Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values
WDR65	149465	broad.mit.edu	37	1	43651007	43651007	+	Missense_Mutation	SNP	C	C	A			TCGA-06-0139-01A-01D-1490-08	TCGA-06-0139-10A-01D-1490-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c84ff17d-436d-49c1-aef2-b998ffe4a693	c739fdc7-b0df-4096-a7dd-50f519c9160f	g.chr1:43651007C>A	uc021omk.1	+	4	1095	c.949C>A	c.(949-951)Cgt>Agt	p.R317S	EBNA1BP2_uc001cio.3_Intron|WDR65_uc010ojz.2_Missense_Mutation_p.R306S|WDR65_uc001ciq.2_Missense_Mutation_p.R317S|WDR65_uc001cip.2_Missense_Mutation_p.R317S	NM_001195831	NP_001182760	Q96MR6	WDR65_HUMAN	Homo sapiens WD repeat domain 65 (WDR65), transcript variant 5, mRNA.	317										NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(7)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	23	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				GGATTTTTACCGTGAGAGCAG	0.473												
OR4F6	390648	broad.mit.edu	37	15	102346736	102346736	+	Missense_Mutation	SNP	G	G	A			TCGA-06-0139-01A-01D-1490-08	TCGA-06-0139-10A-01D-1490-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c84ff17d-436d-49c1-aef2-b998ffe4a693	c739fdc7-b0df-4096-a7dd-50f519c9160f	g.chr15:102346736G>A	uc010utr.2	+	0	814	c.814G>A	c.(814-816)Gcc>Acc	p.A272T		NM_001005326	NP_001005326	Q8NGB9	OR4F6_HUMAN	Homo sapiens olfactory receptor, family 4, subfamily F, member 6 (OR4F6), mRNA.	272					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|large_intestine(1)|lung(16)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	22	Lung NSC(78;0.000991)|all_lung(78;0.00128)|Melanoma(26;0.00505)		OV - Ovarian serous cystadenocarcinoma(32;0.00039)|Lung(145;0.17)|LUSC - Lung squamous cell carcinoma(107;0.187)			TAAATTCCTTGCCATCTTTGA	0.378												
TANC2	26115	broad.mit.edu	37	17	61391934	61391934	+	Missense_Mutation	SNP	G	G	A			TCGA-06-0139-01A-01D-1490-08	TCGA-06-0139-10A-01D-1490-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c84ff17d-436d-49c1-aef2-b998ffe4a693	c739fdc7-b0df-4096-a7dd-50f519c9160f	g.chr17:61391934G>A	uc002jal.4	+	7	1146	c.1123G>A	c.(1123-1125)Ggc>Agc	p.G375S	TANC2_uc010wpe.2_Missense_Mutation_p.G285S	NM_025185	NP_079461	Q9HCD6	TANC2_HUMAN	Homo sapiens tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 (TANC2), mRNA.	375							binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(15)|ovary(2)|upper_aerodigestive_tract(3)	44						CATTGGATTCGGCAAAACTGC	0.507												
EXOC7	23265	broad.mit.edu	37	17	74094004	74094004	+	Missense_Mutation	SNP	C	C	A			TCGA-06-0139-01A-01D-1490-08	TCGA-06-0139-10A-01D-1490-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c84ff17d-436d-49c1-aef2-b998ffe4a693	c739fdc7-b0df-4096-a7dd-50f519c9160f	g.chr17:74094004C>A	uc002jqs.3	-	4	608	c.513G>T	c.(511-513)ttG>ttT	p.L171F	EXOC7_uc010dgv.2_Missense_Mutation_p.L118F|EXOC7_uc010wsv.2_Missense_Mutation_p.L130F|EXOC7_uc010wsw.2_Missense_Mutation_p.L171F|EXOC7_uc002jqq.3_Missense_Mutation_p.L171F|EXOC7_uc010wsx.2_Missense_Mutation_p.L171F|EXOC7_uc002jqr.3_Missense_Mutation_p.L171F|EXOC7_uc002jqu.2_Missense_Mutation_p.L171F	NM_001145297	NP_001138769	Q9UPT5	EXOC7_HUMAN	Homo sapiens exocyst complex component 7 (EXOC7), transcript variant 4, mRNA.	171					exocytosis|protein transport	centriolar satellite|cytosol|exocyst|plasma membrane	protein binding			NS(1)|breast(2)|endometrium(1)|kidney(1)|large_intestine(4)|lung(4)|skin(1)	14			LUSC - Lung squamous cell carcinoma(166;0.187)			TGATCAGATCCAAGATGAGCA	0.602												
