Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
DNM1	1759	broad.mit.edu	37	9	130984852	130984852	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA56-01A-31D-A391-08	TCGA-ZF-AA56-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85d9812c-68d6-4bdf-8674-bccf1eb0c8a8	26bda3c7-7369-4096-8905-08248b5bb9f1	g.chr9:130984852C>T	ENST00000341179.7	+	8	1197	c.1105C>T	c.(1105-1107)Cgc>Tgc	p.R369C	DNM1_ENST00000486160.1_Missense_Mutation_p.R369C|DNM1_ENST00000372923.3_Missense_Mutation_p.R369C|DNM1_ENST00000475805.1_Missense_Mutation_p.R369C|DNM1_ENST00000393594.3_Missense_Mutation_p.R369C	NM_001005336.1	NP_001005336.1	Q05193	DYN1_HUMAN	dynamin 1	369					receptor-mediated endocytosis	microtubule	GTP binding|GTPase activity			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(15)|lung(6)|ovary(2)|urinary_tract(2)	32						CTTCCACGAGCGCTTCCCTTT	0.582000													5	63					0	0	1	0	0
KCTD21	283219	broad.mit.edu	37	11	77884925	77884925	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA56-01A-31D-A391-08	TCGA-ZF-AA56-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85d9812c-68d6-4bdf-8674-bccf1eb0c8a8	26bda3c7-7369-4096-8905-08248b5bb9f1	g.chr11:77884925C>T	ENST00000340067.3	-	2	954	c.676G>A	c.(676-678)Gag>Aag	p.E226K	KCTD21-AS1_ENST00000523626.2_RNA|KCTD21-AS1_ENST00000528468.1_RNA|KCTD21-AS1_ENST00000600795.1_RNA	NM_001029859.1	NP_001025030.1	Q4G0X4	KCD21_HUMAN	potassium channel tetramerization domain containing 21	226						voltage-gated potassium channel complex	voltage-gated potassium channel activity			breast(1)|endometrium(1)|large_intestine(4)|lung(2)|pancreas(1)|prostate(2)	11	all_cancers(14;3.77e-18)|all_epithelial(13;6.16e-21)|Breast(9;5.6e-16)|Ovarian(111;0.152)		OV - Ovarian serous cystadenocarcinoma(8;1.46e-24)			TTCAGTACCTCTTCCACGAAG	0.498000													41	137					0	0	1	0	0
CASP5	838	broad.mit.edu	37	11	104877943	104877943	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA56-01A-31D-A391-08	TCGA-ZF-AA56-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85d9812c-68d6-4bdf-8674-bccf1eb0c8a8	26bda3c7-7369-4096-8905-08248b5bb9f1	g.chr11:104877943C>G	ENST00000393141.2	-	3	370	c.339G>C	c.(337-339)aaG>aaC	p.K113N	CASP5_ENST00000393139.2_Missense_Mutation_p.K67N|CASP5_ENST00000531367.1_Intron|CASP5_ENST00000526056.1_Missense_Mutation_p.K113N|CASP5_ENST00000260315.3_Missense_Mutation_p.K100N|CASP5_ENST00000418434.1_Intron|CASP5_ENST00000444749.2_Missense_Mutation_p.K42N	NM_001136112.1|NM_004347.3	NP_001129584.1|NP_004338.3	P51878	CASP5_HUMAN	caspase 5, apoptosis-related cysteine peptidase	100	CARD.				apoptosis|cellular response to mechanical stimulus|proteolysis|regulation of apoptosis	intracellular	cysteine-type endopeptidase activity|protein binding			NS(1)|breast(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(5)|lung(15)|ovary(3)|skin(1)|urinary_tract(1)	35		Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0017)|Melanoma(852;0.0047)		BRCA - Breast invasive adenocarcinoma(274;0.000943)|Epithelial(105;0.0104)|all cancers(92;0.042)		AATATTTTTTCTTTTCCTCTT	0.368000													20	80					0	0	1	0	0
PLAT	5327	broad.mit.edu	37	8	42045016	42045016	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA56-01A-31D-A391-08	TCGA-ZF-AA56-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85d9812c-68d6-4bdf-8674-bccf1eb0c8a8	26bda3c7-7369-4096-8905-08248b5bb9f1	g.chr8:42045016C>T	ENST00000220809.4	-	6	695	c.439G>A	c.(439-441)Gag>Aag	p.E147K	PLAT_ENST00000519510.1_Intron|PLAT_ENST00000429089.2_Missense_Mutation_p.E147K|PLAT_ENST00000429710.2_Intron|PLAT_ENST00000352041.3_Missense_Mutation_p.E101K|PLAT_ENST00000524009.1_Intron|PLAT_ENST00000270189.6_Missense_Mutation_p.E147K	NM_000930.3	NP_000921.1	P00750	TPA_HUMAN	plasminogen activator, tissue	147	Kringle 1.				blood coagulation|fibrinolysis|negative regulation of proteolysis|protein modification process|proteolysis	cell surface|cytoplasm|extracellular space	protein binding|serine-type endopeptidase activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(10)|skin(1)|soft_tissue(1)|urinary_tract(1)	27	all_cancers(6;3.84e-26)|all_epithelial(6;9.61e-28)|all_lung(13;7.2e-13)|Lung NSC(13;1.18e-11)|Ovarian(28;0.00438)|Prostate(17;0.0119)|Colorectal(14;0.0468)|Lung SC(25;0.211)	all_lung(54;0.000378)|Lung NSC(58;0.00145)|Hepatocellular(245;0.0524)|Renal(179;0.0822)|Esophageal squamous(32;0.0954)	BRCA - Breast invasive adenocarcinoma(8;5.23e-10)|OV - Ovarian serous cystadenocarcinoma(14;0.00135)|Colorectal(10;0.00165)|Lung(22;0.00467)|COAD - Colon adenocarcinoma(11;0.0171)|LUSC - Lung squamous cell carcinoma(45;0.024)		Alteplase(DB00009)|Aminocaproic Acid(DB00513)|Anistreplase(DB00029)|Iloprost(DB01088)|Reteplase(DB00015)|Tenecteplase(DB00031)|Tranexamic Acid(DB00302)|Urokinase(DB00013)	TTGGTGCACTCGGCGCCACTC	0.652000													7	35					0	0	1	0	0
STK11IP	114790	broad.mit.edu	37	2	220472880	220472880	+	Missense_Mutation	SNP	T	T	G			TCGA-ZF-AA56-01A-31D-A391-08	TCGA-ZF-AA56-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85d9812c-68d6-4bdf-8674-bccf1eb0c8a8	26bda3c7-7369-4096-8905-08248b5bb9f1	g.chr2:220472880T>G	ENST00000456909.1	+	14	1421	c.1331T>G	c.(1330-1332)cTg>cGg	p.L444R	STK11IP_ENST00000295641.10_Missense_Mutation_p.L455R			Q8N1F8	S11IP_HUMAN	serine/threonine kinase 11 interacting protein	455					protein localization	cytoplasm	protein kinase binding			breast(2)|endometrium(5)|kidney(1)|large_intestine(2)|lung(10)|ovary(1)|prostate(1)|urinary_tract(1)	23		Renal(207;0.0183)		Epithelial(149;2.69e-07)|all cancers(144;5.91e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GGAAACCCTCTGCCGGCCACC	0.667000													11	41					0	0	1	0	0
PLEC	5339	broad.mit.edu	37	8	145003389	145003389	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA56-01A-31D-A391-08	TCGA-ZF-AA56-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85d9812c-68d6-4bdf-8674-bccf1eb0c8a8	26bda3c7-7369-4096-8905-08248b5bb9f1	g.chr8:145003389C>T	ENST00000322810.4	-	25	3722	c.3553G>A	c.(3553-3555)Gag>Aag	p.E1185K	PLEC_ENST00000356346.3_Missense_Mutation_p.E1034K|PLEC_ENST00000357649.2_Missense_Mutation_p.E1052K|PLEC_ENST00000354958.2_Missense_Mutation_p.E1026K|PLEC_ENST00000436759.2_Missense_Mutation_p.E1075K|PLEC_ENST00000345136.3_Missense_Mutation_p.E1048K|PLEC_ENST00000354589.3_Missense_Mutation_p.E1048K|PLEC_ENST00000527096.1_Missense_Mutation_p.E1071K|PLEC_ENST00000398774.2_Missense_Mutation_p.E1016K	NM_201380.2	NP_958782.1	Q15149	PLEC_HUMAN	plectin	1185	Globular 1.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle			NS(1)|breast(3)|central_nervous_system(4)|cervix(7)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(8)|lung(57)|ovary(4)|pancreas(2)|prostate(11)|skin(9)|stomach(2)|upper_aerodigestive_tract(10)	137						AAGACCTTCTCGGCCTCGGCA	0.687000													3	10					0	0	1	0	0
CD274	29126	broad.mit.edu	37	9	5457197	5457197	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-AA56-01A-31D-A391-08	TCGA-ZF-AA56-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85d9812c-68d6-4bdf-8674-bccf1eb0c8a8	26bda3c7-7369-4096-8905-08248b5bb9f1	g.chr9:5457197G>T	ENST00000381577.3	+	3	257	c.171G>T	c.(169-171)tgG>tgT	p.W57C	CD274_ENST00000381573.4_Intron|CD274_ENST00000498261.1_3'UTR	NM_014143.3	NP_054862.1	Q9NZQ7	PD1L1_HUMAN	CD274 molecule	57	Ig-like V-type.				cell proliferation|cell surface receptor linked signaling pathway|immune response|T cell costimulation	endomembrane system|integral to membrane	receptor activity			central_nervous_system(1)|kidney(1)|large_intestine(4)|lung(4)|ovary(1)	11	all_hematologic(13;0.158)	Acute lymphoblastic leukemia(23;0.154)		GBM - Glioblastoma multiforme(50;0.000742)|Lung(218;0.111)		TTGTCTATTGGGAAATGGAGG	0.428000			T	CIITA	"""PMBL, Hodgkin Lymphona, """								17	37					6.49762e-13	7.15242e-13	1	1	0
TBC1D23	55773	broad.mit.edu	37	3	100009530	100009530	+	Silent	SNP	C	C	A			TCGA-ZF-AA56-01A-31D-A391-08	TCGA-ZF-AA56-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85d9812c-68d6-4bdf-8674-bccf1eb0c8a8	26bda3c7-7369-4096-8905-08248b5bb9f1	g.chr3:100009530C>A	ENST00000394144.4	+	5	592	c.585C>A	c.(583-585)tcC>tcA	p.S195S	TBC1D23_ENST00000344949.5_Silent_p.S195S|TBC1D23_ENST00000486274.1_3'UTR|TBC1D23_ENST00000475134.1_Silent_p.S58S	NM_001199198.2	NP_001186127.1	Q9NUY8	TBC23_HUMAN	TBC1 domain family, member 23	195	Rab-GAP TBC.					intracellular	Rab GTPase activator activity			breast(1)|endometrium(1)|large_intestine(7)|liver(1)|lung(10)|ovary(1)|prostate(2)|skin(2)	25						CTCCAGACTCCTATGCACTCA	0.363000													7	178					3.09899e-07	3.33376e-07	1	1	0
DCAF8L2	347442	broad.mit.edu	37	X	27766666	27766666	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA56-01A-31D-A391-08	TCGA-ZF-AA56-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85d9812c-68d6-4bdf-8674-bccf1eb0c8a8	26bda3c7-7369-4096-8905-08248b5bb9f1	g.chrX:27766666G>A	ENST00000451261.2	+	5	2053	c.1654G>A	c.(1654-1656)Ggg>Agg	p.G552R		NM_001136533.1	NP_001130005.1			DDB1 and CUL4 associated factor 8-like 2											central_nervous_system(1)|endometrium(9)|kidney(3)|lung(7)|pancreas(1)|skin(3)	24						TGAGCTTACTGGGTTAAAGAA	0.502000													3	22					0	0	1	0	0
PDK3	5165	broad.mit.edu	37	X	24483621	24483621	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA56-01A-31D-A391-08	TCGA-ZF-AA56-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85d9812c-68d6-4bdf-8674-bccf1eb0c8a8	26bda3c7-7369-4096-8905-08248b5bb9f1	g.chrX:24483621G>A	ENST00000441463.2	+	1	49	c.49G>A	c.(49-51)Gag>Aag	p.E17K	PDK3_ENST00000379162.4_Missense_Mutation_p.E17K	NM_001142386.2	NP_001135858.1	Q15120	PDK3_HUMAN	pyruvate dehydrogenase kinase, isozyme 3	17					glucose metabolic process|peptidyl-histidine phosphorylation|pyruvate metabolic process|regulation of acetyl-CoA biosynthetic process from pyruvate	mitochondrial matrix	ATP binding|protein binding|pyruvate dehydrogenase (acetyl-transferring) kinase activity|two-component sensor activity			NS(1)|endometrium(5)|kidney(1)|large_intestine(1)|lung(12)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	23						CAAGCAGATCGAGCGCTACTC	0.701000													7	16					0	0	1	0	0
OR4C3	256144	broad.mit.edu	37	11	48346559	48346559	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-AA56-01A-31D-A391-08	TCGA-ZF-AA56-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85d9812c-68d6-4bdf-8674-bccf1eb0c8a8	26bda3c7-7369-4096-8905-08248b5bb9f1	g.chr11:48346559G>T	ENST00000319856.4	+	1	88	c.67G>T	c.(67-69)Gtg>Ttg	p.V23L		NM_001004702.1	NP_001004702.1	Q8NH37	OR4C3_HUMAN	olfactory receptor, family 4, subfamily C, member 3	177					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(18)|prostate(1)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)	32						TGCATTCTCAGTGACCTTGGA	0.383000													12	108					2.32078e-09	2.53501e-09	1	1	0
NOSIP	51070	broad.mit.edu	37	19	50060161	50060161	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA56-01A-31D-A391-08	TCGA-ZF-AA56-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85d9812c-68d6-4bdf-8674-bccf1eb0c8a8	26bda3c7-7369-4096-8905-08248b5bb9f1	g.chr19:50060161C>T	ENST00000391853.3	-	7	659	c.508G>A	c.(508-510)Gaa>Aaa	p.E170K	NOSIP_ENST00000339093.3_Missense_Mutation_p.E173K|NOSIP_ENST00000596358.1_Missense_Mutation_p.E170K	NM_015953.4	NP_057037.1	Q9Y314	NOSIP_HUMAN	nitric oxide synthase interacting protein	170					negative regulation of nitric-oxide synthase activity|nitric oxide metabolic process	cytosol|nucleus	protein binding			cervix(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(1)|ovary(1)|skin(2)|urinary_tract(1)	11		all_lung(116;7.84e-06)|Lung NSC(112;2.8e-05)|all_neural(266;0.0966)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.00321)|GBM - Glioblastoma multiforme(134;0.0133)		GCCTTGGCTTCGGGCGTCAGC	0.662000													3	14					0	0	1	0	0
CSH2	1443	broad.mit.edu	37	17	61949905	61949905	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA56-01A-31D-A391-08	TCGA-ZF-AA56-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85d9812c-68d6-4bdf-8674-bccf1eb0c8a8	26bda3c7-7369-4096-8905-08248b5bb9f1	g.chr17:61949905C>G	ENST00000336844.5	-	4	639	c.488G>C	c.(487-489)gGa>gCa	p.G163A	CSH2_ENST00000345366.7_Intron|CSH2_ENST00000560142.1_Intron|CSH2_ENST00000392886.2_Intron	NM_022644.3	NP_072170.1	P01243	CSH_HUMAN	chorionic somatomammotropin hormone 2	0					female pregnancy|signal transduction	extracellular region	hormone activity|metal ion binding			endometrium(2)|large_intestine(1)|lung(3)	6						CAGTGGGGTTCCAGGATTGGC	0.572000													12	117					0	0	1	0	0
KIAA1009	22832	broad.mit.edu	37	6	84904792	84904792	+	Splice_Site	SNP	A	A	C			TCGA-ZF-AA56-01A-31D-A391-08	TCGA-ZF-AA56-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85d9812c-68d6-4bdf-8674-bccf1eb0c8a8	26bda3c7-7369-4096-8905-08248b5bb9f1	g.chr6:84904792A>C	ENST00000403245.3	-	10	951	c.837T>G	c.(835-837)ggT>ggG	p.G279G	KIAA1009_ENST00000257766.4_Splice_Site_p.G203G	NM_014895.2	NP_055710.2	Q5TB80	QN1_HUMAN	KIAA1009	279					cell division|mitosis	centrosome|nucleus|plasma membrane|spindle	protein binding			breast(2)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(10)|lung(17)|ovary(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	43		all_cancers(76;1.5e-06)|Acute lymphoblastic leukemia(125;2.69e-07)|all_hematologic(105;0.000151)|all_epithelial(107;0.00258)		BRCA - Breast invasive adenocarcinoma(397;0.089)		CATAAGAAACACCTGTTGAAA	0.333000													4	13					0	0	1	0	0
JARID2	3720	broad.mit.edu	37	6	15410497	15410497	+	Nonsense_Mutation	SNP	C	C	G			TCGA-ZF-AA56-01A-31D-A391-08	TCGA-ZF-AA56-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85d9812c-68d6-4bdf-8674-bccf1eb0c8a8	26bda3c7-7369-4096-8905-08248b5bb9f1	g.chr6:15410497C>G	ENST00000341776.2	+	3	468	c.224C>G	c.(223-225)tCa>tGa	p.S75*	JARID2_ENST00000397311.3_5'UTR|JARID2_ENST00000541660.1_Nonsense_Mutation_p.S37*	NM_004973.3	NP_004964.2	Q92833	JARD2_HUMAN	jumonji, AT rich interactive domain 2	75					central nervous system development|chromatin modification|negative regulation of histone methylation|positive regulation of histone H3-K9 methylation|stem cell differentiation|transcription, DNA-dependent		chromatin binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(10)|kidney(2)|large_intestine(15)|lung(19)|ovary(3)|pancreas(1)|prostate(5)|stomach(1)	59	Breast(50;0.0142)|Ovarian(93;0.103)	all_hematologic(90;0.00612)				GGACCAGCATCAGAACAGTCA	0.463000													15	87					0	0	1	0	0
ADAM11	4185	broad.mit.edu	37	17	42847157	42847157	+	Silent	SNP	G	G	A			TCGA-ZF-AA56-01A-31D-A391-08	TCGA-ZF-AA56-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85d9812c-68d6-4bdf-8674-bccf1eb0c8a8	26bda3c7-7369-4096-8905-08248b5bb9f1	g.chr17:42847157G>A	ENST00000200557.6	+	3	478	c.309G>A	c.(307-309)ctG>ctA	p.L103L	ADAM11_ENST00000535346.1_5'UTR	NM_002390.4	NP_002381.2	O75078	ADA11_HUMAN	ADAM metallopeptidase domain 11	103					integrin-mediated signaling pathway|proteolysis	integral to membrane|plasma membrane	integrin binding|metalloendopeptidase activity|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|liver(2)|lung(15)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	33		Prostate(33;0.0959)				ACCTGGAGCTGAACCAGTGAG	0.652000													9	100					0	0	1	0	0
CHD3	1107	broad.mit.edu	37	17	7812116	7812116	+	Missense_Mutation	SNP	T	T	A			TCGA-ZF-AA56-01A-31D-A391-08	TCGA-ZF-AA56-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85d9812c-68d6-4bdf-8674-bccf1eb0c8a8	26bda3c7-7369-4096-8905-08248b5bb9f1	g.chr17:7812116T>A	ENST00000380358.4	+	36	5541	c.5540T>A	c.(5539-5541)aTg>aAg	p.M1847K	CHD3_ENST00000330494.7_Missense_Mutation_p.M1788K|CHD3_ENST00000358181.4_Missense_Mutation_p.M1754K	NM_001005271.2	NP_001005271.2	Q12873	CHD3_HUMAN	chromodomain helicase DNA binding protein 3	1788	Required for interaction with PCNT.				chromatin modification|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	microtubule organizing center|NuRD complex	ATP binding|ATP-dependent DNA helicase activity|DNA binding|protein binding|zinc ion binding			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(11)|kidney(6)|large_intestine(13)|liver(2)|lung(14)|ovary(1)|pancreas(1)|prostate(7)|skin(3)|urinary_tract(2)	65		Prostate(122;0.202)				TTTCTGGAGATGAAAAATAAG	0.483000													32	72					0	0	1	0	0
