Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
ZSCAN21	7589	broad.mit.edu	37	7	99661434	99661434	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-AAN4-01A-11D-A42E-08	TCGA-XF-AAN4-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ef58d603-784f-406e-b97d-ab2ce298601d	a06ce9e1-7c84-4520-aa93-bedc1d91a0f6	g.chr7:99661434G>A	ENST00000292450.4	+	4	780	c.616G>A	c.(616-618)Gag>Aag	p.E206K	ZSCAN21_ENST00000543588.1_Missense_Mutation_p.E206K|ZSCAN21_ENST00000477297.1_Intron|ZSCAN21_ENST00000456748.2_Missense_Mutation_p.E206K	NM_145914.2	NP_666019.1	Q9Y5A6	ZSC21_HUMAN	zinc finger and SCAN domain containing 21	206					positive regulation of transcription, DNA-dependent|viral reproduction	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|central_nervous_system(3)|endometrium(2)|kidney(1)|large_intestine(2)|lung(8)|ovary(3)|skin(1)	21	Lung NSC(181;0.0211)|all_lung(186;0.0323)|Esophageal squamous(72;0.0439)		STAD - Stomach adenocarcinoma(171;0.129)			TACCCAGCACGAGGAATCAGC	0.428000													4	117					0	0	1	0	0
LRRK2	120892	broad.mit.edu	37	12	40657633	40657633	+	Missense_Mutation	SNP	A	A	G			TCGA-XF-AAN4-01A-11D-A42E-08	TCGA-XF-AAN4-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ef58d603-784f-406e-b97d-ab2ce298601d	a06ce9e1-7c84-4520-aa93-bedc1d91a0f6	g.chr12:40657633A>G	ENST00000298910.7	+	14	1644	c.1586A>G	c.(1585-1587)aAg>aGg	p.K529R	LRRK2_ENST00000343742.2_Missense_Mutation_p.K529R	NM_198578.3	NP_940980	Q5S007	LRRK2_HUMAN	leucine-rich repeat kinase 2	529					activation of MAPKK activity|determination of adult lifespan|exploration behavior|intracellular distribution of mitochondria|negative regulation of branching morphogenesis of a nerve|negative regulation of dendritic spine morphogenesis|negative regulation of neuroblast proliferation|negative regulation of neuron maturation|neuromuscular junction development|neuron death|peptidyl-serine phosphorylation|positive regulation of autophagy|positive regulation of dopamine receptor signaling pathway|positive regulation of programmed cell death|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of protein ubiquitination|protein autophosphorylation|regulation of kidney size|regulation of locomotion|regulation of membrane potential|response to oxidative stress|small GTPase mediated signal transduction|tangential migration from the subventricular zone to the olfactory bulb	external side of mitochondrial outer membrane	ATP binding|GTP binding|GTP-dependent protein kinase activity|GTPase activator activity|MAP kinase kinase activity|protein homodimerization activity|tubulin binding			NS(3)|biliary_tract(1)|breast(6)|central_nervous_system(2)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(23)|large_intestine(31)|lung(55)|ovary(15)|pancreas(2)|prostate(4)|skin(4)|stomach(9)|upper_aerodigestive_tract(7)|urinary_tract(2)	181	all_cancers(12;0.00108)|Breast(8;0.218)	Lung NSC(34;0.0942)|all_lung(34;0.11)				TTTCATCATAAGCTAAATATG	0.308000													4	53					0	0	1	0	0
P4HA1	5033	broad.mit.edu	37	10	74810921	74810921	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-AAN4-01A-11D-A42E-08	TCGA-XF-AAN4-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ef58d603-784f-406e-b97d-ab2ce298601d	a06ce9e1-7c84-4520-aa93-bedc1d91a0f6	g.chr10:74810921C>T	ENST00000412021.2	-	8	1123	c.790G>A	c.(790-792)Gat>Aat	p.D264N	P4HA1_ENST00000440381.1_Missense_Mutation_p.D264N|P4HA1_ENST00000373008.2_Missense_Mutation_p.D264N|P4HA1_ENST00000263556.3_Missense_Mutation_p.D264N|P4HA1_ENST00000394890.2_Missense_Mutation_p.D264N|P4HA1_ENST00000307116.2_Missense_Mutation_p.D264N	NM_001142595.1	NP_001136067.1	P13674	P4HA1_HUMAN	prolyl 4-hydroxylase, alpha polypeptide I	264						endoplasmic reticulum lumen|mitochondrion	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-proline 4-dioxygenase activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(8)|ovary(1)	15	Prostate(51;0.0198)				Hydralazine(DB01275)|L-Proline(DB00172)|Succinic acid(DB00139)|Vitamin C(DB00126)	GATTGGTCATCTGAAGCAGAC	0.393000													4	117					0	0	1	0	0
SLC24A2	25769	broad.mit.edu	37	9	19786781	19786781	+	Silent	SNP	A	A	G			TCGA-XF-AAN4-01A-11D-A42E-08	TCGA-XF-AAN4-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ef58d603-784f-406e-b97d-ab2ce298601d	a06ce9e1-7c84-4520-aa93-bedc1d91a0f6	g.chr9:19786781A>G	ENST00000341998.2	-	1	145	c.84T>C	c.(82-84)taT>taC	p.Y28Y	SLC24A2_ENST00000286344.3_Silent_p.Y28Y	NM_001193288.2|NM_020344.3	NP_001180217.1|NP_065077.1	Q9UI40	NCKX2_HUMAN	solute carrier family 24 (sodium/potassium/calcium exchanger), member 2	28					visual perception	integral to membrane|plasma membrane	calcium, potassium:sodium antiporter activity|symporter activity			endometrium(3)|kidney(1)|large_intestine(9)|lung(13)|ovary(3)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	33				GBM - Glioblastoma multiforme(1;1.67e-55)|Lung(42;0.0443)		TCTTGACACTATAATGTCTTC	0.443000													25	114					0	0	1	0	0
MLLT3	4300	broad.mit.edu	37	9	20414373	20414373	+	Silent	SNP	G	G	A			TCGA-XF-AAN4-01A-11D-A42E-08	TCGA-XF-AAN4-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ef58d603-784f-406e-b97d-ab2ce298601d	a06ce9e1-7c84-4520-aa93-bedc1d91a0f6	g.chr9:20414373G>A	ENST00000380338.4	-	5	757	c.471C>T	c.(469-471)agC>agT	p.S157S	MLLT3_ENST00000355930.6_5'UTR|MLLT3_ENST00000475957.1_5'UTR|MLLT3_ENST00000429426.2_Silent_p.S154S	NM_004529.2	NP_004520.2	P42568	AF9_HUMAN	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3	157	Poly-Ser.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding	p.S157S(5)		central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(6)|lung(24)|ovary(1)|prostate(4)|skin(1)|urinary_tract(7)	66				GBM - Glioblastoma multiforme(3;4.35e-105)|Lung(42;3.48e-06)|LUSC - Lung squamous cell carcinoma(42;7.92e-05)		tgctgctgctgctactgctgc	0.527000			T	MLL	ALL								4	81					0	0	1	0	0
USP34	9736	broad.mit.edu	37	2	61493245	61493245	+	Missense_Mutation	SNP	G	G	T			TCGA-XF-AAN4-01A-11D-A42E-08	TCGA-XF-AAN4-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ef58d603-784f-406e-b97d-ab2ce298601d	a06ce9e1-7c84-4520-aa93-bedc1d91a0f6	g.chr2:61493245G>T	ENST00000398571.2	-	42	5567	c.5491C>A	c.(5491-5493)Caa>Aaa	p.Q1831K		NM_014709.3	NP_055524.3	Q70CQ2	UBP34_HUMAN	ubiquitin specific peptidase 34	1831					positive regulation of canonical Wnt receptor signaling pathway|protein K48-linked deubiquitination|ubiquitin-dependent protein catabolic process|Wnt receptor signaling pathway		cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			autonomic_ganglia(1)|breast(14)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(24)|lung(52)|ovary(8)|prostate(10)|skin(6)|urinary_tract(2)	138			Epithelial(17;0.229)			TTTGGCTGTTGTCGGTCCTTT	0.388000													6	84					0.0293803	0.0299799	1	1	0
COL6A2	1292	broad.mit.edu	37	21	47544582	47544582	+	Silent	SNP	T	T	A			TCGA-XF-AAN4-01A-11D-A42E-08	TCGA-XF-AAN4-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ef58d603-784f-406e-b97d-ab2ce298601d	a06ce9e1-7c84-4520-aa93-bedc1d91a0f6	g.chr21:47544582T>A	ENST00000300527.4	+	22	1793	c.1689T>A	c.(1687-1689)ccT>ccA	p.P563P	COL6A2_ENST00000409416.1_Silent_p.P563P|COL6A2_ENST00000310645.5_Silent_p.P563P|COL6A2_ENST00000357838.4_Silent_p.P563P|COL6A2_ENST00000397763.1_Silent_p.P563P	NM_001849.3	NP_001840.3	P12110	CO6A2_HUMAN	collagen, type VI, alpha 2	563	Triple-helical region.				axon guidance|cell-cell adhesion|extracellular matrix organization|protein heterotrimerization	collagen|extracellular space|protein complex	extracellular matrix structural constituent|protein binding, bridging			NS(1)|breast(1)|central_nervous_system(7)|endometrium(7)|kidney(5)|liver(1)|lung(15)|ovary(2)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	43	Breast(49;0.245)			Colorectal(79;0.0303)|READ - Rectum adenocarcinoma(84;0.0649)		CTGGTCCCCCTGGTGAGCCAG	0.667000													4	29					0	0	1	0	0
AFF2	2334	broad.mit.edu	37	X	148037370	148037370	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-AAN4-01A-11D-A42E-08	TCGA-XF-AAN4-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ef58d603-784f-406e-b97d-ab2ce298601d	a06ce9e1-7c84-4520-aa93-bedc1d91a0f6	g.chrX:148037370C>T	ENST00000370460.2	+	11	2274	c.1795C>T	c.(1795-1797)Cgg>Tgg	p.R599W	AFF2_ENST00000370457.5_Missense_Mutation_p.R566W|AFF2_ENST00000286437.5_Missense_Mutation_p.R240W|AFF2_ENST00000342251.3_Missense_Mutation_p.R566W	NM_001169123.1|NM_002025.3	NP_001162594.1|NP_002016.2	P51816	AFF2_HUMAN	AF4/FMR2 family, member 2	599					brain development|mRNA processing|regulation of RNA splicing|RNA splicing	nuclear speck	G-quadruplex RNA binding|protein binding			breast(5)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(29)|liver(2)|lung(39)|ovary(4)|pancreas(5)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	109	Acute lymphoblastic leukemia(192;6.56e-05)					AGCCCGTCCACGGCCCACTCA	0.468000													10	170					0	0	1	0	0
ADCY10	55811	broad.mit.edu	37	1	167870945	167870945	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-AAN4-01A-11D-A42E-08	TCGA-XF-AAN4-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ef58d603-784f-406e-b97d-ab2ce298601d	a06ce9e1-7c84-4520-aa93-bedc1d91a0f6	g.chr1:167870945C>G	ENST00000367848.1	-	5	612	c.115G>C	c.(115-117)Gag>Cag	p.E39Q	ADCY10_ENST00000545172.1_Intron|ADCY10_ENST00000367851.4_Missense_Mutation_p.E131Q			Q96PN6	ADCYA_HUMAN	adenylate cyclase 10 (soluble)	131					intracellular signal transduction|spermatogenesis	cytoskeleton|cytosol|perinuclear region of cytoplasm|plasma membrane|soluble fraction	adenylate cyclase activity|ATP binding|magnesium ion binding			autonomic_ganglia(1)|breast(1)|central_nervous_system(3)|cervix(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(11)|lung(26)|ovary(2)|prostate(4)|skin(6)|stomach(1)|urinary_tract(1)	63						TCCTGGGTCTCAAACAATCCA	0.483000													4	113					0	0	1	0	0
LY75	4065	broad.mit.edu	37	2	160734841	160734841	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-AAN4-01A-11D-A42E-08	TCGA-XF-AAN4-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ef58d603-784f-406e-b97d-ab2ce298601d	a06ce9e1-7c84-4520-aa93-bedc1d91a0f6	g.chr2:160734841C>G	ENST00000263636.4	-	11	1795	c.1768G>C	c.(1768-1770)Gag>Cag	p.E590Q	LY75_ENST00000554112.1_Missense_Mutation_p.E590Q|LY75_ENST00000553424.1_Missense_Mutation_p.E590Q|LY75-CD302_ENST00000505052.1_Missense_Mutation_p.E590Q|LY75-CD302_ENST00000504764.1_Missense_Mutation_p.E590Q	NM_002349.3	NP_002340.2			lymphocyte antigen 75									p.E590Q(1)		NS(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(22)|prostate(7)|skin(6)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	59				COAD - Colon adenocarcinoma(177;0.132)		TCACCTGGCTCAAGAAAATTC	0.443000													7	71					0	0	1	0	0
