Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	isArtifactMode	oxoGCut
PRDM16	63976	broad.mit.edu	37	1	3342265	3342265	+	Silent	SNP	G	G	A			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr1:3342265G>A	uc001akf.2	+	13	3140	c.3060G>A	c.(3058-3060)CAG>CAA	p.Q1020Q	PRDM16_uc001akc.2_Silent_p.Q1019Q|PRDM16_uc001akd.2_Silent_p.Q1019Q|PRDM16_uc001ake.2_Silent_p.Q1020Q|PRDM16_uc009vlh.2_Silent_p.Q720Q	NM_022114	NP_071397	Q9HAZ2	PRD16_HUMAN	PR domain containing 16 isoform 1	1020	Mediates interaction with SKI and regulation of TGF-beta signaling.|C2H2-type 10.|Interaction with CTBP1 and CTBP2 (By similarity).				brown fat cell differentiation|negative regulation of granulocyte differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transforming growth factor beta receptor signaling pathway|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|regulation of cellular respiration|transcription, DNA-dependent	transcriptional repressor complex	protein binding|sequence-specific DNA binding|transcription coactivator activity|zinc ion binding			lung(3)|ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	7	all_cancers(77;0.00208)|all_epithelial(69;0.000732)|Ovarian(185;0.0634)|Lung NSC(156;0.109)|all_lung(157;0.111)	all_epithelial(116;2.03e-21)|all_lung(118;7.55e-09)|Lung NSC(185;1.28e-06)|Breast(487;0.000792)|Renal(390;0.00137)|Hepatocellular(190;0.00515)|Myeloproliferative disorder(586;0.0267)|Ovarian(437;0.0365)|Lung SC(97;0.114)|Medulloblastoma(700;0.134)		Epithelial(90;5.59e-35)|OV - Ovarian serous cystadenocarcinoma(86;1.99e-20)|GBM - Glioblastoma multiforme(42;3.72e-11)|Colorectal(212;0.000425)|BRCA - Breast invasive adenocarcinoma(365;0.000946)|COAD - Colon adenocarcinoma(227;0.000968)|Kidney(185;0.00155)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0175)|Lung(427;0.137)		TCGGGCAGCAGACCAACCTGG	0.647		NA	T	EVI1	MDS|AML								24	104					0	0	0	0
PLEKHM2	23207	broad.mit.edu	37	1	16046258	16046258	+	Silent	SNP	C	C	T			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr1:16046258C>T	uc010obo.1	+	6	722	c.495C>T	c.(493-495)TAC>TAT	p.Y165Y		NM_015164	NP_055979	Q8IWE5	PKHM2_HUMAN	pleckstrin homology domain containing, family M	165	Interaction with KIF5B.				Golgi organization	cytoplasm	kinesin binding			ovary(1)	1		Colorectal(325;0.000259)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.00057)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;9.18e-07)|COAD - Colon adenocarcinoma(227;4.5e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000133)|KIRC - Kidney renal clear cell carcinoma(229;0.00262)|STAD - Stomach adenocarcinoma(313;0.00774)|READ - Rectum adenocarcinoma(331;0.0657)		TGGCCCCCTACATGCCCGACT	0.587		NA											14	83					0	0	0	0
UBR4	23352	broad.mit.edu	37	1	19487411	19487411	+	Silent	SNP	C	C	T			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr1:19487411C>T	uc001bbi.2	-	38	5410	c.5406G>A	c.(5404-5406)CAG>CAA	p.Q1802Q	UBR4_uc001bbm.1_Silent_p.Q1013Q	NM_020765	NP_065816	Q5T4S7	UBR4_HUMAN	retinoblastoma-associated factor 600	1802					interspecies interaction between organisms	cytoplasm|cytoskeleton|integral to membrane|nucleus	calmodulin binding|ubiquitin-protein ligase activity|zinc ion binding			kidney(10)|ovary(7)|breast(4)|pancreas(2)|skin(2)	25		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000328)|Lung NSC(340;0.000406)|Breast(348;0.000814)|Ovarian(437;0.00774)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00674)|BRCA - Breast invasive adenocarcinoma(304;5.43e-05)|Kidney(64;0.000337)|KIRC - Kidney renal clear cell carcinoma(64;0.00426)|STAD - Stomach adenocarcinoma(196;0.00715)|READ - Rectum adenocarcinoma(331;0.0816)		TCAGCCCCACCTGGTTCTGTA	0.512		NA											12	36					0	0	0	0
ALPL	249	broad.mit.edu	37	1	21903944	21903944	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr1:21903944G>T	uc001bet.2	+	12	1635	c.1378G>T	c.(1378-1380)GCC>TCC	p.A460S	ALPL_uc010odn.1_Missense_Mutation_p.A408S|ALPL_uc010odo.1_Missense_Mutation_p.A405S|ALPL_uc010odp.1_Missense_Mutation_p.A383S|ALPL_uc001beu.3_Missense_Mutation_p.A460S	NM_000478	NP_000469	P05186	PPBT_HUMAN	tissue-nonspecific alkaline phosphatase	460					response to vitamin D|skeletal system development	anchored to membrane|cytoplasm|integral to membrane|plasma membrane	alkaline phosphatase activity|metal ion binding			ovary(2)|central_nervous_system(2)|skin(1)	5		all_lung(284;2.19e-05)|Lung NSC(340;2.22e-05)|Colorectal(325;3.46e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0192)|OV - Ovarian serous cystadenocarcinoma(117;8.7e-28)|COAD - Colon adenocarcinoma(152;1.57e-05)|GBM - Glioblastoma multiforme(114;2.66e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000177)|STAD - Stomach adenocarcinoma(196;0.00645)|KIRC - Kidney renal clear cell carcinoma(1967;0.00856)|READ - Rectum adenocarcinoma(331;0.0623)|Lung(427;0.146)	Amifostine(DB01143)	GGAGGACGTGGCCGTCTTCTC	0.667		NA											7	66					2.77e-08	2.99e-08	1	0
NRD1	4898	broad.mit.edu	37	1	52280475	52280475	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr1:52280475G>C	uc001ctc.3	-	14	1976	c.1654C>G	c.(1654-1656)CTT>GTT	p.L552V	NRD1_uc009vzb.2_Missense_Mutation_p.L247V|NRD1_uc001ctd.3_Missense_Mutation_p.L484V|NRD1_uc001cte.2_Missense_Mutation_p.L420V|NRD1_uc001ctf.2_Missense_Mutation_p.L484V|NRD1_uc010ong.1_RNA|NRD1_uc009vzc.1_Missense_Mutation_p.L352V	NM_002525	NP_002516	O43847	NRDC_HUMAN	nardilysin isoform a	483					cell migration|cell proliferation|neuromuscular junction development|positive regulation of membrane protein ectodomain proteolysis|proteolysis|regulation of endopeptidase activity	cell surface|cytosol	epidermal growth factor binding|metalloendopeptidase activity|zinc ion binding				0						AACAGTGCAAGAGCCCAGCAT	0.378		NA											11	54					0	0	0	0
C1orf168	199920	broad.mit.edu	37	1	57254662	57254662	+	Silent	SNP	G	G	A			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr1:57254662G>A	uc001cym.3	-	3	1309	c.903C>T	c.(901-903)CCC>CCT	p.P301P	C1orf168_uc009vzu.1_RNA|C1orf168_uc009vzv.1_Silent_p.P301P	NM_001004303	NP_001004303	Q5VWT5	CA168_HUMAN	hypothetical protein LOC199920	301										ovary(3)|skin(2)	5						CCTGAGTCTTGGGAACAGCAG	0.602		NA											38	158					0	0	0	0
WLS	79971	broad.mit.edu	37	1	68659750	68659750	+	Silent	SNP	G	G	A			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr1:68659750G>A	uc001def.1	-	2	538	c.267C>T	c.(265-267)GAC>GAT	p.D89D	uc001deb.1_Intron|uc001dec.1_Intron|WLS_uc001dee.2_Silent_p.D87D|WLS_uc001deg.1_Intron|WLS_uc001deh.1_Silent_p.D89D|WLS_uc009wbf.1_Silent_p.D44D	NM_024911	NP_079187	Q5T9L3	WLS_HUMAN	G protein-coupled receptor 177 isoform 1	89	Lumenal (Potential).				multicellular organismal development|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|Wnt receptor signaling pathway	cytoplasmic vesicle membrane|Golgi membrane|integral to membrane	signal transducer activity				0						AAAACACGATGTCATTGGCTT	0.463		NA											18	86					0	0	0	0
NBPF10	100132406	broad.mit.edu	37	1	145302714	145302714	+	Silent	SNP	A	A	G	rs9424867		TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr1:145302714A>G	uc001end.3	+	8	1187	c.1152A>G	c.(1150-1152)TTA>TTG	p.L384L	NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|NBPF10_uc001emp.3_Intron|NBPF10_uc010oyi.1_5'UTR|NBPF10_uc001emq.1_Silent_p.L113L	NM_001039703	NP_001034792	A6NDV3	A6NDV3_HUMAN	hypothetical protein LOC100132406	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment											0	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		AGGAGAAGTTACGGGAAGGGA	0.527		NA											7	236					0	0	0	0
MTMR11	10903	broad.mit.edu	37	1	149905309	149905309	+	Silent	SNP	G	G	A			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr1:149905309G>A	uc001etl.3	-	10	1226	c.975C>T	c.(973-975)CTC>CTT	p.L325L	MTMR11_uc001etm.1_Silent_p.L253L|MTMR11_uc010pbm.1_Silent_p.L297L|MTMR11_uc010pbn.1_Silent_p.L167L	NM_001145862	NP_001139334	A4FU01	MTMRB_HUMAN	myotubularin related protein 11 isoform a	325	Myotubularin phosphatase.						phosphatase activity			central_nervous_system(1)	1	Breast(34;0.0009)|Ovarian(49;0.0377)|all_hematologic(923;0.0597)|Hepatocellular(266;0.161)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.221)|STAD - Stomach adenocarcinoma(528;0.247)			CAGGCAGGCAGAGGGCCCTCA	0.557		NA											57	188					0	0	0	0
ARNT	405	broad.mit.edu	37	1	150808789	150808789	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr1:150808789C>T	uc001evr.1	-	7	810	c.667G>A	c.(667-669)GAG>AAG	p.E223K	ARNT_uc001evs.1_Missense_Mutation_p.E208K|ARNT_uc009wmb.1_Missense_Mutation_p.E214K|ARNT_uc009wmc.1_Missense_Mutation_p.E223K|ARNT_uc009wmd.1_Missense_Mutation_p.E208K|ARNT_uc009wme.1_Missense_Mutation_p.E223K|ARNT_uc010pcl.1_Missense_Mutation_p.E207K	NM_001668	NP_001659	P27540	ARNT_HUMAN	aryl hydrocarbon receptor nuclear translocator	223	PAS 1.				positive regulation of hormone biosynthetic process|positive regulation vascular endothelial growth factor production|regulation of transcription from RNA polymerase II promoter in response to oxidative stress|response to hypoxia		aryl hydrocarbon receptor binding|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription coactivator activity			skin(4)|lung(3)|central_nervous_system(1)|kidney(1)	9	all_lung(15;9e-35)|Lung NSC(24;3.45e-31)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.108)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.02)|BRCA - Breast invasive adenocarcinoma(12;0.00606)|LUSC - Lung squamous cell carcinoma(543;0.211)			GAAAGCTGCTCACGAAGTTTA	0.448		NA	T	ETV6	AML								28	84					0	0	0	0
MRPL9	65005	broad.mit.edu	37	1	151732598	151732598	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr1:151732598C>A	uc001eyv.2	-	7	817	c.732G>T	c.(730-732)AAG>AAT	p.K244N	MRPL9_uc009wmz.2_RNA	NM_031420	NP_113608	Q9BYD2	RM09_HUMAN	mitochondrial ribosomal protein L9 precursor	244					translation	mitochondrial ribosome	structural constituent of ribosome			ovary(1)	1	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.14)		LUSC - Lung squamous cell carcinoma(543;0.181)			ATCTTTTGGTCTTGGGCTTCT	0.493		NA											25	70					1.64e-13	1.82e-13	1	0
ATP8B2	57198	broad.mit.edu	37	1	154309988	154309988	+	Silent	SNP	C	C	A			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr1:154309988C>A	uc001fey.1	+	11	1248	c.1059C>A	c.(1057-1059)CTC>CTA	p.L353L	ATP8B2_uc001few.2_Silent_p.L334L|ATP8B2_uc001fex.2_Silent_p.L367L	NM_001005855	NP_001005855	P98198	AT8B2_HUMAN	ATPase, class I, type 8B, member 2 isoform b	353	Helical; (Potential).				ATP biosynthetic process	plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(1)|skin(1)	2	all_lung(78;2.62e-30)|Lung NSC(65;3.94e-28)|Hepatocellular(266;0.0877)		LUSC - Lung squamous cell carcinoma(543;0.185)			TCATCATCCTCAACACCGTTG	0.532		NA											117	403					1.39e-60	1.57e-60	1	0
PBXIP1	57326	broad.mit.edu	37	1	154926182	154926182	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr1:154926182C>T	uc001ffr.2	-	2	75	c.16G>A	c.(16-18)GAC>AAC	p.D6N	PBXIP1_uc001ffs.2_Intron|PBXIP1_uc010pep.1_Intron|PBXIP1_uc009woy.1_RNA	NM_020524	NP_065385	Q96AQ6	PBIP1_HUMAN	pre-B-cell leukemia homeobox interacting protein	6					cell differentiation|multicellular organismal development|negative regulation of transcription, DNA-dependent	cytosol|microtubule|nucleus	protein binding|transcription corepressor activity			large_intestine(1)	1	all_epithelial(22;4.9e-30)|all_lung(78;4.1e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)|all_neural(408;0.245)		BRCA - Breast invasive adenocarcinoma(34;0.00034)			TTATCAGAGTCTGGGCAGGAG	0.607		NA											10	24					0	0	0	0
USH2A	7399	broad.mit.edu	37	1	216369938	216369938	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr1:216369938G>A	uc001hku.1	-	19	4595	c.4208C>T	c.(4207-4209)TCT>TTT	p.S1403F	USH2A_uc001hkv.2_Missense_Mutation_p.S1403F	NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	1403	Extracellular (Potential).|Fibronectin type-III 4.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		TGATTGTTCAGAAAGCATATT	0.408		NA								HNSCC(13;0.011)			39	129					0	0	0	0
CHML	1122	broad.mit.edu	37	1	241798757	241798757	+	Silent	SNP	G	G	A	rs113330678		TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr1:241798757G>A	uc001hzd.2	-	1	476	c.312C>T	c.(310-312)TAC>TAT	p.Y104Y	OPN3_uc001hza.2_Intron|OPN3_uc001hzb.2_Intron|OPN3_uc001hzc.2_Intron	NM_001821	NP_001812	P26374	RAE2_HUMAN	choroideremia-like Rab escort protein 2	104					intracellular protein transport|visual perception	Rab-protein geranylgeranyltransferase complex	GTPase activator activity|Rab geranylgeranyltransferase activity			ovary(4)|skin(2)	6	Ovarian(103;0.103)|all_lung(81;0.23)	all_cancers(173;0.0231)	OV - Ovarian serous cystadenocarcinoma(106;0.0125)			CCTGACTGGCGTAGCAAAAAG	0.438		NA											116	342					0	0	0	0
OR2W3	343171	broad.mit.edu	37	1	248059077	248059077	+	Silent	SNP	C	C	T			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr1:248059077C>T	uc001idp.1	+	3	458	c.189C>T	c.(187-189)CTC>CTT	p.L63L	OR2W3_uc010pzb.1_Silent_p.L63L	NM_001001957	NP_001001957	Q7Z3T1	OR2W3_HUMAN	olfactory receptor, family 2, subfamily W,	63	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|breast(1)|pancreas(1)	3	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0319)			ACTTCTTCCTCGCCCACCTTT	0.572		NA											49	261					0	0	0	0
CAMK1D	57118	broad.mit.edu	37	10	12866500	12866500	+	Silent	SNP	C	C	T			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr10:12866500C>T	uc001ilo.2	+	9	1105	c.870C>T	c.(868-870)CAC>CAT	p.H290H	CAMK1D_uc001iln.2_Silent_p.H290H	NM_153498	NP_705718	Q8IU85	KCC1D_HUMAN	calcium/calmodulin-dependent protein kinase ID	290	Autoinhibitory domain (By similarity).					calcium- and calmodulin-dependent protein kinase complex|cytoplasm|nucleus	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			ovary(1)|stomach(1)	2				GBM - Glioblastoma multiforme(1;3.16e-05)		AAAACATCCACGAGTCCGTCA	0.517		NA											7	42					0	0	0	0
RHOBTB1	9886	broad.mit.edu	37	10	62670718	62670718	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr10:62670718C>T	uc001jli.2	-	5	661	c.223G>A	c.(223-225)GAA>AAA	p.E75K	RHOBTB1_uc001jlh.2_Missense_Mutation_p.E75K|RHOBTB1_uc001jlj.2_Missense_Mutation_p.E75K|RHOBTB1_uc001jlk.2_Missense_Mutation_p.E75K|RHOBTB1_uc009xpe.1_Missense_Mutation_p.E75K|RHOBTB1_uc001jlm.2_Missense_Mutation_p.E75K	NM_014836	NP_055651	O94844	RHBT1_HUMAN	Rho-related BTB domain containing 1	75	Rho-like.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|plasma membrane	GTP binding			upper_aerodigestive_tract(1)	1	Prostate(12;0.0112)					ACACTCACTTCATCAACAACA	0.488		NA											17	75					0	0	0	0
CCAR1	55749	broad.mit.edu	37	10	70520875	70520875	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr10:70520875G>C	uc001joo.2	+	16	2151	c.2032G>C	c.(2032-2034)GAA>CAA	p.E678Q	CCAR1_uc001jol.1_RNA|CCAR1_uc001jom.1_Missense_Mutation_p.E483Q|CCAR1_uc009xpx.1_Missense_Mutation_p.E652Q|CCAR1_uc001jon.1_Missense_Mutation_p.E624Q|CCAR1_uc010qiz.1_Missense_Mutation_p.E663Q|CCAR1_uc010qja.1_Missense_Mutation_p.E663Q|CCAR1_uc010qjb.1_RNA	NM_018237	NP_060707	Q8IX12	CCAR1_HUMAN	cell-cycle and apoptosis regulatory protein 1	678	Glu-rich.				apoptosis|cell cycle|nuclear mRNA splicing, via spliceosome|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm|perinuclear region of cytoplasm	calcium ion binding|nucleic acid binding|protein binding			ovary(6)|large_intestine(1)	7						ACAAAAAGAAGAACAGAAGGA	0.348		NA											33	99					0	0	0	0
USP54	159195	broad.mit.edu	37	10	75331188	75331188	+	Silent	SNP	G	G	A			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr10:75331188G>A	uc001juo.2	-	2	248	c.231C>T	c.(229-231)TGC>TGT	p.C77C	USP54_uc001jup.2_Silent_p.C77C|USP54_uc010qkl.1_Silent_p.C77C	NM_152586	NP_689799	Q70EL1	UBP54_HUMAN	ubiquitin specific peptidase 54	77					ubiquitin-dependent protein catabolic process		protein binding|ubiquitin thiolesterase activity			breast(3)|lung(2)|kidney(1)	6	Prostate(51;0.0112)					CCTTGAGAGCGCAAAAGATGC	0.433		NA											4	134					0	0	0	0
TM9SF3	56889	broad.mit.edu	37	10	98311125	98311125	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr10:98311125C>G	uc001kmm.3	-	7	1053	c.836G>C	c.(835-837)GGA>GCA	p.G279A	TM9SF3_uc010qot.1_Missense_Mutation_p.G279A|TM9SF3_uc001kmn.1_Missense_Mutation_p.G48A	NM_020123	NP_064508	Q9HD45	TM9S3_HUMAN	transmembrane 9 superfamily member 3 precursor	279						integral to membrane	binding				0		Colorectal(252;0.158)		Epithelial(162;1.84e-09)|all cancers(201;2.84e-08)		AAATACATCTCCATGCACCTG	0.353		NA											34	157					0	0	0	0