PCDHB3	56132	broad.mit.edu	37	5	140480851	140480851	+	Silent	SNP	G	G	A			TCGA-06-0139-01A-01D-1490-08	TCGA-06-0139-10A-01D-1490-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c84ff17d-436d-49c1-aef2-b998ffe4a693	c739fdc7-b0df-4096-a7dd-50f519c9160f	g.chr5:140480851G>A	uc003lio.3	+	0	618	c.618G>A	c.(616-618)ccG>ccA	p.P206P	BC016751_uc003lin.3_Intron	NM_018937	NP_061760	Q9Y5E6	PCDB3_HUMAN	Homo sapiens protocadherin beta 3 (PCDHB3), mRNA.	206	Cadherin 2.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding	p.Q205Q(1)		NS(2)|breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(19)|lung(24)|ovary(1)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	72			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			AGGAGCAGCCGGAACTCAGCT	0.567												
DIAPH1	1729	broad.mit.edu	37	5	140960406	140960406	+	Silent	SNP	C	C	A			TCGA-06-0139-01A-01D-1490-08	TCGA-06-0139-10A-01D-1490-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c84ff17d-436d-49c1-aef2-b998ffe4a693	c739fdc7-b0df-4096-a7dd-50f519c9160f	g.chr5:140960406C>A	uc003llb.4	-	7	870	c.729G>T	c.(727-729)ctG>ctT	p.L243L	DIAPH1_uc003llc.4_Silent_p.L234L|DIAPH1_uc021yep.1_Silent_p.L243L|DIAPH1_uc021yeq.1_Silent_p.L234L	NM_005219	NP_005210	O60610	DIAP1_HUMAN	Homo sapiens diaphanous homolog 1 (Drosophila) (DIAPH1), transcript variant 1, mRNA.	243	GBD/FH3.				regulation of microtubule-based process|sensory perception of sound	cytoplasm|cytoskeleton|ruffle membrane	actin binding|receptor binding|Rho GTPase binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(1)|lung(12)|pancreas(1)|skin(2)|stomach(2)	23			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTCTGACCAGCAGTAGGATTC	0.473												
PRSS55	203074	broad.mit.edu	37	8	10387101	10387101	+	Missense_Mutation	SNP	C	C	T			TCGA-06-0139-01A-01D-1490-08	TCGA-06-0139-10A-01D-1490-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c84ff17d-436d-49c1-aef2-b998ffe4a693	c739fdc7-b0df-4096-a7dd-50f519c9160f	g.chr8:10387101C>T	uc003wta.3	+	1	279	c.239C>T	c.(238-240)cCg>cTg	p.P80L	AK307207_uc010lru.3_Intron|PRSS55_uc022art.1_Missense_Mutation_p.P80L|PRSS55_uc003wtb.3_Non-coding_Transcript	NM_198464	NP_940866	Q6UWB4	PRS55_HUMAN	Homo sapiens protease, serine, 55 (PRSS55), transcript variant 1, mRNA.	80	Peptidase S1.				proteolysis	integral to membrane	serine-type endopeptidase activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(14)|ovary(1)|prostate(1)|skin(1)	31						GGTGAGTTTCCGTGGCAGGTG	0.512												
