	-	4	594	c.208G>A	c.(208-210)Gat>Aat	p.D70N	PREPL_ENST00000409957.1_Missense_Mutation_p.D70N|PREPL_ENST00000409272.1_Missense_Mutation_p.D159N|PREPL_ENST00000378520.3_Missense_Mutation_p.D159N|PREPL_ENST00000378511.3_Missense_Mutation_p.D159N|PREPL_ENST00000540817.1_5'UTR|PREPL_ENST00000409936.1_Missense_Mutation_p.D159N|PREPL_ENST00000410081.1_Missense_Mutation_p.D159N|PREPL_ENST00000409411.1_Missense_Mutation_p.D70N|PREPL_ENST00000260648.6_Missense_Mutation_p.D159N	NM_001171617.1	NP_001165088.1	Q4J6C6	PPCEL_HUMAN	prolyl endopeptidase-like	159					proteolysis	cytosol	serine-type endopeptidase activity			breast(1)|endometrium(4)|kidney(2)|large_intestine(3)|lung(19)|ovary(1)|prostate(1)|skin(2)	33		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)				CTGATACAATCAATGAAGGGC	0.343000													31	76					0	0	1	0	0
QRICH2	84074	broad.mit.edu	37	17	74273247	74273247	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-A8HH-01A-11D-A38G-08	TCGA-XF-A8HH-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f221f317-1da7-437b-9810-d18cc320e339	77ece96f-b1b7-413e-af73-03c11a8f5e91	g.chr17:74273247C>T	ENST00000262765.5	-	16	4943	c.4764G>A	c.(4762-4764)atG>atA	p.M1588I		NM_032134.1	NP_115510.1	Q9H0J4	QRIC2_HUMAN	glutamine rich 2	1588							protein binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(6)|lung(17)|ovary(4)|pancreas(2)|prostate(3)|skin(2)|stomach(4)	62						CCCTGACCTTCATGGCAATCT	0.627000													19	34					0	0	1	0	0
KAT7	11143	broad.mit.edu	37	17	47895248	47895248	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-A8HH-01A-11D-A38G-08	TCGA-XF-A8HH-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f221f317-1da7-437b-9810-d18cc320e339	77ece96f-b1b7-413e-af73-03c11a8f5e91	g.chr17:47895248C>T	ENST00000503935.2	+	9	1598	c.562C>T	c.(562-564)Cgc>Tgc	p.R188C	KAT7_ENST00000513980.1_Intron|KAT7_ENST00000509773.1_Missense_Mutation_p.R234C|KAT7_ENST00000454930.2_Missense_Mutation_p.R205C|KAT7_ENST00000424009.2_Missense_Mutation_p.R314C|KAT7_ENST00000259021.4_Missense_Mutation_p.R344C|KAT7_ENST00000435742.2_Missense_Mutation_p.R158C|KAT7_ENST00000510819.1_Missense_Mutation_p.R175C			O95251	MYST2_HUMAN	K(lysine) acetyltransferase 7	344					DNA replication|histone H3 acetylation|histone H4-K12 acetylation|histone H4-K5 acetylation|histone H4-K8 acetylation	histone acetyltransferase complex	histone acetyltransferase activity|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding										TGCTTTTGGCCGCTATGAGCT	0.403000													19	43					0	0	1	0	0
AGO3	192669	broad.mit.edu	37	1	36397036	36397036	+	Silent	SNP	C	C	T			TCGA-XF-A8HH-01A-11D-A38G-08	TCGA-XF-A8HH-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f221f317-1da7-437b-9810-d18cc320e339	77ece96f-b1b7-413e-af73-03c11a8f5e91	g.chr1:36397036C>T	ENST00000373191.4	+	1	358	c.9C>T	c.(7-9)atC>atT	p.I3I	AGO3_ENST00000246314.6_5'UTR|AGO3_ENST00000324350.5_Silent_p.I3I|AGO3_ENST00000397828.2_Silent_p.I3I	NM_024852.3	NP_079128.2			argonaute RISC catalytic component 3																		GAATGGAAATCGGCTCCGCAG	0.701000													4	7					0	0	1	0	0
PRELID2	153768	broad.mit.edu	37	5	145176089	145176089	+	Silent	SNP	G	G	A			TCGA-XF-A8HH-01A-11D-A38G-08	TCGA-XF-A8HH-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f221f317-1da7-437b-9810-d18cc320e339	77ece96f-b1b7-413e-af73-03c11a8f5e91	g.chr5:145176089G>A	ENST00000334744.4	-	6	478	c.426C>T	c.(424-426)ggC>ggT	p.G142G	PRELID2_ENST00000505416.1_Silent_p.G130G|PRELID2_ENST00000511435.1_Silent_p.G130G|PRELID2_ENST00000510594.1_5'UTR|PRELID2_ENST00000358004.2_Silent_p.G130G|PRELID2_ENST00000394450.2_Silent_p.G101G	NM_182960.2	NP_892005.1	Q8N945	PRLD2_HUMAN	PRELI domain containing 2	142	PRELI/MSF1.									endometrium(2)|large_intestine(1)|lung(2)|prostate(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			TTGAAATCCTGCCTCTTTGAA	0.393000													20	56					0	0	1	0	0
NLRP13	126204	broad.mit.edu	37	19	56407431	56407431	+	Silent	SNP	G	G	C			TCGA-XF-A8HH-01A-11D-A38G-08	TCGA-XF-A8HH-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f221f317-1da7-437b-9810-d18cc320e339	77ece96f-b1b7-413e-af73-03c11a8f5e91	g.chr19:56407431G>C	ENST00000588751.1	-	11	3036	c.3012C>G	c.(3010-3012)ctC>ctG	p.L1004L	NLRP13_ENST00000342929.3_Silent_p.L1004L			Q86W25	NAL13_HUMAN	NLR family, pyrin domain containing 13	1004							ATP binding			NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(13)|lung(58)|ovary(4)|pancreas(2)|prostate(2)|skin(13)|stomach(2)|urinary_tract(1)	109		Colorectal(82;3.48e-05)|Ovarian(87;0.0481)|Renal(1328;0.218)		GBM - Glioblastoma multiforme(193;0.0642)		TACTGCTGCTGAGAACAGAGA	0.473000													26	54					0	0	1	0	0
ABCA5	23461	broad.mit.edu	37	17	67282434	67282434	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-A8HH-01A-11D-A38G-08	TCGA-XF-A8HH-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f221f317-1da7-437b-9810-d18cc320e339	77ece96f-b1b7-413e-af73-03c11a8f5e91	g.chr17:67282434G>A	ENST00000392676.3	-	16	2124	c.2060C>T	c.(2059-2061)tCa>tTa	p.S687L	ABCA5_ENST00000392677.2_Missense_Mutation_p.S687L|ABCA5_ENST00000588877.1_Missense_Mutation_p.S687L			Q8WWZ7	ABCA5_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 5	687	ABC transporter 1.				cholesterol efflux|high-density lipoprotein particle remodeling|negative regulation of macrophage derived foam cell differentiation	Golgi membrane|integral to membrane|late endosome membrane|lysosomal membrane	ATP binding|ATPase activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(18)|lung(19)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(1)	54	Breast(10;3.72e-11)					CATTCCTTGTGATATCACAGC	0.328000													6	41					0	0	1	0	0
DNAH8	1769	broad.mit.edu	37	6	38841115	38841115	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-A8HH-01A-11D-A38G-08	TCGA-XF-A8HH-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f221f317-1da7-437b-9810-d18cc320e339	77ece96f-b1b7-413e-af73-03c11a8f5e91	g.chr6:38841115C>T	ENST00000359357.3	+	50	7186	c.6932C>T	c.(6931-6933)cCc>cTc	p.P2311L	DNAH8_ENST00000441566.1_Missense_Mutation_p.P2275L|DNAH8_ENST00000449981.2_Missense_Mutation_p.P2528L					dynein, axonemal, heavy chain 8											NS(7)|breast(9)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(16)|large_intestine(44)|liver(4)|lung(101)|ovary(7)|pancreas(2)|prostate(8)|skin(28)|stomach(4)|upper_aerodigestive_tract(6)|urinary_tract(4)	260						AATCTCAATCCCAAAATGCAG	0.353000													10	68					0	0	1	0	0
RDH11	51109	broad.mit.edu	37	14	68157903	68157903	+	Silent	SNP	C	C	T	rs17853736		TCGA-XF-A8HH-01A-11D-A38G-08	TCGA-XF-A8HH-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f221f317-1da7-437b-9810-d18cc320e339	77ece96f-b1b7-413e-af73-03c11a8f5e91	g.chr14:68157903C>T	ENST00000381346.4	-	4	518	c.408G>A	c.(406-408)tcG>tcA	p.S136S	RDH11_ENST00000553384.1_Silent_p.S123S|RDH11_ENST00000428130.2_Silent_p.S136S	NM_001252650.1|NM_016026.3	NP_001239579.1|NP_057110.3	Q8TC12	RDH11_HUMAN	retinol dehydrogenase 11 (all-trans/9-cis/11-cis)	136					retinol metabolic process|steroid metabolic process	endoplasmic reticulum membrane|integral to membrane	binding|NADP-retinol dehydrogenase activity|retinol dehydrogenase activity			breast(2)|endometrium(1)|kidney(3)|large_intestine(2)|lung(3)|ovary(1)	12				all cancers(60;0.00047)|OV - Ovarian serous cystadenocarcinoma(108;0.00206)|BRCA - Breast invasive adenocarcinoma(234;0.00924)	Vitamin A(DB00162)	CTGCTGTCTTCGAGTACGGAC	0.483000													49	104					0	0	1	0	0
MYO18A	399687	broad.mit.edu	37	17	27414050	27414050	+	Silent	SNP	C	C	T			TCGA-XF-A8HH-01A-11D-A38G-08	TCGA-XF-A8HH-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f221f317-1da7-437b-9810-d18cc320e339	77ece96f-b1b7-413e-af73-03c11a8f5e91	g.chr17:27414050C>T	ENST00000527372.1	-	38	5796	c.5616G>A	c.(5614-5616)caG>caA	p.Q1872Q	MYO18A_ENST00000354329.4_Silent_p.Q1872Q|MYO18A_ENST00000529578.1_5'UTR|TIAF1_ENST00000408971.2_5'UTR|MYO18A_ENST00000533112.1_Silent_p.Q1835Q|MYO18A_ENST00000531253.1_Silent_p.Q1872Q	NM_078471.3	NP_510880.2	Q92614	MY18A_HUMAN	myosin XVIIIA	1872					anti-apoptosis|DNA metabolic process	ER-Golgi intermediate compartment|myosin complex	ATP binding|DNA binding|DNA-dependent ATPase activity|identical protein binding|motor activity			NS(1)|cervix(1)|endometrium(6)|kidney(6)|lung(20)|urinary_tract(2)	36			Epithelial(11;4.97e-05)|BRCA - Breast invasive adenocarcinoma(11;0.000221)|all cancers(11;0.000234)|Colorectal(6;0.0102)|COAD - Colon adenocarcinoma(6;0.031)			GCCGCTTGTTCTGTTCCTTCT	0.592000													10	75					0	0	1	0	0
C11orf1	64776	broad.mit.edu	37	11	111753253	111753253	+	Silent	SNP	G	G	C			TCGA-XF-A8HH-01A-11D-A38G-08	TCGA-XF-A8HH-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f221f317-1da7-437b-9810-d18cc320e339	77ece96f-b1b7-413e-af73-03c11a8f5e91	g.chr11:111753253G>C	ENST00000260276.3	+	2	544	c.207G>C	c.(205-207)ctG>ctC	p.L69L	C11orf1_ENST00000530214.1_Silent_p.L69L|C11orf1_ENST00000528125.1_Silent_p.L23L|C11orf1_ENST00000529270.1_Silent_p.L109L	NM_022761.2	NP_073598.1	Q9H5F2	CK001_HUMAN	chromosome 11 open reading frame 1	69						nucleus				kidney(2)|lung(3)	5		all_cancers(61;1.26e-15)|all_epithelial(67;9.52e-10)|Melanoma(852;1.91e-06)|all_hematologic(158;0.000405)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0112)|Medulloblastoma(222;0.0228)|all_neural(223;0.0281)		all cancers(92;6.28e-09)|Epithelial(105;4.11e-08)|OV - Ovarian serous cystadenocarcinoma(223;1.52e-07)|BRCA - Breast invasive adenocarcinoma(274;1.1e-06)		ACCGTACCCTGATGGGCAACT	0.438000													12	21					0	0	1	0	0
ZNF208	7757	broad.mit.edu	37	19	22154862	22154862	+	Missense_Mutation	SNP	T	T	C			TCGA-XF-A8HH-01A-11D-A38G-08	TCGA-XF-A8HH-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f221f317-1da7-437b-9810-d18cc320e339	77ece96f-b1b7-413e-af73-03c11a8f5e91	g.chr19:22154862T>C	ENST00000397126.4	-	4	3122	c.2974A>G	c.(2974-2976)Aag>Gag	p.K992E	ZNF208_ENST00000599916.1_Intron|ZNF208_ENST00000601773.1_Intron	NM_007153.3	NP_009084.2			zinc finger protein 208											breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(18)|liver(1)|lung(71)|ovary(6)|prostate(3)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	113		all_lung(12;0.0961)|Lung NSC(12;0.103)				TGAATTACCTTATGTTTAGTA	0.343000													3	71					0	0	1	0	0