POLL	27343	broad.mit.edu	37	10	103344392	103344392	+	Silent	SNP	G	G	A	rs41540413		TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr10:103344392G>A	uc001ktg.1	-	4	1624	c.858C>T	c.(856-858)CTC>CTT	p.L286L	DPCD_uc010qpz.1_Intron|POLL_uc001ktd.1_5'Flank|POLL_uc001kte.1_5'Flank|POLL_uc001kth.1_Intron|POLL_uc001kti.1_Silent_p.L286L|POLL_uc001ktj.1_Silent_p.L286L|POLL_uc001ktf.2_Intron|POLL_uc001ktk.1_Intron|POLL_uc010qqa.1_Intron|POLL_uc010qqb.1_Intron|POLL_uc001ktm.2_Silent_p.L286L|POLL_uc001ktl.2_Silent_p.L198L|POLL_uc010qqc.1_Intron|POLL_uc010qqd.1_Missense_Mutation_p.S144L	NM_013274	NP_037406	Q9UGP5	DPOLL_HUMAN	DNA-directed DNA polymerase lambda	286					DNA replication|nucleotide-excision repair|somatic hypermutation of immunoglobulin genes	nucleus	DNA binding|DNA-directed DNA polymerase activity|lyase activity|metal ion binding				0		Colorectal(252;0.234)		Epithelial(162;1.55e-08)|all cancers(201;6.64e-07)		GGAAGCTCTTGAGGGCATTGA	0.562		NA						DNA_polymerases_(catalytic_subunits)					42	107					0	0	0	0
POLL	27343	broad.mit.edu	37	10	103344516	103344516	+	Nonsense_Mutation	SNP	G	G	C			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr10:103344516G>C	uc001ktg.1	-	4	1500	c.734C>G	c.(733-735)TCA>TGA	p.S245*	DPCD_uc010qpz.1_Intron|POLL_uc001ktd.1_5'Flank|POLL_uc001kte.1_5'Flank|POLL_uc001kth.1_Intron|POLL_uc001kti.1_Nonsense_Mutation_p.S245*|POLL_uc001ktj.1_Nonsense_Mutation_p.S245*|POLL_uc001ktf.2_Intron|POLL_uc001ktk.1_Intron|POLL_uc010qqa.1_Intron|POLL_uc010qqb.1_Intron|POLL_uc001ktm.2_Nonsense_Mutation_p.S245*|POLL_uc001ktl.2_Nonsense_Mutation_p.S157*|POLL_uc010qqc.1_Intron|POLL_uc010qqd.1_Missense_Mutation_p.Q103E	NM_013274	NP_037406	Q9UGP5	DPOLL_HUMAN	DNA-directed DNA polymerase lambda	245					DNA replication|nucleotide-excision repair|somatic hypermutation of immunoglobulin genes	nucleus	DNA binding|DNA-directed DNA polymerase activity|lyase activity|metal ion binding				0		Colorectal(252;0.234)		Epithelial(162;1.55e-08)|all cancers(201;6.64e-07)		CTTCTGGCTTGAGGGCTGTGC	0.582		NA						DNA_polymerases_(catalytic_subunits)					26	66					0	0	0	0
ACADSB	36	broad.mit.edu	37	10	124803982	124803982	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr10:124803982G>C	uc001lhb.2	+	7	998	c.881G>C	c.(880-882)AGA>ACA	p.R294T	ACADSB_uc010qub.1_Missense_Mutation_p.R192T	NM_001609	NP_001600	P45954	ACDSB_HUMAN	acyl-Coenzyme A dehydrogenase, short/branched	294	Substrate binding.				branched chain family amino acid catabolic process|fatty acid metabolic process	mitochondrial matrix	flavin adenine dinucleotide binding			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	3		all_neural(114;0.0765)|Colorectal(57;0.102)|all_lung(145;0.11)|Lung NSC(174;0.163)		Colorectal(40;0.0811)|COAD - Colon adenocarcinoma(40;0.0835)	L-Isoleucine(DB00167)	AATGAAGGTAGAATAGGAATT	0.358		NA											20	72					0	0	0	0
C10orf137	26098	broad.mit.edu	37	10	127414362	127414362	+	Silent	SNP	C	C	T	rs150180630	byFrequency	TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr10:127414362C>T	uc001liq.1	+	6	1040	c.747C>T	c.(745-747)TTC>TTT	p.F249F	C10orf137_uc001lin.2_Silent_p.F249F|C10orf137_uc001lio.1_Silent_p.F249F|C10orf137_uc001lip.1_5'UTR	NM_015608	NP_056423	Q3B7T1	EDRF1_HUMAN	erythroid differentiation-related factor 1	249					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	binding			ovary(5)|large_intestine(3)|lung(2)	10		all_lung(145;0.0096)|Lung NSC(174;0.0145)|Colorectal(57;0.0846)|all_neural(114;0.0936)				CTGCTCCCTTCGAAATGCCTT	0.463		NA											21	76					0	0	0	0
OR52J3	119679	broad.mit.edu	37	11	5068023	5068023	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr11:5068023G>C	uc010qyv.1	+	1	268	c.268G>C	c.(268-270)GAT>CAT	p.D90H		NM_001001916	NP_001001916	Q8NH60	O52J3_HUMAN	olfactory receptor, family 52, subfamily J,	90	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|lung(1)|skin(1)	3		Medulloblastoma(188;0.00131)|all_neural(188;0.0189)|Breast(177;0.0204)		Epithelial(150;9.29e-10)|BRCA - Breast invasive adenocarcinoma(625;0.135)|LUSC - Lung squamous cell carcinoma(625;0.19)		CTTCTGGTTTGATGCTCACGA	0.498		NA											19	112					0	0	0	0
KIF18A	81930	broad.mit.edu	37	11	28104463	28104463	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr11:28104463G>C	uc001msc.2	-	9	1384	c.1202C>G	c.(1201-1203)ACT>AGT	p.T401S		NM_031217	NP_112494	Q8NI77	KI18A_HUMAN	kinesin family member 18A	401	Potential.				blood coagulation|microtubule depolymerization|microtubule-based movement|mitotic metaphase plate congression|mitotic prometaphase|protein transport	caveola|cytosol|kinetochore microtubule|microtubule organizing center|nucleus|ruffle	actin binding|ATP binding|microtubule plus-end binding|plus-end-directed microtubule motor activity|tubulin-dependent ATPase activity|ubiquitin binding			ovary(2)	2						ATTTTCATTAGTGAAGGCTTT	0.279		NA											23	75					0	0	0	0
APLNR	187	broad.mit.edu	37	11	57004030	57004030	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr11:57004030G>A	uc001njo.2	-	1	898	c.449C>T	c.(448-450)ACG>ATG	p.T150M	APLNR_uc001njn.3_RNA	NM_005161	NP_005152	P35414	APJ_HUMAN	apelin receptor	150	Helical; Name=4; (Potential).					integral to plasma membrane	G-protein coupled receptor activity			lung(5)|ovary(1)	6						AAGAACTGCCGTGGCCACGGC	0.647		NA											5	33					0	0	0	0
VWCE	220001	broad.mit.edu	37	11	61039224	61039224	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr11:61039224G>C	uc001nra.2	-	14	1987	c.1708C>G	c.(1708-1710)CTT>GTT	p.L570V	VWCE_uc001nrb.2_RNA	NM_152718	NP_689931	Q96DN2	VWCE_HUMAN	von Willebrand factor C and EGF domains	570	VWFC 4.					extracellular region	calcium ion binding			ovary(1)	1						TTGTCGTCAAGAGAGCAGCCT	0.498		NA											2	16					0	0	0	0
LGALS12	85329	broad.mit.edu	37	11	63283757	63283757	+	Silent	SNP	G	G	A			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr11:63283757G>A	uc001nxa.2	+	9	1244	c.903G>A	c.(901-903)GCG>GCA	p.A301A	LGALS12_uc001nxb.2_Silent_p.A292A|LGALS12_uc001nxc.2_Silent_p.A302A|LGALS12_uc001nxd.2_Silent_p.A240A|LGALS12_uc001nxe.2_Silent_p.A231A|LGALS12_uc009yot.2_Silent_p.A261A	NM_033101	NP_149092	Q96DT0	LEG12_HUMAN	lectin, galactoside-binding, soluble, 12 isoform	301	Galectin 2.				apoptosis|induction of apoptosis by intracellular signals	nucleus	lactose binding			ovary(2)	2						TGAAGCTGGCGCTCAATGGGC	0.632		NA											19	50					0	0	0	0
PYGM	5837	broad.mit.edu	37	11	64519416	64519416	+	Missense_Mutation	SNP	T	T	A			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr11:64519416T>A	uc001oax.3	-	14	2565	c.1748A>T	c.(1747-1749)CAT>CTT	p.H583L	PYGM_uc001oay.3_Missense_Mutation_p.H495L	NM_005609	NP_005600	P11217	PYGM_HUMAN	muscle glycogen phosphorylase isoform 1	583					glucose metabolic process|glycogen catabolic process	cytosol	glycogen phosphorylase activity|protein binding			ovary(2)	2					Pyridoxal Phosphate(DB00114)	GGTGATGACATGGAGGCAGTT	0.502		NA											20	95					0	0	0	0
CCDC67	159989	broad.mit.edu	37	11	93148192	93148192	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr11:93148192G>A	uc001pdq.2	+	13	1650	c.1550G>A	c.(1549-1551)AGA>AAA	p.R517K	CCDC67_uc001pdo.1_Missense_Mutation_p.R517K	NM_181645	NP_857596	Q05D60	CCD67_HUMAN	coiled-coil domain containing 67	517										ovary(1)	1		Acute lymphoblastic leukemia(157;2.35e-05)|all_hematologic(158;0.00824)				GAGCCAAACAGAAGTACAATG	0.398		NA											91	113					0	0	0	0
C11orf88	399949	broad.mit.edu	37	11	111385713	111385713	+	Silent	SNP	G	G	C			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr11:111385713G>C	uc001pln.3	+	1	204	c.204G>C	c.(202-204)CGG>CGC	p.R68R	BTG4_uc001plj.2_5'Flank|BTG4_uc001plk.2_5'Flank|C11orf88_uc009yyd.2_Silent_p.R68R|C11orf88_uc001plo.1_Silent_p.R68R	NM_001100388	NP_001093858	Q6PI97	CK088_HUMAN	hypothetical protein LOC399949 isoform 2	68											0						CGGTGGCGCGGCCCAGGAGGA	0.602		NA									OREG0021329	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	17	70					0	0	0	0
SLC6A13	6540	broad.mit.edu	37	12	333247	333247	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr12:333247G>A	uc001qic.1	-	11	1275	c.1222C>T	c.(1222-1224)CAC>TAC	p.H408Y	SLC6A13_uc009zdj.1_Missense_Mutation_p.H398Y|SLC6A13_uc010sdl.1_Missense_Mutation_p.H316Y	NM_016615	NP_057699	Q9NSD5	S6A13_HUMAN	solute carrier family 6 (neurotransmitter	408					neurotransmitter secretion	integral to plasma membrane	gamma-aminobutyric acid:sodium symporter activity|neurotransmitter:sodium symporter activity				0	all_cancers(10;0.0416)|all_epithelial(11;0.0537)|all_lung(10;0.0989)|Lung NSC(10;0.139)|Ovarian(42;0.142)		OV - Ovarian serous cystadenocarcinoma(31;0.00153)|BRCA - Breast invasive adenocarcinoma(9;0.239)			CGGAACACGTGAGGGTACATG	0.562		NA											25	61					0	0	0	0
CHD4	1108	broad.mit.edu	37	12	6691446	6691446	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr12:6691446C>T	uc001qpo.2	-	30	4536	c.4372G>A	c.(4372-4374)GCA>ACA	p.A1458T	CHD4_uc001qpn.2_Missense_Mutation_p.A1451T|CHD4_uc001qpp.2_Missense_Mutation_p.A1483T|uc001qpq.1_Intron|SCARNA11_uc001qpr.1_5'Flank	NM_001273	NP_001264	Q14839	CHD4_HUMAN	chromodomain helicase DNA binding protein 4	1458					chromatin modification|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	microtubule organizing center|NuRD complex	ATP binding|ATP-dependent DNA helicase activity|DNA binding|zinc ion binding			central_nervous_system(2)	2						GAGACATATGCCCTGTGTAAA	0.488		NA											21	70					0	0	0	0
ATN1	1822	broad.mit.edu	37	12	7045557	7045557	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr12:7045557C>T	uc001qrw.1	+	5	1364	c.1127C>T	c.(1126-1128)TCA>TTA	p.S376L	ATN1_uc001qrx.1_Missense_Mutation_p.S376L|ATN1_uc001qry.1_Missense_Mutation_p.S375L	NM_001007026	NP_001007027	P54259	ATN1_HUMAN	atrophin-1	376	Poly-Ser.				cell death|central nervous system development	cytoplasm|nucleus	protein domain specific binding			ovary(2)|breast(2)|pancreas(1)|skin(1)	6						TTTCCTTATTCATCCTCTAGT	0.463		NA											44	134					0	0	0	0
MLL2	8085	broad.mit.edu	37	12	49434325	49434325	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr12:49434325G>A	uc001rta.3	-	31	7228	c.7228C>T	c.(7228-7230)CGA>TGA	p.R2410*		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	2410	Pro-rich.				chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						GCAGGCACTCGGGAGAAAGGG	0.647		NA	N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			8	41					0	0	0	0
ESPL1	9700	broad.mit.edu	37	12	53680494	53680494	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr12:53680494C>T	uc001sck.2	+	18	4065	c.3974C>T	c.(3973-3975)TCT>TTT	p.S1325F	ESPL1_uc001scj.2_Missense_Mutation_p.S1000F|ESPL1_uc010soe.1_Intron	NM_012291	NP_036423	Q14674	ESPL1_HUMAN	separase	1325					apoptosis|cytokinesis|establishment of mitotic spindle localization|mitotic sister chromatid segregation|negative regulation of sister chromatid cohesion|positive regulation of mitotic metaphase/anaphase transition|proteolysis	centrosome|nucleus	cysteine-type peptidase activity|protein binding			lung(1)|kidney(1)|skin(1)	3						AAGTTAGCCTCTGCTCCCCTG	0.562		NA											16	49					0	0	0	0
ARHGAP9	64333	broad.mit.edu	37	12	57872434	57872434	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr12:57872434C>G	uc001sod.2	-	6	829	c.636G>C	c.(634-636)AGG>AGC	p.R212S	ARHGAP9_uc001snz.2_5'Flank|ARHGAP9_uc001soa.2_5'Flank|ARHGAP9_uc001sob.2_Missense_Mutation_p.R141S|ARHGAP9_uc001soc.2_Missense_Mutation_p.R141S|ARHGAP9_uc001soe.1_Missense_Mutation_p.R220S|ARHGAP9_uc010sro.1_Missense_Mutation_p.R141S	NM_032496	NP_115885	Q9BRR9	RHG09_HUMAN	Rho GTPase activating protein 9 isoform 1	141					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|protein binding			lung(1)	1			GBM - Glioblastoma multiforme(3;3.37e-34)			TGCTGACGCTCCTACACATTT	0.577		NA											38	158					0	0	0	0
FAM19A2	338811	broad.mit.edu	37	12	62261196	62261196	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr12:62261196C>G	uc001sqw.2	-	2	1524	c.11G>C	c.(10-12)AGA>ACA	p.R4T	FAM19A2_uc001sqx.2_Missense_Mutation_p.R4T|FAM19A2_uc001sqy.2_RNA	NM_178539	NP_848634	Q8N3H0	F19A2_HUMAN	family with sequence similarity 19 (chemokine	4						cytoplasm				ovary(1)	1			GBM - Glioblastoma multiforme(1;0.00484)	GBM - Glioblastoma multiforme(3;0.02)		CTGTAAGTATCTCTTACTCAT	0.313		NA											23	113					0	0	0	0
CPM	1368	broad.mit.edu	37	12	69250400	69250400	+	Silent	SNP	C	C	T			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr12:69250400C>T	uc001sup.2	-	9	1210	c.1149G>A	c.(1147-1149)CAG>CAA	p.Q383Q	CPM_uc001sur.2_Silent_p.Q383Q|CPM_uc001suq.2_Silent_p.Q383Q	NM_198320	NP_938079	P14384	CBPM_HUMAN	carboxypeptidase M precursor	383					anatomical structure morphogenesis|proteolysis	anchored to membrane|cytoplasm|nucleus|plasma membrane	metallocarboxypeptidase activity|zinc ion binding				0	all_epithelial(5;1.09e-35)|Lung NSC(4;1.47e-33)|all_lung(4;1.02e-31)|Breast(13;1.59e-06)		all cancers(2;2.69e-50)|GBM - Glioblastoma multiforme(2;7.34e-41)|BRCA - Breast invasive adenocarcinoma(5;5.38e-10)|Lung(24;4.61e-05)|LUAD - Lung adenocarcinoma(15;0.000376)|STAD - Stomach adenocarcinoma(21;0.00372)|Kidney(9;0.143)			CACTGAAGTTCTGGGATTTCT	0.393		NA											32	124					0	0	0	0
CDK17	5128	broad.mit.edu	37	12	96691104	96691104	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr12:96691104C>G	uc001tep.1	-	9	1306	c.817G>C	c.(817-819)GAC>CAC	p.D273H	CDK17_uc009ztk.2_Missense_Mutation_p.D273H|CDK17_uc010svb.1_Missense_Mutation_p.D220H	NM_002595	NP_002586	Q00537	CDK17_HUMAN	PCTAIRE protein kinase 2	273	Protein kinase.						ATP binding|cyclin-dependent protein kinase activity			ovary(3)|lung(2)|kidney(1)|central_nervous_system(1)	7						TGTTTCAGGTCTTTATCCTGG	0.338		NA											9	67					0	0	0	0
MYBPC1	4604	broad.mit.edu	37	12	102046500	102046500	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr12:102046500G>C	uc001tii.2	+	15	1598	c.1496G>C	c.(1495-1497)GGT>GCT	p.G499A	MYBPC1_uc001tig.2_Missense_Mutation_p.G524A|MYBPC1_uc010svq.1_Missense_Mutation_p.G486A|MYBPC1_uc001tih.2_Missense_Mutation_p.G524A|MYBPC1_uc001tij.2_Missense_Mutation_p.G499A|MYBPC1_uc010svr.1_Missense_Mutation_p.G499A|MYBPC1_uc010svs.1_Missense_Mutation_p.G499A|MYBPC1_uc010svt.1_Missense_Mutation_p.G487A|MYBPC1_uc010svu.1_Missense_Mutation_p.G480A|MYBPC1_uc001tik.2_Missense_Mutation_p.G473A	NM_206820	NP_996556	Q00872	MYPC1_HUMAN	myosin binding protein C, slow type isoform 3	499	Ig-like C2-type 4.				cell adhesion|muscle filament sliding	cytosol|myofibril|myosin filament	actin binding|structural constituent of muscle|titin binding			ovary(2)|liver(1)|skin(1)	4						GAAGATGAAGGTGATTATGTA	0.358		NA											54	199					0	0	0	0
STAB2	55576	broad.mit.edu	37	12	104064480	104064480	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr12:104064480G>C	uc001tjw.2	+	22	2452	c.2266G>C	c.(2266-2268)GAT>CAT	p.D756H		NM_017564	NP_060034	Q8WWQ8	STAB2_HUMAN	stabilin 2 precursor	756	Extracellular (Potential).|EGF-like 6.				angiogenesis|cell adhesion|defense response to bacterium|receptor-mediated endocytosis	cytoplasm|external side of plasma membrane|integral to plasma membrane	Gram-negative bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			ovary(9)|skin(5)	14						CCAGTGTGCAGATAGCCTCGG	0.502		NA											11	28					0	0	0	0
CKAP4	10970	broad.mit.edu	37	12	106633144	106633144	+	Silent	SNP	C	C	T			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr12:106633144C>T	uc001tlk.2	-	2	1551	c.1467G>A	c.(1465-1467)CTG>CTA	p.L489L		NM_006825	NP_006816	Q07065	CKAP4_HUMAN	cytoskeleton-associated protein 4	489						ER-Golgi intermediate compartment membrane|integral to membrane|membrane fraction					0						CACTCCTCTTCAGCTCCTCCA	0.662		NA											32	89					0	0	0	0
SFRS8	6433	broad.mit.edu	37	12	132195869	132195869	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr12:132195869G>A	uc001uja.1	+	1	235	c.95G>A	c.(94-96)CGA>CAA	p.R32Q	SFRS8_uc010tbn.1_Missense_Mutation_p.R32Q|SFRS8_uc001ujb.1_5'UTR|SFRS8_uc001uiz.1_5'UTR	NM_004592	NP_004583	Q12872	SFSWA_HUMAN	splicing factor, arginine/serine-rich 8	32					mRNA splice site selection|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding|RNA binding				0	all_neural(191;0.0982)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;3.44e-07)|Epithelial(86;2.94e-06)|all cancers(50;4.82e-05)		GGGGGCAGCCGAGTGGAGCTC	0.697		NA											8	32					0	0	0	0
