Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
CBFA2T3	863	broad.mit.edu	37	16	88958895	88958895	+	Splice_Site	SNP	T	T	G			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr16:88958895T>G	ENST00000268679.4	-	4	776		c.e4-2		CBFA2T3_ENST00000448839.1_Splice_Site|CBFA2T3_ENST00000360302.2_Splice_Site|CBFA2T3_ENST00000327483.5_Splice_Site|CBFA2T3_ENST00000436887.2_Splice_Site	NM_005187.5	NP_005178.4	O75081	MTG16_HUMAN	core-binding factor, runt domain, alpha subunit 2; translocated to, 3						cell proliferation|granulocyte differentiation	Golgi membrane|nucleolus|nucleoplasm	protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(3)|kidney(2)|large_intestine(4)|lung(5)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	17				BRCA - Breast invasive adenocarcinoma(80;0.0275)		CGTTCATCACTGCAGGAGGGA	0.587000			T	RUNX1	AML								19	43					0	0	1	0	0
SNRPD2	6633	broad.mit.edu	37	19	46191818	46191818	+	Silent	SNP	G	G	T			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr19:46191818G>T	ENST00000342669.3	-	2	453	c.9C>A	c.(7-9)ctC>ctA	p.L3L	SNRPD2_ENST00000587367.1_5'UTR|SNRPD2_ENST00000391932.3_5'UTR|SNRPD2_ENST00000588599.1_5'UTR|SNRPD2_ENST00000590212.1_Silent_p.L3L|SNRPD2_ENST00000585392.1_Intron|SNRPD2_ENST00000588301.1_Silent_p.L3L	NM_004597.5	NP_004588.1	P62316	SMD2_HUMAN	small nuclear ribonucleoprotein D2 polypeptide 16.5kDa	3					ncRNA metabolic process|spliceosomal snRNP assembly|spliceosome assembly	catalytic step 2 spliceosome|cytosol|nucleoplasm|small nuclear ribonucleoprotein complex|U12-type spliceosomal complex	protein binding			breast(1)|large_intestine(1)|lung(2)	4		Ovarian(192;0.051)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.00546)|GBM - Glioblastoma multiforme(486;0.0807)|Epithelial(262;0.194)		GCTTGTTGAGGAGGCTCCTGC	0.542000													34	51					3.76114e-14	4.14961e-14	1	1	0
PML	5371	broad.mit.edu	37	15	74336846	74336846	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr15:74336846G>A	ENST00000565898.1	+	8	2086	c.2002G>A	c.(2002-2004)Gag>Aag	p.E668K	PML_ENST00000268058.3_Missense_Mutation_p.E716K			P29590	PML_HUMAN	promyelocytic leukemia	716					cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction resulting in induction of apoptosis|endoplasmic reticulum calcium ion homeostasis|induction of apoptosis|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|maintenance of protein location in nucleus|negative regulation of angiogenesis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of mitotic cell cycle|negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|negative regulation of telomerase activity|negative regulation of telomere maintenance via telomerase|negative regulation of transcription, DNA-dependent|negative regulation of translation in response to oxidative stress|PML body organization|positive regulation of defense response to virus by host|positive regulation of histone deacetylation|protein complex assembly|protein stabilization|protein targeting|regulation of calcium ion transport into cytosol|regulation of protein phosphorylation|response to hypoxia|response to virus|transcription, DNA-dependent	cytoplasm|cytosol|early endosome membrane|extrinsic to endoplasmic reticulum membrane|insoluble fraction|nuclear matrix|nuclear membrane|nucleolus|nucleus|PML body	cobalt ion binding|DNA binding|protein binding|protein heterodimerization activity|protein homodimerization activity|SUMO binding|transcription coactivator activity|ubiquitin protein ligase binding|zinc ion binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(6)|lung(8)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	31						TCTCATCCGGGAGCGTGTGCC	0.637000			T	"""RARA, PAX5"""	"""APL, ALL"""								16	40					0	0	1	0	0
KEAP1	9817	broad.mit.edu	37	19	10602447	10602447	+	Silent	SNP	C	C	T			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr19:10602447C>T	ENST00000171111.5	-	3	1678	c.1131G>A	c.(1129-1131)gtG>gtA	p.V377V	KEAP1_ENST00000393623.2_Silent_p.V377V	NM_203500.1	NP_987096.1	Q14145	KEAP1_HUMAN	kelch-like ECH-associated protein 1	377					regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|midbody|nucleus	protein binding			breast(3)|endometrium(2)|kidney(4)|large_intestine(4)|liver(2)|lung(69)|ovary(2)|pancreas(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	92			OV - Ovarian serous cystadenocarcinoma(20;2.71e-09)|Epithelial(33;2.32e-06)|all cancers(31;1.42e-05)			TCCTGCCGCCCACGGCGTACA	0.692000													3	6					0	0	1	0	0
AGAP10	728127	broad.mit.edu	37	10	47207813	47207813	+	Splice_Site	SNP	T	T	C			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr10:47207813T>C	ENST00000355232.3	-	5	3482	c.470A>G	c.(469-471)cAt>cGt	p.H157R	AGAP10_ENST00000452145.2_Splice_Site_p.H132R|AGAP10_ENST00000413193.2_Splice_Site_p.H228R|RP11-144G6.12_ENST00000605970.1_RNA					ArfGAP with GTPase domain, ankyrin repeat and PH domain 10									p.H228R(20)		endometrium(5)|kidney(3)|lung(1)|prostate(2)|urinary_tract(1)	12						TTTACTTACATGGTTTGTACA	0.294000													4	82					0	0	1	0	0
ZNF492	57615	broad.mit.edu	37	19	22846919	22846919	+	Missense_Mutation	SNP	T	T	A			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr19:22846919T>A	ENST00000456783.2	+	4	692	c.448T>A	c.(448-450)Ttt>Att	p.F150I		NM_020855.2	NP_065906.1	Q9P255	ZN492_HUMAN	zinc finger protein 492	150					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|kidney(1)|large_intestine(6)|lung(10)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	21		all_cancers(12;0.0266)|all_lung(12;0.00187)|Lung NSC(12;0.0019)|all_epithelial(12;0.00203)|Hepatocellular(1079;0.244)				TGAAAAGTCATTTTGCATGCT	0.313000													9	14					0	0	1	0	0
MDN1	23195	broad.mit.edu	37	6	90406179	90406179	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr6:90406179G>A	ENST00000369393.3	-	60	9398	c.9283C>T	c.(9283-9285)Cac>Tac	p.H3095Y	MDN1_ENST00000428876.1_Missense_Mutation_p.H3095Y			Q9NU22	MDN1_HUMAN	MDN1, midasin homolog (yeast)	3095					protein complex assembly|regulation of protein complex assembly	nucleus	ATP binding|ATPase activity|unfolded protein binding			NS(1)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(22)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(52)|liver(1)|lung(83)|ovary(10)|pancreas(1)|prostate(10)|skin(6)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	218		all_cancers(76;1.47e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00246)		BRCA - Breast invasive adenocarcinoma(108;0.0193)		AGGGTCACGTGAGAGGAGGAA	0.498000													16	21					0	0	1	0	0
SLC10A5	347051	broad.mit.edu	37	8	82606749	82606749	+	Silent	SNP	C	C	T			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr8:82606749C>T	ENST00000518568.1	-	1	1660	c.459G>A	c.(457-459)ttG>ttA	p.L153L		NM_001010893.2	NP_001010893.1	Q5PT55	NTCP5_HUMAN	solute carrier family 10, member 5	153						integral to membrane	bile acid:sodium symporter activity			autonomic_ganglia(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(5)	15						CACACTTATTCAATAGTATTA	0.353000													22	55					0	0	1	0	0
TRAPPC3	27095	broad.mit.edu	37	1	36605707	36605707	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr1:36605707C>T	ENST00000373166.3	-	2	193	c.103G>A	c.(103-105)Gaa>Aaa	p.E35K	TRAPPC3_ENST00000373163.1_5'UTR|TRAPPC3_ENST00000373159.1_Missense_Mutation_p.E35K|TRAPPC3_ENST00000373162.1_5'UTR|TRAPPC3_ENST00000462715.1_5'UTR	NM_001270894.1|NM_014408.4	NP_001257823.1|NP_055223.1	O43617	TPPC3_HUMAN	trafficking protein particle complex 3	35						endoplasmic reticulum	guanylate cyclase activity|heme binding			central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(1)	4		Myeloproliferative disorder(586;0.0393)				TCATCATTTTCATAGTCCTTA	0.473000													6	18					0	0	1	0	0
TLX1	3195	broad.mit.edu	37	10	102896499	102896499	+	Silent	SNP	C	C	A			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr10:102896499C>A	ENST00000370196.6	+	3	2864	c.822C>A	c.(820-822)atC>atA	p.I274I	RP11-31L23.3_ENST00000411459.1_RNA|TLX1_ENST00000467928.2_3'UTR			P31314	TLX1_HUMAN	T-cell leukemia homeobox 1	274						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|upper_aerodigestive_tract(1)	2				Epithelial(162;6.35e-09)|all cancers(201;3.21e-07)		CGAACCGCATCCTCCTGCAGT	0.662000			T	"""TRB@, TRD@"""	T-ALL								30	54					3.73988e-18	4.22535e-18	1	1	0
PCDHA5	56143	broad.mit.edu	37	5	140201490	140201490	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr5:140201490G>A	ENST00000529859.1	+	1	130	c.130G>A	c.(130-132)Gtt>Att	p.V44I	PCDHA1_ENST00000394633.3_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA5_ENST00000529619.1_Missense_Mutation_p.V44I|PCDHA5_ENST00000378126.3_Missense_Mutation_p.V44I|PCDHA2_ENST00000526136.1_Intron	NM_018908.2	NP_061731.1												p.V44I(2)		NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(4)|kidney(6)|large_intestine(8)|liver(1)|lung(22)|ovary(2)|prostate(6)|skin(4)|upper_aerodigestive_tract(3)	60			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGGAACCTTCGTTGGCCGCAT	0.662000													5	78					0	0	1	0	0
NLRP8	126205	broad.mit.edu	37	19	56466330	56466330	+	Silent	SNP	G	G	A			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr19:56466330G>A	ENST00000291971.3	+	3	977	c.906G>A	c.(904-906)ctG>ctA	p.L302L	NLRP8_ENST00000590542.1_Silent_p.L302L	NM_176811.2	NP_789781.2	Q86W28	NALP8_HUMAN	NLR family, pyrin domain containing 8	302	NACHT.					cytoplasm	ATP binding			breast(4)|central_nervous_system(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(14)|ovary(5)|skin(2)|stomach(3)|upper_aerodigestive_tract(2)	35		Colorectal(82;0.000147)|Ovarian(87;0.17)		GBM - Glioblastoma multiforme(193;0.0695)		TGGAGGACCTGAGTGAAGACT	0.498000													33	84					0	0	1	0	0
IFT46	56912	broad.mit.edu	37	11	118425976	118425976	+	Nonsense_Mutation	SNP	G	G	A			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr11:118425976G>A	ENST00000264020.2	-	6	777	c.400C>T	c.(400-402)Cag>Tag	p.Q134*	IFT46_ENST00000530872.1_Nonsense_Mutation_p.Q134*|IFT46_ENST00000264021.3_Nonsense_Mutation_p.Q83*	NM_020153.3	NP_064538.3	Q9NQC8	IFT46_HUMAN	intraflagellar transport 46 homolog (Chlamydomonas)	83					flagellum assembly|intraflagellar transport|protein stabilization	microtubule basal body|microtubule-based flagellum|nucleus	protein C-terminus binding			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(4)	9						CTGATGTACTGGAAGAGTTCC	0.493000													5	65					0	0	1	0	0
MYH9	4627	broad.mit.edu	37	22	36684882	36684882	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr22:36684882G>A	ENST00000216181.5	-	33	4891	c.4661C>T	c.(4660-4662)gCc>gTc	p.A1554V		NM_002473.4	NP_002464.1	P35579	MYH9_HUMAN	myosin, heavy chain 9, non-muscle	1554					actin cytoskeleton reorganization|actin filament-based movement|angiogenesis|axon guidance|blood vessel endothelial cell migration|cytokinesis|integrin-mediated signaling pathway|leukocyte migration|membrane protein ectodomain proteolysis|monocyte differentiation|platelet formation|protein transport|regulation of cell shape	actomyosin contractile ring|cleavage furrow|cytosol|myosin complex|nucleus|ruffle|stress fiber|uropod	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity|protein anchor|protein homodimerization activity			NS(1)|breast(8)|central_nervous_system(3)|cervix(2)|endometrium(5)|kidney(4)|large_intestine(16)|lung(29)|ovary(4)|pancreas(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(6)|urinary_tract(3)	86						CCGCAGCTTGGCATCTTCGGT	0.632000			T	ALK	ALCL		"""Deafness, autosomal dominant 17, Epstein syndrome, Fechtner syndrome, May-Hegglin anomaly, Sebastian syndrome"""		Hereditary Macrothrombocytopenia, MYH9-associated				9	138					0	0	1	0	0
UNC93B1	81622	broad.mit.edu	37	11	67759316	67759316	+	Missense_Mutation	SNP	C	C	T	rs4014596		TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr11:67759316C>T	ENST00000227471.2	-	12	1571	c.1492G>A	c.(1492-1494)Gtg>Atg	p.V498M	UNC93B1_ENST00000530331.1_5'UTR	NM_030930.2	NP_112192.2	Q9H1C4	UN93B_HUMAN	unc-93 homolog B1 (C. elegans)	499					innate immune response|intracellular protein transport|response to virus|toll-like receptor 3 signaling pathway|toll-like receptor 7 signaling pathway|toll-like receptor 9 signaling pathway	early phagosome|endoplasmic reticulum membrane|endosome|integral to membrane|lysosome		p.V498M(1)									ACCAGCAGCACCGCCAGCTTA	0.741000													3	8					0	0	1	0	0
RTDR1	27156	broad.mit.edu	37	22	23406223	23406223	+	Silent	SNP	G	G	A			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr22:23406223G>A	ENST00000216036.4	-	5	706	c.510C>T	c.(508-510)ttC>ttT	p.F170F		NM_014433.2	NP_055248.1	Q9UHP6	RTDR1_HUMAN	rhabdoid tumor deletion region gene 1	170							binding			breast(1)|endometrium(3)|large_intestine(4)|lung(6)|ovary(1)|prostate(1)|stomach(1)|urinary_tract(1)	18	all_hematologic(9;0.0197)|Acute lymphoblastic leukemia(84;0.181)			READ - Rectum adenocarcinoma(21;0.175)		TGTCCAGGATGAACTCCTGGA	0.587000													10	34					0	0	1	0	0
TREH	11181	broad.mit.edu	37	11	118531384	118531384	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr11:118531384G>C	ENST00000529101.1	-	10	1011	c.966C>G	c.(964-966)ttC>ttG	p.F322L	TREH_ENST00000525958.1_Missense_Mutation_p.F291L|TREH_ENST00000264029.4_Missense_Mutation_p.F322L|TREH_ENST00000530256.1_Missense_Mutation_p.F199L|TREH_ENST00000397925.1_Missense_Mutation_p.F291L			O43280	TREA_HUMAN	trehalase (brush-border membrane glycoprotein)	322					polysaccharide digestion|trehalose catabolic process	anchored to plasma membrane	alpha,alpha-trehalase activity			NS(1)|endometrium(1)|kidney(3)|large_intestine(2)|lung(3)|ovary(1)|pancreas(1)|urinary_tract(1)	13	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0425)|all_hematologic(192;0.0564)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;3.16e-05)		AGCGTGAAGAGAAGTCCCAGC	0.607000													7	5					0	0	1	0	0
LIN9	286826	broad.mit.edu	37	1	226421213	226421213	+	Silent	SNP	G	G	A			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr1:226421213G>A	ENST00000328205.5	-	13	1850	c.1305C>T	c.(1303-1305)gaC>gaT	p.D435D	LIN9_ENST00000481685.1_Silent_p.D400D|LIN9_ENST00000366801.1_Silent_p.D384D	NM_173083.3	NP_775106.2	Q5TKA1	LIN9_HUMAN	lin-9 homolog (C. elegans)	419					cell cycle|DNA replication	nucleoplasm				breast(3)|endometrium(4)|kidney(2)|large_intestine(6)|lung(9)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	28	Breast(184;0.158)			GBM - Glioblastoma multiforme(131;0.131)		GGAGCCCCTGGTCTGGAGCAA	0.463000													28	49					0	0	1	0	0
PRKDC	5591	broad.mit.edu	37	8	48746857	48746857	+	Silent	SNP	C	C	T			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr8:48746857C>T	ENST00000314191.2	-	60	8105	c.8049G>A	c.(8047-8049)agG>agA	p.R2683R	PRKDC_ENST00000338368.3_Silent_p.R2683R|PRKDC_ENST00000523565.1_5'UTR	NM_006904.6	NP_008835.5	P78527	PRKDC_HUMAN	protein kinase, DNA-activated, catalytic polypeptide	2684	KIP-binding.				cellular response to insulin stimulus|double-strand break repair via nonhomologous end joining|peptidyl-serine phosphorylation|positive regulation of transcription from RNA polymerase II promoter	DNA-dependent protein kinase-DNA ligase 4 complex|transcription factor complex	ATP binding|DNA binding|DNA-dependent protein kinase activity|transcription factor binding			NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(9)|cervix(3)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(30)|lung(56)|ovary(6)|pancreas(1)|prostate(8)|skin(7)	147		all_cancers(86;0.0336)|all_epithelial(80;0.00111)|Lung NSC(129;0.00363)|all_lung(136;0.00391)				ACCTTTCACTCCTCTTGTGGG	0.532000								Non-homologous end-joining					68	153					0	0	1	0	0
CSMD3	114788	broad.mit.edu	37	8	113518990	113518990	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr8:113518990G>C	ENST00000297405.5	-	29	5069	c.4825C>G	c.(4825-4827)Ccg>Gcg	p.P1609A	CSMD3_ENST00000455883.2_Missense_Mutation_p.P1505A|CSMD3_ENST00000352409.3_Missense_Mutation_p.P1609A|CSMD3_ENST00000343508.3_Missense_Mutation_p.P1569A	NM_198123.1	NP_937756.1	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3	1609	CUB 9.					integral to membrane|plasma membrane				breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						CTGCTATGCGGATATGGATGA	0.383000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			30	46					0	0	1	0	0
FUCA2	2519	broad.mit.edu	37	6	143825328	143825328	+	Silent	SNP	C	C	T			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr6:143825328C>T	ENST00000002165.6	-	3	529	c.474G>A	c.(472-474)aaG>aaA	p.K158K	RP1-20N2.6_ENST00000593175.1_RNA|RP1-20N2.6_ENST00000591189.1_RNA|FUCA2_ENST00000438118.2_Intron|RP1-20N2.6_ENST00000415586.1_RNA|RP1-20N2.6_ENST00000593045.1_RNA|FUCA2_ENST00000367585.1_Intron|RP1-20N2.6_ENST00000590703.1_RNA|RP1-20N2.6_ENST00000591892.1_RNA|RP1-20N2.6_ENST00000589563.1_RNA	NM_032020.4	NP_114409.2	Q9BTY2	FUCO2_HUMAN	fucosidase, alpha-L- 2, plasma						fucose metabolic process	extracellular region	alpha-L-fucosidase activity|cation binding			endometrium(1)|large_intestine(1)|lung(2)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	9				OV - Ovarian serous cystadenocarcinoma(155;7.45e-06)|GBM - Glioblastoma multiforme(68;0.0142)		CAATGTCCCTCTTGGGCCCCT	0.448000													25	69					0	0	1	0	0
GABRR2	2570	broad.mit.edu	37	6	89975445	89975445	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr6:89975445C>T	ENST00000402938.3	-	7	909	c.776G>A	c.(775-777)cGc>cAc	p.R259H	GABRR2_ENST00000602399.1_Missense_Mutation_p.R284H	NM_002043.3	NP_002034.3	P28476	GBRR2_HUMAN	gamma-aminobutyric acid (GABA) A receptor, rho 2	284					synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			central_nervous_system(1)|endometrium(2)|large_intestine(5)|lung(10)|prostate(2)|urinary_tract(1)	21		all_cancers(76;1.67e-09)|Prostate(29;1.16e-10)|Acute lymphoblastic leukemia(125;1.49e-10)|all_hematologic(105;7.77e-07)|all_epithelial(107;2.51e-05)|Lung NSC(302;0.238)		BRCA - Breast invasive adenocarcinoma(108;0.0158)		GAAGATGTGGCGACGCAACGT	0.522000													12	42					0	0	1	0	0
PPP4R1	9989	broad.mit.edu	37	18	9553421	9553421	+	Splice_Site	SNP	C	C	G			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr18:9553421C>G	ENST00000400556.3	-	16	2264		c.e16-1		PPP4R1_ENST00000400555.3_Splice_Site	NM_001042388.2	NP_001035847.1	Q8TF05	PP4R1_HUMAN	protein phosphatase 4, regulatory subunit 1						protein phosphorylation|signal transduction	protein phosphatase 4 complex	protein binding|protein phosphatase type 4 regulator activity			large_intestine(1)|skin(2)	3						TATGAAGAAGCTAAAGTAACA	0.328000													11	18					0	0	1	0	0
HPS6	79803	broad.mit.edu	37	10	103826346	103826346	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr10:103826346G>A	ENST00000299238.5	+	1	1200	c.1115G>A	c.(1114-1116)cGa>cAa	p.R372Q		NM_024747.5	NP_079023.2	Q86YV9	HPS6_HUMAN	Hermansky-Pudlak syndrome 6	372						cytosol|early endosome membrane|endoplasmic reticulum|microsome				endometrium(1)|kidney(1)|large_intestine(4)|lung(4)|prostate(1)	11		Colorectal(252;0.122)		Epithelial(162;5.93e-08)|all cancers(201;1.03e-06)		CTGGAGACCCGAGGGAATCTT	0.572000									Hermansky-Pudlak syndrome				27	30					0	0	1	0	0
CCNL1	57018	broad.mit.edu	37	3	156877690	156877690	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr3:156877690G>C	ENST00000295926.3	-	1	312	c.194C>G	c.(193-195)tCg>tGg	p.S65W	CCNL1_ENST00000461804.1_Missense_Mutation_p.S65W|CCNL1_ENST00000295925.4_Missense_Mutation_p.S65W	NM_020307.2	NP_064703.1	Q9UK58	CCNL1_HUMAN	cyclin L1	65					regulation of cyclin-dependent protein kinase activity|regulation of transcription, DNA-dependent|RNA processing|transcription, DNA-dependent	nuclear speck	protein kinase binding			NS(1)|breast(1)|cervix(2)|kidney(1)|large_intestine(3)|lung(8)|skin(1)|stomach(1)	18			LUSC - Lung squamous cell carcinoma(72;0.0295)|Lung(72;0.0308)			TGGGGTGGGCGAGAGCCTCTC	0.627000													4	5					0	0	1	0	0
MUC2	4583	broad.mit.edu	37	11	1097850	1097850	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr11:1097850G>A	ENST00000441003.2	+	36	6970	c.6943G>A	c.(6943-6945)Ggg>Agg	p.G2315R	MUC2_ENST00000361558.6_3'UTR	NM_002457.2	NP_002448.2	Q02817	MUC2_HUMAN	mucin 2, oligomeric mucus/gel-forming	4677						inner mucus layer|outer mucus layer	protein binding			NS(3)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(26)|haematopoietic_and_lymphoid_tissue(4)|kidney(11)|large_intestine(5)|lung(22)|ovary(2)|prostate(16)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	102		all_cancers(49;1.08e-07)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.191)		BRCA - Breast invasive adenocarcinoma(625;0.000207)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)	Pranlukast(DB01411)	CACTGTGCCCGGGGGCGGTAA	0.677000													4	16					0	0	1	0	0
