Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
UBC	7316	broad.mit.edu	37	12	125397183	125397183	+	Missense_Mutation	SNP	C	C	A			TCGA-XF-A9SU-01A-31D-A391-08	TCGA-XF-A9SU-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76efb030-c8f7-41e9-bb9c-5884bdd4bb53	e21da535-cf34-435d-9095-3bc029172d3b	g.chr12:125397183C>A	ENST00000536769.1	-	1	2711	c.1135G>T	c.(1135-1137)Ggt>Tgt	p.G379C	UBC_ENST00000538617.1_Intron|UBC_ENST00000546120.1_Missense_Mutation_p.G303C|UBC_ENST00000339647.5_Missense_Mutation_p.G379C			P0CG48	UBC_HUMAN	ubiquitin C	379	Ubiquitin-like 5.				activation of MAPK activity|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|anti-apoptosis|apoptosis|cellular membrane organization|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA repair|endosome transport|epidermal growth factor receptor signaling pathway|G1/S transition of mitotic cell cycle|I-kappaB kinase/NF-kappaB cascade|induction of apoptosis by extracellular signals|innate immune response|JNK cascade|M/G1 transition of mitotic cell cycle|mRNA metabolic process|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of type I interferon production|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|S phase of mitotic cell cycle|stress-activated MAPK cascade|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|viral reproduction	cytosol|endocytic vesicle membrane|endosome membrane|nucleoplasm|plasma membrane	protein binding			breast(3)|endometrium(4)|kidney(4)|large_intestine(2)|lung(13)|ovary(3)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	36	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;6.17e-05)|Epithelial(86;0.000207)|all cancers(50;0.00308)		TGCATCCCACCTCTGAGACGG	0.517000													4	274					0.014758	0.0149296	1	1	0
FERMT1	55612	broad.mit.edu	37	20	6068460	6068460	+	Silent	SNP	G	G	A			TCGA-XF-A9SU-01A-31D-A391-08	TCGA-XF-A9SU-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76efb030-c8f7-41e9-bb9c-5884bdd4bb53	e21da535-cf34-435d-9095-3bc029172d3b	g.chr20:6068460G>A	ENST00000217289.4	-	11	2123	c.1335C>T	c.(1333-1335)gcC>gcT	p.A445A	FERMT1_ENST00000536936.1_Silent_p.A188A|FERMT1_ENST00000478194.1_5'UTR	NM_017671.4	NP_060141.3	Q9BQL6	FERM1_HUMAN	fermitin family member 1	445	FERM.|PH.				cell adhesion|establishment of epithelial cell polarity|keratinocyte migration|keratinocyte proliferation	cytosol|focal adhesion|ruffle membrane	binding			NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(3)|ovary(1)|pancreas(1)|prostate(2)|skin(2)	17						TCATACCATCGGCAACAGGGA	0.398000													20	81					0	0	1	0	0
PPFIBP1	8496	broad.mit.edu	37	12	27841316	27841316	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-A9SU-01A-31D-A391-08	TCGA-XF-A9SU-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76efb030-c8f7-41e9-bb9c-5884bdd4bb53	e21da535-cf34-435d-9095-3bc029172d3b	g.chr12:27841316C>T	ENST00000318304.8	+	25	2757	c.2474C>T	c.(2473-2475)gCg>gTg	p.A825V	PPFIBP1_ENST00000537927.1_Missense_Mutation_p.A672V|PPFIBP1_ENST00000542629.1_Missense_Mutation_p.A794V|PPFIBP1_ENST00000228425.6_Missense_Mutation_p.A819V	NM_001198916.1|NM_177444.2	NP_001185845.1|NP_803193	Q86W92	LIPB1_HUMAN	PTPRF interacting protein, binding protein 1 (liprin beta 1)	825	SAM 3.				cell adhesion	plasma membrane	protein binding		PPFIBP1/ALK(3)	central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(6)|lung(13)|prostate(2)|skin(1)	32	Lung SC(9;0.0873)					GCAGAATATGCGCCCAATCTC	0.473000													4	255					0	0	1	0	0
ZMAT4	79698	broad.mit.edu	37	8	40532241	40532241	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-A9SU-01A-31D-A391-08	TCGA-XF-A9SU-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76efb030-c8f7-41e9-bb9c-5884bdd4bb53	e21da535-cf34-435d-9095-3bc029172d3b	g.chr8:40532241C>G	ENST00000297737.6	-	5	705	c.559G>C	c.(559-561)Gat>Cat	p.D187H	ZMAT4_ENST00000315769.7_Intron	NM_024645.2	NP_078921.1	Q9H898	ZMAT4_HUMAN	zinc finger, matrin-type 4	187						nucleus	DNA binding|zinc ion binding			NS(2)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(4)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	18	Ovarian(28;0.00724)|Colorectal(14;0.0468)	all_cancers(7;0.00936)|all_epithelial(6;3.53e-06)|all_lung(54;0.0318)|Lung NSC(58;0.0919)|Esophageal squamous(32;0.15)|Hepatocellular(245;0.152)	LUSC - Lung squamous cell carcinoma(45;0.00722)			TCCCCCATATCCAGGGTTGTC	0.453000													21	125					0	0	1	0	0
UBAP1	51271	broad.mit.edu	37	9	34241585	34241585	+	Missense_Mutation	SNP	A	A	G			TCGA-XF-A9SU-01A-31D-A391-08	TCGA-XF-A9SU-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76efb030-c8f7-41e9-bb9c-5884bdd4bb53	e21da535-cf34-435d-9095-3bc029172d3b	g.chr9:34241585A>G	ENST00000536252.1	+	5	960	c.562A>G	c.(562-564)Act>Gct	p.T188A	UBAP1_ENST00000543944.1_Missense_Mutation_p.T224A|UBAP1_ENST00000297661.4_Missense_Mutation_p.T188A|UBAP1_ENST00000359544.2_Missense_Mutation_p.T188A|UBAP1_ENST00000379186.4_Missense_Mutation_p.T188A|UBAP1_ENST00000545103.1_Missense_Mutation_p.T252A|UBAP1_ENST00000540348.1_Missense_Mutation_p.T188A	NM_001171203.2	NP_001164674.1	Q9NZ09	UBAP1_HUMAN	ubiquitin associated protein 1	188						cytoplasm				endometrium(4)|kidney(2)|lung(6)|upper_aerodigestive_tract(1)	13			LUSC - Lung squamous cell carcinoma(29;0.00272)			GGTAGGAACCACTGGACCCAT	0.463000													15	34					0	0	1	0	0
DSCAML1	57453	broad.mit.edu	37	11	117667836	117667836	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-A9SU-01A-31D-A391-08	TCGA-XF-A9SU-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76efb030-c8f7-41e9-bb9c-5884bdd4bb53	e21da535-cf34-435d-9095-3bc029172d3b	g.chr11:117667836C>T	ENST00000321322.6	-	1	140	c.139G>A	c.(139-141)Gcc>Acc	p.A47T		NM_020693.2	NP_065744.2	Q8TD84	DSCL1_HUMAN	Down syndrome cell adhesion molecule like 1	0	Ig-like C2-type 1.				axonogenesis|brain development|cell fate determination|dorsal/ventral pattern formation|embryonic skeletal system morphogenesis|homophilic cell adhesion	cell surface|integral to membrane|plasma membrane	protein homodimerization activity			breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|large_intestine(24)|lung(49)|ovary(6)|pancreas(1)|prostate(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	110	all_hematologic(175;0.0487)	Breast(348;0.0424)|Medulloblastoma(222;0.0523)|all_hematologic(192;0.232)		BRCA - Breast invasive adenocarcinoma(274;9.12e-06)|Epithelial(105;0.00172)		GGTCCTGTGGCCGGCCGTGCG	0.682000													4	11					0	0	1	0	0
BAIAP2L1	55971	broad.mit.edu	37	7	97944836	97944836	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-A9SU-01A-31D-A391-08	TCGA-XF-A9SU-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76efb030-c8f7-41e9-bb9c-5884bdd4bb53	e21da535-cf34-435d-9095-3bc029172d3b	g.chr7:97944836C>T	ENST00000005260.8	-	7	790	c.575G>A	c.(574-576)cGc>cAc	p.R192H	BAIAP2L1_ENST00000462558.1_5'UTR	NM_018842.4	NP_061330.2	Q9UHR4	BI2L1_HUMAN	BAI1-associated protein 2-like 1	192	IMD.				filopodium assembly|positive regulation of actin cytoskeleton reorganization|positive regulation of actin filament polymerization|response to bacterium|signal transduction	cell junction|cytoskeleton|cytosol|nucleus	actin binding|cytoskeletal adaptor activity|proline-rich region binding|SH3 domain binding			NS(1)|breast(1)|cervix(1)|endometrium(3)|large_intestine(7)|lung(8)|ovary(1)|prostate(1)	23	all_cancers(62;4.34e-10)|all_epithelial(64;5e-10)|Esophageal squamous(72;0.00918)|Lung NSC(181;0.0113)|all_lung(186;0.0126)		STAD - Stomach adenocarcinoma(171;0.215)			AAAGCAGAAGCGCCTCTTCTC	0.418000													56	154					0	0	1	0	0
TG	7038	broad.mit.edu	37	8	133880458	133880458	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-A9SU-01A-31D-A391-08	TCGA-XF-A9SU-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76efb030-c8f7-41e9-bb9c-5884bdd4bb53	e21da535-cf34-435d-9095-3bc029172d3b	g.chr8:133880458G>A	ENST00000220616.4	+	2	206	c.166G>A	c.(166-168)Ggc>Agc	p.G56S	TG_ENST00000377869.1_Missense_Mutation_p.G56S	NM_003235.4	NP_003226.4	P01266	THYG_HUMAN	thyroglobulin	56	Thyroglobulin type-1 1.				hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			NS(1)|breast(11)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(34)|liver(2)|lung(59)|ovary(9)|pancreas(2)|prostate(6)|skin(7)|stomach(4)|upper_aerodigestive_tract(4)|urinary_tract(8)	168	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		TGCAGAGGATGGCAGCTTCCA	0.562000													3	34					0	0	1	0	0
MYBBP1A	10514	broad.mit.edu	37	17	4453489	4453489	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-A9SU-01A-31D-A391-08	TCGA-XF-A9SU-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76efb030-c8f7-41e9-bb9c-5884bdd4bb53	e21da535-cf34-435d-9095-3bc029172d3b	g.chr17:4453489C>T	ENST00000254718.4	-	9	1489	c.1183G>A	c.(1183-1185)Gtg>Atg	p.V395M	MYBBP1A_ENST00000381556.2_Missense_Mutation_p.V395M			Q9BQG0	MBB1A_HUMAN	MYB binding protein (P160) 1a	395	Interaction with MYB (By similarity).				nucleocytoplasmic transport|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|NLS-dependent protein nuclear import complex|nucleolus	DNA binding|DNA-directed DNA polymerase activity|transcription factor binding	p.V395L(1)		breast(1)|endometrium(1)|kidney(1)|large_intestine(6)|lung(7)|ovary(3)|prostate(2)|skin(2)|stomach(1)	24						AGGAACCGCACGACCCGCCAG	0.637000													12	69					0	0	1	0	0
C11orf71	54494	broad.mit.edu	37	11	114270864	114270864	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-A9SU-01A-31D-A391-08	TCGA-XF-A9SU-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76efb030-c8f7-41e9-bb9c-5884bdd4bb53	e21da535-cf34-435d-9095-3bc029172d3b	g.chr11:114270864C>T	ENST00000325636.4	-	1	275	c.190G>A	c.(190-192)Gag>Aag	p.E64K	RBM7_ENST00000540163.1_5'UTR	NM_019021.3	NP_061894.2	Q6IPW1	CK071_HUMAN	chromosome 11 open reading frame 71	64										large_intestine(3)|lung(1)	4		all_cancers(61;1.15e-11)|all_epithelial(67;5.3e-06)|all_hematologic(158;0.000303)|Acute lymphoblastic leukemia(157;0.000966)|Melanoma(852;0.00153)|Medulloblastoma(222;0.0523)|all_neural(223;0.0663)|Breast(348;0.0818)|Prostate(24;0.104)		BRCA - Breast invasive adenocarcinoma(274;2.6e-06)|Epithelial(105;4.31e-05)|all cancers(92;0.00036)		CGACGGCTCTCGGCCCGAACG	0.657000													6	35					0	0	1	0	0