ATAD5	79915	broad.mit.edu	37	17	29192767	29192767	+	Missense_Mutation	SNP	A	A	T			TCGA-XF-AAN4-01A-11D-A42E-08	TCGA-XF-AAN4-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ef58d603-784f-406e-b97d-ab2ce298601d	a06ce9e1-7c84-4520-aa93-bedc1d91a0f6	g.chr17:29192767A>T	ENST00000321990.4	+	11	3560	c.3182A>T	c.(3181-3183)cAg>cTg	p.Q1061L		NM_024857.3	NP_079133.3	Q96QE3	ATAD5_HUMAN	ATPase family, AAA domain containing 5	1061					response to DNA damage stimulus	nucleus	ATP binding|nucleoside-triphosphatase activity			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(8)|kidney(3)|large_intestine(18)|lung(13)|ovary(3)|pancreas(1)	51		all_hematologic(16;0.0202)|Acute lymphoblastic leukemia(14;0.0238)|Myeloproliferative disorder(56;0.0393)				TATCAACCTCAGACTGCCAGT	0.299000													3	70					0	0	1	0	0
TMEM150B	284417	broad.mit.edu	37	19	55831949	55831949	+	Silent	SNP	G	G	T			TCGA-XF-AAN4-01A-11D-A42E-08	TCGA-XF-AAN4-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ef58d603-784f-406e-b97d-ab2ce298601d	a06ce9e1-7c84-4520-aa93-bedc1d91a0f6	g.chr19:55831949G>T	ENST00000326652.4	-	4	287	c.105C>A	c.(103-105)ctC>ctA	p.L35L	TMEM150B_ENST00000438693.1_Silent_p.L35L	NM_001282011.1	NP_001268940.1	A6NC51	T150B_HUMAN	transmembrane protein 150B	35						integral to membrane				endometrium(1)|large_intestine(1)|lung(1)	3						AGCCTTTACTGAGGTCCACAG	0.527000													10	107					2.17888e-05	2.42097e-05	1	1	0
TTK	7272	broad.mit.edu	37	6	80749413	80749413	+	Splice_Site	SNP	A	A	G			TCGA-XF-AAN4-01A-11D-A42E-08	TCGA-XF-AAN4-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ef58d603-784f-406e-b97d-ab2ce298601d	a06ce9e1-7c84-4520-aa93-bedc1d91a0f6	g.chr6:80749413A>G	ENST00000509894.1	+	19	2957	c.2128A>G	c.(2128-2130)Ata>Gta	p.I710V	TTK_ENST00000369798.2_Splice_Site_p.I711V|TTK_ENST00000230510.3_Splice_Site_p.I710V			P33981	TTK_HUMAN	TTK protein kinase	711	Protein kinase.				mitotic cell cycle spindle assembly checkpoint|mitotic spindle organization|positive regulation of cell proliferation|positive regulation of pathway-restricted SMAD protein phosphorylation	spindle	ATP binding|identical protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			endometrium(4)|kidney(2)|large_intestine(12)|lung(22)|ovary(7)|pancreas(1)|prostate(1)|stomach(3)|urinary_tract(1)	53		all_cancers(76;0.00177)|Acute lymphoblastic leukemia(125;1.24e-05)|all_hematologic(105;0.00223)|all_epithelial(107;0.2)		BRCA - Breast invasive adenocarcinoma(397;0.0321)		TTTTTCTTAGATAAGCCCCAA	0.239000													6	108					0	0	1	0	0
RUNX1T1	862	broad.mit.edu	37	8	93026964	93026964	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-AAN4-01A-11D-A42E-08	TCGA-XF-AAN4-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ef58d603-784f-406e-b97d-ab2ce298601d	a06ce9e1-7c84-4520-aa93-bedc1d91a0f6	g.chr8:93026964G>C	ENST00000523629.1	-	4	765	c.311C>G	c.(310-312)tCt>tGt	p.S104C	RUNX1T1_ENST00000360348.2_Missense_Mutation_p.S67C|RUNX1T1_ENST00000436581.2_Missense_Mutation_p.S115C|RUNX1T1_ENST00000396218.1_Missense_Mutation_p.S77C|RUNX1T1_ENST00000265814.3_Missense_Mutation_p.S104C|RUNX1T1_ENST00000521553.1_Missense_Mutation_p.S67C|RUNX1T1_ENST00000520724.1_Missense_Mutation_p.S67C|RUNX1T1_ENST00000518844.1_Missense_Mutation_p.S77C|RUNX1T1_ENST00000422361.2_Missense_Mutation_p.S67C	NM_001198626.1|NM_001198630.1|NM_001198633.1|NM_175634.2	NP_001185555.1|NP_001185559.1|NP_001185562.1|NP_783552.1	Q06455	MTG8_HUMAN	runt-related transcription factor 1; translocated to, 1 (cyclin D-related)	104	Poly-Ser.				generation of precursor metabolites and energy	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(17)|lung(54)|pancreas(1)|skin(3)|upper_aerodigestive_tract(2)	86			BRCA - Breast invasive adenocarcinoma(11;0.0141)			GGAGGAGGAAGAAGAGGAAGG	0.547000													3	50					0	0	1	0	0
CRNKL1	51340	broad.mit.edu	37	20	20033197	20033197	+	Silent	SNP	G	G	A			TCGA-XF-AAN4-01A-11D-A42E-08	TCGA-XF-AAN4-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ef58d603-784f-406e-b97d-ab2ce298601d	a06ce9e1-7c84-4520-aa93-bedc1d91a0f6	g.chr20:20033197G>A	ENST00000377340.2	-	2	304	c.273C>T	c.(271-273)tgC>tgT	p.C91C	C20orf26_ENST00000389656.3_5'UTR|C20orf26_ENST00000377309.2_5'UTR|C20orf26_ENST00000377306.1_5'UTR|CRNKL1_ENST00000377327.4_Silent_p.C79C|C20orf26_ENST00000245957.5_5'UTR	NM_001278628.1|NM_016652.4	NP_001265557.1|NP_057736.4	Q9BZJ0	CRNL1_HUMAN	crooked neck pre-mRNA splicing factor 1	91					spliceosome assembly	catalytic step 2 spliceosome|cytoplasm|nuclear speck	RNA binding			breast(2)|cervix(2)|endometrium(7)|large_intestine(11)|lung(12)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(6)	45						CCTCCTTGCGGCAGCGCGTGG	0.672000													3	25					0	0	1	0	0
GLYATL1	92292	broad.mit.edu	37	11	58711080	58711080	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-AAN4-01A-11D-A42E-08	TCGA-XF-AAN4-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ef58d603-784f-406e-b97d-ab2ce298601d	a06ce9e1-7c84-4520-aa93-bedc1d91a0f6	g.chr11:58711080G>A	ENST00000300079.5	+	2	139	c.89G>A	c.(88-90)gGa>gAa	p.G30E	RP11-142C4.6_ENST00000533954.1_RNA|GLYATL1_ENST00000317391.4_5'UTR	NM_001220496.1|NM_080661.3	NP_001207425.1|NP_542392.2	Q969I3	GLYL1_HUMAN	glycine-N-acyltransferase-like 1	0						mitochondrion	glycine N-acyltransferase activity			NS(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(19)|ovary(1)|skin(4)|urinary_tract(1)	34					Glycine(DB00145)	agtgaacacggaaggtacctg	0.453000													4	57					0	0	1	0	0
TIA1	7072	broad.mit.edu	37	2	70463276	70463276	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-AAN4-01A-11D-A42E-08	TCGA-XF-AAN4-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ef58d603-784f-406e-b97d-ab2ce298601d	a06ce9e1-7c84-4520-aa93-bedc1d91a0f6	g.chr2:70463276C>T	ENST00000433529.2	-	2	268	c.58G>A	c.(58-60)Gaa>Aaa	p.E20K	TIA1_ENST00000415783.2_Missense_Mutation_p.E20K|TIA1_ENST00000445587.1_Missense_Mutation_p.E20K|TIA1_ENST00000416149.2_Missense_Mutation_p.E20K|C2orf42_ENST00000470096.1_Intron|TIA1_ENST00000282574.4_Missense_Mutation_p.E20K	NM_022173.2	NP_071505.2	P31483	TIA1_HUMAN	TIA1 cytotoxic granule-associated RNA binding protein	20	RRM 1.				apoptosis|induction of apoptosis|regulation of nuclear mRNA splicing, via spliceosome	nucleus	nucleotide binding|poly(A) RNA binding|protein binding			endometrium(3)|kidney(2)|large_intestine(2)|lung(8)|skin(1)|urinary_tract(1)	17						ATTAGAGCTTCTGTCACATCT	0.348000													3	57					0	0	1	0	0
CNTNAP3B	728577	broad.mit.edu	37	9	43828112	43828112	+	Silent	SNP	A	A	G	rs150656228	by1000genomes	TCGA-XF-AAN4-01A-11D-A42E-08	TCGA-XF-AAN4-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ef58d603-784f-406e-b97d-ab2ce298601d	a06ce9e1-7c84-4520-aa93-bedc1d91a0f6	g.chr9:43828112A>G	ENST00000377564.3	+	9	1761	c.1368A>G	c.(1366-1368)gtA>gtG	p.V456V		NM_001201380.1	NP_001188309.1	Q96NU0	CNT3B_HUMAN	contactin associated protein-like 3B	456	Laminin G-like 2.				cell adhesion|signal transduction	integral to membrane	receptor binding			central_nervous_system(1)|endometrium(2)|lung(3)|pancreas(1)|prostate(3)	10						GGCACTCTGTATCCTTCTCTG	0.458000													3	81					0	0	1	0	0
ARMCX5	64860	broad.mit.edu	37	X	101857579	101857579	+	Missense_Mutation	SNP	A	A	G			TCGA-XF-AAN4-01A-11D-A42E-08	TCGA-XF-AAN4-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ef58d603-784f-406e-b97d-ab2ce298601d	a06ce9e1-7c84-4520-aa93-bedc1d91a0f6	g.chrX:101857579A>G	ENST00000604957.1	+	1	3132	c.510A>G	c.(508-510)atA>atG	p.I170M	RP4-769N13.6_ENST00000476910.2_RNA|ARMCX5_ENST00000541409.1_Missense_Mutation_p.I170M|ARMCX5_ENST00000246174.2_Missense_Mutation_p.I170M|RP4-769N13.7_ENST00000602441.1_RNA|ARMCX5_ENST00000537008.1_Missense_Mutation_p.I170M|ARMCX5_ENST00000372742.1_Missense_Mutation_p.I170M|ARMCX5_ENST00000536530.1_Missense_Mutation_p.I170M	NM_001168478.1	NP_001161950.1	Q6P1M9	ARMX5_HUMAN	armadillo repeat containing, X-linked 5	170							binding			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(3)|lung(7)|ovary(1)|upper_aerodigestive_tract(2)	22						AAGAAAATATATGCTCCTGGT	0.478000													5	140					0	0	1	0	0
REV3L	5980	broad.mit.edu	37	6	111688460	111688460	+	Missense_Mutation	SNP	T	T	A			TCGA-XF-AAN4-01A-11D-A42E-08	TCGA-XF-AAN4-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ef58d603-784f-406e-b97d-ab2ce298601d	a06ce9e1-7c84-4520-aa93-bedc1d91a0f6	g.chr6:111688460T>A	ENST00000435970.1	-	16	7113	c.6297A>T	c.(6295-6297)caA>caT	p.Q2099H	REV3L_ENST00000358835.3_Missense_Mutation_p.Q2177H|REV3L_ENST00000368802.3_Missense_Mutation_p.Q2177H|REV3L_ENST00000368805.1_Missense_Mutation_p.Q2177H			O60673	DPOLZ_HUMAN	REV3-like, polymerase (DNA directed), zeta, catalytic subunit	2177					DNA-dependent DNA replication|translesion synthesis	nucleus|zeta DNA polymerase complex	DNA binding|DNA-directed DNA polymerase activity|metal ion binding|nucleotide binding			NS(2)|breast(1)|endometrium(6)|kidney(7)|large_intestine(30)|lung(25)|ovary(3)|prostate(5)|skin(8)|upper_aerodigestive_tract(1)	88		all_cancers(87;7.57e-06)|Acute lymphoblastic leukemia(125;2.46e-08)|all_hematologic(75;1.08e-06)|all_epithelial(87;0.00138)|Colorectal(196;0.021)		OV - Ovarian serous cystadenocarcinoma(136;0.0314)|Epithelial(106;0.057)|all cancers(137;0.0663)		CTAGAGGCTCTTGAGGCTCAC	0.418000								DNA polymerases (catalytic subunits)					4	127					0	0	1	0	0
DDR2	4921	broad.mit.edu	37	1	162725046	162725046	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-AAN4-01A-11D-A42E-08	TCGA-XF-AAN4-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ef58d603-784f-406e-b97d-ab2ce298601d	a06ce9e1-7c84-4520-aa93-bedc1d91a0f6	g.chr1:162725046C>G	ENST00000367922.3	+	7	956	c.518C>G	c.(517-519)tCc>tGc	p.S173C	DDR2_ENST00000367921.3_Missense_Mutation_p.S173C	NM_001014796.1	NP_001014796.1	Q16832	DDR2_HUMAN	discoidin domain receptor tyrosine kinase 2		F5/8 type C.				cell adhesion	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity			central_nervous_system(2)|kidney(1)|lung(2)|ovary(1)|skin(1)	7	all_hematologic(112;0.115)		BRCA - Breast invasive adenocarcinoma(70;0.113)			ACCGACCACTCCATGAATGTG	0.473000													16	70					0	0	1	0	0