FAM111A	63901	broad.mit.edu	37	11	58920671	58920671	+	Silent	SNP	G	G	A			TCGA-XF-A8HH-01A-11D-A38G-08	TCGA-XF-A8HH-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f221f317-1da7-437b-9810-d18cc320e339	77ece96f-b1b7-413e-af73-03c11a8f5e91	g.chr11:58920671G>A	ENST00000528737.1	+	5	4348	c.1530G>A	c.(1528-1530)gaG>gaA	p.E510E	FAM111A_ENST00000531147.1_Silent_p.E510E|FAM111A_ENST00000361723.3_Silent_p.E510E|FAM111A_ENST00000420244.1_Silent_p.E510E|FAM111A_ENST00000533703.1_Silent_p.E510E			Q96PZ2	F111A_HUMAN	family with sequence similarity 111, member A	510					proteolysis		serine-type endopeptidase activity			breast(2)|endometrium(2)|kidney(1)|large_intestine(5)|lung(5)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	22		all_epithelial(135;0.139)				AAAGTCCAGAGTATGTCCATA	0.423000													23	75					0	0	1	0	0
NARG2	79664	broad.mit.edu	37	15	60741617	60741617	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-A8HH-01A-11D-A38G-08	TCGA-XF-A8HH-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f221f317-1da7-437b-9810-d18cc320e339	77ece96f-b1b7-413e-af73-03c11a8f5e91	g.chr15:60741617C>G	ENST00000261520.4	-	10	1783	c.1549G>C	c.(1549-1551)Gaa>Caa	p.E517Q	NARG2_ENST00000439632.1_Missense_Mutation_p.E380Q	NM_024611.4	NP_078887.2	Q659A1	NARG2_HUMAN	NMDA receptor regulated 2	517						nucleus				breast(1)|central_nervous_system(1)|endometrium(7)|kidney(3)|large_intestine(2)|lung(10)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)	32						TGAGAATTTTCTAACTGTAAG	0.313000													24	66					0	0	1	0	0
MED14	9282	broad.mit.edu	37	X	40534580	40534580	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-A8HH-01A-11D-A38G-08	TCGA-XF-A8HH-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f221f317-1da7-437b-9810-d18cc320e339	77ece96f-b1b7-413e-af73-03c11a8f5e91	g.chrX:40534580C>T	ENST00000324817.1	-	22	3032	c.2914G>A	c.(2914-2916)Gat>Aat	p.D972N	MED14_ENST00000496531.2_5'UTR	NM_004229.3	NP_004220.2	O60244	MED14_HUMAN	mediator complex subunit 14	972					androgen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding	p.D972N(1)		NS(2)|breast(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(7)|lung(8)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	39						CTTCGAGCATCCTGATTGCTG	0.363000													9	34					0	0	1	0	0
CEACAM8	1088	broad.mit.edu	37	19	43087450	43087450	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-A8HH-01A-11D-A38G-08	TCGA-XF-A8HH-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f221f317-1da7-437b-9810-d18cc320e339	77ece96f-b1b7-413e-af73-03c11a8f5e91	g.chr19:43087450C>G	ENST00000244336.5	-	5	1099	c.998G>C	c.(997-999)aGa>aCa	p.R333T	LIPE-AS1_ENST00000594624.2_RNA|CEACAM8_ENST00000599005.1_Missense_Mutation_p.R35T|LIPE-AS1_ENST00000594688.1_RNA	NM_001816.3	NP_001807.2	P31997	CEAM8_HUMAN	carcinoembryonic antigen-related cell adhesion molecule 8	333					immune response	anchored to membrane|extracellular space|integral to plasma membrane				endometrium(1)|large_intestine(5)|lung(5)|ovary(1)|pancreas(1)|prostate(2)|skin(1)	16		Prostate(69;0.00899)				GACAGTGGCTCTAGCTGAGAG	0.463000													13	43					0	0	1	0	0
ATP12A	479	broad.mit.edu	37	13	25274889	25274889	+	Silent	SNP	C	C	T			TCGA-XF-A8HH-01A-11D-A38G-08	TCGA-XF-A8HH-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f221f317-1da7-437b-9810-d18cc320e339	77ece96f-b1b7-413e-af73-03c11a8f5e91	g.chr13:25274889C>T	ENST00000218548.6	+	13	2061	c.1728C>T	c.(1726-1728)ttC>ttT	p.F576F	ATP12A_ENST00000381946.3_Silent_p.F570F	NM_001185085.1|NM_001676.5	NP_001172014.1|NP_001667.4	P54707	AT12A_HUMAN	ATPase, H+/K+ transporting, nongastric, alpha polypeptide	570					ATP biosynthetic process	hydrogen:potassium-exchanging ATPase complex	ATP binding|hydrogen:potassium-exchanging ATPase activity|metal ion binding			breast(6)|central_nervous_system(4)|endometrium(3)|kidney(5)|large_intestine(23)|lung(23)|ovary(2)|pancreas(1)|prostate(2)|skin(5)	74		Lung SC(185;0.0225)|Breast(139;0.077)		all cancers(112;0.0307)|Epithelial(112;0.086)|OV - Ovarian serous cystadenocarcinoma(117;0.228)	Esomeprazole(DB00736)|Pantoprazole(DB00213)	TTACAGGTTTCTGTCATCTCT	0.423000													18	28					0	0	1	0	0
LOXL2	4017	broad.mit.edu	37	8	23160801	23160801	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-A8HH-01A-11D-A38G-08	TCGA-XF-A8HH-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f221f317-1da7-437b-9810-d18cc320e339	77ece96f-b1b7-413e-af73-03c11a8f5e91	g.chr8:23160801C>G	ENST00000389131.3	-	11	2359	c.1990G>C	c.(1990-1992)Gaa>Caa	p.E664Q		NM_002318.2	NP_002309.1	Q9Y4K0	LOXL2_HUMAN	lysyl oxidase-like 2	664	Lysyl-oxidase like.				aging|cell adhesion|protein modification process	extracellular space|membrane	copper ion binding|electron carrier activity|oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor|scavenger receptor activity			breast(2)|endometrium(4)|kidney(3)|large_intestine(12)|lung(5)|ovary(2)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	35		Prostate(55;0.0453)|Breast(100;0.143)		Colorectal(74;0.0288)|COAD - Colon adenocarcinoma(73;0.096)		ATACCTCCTTCACATTCTGTG	0.602000													16	28					0	0	1	0	0
IFT88	8100	broad.mit.edu	37	13	21265282	21265282	+	Nonsense_Mutation	SNP	G	G	T			TCGA-XF-A8HH-01A-11D-A38G-08	TCGA-XF-A8HH-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f221f317-1da7-437b-9810-d18cc320e339	77ece96f-b1b7-413e-af73-03c11a8f5e91	g.chr13:21265282G>T	ENST00000319980.6	+	28	2797	c.2470G>T	c.(2470-2472)Gaa>Taa	p.E824*	IFT88_ENST00000351808.5_Nonsense_Mutation_p.E815*|IFT88_ENST00000537103.1_Nonsense_Mutation_p.E796*|IFT88_ENST00000382778.4_3'UTR	NM_175605.3	NP_783195.2	Q13099	IFT88_HUMAN	intraflagellar transport 88 homolog (Chlamydomonas)	824					cilium morphogenesis	centriole|intraflagellar transport particle B|microtubule basal body|microtubule-based flagellum	protein binding	p.E824*(1)		breast(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(13)|ovary(1)|prostate(2)|skin(2)|urinary_tract(1)	27		all_cancers(29;5.79e-25)|all_epithelial(30;2.57e-20)|all_lung(29;3.13e-16)|Lung SC(185;0.0262)|Ovarian(182;0.0825)|Hepatocellular(188;0.244)		all cancers(112;0.000667)|Epithelial(112;0.00119)|OV - Ovarian serous cystadenocarcinoma(117;0.0141)|Lung(94;0.0183)|LUSC - Lung squamous cell carcinoma(192;0.0528)		TTTTGCTGATGAAGAATTAGG	0.378000													18	46					3.32936e-07	3.47322e-07	1	1	0
HEATR6	63897	broad.mit.edu	37	17	58134520	58134520	+	Silent	SNP	G	G	T			TCGA-XF-A8HH-01A-11D-A38G-08	TCGA-XF-A8HH-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f221f317-1da7-437b-9810-d18cc320e339	77ece96f-b1b7-413e-af73-03c11a8f5e91	g.chr17:58134520G>T	ENST00000184956.6	-	12	1984	c.1968C>A	c.(1966-1968)ctC>ctA	p.L656L	HEATR6_ENST00000585976.1_Silent_p.L656L	NM_022070.4	NP_071353.4	Q6AI08	HEAT6_HUMAN	HEAT repeat containing 6	656							binding			NS(1)|breast(4)|endometrium(5)|kidney(2)|large_intestine(4)|lung(7)|ovary(2)|pancreas(1)|prostate(4)|skin(10)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	44	all_cancers(5;2.25e-13)|Breast(5;4.84e-25)|all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		BRCA - Breast invasive adenocarcinoma(1;5.93e-19)|Epithelial(12;7.59e-12)|all cancers(12;1.26e-10)			TGGAAATGCAGAGTCGAATGA	0.557000													33	64					1.04352e-10	1.10915e-10	1	1	0
AHNAK2	113146	broad.mit.edu	37	14	105413205	105413205	+	Silent	SNP	G	G	A			TCGA-XF-A8HH-01A-11D-A38G-08	TCGA-XF-A8HH-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f221f317-1da7-437b-9810-d18cc320e339	77ece96f-b1b7-413e-af73-03c11a8f5e91	g.chr14:105413205G>A	ENST00000333244.5	-	7	8702	c.8583C>T	c.(8581-8583)atC>atT	p.I2861I	AHNAK2_ENST00000557457.1_Intron	NM_138420.2	NP_612429.2	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	2861						nucleus				cervix(4)|endometrium(4)|large_intestine(3)|lung(14)|ovary(2)|prostate(2)|skin(1)|stomach(3)	33		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			GCTGAATGCGGATGTCAGTGG	0.632000													8	150					0	0	1	0	0
OR52J3	119679	broad.mit.edu	37	11	5067999	5067999	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-A8HH-01A-11D-A38G-08	TCGA-XF-A8HH-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f221f317-1da7-437b-9810-d18cc320e339	77ece96f-b1b7-413e-af73-03c11a8f5e91	g.chr11:5067999C>T	ENST00000380370.1	+	1	244	c.244C>T	c.(244-246)Cgc>Tgc	p.R82C		NM_001001916.2	NP_001001916.2	Q8NH60	O52J3_HUMAN	olfactory receptor, family 52, subfamily J, member 3	82					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.R82C(1)		NS(1)|endometrium(1)|kidney(6)|large_intestine(6)|lung(19)|ovary(1)|skin(2)	36		Medulloblastoma(188;0.00131)|all_neural(188;0.0189)|Breast(177;0.0204)		Epithelial(150;9.29e-10)|BRCA - Breast invasive adenocarcinoma(625;0.135)|LUSC - Lung squamous cell carcinoma(625;0.19)		CTCTGTGCCTCGCATGCTGGG	0.498000													16	57					0	0	1	0	0
ARID2	196528	broad.mit.edu	37	12	46298733	46298733	+	Nonsense_Mutation	SNP	G	G	T			TCGA-XF-A8HH-01A-11D-A38G-08	TCGA-XF-A8HH-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f221f317-1da7-437b-9810-d18cc320e339	77ece96f-b1b7-413e-af73-03c11a8f5e91	g.chr12:46298733G>T	ENST00000334344.6	+	21	5552	c.5380G>T	c.(5380-5382)Gaa>Taa	p.E1794*	ARID2_ENST00000479608.1_3'UTR|ARID2_ENST00000457135.1_3'UTR|ARID2_ENST00000444670.1_Nonsense_Mutation_p.E1404*	NM_152641.2	NP_689854.2	Q68CP9	ARID2_HUMAN	AT rich interactive domain 2 (ARID, RFX-like)	1794					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(7)|central_nervous_system(3)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(21)|liver(20)|lung(34)|ovary(7)|pancreas(1)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	116	Lung SC(27;0.192)|Renal(347;0.236)	Lung NSC(34;0.106)|all_lung(34;0.22)	OV - Ovarian serous cystadenocarcinoma(5;0.00691)	GBM - Glioblastoma multiforme(48;0.0153)		AAAGAGACATGAAAATAACTT	0.348000			"""N, S, F"""		hepatocellular carcinoma								6	25					0.248553	0.248553	1	1	0
SLAIN1	122060	broad.mit.edu	37	13	78335205	78335205	+	Missense_Mutation	SNP	A	A	G			TCGA-XF-A8HH-01A-11D-A38G-08	TCGA-XF-A8HH-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f221f317-1da7-437b-9810-d18cc320e339	77ece96f-b1b7-413e-af73-03c11a8f5e91	g.chr13:78335205A>G	ENST00000466548.1	+	7	1617	c.1591A>G	c.(1591-1593)Agt>Ggt	p.S531G	SLAIN1_ENST00000418532.1_Missense_Mutation_p.S312G|SLAIN1_ENST00000351546.3_Missense_Mutation_p.S268G|SLAIN1_ENST00000488699.1_Missense_Mutation_p.S389G|SLAIN1_ENST00000314070.5_Missense_Mutation_p.S154G|SLAIN1_ENST00000267219.8_Missense_Mutation_p.S312G|SLAIN1_ENST00000358679.3_Missense_Mutation_p.S268G	NM_001242868.1	NP_001229797.1	Q8ND83	SLAI1_HUMAN	SLAIN motif family, member 1	531										breast(1)|endometrium(3)|large_intestine(1)|lung(6)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	14		Acute lymphoblastic leukemia(28;0.0279)|Breast(118;0.037)		GBM - Glioblastoma multiforme(99;0.0853)		AATAAATGGGAGTAACCTGCC	0.463000													19	30					0	0	1	0	0