RIMS4	140730	broad.mit.edu	37	20	43384864	43384864	+	Missense_Mutation	SNP	T	T	C			TCGA-XF-A9SU-01A-31D-A391-08	TCGA-XF-A9SU-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76efb030-c8f7-41e9-bb9c-5884bdd4bb53	e21da535-cf34-435d-9095-3bc029172d3b	g.chr20:43384864T>C	ENST00000372851.3	-	6	787	c.721A>G	c.(721-723)Atg>Gtg	p.M241V	RIMS4_ENST00000541604.2_Missense_Mutation_p.M242V	NM_001205317.1|NM_182970.3	NP_001192246.1|NP_892015.1	Q9H426	RIMS4_HUMAN	regulating synaptic membrane exocytosis 4	241					exocytosis|neurotransmitter transport	cell junction|synapse				central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(11)|ovary(5)|urinary_tract(1)	29		Myeloproliferative disorder(115;0.0122)				GGGTCCACCATGGAGGAGGTG	0.652000													16	65					0	0	1	0	0
WEE1	7465	broad.mit.edu	37	11	9606861	9606861	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-A9SU-01A-31D-A391-08	TCGA-XF-A9SU-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76efb030-c8f7-41e9-bb9c-5884bdd4bb53	e21da535-cf34-435d-9095-3bc029172d3b	g.chr11:9606861G>A	ENST00000299613.6	+	7	1458	c.703G>A	c.(703-705)Gaa>Aaa	p.E235K	WEE1_ENST00000450114.2_Missense_Mutation_p.E449K	NM_001143976.1	NP_001137448.1	P30291	WEE1_HUMAN	WEE1 G2 checkpoint kinase	449					blood coagulation|cell cycle checkpoint|cell division|G1/S transition of mitotic cell cycle|G2/M transition of mitotic cell cycle|mitosis|S phase of mitotic cell cycle	nucleoplasm	ATP binding|magnesium ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(6)|ovary(1)|prostate(2)|skin(1)|urinary_tract(1)	23				all cancers(16;4.59e-09)|Epithelial(150;3.15e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0484)		AGAAGGAGACGAAGATGATTG	0.328000													9	54					0	0	1	0	0
ATP8B3	148229	broad.mit.edu	37	19	1784821	1784821	+	Silent	SNP	G	G	A			TCGA-XF-A9SU-01A-31D-A391-08	TCGA-XF-A9SU-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76efb030-c8f7-41e9-bb9c-5884bdd4bb53	e21da535-cf34-435d-9095-3bc029172d3b	g.chr19:1784821G>A	ENST00000539485.1	-	28	3920	c.3687C>T	c.(3685-3687)gcC>gcT	p.A1229A	ATP8B3_ENST00000525591.1_Silent_p.A1182A|ATP8B3_ENST00000310127.6_Silent_p.A1219A			O60423	AT8B3_HUMAN	ATPase, aminophospholipid transporter, class I, type 8B, member 3	1219					ATP biosynthetic process		ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			central_nervous_system(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(9)|ovary(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	23		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		ACCTCACCTTGGCACGTAGCT	0.637000													3	11					0	0	1	0	0
XAB2	56949	broad.mit.edu	37	19	7685538	7685538	+	Silent	SNP	G	G	A			TCGA-XF-A9SU-01A-31D-A391-08	TCGA-XF-A9SU-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76efb030-c8f7-41e9-bb9c-5884bdd4bb53	e21da535-cf34-435d-9095-3bc029172d3b	g.chr19:7685538G>A	ENST00000358368.4	-	15	2026	c.1989C>T	c.(1987-1989)caC>caT	p.H663H	XAB2_ENST00000534844.1_Silent_p.H660H	NM_020196.2	NP_064581.2	Q9HCS7	SYF1_HUMAN	XPA binding protein 2	663					transcription, DNA-dependent|transcription-coupled nucleotide-excision repair	catalytic step 2 spliceosome|nucleoplasm	protein binding			breast(1)|central_nervous_system(2)|cervix(2)|endometrium(2)|kidney(2)|large_intestine(2)|lung(11)|prostate(1)|skin(2)|urinary_tract(1)	26						TCTCACGCGCGTGCTCGTCCG	0.657000								Direct reversal of damage;Nucleotide excision repair (NER)					3	40					0	0	1	0	0
CCDC178	374864	broad.mit.edu	37	18	30969585	30969585	+	Missense_Mutation	SNP	T	T	G			TCGA-XF-A9SU-01A-31D-A391-08	TCGA-XF-A9SU-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76efb030-c8f7-41e9-bb9c-5884bdd4bb53	e21da535-cf34-435d-9095-3bc029172d3b	g.chr18:30969585T>G	ENST00000383096.3	-	5	309	c.127A>C	c.(127-129)Atg>Ctg	p.M43L	CCDC178_ENST00000579947.1_Missense_Mutation_p.M43L|CCDC178_ENST00000403303.1_Missense_Mutation_p.M43L|CCDC178_ENST00000300227.8_Missense_Mutation_p.M43L|CCDC178_ENST00000579916.1_Missense_Mutation_p.M43L|CCDC178_ENST00000406524.2_Missense_Mutation_p.M43L|CCDC178_ENST00000402325.1_Missense_Mutation_p.M43L|CCDC178_ENST00000583930.1_Missense_Mutation_p.M43L					coiled-coil domain containing 178																		CTTTGAGACATGGCATTGCCT	0.303000													4	58					0	0	1	0	0
MID1	4281	broad.mit.edu	37	X	10535278	10535278	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-A9SU-01A-31D-A391-08	TCGA-XF-A9SU-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76efb030-c8f7-41e9-bb9c-5884bdd4bb53	e21da535-cf34-435d-9095-3bc029172d3b	g.chrX:10535278G>A	ENST00000317552.4	-	2	710	c.310C>T	c.(310-312)Cgg>Tgg	p.R104W	MID1_ENST00000380785.1_Missense_Mutation_p.R104W|MID1_ENST00000380780.1_Missense_Mutation_p.R104W|MID1_ENST00000380782.2_Missense_Mutation_p.R104W|MID1_ENST00000380787.1_Missense_Mutation_p.R104W|MID1_ENST00000380779.1_Missense_Mutation_p.R104W|MID1_ENST00000453318.2_Missense_Mutation_p.R104W	NM_000381.3|NM_033289.1	NP_000372.1|NP_150631.1	O15344	TRI18_HUMAN	midline 1 (Opitz/BBB syndrome)	104					microtubule cytoskeleton organization|pattern specification process|positive regulation of stress-activated MAPK cascade	cytoplasm|microtubule|microtubule associated complex|spindle	ligase activity|ubiquitin protein ligase binding|zinc ion binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(9)|ovary(2)|pancreas(1)|skin(3)|upper_aerodigestive_tract(1)	26						TCAAAGGCCCGCTCCCGACGG	0.597000													4	125					0	0	1	0	0
KIAA1024	23251	broad.mit.edu	37	15	79748964	79748964	+	Missense_Mutation	SNP	C	C	T	rs141472919		TCGA-XF-A9SU-01A-31D-A391-08	TCGA-XF-A9SU-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76efb030-c8f7-41e9-bb9c-5884bdd4bb53	e21da535-cf34-435d-9095-3bc029172d3b	g.chr15:79748964C>T	ENST00000305428.3	+	2	550	c.475C>T	c.(475-477)Cgg>Tgg	p.R159W		NM_015206.2	NP_056021.1	Q9UPX6	K1024_HUMAN	KIAA1024	159						integral to membrane				central_nervous_system(2)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(13)|lung(23)|ovary(2)|pancreas(2)|prostate(1)	49						GTCCAAGTGCCGGAAGATGGA	0.567000													3	44					0	0	1	0	0
MRPL1	65008	broad.mit.edu	37	4	78830443	78830443	+	Missense_Mutation	SNP	A	A	C			TCGA-XF-A9SU-01A-31D-A391-08	TCGA-XF-A9SU-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76efb030-c8f7-41e9-bb9c-5884bdd4bb53	e21da535-cf34-435d-9095-3bc029172d3b	g.chr4:78830443A>C	ENST00000315567.8	+	7	1023	c.694A>C	c.(694-696)Aaa>Caa	p.K232Q	MRPL1_ENST00000506674.1_3'UTR	NM_020236.3	NP_064621.3	Q9BYD6	RM01_HUMAN	mitochondrial ribosomal protein L1	232							RNA binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(9)|prostate(1)	17						TGACATCCCCAAAATGCTTGA	0.308000													10	75					0	0	1	0	0
BCAR1	9564	broad.mit.edu	37	16	75269625	75269625	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-A9SU-01A-31D-A391-08	TCGA-XF-A9SU-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76efb030-c8f7-41e9-bb9c-5884bdd4bb53	e21da535-cf34-435d-9095-3bc029172d3b	g.chr16:75269625C>T	ENST00000546196.1	-	5	2737	c.1085G>A	c.(1084-1086)cGt>cAt	p.R362H	BCAR1_ENST00000535626.2_Missense_Mutation_p.R243H|BCAR1_ENST00000566982.1_5'UTR|BCAR1_ENST00000420641.3_Missense_Mutation_p.R409H|BCAR1_ENST00000418647.3_Missense_Mutation_p.R437H|BCAR1_ENST00000538440.2_Missense_Mutation_p.R391H|BCAR1_ENST00000393422.2_Missense_Mutation_p.R409H|BCAR1_ENST00000542031.2_Missense_Mutation_p.R389H|BCAR1_ENST00000162330.5_Missense_Mutation_p.R391H|BCAR1_ENST00000393420.6_Missense_Mutation_p.R409H			P56945	BCAR1_HUMAN	breast cancer anti-estrogen resistance 1	391	Substrate for kinases (By similarity).				actin filament organization|B cell receptor signaling pathway|blood coagulation|cell adhesion|cell division|cell migration|cell proliferation|epidermal growth factor receptor signaling pathway|G-protein coupled receptor protein signaling pathway|insulin receptor signaling pathway|integrin-mediated signaling pathway|nerve growth factor receptor signaling pathway|platelet-derived growth factor receptor signaling pathway|positive regulation of cell migration|regulation of apoptosis|regulation of cell growth|T cell receptor signaling pathway	cytosol|focal adhesion|membrane fraction|ruffle	protein kinase binding|protein phosphatase binding|SH3 domain binding|signal transducer activity			breast(2)|central_nervous_system(5)|endometrium(1)|kidney(6)|large_intestine(1)|liver(1)|lung(13)|ovary(1)|prostate(3)|upper_aerodigestive_tract(2)	35				BRCA - Breast invasive adenocarcinoma(221;0.169)		CACCCGTTCACGGGGCACATC	0.692000													7	15					0	0	1	0	0
PLXNA2	5362	broad.mit.edu	37	1	208234107	208234107	+	Missense_Mutation	SNP	A	A	G			TCGA-XF-A9SU-01A-31D-A391-08	TCGA-XF-A9SU-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76efb030-c8f7-41e9-bb9c-5884bdd4bb53	e21da535-cf34-435d-9095-3bc029172d3b	g.chr1:208234107A>G	ENST00000367033.3	-	13	3419	c.2662T>C	c.(2662-2664)Tcc>Ccc	p.S888P		NM_025179.3	NP_079455.3	O75051	PLXA2_HUMAN	plexin A2	888	IPT/TIG 1.				axon guidance	integral to membrane|intracellular|plasma membrane				NS(1)|breast(3)|central_nervous_system(5)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|liver(1)|lung(28)|ovary(3)|prostate(5)|skin(2)|upper_aerodigestive_tract(3)	80				OV - Ovarian serous cystadenocarcinoma(81;0.199)		GCGATCTCGGAGAAGTCCAGA	0.622000													3	41					0	0	1	0	0
NRG1	3084	broad.mit.edu	37	8	32617917	32617917	+	Missense_Mutation	SNP	A	A	T			TCGA-XF-A9SU-01A-31D-A391-08	TCGA-XF-A9SU-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76efb030-c8f7-41e9-bb9c-5884bdd4bb53	e21da535-cf34-435d-9095-3bc029172d3b	g.chr8:32617917A>T	ENST00000338921.4	+	12	1802	c.1285A>T	c.(1285-1287)Agt>Tgt	p.S429C	NRG1_ENST00000519301.1_Missense_Mutation_p.S371C|NRG1_ENST00000539990.1_Missense_Mutation_p.S264C|NRG1_ENST00000405005.3_Missense_Mutation_p.S421C|NRG1_ENST00000287845.5_Missense_Mutation_p.S392C|NRG1_ENST00000341377.5_3'UTR|NRG1_ENST00000521670.1_Missense_Mutation_p.S421C|NRG1_ENST00000287842.3_Missense_Mutation_p.S418C|NRG1_ENST00000523079.1_Missense_Mutation_p.S418C|NRG1_ENST00000356819.4_Missense_Mutation_p.S426C			Q02297	NRG1_HUMAN	neuregulin 1	421					activation of transmembrane receptor protein tyrosine kinase activity|anti-apoptosis|cardiac muscle cell differentiation|cell communication|cell proliferation|cellular protein complex disassembly|embryo development|mammary gland development|negative regulation of cardiac muscle cell apoptosis|negative regulation of secretion|negative regulation of transcription, DNA-dependent|nervous system development|neural crest cell development|Notch signaling pathway|positive regulation of cardiac muscle cell proliferation|positive regulation of cell adhesion|positive regulation of cell growth|positive regulation of striated muscle cell differentiation|regulation of protein heterodimerization activity|regulation of protein homodimerization activity|transmembrane receptor protein tyrosine kinase signaling pathway|ventricular cardiac muscle cell differentiation|wound healing	apical plasma membrane|extracellular region|extracellular space|integral to membrane|nucleus|plasma membrane	cytokine activity|ErbB-3 class receptor binding|growth factor activity|protein binding|protein tyrosine kinase activator activity|receptor tyrosine kinase binding|transcription cofactor activity|transmembrane receptor protein tyrosine kinase activator activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(18)|ovary(1)|prostate(1)|skin(1)	39		Breast(100;0.203)		KIRC - Kidney renal clear cell carcinoma(67;0.0768)|Kidney(114;0.0943)		CTCTCCTCATAGTGAAAGGTA	0.512000													4	105					0	0	1	0	0