CYP27B1	1594	broad.mit.edu	37	12	58158851	58158851	+	Missense_Mutation	SNP	G	G	T			TCGA-XF-AAN4-01A-11D-A42E-08	TCGA-XF-AAN4-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ef58d603-784f-406e-b97d-ab2ce298601d	a06ce9e1-7c84-4520-aa93-bedc1d91a0f6	g.chr12:58158851G>T	ENST00000228606.4	-	4	942	c.733C>A	c.(733-735)Ctt>Att	p.L245I		NM_000785.3	NP_000776.1	O15528	CP27B_HUMAN	cytochrome P450, family 27, subfamily B, polypeptide 1	245					bone mineralization|calcium ion homeostasis|calcium ion transport|decidualization|G1 to G0 transition|hormone biosynthetic process|negative regulation of calcidiol 1-monooxygenase activity|negative regulation of cell growth|negative regulation of cell proliferation|positive regulation of keratinocyte differentiation|positive regulation of vitamin D 24-hydroxylase activity|positive regulation of vitamin D receptor signaling pathway|regulation of bone mineralization|response to estrogen stimulus|response to interferon-gamma|response to lipopolysaccharide|response to tumor necrosis factor|response to vitamin D|vitamin D biosynthetic process|xenobiotic metabolic process	mitochondrial outer membrane	calcidiol 1-monooxygenase activity|electron carrier activity|heme binding			central_nervous_system(3)|endometrium(1)|kidney(1)|large_intestine(3)|lung(5)|prostate(1)|urinary_tract(1)	15	all_cancers(7;8.09e-80)|Lung NSC(6;2.26e-27)|all_lung(6;1.99e-25)|all_epithelial(6;3.62e-18)|Glioma(12;6.95e-05)|all_neural(12;0.00016)|Melanoma(17;0.122)		GBM - Glioblastoma multiforme(5;1.97e-113)|all cancers(5;1.54e-78)|BRCA - Breast invasive adenocarcinoma(9;0.0294)		Calcidiol(DB00146)|Calcitriol(DB00136)|Ergocalciferol(DB00153)	CCAGGCACAAGGTGGCGCAGC	0.617000											OREG0021953	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	3	42					0.014758	0.0153729	1	1	0
BRD9	65980	broad.mit.edu	37	5	865548	865548	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-AAN4-01A-11D-A42E-08	TCGA-XF-AAN4-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ef58d603-784f-406e-b97d-ab2ce298601d	a06ce9e1-7c84-4520-aa93-bedc1d91a0f6	g.chr5:865548C>G	ENST00000323510.4	-	12	1385	c.1386G>C	c.(1384-1386)gaG>gaC	p.E462D	BRD9_ENST00000483173.1_Missense_Mutation_p.E505D|BRD9_ENST00000467963.1_Missense_Mutation_p.E558D|BRD9_ENST00000388890.4_Missense_Mutation_p.E442D			Q9H8M2	BRD9_HUMAN	bromodomain containing 9	558							nucleic acid binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(7)|lung(11)|ovary(2)|pancreas(1)|prostate(3)	29			Epithelial(17;0.00202)|OV - Ovarian serous cystadenocarcinoma(19;0.00353)|all cancers(22;0.00815)|Lung(60;0.185)			GCTGGTCCCTCTCGGAGGCGT	0.657000													4	58					0	0	1	0	0
LILRA1	11024	broad.mit.edu	37	19	55107895	55107895	+	Silent	SNP	A	A	G			TCGA-XF-AAN4-01A-11D-A42E-08	TCGA-XF-AAN4-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ef58d603-784f-406e-b97d-ab2ce298601d	a06ce9e1-7c84-4520-aa93-bedc1d91a0f6	g.chr19:55107895A>G	ENST00000251372.3	+	7	1382	c.1200A>G	c.(1198-1200)tcA>tcG	p.S400S	LILRB1_ENST00000396321.2_Intron|LILRB1_ENST00000448689.1_Intron|LILRA1_ENST00000453777.1_Intron|LILRB1_ENST00000418536.2_Intron|LILRA1_ENST00000473156.1_3'UTR	NM_006863.2	NP_006854.1	O75019	LIRA1_HUMAN	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1	400	Ig-like C2-type 4.				cell surface receptor linked signaling pathway|defense response|regulation of immune response	integral to membrane|plasma membrane	antigen binding|transmembrane receptor activity			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(5)|liver(1)|lung(23)|ovary(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)	47				GBM - Glioblastoma multiforme(193;0.0348)		GCTACGGCTCACTCAGCTCCA	0.567000													6	76					0	0	1	0	0
GPR112	139378	broad.mit.edu	37	X	135430300	135430300	+	Missense_Mutation	SNP	A	A	G			TCGA-XF-AAN4-01A-11D-A42E-08	TCGA-XF-AAN4-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ef58d603-784f-406e-b97d-ab2ce298601d	a06ce9e1-7c84-4520-aa93-bedc1d91a0f6	g.chrX:135430300A>G	ENST00000394143.1	+	6	4726	c.4435A>G	c.(4435-4437)Aca>Gca	p.T1479A	GPR112_ENST00000412101.1_Missense_Mutation_p.T1274A|GPR112_ENST00000370652.1_Missense_Mutation_p.T1479A|GPR112_ENST00000287534.4_Missense_Mutation_p.T1416A|GPR112_ENST00000394141.1_Missense_Mutation_p.T1274A	NM_153834.3	NP_722576.3	Q8IZF6	GP112_HUMAN	G protein-coupled receptor 112	1479					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(2)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(33)|lung(97)|ovary(5)|pancreas(2)|prostate(4)|skin(10)|upper_aerodigestive_tract(1)|urinary_tract(2)	199	Acute lymphoblastic leukemia(192;0.000127)					TGACGGTTTTACAGTTCTCTC	0.443000													4	121					0	0	1	0	0
SPAST	6683	broad.mit.edu	37	2	32312563	32312563	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-AAN4-01A-11D-A42E-08	TCGA-XF-AAN4-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ef58d603-784f-406e-b97d-ab2ce298601d	a06ce9e1-7c84-4520-aa93-bedc1d91a0f6	g.chr2:32312563G>A	ENST00000315285.3	+	2	543	c.418G>A	c.(418-420)Gga>Aga	p.G140R	SPAST_ENST00000345662.1_Missense_Mutation_p.G140R	NM_014946.3	NP_055761.2	Q9UBP0	SPAST_HUMAN	spastin	140	MIT.|Required for interaction with RTN1.|Required for interaction with microtubules.|Required for midbody localization.|Sufficient for interaction with CHMP1B.				cell cycle|cell death|cell differentiation|cytokinesis, completion of separation|ER to Golgi vesicle-mediated transport|microtubule bundle formation|microtubule severing|nervous system development|protein hexamerization|protein homooligomerization	endoplasmic reticulum|endosome|integral to membrane|microtubule|microtubule organizing center|nucleus|perinuclear region of cytoplasm|spindle	alpha-tubulin binding|ATP binding|beta-tubulin binding|microtubule binding|microtubule-severing ATPase activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(6)|lung(8)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	25	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.208)					TTTTAAAGCAGGACAGAAGGA	0.328000													4	64					0	0	1	0	0
UBASH3B	84959	broad.mit.edu	37	11	122659876	122659876	+	Silent	SNP	C	C	T			TCGA-XF-AAN4-01A-11D-A42E-08	TCGA-XF-AAN4-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ef58d603-784f-406e-b97d-ab2ce298601d	a06ce9e1-7c84-4520-aa93-bedc1d91a0f6	g.chr11:122659876C>T	ENST00000284273.5	+	6	1215	c.840C>T	c.(838-840)ttC>ttT	p.F280F		NM_032873.4	NP_116262.2	Q8TF42	UBS3B_HUMAN	ubiquitin associated and SH3 domain containing B	280	SH3.					cytoplasm|nucleus	protein tyrosine phosphatase activity			breast(1)|central_nervous_system(1)|endometrium(3)|large_intestine(5)|lung(11)|prostate(1)|skin(2)|stomach(2)	26		Breast(109;0.00254)|Medulloblastoma(222;0.00877)|Lung NSC(97;0.0183)|all_lung(97;0.0186)|all_neural(223;0.0381)|all_hematologic(192;0.104)		BRCA - Breast invasive adenocarcinoma(274;1.37e-05)|OV - Ovarian serous cystadenocarcinoma(99;0.0463)		CCGGGGACTTCATCTTCATGT	0.542000													8	153					0	0	1	0	0
USP34	9736	broad.mit.edu	37	2	61493247	61493247	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-AAN4-01A-11D-A42E-08	TCGA-XF-AAN4-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ef58d603-784f-406e-b97d-ab2ce298601d	a06ce9e1-7c84-4520-aa93-bedc1d91a0f6	g.chr2:61493247C>T	ENST00000398571.2	-	42	5565	c.5489G>A	c.(5488-5490)cGa>cAa	p.R1830Q		NM_014709.3	NP_055524.3	Q70CQ2	UBP34_HUMAN	ubiquitin specific peptidase 34	1830					positive regulation of canonical Wnt receptor signaling pathway|protein K48-linked deubiquitination|ubiquitin-dependent protein catabolic process|Wnt receptor signaling pathway		cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			autonomic_ganglia(1)|breast(14)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(24)|lung(52)|ovary(8)|prostate(10)|skin(6)|urinary_tract(2)	138			Epithelial(17;0.229)			TGGCTGTTGTCGGTCCTTTAG	0.388000													6	85					0	0	1	0	0
MFSD6	54842	broad.mit.edu	37	2	191302088	191302088	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-AAN4-01A-11D-A42E-08	TCGA-XF-AAN4-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ef58d603-784f-406e-b97d-ab2ce298601d	a06ce9e1-7c84-4520-aa93-bedc1d91a0f6	g.chr2:191302088G>A	ENST00000392328.1	+	3	1657	c.1333G>A	c.(1333-1335)Gtg>Atg	p.V445M	MFSD6_ENST00000281416.7_Missense_Mutation_p.V445M	NM_017694.3	NP_060164.3	Q6ZSS7	MFSD6_HUMAN	major facilitator superfamily domain containing 6	445					transmembrane transport	integral to membrane				breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|large_intestine(2)|lung(5)|ovary(2)|prostate(1)|skin(3)|stomach(1)	23						GCTCTGCAGCGTGCAGTATGG	0.498000													6	165					0	0	1	0	0
SYNE2	23224	broad.mit.edu	37	14	64473846	64473846	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-AAN4-01A-11D-A42E-08	TCGA-XF-AAN4-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ef58d603-784f-406e-b97d-ab2ce298601d	a06ce9e1-7c84-4520-aa93-bedc1d91a0f6	g.chr14:64473846C>G	ENST00000358025.3	+	31	4713	c.4483C>G	c.(4483-4485)Cca>Gca	p.P1495A	SYNE2_ENST00000344113.4_Missense_Mutation_p.P1495A|SYNE2_ENST00000357395.3_5'UTR|SYNE2_ENST00000554584.1_Missense_Mutation_p.P1495A	NM_182914.2	NP_878918.2	Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	1495					centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			NS(5)|breast(17)|central_nervous_system(3)|cervix(8)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(21)|large_intestine(34)|lung(75)|ovary(10)|pancreas(2)|prostate(8)|skin(8)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(4)	224				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		TAATTCTCTTCCACACTTCAA	0.373000													8	147					0	0	1	0	0
PAPLN	89932	broad.mit.edu	37	14	73718244	73718244	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-AAN4-01A-11D-A42E-08	TCGA-XF-AAN4-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ef58d603-784f-406e-b97d-ab2ce298601d	a06ce9e1-7c84-4520-aa93-bedc1d91a0f6	g.chr14:73718244G>C	ENST00000427855.1	+	8	742	c.640G>C	c.(640-642)Gac>Cac	p.D214H	PAPLN_ENST00000555445.1_Missense_Mutation_p.D214H|PAPLN_ENST00000554301.1_Missense_Mutation_p.D214H|PAPLN_ENST00000381166.3_Missense_Mutation_p.D214H|PAPLN_ENST00000340738.5_Intron			O95428	PPN_HUMAN	papilin, proteoglycan-like sulfated glycoprotein	214						proteinaceous extracellular matrix	metalloendopeptidase activity|serine-type endopeptidase inhibitor activity|zinc ion binding			NS(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(4)|lung(11)|ovary(3)|pancreas(3)|prostate(5)|skin(3)|upper_aerodigestive_tract(3)	42				BRCA - Breast invasive adenocarcinoma(234;0.00394)|OV - Ovarian serous cystadenocarcinoma(108;0.0468)		CATCCTCATCGACGAGGCTGC	0.642000													3	27					0	0	1	0	0