KIAA1217	56243	broad.mit.edu	37	10	24820855	24820855	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-A8HH-01A-11D-A38G-08	TCGA-XF-A8HH-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f221f317-1da7-437b-9810-d18cc320e339	77ece96f-b1b7-413e-af73-03c11a8f5e91	g.chr10:24820855C>T	ENST00000376451.2	+	10	2488	c.2228C>T	c.(2227-2229)tCg>tTg	p.S743L	KIAA1217_ENST00000376452.3_Missense_Mutation_p.S1024L|KIAA1217_ENST00000458595.1_Missense_Mutation_p.S1025L|KIAA1217_ENST00000376454.3_Missense_Mutation_p.S1060L|KIAA1217_ENST00000396446.1_Missense_Mutation_p.S743L|KIAA1217_ENST00000376462.1_Missense_Mutation_p.S980L|KIAA1217_ENST00000307544.6_Missense_Mutation_p.S743L|KIAA1217_ENST00000396445.1_Missense_Mutation_p.S743L			Q5T5P2	SKT_HUMAN	KIAA1217	1060					embryonic skeletal system development	cytoplasm				breast(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(19)|lung(19)|ovary(5)|prostate(3)|skin(3)|urinary_tract(1)	70						CTGCCAGGATCGGGACTCACC	0.577000													3	21					0	0	1	0	0
DIAPH2	1730	broad.mit.edu	37	X	96684678	96684678	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-A8HH-01A-11D-A38G-08	TCGA-XF-A8HH-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f221f317-1da7-437b-9810-d18cc320e339	77ece96f-b1b7-413e-af73-03c11a8f5e91	g.chrX:96684678C>T	ENST00000324765.8	+	26	3522	c.3175C>T	c.(3175-3177)Ctt>Ttt	p.L1059F	DIAPH2_ENST00000373061.3_Missense_Mutation_p.L1059F|DIAPH2_ENST00000373054.4_Missense_Mutation_p.L1055F|DIAPH2_ENST00000355827.4_Missense_Mutation_p.L1059F|DIAPH2_ENST00000373049.4_Missense_Mutation_p.L1059F			O60879	DIAP2_HUMAN	diaphanous-related formin 2	1059	DAD.				cell differentiation|cytokinesis|multicellular organismal development|oogenesis	cytosol|early endosome|Golgi apparatus|mitochondrion|nucleolus	receptor binding|Rho GTPase binding			breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(13)|lung(15)|ovary(4)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	51						GATGGATAATCTTCTAGAAGC	0.403000													7	27					0	0	1	0	0
NCOR2	9612	broad.mit.edu	37	12	124821405	124821405	+	Silent	SNP	G	G	A			TCGA-XF-A8HH-01A-11D-A38G-08	TCGA-XF-A8HH-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f221f317-1da7-437b-9810-d18cc320e339	77ece96f-b1b7-413e-af73-03c11a8f5e91	g.chr12:124821405G>A	ENST00000356219.3	-	39	6185	c.6030C>T	c.(6028-6030)caC>caT	p.H2010H	NCOR2_ENST00000404621.1_Silent_p.H1993H|NCOR2_ENST00000397355.1_Silent_p.H1994H|NCOR2_ENST00000405201.1_Silent_p.H2003H|NCOR2_ENST00000429285.2_Silent_p.H1993H|NCOR2_ENST00000404121.2_Silent_p.H1564H	NM_006312.5	NP_006303.4	Q9Y618	NCOR2_HUMAN	nuclear receptor corepressor 2	2014					cellular lipid metabolic process|negative regulation of transcription from RNA polymerase II promoter|regulation of cellular ketone metabolic process by negative regulation of transcription from an RNA polymerase II promoter|transcription, DNA-dependent	nuclear body|nucleus|transcriptional repressor complex	DNA binding|histone deacetylase binding|Notch binding|protein N-terminus binding|transcription corepressor activity			breast(5)|central_nervous_system(2)|endometrium(7)|kidney(5)|large_intestine(7)|lung(28)|ovary(3)|pancreas(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	69	all_neural(191;0.0804)|Medulloblastoma(191;0.163)			Epithelial(86;3.99e-05)|OV - Ovarian serous cystadenocarcinoma(86;9.14e-05)|all cancers(50;0.000402)|BRCA - Breast invasive adenocarcinoma(302;0.0764)		CCGGGCTGGCGTGGTGAGGTG	0.677000													3	27					0	0	1	0	0
TRAV17	28666	broad.mit.edu	37	14	22465850	22465850	+	RNA	SNP	A	A	G			TCGA-XF-A8HH-01A-11D-A38G-08	TCGA-XF-A8HH-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f221f317-1da7-437b-9810-d18cc320e339	77ece96f-b1b7-413e-af73-03c11a8f5e91	g.chr14:22465850A>G	ENST00000390445.2	+	0	73																											GGATTCACCCAGTAAAGAGAG	0.468000													3	7					0	0	1	0	0
NUBP1	4682	broad.mit.edu	37	16	10837823	10837823	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-A8HH-01A-11D-A38G-08	TCGA-XF-A8HH-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f221f317-1da7-437b-9810-d18cc320e339	77ece96f-b1b7-413e-af73-03c11a8f5e91	g.chr16:10837823C>T	ENST00000283027.5	+	2	44	c.25C>T	c.(25-27)Cca>Tca	p.P9S	NUBP1_ENST00000433392.2_Missense_Mutation_p.P9S|NUBP1_ENST00000571790.1_3'UTR	NM_002484.2	NP_002475.2	P53384	NUBP1_HUMAN	nucleotide binding protein 1	9					cell growth|cellular iron ion homeostasis|iron-sulfur cluster assembly	cytosol	4 iron, 4 sulfur cluster binding|ATP binding|metal ion binding|nucleoside-triphosphatase activity|protein binding			large_intestine(2)|lung(3)|ovary(1)|skin(4)	10						CGCAGACTGTCCAGGGGCCGA	0.692000													3	5					0	0	1	0	0
DNAJC2	27000	broad.mit.edu	37	7	102960101	102960101	+	Silent	SNP	G	G	A			TCGA-XF-A8HH-01A-11D-A38G-08	TCGA-XF-A8HH-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f221f317-1da7-437b-9810-d18cc320e339	77ece96f-b1b7-413e-af73-03c11a8f5e91	g.chr7:102960101G>A	ENST00000379263.3	-	12	1447	c.1197C>T	c.(1195-1197)ctC>ctT	p.L399L	DNAJC2_ENST00000249270.7_Intron|PMPCB_ENST00000420236.2_Intron	NM_014377.1	NP_055192.1	Q99543	DNJC2_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 2	399					'de novo' cotranslational protein folding|chromatin modification|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nuclear membrane	chromatin binding|DNA binding|histone binding|Hsp70 protein binding|ubiquitin binding			endometrium(1)|kidney(9)|large_intestine(6)|lung(4)|ovary(1)	21						TGCATGATGTGAGTGTTTCAT	0.353000													9	30					0	0	1	0	0
H1FNT	341567	broad.mit.edu	37	12	48723425	48723425	+	Silent	SNP	C	C	T			TCGA-XF-A8HH-01A-11D-A38G-08	TCGA-XF-A8HH-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f221f317-1da7-437b-9810-d18cc320e339	77ece96f-b1b7-413e-af73-03c11a8f5e91	g.chr12:48723425C>T	ENST00000335017.1	+	1	663	c.351C>T	c.(349-351)gcC>gcT	p.A117A		NM_181788.1	NP_861453.1	Q75WM6	H1FNT_HUMAN	H1 histone family, member N, testis-specific	117					chromosome condensation|multicellular organismal development|sperm chromatin condensation|spermatid nucleus elongation	nuclear chromatin	ATP binding|DNA binding			endometrium(1)|large_intestine(2)|lung(4)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|stomach(1)	13						GCGACGCCGCCGGCTACTTCA	0.721000													4	13					0	0	1	0	0
CENPF	1063	broad.mit.edu	37	1	214826219	214826219	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-A8HH-01A-11D-A38G-08	TCGA-XF-A8HH-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f221f317-1da7-437b-9810-d18cc320e339	77ece96f-b1b7-413e-af73-03c11a8f5e91	g.chr1:214826219G>C	ENST00000366955.3	+	16	8377	c.8209G>C	c.(8209-8211)Gaa>Caa	p.E2737Q	CENPF_ENST00000467765.1_3'UTR	NM_016343.3	NP_057427.3	P49454	CENPF_HUMAN	centromere protein F, 350/400kDa	2833	Sufficient for centromere localization.|Sufficient for self-association.				cell differentiation|cell division|cell proliferation|DNA replication|G2 phase of mitotic cell cycle|kinetochore assembly|metaphase plate congression|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|muscle organ development|negative regulation of transcription, DNA-dependent|protein transport|regulation of G2/M transition of mitotic cell cycle|regulation of striated muscle tissue development|response to drug	condensed chromosome outer kinetochore|cytosol|midbody|nuclear envelope|nuclear matrix|perinuclear region of cytoplasm|spindle pole	chromatin binding|dynein binding|protein C-terminus binding|protein homodimerization activity|transcription factor binding			NS(2)|breast(2)|central_nervous_system(4)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(37)|lung(47)|ovary(7)|prostate(3)|skin(6)|stomach(1)|urinary_tract(1)	126				all cancers(67;0.00836)|OV - Ovarian serous cystadenocarcinoma(81;0.00855)|GBM - Glioblastoma multiforme(131;0.0694)|Epithelial(68;0.0833)		TTCTAAAGAAGAATGTCTCAG	0.348000													17	51					0	0	1	0	0
NARG2	79664	broad.mit.edu	37	15	60741060	60741060	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-A8HH-01A-11D-A38G-08	TCGA-XF-A8HH-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f221f317-1da7-437b-9810-d18cc320e339	77ece96f-b1b7-413e-af73-03c11a8f5e91	g.chr15:60741060C>G	ENST00000261520.4	-	10	2340	c.2106G>C	c.(2104-2106)caG>caC	p.Q702H	NARG2_ENST00000439632.1_Missense_Mutation_p.Q565H	NM_024611.4	NP_078887.2	Q659A1	NARG2_HUMAN	NMDA receptor regulated 2	702						nucleus				breast(1)|central_nervous_system(1)|endometrium(7)|kidney(3)|large_intestine(2)|lung(10)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)	32						CTTTTGGCTTCTGAAATGCAG	0.378000													4	30					0	0	1	0	0
LOC441666	441666	broad.mit.edu	37	10	42832122	42832122	+	RNA	SNP	C	C	T			TCGA-XF-A8HH-01A-11D-A38G-08	TCGA-XF-A8HH-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f221f317-1da7-437b-9810-d18cc320e339	77ece96f-b1b7-413e-af73-03c11a8f5e91	g.chr10:42832122C>T	ENST00000609841.1	-	0	1781					NR_024380.1																						CAGTAAAAGGCTTTGCCACAT	0.348000													3	12					0	0	1	0	0
NBPF1	55672	broad.mit.edu	37	1	16914285	16914285	+	Silent	SNP	G	G	A			TCGA-XF-A8HH-01A-11D-A38G-08	TCGA-XF-A8HH-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f221f317-1da7-437b-9810-d18cc320e339	77ece96f-b1b7-413e-af73-03c11a8f5e91	g.chr1:16914285G>A	ENST00000430580.2	-	10	1388	c.501C>T	c.(499-501)gaC>gaT	p.D167D		NM_017940.3	NP_060410.2	Q3BBV0	NBPF1_HUMAN	neuroblastoma breakpoint family, member 1	167	NBPF 1.					cytoplasm									UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.52e-06)|COAD - Colon adenocarcinoma(227;1.05e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.179)		CCTCATCTTCGTCATTTTCTG	0.433000													22	433					0	0	1	0	0