FAM188A	80013	broad.mit.edu	37	10	15883574	15883574	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-A9SU-01A-31D-A391-08	TCGA-XF-A9SU-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76efb030-c8f7-41e9-bb9c-5884bdd4bb53	e21da535-cf34-435d-9095-3bc029172d3b	g.chr10:15883574C>T	ENST00000277632.3	-	4	480	c.260G>A	c.(259-261)tGt>tAt	p.C87Y	FAM188A_ENST00000477891.1_5'UTR	NM_024948.2	NP_079224.1	Q9H8M7	F188A_HUMAN	family with sequence similarity 188, member A	87					apoptosis	nucleus	calcium ion binding			breast(2)|endometrium(5)|kidney(2)|large_intestine(3)|lung(7)|ovary(1)|skin(2)	22						CAAGGTATGACAAAGGAGTTC	0.353000													3	44					0	0	1	0	0
SYTL2	54843	broad.mit.edu	37	11	85422191	85422191	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-A9SU-01A-31D-A391-08	TCGA-XF-A9SU-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76efb030-c8f7-41e9-bb9c-5884bdd4bb53	e21da535-cf34-435d-9095-3bc029172d3b	g.chr11:85422191G>A	ENST00000359152.5	-	5	4332	c.4333C>T	c.(4333-4335)Ctt>Ttt	p.L1445F	SYTL2_ENST00000389958.3_Missense_Mutation_p.L30F|SYTL2_ENST00000525423.1_Missense_Mutation_p.L921F|SYTL2_ENST00000525702.1_Missense_Mutation_p.L41F|SYTL2_ENST00000527523.1_Missense_Mutation_p.L567F|SYTL2_ENST00000529581.1_Missense_Mutation_p.L41F|SYTL2_ENST00000528231.1_Missense_Mutation_p.L599F|SYTL2_ENST00000524452.1_Intron|SYTL2_ENST00000316356.4_Missense_Mutation_p.L600F|SYTL2_ENST00000354566.3_Missense_Mutation_p.L937F|SYTL2_ENST00000533892.1_Intron|SYTL2_ENST00000389960.4_Intron	NM_206928.2	NP_996811.1	Q9HCH5	SYTL2_HUMAN	synaptotagmin-like 2	599					intracellular protein transport|vesicle docking involved in exocytosis	exocytic vesicle|extrinsic to plasma membrane|melanosome|membrane fraction	neurexin binding|phosphatidylinositol-4,5-bisphosphate binding|phosphatidylserine binding|Rab GTPase binding			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(22)|ovary(2)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	52		Acute lymphoblastic leukemia(157;4.19e-06)|all_hematologic(158;0.0033)		KIRC - Kidney renal clear cell carcinoma(183;0.202)|Kidney(183;0.237)		GAGCTGCTAAGATTGGTTAAA	0.448000													13	120					0	0	1	0	0
VCAN	1462	broad.mit.edu	37	5	82817330	82817330	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-A9SU-01A-31D-A391-08	TCGA-XF-A9SU-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76efb030-c8f7-41e9-bb9c-5884bdd4bb53	e21da535-cf34-435d-9095-3bc029172d3b	g.chr5:82817330G>A	ENST00000265077.3	+	7	3770	c.3205G>A	c.(3205-3207)Gat>Aat	p.D1069N	VCAN_ENST00000512590.2_Missense_Mutation_p.D1021N|VCAN_ENST00000343200.5_Intron|VCAN_ENST00000502527.2_Intron|VCAN_ENST00000342785.4_Missense_Mutation_p.D1069N	NM_004385.4	NP_004376.2	P13611	CSPG2_HUMAN	versican	1069	GAG-alpha (glucosaminoglycan attachment domain).				cell adhesion|cell recognition|glial cell migration	extracellular space|proteinaceous extracellular matrix	calcium ion binding|hyaluronic acid binding|sugar binding			NS(2)|biliary_tract(1)|breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(52)|lung(64)|ovary(8)|pancreas(3)|prostate(13)|skin(14)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(5)	190		Lung NSC(167;0.0216)|all_lung(232;0.0251)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;2.47e-41)|Epithelial(54;2.51e-34)|all cancers(79;5.19e-29)		ACAAGAGGGCGATGGATCAGC	0.463000													11	52					0	0	1	0	0
AMZ2P1	201283	broad.mit.edu	37	17	62968690	62968690	+	RNA	SNP	A	A	G	rs138671696	by1000genomes	TCGA-XF-A9SU-01A-31D-A391-08	TCGA-XF-A9SU-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76efb030-c8f7-41e9-bb9c-5884bdd4bb53	e21da535-cf34-435d-9095-3bc029172d3b	g.chr17:62968690A>G	ENST00000430983.1	-	0	1554					NR_026903.1																						AAAATTCCACAAGTCTCTTGG	0.373000													3	82					0	0	1	0	0
ATAD2	29028	broad.mit.edu	37	8	124381391	124381391	+	Missense_Mutation	SNP	T	T	C			TCGA-XF-A9SU-01A-31D-A391-08	TCGA-XF-A9SU-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76efb030-c8f7-41e9-bb9c-5884bdd4bb53	e21da535-cf34-435d-9095-3bc029172d3b	g.chr8:124381391T>C	ENST00000287394.5	-	8	1063	c.956A>G	c.(955-957)aAc>aGc	p.N319S	ATAD2_ENST00000534257.1_5'UTR|ATAD2_ENST00000521903.1_5'UTR	NM_014109.3	NP_054828.2	Q6PL18	ATAD2_HUMAN	ATPase family, AAA domain containing 2	319					regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrion|nucleus	ATP binding|ATPase activity			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(12)|lung(16)|ovary(3)|prostate(3)|skin(1)|urinary_tract(2)	48	Lung NSC(37;1.25e-09)|Ovarian(258;0.00838)		STAD - Stomach adenocarcinoma(47;0.00288)			ATAAAATATGTTGGGCTTTCT	0.333000													6	25					0	0	1	0	0
PCDHA1	56147	broad.mit.edu	37	5	140167909	140167909	+	Silent	SNP	G	G	A			TCGA-XF-A9SU-01A-31D-A391-08	TCGA-XF-A9SU-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76efb030-c8f7-41e9-bb9c-5884bdd4bb53	e21da535-cf34-435d-9095-3bc029172d3b	g.chr5:140167909G>A	ENST00000504120.2	+	1	2034	c.2034G>A	c.(2032-2034)gcG>gcA	p.A678A	PCDHA1_ENST00000378133.3_Silent_p.A678A|PCDHA1_ENST00000394633.3_Intron	NM_018900.2	NP_061723.1												p.A678A(2)		breast(3)|endometrium(3)|kidney(2)|large_intestine(13)|lung(34)|prostate(3)|skin(4)|upper_aerodigestive_tract(5)|urinary_tract(3)	70			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGCCAAAGGCGTCTTCGCGGG	0.662000													8	75					0	0	1	0	0
FILIP1	27145	broad.mit.edu	37	6	76022751	76022751	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-A9SU-01A-31D-A391-08	TCGA-XF-A9SU-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76efb030-c8f7-41e9-bb9c-5884bdd4bb53	e21da535-cf34-435d-9095-3bc029172d3b	g.chr6:76022751C>T	ENST00000393004.2	-	5	3018	c.2797G>A	c.(2797-2799)Gaa>Aaa	p.E933K	FILIP1_ENST00000498523.1_5'UTR|FILIP1_ENST00000370020.1_Missense_Mutation_p.E834K|FILIP1_ENST00000237172.7_Missense_Mutation_p.E933K			Q7Z7B0	FLIP1_HUMAN	filamin A interacting protein 1	933										breast(3)|central_nervous_system(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|liver(1)|lung(28)|ovary(1)|pancreas(1)|prostate(5)|skin(9)|upper_aerodigestive_tract(4)	80						AAAAATTCTTCAGATGTCGGG	0.443000													11	81					0	0	1	0	0
BCLAF1	9774	broad.mit.edu	37	6	136594243	136594243	+	Silent	SNP	C	C	T	rs142595249	byFrequency	TCGA-XF-A9SU-01A-31D-A391-08	TCGA-XF-A9SU-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76efb030-c8f7-41e9-bb9c-5884bdd4bb53	e21da535-cf34-435d-9095-3bc029172d3b	g.chr6:136594243C>T	ENST00000531224.1	-	7	2187	c.1935G>A	c.(1933-1935)cgG>cgA	p.R645R	BCLAF1_ENST00000527759.1_Silent_p.R643R|BCLAF1_ENST00000527536.1_Silent_p.R645R|BCLAF1_ENST00000530767.1_Silent_p.R472R|BCLAF1_ENST00000392348.2_Silent_p.R643R|BCLAF1_ENST00000353331.4_Silent_p.R643R	NM_001077441.1|NM_014739.2	NP_001070909.1|NP_055554.1	Q9NYF8	BCLF1_HUMAN	BCL2-associated transcription factor 1	645					induction of apoptosis|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding			haematopoietic_and_lymphoid_tissue(3)|large_intestine(4)|ovary(1)|skin(1)	9	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00226)|OV - Ovarian serous cystadenocarcinoma(155;0.00331)		GGCTCTTTTGCCGAGTACTAT	0.393000													4	194					0	0	1	0	0
NLRP5	126206	broad.mit.edu	37	19	56538441	56538441	+	Missense_Mutation	SNP	C	C	T	rs45627733	byFrequency	TCGA-XF-A9SU-01A-31D-A391-08	TCGA-XF-A9SU-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76efb030-c8f7-41e9-bb9c-5884bdd4bb53	e21da535-cf34-435d-9095-3bc029172d3b	g.chr19:56538441C>T	ENST00000390649.3	+	7	842	c.842C>T	c.(841-843)aCg>aTg	p.T281M		NM_153447.4	NP_703148.4	P59047	NALP5_HUMAN	NLR family, pyrin domain containing 5	281	NACHT.					mitochondrion|nucleolus	ATP binding	p.T281M(1)		breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|ovary(5)|skin(2)|stomach(4)|upper_aerodigestive_tract(2)	25		Colorectal(82;3.46e-05)|Ovarian(87;0.0481)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0326)		CGGCCTCGCACGGTGGTTCTG	0.552000													2	2					0	0	1	0	0
CADM2	253559	broad.mit.edu	37	3	85932471	85932471	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-A9SU-01A-31D-A391-08	TCGA-XF-A9SU-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76efb030-c8f7-41e9-bb9c-5884bdd4bb53	e21da535-cf34-435d-9095-3bc029172d3b	g.chr3:85932471G>A	ENST00000383699.3	+	4	896	c.269G>A	c.(268-270)cGc>cAc	p.R90H	CADM2_ENST00000407528.2_Missense_Mutation_p.R81H|CADM2_ENST00000405615.2_Missense_Mutation_p.R83H	NM_001167675.1|NM_001256504.1|NM_001256505.1	NP_001161147.1|NP_001243433.1|NP_001243434.1	Q8N3J6	CADM2_HUMAN	cell adhesion molecule 2	81	Ig-like V-type.				adherens junction organization|cell junction assembly	integral to membrane|plasma membrane				endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(9)|lung(15)|ovary(1)|prostate(1)|skin(4)	38		Lung NSC(201;0.0148)		LUSC - Lung squamous cell carcinoma(29;0.000815)|Lung(72;0.00304)|BRCA - Breast invasive adenocarcinoma(55;0.156)|Epithelial(33;0.157)		GAGCTGGTTCGCGCTTCCTGG	0.373000													18	60					0	0	1	0	0