ZNF423	23090	broad.mit.edu	37	16	49660147	49660147	+	Missense_Mutation	SNP	T	T	C			TCGA-XF-AAN4-01A-11D-A42E-08	TCGA-XF-AAN4-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ef58d603-784f-406e-b97d-ab2ce298601d	a06ce9e1-7c84-4520-aa93-bedc1d91a0f6	g.chr16:49660147T>C	ENST00000561648.1	-	5	3564	c.3511A>G	c.(3511-3513)Atc>Gtc	p.I1171V	ZNF423_ENST00000535559.1_Missense_Mutation_p.I1054V|ZNF423_ENST00000562520.1_Missense_Mutation_p.I1111V|ZNF423_ENST00000262383.2_Missense_Mutation_p.I1171V|ZNF423_ENST00000563137.2_Missense_Mutation_p.I1111V|ZNF423_ENST00000567169.1_Missense_Mutation_p.I1054V|ZNF423_ENST00000562871.1_Missense_Mutation_p.I1111V	NM_001271620.1	NP_001258549.1	Q2M1K9	ZN423_HUMAN	zinc finger protein 423	1171					cell differentiation|negative regulation of transcription, DNA-dependent|nervous system development|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(8)|kidney(6)|large_intestine(16)|lung(47)|ovary(1)|pancreas(2)|prostate(4)|skin(1)|urinary_tract(2)	89		all_cancers(37;0.0155)				TGGCACTTGATGCACTGGTAT	0.468000													5	118					0	0	1	0	0
SCG2	7857	broad.mit.edu	37	2	224462229	224462229	+	Missense_Mutation	SNP	A	A	G			TCGA-XF-AAN4-01A-11D-A42E-08	TCGA-XF-AAN4-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ef58d603-784f-406e-b97d-ab2ce298601d	a06ce9e1-7c84-4520-aa93-bedc1d91a0f6	g.chr2:224462229A>G	ENST00000305409.2	-	2	2004	c.1772T>C	c.(1771-1773)aTg>aCg	p.M591T		NM_003469.4	NP_003460.2	P13521	SCG2_HUMAN	secretogranin II	591					angiogenesis|endothelial cell migration|eosinophil chemotaxis|induction of positive chemotaxis|inflammatory response|MAPKKK cascade|negative regulation of apoptosis|negative regulation of endothelial cell proliferation|positive regulation of endothelial cell proliferation|protein secretion	extracellular space|stored secretory granule	chemoattractant activity|cytokine activity			NS(1)|breast(1)|endometrium(1)|kidney(6)|large_intestine(10)|liver(1)|lung(16)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(4)	44		Renal(207;0.0112)|Lung NSC(271;0.0185)|all_lung(227;0.0271)		Epithelial(121;8.16e-11)|all cancers(144;4.66e-08)|Lung(261;0.00714)|LUSC - Lung squamous cell carcinoma(224;0.008)		CAGCACTTTCATTAACAGATC	0.458000													8	117					0	0	1	0	0
VEZT	55591	broad.mit.edu	37	12	95645809	95645809	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-AAN4-01A-11D-A42E-08	TCGA-XF-AAN4-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ef58d603-784f-406e-b97d-ab2ce298601d	a06ce9e1-7c84-4520-aa93-bedc1d91a0f6	g.chr12:95645809G>C	ENST00000436874.1	+	2	235	c.130G>C	c.(130-132)Gag>Cag	p.E44Q	VEZT_ENST00000356859.4_3'UTR|VEZT_ENST00000261219.6_5'UTR	NM_017599.3	NP_060069.3	Q9HBM0	VEZA_HUMAN	vezatin, adherens junctions transmembrane protein	44						acrosomal vesicle|adherens junction|integral to membrane|nucleus				endometrium(2)|kidney(3)|large_intestine(1)|lung(14)|ovary(2)|upper_aerodigestive_tract(1)	23						ATGCACAACAGAGGGACAACA	0.393000													3	76					0	0	1	0	0
SORCS3	22986	broad.mit.edu	37	10	106737201	106737201	+	Missense_Mutation	SNP	T	T	C			TCGA-XF-AAN4-01A-11D-A42E-08	TCGA-XF-AAN4-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ef58d603-784f-406e-b97d-ab2ce298601d	a06ce9e1-7c84-4520-aa93-bedc1d91a0f6	g.chr10:106737201T>C	ENST00000369701.3	+	4	1131	c.904T>C	c.(904-906)Ttt>Ctt	p.F302L		NM_014978.1	NP_055793.1	Q9UPU3	SORC3_HUMAN	sortilin-related VPS10 domain containing receptor 3	302						integral to membrane	neuropeptide receptor activity			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(19)|lung(63)|ovary(6)|pancreas(1)|prostate(6)|skin(8)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	131		Colorectal(252;0.134)|Breast(234;0.142)|Lung NSC(174;0.191)		Epithelial(162;1.58e-07)|all cancers(201;1.02e-05)|BRCA - Breast invasive adenocarcinoma(275;0.0628)		GAGCCTGCTCTTTCATCCCAA	0.463000													3	50					0	0	1	0	0
GNS	2799	broad.mit.edu	37	12	65137014	65137014	+	Silent	SNP	C	C	T			TCGA-XF-AAN4-01A-11D-A42E-08	TCGA-XF-AAN4-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ef58d603-784f-406e-b97d-ab2ce298601d	a06ce9e1-7c84-4520-aa93-bedc1d91a0f6	g.chr12:65137014C>T	ENST00000258145.3	-	6	869	c.699G>A	c.(697-699)gcG>gcA	p.A233A	GNS_ENST00000542058.1_Silent_p.A213A|GNS_ENST00000543646.1_Silent_p.A265A|GNS_ENST00000418919.2_Silent_p.A177A	NM_002076.3	NP_002067.1	P15586	GNS_HUMAN	glucosamine (N-acetyl)-6-sulfatase	233						lysosome	metal ion binding|N-acetylglucosamine-6-sulfatase activity|protein binding			central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(5)|liver(1)|lung(4)	15	Lung NSC(1;7.25e-14)|all_lung(1;1.25e-12)		LUAD - Lung adenocarcinoma(6;0.115)	GBM - Glioblastoma multiforme(28;0.0435)		GCGAATGAGGCGCTGGAGTGG	0.463000													4	72					0	0	1	0	0
CUBN	8029	broad.mit.edu	37	10	17145218	17145218	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-AAN4-01A-11D-A42E-08	TCGA-XF-AAN4-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ef58d603-784f-406e-b97d-ab2ce298601d	a06ce9e1-7c84-4520-aa93-bedc1d91a0f6	g.chr10:17145218G>A	ENST00000377833.4	-	13	1501	c.1436C>T	c.(1435-1437)tCa>tTa	p.S479L		NM_001081.3	NP_001072.2	O60494	CUBN_HUMAN	cubilin (intrinsic factor-cobalamin receptor)	479	CUB 1.				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			breast(8)|central_nervous_system(4)|cervix(1)|endometrium(18)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(42)|liver(1)|lung(107)|ovary(9)|pancreas(2)|prostate(3)|skin(9)|stomach(3)|upper_aerodigestive_tract(11)|urinary_tract(8)	241					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	ATTTATTCCTGAGAGGGACTC	0.428000													3	52					0	0	1	0	0
PAPPA	5069	broad.mit.edu	37	9	118950375	118950375	+	Missense_Mutation	SNP	A	A	G			TCGA-XF-AAN4-01A-11D-A42E-08	TCGA-XF-AAN4-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ef58d603-784f-406e-b97d-ab2ce298601d	a06ce9e1-7c84-4520-aa93-bedc1d91a0f6	g.chr9:118950375A>G	ENST00000328252.3	+	2	1727	c.1358A>G	c.(1357-1359)cAc>cGc	p.H453R		NM_002581.3	NP_002572.2	Q13219	PAPP1_HUMAN	pregnancy-associated plasma protein A, pappalysin 1	453	Metalloprotease.				cell differentiation|female pregnancy	cytoplasm|extracellular region|membrane	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(4)|endometrium(9)|kidney(2)|large_intestine(23)|lung(33)|ovary(4)|pancreas(2)|prostate(5)|skin(7)|stomach(1)|upper_aerodigestive_tract(6)|urinary_tract(1)	98						AAGAAGCAGCACAACGGGGTG	0.572000													4	35					0	0	1	0	0
MTA2	9219	broad.mit.edu	37	11	62362492	62362492	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-AAN4-01A-11D-A42E-08	TCGA-XF-AAN4-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ef58d603-784f-406e-b97d-ab2ce298601d	a06ce9e1-7c84-4520-aa93-bedc1d91a0f6	g.chr11:62362492G>C	ENST00000278823.2	-	15	1923	c.1534C>G	c.(1534-1536)Ctg>Gtg	p.L512V	MTA2_ENST00000527204.1_Missense_Mutation_p.L339V|MTA2_ENST00000524902.1_Missense_Mutation_p.L339V	NM_004739.3	NP_004730.2	O94776	MTA2_HUMAN	metastasis associated 1 family, member 2	512					chromatin assembly or disassembly	NuRD complex	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(2)|kidney(2)|large_intestine(5)|lung(7)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(4)	26						AGCCGCACCAGAGGGTGAATC	0.542000													5	116					0	0	1	0	0
MYO1C	4641	broad.mit.edu	37	17	1375431	1375431	+	Missense_Mutation	SNP	T	T	A			TCGA-XF-AAN4-01A-11D-A42E-08	TCGA-XF-AAN4-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ef58d603-784f-406e-b97d-ab2ce298601d	a06ce9e1-7c84-4520-aa93-bedc1d91a0f6	g.chr17:1375431T>A	ENST00000359786.5	-	18	2213	c.1889A>T	c.(1888-1890)gAt>gTt	p.D630V	MYO1C_ENST00000545534.2_Missense_Mutation_p.D606V|MYO1C_ENST00000438665.2_Missense_Mutation_p.D611V|MYO1C_ENST00000575158.1_Missense_Mutation_p.D595V|MYO1C_ENST00000361007.2_Missense_Mutation_p.D595V	NM_001080779.1	NP_001074248.1	O00159	MYO1C_HUMAN	myosin IC	630	Myosin head-like.				mRNA transport|protein transport|transmembrane transport	basal plasma membrane|cytoplasm|filamentous actin|lateral plasma membrane|nuclear pore|nucleolus|nucleoplasm|stereocilium membrane	actin binding|ATP binding|calmodulin binding|motor activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(1)|liver(2)|lung(7)|upper_aerodigestive_tract(1)|urinary_tract(2)	17				UCEC - Uterine corpus endometrioid carcinoma (25;0.0822)		CTGTTTGGCATCATTGGGTTT	0.677000													4	59					0	0	1	0	0
GPR50	9248	broad.mit.edu	37	X	150349688	150349688	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-AAN4-01A-11D-A42E-08	TCGA-XF-AAN4-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ef58d603-784f-406e-b97d-ab2ce298601d	a06ce9e1-7c84-4520-aa93-bedc1d91a0f6	g.chrX:150349688C>T	ENST00000218316.3	+	2	1702	c.1633C>T	c.(1633-1635)Ccc>Tcc	p.P545S		NM_004224.3	NP_004215.2	Q13585	MTR1L_HUMAN	G protein-coupled receptor 50	545	Pro-rich.				cell-cell signaling	integral to plasma membrane	melatonin receptor activity			breast(4)|central_nervous_system(1)|endometrium(8)|kidney(1)|large_intestine(6)|lung(14)|ovary(1)|pancreas(1)|prostate(1)|stomach(1)	38	Acute lymphoblastic leukemia(192;6.56e-05)					CTCCCATTGCCCCGAGATCCC	0.642000													3	64					0	0	1	0	0
KIF1B	23095	broad.mit.edu	37	1	10364405	10364405	+	Silent	SNP	C	C	A			TCGA-XF-AAN4-01A-11D-A42E-08	TCGA-XF-AAN4-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ef58d603-784f-406e-b97d-ab2ce298601d	a06ce9e1-7c84-4520-aa93-bedc1d91a0f6	g.chr1:10364405C>A	ENST00000377093.4	+	21	3315	c.3162C>A	c.(3160-3162)ctC>ctA	p.L1054L	KIF1B_ENST00000263934.6_Intron|KIF1B_ENST00000377086.1_Intron|KIF1B_ENST00000377081.1_Intron|KIF1B_ENST00000377083.1_Silent_p.L1054L	NM_183416.3	NP_904325.2	O60333	KIF1B_HUMAN	kinesin family member 1B	0					anterograde axon cargo transport|apoptosis|neuromuscular synaptic transmission|neuron-neuron synaptic transmission	cytoplasmic vesicle membrane|microtubule|microtubule associated complex|mitochondrion	ATP binding|ATPase activity|kinesin binding|microtubule motor activity|protein binding			breast(2)|endometrium(7)|kidney(8)|large_intestine(9)|lung(29)|ovary(3)|prostate(3)|skin(5)|stomach(3)|upper_aerodigestive_tract(2)	71	Ovarian(185;0.203)	all_lung(284;1.31e-05)|Lung NSC(185;2.2e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0259)|Colorectal(212;9.79e-07)|COAD - Colon adenocarcinoma(227;0.000143)|BRCA - Breast invasive adenocarcinoma(304;0.000413)|Kidney(185;0.00134)|KIRC - Kidney renal clear cell carcinoma(229;0.0037)|STAD - Stomach adenocarcinoma(132;0.0113)|READ - Rectum adenocarcinoma(331;0.0642)		GCAATTCTCTCAATAATGGCC	0.493000													4	122					0.184627	0.184627	1	1	0
