Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
FLRT2	23768	broad.mit.edu	37	14	86089505	86089505	+	Silent	SNP	C	C	T	rs35699071		TCGA-ZF-AA5P-01A-11D-A391-08	TCGA-ZF-AA5P-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0fec8a1-76ee-40a1-80c5-4cf8ab5540c6	9375b535-87d5-4b4e-81ab-8986e4e1dce3	g.chr14:86089505C>T	ENST00000330753.4	+	2	2414	c.1647C>T	c.(1645-1647)ggC>ggT	p.G549G	FLRT2_ENST00000554746.1_Silent_p.G549G	NM_013231.4	NP_037363.1	O43155	FLRT2_HUMAN	fibronectin leucine rich transmembrane protein 2	549					cell adhesion	integral to plasma membrane|proteinaceous extracellular matrix	protein binding, bridging|receptor signaling protein activity			NS(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|large_intestine(21)|lung(27)|ovary(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	73				BRCA - Breast invasive adenocarcinoma(234;0.0319)		TGATCGGGGGCGCGGTGATAT	0.587000													10	109					0	0	1	0	0
FRG1B	284802	broad.mit.edu	37	20	29625961	29625961	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-AA5P-01A-11D-A391-08	TCGA-ZF-AA5P-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0fec8a1-76ee-40a1-80c5-4cf8ab5540c6	9375b535-87d5-4b4e-81ab-8986e4e1dce3	g.chr20:29625961C>A	ENST00000278882.3	+	5	585	c.205C>A	c.(205-207)Caa>Aaa	p.Q69K	FRG1B_ENST00000439954.2_Missense_Mutation_p.Q74K|FRG1B_ENST00000358464.4_Missense_Mutation_p.Q69K														p.Q69K(2)		endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						ACCAAGAGAACAATGGGAACC	0.333000													5	115					0.248553	0.251142	1	1	0
HIST1H1B	3009	broad.mit.edu	37	6	27835085	27835085	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA5P-01A-11D-A391-08	TCGA-ZF-AA5P-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0fec8a1-76ee-40a1-80c5-4cf8ab5540c6	9375b535-87d5-4b4e-81ab-8986e4e1dce3	g.chr6:27835085C>T	ENST00000331442.3	-	1	274	c.223G>A	c.(223-225)Gac>Aac	p.D75N		NM_005322.2	NP_005313.1	P16401	H15_HUMAN	histone cluster 1, H1b	75	H15.				nucleosome assembly	nucleosome|nucleus	DNA binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(5)|lung(12)|prostate(2)|upper_aerodigestive_tract(2)	24						TTCTCCACGTCGTAGCCACCG	0.577000													5	217					0	0	1	0	0
NBPF10	100132406	broad.mit.edu	37	1	145302714	145302714	+	Silent	SNP	A	A	G	rs9424867		TCGA-ZF-AA5P-01A-11D-A391-08	TCGA-ZF-AA5P-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0fec8a1-76ee-40a1-80c5-4cf8ab5540c6	9375b535-87d5-4b4e-81ab-8986e4e1dce3	g.chr1:145302714A>G	ENST00000342960.5	+	8	1187	c.1152A>G	c.(1150-1152)ttA>ttG	p.L384L	NBPF10_ENST00000369338.1_Silent_p.L113L|RP11-458D21.5_ENST00000468030.1_3'UTR|NBPF10_ENST00000369339.3_Silent_p.L113L	NM_001039703.4	NP_001034792.4	A6NDV3	A6NDV3_HUMAN	neuroblastoma breakpoint family, member 10	384								p.L113L(3)|p.L384L(3)		NS(3)|breast(1)|central_nervous_system(3)|endometrium(12)|kidney(23)|lung(15)|ovary(1)|prostate(7)|skin(6)|urinary_tract(2)	73	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		AGGAGAAGTTACGGGAAGGGA	0.527000													3	75					0	0	1	0	0
PIK3CA	5290	broad.mit.edu	37	3	178916876	178916876	+	Missense_Mutation	SNP	G	G	A	rs121913287		TCGA-ZF-AA5P-01A-11D-A391-08	TCGA-ZF-AA5P-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0fec8a1-76ee-40a1-80c5-4cf8ab5540c6	9375b535-87d5-4b4e-81ab-8986e4e1dce3	g.chr3:178916876G>A	ENST00000263967.3	+	2	420	c.263G>A	c.(262-264)cGa>cAa	p.R88Q		NM_006218.2	NP_006209.2	P42336	PK3CA_HUMAN	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha	88	PI3K-ABD.		R -> Q (in cancer; may disrupt the interaction between the PI3K-ABD domain and the N-terminal lobe of PI3K/PI4K kinase domain possibly affecting the conformation of the kinase domain).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.R88Q(53)		NS(16)|autonomic_ganglia(4)|biliary_tract(22)|bone(1)|breast(2150)|central_nervous_system(110)|cervix(33)|endometrium(473)|eye(1)|haematopoietic_and_lymphoid_tissue(35)|kidney(14)|large_intestine(1202)|liver(42)|lung(202)|meninges(1)|oesophagus(28)|ovary(235)|pancreas(17)|penis(8)|pituitary(12)|prostate(10)|skin(155)|small_intestine(1)|soft_tissue(18)|stomach(121)|thyroid(80)|upper_aerodigestive_tract(70)|urinary_tract(208)	5269	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			GAAACAAGACGACTTTGTGAC	0.363000	R88Q(JHUEM1_ENDOMETRIUM)|R88Q(SKUT1_SOFT_TISSUE)|R88Q(SNGM_ENDOMETRIUM)	57	Mis		"""colorectal, gastric, gliobastoma, breast"""					HNSCC(19;0.045)|TSP Lung(28;0.18)			8	84					0	0	1	0	0
OR2T33	391195	broad.mit.edu	37	1	248436184	248436184	+	Missense_Mutation	SNP	G	G	T	rs142308940	byFrequency	TCGA-ZF-AA5P-01A-11D-A391-08	TCGA-ZF-AA5P-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0fec8a1-76ee-40a1-80c5-4cf8ab5540c6	9375b535-87d5-4b4e-81ab-8986e4e1dce3	g.chr1:248436184G>T	ENST00000318021.2	-	1	954	c.933C>A	c.(931-933)caC>caA	p.H311Q		NM_001004695.1	NP_001004695.1	Q8NG76	O2T33_HUMAN	olfactory receptor, family 2, subfamily T, member 33	311					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(2)|breast(1)|endometrium(6)|kidney(1)|large_intestine(10)|lung(41)|ovary(1)|prostate(1)|skin(4)	67	all_cancers(71;0.000124)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			CATTTTGCTGGTGTTTTATGT	0.418000													13	183					2.31682e-05	2.67538e-05	1	1	0
HTR1A	3350	broad.mit.edu	37	5	63256914	63256914	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-AA5P-01A-11D-A391-08	TCGA-ZF-AA5P-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0fec8a1-76ee-40a1-80c5-4cf8ab5540c6	9375b535-87d5-4b4e-81ab-8986e4e1dce3	g.chr5:63256914C>A	ENST00000323865.3	-	1	866	c.633G>T	c.(631-633)atG>atT	p.M211I	RP11-158J3.2_ENST00000502882.1_RNA	NM_000524.3	NP_000515.2	P08908	5HT1A_HUMAN	5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled	211					behavior|positive regulation of cell proliferation	integral to plasma membrane	serotonin receptor activity			cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(11)|lung(29)|ovary(2)|pancreas(2)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)	56		Lung NSC(810;3.55e-06)|Prostate(74;0.0352)|Ovarian(174;0.0545)|Breast(144;0.0575)|Colorectal(97;0.234)		Lung(70;0.105)	Alprenolol(DB00866)|Aripiprazole(DB01238)|Buspirone(DB00490)|Clozapine(DB00363)|Eletriptan(DB00216)|Ergoloid mesylate(DB01049)|Fluvoxamine(DB00176)|Lisuride(DB00589)|Methysergide(DB00247)|Mirtazapine(DB00370)|Pindolol(DB00960)|Propranolol(DB00571)|Quetiapine(DB01224)|Sertraline(DB01104)|Tegaserod(DB01079)|Trazodone(DB00656)|Venlafaxine(DB00285)|Ziprasidone(DB00246)	AGAGAACCAGCATGAGCAGCA	0.572000													6	139					3.59834e-05	4.10634e-05	1	1	0
COL5A2	1290	broad.mit.edu	37	2	189904098	189904098	+	Silent	SNP	G	G	T			TCGA-ZF-AA5P-01A-11D-A391-08	TCGA-ZF-AA5P-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0fec8a1-76ee-40a1-80c5-4cf8ab5540c6	9375b535-87d5-4b4e-81ab-8986e4e1dce3	g.chr2:189904098G>T	ENST00000374866.3	-	51	4099	c.3825C>A	c.(3823-3825)ctC>ctA	p.L1275L		NM_000393.3	NP_000384.2	P05997	CO5A2_HUMAN	collagen, type V, alpha 2	1275	Fibrillar collagen NC1.				axon guidance|collagen fibril organization|eye morphogenesis|skin development	collagen type V	extracellular matrix structural constituent			NS(3)|breast(2)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(16)|lung(53)|ovary(3)|prostate(2)|skin(6)|urinary_tract(3)	95			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.127)			TCTGACTACTGAGTGACTTCA	0.517000													10	55					1.58986e-06	1.88069e-06	1	1	0
FCRL1	115350	broad.mit.edu	37	1	157772202	157772202	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA5P-01A-11D-A391-08	TCGA-ZF-AA5P-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0fec8a1-76ee-40a1-80c5-4cf8ab5540c6	9375b535-87d5-4b4e-81ab-8986e4e1dce3	g.chr1:157772202G>A	ENST00000358292.3	-	4	623	c.572C>T	c.(571-573)cCc>cTc	p.P191L	FCRL1_ENST00000368176.3_Missense_Mutation_p.P191L|FCRL1_ENST00000489998.1_5'UTR|FCRL1_ENST00000491942.1_Missense_Mutation_p.P191L	NM_001159397.1	NP_001152869.1	Q96LA6	FCRL1_HUMAN	Fc receptor-like 1	191	Ig-like C2-type 2.					integral to membrane|plasma membrane	receptor activity			breast(2)|cervix(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(1)|lung(24)|ovary(4)|prostate(1)|skin(6)	42	all_hematologic(112;0.0378)		LUSC - Lung squamous cell carcinoma(543;0.24)			ACTGGGGCTGGGACCATAGCC	0.517000													15	70					0	0	1	0	0
MLLT3	4300	broad.mit.edu	37	9	20414280	20414280	+	Silent	SNP	G	G	A			TCGA-ZF-AA5P-01A-11D-A391-08	TCGA-ZF-AA5P-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0fec8a1-76ee-40a1-80c5-4cf8ab5540c6	9375b535-87d5-4b4e-81ab-8986e4e1dce3	g.chr9:20414280G>A	ENST00000380338.4	-	5	850	c.564C>T	c.(562-564)agC>agT	p.S188S	MLLT3_ENST00000355930.6_5'UTR|MLLT3_ENST00000429426.2_Silent_p.S185S|MLLT3_ENST00000475957.1_5'UTR	NM_004529.2	NP_004520.2	P42568	AF9_HUMAN	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3	188	Poly-Ser.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding	p.S188S(1)		central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(6)|lung(24)|ovary(1)|prostate(4)|skin(1)|urinary_tract(7)	66				GBM - Glioblastoma multiforme(3;4.35e-105)|Lung(42;3.48e-06)|LUSC - Lung squamous cell carcinoma(42;7.92e-05)		TGGTActactgctgctgctgc	0.502000			T	MLL	ALL								4	116					0	0	1	0	0
GLIS3	169792	broad.mit.edu	37	9	4118581	4118581	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA5P-01A-11D-A391-08	TCGA-ZF-AA5P-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0fec8a1-76ee-40a1-80c5-4cf8ab5540c6	9375b535-87d5-4b4e-81ab-8986e4e1dce3	g.chr9:4118581C>G	ENST00000324333.10	-	3	625	c.432G>C	c.(430-432)aaG>aaC	p.K144N	GLIS3_ENST00000381971.3_Missense_Mutation_p.K299N	NM_152629.3	NP_689842.3	Q8NEA6	GLIS3_HUMAN	GLIS family zinc finger 3	144	Ser-rich.				negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter		DNA binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|large_intestine(12)|lung(4)|ovary(2)|prostate(1)|skin(1)	26		Acute lymphoblastic leukemia(2;0.00464)|Breast(48;0.148)		Lung(2;0.00163)|GBM - Glioblastoma multiforme(50;0.00301)|LUSC - Lung squamous cell carcinoma(2;0.0148)		GCGCTCTCTTCTTGGAGCGGG	0.562000													6	81					0	0	1	0	0