SLC7A1	6541	broad.mit.edu	37	13	30096553	30096553	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr13:30096553C>G	uc001uso.2	-	8	1477	c.1090G>C	c.(1090-1092)GCC>CCC	p.A364P		NM_003045	NP_003036	P30825	CTR1_HUMAN	solute carrier family 7 (cationic amino acid	364	Cytoplasmic (Potential).				cellular nitrogen compound metabolic process|ion transport	integral to plasma membrane	receptor activity				0		Lung SC(185;0.0257)|Breast(139;0.238)		all cancers(112;0.0148)|OV - Ovarian serous cystadenocarcinoma(117;0.0554)|Epithelial(112;0.0875)|GBM - Glioblastoma multiforme(144;0.179)	L-Arginine(DB00125)|L-Lysine(DB00123)|L-Ornithine(DB00129)	TCAGCCATGGCATAGATAACC	0.498		NA											30	150					0	0	0	0
PCDH9	5101	broad.mit.edu	37	13	67800883	67800883	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr13:67800883C>A	uc001vik.2	-	2	2382	c.1690G>T	c.(1690-1692)GAT>TAT	p.D564Y	PCDH9_uc001vil.2_Missense_Mutation_p.D564Y|PCDH9_uc010thl.1_Missense_Mutation_p.D564Y|PCDH9_uc001vin.3_Missense_Mutation_p.D564Y	NM_203487	NP_982354	Q9HC56	PCDH9_HUMAN	protocadherin 9 isoform 1 precursor	564	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)|skin(1)	6		Hepatocellular(98;0.0906)|Breast(118;0.107)		GBM - Glioblastoma multiforme(99;0.00819)		TCATTCTCATCCAGAACAGTA	0.428		NA											33	155					1.75e-11	1.92e-11	1	0
RBM26	64062	broad.mit.edu	37	13	79933752	79933752	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr13:79933752G>A	uc001vkz.2	-	10	1516	c.1502C>T	c.(1501-1503)TCT>TTT	p.S501F	RBM26_uc001vky.2_Missense_Mutation_p.S496F|RBM26_uc001vla.2_Missense_Mutation_p.S496F|RBM26_uc001vkx.2_Missense_Mutation_p.S208F	NM_022118	NP_071401	Q5T8P6	RBM26_HUMAN	RNA binding motif protein 26	496					mRNA processing		nucleotide binding|protein binding|RNA binding|zinc ion binding			ovary(1)	1		Acute lymphoblastic leukemia(28;0.0279)		GBM - Glioblastoma multiforme(99;0.0188)		AGGCTCTCCAGAACCAATGGT	0.363		NA											70	202					0	0	0	0
TGDS	23483	broad.mit.edu	37	13	95233394	95233394	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr13:95233394G>C	uc001vlw.2	-	6	627	c.506C>G	c.(505-507)TCT>TGT	p.S169C	TGDS_uc001vlx.2_RNA	NM_014305	NP_055120	O95455	TGDS_HUMAN	TDP-glucose 4,6-dehydratase	169					cellular metabolic process		coenzyme binding|dTDP-glucose 4,6-dehydratase activity|protein binding				0	all_neural(89;0.0684)|Medulloblastoma(90;0.163)					AGCTGCTTTAGATGATGCATA	0.299		NA											16	77					0	0	0	0
HOMEZ	57594	broad.mit.edu	37	14	23745733	23745733	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr14:23745733C>T	uc001wja.2	-	2	852	c.704G>A	c.(703-705)AGG>AAG	p.R235K	HOMEZ_uc001wjb.2_Missense_Mutation_p.R237K	NM_020834	NP_065885	Q8IX15	HOMEZ_HUMAN	homeodomain leucine zipper protein	235						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0	all_cancers(95;5.54e-06)			GBM - Glioblastoma multiforme(265;0.00643)		GTTGGGACCCCTGCCTGCCTG	0.542		NA											37	105					0	0	0	0
SLC22A17	51310	broad.mit.edu	37	14	23816792	23816792	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr14:23816792G>A	uc001wjl.2	-	7	1149	c.1093C>T	c.(1093-1095)CGG>TGG	p.R365W	SLC22A17_uc010akk.2_Missense_Mutation_p.R147W|SLC22A17_uc001wjn.2_RNA|SLC22A17_uc001wjm.2_Missense_Mutation_p.R365W	NM_020372	NP_065105	Q8WUG5	S22AH_HUMAN	solute carrier family 22, member 17 isoform a	365					siderophore transport	integral to organelle membrane|integral to plasma membrane|vacuolar membrane	transmembrane receptor activity|transmembrane transporter activity				0	all_cancers(95;7.12e-06)			GBM - Glioblastoma multiforme(265;0.00643)		AGGATGCCCCGGCGGCCAAAT	0.632		NA											24	62					0	0	0	0
CLMN	79789	broad.mit.edu	37	14	95670229	95670229	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr14:95670229G>A	uc001yef.2	-	9	1573	c.1457C>T	c.(1456-1458)TCT>TTT	p.S486F		NM_024734	NP_079010	Q96JQ2	CLMN_HUMAN	calmin	486						integral to membrane	actin binding				0				Epithelial(152;0.193)		GACCTTGTCAGAGGAGGATTC	0.468		NA											25	50					0	0	0	0
C14orf49	161176	broad.mit.edu	37	14	95906119	95906119	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr14:95906119C>A	uc001yei.3	-	12	2091	c.2076G>T	c.(2074-2076)AGG>AGT	p.R692S	C14orf49_uc010avi.2_Missense_Mutation_p.R692S	NM_152592	NP_689805	Q6ZMZ3	SYNE3_HUMAN	nesprin-3	692	Spectrin 2.|Cytoplasmic (Potential).				cytoskeletal anchoring at nuclear membrane	integral to membrane|nuclear outer membrane|SUN-KASH complex	actin binding			central_nervous_system(1)	1		all_cancers(154;0.0937)		COAD - Colon adenocarcinoma(157;0.245)		CTGCCACCAGCCTCTAAAGGA	0.607		NA											24	63					3.01e-09	3.28e-09	1	0
PACS2	23241	broad.mit.edu	37	14	105850745	105850745	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr14:105850745C>G	uc001yqt.2	+	17	1999	c.1824C>G	c.(1822-1824)TTC>TTG	p.F608L	PACS2_uc001yqs.2_Missense_Mutation_p.F533L|PACS2_uc001yqv.2_Missense_Mutation_p.F612L|PACS2_uc001yqu.2_Missense_Mutation_p.F612L	NM_015197	NP_056012	Q86VP3	PACS2_HUMAN	phosphofurin acidic cluster sorting protein 2	608					apoptosis|interspecies interaction between organisms	endoplasmic reticulum lumen|mitochondrion				pancreas(1)	1		all_cancers(154;0.0351)|all_epithelial(191;0.153)|Melanoma(154;0.155)	OV - Ovarian serous cystadenocarcinoma(23;0.0145)|Epithelial(46;0.036)	Epithelial(152;0.138)		ACAACAACTTCTTCCAGGACC	0.677		NA											12	35					0	0	0	0
RASL12	51285	broad.mit.edu	37	15	65357567	65357567	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr15:65357567C>T	uc002aoi.1	-	2	363	c.148G>A	c.(148-150)GAC>AAC	p.D50N	RASL12_uc002aoj.1_Intron|RASL12_uc010uir.1_Missense_Mutation_p.D39N	NM_016563	NP_057647	Q9NYN1	RASLC_HUMAN	RAS-like, family 12 protein	50					small GTPase mediated signal transduction	membrane	GTP binding|GTPase activity			skin(1)	1						AAGTTGGGGTCATATTCACTG	0.572		NA											8	20					0	0	0	0
WHAMM	123720	broad.mit.edu	37	15	83495204	83495204	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr15:83495204G>A	uc002bje.2	+	7	2007	c.1501G>A	c.(1501-1503)GAA>AAA	p.E501K		NM_001080435	NP_001073904	Q8TF30	WHAMM_HUMAN	WAS protein homolog associated with actin, golgi	501						cytoplasmic vesicle membrane|ER-Golgi intermediate compartment|Golgi apparatus	actin binding				0						GCAACAGGCTGAAGAAAGCAT	0.408		NA											37	133					0	0	0	0
ZNF592	9640	broad.mit.edu	37	15	85341666	85341666	+	Silent	SNP	C	C	G			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr15:85341666C>G	uc002bld.2	+	7	3033	c.2697C>G	c.(2695-2697)CTC>CTG	p.L899L	ZNF592_uc010upb.1_RNA	NM_014630	NP_055445	Q92610	ZN592_HUMAN	zinc finger protein 592	899	C2H2-type 8.				cell death|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(4)|skin(2)	6			BRCA - Breast invasive adenocarcinoma(143;0.0587)			AGTGCCCACTCTTGTTCGTGC	0.567		NA											29	60					0	0	0	0
AGBL1	123624	broad.mit.edu	37	15	87097594	87097594	+	Silent	SNP	T	T	C			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr15:87097594T>C	uc002blz.1	+	20	2762	c.2682T>C	c.(2680-2682)ACT>ACC	p.T894T		NM_152336	NP_689549	Q96MI9	CBPC4_HUMAN	ATP/GTP binding protein-like 1	894					C-terminal protein deglutamylation|protein side chain deglutamylation|proteolysis	cytosol	metallocarboxypeptidase activity|tubulin binding|zinc ion binding				0						TACTGTAGACTCTTCCCAAAA	0.398		NA											4	7					0	0	0	0
WDR90	197335	broad.mit.edu	37	16	711778	711778	+	Silent	SNP	C	C	T			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr16:711778C>T	uc002cii.1	+	31	3909	c.3855C>T	c.(3853-3855)ATC>ATT	p.I1285I	WDR90_uc002cij.1_Intron|WDR90_uc002cik.1_Silent_p.I812I|WDR90_uc002cil.1_RNA|WDR90_uc002cim.1_Silent_p.I459I|WDR90_uc002cin.1_5'UTR	NM_145294	NP_660337	Q96KV7	WDR90_HUMAN	WD repeat domain 90	1285	WD 14.									ovary(1)	1		Hepatocellular(780;0.0218)				GGGCAGACATCAGCCTTCAGG	0.647		NA											32	101					0	0	0	0
WDR90	197335	broad.mit.edu	37	16	716485	716485	+	Silent	SNP	C	C	T			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr16:716485C>T	uc002cii.1	+	38	4825	c.4771C>T	c.(4771-4773)CTA>TTA	p.L1591L	WDR90_uc002cij.1_Intron|WDR90_uc002cil.1_RNA|WDR90_uc002cin.1_Silent_p.L206L|WDR90_uc010uul.1_Intron|WDR90_uc002cio.1_Silent_p.L190L|WDR90_uc010bqx.1_Intron|RHOT2_uc010uum.1_5'Flank|RHOT2_uc002cip.2_5'Flank|RHOT2_uc002ciq.2_5'Flank	NM_145294	NP_660337	Q96KV7	WDR90_HUMAN	WD repeat domain 90	1591	WD 20.									ovary(1)	1		Hepatocellular(780;0.0218)				GGGCACAGACCTATGGCTGGC	0.632		NA											13	36					0	0	0	0
GLYR1	84656	broad.mit.edu	37	16	4863755	4863755	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr16:4863755C>T	uc002cxx.3	-	12	1139	c.1102G>A	c.(1102-1104)GTC>ATC	p.V368I	GLYR1_uc002cxy.2_RNA|GLYR1_uc002cxz.1_Missense_Mutation_p.V282I|GLYR1_uc002cya.2_Missense_Mutation_p.V362I|GLYR1_uc010uxv.1_Missense_Mutation_p.V287I	NM_032569	NP_115958	Q49A26	GLYR1_HUMAN	cytokine-like nuclear factor n-pac	368					pentose-phosphate shunt	nucleus	coenzyme binding|DNA binding|methylated histone residue binding|phosphogluconate dehydrogenase (decarboxylating) activity				0						AGCTCAGTGACGGTGTCAGCG	0.592		NA											6	29					0	0	0	0
TMC7	79905	broad.mit.edu	37	16	19063127	19063127	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr16:19063127C>G	uc002dfq.2	+	13	1990	c.1860C>G	c.(1858-1860)ATC>ATG	p.I620M	TMC7_uc002dfp.2_Missense_Mutation_p.I620M|TMC7_uc010vap.1_Missense_Mutation_p.I510M	NM_024847	NP_079123	Q7Z402	TMC7_HUMAN	transmembrane channel-like 7 isoform a	620	Helical; (Potential).					integral to membrane				skin(2)|ovary(1)	3						CTCTGACAATCAGCATATCAC	0.413		NA											70	316					0	0	0	0
SEPHS2	22928	broad.mit.edu	37	16	30456439	30456439	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr16:30456439C>T	uc010ves.1	-	2	786	c.610G>A	c.(610-612)GAG>AAG	p.E204K	SEPHS2_uc002dyh.1_Missense_Mutation_p.E147K|SEPHS2_uc010vet.1_Missense_Mutation_p.E86K	NM_012248	NP_036380	Q99611	SPS2_HUMAN	selenophosphate synthetase 2	204					selenocysteine biosynthetic process		ATP binding|selenide, water dikinase activity			breast(2)	2						CCTCCTTCCTCAGCCGCATCC	0.517		NA											34	106					0	0	0	0
SETD1A	9739	broad.mit.edu	37	16	30976423	30976423	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr16:30976423G>A	uc002ead.1	+	7	2046	c.1360G>A	c.(1360-1362)GAA>AAA	p.E454K		NM_014712	NP_055527	O15047	SET1A_HUMAN	SET domain containing 1A	454	Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nuclear speck|Set1C/COMPASS complex	histone-lysine N-methyltransferase activity|nucleotide binding|protein binding|RNA binding			ovary(2)|skin(1)	3						CCCTGAGAGAGAAGAAGTTCG	0.697		NA											11	41					0	0	0	0
RPGRIP1L	23322	broad.mit.edu	37	16	53730193	53730193	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr16:53730193G>A	uc002ehp.2	-	3	164	c.100C>T	c.(100-102)CGG>TGG	p.R34W	RPGRIP1L_uc002eho.3_Missense_Mutation_p.R34W|RPGRIP1L_uc010vgy.1_Missense_Mutation_p.R34W|RPGRIP1L_uc010cbx.2_Missense_Mutation_p.R34W|RPGRIP1L_uc010vgz.1_Missense_Mutation_p.R34W|RPGRIP1L_uc002ehq.1_Missense_Mutation_p.R34W|RPGRIP1L_uc010cby.1_Missense_Mutation_p.R34W	NM_015272	NP_056087	Q68CZ1	FTM_HUMAN	RPGRIP1-like isoform a	34					negative regulation of G-protein coupled receptor protein signaling pathway	cell-cell junction|centrosome|cilium axoneme|microtubule basal body	thromboxane A2 receptor binding			ovary(1)	1		all_cancers(37;0.0973)				TTCATTGTCCGTGTTGTTGAA	0.373		NA											65	230					0	0	0	0
CNOT1	23019	broad.mit.edu	37	16	58608533	58608533	+	Silent	SNP	G	G	C			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr16:58608533G>C	uc002env.2	-	16	2252	c.1959C>G	c.(1957-1959)GCC>GCG	p.A653A	CNOT1_uc002enw.2_RNA|CNOT1_uc002enu.3_Silent_p.A653A|CNOT1_uc002enx.2_Silent_p.A653A|CNOT1_uc002enz.1_Silent_p.A82A	NM_016284	NP_057368	A5YKK6	CNOT1_HUMAN	CCR4-NOT transcription complex, subunit 1	653					nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol				ovary(4)|central_nervous_system(2)	6				Kidney(780;0.0722)|OV - Ovarian serous cystadenocarcinoma(108;0.173)|Epithelial(162;0.239)		CTTGCAGACAGGCCAACATTG	0.423		NA											32	105					0	0	0	0
FUK	197258	broad.mit.edu	37	16	70513582	70513582	+	Silent	SNP	G	G	A			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr16:70513582G>A	uc002eyy.2	+	24	3312	c.3254G>A	c.(3253-3255)TGA>TAA	p.*1085*	FUK_uc010cft.2_Silent_p.*1091*|FUK_uc002eyz.2_Silent_p.*576*	NM_145059	NP_659496	Q8N0W3	FUK_HUMAN	fucokinase	1085						cytoplasm	ATP binding|fucokinase activity			ovary(1)	1		Ovarian(137;0.0694)				CCTTTCCCATGAAGCTGGCTT	0.592		NA											13	45					0	0	0	0
AMAC1L3	643664	broad.mit.edu	37	17	7386198	7386198	+	Missense_Mutation	SNP	T	T	A			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr17:7386198T>A	uc010cmj.1	+	2	1010	c.895T>A	c.(895-897)TAT>AAT	p.Y299N	ZBTB4_uc002ghd.3_Intron|POLR2A_uc002ghe.2_5'Flank|POLR2A_uc002ghf.3_5'Flank	NM_001102614	NP_001096084	P0C7Q6	AMCL3_HUMAN	acyl-malonyl condensing enzyme 1-like 3	299	DUF6 2.|Helical; (Potential).					integral to membrane					0		Prostate(122;0.173)				ACTGCAGTATTATATGCTCCA	0.577		NA											55	170					0	0	0	0
TP53	7157	broad.mit.edu	37	17	7577094	7577094	+	Missense_Mutation	SNP	G	G	A	rs28934574		TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr17:7577094G>A	uc002gim.2	-	8	1038	c.844C>T	c.(844-846)CGG>TGG	p.R282W	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Missense_Mutation_p.R282W|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.R150W|TP53_uc010cng.1_Missense_Mutation_p.R150W|TP53_uc002gii.1_Missense_Mutation_p.R150W|TP53_uc010cnh.1_Missense_Mutation_p.R282W|TP53_uc010cni.1_Missense_Mutation_p.R282W|TP53_uc002gij.2_Missense_Mutation_p.R282W	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	282	|Interaction with E4F1.|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		R -> G (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> L (in sporadic cancers; somatic mutation).|R -> P (in sporadic cancers; somatic mutation).|DR -> EW (in sporadic cancers; somatic mutation).|R -> Q (in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> H (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R282W(367)|p.R282G(27)|p.R282Q(20)|p.R282P(14)|p.R282R(8)|p.0?(7)|p.R282L(3)|p.D281fs*63(2)|p.?(2)|p.R282fs*24(2)|p.D281_R282>EW(2)|p.A276_R283delACPGRDRR(1)|p.R280fs*62(1)|p.R282_E287delRRTEEE(1)|p.G279fs*59(1)|p.S269fs*21(1)|p.C275_R283delCACPGRDRR(1)|p.D281_R282insXX(1)|p.L265_K305del41(1)|p.R282H(1)|p.R283_T284>T(1)|p.V272_K292del21(1)|p.R282fs*63(1)|p.C275fs*20(1)|p.D281_R282delDR(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		TCTGTGCGCCGGTCTCTCCCA	0.557		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			19	53					0	0	0	0
TP53	7157	broad.mit.edu	37	17	7578406	7578406	+	Missense_Mutation	SNP	C	C	T	rs28934578		TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr17:7578406C>T	uc002gim.2	-	5	718	c.524G>A	c.(523-525)CGC>CAC	p.R175H	TP53_uc002gig.1_Missense_Mutation_p.R175H|TP53_uc002gih.2_Missense_Mutation_p.R175H|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.R43H|TP53_uc010cng.1_Missense_Mutation_p.R43H|TP53_uc002gii.1_Missense_Mutation_p.R43H|TP53_uc010cnh.1_Missense_Mutation_p.R175H|TP53_uc010cni.1_Missense_Mutation_p.R175H|TP53_uc002gij.2_Missense_Mutation_p.R175H|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.R82H|TP53_uc002gio.2_Missense_Mutation_p.R43H|TP53_uc010vug.1_Missense_Mutation_p.R136H	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	175	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		R -> L (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> Q (in a sporadic cancer; somatic mutation).|R -> P (in sporadic cancers; somatic mutation).|R -> G (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> C (in sporadic cancers; somatic mutation).|R -> S (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R175H(729)|p.R175L(19)|p.R175C(12)|p.R175G(11)|p.0?(7)|p.R175P(5)|p.R175S(5)|p.R43H(5)|p.R82H(5)|p.R175R(4)|p.R174fs*24(3)|p.R175_E180delRCPHHE(3)|p.R175fs*5(2)|p.V173fs*59(2)|p.R174fs*1(2)|p.V157_C176del20(1)|p.K164_P219del(1)|p.V173fs*69(1)|p.E171fs*61(1)|p.V173fs*23(1)|p.R174_H178>S(1)|p.V172_E180delVVRRCPHHE(1)|p.R174_H179delRRCPHH(1)|p.E171fs*1(1)|p.R175_H178>X(1)|p.R175fs*6(1)|p.R42fs*24(1)|p.R174_C176delRRC(1)|p.H168fs*69(1)|p.R175fs*72(1)|p.R174fs*70(1)|p.E171_H179delEVVRRCPHH(1)|p.R81fs*24(1)|p.R174_E180>K(1)|p.R174fs*3(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GTGGGGGCAGCGCCTCACAAC	0.652	R175H(KMS26_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R175H(HCC1395_BREAST)|R175H(KLE_ENDOMETRIUM)|R175H(NCIH196_LUNG)|R175H(AU565_BREAST)|R175H(TYKNU_OVARY)|R175H(DETROIT562_UPPER_AERODIGESTIVE_TRACT)|R175H(SKUT1_SOFT_TISSUE)|R175H(CAL33_UPPER_AERODIGESTIVE_TRACT)|R175H(LS123_LARGE_INTESTINE)|R175H(SKBR3_BREAST)|R175H(RKN_OVARY)|R175H(HUCCT1_BILIARY_TRACT)	111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			25	71					0	0	0	0