SLC30A4	7782	broad.mit.edu	37	15	45814199	45814199	+	Silent	SNP	G	G	C			TCGA-XF-A8HH-01A-11D-A38G-08	TCGA-XF-A8HH-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f221f317-1da7-437b-9810-d18cc320e339	77ece96f-b1b7-413e-af73-03c11a8f5e91	g.chr15:45814199G>C	ENST00000261867.4	-	2	668	c.354C>G	c.(352-354)gcC>gcG	p.A118A	SLC30A4_ENST00000559667.1_5'UTR|HMGN2P46_ENST00000409454.1_RNA	NM_013309.4	NP_037441.2	O14863	ZNT4_HUMAN	solute carrier family 30 (zinc transporter), member 4	118					regulation of sequestering of zinc ion|response to toxin	endosome membrane|integral to membrane|late endosome	zinc ion transmembrane transporter activity			endometrium(3)|large_intestine(2)|lung(8)|prostate(1)|stomach(1)	15		Lung NSC(122;3.55e-06)|all_lung(180;2.56e-05)|Melanoma(134;0.027)		all cancers(107;1.58e-16)|GBM - Glioblastoma multiforme(94;2.15e-06)		AGTACAGAACGGCAGCAATGG	0.463000													20	36					0	0	1	0	0
PAGE5	90737	broad.mit.edu	37	X	55247847	55247847	+	Nonsense_Mutation	SNP	C	C	G			TCGA-XF-A8HH-01A-11D-A38G-08	TCGA-XF-A8HH-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f221f317-1da7-437b-9810-d18cc320e339	77ece96f-b1b7-413e-af73-03c11a8f5e91	g.chrX:55247847C>G	ENST00000289619.5	+	2	337	c.92C>G	c.(91-93)tCa>tGa	p.S31*	PAGE5_ENST00000374952.1_Nonsense_Mutation_p.S11*|PAGE5_ENST00000374955.3_Nonsense_Mutation_p.S11*	NM_130467.3	NP_569734.2	Q96GU1	GGEE1_HUMAN	P antigen family, member 5 (prostate associated)	31										breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(3)	8						TCCCAATCCTCAGAAAGAGGA	0.333000													10	57					0	0	1	0	0
COL15A1	1306	broad.mit.edu	37	9	101748257	101748257	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-A8HH-01A-11D-A38G-08	TCGA-XF-A8HH-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f221f317-1da7-437b-9810-d18cc320e339	77ece96f-b1b7-413e-af73-03c11a8f5e91	g.chr9:101748257G>A	ENST00000375001.3	+	3	934	c.511G>A	c.(511-513)Gag>Aag	p.E171K		NM_001855.3	NP_001846.3	P39059	COFA1_HUMAN	collagen, type XV, alpha 1	171	TSP N-terminal.				angiogenesis|cell differentiation|signal transduction	collagen type XV|extracellular space|integral to membrane	binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(20)|liver(1)|lung(42)|ovary(6)|prostate(5)|skin(6)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	107		Acute lymphoblastic leukemia(62;0.0562)				TGTCCAGGGTGAGGAAGTGAC	0.597000													20	73					0	0	1	0	0
FAM76B	143684	broad.mit.edu	37	11	95504794	95504794	+	Silent	SNP	G	G	C			TCGA-XF-A8HH-01A-11D-A38G-08	TCGA-XF-A8HH-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f221f317-1da7-437b-9810-d18cc320e339	77ece96f-b1b7-413e-af73-03c11a8f5e91	g.chr11:95504794G>C	ENST00000358780.5	-	10	1263	c.951C>G	c.(949-951)ctC>ctG	p.L317L	FAM76B_ENST00000536839.1_Silent_p.L316L	NM_144664.4	NP_653265.3	Q5HYJ3	FA76B_HUMAN	family with sequence similarity 76, member B	317										breast(1)|kidney(1)|lung(1)	3		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)				CGACCTGTTTGAGTAGTTCTC	0.313000													20	46					0	0	1	0	0
NARG2	79664	broad.mit.edu	37	15	60741548	60741548	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-A8HH-01A-11D-A38G-08	TCGA-XF-A8HH-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f221f317-1da7-437b-9810-d18cc320e339	77ece96f-b1b7-413e-af73-03c11a8f5e91	g.chr15:60741548C>T	ENST00000261520.4	-	10	1852	c.1618G>A	c.(1618-1620)Gaa>Aaa	p.E540K	NARG2_ENST00000439632.1_Missense_Mutation_p.E403K	NM_024611.4	NP_078887.2	Q659A1	NARG2_HUMAN	NMDA receptor regulated 2	540						nucleus				breast(1)|central_nervous_system(1)|endometrium(7)|kidney(3)|large_intestine(2)|lung(10)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)	32						TTAGGTCTTTCACCATCAGCA	0.343000													16	51					0	0	1	0	0
NFATC1	4772	broad.mit.edu	37	18	77246360	77246360	+	Silent	SNP	G	G	A			TCGA-XF-A8HH-01A-11D-A38G-08	TCGA-XF-A8HH-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f221f317-1da7-437b-9810-d18cc320e339	77ece96f-b1b7-413e-af73-03c11a8f5e91	g.chr18:77246360G>A	ENST00000253506.5	+	9	2574	c.2205G>A	c.(2203-2205)gcG>gcA	p.A735A	NFATC1_ENST00000397790.2_Silent_p.A263A|NFATC1_ENST00000542384.1_Intron|NFATC1_ENST00000318065.5_Silent_p.A722A|NFATC1_ENST00000329101.4_Silent_p.A722A|NFATC1_ENST00000545796.1_Silent_p.A263A|NFATC1_ENST00000427363.2_Silent_p.A735A|NFATC1_ENST00000586434.1_Intron	NM_006162.3	NP_006153.2	O95644	NFAC1_HUMAN	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1	0	Trans-activation domain B (TAD-B).				intracellular signal transduction|positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|nucleus	FK506 binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			NS(2)|breast(1)|endometrium(7)|kidney(1)|large_intestine(4)|lung(17)|ovary(2)|prostate(4)|skin(1)|soft_tissue(1)	40		Esophageal squamous(42;0.0157)|Melanoma(33;0.144)		OV - Ovarian serous cystadenocarcinoma(15;3.73e-07)|BRCA - Breast invasive adenocarcinoma(31;0.0257)		AGCAGCTCGCGATGCCACCCG	0.637000													55	127					0	0	1	0	0
KCTD19	146212	broad.mit.edu	37	16	67327997	67327997	+	Silent	SNP	G	G	C			TCGA-XF-A8HH-01A-11D-A38G-08	TCGA-XF-A8HH-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f221f317-1da7-437b-9810-d18cc320e339	77ece96f-b1b7-413e-af73-03c11a8f5e91	g.chr16:67327997G>C	ENST00000304372.5	-	12	1723	c.1668C>G	c.(1666-1668)gtC>gtG	p.V556V		NM_001100915.1	NP_001094385.1	Q17RG1	KCD19_HUMAN	potassium channel tetramerization domain containing 19	556						voltage-gated potassium channel complex	voltage-gated potassium channel activity			endometrium(3)|large_intestine(7)|lung(8)|ovary(1)|prostate(1)|skin(3)	23		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0311)|Epithelial(162;0.0906)		GGTTGGACCTGACCAGGTTTC	0.562000													54	131					0	0	1	0	0
HS3ST3B1	9953	broad.mit.edu	37	17	14205045	14205045	+	Silent	SNP	C	C	T			TCGA-XF-A8HH-01A-11D-A38G-08	TCGA-XF-A8HH-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f221f317-1da7-437b-9810-d18cc320e339	77ece96f-b1b7-413e-af73-03c11a8f5e91	g.chr17:14205045C>T	ENST00000360954.2	+	1	646	c.210C>T	c.(208-210)gcC>gcT	p.A70A		NM_006041.1	NP_006032.1	Q9Y662	HS3SB_HUMAN	heparan sulfate (glucosamine) 3-O-sulfotransferase 3B1	70					heparan sulfate proteoglycan biosynthetic process, enzymatic modification	Golgi membrane|integral to plasma membrane	[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity|[heparan sulfate]-glucosamine 3-sulfotransferase 3 activity			large_intestine(3)|lung(3)|skin(1)	7				UCEC - Uterine corpus endometrioid carcinoma (92;0.0887)		GGTCCCGCGCCGCACACGACC	0.731000													6	6					0	0	1	0	0
ZNF830	91603	broad.mit.edu	37	17	33288602	33288602	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-A8HH-01A-11D-A38G-08	TCGA-XF-A8HH-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f221f317-1da7-437b-9810-d18cc320e339	77ece96f-b1b7-413e-af73-03c11a8f5e91	g.chr17:33288602C>T	ENST00000361952.3	+	1	54	c.17C>T	c.(16-18)tCc>tTc	p.S6F		NM_052857.3	NP_443089.3	Q96NB3	ZN830_HUMAN	zinc finger protein 830	6					cell division|mitosis	cytoplasm|nucleus	metal ion binding			breast(1)|cervix(1)|endometrium(2)|large_intestine(1)|liver(2)|lung(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	13		Ovarian(249;0.17)				TCCTCCGCCTCCGCCCGGACT	0.567000													24	77					0	0	1	0	0
GDAP2	54834	broad.mit.edu	37	1	118455250	118455250	+	Silent	SNP	G	G	A			TCGA-XF-A8HH-01A-11D-A38G-08	TCGA-XF-A8HH-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f221f317-1da7-437b-9810-d18cc320e339	77ece96f-b1b7-413e-af73-03c11a8f5e91	g.chr1:118455250G>A	ENST00000369443.5	-	4	621	c.372C>T	c.(370-372)ttC>ttT	p.F124F	GDAP2_ENST00000369442.3_Silent_p.F124F	NM_017686.3	NP_060156.1	Q9NXN4	GDAP2_HUMAN	ganglioside induced differentiation associated protein 2		Macro.									kidney(2)|large_intestine(3)|lung(9)|ovary(2)	16		all_cancers(81;0.0156)|all_lung(203;5.81e-05)|Lung NSC(69;0.000446)|all_epithelial(167;0.00295)		Lung(183;0.0583)|LUSC - Lung squamous cell carcinoma(189;0.194)		TGTGAATGATGAACCGGGCAG	0.423000													32	92					0	0	1	0	0
TRIP4	9325	broad.mit.edu	37	15	64706352	64706352	+	Missense_Mutation	SNP	C	C	A			TCGA-XF-A8HH-01A-11D-A38G-08	TCGA-XF-A8HH-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f221f317-1da7-437b-9810-d18cc320e339	77ece96f-b1b7-413e-af73-03c11a8f5e91	g.chr15:64706352C>A	ENST00000261884.3	+	8	1172	c.1112C>A	c.(1111-1113)tCt>tAt	p.S371Y		NM_016213.4	NP_057297.2	Q15650	TRIP4_HUMAN	thyroid hormone receptor interactor 4	371					positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|nucleus	ligand-dependent nuclear receptor binding|transcription coactivator activity|zinc ion binding			breast(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(5)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	21						TTGGATAGATCTTCTGAAGAG	0.438000													10	56					0.000673444	0.000693976	1	1	0
FAM172A	83989	broad.mit.edu	37	5	93294586	93294586	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-A8HH-01A-11D-A38G-08	TCGA-XF-A8HH-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f221f317-1da7-437b-9810-d18cc320e339	77ece96f-b1b7-413e-af73-03c11a8f5e91	g.chr5:93294586G>A	ENST00000395965.3	-	6	605	c.463C>T	c.(463-465)Cat>Tat	p.H155Y	FAM172A_ENST00000504768.2_5'UTR|FAM172A_ENST00000505869.1_Intron|FAM172A_ENST00000509163.1_Missense_Mutation_p.H109Y|FAM172A_ENST00000509739.1_Intron	NM_032042.5	NP_114431.2	Q8WUF8	F172A_HUMAN	family with sequence similarity 172, member A	155						endoplasmic reticulum|extracellular region				endometrium(2)|large_intestine(2)|lung(4)|upper_aerodigestive_tract(1)	9						CCACTACCATGAATTAAAACC	0.393000													34	63					0	0	1	0	0
NPAS3	64067	broad.mit.edu	37	14	34268993	34268993	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-A8HH-01A-11D-A38G-08	TCGA-XF-A8HH-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f221f317-1da7-437b-9810-d18cc320e339	77ece96f-b1b7-413e-af73-03c11a8f5e91	g.chr14:34268993G>A	ENST00000346562.2	+	11	1458	c.1384G>A	c.(1384-1386)Gaa>Aaa	p.E462K	NPAS3_ENST00000357798.5_Missense_Mutation_p.E481K|NPAS3_ENST00000551492.1_Missense_Mutation_p.E499K|NPAS3_ENST00000356141.4_Missense_Mutation_p.E494K|NPAS3_ENST00000548645.1_Missense_Mutation_p.E464K	NM_001164749.1|NM_001165893.1|NM_022123.2|NM_173159.2	NP_001158221.1|NP_001159365.1|NP_071406.1|NP_775182.1	Q8IXF0	NPAS3_HUMAN	neuronal PAS domain protein 3	494					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|signal transducer activity			breast(4)|endometrium(3)|kidney(1)|large_intestine(6)|liver(2)|lung(14)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	40	Breast(36;0.0102)|Hepatocellular(127;0.133)		LUAD - Lung adenocarcinoma(48;0.00169)|Lung(238;0.00968)	GBM - Glioblastoma multiforme(1;1.31e-09)|all cancers(1;0.000112)|OV - Ovarian serous cystadenocarcinoma(311;0.115)		CGAGAACAGCGAAGACCCGGA	0.652000													3	7					0	0	1	0	0