PIK3CA	5290	broad.mit.edu	37	3	178936082	178936082	+	Missense_Mutation	SNP	G	G	A	rs121913273		TCGA-ZF-AA56-01A-31D-A391-08	TCGA-ZF-AA56-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85d9812c-68d6-4bdf-8674-bccf1eb0c8a8	26bda3c7-7369-4096-8905-08248b5bb9f1	g.chr3:178936082G>A	ENST00000263967.3	+	10	1781	c.1624G>A	c.(1624-1626)Gaa>Aaa	p.E542K		NM_006218.2	NP_006209.2	P42336	PK3CA_HUMAN	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha	542	PI3K helical.		E -> K (in KERSEB; shows an increase in lipid kinase activity; oncogenic in vivo; occurs in the interface between the PI3K helical domain and the nSH2 (N-terminal SH2) region of the p85 regulatory subunit and may reduce the inhibitory effect of p85; requires interaction with RAS to induce cellular transformation).|E -> Q (in cancer).|E -> V (in cancer).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.E542K(545)|p.E542Q(10)		NS(16)|autonomic_ganglia(4)|biliary_tract(22)|bone(1)|breast(2150)|central_nervous_system(110)|cervix(33)|endometrium(473)|eye(1)|haematopoietic_and_lymphoid_tissue(35)|kidney(14)|large_intestine(1202)|liver(42)|lung(202)|meninges(1)|oesophagus(28)|ovary(235)|pancreas(17)|penis(8)|pituitary(12)|prostate(10)|skin(155)|small_intestine(1)|soft_tissue(18)|stomach(121)|thyroid(80)|upper_aerodigestive_tract(70)|urinary_tract(208)	5269	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			TCCTCTCTCTGAAATCACTGA	0.333000	E542K(BT483_BREAST)|E542K(CAL51_BREAST)|E542K(HGC27_STOMACH)|E542K(IM95_STOMACH)|E542K(JHUEM1_ENDOMETRIUM)|E542K(NCIH1341_LUNG)|E542K(SW948_LARGE_INTESTINE)|E542K(T84_LARGE_INTESTINE)|E542K(VMCUB1_URINARY_TRACT)	57	Mis		"""colorectal, gastric, gliobastoma, breast"""					HNSCC(19;0.045)|TSP Lung(28;0.18)			33	34					0	0	1	0	0
NPAS2	4862	broad.mit.edu	37	2	101584765	101584765	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-AA56-01A-31D-A391-08	TCGA-ZF-AA56-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85d9812c-68d6-4bdf-8674-bccf1eb0c8a8	26bda3c7-7369-4096-8905-08248b5bb9f1	g.chr2:101584765G>T	ENST00000335681.5	+	11	1215	c.930G>T	c.(928-930)aaG>aaT	p.K310N	NPAS2_ENST00000542504.1_Missense_Mutation_p.K375N	NM_002518.3	NP_002509.2	Q99743	NPAS2_HUMAN	neuronal PAS domain protein 2	310					central nervous system development|positive regulation of transcription from RNA polymerase II promoter|rhythmic process	transcription factor complex	DNA binding|Hsp90 protein binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			cervix(1)|endometrium(3)|large_intestine(7)|lung(9)|ovary(3)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29						GCAAAGGGAAGTCGTGTTGCT	0.443000													5	61					3.59834e-05	3.676e-05	1	1	0
MAT2B	27430	broad.mit.edu	37	5	162945242	162945242	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA56-01A-31D-A391-08	TCGA-ZF-AA56-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85d9812c-68d6-4bdf-8674-bccf1eb0c8a8	26bda3c7-7369-4096-8905-08248b5bb9f1	g.chr5:162945242C>T	ENST00000280969.5	+	7	1126	c.845C>T	c.(844-846)gCt>gTt	p.A282V	MAT2B_ENST00000518095.1_3'UTR|MAT2B_ENST00000321757.6_Missense_Mutation_p.A293V|MAT2B_ENST00000521838.2_3'UTR	NM_182796.1	NP_877725.1	Q9NZL9	MAT2B_HUMAN	methionine adenosyltransferase II, beta	293					extracellular polysaccharide biosynthetic process|methylation|S-adenosylmethionine biosynthetic process|xenobiotic metabolic process	cytosol|methionine adenosyltransferase complex|nucleus	dTDP-4-dehydrorhamnose reductase activity|methionine adenosyltransferase regulator activity|protein binding			endometrium(3)|large_intestine(4)|lung(6)|upper_aerodigestive_tract(1)	14	Renal(175;0.000281)	Medulloblastoma(196;0.0208)|all_neural(177;0.0765)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.027)|OV - Ovarian serous cystadenocarcinoma(192;0.0406)|Epithelial(171;0.0797)	L-Methionine(DB00134)|S-Adenosylmethionine(DB00118)	CCGAGAAATGCTCAGCTTGAC	0.408000													9	55					0	0	1	0	0
MYLK	4638	broad.mit.edu	37	3	123385188	123385188	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA56-01A-31D-A391-08	TCGA-ZF-AA56-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85d9812c-68d6-4bdf-8674-bccf1eb0c8a8	26bda3c7-7369-4096-8905-08248b5bb9f1	g.chr3:123385188G>A	ENST00000360772.3	-	23	4087	c.3709C>T	c.(3709-3711)Ccc>Tcc	p.P1237S	MYLK_ENST00000346322.5_Missense_Mutation_p.P1168S|MYLK_ENST00000354792.5_Missense_Mutation_p.P37S|MYLK_ENST00000475616.1_Missense_Mutation_p.P1237S|MYLK_ENST00000359169.1_Missense_Mutation_p.P1237S|MYLK_ENST00000510775.1_5'UTR|MYLK_ENST00000360304.3_Missense_Mutation_p.P1237S			Q15746	MYLK_HUMAN	myosin light chain kinase	1237	Actin-binding (calcium/calmodulin- insensitive) (By similarity).				aorta smooth muscle tissue morphogenesis|muscle contraction	cytosol	actin binding|ATP binding|calmodulin binding|metal ion binding|myosin light chain kinase activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(24)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(17)|lung(37)|ovary(7)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	113		Lung NSC(201;0.0496)		GBM - Glioblastoma multiforme(114;0.0736)		ATCTGAGGGGGCATTGCTGAG	0.557000													3	31					0	0	1	0	0
DHRSX	207063	broad.mit.edu	37	X	2209583	2209583	+	Silent	SNP	G	G	A			TCGA-ZF-AA56-01A-31D-A391-08	TCGA-ZF-AA56-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85d9812c-68d6-4bdf-8674-bccf1eb0c8a8	26bda3c7-7369-4096-8905-08248b5bb9f1	g.chrX:2209583G>A	ENST00000334651.5	-	4	400	c.348C>T	c.(346-348)ttC>ttT	p.F116F		NM_145177.2	NP_660160.2	Q8N5I4	DHRSX_HUMAN	dehydrogenase/reductase (SDR family) X-linked	116							binding|oxidoreductase activity	p.F116L(1)		endometrium(1)|kidney(1)|large_intestine(2)|lung(10)|ovary(1)|pancreas(1)	16		all_cancers(21;9e-05)|all_epithelial(21;6.22e-06)|all_lung(23;0.000597)|Lung NSC(23;0.00901)|Lung SC(21;0.186)				TCTTCATCTTGAACTTCTGCA	0.423000													18	130					0	0	1	0	0
ALDH1L2	160428	broad.mit.edu	37	12	105420454	105420454	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA56-01A-31D-A391-08	TCGA-ZF-AA56-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85d9812c-68d6-4bdf-8674-bccf1eb0c8a8	26bda3c7-7369-4096-8905-08248b5bb9f1	g.chr12:105420454C>G	ENST00000258494.9	-	22	2725	c.2585G>C	c.(2584-2586)aGa>aCa	p.R862T	C12orf45_ENST00000548583.1_Intron	NM_001034173.3	NP_001029345.2	Q3SY69	AL1L2_HUMAN	aldehyde dehydrogenase 1 family, member L2	862	Aldehyde dehydrogenase.				10-formyltetrahydrofolate catabolic process|biosynthetic process	mitochondrion	acyl carrier activity|cofactor binding|formyltetrahydrofolate dehydrogenase activity|hydroxymethyl-, formyl- and related transferase activity|methyltransferase activity|phosphopantetheine binding			breast(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(13)|prostate(2)|skin(3)|stomach(2)	35						GTTTATGTCTCTTGTAAAAAC	0.413000													25	146					0	0	1	0	0
LAMA5	3911	broad.mit.edu	37	20	60921737	60921737	+	Splice_Site	SNP	C	C	T			TCGA-ZF-AA56-01A-31D-A391-08	TCGA-ZF-AA56-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85d9812c-68d6-4bdf-8674-bccf1eb0c8a8	26bda3c7-7369-4096-8905-08248b5bb9f1	g.chr20:60921737C>T	ENST00000252999.3	-	8	1258		c.e8+1		LAMA5_ENST00000370692.3_Splice_Site|LAMA5_ENST00000370677.3_Splice_Site	NM_005560.3	NP_005551.3	O15230	LAMA5_HUMAN	laminin, alpha 5						angiogenesis|cell proliferation|cell recognition|cytoskeleton organization|endothelial cell differentiation|focal adhesion assembly|integrin-mediated signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-11 complex	integrin binding			breast(2)|central_nervous_system(3)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|lung(40)|ovary(1)|pancreas(1)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	81	Breast(26;1.57e-08)		BRCA - Breast invasive adenocarcinoma(19;4.36e-06)		Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GCCCAGCCCACCTGGCAGTCG	0.672000													6	21					0	0	1	0	0
MEP1B	4225	broad.mit.edu	37	18	29793442	29793442	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-AA56-01A-31D-A391-08	TCGA-ZF-AA56-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85d9812c-68d6-4bdf-8674-bccf1eb0c8a8	26bda3c7-7369-4096-8905-08248b5bb9f1	g.chr18:29793442C>A	ENST00000269202.6	+	11	1546	c.1499C>A	c.(1498-1500)aCa>aAa	p.T500K	MEP1B_ENST00000581447.1_Missense_Mutation_p.T500K	NM_005925.2	NP_005916.2	Q16820	MEP1B_HUMAN	meprin A, beta	500	MATH.				digestion|proteolysis	extracellular space|integral to plasma membrane	metalloendopeptidase activity|zinc ion binding			cervix(1)|endometrium(1)|kidney(2)|large_intestine(6)|lung(9)|ovary(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	23						GCCACAATGACACTTTTGGAT	0.433000													4	49					0.184627	0.185937	1	1	0
PDS5B	23047	broad.mit.edu	37	13	33262637	33262637	+	Missense_Mutation	SNP	A	A	C			TCGA-ZF-AA56-01A-31D-A391-08	TCGA-ZF-AA56-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85d9812c-68d6-4bdf-8674-bccf1eb0c8a8	26bda3c7-7369-4096-8905-08248b5bb9f1	g.chr13:33262637A>C	ENST00000315596.10	+	13	1586	c.1400A>C	c.(1399-1401)aAt>aCt	p.N467T		NM_015032.3	NP_055847.1	Q9NTI5	PDS5B_HUMAN	PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae)	467					cell division|cell proliferation|mitotic sister chromatid cohesion|negative regulation of cell proliferation	chromatin|nucleus	ATP binding|DNA binding|identical protein binding			NS(2)|breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(14)|lung(14)|ovary(5)|pancreas(1)|prostate(5)|skin(1)|upper_aerodigestive_tract(1)	62		Lung SC(185;0.0367)		all cancers(112;5.55e-06)|Epithelial(112;2.7e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00303)|BRCA - Breast invasive adenocarcinoma(63;0.0204)		GTTCCTCACAATTTAGAAACT	0.318000													25	64					0	0	1	0	0
PLEC	5339	broad.mit.edu	37	8	145003665	145003665	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA56-01A-31D-A391-08	TCGA-ZF-AA56-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85d9812c-68d6-4bdf-8674-bccf1eb0c8a8	26bda3c7-7369-4096-8905-08248b5bb9f1	g.chr8:145003665C>T	ENST00000322810.4	-	24	3578	c.3409G>A	c.(3409-3411)Gag>Aag	p.E1137K	PLEC_ENST00000356346.3_Missense_Mutation_p.E986K|PLEC_ENST00000357649.2_Missense_Mutation_p.E1004K|PLEC_ENST00000354958.2_Missense_Mutation_p.E978K|PLEC_ENST00000436759.2_Missense_Mutation_p.E1027K|PLEC_ENST00000345136.3_Missense_Mutation_p.E1000K|PLEC_ENST00000354589.3_Missense_Mutation_p.E1000K|PLEC_ENST00000527096.1_Missense_Mutation_p.E1023K|PLEC_ENST00000398774.2_Missense_Mutation_p.E968K	NM_201380.2	NP_958782.1	Q15149	PLEC_HUMAN	plectin	1137	Globular 1.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle			NS(1)|breast(3)|central_nervous_system(4)|cervix(7)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(8)|lung(57)|ovary(4)|pancreas(2)|prostate(11)|skin(9)|stomach(2)|upper_aerodigestive_tract(10)	137						GTGCGCGTCTCACAGGCCTCC	0.682000													7	16					0	0	1	0	0
CYGB	114757	broad.mit.edu	37	17	74527164	74527164	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA56-01A-31D-A391-08	TCGA-ZF-AA56-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85d9812c-68d6-4bdf-8674-bccf1eb0c8a8	26bda3c7-7369-4096-8905-08248b5bb9f1	g.chr17:74527164C>T	ENST00000293230.5	-	3	798	c.436G>A	c.(436-438)Gag>Aag	p.E146K	PRCD_ENST00000592432.1_Intron|CYGB_ENST00000589342.1_Intron|CYGB_ENST00000590175.1_Missense_Mutation_p.E81K|CYGB_ENST00000589145.1_Missense_Mutation_p.E81K	NM_134268.4	NP_599030.1	Q8WWM9	CYGB_HUMAN	cytoglobin	146	Globin.				response to oxidative stress	cytoplasm	heme binding|oxygen binding|oxygen transporter activity|peroxidase activity			breast(1)|endometrium(2)|large_intestine(1)|lung(2)|ovary(1)	7						CTCTGCGTCTCAGGTGGGAAG	0.642000													5	39					0	0	1	0	0
DPY19L4	286148	broad.mit.edu	37	8	95795951	95795951	+	Missense_Mutation	SNP	C	C	T	rs145622169		TCGA-ZF-AA56-01A-31D-A391-08	TCGA-ZF-AA56-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85d9812c-68d6-4bdf-8674-bccf1eb0c8a8	26bda3c7-7369-4096-8905-08248b5bb9f1	g.chr8:95795951C>T	ENST00000414645.2	+	17	1868	c.1769C>T	c.(1768-1770)gCg>gTg	p.A590V		NM_181787.2	NP_861452.2	Q7Z388	D19L4_HUMAN	dpy-19-like 4 (C. elegans)	590						integral to membrane				breast(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(2)|lung(6)|ovary(2)|prostate(2)	21	Breast(36;3.85e-06)					TTAATGGGTGCGATTAAATTA	0.388000													11	76					0	0	1	0	0
LCA5L	150082	broad.mit.edu	37	21	40777913	40777913	+	Silent	SNP	G	G	A			TCGA-ZF-AA56-01A-31D-A391-08	TCGA-ZF-AA56-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85d9812c-68d6-4bdf-8674-bccf1eb0c8a8	26bda3c7-7369-4096-8905-08248b5bb9f1	g.chr21:40777913G>A	ENST00000358268.2	-	10	2436	c.1908C>T	c.(1906-1908)ccC>ccT	p.P636P	LCA5L_ENST00000495240.1_5'UTR|WRB_ENST00000541890.1_Intron|LCA5L_ENST00000288350.3_Silent_p.P636P|LCA5L_ENST00000380671.2_Silent_p.P636P			O95447	LCA5L_HUMAN	Leber congenital amaurosis 5-like	636										breast(1)|cervix(1)|endometrium(3)|large_intestine(8)|lung(4)|pancreas(2)|prostate(2)|skin(2)|urinary_tract(1)	24		Prostate(19;1.2e-06)				AGGCCTGACTGGGAGGCAGGG	0.453000													13	52					0	0	1	0	0
IFI6	2537	broad.mit.edu	37	1	27992964	27992964	+	Silent	SNP	G	G	A			TCGA-ZF-AA56-01A-31D-A391-08	TCGA-ZF-AA56-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85d9812c-68d6-4bdf-8674-bccf1eb0c8a8	26bda3c7-7369-4096-8905-08248b5bb9f1	g.chr1:27992964G>A	ENST00000361157.6	-	5	448	c.321C>T	c.(319-321)gtC>gtT	p.V107V	IFI6_ENST00000339145.4_Silent_p.V115V|IFI6_ENST00000362020.4_Silent_p.V111V	NM_002038.3|NM_022872.2|NM_022873.2	NP_002029.3|NP_075010.1|NP_075011.1	P09912	IFI6_HUMAN	interferon, alpha-inducible protein 6	107					anti-apoptosis|negative regulation of caspase activity|negative regulation of mitochondrial depolarization|release of cytochrome c from mitochondria|type I interferon-mediated signaling pathway	integral to membrane|mitochondrion	protein binding			lung(1)|ovary(1)	2		Colorectal(325;3.46e-05)|all_lung(284;4.29e-05)|Lung NSC(340;7.75e-05)|Renal(390;0.00121)|Breast(348;0.0021)|Ovarian(437;0.00503)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0416)|OV - Ovarian serous cystadenocarcinoma(117;1.11e-24)|Colorectal(126;1.24e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00244)|KIRC - Kidney renal clear cell carcinoma(1967;0.0027)|STAD - Stomach adenocarcinoma(196;0.00303)|READ - Rectum adenocarcinoma(331;0.0419)		TATTACCTATGACGACGCTGC	0.542000													7	64					0	0	1	0	0
TRHR	7201	broad.mit.edu	37	8	110100339	110100339	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-AA56-01A-31D-A391-08	TCGA-ZF-AA56-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85d9812c-68d6-4bdf-8674-bccf1eb0c8a8	26bda3c7-7369-4096-8905-08248b5bb9f1	g.chr8:110100339T>C	ENST00000518632.1	+	2	949	c.598T>C	c.(598-600)Tat>Cat	p.Y200H	TRHR_ENST00000311762.2_Missense_Mutation_p.Y200H			P34981	TRFR_HUMAN	thyrotropin-releasing hormone receptor	200						integral to plasma membrane	thyrotropin-releasing hormone receptor activity	p.Y200H(1)		endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(12)|prostate(4)|skin(4)|urinary_tract(1)	37			OV - Ovarian serous cystadenocarcinoma(57;2.3e-11)			TGGTGTCTTTTATGTTGTGCC	0.388000													27	50					0	0	1	0	0