RP1	6101	broad.mit.edu	37	8	55533897	55533897	+	Missense_Mutation	SNP	C	C	A			TCGA-XF-AAN4-01A-11D-A42E-08	TCGA-XF-AAN4-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ef58d603-784f-406e-b97d-ab2ce298601d	a06ce9e1-7c84-4520-aa93-bedc1d91a0f6	g.chr8:55533897C>A	ENST00000220676.1	+	2	519	c.371C>A	c.(370-372)cCg>cAg	p.P124Q		NM_006269.1	NP_006260.1	P56715	RP1_HUMAN	retinitis pigmentosa 1 (autosomal dominant)	124					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			NS(4)|breast(6)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(29)|lung(69)|ovary(6)|pancreas(1)|prostate(9)|skin(17)|upper_aerodigestive_tract(3)|urinary_tract(2)	169		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			CGTCGGCGCCCGCGGCCCTGG	0.706000													5	54					0.014758	0.0153729	1	1	0
NCKAP5	344148	broad.mit.edu	37	2	133541237	133541237	+	Silent	SNP	A	A	T			TCGA-XF-AAN4-01A-11D-A42E-08	TCGA-XF-AAN4-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ef58d603-784f-406e-b97d-ab2ce298601d	a06ce9e1-7c84-4520-aa93-bedc1d91a0f6	g.chr2:133541237A>T	ENST00000409261.1	-	14	3520	c.3147T>A	c.(3145-3147)tcT>tcA	p.S1049S	NCKAP5_ENST00000317721.6_Silent_p.S1049S|NCKAP5_ENST00000409213.1_Intron|NCKAP5_ENST00000405974.3_Intron	NM_207363.2	NP_997246.2	O14513	NCKP5_HUMAN	NCK-associated protein 5	1049							protein binding			NS(4)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(29)|lung(51)|prostate(5)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	118						TTTGGCGAGGAGAGGTTTTGG	0.552000													3	50					0	0	1	0	0
ATRX	546	broad.mit.edu	37	X	76814247	76814247	+	Missense_Mutation	SNP	T	T	G			TCGA-XF-AAN4-01A-11D-A42E-08	TCGA-XF-AAN4-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ef58d603-784f-406e-b97d-ab2ce298601d	a06ce9e1-7c84-4520-aa93-bedc1d91a0f6	g.chrX:76814247T>G	ENST00000373344.5	-	29	6611	c.6397A>C	c.(6397-6399)Att>Ctt	p.I2133L	ATRX_ENST00000395603.3_Missense_Mutation_p.I2095L|ATRX_ENST00000480283.1_5'UTR	NM_000489.3	NP_000480.3	P46100	ATRX_HUMAN	alpha thalassemia/mental retardation syndrome X-linked	2133	Helicase C-terminal.				DNA methylation|DNA recombination|DNA repair|regulation of transcription, DNA-dependent	nuclear heterochromatin	ATP binding|chromo shadow domain binding|DNA binding|DNA helicase activity|zinc ion binding	p.?(1)		bone(1)|breast(6)|central_nervous_system(31)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(15)|kidney(14)|large_intestine(1)|liver(1)|lung(40)|ovary(2)|pancreas(13)|prostate(5)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	145					Phosphatidylserine(DB00144)	TCGAATATAATTACTCGATTA	0.333000			"""Mis, F, N"""		"""Pancreatic neuroendocrine tumors, paediatric GBM"""		ATR-X (alpha thalassemia/mental retardation) syndrome						5	169					0	0	1	0	0
NPIPB15	440348	broad.mit.edu	37	16	74423917	74423917	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-AAN4-01A-11D-A42E-08	TCGA-XF-AAN4-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ef58d603-784f-406e-b97d-ab2ce298601d	a06ce9e1-7c84-4520-aa93-bedc1d91a0f6	g.chr16:74423917C>G	ENST00000429990.1	+	6	727	c.631C>G	c.(631-633)Ctt>Gtt	p.L211V						nuclear pore complex interacting protein family, member B15																		AAGAAAGCCTCTTTGCAACTG	0.453000													9	271					0	0	1	0	0
KIF20B	9585	broad.mit.edu	37	10	91532466	91532466	+	Missense_Mutation	SNP	A	A	G			TCGA-XF-AAN4-01A-11D-A42E-08	TCGA-XF-AAN4-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ef58d603-784f-406e-b97d-ab2ce298601d	a06ce9e1-7c84-4520-aa93-bedc1d91a0f6	g.chr10:91532466A>G	ENST00000416354.1	+	32	5425	c.5353A>G	c.(5353-5355)Atg>Gtg	p.M1785V	KIF20B_ENST00000260753.4_Missense_Mutation_p.M1715V|KIF20B_ENST00000371728.3_Missense_Mutation_p.M1755V|KIF20B_ENST00000478929.1_3'UTR			Q96Q89	KI20B_HUMAN	kinesin family member 20B	1755	Interaction with PIN1.				cell cycle arrest|cell division|microtubule-based movement|mitosis|regulation of mitosis	centrosome|microtubule|nucleolus|nucleoplasm|spindle	ATP binding|ATPase activity|microtubule motor activity|WW domain binding			endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(20)|lung(15)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)	58						AATTGAAACAATGAGCTCTTC	0.299000													3	58					0	0	1	0	0
NEU1	4758	broad.mit.edu	37	6	31828334	31828334	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-AAN4-01A-11D-A42E-08	TCGA-XF-AAN4-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ef58d603-784f-406e-b97d-ab2ce298601d	a06ce9e1-7c84-4520-aa93-bedc1d91a0f6	g.chr6:31828334C>G	ENST00000375631.4	-	4	809	c.680G>C	c.(679-681)gGa>gCa	p.G227A		NM_000434.3	NP_000425.1	Q99519	NEUR1_HUMAN	sialidase 1 (lysosomal sialidase)	227			G -> R (in SIALIDOSIS; type 1 and juvenile type 2; catalytically inactive; retained in pre-lysosomal compartments).			cytoplasmic membrane-bounded vesicle|lysosomal lumen|lysosomal membrane|plasma membrane	exo-alpha-sialidase activity|protein binding			kidney(1)|large_intestine(1)|lung(6)|ovary(1)|prostate(1)	10					Oseltamivir(DB00198)|Zanamivir(DB00558)	ACAGAAGACTCCGTCCCGCTC	0.607000													3	65					0	0	1	0	0
IGSF1	3547	broad.mit.edu	37	X	130419396	130419396	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-AAN4-01A-11D-A42E-08	TCGA-XF-AAN4-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ef58d603-784f-406e-b97d-ab2ce298601d	a06ce9e1-7c84-4520-aa93-bedc1d91a0f6	g.chrX:130419396C>T	ENST00000370904.1	-	11	1307	c.397G>A	c.(397-399)Gct>Act	p.A133T	IGSF1_ENST00000370900.1_Missense_Mutation_p.A142T|IGSF1_ENST00000361420.3_Missense_Mutation_p.A142T|IGSF1_ENST00000370903.3_Missense_Mutation_p.A142T|IGSF1_ENST00000370910.1_Missense_Mutation_p.A133T|IGSF1_ENST00000370901.4_Missense_Mutation_p.A142T			Q8N6C5	IGSF1_HUMAN	immunoglobulin superfamily, member 1	142					regulation of transcription, DNA-dependent	extracellular region|integral to membrane	inhibin beta-A binding|inhibin beta-B binding			breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(15)|liver(1)|lung(37)|ovary(4)|skin(3)|upper_aerodigestive_tract(2)	78						CCAGGAAGAGCGGGGGTCTCA	0.488000													4	62					0	0	1	0	0
C9orf163	158055	broad.mit.edu	37	9	139379239	139379239	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-AAN4-01A-11D-A42E-08	TCGA-XF-AAN4-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ef58d603-784f-406e-b97d-ab2ce298601d	a06ce9e1-7c84-4520-aa93-bedc1d91a0f6	g.chr9:139379239G>C	ENST00000354376.1	+	1	1293	c.339G>C	c.(337-339)ttG>ttC	p.L113F		NM_152571.2	NP_689784.1	Q8N9P6	CI163_HUMAN	chromosome 9 open reading frame 163	113							protein binding			kidney(1)|lung(1)	2		Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;4.36e-06)|Epithelial(140;5.65e-06)		TGACCTGTTTGAACAGAGTTA	0.622000											OREG0019617	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	5	43					0	0	1	0	0
FAM208B	54906	broad.mit.edu	37	10	5772737	5772737	+	Nonsense_Mutation	SNP	C	C	T			TCGA-XF-AAN4-01A-11D-A42E-08	TCGA-XF-AAN4-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ef58d603-784f-406e-b97d-ab2ce298601d	a06ce9e1-7c84-4520-aa93-bedc1d91a0f6	g.chr10:5772737C>T	ENST00000328090.5	+	11	1400	c.775C>T	c.(775-777)Cag>Tag	p.Q259*	RP11-336A10.2_ENST00000411512.2_RNA	NM_017782.4	NP_060252	Q5VWN6	CJ018_HUMAN	family with sequence similarity 208, member B	259																	GTCTTTAACTCAGTTGAACTC	0.438000													5	152					0	0	1	0	0
IGHV1-46	28465	broad.mit.edu	37	14	106967158	106967158	+	RNA	SNP	T	T	C			TCGA-XF-AAN4-01A-11D-A42E-08	TCGA-XF-AAN4-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ef58d603-784f-406e-b97d-ab2ce298601d	a06ce9e1-7c84-4520-aa93-bedc1d91a0f6	g.chr14:106967158T>C	ENST00000390622.2	-	0	545																											CTGGAACTTCTGTGCGTAGCT	0.552000													10	208					0	0	1	0	0
APLP1	333	broad.mit.edu	37	19	36365448	36365448	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-AAN4-01A-11D-A42E-08	TCGA-XF-AAN4-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ef58d603-784f-406e-b97d-ab2ce298601d	a06ce9e1-7c84-4520-aa93-bedc1d91a0f6	g.chr19:36365448G>A	ENST00000221891.4	+	9	1291	c.1099G>A	c.(1099-1101)Ggt>Agt	p.G367S	APLP1_ENST00000537454.2_Missense_Mutation_p.G328S|APLP1_ENST00000589298.2_3'UTR|APLP1_ENST00000586861.1_Missense_Mutation_p.G361S	NM_001024807.1|NM_005166.3	NP_001019978.1|NP_005157.1	P51693	APLP1_HUMAN	amyloid beta (A4) precursor-like protein 1	367					apoptosis|cell adhesion|cellular response to norepinephrine stimulus|endocytosis|negative regulation of cAMP biosynthetic process|nervous system development|organ morphogenesis	basement membrane|integral to membrane|perinuclear region of cytoplasm|plasma membrane	alpha-2A adrenergic receptor binding|alpha-2B adrenergic receptor binding|alpha-2C adrenergic receptor binding|heparin binding|identical protein binding|metal ion binding			breast(4)|endometrium(2)|kidney(2)|large_intestine(12)|liver(1)|lung(9)|ovary(2)|upper_aerodigestive_tract(1)	33	all_lung(56;7.14e-07)|Lung NSC(56;1.12e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			GCAGGTGTCTGGTGAGCGACA	0.637000													5	71					0	0	1	0	0
ATRX	546	broad.mit.edu	37	X	76937182	76937182	+	Missense_Mutation	SNP	A	A	G			TCGA-XF-AAN4-01A-11D-A42E-08	TCGA-XF-AAN4-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ef58d603-784f-406e-b97d-ab2ce298601d	a06ce9e1-7c84-4520-aa93-bedc1d91a0f6	g.chrX:76937182A>G	ENST00000373344.5	-	9	3780	c.3566T>C	c.(3565-3567)cTa>cCa	p.L1189P	ATRX_ENST00000395603.3_Missense_Mutation_p.L1151P|ATRX_ENST00000480283.1_5'UTR	NM_000489.3	NP_000480.3	P46100	ATRX_HUMAN	alpha thalassemia/mental retardation syndrome X-linked	1189					DNA methylation|DNA recombination|DNA repair|regulation of transcription, DNA-dependent	nuclear heterochromatin	ATP binding|chromo shadow domain binding|DNA binding|DNA helicase activity|zinc ion binding	p.?(1)		bone(1)|breast(6)|central_nervous_system(31)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(15)|kidney(14)|large_intestine(1)|liver(1)|lung(40)|ovary(2)|pancreas(13)|prostate(5)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	145					Phosphatidylserine(DB00144)	GCTTGTTCTTAGGGAGTTTCT	0.373000			"""Mis, F, N"""		"""Pancreatic neuroendocrine tumors, paediatric GBM"""		ATR-X (alpha thalassemia/mental retardation) syndrome						4	235					0	0	1	0	0