ALOX12B	242	broad.mit.edu	37	17	7983140	7983140	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr17:7983140C>T	uc002gjy.1	-	7	1135	c.874G>A	c.(874-876)GAC>AAC	p.D292N	uc010cnq.1_RNA	NM_001139	NP_001130	O75342	LX12B_HUMAN	arachidonate 12-lipoxygenase, 12R type	292	Lipoxygenase.				epidermis development|leukotriene biosynthetic process		arachidonate 12-lipoxygenase activity|iron ion binding|lipoxygenase activity				0						GCCACCATGTCGTCTGTGACG	0.572		NA								Multiple Myeloma(8;0.094)			13	35					0	0	0	0
ALOX12B	242	broad.mit.edu	37	17	7983186	7983186	+	Silent	SNP	C	C	G			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr17:7983186C>G	uc002gjy.1	-	7	1089	c.828G>C	c.(826-828)CTG>CTC	p.L276L	uc010cnq.1_RNA	NM_001139	NP_001130	O75342	LX12B_HUMAN	arachidonate 12-lipoxygenase, 12R type	276	Lipoxygenase.				epidermis development|leukotriene biosynthetic process		arachidonate 12-lipoxygenase activity|iron ion binding|lipoxygenase activity				0						AGCGGCGGATCAGGCCGGGGT	0.652		NA								Multiple Myeloma(8;0.094)			7	35					0	0	0	0
DNAH9	1770	broad.mit.edu	37	17	11738200	11738200	+	Silent	SNP	C	C	G			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr17:11738200C>G	uc002gne.2	+	49	9560	c.9492C>G	c.(9490-9492)CTC>CTG	p.L3164L	DNAH9_uc010coo.2_Silent_p.L2458L	NM_001372	NP_001363	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9 isoform 2	3164	Stalk (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			skin(10)|ovary(4)|breast(3)|central_nervous_system(2)|pancreas(1)	20		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		AGGCAGCTCTCAACACCCTGA	0.572		NA											4	31					0	0	0	0
CCDC55	84081	broad.mit.edu	37	17	28512309	28512309	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr17:28512309G>A	uc002heu.2	+	7	1322	c.1294G>A	c.(1294-1296)GAT>AAT	p.D432N	CCDC55_uc002hev.2_Missense_Mutation_p.D378N|CCDC55_uc010wbl.1_Missense_Mutation_p.D378N|CCDC55_uc010wbm.1_Missense_Mutation_p.D378N|CCDC55_uc002hex.2_Missense_Mutation_p.D378N	NM_032141	NP_115517	Q9H0G5	NSRP1_HUMAN	coiled-coil domain containing 55 isoform 1	432					developmental process|nucleocytoplasmic transport|regulation of alternative nuclear mRNA splicing, via spliceosome	nuclear speck|ribonucleoprotein complex	mRNA binding|protein binding				0						tgaaaataatgataaatacag	0.164		NA											10	34					0	0	0	0
NAGLU	4669	broad.mit.edu	37	17	40689478	40689478	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr17:40689478G>A	uc002hzv.2	+	2	786	c.446G>A	c.(445-447)CGC>CAC	p.R149H		NM_000263	NP_000254	P54802	ANAG_HUMAN	alpha-N-acetylglucosaminidase precursor	149						lysosome	alpha-N-acetylglucosaminidase activity				0		all_cancers(22;1.58e-05)|Breast(137;0.000153)|all_epithelial(22;0.000344)		BRCA - Breast invasive adenocarcinoma(366;0.13)	N-Acetyl-D-glucosamine(DB00141)	GACTGGGCCCGCTGGGAGCGA	0.627		NA											4	133					0	0	0	0
C17orf57	124989	broad.mit.edu	37	17	45422422	45422422	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr17:45422422G>A	uc002iln.2	+	8	886	c.475G>A	c.(475-477)GAT>AAT	p.D159N	C17orf57_uc002ilm.2_Missense_Mutation_p.D159N|C17orf57_uc002ill.1_Missense_Mutation_p.D11N|C17orf57_uc010daz.1_Missense_Mutation_p.D159N	NM_152347	NP_689560	Q8IY85	CQ057_HUMAN	hypothetical protein LOC124989	159							calcium ion binding			breast(1)|central_nervous_system(1)|skin(1)	3						GACATTATATGATGAAGTAAC	0.313		NA											48	175					0	0	0	0
COX11	1353	broad.mit.edu	37	17	53040725	53040725	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr17:53040725C>G	uc010wng.1	-	3	647	c.590G>C	c.(589-591)GGA>GCA	p.G197A	COX11_uc010wne.1_RNA|COX11_uc010wnf.1_RNA|COX11_uc002iue.2_RNA|COX11_uc010wnh.1_Missense_Mutation_p.G197A	NM_004375	NP_004366	Q9Y6N1	COX11_HUMAN	COX11 homolog, cytochrome c oxidase assembly	197	Mitochondrial intermembrane (Potential).|Mitochondrial matrix (Potential).				respiratory chain complex IV assembly|respiratory gaseous exchange	integral to membrane|mitochondrial inner membrane	copper ion binding|cytochrome-c oxidase activity|electron carrier activity			ovary(1)	1						TGTAGAAATTCCAATTACTGG	0.323		NA											26	94					0	0	0	0
KCNJ2	3759	broad.mit.edu	37	17	68171901	68171901	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr17:68171901G>A	uc010dfg.2	+	2	1122	c.721G>A	c.(721-723)GAG>AAG	p.E241K	KCNJ2_uc002jir.2_Missense_Mutation_p.E241K	NM_000891	NP_000882	P63252	IRK2_HUMAN	potassium inwardly-rectifying channel J2	241	Cytoplasmic (By similarity).				synaptic transmission	integral to plasma membrane	inward rectifier potassium channel activity|protein binding				0	Breast(10;1.64e-08)					TTCTGAAGGGGAGTATATCCC	0.448		NA											33	87					0	0	0	0
EXOC7	23265	broad.mit.edu	37	17	74085376	74085376	+	Silent	SNP	C	C	T			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr17:74085376C>T	uc002jqs.2	-	9	1175	c.1080G>A	c.(1078-1080)GAG>GAA	p.E360E	EXOC7_uc010dgv.1_Silent_p.E256E|EXOC7_uc002jqq.2_Silent_p.E309E|EXOC7_uc010wsw.1_Silent_p.E332E|EXOC7_uc010wsx.1_Silent_p.E301E|EXOC7_uc002jqr.2_Silent_p.E278E|EXOC7_uc010wsv.1_Silent_p.E268E	NM_001145297	NP_001138769	Q9UPT5	EXOC7_HUMAN	exocyst complex component 7 isoform 4	360					exocytosis|protein transport	centriolar satellite|cytosol|exocyst|plasma membrane	protein binding				0			LUSC - Lung squamous cell carcinoma(166;0.187)			AGGCATCGGTCTCCACGTCCA	0.637		NA											18	45					0	0	0	0
RPTOR	57521	broad.mit.edu	37	17	78681774	78681774	+	Missense_Mutation	SNP	A	A	G			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr17:78681774A>G	uc002jyt.1	+	4	1287	c.482A>G	c.(481-483)AAC>AGC	p.N161S	RPTOR_uc002jys.2_Missense_Mutation_p.N161S|RPTOR_uc010wuf.1_5'UTR|RPTOR_uc010wug.1_Missense_Mutation_p.N161S	NM_020761	NP_065812	Q8N122	RPTOR_HUMAN	raptor isoform 1	161					cell cycle arrest|cell growth|cellular response to amino acid stimulus|cellular response to nutrient levels|insulin receptor signaling pathway|positive regulation of protein serine/threonine kinase activity|positive regulation of TOR signaling cascade|TOR signaling cascade	cytosol|lysosome|TORC1 complex	protein complex binding			lung(4)|urinary_tract(1)|ovary(1)	6						CCCACAGTCAACGGGGAGGTC	0.592		NA											11	28					0	0	0	0
FAM59A	64762	broad.mit.edu	37	18	29867529	29867529	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr18:29867529C>A	uc002kxl.2	-	4	1087	c.1031G>T	c.(1030-1032)CGT>CTT	p.R344L	FAM59A_uc002kxk.1_Missense_Mutation_p.R344L	NM_022751	NP_073588	Q9H706	FA59A_HUMAN	family with sequence similarity 59, member A	344										ovary(1)|skin(1)	2						TTTCACATCACGGACAGCCCG	0.562		NA											33	67					4.34e-12	4.79e-12	1	0
MYO5B	4645	broad.mit.edu	37	18	47563335	47563335	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr18:47563335C>T	uc002leb.2	-	4	628	c.340G>A	c.(340-342)GAA>AAA	p.E114K	MYO5B_uc002lec.1_Missense_Mutation_p.E113K	NM_001080467	NP_001073936	Q9ULV0	MYO5B_HUMAN	myosin VB	114	Myosin head-like.				protein transport	myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			ovary(2)|skin(2)|central_nervous_system(1)	5				READ - Rectum adenocarcinoma(32;0.103)		GGCAACTGTTCATAAGGATTA	0.468		NA											17	40					0	0	0	0
POLRMT	5442	broad.mit.edu	37	19	618526	618526	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr19:618526G>T	uc002lpf.1	-	17	3440	c.3384C>A	c.(3382-3384)GAC>GAA	p.D1128E		NM_005035	NP_005026	O00411	RPOM_HUMAN	mitochondrial DNA-directed RNA polymerase	1128	Mediates interaction with TEFM.				transcription initiation from mitochondrial promoter	mitochondrial nucleoid	DNA binding|DNA-directed RNA polymerase activity|protein binding			ovary(1)|pancreas(1)	2		all_epithelial(18;2.78e-22)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;3.55e-06)|all_lung(49;5.41e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TGTGGGAGGAGTCCAGCGAGT	0.662		NA											11	30					6.4e-05	6.78e-05	1	0
TUBB4	10382	broad.mit.edu	37	19	6501305	6501305	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr19:6501305G>C	uc002mfg.1	-	3	377	c.270C>G	c.(268-270)TTC>TTG	p.F90L	TUBB4_uc002mff.1_Missense_Mutation_p.F18L	NM_006087	NP_006078	P04350	TBB4_HUMAN	tubulin, beta 4	90					'de novo' posttranslational protein folding|G2/M transition of mitotic cell cycle|microtubule-based movement|protein polymerization	cytosol|microtubule	GTP binding|GTPase activity|protein binding|structural molecule activity			ovary(2)	2		Hepatocellular(1079;0.00213)|Renal(1328;0.0183)		Lung(535;3.23e-05)|STAD - Stomach adenocarcinoma(1328;8.24e-05)|GBM - Glioblastoma multiforme(1328;0.00839)|READ - Rectum adenocarcinoma(264;0.155)		CACCAAACACGAAGTTGTCCG	0.592		NA											11	57					0	0	0	0
MUC16	94025	broad.mit.edu	37	19	9056712	9056712	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr19:9056712G>A	uc002mkp.2	-	3	30938	c.30734C>T	c.(30733-30735)TCC>TTC	p.S10245F		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	10247	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						TTCTGGGAAGGAGGTTATCCC	0.463		NA											24	62					0	0	0	0
CCDC151	115948	broad.mit.edu	37	19	11545748	11545748	+	Silent	SNP	C	C	T			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr19:11545748C>T	uc002mrs.2	-	1	233	c.90G>A	c.(88-90)AGG>AGA	p.R30R	CCDC151_uc010dxz.2_Silent_p.R30R|PRKCSH_uc002mrt.2_5'Flank|PRKCSH_uc002mru.2_5'Flank|PRKCSH_uc010xlz.1_5'Flank|PRKCSH_uc010dya.2_5'Flank|PRKCSH_uc002mrv.1_5'Flank|PRKCSH_uc010dyb.2_5'Flank	NM_145045	NP_659482	A5D8V7	CC151_HUMAN	coiled-coil domain containing 151	30										ovary(1)	1						CCGAAGCCTCCCTGCCCTTGA	0.667		NA									OREG0025257	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	25	97					0	0	0	0
SFRS16	11129	broad.mit.edu	37	19	45561076	45561076	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr19:45561076C>T	uc002pak.2	+	7	631	c.533C>T	c.(532-534)GCG>GTG	p.A178V	SFRS16_uc002pal.2_RNA|SFRS16_uc010xxh.1_Missense_Mutation_p.A116V|SFRS16_uc002pam.2_Missense_Mutation_p.A178V|SFRS16_uc002pan.1_RNA	NM_007056	NP_008987	Q8N2M8	CLASR_HUMAN	splicing factor, arginine/serine-rich 16	178					mRNA processing|RNA splicing	nucleus					0		Ovarian(192;0.0728)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.0102)		GTAGAGAAGGCGGCAGAAAAG	0.612		NA											27	131					0	0	0	0
SLC8A2	6543	broad.mit.edu	37	19	47935484	47935484	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr19:47935484C>T	uc002pgx.2	-	9	2607	c.2329G>A	c.(2329-2331)GTT>ATT	p.V777I	SLC8A2_uc010xyq.1_Missense_Mutation_p.V533I|SLC8A2_uc010xyr.1_Missense_Mutation_p.V240I|SLC8A2_uc010ele.2_Missense_Mutation_p.V777I	NM_015063	NP_055878	Q9UPR5	NAC2_HUMAN	solute carrier family 8 member 2 precursor	777	Helical; (Potential).				cell communication|platelet activation	integral to membrane|plasma membrane	calcium:sodium antiporter activity|calmodulin binding			skin(3)|ovary(1)	4		all_cancers(25;3.05e-07)|all_lung(116;4.19e-06)|Lung NSC(112;7.16e-06)|all_epithelial(76;7.65e-06)|all_neural(266;0.0652)|Ovarian(192;0.086)|Breast(70;0.173)		OV - Ovarian serous cystadenocarcinoma(262;0.000501)|all cancers(93;0.00058)|Epithelial(262;0.0181)|GBM - Glioblastoma multiforme(486;0.0457)		TTGAGGCCAACGGTGCAGCCG	0.607		NA											14	89					0	0	0	0
CCDC114	93233	broad.mit.edu	37	19	48801464	48801464	+	Silent	SNP	G	G	T			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr19:48801464G>T	uc002pir.2	-	11	1946	c.1263C>A	c.(1261-1263)CTC>CTA	p.L421L	CCDC114_uc002piq.2_Silent_p.L230L|CCDC114_uc002pio.2_Silent_p.L458L|CCDC114_uc002pis.1_Silent_p.L101L|CCDC114_uc002pit.1_Silent_p.L458L	NM_144577	NP_653178	Q96M63	CC114_HUMAN	coiled-coil domain containing 114 isoform 2	421										ovary(1)	1		all_epithelial(76;9.64e-05)|all_lung(116;0.000147)|Lung NSC(112;0.000251)|Prostate(7;0.0187)|all_neural(266;0.0228)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000134)|all cancers(93;0.000162)|Epithelial(262;0.0134)|GBM - Glioblastoma multiforme(486;0.0143)		GCACTGTCAGGAGCTCCACCA	0.652		NA											13	63					5.51e-06	5.84e-06	1	0
HAS1	3036	broad.mit.edu	37	19	52216936	52216936	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr19:52216936C>T	uc002pxo.1	-	5	1516	c.1481G>A	c.(1480-1482)CGG>CAG	p.R494Q	HAS1_uc010epc.1_Missense_Mutation_p.R94Q|HAS1_uc010epd.1_3'UTR|HAS1_uc002pxn.1_Missense_Mutation_p.R501Q|HAS1_uc002pxp.1_Missense_Mutation_p.R493Q	NM_001523	NP_001514	Q92839	HAS1_HUMAN	hyaluronan synthase 1	494	Extracellular (Potential).				cell adhesion	integral to plasma membrane	hyaluronan synthase activity|protein binding			ovary(1)|pancreas(1)	2		all_neural(266;0.0189)|Medulloblastoma(540;0.146)		GBM - Glioblastoma multiforme(134;0.00102)|OV - Ovarian serous cystadenocarcinoma(262;0.0177)		GGCCAGCTTCCGCCGGCCCGA	0.687		NA											5	4					0	0	0	0
PPP2R1A	5518	broad.mit.edu	37	19	52709301	52709301	+	Silent	SNP	C	C	T			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr19:52709301C>T	uc002pyp.2	+	3	414	c.255C>T	c.(253-255)TAC>TAT	p.Y85Y	PPP2R1A_uc010ydk.1_Intron|PPP2R1A_uc010epm.1_Silent_p.Y125Y|PPP2R1A_uc002pyq.2_Translation_Start_Site	NM_014225	NP_055040	P30153	2AAA_HUMAN	alpha isoform of regulatory subunit A, protein	85	PP2A subunit B binding.|SV40 small T antigen binding.|HEAT 3.|Polyoma small and medium T antigens Binding.				ceramide metabolic process|chromosome segregation|G2/M transition of mitotic cell cycle|inactivation of MAPK activity|induction of apoptosis|negative regulation of cell growth|negative regulation of tyrosine phosphorylation of Stat3 protein|protein complex assembly|protein dephosphorylation|regulation of cell adhesion|regulation of cell differentiation|regulation of DNA replication|regulation of transcription, DNA-dependent|regulation of Wnt receptor signaling pathway|response to organic substance|RNA splicing|second-messenger-mediated signaling	chromosome, centromeric region|cytosol|membrane|microtubule cytoskeleton|mitochondrion|nucleus|protein phosphatase type 2A complex|soluble fraction	antigen binding|protein heterodimerization activity|protein phosphatase type 2A regulator activity			endometrium(31)|ovary(28)|lung(2)|breast(2)|skin(1)|kidney(1)|pancreas(1)	66				GBM - Glioblastoma multiforme(134;0.00456)|OV - Ovarian serous cystadenocarcinoma(262;0.015)		GCCCAGAGTACGTGCACTGCC	0.612		NA	Mis		clear cell ovarian carcinoma								26	118					0	0	0	0
ZNF160	90338	broad.mit.edu	37	19	53578367	53578367	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr19:53578367G>C	uc010eqk.2	-	5	501	c.85C>G	c.(85-87)CAG>GAG	p.Q29E	ZNF160_uc002qaq.3_Missense_Mutation_p.Q29E|ZNF160_uc002qar.3_Missense_Mutation_p.Q29E|ZNF160_uc002qas.3_Missense_Mutation_p.Q29E	NM_001102603	NP_001096073	Q9HCG1	ZN160_HUMAN	zinc finger protein 160	29	KRAB.				hemopoiesis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)	1				GBM - Glioblastoma multiforme(134;0.02)		AAGATCCTCTGAGCAGGGTCC	0.453		NA											68	134					0	0	0	0
FCAR	2204	broad.mit.edu	37	19	55401040	55401040	+	Silent	SNP	G	G	A			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr19:55401040G>A	uc002qhr.1	+	5	872	c.675G>A	c.(673-675)ACG>ACA	p.T225T	FCAR_uc002qhs.1_RNA|FCAR_uc002qht.1_Silent_p.T176T|FCAR_uc010esi.1_Silent_p.T102T|FCAR_uc002qhu.1_Silent_p.T129T|FCAR_uc002qhv.1_Silent_p.T203T|FCAR_uc002qhw.1_Silent_p.T213T|FCAR_uc002qhx.1_Silent_p.T117T|FCAR_uc002qhy.1_Silent_p.T191T|FCAR_uc002qhz.1_Missense_Mutation_p.A189T|FCAR_uc002qia.1_Silent_p.T116T	NM_002000	NP_001991	P24071	FCAR_HUMAN	Fc alpha receptor isoform a precursor	225	Extracellular (Potential).				immune response	extracellular region|integral to plasma membrane	IgA binding|receptor activity			ovary(1)|skin(1)	2				GBM - Glioblastoma multiforme(193;0.0443)		ATTACACGACGCAGAACTTGA	0.527		NA											123	537					0	0	0	0
TMEM150B	284417	broad.mit.edu	37	19	55824413	55824413	+	Silent	SNP	G	G	A			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr19:55824413G>A	uc010esw.1	-	8	689	c.516C>T	c.(514-516)CTC>CTT	p.L172L	TMEM150B_uc010yfu.1_Silent_p.L172L|TMEM150B_uc010yfv.1_RNA|TMEM150B_uc010yfw.1_RNA	NM_001085488	NP_001078957	A6NC51	T150B_HUMAN	transmembrane protein 150B precursor	172	Helical; (Potential).					integral to membrane					0						AGCAGGCGTGGAGGACGATCA	0.687		NA											5	15					0	0	0	0