ABCB4	5244	broad.mit.edu	37	7	87046671	87046671	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-A9SU-01A-31D-A391-08	TCGA-XF-A9SU-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76efb030-c8f7-41e9-bb9c-5884bdd4bb53	e21da535-cf34-435d-9095-3bc029172d3b	g.chr7:87046671C>T	ENST00000265723.4	-	21	2750	c.2639G>A	c.(2638-2640)gGa>gAa	p.G880E	ABCB4_ENST00000453593.1_Missense_Mutation_p.G880E|ABCB4_ENST00000358400.3_Missense_Mutation_p.G880E|ABCB4_ENST00000545634.1_Missense_Mutation_p.G880E|ABCB4_ENST00000359206.3_Missense_Mutation_p.G880E	NM_000443.3|NM_018849.2	NP_000434.1|NP_061337.1	P21439	MDR3_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 4	880	ABC transmembrane type-1 2.				cellular lipid metabolic process	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus|membrane fraction	ATP binding|xenobiotic-transporting ATPase activity			breast(5)|endometrium(7)|kidney(2)|large_intestine(15)|lung(32)|ovary(4)|pancreas(2)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	77	Esophageal squamous(14;0.0058)|all_lung(186;0.201)|Lung NSC(181;0.203)					TTTGGCATTTCCAGCCAACAA	0.343000													4	59					0	0	1	0	0
PCDHA1	56147	broad.mit.edu	37	5	140168077	140168077	+	Silent	SNP	G	G	A			TCGA-XF-A9SU-01A-31D-A391-08	TCGA-XF-A9SU-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76efb030-c8f7-41e9-bb9c-5884bdd4bb53	e21da535-cf34-435d-9095-3bc029172d3b	g.chr5:140168077G>A	ENST00000504120.2	+	1	2202	c.2202G>A	c.(2200-2202)ccG>ccA	p.P734P	PCDHA1_ENST00000378133.3_Silent_p.P734P|PCDHA1_ENST00000394633.3_Intron	NM_018900.2	NP_061723.1														breast(3)|endometrium(3)|kidney(2)|large_intestine(13)|lung(34)|prostate(3)|skin(4)|upper_aerodigestive_tract(5)|urinary_tract(3)	70			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGTATGTGCCGGGCAAGCCCA	0.667000													3	50					0	0	1	0	0
CSNK2A1	1457	broad.mit.edu	37	20	476409	476409	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-A9SU-01A-31D-A391-08	TCGA-XF-A9SU-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76efb030-c8f7-41e9-bb9c-5884bdd4bb53	e21da535-cf34-435d-9095-3bc029172d3b	g.chr20:476409C>G	ENST00000217244.3	-	8	839	c.464G>C	c.(463-465)aGa>aCa	p.R155T	CSNK2A1_ENST00000400227.3_Missense_Mutation_p.R155T|CSNK2A1_ENST00000349736.5_Missense_Mutation_p.R155T|CSNK2A1_ENST00000400217.2_Missense_Mutation_p.R19T	NM_177559.2	NP_808227.1	P68400	CSK21_HUMAN	casein kinase 2, alpha 1 polypeptide	155	Protein kinase.				axon guidance|Wnt receptor signaling pathway	cytosol|NuRD complex|plasma membrane|Sin3 complex	ATP binding|protein N-terminus binding|protein serine/threonine kinase activity			autonomic_ganglia(1)|central_nervous_system(2)|endometrium(1)|large_intestine(4)|lung(5)|ovary(1)|prostate(2)|urinary_tract(1)	17		Breast(17;0.231)	OV - Ovarian serous cystadenocarcinoma(29;0.0969)			CTTGACATCTCTGTGCATAAT	0.418000													20	83					0	0	1	0	0
DTWD2	285605	broad.mit.edu	37	5	118274979	118274979	+	Missense_Mutation	SNP	T	T	C			TCGA-XF-A9SU-01A-31D-A391-08	TCGA-XF-A9SU-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76efb030-c8f7-41e9-bb9c-5884bdd4bb53	e21da535-cf34-435d-9095-3bc029172d3b	g.chr5:118274979T>C	ENST00000304058.4	-	3	188	c.118A>G	c.(118-120)Aaa>Gaa	p.K40E	DTWD2_ENST00000515439.3_Intron|DTWD2_ENST00000510708.1_Missense_Mutation_p.K106E			Q8NBA8	DTWD2_HUMAN	DTW domain containing 2	106										breast(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(4)	13		all_epithelial(76;0.0982)|Prostate(80;0.121)		OV - Ovarian serous cystadenocarcinoma(64;0.000228)|Epithelial(69;0.000941)|all cancers(49;0.00939)		CGCAACACTTTGTTTTCCTTT	0.333000													9	53					0	0	1	0	0
ANKFN1	162282	broad.mit.edu	37	17	54428147	54428147	+	Missense_Mutation	SNP	C	C	T	rs141896298	byFrequency	TCGA-XF-A9SU-01A-31D-A391-08	TCGA-XF-A9SU-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76efb030-c8f7-41e9-bb9c-5884bdd4bb53	e21da535-cf34-435d-9095-3bc029172d3b	g.chr17:54428147C>T	ENST00000566473.2	+	4	218	c.218C>T	c.(217-219)aCg>aTg	p.T73M	ANKFN1_ENST00000318698.2_Missense_Mutation_p.T73M			Q8N957	ANKF1_HUMAN	ankyrin-repeat and fibronectin type III domain containing 1	73										NS(1)|breast(1)|cervix(2)|endometrium(4)|kidney(4)|large_intestine(11)|lung(27)|ovary(1)|prostate(1)|skin(1)	53						GTGAAAATGACGCAACAAATG	0.388000													4	98					0	0	1	0	0
FAR1	84188	broad.mit.edu	37	11	13743295	13743295	+	Silent	SNP	T	T	C			TCGA-XF-A9SU-01A-31D-A391-08	TCGA-XF-A9SU-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76efb030-c8f7-41e9-bb9c-5884bdd4bb53	e21da535-cf34-435d-9095-3bc029172d3b	g.chr11:13743295T>C	ENST00000532502.1	+	1	1846	c.18T>C	c.(16-18)acT>acC	p.T6T	FAR1_ENST00000354817.3_Silent_p.T382T			Q8WVX9	FACR1_HUMAN	fatty acyl CoA reductase 1	382					ether lipid biosynthetic process	integral to membrane|peroxisomal matrix|peroxisomal membrane	protein binding			breast(1)|endometrium(1)|kidney(3)|large_intestine(1)|liver(1)|lung(3)|ovary(1)|prostate(1)|skin(1)	13						AAACAATAACTCGTCTTCACA	0.343000													11	31					0	0	1	0	0
ZNF560	147741	broad.mit.edu	37	19	9577542	9577542	+	Missense_Mutation	SNP	C	C	T	rs148650284		TCGA-XF-A9SU-01A-31D-A391-08	TCGA-XF-A9SU-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76efb030-c8f7-41e9-bb9c-5884bdd4bb53	e21da535-cf34-435d-9095-3bc029172d3b	g.chr19:9577542C>T	ENST00000301480.4	-	10	2294	c.2081G>A	c.(2080-2082)cGa>cAa	p.R694Q		NM_152476.2	NP_689689.2	Q96MR9	ZN560_HUMAN	zinc finger protein 560	694					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.R694Q(1)		NS(1)|breast(3)|endometrium(3)|kidney(2)|large_intestine(16)|liver(2)|lung(24)|ovary(2)|pancreas(1)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(4)	65						CATGGAATTTCGAAAGGAATT	0.378000													9	131					0	0	1	0	0
DUSP13	51207	broad.mit.edu	37	10	76857615	76857615	+	Missense_Mutation	SNP	G	G	A	rs138543174	byFrequency	TCGA-XF-A9SU-01A-31D-A391-08	TCGA-XF-A9SU-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76efb030-c8f7-41e9-bb9c-5884bdd4bb53	e21da535-cf34-435d-9095-3bc029172d3b	g.chr10:76857615G>A	ENST00000491677.2	-	6	957	c.415C>T	c.(415-417)Cgg>Tgg	p.R139W	DUSP13_ENST00000607131.1_Missense_Mutation_p.R103W|DUSP13_ENST00000607009.1_5'UTR|DUSP13_ENST00000372702.3_3'UTR|DUSP13_ENST00000478873.2_Missense_Mutation_p.R146W|DUSP13_ENST00000464872.1_Missense_Mutation_p.R10W|DUSP13_ENST00000472493.2_Missense_Mutation_p.R10W|DUSP13_ENST00000372700.3_Missense_Mutation_p.R60W|DUSP13_ENST00000605915.1_Missense_Mutation_p.R32W	NM_001007271.1	NP_001007272.1	Q6B8I1	MDSP_HUMAN	dual specificity phosphatase 13	0	Tyrosine-protein phosphatase.					cytoplasm	protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			large_intestine(3)|lung(3)|prostate(1)|urinary_tract(1)	8	all_cancers(46;0.0207)|all_epithelial(25;0.00126)|Prostate(51;0.0112)|Ovarian(15;0.0348)					TTGGGCCTCCGGAGGTCCTGC	0.642000													5	25					0	0	1	0	0
TTBK1	84630	broad.mit.edu	37	6	43250570	43250570	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-A9SU-01A-31D-A391-08	TCGA-XF-A9SU-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76efb030-c8f7-41e9-bb9c-5884bdd4bb53	e21da535-cf34-435d-9095-3bc029172d3b	g.chr6:43250570C>T	ENST00000259750.4	+	14	2175	c.2092C>T	c.(2092-2094)Cgg>Tgg	p.R698W		NM_032538.1	NP_115927.1	Q5TCY1	TTBK1_HUMAN	tau tubulin kinase 1	698						cell junction|cytoplasm|nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			breast(2)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(10)|liver(1)|lung(21)|ovary(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	53			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0125)|OV - Ovarian serous cystadenocarcinoma(102;0.0399)			TTACCGAGAACGGGCGCGGTT	0.622000													23	66					0	0	1	0	0
CTSL	1514	broad.mit.edu	37	9	90345407	90345407	+	Missense_Mutation	SNP	A	A	G			TCGA-XF-A9SU-01A-31D-A391-08	TCGA-XF-A9SU-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76efb030-c8f7-41e9-bb9c-5884bdd4bb53	e21da535-cf34-435d-9095-3bc029172d3b	g.chr9:90345407A>G	ENST00000343150.5	+	7	1786	c.896A>G	c.(895-897)aAg>aGg	p.K299R	CTSL_ENST00000495822.1_3'UTR|CTSL_ENST00000340342.6_Missense_Mutation_p.K299R					cathepsin L																		TGGCTGGTGAAGAACAGGTAT	0.393000													18	23					0	0	1	0	0
VWA3B	200403	broad.mit.edu	37	2	98920178	98920178	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-A9SU-01A-31D-A391-08	TCGA-XF-A9SU-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76efb030-c8f7-41e9-bb9c-5884bdd4bb53	e21da535-cf34-435d-9095-3bc029172d3b	g.chr2:98920178G>A	ENST00000477737.1	+	26	3638	c.3434G>A	c.(3433-3435)cGg>cAg	p.R1145Q	VWA3B_ENST00000490947.2_3'UTR	NM_144992.4	NP_659429.4	Q502W6	VWA3B_HUMAN	von Willebrand factor A domain containing 3B	1145										NS(3)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(10)|lung(33)|ovary(3)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	70						TTTTGCCCTCGGAGTGCACTT	0.383000													3	64					0	0	1	0	0
SLC9A7P1	121456	broad.mit.edu	37	12	98849029	98849029	+	RNA	SNP	G	G	T			TCGA-XF-A9SU-01A-31D-A391-08	TCGA-XF-A9SU-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76efb030-c8f7-41e9-bb9c-5884bdd4bb53	e21da535-cf34-435d-9095-3bc029172d3b	g.chr12:98849029G>T	ENST00000554295.1	-	0	1894					NR_033801.1																						GGGAGCCGCTGTGTCTCCACC	0.592000													4	10					1.58986e-06	1.70763e-06	1	1	0
HYAL4	23553	broad.mit.edu	37	7	123508588	123508588	+	Silent	SNP	C	C	T			TCGA-XF-A9SU-01A-31D-A391-08	TCGA-XF-A9SU-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76efb030-c8f7-41e9-bb9c-5884bdd4bb53	e21da535-cf34-435d-9095-3bc029172d3b	g.chr7:123508588C>T	ENST00000223026.4	+	3	899	c.261C>T	c.(259-261)gtC>gtT	p.V87V	HYAL4_ENST00000476325.1_Silent_p.V87V	NM_012269.2	NP_036401.2	Q2M3T9	HYAL4_HUMAN	hyaluronoglucosaminidase 4	87					fusion of sperm to egg plasma membrane|glycosaminoglycan catabolic process	integral to membrane	hyalurononglucosaminidase activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(8)|ovary(1)|skin(2)|upper_aerodigestive_tract(2)	23						GGCAAAATGTCACTATATTTT	0.398000													4	64					0	0	1	0	0
ASIC1	41	broad.mit.edu	37	12	50475346	50475346	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-A9SU-01A-31D-A391-08	TCGA-XF-A9SU-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76efb030-c8f7-41e9-bb9c-5884bdd4bb53	e21da535-cf34-435d-9095-3bc029172d3b	g.chr12:50475346C>T	ENST00000228468.4	+	12	2024	c.1639C>T	c.(1639-1641)Cgg>Tgg	p.R547W	ASIC1_ENST00000552438.1_Missense_Mutation_p.R535W|ASIC1_ENST00000447966.2_Missense_Mutation_p.R501W	NM_020039.3	NP_064423.2	P78348	ACCN2_HUMAN	acid-sensing (proton-gated) ion channel 1	501					calcium ion transport|response to pH|signal transduction	integral to plasma membrane	ligand-gated sodium channel activity|protein binding									Amiloride(DB00594)	CGAGAGCCTTCGGGGCCACCC	0.652000													8	31					0	0	1	0	0
