Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	isArtifactMode	oxoGCut
ATAD3B	83858	broad.mit.edu	37	1	1430870	1430870	+	Silent	SNP	G	G	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr1:1430870G>A	uc001afv.2	+	16	1721	c.1620G>A	c.(1618-1620)ACG>ACA	p.T540T	ATAD3B_uc001afx.2_Silent_p.T494T|ATAD3B_uc001afy.2_Silent_p.T93T	NM_031921	NP_114127	Q5T9A4	ATD3B_HUMAN	AAA-ATPase  TOB3	540							ATP binding|nucleoside-triphosphatase activity				0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;1.79e-36)|OV - Ovarian serous cystadenocarcinoma(86;3.94e-22)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.00461)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.145)		ACTAGGCCACGGCATATGCCT	0.632		NA											23	15					0	0	0	0
SLC35E2	9906	broad.mit.edu	37	1	1670363	1670363	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr1:1670363C>T	uc001aib.1	-	3	872	c.456G>A	c.(454-456)ATG>ATA	p.M152I	SLC35E2B_uc001ahh.3_Intron|SLC35E2_uc009vkm.1_Missense_Mutation_p.M152I|SLC35E2_uc001ahy.2_Missense_Mutation_p.M152I|SLC35E2_uc001ahz.2_Missense_Mutation_p.M152I	NM_182838	NP_878258	P0CK97	S35E2_HUMAN	solute carrier family 35, member E2	152	Helical; (Potential).					integral to membrane				pancreas(1)	1	all_cancers(77;0.000708)|all_epithelial(69;0.000943)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;5.61e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;5.26e-37)|OV - Ovarian serous cystadenocarcinoma(86;2.54e-23)|GBM - Glioblastoma multiforme(42;9e-08)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00227)|STAD - Stomach adenocarcinoma(132;0.00644)|BRCA - Breast invasive adenocarcinoma(365;0.00786)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.199)		TTCTTTACCTCATCAGACCCA	0.473		NA											8	28					0	0	0	0
AJAP1	55966	broad.mit.edu	37	1	4772252	4772252	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr1:4772252G>C	uc001alm.1	+	2	703	c.322G>C	c.(322-324)GCG>CCG	p.A108P	AJAP1_uc001aln.2_Missense_Mutation_p.A108P	NM_001042478	NP_001035943	Q9UKB5	AJAP1_HUMAN	adherens junction associated protein 1	108	Extracellular (Potential).				cell adhesion	adherens junction|apical plasma membrane|basolateral plasma membrane|integral to membrane				lung(1)	1	all_cancers(77;0.071)|Ovarian(185;0.0721)	all_cancers(23;1.77e-36)|all_epithelial(116;1.26e-21)|all_lung(118;3.51e-08)|Lung NSC(185;3.47e-06)|all_neural(13;8.84e-06)|all_hematologic(16;7.61e-05)|Breast(487;0.000507)|Renal(390;0.0007)|Colorectal(325;0.00117)|Hepatocellular(190;0.0071)|Glioma(11;0.0155)|Myeloproliferative disorder(586;0.0258)|Ovarian(437;0.0409)|Lung SC(97;0.133)|Medulloblastoma(700;0.215)		Epithelial(90;3.89e-35)|OV - Ovarian serous cystadenocarcinoma(86;1.97e-19)|GBM - Glioblastoma multiforme(42;3.71e-19)|Colorectal(212;4.57e-06)|COAD - Colon adenocarcinoma(227;0.00019)|Kidney(185;0.000969)|BRCA - Breast invasive adenocarcinoma(365;0.00122)|STAD - Stomach adenocarcinoma(132;0.00578)|KIRC - Kidney renal clear cell carcinoma(229;0.0126)|READ - Rectum adenocarcinoma(331;0.0689)		CCGGGACCAGGCGGCCGCCCT	0.736		NA											2	7					0	0	0	0
CAMTA1	23261	broad.mit.edu	37	1	7723703	7723703	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr1:7723703C>A	uc001aoi.2	+	9	1303	c.1096C>A	c.(1096-1098)CTC>ATC	p.L366I		NM_015215	NP_056030	Q9Y6Y1	CMTA1_HUMAN	calmodulin-binding transcription activator 1	366					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	calmodulin binding			ovary(5)|central_nervous_system(2)|breast(1)|pancreas(1)	9	Ovarian(185;0.0634)	all_epithelial(116;8.38e-23)|all_lung(118;5.87e-07)|Lung NSC(185;3.43e-06)|Renal(390;0.000219)|Breast(487;0.000307)|Colorectal(325;0.000615)|Hepatocellular(190;0.0088)|Myeloproliferative disorder(586;0.0303)|Ovarian(437;0.0388)		UCEC - Uterine corpus endometrioid carcinoma (279;0.101)|Colorectal(212;1.33e-05)|COAD - Colon adenocarcinoma(227;0.000235)|BRCA - Breast invasive adenocarcinoma(304;0.000864)|Kidney(185;0.00244)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0179)|READ - Rectum adenocarcinoma(331;0.133)		CAGCAGCGGGCTCAACAGCGA	0.662		NA											33	60					1.04e-10	1.32e-10	1	0