ZIM3	114026	broad.mit.edu	37	19	57646830	57646830	+	Nonsense_Mutation	SNP	G	G	C			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr19:57646830G>C	uc002qnz.1	-	5	1261	c.875C>G	c.(874-876)TCA>TGA	p.S292*		NM_052882	NP_443114	Q96PE6	ZIM3_HUMAN	zinc finger, imprinted 3	292	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			pancreas(1)|skin(1)	2		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.243)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		AATGAGGGTTGAGTTCTGCCT	0.378		NA											118	195					0	0	0	0
VN1R1	57191	broad.mit.edu	37	19	57966870	57966870	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr19:57966870C>T	uc002qos.1	-	1	985	c.985G>A	c.(985-987)GAT>AAT	p.D329N	ZNF547_uc002qpm.3_Intron	NM_020633	NP_065684	Q9GZP7	VN1R1_HUMAN	vomeronasal 1 receptor 1	329	Cytoplasmic (Potential).				response to pheromone	integral to membrane|plasma membrane	pheromone receptor activity			ovary(1)	1		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0694)|Renal(1328;0.157)|Breast(46;0.222)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0254)|Lung(386;0.171)		ATATGAGTATCACTCATGATG	0.463		NA											30	99					0	0	0	0
NT5C1B	93034	broad.mit.edu	37	2	18745214	18745214	+	Missense_Mutation	SNP	C	C	T	rs140939592	byFrequency	TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr2:18745214C>T	uc002rcz.2	-	10	1785	c.1681G>A	c.(1681-1683)GAA>AAA	p.E561K	NT5C1B_uc002rcy.2_Missense_Mutation_p.E561K|NT5C1B_uc010exr.2_Intron|NT5C1B_uc010yju.1_Missense_Mutation_p.E501K|NT5C1B_uc002rda.2_Missense_Mutation_p.E501K|NT5C1B_uc010yjv.1_Missense_Mutation_p.E578K|NT5C1B_uc010yjw.1_Missense_Mutation_p.E544K|NT5C1B_uc010exs.2_Missense_Mutation_p.E563K	NM_001002006	NP_001002006	Q96P26	5NT1B_HUMAN	5' nucleotidase, cytosolic IB isoform 1	561					purine base metabolic process|purine nucleotide catabolic process	cytosol	5'-nucleotidase activity|magnesium ion binding|nucleotide binding			skin(2)|ovary(1)	3	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.177)	Ovarian(717;0.208)				AAAAGAGCTTCGTCTATCTCT	0.537		NA											38	118					0	0	0	0
XDH	7498	broad.mit.edu	37	2	31621533	31621533	+	Silent	SNP	G	G	A	rs118042822	by1000genomes	TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr2:31621533G>A	uc002rnv.1	-	5	418	c.339C>T	c.(337-339)TGC>TGT	p.C113C		NM_000379	NP_000370	P47989	XDH_HUMAN	xanthine dehydrogenase	113		Iron-sulfur (2Fe-2S) 2.			purine nucleotide catabolic process|xanthine catabolic process	cytosol|extracellular region|peroxisome	2 iron, 2 sulfur cluster binding|electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|molybdopterin cofactor binding|protein homodimerization activity|xanthine dehydrogenase activity|xanthine oxidase activity			skin(4)|breast(2)|ovary(1)|central_nervous_system(1)	8	Acute lymphoblastic leukemia(172;0.155)				Allopurinol(DB00437)|Carvedilol(DB01136)|Daunorubicin(DB00694)|Deferoxamine(DB00746)|Desflurane(DB01189)|Menadione(DB00170)|Mercaptopurine(DB01033)|Methotrexate(DB00563)|NADH(DB00157)|Nitrofurazone(DB00336)|Papaverine(DB01113)|Procarbazine(DB01168)|Pyrazinamide(DB00339)|Rasburicase(DB00049)|Spermine(DB00127)|Trifluoperazine(DB00831)|Vitamin E(DB00163)	TGCAGAACCCGCACTGGGAGC	0.552		NA											55	176					0	0	0	0
FAM98A	25940	broad.mit.edu	37	2	33813507	33813507	+	Silent	SNP	A	A	G			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr2:33813507A>G	uc002rpa.1	-	4	491	c.417T>C	c.(415-417)GGT>GGC	p.G139G	FAM98A_uc010yne.1_Intron|FAM98A_uc010ynd.1_5'Flank|FAM98A_uc002roz.1_Silent_p.G16G	NM_015475	NP_056290	Q8NCA5	FA98A_HUMAN	hypothetical protein LOC25940	139										ovary(1)	1	all_hematologic(175;0.115)					AGACCTCACTACCGCCTCCTT	0.413		NA											41	180					0	0	0	0
USP34	9736	broad.mit.edu	37	2	61447483	61447483	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr2:61447483C>T	uc002sbe.2	-	67	8031	c.8009G>A	c.(8008-8010)CGG>CAG	p.R2670Q		NM_014709	NP_055524	Q70CQ2	UBP34_HUMAN	ubiquitin specific protease 34	2670					positive regulation of canonical Wnt receptor signaling pathway|protein K48-linked deubiquitination|ubiquitin-dependent protein catabolic process|Wnt receptor signaling pathway		cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(8)|breast(5)|skin(3)|lung(2)|prostate(1)	19			Epithelial(17;0.229)			CAAAAGAAACCGCTCGACCCA	0.378		NA											103	383					0	0	0	0
C2orf3	6936	broad.mit.edu	37	2	75921517	75921517	+	Silent	SNP	C	C	T			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr2:75921517C>T	uc002sno.2	-	6	1000	c.870G>A	c.(868-870)CTG>CTA	p.L290L	C2orf3_uc010ffs.2_5'UTR|C2orf3_uc002snn.2_Silent_p.L121L|C2orf3_uc010fft.2_5'UTR	NM_003203	NP_003194	P16383	GCF_HUMAN	hypothetical protein LOC6936	290	Potential.				negative regulation of transcription, DNA-dependent	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(1)|central_nervous_system(1)	2						CATACTCCCTCAGGTGTGAGC	0.294		NA											51	178					0	0	0	0
RFTN2	130132	broad.mit.edu	37	2	198498526	198498526	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr2:198498526C>G	uc002uuo.3	-	4	1036	c.634G>C	c.(634-636)GAG>CAG	p.E212Q		NM_144629	NP_653230	Q52LD8	RFTN2_HUMAN	raftlin family member 2	212						plasma membrane					0						AGTTCTTCCTCAATTCCGCTT	0.403		NA											65	155					0	0	0	0
STK36	27148	broad.mit.edu	37	2	219562684	219562684	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr2:219562684C>T	uc002viu.2	+	25	3283	c.3017C>T	c.(3016-3018)GCC>GTC	p.A1006V	STK36_uc002viv.2_Missense_Mutation_p.A985V|STK36_uc002viw.2_Missense_Mutation_p.A184V|STK36_uc002vix.2_Missense_Mutation_p.A51V	NM_015690	NP_056505	Q9NRP7	STK36_HUMAN	serine/threonine kinase 36	1006					cilium assembly|positive regulation of hh target transcription factor activity|positive regulation of smoothened signaling pathway|post-embryonic development	aggresome|cytoplasm|focal adhesion|intermediate filament cytoskeleton|nucleus	ATP binding|protein serine/threonine kinase activity|transcription factor binding			ovary(4)|stomach(2)|lung(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)	11		Renal(207;0.0915)		Epithelial(149;9.65e-07)|all cancers(144;0.000174)|LUSC - Lung squamous cell carcinoma(224;0.00813)|Lung(261;0.00984)		GGTGTCTTGGCCGACCTCAGG	0.547		NA											4	172					0	0	0	0
FARP2	9855	broad.mit.edu	37	2	242312558	242312558	+	Silent	SNP	G	G	A			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr2:242312558G>A	uc002wbi.1	+	2	153	c.36G>A	c.(34-36)CAG>CAA	p.Q12Q	FARP2_uc010zoq.1_Silent_p.Q12Q|FARP2_uc010zor.1_Silent_p.Q12Q	NM_014808	NP_055623	O94887	FARP2_HUMAN	FERM, RhoGEF and pleckstrin domain protein 2	12					axon guidance|neuron remodeling|Rac protein signal transduction|regulation of Rho protein signal transduction	cytoskeleton|cytosol|extrinsic to membrane	cytoskeletal protein binding|Rho guanyl-nucleotide exchange factor activity			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3		all_cancers(19;4.88e-34)|all_epithelial(40;4.81e-14)|Breast(86;0.000141)|Renal(207;0.0143)|all_lung(227;0.0344)|Lung NSC(271;0.0886)|Ovarian(221;0.0905)|Esophageal squamous(248;0.131)|all_hematologic(139;0.182)|Melanoma(123;0.238)		Epithelial(32;1.81e-33)|all cancers(36;1.61e-30)|OV - Ovarian serous cystadenocarcinoma(60;6.83e-15)|Kidney(56;1.19e-08)|KIRC - Kidney renal clear cell carcinoma(57;8.98e-08)|BRCA - Breast invasive adenocarcinoma(100;1.49e-06)|Lung(119;0.000152)|LUSC - Lung squamous cell carcinoma(224;0.00125)|Colorectal(34;0.0199)|COAD - Colon adenocarcinoma(134;0.121)		GAGTCCTGCAGACTGCAGGGA	0.488		NA											36	79					0	0	0	0
SIRPG	55423	broad.mit.edu	37	20	1629897	1629897	+	Silent	SNP	G	G	A			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr20:1629897G>A	uc002wfm.1	-	2	296	c.231C>T	c.(229-231)ATC>ATT	p.I77I	SIRPG_uc002wfn.1_Silent_p.I77I|SIRPG_uc002wfo.1_Silent_p.I77I	NM_018556	NP_061026	Q9P1W8	SIRPG_HUMAN	signal-regulatory protein gamma isoform 1	77	Extracellular (Potential).|Ig-like V-type.				blood coagulation|cell adhesion|cell junction assembly|cell-cell signaling|intracellular signal transduction|leukocyte migration|negative regulation of cell proliferation|positive regulation of cell proliferation|positive regulation of cell-cell adhesion|positive regulation of T cell activation	integral to membrane|intracellular|plasma membrane	protein binding			ovary(1)	1						TTTGATTGTAGATTAATTCCC	0.517		NA											44	146					0	0	0	0
EPB41L1	2036	broad.mit.edu	37	20	34806864	34806864	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr20:34806864G>A	uc002xfb.2	+	18	2506	c.2335G>A	c.(2335-2337)GAA>AAA	p.E779K	EPB41L1_uc002xeu.2_Missense_Mutation_p.E677K|EPB41L1_uc010zvo.1_Missense_Mutation_p.E751K|EPB41L1_uc002xev.2_Missense_Mutation_p.E778K|EPB41L1_uc002xew.2_Missense_Mutation_p.E670K|EPB41L1_uc002xex.2_Missense_Mutation_p.E599K|EPB41L1_uc002xey.2_Missense_Mutation_p.E529K|EPB41L1_uc002xez.2_Missense_Mutation_p.E677K|EPB41L1_uc010gfq.2_Missense_Mutation_p.E877K	NM_012156	NP_036288	Q9H4G0	E41L1_HUMAN	erythrocyte membrane protein band 4.1-like 1	779	Carboxyl-terminal (CTD).				cortical actin cytoskeleton organization|synaptic transmission	cytoskeleton|cytosol|extrinsic to membrane|plasma membrane	actin binding|structural molecule activity			ovary(2)|pancreas(1)	3	Breast(12;0.0239)					GGTGGCCACGGAAATCCGTTC	0.582		NA											10	38					0	0	0	0
PTPRT	11122	broad.mit.edu	37	20	40979290	40979290	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr20:40979290G>A	uc002xkg.2	-	11	2027	c.1843C>T	c.(1843-1845)CAG>TAG	p.Q615*	PTPRT_uc010ggj.2_Nonsense_Mutation_p.Q615*	NM_007050	NP_008981	O14522	PTPRT_HUMAN	protein tyrosine phosphatase, receptor type, T	615	Extracellular (Potential).|Fibronectin type-III 4.				homophilic cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	cell surface|integral to membrane|plasma membrane	alpha-catenin binding|beta-catenin binding|cadherin binding|delta-catenin binding|gamma-catenin binding|protein tyrosine phosphatase activity|receptor activity			skin(8)|ovary(7)|lung(5)	20		Myeloproliferative disorder(115;0.00452)|Lung NSC(126;0.0573)|all_lung(126;0.0783)				CCCCGGGACTGAGCGGGTTTC	0.527		NA											30	139					0	0	0	0
C20orf111	51526	broad.mit.edu	37	20	42825779	42825779	+	Silent	SNP	C	C	T			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr20:42825779C>T	uc002xlk.2	-	4	929	c.792G>A	c.(790-792)GTG>GTA	p.V264V		NM_016470	NP_057554	Q9NX31	CT111_HUMAN	oxidative stress responsive 1	264											0		Myeloproliferative disorder(115;0.028)	COAD - Colon adenocarcinoma(18;0.00189)			CCTCAATGGTCACATCATCCA	0.488		NA											30	159					0	0	0	0
STAU1	6780	broad.mit.edu	37	20	47734390	47734390	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr20:47734390G>A	uc002xud.2	-	11	1844	c.1433C>T	c.(1432-1434)TCA>TTA	p.S478L	STAU1_uc002xua.2_Missense_Mutation_p.S397L|STAU1_uc002xub.2_Missense_Mutation_p.S403L|STAU1_uc002xuc.2_Missense_Mutation_p.S397L|STAU1_uc002xue.2_Missense_Mutation_p.S397L|STAU1_uc002xuf.2_Missense_Mutation_p.S403L|STAU1_uc002xug.2_Missense_Mutation_p.S478L	NM_017453	NP_059347	O95793	STAU1_HUMAN	staufen isoform b	478						microtubule associated complex|rough endoplasmic reticulum|stress granule	double-stranded RNA binding			ovary(4)|kidney(1)	5			BRCA - Breast invasive adenocarcinoma(12;0.000644)|Colorectal(8;0.198)			TACGTGGCCTGAAGAGATGTT	0.537		NA											24	93					0	0	0	0
PI4KA	5297	broad.mit.edu	37	22	21115663	21115663	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr22:21115663G>A	uc002zsz.3	-	23	2777	c.2546C>T	c.(2545-2547)TCA>TTA	p.S849L		NM_058004	NP_477352	P42356	PI4KA_HUMAN	phosphatidylinositol 4-kinase type 3 alpha	849					phosphatidylinositol biosynthetic process|phosphatidylinositol-mediated signaling|synaptic transmission	Golgi-associated vesicle	1-phosphatidylinositol 4-kinase activity|ATP binding|protein binding			lung(2)|upper_aerodigestive_tract(1)|salivary_gland(1)	4	all_cancers(11;7.59e-25)|all_epithelial(7;1.34e-22)|Melanoma(16;0.000465)|Ovarian(15;0.00167)|Colorectal(54;0.0332)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.000536)|Lung(15;0.0108)|Epithelial(17;0.196)			AGGATCTGTTGAACGCAGTAC	0.393		NA											23	46					0	0	0	0
CHDH	55349	broad.mit.edu	37	3	53852082	53852082	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr3:53852082G>A	uc003dgz.2	-	9	1947	c.1507C>T	c.(1507-1509)CGG>TGG	p.R503W		NM_018397	NP_060867	Q8NE62	CHDH_HUMAN	choline dehydrogenase precursor	503					alcohol metabolic process		choline dehydrogenase activity|flavin adenine dinucleotide binding			ovary(1)|central_nervous_system(1)	2		Hepatocellular(537;0.152)		BRCA - Breast invasive adenocarcinoma(193;0.000158)|KIRC - Kidney renal clear cell carcinoma(284;0.00588)|Kidney(284;0.00673)|OV - Ovarian serous cystadenocarcinoma(275;0.118)	Choline(DB00122)	GCTTTTGCCCGCACAAAGGCA	0.582		NA											4	141					0	0	0	0
TFG	10342	broad.mit.edu	37	3	100463729	100463729	+	Silent	SNP	G	G	A			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr3:100463729G>A	uc003due.2	+	7	1223	c.774G>A	c.(772-774)CCG>CCA	p.P258P	TFG_uc003duf.2_Silent_p.P258P|TFG_uc003dug.2_Silent_p.P254P|TFG_uc003duh.2_Silent_p.P254P|TFG_uc003dui.2_Silent_p.P258P	NM_006070	NP_006061	Q92734	TFG_HUMAN	TRK-fused	258					positive regulation of I-kappaB kinase/NF-kappaB cascade	cytoplasm	signal transducer activity		TFG/ALK(7)	haematopoietic_and_lymphoid_tissue(7)|lung(2)|large_intestine(1)|prostate(1)	11						CACAGCAGCCGCAGGCTCCAC	0.468		NA	T	NTRK1|ALK	papillary thyroid|ALCL|NSCLC								19	103					0	0	0	0
C3orf1	51300	broad.mit.edu	37	3	119236073	119236073	+	Silent	SNP	G	G	A			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr3:119236073G>A	uc003ecn.2	+	6	831	c.618G>A	c.(616-618)CTG>CTA	p.L206L	C3orf1_uc003eco.2_RNA|C3orf1_uc003ecp.2_RNA	NM_016589	NP_057673	Q9NPL8	TIDC1_HUMAN	hypothetical protein LOC51300	206	Helical; (Potential).					integral to membrane|mitochondrial inner membrane	protein transporter activity				0				GBM - Glioblastoma multiforme(114;0.186)		GAGGCCTGCTGATGGCATTTC	0.453		NA											29	144					0	0	0	0
CD80	941	broad.mit.edu	37	3	119248743	119248743	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr3:119248743C>T	uc003ecq.2	-	5	1137	c.742G>A	c.(742-744)GCC>ACC	p.A248T	CD80_uc010hqt.1_Intron|CD80_uc010hqu.1_Intron	NM_005191	NP_005182	P33681	CD80_HUMAN	CD80 antigen precursor	248	Helical; (Potential).				interspecies interaction between organisms|intracellular signal transduction|positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process|positive regulation of interleukin-2 biosynthetic process|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of signal transduction|positive regulation of T-helper 1 cell differentiation|positive regulation of transcription, DNA-dependent|T cell costimulation	intracellular	coreceptor activity|protein binding			upper_aerodigestive_tract(1)|ovary(1)	2					Abatacept(DB01281)	AAGGTAATGGCCCAGGATGGG	0.403		NA											20	114					0	0	0	0
CCDC48	79825	broad.mit.edu	37	3	128755858	128755858	+	Silent	SNP	G	G	A			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr3:128755858G>A	uc011bkt.1	+	6	1488	c.1488G>A	c.(1486-1488)CTG>CTA	p.L496L		NM_024768	NP_079044	Q9HA90	CCD48_HUMAN	coiled-coil domain containing 48	496	Potential.										0						ATGAGCACCTGAGGCTGGAGC	0.627		NA											20	65					0	0	0	0
AMOTL2	51421	broad.mit.edu	37	3	134086483	134086483	+	Silent	SNP	G	G	A			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr3:134086483G>A	uc003eqf.2	-	3	1188	c.1071C>T	c.(1069-1071)GCC>GCT	p.A357A	AMOTL2_uc003eqg.1_Silent_p.A299A|AMOTL2_uc003eqh.1_Silent_p.A299A|AMOTL2_uc003eqe.1_5'Flank	NM_016201	NP_057285	Q9Y2J4	AMOL2_HUMAN	angiomotin like 2	299										large_intestine(1)	1						AGGAGGCCTGGGCACTCACTG	0.667		NA											27	88					0	0	0	0
GRK7	131890	broad.mit.edu	37	3	141497261	141497261	+	Silent	SNP	C	C	T			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr3:141497261C>T	uc011bnd.1	+	1	219	c.135C>T	c.(133-135)TGC>TGT	p.C45C		NM_139209	NP_631948	Q8WTQ7	GRK7_HUMAN	G-protein-coupled receptor kinase 7 precursor	45					visual perception	membrane	ATP binding|G-protein coupled receptor kinase activity|signal transducer activity			lung(2)|stomach(1)|ovary(1)|skin(1)	5						TGCAGGGCTGCGCGGAGCTCC	0.687		NA											12	33					0	0	0	0