PCDHB4	56131	broad.mit.edu	37	5	140502691	140502691	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-AAN4-01A-11D-A42E-08	TCGA-XF-AAN4-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ef58d603-784f-406e-b97d-ab2ce298601d	a06ce9e1-7c84-4520-aa93-bedc1d91a0f6	g.chr5:140502691G>C	ENST00000194152.1	+	1	1111	c.1111G>C	c.(1111-1113)Gat>Cat	p.D371H		NM_018938.2	NP_061761.1	Q9Y5E5	PCDB4_HUMAN		371	Cadherin 4.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	cytoplasm|integral to plasma membrane|intermediate filament cytoskeleton	calcium ion binding			autonomic_ganglia(1)|breast(2)|endometrium(4)|kidney(2)|large_intestine(12)|lung(35)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	67			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CCGAATTCGAGATAGAGATTC	0.403000													6	136					0	0	1	0	0
IRF3	3661	broad.mit.edu	37	19	50165493	50165493	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-AAN4-01A-11D-A42E-08	TCGA-XF-AAN4-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ef58d603-784f-406e-b97d-ab2ce298601d	a06ce9e1-7c84-4520-aa93-bedc1d91a0f6	g.chr19:50165493C>T	ENST00000597198.1	-	6	1075	c.694G>A	c.(694-696)Gaa>Aaa	p.E232K	IRF3_ENST00000599144.1_Missense_Mutation_p.E86K|IRF3_ENST00000377139.3_Missense_Mutation_p.E232K|IRF3_ENST00000599223.1_Intron|IRF3_ENST00000601291.1_Missense_Mutation_p.E232K|IRF3_ENST00000593922.1_Missense_Mutation_p.E86K|IRF3_ENST00000596822.1_Intron|IRF3_ENST00000377135.4_Intron|IRF3_ENST00000596765.1_Intron|IRF3_ENST00000600911.1_Missense_Mutation_p.E232K|IRF3_ENST00000598808.1_Missense_Mutation_p.E86K|IRF3_ENST00000600022.1_Intron|IRF3_ENST00000309877.7_Missense_Mutation_p.E232K			Q14653	IRF3_HUMAN	interferon regulatory factor 3	232	Involved in HERC5 binding.				interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|MyD88-independent toll-like receptor signaling pathway|negative regulation of type I interferon production|response to virus|Toll signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|transcription from RNA polymerase II promoter|type I interferon-mediated signaling pathway	cytosol|endosome membrane|nucleoplasm|plasma membrane	DNA binding|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|transcription cofactor activity			breast(1)|large_intestine(2)|lung(4)|ovary(2)|stomach(1)	10		all_lung(116;3.24e-07)|Lung NSC(112;1.6e-06)|all_neural(266;0.0459)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.0011)|GBM - Glioblastoma multiforme(134;0.02)		TCTCCCACTTCGGACCCCACC	0.637000													3	35					0	0	1	0	0
XIST	7503	broad.mit.edu	37	X	73065052	73065052	+	RNA	SNP	G	G	C			TCGA-XF-AAN4-01A-11D-A42E-08	TCGA-XF-AAN4-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ef58d603-784f-406e-b97d-ab2ce298601d	a06ce9e1-7c84-4520-aa93-bedc1d91a0f6	g.chrX:73065052G>C	ENST00000429829.1	-	0	7536					NR_001564.2																						GGGAAAGGAAGATTGGGGGTG	0.498000													6	103					0	0	1	0	0
OR10K1	391109	broad.mit.edu	37	1	158435547	158435547	+	Missense_Mutation	SNP	C	C	A			TCGA-XF-AAN4-01A-11D-A42E-08	TCGA-XF-AAN4-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ef58d603-784f-406e-b97d-ab2ce298601d	a06ce9e1-7c84-4520-aa93-bedc1d91a0f6	g.chr1:158435547C>A	ENST00000289451.2	+	1	276	c.196C>A	c.(196-198)Ctt>Att	p.L66I		NM_001004473.1	NP_001004473.1	Q8NGX5	O10K1_HUMAN	olfactory receptor, family 10, subfamily K, member 1	66					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(1)|lung(15)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|stomach(1)	27	all_hematologic(112;0.0378)					CCTTGCCATCCTTTCTTGCTC	0.483000													4	77					0.00909568	0.00967626	1	1	0
TENM2	57451	broad.mit.edu	37	5	167545377	167545377	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-AAN4-01A-11D-A42E-08	TCGA-XF-AAN4-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ef58d603-784f-406e-b97d-ab2ce298601d	a06ce9e1-7c84-4520-aa93-bedc1d91a0f6	g.chr5:167545377G>C	ENST00000519204.1	+	9	1649	c.1531G>C	c.(1531-1533)Gag>Cag	p.E511Q	CTB-178M22.1_ENST00000517408.1_RNA|TENM2_ENST00000545108.1_Missense_Mutation_p.E632Q|TENM2_ENST00000403607.2_Missense_Mutation_p.E465Q|TENM2_ENST00000518659.1_Missense_Mutation_p.E632Q|TENM2_ENST00000520394.1_Missense_Mutation_p.E400Q					teneurin transmembrane protein 2																		GAAAGGTGCAGAGTGCGACGT	0.567000													5	111					0	0	1	0	0
RGPD8	727851	broad.mit.edu	37	2	113127775	113127775	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-AAN4-01A-11D-A42E-08	TCGA-XF-AAN4-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ef58d603-784f-406e-b97d-ab2ce298601d	a06ce9e1-7c84-4520-aa93-bedc1d91a0f6	g.chr2:113127775G>C	ENST00000302558.3	-	23	5469	c.5278C>G	c.(5278-5280)Cct>Gct	p.P1760A	RGPD8_ENST00000409750.1_Missense_Mutation_p.P1620A	NM_001164463.1	NP_001157935.1			RANBP2-like and GRIP domain containing 8									p.P1760A(12)		endometrium(4)|kidney(1)|lung(1)|prostate(3)|urinary_tract(1)	10						GAACGGGAAGGATTTTCTTCC	0.308000													3	71					0	0	1	0	0
ZNF433	163059	broad.mit.edu	37	19	12125856	12125856	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-AAN4-01A-11D-A42E-08	TCGA-XF-AAN4-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ef58d603-784f-406e-b97d-ab2ce298601d	a06ce9e1-7c84-4520-aa93-bedc1d91a0f6	g.chr19:12125856C>G	ENST00000419886.2	-	5	2012	c.1721G>C	c.(1720-1722)gGa>gCa	p.G574A	ZNF433_ENST00000344980.6_Missense_Mutation_p.G609A|CTD-2006C1.2_ENST00000406892.2_RNA|CTD-2006C1.2_ENST00000495324.1_RNA|CTD-2006C1.2_ENST00000476474.1_RNA			Q8N7K0	ZN433_HUMAN	zinc finger protein 433	609					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(2)|endometrium(3)|kidney(1)|large_intestine(4)|lung(1)|prostate(1)|skin(1)	14						GTGAGTCCTTCCATGCATTTG	0.468000													4	118					0	0	1	0	0
PSMC4	5704	broad.mit.edu	37	19	40486588	40486588	+	Silent	SNP	G	G	A			TCGA-XF-AAN4-01A-11D-A42E-08	TCGA-XF-AAN4-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ef58d603-784f-406e-b97d-ab2ce298601d	a06ce9e1-7c84-4520-aa93-bedc1d91a0f6	g.chr19:40486588G>A	ENST00000157812.2	+	10	1305	c.1107G>A	c.(1105-1107)aaG>aaA	p.K369K	PSMC4_ENST00000455878.2_Silent_p.K338K	NM_006503.3|NM_153001.2	NP_006494.1|NP_694546.1	P43686	PRS6B_HUMAN	proteasome (prosome, macropain) 26S subunit, ATPase, 4	369					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	mitochondrion|nucleus|proteasome complex	ATP binding|ATPase activity|protein binding			autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(2)|large_intestine(3)|lung(7)|ovary(1)|prostate(2)|urinary_tract(1)	19	all_cancers(60;9.55e-06)|all_lung(34;1.17e-07)|Lung NSC(34;1.41e-07)|Ovarian(47;0.0925)					GGCCAGATAAGATTTCAGGAG	0.512000													5	74					0	0	1	0	0
SEMA3C	10512	broad.mit.edu	37	7	80374354	80374354	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-AAN4-01A-11D-A42E-08	TCGA-XF-AAN4-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ef58d603-784f-406e-b97d-ab2ce298601d	a06ce9e1-7c84-4520-aa93-bedc1d91a0f6	g.chr7:80374354C>T	ENST00000265361.3	-	18	2673	c.2112G>A	c.(2110-2112)atG>atA	p.M704I	SEMA3C_ENST00000419255.2_Missense_Mutation_p.M704I|SEMA3C_ENST00000544525.1_Missense_Mutation_p.M722I	NM_006379.3	NP_006370.1	Q99985	SEM3C_HUMAN	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C	704					immune response|response to drug	membrane	receptor activity			NS(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(17)|ovary(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	34						ATTGGTTAATCATCTGCATTT	0.502000													9	91					0	0	1	0	0
TIMP2	7077	broad.mit.edu	37	17	76851817	76851817	+	Missense_Mutation	SNP	C	C	A			TCGA-XF-AAN4-01A-11D-A42E-08	TCGA-XF-AAN4-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ef58d603-784f-406e-b97d-ab2ce298601d	a06ce9e1-7c84-4520-aa93-bedc1d91a0f6	g.chr17:76851817C>A	ENST00000262768.7	-	5	893	c.595G>T	c.(595-597)Ggc>Tgc	p.G199C	TIMP2_ENST00000536189.2_Missense_Mutation_p.G122C|TIMP2_ENST00000585421.1_Missense_Mutation_p.G122C|TIMP2_ENST00000586057.1_Missense_Mutation_p.G122C|RP11-323N12.5_ENST00000587434.1_RNA	NM_003255.4	NP_003246.1	P16035	TIMP2_HUMAN	TIMP metallopeptidase inhibitor 2	199							metal ion binding|metalloendopeptidase inhibitor activity			central_nervous_system(2)	2			BRCA - Breast invasive adenocarcinoma(99;0.0101)|OV - Ovarian serous cystadenocarcinoma(97;0.194)			GCACAGGAGCCGTCACTTCTC	0.622000													3	45					0.004672	0.00502366	1	1	0
SDHAP1	255812	broad.mit.edu	37	3	195701278	195701278	+	RNA	SNP	C	C	T			TCGA-XF-AAN4-01A-11D-A42E-08	TCGA-XF-AAN4-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ef58d603-784f-406e-b97d-ab2ce298601d	a06ce9e1-7c84-4520-aa93-bedc1d91a0f6	g.chr3:195701278C>T	ENST00000427841.1	-	0	1546					NR_003264.2																						CAGGCCTGCACGACTCTGCGA	0.537000													4	34					0	0	1	0	0
GNPAT	8443	broad.mit.edu	37	1	231402124	231402124	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-AAN4-01A-11D-A42E-08	TCGA-XF-AAN4-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ef58d603-784f-406e-b97d-ab2ce298601d	a06ce9e1-7c84-4520-aa93-bedc1d91a0f6	g.chr1:231402124G>A	ENST00000366647.4	+	8	1195	c.1026G>A	c.(1024-1026)atG>atA	p.M342I	GNPAT_ENST00000366646.3_Missense_Mutation_p.M281I	NM_014236.3	NP_055051.1	O15228	GNPAT_HUMAN	glyceronephosphate O-acyltransferase	342					ether lipid biosynthetic process|fatty acid metabolic process|organ morphogenesis	peroxisomal matrix|peroxisomal membrane	glycerone-phosphate O-acyltransferase activity			breast(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(9)|ovary(3)|prostate(1)|skin(1)	23	Breast(184;0.0871)	all_cancers(173;0.2)|Prostate(94;0.183)				CTGGGAGGATGAGTCGGAGCT	0.428000													5	59					0	0	1	0	0
LINGO2	158038	broad.mit.edu	37	9	27948941	27948941	+	Missense_Mutation	SNP	T	T	C			TCGA-XF-AAN4-01A-11D-A42E-08	TCGA-XF-AAN4-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ef58d603-784f-406e-b97d-ab2ce298601d	a06ce9e1-7c84-4520-aa93-bedc1d91a0f6	g.chr9:27948941T>C	ENST00000379992.2	-	6	2178	c.1729A>G	c.(1729-1731)Att>Gtt	p.I577V	LINGO2_ENST00000308675.3_Missense_Mutation_p.I577V	NM_152570.2	NP_689783.1	Q7L985	LIGO2_HUMAN	leucine rich repeat and Ig domain containing 2	577						integral to membrane				autonomic_ganglia(1)|breast(2)|central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|liver(1)|lung(13)|ovary(2)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)	44	Melanoma(11;0.242)	all_neural(11;2.78e-09)		UCEC - Uterine corpus endometrioid carcinoma (5;0.0818)|GBM - Glioblastoma multiforme(2;1.31e-34)|all cancers(2;2.37e-25)|Lung(2;7.48e-08)|LUSC - Lung squamous cell carcinoma(38;5.09e-07)|KIRC - Kidney renal clear cell carcinoma(2;0.0465)|Kidney(2;0.0604)		TCAAGGTCAATGCTGTTTTTG	0.468000													9	69					0	0	1	0	0