F12	2161	broad.mit.edu	37	5	176829575	176829575	+	Silent	SNP	G	G	A			TCGA-XF-A8HH-01A-11D-A38G-08	TCGA-XF-A8HH-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f221f317-1da7-437b-9810-d18cc320e339	77ece96f-b1b7-413e-af73-03c11a8f5e91	g.chr5:176829575G>A	ENST00000253496.3	-	13	1704	c.1656C>T	c.(1654-1656)ctC>ctT	p.L552L		NM_000505.3	NP_000496.2	P00748	FA12_HUMAN	coagulation factor XII (Hageman factor)	552	Peptidase S1.				Factor XII activation|fibrinolysis|innate immune response|positive regulation of blood coagulation|positive regulation of fibrinolysis|positive regulation of plasminogen activation|protein autoprocessing|response to misfolded protein|zymogen activation	extracellular space|plasma membrane	serine-type endopeptidase activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(5)|skin(1)|urinary_tract(1)	12	all_cancers(89;2.04e-05)|Renal(175;0.000269)|Lung NSC(126;0.000832)|all_lung(126;0.00152)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			TGCCGCCCTCGAGGAACCCTG	0.682000									Hereditary Angioedema				4	13					0	0	1	0	0
COX17	10063	broad.mit.edu	37	3	119396058	119396058	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-A8HH-01A-11D-A38G-08	TCGA-XF-A8HH-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f221f317-1da7-437b-9810-d18cc320e339	77ece96f-b1b7-413e-af73-03c11a8f5e91	g.chr3:119396058C>T	ENST00000261070.2	-	1	192	c.100G>A	c.(100-102)Gat>Aat	p.D34N	COX17_ENST00000497116.1_Missense_Mutation_p.D34N|COX17_ENST00000484810.1_Missense_Mutation_p.D34N	NM_005694.1	NP_005685.1	Q14061	COX17_HUMAN	COX17 cytochrome c oxidase copper chaperone	34					copper ion transport|generation of precursor metabolites and energy	mitochondrial intermembrane space	copper chaperone activity			central_nervous_system(1)|kidney(1)|large_intestine(1)	3				GBM - Glioblastoma multiforme(114;0.227)		GACCACGCATCGCGCGCCTTC	0.706000													6	11					0	0	1	0	0
MED20	9477	broad.mit.edu	37	6	41874896	41874896	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-A8HH-01A-11D-A38G-08	TCGA-XF-A8HH-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f221f317-1da7-437b-9810-d18cc320e339	77ece96f-b1b7-413e-af73-03c11a8f5e91	g.chr6:41874896C>T	ENST00000265350.4	-	4	633	c.553G>A	c.(553-555)Ggc>Agc	p.G185S	MED20_ENST00000409312.1_3'UTR|MED20_ENST00000467535.1_5'UTR	NM_004275.3	NP_004266.2	Q9H944	MED20_HUMAN	mediator complex subunit 20	185					regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	mediator complex	DNA-directed RNA polymerase activity|protein binding			haematopoietic_and_lymphoid_tissue(2)|large_intestine(1)|lung(1)|pancreas(1)	5	Colorectal(47;0.121)		STAD - Stomach adenocarcinoma(11;0.000204)|Epithelial(12;0.000367)|Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)			TCTGCTGGGCCGTAGACCGCA	0.562000													8	37					0	0	1	0	0
TRPM7	54822	broad.mit.edu	37	15	50902041	50902041	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-A8HH-01A-11D-A38G-08	TCGA-XF-A8HH-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f221f317-1da7-437b-9810-d18cc320e339	77ece96f-b1b7-413e-af73-03c11a8f5e91	g.chr15:50902041C>T	ENST00000313478.7	-	18	2679	c.2398G>A	c.(2398-2400)Gaa>Aaa	p.E800K	TRPM7_ENST00000560955.1_Missense_Mutation_p.E800K	NM_017672.4	NP_060142.3	Q96QT4	TRPM7_HUMAN	transient receptor potential cation channel, subfamily M, member 7	800					cell death	integral to membrane	ATP binding|calcium channel activity|metal ion binding|protein serine/threonine kinase activity			breast(3)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(17)|lung(13)|ovary(4)|pancreas(1)|skin(4)|stomach(3)	52				all cancers(107;0.000819)|GBM - Glioblastoma multiforme(94;0.0045)		AAGTTGTTTTCGCTGTCATCC	0.353000													17	55					0	0	1	0	0
KANK1	23189	broad.mit.edu	37	9	711641	711641	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-A8HH-01A-11D-A38G-08	TCGA-XF-A8HH-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f221f317-1da7-437b-9810-d18cc320e339	77ece96f-b1b7-413e-af73-03c11a8f5e91	g.chr9:711641C>G	ENST00000382303.1	+	7	1527	c.875C>G	c.(874-876)tCt>tGt	p.S292C	KANK1_ENST00000382293.3_Missense_Mutation_p.S134C|KANK1_ENST00000489369.1_3'UTR|KANK1_ENST00000382297.2_Missense_Mutation_p.S292C	NM_001256876.1	NP_001243805.1	Q14678	KANK1_HUMAN	KN motif and ankyrin repeat domains 1	292					negative regulation of actin filament polymerization	cytoplasm				autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(3)|large_intestine(9)|lung(8)|ovary(3)|pancreas(1)|prostate(3)|stomach(4)|upper_aerodigestive_tract(1)	43		Lung NSC(10;9.84e-12)|all_lung(10;1.02e-11)|Breast(48;0.128)		Epithelial(6;0.000153)|OV - Ovarian serous cystadenocarcinoma(1;0.000358)|Lung(218;0.0222)		GTAAAGATCTCTGTCTTGCAA	0.532000													20	41					0	0	1	0	0
SGOL2	151246	broad.mit.edu	37	2	201435997	201435997	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-A8HH-01A-11D-A38G-08	TCGA-XF-A8HH-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f221f317-1da7-437b-9810-d18cc320e339	77ece96f-b1b7-413e-af73-03c11a8f5e91	g.chr2:201435997G>C	ENST00000357799.4	+	7	1026	c.928G>C	c.(928-930)Gag>Cag	p.E310Q		NM_001160033.1|NM_001160046.1|NM_152524.5	NP_001153505.1|NP_001153518.1|NP_689737.4	Q562F6	SGOL2_HUMAN	shugoshin-like 2 (S. pombe)	310					cell division|mitotic prometaphase	condensed chromosome kinetochore|cytosol|mitotic cohesin complex	protein binding			NS(2)|breast(2)|cervix(3)|endometrium(1)|kidney(2)|large_intestine(7)|lung(20)|ovary(2)|prostate(2)|skin(2)|stomach(1)|urinary_tract(2)	46						TTGCAATAATGAGATAAATGG	0.358000													14	29					0	0	1	0	0
UXS1	80146	broad.mit.edu	37	2	106713228	106713228	+	Missense_Mutation	SNP	C	C	A			TCGA-XF-A8HH-01A-11D-A38G-08	TCGA-XF-A8HH-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f221f317-1da7-437b-9810-d18cc320e339	77ece96f-b1b7-413e-af73-03c11a8f5e91	g.chr2:106713228C>A	ENST00000283148.7	-	14	1189	c.1092G>T	c.(1090-1092)caG>caT	p.Q364H	UXS1_ENST00000540130.1_Missense_Mutation_p.Q302H|UXS1_ENST00000409032.1_Missense_Mutation_p.Q191H|UXS1_ENST00000409501.3_Missense_Mutation_p.Q359H	NM_001253875.1|NM_025076.4	NP_001240804.1|NP_079352.2	Q8NBZ7	UXS1_HUMAN	UDP-glucuronate decarboxylase 1	359					cellular metabolic process	Golgi cisterna membrane|integral to membrane	coenzyme binding|UDP-glucuronate decarboxylase activity			cervix(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(7)|ovary(2)	17						GTTTTCTTTTCTGTGGGTCAT	0.488000													3	7					0.00909568	0.00931618	1	1	0
PBDC1	51260	broad.mit.edu	37	X	75393483	75393483	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-A8HH-01A-11D-A38G-08	TCGA-XF-A8HH-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f221f317-1da7-437b-9810-d18cc320e339	77ece96f-b1b7-413e-af73-03c11a8f5e91	g.chrX:75393483G>A	ENST00000373358.3	+	2	297	c.94G>A	c.(94-96)Gat>Aat	p.D32N	PBDC1_ENST00000373357.3_Missense_Mutation_p.D32N	NM_016500.3	NP_057584.2			polysaccharide biosynthesis domain containing 1																		GTATGGCAACGATGTGAGTAT	0.532000													34	56					0	0	1	0	0
DUOX1	53905	broad.mit.edu	37	15	45442897	45442897	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-A8HH-01A-11D-A38G-08	TCGA-XF-A8HH-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f221f317-1da7-437b-9810-d18cc320e339	77ece96f-b1b7-413e-af73-03c11a8f5e91	g.chr15:45442897C>G	ENST00000321429.4	+	23	3293	c.2886C>G	c.(2884-2886)atC>atG	p.I962M	DUOX1_ENST00000561166.1_Missense_Mutation_p.I608M|DUOX1_ENST00000389037.3_Missense_Mutation_p.I962M	NM_017434.3	NP_059130.2	Q9NRD9	DUOX1_HUMAN	dual oxidase 1	962	Interaction with TXNDC11 (By similarity).		I -> T (in dbSNP:rs16939743).		cuticle development|cytokine-mediated signaling pathway|hormone biosynthetic process|hydrogen peroxide biosynthetic process|hydrogen peroxide catabolic process|response to cAMP|superoxide anion generation	apical plasma membrane|integral to membrane	calcium ion binding|electron carrier activity|flavin adenine dinucleotide binding|heme binding|NAD(P)H oxidase activity|NADP binding|peroxidase activity	p.I962I(1)		breast(2)|central_nervous_system(1)|endometrium(5)|kidney(5)|large_intestine(13)|lung(16)|ovary(6)|prostate(1)|skin(3)|stomach(4)|upper_aerodigestive_tract(1)	57		all_cancers(109;5.7e-11)|all_epithelial(112;4.65e-09)|Lung NSC(122;3.55e-06)|all_lung(180;2.56e-05)|Melanoma(134;0.027)		all cancers(107;5.77e-18)|GBM - Glioblastoma multiforme(94;5.11e-07)|COAD - Colon adenocarcinoma(120;0.071)|Colorectal(133;0.0717)		AGGATATGATCTGGTGAGCAC	0.607000													8	13					0	0	1	0	0
GRHL2	79977	broad.mit.edu	37	8	102589737	102589737	+	Silent	SNP	C	C	G			TCGA-XF-A8HH-01A-11D-A38G-08	TCGA-XF-A8HH-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f221f317-1da7-437b-9810-d18cc320e339	77ece96f-b1b7-413e-af73-03c11a8f5e91	g.chr8:102589737C>G	ENST00000251808.3	+	7	1331	c.993C>G	c.(991-993)gtC>gtG	p.V331V	GRHL2_ENST00000395927.1_Silent_p.V315V	NM_024915.3	NP_079191.2	Q6ISB3	GRHL2_HUMAN	grainyhead-like 2 (Drosophila)	331						cytoplasm|nucleus	DNA binding			breast(3)|central_nervous_system(1)|endometrium(3)|large_intestine(6)|liver(2)|lung(6)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	28	all_cancers(14;4.39e-08)|all_epithelial(15;4.09e-10)|Lung NSC(17;7.11e-06)|all_lung(17;1.44e-05)		Epithelial(11;5.81e-09)|all cancers(13;3.81e-07)|OV - Ovarian serous cystadenocarcinoma(57;0.000213)			AGCAGAGGGTCCTTGACATTG	0.483000													8	83					0	0	1	0	0
PIGR	5284	broad.mit.edu	37	1	207104857	207104857	+	Silent	SNP	G	G	C			TCGA-XF-A8HH-01A-11D-A38G-08	TCGA-XF-A8HH-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f221f317-1da7-437b-9810-d18cc320e339	77ece96f-b1b7-413e-af73-03c11a8f5e91	g.chr1:207104857G>C	ENST00000356495.4	-	10	2367	c.2184C>G	c.(2182-2184)ccC>ccG	p.P728P	PIGR_ENST00000487208.1_5'UTR	NM_002644.3	NP_002635.2	P01833	PIGR_HUMAN	polymeric immunoglobulin receptor	728						extracellular region|integral to plasma membrane	protein binding	p.P728P(1)		central_nervous_system(2)|endometrium(5)|kidney(3)|large_intestine(7)|lung(15)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|stomach(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	45						TTGCCTTCTTGGGTTCTTTGG	0.483000													22	33					0	0	1	0	0