PIGZ	80235	broad.mit.edu	37	3	196674848	196674848	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr3:196674848G>A	ENST00000412723.1	-	3	1066	c.920C>T	c.(919-921)gCg>gTg	p.A307V		NM_025163.2	NP_079439.2	Q86VD9	PIGZ_HUMAN	phosphatidylinositol glycan anchor biosynthesis, class Z	307					GPI anchor biosynthetic process	integral to membrane|intrinsic to endoplasmic reticulum membrane	alpha-1,2-mannosyltransferase activity			breast(1)|endometrium(1)|lung(7)|ovary(3)|prostate(1)|urinary_tract(1)	14	all_cancers(143;1.05e-08)|Ovarian(172;0.0634)|Breast(254;0.0838)		Epithelial(36;4.29e-24)|all cancers(36;2.79e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.03e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00603)		GCCATGTCTCGCCAGGTTTTG	0.612000													50	75					0	0	1	0	0
FAM21EP	100421577	broad.mit.edu	37	10	51818909	51818909	+	RNA	SNP	C	C	T			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr10:51818909C>T	ENST00000456967.1	-	0	1521					NR_038275.1																						tcgtcatcatcatcaccatca	0.512000													16	18					0	0	1	0	0
SPTBN5	51332	broad.mit.edu	37	15	42171994	42171994	+	Silent	SNP	C	C	G			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr15:42171994C>G	ENST00000320955.6	-	15	3107	c.2880G>C	c.(2878-2880)ctG>ctC	p.L960L		NM_016642.2	NP_057726.4	Q9NRC6	SPTN5_HUMAN	spectrin, beta, non-erythrocytic 5	960					actin cytoskeleton organization|actin filament capping|axon guidance	cytosol|membrane|spectrin				NS(1)|breast(1)|central_nervous_system(3)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(6)|lung(18)|ovary(5)|prostate(8)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	62		all_cancers(109;1.84e-17)|all_epithelial(112;1.12e-15)|Lung NSC(122;7.6e-10)|all_lung(180;4.15e-09)|Melanoma(134;0.0179)|Ovarian(310;0.143)|Colorectal(260;0.173)		all cancers(2;4.33e-34)|Epithelial(2;1.72e-25)|OV - Ovarian serous cystadenocarcinoma(18;8.32e-20)|GBM - Glioblastoma multiforme(94;4.69e-07)|Colorectal(2;0.00104)|COAD - Colon adenocarcinoma(120;0.0405)|READ - Rectum adenocarcinoma(92;0.0908)		ATCTCTGCCTCAGTTGCTCAG	0.587000													20	59					0	0	1	0	0
PRKD1	5587	broad.mit.edu	37	14	30047542	30047542	+	Missense_Mutation	SNP	A	A	G			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr14:30047542A>G	ENST00000331968.5	-	17	2688	c.2459T>C	c.(2458-2460)cTg>cCg	p.L820P	PRKD1_ENST00000415220.2_Missense_Mutation_p.L828P	NM_002742.2	NP_002733.2	Q15139	KPCD1_HUMAN	protein kinase D1	820	Protein kinase.				cell proliferation|intracellular signal transduction|sphingolipid metabolic process	cytosol|integral to plasma membrane	ATP binding|metal ion binding|protein binding|protein kinase C activity			NS(1)|breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(21)|lung(32)|ovary(2)|prostate(1)|skin(4)|urinary_tract(2)	78	Hepatocellular(127;0.0604)		LUAD - Lung adenocarcinoma(48;0.00527)|Lung(238;0.0252)	GBM - Glioblastoma multiforme(265;0.00888)		TTTTACTTGCAGCAAATTGTT	0.333000													16	33					0	0	1	0	0
ZNF404	342908	broad.mit.edu	37	19	44384189	44384189	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr19:44384189C>G	ENST00000587539.1	-	2	108	c.109G>C	c.(109-111)Gag>Cag	p.E37Q	ZNF404_ENST00000324394.6_Missense_Mutation_p.E35Q	NM_001033719.2	NP_001028891.2	Q494X3	ZN404_HUMAN	zinc finger protein 404	37	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(3)|skin(1)|stomach(2)|urinary_tract(1)	17		Prostate(69;0.0352)				GTATAATTCTCCAACATCACA	0.388000													52	70					0	0	1	0	0
FZD2	2535	broad.mit.edu	37	17	42636592	42636592	+	Silent	SNP	G	G	A			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr17:42636592G>A	ENST00000315323.3	+	1	1668	c.1536G>A	c.(1534-1536)ccG>ccA	p.P512P		NM_001466.3	NP_001457.1	Q14332	FZD2_HUMAN	frizzled family receptor 2	512					axonogenesis|brain development|canonical Wnt receptor signaling pathway|epithelial cell differentiation|G-protein signaling, coupled to cGMP nucleotide second messenger|gonad development|positive regulation of cGMP metabolic process|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|vasculature development|Wnt receptor signaling pathway, calcium modulating pathway	apical part of cell|cytoplasm|integral to membrane|neuron projection membrane	G-protein coupled receptor activity|PDZ domain binding|Wnt receptor activity|Wnt-protein binding			central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(7)|lung(9)|ovary(3)|prostate(8)	33		Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.189)		ACTACACGCCGCGCATGTCGC	0.632000													11	34					0	0	1	0	0
LDHAL6A	160287	broad.mit.edu	37	11	18497978	18497978	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr11:18497978C>A	ENST00000280706.2	+	5	1437	c.640C>A	c.(640-642)Ctg>Atg	p.L214M	TSG101_ENST00000536719.1_Intron|LDHAL6A_ENST00000396213.3_Missense_Mutation_p.L214M	NM_144972.4	NP_659409.2	Q6ZMR3	LDH6A_HUMAN	lactate dehydrogenase A-like 6A	214					glycolysis	cytoplasm	binding|L-lactate dehydrogenase activity			large_intestine(3)|lung(9)|urinary_tract(1)	13					NADH(DB00157)	TCTGAAGGATCTGAACCCAGA	0.423000													35	37					4.65686e-17	5.23619e-17	1	1	0
NWD1	284434	broad.mit.edu	37	19	16872917	16872917	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr19:16872917C>G	ENST00000524140.2	+	8	2519	c.2101C>G	c.(2101-2103)Ctt>Gtt	p.L701V	NWD1_ENST00000379808.3_Missense_Mutation_p.L701V|NWD1_ENST00000549814.1_Missense_Mutation_p.L701V|NWD1_ENST00000523826.1_Missense_Mutation_p.L495V|NWD1_ENST00000339803.6_Missense_Mutation_p.L566V|NWD1_ENST00000552788.1_Missense_Mutation_p.L701V	NM_001007525.3	NP_001007526.3	Q149M9	NWD1_HUMAN	NACHT and WD repeat domain containing 1	701							ATP binding			NS(3)|breast(2)|cervix(1)|endometrium(8)|large_intestine(17)|lung(18)|ovary(2)|pancreas(3)|prostate(5)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	67						CACTCTGCCACTTGTGGGGAA	0.592000													8	18					0	0	1	0	0
SRGAP2	23380	broad.mit.edu	37	1	206566199	206566199	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr1:206566199C>T	ENST00000414007.1	+	2	220	c.220C>T	c.(220-222)Cgc>Tgc	p.R74C	SRGAP2_ENST00000419187.2_5'UTR			O75044	FNBP2_HUMAN	SLIT-ROBO Rho GTPase activating protein 2	214	FCH.				axon guidance|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|protein binding	p.R74C(1)		NS(1)|breast(1)|kidney(1)|lung(1)	4	Breast(84;0.137)					GGCCAACGTTCGCATTGAGGA	0.532000													4	29					0	0	1	0	0
SPSB3	90864	broad.mit.edu	37	16	1827778	1827778	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr16:1827778G>T	ENST00000566339.1	-	6	1021	c.691C>A	c.(691-693)Ctc>Atc	p.L231I	SPSB3_ENST00000301717.4_Missense_Mutation_p.L231I	NM_080861.3	NP_543137.2	Q6PJ21	SPSB3_HUMAN	splA/ryanodine receptor domain and SOCS box containing 3	231	B30.2/SPRY.				intracellular signal transduction					endometrium(1)|kidney(4)|lung(3)|prostate(2)	10						AAAAAGGTGAGTGTGCCGTGC	0.627000													14	35					1.49906e-05	1.57973e-05	1	1	0
CLCN6	1185	broad.mit.edu	37	1	11883766	11883766	+	Silent	SNP	G	G	A			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr1:11883766G>A	ENST00000346436.6	+	7	508	c.456G>A	c.(454-456)ccG>ccA	p.P152P	CLCN6_ENST00000312413.6_Silent_p.P152P|CLCN6_ENST00000376492.3_3'UTR|CLCN6_ENST00000376496.3_Silent_p.P152P|CLCN6_ENST00000376487.3_Silent_p.P130P	NM_001286.3	NP_001277	P51797	CLCN6_HUMAN	chloride channel, voltage-sensitive 6	152					cell volume homeostasis|signal transduction	endosome membrane|integral to membrane	antiporter activity|ATP binding|voltage-gated chloride channel activity			cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(7)|lung(12)|prostate(2)|skin(4)	36	Ovarian(185;0.249)	Lung NSC(185;8.69e-05)|all_lung(284;9.87e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.13e-06)|COAD - Colon adenocarcinoma(227;0.000274)|BRCA - Breast invasive adenocarcinoma(304;0.000311)|Kidney(185;0.000816)|KIRC - Kidney renal clear cell carcinoma(229;0.00268)|STAD - Stomach adenocarcinoma(313;0.00743)|READ - Rectum adenocarcinoma(331;0.0649)		TCCATCAGCCGGTGGCAGCAG	0.582000													16	40					0	0	1	0	0
RLTPR	146206	broad.mit.edu	37	16	67686219	67686219	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr16:67686219G>A	ENST00000334583.6	+	27	3122	c.2794G>A	c.(2794-2796)Gag>Aag	p.E932K	RLTPR_ENST00000545661.1_Missense_Mutation_p.E896K	NM_001013838.1	NP_001013860.1	Q6F5E8	LR16C_HUMAN	RGD motif, leucine rich repeats, tropomodulin domain and proline-rich containing	932	Pro-rich.									breast(1)|cervix(1)|endometrium(4)|kidney(1)|lung(9)|urinary_tract(2)	18		Acute lymphoblastic leukemia(13;3.23e-05)|all_hematologic(13;0.00251)|Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0146)|Epithelial(162;0.0481)|all cancers(182;0.232)		CTTCCCCGaggagaaggaaga	0.567000													14	26					0	0	1	0	0
PUS7	54517	broad.mit.edu	37	7	105112641	105112641	+	Splice_Site	SNP	C	C	T			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr7:105112641C>T	ENST00000356362.2	-	10	1390		c.e10-1		PUS7_ENST00000469408.1_Splice_Site	NM_019042.3	NP_061915.2	Q96PZ0	PUS7_HUMAN	pseudouridylate synthase 7 homolog (S. cerevisiae)						pseudouridine synthesis|tRNA processing		pseudouridine synthase activity|RNA binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(9)|lung(8)|pancreas(1)|skin(1)	23						TAGTATAGCTCTAAAATTAAA	0.279000													28	61					0	0	1	0	0
HPS6	79803	broad.mit.edu	37	10	103827338	103827338	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr10:103827338G>A	ENST00000299238.5	+	1	2192	c.2107G>A	c.(2107-2109)Gag>Aag	p.E703K		NM_024747.5	NP_079023.2	Q86YV9	HPS6_HUMAN	Hermansky-Pudlak syndrome 6	703						cytosol|early endosome membrane|endoplasmic reticulum|microsome				endometrium(1)|kidney(1)|large_intestine(4)|lung(4)|prostate(1)	11		Colorectal(252;0.122)		Epithelial(162;5.93e-08)|all cancers(201;1.03e-06)		GGCTCCAGCTGAGCTCCTGCT	0.622000									Hermansky-Pudlak syndrome				22	45					0	0	1	0	0
VPS13B	157680	broad.mit.edu	37	8	100654439	100654439	+	Missense_Mutation	SNP	A	A	G			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr8:100654439A>G	ENST00000358544.2	+	34	5807	c.5696A>G	c.(5695-5697)gAt>gGt	p.D1899G	VPS13B_ENST00000357162.2_Missense_Mutation_p.D1874G|VPS13B_ENST00000395996.1_3'UTR	NM_017890.4	NP_060360.3	Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13 homolog B (yeast)	1899					protein transport					NS(1)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(37)|lung(78)|ovary(8)|pancreas(3)|prostate(5)|skin(9)|upper_aerodigestive_tract(4)|urinary_tract(9)	193	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			ACAGCAGAAGATCTCTTAAGG	0.413000													6	136					0	0	1	0	0
TFRC	7037	broad.mit.edu	37	3	195794522	195794522	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr3:195794522G>T	ENST00000360110.4	-	9	1076	c.907C>A	c.(907-909)Ctg>Atg	p.L303M	TFRC_ENST00000420415.1_Missense_Mutation_p.L222M|TFRC_ENST00000392396.3_Missense_Mutation_p.L303M|TFRC_ENST00000540528.1_3'UTR|TFRC_ENST00000535031.1_Missense_Mutation_p.L21M	NM_001128148.1	NP_001121620.1	P02786	TFR1_HUMAN	transferrin receptor	303	PA.				cellular iron ion homeostasis|endocytosis|interspecies interaction between organisms|proteolysis|transferrin transport|transmembrane transport	coated pit|endosome|integral to plasma membrane|melanosome	peptidase activity|transferrin receptor activity			NS(1)|breast(2)|endometrium(1)|kidney(3)|large_intestine(4)|lung(10)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	27	all_cancers(143;1.94e-08)|Ovarian(172;0.0634)|Breast(254;0.206)		Epithelial(36;1.36e-24)|all cancers(36;3.34e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.17e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00233)		CCTGTCCCCAGATGAGCCTAG	0.458000			T	BCL6	NHL								17	26					5.3912e-06	5.73273e-06	1	1	0
REXO1	57455	broad.mit.edu	37	19	1817250	1817250	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr19:1817250G>A	ENST00000170168.4	-	12	3263	c.3169C>T	c.(3169-3171)Cac>Tac	p.H1057Y		NM_020695.3	NP_065746.3	Q8N1G1	REXO1_HUMAN	REX1, RNA exonuclease 1 homolog (S. cerevisiae)	1057						nucleus	exonuclease activity|nucleic acid binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(5)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	16		Ovarian(11;1.78e-06)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		ATCCCCGGGTGGGTGTCTCCT	0.642000													20	25					0	0	1	0	0
COL6A6	131873	broad.mit.edu	37	3	130380682	130380682	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr3:130380682C>T	ENST00000358511.6	+	34	6063	c.6032C>T	c.(6031-6033)gCc>gTc	p.A2011V	COL6A6_ENST00000453409.2_Missense_Mutation_p.A2011V	NM_001102608.1	NP_001096078.1	A6NMZ7	CO6A6_HUMAN	collagen, type VI, alpha 6	2011	Nonhelical region.|VWFA 9.				axon guidance|cell adhesion	collagen				NS(2)|breast(5)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(30)|lung(57)|ovary(8)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	134						GACCGGGTGGCCCTATTGAGC	0.502000													16	20					0	0	1	0	0
PLEC	5339	broad.mit.edu	37	8	144999878	144999878	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr8:144999878C>T	ENST00000322810.4	-	31	4799	c.4630G>A	c.(4630-4632)Gcg>Acg	p.A1544T	PLEC_ENST00000357649.2_Missense_Mutation_p.A1411T|PLEC_ENST00000436759.2_Missense_Mutation_p.A1434T|PLEC_ENST00000398774.2_Missense_Mutation_p.A1375T|PLEC_ENST00000527096.1_Missense_Mutation_p.A1430T|PLEC_ENST00000354958.2_Missense_Mutation_p.A1385T|PLEC_ENST00000356346.3_Missense_Mutation_p.A1393T|PLEC_ENST00000354589.3_Missense_Mutation_p.A1407T|PLEC_ENST00000345136.3_Missense_Mutation_p.A1407T	NM_201380.2	NP_958782.1	Q15149	PLEC_HUMAN	plectin	1544	Central fibrous rod domain.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle			NS(1)|breast(3)|central_nervous_system(4)|cervix(7)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(8)|lung(57)|ovary(4)|pancreas(2)|prostate(11)|skin(9)|stomach(2)|upper_aerodigestive_tract(10)	137						TCCACCGCCGCCTCCTCCCGC	0.721000													9	15					0	0	1	0	0
PCNXL3	399909	broad.mit.edu	37	11	65385688	65385688	+	Silent	SNP	G	G	A			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr11:65385688G>A	ENST00000355703.3	+	6	1394	c.855G>A	c.(853-855)cgG>cgA	p.R285R		NM_032223.2	NP_115599.2	Q9H6A9	PCX3_HUMAN	pecanex-like 3 (Drosophila)	285						integral to membrane				breast(1)|endometrium(2)|kidney(2)|large_intestine(1)|lung(6)|prostate(1)	13						TTGACCGGCGGGGCTCAGGGG	0.652000													4	41					0	0	1	0	0
CRISPLD2	83716	broad.mit.edu	37	16	84879412	84879412	+	Silent	SNP	G	G	A			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr16:84879412G>A	ENST00000262424.5	+	3	485	c.261G>A	c.(259-261)gaG>gaA	p.E87E	CRISPLD2_ENST00000567845.1_Silent_p.E87E|CRISPLD2_ENST00000564567.1_Silent_p.E87E|CRISPLD2_ENST00000566431.1_3'UTR|CRISPLD2_ENST00000569090.1_Silent_p.E87E	NM_031476.3	NP_113664.1	Q9H0B8	CRLD2_HUMAN	cysteine-rich secretory protein LCCL domain containing 2	87						extracellular region|transport vesicle				endometrium(3)|large_intestine(5)|lung(8)|prostate(1)|stomach(1)	18						ACGAACTGGAGAAGTCTGCTG	0.617000													19	40					0	0	1	0	0
RGPD3	653489	broad.mit.edu	37	2	107049631	107049631	+	Silent	SNP	C	C	T			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr2:107049631C>T	ENST00000409886.3	-	16	2403	c.2316G>A	c.(2314-2316)gcG>gcA	p.A772A	RGPD3_ENST00000304514.7_Silent_p.A772A	NM_001144013.1	NP_001137485.1	A6NKT7	RGPD3_HUMAN	RANBP2-like and GRIP domain containing 3	772					intracellular transport		binding	p.A772A(4)		breast(2)|central_nervous_system(1)|endometrium(50)|kidney(4)|lung(11)|ovary(1)|urinary_tract(2)	71						TTTCTGAATCCGCATTTCGCA	0.373000													5	305					0	0	1	0	0
HIPK2	28996	broad.mit.edu	37	7	139299093	139299093	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr7:139299093C>G	ENST00000406875.3	-	8	2023	c.1929G>C	c.(1927-1929)caG>caC	p.Q643H	HIPK2_ENST00000342645.6_Missense_Mutation_p.Q643H|HIPK2_ENST00000428878.2_Missense_Mutation_p.Q616H	NM_022740.4	NP_073577.3	Q9H2X6	HIPK2_HUMAN	homeodomain interacting protein kinase 2	643	Interaction with SKI and SMAD1.				apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|negative regulation of BMP signaling pathway|positive regulation of JNK cascade|positive regulation of transforming growth factor beta receptor signaling pathway|SMAD protein signal transduction|transcription, DNA-dependent|virus-host interaction	centrosome|nuclear membrane|PML body	ATP binding|protein serine/threonine kinase activity|SMAD binding|transcription corepressor activity|virion binding			breast(4)|central_nervous_system(4)|endometrium(7)|kidney(2)|large_intestine(5)|lung(11)|ovary(3)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	43	Melanoma(164;0.205)					GGGCACAAATCTGGGCTGTTC	0.587000													14	34					0	0	1	0	0
CDKN2A	1029	broad.mit.edu	37	9	21971208	21971208	+	Splice_Site	SNP	C	C	G			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr9:21971208C>G	ENST00000579755.1	-	2	486		c.e2-1		CDKN2A_ENST00000361570.3_Splice_Site|CDKN2A_ENST00000497750.1_Splice_Site|CDKN2A_ENST00000494262.1_Splice_Site|CDKN2A_ENST00000479692.2_Splice_Site|CDKN2A_ENST00000578845.2_5'UTR|CDKN2A_ENST00000498628.2_Splice_Site|CDKN2A_ENST00000498124.1_Splice_Site|CDKN2A_ENST00000530628.2_Splice_Site|CDKN2A_ENST00000579122.1_Splice_Site|CDKN2A_ENST00000304494.5_Splice_Site|RP11-145E5.5_ENST00000404796.2_Intron|CDKN2A_ENST00000446177.1_Splice_Site			P42771	CD2A1_HUMAN	cyclin-dependent kinase inhibitor 2A						cell cycle arrest|cell cycle checkpoint|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of cell-matrix adhesion|negative regulation of cyclin-dependent protein kinase activity|negative regulation of NF-kappaB transcription factor activity|positive regulation of macrophage apoptosis|positive regulation of smooth muscle cell apoptosis|Ras protein signal transduction|replicative senescence	cytosol|nucleus	cyclin-dependent protein kinase inhibitor activity|NF-kappaB binding|protein binding|protein kinase binding	p.0?(1315)|p.?(38)|p.0(1)|p.V28_V51del(1)		NS(28)|adrenal_gland(6)|autonomic_ganglia(11)|biliary_tract(74)|bone(84)|breast(46)|central_nervous_system(522)|cervix(23)|endometrium(14)|eye(4)|genital_tract(15)|haematopoietic_and_lymphoid_tissue(698)|kidney(39)|large_intestine(11)|liver(92)|lung(365)|meninges(18)|oesophagus(239)|ovary(98)|pancreas(263)|pleura(94)|prostate(13)|salivary_gland(10)|skin(541)|small_intestine(1)|soft_tissue(93)|stomach(48)|thymus(4)|thyroid(24)|upper_aerodigestive_tract(436)|urinary_tract(283)|vulva(2)	4199		all_cancers(5;0)|Acute lymphoblastic leukemia(3;0)|all_hematologic(3;0)|all_epithelial(2;2.37e-290)|Lung NSC(2;1.26e-139)|all_lung(2;4.48e-131)|Glioma(2;3.26e-60)|all_neural(2;2.1e-52)|Renal(3;1.07e-46)|Esophageal squamous(3;3.83e-46)|Melanoma(2;2.74e-34)|Breast(3;1.14e-11)|Ovarian(3;0.000128)|Hepatocellular(5;0.00162)|Colorectal(97;0.172)		all cancers(2;0)|GBM - Glioblastoma multiforme(3;0)|Lung(2;4.07e-74)|Epithelial(2;1.08e-61)|LUSC - Lung squamous cell carcinoma(2;3.82e-48)|LUAD - Lung adenocarcinoma(2;4.56e-26)|OV - Ovarian serous cystadenocarcinoma(39;7.64e-10)|BRCA - Breast invasive adenocarcinoma(2;5.01e-09)|STAD - Stomach adenocarcinoma(4;4.63e-07)|Kidney(2;5.79e-07)|KIRC - Kidney renal clear cell carcinoma(2;7.27e-07)|COAD - Colon adenocarcinoma(8;5.15e-05)		TCATCATGACCTGCCAGAGAG	0.667000		17								HNSCC(2;<9.43e_08)|TSP Lung(5;3.83e-07)			14	6					0	0	1	0	0
SERPINB7	8710	broad.mit.edu	37	18	61471558	61471558	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr18:61471558C>G	ENST00000398019.2	+	8	1157	c.832C>G	c.(832-834)Cag>Gag	p.Q278E	SERPINB7_ENST00000540675.1_Missense_Mutation_p.Q261E|SERPINB7_ENST00000336429.2_Missense_Mutation_p.Q278E|SERPINB7_ENST00000546027.1_Missense_Mutation_p.Q278E	NM_003784.3	NP_003775.1	O75635	SPB7_HUMAN	serpin peptidase inhibitor, clade B (ovalbumin), member 7	278					regulation of proteolysis	cytoplasm	serine-type endopeptidase inhibitor activity			central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(3)|lung(14)|prostate(1)|skin(3)	27		Esophageal squamous(42;0.129)				ATTTTTTCCTCAGTTCAAGAT	0.358000													18	28					0	0	1	0	0
PLEKHA7	144100	broad.mit.edu	37	11	16838501	16838501	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr11:16838501G>A	ENST00000355661.3	-	11	1722	c.1712C>T	c.(1711-1713)tCg>tTg	p.S571L	PLEKHA7_ENST00000531066.1_Missense_Mutation_p.S571L|PLEKHA7_ENST00000448080.2_Missense_Mutation_p.S571L|PLEKHA7_ENST00000532079.1_Intron			Q6IQ23	PKHA7_HUMAN	pleckstrin homology domain containing, family A member 7	571	Interaction with CTNND1.|Pro-rich.				epithelial cell-cell adhesion|zonula adherens maintenance	centrosome|zonula adherens	delta-catenin binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(7)|lung(13)|ovary(1)|prostate(2)|skin(7)|urinary_tract(1)	37						AGGGATGTCCGAGGGAGATGG	0.662000													25	19					0	0	1	0	0