KIAA2013	90231	broad.mit.edu	37	1	11982754	11982754	+	Missense_Mutation	SNP	A	A	C			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr1:11982754A>C	uc001atk.2	-	2	2020	c.1826T>G	c.(1825-1827)CTC>CGC	p.L609R	KIAA2013_uc001atl.1_Missense_Mutation_p.L609R	NM_138346	NP_612355	Q8IYS2	K2013_HUMAN	hypothetical protein LOC90231 precursor	609	Helical; (Potential).					integral to membrane				ovary(1)	1	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00149)|all_lung(284;0.00189)|Breast(348;0.00586)|Colorectal(325;0.0062)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0556)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;4.88e-06)|COAD - Colon adenocarcinoma(227;0.000241)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|Kidney(185;0.000722)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		GAGCTTGAAGAGGAAGAGGTG	0.597		NA											10	20					0	0	0	0
PRAMEF1	65121	broad.mit.edu	37	1	12854287	12854287	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr1:12854287G>A	uc001auj.1	+	3	614	c.511G>A	c.(511-513)GTT>ATT	p.V171I		NM_023013	NP_075389	O95521	PRAM1_HUMAN	PRAME family member 1	171											0	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.0042)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;4.88e-06)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|COAD - Colon adenocarcinoma(227;0.000241)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		CTTCCAGTGGGTTTACCAAAG	0.433		NA											83	283					0	0	0	0
PRAMEF4	400735	broad.mit.edu	37	1	12939515	12939515	+	Nonsense_Mutation	SNP	G	G	T			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr1:12939515G>T	uc001aun.2	-	4	1358	c.1287C>A	c.(1285-1287)TGC>TGA	p.C429*		NM_001009611	NP_001009611	O60810	PRAM4_HUMAN	PRAME family member 4	429										ovary(1)	1	Ovarian(185;0.249)	Lung NSC(185;3.67e-05)|all_lung(284;4.03e-05)|Renal(390;0.000147)|Breast(348;0.000278)|Colorectal(325;0.00058)|Ovarian(437;0.00965)|Hepatocellular(190;0.0245)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;4.88e-06)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|COAD - Colon adenocarcinoma(227;0.000241)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		ATCTGCTCCAGCAGAGAGTAC	0.512		NA											97	173					1.1e-53	1.62e-53	1	0
CLCNKB	1188	broad.mit.edu	37	1	16378026	16378026	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr1:16378026G>T	uc001axw.3	+	13	1361	c.1281G>T	c.(1279-1281)ATG>ATT	p.M427I	FAM131C_uc010obz.1_Intron|CLCNKB_uc001axx.3_Missense_Mutation_p.M427I|CLCNKB_uc001axy.3_Missense_Mutation_p.M258I	NM_000085	NP_000076	P51801	CLCKB_HUMAN	chloride channel Kb isoform 1	427	Helical; (Potential).				excretion	chloride channel complex|integral to plasma membrane	voltage-gated chloride channel activity			skin(1)	1		Colorectal(325;3.46e-05)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Colorectal(212;8.04e-08)|COAD - Colon adenocarcinoma(227;5.46e-06)|BRCA - Breast invasive adenocarcinoma(304;9.02e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(313;0.00655)|READ - Rectum adenocarcinoma(331;0.0649)		GGTACTTCATGCCCATCTTTG	0.592		NA											48	104					1.65e-34	2.41e-34	1	0
CAPZB	832	broad.mit.edu	37	1	19671737	19671737	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr1:19671737C>G	uc010ocz.1	-	7	1113	c.685G>C	c.(685-687)GAT>CAT	p.D229H	CAPZB_uc001bce.2_Missense_Mutation_p.D200H|CAPZB_uc009vpk.2_Missense_Mutation_p.D226H|CAPZB_uc001bcd.2_Missense_Mutation_p.D188H	NM_004930	NP_004921	P47756	CAPZB_HUMAN	F-actin capping protein beta subunit	200					actin cytoskeleton organization|actin filament capping|blood coagulation|cellular component movement	cytosol|F-actin capping protein complex|WASH complex	actin binding				0		Colorectal(325;3.93e-05)|Renal(390;0.000147)|all_lung(284;0.000169)|Lung NSC(340;0.000202)|Breast(348;0.000496)|Ovarian(437;0.00428)|Myeloproliferative disorder(586;0.0262)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Kidney(64;8.63e-06)|BRCA - Breast invasive adenocarcinoma(304;4.06e-05)|KIRC - Kidney renal clear cell carcinoma(64;0.000175)|GBM - Glioblastoma multiforme(114;0.000525)|STAD - Stomach adenocarcinoma(196;0.00779)|READ - Rectum adenocarcinoma(331;0.103)|Lung(427;0.173)		ACAGTTTCATCCTTCTCCATC	0.557		NA											4	110					0	0	0	0