RAP2B	5912	broad.mit.edu	37	3	152880843	152880843	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr3:152880843G>C	uc003ezr.2	+	1	815	c.361G>C	c.(361-363)GAG>CAG	p.E121Q		NM_002886	NP_002877	P61225	RAP2B_HUMAN	RAP2B, member of RAS oncogene family precursor	121					Rap protein signal transduction|regulation of protein tyrosine kinase activity	recycling endosome membrane	GTP binding|GTPase activity			lung(2)	2			LUSC - Lung squamous cell carcinoma(72;0.0628)|Lung(72;0.11)			GGTGGACCTGGAGGGTGAGCG	0.627		NA											43	75					0	0	0	0
SLC7A14	57709	broad.mit.edu	37	3	170184960	170184960	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr3:170184960C>G	uc003fgz.2	-	8	2515	c.2199G>C	c.(2197-2199)CAG>CAC	p.Q733H	CLDN11_uc011bpt.1_Intron|uc003fha.1_5'Flank	NM_020949	NP_066000	Q8TBB6	S7A14_HUMAN	solute carrier family 7 (cationic amino acid	733						integral to membrane	amino acid transmembrane transporter activity			ovary(2)|upper_aerodigestive_tract(1)|liver(1)|central_nervous_system(1)	5	all_cancers(22;2.41e-22)|all_epithelial(15;4.2e-27)|all_lung(20;1.17e-16)|Lung NSC(18;4.91e-16)|Ovarian(172;0.000902)|Breast(254;0.137)		Lung(28;6.23e-13)|LUSC - Lung squamous cell carcinoma(14;1.48e-12)			CATCTGACATCTGTTGGTAAT	0.532		NA											48	208					0	0	0	0
EIF4G1	1981	broad.mit.edu	37	3	184043113	184043113	+	Silent	SNP	G	G	A			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr3:184043113G>A	uc003fnp.2	+	19	3111	c.2913G>A	c.(2911-2913)ACG>ACA	p.T971T	EIF4G1_uc003fno.1_Silent_p.T912T|EIF4G1_uc010hxw.1_Silent_p.T807T|EIF4G1_uc003fnt.2_Silent_p.T682T|EIF4G1_uc003fnq.2_Silent_p.T884T|EIF4G1_uc003fnr.2_Silent_p.T807T|EIF4G1_uc010hxx.2_Silent_p.T978T|EIF4G1_uc003fns.2_Silent_p.T931T|EIF4G1_uc010hxy.2_Silent_p.T978T|EIF4G1_uc003fnv.3_Silent_p.T972T|EIF4G1_uc003fnu.3_Silent_p.T971T|EIF4G1_uc003fnw.2_Silent_p.T978T|EIF4G1_uc003fnx.2_Silent_p.T776T|EIF4G1_uc003fny.3_Silent_p.T775T|SNORD66_uc003fnz.2_5'Flank	NM_198241	NP_937884	Q04637	IF4G1_HUMAN	eukaryotic translation initiation factor 4	971	eIF3/EIF4A-binding.				insulin receptor signaling pathway|interspecies interaction between organisms|nuclear-transcribed mRNA poly(A) tail shortening|regulation of translational initiation	cytosol|eukaryotic translation initiation factor 4F complex	protein binding|translation initiation factor activity			lung(2)|ovary(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	7	all_cancers(143;1.06e-10)|Ovarian(172;0.0339)		Epithelial(37;1.53e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			AAAAGAAGACGTCATCCCGCA	0.522		NA											32	162					0	0	0	0
WHSC1	7468	broad.mit.edu	37	4	1976646	1976646	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr4:1976646C>A	uc003gdz.3	+	19	3605	c.3429C>A	c.(3427-3429)AGC>AGA	p.S1143R	WHSC1_uc003geb.3_Missense_Mutation_p.S1143R|WHSC1_uc003gec.3_Missense_Mutation_p.S1143R|WHSC1_uc003ged.3_Missense_Mutation_p.S1143R|WHSC1_uc003gee.3_RNA|WHSC1_uc003gef.3_RNA|WHSC1_uc003gei.3_Missense_Mutation_p.S362R|WHSC1_uc011bvh.1_Missense_Mutation_p.S204R|WHSC1_uc010icf.2_Missense_Mutation_p.S491R	NM_001042424	NP_001035889	O96028	NSD2_HUMAN	Wolf-Hirschhorn syndrome candidate 1 protein	1143	SET.				anatomical structure morphogenesis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|cytoplasm|nuclear membrane|nucleolus	DNA binding|histone-lysine N-methyltransferase activity|zinc ion binding			ovary(3)|lung(3)|skin(2)|pancreas(1)	9		all_epithelial(65;1.34e-05)	OV - Ovarian serous cystadenocarcinoma(23;0.00606)	STAD - Stomach adenocarcinoma(129;0.232)		TGAATCACAGCTGCCAGCCCA	0.507		NA	T	IGH@	MM								53	109					1.77e-36	1.99e-36	1	0
HGFAC	3083	broad.mit.edu	37	4	3444828	3444828	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr4:3444828G>A	uc003ghc.2	+	3	353	c.350G>A	c.(349-351)CGC>CAC	p.R117H	HGFAC_uc010icw.2_Missense_Mutation_p.R117H	NM_001528	NP_001519	Q04756	HGFA_HUMAN	HGF activator preproprotein	117	Fibronectin type-II.				proteolysis	extracellular space	protein binding|serine-type endopeptidase activity			central_nervous_system(2)	2				UCEC - Uterine corpus endometrioid carcinoma (64;0.163)		TACGGGGGCCGCATGCTGCAT	0.721		NA											3	16					0	0	0	0
TBC1D19	55296	broad.mit.edu	37	4	26719590	26719590	+	Silent	SNP	G	G	A			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr4:26719590G>A	uc003gsf.3	+	14	1260	c.990G>A	c.(988-990)TTG>TTA	p.L330L	TBC1D19_uc010iew.2_Silent_p.L330L|TBC1D19_uc011bxu.1_Silent_p.L265L	NM_018317	NP_060787	Q8N5T2	TBC19_HUMAN	TBC1 domain family, member 19	330	Rab-GAP TBC.					intracellular	Rab GTPase activator activity			breast(1)	1		Breast(46;0.0503)				CATCTGTGTTGAGTCACTTTG	0.303		NA											34	105					0	0	0	0
ANKRD17	26057	broad.mit.edu	37	4	73990774	73990774	+	Silent	SNP	A	A	G			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr4:73990774A>G	uc003hgp.2	-	18	3465	c.3348T>C	c.(3346-3348)GGT>GGC	p.G1116G	ANKRD17_uc003hgo.2_Silent_p.G1003G|ANKRD17_uc003hgq.2_Silent_p.G865G|ANKRD17_uc003hgr.2_Silent_p.G1115G|ANKRD17_uc011cbd.1_Silent_p.G681G	NM_032217	NP_115593	O75179	ANR17_HUMAN	ankyrin repeat domain protein 17 isoform a	1116	ANK 17.				interspecies interaction between organisms	cytoplasm|nucleus	RNA binding			ovary(5)|skin(3)|upper_aerodigestive_tract(1)|lung(1)	10	Breast(15;0.000295)		Epithelial(6;8.86e-07)|OV - Ovarian serous cystadenocarcinoma(6;6.22e-06)|all cancers(17;1.51e-05)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			GTGGAGTAAAACCTGGAGAAA	0.378		NA											28	84					0	0	0	0
MAPKSP1	8649	broad.mit.edu	37	4	100808471	100808471	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr4:100808471C>T	uc003hvg.2	-	4	334	c.85G>A	c.(85-87)GGA>AGA	p.G29R	MAPKSP1_uc003hvi.2_RNA|MAPKSP1_uc003hvh.2_Missense_Mutation_p.G29R	NM_021970	NP_068805	Q9UHA4	LTOR3_HUMAN	MAPK scaffold protein 1	29					cellular protein localization|cellular response to amino acid stimulus|positive regulation of TOR signaling cascade	Ragulator complex	protein binding				0						ACAGGTACTCCATCTCTATCT	0.269		NA											7	35					0	0	0	0
PAPSS1	9061	broad.mit.edu	37	4	108552816	108552816	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr4:108552816C>G	uc003hyk.2	-	11	1791	c.1707G>C	c.(1705-1707)AAG>AAC	p.K569N		NM_005443	NP_005434	O43252	PAPS1_HUMAN	3'-phosphoadenosine 5'-phosphosulfate synthase	569	Adenylyl-sulfate kinase.				3'-phosphoadenosine 5'-phosphosulfate biosynthetic process|skeletal system development|sulfate assimilation|xenobiotic metabolic process	cytosol	adenylylsulfate kinase activity|ATP binding|sulfate adenylyltransferase (ATP) activity			ovary(1)	1		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;5.49e-05)		CCATACGCTTCTTTTTCTTGT	0.423		NA											45	174					0	0	0	0
CASP6	839	broad.mit.edu	37	4	110612108	110612108	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr4:110612108G>A	uc003hzn.1	-	6	619	c.541C>T	c.(541-543)CAG>TAG	p.Q181*	CASP6_uc003hzo.1_Nonsense_Mutation_p.Q92*	NM_001226	NP_001217	P55212	CASP6_HUMAN	caspase 6 isoform alpha preproprotein	181					cellular component disassembly involved in apoptosis|induction of apoptosis|proteolysis	cytosol|nucleoplasm	cysteine-type endopeptidase activity|protein binding			ovary(1)|breast(1)	2		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.000171)		TTCTCTGTCTGATTATCTACT	0.488		NA											24	84					0	0	0	0
DCHS2	54798	broad.mit.edu	37	4	155256201	155256201	+	Silent	SNP	C	C	T			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr4:155256201C>T	uc003inw.2	-	8	1035	c.1035G>A	c.(1033-1035)TTG>TTA	p.L345L	DCHS2_uc003inx.2_Silent_p.L844L	NM_017639	NP_060109	Q6V1P9	PCD23_HUMAN	dachsous 2 isoform 1	345	Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|pancreas(1)	4	all_hematologic(180;0.208)	Renal(120;0.0854)		LUSC - Lung squamous cell carcinoma(193;0.107)		CAGAGACCATCAACGAAAGTG	0.408		NA											25	90					0	0	0	0
SNX25	83891	broad.mit.edu	37	4	186185722	186185722	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr4:186185722C>T	uc003ixh.2	+	4	559	c.370C>T	c.(370-372)CTC>TTC	p.L124F		NM_031953	NP_114159	Q9H3E2	SNX25_HUMAN	sorting nexin 25	124	PXA.				cell communication|protein transport	endosome membrane	phosphatidylinositol binding|signal transducer activity			ovary(2)|breast(2)|pancreas(1)	5		all_lung(41;1.03e-13)|Lung NSC(41;2.5e-13)|Hepatocellular(41;0.00826)|Colorectal(36;0.00886)|Renal(120;0.00988)|Prostate(90;0.0235)|all_hematologic(60;0.0592)|all_neural(102;0.243)		all cancers(43;2.13e-24)|Epithelial(43;6.15e-22)|OV - Ovarian serous cystadenocarcinoma(60;5.6e-11)|BRCA - Breast invasive adenocarcinoma(30;0.00013)|Colorectal(24;0.000165)|GBM - Glioblastoma multiforme(59;0.000357)|COAD - Colon adenocarcinoma(29;0.000887)|STAD - Stomach adenocarcinoma(60;0.00118)|LUSC - Lung squamous cell carcinoma(40;0.0129)|READ - Rectum adenocarcinoma(43;0.228)		TGTGCAGTCTCTCAGCTTACG	0.403		NA											43	93					0	0	0	0
PRDM9	56979	broad.mit.edu	37	5	23526395	23526395	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr5:23526395C>G	uc003jgo.2	+	11	1380	c.1198C>G	c.(1198-1200)CAG>GAG	p.Q400E		NM_020227	NP_064612	Q9NQV7	PRDM9_HUMAN	PR domain containing 9	400	C2H2-type 1.				meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleoplasm	histone-lysine N-methyltransferase activity|nucleic acid binding|zinc ion binding			ovary(3)|large_intestine(2)|pancreas(1)	6						CTTTTCAAGTCAGAAATTTCT	0.473		NA								HNSCC(3;0.000094)			34	203					0	0	0	0
ADAMTS12	81792	broad.mit.edu	37	5	33649669	33649669	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr5:33649669G>A	uc003jia.1	-	8	1487	c.1324C>T	c.(1324-1326)CGC>TGC	p.R442C	ADAMTS12_uc010iuq.1_Missense_Mutation_p.R442C	NM_030955	NP_112217	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1	442	Peptidase M12B.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|kidney(1)	9						TCCAAGAAGCGGGTGATGTAC	0.532		NA								HNSCC(64;0.19)			9	132					0	0	0	0
NIPBL	25836	broad.mit.edu	37	5	36985741	36985741	+	Missense_Mutation	SNP	A	A	G			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr5:36985741A>G	uc003jkl.3	+	10	2958	c.2459A>G	c.(2458-2460)AAT>AGT	p.N820S	NIPBL_uc003jkk.3_Missense_Mutation_p.N820S|NIPBL_uc003jkm.1_Missense_Mutation_p.N699S	NM_133433	NP_597677	Q6KC79	NIPBL_HUMAN	delangin isoform A	820					brain development|cellular protein localization|cellular response to X-ray|cognition|developmental growth|ear morphogenesis|embryonic arm morphogenesis|embryonic digestive tract morphogenesis|external genitalia morphogenesis|eye morphogenesis|face morphogenesis|gall bladder development|maintenance of mitotic sister chromatid cohesion|metanephros development|negative regulation of transcription from RNA polymerase II promoter|outflow tract morphogenesis|positive regulation of histone deacetylation|regulation of developmental growth|regulation of embryonic development|regulation of hair cycle|response to DNA damage stimulus|sensory perception of sound|uterus morphogenesis	SMC loading complex	chromo shadow domain binding|histone deacetylase binding|protein C-terminus binding|protein N-terminus binding			ovary(4)|lung(2)|large_intestine(1)|breast(1)|kidney(1)	9	all_lung(31;0.000447)|Hepatocellular(1;0.108)		Epithelial(62;0.072)|COAD - Colon adenocarcinoma(61;0.14)|all cancers(62;0.191)|Colorectal(62;0.202)			GACCATGATAATAAACAAAAA	0.438		NA											6	129					0	0	0	0
DAB2	1601	broad.mit.edu	37	5	39392478	39392478	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr5:39392478C>T	uc003jlx.2	-	4	850	c.319G>A	c.(319-321)GAG>AAG	p.E107K	DAB2_uc003jlw.2_Missense_Mutation_p.E107K	NM_001343	NP_001334	P98082	DAB2_HUMAN	disabled homolog 2	107	PID.				cell proliferation|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of protein binding|negative regulation of transcription, DNA-dependent|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of transcription, DNA-dependent|positive regulation of Wnt receptor signaling pathway, planar cell polarity pathway	clathrin coated vesicle membrane|coated pit	protein C-terminus binding			kidney(2)|skin(1)	3	all_lung(31;0.000197)		Epithelial(62;0.137)			CCAGTTTTCTCATCAATTATT	0.463		NA											21	118					0	0	0	0
PDE4D	5144	broad.mit.edu	37	5	58285677	58285677	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr5:58285677C>T	uc003jsa.2	-	10	1529	c.1357G>A	c.(1357-1359)GAC>AAC	p.D453N	PDE4D_uc003jrx.2_Missense_Mutation_p.D317N|PDE4D_uc003jry.2_Missense_Mutation_p.D151N|PDE4D_uc003jrz.2_Missense_Mutation_p.D389N|PDE4D_uc003jsb.2_Missense_Mutation_p.D392N|PDE4D_uc003jrt.2_Missense_Mutation_p.D151N|PDE4D_uc003jru.2_Missense_Mutation_p.D229N|PDE4D_uc003jrv.2_Missense_Mutation_p.D323N|PDE4D_uc003jrw.2_Missense_Mutation_p.D331N|PDE4D_uc003jrs.2_Missense_Mutation_p.D162N	NM_001104631	NP_001098101	Q08499	PDE4D_HUMAN	phosphodiesterase 4D isoform 1	453					signal transduction	cytosol|insoluble fraction|membrane|microtubule organizing center|soluble fraction	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding			breast(1)|central_nervous_system(1)	2		all_cancers(5;6.5e-58)|all_epithelial(5;1.75e-57)|all_lung(5;6.84e-18)|Lung NSC(5;1.29e-17)|Melanoma(5;0.00168)|Prostate(74;0.00234)|Colorectal(97;0.00629)|Ovarian(174;0.00832)|Breast(144;0.00996)|all_hematologic(6;0.0344)|Hepatocellular(6;0.0742)|Esophageal squamous(6;0.0954)		Epithelial(2;2.6e-55)|all cancers(2;2.66e-49)|OV - Ovarian serous cystadenocarcinoma(10;1.48e-39)|Colorectal(2;8.29e-08)|Lung(2;4.47e-07)|STAD - Stomach adenocarcinoma(2;1.11e-05)|COAD - Colon adenocarcinoma(2;0.00012)|LUSC - Lung squamous cell carcinoma(2;0.000775)|LUAD - Lung adenocarcinoma(3;0.0173)|READ - Rectum adenocarcinoma(2;0.0276)	Adenosine monophosphate(DB00131)|Dyphylline(DB00651)	TGGTAATGGTCTTCGAGAGTC	0.343		NA											17	72					0	0	0	0
MEF2C	4208	broad.mit.edu	37	5	88018491	88018491	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr5:88018491C>T	uc003kjj.2	-	11	2025	c.1352G>A	c.(1351-1353)AGA>AAA	p.R451K	MEF2C_uc003kji.2_Missense_Mutation_p.R443K|MEF2C_uc003kjk.2_Missense_Mutation_p.R451K|MEF2C_uc003kjm.2_Missense_Mutation_p.R441K|MEF2C_uc003kjl.2_Missense_Mutation_p.R461K	NM_002397	NP_002388	Q06413	MEF2C_HUMAN	myocyte enhancer factor 2C isoform 1	451					apoptosis|B cell proliferation|innate immune response|learning or memory|muscle cell differentiation|muscle organ development|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|nerve growth factor receptor signaling pathway|neuron development|positive regulation of muscle cell differentiation|positive regulation of survival gene product expression|positive regulation of transcription from RNA polymerase II promoter|regulation of germinal center formation|regulation of megakaryocyte differentiation|regulation of synaptic activity|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	nuclear speck	activating transcription factor binding|protein heterodimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			lung(3)|breast(2)|ovary(1)|large_intestine(1)	7		all_cancers(142;6.67e-05)|all_epithelial(76;7.77e-07)|Lung NSC(167;0.00566)|all_lung(232;0.00732)|Colorectal(57;0.0959)|Ovarian(174;0.1)		OV - Ovarian serous cystadenocarcinoma(54;1.04e-33)|Epithelial(54;1.6e-28)|all cancers(79;2.9e-25)		CGGCGAAGGTCTGGTGAGTCC	0.498		NA								HNSCC(66;0.2)			66	251					0	0	0	0
SEMA6A	57556	broad.mit.edu	37	5	115783452	115783452	+	Silent	SNP	G	G	A			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr5:115783452G>A	uc010jck.2	-	19	2659	c.1950C>T	c.(1948-1950)CTC>CTT	p.L650L	SEMA6A_uc003krx.3_Silent_p.L667L|SEMA6A_uc011cwe.1_Silent_p.L29L|SEMA6A_uc003krv.3_Silent_p.L77L|SEMA6A_uc003krw.3_Silent_p.L127L|SEMA6A_uc010jcj.2_Silent_p.L194L	NM_020796	NP_065847	Q9H2E6	SEM6A_HUMAN	sema domain, transmembrane domain (TM), and	650	Helical; (Potential).				apoptosis|axon guidance|cell surface receptor linked signaling pathway|cytoskeleton organization|organ morphogenesis	axon|integral to membrane|plasma membrane	receptor activity			ovary(2)	2		all_cancers(142;0.00316)|all_epithelial(76;5.71e-05)|Prostate(80;0.00845)|Ovarian(225;0.0796)|Lung NSC(810;0.171)|all_lung(232;0.203)		OV - Ovarian serous cystadenocarcinoma(64;1.59e-08)|Epithelial(69;2e-08)|all cancers(49;5.7e-08)|COAD - Colon adenocarcinoma(49;0.151)		CAATGGCCAAGAGGGTGACGG	0.552		NA											5	29					0	0	0	0
ADAMTS19	171019	broad.mit.edu	37	5	128862009	128862009	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr5:128862009G>A	uc003kvb.1	+	4	928	c.928G>A	c.(928-930)GAA>AAA	p.E310K	ADAMTS19_uc003kvc.1_RNA	NM_133638	NP_598377	Q8TE59	ATS19_HUMAN	ADAM metallopeptidase with thrombospondin type 1	310					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(5)|breast(2)|lung(1)|skin(1)	9		all_cancers(142;0.0148)|Prostate(80;0.0494)|Breast(839;0.238)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	OV - Ovarian serous cystadenocarcinoma(64;0.222)		AAAAATAGCAGAAAGTGGAAG	0.358		NA											18	57					0	0	0	0