NOL9	79707	broad.mit.edu	37	1	6610519	6610519	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA5P-01A-11D-A391-08	TCGA-ZF-AA5P-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0fec8a1-76ee-40a1-80c5-4cf8ab5540c6	9375b535-87d5-4b4e-81ab-8986e4e1dce3	g.chr1:6610519C>G	ENST00000377705.5	-	2	585	c.553G>C	c.(553-555)Gag>Cag	p.E185Q		NM_024654.4	NP_078930	Q5SY16	NOL9_HUMAN	nucleolar protein 9	185					maturation of 5.8S rRNA	nucleolus	ATP binding|polynucleotide 5'-hydroxyl-kinase activity|RNA binding			central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(2)|lung(9)|skin(2)|urinary_tract(1)	19	Ovarian(185;0.0212)|all_lung(157;0.154)	all_cancers(23;2.46e-35)|all_epithelial(116;1.41e-22)|all_lung(118;7.59e-07)|Lung NSC(185;4.28e-06)|Colorectal(325;4.52e-05)|Breast(487;0.000353)|Renal(390;0.0007)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0443)		Colorectal(212;1.47e-07)|COAD - Colon adenocarcinoma(227;1.47e-05)|Kidney(185;5.27e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000971)|BRCA - Breast invasive adenocarcinoma(365;0.00113)|STAD - Stomach adenocarcinoma(132;0.0017)|READ - Rectum adenocarcinoma(331;0.0649)		TTGCTTTTCTCAGGCTGTGAG	0.448000													7	127					0	0	1	0	0
ZNF259	8882	broad.mit.edu	37	11	116652910	116652910	+	Silent	SNP	C	C	T			TCGA-ZF-AA5P-01A-11D-A391-08	TCGA-ZF-AA5P-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0fec8a1-76ee-40a1-80c5-4cf8ab5540c6	9375b535-87d5-4b4e-81ab-8986e4e1dce3	g.chr11:116652910C>T	ENST00000227322.3	-	12	1202	c.1143G>A	c.(1141-1143)acG>acA	p.T381T		NM_003904.3	NP_003895.1	O75312	ZPR1_HUMAN	zinc finger protein 259	381					cell proliferation|signal transduction	cytoplasm|nucleolus				breast(1)|endometrium(1)|large_intestine(2)|lung(4)|upper_aerodigestive_tract(1)	9	all_hematologic(175;0.0487)	all_cancers(61;1.72e-06)|all_epithelial(67;0.000735)|Melanoma(852;0.022)|Acute lymphoblastic leukemia(157;0.0255)|Medulloblastoma(222;0.0523)|Breast(348;0.056)|all_hematologic(158;0.0588)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|Epithelial(105;5.61e-06)|all cancers(92;0.000139)|OV - Ovarian serous cystadenocarcinoma(223;0.153)		GTAGTCTCTCCGTCTGTCCAG	0.463000													3	44					0	0	1	0	0
XRN2	22803	broad.mit.edu	37	20	21307031	21307031	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA5P-01A-11D-A391-08	TCGA-ZF-AA5P-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0fec8a1-76ee-40a1-80c5-4cf8ab5540c6	9375b535-87d5-4b4e-81ab-8986e4e1dce3	g.chr20:21307031C>G	ENST00000377191.3	+	2	285	c.190C>G	c.(190-192)Cat>Gat	p.H64D	XRN2_ENST00000430571.2_Intron|XRN2_ENST00000539513.1_Missense_Mutation_p.H10D	NM_012255.3	NP_036387.2	Q9H0D6	XRN2_HUMAN	5'-3' exoribonuclease 2	64					cell growth|DNA catabolic process, exonucleolytic|mRNA processing|regulation of transcription, DNA-dependent|RNA catabolic process|spermatogenesis|transcription termination, DNA-dependent	nucleolus	5'-3' exoribonuclease activity|nucleic acid binding|protein binding|zinc ion binding			endometrium(5)|kidney(6)|large_intestine(10)|lung(12)|ovary(1)|skin(5)	39						TCCCTGTACTCATCCTGAAGA	0.348000													5	90					0	0	1	0	0
IGHV2-5	28457	broad.mit.edu	37	14	106494299	106494299	+	RNA	SNP	C	C	T			TCGA-ZF-AA5P-01A-11D-A391-08	TCGA-ZF-AA5P-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0fec8a1-76ee-40a1-80c5-4cf8ab5540c6	9375b535-87d5-4b4e-81ab-8986e4e1dce3	g.chr14:106494299C>T	ENST00000390597.2	-	0	212																											CACTCCAGGGCCTTTCCTGGG	0.552000													6	66					0	0	1	0	0
GSDMA	284110	broad.mit.edu	37	17	38130548	38130548	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-AA5P-01A-11D-A391-08	TCGA-ZF-AA5P-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0fec8a1-76ee-40a1-80c5-4cf8ab5540c6	9375b535-87d5-4b4e-81ab-8986e4e1dce3	g.chr17:38130548G>T	ENST00000301659.4	+	9	892	c.774G>T	c.(772-774)agG>agT	p.R258S		NM_178171.4	NP_835465.2	Q96QA5	GSDMA_HUMAN	gasdermin A	258					apoptosis|induction of apoptosis	perinuclear region of cytoplasm				NS(1)|endometrium(2)|large_intestine(3)|lung(1)	7						AAGGCTTCAGGACACTAAAAG	0.557000													3	16					0.004672	0.00503538	1	1	0
FMO2	2327	broad.mit.edu	37	1	171165877	171165877	+	Missense_Mutation	SNP	T	T	A			TCGA-ZF-AA5P-01A-11D-A391-08	TCGA-ZF-AA5P-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0fec8a1-76ee-40a1-80c5-4cf8ab5540c6	9375b535-87d5-4b4e-81ab-8986e4e1dce3	g.chr1:171165877T>A	ENST00000441535.1	+	4	528	c.411T>A	c.(409-411)agT>agA	p.S137R	FMO2_ENST00000209929.7_Missense_Mutation_p.S137R|FMO2_ENST00000529935.1_3'UTR	NM_001460.2	NP_001451.1	Q99518	FMO2_HUMAN	flavin containing monooxygenase 2 (non-functional)	137					drug metabolic process|NADPH oxidation|organic acid metabolic process|toxin metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|host cell microsome|integral to membrane|microsome	flavin adenine dinucleotide binding|flavin-containing monooxygenase activity|NADP binding			endometrium(2)|kidney(1)|large_intestine(5)|lung(7)|prostate(1)|skin(2)|stomach(3)|urinary_tract(1)	22	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					AGGAGCAGAGTGCTGTCTTTG	0.488000													4	87					0	0	1	0	0
C17orf85	55421	broad.mit.edu	37	17	3716490	3716490	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA5P-01A-11D-A391-08	TCGA-ZF-AA5P-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0fec8a1-76ee-40a1-80c5-4cf8ab5540c6	9375b535-87d5-4b4e-81ab-8986e4e1dce3	g.chr17:3716490C>T	ENST00000158149.3	-	14	1766	c.871G>A	c.(871-873)Gag>Aag	p.E291K	C17orf85_ENST00000389005.4_Missense_Mutation_p.E571K			Q53F19	CQ085_HUMAN	chromosome 17 open reading frame 85	571							nucleotide binding			endometrium(2)|large_intestine(2)|lung(4)|skin(1)|urinary_tract(1)	10				UCEC - Uterine corpus endometrioid carcinoma (3;0.0725)		TCGTCTTCCTCAGCGCCAGGC	0.498000													6	121					0	0	1	0	0
NKIRAS2	28511	broad.mit.edu	37	17	40175898	40175898	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA5P-01A-11D-A391-08	TCGA-ZF-AA5P-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0fec8a1-76ee-40a1-80c5-4cf8ab5540c6	9375b535-87d5-4b4e-81ab-8986e4e1dce3	g.chr17:40175898C>G	ENST00000307641.5	+	4	1184	c.563C>G	c.(562-564)tCc>tGc	p.S188C	NKIRAS2_ENST00000462043.2_3'UTR|NKIRAS2_ENST00000393884.2_Missense_Mutation_p.S186C|NKIRAS2_ENST00000393880.1_Missense_Mutation_p.S188C|NKIRAS2_ENST00000316082.4_Missense_Mutation_p.S226C|NKIRAS2_ENST00000393881.3_Missense_Mutation_p.S188C|NKIRAS2_ENST00000479407.1_3'UTR|NKIRAS2_ENST00000393885.4_Missense_Mutation_p.S188C|NKIRAS2_ENST00000449471.4_Missense_Mutation_p.S132C	NM_001001349.2	NP_001001349.1	Q9NYR9	KBRS2_HUMAN	NFKB inhibitor interacting Ras-like 2	188	Small GTPase-like.				I-kappaB kinase/NF-kappaB cascade|small GTPase mediated signal transduction	cytoplasm	GTP binding|GTPase activity			large_intestine(2)|lung(5)|ovary(1)|upper_aerodigestive_tract(1)	9		all_cancers(22;1.1e-05)|Breast(137;0.000143)|all_epithelial(22;0.000319)				GGCAGCGGCTCCTTGGATGGC	0.582000													3	49					0	0	1	0	0
SLC1A5	6510	broad.mit.edu	37	19	47280252	47280252	+	Silent	SNP	G	G	T			TCGA-ZF-AA5P-01A-11D-A391-08	TCGA-ZF-AA5P-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0fec8a1-76ee-40a1-80c5-4cf8ab5540c6	9375b535-87d5-4b4e-81ab-8986e4e1dce3	g.chr19:47280252G>T	ENST00000542575.2	-	7	1996	c.1368C>A	c.(1366-1368)atC>atA	p.I456I	SLC1A5_ENST00000412532.2_Silent_p.I228I|SLC1A5_ENST00000434726.2_Silent_p.I254I|SLC1A5_ENST00000594991.1_Silent_p.I280I	NM_005628.2	NP_005619.1	Q15758	AAAT_HUMAN	solute carrier family 1 (neutral amino acid transporter), member 5	456					cellular nitrogen compound metabolic process	integral to plasma membrane|melanosome|membrane fraction	neutral amino acid transmembrane transporter activity|protein binding|receptor activity|sodium:dicarboxylate symporter activity			cervix(1)|endometrium(3)|kidney(3)|large_intestine(3)|lung(2)|stomach(1)	13		all_epithelial(76;0.00314)|Ovarian(192;0.0798)|all_neural(266;0.107)		OV - Ovarian serous cystadenocarcinoma(262;0.000338)|all cancers(93;0.000882)|Epithelial(262;0.0211)|GBM - Glioblastoma multiforme(486;0.0341)	L-Asparagine(DB00174)|L-Glutamine(DB00130)	CCACAGCCAGGATCAAGGAGA	0.617000													5	34					0.0293803	0.030318	1	1	0
CLIP1	6249	broad.mit.edu	37	12	122864955	122864955	+	Silent	SNP	G	G	A			TCGA-ZF-AA5P-01A-11D-A391-08	TCGA-ZF-AA5P-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0fec8a1-76ee-40a1-80c5-4cf8ab5540c6	9375b535-87d5-4b4e-81ab-8986e4e1dce3	g.chr12:122864955G>A	ENST00000358808.2	-	2	199	c.45C>T	c.(43-45)atC>atT	p.I15I	CLIP1_ENST00000361654.4_Silent_p.I15I|CLIP1_ENST00000537178.1_Silent_p.I15I|CLIP1_ENST00000540338.1_Silent_p.I15I|CLIP1_ENST00000302528.7_Silent_p.I15I	NM_001247997.1|NM_002956.2	NP_001234926.1|NP_002947.1	P30622	CLIP1_HUMAN	CAP-GLY domain containing linker protein 1	15					mitotic prometaphase|positive regulation of microtubule polymerization	centrosome|cytosol|endosome|intermediate filament|kinetochore	nucleic acid binding|protein homodimerization activity|zinc ion binding			NS(1)|breast(5)|endometrium(4)|kidney(5)|large_intestine(16)|liver(1)|lung(21)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	60	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.81e-05)|Epithelial(86;6.85e-05)|BRCA - Breast invasive adenocarcinoma(302;0.226)		CAGGCTTCAGGATCTTGGTGG	0.438000													6	80					0	0	1	0	0
CHD8	57680	broad.mit.edu	37	14	21869112	21869112	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-AA5P-01A-11D-A391-08	TCGA-ZF-AA5P-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0fec8a1-76ee-40a1-80c5-4cf8ab5540c6	9375b535-87d5-4b4e-81ab-8986e4e1dce3	g.chr14:21869112C>A	ENST00000399982.2	-	21	4356	c.4292G>T	c.(4291-4293)cGc>cTc	p.R1431L	CHD8_ENST00000557364.1_Missense_Mutation_p.R1431L|CHD8_ENST00000555962.1_Intron|CHD8_ENST00000430710.3_Missense_Mutation_p.R1152L	NM_001170629.1	NP_001164100.1	Q9HCK8	CHD8_HUMAN	chromodomain helicase DNA binding protein 8	1431					ATP-dependent chromatin remodeling|canonical Wnt receptor signaling pathway|negative regulation of transcription, DNA-dependent|negative regulation of Wnt receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase III promoter|transcription, DNA-dependent	MLL1 complex	ATP binding|beta-catenin binding|DNA binding|DNA helicase activity|DNA-dependent ATPase activity|methylated histone residue binding|p53 binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(4)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(8)|lung(33)|ovary(6)|prostate(7)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	85	all_cancers(95;0.00121)		Epithelial(56;2.55e-06)|all cancers(55;1.73e-05)	GBM - Glioblastoma multiforme(265;0.00424)		TCTGCGGGAGCGTGGCCGCTC	0.498000													9	52					0.307466	0.307466	1	1	0