CNKSR1	10256	broad.mit.edu	37	1	26510929	26510929	+	Silent	SNP	C	C	T			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr1:26510929C>T	uc001bln.3	+	12	1117	c.1059C>T	c.(1057-1059)CCC>CCT	p.P353P	CNKSR1_uc010oex.1_RNA|CNKSR1_uc001blm.3_Silent_p.P346P|CNKSR1_uc009vsd.2_Silent_p.P88P|CNKSR1_uc009vse.2_Silent_p.P88P|CNKSR1_uc001blo.2_Silent_p.P88P	NM_006314	NP_006305	Q969H4	CNKR1_HUMAN	connector enhancer of kinase suppressor of Ras	353	Pro-rich.				Rho protein signal transduction|transmembrane receptor protein tyrosine kinase signaling pathway	cell cortex|cell-cell junction	protein binding, bridging			lung(1)|kidney(1)	2		Colorectal(325;3.46e-05)|all_lung(284;0.000116)|Lung NSC(340;0.000154)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0133)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0298)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;2.72e-26)|Colorectal(126;1.24e-08)|COAD - Colon adenocarcinoma(152;9.31e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00072)|BRCA - Breast invasive adenocarcinoma(304;0.000959)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.00823)|READ - Rectum adenocarcinoma(331;0.0649)		TGCCCATCCCCCCGGAACCCC	0.637		NA											13	17					0	0	0	0
MATN1	4146	broad.mit.edu	37	1	31187158	31187158	+	Silent	SNP	G	G	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr1:31187158G>A	uc001brz.2	-	7	1411	c.1377C>T	c.(1375-1377)GCC>GCT	p.A459A	MATN1_uc001bsa.1_Silent_p.A377A	NM_002379	NP_002370	P21941	MATN1_HUMAN	matrilin 1, cartilage matrix protein precursor	459					protein complex assembly	proteinaceous extracellular matrix	extracellular matrix structural constituent|protein binding			central_nervous_system(1)	1		Colorectal(325;0.00792)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)|Ovarian(437;0.0563)|Breast(348;0.0848)|Medulloblastoma(700;0.123)		Colorectal(126;1.29e-05)|COAD - Colon adenocarcinoma(152;0.000726)|STAD - Stomach adenocarcinoma(196;0.0183)|READ - Rectum adenocarcinoma(331;0.0649)		GGGACTCGCAGGCACACGGGT	0.627		NA											4	13					0	0	0	0
SPOCD1	90853	broad.mit.edu	37	1	32267266	32267266	+	Missense_Mutation	SNP	T	T	C			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr1:32267266T>C	uc001bts.1	-	3	1482	c.1424A>G	c.(1423-1425)TAC>TGC	p.Y475C	SPOCD1_uc001btt.2_5'Flank|SPOCD1_uc001btu.2_Missense_Mutation_p.Y475C|SPOCD1_uc001btv.2_5'UTR	NM_144569	NP_653170	Q6ZMY3	SPOC1_HUMAN	SPOC domain containing 1	475					transcription, DNA-dependent					ovary(5)|breast(1)	6		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.186)|Ovarian(437;0.199)		STAD - Stomach adenocarcinoma(196;0.18)		AAAACCTACGTAGCACACAAG	0.507		NA											22	57					0	0	0	0
TIE1	7075	broad.mit.edu	37	1	43772569	43772569	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr1:43772569G>C	uc001ciu.2	+	4	622	c.543G>C	c.(541-543)CAG>CAC	p.Q181H	TIE1_uc010okd.1_Missense_Mutation_p.Q181H|TIE1_uc010oke.1_Missense_Mutation_p.Q136H|TIE1_uc009vwq.2_Missense_Mutation_p.Q181H|TIE1_uc010okf.1_5'UTR|TIE1_uc010okg.1_5'Flank|TIE1_uc010okb.1_Missense_Mutation_p.Q181H|TIE1_uc010okc.1_Missense_Mutation_p.Q181H	NM_005424	NP_005415	P35590	TIE1_HUMAN	tyrosine kinase with immunoglobulin-like and	181	Extracellular (Potential).				mesoderm development	integral to plasma membrane	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity			lung(3)|stomach(1)|salivary_gland(1)|ovary(1)|skin(1)	7	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				TCCTGCTGCAGCTCCCAAATG	0.607		NA											18	46					0	0	0	0
CC2D1B	200014	broad.mit.edu	37	1	52826198	52826198	+	Silent	SNP	G	G	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr1:52826198G>A	uc001ctq.1	-	6	639	c.501C>T	c.(499-501)CAC>CAT	p.H167H	CC2D1B_uc001ctr.2_5'Flank|CC2D1B_uc001cts.2_5'Flank	NM_032449	NP_115825	Q5T0F9	C2D1B_HUMAN	coiled-coil and C2 domain containing 1B	167	Potential.									ovary(2)	2						CCAGCAAAGCGTGTAGCCCCT	0.632		NA											11	23					0	0	0	0
LRRC7	57554	broad.mit.edu	37	1	70300502	70300502	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr1:70300502G>T	uc001dep.2	+	4	456	c.426G>T	c.(424-426)CAG>CAT	p.Q142H	LRRC7_uc001deo.1_Missense_Mutation_p.Q180H|LRRC7_uc009wbg.2_5'UTR	NM_020794	NP_065845	Q96NW7	LRRC7_HUMAN	leucine rich repeat containing 7	142	LRR 6.					centrosome|focal adhesion|nucleolus	protein binding			ovary(9)|breast(2)|central_nervous_system(2)|liver(1)	14						ACCTGACCCAGCTCTACCTGA	0.358		NA											23	47					6.21e-17	8.51e-17	1	0