OR5B12	390191	broad.mit.edu	37	11	58206945	58206945	+	Missense_Mutation	SNP	C	C	T	rs139365126		TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr11:58206945C>T	ENST00000302572.2	-	1	701	c.680G>A	c.(679-681)cGc>cAc	p.R227H		NM_001004733.2	NP_001004733.1	Q96R08	OR5BC_HUMAN	olfactory receptor, family 5, subfamily B, member 12	227					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(6)|liver(1)|lung(28)|ovary(1)|prostate(3)|skin(1)	40	Esophageal squamous(5;0.0027)	Breast(21;0.0778)				TTCAGGTGAGCGCATCTTCAT	0.403000													33	22					0	0	1	0	0
TMEM132A	54972	broad.mit.edu	37	11	60694876	60694876	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr11:60694876T>C	ENST00000005286.4	+	2	454	c.301T>C	c.(301-303)Ttt>Ctt	p.F101L	TMEM132A_ENST00000453848.2_Missense_Mutation_p.F101L	NM_017870.3|NM_178031.2	NP_060340.2|NP_821174.1	Q24JP5	T132A_HUMAN	transmembrane protein 132A	101						endoplasmic reticulum membrane|Golgi membrane|integral to membrane				breast(1)|cervix(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(14)|ovary(3)|prostate(1)|skin(3)	32						CTACCCACCTTTTGCCACTCA	0.632000													10	50					0	0	1	0	0
PPP1R13L	10848	broad.mit.edu	37	19	45885853	45885853	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr19:45885853C>G	ENST00000418234.2	-	12	2458	c.2380G>C	c.(2380-2382)Gag>Cag	p.E794Q	PPP1R13L_ENST00000360957.5_Missense_Mutation_p.E794Q	NM_001142502.1	NP_001135974.1	Q8WUF5	IASPP_HUMAN	protein phosphatase 1, regulatory subunit 13 like	794	SH3.				apoptosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	transcription corepressor activity|transcription factor binding			breast(1)|endometrium(4)|kidney(1)|large_intestine(1)|lung(14)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	26		all_neural(266;0.224)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.0182)		TCGGTCTCCTCCGGCCCGTCC	0.701000													24	34					0	0	1	0	0
FADS2	9415	broad.mit.edu	37	11	61615710	61615710	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr11:61615710T>C	ENST00000278840.4	+	5	1328	c.698T>C	c.(697-699)gTg>gCg	p.V233A	FADS2_ENST00000521849.1_Missense_Mutation_p.V233A|FADS2_ENST00000522056.1_Missense_Mutation_p.V202A|FADS2_ENST00000257261.6_Missense_Mutation_p.V211A	NM_004265.2	NP_004256.1	O95864	FADS2_HUMAN	fatty acid desaturase 2	233					electron transport chain|transport|unsaturated fatty acid biosynthetic process	endoplasmic reticulum membrane|integral to plasma membrane|membrane fraction	heme binding			breast(2)|kidney(2)|large_intestine(4)|liver(1)|lung(2)|ovary(2)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	20					Alpha-Linolenic Acid(DB00132)	GATCCCGATGTGAACATGCTG	0.567000													43	49					0	0	1	0	0
EBF1	1879	broad.mit.edu	37	5	158126150	158126150	+	Splice_Site	SNP	G	G	A			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr5:158126150G>A	ENST00000313708.6	-	16	2027	c.1745C>T	c.(1744-1746)gCg>gTg	p.A582V	EBF1_ENST00000380654.4_Splice_Site_p.A551V|EBF1_ENST00000517373.1_Splice_Site_p.A514V|EBF1_ENST00000518836.1_5'UTR	NM_024007.3	NP_076870.1	Q9UH73	COE1_HUMAN	early B-cell factor 1	582					multicellular organismal development	nucleus	DNA binding|metal ion binding		HMGA2/EBF1(2)	breast(3)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(7)|lung(18)|ovary(1)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	42	Renal(175;0.00196)	Acute lymphoblastic leukemia(3;2.99e-06)|all_hematologic(3;0.000772)|Medulloblastoma(196;0.037)|all_neural(177;0.143)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			GCCAGATATCGCTATGAAAGA	0.348000			T	HMGA2	lipoma								12	27					0	0	1	0	0
NRG3	10718	broad.mit.edu	37	10	84745042	84745042	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr10:84745042G>A	ENST00000372142.2	+	11	1455	c.1181G>A	c.(1180-1182)gGg>gAg	p.G394E	NRG3_ENST00000404547.1_Missense_Mutation_p.G615E|NRG3_ENST00000404576.2_Missense_Mutation_p.G395E|NRG3_ENST00000556918.1_Missense_Mutation_p.G421E|NRG3_ENST00000537893.1_Missense_Mutation_p.G241E|NRG3_ENST00000372141.2_Missense_Mutation_p.G591E|NRG3_ENST00000545131.1_Missense_Mutation_p.G241E	NM_001165973.1	NP_001159445.1	P56975	NRG3_HUMAN	neuregulin 3	615					regulation of cell growth	extracellular region|integral to plasma membrane	growth factor activity|receptor tyrosine kinase binding|transmembrane receptor protein tyrosine kinase activator activity	p.G591E(1)		breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(41)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	69				GBM - Glioblastoma multiforme(1;2.5e-18)|all cancers(1;2.85e-09)		CAAATGCCAGGGATTTCTGAA	0.463000													33	51					0	0	1	0	0
PIGU	128869	broad.mit.edu	37	20	33173345	33173345	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr20:33173345G>C	ENST00000374820.2	-	8	782	c.762C>G	c.(760-762)ttC>ttG	p.F254L	PIGU_ENST00000452740.2_Missense_Mutation_p.F274L|PIGU_ENST00000480175.1_Intron			Q9H490	PIGU_HUMAN	phosphatidylinositol glycan anchor biosynthesis, class U	274					attachment of GPI anchor to protein|C-terminal protein lipidation|regulation of JAK-STAT cascade	GPI-anchor transamidase complex|plasma membrane				NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(1)|lung(1)|skin(1)	9						AGAAGTACCAGAAAAGACCAA	0.388000													47	69					0	0	1	0	0
LOC101927079	101927079	broad.mit.edu	37	15	22332594	22332594	+	RNA	SNP	T	T	A			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr15:22332594T>A	ENST00000558896.1	+	0	401																											CTATGTATTATTTTTTAGGTC	0.398000													37	166					0	0	1	0	0
PPP1R3A	5506	broad.mit.edu	37	7	113558512	113558512	+	Silent	SNP	T	T	C			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr7:113558512T>C	ENST00000284601.3	-	1	608	c.540A>G	c.(538-540)tcA>tcG	p.S180S		NM_002711.3	NP_002702.2	Q16821	PPR3A_HUMAN	protein phosphatase 1, regulatory subunit 3A	180	CBM21.				glycogen metabolic process	integral to membrane				NS(2)|breast(8)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(14)|liver(1)|lung(43)|ovary(10)|pancreas(7)|prostate(3)|skin(15)|stomach(1)|upper_aerodigestive_tract(2)	121						CACCATCACATGAATTAGGAA	0.328000													11	66					0	0	1	0	0
TNN	63923	broad.mit.edu	37	1	175096139	175096139	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr1:175096139G>T	ENST00000239462.4	+	13	3076	c.2963G>T	c.(2962-2964)gGt>gTt	p.G988V		NM_022093.1	NP_071376.1	Q9UQP3	TENN_HUMAN	tenascin N	988	Fibronectin type-III 9.				cell growth|cell migration|signal transduction	extracellular space|proteinaceous extracellular matrix				NS(1)|central_nervous_system(2)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(29)|liver(1)|lung(81)|ovary(5)|prostate(6)|skin(5)|stomach(4)|upper_aerodigestive_tract(3)|urinary_tract(3)	156		Breast(1374;0.000962)		KIRC - Kidney renal clear cell carcinoma(1967;0.00198)		ACGCAGTCTGGTGGCATATTG	0.498000													26	40					7.41945e-09	8.07209e-09	1	1	0
NOD2	64127	broad.mit.edu	37	16	50733835	50733835	+	Silent	SNP	C	C	T			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr16:50733835C>T	ENST00000300589.2	+	2	615	c.510C>T	c.(508-510)atC>atT	p.I170I	NOD2_ENST00000526417.2_3'UTR	NM_022162.1	NP_071445.1	Q9HC29	NOD2_HUMAN	nucleotide-binding oligomerization domain containing 2	170	CARD 2.				activation of MAPK activity involved in innate immune response|cytokine production involved in immune response|detection of bacterium|detection of muramyl dipeptide|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of macrophage apoptosis|nucleotide-binding oligomerization domain containing 2 signaling pathway|positive regulation of B cell activation|positive regulation of dendritic cell antigen processing and presentation|positive regulation of epithelial cell proliferation|positive regulation of ERK1 and ERK2 cascade|positive regulation of gamma-delta T cell activation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-1 beta secretion|positive regulation of interleukin-10 production|positive regulation of interleukin-17 production|positive regulation of interleukin-6 production|positive regulation of JNK cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of Notch signaling pathway|positive regulation of phosphatidylinositol 3-kinase activity|positive regulation of prostaglandin-E synthase activity|positive regulation of prostaglandin-endoperoxide synthase activity|positive regulation of stress-activated MAPK cascade|positive regulation of tumor necrosis factor production|positive regulation of type 2 immune response|protein oligomerization|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cell surface|cytosol|plasma membrane|vesicle	ATP binding|CARD domain binding|muramyl dipeptide binding|protein kinase binding			cervix(1)|endometrium(5)|kidney(3)|large_intestine(7)|lung(30)|ovary(3)|skin(3)	52		all_cancers(37;0.0156)				GTGATGAAATCAGGTTGCCGA	0.552000													20	34					0	0	1	0	0
LRRN1	57633	broad.mit.edu	37	3	3888132	3888132	+	Nonsense_Mutation	SNP	C	C	T			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr3:3888132C>T	ENST00000319331.3	+	2	2568	c.1807C>T	c.(1807-1809)Cag>Tag	p.Q603*	SUMF1_ENST00000534863.1_Intron	NM_020873.5	NP_065924.3	Q6UXK5	LRRN1_HUMAN	leucine rich repeat neuronal 1	603	Fibronectin type-III.					integral to membrane				NS(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(9)|prostate(1)|skin(1)|urinary_tract(2)	26				Epithelial(13;0.000886)|all cancers(10;0.0032)|OV - Ovarian serous cystadenocarcinoma(96;0.00608)|STAD - Stomach adenocarcinoma(44;0.0617)		CAATATTCATCAGCAGACTCA	0.458000													48	83					0	0	1	0	0
SYNE1	23345	broad.mit.edu	37	6	152774651	152774651	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr6:152774651T>C	ENST00000495090.2	-	12	1806	c.1798A>G	c.(1798-1800)Aaa>Gaa	p.K600E	SYNE1_ENST00000341594.5_Intron|SYNE1_ENST00000367253.4_Intron|SYNE1_ENST00000423061.1_Intron|SYNE1_ENST00000448038.1_Intron|SYNE1_ENST00000413186.2_Intron|SYNE1_ENST00000265368.4_Intron|SYNE1_ENST00000367255.5_Intron|SYNE1_ENST00000367248.3_Intron			Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	7269					cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			NS(3)|biliary_tract(1)|breast(17)|central_nervous_system(21)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(4)|kidney(16)|large_intestine(138)|liver(1)|lung(190)|ovary(11)|pancreas(5)|prostate(12)|skin(20)|stomach(3)|upper_aerodigestive_tract(33)|urinary_tract(19)	524		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		CTCTTACATTTGGACCTTAAC	0.393000										HNSCC(10;0.0054)			34	42					0	0	1	0	0
DESI2	51029	broad.mit.edu	37	1	244855254	244855254	+	Nonsense_Mutation	SNP	G	G	T			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr1:244855254G>T	ENST00000302550.11	+	4	662	c.283G>T	c.(283-285)Gaa>Taa	p.E95*	DESI2_ENST00000263831.7_Nonsense_Mutation_p.E62*	NM_016076.3	NP_057160.2	Q9BSY9	PPDE1_HUMAN	desumoylating isopeptidase 2	95	PPPDE peptidase.																ACTGGGAAAAGAATACAAAGG	0.308000													4	47					0.00024832	0.000255944	1	1	0
POLQ	10721	broad.mit.edu	37	3	121260199	121260199	+	Silent	SNP	G	G	C			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr3:121260199G>C	ENST00000264233.5	-	3	599	c.471C>G	c.(469-471)ctC>ctG	p.L157L		NM_199420.3	NP_955452.3	O75417	DPOLQ_HUMAN	polymerase (DNA directed), theta	157	Helicase ATP-binding.				DNA repair|DNA replication	nucleoplasm	ATP binding|ATP-dependent helicase activity|damaged DNA binding|DNA-directed DNA polymerase activity|single-stranded DNA-dependent ATPase activity			NS(2)|breast(7)|central_nervous_system(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(16)|lung(55)|ovary(5)|prostate(3)|skin(4)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(2)	120				GBM - Glioblastoma multiforme(114;0.0915)		ACATTACCTGGAGGTAGTATT	0.338000								DNA polymerases (catalytic subunits)					48	110					0	0	1	0	0
CEND1	51286	broad.mit.edu	37	11	788405	788405	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr11:788405C>T	ENST00000330106.4	-	2	347	c.172G>A	c.(172-174)Gca>Aca	p.A58T	CEND1_ENST00000524587.1_5'UTR	NM_016564.3	NP_057648.2	Q8N111	CEND_HUMAN	cell cycle exit and neuronal differentiation 1	58						integral to membrane				prostate(1)	1		all_cancers(49;1.13e-08)|all_epithelial(84;2.95e-05)|Breast(177;0.000286)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.159)|all_lung(207;0.198)		all cancers(45;6.27e-26)|Epithelial(43;4.84e-25)|OV - Ovarian serous cystadenocarcinoma(40;2.72e-19)|BRCA - Breast invasive adenocarcinoma(625;4.23e-05)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)		TTGGCAGGTGCCGTGGTGGGG	0.672000													4	98					0	0	1	0	0
CELA3B	23436	broad.mit.edu	37	1	22307332	22307332	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr1:22307332G>A	ENST00000337107.6	+	3	164	c.145G>A	c.(145-147)Gag>Aag	p.E49K		NM_007352.2	NP_031378.1	P08861	CEL3B_HUMAN	chymotrypsin-like elastase family, member 3B	49	Peptidase S1.				cholesterol metabolic process|proteolysis	extracellular region	serine-type endopeptidase activity			breast(2)|kidney(2)|large_intestine(1)|lung(1)|ovary(1)|urinary_tract(1)	8						CCTGCAGTATGAGAAAAGCGG	0.592000											OREG0013210	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	5	20					0	0	1	0	0
ACP2	53	broad.mit.edu	37	11	47264601	47264601	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr11:47264601G>C	ENST00000256997.3	-	9	1046	c.930C>G	c.(928-930)tgC>tgG	p.C310W	ACP2_ENST00000525230.1_5'UTR|ACP2_ENST00000529444.1_Missense_Mutation_p.C247W|ACP2_ENST00000533929.1_Missense_Mutation_p.C282W|ACP2_ENST00000537863.1_Missense_Mutation_p.C123W|ACP2_ENST00000527256.1_Missense_Mutation_p.C278W	NM_001610.2	NP_001601.1	P11117	PPAL_HUMAN	acid phosphatase 2, lysosomal	310						integral to membrane|lysosomal lumen|lysosomal membrane	acid phosphatase activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(2)|ovary(1)|prostate(1)	10						CAAATATGTGGCAGGAGGCGT	0.617000													16	71					0	0	1	0	0
FNDC3B	64778	broad.mit.edu	37	3	172028627	172028627	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr3:172028627G>A	ENST00000336824.4	+	11	1309	c.1210G>A	c.(1210-1212)Gac>Aac	p.D404N	FNDC3B_ENST00000416957.1_Missense_Mutation_p.D404N|FNDC3B_ENST00000415807.2_Missense_Mutation_p.D404N	NM_001135095.1	NP_001128567.1	Q53EP0	FND3B_HUMAN	fibronectin type III domain containing 3B	404	Fibronectin type-III 2.					endoplasmic reticulum|integral to membrane				breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(12)|lung(26)|ovary(3)|prostate(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(1)	69	all_cancers(22;1.01e-18)|Ovarian(172;0.00167)|Breast(254;0.165)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)	GBM - Glioblastoma multiforme(1;0.0494)		GGCACCAATTGACAACGGTTC	0.343000													36	86					0	0	1	0	0
C14orf159	80017	broad.mit.edu	37	14	91662818	91662818	+	Splice_Site	SNP	G	G	A			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr14:91662818G>A	ENST00000518868.1	+	13	1985	c.1295G>A	c.(1294-1296)aGa>aAa	p.R432K	C14orf159_ENST00000521077.2_Splice_Site_p.R432K|C14orf159_ENST00000428926.2_Splice_Site_p.R427K|C14orf159_ENST00000412671.2_Splice_Site_p.R432K|C14orf159_ENST00000522322.1_Splice_Site_p.R427K|C14orf159_ENST00000523771.1_Splice_Site_p.R427K|C14orf159_ENST00000256324.10_Splice_Site_p.R432K|C14orf159_ENST00000525393.2_Splice_Site_p.R303K|C14orf159_ENST00000523816.1_Splice_Site_p.R427K|C14orf159_ENST00000520328.1_Splice_Site_p.R415K			Q7Z3D6	CN159_HUMAN	chromosome 14 open reading frame 159	427						mitochondrion				NS(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(5)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	21		all_cancers(154;0.0191)|all_epithelial(191;0.241)		Epithelial(152;0.141)|OV - Ovarian serous cystadenocarcinoma(161;0.207)		CAGACACCTAGGTACGTATGT	0.517000													3	14					0	0	1	0	0
FAM65C	140876	broad.mit.edu	37	20	49221267	49221267	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr20:49221267C>T	ENST00000327979.2	-	12	1400	c.989G>A	c.(988-990)gGc>gAc	p.G330D	FAM65C_ENST00000045083.2_Missense_Mutation_p.G330D|FAM65C_ENST00000535356.1_Missense_Mutation_p.G334D			Q96MK2	FA65C_HUMAN	family with sequence similarity 65, member C	330										endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|liver(1)|lung(12)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	29						AGAAAACTTGCCCGTGGGGCT	0.592000													3	51					0	0	1	0	0
RNGTT	8732	broad.mit.edu	37	6	89388103	89388103	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr6:89388103C>G	ENST00000369485.4	-	14	1661	c.1475G>C	c.(1474-1476)gGa>gCa	p.G492A	RNGTT_ENST00000369475.3_Missense_Mutation_p.G492A|RNGTT_ENST00000538899.1_Missense_Mutation_p.G409A|RNGTT_ENST00000265607.6_Missense_Mutation_p.G469A	NM_003800.3	NP_003791.3	O60942	MCE1_HUMAN	RNA guanylyltransferase and 5'-phosphatase	492	GTase.				interspecies interaction between organisms|mRNA capping|transcription from RNA polymerase II promoter|viral reproduction	nucleoplasm	GTP binding|mRNA guanylyltransferase activity|polynucleotide 5'-phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			endometrium(1)|large_intestine(7)|lung(6)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)	21		all_cancers(76;4.07e-09)|Prostate(29;1.16e-10)|Acute lymphoblastic leukemia(125;1.49e-10)|all_hematologic(105;7.79e-07)|all_epithelial(107;6.86e-05)		BRCA - Breast invasive adenocarcinoma(108;0.151)		TTCATAACCTCCAACATACAG	0.328000													23	27					0	0	1	0	0
FATE1	89885	broad.mit.edu	37	X	150885800	150885800	+	Nonsense_Mutation	SNP	G	G	T			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chrX:150885800G>T	ENST00000370350.3	+	2	248	c.163G>T	c.(163-165)Gaa>Taa	p.E55*		NM_033085.2	NP_149076.1	Q969F0	FATE1_HUMAN	fetal and adult testis expressed 1	55						endoplasmic reticulum|integral to membrane				NS(1)|breast(1)|cervix(1)|endometrium(3)|large_intestine(2)|lung(6)|ovary(1)	15	Acute lymphoblastic leukemia(192;6.56e-05)					GCAGAAGTTGGAACAAAAAGC	0.517000													5	145					0.014758	0.0149488	1	1	0
SCUBE3	222663	broad.mit.edu	37	6	35211499	35211499	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr6:35211499C>G	ENST00000274938.7	+	16	2038	c.2038C>G	c.(2038-2040)Cct>Gct	p.P680A	SCUBE3_ENST00000394681.1_Missense_Mutation_p.P696A	NM_152753.2	NP_689966.2	Q8IX30	SCUB3_HUMAN	signal peptide, CUB domain, EGF-like 3	680					protein heterooligomerization|protein homooligomerization	cell surface|extracellular region	calcium ion binding|protein binding			breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(12)|lung(11)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	37						TGCCCACGGGCCTCTTGGAGC	0.632000													12	31					0	0	1	0	0
MESP2	145873	broad.mit.edu	37	15	90320328	90320328	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr15:90320328C>A	ENST00000341735.3	+	1	740	c.740C>A	c.(739-741)gCa>gAa	p.A247E	MESP2_ENST00000558723.1_Intron|MESP2_ENST00000560219.1_Intron	NM_001039958.1	NP_001035047.1	Q0VG99	MESP2_HUMAN	mesoderm posterior 2 homolog (mouse)	247					Notch signaling pathway	nucleus	DNA binding			kidney(1)|large_intestine(2)|lung(1)|skin(1)|upper_aerodigestive_tract(1)	6	Lung NSC(78;0.0221)|all_lung(78;0.0448)		BRCA - Breast invasive adenocarcinoma(143;0.0146)|KIRC - Kidney renal clear cell carcinoma(17;0.0286)|Kidney(142;0.0514)			GATCCCTGGGCAACACCCCCT	0.697000													5	10					1.024e-07	1.10894e-07	1	1	0
SIX6	4990	broad.mit.edu	37	14	60976257	60976257	+	Silent	SNP	C	C	T			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr14:60976257C>T	ENST00000327720.5	+	1	589	c.141C>T	c.(139-141)ctC>ctT	p.L47L		NM_007374.2	NP_031400.2	O95475	SIX6_HUMAN	SIX homeobox 6	47					organ morphogenesis|visual perception	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|autonomic_ganglia(1)|endometrium(3)|kidney(1)|large_intestine(3)|lung(2)	11				OV - Ovarian serous cystadenocarcinoma(108;0.088)		GCGAGGCCCTCAACAAGAATG	0.622000													24	22					0	0	1	0	0
PRKD1	5587	broad.mit.edu	37	14	30066936	30066936	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr14:30066936C>T	ENST00000331968.5	-	16	2424	c.2195G>A	c.(2194-2196)cGg>cAg	p.R732Q	PRKD1_ENST00000415220.2_Missense_Mutation_p.R740Q	NM_002742.2	NP_002733.2	Q15139	KPCD1_HUMAN	protein kinase D1	732	Protein kinase.				cell proliferation|intracellular signal transduction|sphingolipid metabolic process	cytosol|integral to plasma membrane	ATP binding|metal ion binding|protein binding|protein kinase C activity	p.R732L(2)		NS(1)|breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(21)|lung(32)|ovary(2)|prostate(1)|skin(4)|urinary_tract(2)	78	Hepatocellular(127;0.0604)		LUAD - Lung adenocarcinoma(48;0.00527)|Lung(238;0.0252)	GBM - Glioblastoma multiforme(265;0.00888)		TCCAATGATCCGGGCAAAACC	0.478000													15	44					0	0	1	0	0