ANO2	57101	broad.mit.edu	37	12	6030527	6030527	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-A8HH-01A-11D-A38G-08	TCGA-XF-A8HH-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f221f317-1da7-437b-9810-d18cc320e339	77ece96f-b1b7-413e-af73-03c11a8f5e91	g.chr12:6030527G>C	ENST00000356134.5	-	3	272	c.201C>G	c.(199-201)atC>atG	p.I67M	ANO2_ENST00000327087.8_Missense_Mutation_p.I67M|ANO2_ENST00000546188.1_Missense_Mutation_p.I67M	NM_001278596.1	NP_001265525.1	Q9NQ90	ANO2_HUMAN	anoctamin 2	71						chloride channel complex|plasma membrane	intracellular calcium activated chloride channel activity			central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(11)|lung(23)|ovary(4)|pancreas(1)|prostate(1)|skin(5)|stomach(3)|upper_aerodigestive_tract(1)	58						GATAGTTGTTGATGACCTGGC	0.547000													13	19					0	0	1	0	0
HDAC5	10014	broad.mit.edu	37	17	42168789	42168789	+	Silent	SNP	C	C	T			TCGA-XF-A8HH-01A-11D-A38G-08	TCGA-XF-A8HH-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f221f317-1da7-437b-9810-d18cc320e339	77ece96f-b1b7-413e-af73-03c11a8f5e91	g.chr17:42168789C>T	ENST00000225983.6	-	11	1562	c.1239G>A	c.(1237-1239)acG>acA	p.T413T	HDAC5_ENST00000586802.1_Silent_p.T412T|HDAC5_ENST00000336057.5_Silent_p.T412T|HDAC5_ENST00000393622.2_Silent_p.T412T			Q9UQL6	HDAC5_HUMAN	histone deacetylase 5	412					B cell differentiation|cellular response to insulin stimulus|chromatin remodeling|chromatin silencing|inflammatory response|negative regulation of cell migration involved in sprouting angiogenesis|negative regulation of myotube differentiation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of protein binding|transcription, DNA-dependent	cytoplasm|histone deacetylase complex	histone deacetylase activity (H3-K16 specific)|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|protein kinase C binding|repressing transcription factor binding			central_nervous_system(1)|endometrium(5)|large_intestine(4)|lung(7)|ovary(1)|prostate(2)|skin(1)	21		Breast(137;0.00637)|Prostate(33;0.0313)		BRCA - Breast invasive adenocarcinoma(366;0.118)		TGCCGGTCAGCGTGCCACCCT	0.682000													3	28					0	0	1	0	0
OBSCN	84033	broad.mit.edu	37	1	228462037	228462037	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-A8HH-01A-11D-A38G-08	TCGA-XF-A8HH-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f221f317-1da7-437b-9810-d18cc320e339	77ece96f-b1b7-413e-af73-03c11a8f5e91	g.chr1:228462037G>A	ENST00000570156.2	+	23	6774	c.6700G>A	c.(6700-6702)Gag>Aag	p.E2234K	RP5-1139B12.2_ENST00000602517.1_RNA|OBSCN_ENST00000366709.4_5'UTR|OBSCN_ENST00000359599.6_Missense_Mutation_p.E706K|OBSCN_ENST00000422127.1_Missense_Mutation_p.E1859K|OBSCN_ENST00000366707.4_5'UTR|OBSCN_ENST00000284548.11_Missense_Mutation_p.E1859K	NM_001271223.2	NP_001258152.2	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	1217	Ig-like 22.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			NS(2)|breast(7)|central_nervous_system(5)|cervix(2)|endometrium(30)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(37)|lung(89)|ovary(8)|pancreas(3)|prostate(13)|skin(6)|stomach(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	223		Prostate(94;0.0405)				GATGGTGGCCGAGGGGCCCGT	0.667000													27	47					0	0	1	0	0
CYP3A5	1577	broad.mit.edu	37	7	99247777	99247777	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-A8HH-01A-11D-A38G-08	TCGA-XF-A8HH-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f221f317-1da7-437b-9810-d18cc320e339	77ece96f-b1b7-413e-af73-03c11a8f5e91	g.chr7:99247777C>T	ENST00000343703.5	-	13	1688	c.1302G>A	c.(1300-1302)atG>atA	p.M434I	CYP3A5_ENST00000222982.4_Missense_Mutation_p.M444I|CYP3A5_ENST00000339843.2_3'UTR					cytochrome P450, family 3, subfamily A, polypeptide 5											NS(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(5)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	16	all_epithelial(64;2.77e-08)|Lung NSC(181;0.00396)|all_lung(186;0.00659)|Esophageal squamous(72;0.0166)					GAGCAAACCTCATGCCAATGC	0.403000													42	110					0	0	1	0	0
MYL9	10398	broad.mit.edu	37	20	35176535	35176535	+	Silent	SNP	C	C	T	rs149515934		TCGA-XF-A8HH-01A-11D-A38G-08	TCGA-XF-A8HH-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f221f317-1da7-437b-9810-d18cc320e339	77ece96f-b1b7-413e-af73-03c11a8f5e91	g.chr20:35176535C>T	ENST00000279022.2	+	3	389	c.285C>T	c.(283-285)aaC>aaT	p.N95N	MYL9_ENST00000346786.2_Intron|RP5-977B1.7_ENST00000439595.1_RNA|RP5-977B1.7_ENST00000425233.1_RNA	NM_006097.4	NP_006088.2	P24844	MYL9_HUMAN	myosin, light chain 9, regulatory	95					axon guidance|muscle contraction|regulation of muscle contraction	cytosol|muscle myosin complex	calcium ion binding|structural constituent of muscle			endometrium(2)|kidney(1)|large_intestine(3)|lung(2)	8	Breast(12;0.0192)	Myeloproliferative disorder(115;0.00878)				AGAAGCTGAACGGCACGGACC	0.607000													3	37					0	0	1	0	0
TP73	7161	broad.mit.edu	37	1	3624130	3624130	+	Silent	SNP	G	G	A			TCGA-XF-A8HH-01A-11D-A38G-08	TCGA-XF-A8HH-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f221f317-1da7-437b-9810-d18cc320e339	77ece96f-b1b7-413e-af73-03c11a8f5e91	g.chr1:3624130G>A	ENST00000378295.4	+	4	359	c.204G>A	c.(202-204)ctG>ctA	p.L68L	TP73_ENST00000346387.4_Silent_p.L68L|TP73_ENST00000604479.1_Silent_p.L68L|TP73_ENST00000378290.4_5'UTR|TP73_ENST00000357733.3_Silent_p.L68L|TP73_ENST00000378285.1_Silent_p.L19L|TP73_ENST00000378288.4_Silent_p.L19L|TP73_ENST00000354437.4_Silent_p.L68L|TP73_ENST00000603362.1_Silent_p.L68L|TP73_ENST00000378280.1_Silent_p.L19L|TP73_ENST00000604074.1_Silent_p.L68L	NM_001204185.1|NM_005427.3	NP_001191114.1|NP_005418.1	O15350	P73_HUMAN	tumor protein p73	68					cellular response to UV|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|mismatch repair|mitotic cell cycle G1/S transition DNA damage checkpoint|negative regulation of JUN kinase activity|negative regulation of neuron apoptosis|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|protein tetramerization|response to gamma radiation|response to X-ray	chromatin|cytosol|transcription factor complex	chromatin binding|damaged DNA binding|double-stranded DNA binding|metal ion binding|p53 binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription regulatory region DNA binding|transcription repressor activity			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|lung(8)|ovary(1)|prostate(1)	20	all_cancers(77;0.0395)|Ovarian(185;0.0634)|Lung NSC(156;0.188)|all_lung(157;0.198)	all_epithelial(116;7.42e-17)|all_lung(118;1.86e-06)|Lung NSC(185;0.000163)|Renal(390;0.00357)|Breast(487;0.00446)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Lung SC(97;0.109)|Ovarian(437;0.127)		Epithelial(90;5.57e-38)|OV - Ovarian serous cystadenocarcinoma(86;1.87e-22)|GBM - Glioblastoma multiforme(42;5.72e-16)|Colorectal(212;2.22e-05)|COAD - Colon adenocarcinoma(227;8.48e-05)|Kidney(185;0.000539)|BRCA - Breast invasive adenocarcinoma(365;0.000868)|STAD - Stomach adenocarcinoma(132;0.0072)|KIRC - Kidney renal clear cell carcinoma(229;0.00751)|Lung(427;0.226)		TCAATCTGCTGAGCAGCACCA	0.657000													27	94					0	0	1	0	0
ZNF429	353088	broad.mit.edu	37	19	21720515	21720515	+	Nonsense_Mutation	SNP	C	C	T			TCGA-XF-A8HH-01A-11D-A38G-08	TCGA-XF-A8HH-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f221f317-1da7-437b-9810-d18cc320e339	77ece96f-b1b7-413e-af73-03c11a8f5e91	g.chr19:21720515C>T	ENST00000358491.4	+	4	1868	c.1660C>T	c.(1660-1662)Caa>Taa	p.Q554*	ZNF429_ENST00000597078.1_Intron	NM_001001415.2	NP_001001415.2	Q86V71	ZN429_HUMAN	zinc finger protein 429	554					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(2)|kidney(2)|large_intestine(13)|lung(10)|ovary(2)|pancreas(1)|prostate(1)|soft_tissue(1)|upper_aerodigestive_tract(2)	34						AAGACTTACTCAACATAAGAA	0.358000													14	64					0	0	1	0	0
DLEC1	9940	broad.mit.edu	37	3	38136501	38136501	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-A8HH-01A-11D-A38G-08	TCGA-XF-A8HH-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f221f317-1da7-437b-9810-d18cc320e339	77ece96f-b1b7-413e-af73-03c11a8f5e91	g.chr3:38136501G>A	ENST00000308059.6	+	13	2072	c.2051G>A	c.(2050-2052)aGa>aAa	p.R684K	DLEC1_ENST00000346219.3_Missense_Mutation_p.R684K|DLEC1_ENST00000452631.2_Missense_Mutation_p.R684K			Q9Y238	DLEC1_HUMAN	deleted in lung and esophageal cancer 1	684					negative regulation of cell proliferation	cytoplasm				NS(1)|breast(3)|central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(14)|ovary(3)|pancreas(3)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)	51				KIRC - Kidney renal clear cell carcinoma(284;0.0664)|Kidney(284;0.0827)		ATCATGCCCAGAAAGGGGGTT	0.537000													24	49					0	0	1	0	0
TP53	7157	broad.mit.edu	37	17	7579415	7579415	+	Nonsense_Mutation	SNP	C	C	T			TCGA-XF-A8HH-01A-11D-A38G-08	TCGA-XF-A8HH-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f221f317-1da7-437b-9810-d18cc320e339	77ece96f-b1b7-413e-af73-03c11a8f5e91	g.chr17:7579415C>T	ENST00000420246.2	-	4	404	c.272G>A	c.(271-273)tGg>tAg	p.W91*	TP53_ENST00000455263.2_Nonsense_Mutation_p.W91*|TP53_ENST00000269305.4_Nonsense_Mutation_p.W91*|TP53_ENST00000445888.2_Nonsense_Mutation_p.W91*|TP53_ENST00000359597.4_Nonsense_Mutation_p.W91*|TP53_ENST00000413465.2_Nonsense_Mutation_p.W91*	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	91	Interaction with WWOX.		W -> C (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.0?(8)|p.W91*(7)|p.G59fs*23(3)|p.V73fs*9(1)|p.D48fs*55(1)|p.A88fs*52(1)|p.W91fs*13(1)|p.P87fs*54(1)|p.P13fs*18(1)|p.S33fs*23(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		TGACAGGGGCCAGGAGGGGGC	0.632000		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			26	35					0	0	1	0	0
NPAS1	4861	broad.mit.edu	37	19	47548576	47548576	+	Silent	SNP	C	C	T			TCGA-XF-A8HH-01A-11D-A38G-08	TCGA-XF-A8HH-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f221f317-1da7-437b-9810-d18cc320e339	77ece96f-b1b7-413e-af73-03c11a8f5e91	g.chr19:47548576C>T	ENST00000602212.1	+	12	1660	c.1440C>T	c.(1438-1440)gaC>gaT	p.D480D	NPAS1_ENST00000602189.1_Silent_p.D305D|NPAS1_ENST00000439365.2_3'UTR|NPAS1_ENST00000449844.2_Silent_p.D480D			Q99742	NPAS1_HUMAN	neuronal PAS domain protein 1	480					central nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			endometrium(2)|kidney(1)|large_intestine(2)|lung(1)	6		all_cancers(25;4.31e-08)|all_epithelial(76;2.96e-06)|all_lung(116;7.86e-06)|Lung NSC(112;2.31e-05)|all_neural(266;0.026)|Ovarian(192;0.0392)|Breast(70;0.102)		all cancers(93;6.02e-05)|OV - Ovarian serous cystadenocarcinoma(262;7.35e-05)|Epithelial(262;0.00389)|GBM - Glioblastoma multiforme(486;0.0252)		ACAGTGGCGACGAGGATCCCT	0.687000													5	23					0	0	1	0	0