C1orf173	127254	broad.mit.edu	37	1	75097586	75097586	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr1:75097586C>A	uc001dgg.2	-	7	849	c.630G>T	c.(628-630)AGG>AGT	p.R210S	C1orf173_uc001dgi.3_Missense_Mutation_p.R4S	NM_001002912	NP_001002912	Q5RHP9	CA173_HUMAN	hypothetical protein LOC127254	210										ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	5						CTATGGAGTTCCTGAACTTCA	0.393		NA											39	51					1.47e-24	2.1e-24	1	0
FAM73A	374986	broad.mit.edu	37	1	78332059	78332059	+	Nonsense_Mutation	SNP	A	A	T			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr1:78332059A>T	uc001dhx.2	+	14	1578	c.1546A>T	c.(1546-1548)AAA>TAA	p.K516*	FAM73A_uc010ork.1_Nonsense_Mutation_p.K516*|FAM73A_uc010orl.1_Nonsense_Mutation_p.K478*	NM_198549	NP_940951	Q8NAN2	FA73A_HUMAN	hypothetical protein LOC374986	516						integral to membrane				ovary(1)	1				Colorectal(170;0.226)		GCTGAAACAGAAAAGACAACA	0.353		NA											28	69					0	0	0	0
LPHN2	23266	broad.mit.edu	37	1	82416749	82416749	+	Missense_Mutation	SNP	A	A	G			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr1:82416749A>G	uc001dit.3	+	8	1721	c.1540A>G	c.(1540-1542)AAG>GAG	p.K514E	LPHN2_uc001dis.2_Intron|LPHN2_uc001diu.2_Missense_Mutation_p.K514E|LPHN2_uc001div.2_Missense_Mutation_p.K514E|LPHN2_uc009wcd.2_Missense_Mutation_p.K514E|LPHN2_uc001diw.2_Missense_Mutation_p.K85E	NM_012302	NP_036434	O95490	LPHN2_HUMAN	latrophilin 2 precursor	514	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|latrotoxin receptor activity|sugar binding			ovary(3)|lung(3)|breast(2)|central_nervous_system(1)	9				all cancers(265;0.00142)|Epithelial(280;0.00829)|OV - Ovarian serous cystadenocarcinoma(397;0.077)|STAD - Stomach adenocarcinoma(256;0.248)		ATGGAACCCTAAGGGCCCCGA	0.438		NA											29	67					0	0	0	0
CLCA1	1179	broad.mit.edu	37	1	86961284	86961284	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr1:86961284G>A	uc001dlt.2	+	12	2168	c.2039G>A	c.(2038-2040)GGA>GAA	p.G680E		NM_001285	NP_001276	A8K7I4	CLCA1_HUMAN	chloride channel accessory 1 precursor	680					calcium ion transport	extracellular space|integral to plasma membrane	chloride channel activity			ovary(1)	1		Lung NSC(277;0.239)		all cancers(265;0.0249)|Epithelial(280;0.0476)		GCTCTGGGAGGAGTTAACGCA	0.463		NA											22	40					0	0	0	0
EVI5	7813	broad.mit.edu	37	1	93167773	93167773	+	Splice_Site	SNP	C	C	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr1:93167773C>A	uc001dox.2	-	5	707	c.697_splice	c.e5-1	p.A233_splice	EVI5_uc010otf.1_Splice_Site_p.A233_splice	NM_005665	NP_005656	O60447	EVI5_HUMAN	ecotropic viral integration site 5						cell cycle|cell division|cell proliferation|multicellular organismal development	microtubule organizing center|nucleus|spindle	protein binding|Rab GTPase activator activity			ovary(1)|breast(1)	2		all_lung(203;0.00146)|Lung NSC(277;0.00565)|all_neural(321;0.185)|Melanoma(281;0.193)|Glioma(108;0.203)		Epithelial(280;8.09e-25)|OV - Ovarian serous cystadenocarcinoma(397;1.27e-22)|all cancers(265;1.74e-21)|GBM - Glioblastoma multiforme(16;0.00233)|BRCA - Breast invasive adenocarcinoma(282;0.211)		AAGAGTAAGCCTAAAAAGTAA	0.303		NA											15	21					1.05e-09	1.31e-09	1	0
GNAI3	2773	broad.mit.edu	37	1	110129355	110129355	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr1:110129355G>A	uc001dxz.2	+	7	882	c.725G>A	c.(724-726)CGA>CAA	p.R242Q		NM_006496	NP_006487	P08754	GNAI3_HUMAN	guanine nucleotide binding protein (G protein),	242					cell cycle|cell division|inhibition of adenylate cyclase activity by G-protein signaling pathway|platelet activation|synaptic transmission	centrosome|heterotrimeric G-protein complex|midbody	G-protein beta/gamma-subunit complex binding|GTP binding|GTPase activity|metabotropic serotonin receptor binding|signal transducer activity			ovary(1)	1		all_epithelial(167;2.5e-05)|all_lung(203;0.000135)|Lung NSC(277;0.000269)|Breast(1374;0.244)		Lung(183;0.046)|Colorectal(144;0.119)|Epithelial(280;0.139)|all cancers(265;0.147)|LUSC - Lung squamous cell carcinoma(189;0.237)		TTTCAGAACCGAATGCATGAA	0.318		NA											16	26					0	0	0	0