ATL1	51062	broad.mit.edu	37	14	51098998	51098998	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA56-01A-31D-A391-08	TCGA-ZF-AA56-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85d9812c-68d6-4bdf-8674-bccf1eb0c8a8	26bda3c7-7369-4096-8905-08248b5bb9f1	g.chr14:51098998C>G	ENST00000441560.2	+	14	2084	c.1603C>G	c.(1603-1605)Caa>Gaa	p.Q535E	ATL1_ENST00000357032.3_Missense_Mutation_p.Q540E|ATL1_ENST00000354525.4_Missense_Mutation_p.Q535E|ATL1_ENST00000358385.6_Missense_Mutation_p.Q540E	NM_001127713.1	NP_001121185.1	Q8WXF7	ATLA1_HUMAN	atlastin GTPase 1	540	Sufficient for membrane association.				axonogenesis|cell death|endoplasmic reticulum organization|protein homooligomerization	axon|endoplasmic reticulum membrane|Golgi cis cisterna|Golgi membrane|integral to membrane|microsome	GTP binding|GTPase activity|identical protein binding			central_nervous_system(1)|cervix(2)|large_intestine(4)|liver(1)|lung(6)|ovary(1)|skin(3)	18						TCTGTATCATCAAGCTTTCCC	0.333000													14	43					0	0	1	0	0
NLRP5	126206	broad.mit.edu	37	19	56539799	56539799	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA56-01A-31D-A391-08	TCGA-ZF-AA56-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85d9812c-68d6-4bdf-8674-bccf1eb0c8a8	26bda3c7-7369-4096-8905-08248b5bb9f1	g.chr19:56539799C>T	ENST00000390649.3	+	7	2200	c.2200C>T	c.(2200-2202)Cgg>Tgg	p.R734W		NM_153447.4	NP_703148.4	P59047	NALP5_HUMAN	NLR family, pyrin domain containing 5	734						mitochondrion|nucleolus	ATP binding			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|ovary(5)|skin(2)|stomach(4)|upper_aerodigestive_tract(2)	25		Colorectal(82;3.46e-05)|Ovarian(87;0.0481)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0326)		TCCGTATTTGCGGAAAATTCG	0.502000													44	136					0	0	1	0	0
ACTB	60	broad.mit.edu	37	7	5568128	5568128	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA56-01A-31D-A391-08	TCGA-ZF-AA56-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85d9812c-68d6-4bdf-8674-bccf1eb0c8a8	26bda3c7-7369-4096-8905-08248b5bb9f1	g.chr7:5568128G>A	ENST00000331789.5	-	4	777	c.586C>T	c.(586-588)Cgc>Tgc	p.R196C		NM_001101.3	NP_001092.1	P60709	ACTB_HUMAN	actin, beta	196					'de novo' posttranslational protein folding|adherens junction organization|axon guidance|blood coagulation|cell junction assembly|cellular component movement	cytoskeleton|cytosol|MLL5-L complex|NuA4 histone acetyltransferase complex|ribonucleoprotein complex	ATP binding|kinesin binding|nitric-oxide synthase binding|structural constituent of cytoskeleton			NS(1)|central_nervous_system(1)|large_intestine(2)|lung(2)|prostate(2)	8		Ovarian(82;0.0606)		UCEC - Uterine corpus endometrioid carcinoma (126;0.175)|OV - Ovarian serous cystadenocarcinoma(56;4.24e-37)		CTGTAGCCGCGCTCGGTGAGG	0.612000													30	48					0	0	1	0	0
PPP1R16B	26051	broad.mit.edu	37	20	37464799	37464799	+	Silent	SNP	G	G	A			TCGA-ZF-AA56-01A-31D-A391-08	TCGA-ZF-AA56-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85d9812c-68d6-4bdf-8674-bccf1eb0c8a8	26bda3c7-7369-4096-8905-08248b5bb9f1	g.chr20:37464799G>A	ENST00000299824.1	+	2	420	c.231G>A	c.(229-231)ctG>ctA	p.L77L	PPP1R16B_ENST00000468265.1_3'UTR|PPP1R16B_ENST00000373331.2_Silent_p.L77L	NM_015568.2	NP_056383.1	Q96T49	PP16B_HUMAN	protein phosphatase 1, regulatory subunit 16B	77					regulation of filopodium assembly|signal transduction	nucleus|plasma membrane	protein phosphatase binding			biliary_tract(1)|endometrium(4)|kidney(3)|large_intestine(10)|lung(23)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)	49		Myeloproliferative disorder(115;0.00878)				AGGCCTCGCTGAGGAACGACG	0.647000													4	38					0	0	1	0	0
AMY2A	279	broad.mit.edu	37	1	104160207	104160207	+	Missense_Mutation	SNP	C	C	T	rs147709536		TCGA-ZF-AA56-01A-31D-A391-08	TCGA-ZF-AA56-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85d9812c-68d6-4bdf-8674-bccf1eb0c8a8	26bda3c7-7369-4096-8905-08248b5bb9f1	g.chr1:104160207C>T	ENST00000414303.2	+	1	209	c.145C>T	c.(145-147)Ccg>Tcg	p.P49S		NM_000699.2	NP_000690.1	P04746	AMYP_HUMAN	amylase, alpha 2A (pancreatic)	49					carbohydrate catabolic process|polysaccharide digestion	extracellular space	alpha-amylase activity|calcium ion binding|chloride ion binding			endometrium(3)|kidney(1)|large_intestine(5)|liver(3)|lung(5)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	22		all_epithelial(167;3.05e-05)|all_lung(203;0.000199)|Lung NSC(277;0.000451)		Colorectal(144;0.0654)|all cancers(265;0.0808)|Epithelial(280;0.0921)|Lung(183;0.111)	Acarbose(DB00284)|Bentiromide(DB00522)|Icodextrin(DB00702)|Miglitol(DB00491)|Pancrelipase(DB00085)	ATATTTAGCTCCGAAGGGATT	0.413000													62	321					0	0	1	0	0
EPB41L1	2036	broad.mit.edu	37	20	34773198	34773198	+	Silent	SNP	C	C	T	rs142551778	byFrequency	TCGA-ZF-AA56-01A-31D-A391-08	TCGA-ZF-AA56-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85d9812c-68d6-4bdf-8674-bccf1eb0c8a8	26bda3c7-7369-4096-8905-08248b5bb9f1	g.chr20:34773198C>T	ENST00000338074.2	+	7	887	c.726C>T	c.(724-726)ttC>ttT	p.F242F	EPB41L1_ENST00000373950.2_Silent_p.F145F|EPB41L1_ENST00000373946.3_Silent_p.F211F|EPB41L1_ENST00000441639.1_Silent_p.F180F|EPB41L1_ENST00000202028.5_Silent_p.F180F|EPB41L1_ENST00000373941.1_Silent_p.F242F	NM_001258329.1|NM_012156.2	NP_001245258.1|NP_036288.2	Q9H4G0	E41L1_HUMAN	erythrocyte membrane protein band 4.1-like 1	242	FERM.				cortical actin cytoskeleton organization|synaptic transmission	cytoskeleton|cytosol|extrinsic to membrane|plasma membrane	actin binding|structural molecule activity			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(10)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	37	Breast(12;0.0239)					AGCTCCGCTTCGCCCCTAACC	0.592000													22	33					0	0	1	0	0
MSH6	2956	broad.mit.edu	37	2	48032803	48032803	+	Silent	SNP	C	C	G	rs63751434		TCGA-ZF-AA56-01A-31D-A391-08	TCGA-ZF-AA56-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85d9812c-68d6-4bdf-8674-bccf1eb0c8a8	26bda3c7-7369-4096-8905-08248b5bb9f1	g.chr2:48032803C>G	ENST00000234420.5	+	7	3755	c.3603C>G	c.(3601-3603)ctC>ctG	p.L1201L	MSH6_ENST00000540021.1_Silent_p.L1071L|MSH6_ENST00000538136.1_Silent_p.L899L|FBXO11_ENST00000405808.1_Intron	NM_000179.2	NP_000170.1	P52701	MSH6_HUMAN	mutS homolog 6						determination of adult lifespan|DNA damage response, signal transduction resulting in induction of apoptosis|isotype switching|meiotic mismatch repair|negative regulation of DNA recombination|positive regulation of helicase activity|reciprocal meiotic recombination|response to UV|somatic hypermutation of immunoglobulin genes	MutSalpha complex	ATP binding|DNA-dependent ATPase activity|protein binding	p.0?(2)		breast(8)|central_nervous_system(29)|cervix(1)|endometrium(32)|haematopoietic_and_lymphoid_tissue(12)|kidney(2)|large_intestine(75)|lung(25)|ovary(3)|prostate(3)|skin(10)|stomach(22)|thyroid(1)|upper_aerodigestive_tract(1)|urinary_tract(5)	229		Acute lymphoblastic leukemia(82;0.0299)|all_hematologic(82;0.0358)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)			CCAGCATACTCATGCATGCAA	0.294000			"""Mis, N, F, S"""		colorectal	"""colorectal, endometrial, ovarian"""		Mismatch excision repair (MMR)	Turcot syndrome;Muir-Torre syndrome;Lynch syndrome;Constitutional Mismatch Repair Deficiency Syndrome				7	103					0	0	1	0	0
MIS18BP1	55320	broad.mit.edu	37	14	45711439	45711439	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA56-01A-31D-A391-08	TCGA-ZF-AA56-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85d9812c-68d6-4bdf-8674-bccf1eb0c8a8	26bda3c7-7369-4096-8905-08248b5bb9f1	g.chr14:45711439G>A	ENST00000310806.4	-	4	1399	c.941C>T	c.(940-942)tCg>tTg	p.S314L	MIS18BP1_ENST00000492652.1_5'UTR	NM_018353.4	NP_060823.3	Q6P0N0	M18BP_HUMAN	MIS18 binding protein 1	314					cell division|CenH3-containing nucleosome assembly at centromere|mitosis	chromosome, centromeric region|nucleoplasm	DNA binding			NS(1)|breast(2)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(10)|liver(1)|lung(13)|ovary(2)|pancreas(1)|prostate(1)|skin(2)	39						TTTCTGTTGCGAAGTCCCTTC	0.393000													20	71					0	0	1	0	0
SP100	6672	broad.mit.edu	37	2	231406669	231406669	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA56-01A-31D-A391-08	TCGA-ZF-AA56-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85d9812c-68d6-4bdf-8674-bccf1eb0c8a8	26bda3c7-7369-4096-8905-08248b5bb9f1	g.chr2:231406669G>C	ENST00000340126.4	+	28	2497	c.2466G>C	c.(2464-2466)ttG>ttC	p.L822F	AC010149.4_ENST00000414539.1_RNA|AC010149.4_ENST00000455357.1_RNA	NM_001080391.1	NP_001073860.1	P23497	SP100_HUMAN	SP100 nuclear antigen	0					DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|interspecies interaction between organisms|negative regulation of cellular component movement|negative regulation of DNA binding|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|negative regulation of viral transcription|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|response to cytokine stimulus|response to retinoic acid|response to type I interferon	cytoplasm|nuclear periphery|nucleolus|PML body	chromo shadow domain binding|DNA binding|identical protein binding|kinase binding|protein homodimerization activity|transcription coactivator activity|transcription corepressor activity|transcription factor binding			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(4)|lung(12)|ovary(4)|upper_aerodigestive_tract(1)	25		Renal(207;0.0112)|all_lung(227;0.0335)|all_hematologic(139;0.0749)|Lung NSC(271;0.142)|Acute lymphoblastic leukemia(138;0.167)		Epithelial(121;1.13e-12)|all cancers(144;2.71e-10)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.00942)		AGACAAGTTTGAATGAGCAGA	0.478000													8	59					0	0	1	0	0
ADAMTS20	80070	broad.mit.edu	37	12	43833793	43833793	+	Silent	SNP	T	T	C			TCGA-ZF-AA56-01A-31D-A391-08	TCGA-ZF-AA56-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85d9812c-68d6-4bdf-8674-bccf1eb0c8a8	26bda3c7-7369-4096-8905-08248b5bb9f1	g.chr12:43833793T>C	ENST00000389420.3	-	17	2369	c.2370A>G	c.(2368-2370)caA>caG	p.Q790Q	ADAMTS20_ENST00000553158.1_Silent_p.Q790Q	NM_025003.3	NP_079279.3	P59510	ATS20_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 20	790	Spacer.					proteinaceous extracellular matrix	zinc ion binding			breast(1)|central_nervous_system(6)|endometrium(3)|kidney(4)|large_intestine(11)|liver(1)|lung(43)|ovary(4)|pancreas(3)|prostate(5)|skin(12)|upper_aerodigestive_tract(1)|urinary_tract(1)	95	all_cancers(12;2.6e-05)|Lung SC(27;0.184)	Lung NSC(34;0.0569)|all_lung(34;0.129)		GBM - Glioblastoma multiforme(48;0.0473)		TTCTTGTTCCTTGCACATTGA	0.303000													5	14					0	0	1	0	0
TXNIP	10628	broad.mit.edu	37	1	145440746	145440746	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA56-01A-31D-A391-08	TCGA-ZF-AA56-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85d9812c-68d6-4bdf-8674-bccf1eb0c8a8	26bda3c7-7369-4096-8905-08248b5bb9f1	g.chr1:145440746G>C	ENST00000369317.4	+	6	1280	c.946G>C	c.(946-948)Gag>Cag	p.E316Q	TXNIP_ENST00000475171.1_Intron	NM_006472.3	NP_006463.3	Q9H3M7	TXNIP_HUMAN	thioredoxin interacting protein	316					cell cycle|keratinocyte differentiation|transcription, DNA-dependent		ubiquitin protein ligase binding			breast(3)|cervix(1)|endometrium(1)|kidney(4)|large_intestine(1)|lung(5)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)	21	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					AACCAGCTCTGAGATGAGTTG	0.493000													4	56					0	0	1	0	0
STK32B	55351	broad.mit.edu	37	4	5461922	5461922	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-AA56-01A-31D-A391-08	TCGA-ZF-AA56-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85d9812c-68d6-4bdf-8674-bccf1eb0c8a8	26bda3c7-7369-4096-8905-08248b5bb9f1	g.chr4:5461922C>A	ENST00000282908.5	+	9	1298	c.876C>A	c.(874-876)ttC>ttA	p.F292L	STK32B_ENST00000510398.1_Missense_Mutation_p.F245L|STK32B_ENST00000512636.1_Missense_Mutation_p.F215L|STK32B_ENST00000508728.1_3'UTR	NM_018401.1	NP_060871.1	Q9NY57	ST32B_HUMAN	serine/threonine kinase 32B	292							ATP binding|metal ion binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(10)|lung(16)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)	39						ACGCGGTGTTCAAGAAGGCAC	0.587000											OREG0016061	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	8	75					1.12685e-05	1.17656e-05	1	1	0
AXIN2	8313	broad.mit.edu	37	17	63554211	63554211	+	Silent	SNP	G	G	A			TCGA-ZF-AA56-01A-31D-A391-08	TCGA-ZF-AA56-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85d9812c-68d6-4bdf-8674-bccf1eb0c8a8	26bda3c7-7369-4096-8905-08248b5bb9f1	g.chr17:63554211G>A	ENST00000307078.5	-	2	841	c.528C>T	c.(526-528)acC>acT	p.T176T	CTD-2535L24.2_ENST00000577662.1_3'UTR|AXIN2_ENST00000375702.5_Silent_p.T176T	NM_004655.3	NP_004646.3	Q9Y2T1	AXIN2_HUMAN	axin 2	176	RGS.				cellular protein localization|cellular response to organic cyclic compound|dorsal/ventral axis specification|intramembranous ossification|maintenance of DNA repeat elements|mRNA stabilization|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of catenin import into nucleus|negative regulation of cell proliferation|negative regulation of osteoblast differentiation|odontogenesis|positive regulation of cell death|positive regulation of epithelial to mesenchymal transition|positive regulation of protein phosphorylation|regulation of centromeric sister chromatid cohesion|regulation of mismatch repair|Wnt receptor signaling pathway involved in somitogenesis	Axin-APC-beta-catenin-GSK3B complex|cell cortex|centrosome|cytoplasmic membrane-bounded vesicle|cytoplasmic microtubule|nucleus|plasma membrane|postsynaptic density	armadillo repeat domain binding|beta-catenin binding|GTPase activator activity|protein kinase binding|signal transducer activity|ubiquitin protein ligase binding			NS(1)|central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(10)|lung(10)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	34						ACTGGATCTCGGTCTGCGCCT	0.473000									Oligodontia, Ectodermal Dysplasia and Colorectal Polyp syndrome				8	43					0	0	1	0	0
POLR1A	25885	broad.mit.edu	37	2	86274333	86274333	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-AA56-01A-31D-A391-08	TCGA-ZF-AA56-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85d9812c-68d6-4bdf-8674-bccf1eb0c8a8	26bda3c7-7369-4096-8905-08248b5bb9f1	g.chr2:86274333C>A	ENST00000263857.6	-	19	3066	c.2688G>T	c.(2686-2688)atG>atT	p.M896I	POLR1A_ENST00000409681.1_Missense_Mutation_p.M896I			O95602	RPA1_HUMAN	polymerase (RNA) I polypeptide A, 194kDa	896				M -> L (in Ref. 1; AAC99959).	termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription initiation from RNA polymerase I promoter	DNA-directed RNA polymerase I complex|nucleoplasm	DNA binding|DNA-directed RNA polymerase activity|protein binding|zinc ion binding			NS(1)|breast(4)|cervix(2)|endometrium(8)|kidney(3)|large_intestine(12)|liver(1)|lung(20)|ovary(3)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	63						ACTGCACCATCATCTGCAGGC	0.522000													18	59					4.35082e-09	4.71615e-09	1	1	0
RNF213	57674	broad.mit.edu	37	17	78363030	78363030	+	Missense_Mutation	SNP	G	G	A	rs151136922		TCGA-ZF-AA56-01A-31D-A391-08	TCGA-ZF-AA56-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85d9812c-68d6-4bdf-8674-bccf1eb0c8a8	26bda3c7-7369-4096-8905-08248b5bb9f1	g.chr17:78363030G>A	ENST00000582970.1	+	65	15201	c.15058G>A	c.(15058-15060)Gat>Aat	p.D5020N	CTD-2047H16.4_ENST00000575034.1_RNA|RNF213_ENST00000336301.6_Missense_Mutation_p.D3093N|RNF213_ENST00000508628.2_Missense_Mutation_p.D5069N|CTD-2047H16.4_ENST00000572151.1_RNA|RNF213_ENST00000427003.3_3'UTR|CTD-2047H16.4_ENST00000573394.1_RNA	NM_001256071.1	NP_001243000.1	Q9HCF4	ALO17_HUMAN	ring finger protein 213	0										NS(1)|breast(7)|central_nervous_system(1)|cervix(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(23)|lung(36)|ovary(11)|pancreas(2)|prostate(4)|skin(3)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	130	all_neural(118;0.0538)		BRCA - Breast invasive adenocarcinoma(99;0.0252)|OV - Ovarian serous cystadenocarcinoma(97;0.057)			GTCCTACAGCGATGCCTGTGA	0.532000													27	99					0	0	1	0	0