SF3B1	23451	broad.mit.edu	37	2	198265467	198265467	+	Missense_Mutation	SNP	A	A	C			TCGA-ZF-AA5P-01A-11D-A391-08	TCGA-ZF-AA5P-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0fec8a1-76ee-40a1-80c5-4cf8ab5540c6	9375b535-87d5-4b4e-81ab-8986e4e1dce3	g.chr2:198265467A>C	ENST00000335508.6	-	18	2781	c.2690T>G	c.(2689-2691)cTt>cGt	p.L897R		NM_012433.2	NP_036565.2	O75533	SF3B1_HUMAN	splicing factor 3b, subunit 1, 155kDa						nuclear mRNA splicing, via spliceosome	catalytic step 2 spliceosome|nuclear speck|U12-type spliceosomal complex	protein binding			NS(35)|breast(10)|central_nervous_system(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(524)|kidney(4)|large_intestine(10)|lung(19)|ovary(1)|pancreas(4)|prostate(6)|salivary_gland(1)|skin(4)|testis(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	633			OV - Ovarian serous cystadenocarcinoma(117;0.246)			GAAAGCATAAAGAATACCATC	0.323000			Mis		myelodysplastic syndrome								3	43					0	0	1	0	0
LPPR5	163404	broad.mit.edu	37	1	99422173	99422173	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-AA5P-01A-11D-A391-08	TCGA-ZF-AA5P-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0fec8a1-76ee-40a1-80c5-4cf8ab5540c6	9375b535-87d5-4b4e-81ab-8986e4e1dce3	g.chr1:99422173C>A	ENST00000370188.3	-	2	722	c.362G>T	c.(361-363)cGa>cTa	p.R121L	LPPR5_ENST00000263177.4_Missense_Mutation_p.R121L	NM_001010861.2	NP_001010861.1	Q32ZL2	LPPR5_HUMAN		121						integral to membrane	hydrolase activity										ACCAAGAAATCGGACAGTTCG	0.353000													4	20					0.00909568	0.0096954	1	1	0
MAB21L3	126868	broad.mit.edu	37	1	116675774	116675774	+	Missense_Mutation	SNP	G	G	A	rs150571972		TCGA-ZF-AA5P-01A-11D-A391-08	TCGA-ZF-AA5P-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0fec8a1-76ee-40a1-80c5-4cf8ab5540c6	9375b535-87d5-4b4e-81ab-8986e4e1dce3	g.chr1:116675774G>A	ENST00000369500.3	+	7	1142	c.877G>A	c.(877-879)Gag>Aag	p.E293K		NM_152367.2	NP_689580.2	Q8N8X9	MB213_HUMAN	mab-21-like 3 (C. elegans)	293										breast(2)|endometrium(1)|large_intestine(3)|lung(8)|prostate(2)|skin(2)|urinary_tract(1)	19						TTGGACCTGCGAGAAATATCC	0.478000													4	51					0	0	1	0	0
MOCS1	4337	broad.mit.edu	37	6	39895256	39895256	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA5P-01A-11D-A391-08	TCGA-ZF-AA5P-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0fec8a1-76ee-40a1-80c5-4cf8ab5540c6	9375b535-87d5-4b4e-81ab-8986e4e1dce3	g.chr6:39895256G>A	ENST00000373186.4	-	1	199	c.62C>T	c.(61-63)cCt>cTt	p.P21L	MOCS1_ENST00000373195.3_Intron|MOCS1_ENST00000373188.2_Intron|MOCS1_ENST00000432280.2_Intron|MOCS1_ENST00000308559.7_Intron|MOCS1_ENST00000425303.2_Missense_Mutation_p.P21L|MOCS1_ENST00000373175.4_Intron|MOCS1_ENST00000340692.5_Intron	NM_005943.5	NP_005934.2	Q9NZB8	MOCS1_HUMAN	molybdenum cofactor synthesis 1	0	Molybdenum cofactor biosynthesis protein A.				Mo-molybdopterin cofactor biosynthetic process|water-soluble vitamin metabolic process	cytosol|molybdopterin synthase complex|nucleus	4 iron, 4 sulfur cluster binding|catalytic activity|GTP binding|metal ion binding			central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(1)|liver(2)|lung(6)|ovary(1)|pancreas(1)|prostate(1)|skin(2)	21	Ovarian(28;0.0355)|Colorectal(47;0.196)					AGAGGCACAAGGAGAACCGCC	0.622000													9	34					0	0	1	0	0
AIM1L	55057	broad.mit.edu	37	1	26655281	26655281	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA5P-01A-11D-A391-08	TCGA-ZF-AA5P-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0fec8a1-76ee-40a1-80c5-4cf8ab5540c6	9375b535-87d5-4b4e-81ab-8986e4e1dce3	g.chr1:26655281G>C	ENST00000527815.1	-	15	1825	c.1776C>G	c.(1774-1776)agC>agG	p.S592R	AIM1L_ENST00000308182.5_Missense_Mutation_p.S421R	NM_001039775.3	NP_001034864.2	Q8N1P7	AIM1L_HUMAN	absent in melanoma 1-like	421	Ricin B-type lectin.						sugar binding			endometrium(2)|kidney(2)|large_intestine(1)|lung(4)|pancreas(1)|skin(2)	12		all_cancers(24;4.67e-25)|Colorectal(325;3.46e-05)|all_lung(284;5.94e-05)|Lung NSC(340;7.26e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.00637)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;1.51e-27)|Colorectal(126;1.61e-08)|COAD - Colon adenocarcinoma(152;9.32e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.000792)|BRCA - Breast invasive adenocarcinoma(304;0.00104)|STAD - Stomach adenocarcinoma(196;0.00154)|GBM - Glioblastoma multiforme(114;0.00858)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.165)|LUSC - Lung squamous cell carcinoma(448;0.239)		CGGCTTGCAGGCTCCGCACCT	0.612000													5	73					0	0	1	0	0
HTATSF1	27336	broad.mit.edu	37	X	135592283	135592283	+	Nonsense_Mutation	SNP	G	G	T			TCGA-ZF-AA5P-01A-11D-A391-08	TCGA-ZF-AA5P-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0fec8a1-76ee-40a1-80c5-4cf8ab5540c6	9375b535-87d5-4b4e-81ab-8986e4e1dce3	g.chrX:135592283G>T	ENST00000535601.1	+	9	1389	c.967G>T	c.(967-969)Gag>Tag	p.E323*	HTATSF1_ENST00000218364.4_Nonsense_Mutation_p.E323*	NM_001163280.1	NP_001156752.1	O43719	HTSF1_HUMAN	HIV-1 Tat specific factor 1	323	RRM 2.				regulation of transcription elongation, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent|viral genome replication	nucleus	nucleotide binding|protein binding|RNA binding			NS(1)|biliary_tract(1)|breast(2)|endometrium(1)|kidney(2)|large_intestine(5)|lung(14)|ovary(3)|prostate(1)	30	Acute lymphoblastic leukemia(192;0.000127)					TCGGGATCCAGAGGAAGCTGA	0.418000													14	110					1.52009e-12	1.84311e-12	1	1	0
APLF	200558	broad.mit.edu	37	2	68729889	68729889	+	Silent	SNP	G	G	A			TCGA-ZF-AA5P-01A-11D-A391-08	TCGA-ZF-AA5P-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0fec8a1-76ee-40a1-80c5-4cf8ab5540c6	9375b535-87d5-4b4e-81ab-8986e4e1dce3	g.chr2:68729889G>A	ENST00000303795.4	+	3	366	c.195G>A	c.(193-195)caG>caA	p.Q65Q		NM_173545.2	NP_775816.1	Q8IW19	APLF_HUMAN	aprataxin and PNKP like factor	65	FHA-like.				double-strand break repair|single strand break repair	cytosol|nucleus	3'-5' exonuclease activity|DNA-(apurinic or apyrimidinic site) lyase activity|endodeoxyribonuclease activity|metal ion binding|nucleotide binding|protein binding			autonomic_ganglia(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(5)|liver(2)|lung(9)|ovary(3)|prostate(1)|skin(1)	25						GTTTTTACCAGTCTTCAGAGA	0.284000													8	94					0	0	1	0	0
FNIP1	96459	broad.mit.edu	37	5	131007605	131007605	+	Silent	SNP	G	G	A	rs139857435		TCGA-ZF-AA5P-01A-11D-A391-08	TCGA-ZF-AA5P-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0fec8a1-76ee-40a1-80c5-4cf8ab5540c6	9375b535-87d5-4b4e-81ab-8986e4e1dce3	g.chr5:131007605G>A	ENST00000307968.7	-	13	2447	c.2448C>T	c.(2446-2448)atC>atT	p.I816I	FNIP1_ENST00000510461.1_Silent_p.I844I|CTC-432M15.3_ENST00000514667.1_Intron|FNIP1_ENST00000307954.8_Silent_p.I799I	NM_001008738.2	NP_001008738			folliculin interacting protein 1											NS(1)|breast(1)|endometrium(5)|kidney(3)|large_intestine(4)|lung(11)|ovary(2)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	34		all_cancers(142;0.00347)|Lung NSC(810;0.106)|all_lung(232;0.123)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	Lung(113;0.0665)		TCCTGGTTTCGATTGAATCAT	0.343000													4	94					0	0	1	0	0
BAHCC1	57597	broad.mit.edu	37	17	79426564	79426564	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA5P-01A-11D-A391-08	TCGA-ZF-AA5P-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0fec8a1-76ee-40a1-80c5-4cf8ab5540c6	9375b535-87d5-4b4e-81ab-8986e4e1dce3	g.chr17:79426564G>A	ENST00000307745.7	+	27	5839	c.5839G>A	c.(5839-5841)Ggc>Agc	p.G1947S																								CCTCCCGCCCGGCACGCGGGT	0.687000													3	51					0	0	1	0	0
DDX19A	55308	broad.mit.edu	37	16	70398974	70398974	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA5P-01A-11D-A391-08	TCGA-ZF-AA5P-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0fec8a1-76ee-40a1-80c5-4cf8ab5540c6	9375b535-87d5-4b4e-81ab-8986e4e1dce3	g.chr16:70398974G>C	ENST00000302243.7	+	7	707	c.544G>C	c.(544-546)Gag>Cag	p.E182Q	DDX19A_ENST00000417604.2_Missense_Mutation_p.E151Q|DDX19A_ENST00000443119.2_Missense_Mutation_p.E92Q|RP11-529K1.3_ENST00000567706.1_Intron	NM_018332.3	NP_060802.1			DEAD (Asp-Glu-Ala-Asp) box polypeptide 19A											breast(1)|endometrium(1)|large_intestine(5)|lung(3)|urinary_tract(1)	11		Ovarian(137;0.221)				AAAAGTGATTGAGCAGATGGG	0.468000													6	102					0	0	1	0	0
RERE	473	broad.mit.edu	37	1	8716245	8716245	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA5P-01A-11D-A391-08	TCGA-ZF-AA5P-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0fec8a1-76ee-40a1-80c5-4cf8ab5540c6	9375b535-87d5-4b4e-81ab-8986e4e1dce3	g.chr1:8716245G>A	ENST00000337907.3	-	3	746	c.112C>T	c.(112-114)Cgc>Tgc	p.R38C	RERE_ENST00000400908.2_Missense_Mutation_p.R38C|RERE_ENST00000400907.2_Missense_Mutation_p.R38C	NM_012102.3	NP_036234.3	Q9P2R6	RERE_HUMAN	arginine-glutamic acid dipeptide (RE) repeats	38					multicellular organismal development|NLS-bearing substrate import into nucleus	mitochondrion	poly-glutamine tract binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(1)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(5)|liver(1)|lung(16)|ovary(3)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	49	Ovarian(185;0.0661)	all_epithelial(116;1.17e-21)|all_lung(118;1.4e-06)|Lung NSC(185;3.06e-06)|Renal(390;0.000147)|Breast(348;0.000206)|Colorectal(325;0.00187)|Hepatocellular(190;0.00825)|Ovarian(437;0.0253)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;9.64e-67)|GBM - Glioblastoma multiforme(8;9.89e-33)|Colorectal(212;1.45e-07)|COAD - Colon adenocarcinoma(227;3.42e-05)|Kidney(185;6e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000533)|KIRC - Kidney renal clear cell carcinoma(229;0.00106)|STAD - Stomach adenocarcinoma(132;0.00118)|READ - Rectum adenocarcinoma(331;0.0419)|Lung(427;0.195)		CAGCTCCGGCGTGGCCTTGAA	0.502000													4	167					0	0	1	0	0
TMEM200A	114801	broad.mit.edu	37	6	130762006	130762006	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA5P-01A-11D-A391-08	TCGA-ZF-AA5P-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0fec8a1-76ee-40a1-80c5-4cf8ab5540c6	9375b535-87d5-4b4e-81ab-8986e4e1dce3	g.chr6:130762006C>G	ENST00000392429.1	+	2	2817	c.439C>G	c.(439-441)Ctt>Gtt	p.L147V	TMEM200A_ENST00000545622.1_Missense_Mutation_p.L147V|TMEM200A_ENST00000296978.3_Missense_Mutation_p.L147V	NM_052913.2	NP_443145.1	Q86VY9	T200A_HUMAN	transmembrane protein 200A	147						integral to membrane				NS(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(30)|ovary(1)|prostate(4)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	52				GBM - Glioblastoma multiforme(226;0.0139)|OV - Ovarian serous cystadenocarcinoma(155;0.12)		TAATGCCATTCTTCATGAAAA	0.403000													5	85					0	0	1	0	0