WARS2	10352	broad.mit.edu	37	1	119575893	119575893	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr1:119575893C>A	uc001ehn.2	-	6	752	c.724G>T	c.(724-726)GAC>TAC	p.D242Y	WARS2_uc010oxf.1_Missense_Mutation_p.D148Y|WARS2_uc001ehm.2_3'UTR|WARS2_uc010oxg.1_Missense_Mutation_p.D185Y|WARS2_uc010oxh.1_3'UTR	NM_015836	NP_056651	Q9UGM6	SYWM_HUMAN	mitochondrial tryptophanyl tRNA synthetase 2	242					tryptophanyl-tRNA aminoacylation	mitochondrial matrix	ATP binding|tryptophan-tRNA ligase activity				0	all_neural(166;0.187)	all_lung(203;2.48e-06)|Lung NSC(69;1.74e-05)|all_epithelial(167;0.000564)		Lung(183;0.0629)	L-Tryptophan(DB00150)	TCTGGGCTGTCTGTTATTCGG	0.517		NA											50	91					4.01e-20	5.57e-20	1	0
SNX27	81609	broad.mit.edu	37	1	151611499	151611499	+	Silent	SNP	G	G	T			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr1:151611499G>T	uc001eyn.1	+	2	463	c.447G>T	c.(445-447)TCG>TCT	p.S149S	SNX27_uc001eyo.2_Silent_p.S56S|SNX27_uc001eyp.2_5'UTR	NM_030918	NP_112180	Q96L92	SNX27_HUMAN	sorting nexin family member 27	149					cell communication|protein transport|signal transduction	cytosol|early endosome	phosphatidylinositol binding|protein binding			ovary(2)|central_nervous_system(1)	3	Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		LUSC - Lung squamous cell carcinoma(543;0.181)			GTGACGACTCGTTGGGACAAT	0.468		NA											25	53					1.64e-13	2.17e-13	1	0
LINGO4	339398	broad.mit.edu	37	1	151774763	151774763	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr1:151774763G>A	uc001ezf.1	-	2	608	c.418C>T	c.(418-420)CGC>TGC	p.R140C		NM_001004432	NP_001004432	Q6UY18	LIGO4_HUMAN	leucine rich repeat and Ig domain containing 4	140	Extracellular (Potential).|LRR 4.					integral to membrane				large_intestine(1)	1	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.14)		LUSC - Lung squamous cell carcinoma(543;0.181)			TGGTTGAGGCGGAGGTCCAGC	0.582		NA											35	69					0	0	0	0
FLG	2312	broad.mit.edu	37	1	152284331	152284331	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr1:152284331C>G	uc001ezu.1	-	3	3067	c.3031G>C	c.(3031-3033)GAG>CAG	p.E1011Q	uc001ezv.2_5'Flank	NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	1011	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GAGGAAGTCTCTGCGTGAGGA	0.582		NA							Ichthyosis				138	260					0	0	0	0
OR10T2	128360	broad.mit.edu	37	1	158369186	158369186	+	Missense_Mutation	SNP	A	A	T			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr1:158369186A>T	uc010pih.1	-	1	71	c.71T>A	c.(70-72)CTC>CAC	p.L24H		NM_001004475	NP_001004475	Q8NGX3	O10T2_HUMAN	olfactory receptor, family 10, subfamily T,	24	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|central_nervous_system(1)	3	all_hematologic(112;0.0378)					CAGCAGCTGGAGCTCCCCCAG	0.483		NA											11	29					0	0	0	0
IGSF9	57549	broad.mit.edu	37	1	159898079	159898079	+	Silent	SNP	G	G	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr1:159898079G>A	uc001fur.2	-	19	3297	c.3099C>T	c.(3097-3099)TTC>TTT	p.F1033F	IGSF9_uc001fuq.2_Silent_p.F1017F|CCDC19_uc001ful.2_5'Flank|TAGLN2_uc001fun.1_5'Flank|TAGLN2_uc001fuo.1_5'Flank|TAGLN2_uc010piy.1_5'Flank|IGSF9_uc001fup.2_Silent_p.F179F	NM_001135050	NP_001128522	Q9P2J2	TUTLA_HUMAN	immunoglobulin superfamily, member 9 isoform a	1033	Cytoplasmic (Potential).					cell junction|integral to membrane|synapse				ovary(2)|central_nervous_system(2)|large_intestine(1)	5	all_hematologic(112;0.0597)	Breast(1374;0.000126)	BRCA - Breast invasive adenocarcinoma(70;0.111)			GGGGCCGCAGGAACGAAGCGC	0.697		NA											13	17					0	0	0	0
FCGR3B	2215	broad.mit.edu	37	1	161599754	161599754	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr1:161599754G>C	uc009wul.2	-	3	407	c.133C>G	c.(133-135)CTG>GTG	p.L45V		NM_000570	NP_000561	O75015	FCG3B_HUMAN	low affinity immunoglobulin gamma Fc region	45	Ig-like C2-type 1.				immune response	anchored to membrane|extracellular region|plasma membrane	IgG binding|receptor activity				0	all_cancers(52;4.89e-16)|all_hematologic(112;0.0207)		BRCA - Breast invasive adenocarcinoma(70;0.00376)		Abciximab(DB00054)|Adalimumab(DB00051)|Alefacept(DB00092)|Alemtuzumab(DB00087)|Basiliximab(DB00074)|Bevacizumab(DB00112)|Cetuximab(DB00002)|Daclizumab(DB00111)|Efalizumab(DB00095)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Natalizumab(DB00108)|Palivizumab(DB00110)|Rituximab(DB00073)|Tositumomab(DB00081)|Trastuzumab(DB00072)	TGGCACTTCAGAGTCACACTG	0.532		NA											24	74					0	0	0	0