CYP7A1	1581	broad.mit.edu	37	8	59409488	59409488	+	Missense_Mutation	SNP	G	G	A			TCGA-06-0139-01A-01D-1490-08	TCGA-06-0139-10A-01D-1490-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c84ff17d-436d-49c1-aef2-b998ffe4a693	c739fdc7-b0df-4096-a7dd-50f519c9160f	g.chr8:59409488G>A	uc003xtm.4	-	2	646	c.583C>T	c.(583-585)Cgg>Tgg	p.R195W		NM_000780	NP_000771	P22680	CP7A1_HUMAN	Homo sapiens cytochrome P450, family 7, subfamily A, polypeptide 1 (CYP7A1), mRNA.	195					bile acid biosynthetic process|cellular lipid metabolic process|cellular response to cholesterol|cellular response to glucose stimulus|cholesterol catabolic process|cholesterol homeostasis|regulation of bile acid biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	cholesterol 7-alpha-monooxygenase activity|electron carrier activity|heme binding	p.R195L(1)		breast(4)|endometrium(1)|kidney(2)|large_intestine(5)|lung(19)|ovary(1)|prostate(1)|urinary_tract(1)	34		all_lung(136;0.0271)|Lung NSC(129;0.0351)|all_epithelial(80;0.0554)				TGTGTGTCCCGCCTTGTAAGA	0.453									Neonatal Giant Cell Hepatitis			
PSAT1	29968	broad.mit.edu	37	9	80921319	80921319	+	Missense_Mutation	SNP	G	G	A			TCGA-06-0139-01A-01D-1490-08	TCGA-06-0139-10A-01D-1490-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c84ff17d-436d-49c1-aef2-b998ffe4a693	c739fdc7-b0df-4096-a7dd-50f519c9160f	g.chr9:80921319G>A	uc004ala.3	+	4	555	c.487G>A	c.(487-489)Gac>Aac	p.D163N	PSAT1_uc004alb.3_Missense_Mutation_p.D163N	NM_058179	NP_478059	Q9Y617	SERC_HUMAN	Homo sapiens phosphoserine aminotransferase 1 (PSAT1), transcript variant 1, mRNA.	163					L-serine biosynthetic process|pyridoxine biosynthetic process		O-phospho-L-serine:2-oxoglutarate aminotransferase activity|pyridoxal phosphate binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(9)|ovary(1)|urinary_tract(1)	20					L-Glutamic Acid(DB00142)|Pyridoxal Phosphate(DB00114)|Pyridoxine(DB00165)	TGTGGAGTTTGACTTTATACC	0.463												
PSAT1	29968	broad.mit.edu	37	9	80921343	80921343	+	Missense_Mutation	SNP	G	G	A	rs115263053	by1000genomes	TCGA-06-0139-01A-01D-1490-08	TCGA-06-0139-10A-01D-1490-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c84ff17d-436d-49c1-aef2-b998ffe4a693	c739fdc7-b0df-4096-a7dd-50f519c9160f	g.chr9:80921343G>A	uc004ala.3	+	4	579	c.511G>A	c.(511-513)Gca>Aca	p.A171T	PSAT1_uc004alb.3_Missense_Mutation_p.A171T	NM_058179	NP_478059	Q9Y617	SERC_HUMAN	Homo sapiens phosphoserine aminotransferase 1 (PSAT1), transcript variant 1, mRNA.	171					L-serine biosynthetic process|pyridoxine biosynthetic process		O-phospho-L-serine:2-oxoglutarate aminotransferase activity|pyridoxal phosphate binding	p.G170*(1)		breast(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(9)|ovary(1)|urinary_tract(1)	20					L-Glutamic Acid(DB00142)|Pyridoxal Phosphate(DB00114)|Pyridoxine(DB00165)	TGTCAAGGGAGCAGTACTGGT	0.498												
TUBBP5	643224	broad.mit.edu	37	9	141070969	141070969	+	Silent	SNP	A	A	G			TCGA-06-0139-01A-01D-1490-08	TCGA-06-0139-10A-01D-1490-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c84ff17d-436d-49c1-aef2-b998ffe4a693	c739fdc7-b0df-4096-a7dd-50f519c9160f	g.chr9:141070969A>G	uc010ncq.3	+	4										Homo sapiens tubulin, beta pseudogene 5 (TUBBP5), non-coding RNA.									p.A196A(1)									TAGAAAACGCAGATGAGACCT	0.517