SPTA1	6708	broad.mit.edu	37	1	158617418	158617418	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-AA5P-01A-11D-A391-08	TCGA-ZF-AA5P-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0fec8a1-76ee-40a1-80c5-4cf8ab5540c6	9375b535-87d5-4b4e-81ab-8986e4e1dce3	g.chr1:158617418C>A	ENST00000368147.4	-	27	3987	c.3807G>T	c.(3805-3807)gaG>gaT	p.E1269D		NM_003126.2	NP_003117.2	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1 (elliptocytosis 2)						actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			NS(3)|breast(7)|cervix(1)|endometrium(22)|kidney(9)|large_intestine(29)|liver(2)|lung(183)|ovary(5)|prostate(18)|skin(11)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(6)	307	all_hematologic(112;0.0378)					CTTCCCAGGCCTCATTCAGCT	0.567000													6	52					0.0215528	0.0224798	1	1	0
ASXL1	171023	broad.mit.edu	37	20	31024799	31024799	+	Silent	SNP	T	T	G			TCGA-ZF-AA5P-01A-11D-A391-08	TCGA-ZF-AA5P-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0fec8a1-76ee-40a1-80c5-4cf8ab5540c6	9375b535-87d5-4b4e-81ab-8986e4e1dce3	g.chr20:31024799T>G	ENST00000375687.4	+	13	4708	c.4284T>G	c.(4282-4284)tcT>tcG	p.S1428S	ASXL1_ENST00000306058.5_Silent_p.S1423S	NM_015338.5	NP_056153	Q8IXJ9	ASXL1_HUMAN	additional sex combs like 1 (Drosophila)	1428					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	PR-DUB complex	metal ion binding|protein binding			NS(1)|breast(2)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(655)|kidney(5)|large_intestine(18)|liver(1)|lung(27)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	722						TGGAGCCTTCTTCTCTCCCCT	0.517000			"""F, N, Mis"""		"""MDS, CMML"""								5	123					0	0	1	0	0
ADAMTS9	56999	broad.mit.edu	37	3	64617153	64617153	+	Silent	SNP	T	T	C			TCGA-ZF-AA5P-01A-11D-A391-08	TCGA-ZF-AA5P-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0fec8a1-76ee-40a1-80c5-4cf8ab5540c6	9375b535-87d5-4b4e-81ab-8986e4e1dce3	g.chr3:64617153T>C	ENST00000498707.1	-	16	2709	c.2367A>G	c.(2365-2367)gaA>gaG	p.E789E	ADAMTS9_ENST00000295903.4_Silent_p.E761E	NM_182920.1	NP_891550.1	Q9P2N4	ATS9_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 9	789	Spacer.				glycoprotein catabolic process|multicellular organismal development|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			breast(3)|central_nervous_system(4)|cervix(1)|endometrium(9)|kidney(4)|large_intestine(17)|liver(4)|lung(43)|ovary(3)|prostate(3)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	100		Lung NSC(201;0.00682)		BRCA - Breast invasive adenocarcinoma(55;0.00142)|Kidney(15;0.00202)|KIRC - Kidney renal clear cell carcinoma(15;0.00221)		CATCGTCTGTTTCCCCTGAGA	0.468000													4	143					0	0	1	0	0
WIZ	58525	broad.mit.edu	37	19	15537969	15537969	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA5P-01A-11D-A391-08	TCGA-ZF-AA5P-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0fec8a1-76ee-40a1-80c5-4cf8ab5540c6	9375b535-87d5-4b4e-81ab-8986e4e1dce3	g.chr19:15537969G>A	ENST00000389282.4	-	6	3689	c.3476C>T	c.(3475-3477)aCg>aTg	p.T1159M	WIZ_ENST00000263381.7_Missense_Mutation_p.T302M|WIZ_ENST00000599910.2_Missense_Mutation_p.T476M|WIZ_ENST00000599686.3_Missense_Mutation_p.T343M|WIZ_ENST00000545156.1_Missense_Mutation_p.T473M			O95785	WIZ_HUMAN	widely interspaced zinc finger motifs	1159	Pro-rich.					nucleus	zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(9)|ovary(1)|skin(1)|stomach(1)|urinary_tract(1)	24						CTTTCGGGCCGTAGGAGGAGG	0.632000													3	39					0	0	1	0	0
CDX2	1045	broad.mit.edu	37	13	28542657	28542657	+	Silent	SNP	G	G	T			TCGA-ZF-AA5P-01A-11D-A391-08	TCGA-ZF-AA5P-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0fec8a1-76ee-40a1-80c5-4cf8ab5540c6	9375b535-87d5-4b4e-81ab-8986e4e1dce3	g.chr13:28542657G>T	ENST00000381020.7	-	1	2619	c.487C>A	c.(487-489)Cgg>Agg	p.R163R		NM_001265.4	NP_001256.3	Q99626	CDX2_HUMAN	caudal type homeobox 2	163					organ morphogenesis|transcription from RNA polymerase II promoter		sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(2)|large_intestine(1)|lung(6)	9	all_cancers(110;0.191)|all_hematologic(3;0.0447)|Acute lymphoblastic leukemia(6;0.155)	Lung SC(185;0.0156)	Colorectal(13;0.000157)|READ - Rectum adenocarcinoma(15;0.105)	GBM - Glioblastoma multiforme(144;0.0407)|all cancers(112;0.0491)|OV - Ovarian serous cystadenocarcinoma(117;0.199)		CACAGGTTCCGCCGCTGGCCG	0.726000			T	ETV6	AML								4	16					0.000602214	0.000671434	1	1	0
LAMB4	22798	broad.mit.edu	37	7	107703305	107703305	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA5P-01A-11D-A391-08	TCGA-ZF-AA5P-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0fec8a1-76ee-40a1-80c5-4cf8ab5540c6	9375b535-87d5-4b4e-81ab-8986e4e1dce3	g.chr7:107703305C>G	ENST00000388781.3	-	23	3279	c.3196G>C	c.(3196-3198)Gat>Cat	p.D1066H	LAMB4_ENST00000205386.4_Missense_Mutation_p.D1066H|LAMB4_ENST00000388780.3_Missense_Mutation_p.D1066H	NM_007356.2	NP_031382.2	A4D0S4	LAMB4_HUMAN	laminin, beta 4	1066	Laminin EGF-like 11.				cell adhesion	basement membrane				NS(1)|breast(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(22)|lung(40)|ovary(4)|prostate(5)|skin(4)	97						CAGTATCCATCAGCACAACGG	0.557000													3	29					0	0	1	0	0
NCR2	9436	broad.mit.edu	37	6	41318501	41318501	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA5P-01A-11D-A391-08	TCGA-ZF-AA5P-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0fec8a1-76ee-40a1-80c5-4cf8ab5540c6	9375b535-87d5-4b4e-81ab-8986e4e1dce3	g.chr6:41318501C>T	ENST00000373089.5	+	5	818	c.730C>T	c.(730-732)Ctt>Ttt	p.L244F	NCR2_ENST00000373086.3_3'UTR|NCR2_ENST00000373083.4_3'UTR	NM_004828.3	NP_004819.2	O95944	NCTR2_HUMAN	natural cytotoxicity triggering receptor 2	244					cellular defense response	integral to plasma membrane	transmembrane receptor activity			NS(1)|breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(3)|ovary(1)|urinary_tract(1)	14	Ovarian(28;0.0327)|Colorectal(47;0.196)					ggtcacggaccttccctggac	0.483000													5	39					0	0	1	0	0
FAM193A	8603	broad.mit.edu	37	4	2691313	2691313	+	Silent	SNP	G	G	A			TCGA-ZF-AA5P-01A-11D-A391-08	TCGA-ZF-AA5P-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0fec8a1-76ee-40a1-80c5-4cf8ab5540c6	9375b535-87d5-4b4e-81ab-8986e4e1dce3	g.chr4:2691313G>A	ENST00000324666.5	+	12	1890	c.1539G>A	c.(1537-1539)ccG>ccA	p.P513P	FAM193A_ENST00000382839.3_Silent_p.P513P|FAM193A_ENST00000502458.1_Silent_p.P535P|FAM193A_ENST00000505311.1_Silent_p.P513P|FAM193A_ENST00000545951.1_Silent_p.P513P	NM_001256666.1	NP_001243595.1	P78312	F193A_HUMAN	family with sequence similarity 193, member A	513										NS(2)|breast(1)|endometrium(4)|kidney(4)|large_intestine(3)|lung(12)|ovary(4)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(3)	40						ATATTTATCCGAGCTGTTTTG	0.373000													5	82					0	0	1	0	0
TRBV10-1	28585	broad.mit.edu	37	7	142231710	142231710	+	RNA	SNP	A	A	G			TCGA-ZF-AA5P-01A-11D-A391-08	TCGA-ZF-AA5P-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0fec8a1-76ee-40a1-80c5-4cf8ab5540c6	9375b535-87d5-4b4e-81ab-8986e4e1dce3	g.chr7:142231710A>G	ENST00000390364.3	-	0	274																											CGTGAACACCATATGAGTAAT	0.512000													19	131					0	0	1	0	0
OR51B5	282763	broad.mit.edu	37	11	5364578	5364578	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA5P-01A-11D-A391-08	TCGA-ZF-AA5P-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0fec8a1-76ee-40a1-80c5-4cf8ab5540c6	9375b535-87d5-4b4e-81ab-8986e4e1dce3	g.chr11:5364578G>C	ENST00000300773.2	-	1	231	c.177C>G	c.(175-177)ttC>ttG	p.F59L	HBG2_ENST00000380252.1_Intron|HBG2_ENST00000380259.2_Intron|AC104389.28_ENST00000415970.1_RNA|HBE1_ENST00000380237.1_Intron	NM_001005567.2	NP_001005567.2	Q9H339	O51B5_HUMAN	olfactory receptor, family 51, subfamily B, member 5	59					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(13)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)	28		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;3.05e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TGGCCAGAAAGAAGTACATGG	0.507000													3	29					0	0	1	0	0
SOS2	6655	broad.mit.edu	37	14	50666491	50666491	+	Missense_Mutation	SNP	T	T	G			TCGA-ZF-AA5P-01A-11D-A391-08	TCGA-ZF-AA5P-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0fec8a1-76ee-40a1-80c5-4cf8ab5540c6	9375b535-87d5-4b4e-81ab-8986e4e1dce3	g.chr14:50666491T>G	ENST00000216373.5	-	4	702	c.428A>C	c.(427-429)aAa>aCa	p.K143T	SOS2_ENST00000543680.1_Missense_Mutation_p.K143T	NM_006939.2	NP_008870.2	Q07890	SOS2_HUMAN	son of sevenless homolog 2 (Drosophila)	143					apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	DNA binding|protein binding|Rho guanyl-nucleotide exchange factor activity			cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(13)|lung(16)|ovary(2)|skin(1)	39	all_epithelial(31;0.000822)|Breast(41;0.0065)					ACCAGCCAATTTTAAAATATC	0.338000													8	137					0	0	1	0	0
ZNF439	90594	broad.mit.edu	37	19	11978488	11978488	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA5P-01A-11D-A391-08	TCGA-ZF-AA5P-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0fec8a1-76ee-40a1-80c5-4cf8ab5540c6	9375b535-87d5-4b4e-81ab-8986e4e1dce3	g.chr19:11978488C>G	ENST00000304030.2	+	3	804	c.604C>G	c.(604-606)Caa>Gaa	p.Q202E	ZNF439_ENST00000455282.1_Missense_Mutation_p.Q66E|ZNF439_ENST00000592534.1_Intron	NM_152262.2	NP_689475.1	Q8NDP4	ZN439_HUMAN	zinc finger protein 439	202					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(7)|pancreas(1)|skin(2)	27						TTCAAGCATTCAAAGACACAT	0.378000													8	178					0	0	1	0	0
ADAMTS12	81792	broad.mit.edu	37	5	33527306	33527306	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA5P-01A-11D-A391-08	TCGA-ZF-AA5P-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0fec8a1-76ee-40a1-80c5-4cf8ab5540c6	9375b535-87d5-4b4e-81ab-8986e4e1dce3	g.chr5:33527306G>A	ENST00000504830.1	-	24	5107	c.4772C>T	c.(4771-4773)tCa>tTa	p.S1591L	ADAMTS12_ENST00000352040.3_Missense_Mutation_p.S1506L	NM_030955.2	NP_112217.2	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 12	1591			S -> P (in dbSNP:rs16891281).		proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(7)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(11)|large_intestine(31)|liver(1)|lung(135)|ovary(4)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(5)	216						GAGTTCTTTTGACTTTTGGAG	0.537000										HNSCC(64;0.19)			4	160					0	0	1	0	0