DCAF13	25879	broad.mit.edu	37	8	104453809	104453809	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA56-01A-31D-A391-08	TCGA-ZF-AA56-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85d9812c-68d6-4bdf-8674-bccf1eb0c8a8	26bda3c7-7369-4096-8905-08248b5bb9f1	g.chr8:104453809C>G	ENST00000297579.5	+	10	1946	c.1669C>G	c.(1669-1671)Cag>Gag	p.Q557E		NM_015420.6	NP_056235.4	Q9NV06	DCA13_HUMAN	DDB1 and CUL4 associated factor 13	405					rRNA processing	CUL4 RING ubiquitin ligase complex|nucleolus|ribonucleoprotein complex				NS(1)|breast(1)|kidney(2)|large_intestine(8)|lung(8)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	25						TAGCCAGATTCAGGAACAGCG	0.383000													9	118					0	0	1	0	0
FNDC4	64838	broad.mit.edu	37	2	27716338	27716338	+	Silent	SNP	G	G	A			TCGA-ZF-AA56-01A-31D-A391-08	TCGA-ZF-AA56-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85d9812c-68d6-4bdf-8674-bccf1eb0c8a8	26bda3c7-7369-4096-8905-08248b5bb9f1	g.chr2:27716338G>A	ENST00000264703.3	-	5	853	c.462C>T	c.(460-462)atC>atT	p.I154I		NM_022823.2	NP_073734.1	Q9H6D8	FNDC4_HUMAN	fibronectin type III domain containing 4	154						integral to membrane				NS(1)|endometrium(2)|kidney(1)|large_intestine(1)|liver(2)|prostate(1)|skin(1)	9	Acute lymphoblastic leukemia(172;0.155)					CTTCCACTGTGATGTCACCTG	0.552000													35	131					0	0	1	0	0
SUCO	51430	broad.mit.edu	37	1	172579279	172579279	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-AA56-01A-31D-A391-08	TCGA-ZF-AA56-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85d9812c-68d6-4bdf-8674-bccf1eb0c8a8	26bda3c7-7369-4096-8905-08248b5bb9f1	g.chr1:172579279G>T	ENST00000367723.4	+	23	4222	c.4098G>T	c.(4096-4098)ttG>ttT	p.L1366F	SUCO_ENST00000608151.1_Missense_Mutation_p.L1367F|SUCO_ENST00000263688.3_Missense_Mutation_p.L1215F|SUCO_ENST00000610051.1_Missense_Mutation_p.L844F	NM_016227.2	NP_057311.3			SUN domain containing ossification factor																		AAGGAAAATTGATAAAAACTC	0.413000													8	38					1.12685e-05	1.17656e-05	1	1	0
ABCB7	22	broad.mit.edu	37	X	74288844	74288844	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA56-01A-31D-A391-08	TCGA-ZF-AA56-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85d9812c-68d6-4bdf-8674-bccf1eb0c8a8	26bda3c7-7369-4096-8905-08248b5bb9f1	g.chrX:74288844G>C	ENST00000253577.3	-	12	1684	c.1660C>G	c.(1660-1662)Cag>Gag	p.Q554E	ABCB7_ENST00000339447.4_Missense_Mutation_p.Q513E|ABCB7_ENST00000373394.3_Missense_Mutation_p.Q553E|ABCB7_ENST00000534570.1_5'UTR	NM_001271696.1|NM_004299.3	NP_001258625.1|NP_004290.2	O75027	ABCB7_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 7	553	ABC transporter.				cellular iron ion homeostasis	integral to membrane|mitochondrial inner membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|heme transporter activity			breast(1)|endometrium(5)|large_intestine(5)|lung(6)|ovary(2)|prostate(1)	20						TTAAATACCTGAGGTACCACT	0.398000													18	108					0	0	1	0	0
CNTNAP2	26047	broad.mit.edu	37	7	148112657	148112657	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-AA56-01A-31D-A391-08	TCGA-ZF-AA56-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85d9812c-68d6-4bdf-8674-bccf1eb0c8a8	26bda3c7-7369-4096-8905-08248b5bb9f1	g.chr7:148112657C>A	ENST00000361727.3	+	24	4461	c.3945C>A	c.(3943-3945)gaC>gaA	p.D1315E	CNTNAP2_ENST00000463592.2_3'UTR|CNTNAP2_ENST00000538075.1_Missense_Mutation_p.D374E	NM_014141.5	NP_054860.1	Q9UHC6	CNTP2_HUMAN	contactin associated protein-like 2	1315					behavior|cell adhesion|clustering of voltage-gated potassium channels|limbic system development|neuron recognition|signal transduction|striatum development|superior temporal gyrus development|thalamus development|transmission of nerve impulse	axolemma|cell body fiber|dendrite|juxtaparanode region of axon|voltage-gated potassium channel complex	receptor binding			NS(3)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(21)|lung(105)|ovary(9)|pancreas(2)|prostate(5)|skin(7)|stomach(3)|upper_aerodigestive_tract(6)|urinary_tract(3)	188	Melanoma(164;0.153)	all_cancers(3;3.51e-10)|all_epithelial(3;1.4e-05)|Myeloproliferative disorder(3;0.00452)|Lung NSC(3;0.0067)|all_lung(3;0.00794)	OV - Ovarian serous cystadenocarcinoma(82;0.0319)			TGAACAACGACCCCAACTTCA	0.547000										HNSCC(39;0.1)			12	54					1.36491e-13	1.5142e-13	1	1	0
OR56B1	387748	broad.mit.edu	37	11	5757852	5757852	+	Silent	SNP	C	C	T			TCGA-ZF-AA56-01A-31D-A391-08	TCGA-ZF-AA56-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85d9812c-68d6-4bdf-8674-bccf1eb0c8a8	26bda3c7-7369-4096-8905-08248b5bb9f1	g.chr11:5757852C>T	ENST00000317121.3	+	1	172	c.106C>T	c.(106-108)Cta>Tta	p.L36L	TRIM5_ENST00000380027.1_Intron	NM_001005180.2	NP_001005180.1	Q8NGI3	O56B1_HUMAN	olfactory receptor, family 56, subfamily B, member 1	36					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(7)|prostate(1)|skin(1)	13		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.086)		Epithelial(150;1.74e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)|LUSC - Lung squamous cell carcinoma(625;0.184)		GCAACACTGGCTATCTCTGCC	0.498000													12	50					0	0	1	0	0
BNIP3P1	319138	broad.mit.edu	37	14	28733724	28733724	+	RNA	SNP	C	C	T			TCGA-ZF-AA56-01A-31D-A391-08	TCGA-ZF-AA56-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85d9812c-68d6-4bdf-8674-bccf1eb0c8a8	26bda3c7-7369-4096-8905-08248b5bb9f1	g.chr14:28733724C>T	ENST00000550043.1	+	0	129																											CGCAGCCCGGCGCGGACTCCG	0.726000													5	5					0	0	1	0	0
BACH2	60468	broad.mit.edu	37	6	90647930	90647930	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA56-01A-31D-A391-08	TCGA-ZF-AA56-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85d9812c-68d6-4bdf-8674-bccf1eb0c8a8	26bda3c7-7369-4096-8905-08248b5bb9f1	g.chr6:90647930G>A	ENST00000257749.4	-	8	2683	c.1976C>T	c.(1975-1977)gCg>gTg	p.A659V	BACH2_ENST00000343122.3_Missense_Mutation_p.A659V|BACH2_ENST00000537989.1_Missense_Mutation_p.A659V	NM_021813.2	NP_068585.1	Q9BYV9	BACH2_HUMAN	BTB and CNC homology 1, basic leucine zipper transcription factor 2	659						nucleus	protein dimerization activity|sequence-specific DNA binding			central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(18)|ovary(5)|pancreas(1)|prostate(1)|skin(3)|urinary_tract(1)	45		all_cancers(76;7.37e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.0063)		BRCA - Breast invasive adenocarcinoma(108;0.0799)		GCGCTGGGCCGCGATGCGGTT	0.463000													4	84					0	0	1	0	0
NELL2	4753	broad.mit.edu	37	12	45000987	45000987	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-AA56-01A-31D-A391-08	TCGA-ZF-AA56-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85d9812c-68d6-4bdf-8674-bccf1eb0c8a8	26bda3c7-7369-4096-8905-08248b5bb9f1	g.chr12:45000987C>A	ENST00000429094.2	-	15	2132	c.1628G>T	c.(1627-1629)tGc>tTc	p.C543F	NELL2_ENST00000549027.1_Missense_Mutation_p.C542F|NELL2_ENST00000437801.2_Missense_Mutation_p.C593F|NELL2_ENST00000333837.4_Missense_Mutation_p.C566F|NELL2_ENST00000395487.2_Missense_Mutation_p.C542F|NELL2_ENST00000551601.1_Missense_Mutation_p.C542F|NELL2_ENST00000452445.2_Missense_Mutation_p.C543F	NM_001145108.1	NP_001138580.1	Q99435	NELL2_HUMAN	NEL-like 2 (chicken)	543	EGF-like 4.				cell adhesion	extracellular region	calcium ion binding|protein binding|structural molecule activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(16)|lung(30)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	65	Lung SC(27;0.192)	Lung NSC(34;0.144)		GBM - Glioblastoma multiforme(48;0.092)		GCCTTGTGGGCAGGCACACAC	0.393000													5	31					1.23904e-05	1.28426e-05	1	1	0
SEC31A	22872	broad.mit.edu	37	4	83770122	83770122	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA56-01A-31D-A391-08	TCGA-ZF-AA56-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85d9812c-68d6-4bdf-8674-bccf1eb0c8a8	26bda3c7-7369-4096-8905-08248b5bb9f1	g.chr4:83770122G>C	ENST00000432794.1	-	20	2500	c.2337C>G	c.(2335-2337)atC>atG	p.I779M	SEC31A_ENST00000508479.1_Missense_Mutation_p.I779M|SEC31A_ENST00000264405.5_Missense_Mutation_p.I512M|SEC31A_ENST00000509142.1_Missense_Mutation_p.I779M|SEC31A_ENST00000395310.2_Missense_Mutation_p.I779M|SEC31A_ENST00000500777.2_Missense_Mutation_p.I740M|SEC31A_ENST00000505984.1_Missense_Mutation_p.I740M|SEC31A_ENST00000348405.4_Missense_Mutation_p.I740M|SEC31A_ENST00000355196.2_Missense_Mutation_p.I779M|SEC31A_ENST00000505472.1_Missense_Mutation_p.I779M|SEC31A_ENST00000311785.7_Missense_Mutation_p.I779M|SEC31A_ENST00000508502.1_Missense_Mutation_p.I779M|SEC31A_ENST00000443462.2_Missense_Mutation_p.I774M|SEC31A_ENST00000448323.1_Missense_Mutation_p.I779M|SEC31A_ENST00000513858.1_Missense_Mutation_p.I740M|SEC31A_ENST00000326950.5_Missense_Mutation_p.I740M			O94979	SC31A_HUMAN	SEC31 homolog A (S. cerevisiae)	779					COPII vesicle coating|post-translational protein modification|protein N-linked glycosylation via asparagine|protein transport|response to calcium ion	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|perinuclear region of cytoplasm	calcium-dependent protein binding		SEC31A/ALK(3)|SEC31A/JAK2(4)	breast(1)	1		Hepatocellular(203;0.114)				GAAGCTGCATGATATTTGGCT	0.418000													11	92					0	0	1	0	0
TAOK1	57551	broad.mit.edu	37	17	27829655	27829655	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA56-01A-31D-A391-08	TCGA-ZF-AA56-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85d9812c-68d6-4bdf-8674-bccf1eb0c8a8	26bda3c7-7369-4096-8905-08248b5bb9f1	g.chr17:27829655G>A	ENST00000261716.3	+	13	1771	c.1252G>A	c.(1252-1254)Gat>Aat	p.D418N	TAOK1_ENST00000536202.1_Missense_Mutation_p.D418N	NM_020791.2	NP_065842.1	Q7L7X3	TAOK1_HUMAN	TAO kinase 1	418					mitotic prometaphase	cytosol|intracellular membrane-bounded organelle	ATP binding|protein serine/threonine kinase activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|large_intestine(4)|lung(14)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	28			Colorectal(6;0.198)			AAGAGCATCAGATCCACAATC	0.388000													14	42					0	0	1	0	0
C9orf50	375759	broad.mit.edu	37	9	132381833	132381833	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA56-01A-31D-A391-08	TCGA-ZF-AA56-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85d9812c-68d6-4bdf-8674-bccf1eb0c8a8	26bda3c7-7369-4096-8905-08248b5bb9f1	g.chr9:132381833G>C	ENST00000372478.4	-	3	883	c.682C>G	c.(682-684)Cac>Gac	p.H228D	NTMT1_ENST00000372486.1_Intron	NM_199350.3	NP_955382.3	Q5SZB4	CI050_HUMAN	chromosome 9 open reading frame 50	228										central_nervous_system(1)|endometrium(4)|large_intestine(2)|ovary(1)|skin(1)|urinary_tract(1)	10		Ovarian(14;0.00556)				AATTGTGAGTGATCACCCTTC	0.517000													34	70					0	0	1	0	0
OR4C6	219432	broad.mit.edu	37	11	55433083	55433083	+	Nonsense_Mutation	SNP	G	G	A			TCGA-ZF-AA56-01A-31D-A391-08	TCGA-ZF-AA56-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85d9812c-68d6-4bdf-8674-bccf1eb0c8a8	26bda3c7-7369-4096-8905-08248b5bb9f1	g.chr11:55433083G>A	ENST00000314259.3	+	1	470	c.441G>A	c.(439-441)tgG>tgA	p.W147*		NM_001004704.1	NP_001004704.1	Q8NH72	OR4C6_HUMAN	olfactory receptor, family 4, subfamily C, member 6	147					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(4)|lung(49)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	71						GAGGGGCTTGGGTGGGGGGAT	0.473000													18	64					0	0	1	0	0
TAAR6	319100	broad.mit.edu	37	6	132891840	132891840	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA56-01A-31D-A391-08	TCGA-ZF-AA56-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85d9812c-68d6-4bdf-8674-bccf1eb0c8a8	26bda3c7-7369-4096-8905-08248b5bb9f1	g.chr6:132891840C>T	ENST00000275198.1	+	1	380	c.380C>T	c.(379-381)tCc>tTc	p.S127F		NM_175067.1	NP_778237.1	Q96RI8	TAAR6_HUMAN	trace amine associated receptor 6	127						plasma membrane	G-protein coupled receptor activity			cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|liver(2)|lung(19)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	41	Breast(56;0.112)			OV - Ovarian serous cystadenocarcinoma(155;0.006)|GBM - Glioblastoma multiforme(226;0.00792)		TGCTTCATCTCCATCGACAGG	0.488000													80	128					0	0	1	0	0
JDP2	122953	broad.mit.edu	37	14	75904727	75904727	+	Missense_Mutation	SNP	T	T	G			TCGA-ZF-AA56-01A-31D-A391-08	TCGA-ZF-AA56-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85d9812c-68d6-4bdf-8674-bccf1eb0c8a8	26bda3c7-7369-4096-8905-08248b5bb9f1	g.chr14:75904727T>G	ENST00000435893.2	+	2	377	c.104T>G	c.(103-105)cTg>cGg	p.L35R	JDP2_ENST00000267569.5_Missense_Mutation_p.L46R|JDP2_ENST00000559773.1_3'UTR|JDP2_ENST00000437176.1_Missense_Mutation_p.L35R|JDP2_ENST00000419727.2_Missense_Mutation_p.L35R	NM_001135047.1|NM_130469.3	NP_001128519.1|NP_569736.1	Q8WYK2	JDP2_HUMAN	Jun dimerization protein 2	35						nucleus	sequence-specific DNA binding			lung(2)	2				BRCA - Breast invasive adenocarcinoma(234;0.0296)		GTGGAGGAGCTGAAATACGCT	0.642000													5	15					0	0	1	0	0
GFPT2	9945	broad.mit.edu	37	5	179765522	179765522	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA56-01A-31D-A391-08	TCGA-ZF-AA56-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85d9812c-68d6-4bdf-8674-bccf1eb0c8a8	26bda3c7-7369-4096-8905-08248b5bb9f1	g.chr5:179765522C>T	ENST00000253778.8	-	2	255	c.86G>A	c.(85-87)cGg>cAg	p.R29Q		NM_005110.2	NP_005101.1	O94808	GFPT2_HUMAN	glutamine-fructose-6-phosphate transaminase 2	29	Glutamine amidotransferase type-2.				dolichol-linked oligosaccharide biosynthetic process|energy reserve metabolic process|fructose 6-phosphate metabolic process|glutamine metabolic process|post-translational protein modification|protein N-linked glycosylation via asparagine|UDP-N-acetylglucosamine biosynthetic process	cytosol	glutamine-fructose-6-phosphate transaminase (isomerizing) activity|sugar binding			breast(1)|central_nervous_system(2)|kidney(2)|large_intestine(9)|lung(12)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	34	all_cancers(89;4.97e-05)|all_epithelial(37;1.22e-05)|Renal(175;0.000269)|Lung NSC(126;0.00199)|all_lung(126;0.00351)|Breast(19;0.137)	Medulloblastoma(196;0.0392)|all_neural(177;0.0529)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)		L-Glutamine(DB00130)	GTACTCCAGCCGCTGCAGGCC	0.597000													3	10					0	0	1	0	0
DYRK4	8798	broad.mit.edu	37	12	4722802	4722802	+	Silent	SNP	G	G	A			TCGA-ZF-AA56-01A-31D-A391-08	TCGA-ZF-AA56-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85d9812c-68d6-4bdf-8674-bccf1eb0c8a8	26bda3c7-7369-4096-8905-08248b5bb9f1	g.chr12:4722802G>A	ENST00000540757.2	+	13	1606	c.1446G>A	c.(1444-1446)ctG>ctA	p.L482L	DYRK4_ENST00000010132.5_Silent_p.L482L|DYRK4_ENST00000545342.1_Silent_p.L119L|DYRK4_ENST00000543431.1_Silent_p.L481L|RP11-500M8.7_ENST00000536588.1_Intron	NM_001282285.1|NM_001282286.1|NM_003845.1	NP_001269214.1|NP_001269215.1|NP_003836.1	Q9NR20	DYRK4_HUMAN	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4	482						Golgi apparatus	ATP binding|metal ion binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(8)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	27			Colorectal(7;0.103)			TGCCTCAACTGGTAGACGCTC	0.532000													6	27					0	0	1	0	0
ARPP21	10777	broad.mit.edu	37	3	35723250	35723250	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA56-01A-31D-A391-08	TCGA-ZF-AA56-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85d9812c-68d6-4bdf-8674-bccf1eb0c8a8	26bda3c7-7369-4096-8905-08248b5bb9f1	g.chr3:35723250G>C	ENST00000187397.4	+	3	463	c.7G>C	c.(7-9)Gag>Cag	p.E3Q	ARPP21_ENST00000337271.5_Missense_Mutation_p.E3Q|ARPP21_ENST00000417925.1_Missense_Mutation_p.E3Q|ARPP21_ENST00000436702.1_Missense_Mutation_p.E3Q|ARPP21_ENST00000427542.1_Missense_Mutation_p.E3Q|ARPP21_ENST00000432682.1_Missense_Mutation_p.E3Q|ARPP21_ENST00000396481.2_Missense_Mutation_p.E3Q|ARPP21_ENST00000396482.2_Missense_Mutation_p.E3Q|ARPP21_ENST00000444190.1_Missense_Mutation_p.E3Q|ARPP21_ENST00000458225.1_Missense_Mutation_p.E3Q|ARPP21_ENST00000428373.1_Missense_Mutation_p.E3Q|ARPP21_ENST00000438071.1_Missense_Mutation_p.E3Q|ARPP21_ENST00000412048.1_Missense_Mutation_p.E3Q|ARPP21_ENST00000474696.1_Missense_Mutation_p.E3Q|ARPP21_ENST00000441454.1_Missense_Mutation_p.E3Q	NM_016300.4	NP_057384.2	Q9UBL0	ARP21_HUMAN	cAMP-regulated phosphoprotein, 21kDa	3						cytoplasm	nucleic acid binding			cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(31)|ovary(3)|prostate(4)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	61						GAGAATGTCTGAGCAAGGAGA	0.413000													5	16					0	0	1	0	0