PRRX1	5396	broad.mit.edu	37	1	170633413	170633413	+	Silent	SNP	C	C	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr1:170633413C>A	uc001ghf.2	+	1	101	c.54C>A	c.(52-54)CGC>CGA	p.R18R	PRRX1_uc001ghe.2_Silent_p.R18R	NM_022716	NP_073207	P54821	PRRX1_HUMAN	paired mesoderm homeobox 1 isoform pmx-1b	18						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			ovary(1)	1	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					TGGGCGGCCGCTTGGACAGCC	0.662		NA											14	19					6.32e-08	7.58e-08	1	0
TNN	63923	broad.mit.edu	37	1	175092651	175092651	+	Silent	SNP	T	T	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr1:175092651T>A	uc001gkl.1	+	12	2879	c.2766T>A	c.(2764-2766)GCT>GCA	p.A922A		NM_022093	NP_071376	Q9UQP3	TENN_HUMAN	tenascin N precursor	922	Fibronectin type-III 8.				cell growth|cell migration|signal transduction	extracellular space|proteinaceous extracellular matrix				large_intestine(5)|ovary(3)|central_nervous_system(1)	9		Breast(1374;0.000962)		KIRC - Kidney renal clear cell carcinoma(1967;0.00198)		ACACCTCTGCTGACGGAGAGA	0.597		NA											17	59					0	0	0	0
PAPPA2	60676	broad.mit.edu	37	1	176526361	176526361	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr1:176526361C>A	uc001gkz.2	+	2	2067	c.903C>A	c.(901-903)AAC>AAA	p.N301K	PAPPA2_uc001gky.1_Missense_Mutation_p.N301K|PAPPA2_uc009www.2_RNA	NM_020318	NP_064714	Q9BXP8	PAPP2_HUMAN	pappalysin 2 isoform 1	301					cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			ovary(7)|central_nervous_system(5)|skin(2)|lung(1)|breast(1)	16						GACAGAACAACCCAGCCATCA	0.577		NA											4	13					0.000602214	0.000648391	1	0
F13B	2165	broad.mit.edu	37	1	197030098	197030098	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr1:197030098C>A	uc001gtt.1	-	4	603	c.559G>T	c.(559-561)GCT>TCT	p.A187S		NM_001994	NP_001985	P05160	F13B_HUMAN	coagulation factor XIII B subunit precursor	187	Sushi 3.				blood coagulation	extracellular region				upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	3						TTTCCTCCAGCTGTGTAGTAG	0.388		NA											30	84					3.17e-13	4.17e-13	1	0
PTPRC	5788	broad.mit.edu	37	1	198687375	198687375	+	Missense_Mutation	SNP	A	A	G			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr1:198687375A>G	uc001gur.1	+	14	1777	c.1597A>G	c.(1597-1599)AAG>GAG	p.K533E	PTPRC_uc001gus.1_Missense_Mutation_p.K485E|PTPRC_uc001gut.1_Missense_Mutation_p.K372E|PTPRC_uc009wzf.1_Missense_Mutation_p.K421E|PTPRC_uc010ppg.1_Missense_Mutation_p.K469E	NM_002838	NP_002829	P08575	PTPRC_HUMAN	protein tyrosine phosphatase, receptor type, C	533	Extracellular (Potential).|Fibronectin type-III 2.				axon guidance|B cell proliferation|B cell receptor signaling pathway|defense response to virus|immunoglobulin biosynthetic process|negative regulation of cytokine-mediated signaling pathway|negative regulation of protein kinase activity|negative regulation of T cell mediated cytotoxicity|positive regulation of antigen receptor-mediated signaling pathway|positive regulation of B cell proliferation|positive regulation of protein kinase activity|positive regulation of T cell proliferation|regulation of S phase|release of sequestered calcium ion into cytosol|T cell differentiation|T cell receptor signaling pathway	focal adhesion|integral to plasma membrane|membrane raft	protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			breast(4)|skin(3)|ovary(2)|lung(1)|kidney(1)|pancreas(1)	12						TGAGTCGCATAAGAATTGCGA	0.398		NA											12	22					0	0	0	0
KIF21B	23046	broad.mit.edu	37	1	200954076	200954076	+	Silent	SNP	G	G	C			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr1:200954076G>C	uc001gvs.1	-	27	4031	c.3714C>G	c.(3712-3714)CCC>CCG	p.P1238P	KIF21B_uc001gvr.1_Silent_p.P1238P|KIF21B_uc009wzl.1_Silent_p.P1238P|KIF21B_uc010ppn.1_Silent_p.P1238P	NM_017596	NP_060066	O75037	KI21B_HUMAN	kinesin family member 21B	1238					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(3)|skin(3)	6						GGGATGATGGGGGTGTGAATC	0.612		NA											14	52					0	0	0	0