SLC1A5	6510	broad.mit.edu	37	19	47280509	47280509	+	Silent	SNP	G	G	A			TCGA-ZF-AA5P-01A-11D-A391-08	TCGA-ZF-AA5P-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0fec8a1-76ee-40a1-80c5-4cf8ab5540c6	9375b535-87d5-4b4e-81ab-8986e4e1dce3	g.chr19:47280509G>A	ENST00000542575.2	-	6	1840	c.1212C>T	c.(1210-1212)ctC>ctT	p.L404L	SLC1A5_ENST00000412532.2_Silent_p.L176L|SLC1A5_ENST00000434726.2_Silent_p.L202L|SLC1A5_ENST00000594991.1_Silent_p.L228L	NM_005628.2	NP_005619.1	Q15758	AAAT_HUMAN	solute carrier family 1 (neutral amino acid transporter), member 5	404					cellular nitrogen compound metabolic process	integral to plasma membrane|melanosome|membrane fraction	neutral amino acid transmembrane transporter activity|protein binding|receptor activity|sodium:dicarboxylate symporter activity			cervix(1)|endometrium(3)|kidney(3)|large_intestine(3)|lung(2)|stomach(1)	13		all_epithelial(76;0.00314)|Ovarian(192;0.0798)|all_neural(266;0.107)		OV - Ovarian serous cystadenocarcinoma(262;0.000338)|all cancers(93;0.000882)|Epithelial(262;0.0211)|GBM - Glioblastoma multiforme(486;0.0341)	L-Asparagine(DB00174)|L-Glutamine(DB00130)	ACTGCTGGCTGAGCTGTGCAA	0.612000													7	34					0	0	1	0	0
RLF	6018	broad.mit.edu	37	1	40702659	40702659	+	Missense_Mutation	SNP	A	A	G			TCGA-ZF-AA5P-01A-11D-A391-08	TCGA-ZF-AA5P-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0fec8a1-76ee-40a1-80c5-4cf8ab5540c6	9375b535-87d5-4b4e-81ab-8986e4e1dce3	g.chr1:40702659A>G	ENST00000372771.4	+	8	2312	c.2285A>G	c.(2284-2286)cAt>cGt	p.H762R		NM_012421.3	NP_036553.2	Q13129	RLF_HUMAN	rearranged L-myc fusion	762					chromosome organization|DNA integration|DNA mediated transformation|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(11)|kidney(4)|large_intestine(18)|lung(18)|ovary(2)|pancreas(1)|prostate(2)|skin(1)|stomach(4)|urinary_tract(2)	68	Lung NSC(20;4.38e-06)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;5.87e-19)|Epithelial(16;7.02e-16)|all cancers(16;1.69e-14)|Lung(16;0.0427)|LUSC - Lung squamous cell carcinoma(16;0.0461)			CTACTTAACCATAAACAAAAG	0.398000													9	109					0	0	1	0	0
LOC101927060	101927060	broad.mit.edu	37	17	45128792	45128792	+	RNA	SNP	G	G	T	rs143713325	by1000genomes	TCGA-ZF-AA5P-01A-11D-A391-08	TCGA-ZF-AA5P-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0fec8a1-76ee-40a1-80c5-4cf8ab5540c6	9375b535-87d5-4b4e-81ab-8986e4e1dce3	g.chr17:45128792G>T	ENST00000575173.1	-	0	418																											AATTCAGGTTGTCAGAATGCA	0.373000													3	44					0.004672	0.00503538	1	1	0
CDK3	1018	broad.mit.edu	37	17	73999335	73999335	+	Silent	SNP	T	T	C			TCGA-ZF-AA5P-01A-11D-A391-08	TCGA-ZF-AA5P-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0fec8a1-76ee-40a1-80c5-4cf8ab5540c6	9375b535-87d5-4b4e-81ab-8986e4e1dce3	g.chr17:73999335T>C	ENST00000425876.2	+	6	736	c.648T>C	c.(646-648)ttT>ttC	p.F216F	TEN1-CDK3_ENST00000567351.1_RNA|CDK3_ENST00000448471.1_Silent_p.F216F			Q00526	CDK3_HUMAN	cyclin-dependent kinase 3	216	Protein kinase.				cell division|cell proliferation|mitosis		ATP binding|cyclin-dependent protein kinase activity			central_nervous_system(1)	1						TTCGTATCTTTCGTATGCTGG	0.552000													26	161					0	0	1	0	0
ETV4	2118	broad.mit.edu	37	17	41610249	41610249	+	Missense_Mutation	SNP	G	G	A	rs144213199		TCGA-ZF-AA5P-01A-11D-A391-08	TCGA-ZF-AA5P-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0fec8a1-76ee-40a1-80c5-4cf8ab5540c6	9375b535-87d5-4b4e-81ab-8986e4e1dce3	g.chr17:41610249G>A	ENST00000319349.5	-	8	902	c.604C>T	c.(604-606)Cgg>Tgg	p.R202W	ETV4_ENST00000591713.1_Missense_Mutation_p.R202W|ETV4_ENST00000545954.1_Missense_Mutation_p.R163W|ETV4_ENST00000538265.1_Missense_Mutation_p.R163W|ETV4_ENST00000545089.1_Missense_Mutation_p.R148W|ETV4_ENST00000393664.2_Missense_Mutation_p.R202W	NM_001079675.2	NP_001073143.1	P43268	ETV4_HUMAN	ets variant 4	202	Gln-rich.				positive regulation of transcription, DNA-dependent	nucleolus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		EWSR1/ETV4(6)|CANT1/ETV4(3)|TMPRSS2/ETV4(13)|DDX5_ENST00000540698/ETV4(2)|KLK2/ETV4(2)	ovary(2)|upper_aerodigestive_tract(1)	3		Breast(137;0.00908)		BRCA - Breast invasive adenocarcinoma(366;0.0798)		AGGGGTTCCCGGCCCCCTCCC	0.567000			T	"""EWSR1, TMPRSS2, DDX5, KLK2, CANT1"""	"""Ewing sarcoma, Prostate carcinoma"""								13	53					0	0	1	0	0
IGHG2	3501	broad.mit.edu	37	14	106110079	106110079	+	RNA	SNP	C	C	T			TCGA-ZF-AA5P-01A-11D-A391-08	TCGA-ZF-AA5P-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0fec8a1-76ee-40a1-80c5-4cf8ab5540c6	9375b535-87d5-4b4e-81ab-8986e4e1dce3	g.chr14:106110079C>T	ENST00000390545.2	-	0	538																											GCTGACCACACGGAACGTGCT	0.587000													14	279					0	0	1	0	0
TCHH	7062	broad.mit.edu	37	1	152081414	152081414	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA5P-01A-11D-A391-08	TCGA-ZF-AA5P-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0fec8a1-76ee-40a1-80c5-4cf8ab5540c6	9375b535-87d5-4b4e-81ab-8986e4e1dce3	g.chr1:152081414C>G	ENST00000368804.1	-	2	4278	c.4279G>C	c.(4279-4281)Gag>Cag	p.E1427Q		NM_007113.2	NP_009044.2	Q07283	TRHY_HUMAN	trichohyalin	1427	23 X 26 AA approximate tandem repeats.				keratinization	cytoskeleton	calcium ion binding			NS(2)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(20)|kidney(9)|large_intestine(16)|lung(33)|ovary(3)|pancreas(1)|prostate(4)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(4)	105	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CTGTCACGCTCTTGGCGGCTC	0.597000											OREG0031687	type=REGULATORY REGION|TFbs=RELA|Dataset=RELA (p65) ChIP-PET Binding Sites|EvidenceSubtype=Chromatin immunoprecipitation with paired-end diTag sequencing (ChIP-PET)	5	149					0	0	1	0	0
PLEKHM1	9842	broad.mit.edu	37	17	43522967	43522967	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA5P-01A-11D-A391-08	TCGA-ZF-AA5P-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0fec8a1-76ee-40a1-80c5-4cf8ab5540c6	9375b535-87d5-4b4e-81ab-8986e4e1dce3	g.chr17:43522967C>G	ENST00000430334.3	-	9	2839	c.2706G>C	c.(2704-2706)caG>caC	p.Q902H	PLEKHM1_ENST00000580404.1_5'UTR|PLEKHM1_ENST00000421073.2_Missense_Mutation_p.Q813H	NM_014798.2	NP_055613.1	Q9Y4G2	PKHM1_HUMAN	pleckstrin homology domain containing, family M (with RUN domain) member 1	902					intracellular signal transduction	cytoplasm	metal ion binding	p.Q902Q(1)		breast(1)|central_nervous_system(1)|endometrium(6)|large_intestine(1)|lung(10)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	26	Renal(3;0.0405)					CGTTCACCATCTGCAGGTTGA	0.607000													3	85					0	0	1	0	0
MYLIP	29116	broad.mit.edu	37	6	16145390	16145390	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA5P-01A-11D-A391-08	TCGA-ZF-AA5P-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0fec8a1-76ee-40a1-80c5-4cf8ab5540c6	9375b535-87d5-4b4e-81ab-8986e4e1dce3	g.chr6:16145390G>A	ENST00000349606.4	+	5	1051	c.547G>A	c.(547-549)Gag>Aag	p.E183K	MYLIP_ENST00000356840.3_Missense_Mutation_p.E364K			Q8WY64	MYLIP_HUMAN	myosin regulatory light chain interacting protein	364	FERM.				cellular component movement|nervous system development	cytoplasm|cytoskeleton|extrinsic to membrane	cytoskeletal protein binding|ubiquitin-protein ligase activity|zinc ion binding			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(3)|lung(13)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	28	Breast(50;0.0799)|Ovarian(93;0.103)	all_hematologic(90;0.0895)	Epithelial(50;0.241)			CAGCAGCTGCGAGGGCCTCAG	0.572000													6	92					0	0	1	0	0
PPARG	5468	broad.mit.edu	37	3	12447507	12447507	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA5P-01A-11D-A391-08	TCGA-ZF-AA5P-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0fec8a1-76ee-40a1-80c5-4cf8ab5540c6	9375b535-87d5-4b4e-81ab-8986e4e1dce3	g.chr3:12447507C>T	ENST00000397026.2	+	7	1063	c.680C>T	c.(679-681)tCa>tTa	p.S227L	PPARG_ENST00000397015.2_Missense_Mutation_p.S221L|PPARG_ENST00000397010.2_Missense_Mutation_p.S221L|PPARG_ENST00000539812.1_Missense_Mutation_p.S219L|PPARG_ENST00000287820.6_Missense_Mutation_p.S249L|PPARG_ENST00000309576.6_Missense_Mutation_p.S221L|PPARG_ENST00000397012.2_Missense_Mutation_p.S221L|PPARG_ENST00000397000.1_Missense_Mutation_p.S221L			P37231	PPARG_HUMAN	peroxisome proliferator-activated receptor gamma	249	Interaction with FAM120B (By similarity).				activation of caspase activity|cell fate commitment|cell maturation|cellular response to insulin stimulus|epithelial cell differentiation|glucose homeostasis|induction of apoptosis|innate immune response|lipid homeostasis|lipoprotein transport|long-chain fatty acid transport|low-density lipoprotein particle receptor biosynthetic process|monocyte differentiation|negative regulation of cholesterol storage|negative regulation of interferon-gamma-mediated signaling pathway|negative regulation of macrophage derived foam cell differentiation|negative regulation of receptor biosynthetic process|negative regulation of sequestering of triglyceride|negative regulation of transcription from RNA polymerase II promoter|placenta development|positive regulation of fat cell differentiation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of blood pressure|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to lipid|response to low-density lipoprotein particle stimulus|white fat cell differentiation	cytosol|nucleoplasm	activating transcription factor binding|arachidonic acid binding|drug binding|enzyme binding|prostaglandin receptor activity|retinoid X receptor binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|transcription regulatory region DNA binding|zinc ion binding		PAX8/PPARG(117)	breast(2)|endometrium(4)|kidney(3)|large_intestine(1)|lung(6)|ovary(1)|prostate(1)|skin(1)|stomach(1)	20					Atorvastatin(DB01076)|Icosapent(DB00159)|Pioglitazone(DB01132)|Rosiglitazone(DB00412)|Troglitazone(DB00197)	TTGTATGACTCATACATAAAG	0.502000			T	PAX8	follicular thyroid		"""Insulin resistance ; lipodystrophy, familial partial L;diabetes mellitus, insulin-resistantI, with acanthosis nigricans and hypertension"""						13	21					0	0	1	0	0