TUBB8P7	197331	broad.mit.edu	37	16	90161926	90161926	+	RNA	SNP	T	T	C	rs8061283	by1000genomes	TCGA-XF-A8HH-01A-11D-A38G-08	TCGA-XF-A8HH-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f221f317-1da7-437b-9810-d18cc320e339	77ece96f-b1b7-413e-af73-03c11a8f5e91	g.chr16:90161926T>C	ENST00000567960.1	+	0	662				TUBB8P7_ENST00000564451.1_RNA														p.I221T(3)									CCCACACCCATCTATGGTGAC	0.527000													3	26					0	0	1	0	0
ARID2	196528	broad.mit.edu	37	12	46230579	46230579	+	Silent	SNP	G	G	A			TCGA-XF-A8HH-01A-11D-A38G-08	TCGA-XF-A8HH-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f221f317-1da7-437b-9810-d18cc320e339	77ece96f-b1b7-413e-af73-03c11a8f5e91	g.chr12:46230579G>A	ENST00000334344.6	+	8	1000	c.828G>A	c.(826-828)ctG>ctA	p.L276L	ARID2_ENST00000479608.1_3'UTR|ARID2_ENST00000422737.1_Silent_p.L127L	NM_152641.2	NP_689854.2	Q68CP9	ARID2_HUMAN	AT rich interactive domain 2 (ARID, RFX-like)	276					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(7)|central_nervous_system(3)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(21)|liver(20)|lung(34)|ovary(7)|pancreas(1)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	116	Lung SC(27;0.192)|Renal(347;0.236)	Lung NSC(34;0.106)|all_lung(34;0.22)	OV - Ovarian serous cystadenocarcinoma(5;0.00691)	GBM - Glioblastoma multiforme(48;0.0153)		CTCGAAAGCTGGGCATTAACG	0.368000			"""N, S, F"""		hepatocellular carcinoma								23	54					0	0	1	0	0
PARP1	142	broad.mit.edu	37	1	226570804	226570804	+	Silent	SNP	G	G	A			TCGA-XF-A8HH-01A-11D-A38G-08	TCGA-XF-A8HH-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f221f317-1da7-437b-9810-d18cc320e339	77ece96f-b1b7-413e-af73-03c11a8f5e91	g.chr1:226570804G>A	ENST00000366794.5	-	8	1235	c.1092C>T	c.(1090-1092)tcC>tcT	p.S364S		NM_001618.3	NP_001609.2	P09874	PARP1_HUMAN	poly (ADP-ribose) polymerase 1	364					cellular response to insulin stimulus|protein ADP-ribosylation|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nuclear envelope|nucleolus|transcription factor complex	DNA binding|identical protein binding|NAD+ ADP-ribosyltransferase activity|protein N-terminus binding|transcription factor binding|zinc ion binding			breast(2)|endometrium(4)|kidney(4)|large_intestine(8)|lung(15)|ovary(3)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)	44	Breast(184;0.133)			GBM - Glioblastoma multiforme(131;0.0531)		TGGCCGCCACGGAGGCGCTGG	0.512000								Poly(ADP-ribose) polymerase (PARP) enzymes that bind to DNA					36	172					0	0	1	0	0
WDR72	256764	broad.mit.edu	37	15	53908364	53908364	+	Missense_Mutation	SNP	T	T	A			TCGA-XF-A8HH-01A-11D-A38G-08	TCGA-XF-A8HH-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f221f317-1da7-437b-9810-d18cc320e339	77ece96f-b1b7-413e-af73-03c11a8f5e91	g.chr15:53908364T>A	ENST00000396328.1	-	15	2278	c.2039A>T	c.(2038-2040)cAt>cTt	p.H680L	WDR72_ENST00000559418.1_Missense_Mutation_p.H690L|WDR72_ENST00000360509.5_Missense_Mutation_p.H680L|WDR72_ENST00000557913.1_Missense_Mutation_p.H677L	NM_001277176.1|NM_182758.2	NP_001264105.1|NP_877435.3	Q3MJ13	WDR72_HUMAN	WD repeat domain 72	680										NS(1)|breast(1)|endometrium(4)|kidney(4)|large_intestine(18)|lung(29)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	71				all cancers(107;0.0511)		TAGAAGAATATGAAAGCCAAC	0.393000													14	53					0	0	1	0	0
KCTD19	146212	broad.mit.edu	37	16	67327899	67327899	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-A8HH-01A-11D-A38G-08	TCGA-XF-A8HH-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f221f317-1da7-437b-9810-d18cc320e339	77ece96f-b1b7-413e-af73-03c11a8f5e91	g.chr16:67327899G>A	ENST00000304372.5	-	12	1821	c.1766C>T	c.(1765-1767)tCa>tTa	p.S589L		NM_001100915.1	NP_001094385.1	Q17RG1	KCD19_HUMAN	potassium channel tetramerization domain containing 19	589						voltage-gated potassium channel complex	voltage-gated potassium channel activity			endometrium(3)|large_intestine(7)|lung(8)|ovary(1)|prostate(1)|skin(3)	23		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0311)|Epithelial(162;0.0906)		ACGGCAGTGTGAGTATGTGCT	0.557000													30	85					0	0	1	0	0
SALL2	6297	broad.mit.edu	37	14	21991188	21991188	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-A8HH-01A-11D-A38G-08	TCGA-XF-A8HH-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f221f317-1da7-437b-9810-d18cc320e339	77ece96f-b1b7-413e-af73-03c11a8f5e91	g.chr14:21991188C>G	ENST00000327430.3	-	2	2968	c.2674G>C	c.(2674-2676)Gag>Cag	p.E892Q	SALL2_ENST00000450879.2_Missense_Mutation_p.E755Q|SALL2_ENST00000538754.1_Intron|SALL2_ENST00000317492.5_Intron	NM_005407.1	NP_005398.1	Q9Y467	SALL2_HUMAN	spalt-like transcription factor 2	892							DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(12)|lung(12)|ovary(2)|skin(6)|urinary_tract(2)	43	all_cancers(95;0.000662)			GBM - Glioblastoma multiforme(265;0.0151)		CTCAGCTCCTCTACCAAGGTC	0.602000													3	32					0	0	1	0	0
ZNF385C	201181	broad.mit.edu	37	17	40179718	40179718	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-A8HH-01A-11D-A38G-08	TCGA-XF-A8HH-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f221f317-1da7-437b-9810-d18cc320e339	77ece96f-b1b7-413e-af73-03c11a8f5e91	g.chr17:40179718C>T	ENST00000436535.3	-	7	1196	c.1196G>A	c.(1195-1197)cGc>cAc	p.R399H	ZNF385C_ENST00000461831.1_5'UTR					zinc finger protein 385C											lung(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	3		all_cancers(22;0.00127)|Breast(137;0.00104)|all_epithelial(22;0.0126)				CCCGGCCAGGCGGTCTTTGTG	0.577000													15	60					0	0	1	0	0
SGOL2	151246	broad.mit.edu	37	2	201436313	201436313	+	Missense_Mutation	SNP	G	G	T			TCGA-XF-A8HH-01A-11D-A38G-08	TCGA-XF-A8HH-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f221f317-1da7-437b-9810-d18cc320e339	77ece96f-b1b7-413e-af73-03c11a8f5e91	g.chr2:201436313G>T	ENST00000357799.4	+	7	1342	c.1244G>T	c.(1243-1245)aGa>aTa	p.R415I		NM_001160033.1|NM_001160046.1|NM_152524.5	NP_001153505.1|NP_001153518.1|NP_689737.4	Q562F6	SGOL2_HUMAN	shugoshin-like 2 (S. pombe)	415					cell division|mitotic prometaphase	condensed chromosome kinetochore|cytosol|mitotic cohesin complex	protein binding			NS(2)|breast(2)|cervix(3)|endometrium(1)|kidney(2)|large_intestine(7)|lung(20)|ovary(2)|prostate(2)|skin(2)|stomach(1)|urinary_tract(2)	46						AGATCAAAGAGACAGTTTAAA	0.338000													22	35					1.96292e-10	2.07334e-10	1	1	0
UBAP1	51271	broad.mit.edu	37	9	34241318	34241318	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-A8HH-01A-11D-A38G-08	TCGA-XF-A8HH-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f221f317-1da7-437b-9810-d18cc320e339	77ece96f-b1b7-413e-af73-03c11a8f5e91	g.chr9:34241318G>A	ENST00000536252.1	+	5	693	c.295G>A	c.(295-297)Gat>Aat	p.D99N	UBAP1_ENST00000297661.4_Missense_Mutation_p.D99N|UBAP1_ENST00000359544.2_Missense_Mutation_p.D99N|UBAP1_ENST00000543944.1_Missense_Mutation_p.D135N|UBAP1_ENST00000540348.1_Missense_Mutation_p.D99N|UBAP1_ENST00000545103.1_Missense_Mutation_p.D163N|UBAP1_ENST00000379186.4_Missense_Mutation_p.D99N	NM_001171203.2	NP_001164674.1	Q9NZ09	UBAP1_HUMAN	ubiquitin associated protein 1	99						cytoplasm				endometrium(4)|kidney(2)|lung(6)|upper_aerodigestive_tract(1)	13			LUSC - Lung squamous cell carcinoma(29;0.00272)			CCCAGAGGGCGATAGCAAAAT	0.502000													14	34					0	0	1	0	0
ZNF814	730051	broad.mit.edu	37	19	58385762	58385762	+	Silent	SNP	C	C	G			TCGA-XF-A8HH-01A-11D-A38G-08	TCGA-XF-A8HH-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f221f317-1da7-437b-9810-d18cc320e339	77ece96f-b1b7-413e-af73-03c11a8f5e91	g.chr19:58385762C>G	ENST00000435989.2	-	3	1230	c.996G>C	c.(994-996)tcG>tcC	p.S332S	ZNF814_ENST00000600634.1_Intron|ZNF814_ENST00000597832.1_Intron|ZNF814_ENST00000595295.1_Intron|ZNF814_ENST00000597342.1_Intron|ZNF814_ENST00000596604.1_Intron	NM_001144989.1	NP_001138461.1	B7Z6K7	ZN814_HUMAN	zinc finger protein 814	332					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding	p.S332S(2)		NS(1)|central_nervous_system(2)|endometrium(3)|kidney(9)|lung(2)|prostate(4)|skin(1)|urinary_tract(3)	25						ATTTGCTAAACGATTTCCCAC	0.358000													2	1					0	0	1	0	0
TECPR2	9895	broad.mit.edu	37	14	102931587	102931587	+	Silent	SNP	C	C	T			TCGA-XF-A8HH-01A-11D-A38G-08	TCGA-XF-A8HH-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f221f317-1da7-437b-9810-d18cc320e339	77ece96f-b1b7-413e-af73-03c11a8f5e91	g.chr14:102931587C>T	ENST00000359520.7	+	17	3976	c.3750C>T	c.(3748-3750)ctC>ctT	p.L1250L	TECPR2_ENST00000558678.1_Silent_p.L1250L	NM_014844.3	NP_055659.2	O15040	TCPR2_HUMAN	tectonin beta-propeller repeat containing 2	1250							protein binding			breast(1)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(7)|lung(21)|ovary(2)|prostate(3)|skin(4)|stomach(1)|urinary_tract(1)	50						ATCCCAGTCTCATGCTTCCAG	0.498000													11	36					0	0	1	0	0
MYRF	745	broad.mit.edu	37	11	61539178	61539178	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-A8HH-01A-11D-A38G-08	TCGA-XF-A8HH-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f221f317-1da7-437b-9810-d18cc320e339	77ece96f-b1b7-413e-af73-03c11a8f5e91	g.chr11:61539178G>A	ENST00000278836.5	+	6	1043	c.947G>A	c.(946-948)cGt>cAt	p.R316H	TMEM258_ENST00000535042.1_Intron|MYRF_ENST00000265460.5_Missense_Mutation_p.R307H	NM_001127392.1	NP_001120864.1			myelin regulatory factor																		AGCATTGCCCGTGTCCAGACA	0.692000													10	92					0	0	1	0	0
RIOK2	55781	broad.mit.edu	37	5	96504509	96504509	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-A8HH-01A-11D-A38G-08	TCGA-XF-A8HH-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f221f317-1da7-437b-9810-d18cc320e339	77ece96f-b1b7-413e-af73-03c11a8f5e91	g.chr5:96504509C>T	ENST00000283109.3	-	7	895	c.827G>A	c.(826-828)cGt>cAt	p.R276H	RIOK2_ENST00000508447.1_Missense_Mutation_p.R276H|CTD-2215E18.1_ENST00000509481.1_Intron	NM_018343.2	NP_060813.2	Q9BVS4	RIOK2_HUMAN	RIO kinase 2	276	Protein kinase.						ATP binding|protein serine/threonine kinase activity			breast(2)|endometrium(2)|kidney(2)|large_intestine(4)|lung(9)|pancreas(1)|prostate(1)|urinary_tract(2)	23		all_cancers(142;0.000125)|all_epithelial(76;8.48e-07)|all_lung(232;0.0131)|Lung NSC(167;0.0161)|Colorectal(57;0.0676)|Ovarian(225;0.105)		COAD - Colon adenocarcinoma(37;0.0657)		GTAGCTGAAACGTTTCATAAA	0.323000													6	77					0	0	1	0	0