BICD2	23299	broad.mit.edu	37	9	95480849	95480849	+	Missense_Mutation	SNP	A	A	G			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr9:95480849A>G	ENST00000356884.6	-	5	2145	c.2078T>C	c.(2077-2079)cTg>cCg	p.L693P	BICD2_ENST00000375512.3_Missense_Mutation_p.L693P	NM_001003800.1	NP_001003800.1	Q8TD16	BICD2_HUMAN	bicaudal D homolog 2 (Drosophila)	693	Interacts with RAB6A (By similarity).				microtubule anchoring at microtubule organizing center|minus-end-directed organelle transport along microtubule	cytoplasmic vesicle|cytoskeleton|Golgi apparatus|plasma membrane	Rab GTPase binding			cervix(3)|endometrium(4)|kidney(1)|large_intestine(6)|lung(5)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	23						CACAGTGCGCAGCGTGGTGAT	0.612000													37	63					0	0	1	0	0
TAF1L	138474	broad.mit.edu	37	9	32631912	32631912	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr9:32631912C>A	ENST00000242310.4	-	1	3755	c.3666G>T	c.(3664-3666)gaG>gaT	p.E1222D		NM_153809.2	NP_722516.1	Q8IZX4	TAF1L_HUMAN	TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 210kDa-like	1222					male meiosis|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription initiation, DNA-dependent	transcription factor TFIID complex	DNA binding|histone acetyltransferase activity|protein serine/threonine kinase activity|TBP-class protein binding			breast(6)|central_nervous_system(4)|endometrium(14)|kidney(11)|large_intestine(32)|liver(2)|lung(68)|ovary(2)|pancreas(2)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(1)	159			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.00301)		GAATGAATTTCTCATCTTTTG	0.453000													13	173					1.02788e-11	1.12875e-11	1	1	0
ENPP5	59084	broad.mit.edu	37	6	46129186	46129186	+	Silent	SNP	G	G	A			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr6:46129186G>A	ENST00000371383.2	-	5	1571	c.1311C>T	c.(1309-1311)gtC>gtT	p.V437V	ENPP5_ENST00000230565.3_Silent_p.V437V			Q9UJA9	ENPP5_HUMAN	ectonucleotide pyrophosphatase/phosphodiesterase 5 (putative)	437						extracellular region|integral to membrane	hydrolase activity			endometrium(3)|kidney(1)|large_intestine(3)|lung(4)|upper_aerodigestive_tract(1)	12						TGCCAAGAGAGACCCCTATGA	0.388000													23	35					0	0	1	0	0
LGALS12	85329	broad.mit.edu	37	11	63283815	63283815	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr11:63283815C>T	ENST00000415491.2	+	8	1392	c.778C>T	c.(778-780)Cgg>Tgg	p.R260W	LGALS12_ENST00000340246.5_Missense_Mutation_p.R322W|LGALS12_ENST00000394618.3_Missense_Mutation_p.R321W|LGALS12_ENST00000255684.5_Missense_Mutation_p.R312W|LGALS12_ENST00000425950.2_Missense_Mutation_p.R251W	NM_001142537.1	NP_001136009.1	Q96DT0	LEG12_HUMAN	lectin, galactoside-binding, soluble, 12	321	Galectin 2.				apoptosis|induction of apoptosis by intracellular signals	nucleus	lactose binding			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(2)|upper_aerodigestive_tract(1)	16						GGAGCAGCTGCGGGAGCTCCG	0.622000													3	54					0	0	1	0	0
CASKIN2	57513	broad.mit.edu	37	17	73500695	73500695	+	Silent	SNP	G	G	C			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr17:73500695G>C	ENST00000321617.3	-	12	1858	c.1272C>G	c.(1270-1272)ggC>ggG	p.G424G	CASKIN2_ENST00000433559.2_Silent_p.G342G	NM_020753.3	NP_065804.2	Q8WXE0	CSKI2_HUMAN	CASK interacting protein 2	424						cytoplasm				endometrium(1)|kidney(3)|lung(7)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(1)	18	all_cancers(13;3.15e-09)|all_epithelial(9;5.78e-10)|Breast(9;5.8e-10)|all_lung(278;0.246)		all cancers(21;4.57e-07)|Epithelial(20;2.92e-06)|Lung(188;0.0809)|LUSC - Lung squamous cell carcinoma(166;0.154)			GGCCATTAGTGCCCTCAGAGC	0.642000													3	19					0	0	1	0	0
CLUH	23277	broad.mit.edu	37	17	2607715	2607715	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr17:2607715G>C	ENST00000570628.2	-	2	235	c.130C>G	c.(130-132)Cag>Gag	p.Q44E	CLUH_ENST00000435359.1_Missense_Mutation_p.Q44E|CLUH_ENST00000538975.1_Missense_Mutation_p.Q44E					clustered mitochondria (cluA/CLU1) homolog																		CCCGTGTCCTGAATGACAATG	0.642000													3	6					0	0	1	0	0
DCDC2	51473	broad.mit.edu	37	6	24205370	24205370	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr6:24205370G>T	ENST00000378450.3	-	1	161	c.142C>A	c.(142-144)Caa>Aaa	p.Q48K	DCDC2_ENST00000378454.3_Intron			Q9UHG0	DCDC2_HUMAN	doublecortin domain containing 2	76	Doublecortin 1.				cellular defense response|intracellular signal transduction|neuron migration					breast(1)|endometrium(2)|kidney(3)|large_intestine(8)|lung(12)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	32		Ovarian(999;0.101)				AAATCCAATTGTGACATCGTG	0.403000													8	61					0.000157383	0.000163651	1	1	0
ARHGEF11	9826	broad.mit.edu	37	1	156925550	156925550	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr1:156925550C>A	ENST00000368194.3	-	20	2752	c.1713G>T	c.(1711-1713)aaG>aaT	p.K571N	ARHGEF11_ENST00000361409.2_Missense_Mutation_p.K531N	NM_198236.2	NP_937879.1	O15085	ARHGB_HUMAN	Rho guanine nucleotide exchange factor (GEF) 11	531					actin cytoskeleton organization|apoptosis|axon guidance|cellular component movement|cytokinesis|establishment of cell polarity|G-protein coupled receptor protein signaling pathway|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|positive regulation of transcription, DNA-dependent|regulation of cell growth|regulation of Rho protein signal transduction|Rho protein signal transduction|striated muscle contraction	cytosol|Golgi apparatus|plasma membrane	G-protein-coupled receptor binding|GTPase activator activity|Rho guanyl-nucleotide exchange factor activity|signal transducer activity			NS(1)|breast(3)|central_nervous_system(3)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(15)|lung(27)|ovary(4)|pancreas(2)|pleura(1)|prostate(4)|skin(7)|stomach(1)|urinary_tract(2)	81	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					GGTTTCGCTTCTTGTCCTCCA	0.517000													144	193					1.6827e-80	1.91958e-80	1	1	0
C12orf52	84934	broad.mit.edu	37	12	113624824	113624824	+	Silent	SNP	C	C	G			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr12:113624824C>G	ENST00000548278.1	+	3	965	c.273C>G	c.(271-273)acC>acG	p.T91T	C12orf52_ENST00000552495.1_Silent_p.T115T|C12orf52_ENST00000549621.1_Silent_p.T91T|RP11-545P7.4_ENST00000552525.1_RNA	NM_032848.1	NP_116237.1	Q96K30	RITA_HUMAN	chromosome 12 open reading frame 52	91					negative regulation of Notch signaling pathway|negative regulation of transcription from RNA polymerase II promoter|neurogenesis|Notch signaling pathway|nuclear export	centrosome|nucleus	tubulin binding	p.L92F(1)		large_intestine(2)|lung(1)|prostate(1)|urinary_tract(1)	5						GCACCCCCACCCTCACACCAA	0.562000													8	9					0	0	1	0	0
COL14A1	7373	broad.mit.edu	37	8	121381667	121381667	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr8:121381667C>T	ENST00000297848.3	+	47	5524	c.5254C>T	c.(5254-5256)Cct>Tct	p.P1752S	COL14A1_ENST00000309791.4_Missense_Mutation_p.P1752S|COL14A1_ENST00000247781.3_Missense_Mutation_p.P1657S	NM_021110.1	NP_066933.1	Q05707	COEA1_HUMAN	collagen, type XIV, alpha 1	1752	Triple-helical region 2 (COL1).				cell-cell adhesion|collagen fibril organization	collagen type XIV|extracellular space	collagen binding|extracellular matrix structural constituent|protein binding, bridging			NS(1)|autonomic_ganglia(1)|breast(11)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(9)|large_intestine(31)|lung(42)|ovary(5)|pancreas(1)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)	119	Lung NSC(37;6.52e-07)|Ovarian(258;0.00769)|Hepatocellular(40;0.161)		OV - Ovarian serous cystadenocarcinoma(1;6.47e-38)|STAD - Stomach adenocarcinoma(47;0.00503)			ACCCCAAGGTCCTTCTGGCCA	0.592000													30	45					0	0	1	0	0
C10orf2	56652	broad.mit.edu	37	10	102748438	102748438	+	Silent	SNP	C	C	T			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr10:102748438C>T	ENST00000370228.1	+	1	656	c.471C>T	c.(469-471)atC>atT	p.I157I	C10orf2_ENST00000311916.2_Silent_p.I157I|C10orf2_ENST00000473656.1_Intron	NM_001163812.1|NM_001163814.1	NP_001157284.1|NP_001157286.1	Q96RR1	PEO1_HUMAN	chromosome 10 open reading frame 2	157					cell death|mitochondrial DNA replication|protein hexamerization|protein homooligomerization|transcription from mitochondrial promoter	mitochondrial nucleoid	5'-3' DNA helicase activity|ATP binding|protease binding|single-stranded DNA binding			breast(3)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(10)|ovary(1)|skin(1)|stomach(1)	24		Colorectal(252;0.122)|all_hematologic(284;0.152)		Epithelial(162;7.18e-11)|all cancers(201;8.75e-09)|BRCA - Breast invasive adenocarcinoma(275;0.224)		TCCGGAGGATCTGGAACCGAG	0.572000													43	99					0	0	1	0	0
ASTN2	23245	broad.mit.edu	37	9	119976926	119976926	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr9:119976926C>A	ENST00000313400.4	-	3	826	c.726G>T	c.(724-726)aaG>aaT	p.K242N	ASTN2_ENST00000361209.2_Missense_Mutation_p.K242N|ASTN2_ENST00000361477.3_5'UTR|ASTN2_ENST00000373996.3_Missense_Mutation_p.K242N			O75129	ASTN2_HUMAN	astrotactin 2	242						integral to membrane				breast(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(21)|lung(45)|ovary(4)|pancreas(2)|prostate(2)|skin(9)|stomach(1)|urinary_tract(1)	102						TGCTTGCGCTCTTCTGGGGGA	0.642000													33	39					3.90053e-15	4.34419e-15	1	1	0
SLC38A3	10991	broad.mit.edu	37	3	50255397	50255397	+	RNA	SNP	G	G	A			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr3:50255397G>A	ENST00000420502.1	+	0	1057							Q99624	S38A3_HUMAN	solute carrier family 38, member 3						cellular nitrogen compound metabolic process|sodium ion transport	integral to plasma membrane	antiporter activity|L-alanine transmembrane transporter activity|L-asparagine transmembrane transporter activity|L-glutamine transmembrane transporter activity|L-histidine transmembrane transporter activity|symporter activity			breast(1)|cervix(1)|endometrium(1)|lung(3)	6				BRCA - Breast invasive adenocarcinoma(193;0.000275)|KIRC - Kidney renal clear cell carcinoma(197;0.00548)|Kidney(197;0.00615)	L-Asparagine(DB00174)|L-Glutamine(DB00130)|L-Histidine(DB00117)	CTGCCACCCCGAGGTGCTGCC	0.607000													14	30					0	0	1	0	0
MYH8	4626	broad.mit.edu	37	17	10295278	10295278	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr17:10295278T>C	ENST00000403437.2	-	39	5679	c.5585A>G	c.(5584-5586)aAg>aGg	p.K1862R	RP11-799N11.1_ENST00000581304.1_RNA|RP11-799N11.1_ENST00000399342.2_RNA|CTC-297N7.11_ENST00000587182.2_RNA	NM_002472.2	NP_002463.2	P13535	MYH8_HUMAN	myosin, heavy chain 8, skeletal muscle, perinatal	1862					muscle filament sliding	cytosol|muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			NS(3)|breast(8)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(61)|ovary(3)|prostate(3)|skin(10)|upper_aerodigestive_tract(2)|urinary_tract(2)	134						GAGAACATTCTTGCGATCTTC	0.388000									Trismus-Pseudocamptodactyly Syndrome with Cardiac Myxoma and Freckling				12	132					0	0	1	0	0
PPP2R2A	5520	broad.mit.edu	37	8	26217721	26217721	+	Missense_Mutation	SNP	A	A	T			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr8:26217721A>T	ENST00000380737.3	+	5	712	c.383A>T	c.(382-384)gAc>gTc	p.D128V	PPP2R2A_ENST00000315985.7_Missense_Mutation_p.D138V	NM_002717.3	NP_002708.1			protein phosphatase 2, regulatory subunit B, alpha											kidney(1)|large_intestine(2)|ovary(1)	4		all_cancers(63;0.086)|Ovarian(32;2.61e-05)|all_epithelial(46;0.0514)|Prostate(55;0.157)		UCEC - Uterine corpus endometrioid carcinoma (27;0.000754)|Epithelial(17;3.02e-15)|all cancers(2;1.52e-13)|OV - Ovarian serous cystadenocarcinoma(2;1.89e-10)|Colorectal(74;0.155)		AGTGAAAGGGACAAAAGACCA	0.313000													22	59					0	0	1	0	0
POLR3E	55718	broad.mit.edu	37	16	22335849	22335849	+	Missense_Mutation	SNP	T	T	A			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr16:22335849T>A	ENST00000299853.5	+	16	1321	c.1154T>A	c.(1153-1155)tTc>tAc	p.F385Y	POLR3E_ENST00000418581.2_Missense_Mutation_p.F349Y|POLR3E_ENST00000359210.4_Missense_Mutation_p.F385Y|POLR3E_ENST00000564209.1_Missense_Mutation_p.F385Y	NM_001258033.1|NM_001258035.1|NM_018119.3	NP_001244962.1|NP_001244964.1|NP_060589.1	Q9NVU0	RPC5_HUMAN	polymerase (RNA) III (DNA directed) polypeptide E (80kD)	385					innate immune response|response to virus|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase III promoter	nucleoplasm	DNA-directed RNA polymerase activity			central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(7)|lung(10)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	27				GBM - Glioblastoma multiforme(48;0.012)		GTGAAGGACTTCCTGGAGCAC	0.627000													49	94					0	0	1	0	0
RUNX1	861	broad.mit.edu	37	21	36259264	36259264	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr21:36259264C>T	ENST00000344691.4	-	1	1723	c.146G>A	c.(145-147)cGc>cAc	p.R49H	RUNX1_ENST00000399240.1_Missense_Mutation_p.R49H|RUNX1_ENST00000325074.5_Missense_Mutation_p.R64H|RUNX1_ENST00000300305.3_Missense_Mutation_p.R76H|RUNX1_ENST00000437180.1_Missense_Mutation_p.R76H|RUNX1_ENST00000358356.5_Missense_Mutation_p.R49H|RUNX1_ENST00000486278.2_Missense_Mutation_p.R52H	NM_001001890.2	NP_001001890.1	Q01196	RUNX1_HUMAN	runt-related transcription factor 1	49					myeloid cell differentiation|negative regulation of granulocyte differentiation|positive regulation of angiogenesis|positive regulation of granulocyte differentiation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent	nucleus	ATP binding|calcium ion binding|DNA binding|protein binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|transcription factor binding	p.R76H(1)		breast(5)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(428)|large_intestine(3)|lung(6)|oesophagus(4)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	452						CACCATGCTGCGGTCGCCGCT	0.726000			T	"""RPL22, MDS1, EVI1, CBFA2T3, CBFA2T1, ETV6, LAF4"""	"""AML, preB- ALL, T-ALL"""								3	18					0	0	1	0	0
LRP4	4038	broad.mit.edu	37	11	46880573	46880573	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr11:46880573C>G	ENST00000378623.1	-	38	5921	c.5679G>C	c.(5677-5679)tgG>tgC	p.W1893C	LRP4-AS1_ENST00000531719.1_RNA|LRP4-AS1_ENST00000502049.2_RNA	NM_002334.3	NP_002325.2	O75096	LRP4_HUMAN	low density lipoprotein receptor-related protein 4	1893					endocytosis|negative regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	integral to membrane	calcium ion binding|receptor activity			breast(7)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(13)|lung(24)|ovary(3)|pancreas(2)|prostate(5)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)	70				Lung(87;0.159)		GTTCATGTTTCCAGCCCGTGT	0.542000													40	26					0	0	1	0	0
RLTPR	146206	broad.mit.edu	37	16	67686228	67686228	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr16:67686228G>C	ENST00000334583.6	+	27	3131	c.2803G>C	c.(2803-2805)Gag>Cag	p.E935Q	RLTPR_ENST00000545661.1_Missense_Mutation_p.E899Q	NM_001013838.1	NP_001013860.1	Q6F5E8	LR16C_HUMAN	RGD motif, leucine rich repeats, tropomodulin domain and proline-rich containing	935	Pro-rich.									breast(1)|cervix(1)|endometrium(4)|kidney(1)|lung(9)|urinary_tract(2)	18		Acute lymphoblastic leukemia(13;3.23e-05)|all_hematologic(13;0.00251)|Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0146)|Epithelial(162;0.0481)|all cancers(182;0.232)		ggagaaggaagaggagaagga	0.557000													14	25					0	0	1	0	0
NPFFR2	10886	broad.mit.edu	37	4	73012900	73012900	+	Missense_Mutation	SNP	A	A	T			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr4:73012900A>T	ENST00000308744.6	+	4	1038	c.940A>T	c.(940-942)Aat>Tat	p.N314Y	NPFFR2_ENST00000358749.3_Missense_Mutation_p.N212Y|NPFFR2_ENST00000395999.1_Missense_Mutation_p.N215Y|NPFFR2_ENST00000506359.1_3'UTR|NPFFR2_ENST00000344413.5_3'UTR	NM_004885.2	NP_004876.2	Q9Y5X5	NPFF2_HUMAN	neuropeptide FF receptor 2	314					detection of abiotic stimulus	actin cytoskeleton|integral to plasma membrane	neuropeptide receptor activity			NS(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(24)|ovary(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	43			Lung(101;0.0935)|LUSC - Lung squamous cell carcinoma(112;0.138)			AGACTGGCCAAATCAGGAAAT	0.453000													26	14					0	0	1	0	0
TOMM40L	84134	broad.mit.edu	37	1	161197699	161197699	+	Nonsense_Mutation	SNP	G	G	A			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr1:161197699G>A	ENST00000367988.3	+	6	673	c.404G>A	c.(403-405)tGg>tAg	p.W135*	TOMM40L_ENST00000545897.1_Nonsense_Mutation_p.W101*|TOMM40L_ENST00000474486.1_3'UTR|TOMM40L_ENST00000367987.1_Nonsense_Mutation_p.W135*	NM_032174.4	NP_115550.2	Q969M1	TM40L_HUMAN	translocase of outer mitochondrial membrane 40 homolog (yeast)-like	135					protein transport	mitochondrial outer membrane|pore complex	porin activity|voltage-gated anion channel activity			large_intestine(2)|liver(4)|lung(4)	10	all_cancers(52;1.86e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00376)			TTCCTGACATGGCAGTTTGAT	0.527000											OREG0013943	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	18	19					0	0	1	0	0
CREBBP	1387	broad.mit.edu	37	16	3824690	3824690	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr16:3824690C>T	ENST00000262367.5	-	12	2972	c.2163G>A	c.(2161-2163)atG>atA	p.M721I	CREBBP_ENST00000382070.3_Missense_Mutation_p.M683I	NM_004380.2	NP_004371.2	Q92793	CBP_HUMAN	CREB binding protein	721					cellular lipid metabolic process|homeostatic process|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|protein complex assembly|response to hypoxia	cytoplasm|nuclear body	histone acetyltransferase activity|MyoD binding|p53 binding|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription coactivator activity|zinc ion binding			NS(1)|breast(5)|central_nervous_system(4)|cervix(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(125)|kidney(5)|large_intestine(32)|lung(43)|ovary(18)|pancreas(2)|prostate(6)|skin(9)|soft_tissue(1)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(21)	295		Ovarian(90;0.0266)		OV - Ovarian serous cystadenocarcinoma(1;3.54e-05)		TAAATGAATTCATCCCTGTAA	0.443000			"""T, N, F, Mis, O"""	"""MLL, MORF, RUNXBP2"""	"""ALL, AML, DLBCL, B-NHL """		Rubinstein-Taybi syndrome						11	29					0	0	1	0	0
COPZ1	22818	broad.mit.edu	37	12	54743440	54743440	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr12:54743440C>G	ENST00000262061.2	+	8	521	c.484C>G	c.(484-486)Cag>Gag	p.Q162E	COPZ1_ENST00000552218.1_Missense_Mutation_p.Q183E|COPZ1_ENST00000549043.1_Missense_Mutation_p.Q170E|COPZ1_ENST00000553231.1_Missense_Mutation_p.Q139E|COPZ1_ENST00000548281.1_3'UTR|COPZ1_ENST00000549116.1_Missense_Mutation_p.Q104E|COPZ1_ENST00000455864.2_Missense_Mutation_p.Q139E|COPZ1_ENST00000548753.1_Missense_Mutation_p.Q74E|COPZ1_ENST00000552362.1_Intron|COPZ1_ENST00000551779.1_Missense_Mutation_p.Q162E|COPZ1_ENST00000416254.2_Missense_Mutation_p.Q111E	NM_001271734.1|NM_001271736.1|NM_016057.1	NP_001258663.1|NP_001258665.1|NP_057141.1	P61923	COPZ1_HUMAN	coatomer protein complex, subunit zeta 1	162					COPI coating of Golgi vesicle|intra-Golgi vesicle-mediated transport|intracellular protein transport|retrograde vesicle-mediated transport, Golgi to ER	COPI vesicle coat|cytosol				kidney(1)|lung(4)	5						GACCGTGTCTCAGGTATGACT	0.483000													59	149					0	0	1	0	0
ARC	23237	broad.mit.edu	37	8	143694471	143694471	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr8:143694471C>T	ENST00000356613.2	-	1	2362	c.1162G>A	c.(1162-1164)Gtg>Atg	p.V388M		NM_015193.4	NP_056008.1	Q7LC44	ARC_HUMAN	activity-regulated cytoskeleton-associated protein	388					endocytosis	acrosomal vesicle|cell junction|dendritic spine|endosome|postsynaptic density|postsynaptic membrane				breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(4)|lung(3)|upper_aerodigestive_tract(1)	13	all_cancers(97;3.55e-12)|all_epithelial(106;1.03e-08)|Lung NSC(106;0.000353)|all_lung(105;0.00092)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)	Acute lymphoblastic leukemia(644;0.0279)				TCACTGGCCACGGACTCGCTG	0.701000													6	5					0	0	1	0	0
RYR3	6263	broad.mit.edu	37	15	33955919	33955919	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr15:33955919G>A	ENST00000389232.4	+	36	5670	c.5600G>A	c.(5599-5601)cGc>cAc	p.R1867H	RYR3_ENST00000415757.3_Missense_Mutation_p.R1867H	NM_001036.3	NP_001027.3	Q15413	RYR3_HUMAN	ryanodine receptor 3	1867	4 X approximate repeats.				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(3)|breast(9)|central_nervous_system(8)|cervix(2)|endometrium(29)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(55)|lung(148)|ovary(7)|pancreas(1)|prostate(13)|skin(4)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(3)	311		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		AAGGAGTTCCGCTCACCCCCA	0.557000													7	4					0	0	1	0	0