SLC9A7P1	121456	broad.mit.edu	37	12	98849044	98849044	+	RNA	SNP	G	G	A			TCGA-XF-A9SU-01A-31D-A391-08	TCGA-XF-A9SU-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76efb030-c8f7-41e9-bb9c-5884bdd4bb53	e21da535-cf34-435d-9095-3bc029172d3b	g.chr12:98849044G>A	ENST00000554295.1	-	0	1879					NR_033801.1													p.P285L(1)									TCCACCAGGCGGGAGAGTGGT	0.607000													8	7					0	0	1	0	0
LPPR5	163404	broad.mit.edu	37	1	99387595	99387595	+	Missense_Mutation	SNP	A	A	G			TCGA-XF-A9SU-01A-31D-A391-08	TCGA-XF-A9SU-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76efb030-c8f7-41e9-bb9c-5884bdd4bb53	e21da535-cf34-435d-9095-3bc029172d3b	g.chr1:99387595A>G	ENST00000370188.3	-	4	1001	c.641T>C	c.(640-642)aTc>aCc	p.I214T	LPPR5_ENST00000263177.4_Missense_Mutation_p.I214T	NM_001010861.2	NP_001010861.1	Q32ZL2	LPPR5_HUMAN		214						integral to membrane	hydrolase activity										CTTGGCTTTGATTGTGTTGGT	0.353000													9	89					0	0	1	0	0
COL4A1	1282	broad.mit.edu	37	13	110862335	110862335	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-A9SU-01A-31D-A391-08	TCGA-XF-A9SU-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76efb030-c8f7-41e9-bb9c-5884bdd4bb53	e21da535-cf34-435d-9095-3bc029172d3b	g.chr13:110862335C>T	ENST00000375820.4	-	10	728	c.607G>A	c.(607-609)Gga>Aga	p.G203R	COL4A1_ENST00000543140.1_Missense_Mutation_p.G203R	NM_001845.4	NP_001836.2	P02462	CO4A1_HUMAN	collagen, type IV, alpha 1	203	Triple-helical region.				angiogenesis|axon guidance		extracellular matrix structural constituent|platelet-derived growth factor binding			breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(57)|ovary(4)|pancreas(1)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	105	all_cancers(4;9.8e-13)|all_epithelial(4;9.66e-08)|all_lung(23;3.75e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00178)|all_neural(89;0.00459)|Medulloblastoma(90;0.00596)|Lung SC(71;0.0604)	Breast(118;0.2)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.145)			ACTGGTGGTCCGGTAAATCCT	0.438000													4	26					0	0	1	0	0
SACS	26278	broad.mit.edu	37	13	23906197	23906197	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-A9SU-01A-31D-A391-08	TCGA-XF-A9SU-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76efb030-c8f7-41e9-bb9c-5884bdd4bb53	e21da535-cf34-435d-9095-3bc029172d3b	g.chr13:23906197C>T	ENST00000382298.3	-	10	12406	c.11818G>A	c.(11818-11820)Gtg>Atg	p.V3940M	SACS_ENST00000382292.3_Missense_Mutation_p.V3940M|SACS_ENST00000402364.1_Missense_Mutation_p.V3190M	NM_014363.4	NP_055178.3	Q9NZJ4	SACS_HUMAN	spastic ataxia of Charlevoix-Saguenay (sacsin)	3940					cell death|negative regulation of inclusion body assembly|protein folding	axon|cell body fiber|dendrite|mitochondrion|nucleus	ATP binding|chaperone binding|Hsp70 protein binding|proteasome binding			NS(1)|biliary_tract(1)|breast(3)|central_nervous_system(2)|endometrium(22)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(54)|lung(49)|ovary(7)|pancreas(1)|prostate(4)|skin(10)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(11)	189		all_cancers(29;1.51e-22)|all_epithelial(30;7.82e-19)|all_lung(29;4.71e-18)|Lung SC(185;0.0225)|Breast(139;0.128)		all cancers(112;0.00197)|Epithelial(112;0.00854)|OV - Ovarian serous cystadenocarcinoma(117;0.0298)|Lung(94;0.189)		AACATTTGCACACCAATATTC	0.413000													26	108					0	0	1	0	0
HSD3B2	3284	broad.mit.edu	37	1	119965138	119965138	+	Silent	SNP	G	G	A	rs116342586	by1000genomes	TCGA-XF-A9SU-01A-31D-A391-08	TCGA-XF-A9SU-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76efb030-c8f7-41e9-bb9c-5884bdd4bb53	e21da535-cf34-435d-9095-3bc029172d3b	g.chr1:119965138G>A	ENST00000543831.1	+	4	1263	c.1014G>A	c.(1012-1014)gcG>gcA	p.A338A	HSD3B2_ENST00000369416.3_Silent_p.A338A	NM_001166120.1	NP_001159592.1	P26439	3BHS2_HUMAN	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2	338					androgen biosynthetic process|glucocorticoid biosynthetic process|mineralocorticoid biosynthetic process	integral to membrane|microsome|mitochondrial inner membrane|mitochondrial intermembrane space|smooth endoplasmic reticulum membrane	3-beta-hydroxy-delta5-steroid dehydrogenase activity|binding|steroid delta-isomerase activity	p.A338A(1)		breast(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(19)|ovary(2)|skin(1)	27	all_neural(166;0.187)	all_lung(203;1.06e-06)|Lung NSC(69;7.5e-06)|all_epithelial(167;0.000284)		Lung(183;0.015)|LUSC - Lung squamous cell carcinoma(189;0.0836)	NADH(DB00157)|Trilostane(DB01108)	GAGATCTGGCGTATAAGCCAC	0.517000													9	52					0	0	1	0	0
PCDHB3	56132	broad.mit.edu	37	5	140481456	140481456	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-A9SU-01A-31D-A391-08	TCGA-XF-A9SU-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76efb030-c8f7-41e9-bb9c-5884bdd4bb53	e21da535-cf34-435d-9095-3bc029172d3b	g.chr5:140481456C>T	ENST00000231130.2	+	1	1223	c.1223C>T	c.(1222-1224)gCg>gTg	p.A408V	AC005754.7_ENST00000607216.1_RNA	NM_018937.2	NP_061760.1	Q9Y5E6	PCDB3_HUMAN		408	Cadherin 4.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			NS(2)|breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(19)|lung(24)|ovary(1)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	72			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TCAGAAGGCGCGCTGGACAGA	0.483000													14	77					0	0	1	0	0
MAGEB6	158809	broad.mit.edu	37	X	26212316	26212316	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-A9SU-01A-31D-A391-08	TCGA-XF-A9SU-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76efb030-c8f7-41e9-bb9c-5884bdd4bb53	e21da535-cf34-435d-9095-3bc029172d3b	g.chrX:26212316G>A	ENST00000379034.1	+	2	502	c.353G>A	c.(352-354)gGt>gAt	p.G118D		NM_173523.2	NP_775794.2	Q8N7X4	MAGB6_HUMAN	melanoma antigen family B, 6	118	Ser-rich.									breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|liver(1)|lung(18)|ovary(3)|prostate(2)	33						CCTGATGCAGGTGTTTCAGGC	0.547000													9	132					0	0	1	0	0
EFCAB6	64800	broad.mit.edu	37	22	44022419	44022419	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-A9SU-01A-31D-A391-08	TCGA-XF-A9SU-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76efb030-c8f7-41e9-bb9c-5884bdd4bb53	e21da535-cf34-435d-9095-3bc029172d3b	g.chr22:44022419C>G	ENST00000262726.7	-	20	2626	c.2373G>C	c.(2371-2373)ttG>ttC	p.L791F	EFCAB6_ENST00000396231.2_Missense_Mutation_p.L639F	NM_022785.3	NP_073622.2	Q5THR3	EFCB6_HUMAN	EF-hand calcium binding domain 6	791					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	calcium ion binding			breast(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(16)|lung(25)|ovary(4)|pancreas(1)|prostate(4)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	68		Ovarian(80;0.0247)|all_neural(38;0.025)				CACTAAGTCTCAAGCCAAGAA	0.428000													11	65					0	0	1	0	0
SSH1	54434	broad.mit.edu	37	12	109182728	109182728	+	Missense_Mutation	SNP	C	C	A			TCGA-XF-A9SU-01A-31D-A391-08	TCGA-XF-A9SU-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76efb030-c8f7-41e9-bb9c-5884bdd4bb53	e21da535-cf34-435d-9095-3bc029172d3b	g.chr12:109182728C>A	ENST00000326495.5	-	15	2279	c.2186G>T	c.(2185-2187)gGg>gTg	p.G729V	SSH1_ENST00000360239.3_Missense_Mutation_p.G417V	NM_018984.3	NP_061857.3	Q8WYL5	SSH1_HUMAN	slingshot protein phosphatase 1	729					actin cytoskeleton organization|cell morphogenesis|cellular response to ATP|regulation of actin polymerization or depolymerization|regulation of axonogenesis|regulation of cellular protein metabolic process|regulation of lamellipodium assembly	cleavage furrow|cytoplasm|cytoskeleton|lamellipodium|midbody|plasma membrane	actin binding|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			breast(1)|endometrium(5)|kidney(3)|large_intestine(9)|lung(8)|ovary(4)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	38						AGCTCCAGCCCCAGGGCCACT	0.607000													5	74					5.9392e-07	6.45888e-07	1	1	0
KIF1A	547	broad.mit.edu	37	2	241712572	241712572	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-A9SU-01A-31D-A391-08	TCGA-XF-A9SU-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76efb030-c8f7-41e9-bb9c-5884bdd4bb53	e21da535-cf34-435d-9095-3bc029172d3b	g.chr2:241712572C>T	ENST00000498729.2	-	13	1385	c.1139G>A	c.(1138-1140)cGg>cAg	p.R380Q	KIF1A_ENST00000320389.7_Missense_Mutation_p.R380Q	NM_001244008.1	NP_001230937.1	Q12756	KIF1A_HUMAN	kinesin family member 1A	380					anterograde axon cargo transport	cytoplasm|microtubule|nucleus	ATP binding|microtubule motor activity			NS(1)|central_nervous_system(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(8)|lung(25)|ovary(1)|prostate(5)|skin(2)|urinary_tract(1)	66		all_epithelial(40;1.35e-15)|Breast(86;2.14e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0295)|all_neural(83;0.0459)|Lung NSC(271;0.0942)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;6.12e-30)|all cancers(36;3.46e-27)|OV - Ovarian serous cystadenocarcinoma(60;1.38e-14)|Kidney(56;5e-09)|KIRC - Kidney renal clear cell carcinoma(57;5e-08)|BRCA - Breast invasive adenocarcinoma(100;5.87e-06)|Lung(119;0.00209)|LUSC - Lung squamous cell carcinoma(224;0.00902)|Colorectal(34;0.0282)|COAD - Colon adenocarcinoma(134;0.176)		CAGAAGGTCCCGCAGCCGGGT	0.612000													6	22					0	0	1	0	0
SLC9A7P1	121456	broad.mit.edu	37	12	98849035	98849035	+	RNA	SNP	C	C	A			TCGA-XF-A9SU-01A-31D-A391-08	TCGA-XF-A9SU-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76efb030-c8f7-41e9-bb9c-5884bdd4bb53	e21da535-cf34-435d-9095-3bc029172d3b	g.chr12:98849035C>A	ENST00000554295.1	-	0	1888					NR_033801.1																						CGCTGTGTCTCCACCAGGCGG	0.597000													5	6					6.40141e-05	6.79174e-05	1	1	0