AVPR1B	553	broad.mit.edu	37	1	206224591	206224591	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr1:206224591G>C	uc001hds.2	+	1	309	c.151G>C	c.(151-153)GGC>CGC	p.G51R		NM_000707	NP_000698	P47901	V1BR_HUMAN	arginine vasopressin receptor 1B	51	Helical; Name=1; (Potential).				activation of phospholipase C activity|elevation of cytosolic calcium ion concentration	endosome|integral to plasma membrane	protein kinase C binding|vasopressin receptor activity			ovary(2)|large_intestine(1)	3			BRCA - Breast invasive adenocarcinoma(75;0.0312)		Desmopressin(DB00035)|Terlipressin(DB02638)|Vasopressin(DB00067)	GGCGACCGGGGGCAACCTGGC	0.682		NA											21	59					0	0	0	0
IL24	11009	broad.mit.edu	37	1	207072725	207072725	+	Nonsense_Mutation	SNP	C	C	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr1:207072725C>A	uc001hes.1	+	3	379	c.105C>A	c.(103-105)TGC>TGA	p.C35*	IL24_uc001het.1_Intron|IL24_uc001heu.1_Nonsense_Mutation_p.C36*|IL24_uc001hev.1_Intron|IL24_uc001hew.1_Nonsense_Mutation_p.C36*|IL24_uc001hex.1_Intron	NM_006850	NP_006841	Q13007	IL24_HUMAN	interleukin 24 isoform 1 precursor	35					apoptosis	extracellular space	cytokine activity				0	Breast(84;0.201)					TGCTCCCTTGCCTGGGTTTTA	0.592		NA											22	46					1.18e-14	1.58e-14	1	0
CR2	1380	broad.mit.edu	37	1	207649656	207649656	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr1:207649656G>A	uc001hfw.2	+	14	2711	c.2617G>A	c.(2617-2619)GGA>AGA	p.G873R	CR2_uc001hfv.2_Missense_Mutation_p.G932R|CR2_uc009xch.2_Intron	NM_001877	NP_001868	P20023	CR2_HUMAN	complement component (3d/Epstein Barr virus)	873	Sushi 14.|Extracellular (Potential).				complement activation, classical pathway|innate immune response	integral to membrane|plasma membrane	complement receptor activity|protein homodimerization activity			upper_aerodigestive_tract(3)|skin(3)|urinary_tract(1)|ovary(1)	8						ATTTTCTCCTGGAATGTCAAT	0.527		NA											25	76					0	0	0	0
USH2A	7399	broad.mit.edu	37	1	215901506	215901506	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr1:215901506C>G	uc001hku.1	-	61	12319	c.11932G>C	c.(11932-11934)GCT>CCT	p.A3978P		NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	3978	Fibronectin type-III 25.|Extracellular (Potential).				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		ACTGAATGAGCACTCGTGGCT	0.488		NA								HNSCC(13;0.011)			37	63					0	0	0	0
USH2A	7399	broad.mit.edu	37	1	216019335	216019335	+	Silent	SNP	A	A	T			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr1:216019335A>T	uc001hku.1	-	45	9273	c.8886T>A	c.(8884-8886)CTT>CTA	p.L2962L		NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	2962	Fibronectin type-III 16.|Extracellular (Potential).				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		AACTCCAAAAAAGTGTGTAAT	0.398		NA								HNSCC(13;0.011)			11	26					0	0	0	0
FMN2	56776	broad.mit.edu	37	1	240255689	240255689	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr1:240255689C>T	uc010pyd.1	+	1	505	c.280C>T	c.(280-282)CGC>TGC	p.R94C	FMN2_uc010pye.1_Missense_Mutation_p.R94C	NM_020066	NP_064450	Q9NZ56	FMN2_HUMAN	formin 2	94					actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			ovary(4)|pancreas(3)|skin(3)|large_intestine(1)|central_nervous_system(1)	12	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			CGGCGGCTCCCGCGAAGATGT	0.622		NA											7	14					0	0	0	0
FMN2	56776	broad.mit.edu	37	1	240601394	240601394	+	Missense_Mutation	SNP	A	A	T			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr1:240601394A>T	uc010pyd.1	+	16	5169	c.4944A>T	c.(4942-4944)AAA>AAT	p.K1648N	FMN2_uc010pye.1_Missense_Mutation_p.K1652N|FMN2_uc010pyg.1_Missense_Mutation_p.K244N	NM_020066	NP_064450	Q9NZ56	FMN2_HUMAN	formin 2	1648	FH2.				actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			ovary(4)|pancreas(3)|skin(3)|large_intestine(1)|central_nervous_system(1)	12	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			TCTTCATGAAACCAAAACTTG	0.383		NA											38	76					0	0	0	0
CEP170	9859	broad.mit.edu	37	1	243289810	243289810	+	Missense_Mutation	SNP	T	T	C			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr1:243289810T>C	uc001hzs.2	-	20	5104	c.4696A>G	c.(4696-4698)ATA>GTA	p.I1566V	CEP170_uc001hzt.2_Missense_Mutation_p.I1442V|CEP170_uc001hzu.2_Missense_Mutation_p.I1468V|CEP170_uc001hzr.2_Missense_Mutation_p.I155V|CEP170_uc001hzv.1_Intron	NM_014812	NP_055627	Q5SW79	CE170_HUMAN	centrosomal protein 170kDa isoform alpha	1566	Targeting to microtubules.|Targeting to centrosomes.					centriole|microtubule|spindle				ovary(1)|haematopoietic_and_lymphoid_tissue(1)	2	all_neural(11;0.101)	all_cancers(173;0.003)	all cancers(7;5.81e-06)|GBM - Glioblastoma multiforme(7;0.000443)|OV - Ovarian serous cystadenocarcinoma(106;0.0101)			TTGAAATGTATACTGAAATCA	0.438		NA											9	16					0	0	0	0