ZNF527	84503	broad.mit.edu	37	19	37879873	37879873	+	Nonsense_Mutation	SNP	G	G	T			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr19:37879873G>T	ENST00000436120.2	+	5	1029	c.922G>T	c.(922-924)Gga>Tga	p.G308*	ZNF527_ENST00000587349.1_Intron	NM_032453.1	NP_115829.1	Q8NB42	ZN527_HUMAN	zinc finger protein 527	308					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(14)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	33			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			CAATGACTGTGGAAAAGCCTT	0.393000													19	54					8.00594e-06	8.47476e-06	1	1	0
LAMB3	3914	broad.mit.edu	37	1	209789835	209789835	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr1:209789835C>G	ENST00000391911.1	-	21	3752	c.3363G>C	c.(3361-3363)gaG>gaC	p.E1121D	LAMB3_ENST00000356082.4_Missense_Mutation_p.E1121D|LAMB3_ENST00000367030.3_Missense_Mutation_p.E1121D	NM_001017402.1	NP_001017402.1	Q13751	LAMB3_HUMAN	laminin, beta 3	1121	Domain I.				cell adhesion|epidermis development|hemidesmosome assembly		structural molecule activity			NS(1)|breast(3)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(11)|lung(13)|ovary(1)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	45				OV - Ovarian serous cystadenocarcinoma(81;0.0519)		TGTCCATCATCTCCATGGTCT	0.562000													48	116					0	0	1	0	0
TENM3	55714	broad.mit.edu	37	4	183664436	183664436	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr4:183664436G>C	ENST00000511685.1	+	19	3616	c.3493G>C	c.(3493-3495)Ggt>Cgt	p.G1165R	TENM3_ENST00000406950.2_Missense_Mutation_p.G1165R|TENM3_ENST00000502950.1_3'UTR					teneurin transmembrane protein 3																		CAGTTGCAATGGTCAAGCTGA	0.547000													8	26					0	0	1	0	0
ZNF462	58499	broad.mit.edu	37	9	109771843	109771843	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr9:109771843G>A	ENST00000277225.5	+	12	7496	c.7207G>A	c.(7207-7209)Gac>Aac	p.D2403N	ZNF462_ENST00000457913.1_Missense_Mutation_p.D2463N|ZNF462_ENST00000542028.1_Missense_Mutation_p.D360N|RP11-508N12.2_ENST00000439901.1_RNA|ZNF462_ENST00000441147.2_Missense_Mutation_p.D1309N			Q96JM2	ZN462_HUMAN	zinc finger protein 462	2403					transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(2)|autonomic_ganglia(2)|breast(5)|central_nervous_system(4)|cervix(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(17)|large_intestine(20)|lung(32)|ovary(5)|prostate(6)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	119						GAGATTTTCTGACCACGGGGC	0.473000													20	19					0	0	1	0	0
KLHL4	56062	broad.mit.edu	37	X	86773256	86773256	+	Silent	SNP	T	T	C			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chrX:86773256T>C	ENST00000373119.4	+	1	505	c.360T>C	c.(358-360)tgT>tgC	p.C120C	KLHL4_ENST00000373114.4_Silent_p.C120C	NM_019117.4	NP_061990.2	Q9C0H6	KLHL4_HUMAN	kelch-like family member 4	120						cytoplasm|microtubule cytoskeleton|nucleolus	actin binding			NS(1)|biliary_tract(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(19)|lung(29)|ovary(2)|prostate(1)|skin(1)	67						AAGAAGCTTGTGAGAAACGCG	0.373000													46	13					0	0	1	0	0
RPF1	80135	broad.mit.edu	37	1	84955382	84955382	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr1:84955382C>G	ENST00000370654.5	+	4	448	c.433C>G	c.(433-435)Ctc>Gtc	p.L145V		NM_025065.6	NP_079341.2	Q9H9Y2	RPF1_HUMAN	ribosome production factor 1 homolog (S. cerevisiae)	145	Brix.				rRNA processing|translation	nucleolus	aminoacyl-tRNA ligase activity|ATP binding|rRNA binding			breast(2)|endometrium(1)|kidney(3)|large_intestine(5)|lung(2)|prostate(1)	14						TCCCAAGATTCTCATCACAAC	0.328000													7	33					0	0	1	0	0
HPS6	79803	broad.mit.edu	37	10	103826396	103826396	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr10:103826396G>A	ENST00000299238.5	+	1	1250	c.1165G>A	c.(1165-1167)Gaa>Aaa	p.E389K		NM_024747.5	NP_079023.2	Q86YV9	HPS6_HUMAN	Hermansky-Pudlak syndrome 6	389						cytosol|early endosome membrane|endoplasmic reticulum|microsome				endometrium(1)|kidney(1)|large_intestine(4)|lung(4)|prostate(1)	11		Colorectal(252;0.122)		Epithelial(162;5.93e-08)|all cancers(201;1.03e-06)		TGTGGGCTGGGAAGCCCCACA	0.622000									Hermansky-Pudlak syndrome				26	31					0	0	1	0	0
LRRC3	81543	broad.mit.edu	37	21	45876836	45876836	+	Missense_Mutation	SNP	C	C	G	rs150321502		TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr21:45876836C>G	ENST00000291592.4	+	2	626	c.309C>G	c.(307-309)atC>atG	p.I103M		NM_030891.3	NP_112153.1	Q9BY71	LRRC3_HUMAN	leucine rich repeat containing 3	103						integral to membrane	protein binding			endometrium(2)|kidney(1)|lung(1)|urinary_tract(1)	5		Breast(209;0.00908)		COAD - Colon adenocarcinoma(84;0.148)|Lung(125;0.195)		TCGAGGCCATCGGCTCCGCCA	0.662000													4	37					0	0	1	0	0
SMTNL2	342527	broad.mit.edu	37	17	4496425	4496425	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr17:4496425G>A	ENST00000389313.4	+	3	756	c.689G>A	c.(688-690)aGc>aAc	p.S230N	SMTNL2_ENST00000338859.4_Missense_Mutation_p.S86N	NM_001114974.1	NP_001108446.1	Q2TAL5	SMTL2_HUMAN	smoothelin-like 2	230										breast(1)|endometrium(9)|kidney(1)|lung(1)|skin(1)	13				READ - Rectum adenocarcinoma(115;0.0325)		CTCAACCCAAGCCCCAGCGAG	0.647000													35	34					0	0	1	0	0
DLL4	54567	broad.mit.edu	37	15	41221880	41221880	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr15:41221880C>T	ENST00000249749.5	+	1	290	c.14C>T	c.(13-15)tCc>tTc	p.S5F		NM_019074.3	NP_061947.1	Q9NR61	DLL4_HUMAN	delta-like 4 (Drosophila)	5					blood circulation|cell communication|cell differentiation|Notch receptor processing|Notch signaling pathway	integral to membrane|plasma membrane	calcium ion binding|Notch binding			breast(3)|large_intestine(1)	4		all_cancers(109;1.35e-17)|all_epithelial(112;3.78e-15)|Lung NSC(122;9.68e-11)|all_lung(180;2.25e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.0946)		GBM - Glioblastoma multiforme(113;1.07e-05)|COAD - Colon adenocarcinoma(120;0.15)|BRCA - Breast invasive adenocarcinoma(123;0.164)		GCGGCAGCGTCCCGGAGCGCC	0.731000													4	9					0	0	1	0	0
BBS9	27241	broad.mit.edu	37	7	33397598	33397598	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr7:33397598C>T	ENST00000242067.6	+	16	2205	c.1684C>T	c.(1684-1686)Ctc>Ttc	p.L562F	BBS9_ENST00000355070.2_Missense_Mutation_p.L557F|BBS9_ENST00000354265.4_Missense_Mutation_p.L527F|BBS9_ENST00000396127.2_Missense_Mutation_p.L527F|BBS9_ENST00000350941.3_Missense_Mutation_p.L522F	NM_198428.2	NP_940820.1	Q3SYG4	PTHB1_HUMAN	Bardet-Biedl syndrome 9	562					fat cell differentiation|response to stimulus|visual perception	BBSome|cilium membrane|microtubule organizing center|nucleus	protein binding		BBS9/PKD1L1(2)	NS(1)|autonomic_ganglia(1)|endometrium(1)|kidney(2)|large_intestine(7)|lung(27)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	50			GBM - Glioblastoma multiforme(11;0.0894)			TCTTCTTAGTCTCTTCCCAGG	0.383000									Bardet-Biedl syndrome				39	31					0	0	1	0	0
NOSTRIN	115677	broad.mit.edu	37	2	169707825	169707825	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr2:169707825G>C	ENST00000444448.2	+	13	1413	c.937G>C	c.(937-939)Gac>Cac	p.D313H	NOSTRIN_ENST00000397209.2_Missense_Mutation_p.D228H|NOSTRIN_ENST00000421711.2_Missense_Mutation_p.D228H|NOSTRIN_ENST00000397206.2_Missense_Mutation_p.D178H|NOSTRIN_ENST00000445023.2_Missense_Mutation_p.D178H|NOSTRIN_ENST00000458381.2_Missense_Mutation_p.D313H|NOSTRIN_ENST00000317647.7_Missense_Mutation_p.D256H			Q8IVI9	NOSTN_HUMAN	nitric oxide synthase trafficking	256					endocytosis|nitric oxide metabolic process|regulation of nitric-oxide synthase activity	cytoplasmic membrane-bounded vesicle|cytoskeleton|plasma membrane	protein binding			kidney(1)|large_intestine(1)|lung(4)|prostate(1)|skin(1)|urinary_tract(1)	9						CAGCAAGATTGACATTGAAAA	0.418000													18	19					0	0	1	0	0
EFR3A	23167	broad.mit.edu	37	8	132957121	132957121	+	Splice_Site	SNP	T	T	C			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr8:132957121T>C	ENST00000254624.5	+	3	440		c.e3+2		EFR3A_ENST00000334503.4_Splice_Site|EFR3A_ENST00000519656.1_Splice_Site	NM_015137.4	NP_055952.2	Q14156	EFR3A_HUMAN	EFR3 homolog A (S. cerevisiae)							plasma membrane	binding			breast(2)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(6)|lung(14)|ovary(3)|skin(1)|stomach(2)	35	Esophageal squamous(12;0.00693)|Ovarian(258;0.00769)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000805)|LUAD - Lung adenocarcinoma(14;0.102)			TCGTTCTGGGTAAGGAAACTA	0.358000													4	19					0	0	1	0	0
PPP4R1	9989	broad.mit.edu	37	18	9553350	9553350	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr18:9553350C>T	ENST00000400556.3	-	16	2334	c.2261G>A	c.(2260-2262)aGa>aAa	p.R754K	PPP4R1_ENST00000400555.3_Missense_Mutation_p.R737K	NM_001042388.2	NP_001035847.1	Q8TF05	PP4R1_HUMAN	protein phosphatase 4, regulatory subunit 1	754					protein phosphorylation|signal transduction	protein phosphatase 4 complex	protein binding|protein phosphatase type 4 regulator activity			large_intestine(1)|skin(2)	3						CCGCCAATTTCTACTATTATC	0.303000													17	23					0	0	1	0	0
ZMYND15	84225	broad.mit.edu	37	17	4645341	4645341	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr17:4645341G>A	ENST00000433935.1	+	4	1016	c.959G>A	c.(958-960)aGc>aAc	p.S320N	ZMYND15_ENST00000573751.2_Missense_Mutation_p.S320N|ZMYND15_ENST00000592813.1_Missense_Mutation_p.S320N|ZMYND15_ENST00000269289.6_Missense_Mutation_p.S320N	NM_001136046.2|NM_001267822.1	NP_001129518.1|NP_001254751.1	Q9H091	ZMY15_HUMAN	zinc finger, MYND-type containing 15	320							zinc ion binding			endometrium(5)|large_intestine(3)|lung(6)|ovary(1)|prostate(1)|skin(2)	18						CACAGGCACAGCTTTGAAGCG	0.592000													46	93					0	0	1	0	0
RECQL4	9401	broad.mit.edu	37	8	145739638	145739638	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr8:145739638C>T	ENST00000428558.2	-	11	1854	c.1813G>A	c.(1813-1815)Gat>Aat	p.D605N	RECQL4_ENST00000532237.1_5'UTR	NM_004260.3	NP_004251.3	O94761	RECQ4_HUMAN	RecQ protein-like 4	605	Helicase ATP-binding.				DNA duplex unwinding|DNA recombination|DNA repair	cytoplasm|nucleus	ATP binding|ATP-dependent 3'-5' DNA helicase activity|bubble DNA binding|DNA strand annealing activity|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(5)|kidney(1)|lung(10)|ovary(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)	26	all_cancers(97;5.56e-11)|all_epithelial(106;3.54e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.48e-41)|Epithelial(56;1.85e-40)|all cancers(56;3.59e-35)|BRCA - Breast invasive adenocarcinoma(115;0.0483)|Colorectal(110;0.055)			TGGGCCTCATCAATGCAGGCA	0.647000			"""N, F, S"""			"""osteosarcoma, skin basal and sqamous cell"""		Genes defective in diseases associated with sensitivity to DNA damaging agents	Rothmund-Thomson syndrome;RAPADILINO syndrome;Baller-Gerold syndrome				13	43					0	0	1	0	0
LRRC47	57470	broad.mit.edu	37	1	3703459	3703459	+	Missense_Mutation	SNP	A	A	G			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr1:3703459A>G	ENST00000378251.1	-	2	1058	c.1031T>C	c.(1030-1032)aTg>aCg	p.M344T		NM_020710.2	NP_065761.1	Q8N1G4	LRC47_HUMAN	leucine rich repeat containing 47	344					translation		phenylalanine-tRNA ligase activity|RNA binding			central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(5)|ovary(2)|prostate(1)|urinary_tract(1)	17	all_cancers(77;0.0375)|Ovarian(185;0.0634)|all_lung(157;0.208)|Lung NSC(156;0.21)	all_epithelial(116;1.34e-16)|all_lung(118;2.53e-06)|Lung NSC(185;0.00028)|Renal(390;0.00357)|Breast(487;0.00446)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Lung SC(97;0.0743)|Ovarian(437;0.127)		Epithelial(90;5.49e-39)|OV - Ovarian serous cystadenocarcinoma(86;1.43e-22)|GBM - Glioblastoma multiforme(42;3.69e-16)|Colorectal(212;1.21e-05)|COAD - Colon adenocarcinoma(227;5.87e-05)|Kidney(185;0.000367)|BRCA - Breast invasive adenocarcinoma(365;0.000704)|KIRC - Kidney renal clear cell carcinoma(229;0.00567)|STAD - Stomach adenocarcinoma(132;0.00645)|Lung(427;0.124)		CTGCAGGTCCATGCCTCGCAC	0.642000													3	4					0	0	1	0	0
KEAP1	9817	broad.mit.edu	37	19	10602872	10602872	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr19:10602872C>T	ENST00000171111.5	-	3	1253	c.706G>A	c.(706-708)Gac>Aac	p.D236N	KEAP1_ENST00000588024.1_5'UTR|KEAP1_ENST00000393623.2_Missense_Mutation_p.D236N	NM_203500.1	NP_987096.1	Q14145	KEAP1_HUMAN	kelch-like ECH-associated protein 1	236	BACK.		D -> H (in a NSCLC cell line).		regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|midbody|nucleus	protein binding			breast(3)|endometrium(2)|kidney(4)|large_intestine(4)|liver(2)|lung(69)|ovary(2)|pancreas(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	92			OV - Ovarian serous cystadenocarcinoma(20;2.71e-09)|Epithelial(33;2.32e-06)|all cancers(31;1.42e-05)			ACGTTCAGGTCGTCCCGGCTG	0.622000													25	37					0	0	1	0	0
ATP13A5	344905	broad.mit.edu	37	3	193068958	193068958	+	Silent	SNP	G	G	A			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr3:193068958G>A	ENST00000342358.4	-	7	756	c.639C>T	c.(637-639)ttC>ttT	p.F213F		NM_198505.2	NP_940907.2	Q4VNC0	AT135_HUMAN	ATPase type 13A5	213					ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			NS(1)|autonomic_ganglia(2)|breast(1)|endometrium(6)|kidney(4)|large_intestine(15)|liver(2)|lung(26)|ovary(5)|prostate(1)|skin(10)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	76	all_cancers(143;1.08e-08)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(49;5.56e-18)|LUSC - Lung squamous cell carcinoma(58;6.08e-06)|Lung(62;6.49e-06)	GBM - Glioblastoma multiforme(46;0.000307)		AAGTTAGGGTGAAGGCTTGGA	0.398000													33	59					0	0	1	0	0
MTFR1L	56181	broad.mit.edu	37	1	26153142	26153142	+	Silent	SNP	C	C	T			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr1:26153142C>T	ENST00000466284.1	+	4	1858	c.276C>T	c.(274-276)ccC>ccT	p.P92P	MTFR1L_ENST00000474295.1_Silent_p.P92P|MTFR1L_ENST00000374300.3_Silent_p.P92P|MTFR1L_ENST00000374303.2_Silent_p.P92P|MTFR1L_ENST00000524618.1_5'UTR|MTFR1L_ENST00000374307.5_Silent_p.P92P|MTFR1L_ENST00000526894.1_Silent_p.P92P|MTFR1L_ENST00000374301.3_Silent_p.P92P|MTFR1L_ENST00000469815.1_Intron					mitochondrial fission regulator 1-like																		CCTGGAAACCCAGCCCTCTGA	0.582000													33	98					0	0	1	0	0
ITGA2B	3674	broad.mit.edu	37	17	42462348	42462348	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr17:42462348G>T	ENST00000262407.5	-	7	798	c.767C>A	c.(766-768)tCc>tAc	p.S256Y	ITGA2B_ENST00000353281.4_Missense_Mutation_p.S256Y|ITGA2B_ENST00000377068.3_Intron	NM_000419.3	NP_000410.2	P08514	ITA2B_HUMAN	integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)	256					axon guidance|integrin-mediated signaling pathway|platelet activation|platelet degranulation	integrin complex|platelet alpha granule membrane	identical protein binding|receptor activity			biliary_tract(1)|breast(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(7)|lung(8)|ovary(4)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	36		Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.191)	Tirofiban(DB00775)	TGGGTTGCTGGAGTCAAAGGA	0.607000													15	89					2.23348e-06	2.38577e-06	1	1	0
CNTN3	5067	broad.mit.edu	37	3	74350893	74350893	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr3:74350893G>T	ENST00000263665.6	-	14	1877	c.1850C>A	c.(1849-1851)tCt>tAt	p.S617Y		NM_020872.1	NP_065923.1	Q9P232	CNTN3_HUMAN	contactin 3 (plasmacytoma associated)	617	Fibronectin type-III 1.				cell adhesion	anchored to membrane|plasma membrane	protein binding			NS(2)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(39)|ovary(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	83		Lung NSC(201;0.138)|Lung SC(41;0.21)		Epithelial(33;0.00212)|BRCA - Breast invasive adenocarcinoma(55;0.00258)|LUSC - Lung squamous cell carcinoma(21;0.00461)|Lung(16;0.01)		TTCTTTCCAAGAGAGTTGGGC	0.448000													7	40					8.12818e-05	8.48944e-05	1	1	0
TMEM101	84336	broad.mit.edu	37	17	42092225	42092225	+	Silent	SNP	G	G	A			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr17:42092225G>A	ENST00000589334.1	-	2	411	c.96C>T	c.(94-96)ttC>ttT	p.F32F	TMEM101_ENST00000206380.3_Silent_p.F32F|TMEM101_ENST00000587529.1_Silent_p.F32F|TMEM101_ENST00000542039.1_Intron			Q96IK0	TM101_HUMAN	transmembrane protein 101	32					positive regulation of I-kappaB kinase/NF-kappaB cascade	integral to membrane	signal transducer activity			central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(2)|upper_aerodigestive_tract(1)	7		Breast(137;0.0264)|Prostate(33;0.0861)		BRCA - Breast invasive adenocarcinoma(366;0.113)		TGAGCTGGCTGAAGCAGCCCC	0.607000													42	62					0	0	1	0	0
INA	9118	broad.mit.edu	37	10	105037202	105037202	+	Silent	SNP	C	C	T			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr10:105037202C>T	ENST00000369849.4	+	1	283	c.234C>T	c.(232-234)agC>agT	p.S78S		NM_032727.3	NP_116116.1	Q16352	AINX_HUMAN	internexin neuronal intermediate filament protein, alpha	78	Head.				cell differentiation|nervous system development	neurofilament	structural constituent of cytoskeleton			breast(2)|endometrium(2)|large_intestine(2)|lung(4)|ovary(1)|prostate(2)	13				Epithelial(162;3.45e-09)|all cancers(201;9.17e-08)|BRCA - Breast invasive adenocarcinoma(275;0.198)		TGGACCTGAGCCAGGCGGCGG	0.697000													10	20					0	0	1	0	0
C12orf76	400073	broad.mit.edu	37	12	110495088	110495088	+	Nonsense_Mutation	SNP	C	C	A			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr12:110495088C>A	ENST00000309050.5	-	4	569	c.205G>T	c.(205-207)Gag>Tag	p.E69*	C12orf76_ENST00000548936.1_Intron|C12orf76_ENST00000548191.1_Intron	NM_207435.1	NP_997318.1	Q8N812	CL076_HUMAN	chromosome 12 open reading frame 76	69										endometrium(1)|large_intestine(2)|lung(2)|ovary(1)	6						AAGTTCCTCTCCCCCTTACAG	0.512000													6	17					1.26484e-09	1.3825e-09	1	1	0
TP53	7157	broad.mit.edu	37	17	7577094	7577094	+	Missense_Mutation	SNP	G	G	A	rs28934574		TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr17:7577094G>A	ENST00000420246.2	-	8	976	c.844C>T	c.(844-846)Cgg>Tgg	p.R282W	TP53_ENST00000359597.4_Missense_Mutation_p.R282W|TP53_ENST00000455263.2_Missense_Mutation_p.R282W|TP53_ENST00000445888.2_Missense_Mutation_p.R282W|TP53_ENST00000269305.4_Missense_Mutation_p.R282W|TP53_ENST00000413465.2_Intron	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	282	Interaction with AXIN1 (By similarity).|Interaction with E4F1.|Interaction with HIPK1 (By similarity).		DR -> EW (in sporadic cancers; somatic mutation).|R -> G (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> H (in a sporadic cancer; somatic mutation).|R -> L (in sporadic cancers; somatic mutation).|R -> P (in sporadic cancers; somatic mutation).|R -> Q (in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> W (in LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs28934574).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R282W(401)|p.R282G(29)|p.0?(8)|p.R282fs*24(4)|p.R282R(3)|p.?(2)|p.D281fs*63(2)|p.D281_R282>EW(2)|p.A276_R283delACPGRDRR(1)|p.D281_R282insXX(1)|p.C275fs*20(1)|p.R282_E287delRRTEEE(1)|p.L265_K305del41(1)|p.D281_R282delDR(1)|p.G279fs*59(1)|p.R280fs*62(1)|p.S269fs*21(1)|p.R282fs*63(1)|p.V272_K292del21(1)|p.C275_R283delCACPGRDRR(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		TCTGTGCGCCGGTCTCTCCCA	0.557000		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			6	13					0	0	1	0	0
GRIN3A	116443	broad.mit.edu	37	9	104432465	104432465	+	Silent	SNP	C	C	T			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr9:104432465C>T	ENST00000361820.3	-	3	2829	c.2229G>A	c.(2227-2229)agG>agA	p.R743R		NM_133445.2	NP_597702.2	Q8TCU5	NMD3A_HUMAN	glutamate receptor, ionotropic, N-methyl-D-aspartate 3A	743					response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|neuron projection|neuronal cell body|outer membrane-bounded periplasmic space|postsynaptic density|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|glycine binding|identical protein binding|N-methyl-D-aspartate selective glutamate receptor activity|protein phosphatase 2A binding			breast(2)|central_nervous_system(2)|endometrium(4)|kidney(3)|large_intestine(12)|lung(44)|ovary(4)|pancreas(1)|skin(7)|upper_aerodigestive_tract(1)	80		Acute lymphoblastic leukemia(62;0.0568)			Acamprosate(DB00659)|Chloroprocaine(DB01161)|Dextromethorphan(DB00514)|Ethanol(DB00898)|Ethopropazine(DB00392)|Felbamate(DB00949)|Ketamine(DB01221)|L-Glutamic Acid(DB00142)|Memantine(DB01043)|Meperidine(DB00454)|Methadone(DB00333)|Orphenadrine(DB01173)|Procaine(DB00721)|Riluzole(DB00740)	TCATTAGAAACCTTCCAGTCC	0.438000													11	89					0	0	1	0	0