SEMG1	6406	broad.mit.edu	37	20	43837086	43837086	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA5P-01A-11D-A391-08	TCGA-ZF-AA5P-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0fec8a1-76ee-40a1-80c5-4cf8ab5540c6	9375b535-87d5-4b4e-81ab-8986e4e1dce3	g.chr20:43837086C>T	ENST00000372781.3	+	2	1205	c.1148C>T	c.(1147-1149)gCa>gTa	p.A383V	SEMG1_ENST00000244069.6_Missense_Mutation_p.A323V	NM_003007.3	NP_002998.1			semenogelin I											cervix(1)|endometrium(2)|kidney(3)|large_intestine(3)|liver(1)|lung(12)|prostate(1)|skin(6)|stomach(2)|urinary_tract(1)	32		Myeloproliferative disorder(115;0.0122)				AAGCTAGTAGCAGGCAAGTCT	0.433000													3	39					0	0	1	0	0
LZTR1	8216	broad.mit.edu	37	22	21341816	21341816	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA5P-01A-11D-A391-08	TCGA-ZF-AA5P-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0fec8a1-76ee-40a1-80c5-4cf8ab5540c6	9375b535-87d5-4b4e-81ab-8986e4e1dce3	g.chr22:21341816C>T	ENST00000215739.8	+	4	703	c.344C>T	c.(343-345)cCg>cTg	p.P115L	LZTR1_ENST00000389355.3_Missense_Mutation_p.P96L|LZTR1_ENST00000479606.1_3'UTR	NM_006767.3	NP_006758.2	Q8N653	LZTR1_HUMAN	leucine-zipper-like transcription regulator 1	115					anatomical structure morphogenesis		sequence-specific DNA binding transcription factor activity			breast(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(6)|lung(13)|ovary(3)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(3)	42	all_cancers(11;1.83e-25)|all_epithelial(7;9.19e-23)|Lung NSC(8;3.06e-15)|all_lung(8;5.05e-14)|Melanoma(16;0.000465)|Ovarian(15;0.0028)|Colorectal(54;0.0332)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.000204)|Lung(15;0.00494)|Epithelial(17;0.195)			GGGACCCCACCGGCCCCCCGT	0.667000													6	47					0	0	1	0	0
ZNF57	126295	broad.mit.edu	37	19	2917193	2917193	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA5P-01A-11D-A391-08	TCGA-ZF-AA5P-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0fec8a1-76ee-40a1-80c5-4cf8ab5540c6	9375b535-87d5-4b4e-81ab-8986e4e1dce3	g.chr19:2917193G>A	ENST00000306908.5	+	4	722	c.574G>A	c.(574-576)Gag>Aag	p.E192K	AC006277.2_ENST00000520090.2_RNA|ZNF57_ENST00000523428.1_Missense_Mutation_p.E160K	NM_173480.2	NP_775751.1	Q68EA5	ZNF57_HUMAN	zinc finger protein 57	192					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|kidney(2)|large_intestine(5)|lung(2)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	18				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|GBM - Glioblastoma multiforme(1328;0.00161)|STAD - Stomach adenocarcinoma(1328;0.18)		AACTGACACTGAGGAGAAGCC	0.498000													3	44					0	0	1	0	0
CD37	951	broad.mit.edu	37	19	49838988	49838988	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA5P-01A-11D-A391-08	TCGA-ZF-AA5P-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0fec8a1-76ee-40a1-80c5-4cf8ab5540c6	9375b535-87d5-4b4e-81ab-8986e4e1dce3	g.chr19:49838988C>G	ENST00000535669.2	+	2	201	c.87C>G	c.(85-87)atC>atG	p.I29M	CTC-301O7.4_ENST00000358234.4_lincRNA|CD37_ENST00000596426.1_3'UTR|CD37_ENST00000598095.1_5'UTR|CD37_ENST00000426897.2_5'UTR|CD37_ENST00000323906.4_Missense_Mutation_p.I29M			P11049	CD37_HUMAN	CD37 molecule	29						integral to membrane		p.I29I(2)		breast(1)|endometrium(1)|large_intestine(3)|lung(5)|upper_aerodigestive_tract(1)	11		all_lung(116;2.81e-06)|Lung NSC(112;5.89e-06)|all_neural(266;0.0189)|Ovarian(192;0.0392)		OV - Ovarian serous cystadenocarcinoma(262;0.00088)|GBM - Glioblastoma multiforme(486;0.0443)		GCAGCCTGATCTTCTGCTTCG	0.662000													10	276					0	0	1	0	0
FBXW12	285231	broad.mit.edu	37	3	48423525	48423525	+	Silent	SNP	C	C	A			TCGA-ZF-AA5P-01A-11D-A391-08	TCGA-ZF-AA5P-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0fec8a1-76ee-40a1-80c5-4cf8ab5540c6	9375b535-87d5-4b4e-81ab-8986e4e1dce3	g.chr3:48423525C>A	ENST00000296438.5	+	10	1431	c.1245C>A	c.(1243-1245)ctC>ctA	p.L415L	FBXW12_ENST00000415155.1_Silent_p.L345L|FBXW12_ENST00000436231.1_Silent_p.L258L|FBXW12_ENST00000468158.1_3'UTR|FBXW12_ENST00000445170.1_Silent_p.L396L	NM_207102.2	NP_996985.2	Q6X9E4	FBW12_HUMAN	F-box and WD repeat domain containing 12	415										breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(5)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	16				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		ATCCATACCTCAGGAGCTGCT	0.473000													9	53					0.00448238	0.00494081	1	1	0
KCNJ4	3761	broad.mit.edu	37	22	38823348	38823348	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA5P-01A-11D-A391-08	TCGA-ZF-AA5P-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0fec8a1-76ee-40a1-80c5-4cf8ab5540c6	9375b535-87d5-4b4e-81ab-8986e4e1dce3	g.chr22:38823348C>T	ENST00000303592.3	-	2	1048	c.790G>A	c.(790-792)Gag>Aag	p.E264K		NM_004981.1|NM_152868.2	NP_004972.1|NP_690607.1	P48050	IRK4_HUMAN	potassium inwardly-rectifying channel, subfamily J, member 4	264					synaptic transmission	basolateral plasma membrane|voltage-gated potassium channel complex	inward rectifier potassium channel activity|PDZ domain binding			endometrium(7)|kidney(1)|large_intestine(2)|lung(8)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	23	Melanoma(58;0.0286)					TCGTCGATCTCGTGGACAATG	0.617000													5	33					0	0	1	0	0
CCDC25	55246	broad.mit.edu	37	8	27606026	27606026	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA5P-01A-11D-A391-08	TCGA-ZF-AA5P-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0fec8a1-76ee-40a1-80c5-4cf8ab5540c6	9375b535-87d5-4b4e-81ab-8986e4e1dce3	g.chr8:27606026G>A	ENST00000356537.4	-	6	427	c.334C>T	c.(334-336)Cac>Tac	p.H112Y	CCDC25_ENST00000522915.1_Missense_Mutation_p.H44Y|CCDC25_ENST00000539095.1_Missense_Mutation_p.H44Y|RP11-16P20.3_ENST00000521510.1_RNA	NM_018246.2	NP_060716.2	Q86WR0	CCD25_HUMAN	coiled-coil domain containing 25	112										endometrium(1)|kidney(1)|large_intestine(1)|lung(3)|prostate(1)	7		Ovarian(32;0.000953)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0223)|KIRC - Kidney renal clear cell carcinoma(542;0.11)|Kidney(114;0.131)|Colorectal(74;0.154)		TTCTGCCTGTGAAAGCCTATC	0.468000													6	91					0	0	1	0	0
PFAS	5198	broad.mit.edu	37	17	8168889	8168889	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA5P-01A-11D-A391-08	TCGA-ZF-AA5P-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0fec8a1-76ee-40a1-80c5-4cf8ab5540c6	9375b535-87d5-4b4e-81ab-8986e4e1dce3	g.chr17:8168889C>T	ENST00000314666.6	+	20	2610	c.2477C>T	c.(2476-2478)tCa>tTa	p.S826L	PFAS_ENST00000545834.1_Missense_Mutation_p.S402L	NM_012393.2	NP_036525.1	O15067	PUR4_HUMAN	phosphoribosylformylglycinamidine synthase	826					'de novo' IMP biosynthetic process|glutamine metabolic process|purine base metabolic process	cytosol	ATP binding|phosphoribosylformylglycinamidine synthase activity|protein binding			central_nervous_system(3)|endometrium(8)|kidney(2)|large_intestine(2)|lung(9)|ovary(3)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)	35					L-Glutamic Acid(DB00142)|L-Glutamine(DB00130)	CTGGTCATCTCAGCCTATGCC	0.567000													12	66					0	0	1	0	0
ADAMTS7	11173	broad.mit.edu	37	15	79051886	79051886	+	Silent	SNP	G	G	A			TCGA-ZF-AA5P-01A-11D-A391-08	TCGA-ZF-AA5P-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0fec8a1-76ee-40a1-80c5-4cf8ab5540c6	9375b535-87d5-4b4e-81ab-8986e4e1dce3	g.chr15:79051886G>A	ENST00000388820.4	-	24	5148	c.4938C>T	c.(4936-4938)tgC>tgT	p.C1646C		NM_014272.3	NP_055087.2	Q9UKP4	ATS7_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 7	1646	PLAC.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding	p.C1646C(4)		NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(2)|lung(23)|ovary(1)|prostate(8)|skin(9)	54						GCAGCGTCTCGCAGAACCCGA	0.701000													3	4					0	0	1	0	0
TSG101	7251	broad.mit.edu	37	11	18502153	18502153	+	Silent	SNP	G	G	A			TCGA-ZF-AA5P-01A-11D-A391-08	TCGA-ZF-AA5P-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0fec8a1-76ee-40a1-80c5-4cf8ab5540c6	9375b535-87d5-4b4e-81ab-8986e4e1dce3	g.chr11:18502153G>A	ENST00000251968.3	-	10	1528	c.1113C>T	c.(1111-1113)ttC>ttT	p.F371F	TSG101_ENST00000536719.1_Intron|TSG101_ENST00000357193.3_Silent_p.F266F	NM_006292.3	NP_006283.1	Q99816	TS101_HUMAN	tumor susceptibility 101	371	SB.				cell division|cellular membrane organization|endosome transport|interspecies interaction between organisms|non-lytic virus budding|protein transport|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	early endosome|late endosome membrane|multivesicular body|nucleolus|plasma membrane	calcium-dependent protein binding|DNA binding|transcription corepressor activity|ubiquitin binding|ubiquitin protein ligase binding			kidney(1)|large_intestine(4)|lung(9)|ovary(1)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	22						CCCTCAGCTGGAACTGTTTAC	0.443000													4	37					0	0	1	0	0
KIAA1377	57562	broad.mit.edu	37	11	101832732	101832732	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA5P-01A-11D-A391-08	TCGA-ZF-AA5P-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0fec8a1-76ee-40a1-80c5-4cf8ab5540c6	9375b535-87d5-4b4e-81ab-8986e4e1dce3	g.chr11:101832732G>C	ENST00000263468.8	+	6	1236	c.966G>C	c.(964-966)caG>caC	p.Q322H	KIAA1377_ENST00000537689.1_Missense_Mutation_p.Q123H	NM_020802.2	NP_065853.2	Q9P2H0	K1377_HUMAN	KIAA1377	322							protein binding			breast(4)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(12)|lung(18)|ovary(1)|prostate(4)|skin(3)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	53	all_epithelial(12;0.0104)	Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.00931)		BRCA - Breast invasive adenocarcinoma(274;0.038)		CAAATACTCAGAATGTCACAG	0.303000													3	70					0	0	1	0	0
FOLH1B	219595	broad.mit.edu	37	11	89395322	89395322	+	RNA	SNP	C	C	T			TCGA-ZF-AA5P-01A-11D-A391-08	TCGA-ZF-AA5P-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0fec8a1-76ee-40a1-80c5-4cf8ab5540c6	9375b535-87d5-4b4e-81ab-8986e4e1dce3	g.chr11:89395322C>T	ENST00000532352.1	+	0	720							Q9HBA9	FOH1B_HUMAN	folate hydrolase 1B						proteolysis	cytoplasm	dipeptidase activity|metal ion binding|metallopeptidase activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(7)|lung(26)|ovary(4)|skin(4)|urinary_tract(2)	48						TTTCAGAATACGCTTATAGGC	0.343000													4	43					0	0	1	0	0
IGHG1	3500	broad.mit.edu	37	14	106208487	106208487	+	RNA	SNP	C	C	T			TCGA-ZF-AA5P-01A-11D-A391-08	TCGA-ZF-AA5P-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0fec8a1-76ee-40a1-80c5-4cf8ab5540c6	9375b535-87d5-4b4e-81ab-8986e4e1dce3	g.chr14:106208487C>T	ENST00000390548.2	-	0	412																											CTCAGGGGTCCGGGAGATCAT	0.592000													19	108					0	0	1	0	0