DISP1	84976	broad.mit.edu	37	1	223165393	223165393	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-A9SU-01A-31D-A391-08	TCGA-XF-A9SU-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76efb030-c8f7-41e9-bb9c-5884bdd4bb53	e21da535-cf34-435d-9095-3bc029172d3b	g.chr1:223165393G>C	ENST00000284476.6	+	6	994	c.830G>C	c.(829-831)aGa>aCa	p.R277T	DISP1_ENST00000495684.1_3'UTR	NM_032890.3	NP_116279.2	Q96F81	DISP1_HUMAN	dispatched homolog 1 (Drosophila)	277					diaphragm development|protein homotrimerization|regulation of protein secretion|smoothened signaling pathway	basolateral plasma membrane|integral to membrane	hedgehog receptor activity|peptide transporter activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(3)|large_intestine(20)|lung(25)|prostate(4)|skin(1)|stomach(1)|urinary_tract(5)	69				GBM - Glioblastoma multiforme(131;0.102)		CATTATGAAAGAGAGAAAAGA	0.398000													3	49					0	0	1	0	0
HERC1	8925	broad.mit.edu	37	15	63920954	63920954	+	Missense_Mutation	SNP	T	T	C			TCGA-XF-A9SU-01A-31D-A391-08	TCGA-XF-A9SU-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76efb030-c8f7-41e9-bb9c-5884bdd4bb53	e21da535-cf34-435d-9095-3bc029172d3b	g.chr15:63920954T>C	ENST00000443617.2	-	70	13114	c.13027A>G	c.(13027-13029)Aaa>Gaa	p.K4343E		NM_003922.3	NP_003913.3	Q15751	HERC1_HUMAN	HECT and RLD domain containing E3 ubiquitin protein ligase family member 1	4343					protein modification process|transport	cytosol|Golgi apparatus|membrane	acid-amino acid ligase activity|ARF guanyl-nucleotide exchange factor activity			NS(3)|breast(9)|central_nervous_system(4)|endometrium(23)|haematopoietic_and_lymphoid_tissue(1)|kidney(12)|large_intestine(22)|liver(1)|lung(36)|ovary(7)|prostate(4)|skin(3)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	132						CGAACATTTTTCCCTTGCAGA	0.493000													6	57					0	0	1	0	0
ACAD10	80724	broad.mit.edu	37	12	112182675	112182675	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-A9SU-01A-31D-A391-08	TCGA-XF-A9SU-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76efb030-c8f7-41e9-bb9c-5884bdd4bb53	e21da535-cf34-435d-9095-3bc029172d3b	g.chr12:112182675C>T	ENST00000455480.2	+	14	2213	c.2036C>T	c.(2035-2037)tCa>tTa	p.S679L	ACAD10_ENST00000413681.3_3'UTR|ACAD10_ENST00000549590.1_Missense_Mutation_p.S648L|ACAD10_ENST00000313698.4_Missense_Mutation_p.S648L|ACAD10_ENST00000392636.2_Missense_Mutation_p.S250L	NM_001136538.1	NP_001130010.1	Q6JQN1	ACD10_HUMAN	acyl-CoA dehydrogenase family, member 10	648							acyl-CoA dehydrogenase activity|flavin adenine dinucleotide binding|hydrolase activity|transferase activity, transferring phosphorus-containing groups			NS(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(5)|liver(1)|lung(17)|ovary(4)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(5)	47						GCTCATACCTCAAGGGGAGGT	0.582000													25	73					0	0	1	0	0
MSL2	55167	broad.mit.edu	37	3	135871463	135871463	+	Missense_Mutation	SNP	T	T	C			TCGA-XF-A9SU-01A-31D-A391-08	TCGA-XF-A9SU-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76efb030-c8f7-41e9-bb9c-5884bdd4bb53	e21da535-cf34-435d-9095-3bc029172d3b	g.chr3:135871463T>C	ENST00000309993.2	-	2	992	c.260A>G	c.(259-261)tAt>tGt	p.Y87C	MSL2_ENST00000434835.2_Missense_Mutation_p.Y13C	NM_018133.3	NP_060603.2	Q9HCI7	MSL2_HUMAN	male-specific lethal 2 homolog (Drosophila)	87					histone H4-K16 acetylation	MSL complex	zinc ion binding			breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(6)|lung(5)|prostate(1)|skin(2)|urinary_tract(1)	18						AAACTGCTCATAGTCTTTGCA	0.413000													56	146					0	0	1	0	0
NRAP	4892	broad.mit.edu	37	10	115413821	115413821	+	Missense_Mutation	SNP	C	C	T	rs141144397		TCGA-XF-A9SU-01A-31D-A391-08	TCGA-XF-A9SU-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76efb030-c8f7-41e9-bb9c-5884bdd4bb53	e21da535-cf34-435d-9095-3bc029172d3b	g.chr10:115413821C>T	ENST00000369358.4	-	5	668	c.424G>A	c.(424-426)Gaa>Aaa	p.E142K	NRAP_ENST00000369360.3_Missense_Mutation_p.E142K|NRAP_ENST00000360478.3_Missense_Mutation_p.E142K|NRAP_ENST00000359988.3_Missense_Mutation_p.E142K			Q86VF7	NRAP_HUMAN	nebulin-related anchoring protein	142						fascia adherens|muscle tendon junction	actin binding|muscle alpha-actinin binding|zinc ion binding			autonomic_ganglia(1)|breast(2)|central_nervous_system(4)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(18)|lung(39)|ovary(6)|prostate(3)|skin(1)|stomach(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	95		Colorectal(252;0.0233)|Breast(234;0.188)		Epithelial(162;0.00392)|all cancers(201;0.00569)		CTTACAATTTCGGGGTCTGGC	0.458000													19	182					0	0	1	0	0
IQSEC3	440073	broad.mit.edu	37	12	274656	274656	+	Silent	SNP	A	A	G			TCGA-XF-A9SU-01A-31D-A391-08	TCGA-XF-A9SU-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76efb030-c8f7-41e9-bb9c-5884bdd4bb53	e21da535-cf34-435d-9095-3bc029172d3b	g.chr12:274656A>G	ENST00000538872.1	+	10	2884	c.2766A>G	c.(2764-2766)tcA>tcG	p.S922S	IQSEC3_ENST00000326261.4_Silent_p.S922S|RP11-598F7.5_ENST00000540136.1_RNA|IQSEC3_ENST00000382841.2_Silent_p.S619S			Q9UPP2	IQEC3_HUMAN	IQ motif and Sec7 domain 3	922	PH.				regulation of ARF protein signal transduction	cytoplasm	ARF guanyl-nucleotide exchange factor activity			central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(6)|lung(18)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	35	all_cancers(10;0.016)|all_lung(10;0.0222)|all_epithelial(11;0.0262)|Lung NSC(10;0.031)		OV - Ovarian serous cystadenocarcinoma(31;0.00456)	LUAD - Lung adenocarcinoma(1;0.172)|Lung(1;0.179)		TTTGCAAGTCAGTTGGCCTGC	0.478000													41	72					0	0	1	0	0
ZFYVE26	23503	broad.mit.edu	37	14	68260450	68260450	+	Silent	SNP	G	G	T			TCGA-XF-A9SU-01A-31D-A391-08	TCGA-XF-A9SU-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76efb030-c8f7-41e9-bb9c-5884bdd4bb53	e21da535-cf34-435d-9095-3bc029172d3b	g.chr14:68260450G>T	ENST00000347230.4	-	14	2566	c.2428C>A	c.(2428-2430)Cgg>Agg	p.R810R	ZFYVE26_ENST00000555452.1_Silent_p.R810R	NM_015346.3	NP_056161.2	Q68DK2	ZFY26_HUMAN	zinc finger, FYVE domain containing 26	810					cell cycle|cell death|cytokinesis|double-strand break repair via homologous recombination	centrosome|midbody	metal ion binding|phosphatidylinositol-3-phosphate binding|protein binding			NS(1)|breast(3)|cervix(1)|endometrium(6)|kidney(8)|large_intestine(8)|lung(39)|ovary(12)|pancreas(1)|prostate(7)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)	94				all cancers(60;0.000763)|OV - Ovarian serous cystadenocarcinoma(108;0.0011)|BRCA - Breast invasive adenocarcinoma(234;0.0115)		AGCTCATTCCGGCCAGACATG	0.527000													6	36					0.000157383	0.000164968	1	1	0
KRAS	3845	broad.mit.edu	37	12	25398284	25398284	+	Missense_Mutation	SNP	C	C	T	rs121913529		TCGA-XF-A9SU-01A-31D-A391-08	TCGA-XF-A9SU-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76efb030-c8f7-41e9-bb9c-5884bdd4bb53	e21da535-cf34-435d-9095-3bc029172d3b	g.chr12:25398284C>T	ENST00000311936.3	-	2	226	c.35G>A	c.(34-36)gGt>gAt	p.G12D	KRAS_ENST00000557334.1_Missense_Mutation_p.G12D|KRAS_ENST00000256078.4_Missense_Mutation_p.G12D|KRAS_ENST00000556131.1_Missense_Mutation_p.G12D	NM_004985.3	NP_004976.2	P01116	RASK_HUMAN	Kirsten rat sarcoma viral oncogene homolog	12			G -> A (in a colorectal cancer sample; somatic mutation).|G -> C (in lung carcinoma; somatic mutation).|G -> D (in pancreatic carcinoma, GASC and lung carcinoma; somatic mutation).|G -> R (in lung cancer and bladder cancer; somatic mutation).|G -> S (in lung carcinoma and GASC; somatic mutation).|G -> V (in lung carcinoma, pancreatic carcinoma, colon cancer and GASC; somatic mutation).		activation of MAPKK activity|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	plasma membrane	GTP binding|GTPase activity|protein binding	p.G12D(8562)|p.G12V(5775)|p.G12A(1407)|p.G12F(46)|p.G12L(8)|p.G12I(4)|p.G12E(3)|p.G12W(3)|p.G12Y(2)|p.G12fs*3(1)|p.G12C(1)|p.G12N(1)	UBE2L3/KRAS(2)	NS(6)|adrenal_gland(1)|autonomic_ganglia(3)|biliary_tract(532)|bone(2)|breast(32)|central_nervous_system(14)|cervix(50)|endometrium(411)|eye(4)|gastrointestinal_tract_(site_indeterminate)(7)|genital_tract(1)|haematopoietic_and_lymphoid_tissue(385)|kidney(8)|large_intestine(15267)|liver(29)|lung(3407)|oesophagus(16)|ovary(612)|pancreas(3739)|penis(1)|peritoneum(6)|prostate(96)|salivary_gland(6)|skin(45)|small_intestine(68)|soft_tissue(88)|stomach(207)|testis(17)|thymus(5)|thyroid(159)|upper_aerodigestive_tract(68)|urinary_tract(57)	25349	all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)		OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)			GCCTACGCCACCAGCTCCAAC	0.348000	G12A(KMS28BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(KPNSI9S_AUTONOMIC_GANGLIA)|G12A(MM1S_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(NCIH1573_LUNG)|G12A(NCIH2009_LUNG)|G12A(RERFLCAD1_LUNG)|G12A(RPMI8226_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(SW1116_LARGE_INTESTINE)|G12D(AGS_STOMACH)|G12D(ASPC1_PANCREAS)|G12D(COLO678_LARGE_INTESTINE)|G12D(HEC1A_ENDOMETRIUM)|G12D(HEC50B_ENDOMETRIUM)|G12D(HEYA8_OVARY)|G12D(HPAC_PANCREAS)|G12D(HPAFII_PANCREAS)|G12D(KARPAS620_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KP4_PANCREAS)|G12D(L33_PANCREAS)|G12D(LS180_LARGE_INTESTINE)|G12D(LS513_LARGE_INTESTINE)|G12D(MCAS_OVARY)|G12D(PANC0203_PANCREAS)|G12D(PANC0403_PANCREAS)|G12D(PANC0504_PANCREAS)|G12D(PANC0813_PANCREAS)|G12D(PANC1_PANCREAS)|G12D(PK1_PANCREAS)|G12D(PK59_PANCREAS)|G12D(SKLU1_LUNG)|G12D(SNUC2A_LARGE_INTESTINE)|G12D(SU8686_PANCREAS)|G12D(SUIT2_PANCREAS)|G12D(SW1990_PANCREAS)|G12V(A498_KIDNEY)|G12V(CAPAN2_PANCREAS)|G12V(CFPAC1_PANCREAS)|G12V(COLO668_LUNG)|G12V(CORL23_LUNG)|G12V(DANG_PANCREAS)|G12V(HCC56_LARGE_INTESTINE)|G12V(HUPT4_PANCREAS)|G12V(KP3_PANCREAS)|G12V(LCLC97TM1_LUNG)|G12V(NCIH2444_LUNG)|G12V(NCIH441_LUNG)|G12V(NCIH727_LUNG)|G12V(PANC0327_PANCREAS)|G12V(PATU8902_PANCREAS)|G12V(PATU8988S_PANCREAS)|G12V(QGP1_PANCREAS)|G12V(RCM1_LARGE_INTESTINE)|G12V(RERFLCAD2_LUNG)|G12V(RKN_OVARY)|G12V(SH10TC_STOMACH)|G12V(SHP77_LUNG)|G12V(SNGM_ENDOMETRIUM)|G12V(SW403_LARGE_INTESTINE)|G12V(SW480_LARGE_INTESTINE)|G12V(SW620_LARGE_INTESTINE)|G12V(SW900_LUNG)|G12V(YAPC_PANCREAS)	119	Mis		"""pancreatic, colorectal, lung, thyroid, AML, others"""				Noonan syndrome;Cardiofaciocutaneous syndrome	TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)			18	44					0	0	1	0	0