HSPA4	3308	broad.mit.edu	37	5	132400683	132400683	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr5:132400683C>G	uc003kyj.2	+	2	400	c.119C>G	c.(118-120)TCT>TGT	p.S40C		NM_002154	NP_002145	P34932	HSP74_HUMAN	heat shock 70kDa protein 4	40					cellular chaperone-mediated protein complex assembly|protein import into mitochondrial outer membrane|response to unfolded protein	cytoplasm|nucleus	ATP binding			lung(1)|breast(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			GCTTGCATTTCTTTTGGTCCT	0.323		NA											33	161					0	0	0	0
PCDHA1	56147	broad.mit.edu	37	5	140165886	140165886	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr5:140165886C>A	uc003lhb.2	+	1	11	c.11C>A	c.(10-12)TCT>TAT	p.S4Y	PCDHA1_uc003lha.2_Missense_Mutation_p.S4Y|PCDHA1_uc003lgz.2_Missense_Mutation_p.S4Y	NM_018900	NP_061723	Q9Y5I3	PCDA1_HUMAN	protocadherin alpha 1 isoform 1 precursor	4					homophilic cell adhesion|nervous system development	extracellular region|integral to plasma membrane	calcium ion binding|protein binding			skin(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ATGGTGTTTTCTAGGAGAGGG	0.502		NA											47	225					2.76e-25	3.1e-25	1	0
PCDH12	51294	broad.mit.edu	37	5	141336011	141336011	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr5:141336011G>A	uc003llx.2	-	1	2617	c.1406C>T	c.(1405-1407)ACG>ATG	p.T469M		NM_016580	NP_057664	Q9NPG4	PCD12_HUMAN	protocadherin 12 precursor	469	Extracellular (Potential).|Cadherin 5.				neuron recognition	integral to plasma membrane	calcium ion binding			ovary(3)	3		all_hematologic(541;0.0999)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GTTTTCCCGCGTGGAGACTTC	0.478		NA											35	143					0	0	0	0
SH3RF2	153769	broad.mit.edu	37	5	145379752	145379752	+	Silent	SNP	C	C	T	rs137960488		TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr5:145379752C>T	uc003lnt.2	+	3	748	c.510C>T	c.(508-510)ATC>ATT	p.I170I	SH3RF2_uc011dbl.1_Silent_p.I170I	NM_152550	NP_689763	Q8TEC5	SH3R2_HUMAN	SH3 domain containing ring finger 2	170	SH3 1.						ligase activity|protein phosphatase 1 binding|zinc ion binding			ovary(1)|skin(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			TCAATGGCATCAGCGGGAACT	0.567		NA											19	81					0	0	0	0
GABRG2	2566	broad.mit.edu	37	5	161524718	161524718	+	Silent	SNP	C	C	T			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr5:161524718C>T	uc003lyz.3	+	4	760	c.402C>T	c.(400-402)GTC>GTT	p.V134V	GABRG2_uc010jjc.2_Silent_p.V134V|GABRG2_uc003lyy.3_Silent_p.V134V|GABRG2_uc011dej.1_Silent_p.V39V	NM_000816	NP_000807	P18507	GBRG2_HUMAN	gamma-aminobutyric acid A receptor, gamma 2	134	Extracellular (Probable).				gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity|protein binding			ovary(4)|skin(1)	5	Renal(175;0.000319)	Medulloblastoma(196;0.0208)|all_neural(177;0.0672)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0734)|OV - Ovarian serous cystadenocarcinoma(192;0.135)|Epithelial(171;0.136)		CCATTAAAGTCCTCCGATTGA	0.378		NA											30	128					0	0	0	0
SERPINB6	5269	broad.mit.edu	37	6	2948610	2948610	+	Silent	SNP	G	G	A			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr6:2948610G>A	uc003muk.2	-	6	3048	c.1053C>T	c.(1051-1053)GCC>GCT	p.A351A	SERPINB6_uc003mui.2_Silent_p.A234A|SERPINB6_uc003muj.2_RNA|SERPINB6_uc003mul.2_Silent_p.A351A|SERPINB6_uc003mum.2_Silent_p.A351A|SERPINB6_uc003mun.2_Silent_p.A351A|SERPINB6_uc003muo.2_Silent_p.A351A	NM_004568	NP_004559	P35237	SPB6_HUMAN	serine (or cysteine) proteinase inhibitor, clade	351					regulation of proteolysis	centrosome|cytosol|protein complex	protease binding|serine-type endopeptidase inhibitor activity				0	Ovarian(93;0.0412)	all_hematologic(90;0.0895)			Drotrecogin alfa(DB00055)	AGGGGTGGTCGGCGCAGAAGC	0.587		NA											13	58					0	0	0	0
HIST1H2BK	85236	broad.mit.edu	37	6	27114238	27114238	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr6:27114238C>T	uc003nix.1	-	1	382	c.340G>A	c.(340-342)GAG>AAG	p.E114K	HIST1H2AH_uc003niz.2_5'Flank|hsa-mir-3143|MI0014167_5'Flank	NM_080593	NP_542160	O60814	H2B1K_HUMAN	histone cluster 1, H2bk	114					defense response to bacterium|nucleosome assembly	nucleosome|nucleus	DNA binding				0						TTGGTGCCCTCGGACACGGCG	0.582		NA											28	125					0	0	0	0
GABBR1	2550	broad.mit.edu	37	6	29591083	29591083	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr6:29591083G>A	uc003nmt.3	-	8	1298	c.962C>T	c.(961-963)TCG>TTG	p.S321L	GABBR1_uc003nmp.3_Missense_Mutation_p.S204L|GABBR1_uc003nms.3_Missense_Mutation_p.S204L|GABBR1_uc003nmu.3_Missense_Mutation_p.S259L|GABBR1_uc011dlr.1_Missense_Mutation_p.S144L|GABBR1_uc011dls.1_Missense_Mutation_p.S321L	NM_001470	NP_001461	Q9UBS5	GABR1_HUMAN	gamma-aminobutyric acid (GABA) B receptor 1	321	Extracellular (Potential).				gamma-aminobutyric acid signaling pathway|negative regulation of adenylate cyclase activity|synaptic transmission	cell junction|extracellular region|integral to plasma membrane|postsynaptic membrane	G-protein coupled receptor activity|GABA-B receptor activity			ovary(5)|liver(1)|skin(1)	7					Baclofen(DB00181)|Progabide(DB00837)	CCTCCTCACCGAAGTGAAGAC	0.517		NA											13	50					0	0	0	0
MDFI	4188	broad.mit.edu	37	6	41621181	41621181	+	Silent	SNP	C	C	T			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr6:41621181C>T	uc003oqp.3	+	6	938	c.609C>T	c.(607-609)TGC>TGT	p.C203C	MDFI_uc003oqq.3_Silent_p.C203C|MDFI_uc010jxn.2_Silent_p.C203C	NM_005586	NP_005577	Q99750	MDFI_HUMAN	MyoD family inhibitor	203	Cys-rich.				cytoplasmic sequestering of transcription factor|dorsal/ventral axis specification|negative regulation of DNA binding|negative regulation of transcription from RNA polymerase II promoter|negative regulation of Wnt receptor signaling pathway	cytoplasm|nucleus					0	Ovarian(28;0.0327)|Colorectal(47;0.121)		Colorectal(64;0.0123)|COAD - Colon adenocarcinoma(64;0.0264)|KIRC - Kidney renal clear cell carcinoma(1;0.138)			GCTGCTGCTGCTGTGGCTCTG	0.657		NA											3	105					0	0	0	0
FRS3	10817	broad.mit.edu	37	6	41738550	41738550	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr6:41738550C>T	uc003orc.1	-	7	1530	c.1286G>A	c.(1285-1287)CGC>CAC	p.R429H		NM_006653	NP_006644	O43559	FRS3_HUMAN	fibroblast growth factor receptor substrate 3	429					fibroblast growth factor receptor signaling pathway	plasma membrane	fibroblast growth factor receptor binding|insulin receptor binding			ovary(2)	2	Ovarian(28;0.0355)|Colorectal(47;0.121)		Epithelial(12;8.38e-05)|STAD - Stomach adenocarcinoma(11;0.000204)|Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)			CCCCTTAGGGCGGTCTCCACC	0.637		NA											6	74					0	0	0	0
GPR111	222611	broad.mit.edu	37	6	47649665	47649665	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr6:47649665C>G	uc010jzj.1	+	6	1371	c.1370C>G	c.(1369-1371)TCT>TGT	p.S457C	GPR111_uc010jzk.1_Missense_Mutation_p.S389C|GPR111_uc003oyy.2_RNA	NM_153839	NP_722581	Q8IZF7	GP111_HUMAN	G-protein coupled receptor 111	457	Helical; Name=1; (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			skin(1)	1						CTGGGCATTTCTATTTGCAGC	0.428		NA											60	187					0	0	0	0
TBX18	9096	broad.mit.edu	37	6	85469990	85469990	+	Silent	SNP	C	C	G			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr6:85469990C>G	uc003pkl.1	-	3	582	c.582G>C	c.(580-582)GTG>GTC	p.V194V	TBX18_uc010kbq.1_Silent_p.V36V	NM_001080508	NP_001073977	O95935	TBX18_HUMAN	T-box 18	194	T-box.				multicellular organismal development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(2)|pancreas(2)|lung(1)	5		all_cancers(76;0.000283)|Acute lymphoblastic leukemia(125;3.66e-08)|all_hematologic(105;8.61e-05)|all_epithelial(107;0.0858)		BRCA - Breast invasive adenocarcinoma(108;0.0267)		TTTTGTTGTCCACTGGTACAA	0.388		NA											11	69					0	0	0	0
MCM9	254394	broad.mit.edu	37	6	119245170	119245170	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr6:119245170G>A	uc003pyh.2	-	3	690	c.427C>T	c.(427-429)CGG>TGG	p.R143W		NM_153255	NP_694987	Q9NXL9	MCM9_HUMAN	minichromosome maintenance complex component 9	143					DNA replication		ATP binding|DNA binding|nucleoside-triphosphatase activity			ovary(1)	1		all_cancers(87;0.122)|all_epithelial(87;0.179)		GBM - Glioblastoma multiforme(226;0.0676)|OV - Ovarian serous cystadenocarcinoma(136;0.194)		ATGTAATCCCGCTCAAACTCC	0.468		NA											5	350					0	0	0	0
KIAA1244	57221	broad.mit.edu	37	6	138576900	138576900	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr6:138576900G>A	uc003qhu.2	+	10	1098	c.1098G>A	c.(1096-1098)ATG>ATA	p.M366I		NM_020340	NP_065073	Q5TH69	BIG3_HUMAN	brefeldin A-inhibited guanine	366					regulation of ARF protein signal transduction	cytoplasm|integral to membrane	ARF guanyl-nucleotide exchange factor activity			ovary(1)|skin(1)	2	Breast(32;0.135)			OV - Ovarian serous cystadenocarcinoma(155;0.00102)|GBM - Glioblastoma multiforme(68;0.00259)		TCAAAATAATGAAAGAGGTGA	0.572		NA											5	8					0	0	0	0
TTLL2	83887	broad.mit.edu	37	6	167754382	167754382	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr6:167754382C>T	uc003qvs.1	+	3	1082	c.994C>T	c.(994-996)CGT>TGT	p.R332C	TTLL2_uc011egr.1_RNA	NM_031949	NP_114155	Q9BWV7	TTLL2_HUMAN	tubulin tyrosine ligase-like family, member 2	332	TTL.				protein modification process		ATP binding|tubulin-tyrosine ligase activity			ovary(1)|central_nervous_system(1)|skin(1)	3		Breast(66;7.8e-06)|Ovarian(120;0.024)		OV - Ovarian serous cystadenocarcinoma(33;2.22e-20)|BRCA - Breast invasive adenocarcinoma(81;6.17e-07)|GBM - Glioblastoma multiforme(31;0.00492)		TTCCTACCTTCGTAGCTGGGA	0.463		NA											81	256					0	0	0	0
SDK1	221935	broad.mit.edu	37	7	4169596	4169596	+	Silent	SNP	G	G	A			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr7:4169596G>A	uc003smx.2	+	27	4135	c.3996G>A	c.(3994-3996)GGG>GGA	p.G1332G	SDK1_uc010kso.2_Silent_p.G608G|SDK1_uc003smy.2_5'UTR	NM_152744	NP_689957	Q7Z5N4	SDK1_HUMAN	sidekick 1 precursor	1332	Fibronectin type-III 7.				cell adhesion	integral to membrane				large_intestine(3)|ovary(2)|skin(1)	6		all_cancers(1;0.127)|Ovarian(82;0.0177)|Myeloproliferative disorder(862;0.194)		UCEC - Uterine corpus endometrioid carcinoma (126;0.121)|OV - Ovarian serous cystadenocarcinoma(56;9.65e-15)		TCGTGCGAGGGAACCACACGC	0.652		NA											25	72					0	0	0	0
MPP6	51678	broad.mit.edu	37	7	24727123	24727123	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr7:24727123G>A	uc003swx.2	+	13	1812	c.1513G>A	c.(1513-1515)GAT>AAT	p.D505N	MPP6_uc003swy.2_Missense_Mutation_p.D505N|MPP6_uc010kur.2_Missense_Mutation_p.D173N	NM_016447	NP_057531	Q9NZW5	MPP6_HUMAN	membrane protein, palmitoylated 6	505	Guanylate kinase-like.				protein complex assembly		protein binding				0						CCACTATTTTGATTTGATCAT	0.378		NA											46	186					0	0	0	0
HNRNPA2B1	3181	broad.mit.edu	37	7	26232925	26232925	+	Missense_Mutation	SNP	T	T	C			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr7:26232925T>C	uc003sxr.3	-	10	1162	c.946A>G	c.(946-948)ATG>GTG	p.M316V	HNRNPA2B1_uc003sxs.3_Missense_Mutation_p.M304V	NM_031243	NP_112533	P22626	ROA2_HUMAN	heterogeneous nuclear ribonucleoprotein A2/B1	316	Gly-rich.|Nuclear targeting sequence (By similarity).				RNA transport	catalytic step 2 spliceosome|cytoplasm|heterogeneous nuclear ribonucleoprotein complex|nucleolus|nucleoplasm	nucleotide binding|protein binding|protein binding|RNA binding|single-stranded telomeric DNA binding			ovary(1)|central_nervous_system(1)|skin(1)	3						CCACTCTTCATTGGACCGTAG	0.343		NA	T	ETV1	prostate								4	176					0	0	0	0
CBX3	11335	broad.mit.edu	37	7	26251377	26251377	+	Splice_Site	SNP	G	G	C			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr7:26251377G>C	uc003sxt.2	+	5	536	c.425_splice	c.e5+1	p.W142_splice	CBX3_uc003sxu.2_Splice_Site_p.W142_splice|CBX3_uc003sxv.2_Splice_Site	NM_007276	NP_009207	Q13185	CBX3_HUMAN	chromobox homolog 3						chromatin remodeling|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	condensed chromosome, centromeric region|nuclear centromeric heterochromatin|nuclear euchromatin|nuclear inner membrane|spindle	enzyme binding|protein domain specific binding			ovary(1)	1						TCATGAAATGGTGAGTATGCA	0.368		NA											21	62					0	0	0	0
SFRP4	6424	broad.mit.edu	37	7	37955829	37955829	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr7:37955829G>T	uc003tfo.3	-	1	697	c.311C>A	c.(310-312)GCG>GAG	p.A104E		NM_003014	NP_003005	Q6FHJ7	SFRP4_HUMAN	secreted frizzled-related  protein 4 precursor	104	FZ.				brain development|cell differentiation|decidualization|embryo development|epithelium development|gonad development|mammary gland involution|menstrual cycle phase|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cell proliferation|negative regulation of JNK cascade|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of sodium-dependent phosphate transport|phosphate ion homeostasis|positive regulation of apoptosis|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of epidermal cell differentiation|positive regulation of gene expression|positive regulation of receptor internalization|vasculature development|Wnt receptor signaling pathway	cell surface|cytoplasm|extracellular space|nucleus	PDZ domain binding|Wnt receptor activity|Wnt-protein binding			lung(1)	1						GTCGTCGCGCGCGCGTTGGCA	0.627		NA											17	46					6.94e-10	7.61e-10	1	0
ADCY1	107	broad.mit.edu	37	7	45753466	45753466	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr7:45753466G>T	uc003tne.3	+	20	3250	c.3232G>T	c.(3232-3234)GGG>TGG	p.G1078W		NM_021116	NP_066939	Q08828	ADCY1_HUMAN	adenylate cyclase 1	1078	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|calmodulin binding|metal ion binding			ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	6					Adenosine(DB00640)|Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)	GTGTCCATTTGGGAGAGCTGG	0.602		NA											30	111					1.75e-11	1.92e-11	1	0
NAA38	51691	broad.mit.edu	37	7	117828389	117828389	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr7:117828389C>T	uc003vjg.2	+	3	322	c.130C>T	c.(130-132)CGA>TGA	p.R44*		NM_016200	NP_057284	O95777	NAA38_HUMAN	U6 snRNA-associated Sm-like protein LSm8	44					nuclear mRNA splicing, via spliceosome	nucleus|ribonucleoprotein complex	protein binding|U6 snRNA binding				0						AAGCCATGAACGAGTATTCAG	0.338		NA											41	138					0	0	0	0
AKR1B10	57016	broad.mit.edu	37	7	134216705	134216705	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr7:134216705G>C	uc003vrr.2	+	3	600	c.280G>C	c.(280-282)GAG>CAG	p.E94Q		NM_020299	NP_064695	O60218	AK1BA_HUMAN	aldo-keto reductase family 1, member B10	94					cellular aldehyde metabolic process|digestion|steroid metabolic process	cytoplasm	aldo-keto reductase (NADP) activity|protein binding			skin(5)	5						GAAAGCCTTTGAGAAGACCCT	0.468		NA											40	150					0	0	0	0
MGAM	8972	broad.mit.edu	37	7	141765212	141765212	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr7:141765212G>C	uc003vwy.2	+	38	4616	c.4562G>C	c.(4561-4563)GGA>GCA	p.G1521A		NM_004668	NP_004659	O43451	MGA_HUMAN	maltase-glucoamylase	1521	Glucoamylase.|Lumenal (Potential).				polysaccharide digestion|starch catabolic process	apical plasma membrane|integral to membrane	carbohydrate binding|glucan 1,4-alpha-glucosidase activity|maltose alpha-glucosidase activity			ovary(2)	2	Melanoma(164;0.0272)				Acarbose(DB00284)|Miglitol(DB00491)|Voglibose(DB04878)	CGCTGGGCAGGACATTGGCTG	0.622		NA											4	11					0	0	0	0
C7orf29	113763	broad.mit.edu	37	7	150028028	150028028	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr7:150028028G>A	uc003wgy.2	+	1	1091	c.535G>A	c.(535-537)GAG>AAG	p.E179K	LRRC61_uc003wgv.2_Intron|LRRC61_uc003wgx.2_Intron|LRRC61_uc003wgw.2_Intron	NM_138434	NP_612443	Q96FA7	CG029_HUMAN	hypothetical protein LOC113763	179										ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(82;0.011)			GCTGGCCTCTGAGAGAAGCGG	0.627		NA											7	54					0	0	0	0
DPP6	1804	broad.mit.edu	37	7	154679393	154679393	+	Silent	SNP	G	G	A			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr7:154679393G>A	uc003wlk.2	+	23	2382	c.2253G>A	c.(2251-2253)GCG>GCA	p.A751A	DPP6_uc003wli.2_Silent_p.A687A|DPP6_uc003wlm.2_Silent_p.A689A|DPP6_uc011kvq.1_Silent_p.A644A	NM_130797	NP_570629	P42658	DPP6_HUMAN	dipeptidyl-peptidase 6 isoform 1	751	Extracellular (Potential).				cell death|proteolysis	integral to membrane	dipeptidyl-peptidase activity|serine-type peptidase activity			pancreas(3)|breast(1)	4	all_neural(206;0.181)	all_hematologic(28;0.0044)|all_lung(21;0.0176)|Lung NSC(21;0.0204)	OV - Ovarian serous cystadenocarcinoma(82;0.0562)			CAGCCTCTGCGTTTTCCGAGA	0.592		NA											69	241					0	0	0	0