SMCHD1	23347	broad.mit.edu	37	18	2770087	2770087	+	Silent	SNP	G	G	A			TCGA-ZF-AA5P-01A-11D-A391-08	TCGA-ZF-AA5P-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0fec8a1-76ee-40a1-80c5-4cf8ab5540c6	9375b535-87d5-4b4e-81ab-8986e4e1dce3	g.chr18:2770087G>A	ENST00000320876.6	+	39	5285	c.4947G>A	c.(4945-4947)caG>caA	p.Q1649Q	RP11-703M24.5_ENST00000583546.1_RNA|SMCHD1_ENST00000261598.8_Silent_p.Q1649Q	NM_015295.2	NP_056110.2	A6NHR9	SMHD1_HUMAN	structural maintenance of chromosomes flexible hinge domain containing 1	1649					chromosome organization		ATP binding			NS(3)|breast(3)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(16)|lung(15)|pancreas(1)	45						CCAGCCAACAGCTTCTTAATG	0.343000													4	45					0	0	1	0	0
SLC1A5	6510	broad.mit.edu	37	19	47280590	47280590	+	Silent	SNP	G	G	A			TCGA-ZF-AA5P-01A-11D-A391-08	TCGA-ZF-AA5P-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0fec8a1-76ee-40a1-80c5-4cf8ab5540c6	9375b535-87d5-4b4e-81ab-8986e4e1dce3	g.chr19:47280590G>A	ENST00000542575.2	-	6	1759	c.1131C>T	c.(1129-1131)ttC>ttT	p.F377F	SLC1A5_ENST00000412532.2_Silent_p.F149F|SLC1A5_ENST00000434726.2_Silent_p.F175F|SLC1A5_ENST00000594991.1_Silent_p.F201F	NM_005628.2	NP_005619.1	Q15758	AAAT_HUMAN	solute carrier family 1 (neutral amino acid transporter), member 5	377					cellular nitrogen compound metabolic process	integral to plasma membrane|melanosome|membrane fraction	neutral amino acid transmembrane transporter activity|protein binding|receptor activity|sodium:dicarboxylate symporter activity			cervix(1)|endometrium(3)|kidney(3)|large_intestine(3)|lung(2)|stomach(1)	13		all_epithelial(76;0.00314)|Ovarian(192;0.0798)|all_neural(266;0.107)		OV - Ovarian serous cystadenocarcinoma(262;0.000338)|all cancers(93;0.000882)|Epithelial(262;0.0211)|GBM - Glioblastoma multiforme(486;0.0341)	L-Asparagine(DB00174)|L-Glutamine(DB00130)	TGGGCAGGATGAAACGGCTGA	0.607000													3	28					0	0	1	0	0
IGHV3-16	28447	broad.mit.edu	37	14	106622327	106622327	+	RNA	SNP	A	A	T			TCGA-ZF-AA5P-01A-11D-A391-08	TCGA-ZF-AA5P-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0fec8a1-76ee-40a1-80c5-4cf8ab5540c6	9375b535-87d5-4b4e-81ab-8986e4e1dce3	g.chr14:106622327A>T	ENST00000390604.2	-	0	92																											AGAAAAACCCAGCTCAGCCCA	0.458000													8	57					0	0	1	0	0
SAGE1	55511	broad.mit.edu	37	X	134983819	134983819	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA5P-01A-11D-A391-08	TCGA-ZF-AA5P-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0fec8a1-76ee-40a1-80c5-4cf8ab5540c6	9375b535-87d5-4b4e-81ab-8986e4e1dce3	g.chrX:134983819G>C	ENST00000535938.1	+	3	356	c.189G>C	c.(187-189)aaG>aaC	p.K63N	SAGE1_ENST00000537770.1_Missense_Mutation_p.K63N|SAGE1_ENST00000324447.3_Missense_Mutation_p.K63N|SAGE1_ENST00000370709.3_Missense_Mutation_p.K63N	NM_018666.2	NP_061136.2	Q9NXZ1	SAGE1_HUMAN	sarcoma antigen 1	63										breast(5)|endometrium(5)|large_intestine(10)|lung(23)|ovary(3)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	55	Acute lymphoblastic leukemia(192;0.000127)					AGAGAAGGAAGAGTATGTCCT	0.428000													6	98					0	0	1	0	0
KRTAP4-11	653240	broad.mit.edu	37	17	39274291	39274291	+	Missense_Mutation	SNP	T	T	C	rs149439944	by1000genomes	TCGA-ZF-AA5P-01A-11D-A391-08	TCGA-ZF-AA5P-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0fec8a1-76ee-40a1-80c5-4cf8ab5540c6	9375b535-87d5-4b4e-81ab-8986e4e1dce3	g.chr17:39274291T>C	ENST00000391413.2	-	1	315	c.277A>G	c.(277-279)Atg>Gtg	p.M93V		NM_033059.3	NP_149048.2	Q9BYQ6	KR411_HUMAN	keratin associated protein 4-11	93	27 X 5 AA repeats of C-C-[GIKRQVHEL]- [SPTR]-[STVQRMC].					keratin filament		p.M93V(4)		endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|lung(8)|prostate(5)|skin(1)	33		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000371)			TGGCAGCACATAGACTGGCAG	0.662000													3	25					0	0	1	0	0
NFATC2	4773	broad.mit.edu	37	20	50051780	50051780	+	Silent	SNP	G	G	A	rs142900177		TCGA-ZF-AA5P-01A-11D-A391-08	TCGA-ZF-AA5P-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0fec8a1-76ee-40a1-80c5-4cf8ab5540c6	9375b535-87d5-4b4e-81ab-8986e4e1dce3	g.chr20:50051780G>A	ENST00000371564.3	-	8	2196	c.1977C>T	c.(1975-1977)taC>taT	p.Y659Y	NFATC2_ENST00000414705.1_Silent_p.Y639Y|NFATC2_ENST00000396009.3_Silent_p.Y659Y|NFATC2_ENST00000610033.1_Silent_p.Y440Y|NFATC2_ENST00000609507.1_Silent_p.Y440Y|NFATC2_ENST00000609943.1_Silent_p.Y639Y	NM_001258296.1|NM_012340.4	NP_001245225.1|NP_036472.2	Q13469	NFAC2_HUMAN	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2	659					B cell receptor signaling pathway|positive regulation of B cell proliferation|response to DNA damage stimulus|response to drug	actin cytoskeleton|nucleus|plasma membrane	protein binding|sequence-specific DNA binding transcription factor activity		EWSR1/NFATC2(9)	breast(2)|endometrium(7)|kidney(1)|large_intestine(7)|lung(25)|ovary(2)|prostate(2)|skin(5)|stomach(1)|urinary_tract(1)	53	Hepatocellular(150;0.248)					CATTGATGACGTAGAAGTTCA	0.428000													20	171					0	0	1	0	0
PRKD1	5587	broad.mit.edu	37	14	30068919	30068919	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA5P-01A-11D-A391-08	TCGA-ZF-AA5P-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0fec8a1-76ee-40a1-80c5-4cf8ab5540c6	9375b535-87d5-4b4e-81ab-8986e4e1dce3	g.chr14:30068919G>C	ENST00000331968.5	-	14	2239	c.2010C>G	c.(2008-2010)atC>atG	p.I670M	PRKD1_ENST00000415220.2_Missense_Mutation_p.I678M	NM_002742.2	NP_002733.2	Q15139	KPCD1_HUMAN	protein kinase D1	670	Protein kinase.				cell proliferation|intracellular signal transduction|sphingolipid metabolic process	cytosol|integral to plasma membrane	ATP binding|metal ion binding|protein binding|protein kinase C activity			NS(1)|breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(21)|lung(32)|ovary(2)|prostate(1)|skin(4)|urinary_tract(2)	78	Hepatocellular(127;0.0604)		LUAD - Lung adenocarcinoma(48;0.00527)|Lung(238;0.0252)	GBM - Glioblastoma multiforme(265;0.00888)		CACTTGACAAGATCATTTCCA	0.363000													7	85					0	0	1	0	0
ARL6	84100	broad.mit.edu	37	3	97516867	97516867	+	Splice_Site	SNP	G	G	C			TCGA-ZF-AA5P-01A-11D-A391-08	TCGA-ZF-AA5P-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0fec8a1-76ee-40a1-80c5-4cf8ab5540c6	9375b535-87d5-4b4e-81ab-8986e4e1dce3	g.chr3:97516867G>C	ENST00000463745.1	+	8	1012		c.e8-1		ARL6_ENST00000335979.2_Splice_Site|ARL6_ENST00000394206.1_Splice_Site	NM_001278293.1	NP_001265222.1	Q9H0F7	ARL6_HUMAN	ADP-ribosylation factor-like 6						cilium assembly|determination of left/right symmetry|melanosome transport|protein polymerization|protein targeting to membrane|small GTPase mediated signal transduction|visual perception|Wnt receptor signaling pathway	axonemal microtubule|cilium axoneme|cilium membrane|membrane coat|microtubule basal body	GTP binding|metal ion binding|phospholipid binding|protein binding			large_intestine(1)|lung(4)	5		Lung NSC(201;0.0193)|Prostate(884;0.174)		LUSC - Lung squamous cell carcinoma(29;0.0118)|Lung(72;0.0189)		TTTGTTATCAGATCAGATCCA	0.284000													6	149					0	0	1	0	0
COG4	25839	broad.mit.edu	37	16	70530258	70530258	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-AA5P-01A-11D-A391-08	TCGA-ZF-AA5P-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0fec8a1-76ee-40a1-80c5-4cf8ab5540c6	9375b535-87d5-4b4e-81ab-8986e4e1dce3	g.chr16:70530258C>A	ENST00000323786.5	-	12	1579	c.1558G>T	c.(1558-1560)Gcc>Tcc	p.A520S		NM_001195139.1|NM_015386.2	NP_001182068.1|NP_056201.2	Q9H9E3	COG4_HUMAN	component of oligomeric golgi complex 4	516					Golgi organization|Golgi vesicle prefusion complex stabilization|protein transport|retrograde vesicle-mediated transport, Golgi to ER	Golgi membrane|Golgi transport complex	protein binding			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(8)|lung(12)|pancreas(1)|prostate(2)	33		Ovarian(137;0.0694)				ATGTTCACGGCACTTGTCACC	0.557000													3	44					0.150653	0.153825	1	1	0
PDS5B	23047	broad.mit.edu	37	13	33232664	33232664	+	Missense_Mutation	SNP	A	A	T			TCGA-ZF-AA5P-01A-11D-A391-08	TCGA-ZF-AA5P-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0fec8a1-76ee-40a1-80c5-4cf8ab5540c6	9375b535-87d5-4b4e-81ab-8986e4e1dce3	g.chr13:33232664A>T	ENST00000315596.10	+	5	679	c.493A>T	c.(493-495)Ata>Tta	p.I165L		NM_015032.3	NP_055847.1	Q9NTI5	PDS5B_HUMAN	PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae)	165					cell division|cell proliferation|mitotic sister chromatid cohesion|negative regulation of cell proliferation	chromatin|nucleus	ATP binding|DNA binding|identical protein binding			NS(2)|breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(14)|lung(14)|ovary(5)|pancreas(1)|prostate(5)|skin(1)|upper_aerodigestive_tract(1)	62		Lung SC(185;0.0367)		all cancers(112;5.55e-06)|Epithelial(112;2.7e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00303)|BRCA - Breast invasive adenocarcinoma(63;0.0204)		ATTTTCAGTTATAAAGTAAGT	0.269000													5	65					0	0	1	0	0
CLIP1	6249	broad.mit.edu	37	12	122862043	122862043	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA5P-01A-11D-A391-08	TCGA-ZF-AA5P-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0fec8a1-76ee-40a1-80c5-4cf8ab5540c6	9375b535-87d5-4b4e-81ab-8986e4e1dce3	g.chr12:122862043G>C	ENST00000358808.2	-	3	704	c.550C>G	c.(550-552)Ccg>Gcg	p.P184A	CLIP1_ENST00000361654.4_Missense_Mutation_p.P184A|CLIP1_ENST00000537178.1_Missense_Mutation_p.P184A|CLIP1_ENST00000540338.1_Missense_Mutation_p.P184A|CLIP1_ENST00000302528.7_Missense_Mutation_p.P184A	NM_001247997.1|NM_002956.2	NP_001234926.1|NP_002947.1	P30622	CLIP1_HUMAN	CAP-GLY domain containing linker protein 1	184	Ser-rich.				mitotic prometaphase|positive regulation of microtubule polymerization	centrosome|cytosol|endosome|intermediate filament|kinetochore	nucleic acid binding|protein homodimerization activity|zinc ion binding			NS(1)|breast(5)|endometrium(4)|kidney(5)|large_intestine(16)|liver(1)|lung(21)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	60	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.81e-05)|Epithelial(86;6.85e-05)|BRCA - Breast invasive adenocarcinoma(302;0.226)		TTGCTGATCGGAGGCGTAGCT	0.507000													8	169					0	0	1	0	0