PVRL2	5819	broad.mit.edu	37	19	45375180	45375180	+	Nonsense_Mutation	SNP	C	C	A			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr19:45375180C>A	ENST00000252483.5	+	3	549	c.549C>A	c.(547-549)tgC>tgA	p.C183*	PVRL2_ENST00000252485.4_Nonsense_Mutation_p.C183*	NM_001042724.1	NP_001036189.1	Q92692	PVRL2_HUMAN	poliovirus receptor-related 2 (herpesvirus entry mediator B)	183	Ig-like C2-type 1.				adherens junction organization|adhesion to symbiont|cell junction assembly|homophilic cell adhesion|positive regulation of immunoglobulin mediated immune response|positive regulation of mast cell activation|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target|susceptibility to natural killer cell mediated cytotoxicity|susceptibility to T cell mediated cytotoxicity|viral envelope fusion with host membrane|virion attachment, binding of host cell surface coreceptor	cell surface|integral to membrane|zonula adherens	cell adhesion molecule binding|coreceptor activity|protein homodimerization activity			breast(1)|endometrium(1)|large_intestine(6)|lung(5)	13	Lung NSC(12;0.00195)|all_lung(12;0.00522)	Ovarian(192;0.0728)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.0143)		TGGCCCTCTGCATCTCCAAAG	0.637000													3	39					1	1	1	1	0
DDX24	57062	broad.mit.edu	37	14	94528953	94528953	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr14:94528953G>C	ENST00000330836.5	-	3	864	c.733C>G	c.(733-735)Ctt>Gtt	p.L245V	DDX24_ENST00000544005.1_5'UTR|DDX24_ENST00000555054.1_Missense_Mutation_p.L202V	NM_020414.3	NP_065147.1	Q9GZR7	DDX24_HUMAN	DEAD (Asp-Glu-Ala-Asp) box helicase 24	245	Helicase ATP-binding.				RNA metabolic process	cytoplasm|nucleolus	ATP binding|ATP-dependent RNA helicase activity|protein binding|RNA binding			cervix(3)|endometrium(4)|kidney(4)|large_intestine(5)|lung(3)|ovary(2)|skin(1)|urinary_tract(1)	23		all_cancers(154;0.12)		Epithelial(152;0.114)|all cancers(159;0.19)|COAD - Colon adenocarcinoma(157;0.207)		GCAAAGGCAAGAGTTTTCCCA	0.423000													15	53					0	0	1	0	0
VWA3A	146177	broad.mit.edu	37	16	22143020	22143020	+	Silent	SNP	C	C	A			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr16:22143020C>A	ENST00000389398.5	+	19	1938	c.1842C>A	c.(1840-1842)ctC>ctA	p.L614L	VWA3A_ENST00000389397.4_5'UTR	NM_173615.3	NP_775886.3	A6NCI4	VWA3A_HUMAN	von Willebrand factor A domain containing 3A	614	VWFA 1.					extracellular region				haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(1)|skin(1)	7				GBM - Glioblastoma multiforme(48;0.0439)		GAATCTACCTCTTCACTGGGG	0.582000													9	20					7.48243e-07	8.02909e-07	1	1	0
KRTAP5-6	440023	broad.mit.edu	37	11	1718780	1718780	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr11:1718780C>T	ENST00000382160.1	+	1	356	c.305C>T	c.(304-306)tCa>tTa	p.S102L		NM_001012416.1	NP_001012416.1	Q6L8G9	KRA56_HUMAN	keratin associated protein 5-6	102	6 X 4 AA repeats of C-C-X-P.					keratin filament				endometrium(1)|large_intestine(2)|lung(6)|skin(1)	10		all_epithelial(84;0.00018)|Ovarian(85;0.0014)|Breast(177;0.00147)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00136)|Lung(200;0.0681)|LUSC - Lung squamous cell carcinoma(625;0.082)		GGCTGTGGGTCATCCTGCTGC	0.607000													91	96					0	0	1	0	0
TEP1	7011	broad.mit.edu	37	14	20871927	20871927	+	Silent	SNP	C	C	T			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr14:20871927C>T	ENST00000262715.5	-	6	1189	c.1149G>A	c.(1147-1149)cgG>cgA	p.R383R	TEP1_ENST00000556935.1_Intron	NM_007110.4	NP_009041.2	Q99973	TEP1_HUMAN	telomerase-associated protein 1	383	TROVE.				telomere maintenance via recombination	chromosome, telomeric region|cytoplasm|nuclear matrix|soluble fraction|telomerase holoenzyme complex	ATP binding|RNA binding			NS(4)|breast(1)|central_nervous_system(4)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(48)|ovary(7)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	96	all_cancers(95;0.00123)	all_lung(585;0.235)	Epithelial(56;7.42e-08)|all cancers(55;6.46e-07)	GBM - Glioblastoma multiforme(265;0.028)|READ - Rectum adenocarcinoma(17;0.233)		CCCGGTGCTTCCGAGGGTTGT	0.617000													58	53					0	0	1	0	0
RLTPR	146206	broad.mit.edu	37	16	67686168	67686168	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr16:67686168G>A	ENST00000334583.6	+	27	3071	c.2743G>A	c.(2743-2745)Gag>Aag	p.E915K	RLTPR_ENST00000545661.1_Missense_Mutation_p.E879K	NM_001013838.1	NP_001013860.1	Q6F5E8	LR16C_HUMAN	RGD motif, leucine rich repeats, tropomodulin domain and proline-rich containing	915	Pro-rich.									breast(1)|cervix(1)|endometrium(4)|kidney(1)|lung(9)|urinary_tract(2)	18		Acute lymphoblastic leukemia(13;3.23e-05)|all_hematologic(13;0.00251)|Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0146)|Epithelial(162;0.0481)|all cancers(182;0.232)		GGATGGAGGTGAGCCCAGCCT	0.562000													20	42					0	0	1	0	0
LOC400867	400867	broad.mit.edu	37	21	40250479	40250479	+	RNA	SNP	G	G	C			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr21:40250479G>C	ENST00000380931.2	-	0	2558																											TGTTACCCAAGAGAGCTGTCT	0.522000													6	31					0	0	1	0	0
TOP2B	7155	broad.mit.edu	37	3	25640995	25640995	+	Silent	SNP	C	C	T			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr3:25640995C>T	ENST00000435706.2	-	35	4827	c.4626G>A	c.(4624-4626)agG>agA	p.R1542R	TOP2B_ENST00000540199.1_Silent_p.R399R|TOP2B_ENST00000264331.4_Silent_p.R1547R|TOP2B_ENST00000542520.1_Silent_p.R399R			Q02880	TOP2B_HUMAN	topoisomerase (DNA) II beta 180kDa	1547					DNA topological change|DNA-dependent DNA replication|mitotic cell cycle G2/M transition decatenation checkpoint|mitotic recombination|resolution of meiotic recombination intermediates|sister chromatid segregation	cytosol|DNA topoisomerase complex (ATP-hydrolyzing)|nucleolus|nucleoplasm|synaptonemal complex|WINAC complex	ATP binding|chromatin binding|DNA topoisomerase (ATP-hydrolyzing) activity|DNA-dependent ATPase activity|histone deacetylase binding|protein C-terminus binding|protein heterodimerization activity|protein kinase C binding|sequence-specific DNA binding transcription factor activity			breast(2)|endometrium(5)|kidney(1)|large_intestine(10)|lung(14)|ovary(1)|skin(2)|stomach(1)	36						CAGATGCTTTCCTTTTCTTTG	0.388000													3	13					0	0	1	0	0
GABRE	2564	broad.mit.edu	37	X	151129827	151129827	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chrX:151129827C>T	ENST00000370325.1	-	5	627	c.574G>A	c.(574-576)Gat>Aat	p.D192N	GABRE_ENST00000393914.3_Intron|GABRE_ENST00000370328.3_Missense_Mutation_p.D192N			P78334	GBRE_HUMAN	gamma-aminobutyric acid (GABA) A receptor, epsilon	192					gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(9)|ovary(2)|skin(1)	27	Acute lymphoblastic leukemia(192;6.56e-05)					CATCCGGCATCAATGGTCATC	0.512000													48	9					0	0	1	0	0
LPAR3	23566	broad.mit.edu	37	1	85331503	85331503	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr1:85331503G>A	ENST00000440886.1	-	1	339	c.301C>T	c.(301-303)Cgc>Tgc	p.R101C	LPAR3_ENST00000491034.1_5'UTR|LPAR3_ENST00000370611.3_Missense_Mutation_p.R101C			Q9UBY5	LPAR3_HUMAN	lysophosphatidic acid receptor 3	101					G-protein signaling, coupled to cyclic nucleotide second messenger|synaptic transmission	integral to plasma membrane|intracellular membrane-bounded organelle				central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(11)|ovary(2)|urinary_tract(1)	24						AGAAACCAGCGGTTGACAGTC	0.488000													27	213					0	0	1	0	0
SERPING1	710	broad.mit.edu	37	11	57382031	57382031	+	Nonsense_Mutation	SNP	C	C	T			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr11:57382031C>T	ENST00000403558.1	+	7	1975	c.1609C>T	c.(1609-1611)Cga>Tga	p.R537*	SERPING1_ENST00000378324.2_Nonsense_Mutation_p.R442*|SERPING1_ENST00000278407.4_Nonsense_Mutation_p.R494*|SERPING1_ENST00000378323.4_Nonsense_Mutation_p.R499*|SERPING1_ENST00000340687.6_Nonsense_Mutation_p.R457*	NM_001032295.1	NP_001027466.1	P05155	IC1_HUMAN	serpin peptidase inhibitor, clade G (C1 inhibitor), member 1	494					blood circulation|blood coagulation, intrinsic pathway|complement activation, classical pathway|innate immune response|negative regulation of complement activation, lectin pathway|platelet activation|platelet degranulation	extracellular space|platelet alpha granule lumen	protein binding|serine-type endopeptidase inhibitor activity			central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(7)|lung(11)|pancreas(2)|prostate(1)|urinary_tract(1)	27						CTTCATGGGGCGAGTATATGA	0.617000													16	12					0	0	1	0	0
CDHR1	92211	broad.mit.edu	37	10	85962872	85962872	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr10:85962872C>G	ENST00000372117.3	+	8	879	c.776C>G	c.(775-777)aCc>aGc	p.T259S	CDHR1_ENST00000440770.2_Missense_Mutation_p.T18S|CDHR1_ENST00000332904.3_Missense_Mutation_p.T259S	NM_033100.2	NP_149091.1	Q96JP9	CDHR1_HUMAN	cadherin-related family member 1	259	Cadherin 3.				homophilic cell adhesion		calcium ion binding|receptor activity			breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(6)|liver(1)|lung(21)|ovary(1)|prostate(1)|skin(1)	36						TACGAGGACACCCTTCCGGTG	0.597000													6	60					0	0	1	0	0
PLD1	5337	broad.mit.edu	37	3	171405266	171405266	+	Nonsense_Mutation	SNP	C	C	A			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr3:171405266C>A	ENST00000356327.5	-	15	1718	c.1648G>T	c.(1648-1650)Gga>Tga	p.G550*	PLD1_ENST00000342215.6_Intron|PLD1_ENST00000351298.4_Nonsense_Mutation_p.G550*|PLD1_ENST00000340989.4_Nonsense_Mutation_p.G550*	NM_001130081.2	NP_001123553.1	Q13393	PLD1_HUMAN	phospholipase D1, phosphatidylcholine-specific	550	Catalytic.				cell communication|chemotaxis|Ras protein signal transduction	endoplasmic reticulum membrane|Golgi membrane|late endosome membrane|perinuclear region of cytoplasm	NAPE-specific phospholipase D activity|phosphatidylinositol binding|phospholipase D activity			breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(15)|lung(27)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	63	all_cancers(22;4.53e-19)|Ovarian(172;0.00197)|Breast(254;0.186)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)		Choline(DB00122)	TTTCCTATTCCTTTCAGTTTT	0.428000													37	63					3.93418e-24	4.46634e-24	1	1	0
ROBO1	6091	broad.mit.edu	37	3	78706263	78706263	+	Nonsense_Mutation	SNP	G	G	A			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr3:78706263G>A	ENST00000436010.2	-	16	3479	c.2482C>T	c.(2482-2484)Cag>Tag	p.Q828*	ROBO1_ENST00000495273.1_Nonsense_Mutation_p.Q831*|ROBO1_ENST00000467549.1_Nonsense_Mutation_p.Q831*|ROBO1_ENST00000464233.1_Nonsense_Mutation_p.Q867*			Q9Y6N7	ROBO1_HUMAN	roundabout, axon guidance receptor, homolog 1 (Drosophila)	867	Fibronectin type-III 3.				activation of caspase activity|axon midline choice point recognition|cell migration involved in sprouting angiogenesis|chemorepulsion involved in postnatal olfactory bulb interneuron migration|homophilic cell adhesion|negative regulation of chemokine-mediated signaling pathway|negative regulation of mammary gland epithelial cell proliferation|negative regulation of negative chemotaxis|positive regulation of axonogenesis|Roundabout signaling pathway	cell surface|cytoplasm|integral to plasma membrane	axon guidance receptor activity|identical protein binding|LRR domain binding			breast(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(2)|lung(25)|urinary_tract(1)	44		Lung SC(41;0.0257)|Lung NSC(201;0.0439)		LUSC - Lung squamous cell carcinoma(21;0.008)|Epithelial(33;0.00999)|Lung(72;0.0177)|BRCA - Breast invasive adenocarcinoma(55;0.0274)		TGGATGAACTGAGGCTCACTC	0.527000													6	10					0	0	1	0	0
DMP1	1758	broad.mit.edu	37	4	88583648	88583648	+	Missense_Mutation	SNP	A	A	G			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr4:88583648A>G	ENST00000339673.6	+	6	817	c.718A>G	c.(718-720)Aaa>Gaa	p.K240E	RP11-742B18.1_ENST00000507894.1_RNA|DMP1_ENST00000282479.7_Missense_Mutation_p.K224E|RP11-742B18.1_ENST00000506480.1_RNA	NM_004407.3	NP_004398.1	Q13316	DMP1_HUMAN	dentin matrix acidic phosphoprotein 1	240					biomineral tissue development|ossification	cytoplasm|nucleus|proteinaceous extracellular matrix	calcium ion binding|integrin binding			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(14)|ovary(1)|pancreas(3)|prostate(1)|skin(1)|stomach(1)	32		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.227)		OV - Ovarian serous cystadenocarcinoma(123;0.000516)		CATGAAATCAAAAGAATCTGG	0.478000													20	7					0	0	1	0	0
SLMAP	7871	broad.mit.edu	37	3	57902775	57902775	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr3:57902775G>A	ENST00000295951.3	+	20	3396	c.2179G>A	c.(2179-2181)Gaa>Aaa	p.E727K	SLMAP_ENST00000416870.1_Missense_Mutation_p.E237K|SLMAP_ENST00000449503.2_Missense_Mutation_p.E706K|SLMAP_ENST00000495364.1_Missense_Mutation_p.E278K|SLMAP_ENST00000494088.1_Missense_Mutation_p.E237K|SLMAP_ENST00000428312.1_Missense_Mutation_p.E744K|SLMAP_ENST00000295952.3_Missense_Mutation_p.E727K|SLMAP_ENST00000442599.2_Missense_Mutation_p.E212K			Q14BN4	SLMAP_HUMAN	sarcolemma associated protein	744					muscle contraction|protein folding	integral to plasma membrane|microtubule organizing center|prefoldin complex|sarcolemma|smooth endoplasmic reticulum	unfolded protein binding			endometrium(5)|kidney(1)|large_intestine(3)|lung(7)|urinary_tract(2)	18				BRCA - Breast invasive adenocarcinoma(55;0.000271)|KIRC - Kidney renal clear cell carcinoma(284;0.0602)|Kidney(284;0.0754)|OV - Ovarian serous cystadenocarcinoma(275;0.182)		CAGTAAGGCAGAAAACCAAGC	0.403000													18	38					0	0	1	0	0
DUSP21	63904	broad.mit.edu	37	X	44703756	44703756	+	Silent	SNP	C	C	A			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chrX:44703756C>A	ENST00000339042.4	+	1	508	c.378C>A	c.(376-378)tcC>tcA	p.S126S		NM_022076.3	NP_071359.3	Q9H596	DUS21_HUMAN	dual specificity phosphatase 21	126	Sufficient for mitochondrial localization (By similarity).|Tyrosine-protein phosphatase.					cytoplasm|nucleus	MAP kinase tyrosine/serine/threonine phosphatase activity|protein tyrosine phosphatase activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(3)|lung(8)|skin(3)	19						AATACCACTCCATGTCGCTGC	0.572000													4	72					0.00909568	0.00929341	1	1	0
VCAN	1462	broad.mit.edu	37	5	82817722	82817722	+	Silent	SNP	C	C	T			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr5:82817722C>T	ENST00000265077.3	+	7	4162	c.3597C>T	c.(3595-3597)atC>atT	p.I1199I	VCAN_ENST00000343200.5_Intron|VCAN_ENST00000342785.4_Silent_p.I1199I|VCAN_ENST00000502527.2_Intron|VCAN_ENST00000512590.2_Silent_p.I1151I	NM_004385.4	NP_004376.2	P13611	CSPG2_HUMAN	versican	1199	GAG-alpha (glucosaminoglycan attachment domain).				cell adhesion|cell recognition|glial cell migration	extracellular space|proteinaceous extracellular matrix	calcium ion binding|hyaluronic acid binding|sugar binding			NS(2)|biliary_tract(1)|breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(52)|lung(64)|ovary(8)|pancreas(3)|prostate(13)|skin(14)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(5)	190		Lung NSC(167;0.0216)|all_lung(232;0.0251)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;2.47e-41)|Epithelial(54;2.51e-34)|all cancers(79;5.19e-29)		TTTCAACAATCAAAGTCACAG	0.398000													50	38					0	0	1	0	0
RHCG	51458	broad.mit.edu	37	15	90030205	90030205	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr15:90030205C>T	ENST00000268122.4	-	2	264	c.196G>A	c.(196-198)Gtg>Atg	p.V66M	RHCG_ENST00000544600.1_Missense_Mutation_p.V66M	NM_016321.1	NP_057405.1	Q9UBD6	RHCG_HUMAN	Rh family, C glycoprotein	66					amine transport|cellular ion homeostasis|epithelial cell differentiation|transepithelial ammonium transport	apical plasma membrane|basolateral plasma membrane|cytoplasmic vesicle|integral to plasma membrane	ammonia transmembrane transporter activity|ammonium transmembrane transporter activity|ankyrin binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(9)|upper_aerodigestive_tract(1)|urinary_tract(1)	21	Lung NSC(78;0.0237)|all_lung(78;0.0478)					ATCACGTGCACGTCCTGGAAG	0.657000													5	38					0	0	1	0	0
PCSK7	9159	broad.mit.edu	37	11	117079768	117079768	+	Splice_Site	SNP	G	G	A			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr11:117079768G>A	ENST00000320934.3	-	13	2166	c.1536C>T	c.(1534-1536)gtC>gtT	p.V512V	PCSK7_ENST00000540028.1_Splice_Site_p.V153V	NM_004716.2	NP_004707.2	Q16549	PCSK7_HUMAN	proprotein convertase subtilisin/kexin type 7	512	Homo B/P.				peptide hormone processing	integral to Golgi membrane	serine-type endopeptidase activity			NS(1)|endometrium(3)|large_intestine(2)|lung(8)|ovary(1)|skin(1)	16	all_hematologic(175;0.0487)	Breast(348;0.00908)|Medulloblastoma(222;0.0425)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;1.72e-06)|Epithelial(105;6.71e-05)|all cancers(92;0.000537)		CCATCCTGCTGACTGTAGAAA	0.577000			T	IGH@	MLCLS								5	16					0	0	1	0	0
DGKB	1607	broad.mit.edu	37	7	14217686	14217686	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr7:14217686C>T	ENST00000403951.2	-	24	2635	c.2216G>A	c.(2215-2217)cGg>cAg	p.R739Q	DGKB_ENST00000402815.1_Missense_Mutation_p.R738Q|DGKB_ENST00000399322.3_Missense_Mutation_p.R739Q|DGKB_ENST00000407950.1_Missense_Mutation_p.R731Q|DGKB_ENST00000406247.3_Missense_Mutation_p.R739Q|DGKB_ENST00000444700.2_Missense_Mutation_p.R720Q|DGKB_ENST00000258767.5_Missense_Mutation_p.R739Q			Q9Y6T7	DGKB_HUMAN	diacylglycerol kinase, beta 90kDa	739					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	cytoplasm|plasma membrane	ATP binding|calcium ion binding|diacylglycerol kinase activity|protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|liver(1)|lung(34)|ovary(4)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	72					Phosphatidylserine(DB00144)	CTGAGCCAGCCGCCGGCCAGC	0.507000													14	34					0	0	1	0	0
RPAP2	79871	broad.mit.edu	37	1	92772769	92772769	+	Nonsense_Mutation	SNP	C	C	T			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr1:92772769C>T	ENST00000610020.1	+	6	533	c.424C>T	c.(424-426)Caa>Taa	p.Q142*	RPAP2_ENST00000484158.1_3'UTR	NM_024813.2	NP_079089.2	Q8IXW5	RPAP2_HUMAN	RNA polymerase II associated protein 2							integral to membrane|nucleus	metal ion binding|phosphoprotein phosphatase activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(10)|ovary(1)|pancreas(1)|prostate(1)|skin(1)	22		all_lung(203;0.0565)|Lung NSC(277;0.152)|Glioma(108;0.222)		all cancers(265;0.00647)|GBM - Glioblastoma multiforme(16;0.0234)|Epithelial(280;0.115)		TTTTTGTTATCAAGCATCTAA	0.294000													11	18					0	0	1	0	0
ZNF391	346157	broad.mit.edu	37	6	27368612	27368612	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr6:27368612C>T	ENST00000244576.4	+	3	1008	c.463C>T	c.(463-465)Cat>Tat	p.H155Y		NM_001076781.1	NP_001070249.1	Q9UJN7	ZN391_HUMAN	zinc finger protein 391	155					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(2)|large_intestine(6)|lung(7)|pancreas(2)|skin(3)|upper_aerodigestive_tract(1)	21						CCTTATTGAACATCAAAGAAC	0.398000													7	68					0	0	1	0	0
MYOM3	127294	broad.mit.edu	37	1	24392413	24392413	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr1:24392413C>G	ENST00000330966.7	-	29	3673	c.3511G>C	c.(3511-3513)Gag>Cag	p.E1171Q	MYOM3_ENST00000329601.7_Missense_Mutation_p.E1170Q|MYOM3_ENST00000338909.5_Missense_Mutation_p.E61Q|MYOM3_ENST00000374434.3_Missense_Mutation_p.E1168Q|RP11-293P20.2_ENST00000439239.2_RNA			Q5VTT5	MYOM3_HUMAN	myomesin 3	1168	Ig-like C2-type 3.									NS(2)|breast(2)|central_nervous_system(1)|endometrium(5)|kidney(6)|large_intestine(3)|lung(40)|ovary(2)|prostate(1)|skin(4)|urinary_tract(2)	68		Colorectal(325;3.55e-05)|Renal(390;0.000703)|Lung NSC(340;0.001)|all_lung(284;0.0014)|Ovarian(437;0.00351)|Breast(348;0.0126)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;5.31e-24)|Colorectal(126;7.52e-08)|COAD - Colon adenocarcinoma(152;4.01e-06)|GBM - Glioblastoma multiforme(114;4.36e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00108)|KIRC - Kidney renal clear cell carcinoma(1967;0.00404)|STAD - Stomach adenocarcinoma(196;0.00966)|READ - Rectum adenocarcinoma(331;0.0678)|Lung(427;0.153)		GTTCCCGTCTCTGGGTCATAC	0.567000													74	76					0	0	1	0	0
KMT2D	8085	broad.mit.edu	37	12	49423015	49423015	+	Nonsense_Mutation	SNP	C	C	A			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr12:49423015C>A	ENST00000301067.7	-	44	14079	c.14080G>T	c.(14080-14082)Gag>Tag	p.E4694*		NM_003482.3	NP_003473.3			lysine (K)-specific methyltransferase 2D																		TCATCACTCTCCATCCTGGGG	0.517000													16	22					2.5808e-16	2.88803e-16	1	1	0