UBA2	10054	broad.mit.edu	37	19	34942935	34942935	+	Silent	SNP	G	G	A			TCGA-XF-AAN4-01A-11D-A42E-08	TCGA-XF-AAN4-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ef58d603-784f-406e-b97d-ab2ce298601d	a06ce9e1-7c84-4520-aa93-bedc1d91a0f6	g.chr19:34942935G>A	ENST00000439527.2	+	10	1131	c.633G>A	c.(631-633)ctG>ctA	p.L211L	UBA2_ENST00000246548.4_Silent_p.L307L			Q9UBT2	SAE2_HUMAN	ubiquitin-like modifier activating enzyme 2	307					protein sumoylation	nucleus	ATP binding|enzyme activator activity|ligase activity|metal ion binding|protein heterodimerization activity|SUMO activating enzyme activity			breast(2)|endometrium(5)|kidney(1)|large_intestine(5)|lung(5)|ovary(1)|upper_aerodigestive_tract(1)	20	Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.211)			AGTTAGGCCTGAAAGACCAGC	0.373000													4	70					0	0	1	0	0
UNC13A	23025	broad.mit.edu	37	19	17741479	17741479	+	Missense_Mutation	SNP	C	C	A			TCGA-XF-AAN4-01A-11D-A42E-08	TCGA-XF-AAN4-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ef58d603-784f-406e-b97d-ab2ce298601d	a06ce9e1-7c84-4520-aa93-bedc1d91a0f6	g.chr19:17741479C>A	ENST00000428389.2	-	30	3772	c.3773G>T	c.(3772-3774)cGa>cTa	p.R1258L	UNC13A_ENST00000552293.1_Missense_Mutation_p.R1170L|UNC13A_ENST00000551649.1_Missense_Mutation_p.R1170L|UNC13A_ENST00000252773.7_Missense_Mutation_p.R1170L|UNC13A_ENST00000550896.1_Missense_Mutation_p.R1168L|UNC13A_ENST00000519716.2_Missense_Mutation_p.R1170L			Q9UPW8	UN13A_HUMAN	unc-13 homolog A (C. elegans)	1170					exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			breast(2)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(11)|lung(31)|ovary(5)|prostate(2)	61						CTTCTTGTCTCGCTCCAGGGC	0.542000													3	49					2.56e-06	2.8764e-06	1	1	0
FAM73B	84895	broad.mit.edu	37	9	131832211	131832211	+	Missense_Mutation	SNP	G	G	T			TCGA-XF-AAN4-01A-11D-A42E-08	TCGA-XF-AAN4-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ef58d603-784f-406e-b97d-ab2ce298601d	a06ce9e1-7c84-4520-aa93-bedc1d91a0f6	g.chr9:131832211G>T	ENST00000358369.4	+	15	1768	c.1542G>T	c.(1540-1542)aaG>aaT	p.K514N	FAM73B_ENST00000277475.5_3'UTR|FAM73B_ENST00000406926.2_3'UTR	NM_032809.2	NP_116198.2	Q7L4E1	FA73B_HUMAN	family with sequence similarity 73, member B	514						integral to membrane				breast(1)|endometrium(2)|large_intestine(2)|lung(7)|skin(1)	13						TTGGACCCAAGCCTCAGCTTG	0.572000													6	185					0.0293803	0.0299799	1	1	0
BCAP29	55973	broad.mit.edu	37	7	107221229	107221229	+	Silent	SNP	A	A	G	rs79851050	by1000genomes	TCGA-XF-AAN4-01A-11D-A42E-08	TCGA-XF-AAN4-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ef58d603-784f-406e-b97d-ab2ce298601d	a06ce9e1-7c84-4520-aa93-bedc1d91a0f6	g.chr7:107221229A>G	ENST00000379119.2	+	1	26	c.12A>G	c.(10-12)caA>caG	p.Q4Q	BCAP29_ENST00000494086.1_Intron|BCAP29_ENST00000379117.2_Silent_p.Q4Q|BCAP29_ENST00000445771.2_Silent_p.Q4Q|BCAP29_ENST00000005259.4_Silent_p.Q4Q|BCAP29_ENST00000465919.1_Intron	NM_001008405.2	NP_001008405.1	Q9UHQ4	BAP29_HUMAN	B-cell receptor-associated protein 29	4					apoptosis|intracellular protein transport|vesicle-mediated transport	endoplasmic reticulum membrane|integral to membrane				cervix(1)|kidney(1)|large_intestine(4)|lung(4)|ovary(2)|skin(1)|urinary_tract(1)	14						TGACACTCCAATGGGCTGCAG	0.428000													3	48					0	0	1	0	0
EIF4G1	1981	broad.mit.edu	37	3	184043702	184043702	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-AAN4-01A-11D-A42E-08	TCGA-XF-AAN4-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ef58d603-784f-406e-b97d-ab2ce298601d	a06ce9e1-7c84-4520-aa93-bedc1d91a0f6	g.chr3:184043702G>A	ENST00000342981.4	+	20	3602	c.3188G>A	c.(3187-3189)cGc>cAc	p.R1063H	EIF4G1_ENST00000350481.5_Missense_Mutation_p.R898H|EIF4G1_ENST00000424196.1_Missense_Mutation_p.R1069H|EIF4G1_ENST00000411531.1_Missense_Mutation_p.R1023H|EIF4G1_ENST00000392537.2_Missense_Mutation_p.R975H|EIF4G1_ENST00000319274.6_Missense_Mutation_p.R1062H|EIF4G1_ENST00000414031.1_Missense_Mutation_p.R1022H|EIF4G1_ENST00000352767.3_Missense_Mutation_p.R1069H|EIF4G1_ENST00000427845.1_Missense_Mutation_p.R976H|EIF2B5_ENST00000444495.1_Intron|EIF4G1_ENST00000346169.2_Missense_Mutation_p.R1062H|EIF4G1_ENST00000382330.3_Missense_Mutation_p.R1069H|EIF4G1_ENST00000435046.2_Missense_Mutation_p.R866H|EIF4G1_ENST00000434061.2_Missense_Mutation_p.R867H|EIF4G1_ENST00000441154.1_Missense_Mutation_p.R899H	NM_182917.4	NP_886553	Q04637	IF4G1_HUMAN	eukaryotic translation initiation factor 4 gamma, 1	1062	eIF3/EIF4A-binding.				insulin receptor signaling pathway|interspecies interaction between organisms|nuclear-transcribed mRNA poly(A) tail shortening|regulation of translational initiation	cytosol|eukaryotic translation initiation factor 4F complex	protein binding|translation initiation factor activity			central_nervous_system(1)|cervix(2)|endometrium(3)|kidney(5)|large_intestine(14)|lung(41)|ovary(2)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	75	all_cancers(143;1.06e-10)|Ovarian(172;0.0339)		Epithelial(37;1.53e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			AAAGGTAGCCGCCCCATTGAC	0.507000													5	139					0	0	1	0	0
LRRC37A16P	651250	broad.mit.edu	37	17	66126418	66126418	+	RNA	SNP	A	A	G			TCGA-XF-AAN4-01A-11D-A42E-08	TCGA-XF-AAN4-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ef58d603-784f-406e-b97d-ab2ce298601d	a06ce9e1-7c84-4520-aa93-bedc1d91a0f6	g.chr17:66126418A>G	ENST00000590019.1	-	0	343																											CCTCAATGCTATTTTTAAATT	0.413000													4	284					0	0	1	0	0
RAD21	5885	broad.mit.edu	37	8	117862949	117862949	+	Missense_Mutation	SNP	G	G	T			TCGA-XF-AAN4-01A-11D-A42E-08	TCGA-XF-AAN4-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ef58d603-784f-406e-b97d-ab2ce298601d	a06ce9e1-7c84-4520-aa93-bedc1d91a0f6	g.chr8:117862949G>T	ENST00000297338.2	-	12	1815	c.1528C>A	c.(1528-1530)Cca>Aca	p.P510T	RAD21_ENST00000523986.1_Missense_Mutation_p.P14T|RAD21_ENST00000518055.1_Missense_Mutation_p.P55T	NM_006265.2	NP_006256.1	O60216	RAD21_HUMAN	RAD21 homolog (S. pombe)	510	Pro-rich.				apoptosis|cell division|chromosome segregation|double-strand break repair|mitotic metaphase/anaphase transition|mitotic prometaphase|protein localization to chromatin|reciprocal meiotic recombination|regulation of transcription from RNA polymerase II promoter	chromosome, centromeric region|cohesin complex|nuclear chromosome|nucleoplasm	protein binding	p.P510T(1)		endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(16)|ovary(1)|prostate(1)|skin(1)|stomach(1)	32	all_cancers(13;1.21e-21)|Lung NSC(37;0.000134)|Ovarian(258;0.0172)					CAGATATTTGGAGGTTCTTCT	0.383000													4	78					0.150653	0.152175	1	1	0
NKRF	55922	broad.mit.edu	37	X	118723504	118723504	+	Silent	SNP	C	C	T			TCGA-XF-AAN4-01A-11D-A42E-08	TCGA-XF-AAN4-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ef58d603-784f-406e-b97d-ab2ce298601d	a06ce9e1-7c84-4520-aa93-bedc1d91a0f6	g.chrX:118723504C>T	ENST00000371527.1	-	2	2536	c.1884G>A	c.(1882-1884)ctG>ctA	p.L628L	NKRF_ENST00000304449.5_Silent_p.L628L|NKRF_ENST00000487600.1_Intron|NKRF_ENST00000542113.1_Silent_p.L643L	NM_001173488.1	NP_001166959.1	O15226	NKRF_HUMAN	NFKB repressing factor	628	R3H.				negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|double-stranded RNA binding			breast(1)|central_nervous_system(1)|endometrium(8)|kidney(3)|large_intestine(2)|lung(9)|ovary(1)|prostate(3)|skin(1)|urinary_tract(1)	30						CATCATTAGTCAGCTCTCTAG	0.443000													5	112					0	0	1	0	0
PCDHGA2	56113	broad.mit.edu	37	5	140719675	140719675	+	Silent	SNP	C	C	T			TCGA-XF-AAN4-01A-11D-A42E-08	TCGA-XF-AAN4-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ef58d603-784f-406e-b97d-ab2ce298601d	a06ce9e1-7c84-4520-aa93-bedc1d91a0f6	g.chr5:140719675C>T	ENST00000394576.2	+	1	1137	c.1137C>T	c.(1135-1137)aaC>aaT	p.N379N	PCDHGA1_ENST00000517417.1_Intron	NM_018915.2	NP_061738.1														breast(3)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(20)|lung(32)|ovary(1)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	77			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTGGGCAGAACGCATTCACCA	0.433000													4	136					0	0	1	0	0
RNF220	55182	broad.mit.edu	37	1	44878061	44878061	+	Nonsense_Mutation	SNP	C	C	T			TCGA-XF-AAN4-01A-11D-A42E-08	TCGA-XF-AAN4-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ef58d603-784f-406e-b97d-ab2ce298601d	a06ce9e1-7c84-4520-aa93-bedc1d91a0f6	g.chr1:44878061C>T	ENST00000355387.2	+	2	742	c.292C>T	c.(292-294)Caa>Taa	p.Q98*	RNF220_ENST00000372247.2_Nonsense_Mutation_p.Q98*|RNF220_ENST00000361799.2_Nonsense_Mutation_p.Q98*			Q5VTB9	RN220_HUMAN	ring finger protein 220	98					protein autoubiquitination	cytoplasm	ubiquitin-protein ligase activity|zinc ion binding			endometrium(6)|kidney(1)|large_intestine(3)|lung(13)|ovary(2)|skin(2)|urinary_tract(2)	29						CCTCCACCCTCAATTTGCTCC	0.547000													5	132					0	0	1	0	0
ADGRE4P	326342	broad.mit.edu	37	19	6988808	6988808	+	RNA	SNP	C	C	T			TCGA-XF-AAN4-01A-11D-A42E-08	TCGA-XF-AAN4-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ef58d603-784f-406e-b97d-ab2ce298601d	a06ce9e1-7c84-4520-aa93-bedc1d91a0f6	g.chr19:6988808C>T	ENST00000600751.1	-	0	122					NR_024075.1																						CTCCAGAATTCTTGGCTTCTG	0.522000													3	45					0	0	1	0	0
CPT1A	1374	broad.mit.edu	37	11	68529087	68529087	+	Missense_Mutation	SNP	C	C	A			TCGA-XF-AAN4-01A-11D-A42E-08	TCGA-XF-AAN4-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ef58d603-784f-406e-b97d-ab2ce298601d	a06ce9e1-7c84-4520-aa93-bedc1d91a0f6	g.chr11:68529087C>A	ENST00000265641.5	-	16	2098	c.1944G>T	c.(1942-1944)atG>atT	p.M648I	CPT1A_ENST00000376618.2_Missense_Mutation_p.M648I|CPT1A_ENST00000540367.1_Missense_Mutation_p.M648I|CPT1A_ENST00000539743.1_Missense_Mutation_p.M648I	NM_001876.3	NP_001867.2	P50416	CPT1A_HUMAN	carnitine palmitoyltransferase 1A (liver)	648					carnitine shuttle|fatty acid beta-oxidation	integral to membrane|mitochondrial outer membrane	carnitine O-palmitoyltransferase activity			NS(2)|breast(1)|endometrium(2)|kidney(1)|large_intestine(7)|liver(1)|lung(17)|ovary(3)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	42	Esophageal squamous(3;3.28e-14)		LUAD - Lung adenocarcinoma(13;0.0676)|STAD - Stomach adenocarcinoma(18;0.142)		L-Carnitine(DB00583)|Perhexiline(DB01074)	CAGAGCCGGTCATGGCGAGGC	0.493000													8	110					0.00448238	0.00487215	1	1	0