KIAA1033	23325	broad.mit.edu	37	12	105553894	105553894	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-AA56-01A-31D-A391-08	TCGA-ZF-AA56-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85d9812c-68d6-4bdf-8674-bccf1eb0c8a8	26bda3c7-7369-4096-8905-08248b5bb9f1	g.chr12:105553894C>A	ENST00000332180.5	+	29	3115	c.3028C>A	c.(3028-3030)Ctc>Atc	p.L1010I		NM_015275.1	NP_056090.1	Q2M389	WAHS7_HUMAN	KIAA1033	1010					endosome transport	WASH complex				breast(3)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(8)|lung(15)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	41						GAATATACATCTCCGAAATTT	0.358000													15	122					2.31682e-05	2.38398e-05	1	1	0
ATAD2	29028	broad.mit.edu	37	8	124351680	124351680	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA56-01A-31D-A391-08	TCGA-ZF-AA56-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85d9812c-68d6-4bdf-8674-bccf1eb0c8a8	26bda3c7-7369-4096-8905-08248b5bb9f1	g.chr8:124351680C>T	ENST00000287394.5	-	20	2832	c.2725G>A	c.(2725-2727)Gaa>Aaa	p.E909K	ATAD2_ENST00000521903.1_Missense_Mutation_p.E227K	NM_014109.3	NP_054828.2	Q6PL18	ATAD2_HUMAN	ATPase family, AAA domain containing 2	909					regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrion|nucleus	ATP binding|ATPase activity			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(12)|lung(16)|ovary(3)|prostate(3)|skin(1)|urinary_tract(2)	48	Lung NSC(37;1.25e-09)|Ovarian(258;0.00838)		STAD - Stomach adenocarcinoma(47;0.00288)			ATAAACAATTCTTGCACCTTA	0.299000													18	60					0	0	1	0	0
ZNF14	7561	broad.mit.edu	37	19	19823533	19823533	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA56-01A-31D-A391-08	TCGA-ZF-AA56-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85d9812c-68d6-4bdf-8674-bccf1eb0c8a8	26bda3c7-7369-4096-8905-08248b5bb9f1	g.chr19:19823533C>G	ENST00000344099.3	-	4	695	c.557G>C	c.(556-558)aGa>aCa	p.R186T		NM_021030.2	NP_066358.2	P17017	ZNF14_HUMAN	zinc finger protein 14	186					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|cervix(2)|endometrium(1)|large_intestine(9)|lung(8)|ovary(4)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)	32		Renal(1328;0.0474)				CCTTTCATGTCTTTGAAATGG	0.388000													14	62					0	0	1	0	0
ANXA2	302	broad.mit.edu	37	15	60648136	60648136	+	Silent	SNP	C	C	T			TCGA-ZF-AA56-01A-31D-A391-08	TCGA-ZF-AA56-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85d9812c-68d6-4bdf-8674-bccf1eb0c8a8	26bda3c7-7369-4096-8905-08248b5bb9f1	g.chr15:60648136C>T	ENST00000396024.3	-	8	669	c.510G>A	c.(508-510)ctG>ctA	p.L170L	ANXA2_ENST00000421017.2_Silent_p.L170L|ANXA2_ENST00000332680.4_Silent_p.L188L|ANXA2_ENST00000451270.2_Silent_p.L170L	NM_001136015.2	NP_001129487.1	P07355	ANXA2_HUMAN	annexin A2	170					angiogenesis|positive regulation of vesicle fusion|skeletal system development	basement membrane|melanosome|midbody|soluble fraction	calcium ion binding|calcium-dependent phospholipid binding|cytoskeletal protein binding|phospholipase inhibitor activity			kidney(1)|large_intestine(2)|lung(3)|ovary(2)|prostate(1)	9					Alteplase(DB00009)|Anistreplase(DB00029)|Tenecteplase(DB00031)	GGGCAACCATCAGCTTGCGGA	0.443000													12	56					0	0	1	0	0
THBS4	7060	broad.mit.edu	37	5	79374960	79374960	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA56-01A-31D-A391-08	TCGA-ZF-AA56-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85d9812c-68d6-4bdf-8674-bccf1eb0c8a8	26bda3c7-7369-4096-8905-08248b5bb9f1	g.chr5:79374960G>A	ENST00000350881.2	+	19	2580	c.2390G>A	c.(2389-2391)gGc>gAc	p.G797D	CTD-2201I18.1_ENST00000503007.1_RNA|CTD-2201I18.1_ENST00000514042.1_RNA|THBS4_ENST00000504720.1_3'UTR|THBS4_ENST00000511733.1_Missense_Mutation_p.G706D	NM_003248.4	NP_003239.2	P35443	TSP4_HUMAN	thrombospondin 4	797	TSP C-terminal.				endothelial cell-cell adhesion|myoblast migration|negative regulation of angiogenesis|positive regulation of endothelial cell proliferation|positive regulation of neutrophil chemotaxis|positive regulation of peptidyl-tyrosine phosphorylation	basement membrane|extracellular space	calcium ion binding|heparin binding|integrin binding|structural molecule activity			breast(1)|endometrium(4)|kidney(2)|large_intestine(9)|lung(14)|ovary(1)|stomach(3)	34		Lung NSC(167;0.00328)|all_lung(232;0.00355)|Ovarian(174;0.0261)		OV - Ovarian serous cystadenocarcinoma(54;6.3e-45)|Epithelial(54;1.77e-39)|all cancers(79;3.2e-34)		GACTATGCAGGCTTTATCTTT	0.478000													21	45					0	0	1	0	0
F9	2158	broad.mit.edu	37	X	138612941	138612941	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA56-01A-31D-A391-08	TCGA-ZF-AA56-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85d9812c-68d6-4bdf-8674-bccf1eb0c8a8	26bda3c7-7369-4096-8905-08248b5bb9f1	g.chrX:138612941G>A	ENST00000218099.2	+	1	25	c.18G>A	c.(16-18)atG>atA	p.M6I	F9_ENST00000394090.2_Missense_Mutation_p.M6I|F9_ENST00000479617.2_3'UTR	NM_000133.3	NP_000124.1	P00740	FA9_HUMAN	coagulation factor IX	6					blood coagulation, extrinsic pathway|blood coagulation, intrinsic pathway|peptidyl-glutamic acid carboxylation|post-translational protein modification|proteolysis	endoplasmic reticulum lumen|extracellular region|Golgi lumen|plasma membrane	calcium ion binding|serine-type endopeptidase activity			breast(1)|central_nervous_system(2)|endometrium(4)|large_intestine(7)|lung(19)|ovary(1)|skin(1)	35	Acute lymphoblastic leukemia(192;0.000127)				Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Heparin(DB01109)|Menadione(DB00170)	GCGTGAACATGATCATGGCAG	0.408000													15	71					0	0	1	0	0
PITPNM3	83394	broad.mit.edu	37	17	6387578	6387578	+	Silent	SNP	C	C	T			TCGA-ZF-AA56-01A-31D-A391-08	TCGA-ZF-AA56-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85d9812c-68d6-4bdf-8674-bccf1eb0c8a8	26bda3c7-7369-4096-8905-08248b5bb9f1	g.chr17:6387578C>T	ENST00000262483.8	-	5	396	c.309G>A	c.(307-309)agG>agA	p.R103R	PITPNM3_ENST00000421306.3_Silent_p.R67R	NM_031220.3	NP_112497.2	Q9BZ71	PITM3_HUMAN	PITPNM family member 3						phosphatidylinositol metabolic process	endomembrane system|integral to membrane	calcium ion binding|lipid binding|phosphatidylinositol transporter activity|receptor tyrosine kinase binding			autonomic_ganglia(1)|central_nervous_system(2)|endometrium(4)|kidney(2)|large_intestine(9)|lung(10)|ovary(3)|prostate(3)|skin(2)	36				Colorectal(2;0.000372)|READ - Rectum adenocarcinoma(2;0.0276)|LUAD - Lung adenocarcinoma(2;0.0836)|COAD - Colon adenocarcinoma(228;0.185)		GGGCTGGGAACCTCTGTCTTC	0.577000													6	94					0	0	1	0	0
NRM	11270	broad.mit.edu	37	6	30657885	30657885	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA56-01A-31D-A391-08	TCGA-ZF-AA56-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85d9812c-68d6-4bdf-8674-bccf1eb0c8a8	26bda3c7-7369-4096-8905-08248b5bb9f1	g.chr6:30657885G>A	ENST00000259953.4	-	3	620	c.269C>T	c.(268-270)tCc>tTc	p.S90F	NRM_ENST00000376420.5_Missense_Mutation_p.S90F|NRM_ENST00000376421.5_Missense_Mutation_p.S90F|NRM_ENST00000470733.1_5'UTR	NM_007243.2	NP_009174.1	Q8IXM6	NRM_HUMAN	nurim (nuclear envelope membrane protein)	90						integral to membrane|nuclear inner membrane				large_intestine(1)|lung(2)	3						AAAGTACCGGGATGTCCATGC	0.587000													10	82					0	0	1	0	0
MDN1	23195	broad.mit.edu	37	6	90458947	90458947	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-AA56-01A-31D-A391-08	TCGA-ZF-AA56-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85d9812c-68d6-4bdf-8674-bccf1eb0c8a8	26bda3c7-7369-4096-8905-08248b5bb9f1	g.chr6:90458947G>T	ENST00000369393.3	-	26	3872	c.3757C>A	c.(3757-3759)Ctt>Att	p.L1253I	MDN1_ENST00000428876.1_Missense_Mutation_p.L1253I			Q9NU22	MDN1_HUMAN	MDN1, midasin homolog (yeast)	1253					protein complex assembly|regulation of protein complex assembly	nucleus	ATP binding|ATPase activity|unfolded protein binding			NS(1)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(22)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(52)|liver(1)|lung(83)|ovary(10)|pancreas(1)|prostate(10)|skin(6)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	218		all_cancers(76;1.47e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00246)		BRCA - Breast invasive adenocarcinoma(108;0.0193)		AGTACCTGAAGATCCAGCATG	0.378000													14	35					1.3612e-06	1.45331e-06	1	1	0
ZNF132	7691	broad.mit.edu	37	19	58945495	58945495	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA56-01A-31D-A391-08	TCGA-ZF-AA56-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85d9812c-68d6-4bdf-8674-bccf1eb0c8a8	26bda3c7-7369-4096-8905-08248b5bb9f1	g.chr19:58945495G>C	ENST00000254166.3	-	3	1716	c.1316C>G	c.(1315-1317)gCt>gGt	p.A439G		NM_003433.3	NP_003424.3	P52740	ZN132_HUMAN	zinc finger protein 132	439						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(2)|endometrium(2)|kidney(2)|large_intestine(6)|lung(1)|ovary(2)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	19		all_cancers(17;4.4e-22)|all_epithelial(17;2.15e-16)|Lung NSC(17;1.24e-06)|all_lung(17;5.41e-06)|Colorectal(82;3.46e-05)|Renal(17;0.00179)|all_neural(62;0.00607)|Ovarian(87;0.0443)|Breast(46;0.0928)|Medulloblastoma(540;0.184)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0171)|Lung(386;0.182)		ATTGTTAAAAGCTCTTCCACA	0.473000													11	88					0	0	1	0	0
AGO1	26523	broad.mit.edu	37	1	36372659	36372659	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA56-01A-31D-A391-08	TCGA-ZF-AA56-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85d9812c-68d6-4bdf-8674-bccf1eb0c8a8	26bda3c7-7369-4096-8905-08248b5bb9f1	g.chr1:36372659G>C	ENST00000373204.4	+	12	1734	c.1521G>C	c.(1519-1521)aaG>aaC	p.K507N	AGO1_ENST00000373206.1_Missense_Mutation_p.K432N	NM_012199.2	NP_036331.1			argonaute RISC catalytic component 1																		GGCATCTCAAGAACACCTACT	0.517000													11	48					0	0	1	0	0
SEMA3E	9723	broad.mit.edu	37	7	83023647	83023647	+	Missense_Mutation	SNP	A	A	T			TCGA-ZF-AA56-01A-31D-A391-08	TCGA-ZF-AA56-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85d9812c-68d6-4bdf-8674-bccf1eb0c8a8	26bda3c7-7369-4096-8905-08248b5bb9f1	g.chr7:83023647A>T	ENST00000307792.3	-	13	1933	c.1466T>A	c.(1465-1467)gTt>gAt	p.V489D	SEMA3E_ENST00000427262.1_Missense_Mutation_p.V429D	NM_012431.2	NP_036563.1	O15041	SEM3E_HUMAN	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E	489	Sema.				axon guidance	extracellular space|membrane	receptor activity			breast(1)|endometrium(3)|kidney(4)|large_intestine(12)|liver(1)|lung(19)|ovary(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(3)	51		Medulloblastoma(109;0.109)				AATAATAGGAACTGGATCCTG	0.318000													16	21					0	0	1	0	0
CCL2	6347	broad.mit.edu	37	17	32583295	32583295	+	Nonsense_Mutation	SNP	C	C	G			TCGA-ZF-AA56-01A-31D-A391-08	TCGA-ZF-AA56-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85d9812c-68d6-4bdf-8674-bccf1eb0c8a8	26bda3c7-7369-4096-8905-08248b5bb9f1	g.chr17:32583295C>G	ENST00000225831.4	+	2	196	c.131C>G	c.(130-132)tCa>tGa	p.S44*	CCL2_ENST00000580907.1_Nonsense_Mutation_p.S44*	NM_002982.3	NP_002973.1	P13500	CCL2_HUMAN	chemokine (C-C motif) ligand 2	44					angiogenesis|anti-apoptosis|apoptotic cell clearance|astrocyte cell migration|cell adhesion|cellular response to interferon-gamma|cellular response to interleukin-1|cellular response to lipopolysaccharide|cellular response to tumor necrosis factor|G-protein signaling, coupled to cyclic nucleotide second messenger|helper T cell extravasation|humoral immune response|inflammatory response|JAK-STAT cascade|macrophage chemotaxis|monocyte chemotaxis|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of T cell activation|viral genome replication	extracellular space	CCR2 chemokine receptor binding|chemokine activity|protein kinase activity|signal transducer activity			kidney(1)|lung(3)|pancreas(1)|upper_aerodigestive_tract(1)	6	Breast(3;0.00224)	Ovarian(249;0.0694)|Breast(31;0.151)|Lung NSC(157;0.153)		UCEC - Uterine corpus endometrioid carcinoma (308;0.000241)|BRCA - Breast invasive adenocarcinoma(366;0.0103)	Atorvastatin(DB01076)|Danazol(DB01406)|Mimosine(DB01055)|Simvastatin(DB00641)	AGGAAGATCTCAGTGCAGAGG	0.453000													21	81					0	0	1	0	0
SETD2	29072	broad.mit.edu	37	3	47098490	47098490	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA56-01A-31D-A391-08	TCGA-ZF-AA56-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85d9812c-68d6-4bdf-8674-bccf1eb0c8a8	26bda3c7-7369-4096-8905-08248b5bb9f1	g.chr3:47098490G>A	ENST00000409792.3	-	15	6826	c.6784C>T	c.(6784-6786)Ccc>Tcc	p.P2262S		NM_014159.6	NP_054878.5	Q9BYW2	SETD2_HUMAN	SET domain containing 2	2262	Low charge region.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	DNA binding|histone-lysine N-methyltransferase activity|oxidoreductase activity|transition metal ion binding			breast(6)|central_nervous_system(5)|endometrium(4)|kidney(63)|large_intestine(18)|lung(26)|ovary(6)|prostate(2)|skin(3)|soft_tissue(1)|stomach(2)|urinary_tract(5)	141		Acute lymphoblastic leukemia(5;0.0169)		BRCA - Breast invasive adenocarcinoma(193;0.000302)|KIRC - Kidney renal clear cell carcinoma(197;0.00732)|Kidney(197;0.00844)		ACTGGGCCGGGGGCCGGCACT	0.532000			"""N, F, S, Mis"""		clear cell renal carcinoma								15	36					0	0	1	0	0
SGK1	6446	broad.mit.edu	37	6	134583106	134583106	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA56-01A-31D-A391-08	TCGA-ZF-AA56-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85d9812c-68d6-4bdf-8674-bccf1eb0c8a8	26bda3c7-7369-4096-8905-08248b5bb9f1	g.chr6:134583106C>G	ENST00000367858.5	-	2	847	c.250G>C	c.(250-252)Gag>Cag	p.E84Q	SGK1_ENST00000524929.1_Missense_Mutation_p.E84Q	NM_001143676.1	NP_001137148.1	O00141	SGK1_HUMAN	serum/glucocorticoid regulated kinase 1	0					apoptosis|response to stress|sodium ion transport	endoplasmic reticulum|nucleus|plasma membrane	ATP binding|protein binding|protein serine/threonine kinase activity			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(21)|kidney(3)|large_intestine(3)|lung(10)|ovary(1)|skin(4)|stomach(1)	46	Colorectal(23;0.221)			OV - Ovarian serous cystadenocarcinoma(155;0.00317)|GBM - Glioblastoma multiforme(68;0.00847)		GAACATGACTCGTTCTCCTGA	0.478000													22	89					0	0	1	0	0
MAP3K9	4293	broad.mit.edu	37	14	71209224	71209224	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA56-01A-31D-A391-08	TCGA-ZF-AA56-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85d9812c-68d6-4bdf-8674-bccf1eb0c8a8	26bda3c7-7369-4096-8905-08248b5bb9f1	g.chr14:71209224C>G	ENST00000554752.2	-	6	1410	c.1411G>C	c.(1411-1413)Gag>Cag	p.E471Q	MAP3K9_ENST00000555993.2_Missense_Mutation_p.E471Q|MAP3K9_ENST00000554146.1_Missense_Mutation_p.E208Q|MAP3K9_ENST00000381250.4_Missense_Mutation_p.E471Q|MAP3K9_ENST00000553414.1_Missense_Mutation_p.E165Q	NM_001284230.1	NP_001271159.1	P80192	M3K9_HUMAN	mitogen-activated protein kinase kinase kinase 9	471	Leucine-zipper 2.				activation of JUN kinase activity|protein autophosphorylation		ATP binding|JUN kinase kinase kinase activity|MAP kinase kinase activity|protein homodimerization activity			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(25)|ovary(2)|prostate(1)|skin(3)|stomach(2)	46				all cancers(60;0.00779)|BRCA - Breast invasive adenocarcinoma(234;0.00884)|OV - Ovarian serous cystadenocarcinoma(108;0.08)		TCGGCCAGCTCCTGCTCCCGA	0.622000													12	34					0	0	1	0	0