THAP3	90326	broad.mit.edu	37	1	6688688	6688688	+	Silent	SNP	A	A	C			TCGA-ZF-AA5P-01A-11D-A391-08	TCGA-ZF-AA5P-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0fec8a1-76ee-40a1-80c5-4cf8ab5540c6	9375b535-87d5-4b4e-81ab-8986e4e1dce3	g.chr1:6688688A>C	ENST00000377627.3	+	2	231	c.204A>C	c.(202-204)ggA>ggC	p.G68G	THAP3_ENST00000307896.6_Silent_p.G68G|THAP3_ENST00000054650.4_Silent_p.G68G	NM_138350.3	NP_612359.2	Q8WTV1	THAP3_HUMAN	THAP domain containing, apoptosis associated protein 3	68							DNA binding|metal ion binding			breast(1)|cervix(1)|large_intestine(1)|prostate(1)	4	Ovarian(185;0.0212)|all_lung(157;0.154)	all_cancers(23;7.39e-28)|all_epithelial(116;1.76e-17)|all_lung(118;2.27e-05)|Lung NSC(185;9.97e-05)|Renal(390;0.00188)|Breast(487;0.00289)|Colorectal(325;0.00342)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.156)		Colorectal(212;1.29e-07)|COAD - Colon adenocarcinoma(227;1.33e-05)|Kidney(185;4.89e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000513)|KIRC - Kidney renal clear cell carcinoma(229;0.000896)|STAD - Stomach adenocarcinoma(132;0.0167)|READ - Rectum adenocarcinoma(331;0.0642)		GCGCCTTTGGAAACCGCAAGA	0.592000													4	47					0	0	1	0	0
NPHP3	27031	broad.mit.edu	37	3	132413764	132413764	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-AA5P-01A-11D-A391-08	TCGA-ZF-AA5P-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0fec8a1-76ee-40a1-80c5-4cf8ab5540c6	9375b535-87d5-4b4e-81ab-8986e4e1dce3	g.chr3:132413764G>T	ENST00000337331.5	-	16	2303	c.2217C>A	c.(2215-2217)ttC>ttA	p.F739L	NPHP3_ENST00000326682.8_3'UTR	NM_153240.4	NP_694972.3	Q7Z494	NPHP3_HUMAN	nephronophthisis 3 (adolescent)	739					maintenance of organ identity|negative regulation of canonical Wnt receptor signaling pathway|photoreceptor cell maintenance|regulation of Wnt receptor signaling pathway, planar cell polarity pathway|Wnt receptor signaling pathway	cilium	protein binding			NS(1)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(5)|lung(15)|ovary(2)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	42						CTTGACACTGGAAACACTGAT	0.388000													4	98					5.9392e-07	7.11238e-07	1	1	0
ZNF594	84622	broad.mit.edu	37	17	5086456	5086456	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA5P-01A-11D-A391-08	TCGA-ZF-AA5P-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0fec8a1-76ee-40a1-80c5-4cf8ab5540c6	9375b535-87d5-4b4e-81ab-8986e4e1dce3	g.chr17:5086456C>T	ENST00000399604.4	-	1	1236	c.1096G>A	c.(1096-1098)Gag>Aag	p.E366K	ZNF594_ENST00000575779.1_Missense_Mutation_p.E366K			Q96JF6	ZN594_HUMAN	zinc finger protein 594	366					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(3)|lung(10)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	33						ATTCTCTGCTCTTCCCTAAGC	0.448000													8	243					0	0	1	0	0
LRRC37A4P	55073	broad.mit.edu	37	17	43587576	43587576	+	RNA	SNP	A	A	G	rs145439557	by1000genomes	TCGA-ZF-AA5P-01A-11D-A391-08	TCGA-ZF-AA5P-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0fec8a1-76ee-40a1-80c5-4cf8ab5540c6	9375b535-87d5-4b4e-81ab-8986e4e1dce3	g.chr17:43587576A>G	ENST00000253803.2	+	0	267				LRRC37A4P_ENST00000579913.1_RNA																							tctgaaaagaaaagaaaaaaa	0.428000													6	47					0	0	1	0	0
LRRC37A4P	55073	broad.mit.edu	37	17	43587569	43587569	+	RNA	SNP	G	G	C	rs149697015	by1000genomes	TCGA-ZF-AA5P-01A-11D-A391-08	TCGA-ZF-AA5P-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0fec8a1-76ee-40a1-80c5-4cf8ab5540c6	9375b535-87d5-4b4e-81ab-8986e4e1dce3	g.chr17:43587569G>C	ENST00000253803.2	+	0	267				LRRC37A4P_ENST00000579913.1_RNA																							aactccgtctgaaaagaaaag	0.443000													4	32					0	0	1	0	0
ABCC5	10057	broad.mit.edu	37	3	183679424	183679424	+	Nonsense_Mutation	SNP	C	C	A			TCGA-ZF-AA5P-01A-11D-A391-08	TCGA-ZF-AA5P-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0fec8a1-76ee-40a1-80c5-4cf8ab5540c6	9375b535-87d5-4b4e-81ab-8986e4e1dce3	g.chr3:183679424C>A	ENST00000334444.6	-	16	2494	c.2254G>T	c.(2254-2256)Gaa>Taa	p.E752*	ABCC5_ENST00000265586.6_Nonsense_Mutation_p.E752*	NM_005688.2	NP_005679.2	O15440	MRP5_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 5	752	ABC transporter 1.					integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of substances|organic anion transmembrane transporter activity			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(9)|lung(32)|ovary(3)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	62	all_cancers(143;1.85e-10)|Ovarian(172;0.0303)		Epithelial(37;1.74e-35)|OV - Ovarian serous cystadenocarcinoma(80;6.48e-22)			AAGATCACTTCATCACAGTCA	0.388000													4	71					0.014758	0.0155601	1	1	0
UBE2Q1	55585	broad.mit.edu	37	1	154525581	154525581	+	Frame_Shift_Del	DEL	T	T	-			TCGA-ZF-AA5P-01A-11D-A391-08	TCGA-ZF-AA5P-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0fec8a1-76ee-40a1-80c5-4cf8ab5540c6	9375b535-87d5-4b4e-81ab-8986e4e1dce3	g.chr1:154525581delT	ENST00000292211.4	-	5	735	c.656delA	c.(655-657)gatfs	p.D220fs	UBE2Q1_ENST00000497453.1_5'UTR	NM_017582.6	NP_060052.3	Q7Z7E8	UB2Q1_HUMAN	ubiquitin-conjugating enzyme E2Q family member 1	220							ATP binding|protein binding|ubiquitin-protein ligase activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(3)|lung(6)|upper_aerodigestive_tract(1)	16	all_lung(78;1.72e-29)|Lung NSC(65;2.96e-27)|Hepatocellular(266;0.0877)|all_hematologic(923;0.088)		LUSC - Lung squamous cell carcinoma(543;0.185)			AATGCCATCATCTTCAGATTT	0.433													9	81	---	---	---	---					
HSPD1P6	645548	broad.mit.edu	37	3	36810381	36810381	+	RNA	DEL	T	T	-			TCGA-ZF-AA5P-01A-11D-A391-08	TCGA-ZF-AA5P-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0fec8a1-76ee-40a1-80c5-4cf8ab5540c6	9375b535-87d5-4b4e-81ab-8986e4e1dce3	g.chr3:36810381delT	ENST00000424886.1	-	0	405																											GAGTGAGGCCttttttttttt	0.542													2	4	---	---	---	---					
PMS2CL	441194	broad.mit.edu	37	7	6775144	6775144	+	RNA	DEL	C	C	-	rs28729319		TCGA-ZF-AA5P-01A-11D-A391-08	TCGA-ZF-AA5P-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0fec8a1-76ee-40a1-80c5-4cf8ab5540c6	9375b535-87d5-4b4e-81ab-8986e4e1dce3	g.chr7:6775144delC	ENST00000486256.1	+	0	833					NR_002217.1																						TTTTTTTTTTCTTTTTGAGAC	0.398													2	4	---	---	---	---					
AGAP11	119385	broad.mit.edu	37	10	88767686	88767686	+	RNA	DEL	T	T	-	rs71019446		TCGA-ZF-AA5P-01A-11D-A391-08	TCGA-ZF-AA5P-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0fec8a1-76ee-40a1-80c5-4cf8ab5540c6	9375b535-87d5-4b4e-81ab-8986e4e1dce3	g.chr10:88767686delT	ENST00000444431.1	+	0	2711				RP11-96C23.5_ENST00000433214.2_RNA|RP11-96C23.14_ENST00000444180.3_RNA			Q8TF27	AGA11_HUMAN	ankyrin repeat and GTPase domain Arf GTPase activating protein 11						regulation of ARF GTPase activity		ARF GTPase activator activity|zinc ion binding										AAAATGTATCttttttttttt	0.413													2	4	---	---	---	---					
HERC2P9	440248	broad.mit.edu	37	15	28900331	28900331	+	RNA	DEL	A	A	-			TCGA-ZF-AA5P-01A-11D-A391-08	TCGA-ZF-AA5P-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0fec8a1-76ee-40a1-80c5-4cf8ab5540c6	9375b535-87d5-4b4e-81ab-8986e4e1dce3	g.chr15:28900331delA	ENST00000528584.1	+	0	14					NR_036443.1																						actctgtctcaaaaaaaaaaa	0.413													3	3	---	---	---	---					
IL9RP3	729486	broad.mit.edu	37	16	81973	81974	+	RNA	INS	-	-	GTCC			TCGA-ZF-AA5P-01A-11D-A391-08	TCGA-ZF-AA5P-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0fec8a1-76ee-40a1-80c5-4cf8ab5540c6	9375b535-87d5-4b4e-81ab-8986e4e1dce3	g.chr16:81973_81974insGTCC	ENST00000568710.1	-	0	349																											ATCAGCAGGAGGCCCACCTCGT	0.614													2	4	---	---	---	---					
NPIPB11	728888	broad.mit.edu	37	16	29394767	29394769	+	In_Frame_Del	DEL	TAT	TAT	-			TCGA-ZF-AA5P-01A-11D-A391-08	TCGA-ZF-AA5P-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0fec8a1-76ee-40a1-80c5-4cf8ab5540c6	9375b535-87d5-4b4e-81ab-8986e4e1dce3	g.chr16:29394767_29394769delTAT	ENST00000524087.1	-	8	1558_1560	c.1484_1486delATA	c.(1483-1488)aatatc>atc	p.N495del	SNX29P2_ENST00000398878.3_lincRNA					nuclear pore complex interacting protein family, member B11																		GGTGTCTTGATATTATCATCTGC	0.586													3	3	---	---	---	---					
UPF1	5976	broad.mit.edu	37	19	18976891	18976891	+	Frame_Shift_Del	DEL	C	C	-			TCGA-ZF-AA5P-01A-11D-A391-08	TCGA-ZF-AA5P-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0fec8a1-76ee-40a1-80c5-4cf8ab5540c6	9375b535-87d5-4b4e-81ab-8986e4e1dce3	g.chr19:18976891delC	ENST00000262803.5	+	23	3548	c.3276delC	c.(3274-3276)gacfs	p.D1092fs	UPF1_ENST00000599848.1_Frame_Shift_Del_p.D1103fs	NM_002911.3	NP_002902.2	Q92900	RENT1_HUMAN	UPF1 regulator of nonsense transcripts homolog (yeast)	1103	Gln/Ser-rich.				cell cycle|DNA repair|DNA replication|histone mRNA catabolic process|mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of translational termination	chromatin|cytoplasmic mRNA processing body|exon-exon junction complex	ATP binding|ATP-dependent RNA helicase activity|chromatin binding|DNA binding|protein binding|RNA binding|zinc ion binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(11)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	40						CACAAATCGACGTGGCGCTCT	0.577													8	94	---	---	---	---					
CD3EAP	10849	broad.mit.edu	37	19	45911859	45911861	+	In_Frame_Del	DEL	GAA	GAA	-			TCGA-ZF-AA5P-01A-11D-A391-08	TCGA-ZF-AA5P-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0fec8a1-76ee-40a1-80c5-4cf8ab5540c6	9375b535-87d5-4b4e-81ab-8986e4e1dce3	g.chr19:45911859_45911861delGAA	ENST00000309424.3	+	3	1121_1123	c.633_635delGAA	c.(631-636)cggaag>cgg	p.K217del	ERCC1_ENST00000300853.3_3'UTR|ERCC1_ENST00000423698.2_3'UTR|CD3EAP_ENST00000589804.1_In_Frame_Del_p.K219del	NM_012099.1	NP_036231.1	O15446	RPA34_HUMAN	CD3e molecule, epsilon associated protein	217	Poly-Lys.				rRNA transcription|transmembrane receptor protein tyrosine kinase signaling pathway	chromosome|RNA polymerase I transcription factor complex	DNA-directed RNA polymerase activity			breast(2)|endometrium(1)|large_intestine(3)|lung(2)|ovary(2)|prostate(1)	11		all_neural(266;0.224)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.0251)		TGGATGTGCGGAAGAAGAAGAAG	0.581													7	96	---	---	---	---					
RNA5-8SP6	100873336	broad.mit.edu	37	Y	10037863	10037863	+	RNA	DEL	C	C	-			TCGA-ZF-AA5P-01A-11D-A391-08	TCGA-ZF-AA5P-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0fec8a1-76ee-40a1-80c5-4cf8ab5540c6	9375b535-87d5-4b4e-81ab-8986e4e1dce3	g.chrY:10037863delC	ENST00000515896.1	+	0	100																											ATCGACACTTCGAACGCACTT	0.552													3	6	---	---	---	---