PSME2	5721	broad.mit.edu	37	14	24614967	24614967	+	Silent	SNP	G	G	C			TCGA-XF-A8HH-01A-11D-A38G-08	TCGA-XF-A8HH-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f221f317-1da7-437b-9810-d18cc320e339	77ece96f-b1b7-413e-af73-03c11a8f5e91	g.chr14:24614967G>C	ENST00000216802.5	-	3	735	c.96C>G	c.(94-96)ctC>ctG	p.L32L	PSME2_ENST00000471700.2_5'UTR|PSME2_ENST00000560410.1_Silent_p.L21L	NM_002818.2	NP_002809.2	Q9UL46	PSME2_HUMAN	proteasome (prosome, macropain) activator subunit 2 (PA28 beta)	32					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	proteasome activator complex				endometrium(1)|lung(3)|prostate(2)	6				GBM - Glioblastoma multiforme(265;0.00839)		AGAATCTGTAGAGGAATTCCT	0.473000													12	19					0	0	1	0	0
SALL2	6297	broad.mit.edu	37	14	21991527	21991527	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-A8HH-01A-11D-A38G-08	TCGA-XF-A8HH-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f221f317-1da7-437b-9810-d18cc320e339	77ece96f-b1b7-413e-af73-03c11a8f5e91	g.chr14:21991527C>T	ENST00000327430.3	-	2	2629	c.2335G>A	c.(2335-2337)Gat>Aat	p.D779N	SALL2_ENST00000450879.2_Missense_Mutation_p.D642N|SALL2_ENST00000538754.1_Intron|SALL2_ENST00000317492.5_Intron	NM_005407.1	NP_005398.1	Q9Y467	SALL2_HUMAN	spalt-like transcription factor 2	779							DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(12)|lung(12)|ovary(2)|skin(6)|urinary_tract(2)	43	all_cancers(95;0.000662)			GBM - Glioblastoma multiforme(265;0.0151)		GAATCTTCATCAGTCACAtct	0.552000													3	35					0	0	1	0	0
TET1	80312	broad.mit.edu	37	10	70406450	70406450	+	Nonsense_Mutation	SNP	C	C	T			TCGA-XF-A8HH-01A-11D-A38G-08	TCGA-XF-A8HH-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f221f317-1da7-437b-9810-d18cc320e339	77ece96f-b1b7-413e-af73-03c11a8f5e91	g.chr10:70406450C>T	ENST00000373644.4	+	4	4173	c.3964C>T	c.(3964-3966)Cag>Tag	p.Q1322*		NM_030625.2	NP_085128.2	Q8NFU7	TET1_HUMAN	tet methylcytosine dioxygenase 1	1322					DNA demethylation|inner cell mass cell differentiation|negative regulation of methylation-dependent chromatin silencing|stem cell maintenance		iron ion binding|methylcytosine dioxygenase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|structure-specific DNA binding|zinc ion binding			breast(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(2)|ovary(5)|prostate(1)|upper_aerodigestive_tract(2)	21						AATACGGTTTCAGCAGGTTGT	0.502000													8	52					0	0	1	0	0
SIGLEC1	6614	broad.mit.edu	37	20	3678470	3678470	+	Silent	SNP	G	G	T			TCGA-XF-A8HH-01A-11D-A38G-08	TCGA-XF-A8HH-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f221f317-1da7-437b-9810-d18cc320e339	77ece96f-b1b7-413e-af73-03c11a8f5e91	g.chr20:3678470G>T	ENST00000344754.4	-	8	2096	c.2097C>A	c.(2095-2097)tcC>tcA	p.S699S	SIGLEC1_ENST00000202578.4_Silent_p.S699S	NM_023068.3	NP_075556.1	Q9BZZ2	SN_HUMAN	sialic acid binding Ig-like lectin 1, sialoadhesin	699	Ig-like C2-type 6.				cell-cell adhesion|cell-matrix adhesion|endocytosis|inflammatory response	extracellular region|integral to membrane|plasma membrane	sugar binding			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(4)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(5)|liver(2)|lung(24)|ovary(3)|pancreas(4)|prostate(3)|skin(8)|upper_aerodigestive_tract(1)	70						TGGCTGAGGTGGAGGCGTTGC	0.612000													17	24					1.15088e-07	1.20806e-07	1	1	0
PLCB2	5330	broad.mit.edu	37	15	40594234	40594234	+	Splice_Site	SNP	C	C	T			TCGA-XF-A8HH-01A-11D-A38G-08	TCGA-XF-A8HH-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f221f317-1da7-437b-9810-d18cc320e339	77ece96f-b1b7-413e-af73-03c11a8f5e91	g.chr15:40594234C>T	ENST00000260402.3	-	7	756		c.e7-1		PLCB2_ENST00000543785.2_Splice_Site|PLCB2_ENST00000456256.2_Splice_Site|PLCB2_ENST00000557821.1_Splice_Site	NM_001284297.1|NM_004573.2	NP_001271226.1|NP_004564.2	Q00722	PLCB2_HUMAN	phospholipase C, beta 2						activation of phospholipase C activity|intracellular signal transduction|lipid catabolic process|phospholipid metabolic process|synaptic transmission	cytosol	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(13)|ovary(4)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(3)	39		all_cancers(109;9.35e-19)|all_epithelial(112;1.18e-15)|Lung NSC(122;2.45e-11)|all_lung(180;6.47e-10)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;9.38e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0508)		CTGGAAAAAGCTGAAGGGGCA	0.602000													11	30					0	0	1	0	0
NDC80	10403	broad.mit.edu	37	18	2578109	2578109	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-A8HH-01A-11D-A38G-08	TCGA-XF-A8HH-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f221f317-1da7-437b-9810-d18cc320e339	77ece96f-b1b7-413e-af73-03c11a8f5e91	g.chr18:2578109G>A	ENST00000261597.4	+	5	627	c.445G>A	c.(445-447)Gaa>Aaa	p.E149K		NM_006101.2	NP_006092.1	O14777	NDC80_HUMAN	NDC80 kinetochore complex component	149	Interaction with RB1.|Interaction with the N-terminus of CDCA1.|Nuclear localization.				attachment of spindle microtubules to kinetochore|cell division|establishment of mitotic spindle orientation|mitotic prometaphase|mitotic sister chromatid segregation|mitotic spindle organization|phosphatidylinositol-mediated signaling	condensed nuclear chromosome outer kinetochore|cytosol|Ndc80 complex	protein binding			NS(1)|biliary_tract(2)|breast(1)|endometrium(1)|kidney(3)|large_intestine(2)|lung(6)|ovary(2)|prostate(2)|urinary_tract(2)	22						AAAGTTTGAAGAAGAGGTTCC	0.373000													21	70					0	0	1	0	0
PINK1	65018	broad.mit.edu	37	1	20960365	20960365	+	Frame_Shift_Del	DEL	G	G	-	rs45540544		TCGA-XF-A8HH-01A-11D-A38G-08	TCGA-XF-A8HH-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f221f317-1da7-437b-9810-d18cc320e339	77ece96f-b1b7-413e-af73-03c11a8f5e91	g.chr1:20960365delG	ENST00000321556.4	+	1	418	c.324delG	c.(322-324)ctgfs	p.L108fs		NM_032409.2	NP_115785.1	Q9BXM7	PINK1_HUMAN	PTEN induced putative kinase 1	108					cell death|intracellular protein kinase cascade|mitochondrion degradation|peptidyl-serine phosphorylation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of release of cytochrome c from mitochondria|regulation of protein complex assembly|regulation of protein ubiquitination|response to stress	cytosol|integral to membrane|mitochondrial outer membrane	ATP binding|C3HC4-type RING finger domain binding|calcium-dependent protein kinase activity|magnesium ion binding|protein serine/threonine kinase activity|ubiquitin protein ligase binding			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(4)|ovary(2)	14		all_lung(284;2.72e-05)|Lung NSC(340;2.94e-05)|Colorectal(325;3.46e-05)|Renal(390;0.000147)|Breast(348;0.00179)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0182)|COAD - Colon adenocarcinoma(152;1.21e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000146)|Kidney(64;0.000182)|GBM - Glioblastoma multiforme(114;0.000497)|KIRC - Kidney renal clear cell carcinoma(64;0.00269)|STAD - Stomach adenocarcinoma(196;0.00308)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.199)		GGCTAGGGCTGGGCCTCATCG	0.731													2	4	---	---	---	---					
RAD21	5885	broad.mit.edu	37	8	117862883	117862883	+	Frame_Shift_Del	DEL	C	C	-			TCGA-XF-A8HH-01A-11D-A38G-08	TCGA-XF-A8HH-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f221f317-1da7-437b-9810-d18cc320e339	77ece96f-b1b7-413e-af73-03c11a8f5e91	g.chr8:117862883delC	ENST00000297338.2	-	12	1881	c.1594delG	c.(1594-1596)gaafs	p.E532fs	RAD21_ENST00000523986.1_Frame_Shift_Del_p.E36fs|RAD21_ENST00000518055.1_Frame_Shift_Del_p.E77fs	NM_006265.2	NP_006256.1	O60216	RAD21_HUMAN	RAD21 homolog (S. pombe)	532					apoptosis|cell division|chromosome segregation|double-strand break repair|mitotic metaphase/anaphase transition|mitotic prometaphase|protein localization to chromatin|reciprocal meiotic recombination|regulation of transcription from RNA polymerase II promoter	chromosome, centromeric region|cohesin complex|nuclear chromosome|nucleoplasm	protein binding			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(16)|ovary(1)|prostate(1)|skin(1)|stomach(1)	32	all_cancers(13;1.21e-21)|Lung NSC(37;0.000134)|Ovarian(258;0.0172)					TCTtctttttccttctctttc	0.373													18	69	---	---	---	---					
TPTE2P1	646405	broad.mit.edu	37	13	25527490	25527491	+	RNA	INS	-	-	AAAAAG			TCGA-XF-A8HH-01A-11D-A38G-08	TCGA-XF-A8HH-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f221f317-1da7-437b-9810-d18cc320e339	77ece96f-b1b7-413e-af73-03c11a8f5e91	g.chr13:25527490_25527491insAAAAAG	ENST00000429698.1	-	0	282																											AGGAAGGTTCTAAAAAAAATTT	0.252													4	4	---	---	---	---					
YY1	7528	broad.mit.edu	37	14	100705708	100705710	+	In_Frame_Del	DEL	GAG	GAG	-			TCGA-XF-A8HH-01A-11D-A38G-08	TCGA-XF-A8HH-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f221f317-1da7-437b-9810-d18cc320e339	77ece96f-b1b7-413e-af73-03c11a8f5e91	g.chr14:100705708_100705710delGAG	ENST00000262238.4	+	1	387_389	c.127_129delGAG	c.(127-129)gagdel	p.E47del		NM_003403.3	NP_003394.1	P25490	TYY1_HUMAN	YY1 transcription factor	47	Asp/Glu-rich (acidic).				cell differentiation|cellular response to UV|double-strand break repair via homologous recombination|negative regulation of transcription from RNA polymerase II promoter|response to UV-C|spermatogenesis	Ino80 complex|nuclear matrix|plasma membrane	four-way junction DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity|transcription regulatory region DNA binding|zinc ion binding	p.E43delE(1)		cervix(1)|endometrium(1)|large_intestine(1)|liver(2)|lung(1)|prostate(4)|skin(1)	11		Melanoma(154;0.152)				AGTggtgggcgaggaggaggagg	0.719													5	8	---	---	---	---					
KDM6A	7403	broad.mit.edu	37	X	44929442	44929442	+	Frame_Shift_Del	DEL	C	C	-			TCGA-XF-A8HH-01A-11D-A38G-08	TCGA-XF-A8HH-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f221f317-1da7-437b-9810-d18cc320e339	77ece96f-b1b7-413e-af73-03c11a8f5e91	g.chrX:44929442delC	ENST00000377967.4	+	17	2583	c.2542delC	c.(2542-2544)cacfs	p.H848fs	KDM6A_ENST00000382899.4_Frame_Shift_Del_p.H855fs|KDM6A_ENST00000543216.1_Frame_Shift_Del_p.H769fs|KDM6A_ENST00000536777.1_Frame_Shift_Del_p.H803fs	NM_021140.2	NP_066963.2	O15550	KDM6A_HUMAN	lysine (K)-specific demethylase 6A	848					histone H3-K4 methylation		metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	p.0?(6)		NS(1)|breast(7)|central_nervous_system(27)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(24)|kidney(24)|large_intestine(9)|liver(1)|lung(21)|oesophagus(11)|pancreas(2)|prostate(5)|skin(1)|soft_tissue(1)|urinary_tract(29)	170						TAACAGCCCTCACAGTGGGCT	0.463			"""D, N, F, S"""		"""renal, oesophageal SCC, MM"""								13	25	---	---	---	---