TRBV19	28568	broad.mit.edu	37	7	142326760	142326760	+	RNA	SNP	G	G	A			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr7:142326760G>A	ENST00000390393.3	+	0	266																											AGACACCGTGGATGGTGGAAT	0.522000													24	112					0	0	1	0	0
PLEC	5339	broad.mit.edu	37	8	144992609	144992609	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr8:144992609C>T	ENST00000322810.4	-	32	11960	c.11791G>A	c.(11791-11793)Gag>Aag	p.E3931K	PLEC_ENST00000357649.2_Missense_Mutation_p.E3798K|PLEC_ENST00000436759.2_Missense_Mutation_p.E3821K|PLEC_ENST00000398774.2_Missense_Mutation_p.E3762K|PLEC_ENST00000527096.1_Missense_Mutation_p.E3817K|PLEC_ENST00000354958.2_Missense_Mutation_p.E3772K|PLEC_ENST00000356346.3_Missense_Mutation_p.E3780K|PLEC_ENST00000354589.3_Missense_Mutation_p.E3794K|PLEC_ENST00000345136.3_Missense_Mutation_p.E3794K	NM_201380.2	NP_958782.1	Q15149	PLEC_HUMAN	plectin	3931	Globular 2.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle			NS(1)|breast(3)|central_nervous_system(4)|cervix(7)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(8)|lung(57)|ovary(4)|pancreas(2)|prostate(11)|skin(9)|stomach(2)|upper_aerodigestive_tract(10)	137						AGGGCCTCCTCAGTAGGGATC	0.677000													4	4					0	0	1	0	0
DCST1	149095	broad.mit.edu	37	1	155014045	155014045	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr1:155014045C>T	ENST00000295542.1	+	7	800	c.704C>T	c.(703-705)tCg>tTg	p.S235L	DCST1_ENST00000392480.1_Missense_Mutation_p.S235L|DCST1_ENST00000368419.2_Missense_Mutation_p.S235L|DCST1_ENST00000423025.2_Missense_Mutation_p.S210L	NM_152494.3	NP_689707.2	Q5T197	DCST1_HUMAN	DC-STAMP domain containing 1	235						integral to membrane	zinc ion binding			breast(2)|endometrium(4)|kidney(2)|large_intestine(3)|lung(8)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	27	all_epithelial(22;1.43e-30)|all_lung(78;6.64e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		BRCA - Breast invasive adenocarcinoma(34;0.000434)			CTCCACCTGTCGACACAGAAG	0.617000													13	38					0	0	1	0	0
YWHAZ	7534	broad.mit.edu	37	8	101961078	101961078	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr8:101961078C>T	ENST00000395957.2	-	3	381	c.40G>A	c.(40-42)Gag>Aag	p.E14K	YWHAZ_ENST00000353245.3_Missense_Mutation_p.E14K|YWHAZ_ENST00000395948.2_Intron|YWHAZ_ENST00000457309.1_Missense_Mutation_p.E14K|YWHAZ_ENST00000521309.1_Intron|YWHAZ_ENST00000395958.2_Missense_Mutation_p.E14K|YWHAZ_ENST00000395951.3_Missense_Mutation_p.E14K|YWHAZ_ENST00000395956.3_Missense_Mutation_p.E14K|YWHAZ_ENST00000419477.2_Missense_Mutation_p.E14K|YWHAZ_ENST00000395953.2_Missense_Mutation_p.E14K			P63104	1433Z_HUMAN	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide	14					anti-apoptosis|mRNA metabolic process|platelet activation|signal transduction	cytosol|melanosome	transcription factor binding			large_intestine(1)|lung(2)	3	all_cancers(14;7.43e-06)|all_epithelial(15;2.77e-08)|Lung NSC(17;6.08e-05)|all_lung(17;0.000197)		Epithelial(11;2.79e-11)|all cancers(13;5.45e-09)|OV - Ovarian serous cystadenocarcinoma(57;4.75e-05)		Ginkgo biloba(DB01381)	TCAGCCTGCTCGGCCAGTTTG	0.443000													36	74					0	0	1	0	0
NAP1L3	4675	broad.mit.edu	37	X	92927154	92927154	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chrX:92927154C>T	ENST00000373079.3	-	1	1413	c.1150G>A	c.(1150-1152)Gat>Aat	p.D384N	NAP1L3_ENST00000475430.2_Missense_Mutation_p.D377N	NM_004538.5	NP_004529.2	Q99457	NP1L3_HUMAN	nucleosome assembly protein 1-like 3	384					nucleosome assembly	chromatin assembly complex				haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(16)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	34						TCATTGTGATCTGGTTTTGCC	0.403000													3	32					0	0	1	0	0
DNMT1	1786	broad.mit.edu	37	19	10244933	10244933	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr19:10244933G>C	ENST00000340748.4	-	39	5011	c.4776C>G	c.(4774-4776)atC>atG	p.I1592M	DNMT1_ENST00000359526.4_Missense_Mutation_p.I1608M|DNMT1_ENST00000540357.1_Missense_Mutation_p.I1595M			P26358	DNMT1_HUMAN	DNA (cytosine-5-)-methyltransferase 1	1592	Catalytic.|Interaction with the PRC2/EED-EZH2 complex (By similarity).				chromatin modification|maintenance of DNA methylation|negative regulation of histone H3-K9 methylation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of gene expression|positive regulation of histone H3-K4 methylation|transcription, DNA-dependent	nucleus	DNA (cytosine-5-)-methyltransferase activity|DNA binding|transcription factor binding			breast(5)|endometrium(8)|kidney(5)|large_intestine(21)|lung(11)|ovary(2)|pancreas(1)|prostate(10)|skin(5)|stomach(1)|urinary_tract(1)	70			OV - Ovarian serous cystadenocarcinoma(20;1.59e-09)|Epithelial(33;2.86e-06)|all cancers(31;6.68e-06)		Azacitidine(DB00928)|Decitabine(DB01262)|Flucytosine(DB01099)|Ifosfamide(DB01181)|Procainamide(DB01035)	TACAAAGCTTGATCTCCAAGC	0.627000													13	45					0	0	1	0	0
WASF3	10810	broad.mit.edu	37	13	27246115	27246115	+	Silent	SNP	A	A	C			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr13:27246115A>C	ENST00000361042.4	+	6	754	c.529A>C	c.(529-531)Agg>Cgg	p.R177R	WASF3_ENST00000335327.5_Silent_p.R177R|WASF3_ENST00000496788.1_3'UTR			Q9UPY6	WASF3_HUMAN	WAS protein family, member 3	177					actin filament polymerization	cytoplasm|cytoskeleton	actin binding			breast(2)|endometrium(3)|kidney(2)|large_intestine(4)|lung(6)|pancreas(1)|prostate(2)|skin(2)	22	Colorectal(5;0.000247)	Lung SC(185;0.0156)|Breast(139;0.147)		all cancers(112;0.0114)|Epithelial(112;0.046)|OV - Ovarian serous cystadenocarcinoma(117;0.0547)|Lung(94;0.105)|LUSC - Lung squamous cell carcinoma(192;0.155)		GAAAGAGAAAAGGCGTCAAAA	0.343000													5	36					0	0	1	0	0
G2E3	55632	broad.mit.edu	37	14	31071317	31071317	+	Silent	SNP	C	C	T			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr14:31071317C>T	ENST00000206595.6	+	10	1144	c.990C>T	c.(988-990)tcC>tcT	p.S330S	G2E3_ENST00000544007.1_3'UTR|G2E3_ENST00000438909.2_Silent_p.S284S|G2E3_ENST00000553504.1_Silent_p.S360S	NM_017769.3	NP_060239.2	Q7L622	G2E3_HUMAN	G2/M-phase specific E3 ubiquitin protein ligase	330					apoptosis|multicellular organismal development|protein modification process	Golgi apparatus|nucleolus	acid-amino acid ligase activity|protein binding|zinc ion binding			endometrium(2)|kidney(3)|large_intestine(4)|lung(8)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	23						CACCTGGATCCCAGAGTAAAG	0.328000													5	46					0	0	1	0	0
LARP1	23367	broad.mit.edu	37	5	154181879	154181879	+	Missense_Mutation	SNP	A	A	C			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr5:154181879A>C	ENST00000336314.4	+	11	1822	c.1798A>C	c.(1798-1800)Aag>Cag	p.K600Q		NM_015315.3	NP_056130.2	Q6PKG0	LARP1_HUMAN	La ribonucleoprotein domain family, member 1	677							protein binding|RNA binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(10)|lung(9)|ovary(3)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	33	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.147)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)			CGAACTGGCCAAGGTCATTAA	0.557000													6	43					0	0	1	0	0
CABS1	85438	broad.mit.edu	37	4	71200967	71200967	+	Nonsense_Mutation	SNP	A	A	T			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr4:71200967A>T	ENST00000273936.5	+	1	285	c.211A>T	c.(211-213)Aaa>Taa	p.K71*		NM_033122.3	NP_149113.3	Q96KC9	CABS1_HUMAN	calcium-binding protein, spermatid-specific 1							flagellum	calcium ion binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(12)|ovary(4)|pancreas(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	33						ACTGACAGCTAAAAAGGAAAA	0.363000													31	20					0	0	1	0	0
PISD	23761	broad.mit.edu	37	22	32017794	32017794	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr22:32017794G>C	ENST00000382151.2	-	4	716	c.297C>G	c.(295-297)caC>caG	p.H99Q	PISD_ENST00000439502.2_Missense_Mutation_p.H133Q|PISD_ENST00000397500.1_Missense_Mutation_p.H99Q|PISD_ENST00000266095.5_Missense_Mutation_p.H99Q|PISD_ENST00000336566.4_Missense_Mutation_p.H133Q|PISD_ENST00000478893.1_5'UTR			Q9UG56	PISD_HUMAN	phosphatidylserine decarboxylase	133					phospholipid biosynthetic process	mitochondrion	phosphatidylserine decarboxylase activity			central_nervous_system(3)|endometrium(2)|large_intestine(4)|lung(1)|ovary(1)|prostate(1)	12					Phosphatidylserine(DB00144)	TGCGCAGCCAGTGTGGCAGCT	0.622000													32	45					0	0	1	0	0
AQR	9716	broad.mit.edu	37	15	35166897	35166897	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr15:35166897G>C	ENST00000156471.5	-	29	3631	c.3406C>G	c.(3406-3408)Caa>Gaa	p.Q1136E		NM_014691.2	NP_055506.1	O60306	AQR_HUMAN	aquarius intron-binding spliceosomal factor	1136						catalytic step 2 spliceosome	RNA binding			breast(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(10)|lung(18)|ovary(1)|prostate(6)|skin(4)|upper_aerodigestive_tract(2)	57		Lung NSC(122;8.7e-10)|all_lung(180;1.47e-08)		all cancers(64;4.34e-18)|GBM - Glioblastoma multiforme(113;4.59e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0283)		GCTCTCCCTTGAGCATCAAGG	0.408000													39	52					0	0	1	0	0
PRAMEF2	65122	broad.mit.edu	37	1	12921510	12921510	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr1:12921510G>C	ENST00000240189.2	+	4	1388	c.1301G>C	c.(1300-1302)cGg>cCg	p.R434P		NM_023014.1	NP_075390.1	O60811	PRAM2_HUMAN	PRAME family member 2	434								p.R434L(1)		breast(2)|endometrium(1)|kidney(2)|large_intestine(2)|lung(22)|prostate(6)|skin(3)|upper_aerodigestive_tract(4)	42	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.00224)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;2.4e-06)|Kidney(185;4.89e-05)|COAD - Colon adenocarcinoma(227;0.000152)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		ACCCCACTTCGGGCTGAGCTG	0.552000													24	166					0	0	1	0	0
LCE1F	353137	broad.mit.edu	37	1	152749042	152749042	+	Silent	SNP	T	T	G			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr1:152749042T>G	ENST00000334371.2	+	1	195	c.195T>G	c.(193-195)ggT>ggG	p.G65G		NM_178354.2	NP_848131.1	Q5T754	LCE1F_HUMAN	late cornified envelope 1F	65	Poly-Gly.				keratinization			p.G64_G65delGG(1)		kidney(1)|large_intestine(2)|lung(7)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	15	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			CTGGGGGTGGTGGCTGCTGCA	0.677000													8	67					0	0	1	0	0
SLITRK4	139065	broad.mit.edu	37	X	142718607	142718607	+	Silent	SNP	G	G	T	rs41310466	byFrequency	TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chrX:142718607G>T	ENST00000381779.4	-	2	543	c.318C>A	c.(316-318)ctC>ctA	p.L106L	SLITRK4_ENST00000338017.4_Silent_p.L106L|SLITRK4_ENST00000356928.1_Silent_p.L106L	NM_001184749.2|NM_001184750.1|NM_173078.4	NP_001171678.1|NP_001171679.1|NP_775101.1	Q8IW52	SLIK4_HUMAN	SLIT and NTRK-like family, member 4	106						integral to membrane				autonomic_ganglia(1)|breast(1)|endometrium(6)|kidney(2)|large_intestine(11)|lung(27)|ovary(2)|pancreas(2)|prostate(4)|skin(2)|upper_aerodigestive_tract(2)	60	Acute lymphoblastic leukemia(192;6.56e-05)					TTAATGCACTGAGCCCAAGAA	0.423000													10	73					1.08611e-07	1.1708e-07	1	1	0
JMJD4	65094	broad.mit.edu	37	1	227921252	227921252	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr1:227921252C>T	ENST00000366758.3	-	4	822	c.823G>A	c.(823-825)Gac>Aac	p.D275N	SNAP47_ENST00000366760.1_Intron|JMJD4_ENST00000438896.2_Missense_Mutation_p.D275N|JMJD4_ENST00000485807.1_5'UTR|SNAP47_ENST00000480897.1_3'UTR	NM_023007.2	NP_075383.2	Q9H9V9	JMJD4_HUMAN	jumonji domain containing 4	275	JmjC.									endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(2)|ovary(1)|prostate(1)|skin(1)	9		Prostate(94;0.0885)				GAGGTCACGTCGTAGGGCAGG	0.637000													12	29					0	0	1	0	0
SEH1L	81929	broad.mit.edu	37	18	12963256	12963256	+	Missense_Mutation	SNP	A	A	G			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr18:12963256A>G	ENST00000262124.11	+	4	534	c.407A>G	c.(406-408)gAt>gGt	p.D136G	SEH1L_ENST00000399892.2_Missense_Mutation_p.D136G	NM_031216.3	NP_112493.2	Q96EE3	SEH1_HUMAN	SEH1-like (S. cerevisiae)	136					attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation|carbohydrate metabolic process|cell division|glucose transport|mitotic metaphase plate congression|mitotic prometaphase|mRNA transport|nuclear pore organization|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytosol|Nup107-160 complex				central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(5)|pancreas(1)|prostate(1)	11						TGTTCCGCAGATGGTATAGTA	0.423000													7	103					0	0	1	0	0
ZNF667	63934	broad.mit.edu	37	19	56972125	56972125	+	Silent	SNP	C	C	G	rs144865676	byFrequency	TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr19:56972125C>G	ENST00000591790.1	-	3	1521	c.93G>C	c.(91-93)ctG>ctC	p.L31L	ZNF667_ENST00000292069.6_Silent_p.L31L|ZNF667_ENST00000342634.3_Silent_p.L124L|ZNF667_ENST00000504904.3_Silent_p.L31L			Q5HYK9	ZN667_HUMAN	zinc finger protein 667	31	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(11)|lung(18)|pancreas(1)|skin(1)|upper_aerodigestive_tract(3)	38		Colorectal(82;0.000256)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0615)		GAATGGGGCTCAGCCATTCCC	0.468000													20	27					0	0	1	0	0
SCN1A	6323	broad.mit.edu	37	2	166900333	166900333	+	Missense_Mutation	SNP	C	C	T	rs145670933		TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr2:166900333C>T	ENST00000423058.2	-	11	1906	c.1889G>A	c.(1888-1890)cGg>cAg	p.R630Q	AC010127.3_ENST00000595268.1_RNA|SCN1A_ENST00000375405.3_Missense_Mutation_p.R630Q|SCN1A_ENST00000303395.4_Missense_Mutation_p.R630Q|AC010127.3_ENST00000595647.1_RNA|SCN1A_ENST00000409050.1_Missense_Mutation_p.R630Q|AC010127.3_ENST00000599041.1_RNA	NM_001165963.1|NM_001202435.1	NP_001159435.1|NP_001189364.1	P35498	SCN1A_HUMAN	sodium channel, voltage-gated, type I, alpha subunit	630						voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(4)|breast(5)|endometrium(16)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(33)|lung(87)|ovary(7)|pancreas(1)|prostate(9)|skin(23)|upper_aerodigestive_tract(2)|urinary_tract(1)	200					Lamotrigine(DB00555)|Levetiracetam(DB01202)|Phenacemide(DB01121)|Phenytoin(DB00252)|Topiramate(DB00273)|Zonisamide(DB00909)	TGCCAGCATCCGGGATGACCT	0.532000													20	35					0	0	1	0	0
SEC16B	89866	broad.mit.edu	37	1	177906436	177906436	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr1:177906436G>C	ENST00000308284.6	-	19	2505	c.2416C>G	c.(2416-2418)Cta>Gta	p.L806V	RP4-798P15.3_ENST00000354921.3_RNA	NM_033127.2	NP_149118.2	Q96JE7	SC16B_HUMAN	SEC16 homolog B (S. cerevisiae)	806					protein transport|vesicle-mediated transport	endoplasmic reticulum membrane|Golgi membrane				central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(7)|lung(14)|ovary(3)|skin(1)|stomach(1)	35						GTCCCTGGTAGATGGGTCTCA	0.627000													10	21					0	0	1	0	0
RPS20	6224	broad.mit.edu	37	8	56986267	56986267	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr8:56986267C>G	ENST00000519807.1	-	3	289	c.164G>C	c.(163-165)cGa>cCa	p.R55P	RPS20_ENST00000521262.1_Missense_Mutation_p.R55P|RPS20_ENST00000518875.1_Missense_Mutation_p.R55P|RPS20_ENST00000009589.3_Missense_Mutation_p.R55P|RPS20_ENST00000523936.1_Missense_Mutation_p.R55P|RPS20_ENST00000524349.1_5'UTR|RPS20_ENST00000520627.1_5'UTR|RPS20_ENST00000520490.1_Intron|RPS20_ENST00000519606.1_Intron	NM_001146227.1	NP_001139699.1	P60866	RS20_HUMAN	ribosomal protein S20	55					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic small ribosomal subunit	protein binding|RNA binding|structural constituent of ribosome						all_lung(136;0.0548)|Lung NSC(129;0.0718)|all_epithelial(80;0.155)	Epithelial(17;0.00117)|all cancers(17;0.00879)			GGTAGGCATTCGAACTGGTCC	0.418000													58	110					0	0	1	0	0
GDF15	9518	broad.mit.edu	37	19	18499553	18499553	+	Silent	SNP	G	G	C			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr19:18499553G>C	ENST00000252809.3	+	2	767	c.735G>C	c.(733-735)ccG>ccC	p.P245P		NM_004864.2	NP_004855.2	Q99988	GDF15_HUMAN	growth differentiation factor 15	245					cell-cell signaling|transforming growth factor beta receptor signaling pathway	extracellular space	cytokine activity|growth factor activity			kidney(2)|large_intestine(1)|liver(1)|lung(5)|prostate(2)|skin(1)	12						GCGCGTGCCCGAGCCAGTTCC	0.692000											OREG0025363	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	5	20					0	0	1	0	0
DMD	1756	broad.mit.edu	37	X	32328204	32328204	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chrX:32328204G>C	ENST00000357033.4	-	42	6318	c.6112C>G	c.(6112-6114)Ctg>Gtg	p.L2038V	DMD_ENST00000378677.2_Missense_Mutation_p.L2034V	NM_000109.3|NM_004006.2|NM_004011.3|NM_004012.3|NM_004014.2	NP_000100.2|NP_003997|NP_004002.2|NP_004003.1|NP_004005.1	P11532	DMD_HUMAN	dystrophin	2038					muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			NS(2)|breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(17)|liver(1)|lung(25)|ovary(3)|pancreas(3)|prostate(2)|skin(1)|urinary_tract(2)	77		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				TTTACCTTCAGAGACTCCTCT	0.388000													43	13					0	0	1	0	0
PIK3CA	5290	broad.mit.edu	37	3	178917478	178917478	+	Splice_Site	SNP	G	G	A			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr3:178917478G>A	ENST00000263967.3	+	3	510	c.353G>A	c.(352-354)gGt>gAt	p.G118D		NM_006218.2	NP_006209.2	P42336	PK3CA_HUMAN	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha	118					epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.G118D(26)		NS(16)|autonomic_ganglia(4)|biliary_tract(22)|bone(1)|breast(2150)|central_nervous_system(110)|cervix(33)|endometrium(473)|eye(1)|haematopoietic_and_lymphoid_tissue(35)|kidney(14)|large_intestine(1202)|liver(42)|lung(202)|meninges(1)|oesophagus(28)|ovary(235)|pancreas(17)|penis(8)|pituitary(12)|prostate(10)|skin(155)|small_intestine(1)|soft_tissue(18)|stomach(121)|thyroid(80)|upper_aerodigestive_tract(70)|urinary_tract(208)	5269	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			TTTATTAAAGGTTTTGCTATC	0.338000		57	Mis		"""colorectal, gastric, gliobastoma, breast"""					HNSCC(19;0.045)|TSP Lung(28;0.18)			16	33					0	0	1	0	0
TMEM87A	25963	broad.mit.edu	37	15	42556389	42556389	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr15:42556389C>G	ENST00000389834.4	-	4	568	c.304G>C	c.(304-306)Gag>Cag	p.E102Q	TMEM87A_ENST00000568432.1_5'UTR|TMEM87A_ENST00000307216.6_Missense_Mutation_p.E102Q|TMEM87A_ENST00000448392.1_Missense_Mutation_p.E41Q	NM_015497.3	NP_056312.2	Q8NBN3	TM87A_HUMAN	transmembrane protein 87A	102						integral to membrane				breast(1)|endometrium(4)|kidney(4)|large_intestine(1)|lung(9)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	24		all_cancers(109;4.28e-16)|all_epithelial(112;1.04e-14)|Lung NSC(122;5.01e-09)|all_lung(180;2.24e-08)|Melanoma(134;0.0574)|Colorectal(260;0.152)		GBM - Glioblastoma multiforme(94;1.03e-06)		AAATACAACTCTACTTCTTCT	0.358000													15	35					0	0	1	0	0
USP37	57695	broad.mit.edu	37	2	219339413	219339413	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr2:219339413C>T	ENST00000258399.3	-	20	2651	c.2239G>A	c.(2239-2241)Gaa>Aaa	p.E747K	USP37_ENST00000415516.1_Missense_Mutation_p.E653K|USP37_ENST00000454775.1_Missense_Mutation_p.E747K|USP37_ENST00000418019.1_Missense_Mutation_p.E747K	NM_020935.2	NP_065986	Q86T82	UBP37_HUMAN	ubiquitin specific peptidase 37	747					ubiquitin-dependent protein catabolic process	nucleus	cysteine-type peptidase activity|ubiquitin thiolesterase activity			NS(2)|breast(3)|cervix(1)|endometrium(6)|kidney(4)|large_intestine(1)|lung(7)|ovary(2)|prostate(3)|skin(5)|stomach(1)	35		Renal(207;0.0915)		Epithelial(149;1.08e-06)|all cancers(144;0.000197)|LUSC - Lung squamous cell carcinoma(224;0.00375)|Lung(261;0.00487)		TCTGGCATTTCTTGAATATCA	0.403000													35	103					0	0	1	0	0