PDE4D	5144	broad.mit.edu	37	5	59284349	59284349	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-A9SU-01A-31D-A391-08	TCGA-XF-A9SU-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76efb030-c8f7-41e9-bb9c-5884bdd4bb53	e21da535-cf34-435d-9095-3bc029172d3b	g.chr5:59284349G>A	ENST00000502484.2	-	3	461	c.238C>T	c.(238-240)Ccg>Tcg	p.P80S	PDE4D_ENST00000546160.1_Missense_Mutation_p.P80S	NM_001165899.1	NP_001159371.1	Q08499	PDE4D_HUMAN	phosphodiesterase 4D, cAMP-specific	0	Pro-rich.				signal transduction	cytosol|insoluble fraction|membrane|microtubule organizing center|soluble fraction	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(8)|pancreas(1)	15		all_cancers(5;6.5e-58)|all_epithelial(5;1.75e-57)|all_lung(5;6.84e-18)|Lung NSC(5;1.29e-17)|Melanoma(5;0.00168)|Prostate(74;0.00234)|Colorectal(97;0.00629)|Ovarian(174;0.00832)|Breast(144;0.00996)|all_hematologic(6;0.0344)|Hepatocellular(6;0.0742)|Esophageal squamous(6;0.0954)		Epithelial(2;2.6e-55)|all cancers(2;2.66e-49)|OV - Ovarian serous cystadenocarcinoma(10;1.48e-39)|Colorectal(2;8.29e-08)|Lung(2;4.47e-07)|STAD - Stomach adenocarcinoma(2;1.11e-05)|COAD - Colon adenocarcinoma(2;0.00012)|LUSC - Lung squamous cell carcinoma(2;0.000775)|LUAD - Lung adenocarcinoma(3;0.0173)|READ - Rectum adenocarcinoma(2;0.0276)	Adenosine monophosphate(DB00131)|Dyphylline(DB00651)	GCAATCAGCGGCAGAATCTTC	0.468000													4	91					0	0	1	0	0
TYR	7299	broad.mit.edu	37	11	88961033	88961033	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-A9SU-01A-31D-A391-08	TCGA-XF-A9SU-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76efb030-c8f7-41e9-bb9c-5884bdd4bb53	e21da535-cf34-435d-9095-3bc029172d3b	g.chr11:88961033G>A	ENST00000263321.5	+	3	1581	c.1079G>A	c.(1078-1080)aGc>aAc	p.S360N		NM_000372.4	NP_000363.1	P14679	TYRO_HUMAN	tyrosinase	360					eye pigment biosynthetic process|melanin biosynthetic process from tyrosine|visual perception	Golgi-associated vesicle|integral to membrane|lysosome|melanosome membrane|perinuclear region of cytoplasm	copper ion binding|monophenol monooxygenase activity|protein heterodimerization activity|protein homodimerization activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(25)|ovary(2)|pancreas(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	48		Acute lymphoblastic leukemia(157;2.33e-05)|all_hematologic(158;0.0033)			Azelaic Acid(DB00548)|Mimosine(DB01055)|NADH(DB00157)	GCCTCTCAAAGCAGCATGCAC	0.388000													8	103					0	0	1	0	0
SZRD1	26099	broad.mit.edu	37	1	16719753	16719753	+	Silent	SNP	C	C	A			TCGA-XF-A9SU-01A-31D-A391-08	TCGA-XF-A9SU-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76efb030-c8f7-41e9-bb9c-5884bdd4bb53	e21da535-cf34-435d-9095-3bc029172d3b	g.chr1:16719753C>A	ENST00000401088.4	+	3	307	c.132C>A	c.(130-132)ccC>ccA	p.P44P	SZRD1_ENST00000375590.3_Silent_p.P24P|SZRD1_ENST00000471507.1_Silent_p.P43P|SZRD1_ENST00000472461.1_3'UTR|SZRD1_ENST00000492354.1_Silent_p.P24P|SZRD1_ENST00000401089.3_Silent_p.P25P	NM_001114600.1|NM_001271869.1	NP_001108072.1|NP_001258798.1			SUZ RNA binding domain containing 1																		CCAAAGTGCCCATTGTGATTC	0.567000													4	124					0.014758	0.0149296	1	1	0
MAGED2	10916	broad.mit.edu	37	X	54839984	54839984	+	Splice_Site	SNP	G	G	T			TCGA-XF-A9SU-01A-31D-A391-08	TCGA-XF-A9SU-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76efb030-c8f7-41e9-bb9c-5884bdd4bb53	e21da535-cf34-435d-9095-3bc029172d3b	g.chrX:54839984G>T	ENST00000375068.1	+	10	1504		c.e10+1		MAGED2_ENST00000375060.1_Splice_Site|MAGED2_ENST00000375062.4_Splice_Site|MAGED2_ENST00000347546.4_Splice_Site|MAGED2_ENST00000375058.1_Splice_Site|MAGED2_ENST00000375053.2_Splice_Site|MAGED2_ENST00000396224.1_Splice_Site|MAGED2_ENST00000218439.4_Splice_Site			Q9UNF1	MAGD2_HUMAN	melanoma antigen family D, 2											breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(8)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	26						TGAAGCAGAAGTAAGTATCTC	0.393000													12	73					2.27111e-07	2.5011e-07	1	1	0
PCSK2	5126	broad.mit.edu	37	20	17338981	17338981	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-A9SU-01A-31D-A391-08	TCGA-XF-A9SU-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76efb030-c8f7-41e9-bb9c-5884bdd4bb53	e21da535-cf34-435d-9095-3bc029172d3b	g.chr20:17338981G>A	ENST00000262545.2	+	3	607	c.292G>A	c.(292-294)Gct>Act	p.A98T	PCSK2_ENST00000377899.1_Missense_Mutation_p.A79T|PCSK2_ENST00000536609.1_Missense_Mutation_p.A63T	NM_002594.3	NP_002585.2	P16519	NEC2_HUMAN	proprotein convertase subtilisin/kexin type 2	98					enkephalin processing|insulin processing|islet amyloid polypeptide processing	extracellular space|membrane|soluble fraction|transport vesicle	serine-type endopeptidase activity			breast(2)|central_nervous_system(2)|endometrium(5)|kidney(5)|large_intestine(7)|lung(17)|ovary(3)|pancreas(2)|prostate(3)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	53					Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	GGTAAAGATGGCTTTGCAGCA	0.373000													6	23					0	0	1	0	0
LRRC31	79782	broad.mit.edu	37	3	169587505	169587505	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-A9SU-01A-31D-A391-08	TCGA-XF-A9SU-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76efb030-c8f7-41e9-bb9c-5884bdd4bb53	e21da535-cf34-435d-9095-3bc029172d3b	g.chr3:169587505C>T	ENST00000316428.5	-	1	148	c.91G>A	c.(91-93)Gaa>Aaa	p.E31K	LRRC31_ENST00000397805.2_5'UTR|LRRC31_ENST00000523069.1_Missense_Mutation_p.E31K|LRRC31_ENST00000264676.5_Missense_Mutation_p.E31K	NM_001277127.1|NM_024727.2	NP_001264056.1|NP_079003.2	Q6UY01	LRC31_HUMAN	leucine rich repeat containing 31	31										cervix(3)|endometrium(3)|large_intestine(8)|lung(9)|ovary(2)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	31	all_cancers(22;2.76e-22)|all_epithelial(15;4.73e-27)|all_lung(20;9.24e-17)|Lung NSC(18;3.85e-16)|Ovarian(172;0.000223)|Breast(254;0.197)		Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.00943)			TTTCTGCTTTCAGCATTGGAG	0.468000													24	55					0	0	1	0	0
DDX26B	203522	broad.mit.edu	37	X	134654980	134654980	+	Silent	SNP	C	C	T			TCGA-XF-A9SU-01A-31D-A391-08	TCGA-XF-A9SU-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76efb030-c8f7-41e9-bb9c-5884bdd4bb53	e21da535-cf34-435d-9095-3bc029172d3b	g.chrX:134654980C>T	ENST00000370752.4	+	1	397	c.63C>T	c.(61-63)ggC>ggT	p.G21G	DDX26B_ENST00000481908.1_3'UTR	NM_182540.4	NP_872346.3	Q5JSJ4	DX26B_HUMAN	DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 26B	21	VWFA.									large_intestine(1)|lung(8)	9	Acute lymphoblastic leukemia(192;6.56e-05)					CTGACCTGGGCACCTCTTATT	0.587000													32	125					0	0	1	0	0
ZNF628	89887	broad.mit.edu	37	19	55994305	55994305	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-A9SU-01A-31D-A391-08	TCGA-XF-A9SU-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76efb030-c8f7-41e9-bb9c-5884bdd4bb53	e21da535-cf34-435d-9095-3bc029172d3b	g.chr19:55994305G>A	ENST00000598519.1	+	3	2298	c.1745G>A	c.(1744-1746)cGg>cAg	p.R582Q	ZNF628_ENST00000391718.2_Missense_Mutation_p.R578Q			Q5EBL2	ZN628_HUMAN	zinc finger protein 628	578						nucleus	DNA binding|zinc ion binding			endometrium(4)|kidney(1)|lung(2)	7	Breast(117;0.155)		BRCA - Breast invasive adenocarcinoma(297;0.18)|LUSC - Lung squamous cell carcinoma(43;0.193)	GBM - Glioblastoma multiforme(193;0.0531)		TCCAACCTGCGGCAGCACCAG	0.701000													7	32					0	0	1	0	0
TNFSF13B	10673	broad.mit.edu	37	13	108922337	108922337	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-A9SU-01A-31D-A391-08	TCGA-XF-A9SU-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76efb030-c8f7-41e9-bb9c-5884bdd4bb53	e21da535-cf34-435d-9095-3bc029172d3b	g.chr13:108922337C>T	ENST00000375887.4	+	1	272	c.94C>T	c.(94-96)Cca>Tca	p.P32S	TNFSF13B_ENST00000430559.1_Missense_Mutation_p.P32S|TNFSF13B_ENST00000542136.1_Missense_Mutation_p.P32S	NM_006573.4	NP_006564.1	Q9Y275	TN13B_HUMAN	tumor necrosis factor (ligand) superfamily, member 13b	32					cell proliferation|immune response|signal transduction	extracellular space|integral to membrane|plasma membrane|soluble fraction	cytokine activity|tumor necrosis factor receptor binding			large_intestine(1)|lung(5)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	10	all_lung(23;0.000396)|all_neural(89;0.00256)|Medulloblastoma(90;0.00596)|Lung NSC(43;0.00902)|Lung SC(71;0.104)		all cancers(43;0.184)|BRCA - Breast invasive adenocarcinoma(86;0.19)			TTCCATCCTCCCACGGAAGGA	0.517000													26	147					0	0	1	0	0
PIK3C2B	5287	broad.mit.edu	37	1	204438093	204438093	+	Missense_Mutation	SNP	T	T	C			TCGA-XF-A9SU-01A-31D-A391-08	TCGA-XF-A9SU-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76efb030-c8f7-41e9-bb9c-5884bdd4bb53	e21da535-cf34-435d-9095-3bc029172d3b	g.chr1:204438093T>C	ENST00000367187.3	-	3	1394	c.838A>G	c.(838-840)Atg>Gtg	p.M280V	PIK3C2B_ENST00000424712.2_Missense_Mutation_p.M280V	NM_002646.3	NP_002637.3	O00750	P3C2B_HUMAN	phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta	280	Interaction with GRB2.				cell communication|phosphatidylinositol-mediated signaling	endoplasmic reticulum|microsome|nucleus|phosphatidylinositol 3-kinase complex|plasma membrane	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity|protein binding			breast(3)|central_nervous_system(1)|cervix(2)|endometrium(4)|large_intestine(11)|lung(24)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	52	all_cancers(21;0.00347)|all_neural(3;0.0218)|Glioma(3;0.0382)|all_epithelial(62;0.171)|Breast(84;0.179)|Prostate(682;0.227)		GBM - Glioblastoma multiforme(2;2.69e-45)|all cancers(3;1.66e-30)|KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.143)|Epithelial(59;0.193)			TGAGGGGGCATAGTCTTGCTC	0.642000													5	111					0	0	1	0	0
NCOA6	23054	broad.mit.edu	37	20	33345744	33345744	+	Silent	SNP	C	C	T			TCGA-XF-A9SU-01A-31D-A391-08	TCGA-XF-A9SU-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76efb030-c8f7-41e9-bb9c-5884bdd4bb53	e21da535-cf34-435d-9095-3bc029172d3b	g.chr20:33345744C>T	ENST00000374796.2	-	8	3377	c.807G>A	c.(805-807)caG>caA	p.Q269Q	NCOA6_ENST00000359003.2_Silent_p.Q269Q			Q14686	NCOA6_HUMAN	nuclear receptor coactivator 6	269	CREBBP-binding region.|Gln-rich.|NCOA1-binding region.|TBP/GTF2A-binding region.				brain development|cellular lipid metabolic process|DNA recombination|DNA repair|DNA replication|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|heart development|myeloid cell differentiation|positive regulation of transcription from RNA polymerase II promoter|response to hormone stimulus|transcription initiation from RNA polymerase II promoter	transcription factor complex	chromatin binding|enzyme binding|estrogen receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|retinoid X receptor binding|thyroid hormone receptor binding	p.Q269Q(15)		NS(2)|breast(6)|central_nervous_system(3)|cervix(1)|endometrium(9)|kidney(8)|large_intestine(16)|lung(37)|ovary(4)|prostate(5)|skin(13)|upper_aerodigestive_tract(2)|urinary_tract(1)	107						gctgctgctgctgttgttgtt	0.537000													3	42					0	0	1	0	0