F13B	2165	broad.mit.edu	37	1	197031988	197031988	+	Splice_Site	SNP	G	G	A			TCGA-ZF-AA56-01A-31D-A391-08	TCGA-ZF-AA56-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85d9812c-68d6-4bdf-8674-bccf1eb0c8a8	26bda3c7-7369-4096-8905-08248b5bb9f1	g.chr1:197031988G>A	ENST00000367412.1	-	2	307	c.264C>T	c.(262-264)ttC>ttT	p.F88F		NM_001994.2	NP_001985.2	P05160	F13B_HUMAN	coagulation factor XIII, B polypeptide	88	Sushi 1.				blood coagulation	extracellular region				breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(5)|liver(1)|lung(40)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)	66						CTGACTTACTGAAGCACCTTG	0.393000													18	126					0	0	1	0	0
B4GALNT2	124872	broad.mit.edu	37	17	47241497	47241497	+	Missense_Mutation	SNP	C	C	T	rs145043273		TCGA-ZF-AA56-01A-31D-A391-08	TCGA-ZF-AA56-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85d9812c-68d6-4bdf-8674-bccf1eb0c8a8	26bda3c7-7369-4096-8905-08248b5bb9f1	g.chr17:47241497C>T	ENST00000300404.2	+	8	1053	c.994C>T	c.(994-996)Cgc>Tgc	p.R332C	B4GALNT2_ENST00000393354.2_Missense_Mutation_p.R272C|B4GALNT2_ENST00000504681.1_Missense_Mutation_p.R246C	NM_153446.2	NP_703147.2	Q8NHY0	B4GN2_HUMAN	beta-1,4-N-acetyl-galactosaminyl transferase 2	332					lipid glycosylation|negative regulation of cell-cell adhesion|UDP-N-acetylgalactosamine metabolic process	integral to Golgi membrane	acetylgalactosaminyltransferase activity			endometrium(3)|large_intestine(6)|liver(2)|lung(8)|ovary(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	24			all cancers(6;0.000316)			GACTTTCCTCCGCCCCCACAA	0.502000													65	69					0	0	1	0	0
SECISBP2L	9728	broad.mit.edu	37	15	49325231	49325231	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA56-01A-31D-A391-08	TCGA-ZF-AA56-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85d9812c-68d6-4bdf-8674-bccf1eb0c8a8	26bda3c7-7369-4096-8905-08248b5bb9f1	g.chr15:49325231C>G	ENST00000559471.1	-	4	858	c.595G>C	c.(595-597)Gaa>Caa	p.E199Q	SECISBP2L_ENST00000261847.3_Missense_Mutation_p.E199Q	NM_001193489.1	NP_001180418.1	Q93073	SBP2L_HUMAN	SECIS binding protein 2-like	199										breast(1)|endometrium(5)|kidney(8)|large_intestine(12)|lung(11)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|urinary_tract(1)	46						GCATTTGTTTCTTTCTGAGTA	0.378000													5	116					0	0	1	0	0
IQCC	55721	broad.mit.edu	37	1	32671293	32671293	+	Missense_Mutation	SNP	A	A	T			TCGA-ZF-AA56-01A-31D-A391-08	TCGA-ZF-AA56-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85d9812c-68d6-4bdf-8674-bccf1eb0c8a8	26bda3c7-7369-4096-8905-08248b5bb9f1	g.chr1:32671293A>T	ENST00000537469.1	+	1	58	c.11A>T	c.(10-12)gAg>gTg	p.E4V	IQCC_ENST00000291358.6_Missense_Mutation_p.E4V|RP4-622L5.7_ENST00000421616.1_RNA|RP4-622L5.7_ENST00000373604.4_RNA	NM_001160042.1	NP_001153514.1	Q4KMZ1	IQCC_HUMAN	IQ motif containing C	4										endometrium(4)|large_intestine(1)|lung(3)|ovary(4)|skin(2)|urinary_tract(1)	15		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.186)				ATGGAGCCAGAGCTGCTGGTT	0.657000													4	8					0	0	1	0	0
GLS	2744	broad.mit.edu	37	2	191760340	191760340	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA56-01A-31D-A391-08	TCGA-ZF-AA56-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85d9812c-68d6-4bdf-8674-bccf1eb0c8a8	26bda3c7-7369-4096-8905-08248b5bb9f1	g.chr2:191760340C>G	ENST00000320717.3	+	3	752	c.494C>G	c.(493-495)tCt>tGt	p.S165C	GLS_ENST00000338435.4_Missense_Mutation_p.S165C	NM_014905.4	NP_055720.3	O94925	GLSK_HUMAN	glutaminase	165					cellular amino acid biosynthetic process|glutamate secretion|glutamine catabolic process|neurotransmitter secretion	mitochondrial matrix	glutaminase activity			breast(1)|cervix(1)|endometrium(1)|kidney(1)|lung(9)|ovary(1)|skin(1)|urinary_tract(1)	16			OV - Ovarian serous cystadenocarcinoma(117;0.00625)|Epithelial(96;0.0744)|all cancers(119;0.181)		L-Glutamic Acid(DB00142)|L-Glutamine(DB00130)	GCACTCAAATCTACAGGATTG	0.308000													22	60					0	0	1	0	0
HIST1H2BB	3018	broad.mit.edu	37	6	26043873	26043873	+	Missense_Mutation	SNP	A	A	T			TCGA-ZF-AA56-01A-31D-A391-08	TCGA-ZF-AA56-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85d9812c-68d6-4bdf-8674-bccf1eb0c8a8	26bda3c7-7369-4096-8905-08248b5bb9f1	g.chr6:26043873A>T	ENST00000357905.2	-	1	12	c.13T>A	c.(13-15)Tct>Act	p.S5T		NM_021062.2	NP_066406.1	P33778	H2B1B_HUMAN	histone cluster 1, H2bb	5					nucleosome assembly	nucleosome|nucleus	DNA binding			endometrium(1)|kidney(1)|large_intestine(2)|lung(3)	7						GCAGACTTAGAGGGTTCAGGC	0.453000													8	39					0	0	1	0	0
C3	718	broad.mit.edu	37	19	6719303	6719303	+	Silent	SNP	G	G	A			TCGA-ZF-AA56-01A-31D-A391-08	TCGA-ZF-AA56-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85d9812c-68d6-4bdf-8674-bccf1eb0c8a8	26bda3c7-7369-4096-8905-08248b5bb9f1	g.chr19:6719303G>A	ENST00000245907.6	-	2	278	c.186C>T	c.(184-186)ttC>ttT	p.F62F		NM_000064.2	NP_000055.2	P01024	CO3_HUMAN	complement component 3	62					complement activation, alternative pathway|complement activation, classical pathway|G-protein coupled receptor protein signaling pathway|inflammatory response|positive regulation vascular endothelial growth factor production	extracellular space	endopeptidase inhibitor activity|receptor binding			breast(5)|endometrium(7)|kidney(6)|large_intestine(18)|liver(1)|lung(18)|ovary(1)|pancreas(1)|prostate(5)|skin(7)|upper_aerodigestive_tract(3)	72				GBM - Glioblastoma multiforme(1328;1.36e-05)|Lung(535;0.00661)		TTTTGCCTGGGAAGTCGTGGA	0.587000													8	74					0	0	1	0	0
SPARCL1	8404	broad.mit.edu	37	4	88400731	88400731	+	Splice_Site	SNP	C	C	G			TCGA-ZF-AA56-01A-31D-A391-08	TCGA-ZF-AA56-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85d9812c-68d6-4bdf-8674-bccf1eb0c8a8	26bda3c7-7369-4096-8905-08248b5bb9f1	g.chr4:88400731C>G	ENST00000418378.1	-	11	2389		c.e11-1		SPARCL1_ENST00000282470.6_Splice_Site|SPARCL1_ENST00000503414.1_Splice_Site	NM_001128310.1	NP_001121782.1	Q14515	SPRL1_HUMAN	SPARC-like 1 (hevin)						signal transduction	extracellular space|proteinaceous extracellular matrix	calcium ion binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(7)|ovary(1)|skin(2)|stomach(2)	21				OV - Ovarian serous cystadenocarcinoma(123;0.00118)		TGTCAAGACTCTGCAATGAAA	0.448000													8	39					0	0	1	0	0
ADRA1B	147	broad.mit.edu	37	5	159344797	159344797	+	Silent	SNP	G	G	A	rs149628499		TCGA-ZF-AA56-01A-31D-A391-08	TCGA-ZF-AA56-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85d9812c-68d6-4bdf-8674-bccf1eb0c8a8	26bda3c7-7369-4096-8905-08248b5bb9f1	g.chr5:159344797G>A	ENST00000306675.3	+	1	1008	c.885G>A	c.(883-885)acG>acA	p.T295T		NM_000679.3	NP_000670.1	P35368	ADA1B_HUMAN	adrenoceptor alpha 1B	295					cell proliferation|cell-cell signaling|G-protein signaling, coupled to cAMP nucleotide second messenger|intracellular protein kinase cascade	integral to plasma membrane	alpha1-adrenergic receptor activity			endometrium(3)|large_intestine(6)|lung(7)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	19	Renal(175;0.00196)	Medulloblastoma(196;0.0354)|all_neural(177;0.138)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)		Alfuzosin(DB00346)|Bethanidine(DB00217)|Dapiprazole(DB00298)|Debrisoquin(DB04840)|Dextroamphetamine(DB01576)|Doxazosin(DB00590)|Guanadrel Sulfate(DB00226)|Guanethidine(DB01170)|Guanfacine(DB01018)|Labetalol(DB00598)|Lisdexamfetamine(DB01255)|Methamphetamine(DB01577)|Methotrimeprazine(DB01403)|Methoxamine(DB00723)|Midodrine(DB00211)|Modafinil(DB00745)|Nefazodone(DB01149)|Norepinephrine(DB00368)|Olanzapine(DB00334)|Phendimetrazine(DB01579)|Phenylephrine(DB00388)|Prazosin(DB00457)|Promazine(DB00420)|Propericiazine(DB01608)|Propiomazine(DB00777)|Quetiapine(DB01224)|Risperidone(DB00734)|Sertindole(DB06144)|Tamsulosin(DB00706)|Terazosin(DB01162)|Trazodone(DB00656)	CAGCTAAGACGTTGGGCATTG	0.517000													4	135					0	0	1	0	0
PARD3B	117583	broad.mit.edu	37	2	206166544	206166544	+	Silent	SNP	C	C	T			TCGA-ZF-AA56-01A-31D-A391-08	TCGA-ZF-AA56-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85d9812c-68d6-4bdf-8674-bccf1eb0c8a8	26bda3c7-7369-4096-8905-08248b5bb9f1	g.chr2:206166544C>T	ENST00000462231.1	+	19	2881	c.2721C>T	c.(2719-2721)taC>taT	p.Y907Y	PARD3B_ENST00000351153.1_Intron|PARD3B_ENST00000349953.3_Intron|PARD3B_ENST00000406610.2_Intron|PARD3B_ENST00000358768.2_Intron			Q8TEW8	PAR3L_HUMAN	par-3 family cell polarity regulator beta	0					cell cycle|cell division	endomembrane system|tight junction				breast(1)|endometrium(9)|kidney(2)|large_intestine(6)|liver(4)|lung(33)|ovary(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)	65		all_cancers(1;2.88e-06)|all_epithelial(1;3.23e-06)		Epithelial(149;0.0739)		CAAATGCATACGGCTCTCAAT	0.443000													7	30					0	0	1	0	0
ZHX2	22882	broad.mit.edu	37	8	123965662	123965662	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA56-01A-31D-A391-08	TCGA-ZF-AA56-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85d9812c-68d6-4bdf-8674-bccf1eb0c8a8	26bda3c7-7369-4096-8905-08248b5bb9f1	g.chr8:123965662G>C	ENST00000314393.4	+	3	2747	c.1912G>C	c.(1912-1914)Gaa>Caa	p.E638Q		NM_014943.3	NP_055758.1	Q9Y6X8	ZHX2_HUMAN	zinc fingers and homeoboxes 2	638						cytoplasm|nucleus|plasma membrane	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(10)|lung(15)|ovary(1)|prostate(1)|skin(4)|stomach(3)|urinary_tract(1)	45	Lung NSC(37;2e-09)|Ovarian(258;0.0205)|Hepatocellular(40;0.105)		STAD - Stomach adenocarcinoma(47;0.00527)			AAAAAGTCAAGAACAGGTTCA	0.572000													14	63					0	0	1	0	0
CLIP2	7461	broad.mit.edu	37	7	73790609	73790609	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-AA56-01A-31D-A391-08	TCGA-ZF-AA56-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85d9812c-68d6-4bdf-8674-bccf1eb0c8a8	26bda3c7-7369-4096-8905-08248b5bb9f1	g.chr7:73790609G>T	ENST00000223398.6	+	10	2205	c.1878G>T	c.(1876-1878)aaG>aaT	p.K626N	CLIP2_ENST00000361545.5_Missense_Mutation_p.K591N|CLIP2_ENST00000395060.1_Missense_Mutation_p.K626N	NM_003388.4	NP_003379	Q9UDT6	CLIP2_HUMAN	CAP-GLY domain containing linker protein 2	626						microtubule associated complex				breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(13)|pancreas(1)|prostate(2)|skin(3)	30						ACCACCAGAAGTCCCTGGAGG	0.612000													7	27					0.0293803	0.0298001	1	1	0
WDFY3	23001	broad.mit.edu	37	4	85645714	85645714	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA56-01A-31D-A391-08	TCGA-ZF-AA56-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85d9812c-68d6-4bdf-8674-bccf1eb0c8a8	26bda3c7-7369-4096-8905-08248b5bb9f1	g.chr4:85645714C>G	ENST00000322366.6	-	45	7662	c.7255G>C	c.(7255-7257)Gac>Cac	p.D2419H	WDFY3_ENST00000295888.4_Missense_Mutation_p.D2436H			Q8IZQ1	WDFY3_HUMAN	WD repeat and FYVE domain containing 3	2436						cytoplasmic part|extrinsic to membrane|nuclear envelope	1-phosphatidylinositol binding|metal ion binding|protein binding			breast(5)|central_nervous_system(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(32)|lung(50)|ovary(3)|prostate(5)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	134		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000808)		TCTTTACTGTCATAACTTACG	0.428000													27	69					0	0	1	0	0
KAT2B	8850	broad.mit.edu	37	3	20161148	20161148	+	Silent	SNP	T	T	G			TCGA-ZF-AA56-01A-31D-A391-08	TCGA-ZF-AA56-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85d9812c-68d6-4bdf-8674-bccf1eb0c8a8	26bda3c7-7369-4096-8905-08248b5bb9f1	g.chr3:20161148T>G	ENST00000263754.4	+	8	1664	c.1209T>G	c.(1207-1209)ctT>ctG	p.L403L		NM_003884.4	NP_003875.3	Q92831	KAT2B_HUMAN	K(lysine) acetyltransferase 2B	403					cell cycle arrest|cellular response to insulin stimulus|chromatin remodeling|histone H3 acetylation|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|negative regulation of cell proliferation|transcription initiation from RNA polymerase I promoter	Ada2/Gcn5/Ada3 transcription activator complex|chromatin remodeling complex|PCAF complex	cyclin-dependent protein kinase inhibitor activity|histone acetyltransferase activity|histone deacetylase binding|protein kinase binding|transcription coactivator activity|transcription factor binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|lung(15)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(1)	40						CATCTTCCCTTGAGCAGCCAA	0.512000													19	30					0	0	1	0	0
SEMA4G	57715	broad.mit.edu	37	10	102740680	102740680	+	Silent	SNP	C	C	G			TCGA-ZF-AA56-01A-31D-A391-08	TCGA-ZF-AA56-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85d9812c-68d6-4bdf-8674-bccf1eb0c8a8	26bda3c7-7369-4096-8905-08248b5bb9f1	g.chr10:102740680C>G	ENST00000210633.3	+	12	1647	c.1569C>G	c.(1567-1569)ccC>ccG	p.P523P	MRPL43_ENST00000370241.3_Intron|MRPL43_ENST00000370242.4_Intron|RP11-108L7.4_ENST00000447344.1_RNA|SEMA4G_ENST00000517724.1_Silent_p.P523P|SEMA4G_ENST00000370250.4_Silent_p.P523P|MRPL43_ENST00000318325.2_Intron			Q9NTN9	SEM4G_HUMAN	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G	523	PSI.				cell differentiation|nervous system development	integral to membrane	receptor activity			breast(3)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(9)|lung(5)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	25		Colorectal(252;0.234)		Epithelial(162;3.71e-09)|all cancers(201;2.1e-07)		CCCGAGACCCCTACTGTGGCT	0.632000													22	127					0	0	1	0	0
PRDM2	7799	broad.mit.edu	37	1	14109091	14109091	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA56-01A-31D-A391-08	TCGA-ZF-AA56-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85d9812c-68d6-4bdf-8674-bccf1eb0c8a8	26bda3c7-7369-4096-8905-08248b5bb9f1	g.chr1:14109091G>A	ENST00000235372.7	+	8	5657	c.4801G>A	c.(4801-4803)Gct>Act	p.A1601T	PRDM2_ENST00000343137.4_Missense_Mutation_p.A1400T|PRDM2_ENST00000505823.1_Intron|PRDM2_ENST00000311066.5_Missense_Mutation_p.A1601T|PRDM2_ENST00000413440.1_Missense_Mutation_p.A1400T|PRDM2_ENST00000376048.5_Intron|PRDM2_ENST00000503842.1_Intron	NM_012231.4	NP_036363.2	Q13029	PRDM2_HUMAN	PR domain containing 2, with ZNF domain	1601						Golgi apparatus|nucleus	DNA binding|histone-lysine N-methyltransferase activity|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(16)|lung(20)|ovary(3)|prostate(3)|skin(1)|urinary_tract(2)	55	Ovarian(185;0.249)	all_lung(284;2.56e-05)|Lung NSC(185;4.94e-05)|Renal(390;0.000147)|Breast(348;0.000162)|Colorectal(325;0.00058)|Ovarian(437;0.00965)|Hepatocellular(190;0.0245)|Myeloproliferative disorder(586;0.0255)	GBM - Glioblastoma multiforme(2;0.00182)	UCEC - Uterine corpus endometrioid carcinoma (279;0.00224)|Colorectal(212;3.23e-08)|BRCA - Breast invasive adenocarcinoma(304;2.16e-05)|COAD - Colon adenocarcinoma(227;2.53e-05)|Kidney(185;0.000762)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(313;0.00446)|READ - Rectum adenocarcinoma(331;0.0276)|Lung(427;0.145)		GAATCATTCTGCTCAGCTTTC	0.453000													11	48					0	0	1	0	0
CYP2A13	1553	broad.mit.edu	37	19	41600885	41600885	+	Silent	SNP	C	C	T			TCGA-ZF-AA56-01A-31D-A391-08	TCGA-ZF-AA56-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85d9812c-68d6-4bdf-8674-bccf1eb0c8a8	26bda3c7-7369-4096-8905-08248b5bb9f1	g.chr19:41600885C>T	ENST00000330436.3	+	8	1183	c.1183C>T	c.(1183-1185)Ctg>Ttg	p.L395L		NM_000766.4	NP_000757.2	Q16696	CP2AD_HUMAN	cytochrome P450, family 2, subfamily A, polypeptide 13	395					xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|coumarin 7-hydroxylase activity|electron carrier activity|heme binding			breast(3)|endometrium(6)|kidney(4)|large_intestine(8)|lung(13)|ovary(3)|prostate(3)|skin(2)	42					Clomipramine(DB01242)|Nicotine(DB00184)	GTTCCCTATGCTGGGCTCCGT	0.572000													25	75					0	0	1	0	0