MAGEA12	4111	broad.mit.edu	37	X	151900595	151900595	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-AAN4-01A-11D-A42E-08	TCGA-XF-AAN4-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ef58d603-784f-406e-b97d-ab2ce298601d	a06ce9e1-7c84-4520-aa93-bedc1d91a0f6	g.chrX:151900595G>A	ENST00000393900.3	-	3	559	c.206C>T	c.(205-207)tCc>tTc	p.S69F	MAGEA12_ENST00000357916.4_Missense_Mutation_p.S69F|CSAG4_ENST00000361201.4_RNA|MAGEA12_ENST00000393869.3_Missense_Mutation_p.S69F	NM_001166386.1	NP_001159858.1	P43365	MAGAC_HUMAN	melanoma antigen family A, 12	69										breast(5)|large_intestine(5)|liver(1)|lung(14)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	28	Acute lymphoblastic leukemia(192;6.56e-05)					GGGGAGGGTGGAGGCTCCCTG	0.592000													6	100					0	0	1	0	0
ADAMTS8	11095	broad.mit.edu	37	11	130275620	130275620	+	Nonsense_Mutation	SNP	G	G	A			TCGA-XF-AAN4-01A-11D-A42E-08	TCGA-XF-AAN4-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ef58d603-784f-406e-b97d-ab2ce298601d	a06ce9e1-7c84-4520-aa93-bedc1d91a0f6	g.chr11:130275620G>A	ENST00000257359.6	-	9	3209	c.2503C>T	c.(2503-2505)Cag>Tag	p.Q835*		NM_007037.4	NP_008968.4	Q9UP79	ATS8_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 8	835	TSP type-1 2.				negative regulation of cell proliferation|proteolysis	proteinaceous extracellular matrix	heparin binding|integrin binding|low affinity phosphate transmembrane transporter activity|metalloendopeptidase activity|zinc ion binding			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(2)|prostate(1)|skin(1)	10	all_hematologic(175;0.0429)	Lung NSC(97;0.000601)|Breast(109;0.000962)|all_lung(97;0.00125)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.039)|Lung(977;0.213)		AGCACCCACTGTGCGTGGAGC	0.592000													4	74					0	0	1	0	0
SPG7	6687	broad.mit.edu	37	16	89590650	89590650	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-AAN4-01A-11D-A42E-08	TCGA-XF-AAN4-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ef58d603-784f-406e-b97d-ab2ce298601d	a06ce9e1-7c84-4520-aa93-bedc1d91a0f6	g.chr16:89590650C>T	ENST00000268704.2	+	4	628	c.613C>T	c.(613-615)Cgg>Tgg	p.R205W	SPG7_ENST00000341316.2_Missense_Mutation_p.R205W	NM_003119.2	NP_003110.1	Q9UQ90	SPG7_HUMAN	spastic paraplegia 7 (pure and complicated autosomal recessive)	205					cell death|nervous system development|protein catabolic process|proteolysis	integral to membrane|mitochondrial membrane	ATP binding|metalloendopeptidase activity|nucleoside-triphosphatase activity|unfolded protein binding|zinc ion binding			autonomic_ganglia(1)|breast(2)|endometrium(2)|kidney(1)|large_intestine(4)|lung(7)|ovary(2)|urinary_tract(1)	20		all_hematologic(23;0.00824)|Colorectal(91;0.102)		all cancers(4;1.39e-07)|OV - Ovarian serous cystadenocarcinoma(4;5.64e-06)|BRCA - Breast invasive adenocarcinoma(80;0.015)		GGTGTTTGGGCGGCCTGTGAG	0.657000													4	127					0	0	1	0	0
PCOLCE2	26577	broad.mit.edu	37	3	142542431	142542431	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-AAN4-01A-11D-A42E-08	TCGA-XF-AAN4-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ef58d603-784f-406e-b97d-ab2ce298601d	a06ce9e1-7c84-4520-aa93-bedc1d91a0f6	g.chr3:142542431G>C	ENST00000295992.3	-	7	1198	c.892C>G	c.(892-894)Caa>Gaa	p.Q298E	PCOLCE2_ENST00000485766.1_Intron	NM_013363.3	NP_037495.1	Q9UKZ9	PCOC2_HUMAN	procollagen C-endopeptidase enhancer 2	298	NTR.					extracellular region	collagen binding|heparin binding|peptidase activator activity			NS(1)|endometrium(1)|large_intestine(11)|lung(15)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	32						CACTTTTGTTGACACAAGGCC	0.378000													4	133					0	0	1	0	0
TAF1B	9014	broad.mit.edu	37	2	10016135	10016135	+	Nonsense_Mutation	SNP	C	C	G			TCGA-XF-AAN4-01A-11D-A42E-08	TCGA-XF-AAN4-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ef58d603-784f-406e-b97d-ab2ce298601d	a06ce9e1-7c84-4520-aa93-bedc1d91a0f6	g.chr2:10016135C>G	ENST00000263663.5	+	7	883	c.695C>G	c.(694-696)tCa>tGa	p.S232*	TAF1B_ENST00000396242.3_Intron	NM_005680.2	NP_005671	Q53T94	TAF1B_HUMAN	TATA box binding protein (TBP)-associated factor, RNA polymerase I, B, 63kDa	232					termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription initiation from RNA polymerase I promoter	nucleoplasm	DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(1)|lung(4)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	14	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)					ATAACACTTTCAGATCTTTTG	0.373000													5	128					0	0	1	0	0
NBPF10	100132406	broad.mit.edu	37	1	145296403	145296403	+	Silent	SNP	C	C	T	rs4996269	by1000genomes	TCGA-XF-AAN4-01A-11D-A42E-08	TCGA-XF-AAN4-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ef58d603-784f-406e-b97d-ab2ce298601d	a06ce9e1-7c84-4520-aa93-bedc1d91a0f6	g.chr1:145296403C>T	ENST00000342960.5	+	3	360	c.325C>T	c.(325-327)Cta>Tta	p.L109L	NBPF10_ENST00000369338.1_Intron|NBPF10_ENST00000369339.3_Intron|RP11-458D21.5_ENST00000468030.1_3'UTR	NM_001039703.4	NP_001034792.4	A6NDV3	A6NDV3_HUMAN	neuroblastoma breakpoint family, member 10	109										NS(3)|breast(1)|central_nervous_system(3)|endometrium(12)|kidney(23)|lung(15)|ovary(1)|prostate(7)|skin(6)|urinary_tract(2)	73	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		GCTGACCCAGCTAAGGGAGAA	0.517000													5	316					0	0	1	0	0
FGFR4	2264	broad.mit.edu	37	5	176519668	176519668	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-AAN4-01A-11D-A42E-08	TCGA-XF-AAN4-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ef58d603-784f-406e-b97d-ab2ce298601d	a06ce9e1-7c84-4520-aa93-bedc1d91a0f6	g.chr5:176519668G>C	ENST00000292408.4	+	8	1185	c.940G>C	c.(940-942)Gag>Cag	p.E314Q	FGFR4_ENST00000292410.3_Missense_Mutation_p.E314Q|FGFR4_ENST00000393648.2_Missense_Mutation_p.E314Q|FGFR4_ENST00000502906.1_Missense_Mutation_p.E314Q|FGFR4_ENST00000393637.1_Missense_Mutation_p.E314Q	NM_002011.3|NM_213647.1	NP_002002.3|NP_998812.1	P22455	FGFR4_HUMAN	fibroblast growth factor receptor 4	314	Ig-like C2-type 3.				insulin receptor signaling pathway|positive regulation of cell proliferation	integral to plasma membrane	ATP binding|fibroblast growth factor binding|fibroblast growth factor receptor activity			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(16)|ovary(1)|prostate(2)|skin(2)|stomach(1)|urinary_tract(2)	34	all_cancers(89;5.93e-05)|Renal(175;0.000269)|Lung NSC(126;0.0088)|all_lung(126;0.0142)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)		Palifermin(DB00039)	CAATAGCTCAGAGGTGGAGGT	0.642000										TSP Lung(9;0.080)			3	28					0	0	1	0	0
TIMELESS	8914	broad.mit.edu	37	12	56818822	56818822	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-AAN4-01A-11D-A42E-08	TCGA-XF-AAN4-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ef58d603-784f-406e-b97d-ab2ce298601d	a06ce9e1-7c84-4520-aa93-bedc1d91a0f6	g.chr12:56818822C>G	ENST00000229201.4	-	14	1844	c.1690G>C	c.(1690-1692)Gag>Cag	p.E564Q	TIMELESS_ENST00000553532.1_Missense_Mutation_p.E565Q|TIMELESS_ENST00000554616.1_Intron	NM_003920.3	NP_003911.2	Q9UNS1	TIM_HUMAN	timeless circadian clock	565					cell division|circadian rhythm|detection of abiotic stimulus|mitosis|morphogenesis of an epithelium|negative regulation of transcription, DNA-dependent|regulation of S phase|response to DNA damage stimulus|transcription, DNA-dependent	nuclear chromatin				NS(1)|breast(2)|cervix(3)|endometrium(3)|kidney(3)|large_intestine(8)|lung(14)|ovary(7)|pancreas(2)|prostate(3)|skin(1)|stomach(1)|urinary_tract(1)	49						TGTAGCTGCTCAGCCAGGGCT	0.517000													7	96					0	0	1	0	0
DNAH7	56171	broad.mit.edu	37	2	196699053	196699053	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-AAN4-01A-11D-A42E-08	TCGA-XF-AAN4-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ef58d603-784f-406e-b97d-ab2ce298601d	a06ce9e1-7c84-4520-aa93-bedc1d91a0f6	g.chr2:196699053G>C	ENST00000312428.6	-	48	9077	c.8977C>G	c.(8977-8979)Cct>Gct	p.P2993A		NM_018897.2	NP_061720.2	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	2993	AAA 5 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(4)|breast(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(28)|liver(3)|lung(100)|ovary(4)|prostate(5)|skin(26)|upper_aerodigestive_tract(2)|urinary_tract(3)	205						TGACTTTGAGGATCTATCATC	0.393000													7	80					0	0	1	0	0
TCEAL5	340543	broad.mit.edu	37	X	102529118	102529118	+	Missense_Mutation	SNP	T	T	A			TCGA-XF-AAN4-01A-11D-A42E-08	TCGA-XF-AAN4-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ef58d603-784f-406e-b97d-ab2ce298601d	a06ce9e1-7c84-4520-aa93-bedc1d91a0f6	g.chrX:102529118T>A	ENST00000372680.1	-	3	668	c.374A>T	c.(373-375)gAc>gTc	p.D125V		NM_001012979.2	NP_001012997.1	Q5H9L2	TCAL5_HUMAN	transcription elongation factor A (SII)-like 5	125					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(5)|skin(1)	11						GGGGGAATCGTCCGTCCCCCT	0.572000													4	117					0	0	1	0	0
CXorf40A	91966	broad.mit.edu	37	X	148628334	148628334	+	Silent	SNP	C	C	G			TCGA-XF-AAN4-01A-11D-A42E-08	TCGA-XF-AAN4-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ef58d603-784f-406e-b97d-ab2ce298601d	a06ce9e1-7c84-4520-aa93-bedc1d91a0f6	g.chrX:148628334C>G	ENST00000441248.1	+	4	1890	c.303C>G	c.(301-303)ccC>ccG	p.P101P	CXorf40A_ENST00000428236.1_Silent_p.P39P|CXorf40A_ENST00000422892.2_Silent_p.P101P|CXorf40A_ENST00000423421.1_Silent_p.P101P|CXorf40A_ENST00000423540.2_Silent_p.P101P|CXorf40A_ENST00000514208.1_Silent_p.P101P|CXorf40A_ENST00000450602.2_Silent_p.P101P|CXorf40A_ENST00000359293.5_Silent_p.P101P|CXorf40A_ENST00000393985.3_Silent_p.P101P|CXorf40A_ENST00000434353.2_Silent_p.P101P			Q8TE69	CX04A_HUMAN	chromosome X open reading frame 40A	101							protein binding			breast(1)|endometrium(3)|large_intestine(1)|lung(2)	7	Acute lymphoblastic leukemia(192;6.56e-05)|Colorectal(9;0.0662)					ACTTAACTCCCGATGAGGTTG	0.468000													4	56					0	0	1	0	0
DNM1P47	100216544	broad.mit.edu	37	15	102299886	102299887	+	RNA	INS	-	-	G			TCGA-XF-AAN4-01A-11D-A42E-08	TCGA-XF-AAN4-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ef58d603-784f-406e-b97d-ab2ce298601d	a06ce9e1-7c84-4520-aa93-bedc1d91a0f6	g.chr15:102299886_102299887insG	ENST00000561463.1	+	0	7932_7933																											AACCTGTACTCGCGTCGGAACC	0.589													4	6	---	---	---	---					
RP13-329D4.3	0	broad.mit.edu	37	20	26113543	26113543	+	RNA	DEL	A	A	-			TCGA-XF-AAN4-01A-11D-A42E-08	TCGA-XF-AAN4-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ef58d603-784f-406e-b97d-ab2ce298601d	a06ce9e1-7c84-4520-aa93-bedc1d91a0f6	g.chr20:26113543delA	ENST00000416563.1	-	0	250																											TCTTTGCCTTAACAACATTAT	0.363													2	4	---	---	---	---