C2orf43	60526	broad.mit.edu	37	2	20886812	20886812	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-A9SU-01A-31D-A391-08	TCGA-XF-A9SU-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76efb030-c8f7-41e9-bb9c-5884bdd4bb53	e21da535-cf34-435d-9095-3bc029172d3b	g.chr2:20886812C>G	ENST00000237822.3	-	7	908	c.829G>C	c.(829-831)Gag>Cag	p.E277Q	C2orf43_ENST00000440866.2_3'UTR|C2orf43_ENST00000403006.2_Missense_Mutation_p.E147Q|C2orf43_ENST00000541941.1_Missense_Mutation_p.E147Q|C2orf43_ENST00000381090.3_Missense_Mutation_p.E277Q|C2orf43_ENST00000435420.2_Missense_Mutation_p.E229Q	NM_001282721.1|NM_021925.2	NP_001269650.1|NP_068744.1	Q9H6V9	CB043_HUMAN	chromosome 2 open reading frame 43	277										endometrium(1)|kidney(1)|large_intestine(1)|lung(2)|stomach(1)	6	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TCATAGTACTCTTTTGGACAC	0.358000													11	50					0	0	1	0	0
ISYNA1	51477	broad.mit.edu	37	19	18546224	18546224	+	Missense_Mutation	SNP	A	A	G			TCGA-XF-A9SU-01A-31D-A391-08	TCGA-XF-A9SU-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76efb030-c8f7-41e9-bb9c-5884bdd4bb53	e21da535-cf34-435d-9095-3bc029172d3b	g.chr19:18546224A>G	ENST00000338128.8	-	10	1541	c.1324T>C	c.(1324-1326)Ttc>Ctc	p.F442L	ISYNA1_ENST00000578963.1_Missense_Mutation_p.F314L|ISYNA1_ENST00000457269.4_Missense_Mutation_p.F388L|ISYNA1_ENST00000317018.6_Missense_Mutation_p.F240L|ISYNA1_ENST00000545187.1_Missense_Mutation_p.F292L	NM_001170938.1|NM_016368.4	NP_001164409.1|NP_057452.1	Q9NPH2	INO1_HUMAN	inositol-3-phosphate synthase 1						inositol biosynthetic process|phospholipid biosynthetic process	cytoplasm	binding|inositol-3-phosphate synthase activity			breast(1)|endometrium(1)|kidney(2)|lung(4)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(2)	12						TCAGTGCAGAAGCTCACGCGC	0.687000													10	56					0	0	1	0	0
COBL	23242	broad.mit.edu	37	7	51092921	51092921	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-A9SU-01A-31D-A391-08	TCGA-XF-A9SU-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76efb030-c8f7-41e9-bb9c-5884bdd4bb53	e21da535-cf34-435d-9095-3bc029172d3b	g.chr7:51092921G>C	ENST00000395542.2	-	14	4083	c.3899C>G	c.(3898-3900)tCt>tGt	p.S1300C	COBL_ENST00000265136.7_Missense_Mutation_p.S1218C			O75128	COBL_HUMAN	cordon-bleu WH2 repeat protein	1218										NS(2)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(10)|lung(26)|ovary(3)|prostate(4)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	65	Glioma(55;0.08)					CCTTGGTGCAGAGAGAGCCTG	0.642000													5	22					0	0	1	0	0
DNAH17	8632	broad.mit.edu	37	17	76454681	76454681	+	Missense_Mutation	SNP	C	C	T	rs142069633		TCGA-XF-A9SU-01A-31D-A391-08	TCGA-XF-A9SU-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76efb030-c8f7-41e9-bb9c-5884bdd4bb53	e21da535-cf34-435d-9095-3bc029172d3b	g.chr17:76454681C>T	ENST00000389840.5	-	62	10025	c.9901G>A	c.(9901-9903)Gat>Aat	p.D3301N	DNAH17_ENST00000586052.1_5'UTR|DNAH17_ENST00000585328.1_Missense_Mutation_p.D3310N					dynein, axonemal, heavy chain 17											NS(2)|breast(7)|central_nervous_system(5)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(13)|large_intestine(8)|lung(37)|ovary(8)|prostate(7)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	116			BRCA - Breast invasive adenocarcinoma(99;0.00294)|OV - Ovarian serous cystadenocarcinoma(97;0.0656)			TTCGTGGCATCGGCCTCTTGC	0.522000													18	113					0	0	1	0	0
MIR521-2	574481	broad.mit.edu	37	19	54219875	54219875	+	RNA	SNP	G	G	T			TCGA-XF-A9SU-01A-31D-A391-08	TCGA-XF-A9SU-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76efb030-c8f7-41e9-bb9c-5884bdd4bb53	e21da535-cf34-435d-9095-3bc029172d3b	g.chr19:54219875G>T	ENST00000384818.1	+	0	28					NR_030203.1																						CCAAAGGGAAGAATTTTCTCT	0.403000													9	157					0.000274275	0.000284071	1	1	0
TRGC1	6966	broad.mit.edu	37	7	38301855	38301856	+	RNA	DEL	GT	GT	-			TCGA-XF-A9SU-01A-31D-A391-08	TCGA-XF-A9SU-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76efb030-c8f7-41e9-bb9c-5884bdd4bb53	e21da535-cf34-435d-9095-3bc029172d3b	g.chr7:38301855_38301856delGT	ENST00000443402.2	-	0	330					NM_001003799.1|NM_001003806.1	NP_001003799.1|NP_001003806.1																					TCAATTGTTCGTGTGTGTGTGT	0.356													7	111	---	---	---	---					
FAM135B	51059	broad.mit.edu	37	8	139180153	139180153	+	Frame_Shift_Del	DEL	C	C	-			TCGA-XF-A9SU-01A-31D-A391-08	TCGA-XF-A9SU-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76efb030-c8f7-41e9-bb9c-5884bdd4bb53	e21da535-cf34-435d-9095-3bc029172d3b	g.chr8:139180153delC	ENST00000395297.1	-	12	1413	c.1243delG	c.(1243-1245)gacfs	p.D415fs		NM_015912.3	NP_056996.2	Q49AJ0	F135B_HUMAN	family with sequence similarity 135, member B	415										NS(3)|breast(9)|endometrium(21)|kidney(5)|large_intestine(28)|liver(1)|lung(135)|ovary(9)|pancreas(1)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(1)	238	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			GCAGGGCAGTCCACGTATCTG	0.522										HNSCC(54;0.14)			8	108	---	---	---	---					
HRCT1	646962	broad.mit.edu	37	9	35906348	35906350	+	In_Frame_Del	DEL	CTG	CTG	-			TCGA-XF-A9SU-01A-31D-A391-08	TCGA-XF-A9SU-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76efb030-c8f7-41e9-bb9c-5884bdd4bb53	e21da535-cf34-435d-9095-3bc029172d3b	g.chr9:35906348_35906350delCTG	ENST00000354323.2	+	1	160_162	c.64_66delCTG	c.(64-66)ctgdel	p.L28del		NM_001039792.1	NP_001034881.1	Q6UXD1	HRCT1_HUMAN	histidine rich carboxyl terminus 1	28						integral to membrane				NS(1)|haematopoietic_and_lymphoid_tissue(1)|lung(1)|prostate(1)	4						TGTGGCGGTCctgctgctgctgc	0.670													8	13	---	---	---	---					
ZFP36L1	677	broad.mit.edu	37	14	69256543	69256544	+	Frame_Shift_Ins	INS	-	-	AG			TCGA-XF-A9SU-01A-31D-A391-08	TCGA-XF-A9SU-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76efb030-c8f7-41e9-bb9c-5884bdd4bb53	e21da535-cf34-435d-9095-3bc029172d3b	g.chr14:69256543_69256544insAG	ENST00000439696.2	-	2	1024_1025	c.723_724insCT	c.(721-726)cctaccfs	p.T242fs	ZFP36L1_ENST00000336440.3_Frame_Shift_Ins_p.T242fs|ZFP36L1_ENST00000555997.1_3'UTR	NM_001244701.1|NM_004926.3	NP_001231630.1|NP_004917.2	Q07352	TISB_HUMAN	ZFP36 ring finger protein-like 1	242					regulation of mRNA stability	cytosol|nucleus	DNA binding|mRNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.T242A(1)		breast(4)|kidney(1)|large_intestine(1)|liver(2)|lung(9)|ovary(1)|prostate(2)|urinary_tract(1)	21				all cancers(60;0.00203)|BRCA - Breast invasive adenocarcinoma(234;0.00205)|OV - Ovarian serous cystadenocarcinoma(108;0.0401)		TCGGGCAGGGTAGGTGAGCCCA	0.678											OREG0022753	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	13	136	---	---	---	---					
ZFP36L1	677	broad.mit.edu	37	14	69256926	69256927	+	Frame_Shift_Ins	INS	-	-	GGCT			TCGA-XF-A9SU-01A-31D-A391-08	TCGA-XF-A9SU-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76efb030-c8f7-41e9-bb9c-5884bdd4bb53	e21da535-cf34-435d-9095-3bc029172d3b	g.chr14:69256926_69256927insGGCT	ENST00000439696.2	-	2	641_642	c.340_341insAGCC	c.(340-342)cgcfs	p.R114fs	ZFP36L1_ENST00000336440.3_Frame_Shift_Ins_p.R114fs|ZFP36L1_ENST00000555997.1_3'UTR	NM_001244701.1|NM_004926.3	NP_001231630.1|NP_004917.2	Q07352	TISB_HUMAN	ZFP36 ring finger protein-like 1	114					regulation of mRNA stability	cytosol|nucleus	DNA binding|mRNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(4)|kidney(1)|large_intestine(1)|liver(2)|lung(9)|ovary(1)|prostate(2)|urinary_tract(1)	21				all cancers(60;0.00203)|BRCA - Breast invasive adenocarcinoma(234;0.00205)|OV - Ovarian serous cystadenocarcinoma(108;0.0401)		CGTCTTGTAGCGGCTGGAGTTG	0.668											OREG0022753	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	28	177	---	---	---	---					
HERC2P2	400322	broad.mit.edu	37	15	23331163	23331163	+	RNA	DEL	A	A	-			TCGA-XF-A9SU-01A-31D-A391-08	TCGA-XF-A9SU-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76efb030-c8f7-41e9-bb9c-5884bdd4bb53	e21da535-cf34-435d-9095-3bc029172d3b	g.chr15:23331163delA	ENST00000560464.1	-	0	908																											AATAAATACTAAAAAAAAAAA	0.368													4	6	---	---	---	---					
DNM1P47	100216544	broad.mit.edu	37	15	102299886	102299887	+	RNA	INS	-	-	G			TCGA-XF-A9SU-01A-31D-A391-08	TCGA-XF-A9SU-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76efb030-c8f7-41e9-bb9c-5884bdd4bb53	e21da535-cf34-435d-9095-3bc029172d3b	g.chr15:102299886_102299887insG	ENST00000561463.1	+	0	7932_7933																											AACCTGTACTCGCGTCGGAACC	0.589													5	10	---	---	---	---					
PKD1L2	114780	broad.mit.edu	37	16	81253526	81253527	+	RNA	INS	-	-	TTATT	rs140827348	by1000genomes	TCGA-XF-A9SU-01A-31D-A391-08	TCGA-XF-A9SU-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76efb030-c8f7-41e9-bb9c-5884bdd4bb53	e21da535-cf34-435d-9095-3bc029172d3b	g.chr16:81253526_81253527insTTATT	ENST00000337114.4	-	0	301				PKD1L2_ENST00000525539.1_RNA	NM_001076780.1	NP_001070248.1	Q7Z442	PK1L2_HUMAN	polycystic kidney disease 1-like 2						neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity|sugar binding			breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(20)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	44						ttagacatgaattatttaatcc	0.391													3	3	---	---	---	---					
TRMU	55687	broad.mit.edu	37	22	46742442	46742443	+	Splice_Site	INS	-	-	T			TCGA-XF-A9SU-01A-31D-A391-08	TCGA-XF-A9SU-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76efb030-c8f7-41e9-bb9c-5884bdd4bb53	e21da535-cf34-435d-9095-3bc029172d3b	g.chr22:46742442_46742443insT	ENST00000290846.4	+	4	818		c.e4+1		TRMU_ENST00000424260.2_Splice_Site|TRMU_ENST00000381019.3_Splice_Site	NM_018006.4	NP_060476.2	O75648	MTU1_HUMAN	tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase							mitochondrion	ATP binding|sulfurtransferase activity|tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity|tRNA binding			NS(2)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(2)|ovary(1)	10		Ovarian(80;0.00965)|Breast(42;0.0194)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00449)|LUAD - Lung adenocarcinoma(64;0.248)		GTTAGAAATGGTAAGTTCATGT	0.465													13	113	---	---	---	---