IL18RAP	8807	broad.mit.edu	37	2	103061773	103061773	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-AA56-01A-31D-A391-08	TCGA-ZF-AA56-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85d9812c-68d6-4bdf-8674-bccf1eb0c8a8	26bda3c7-7369-4096-8905-08248b5bb9f1	g.chr2:103061773T>C	ENST00000264260.2	+	9	1634	c.1045T>C	c.(1045-1047)Tcc>Ccc	p.S349P	IL18RAP_ENST00000409369.1_Missense_Mutation_p.S207P	NM_003853.2	NP_003844.1	O95256	I18RA_HUMAN	interleukin 18 receptor accessory protein	349	Ig-like C2-type 2.				cell surface receptor linked signaling pathway|inflammatory response|innate immune response	integral to membrane	transmembrane receptor activity			autonomic_ganglia(1)|central_nervous_system(2)|endometrium(3)|kidney(4)|large_intestine(5)|lung(10)|ovary(2)|prostate(1)|skin(5)|urinary_tract(4)	37						CACAACCCAGTCCGTCCAACT	0.448000													17	40					0	0	1	0	0
PPIP5K1	9677	broad.mit.edu	37	15	43827480	43827480	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA56-01A-31D-A391-08	TCGA-ZF-AA56-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85d9812c-68d6-4bdf-8674-bccf1eb0c8a8	26bda3c7-7369-4096-8905-08248b5bb9f1	g.chr15:43827480C>G	ENST00000420765.1	-	31	3876	c.3694G>C	c.(3694-3696)Gag>Cag	p.E1232Q	PPIP5K1_ENST00000381885.1_Missense_Mutation_p.E1228Q|PPIP5K1_ENST00000381879.4_Missense_Mutation_p.E1208Q|PPIP5K1_ENST00000334933.4_Missense_Mutation_p.E1207Q|PPIP5K1_ENST00000396923.3_Missense_Mutation_p.E1232Q|PPIP5K1_ENST00000360135.4_Missense_Mutation_p.E1205Q|PPIP5K1_ENST00000360301.4_Missense_Mutation_p.E1207Q|PPIP5K1_ENST00000348806.6_Missense_Mutation_p.E1205Q	NM_001130858.2	NP_001124330.1	Q6PFW1	VIP1_HUMAN	diphosphoinositol pentakisphosphate kinase 1	1232					inositol metabolic process	cytosol	acid phosphatase activity|ATP binding|diphosphoinositol-pentakisphosphate kinase activity|inositol 1,3,4,5,6-pentakisphosphate kinase activity|inositol hexakisphosphate 5-kinase activity			large_intestine(1)	1						TCAAAAAGCTCTTGCTCCCCT	0.557000													36	54					0	0	1	0	0
SPTA1	6708	broad.mit.edu	37	1	158639340	158639340	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA56-01A-31D-A391-08	TCGA-ZF-AA56-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85d9812c-68d6-4bdf-8674-bccf1eb0c8a8	26bda3c7-7369-4096-8905-08248b5bb9f1	g.chr1:158639340C>T	ENST00000368147.4	-	14	1871	c.1691G>A	c.(1690-1692)cGg>cAg	p.R564Q		NM_003126.2	NP_003117.2	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1 (elliptocytosis 2)						actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			NS(3)|breast(7)|cervix(1)|endometrium(22)|kidney(9)|large_intestine(29)|liver(2)|lung(183)|ovary(5)|prostate(18)|skin(11)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(6)	307	all_hematologic(112;0.0378)					TAGGGCATCCCGCCGGGCTAA	0.493000													14	89					0	0	1	0	0
WDR66	144406	broad.mit.edu	37	12	122437840	122437840	+	Silent	SNP	C	C	T			TCGA-ZF-AA56-01A-31D-A391-08	TCGA-ZF-AA56-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85d9812c-68d6-4bdf-8674-bccf1eb0c8a8	26bda3c7-7369-4096-8905-08248b5bb9f1	g.chr12:122437840C>T	ENST00000288912.4	+	20	4079	c.3225C>T	c.(3223-3225)ctC>ctT	p.L1075L		NM_144668.5	NP_653269.3	Q8TBY9	WDR66_HUMAN	WD repeat domain 66	1075							calcium ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(11)|liver(2)|lung(13)|ovary(2)|prostate(2)|skin(2)|soft_tissue(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	43	all_neural(191;0.0496)|Medulloblastoma(191;0.0922)			OV - Ovarian serous cystadenocarcinoma(86;0.000155)|Epithelial(86;0.000634)|BRCA - Breast invasive adenocarcinoma(302;0.248)		TGAGACTGCTCGTTACTAAAG	0.507000													9	45					0	0	1	0	0
HELZ	9931	broad.mit.edu	37	17	65191564	65191564	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA56-01A-31D-A391-08	TCGA-ZF-AA56-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85d9812c-68d6-4bdf-8674-bccf1eb0c8a8	26bda3c7-7369-4096-8905-08248b5bb9f1	g.chr17:65191564G>C	ENST00000358691.5	-	8	618	c.452C>G	c.(451-453)tCt>tGt	p.S151C	HELZ_ENST00000580168.1_Missense_Mutation_p.S151C|HELZ_ENST00000580662.1_Intron	NM_014877.3	NP_055692			helicase with zinc finger											NS(1)|breast(5)|endometrium(9)|kidney(3)|large_intestine(11)|liver(1)|lung(24)|ovary(1)|pancreas(1)|prostate(1)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(2)	69	all_cancers(12;1.24e-11)|Breast(2;1.05e-17)|all_epithelial(3;3.87e-13)					GTGATATCCAGAGAGGGCGTT	0.358000													4	93					0	0	1	0	0
PRX	57716	broad.mit.edu	37	19	40901723	40901723	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA56-01A-31D-A391-08	TCGA-ZF-AA56-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85d9812c-68d6-4bdf-8674-bccf1eb0c8a8	26bda3c7-7369-4096-8905-08248b5bb9f1	g.chr19:40901723G>A	ENST00000324001.7	-	7	2806	c.2536C>T	c.(2536-2538)Cat>Tat	p.H846Y	PRX_ENST00000291825.7_3'UTR	NM_181882.2	NP_870998.2	Q9BXM0	PRAX_HUMAN	periaxin	846					axon ensheathment	cytoplasm|nucleus|plasma membrane	protein binding			breast(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(7)|lung(12)|ovary(2)|prostate(3)|skin(1)|urinary_tract(9)	47			Lung(22;6.24e-05)|LUSC - Lung squamous cell carcinoma(20;0.000384)			ACACCCACATGAGCCTCACCA	0.622000													8	76					0	0	1	0	0
HUWE1	10075	broad.mit.edu	37	X	53620515	53620515	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA56-01A-31D-A391-08	TCGA-ZF-AA56-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85d9812c-68d6-4bdf-8674-bccf1eb0c8a8	26bda3c7-7369-4096-8905-08248b5bb9f1	g.chrX:53620515C>G	ENST00000342160.3	-	31	4007	c.3550G>C	c.(3550-3552)Gag>Cag	p.E1184Q	HUWE1_ENST00000218328.8_Missense_Mutation_p.E1184Q|HUWE1_ENST00000262854.6_Missense_Mutation_p.E1184Q			Q7Z6Z7	HUWE1_HUMAN	HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase	1184					base-excision repair|cell differentiation|histone ubiquitination|protein monoubiquitination|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	DNA binding|protein binding|ubiquitin-protein ligase activity			NS(1)|breast(15)|central_nervous_system(1)|cervix(1)|endometrium(17)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(29)|liver(2)|lung(52)|ovary(11)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(2)	153						TCCAATCCCTCAGAAACAGGA	0.453000													12	34					0	0	1	0	0
RBBP4	5928	broad.mit.edu	37	1	33134446	33134446	+	Silent	SNP	A	A	C			TCGA-ZF-AA56-01A-31D-A391-08	TCGA-ZF-AA56-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85d9812c-68d6-4bdf-8674-bccf1eb0c8a8	26bda3c7-7369-4096-8905-08248b5bb9f1	g.chr1:33134446A>C	ENST00000373493.5	+	5	750	c.591A>C	c.(589-591)tcA>tcC	p.S197S	RBBP4_ENST00000414241.3_Silent_p.S196S|RBBP4_ENST00000458695.2_Silent_p.S162S|RBBP4_ENST00000524393.1_3'UTR|RBBP4_ENST00000373485.1_Silent_p.S197S|RBBP4_ENST00000544435.1_5'UTR	NM_001135255.1|NM_005610.2	NP_001128727.1|NP_005601.1	Q09028	RBBP4_HUMAN	retinoblastoma binding protein 4	197					cell cycle|CenH3-containing nucleosome assembly at centromere|DNA replication|negative regulation of cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	CAF-1 complex|ESC/E(Z) complex|NuRD complex|NURF complex|Sin3 complex	histone binding|histone deacetylase binding			breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(4)|ovary(1)|prostate(4)|urinary_tract(1)	15		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)				TTAGTGCTTCAGATGACCATG	0.478000													17	49					0	0	1	0	0
MEP1A	4224	broad.mit.edu	37	6	46766363	46766363	+	Nonsense_Mutation	SNP	C	C	T			TCGA-ZF-AA56-01A-31D-A391-08	TCGA-ZF-AA56-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85d9812c-68d6-4bdf-8674-bccf1eb0c8a8	26bda3c7-7369-4096-8905-08248b5bb9f1	g.chr6:46766363C>T	ENST00000230588.4	+	4	175	c.166C>T	c.(166-168)Caa>Taa	p.Q56*		NM_005588.2	NP_005579.2	Q16819	MEP1A_HUMAN	meprin A, alpha (PABA peptide hydrolase)	56					digestion|proteolysis	extracellular space|integral to plasma membrane|soluble fraction	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(1)|endometrium(5)|kidney(2)|large_intestine(4)|lung(21)|ovary(1)|pancreas(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	42			Lung(136;0.192)			GGACCTCTTTCAAGGGGACAT	0.418000													20	73					0	0	1	0	0
MIIP	60672	broad.mit.edu	37	1	12089942	12089942	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA56-01A-31D-A391-08	TCGA-ZF-AA56-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85d9812c-68d6-4bdf-8674-bccf1eb0c8a8	26bda3c7-7369-4096-8905-08248b5bb9f1	g.chr1:12089942C>T	ENST00000235332.4	+	7	1005	c.836C>T	c.(835-837)gCg>gTg	p.A279V	MIIP_ENST00000436478.2_Missense_Mutation_p.A279V|MIIP_ENST00000466860.1_3'UTR	NM_021933.3	NP_068752.2	Q5JXC2	MIIP_HUMAN	migration and invasion inhibitory protein	279	Interaction with IGFBP2.									autonomic_ganglia(1)|kidney(1)|large_intestine(4)|lung(5)|ovary(1)|prostate(2)|skin(1)	15						GCGCAGCCAGCGCACGTCAGG	0.662000													3	24					0	0	1	0	0
PPIP5K1	9677	broad.mit.edu	37	15	43826919	43826919	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA56-01A-31D-A391-08	TCGA-ZF-AA56-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85d9812c-68d6-4bdf-8674-bccf1eb0c8a8	26bda3c7-7369-4096-8905-08248b5bb9f1	g.chr15:43826919C>T	ENST00000420765.1	-	31	4437	c.4255G>A	c.(4255-4257)Gag>Aag	p.E1419K	PPIP5K1_ENST00000381885.1_Missense_Mutation_p.E1415K|PPIP5K1_ENST00000381879.4_Missense_Mutation_p.E1395K|PPIP5K1_ENST00000334933.4_Missense_Mutation_p.E1394K|PPIP5K1_ENST00000396923.3_Missense_Mutation_p.E1419K|PPIP5K1_ENST00000360135.4_Missense_Mutation_p.E1392K|PPIP5K1_ENST00000360301.4_Missense_Mutation_p.E1394K|PPIP5K1_ENST00000348806.6_Missense_Mutation_p.E1392K	NM_001130858.2	NP_001124330.1	Q6PFW1	VIP1_HUMAN	diphosphoinositol pentakisphosphate kinase 1	1419					inositol metabolic process	cytosol	acid phosphatase activity|ATP binding|diphosphoinositol-pentakisphosphate kinase activity|inositol 1,3,4,5,6-pentakisphosphate kinase activity|inositol hexakisphosphate 5-kinase activity			large_intestine(1)	1						TCAATCTCCTCAGGGAACTCT	0.527000													57	106					0	0	1	0	0
ZNF311	282890	broad.mit.edu	37	6	28963251	28963251	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA56-01A-31D-A391-08	TCGA-ZF-AA56-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85d9812c-68d6-4bdf-8674-bccf1eb0c8a8	26bda3c7-7369-4096-8905-08248b5bb9f1	g.chr6:28963251C>G	ENST00000377179.3	-	7	2040	c.1528G>C	c.(1528-1530)Gat>Cat	p.D510H	ZNF311_ENST00000483450.1_5'UTR	NM_001010877.2	NP_001010877.2	Q5JNZ3	ZN311_HUMAN	zinc finger protein 311	510					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			NS(1)|breast(4)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(11)|skin(3)|upper_aerodigestive_tract(2)	28						CAGTGCTTATCTTGGAAGGTT	0.468000													11	68					0	0	1	0	0
KIAA0754	643314	broad.mit.edu	37	1	39878220	39878220	+	Silent	SNP	G	G	C			TCGA-ZF-AA56-01A-31D-A391-08	TCGA-ZF-AA56-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85d9812c-68d6-4bdf-8674-bccf1eb0c8a8	26bda3c7-7369-4096-8905-08248b5bb9f1	g.chr1:39878220G>C	ENST00000530275.1	+	1	2070	c.1875G>C	c.(1873-1875)ctG>ctC	p.L625L	MACF1_ENST00000361689.2_Intron|MACF1_ENST00000372915.3_Intron|MACF1_ENST00000567887.1_Intron|MACF1_ENST00000564288.1_Intron|MACF1_ENST00000539005.1_Intron|MACF1_ENST00000317713.7_Intron|MACF1_ENST00000545844.1_Intron|MACF1_ENST00000289893.4_Intron	NM_015038.1	NP_055853.1	O94854	K0754_HUMAN	KIAA0754	625										central_nervous_system(1)|large_intestine(6)|skin(1)	8	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0393)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			CAGAGATTCTGAGTCTGCACC	0.493000													7	57					0	0	1	0	0
ADAM21	8747	broad.mit.edu	37	14	70926021	70926021	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA56-01A-31D-A391-08	TCGA-ZF-AA56-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85d9812c-68d6-4bdf-8674-bccf1eb0c8a8	26bda3c7-7369-4096-8905-08248b5bb9f1	g.chr14:70926021C>T	ENST00000603540.1	+	2	2063	c.1805C>T	c.(1804-1806)tCt>tTt	p.S602F	RP11-486O13.4_ENST00000556646.1_lincRNA|ADAM21_ENST00000267499.3_Missense_Mutation_p.S602F	NM_003813.3	NP_003804.2	Q9UKJ8	ADA21_HUMAN	ADAM metallopeptidase domain 21	602	Cys-rich.				proteolysis|single fertilization	integral to membrane	metalloendopeptidase activity|zinc ion binding			central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(10)|lung(10)|pancreas(1)|prostate(1)|skin(2)|stomach(1)	31				all cancers(60;0.00326)|BRCA - Breast invasive adenocarcinoma(234;0.00646)|OV - Ovarian serous cystadenocarcinoma(108;0.0401)		ATGAACATATCTGACATTGGT	0.428000													10	59					0	0	1	0	0
HSPH1	10808	broad.mit.edu	37	13	31719799	31719799	+	Silent	SNP	T	T	C			TCGA-ZF-AA56-01A-31D-A391-08	TCGA-ZF-AA56-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85d9812c-68d6-4bdf-8674-bccf1eb0c8a8	26bda3c7-7369-4096-8905-08248b5bb9f1	g.chr13:31719799T>C	ENST00000320027.5	-	11	1829	c.1485A>G	c.(1483-1485)gcA>gcG	p.A495A	HSPH1_ENST00000429785.2_Silent_p.A314A|HSPH1_ENST00000380406.5_Silent_p.A454A|HSPH1_ENST00000380405.4_Silent_p.A495A|HSPH1_ENST00000445273.2_Silent_p.A497A	NM_006644.2	NP_006635.2	Q92598	HS105_HUMAN	heat shock 105kDa/110kDa protein 1	495					positive regulation of MHC class I biosynthetic process|positive regulation of NK T cell activation|response to unfolded protein	cytoplasm|extracellular region	ATP binding			breast(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(4)|lung(7)|ovary(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	27		Lung SC(185;0.0257)		all cancers(112;0.00385)|Epithelial(112;0.0328)|OV - Ovarian serous cystadenocarcinoma(117;0.0375)|GBM - Glioblastoma multiforme(144;0.125)		CCACCATAGATGCCGTAGAGA	0.433000													4	97					0	0	1	0	0
CBFA2T2	9139	broad.mit.edu	37	20	32217585	32217585	+	Missense_Mutation	SNP	C	C	T	rs140481995		TCGA-ZF-AA56-01A-31D-A391-08	TCGA-ZF-AA56-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85d9812c-68d6-4bdf-8674-bccf1eb0c8a8	26bda3c7-7369-4096-8905-08248b5bb9f1	g.chr20:32217585C>T	ENST00000492345.1	+	10	1718	c.1033C>T	c.(1033-1035)Cgc>Tgc	p.R345C	CBFA2T2_ENST00000359606.3_Missense_Mutation_p.R384C|CBFA2T2_ENST00000397800.1_Missense_Mutation_p.R345C|CBFA2T2_ENST00000375279.2_Missense_Mutation_p.R374C|CBFA2T2_ENST00000346541.3_Missense_Mutation_p.R374C|CBFA2T2_ENST00000491618.1_3'UTR|CBFA2T2_ENST00000342704.6_Missense_Mutation_p.R365C			O43439	MTG8R_HUMAN	core-binding factor, runt domain, alpha subunit 2; translocated to, 2	374						nucleus	protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|central_nervous_system(3)|endometrium(1)|kidney(2)|large_intestine(4)|lung(4)|pancreas(1)|prostate(2)|skin(2)	20						AGTTCTGCGGCGCTGTCAGGA	0.502000													6	73					0	0	1	0	0
C3	718	broad.mit.edu	37	19	6714367	6714367	+	Missense_Mutation	SNP	C	C	T	rs147549358		TCGA-ZF-AA56-01A-31D-A391-08	TCGA-ZF-AA56-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85d9812c-68d6-4bdf-8674-bccf1eb0c8a8	26bda3c7-7369-4096-8905-08248b5bb9f1	g.chr19:6714367C>T	ENST00000245907.6	-	5	687	c.595G>A	c.(595-597)Gtc>Atc	p.V199I		NM_000064.2	NP_000055.2	P01024	CO3_HUMAN	complement component 3	199					complement activation, alternative pathway|complement activation, classical pathway|G-protein coupled receptor protein signaling pathway|inflammatory response|positive regulation vascular endothelial growth factor production	extracellular space	endopeptidase inhibitor activity|receptor binding			breast(5)|endometrium(7)|kidney(6)|large_intestine(18)|liver(1)|lung(18)|ovary(1)|pancreas(1)|prostate(5)|skin(7)|upper_aerodigestive_tract(3)	72				GBM - Glioblastoma multiforme(1328;1.36e-05)|Lung(535;0.00661)		ACATACTTGACGAGTTCCGGA	0.617000													8	21					0	0	1	0	0