TM7SF4	81501	broad.mit.edu	37	8	105367308	105367308	+	Silent	SNP	C	C	T			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr8:105367308C>T	uc003ylx.1	+	3	1282	c.1233C>T	c.(1231-1233)AGC>AGT	p.S411S		NM_030788	NP_110415	Q9H295	TM7S4_HUMAN	dendritic cell-specific transmembrane protein	411	Cytoplasmic.				osteoclast differentiation	cell surface|integral to membrane|plasma membrane				pancreas(2)|large_intestine(1)|ovary(1)	4			OV - Ovarian serous cystadenocarcinoma(57;1.61e-06)|STAD - Stomach adenocarcinoma(118;0.229)			TCTACCCCAGCGTGGAGAGGA	0.438		NA											36	242					0	0	0	0
CSMD3	114788	broad.mit.edu	37	8	113599423	113599423	+	Silent	SNP	G	G	A			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr8:113599423G>A	uc003ynu.2	-	23	3916	c.3757C>T	c.(3757-3759)CTG>TTG	p.L1253L	CSMD3_uc003yns.2_Silent_p.L525L|CSMD3_uc003ynt.2_Silent_p.L1213L|CSMD3_uc011lhx.1_Silent_p.L1149L	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	1253	Extracellular (Potential).|CUB 7.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						TTTGGAGACAGCAAAATTCCT	0.353		NA								HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			29	222					0	0	0	0
TRPS1	7227	broad.mit.edu	37	8	116599315	116599315	+	Silent	SNP	A	A	C			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr8:116599315A>C	uc003ynz.2	-	4	3033	c.2574T>G	c.(2572-2574)GCT>GCG	p.A858A	TRPS1_uc011lhy.1_Silent_p.A862A|TRPS1_uc003yny.2_Silent_p.A871A|TRPS1_uc010mcy.2_Silent_p.A858A	NM_014112	NP_054831	Q9UHF7	TRPS1_HUMAN	zinc finger transcription factor TRPS1	858					negative regulation of transcription from RNA polymerase II promoter|NLS-bearing substrate import into nucleus|regulation of chondrocyte differentiation|skeletal system development|transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)|skin(2)|pancreas(1)|lung(1)|kidney(1)	7	all_cancers(13;5.44e-23)|all_epithelial(1;2.14e-27)|Lung NSC(37;2.55e-05)|Ovarian(258;0.0219)		Epithelial(1;9.78e-37)|all cancers(1;3.14e-31)|BRCA - Breast invasive adenocarcinoma(1;2.56e-12)			TCTCTCCGCCAGCTGGCGCCC	0.577		NA							Langer-Giedion_syndrome				4	141					0	0	0	0
HAS2	3037	broad.mit.edu	37	8	122641162	122641162	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr8:122641162C>T	uc003yph.2	-	2	957	c.419G>A	c.(418-420)AGA>AAA	p.R140K		NM_005328	NP_005319	Q92819	HAS2_HUMAN	hyaluronan synthase 2	140	Cytoplasmic (Potential).					integral to plasma membrane	hyaluronan synthase activity		HAS2/PLAG1(10)	soft_tissue(10)|ovary(5)	15	Lung NSC(37;3.12e-08)|Ovarian(258;0.0254)|Hepatocellular(40;0.0997)|all_neural(195;0.142)		STAD - Stomach adenocarcinoma(47;0.00503)			TGATTTGTCTCTGCCCATGAC	0.443		NA											86	434					0	0	0	0
FER1L6	654463	broad.mit.edu	37	8	124975615	124975615	+	Silent	SNP	C	C	T			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr8:124975615C>T	uc003yqw.2	+	3	380	c.174C>T	c.(172-174)GTC>GTT	p.V58V		NM_001039112	NP_001034201	Q2WGJ9	FR1L6_HUMAN	fer-1-like 6	58	Cytoplasmic (Potential).					integral to membrane				ovary(5)|skin(5)|central_nervous_system(1)	11	Lung NSC(37;4.1e-12)|Ovarian(258;0.00438)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00186)			TCTTTCCTGTCCCCTCAGCTT	0.368		NA											111	123					0	0	0	0
HSF1	3297	broad.mit.edu	37	8	145533469	145533469	+	Silent	SNP	G	G	A			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr8:145533469G>A	uc003zbt.3	+	4	545	c.375G>A	c.(373-375)CTG>CTA	p.L125L	HSF1_uc003zbu.3_RNA	NM_005526	NP_005517	Q00613	HSF1_HUMAN	heat shock transcription factor 1	125						cytoplasm	protein binding|sequence-specific DNA binding transcription factor activity				0	all_cancers(97;6.64e-12)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;3.94e-40)|Epithelial(56;1.12e-39)|all cancers(56;9.11e-35)|BRCA - Breast invasive adenocarcinoma(115;0.0547)|Colorectal(110;0.055)			TGTCCACCCTGAAGAGTGAAG	0.597		NA											18	117					0	0	0	0
KIAA2026	158358	broad.mit.edu	37	9	5920675	5920675	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr9:5920675G>C	uc003zjq.3	-	8	5537	c.5321C>G	c.(5320-5322)TCT>TGT	p.S1774C	KIAA2026_uc010mht.2_Missense_Mutation_p.S949C	NM_001017969	NP_001017969	Q5HYC2	K2026_HUMAN	hypothetical protein LOC158358	1774										ovary(2)|central_nervous_system(1)	3		Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.00155)|Lung(218;0.124)		AATAGATACAGAACGTGTGGC	0.423		NA											4	467					0	0	0	0
SH3GL2	6456	broad.mit.edu	37	9	17791298	17791298	+	Missense_Mutation	SNP	A	A	T			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr9:17791298A>T	uc003zna.2	+	7	982	c.694A>T	c.(694-696)ATC>TTC	p.I232F	SH3GL2_uc011lmy.1_Missense_Mutation_p.I185F	NM_003026	NP_003017	Q99962	SH3G2_HUMAN	SH3-domain GRB2-like 2	232	BAR.|Potential.				axon guidance|central nervous system development|endocytosis|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|post-Golgi vesicle-mediated transport	cytosol|Golgi membrane|plasma membrane	identical protein binding|lipid binding			skin(1)	1				GBM - Glioblastoma multiforme(50;2.71e-10)|Lung(42;0.203)		GGCAGTCCAGATCCTGCAGCA	0.433		NA											34	131					0	0	0	0
CDKN2A	1029	broad.mit.edu	37	9	21971120	21971120	+	Nonsense_Mutation	SNP	G	G	A	rs121913388		TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr9:21971120G>A	uc003zpk.2	-	2	450	c.238C>T	c.(238-240)CGA>TGA	p.R80*	MTAP_uc003zpi.1_Intron|CDKN2A_uc003zpj.2_3'UTR|CDKN2A_uc010miu.2_RNA|CDKN2A_uc003zpl.2_Missense_Mutation_p.P135L	NM_000077	NP_000068	P42771	CD2A1_HUMAN	cyclin-dependent kinase inhibitor 2A isoform 1	80	ANK 3.		R -> P (in CMM2; loss of CDK4 binding).|R -> L (in a head and neck tumor).		cell cycle arrest|cell cycle checkpoint|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of cell-matrix adhesion|negative regulation of cyclin-dependent protein kinase activity|negative regulation of NF-kappaB transcription factor activity|positive regulation of macrophage apoptosis|positive regulation of smooth muscle cell apoptosis|Ras protein signal transduction|replicative senescence	cytosol|nucleus	cyclin-dependent protein kinase inhibitor activity|NF-kappaB binding|protein binding|protein binding|protein kinase binding	p.0?(1112)|p.R80*(88)|p.?(13)|p.R80Q(2)|p.P135L(2)|p.T79fs*37(1)|p.L65fs*38(1)|p.R80fs*66(1)|p.A76fs*64(1)|p.T79fs*65(1)|p.E61_L94del(1)|p.A68fs*3(1)|p.R80fs*34(1)|p.R80?(1)|p.R80L(1)		haematopoietic_and_lymphoid_tissue(647)|skin(419)|upper_aerodigestive_tract(414)|central_nervous_system(381)|lung(325)|pancreas(244)|oesophagus(230)|urinary_tract(225)|pleura(94)|liver(91)|soft_tissue(79)|bone(77)|ovary(76)|biliary_tract(71)|stomach(46)|breast(46)|kidney(39)|NS(28)|thyroid(24)|cervix(23)|meninges(18)|genital_tract(15)|endometrium(13)|prostate(11)|autonomic_ganglia(10)|salivary_gland(10)|large_intestine(9)|adrenal_gland(6)|eye(4)|vulva(2)|small_intestine(1)	3678		all_cancers(5;0)|Acute lymphoblastic leukemia(3;0)|all_hematologic(3;0)|all_epithelial(2;2.37e-290)|Lung NSC(2;1.26e-139)|all_lung(2;4.48e-131)|Glioma(2;3.26e-60)|all_neural(2;2.1e-52)|Renal(3;1.07e-46)|Esophageal squamous(3;3.83e-46)|Melanoma(2;2.74e-34)|Breast(3;1.14e-11)|Ovarian(3;0.000128)|Hepatocellular(5;0.00162)|Colorectal(97;0.172)		all cancers(2;0)|GBM - Glioblastoma multiforme(3;0)|Lung(2;4.07e-74)|Epithelial(2;1.08e-61)|LUSC - Lung squamous cell carcinoma(2;3.82e-48)|LUAD - Lung adenocarcinoma(2;4.56e-26)|OV - Ovarian serous cystadenocarcinoma(39;7.64e-10)|BRCA - Breast invasive adenocarcinoma(2;5.01e-09)|STAD - Stomach adenocarcinoma(4;4.63e-07)|Kidney(2;5.79e-07)|KIRC - Kidney renal clear cell carcinoma(2;7.27e-07)|COAD - Colon adenocarcinoma(8;5.15e-05)		TGCACGGGTCGGGTGAGAGTG	0.726	R80*(MEWO_SKIN)|R80*(HSC4_UPPER_AERODIGESTIVE_TRACT)	17							Uveal_Melanoma_Familial|Familial_Malignant_Melanoma_and_Tumors_of_the_Nervous_System|Hereditary_Melanoma	HNSCC(2;<9.43e_08)|TSP Lung(5;3.83e-07)			10	12					0	0	0	0
C9orf11	54586	broad.mit.edu	37	9	27286284	27286284	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr9:27286284G>C	uc003zql.2	-	7	642	c.558C>G	c.(556-558)ATC>ATG	p.I186M	C9orf11_uc011lnq.1_Missense_Mutation_p.I157M	NM_020641	NP_065692	Q9NQ60	AFAF_HUMAN	Acr formation associated factor isoform 1	186	Helical; (Potential).					acrosomal membrane|integral to membrane				ovary(1)|central_nervous_system(1)	2				OV - Ovarian serous cystadenocarcinoma(39;7.39e-08)|Lung(218;1.26e-05)|LUSC - Lung squamous cell carcinoma(38;0.000106)		TCATCAACGAGATTCCCAGCA	0.458		NA											7	20					0	0	0	0
LINGO2	158038	broad.mit.edu	37	9	27949543	27949543	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr9:27949543C>A	uc003zqu.1	-	2	1321	c.1127G>T	c.(1126-1128)GGT>GTT	p.G376V	LINGO2_uc010mjf.1_Missense_Mutation_p.G376V|LINGO2_uc003zqv.1_Missense_Mutation_p.G376V	NM_152570	NP_689783	Q7L985	LIGO2_HUMAN	leucine rich repeat and Ig domain containing 2	376	LRRCT.|Extracellular (Potential).					integral to membrane				upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	3	Melanoma(11;0.242)	all_neural(11;2.78e-09)		UCEC - Uterine corpus endometrioid carcinoma (5;0.0818)|GBM - Glioblastoma multiforme(2;1.31e-34)|all cancers(2;2.37e-25)|Lung(2;7.48e-08)|LUSC - Lung squamous cell carcinoma(38;5.09e-07)|KIRC - Kidney renal clear cell carcinoma(2;0.0465)|Kidney(2;0.0604)		TTGCTGGCCACCAAACTGCAG	0.527		NA											4	66					0.00024832	0.000261054	1	0
DBC1	1620	broad.mit.edu	37	9	121930223	121930223	+	Silent	SNP	G	G	A			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr9:121930223G>A	uc004bkc.2	-	8	1881	c.1425C>T	c.(1423-1425)ATC>ATT	p.I475I		NM_014618	NP_055433	O60477	DBC1_HUMAN	deleted in bladder cancer 1 precursor	475					cell cycle arrest|cell death	cytoplasm	protein binding			skin(3)|ovary(2)|central_nervous_system(2)|large_intestine(1)	8						TCTCAAAGCTGATGAACTGCT	0.572		NA											16	53					0	0	0	0
GSN	2934	broad.mit.edu	37	9	124072998	124072998	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr9:124072998C>T	uc004blf.1	+	4	602	c.541C>T	c.(541-543)CCC>TCC	p.P181S	GSN_uc004bld.1_Missense_Mutation_p.P130S|GSN_uc010mvq.1_Missense_Mutation_p.P141S|GSN_uc010mvr.1_Missense_Mutation_p.P141S|GSN_uc010mvu.1_Missense_Mutation_p.P130S|GSN_uc010mvt.1_Missense_Mutation_p.P130S|GSN_uc010mvs.1_Missense_Mutation_p.P130S|GSN_uc004ble.1_Missense_Mutation_p.P130S|GSN_uc010mvv.1_Missense_Mutation_p.P130S|GSN_uc011lyh.1_Missense_Mutation_p.P147S|GSN_uc011lyi.1_Missense_Mutation_p.P130S|GSN_uc011lyj.1_Missense_Mutation_p.P154S|GSN_uc004blg.1_5'Flank	NM_000177	NP_000168	P06396	GELS_HUMAN	gelsolin isoform a precursor	181					actin filament polymerization|actin filament severing|barbed-end actin filament capping|cellular component disassembly involved in apoptosis|cilium morphogenesis	actin cytoskeleton|cytosol	actin binding|calcium ion binding|protein binding			breast(2)|ovary(1)	3						GCACGTGGTACCCAACGAGGT	0.577		NA											18	74					0	0	0	0
GOLGA1	2800	broad.mit.edu	37	9	127684082	127684082	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr9:127684082C>T	uc004bpc.2	-	9	993	c.651G>A	c.(649-651)ATG>ATA	p.M217I	GOLGA1_uc010mws.2_RNA|GOLGA1_uc010mwt.1_Missense_Mutation_p.M192I	NM_002077	NP_002068	Q92805	GOGA1_HUMAN	golgin 97	217	Potential.					Golgi cisterna membrane				ovary(1)	1						GATTGGAGTTCATCAACTCCT	0.438		NA											54	213					0	0	0	0
NUP188	23511	broad.mit.edu	37	9	131745261	131745261	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr9:131745261G>C	uc004bws.1	+	17	1772	c.1750G>C	c.(1750-1752)GAC>CAC	p.D584H	NUP188_uc004bwu.2_5'Flank	NM_015354	NP_056169	Q5SRE5	NU188_HUMAN	nucleoporin 188kDa	584					carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear pore	protein binding			ovary(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)|kidney(1)|breast(1)	7						GTCGATAGCAGACTGTCTCCT	0.522		NA											50	186					0	0	0	0
MED14	9282	broad.mit.edu	37	X	40522377	40522377	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chrX:40522377G>A	uc004dex.3	-	26	3624	c.3484C>T	c.(3484-3486)CGT>TGT	p.R1162C	MED14_uc004dey.1_Missense_Mutation_p.R64C	NM_004229	NP_004220	O60244	MED14_HUMAN	mediator complex subunit 14	1162	Pro-rich.				androgen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			breast(2)|kidney(1)|skin(1)	4						GGTAGTTTACGAGGTGGAGGC	0.453		NA											10	10					0	0	0	0
GDPD2	54857	broad.mit.edu	37	X	69649354	69649354	+	Silent	SNP	C	C	T			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chrX:69649354C>T	uc004dyh.2	+	11	1199	c.948C>T	c.(946-948)TTC>TTT	p.F316F	GDPD2_uc010nkx.1_3'UTR|GDPD2_uc010nky.1_Silent_p.F102F|GDPD2_uc011mpk.1_Silent_p.F316F|GDPD2_uc011mpl.1_Silent_p.F237F|GDPD2_uc011mpm.1_Silent_p.F237F	NM_017711	NP_060181	Q9HCC8	GDPD2_HUMAN	osteoblast differentiation promoting factor	316	GDPD.|Extracellular (Potential).				glycerol metabolic process|lipid metabolic process	cytoplasm|cytoskeleton|integral to membrane|plasma membrane	glycerophosphodiester phosphodiesterase activity|glycerophosphoinositol inositolphosphodiesterase activity|metal ion binding			ovary(2)	2	Renal(35;0.156)					GGCGACCCTTCTGGGGGGCCA	0.522		NA											12	16					0	0	0	0
DRP2	1821	broad.mit.edu	37	X	100511136	100511136	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chrX:100511136C>G	uc004egz.2	+	21	2645	c.2276C>G	c.(2275-2277)TCC>TGC	p.S759C	DRP2_uc011mrh.1_Missense_Mutation_p.S681C	NM_001939	NP_001930	Q13474	DRP2_HUMAN	dystrophin related protein 2	759					central nervous system development	cytoplasm|cytoskeleton	zinc ion binding			ovary(2)	2						CTGCGGCACTCCAGCCCCATC	0.572		NA											26	58					0	0	0	0
USH2A	7399	broad.mit.edu	37	1	215848871	215848872	+	Frame_Shift_Del	DEL	AG	AG	-			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr1:215848871_215848872delAG	uc001hku.1	-	63	12768_12769	c.12381_12382delCT	c.(12379-12384)CTCTACfs	p.L4127fs		NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	4127_4128	Fibronectin type-III 26.|Extracellular (Potential).				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		GTCAGTGTGTAGAGAGTGAAAG	0.559		NA								HNSCC(13;0.011)			15	41	---	---	---	---	NA	NA	NA	NA
ZNF319	57567	broad.mit.edu	37	16	58031982	58031982	+	Frame_Shift_Del	DEL	G	G	-			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr16:58031982delG	uc002emx.1	-	2	811	c.188delC	c.(187-189)CCAfs	p.P63fs		NM_020807	NP_065858	Q9P2F9	ZN319_HUMAN	zinc finger protein 319	63	Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						TGCGTGTTGTGGGGGCTGCAG	0.687		NA											20	62	---	---	---	---	NA	NA	NA	NA
BIRC6	57448	broad.mit.edu	37	2	32641134	32641153	+	Frame_Shift_Del	DEL	AGTGGAGCCTCCCAAAAAGG	AGTGGAGCCTCCCAAAAAGG	-			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr2:32641134_32641153delAGTGGAGCCTCCCAAAAAGG	uc010ezu.2	+	10	2909_2928	c.2775_2794delAGTGGAGCCTCCCAAAAAGG	c.(2773-2796)AAAGTGGAGCCTCCCAAAAAGGAGfs	p.K925fs		NM_016252	NP_057336	Q9NR09	BIRC6_HUMAN	baculoviral IAP repeat-containing 6	925_932					anti-apoptosis|apoptosis	intracellular	acid-amino acid ligase activity|cysteine-type endopeptidase inhibitor activity|protein binding			ovary(5)|skin(4)|lung(2)|central_nervous_system(1)|breast(1)|pancreas(1)	14	Acute lymphoblastic leukemia(172;0.155)					TTTTGGCCAAAGTGGAGCCTCCCAAAAAGGAGGGCACTGA	0.414		NA											18	140	---	---	---	---	NA	NA	NA	NA
TCF7	6932	broad.mit.edu	37	5	133473764	133473765	+	Frame_Shift_Ins	INS	-	-	C			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr5:133473764_133473765insC	uc003kyt.2	+	4	652_653	c.456_457insC	c.(454-459)CAGCCCfs	p.Q152fs	TCF7_uc003kyu.1_Frame_Shift_Ins_p.Q37fs|TCF7_uc003kyv.2_Frame_Shift_Ins_p.Q37fs|TCF7_uc003kyw.2_Frame_Shift_Ins_p.Q37fs|TCF7_uc003kyx.2_5'UTR|TCF7_uc003kyy.2_Frame_Shift_Ins_p.Q37fs|TCF7_uc003kyz.2_Frame_Shift_Ins_p.Q37fs|TCF7_uc003kza.2_Frame_Shift_Ins_p.Q37fs	NM_003202	NP_003193	P36402	TCF7_HUMAN	transcription factor 7 (T-cell specific,	152_153					cellular response to interleukin-4|immune response|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent|Wnt receptor signaling pathway	nucleus	protein binding|transcription regulatory region DNA binding				0		Breast(839;0.058)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			AGGCCAATCAGCCCCCCCACGG	0.574		NA											14	113	---	---	---	---	NA	NA	NA	NA