TGFBR2	7048	broad.mit.edu	37	3	30713405	30713405	+	Missense_Mutation	SNP	A	A	T			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr3:30713405A>T	ENST00000295754.5	+	4	1112	c.730A>T	c.(730-732)Att>Ttt	p.I244F	TGFBR2_ENST00000359013.4_Missense_Mutation_p.I269F	NM_003242.5	NP_003233.4	P37173	TGFR2_HUMAN	transforming growth factor, beta receptor II (70/80kDa)	244	Protein kinase.				activation of protein kinase activity|brain development|embryonic cranial skeleton morphogenesis|embryonic hemopoiesis|heart development|myeloid dendritic cell differentiation|palate development|pathway-restricted SMAD protein phosphorylation|patterning of blood vessels|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of B cell tolerance induction|positive regulation of mesenchymal cell proliferation|positive regulation of NK T cell differentiation|positive regulation of reactive oxygen species metabolic process|positive regulation of T cell tolerance induction|positive regulation of tolerance induction to self antigen|response to cholesterol|response to drug|transforming growth factor beta receptor signaling pathway|vasculogenesis	caveola|external side of plasma membrane	ATP binding|glycosaminoglycan binding|metal ion binding|protein binding|receptor signaling protein serine/threonine kinase activity|SMAD binding|transforming growth factor beta binding|transforming growth factor beta receptor activity, type II|type I transforming growth factor beta receptor binding|type III transforming growth factor beta receptor binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(15)|lung(10)|ovary(3)|pancreas(12)|skin(1)|stomach(5)|upper_aerodigestive_tract(2)	53						GCTGCTGCCCATTGAGCTGGA	0.537000													21	31					0	0	1	0	0
GTF2I	2969	broad.mit.edu	37	7	74120733	74120733	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr7:74120733C>G	ENST00000324896.4	+	8	1043	c.654C>G	c.(652-654)atC>atG	p.I218M	GTF2I_ENST00000416070.1_Missense_Mutation_p.I218M|GTF2I_ENST00000346152.4_Missense_Mutation_p.I218M|GTF2I_ENST00000443166.1_Missense_Mutation_p.I218M|AC083884.8_ENST00000434256.1_RNA|GTF2I_ENST00000353920.4_Missense_Mutation_p.I218M|AC083884.8_ENST00000594967.1_RNA|AC083884.8_ENST00000450426.2_RNA	NM_032999.2	NP_127492.1	P78347	GTF2I_HUMAN	general transcription factor IIi	218					negative regulation of angiogenesis|signal transduction|transcription initiation from RNA polymerase II promoter	cytoplasm|nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			NS(1)|endometrium(7)|kidney(1)|large_intestine(1)|lung(5)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	19						GTGGCCCCATCAAAGTGAAAA	0.423000													36	75					0	0	1	0	0
SLC2A2	6514	broad.mit.edu	37	3	170720436	170720436	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr3:170720436C>T	ENST00000314251.3	-	8	1076	c.997G>A	c.(997-999)Gct>Act	p.A333T	SLC2A2_ENST00000382808.4_Missense_Mutation_p.A214T	NM_000340.1	NP_000331.1	P11168	GTR2_HUMAN	solute carrier family 2 (facilitated glucose transporter), member 2	333					carbohydrate metabolic process|cellular lipid metabolic process|endocrine pancreas development|energy reserve metabolic process|regulation of insulin secretion	integral to plasma membrane|membrane fraction	D-glucose transmembrane transporter activity			central_nervous_system(1)|endometrium(2)|large_intestine(9)|lung(9)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	24	all_cancers(22;1.41e-19)|all_lung(20;1.59e-15)|Lung NSC(18;7.08e-15)|Ovarian(172;0.00197)|Breast(254;0.122)		LUSC - Lung squamous cell carcinoma(14;1.1e-14)|Lung(28;2.99e-14)			CTGATACCAGCCGTCTGAAAA	0.388000													36	52					0	0	1	0	0
KMT2D	8085	broad.mit.edu	37	12	49421925	49421925	+	Splice_Site	SNP	C	C	T			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr12:49421925C>T	ENST00000301067.7	-	46	14382		c.e46-1			NM_003482.3	NP_003473.3			lysine (K)-specific methyltransferase 2D																		CATTCAGGTTCTGCCAGGGCC	0.592000													12	28					0	0	1	0	0
SPOP	8405	broad.mit.edu	37	17	47696435	47696435	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr17:47696435C>G	ENST00000393331.3	-	7	858	c.388G>C	c.(388-390)Gac>Cac	p.D130H	SPOP_ENST00000347630.2_Missense_Mutation_p.D130H|SPOP_ENST00000503676.1_Missense_Mutation_p.D130H|SPOP_ENST00000504102.1_Missense_Mutation_p.D130H|SPOP_ENST00000393328.2_Missense_Mutation_p.D130H	NM_001007226.1|NM_001007227.1	NP_001007227.1|NP_001007228.1	O43791	SPOP_HUMAN	speckle-type POZ protein	130	MATH.|Required for nuclear localization.				mRNA processing	nucleus	protein binding			endometrium(18)|kidney(1)|large_intestine(3)|liver(1)|lung(4)|ovary(3)|prostate(33)	63						AATCCCCAGTCTTTGCCTTGC	0.458000										Prostate(2;0.17)			25	85					0	0	1	0	0
PEX19	5824	broad.mit.edu	37	1	160249629	160249629	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr1:160249629C>T	ENST00000368072.5	-	7	799	c.778G>A	c.(778-780)Gat>Aat	p.D260N	PEX19_ENST00000440949.3_Missense_Mutation_p.D170N|PEX19_ENST00000532508.1_5'UTR|DCAF8_ENST00000608310.1_Missense_Mutation_p.D113N|DCAF8_ENST00000556710.1_Missense_Mutation_p.D113N	NM_001193644.1|NM_002857.3	NP_001180573.1|NP_002848.1			peroxisomal biogenesis factor 19											cervix(1)|endometrium(2)|large_intestine(2)|lung(4)|prostate(2)	11	all_cancers(52;1.27e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			TGGCCTAAATCTTGTAGCTAG	0.368000													20	32					0	0	1	0	0
MKS1	54903	broad.mit.edu	37	17	56290372	56290372	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr17:56290372C>T	ENST00000393119.2	-	8	903	c.829G>A	c.(829-831)Gag>Aag	p.E277K	MKS1_ENST00000537529.2_Missense_Mutation_p.E267K|MKS1_ENST00000337050.7_Missense_Mutation_p.E277K|MKS1_ENST00000313863.6_Missense_Mutation_p.E277K|MKS1_ENST00000546108.1_Missense_Mutation_p.E74K	NM_017777.3	NP_060247.2	Q9NXB0	MKS1_HUMAN	Meckel syndrome, type 1	277					cilium assembly	centrosome|cilium|microtubule basal body	protein binding			endometrium(5)|kidney(3)|large_intestine(3)|lung(10)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	26						TCCCGCTCCTCCTCCTCCGGC	0.532000													35	51					0	0	1	0	0
MYPOP	339344	broad.mit.edu	37	19	46393971	46393971	+	Silent	SNP	T	T	G			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr19:46393971T>G	ENST00000322217.5	-	3	1196	c.1110A>C	c.(1108-1110)ccA>ccC	p.P370P		NM_001012643.2	NP_001012661.1	Q86VE0	MYPOP_HUMAN	Myb-related transcription factor, partner of profilin	370	Pro-rich.					nucleus	DNA binding	p.A371fs*>30(1)		large_intestine(2)|lung(1)|skin(1)	4						GGAGCGGGGCTGGGGGGGGCC	0.657000													5	12					0	0	1	0	0
DMRT1	1761	broad.mit.edu	37	9	894058	894058	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr9:894058C>T	ENST00000382276.3	+	3	834	c.685C>T	c.(685-687)Ccg>Tcg	p.P229S	DMRT1_ENST00000569227.1_Missense_Mutation_p.P71S	NM_021951.2	NP_068770.2	Q9Y5R6	DMRT1_HUMAN	doublesex and mab-3 related transcription factor 1	229					cell differentiation|male gonad development|sex determination	nucleus	DNA binding|metal ion binding|sequence-specific DNA binding transcription factor activity			large_intestine(2)|lung(10)|ovary(1)	13		all_lung(10;2.66e-10)|Lung NSC(10;2.82e-10)|Breast(48;0.232)		Lung(218;0.037)		ATACAACTGCCCGCAGTACTC	0.557000											OREG0019071	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	52	23					0	0	1	0	0
ATP8B3	148229	broad.mit.edu	37	19	1800145	1800145	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr19:1800145G>T	ENST00000539485.1	-	14	1586	c.1353C>A	c.(1351-1353)ttC>ttA	p.F451L	ATP8B3_ENST00000310127.6_Missense_Mutation_p.F451L|ATP8B3_ENST00000525591.1_Missense_Mutation_p.F404L|ATP8B3_ENST00000526092.2_Missense_Mutation_p.F398L			O60423	AT8B3_HUMAN	ATPase, aminophospholipid transporter, class I, type 8B, member 3	451					ATP biosynthetic process		ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			central_nervous_system(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(9)|ovary(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	23		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CCAGGTAGATGAACTCGGACC	0.652000													4	6					1	1	1	1	0
VCAM1	7412	broad.mit.edu	37	1	101190416	101190416	+	Missense_Mutation	SNP	A	A	T			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr1:101190416A>T	ENST00000294728.2	+	4	999	c.898A>T	c.(898-900)Aac>Tac	p.N300Y	VCAM1_ENST00000370119.4_Missense_Mutation_p.N238Y|VCAM1_ENST00000347652.2_Missense_Mutation_p.N300Y|VCAM1_ENST00000370115.1_Missense_Mutation_p.N300Y	NM_001078.3	NP_001069.1	P19320	VCAM1_HUMAN	vascular cell adhesion molecule 1	300	Ig-like C2-type 3.				heterophilic cell-cell adhesion|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|leukocyte tethering or rolling|membrane to membrane docking|positive regulation of T cell proliferation|regulation of immune response	alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex|apical part of cell|external side of plasma membrane|extracellular space|filopodium|integral to membrane|microvillus|podosome	cell adhesion molecule binding|integrin binding			central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|liver(1)|lung(27)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	56		all_epithelial(167;3.83e-06)|all_lung(203;0.000485)|Lung NSC(277;0.0011)		Epithelial(280;0.0227)|all cancers(265;0.0276)|COAD - Colon adenocarcinoma(174;0.149)|Colorectal(144;0.169)|Lung(183;0.196)	Carvedilol(DB01136)	GATTGGGAAAAACAGAAAAGA	0.378000													21	24					0	0	1	0	0
ZNF716	441234	broad.mit.edu	37	7	57529009	57529009	+	Nonsense_Mutation	SNP	C	C	G			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr7:57529009C>G	ENST00000420713.1	+	4	954	c.842C>G	c.(841-843)tCa>tGa	p.S281*		NM_001159279.1	NP_001152751.1			zinc finger protein 716											breast(1)|kidney(1)|lung(20)|ovary(2)	24						TTTAGCCGCTCAACACTTACT	0.413000													23	30					0	0	1	0	0
BNC2	54796	broad.mit.edu	37	9	16419503	16419503	+	Silent	SNP	C	C	T			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr9:16419503C>T	ENST00000380672.4	-	7	2841	c.2784G>A	c.(2782-2784)ggG>ggA	p.G928G	BNC2_ENST00000545497.1_Silent_p.G833G|BNC2_ENST00000380667.2_Silent_p.G861G	NM_017637.5	NP_060107.3	Q6ZN30	BNC2_HUMAN	basonuclin 2	928					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	zinc ion binding			NS(2)|breast(3)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(16)|liver(1)|lung(22)|ovary(2)|prostate(1)|skin(1)|urinary_tract(2)	60				GBM - Glioblastoma multiforme(50;9.01e-08)		TGACATCGAGCCCCATGGGGT	0.577000													33	73					0	0	1	0	0
LATS1	9113	broad.mit.edu	37	6	150001083	150001083	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr6:150001083G>A	ENST00000543571.1	-	5	3068	c.2521C>T	c.(2521-2523)Cat>Tat	p.H841Y	LATS1_ENST00000253339.5_Missense_Mutation_p.H841Y|LATS1_ENST00000542747.1_5'UTR	NM_004690.3	NP_004681.1	O95835	LATS1_HUMAN	large tumor suppressor kinase 1	841	Protein kinase.				cell division|cytoplasmic sequestering of protein|G2/M transition of mitotic cell cycle|hippo signaling cascade|hormone-mediated signaling pathway|mitosis|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cyclin-dependent protein kinase activity|positive regulation of peptidyl-serine phosphorylation|regulation of actin filament polymerization|sister chromatid segregation	microtubule organizing center|spindle pole	ATP binding|magnesium ion binding|protein kinase binding|protein serine/threonine kinase activity			central_nervous_system(1)|lung(5)	6		Ovarian(120;0.0164)		OV - Ovarian serous cystadenocarcinoma(155;6.93e-13)|GBM - Glioblastoma multiforme(68;0.116)		AATTTAATATGACCATCACGA	0.338000													23	33					0	0	1	0	0
KIAA1644	85352	broad.mit.edu	37	22	44692665	44692665	+	Silent	SNP	G	G	A			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr22:44692665G>A	ENST00000381176.4	-	3	300	c.168C>T	c.(166-168)ttC>ttT	p.F56F		NM_001099294.1	NP_001092764.1	Q3SXP7	K1644_HUMAN	KIAA1644	56						integral to membrane				breast(1)|endometrium(1)|large_intestine(2)|lung(3)|ovary(1)|skin(1)	9		all_neural(38;0.0762)|Ovarian(80;0.105)|Glioma(61;0.222)				AACAGAGGATGAAGGTCTTGT	0.557000													83	113					0	0	1	0	0
NPFFR2	10886	broad.mit.edu	37	4	73012898	73012898	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr4:73012898C>A	ENST00000308744.6	+	4	1036	c.938C>A	c.(937-939)cCa>cAa	p.P313Q	NPFFR2_ENST00000358749.3_Missense_Mutation_p.P211Q|NPFFR2_ENST00000395999.1_Missense_Mutation_p.P214Q|NPFFR2_ENST00000506359.1_3'UTR|NPFFR2_ENST00000344413.5_3'UTR	NM_004885.2	NP_004876.2	Q9Y5X5	NPFF2_HUMAN	neuropeptide FF receptor 2	313					detection of abiotic stimulus	actin cytoskeleton|integral to plasma membrane	neuropeptide receptor activity			NS(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(24)|ovary(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	43			Lung(101;0.0935)|LUSC - Lung squamous cell carcinoma(112;0.138)			GAAGACTGGCCAAATCAGGAA	0.453000													25	14					5.45024e-15	6.04154e-15	1	1	0
KMT2D	8085	broad.mit.edu	37	12	49421666	49421666	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr12:49421666C>G	ENST00000301067.7	-	47	14562	c.14563G>C	c.(14563-14565)Gat>Cat	p.D4855H		NM_003482.3	NP_003473.3			lysine (K)-specific methyltransferase 2D																		TTCAGCCAATCAGGGCCAGTG	0.537000													8	10					0	0	1	0	0
PPP1R3A	5506	broad.mit.edu	37	7	113522169	113522169	+	Silent	SNP	C	C	T			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr7:113522169C>T	ENST00000284601.3	-	3	959	c.891G>A	c.(889-891)ttG>ttA	p.L297L		NM_002711.3	NP_002702.2	Q16821	PPR3A_HUMAN	protein phosphatase 1, regulatory subunit 3A	297					glycogen metabolic process	integral to membrane				NS(2)|breast(8)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(14)|liver(1)|lung(43)|ovary(10)|pancreas(7)|prostate(3)|skin(15)|stomach(1)|upper_aerodigestive_tract(2)	121						TACTGGCTTCCAAATCTTCCT	0.333000													5	82					0	0	1	0	0
MARK2	2011	broad.mit.edu	37	11	63662744	63662744	+	Silent	SNP	C	C	G			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr11:63662744C>G	ENST00000402010.2	+	2	747	c.168C>G	c.(166-168)ctC>ctG	p.L56L	MARK2_ENST00000377810.3_Silent_p.L23L|MARK2_ENST00000413835.2_Silent_p.L56L|MARK2_ENST00000350490.7_Silent_p.L56L|MARK2_ENST00000508192.1_Silent_p.L56L|MARK2_ENST00000361128.5_Silent_p.L56L|MARK2_ENST00000408948.3_Silent_p.L23L|MARK2_ENST00000509502.2_Silent_p.L23L|MARK2_ENST00000502399.3_Silent_p.L56L|MARK2_ENST00000315032.8_Silent_p.L56L|MARK2_ENST00000377809.4_Silent_p.L56L|MARK2_ENST00000425897.2_Silent_p.L23L|MARK2_ENST00000513765.2_Silent_p.L23L	NM_001039469.2	NP_001034558.2	Q7KZI7	MARK2_HUMAN	MAP/microtubule affinity-regulating kinase 2	56	Protein kinase.				cell differentiation|establishment or maintenance of epithelial cell apical/basal polarity|intracellular protein kinase cascade|multicellular organismal development|response to oxidative stress	plasma membrane	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(13)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	33						ACCGGCTCCTCAAGACCATTG	0.562000													37	30					0	0	1	0	0
ESPL1	9700	broad.mit.edu	37	12	53682466	53682466	+	Nonsense_Mutation	SNP	C	C	G			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr12:53682466C>G	ENST00000257934.4	+	20	4782	c.4691C>G	c.(4690-4692)tCa>tGa	p.S1564*	ESPL1_ENST00000552462.1_Nonsense_Mutation_p.S1564*	NM_012291.4	NP_036423.4	Q14674	ESPL1_HUMAN	extra spindle pole bodies homolog 1 (S. cerevisiae)	1564					apoptosis|cytokinesis|establishment of mitotic spindle localization|mitotic sister chromatid segregation|negative regulation of sister chromatid cohesion|positive regulation of mitotic metaphase/anaphase transition|proteolysis	centrosome|nucleus	cysteine-type peptidase activity|protein binding			breast(1)|central_nervous_system(1)|endometrium(7)|kidney(10)|large_intestine(12)|lung(21)|ovary(2)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(8)	70						CGGCTCCCCTCAGCCCCCGTA	0.607000													11	49					0	0	1	0	0
PADI6	353238	broad.mit.edu	37	1	17723476	17723477	+	RNA	INS	-	-	CA	rs67024576	by1000genomes	TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr1:17723476_17723477insCA	ENST00000434762.2	+	0	1669							Q6TGC4	PADI6_HUMAN	peptidyl arginine deiminase, type VI						peptidyl-citrulline biosynthetic process from peptidyl-arginine	cytoplasm|nucleus	calcium ion binding|protein-arginine deiminase activity			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(9)|lung(9)|ovary(2)	29		Colorectal(325;3.46e-05)|Breast(348;0.000162)|all_lung(284;0.000337)|Lung NSC(340;0.000419)|Renal(390;0.000518)|Ovarian(437;0.00409)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00488)|BRCA - Breast invasive adenocarcinoma(304;7.59e-06)|COAD - Colon adenocarcinoma(227;1.18e-05)|Kidney(64;0.000186)|KIRC - Kidney renal clear cell carcinoma(64;0.00272)|STAD - Stomach adenocarcinoma(196;0.0134)|READ - Rectum adenocarcinoma(331;0.0655)|Lung(427;0.189)	L-Citrulline(DB00155)	AGGAATGCACCCAGGTGGCTGG	0.629													7	2	---	---	---	---					
NPAS2	4862	broad.mit.edu	37	2	101521216	101521220	+	Frame_Shift_Del	DEL	AATGG	AATGG	-			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr2:101521216_101521220delAATGG	ENST00000542504.1	+	2	197_201	c.195_199delAATGG	c.(193-201)ctaatggatfs	p.MD66fs	NPAS2_ENST00000335681.5_Start_Codon_Del			Q99743	NPAS2_HUMAN	neuronal PAS domain protein 2	1					central nervous system development|positive regulation of transcription from RNA polymerase II promoter|rhythmic process	transcription factor complex	DNA binding|Hsp90 protein binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			cervix(1)|endometrium(3)|large_intestine(7)|lung(9)|ovary(3)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29						TAGAAAATCTAATGGATGAAGATGA	0.424													7	14	---	---	---	---					
ZEB2	9839	broad.mit.edu	37	2	145187411	145187412	+	Frame_Shift_Ins	INS	-	-	T			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr2:145187411_145187412insT	ENST00000558170.2	-	3	1439_1440	c.255_256insA	c.(253-258)gaagatfs	p.D86fs	ZEB2_ENST00000303660.4_Frame_Shift_Ins_p.D86fs|ZEB2_ENST00000409487.3_Frame_Shift_Ins_p.D86fs|ZEB2_ENST00000539609.3_Frame_Shift_Ins_p.D86fs	NM_014795.3	NP_055610.1	O60315	ZEB2_HUMAN	zinc finger E-box binding homeobox 2	86						cytoplasm|nucleolus	phosphatase regulator activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|SMAD binding|zinc ion binding			breast(3)|central_nervous_system(1)|cervix(2)|endometrium(7)|kidney(6)|large_intestine(23)|lung(45)|ovary(5)|pancreas(2)|prostate(6)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	107				BRCA - Breast invasive adenocarcinoma(221;0.112)		CTTATTTCATCTTCCTCTTCCT	0.530													29	32	---	---	---	---					
STAG3L4	64940	broad.mit.edu	37	7	66772495	66772495	+	RNA	DEL	T	T	-			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr7:66772495delT	ENST00000416602.2	+	0	362					NR_040586.1		Q8TBR4	STG34_HUMAN												endometrium(2)|lung(5)	7		Lung NSC(55;0.0839)|all_lung(88;0.181)				GCTTGATTCCTTTTTTTTTTT	0.423													2	4	---	---	---	---					
SCAI	286205	broad.mit.edu	37	9	127789123	127789124	+	Frame_Shift_Del	DEL	TC	TC	-			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr9:127789123_127789124delTC	ENST00000336505.6	-	6	537_538	c.479_480delGA	c.(478-480)agafs	p.R160fs	SCAI_ENST00000373549.4_Frame_Shift_Del_p.R183fs	NM_001144877.2	NP_001138349.1	Q8N9R8	SCAI_HUMAN	suppressor of cancer cell invasion		Necessary to inhibit MKL1-induced SRF transcriptional activity (By similarity).|Required for interaction with MKL1 (By similarity).				negative regulation of cell migration|negative regulation of Rho protein signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|integral to membrane|nucleus	protein binding|transcription corepressor activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(7)|large_intestine(4)|lung(8)|ovary(2)|pancreas(1)|prostate(5)|stomach(1)|urinary_tract(1)	35						AATAATATGATCTCTGTCTGAT	0.327													18	66	---	---	---	---					
TPM4	7171	broad.mit.edu	37	19	16192768	16192770	+	In_Frame_Del	DEL	GAG	GAG	-	rs114629262	byFrequency	TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr19:16192768_16192770delGAG	ENST00000300933.4	+	2	438_440	c.178_180delGAG	c.(178-180)gagdel	p.E62del	TPM4_ENST00000344824.6_In_Frame_Del_p.E98del|TPM4_ENST00000538887.1_In_Frame_Del_p.E98del	NM_003290.2	NP_003281.1	P67936	TPM4_HUMAN	tropomyosin 4	62					cellular component movement|muscle filament sliding|response to oxidative stress	cytosol|muscle thin filament tropomyosin|stress fiber	actin binding|calcium ion binding|structural constituent of muscle		TPM4/ALK(12)	breast(1)|large_intestine(3)	4						CCAGCTCGTTGAGGAGGAGTTGG	0.596			T	ALK	ALCL								17	39	---	---	---	---					
ZNF180	7733	broad.mit.edu	37	19	44980777	44980777	+	Frame_Shift_Del	DEL	T	T	-			TCGA-ZF-AA4N-01A-11D-A38G-08	TCGA-ZF-AA4N-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a499fb-4149-4741-a598-6be9709674cf	f0bc45ae-3001-41f1-ba88-1ff8e3b1c449	g.chr19:44980777delT	ENST00000221327.4	-	5	2202	c.1921delA	c.(1921-1923)acafs	p.T641fs	ZNF180_ENST00000391956.4_Frame_Shift_Del_p.T616fs|ZNF180_ENST00000592529.1_Frame_Shift_Del_p.T614fs	NM_013256.3	NP_037388.2	Q9UJW8	ZN180_HUMAN	zinc finger protein 180	641					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|endometrium(3)|kidney(5)|large_intestine(14)|lung(6)|ovary(2)|urinary_tract(1)	33		Prostate(69;0.0435)				AAGCTAAATGTTTTTCCACAC	0.388													18	120	---	---	---	---