NEB	4703	broad.mit.edu	37	2	152348641	152348641	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA56-01A-31D-A391-08	TCGA-ZF-AA56-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85d9812c-68d6-4bdf-8674-bccf1eb0c8a8	26bda3c7-7369-4096-8905-08248b5bb9f1	g.chr2:152348641C>T	ENST00000397345.3	-	178	25230	c.25028G>A	c.(25027-25029)cGg>cAg	p.R8343Q	RIF1_ENST00000457745.1_Intron|NEB_ENST00000397336.2_Missense_Mutation_p.R318Q|NEB_ENST00000172853.10_Missense_Mutation_p.R6487Q|NEB_ENST00000509223.2_Missense_Mutation_p.R256Q|NEB_ENST00000604864.1_Missense_Mutation_p.R8343Q|NEB_ENST00000427231.2_Missense_Mutation_p.R8343Q|NEB_ENST00000409198.1_Missense_Mutation_p.R6487Q|NEB_ENST00000603639.1_Missense_Mutation_p.R8343Q|NEB_ENST00000498015.2_5'UTR	NM_001164508.1	NP_001157980	P20929	NEBU_HUMAN	nebulin	6487					muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			NS(5)|autonomic_ganglia(3)|breast(9)|central_nervous_system(5)|cervix(3)|endometrium(35)|kidney(16)|large_intestine(77)|liver(1)|lung(99)|ovary(9)|pancreas(3)|prostate(13)|skin(7)|stomach(8)|upper_aerodigestive_tract(6)|urinary_tract(2)	301				BRCA - Breast invasive adenocarcinoma(221;0.219)		TTGGTCATTCCGTTTTTGTTC	0.433000													14	139					0	0	1	0	0
YLPM1	56252	broad.mit.edu	37	14	75283677	75283677	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA56-01A-31D-A391-08	TCGA-ZF-AA56-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85d9812c-68d6-4bdf-8674-bccf1eb0c8a8	26bda3c7-7369-4096-8905-08248b5bb9f1	g.chr14:75283677G>A	ENST00000325680.7	+	14	5853	c.5729G>A	c.(5728-5730)cGc>cAc	p.R1910H	YLPM1_ENST00000552421.1_Missense_Mutation_p.R1204H|YLPM1_ENST00000238571.3_Missense_Mutation_p.R1675H	NM_019589.2	NP_062535.2	P49750	YLPM1_HUMAN	YLP motif containing 1	1715					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear speck				breast(4)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(12)|lung(24)|ovary(3)|pancreas(1)|prostate(1)|skin(1)|urinary_tract(1)	62			KIRC - Kidney renal clear cell carcinoma(43;0.238)	BRCA - Breast invasive adenocarcinoma(234;0.00162)		GAGACTTACCGCACCAGCATG	0.408000													4	18					0	0	1	0	0
TRBV7-6	28592	broad.mit.edu	37	7	142139483	142139483	+	RNA	SNP	G	G	T			TCGA-ZF-AA56-01A-31D-A391-08	TCGA-ZF-AA56-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85d9812c-68d6-4bdf-8674-bccf1eb0c8a8	26bda3c7-7369-4096-8905-08248b5bb9f1	g.chr7:142139483G>T	ENST00000390374.3	-	0	186																											AGGGATACATGACCCGAAATT	0.512000													7	53					2.0095e-06	2.12947e-06	1	1	0
UBQLN1	29979	broad.mit.edu	37	9	86284243	86284243	+	Splice_Site	SNP	C	C	G			TCGA-ZF-AA56-01A-31D-A391-08	TCGA-ZF-AA56-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85d9812c-68d6-4bdf-8674-bccf1eb0c8a8	26bda3c7-7369-4096-8905-08248b5bb9f1	g.chr9:86284243C>G	ENST00000376395.4	-	7	1629		c.e7-1		UBQLN1_ENST00000257468.7_Splice_Site	NM_013438.4|NM_053067.2	NP_038466.2|NP_444295.1	Q9UMX0	UBQL1_HUMAN	ubiquilin 1						apoptosis|regulation of protein ubiquitination|response to hypoxia	endoplasmic reticulum|nucleus|perinuclear region of cytoplasm|proteasome complex	kinase binding			breast(4)|endometrium(2)|kidney(4)|large_intestine(6)|lung(10)|prostate(1)	27						AACATACTAGCTGAAAGTTTG	0.328000													14	30					0	0	1	0	0
RIT2	6014	broad.mit.edu	37	18	40323631	40323631	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA56-01A-31D-A391-08	TCGA-ZF-AA56-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85d9812c-68d6-4bdf-8674-bccf1eb0c8a8	26bda3c7-7369-4096-8905-08248b5bb9f1	g.chr18:40323631C>G	ENST00000326695.5	-	5	652	c.481G>C	c.(481-483)Gag>Cag	p.E161Q	RIT2_ENST00000589109.1_3'UTR|RIT2_ENST00000590910.1_3'UTR	NM_002930.2	NP_002921.1	Q99578	RIT2_HUMAN	Ras-like without CAAX 2	161					nerve growth factor receptor signaling pathway|small GTPase mediated signal transduction|synaptic transmission	intracellular|plasma membrane	calmodulin binding|GTP binding|GTPase activity			endometrium(1)|large_intestine(2)|lung(11)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	19						GCAGAGGTCTCAAAAAAACCA	0.378000													4	36					0	0	1	0	0
ITLN1	55600	broad.mit.edu	37	1	160851088	160851088	+	Silent	SNP	G	G	A	rs142202671		TCGA-ZF-AA56-01A-31D-A391-08	TCGA-ZF-AA56-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85d9812c-68d6-4bdf-8674-bccf1eb0c8a8	26bda3c7-7369-4096-8905-08248b5bb9f1	g.chr1:160851088G>A	ENST00000326245.3	-	5	535	c.420C>T	c.(418-420)taC>taT	p.Y140Y	ITLN1_ENST00000487531.1_5'UTR	NM_017625.2	NP_060095.2	Q8WWA0	ITLN1_HUMAN	intelectin 1 (galactofuranose binding)	140	Fibrinogen C-terminal.				positive regulation of glucose import|positive regulation of protein phosphorylation|response to nematode|signal transduction	anchored to membrane|brush border membrane|extracellular region|membrane raft	receptor binding|sugar binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(1)|lung(6)|ovary(2)|pancreas(1)|skin(3)|upper_aerodigestive_tract(1)	21	all_cancers(52;2.99e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00737)			CCTGGATGTCGTAGTAGCCAG	0.592000													5	57					0	0	1	0	0
CDH26	60437	broad.mit.edu	37	20	58560179	58560179	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA56-01A-31D-A391-08	TCGA-ZF-AA56-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85d9812c-68d6-4bdf-8674-bccf1eb0c8a8	26bda3c7-7369-4096-8905-08248b5bb9f1	g.chr20:58560179G>A	ENST00000348616.4	+	7	1132	c.832G>A	c.(832-834)Gag>Aag	p.E278K	CDH26_ENST00000244047.5_Missense_Mutation_p.E278K	NM_177980.2	NP_817089.1	Q8IXH8	CAD26_HUMAN	cadherin 26	278	Cadherin 3.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(11)|lung(14)|ovary(4)|pancreas(2)|prostate(2)|skin(2)|urinary_tract(1)	44	all_lung(29;0.00963)		BRCA - Breast invasive adenocarcinoma(7;5.58e-09)			ATTTACCCAGGAGAACGTGAG	0.552000													8	28					0	0	1	0	0
PLCE1	51196	broad.mit.edu	37	10	95791022	95791022	+	Silent	SNP	C	C	G			TCGA-ZF-AA56-01A-31D-A391-08	TCGA-ZF-AA56-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85d9812c-68d6-4bdf-8674-bccf1eb0c8a8	26bda3c7-7369-4096-8905-08248b5bb9f1	g.chr10:95791022C>G	ENST00000371380.3	+	1	454	c.219C>G	c.(217-219)ctC>ctG	p.L73L	PLCE1_ENST00000260766.3_Silent_p.L73L			Q9P212	PLCE1_HUMAN	phospholipase C, epsilon 1						activation of MAPK activity|activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|calcium-mediated signaling|cell proliferation|cytoskeleton organization|diacylglycerol biosynthetic process|elevation of cytosolic calcium ion concentration|epidermal growth factor receptor signaling pathway|glomerulus development|heart development|lipid catabolic process|Ras protein signal transduction|regulation of cell growth|regulation of G-protein coupled receptor protein signaling pathway|regulation of Ras protein signal transduction|regulation of smooth muscle contraction	cytosol|Golgi membrane|membrane fraction|plasma membrane	calcium ion binding|guanyl-nucleotide exchange factor activity|phosphatidylinositol phospholipase C activity|Ras GTPase binding|receptor signaling protein activity			liver(1)|ovary(2)|skin(4)|upper_aerodigestive_tract(1)	8		Colorectal(252;0.0458)				CAAAGATTCTCTCAATAGCGA	0.398000													9	66					0	0	1	0	0
PSMC6	5706	broad.mit.edu	37	14	53185005	53185005	+	Missense_Mutation	SNP	A	A	T			TCGA-ZF-AA56-01A-31D-A391-08	TCGA-ZF-AA56-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85d9812c-68d6-4bdf-8674-bccf1eb0c8a8	26bda3c7-7369-4096-8905-08248b5bb9f1	g.chr14:53185005A>T	ENST00000445930.2	+	9	698	c.692A>T	c.(691-693)gAa>gTa	p.E231V	PSMC6_ENST00000606149.1_Missense_Mutation_p.E217V			P62333	PRS10_HUMAN	proteasome (prosome, macropain) 26S subunit, ATPase, 6	217					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	cytoplasm|nucleus|proteasome complex	ATP binding|ATPase activity|protein binding, bridging			breast(2)|endometrium(3)|kidney(2)|large_intestine(4)|lung(6)|prostate(1)|stomach(1)	19	Breast(41;0.176)					TTGATCAGAGAAATGTTTAAT	0.313000													17	91					0	0	1	0	0
AQP7	364	broad.mit.edu	37	9	33385614	33385614	+	Missense_Mutation	SNP	A	A	T	rs140995428	by1000genomes	TCGA-ZF-AA56-01A-31D-A391-08	TCGA-ZF-AA56-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85d9812c-68d6-4bdf-8674-bccf1eb0c8a8	26bda3c7-7369-4096-8905-08248b5bb9f1	g.chr9:33385614A>T	ENST00000541274.1	-	5	830	c.381T>A	c.(379-381)agT>agA	p.S127R	AQP7_ENST00000537089.1_3'UTR|AQP7_ENST00000539936.1_3'UTR|AQP7_ENST00000377425.4_Intron			O14520	AQP7_HUMAN	aquaporin 7	0					excretion|generation of precursor metabolites and energy	cell-cell junction|cytoplasm|integral to plasma membrane	glycerol channel activity|water channel activity			NS(1)|large_intestine(1)|lung(7)|ovary(1)|prostate(4)|skin(2)|stomach(1)	17			LUSC - Lung squamous cell carcinoma(29;0.00788)	GBM - Glioblastoma multiforme(74;0.191)		CCACAGAAAAACTCAAAGGAA	0.632000													4	46					0	0	1	0	0
YTHDC1	91746	broad.mit.edu	37	4	69184271	69184271	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-AA56-01A-31D-A391-08	TCGA-ZF-AA56-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85d9812c-68d6-4bdf-8674-bccf1eb0c8a8	26bda3c7-7369-4096-8905-08248b5bb9f1	g.chr4:69184271T>C	ENST00000344157.4	-	15	2125	c.1790A>G	c.(1789-1791)cAt>cGt	p.H597R	YTHDC1_ENST00000355665.3_Missense_Mutation_p.H579R|YTHDC1_ENST00000579690.1_Missense_Mutation_p.H605R	NM_001031732.2	NP_001026902.1	Q96MU7	YTDC1_HUMAN	YTH domain containing 1	597										NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|lung(7)|ovary(1)|prostate(1)|upper_aerodigestive_tract(2)	30						TCCCATGTTATGAAATTCCCT	0.303000													9	35					0	0	1	0	0
SOS1	6654	broad.mit.edu	37	2	39234291	39234291	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-AA56-01A-31D-A391-08	TCGA-ZF-AA56-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85d9812c-68d6-4bdf-8674-bccf1eb0c8a8	26bda3c7-7369-4096-8905-08248b5bb9f1	g.chr2:39234291C>A	ENST00000426016.1	-	17	2640	c.2554G>T	c.(2554-2556)Gtg>Ttg	p.V852L	SOS1_ENST00000395038.2_Missense_Mutation_p.V852L|SOS1_ENST00000402219.2_Missense_Mutation_p.V852L			Q07889	SOS1_HUMAN	son of sevenless homolog 1 (Drosophila)	852	Ras-GEF.				apoptosis|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|induction of apoptosis by extracellular signals|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	cytosol	DNA binding|protein binding|Rho GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			autonomic_ganglia(1)|breast(6)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(9)|liver(1)|lung(29)|ovary(4)|prostate(1)|skin(4)|stomach(1)|urinary_tract(2)	75		all_hematologic(82;0.21)				ATTCGACTCACCACAGCTACT	0.328000									Noonan syndrome				7	143					0.27861	0.27861	1	1	0
TULP1	7287	broad.mit.edu	37	6	35478658	35478658	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA56-01A-31D-A391-08	TCGA-ZF-AA56-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85d9812c-68d6-4bdf-8674-bccf1eb0c8a8	26bda3c7-7369-4096-8905-08248b5bb9f1	g.chr6:35478658G>A	ENST00000229771.6	-	5	558	c.479C>T	c.(478-480)gCc>gTc	p.A160V	TULP1_ENST00000322263.4_Missense_Mutation_p.A107V	NM_003322.3	NP_003313.3	O00294	TULP1_HUMAN	tubby like protein 1	160					dendrite development|eye photoreceptor cell development|phagocytosis|photoreceptor cell maintenance|positive regulation of phagocytosis	cell junction|cytoplasm|extracellular region|photoreceptor inner segment|photoreceptor outer segment|synapse	actin filament binding|phosphatidylinositol-4,5-bisphosphate binding			central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(5)|ovary(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	19						CTGGGCCTTGGCCCTCCTCTC	0.597000													10	66					0	0	1	0	0
ELF3	1999	broad.mit.edu	37	1	201981535	201981536	+	Frame_Shift_Ins	INS	-	-	C			TCGA-ZF-AA56-01A-31D-A391-08	TCGA-ZF-AA56-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85d9812c-68d6-4bdf-8674-bccf1eb0c8a8	26bda3c7-7369-4096-8905-08248b5bb9f1	g.chr1:201981535_201981536insC	ENST00000359651.3	+	3	3641_3642	c.449_450insC	c.(448-453)ttccagfs	p.Q151fs	ELF3_ENST00000367283.3_Frame_Shift_Ins_p.Q151fs|ELF3_ENST00000367284.5_Frame_Shift_Ins_p.Q151fs|ELF3_ENST00000495848.1_3'UTR|RP11-510N19.5_ENST00000504773.1_RNA			P78545	ELF3_HUMAN	E74-like factor 3 (ets domain transcription factor, epithelial-specific )	151					epidermis development|epithelial cell differentiation|inflammatory response|mammary gland involution|negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	Golgi apparatus|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity	p.M148fs*7(1)		breast(2)|endometrium(2)|large_intestine(6)|lung(5)|ovary(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	20						GGCATGGCCTTCCAGGAGGCCC	0.564													24	48	---	---	---	---					
RP11-400N13.1	0	broad.mit.edu	37	1	222435118	222435118	+	RNA	DEL	C	C	-			TCGA-ZF-AA56-01A-31D-A391-08	TCGA-ZF-AA56-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85d9812c-68d6-4bdf-8674-bccf1eb0c8a8	26bda3c7-7369-4096-8905-08248b5bb9f1	g.chr1:222435118delC	ENST00000416510.1	-	0	167																											GCAATAATTTCTTTTTTTTTT	0.303													2	4	---	---	---	---					
NUTM2F	54754	broad.mit.edu	37	9	97080945	97080947	+	In_Frame_Del	DEL	AGA	AGA	-			TCGA-ZF-AA56-01A-31D-A391-08	TCGA-ZF-AA56-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85d9812c-68d6-4bdf-8674-bccf1eb0c8a8	26bda3c7-7369-4096-8905-08248b5bb9f1	g.chr9:97080945_97080947delAGA	ENST00000253262.4	-	7	2091_2093	c.2071_2073delTCT	c.(2071-2073)tctdel	p.S691del	NUTM2F_ENST00000341207.4_In_Frame_Del_p.S676del|NUTM2F_ENST00000335456.7_Intron	NM_017561.1	NP_060031.1			NUT family member 2F									p.S557delS(1)									TGCTGGCAGGAGAAGGTGATGGG	0.611													5	3	---	---	---	---					
CEP170B	283638	broad.mit.edu	37	14	105352885	105352890	+	In_Frame_Del	DEL	GCAGGA	GCAGGA	-	rs60001925		TCGA-ZF-AA56-01A-31D-A391-08	TCGA-ZF-AA56-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85d9812c-68d6-4bdf-8674-bccf1eb0c8a8	26bda3c7-7369-4096-8905-08248b5bb9f1	g.chr14:105352885_105352890delGCAGGA	ENST00000453495.1	+	12	2540_2545	c.2312_2317delGCAGGA	c.(2311-2319)cgcaggagc>cgc	p.RS772del	CEP170B_ENST00000556508.1_In_Frame_Del_p.RS701del|CEP170B_ENST00000414716.3_In_Frame_Del_p.RS771del|CEP170B_ENST00000418279.1_In_Frame_Del_p.RS701del					centrosomal protein 170B																		GACAGCAGACGCAGGAGCCCCCAGGA	0.694													5	6	---	---	---	---					
C17orf70	80233	broad.mit.edu	37	17	79514428	79514429	+	Frame_Shift_Ins	INS	-	-	CAGGCCGAGTC	rs147474907	by1000genomes	TCGA-ZF-AA56-01A-31D-A391-08	TCGA-ZF-AA56-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85d9812c-68d6-4bdf-8674-bccf1eb0c8a8	26bda3c7-7369-4096-8905-08248b5bb9f1	g.chr17:79514428_79514429insCAGGCCGAGTC	ENST00000537152.1	-	5	1751_1752	c.1226_1227insGACTCGGCCTG	c.(1225-1227)tgcfs	p.C409fs	C17orf70_ENST00000327787.8_Frame_Shift_Ins_p.C560fs|C17orf70_ENST00000425898.2_Frame_Shift_Ins_p.C209fs	NM_025161.5	NP_079437.5	Q0VG06	FP100_HUMAN	chromosome 17 open reading frame 70	560					DNA repair	cytoplasm|intermediate filament cytoskeleton|nucleoplasm	DNA binding			breast(1)|central_nervous_system(1)|endometrium(1)|lung(11)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	19	all_neural(118;0.0878)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0282)|OV - Ovarian serous cystadenocarcinoma(97;0.0371)			TGATGGCGGAGCAGGCCGAGTC	0.678													19	60	---	---	---	---					
KDM6A	7403	broad.mit.edu	37	X	44950105	44950106	+	Frame_Shift_Ins	INS	-	-	T			TCGA-ZF-AA56-01A-31D-A391-08	TCGA-ZF-AA56-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85d9812c-68d6-4bdf-8674-bccf1eb0c8a8	26bda3c7-7369-4096-8905-08248b5bb9f1	g.chrX:44950105_44950106insT	ENST00000377967.4	+	26	3915_3916	c.3874_3875insT	c.(3874-3876)attfs	p.I1292fs	KDM6A_ENST00000536777.1_Frame_Shift_Ins_p.I1247fs|KDM6A_ENST00000543216.1_Frame_Shift_Ins_p.I1213fs|KDM6A_ENST00000382899.4_Frame_Shift_Ins_p.I1299fs	NM_021140.2	NP_066963.2	O15550	KDM6A_HUMAN	lysine (K)-specific demethylase 6A	1292					histone H3-K4 methylation		metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	p.0?(6)		NS(1)|breast(7)|central_nervous_system(27)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(24)|kidney(24)|large_intestine(9)|liver(1)|lung(21)|oesophagus(11)|pancreas(2)|prostate(5)|skin(1)|soft_tissue(1)|urinary_tract(29)	170						TTTTGAAATGATTAAGTAAGTC	0.356			"""D, N, F, S"""		"""renal, oesophageal SCC, MM"""								15	96	---	---	---	---