OR11L1	391189	broad.mit.edu	37	1	248004808	248004808	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr1:248004808G>T	uc001idn.1	-	1	391	c.391C>A	c.(391-393)CGC>AGC	p.R131S		NM_001001959	NP_001001959	Q8NGX0	O11L1_HUMAN	olfactory receptor, family 11, subfamily L,	131	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|pancreas(1)|skin(1)	3	all_cancers(71;8.78e-05)|all_epithelial(71;9.15e-06)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.0786)|Lung NSC(105;0.0858)		OV - Ovarian serous cystadenocarcinoma(106;0.0319)			AAGGGGTAGCGGAGTGGGCTG	0.587		NA											12	29					5.51e-06	6.26e-06	1	0
OR11L1	391189	broad.mit.edu	37	1	248005080	248005080	+	Missense_Mutation	SNP	A	A	G			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr1:248005080A>G	uc001idn.1	-	1	119	c.119T>C	c.(118-120)ATA>ACA	p.I40T		NM_001001959	NP_001001959	Q8NGX0	O11L1_HUMAN	olfactory receptor, family 11, subfamily L,	40	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|pancreas(1)|skin(1)	3	all_cancers(71;8.78e-05)|all_epithelial(71;9.15e-06)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.0786)|Lung NSC(105;0.0858)		OV - Ovarian serous cystadenocarcinoma(106;0.0319)			AACATTCCCTATAATGGTCAG	0.502		NA											14	28					0	0	0	0
OR2T11	127077	broad.mit.edu	37	1	248790416	248790416	+	Nonsense_Mutation	SNP	G	G	C			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr1:248790416G>C	uc001ier.1	-	1	14	c.14C>G	c.(13-15)TCA>TGA	p.S5*		NM_001001964	NP_001001964	Q8NH01	O2T11_HUMAN	olfactory receptor, family 2, subfamily T,	5	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			lung(1)	1	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			GTCAGAGGATGATGTGTTCGT	0.547		NA											17	44					0	0	0	0
OR2T27	403239	broad.mit.edu	37	1	248813780	248813780	+	Missense_Mutation	SNP	T	T	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr1:248813780T>A	uc010pzo.1	-	1	406	c.406A>T	c.(406-408)ATG>TTG	p.M136L		NM_001001824	NP_001001824	Q8NH04	O2T27_HUMAN	olfactory receptor, family 2, subfamily T,	136	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	all_cancers(71;1.15e-05)|all_epithelial(71;5.29e-06)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.089)|Lung NSC(105;0.0969)|Melanoma(84;0.199)	all_cancers(173;0.237)	OV - Ovarian serous cystadenocarcinoma(106;0.0265)			TTGCGGCTCATGAGGACAGGA	0.557		NA											20	48					0	0	0	0
SEPHS1	22929	broad.mit.edu	37	10	13378324	13378324	+	Silent	SNP	G	G	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr10:13378324G>A	uc001imk.2	-	4	683	c.324C>T	c.(322-324)CTC>CTT	p.L108L	SEPHS1_uc001imh.2_Silent_p.L32L|SEPHS1_uc010qbs.1_Silent_p.L60L|SEPHS1_uc001imi.2_Silent_p.L108L|SEPHS1_uc001imj.2_Silent_p.L108L|SEPHS1_uc010qbt.1_Silent_p.L41L|SEPHS1_uc009xje.2_Silent_p.L108L	NM_012247	NP_036379	P49903	SPS1_HUMAN	selenophosphate synthetase 1	108					protein modification process		ATP binding|GTP binding|selenide, water dikinase activity			skin(1)	1						AGAGGTCACTGAGGACATTGG	0.517		NA											10	69					0	0	0	0
C1QL3	389941	broad.mit.edu	37	10	16562732	16562732	+	Silent	SNP	G	G	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr10:16562732G>A	uc001ioj.1	-	1	1273	c.333C>T	c.(331-333)AAC>AAT	p.N111N		NM_001010908	NP_001010908	Q5VWW1	C1QL3_HUMAN	complement component 1, q subcomponent-like 3	111	Collagen-like.					collagen				ovary(1)	1						CCCCGGCCGCGTTCAggccgg	0.632		NA											6	48					0	0	0	0
CUBN	8029	broad.mit.edu	37	10	16870935	16870935	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr10:16870935C>G	uc001ioo.2	-	66	10685	c.10633G>C	c.(10633-10635)GCT>CCT	p.A3545P		NM_001081	NP_001072	O60494	CUBN_HUMAN	cubilin precursor	3545	CUB 27.				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			ovary(9)|breast(4)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|kidney(1)	19					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	AGCCTTCCAGCAGGAGCAACA	0.522		NA											65	44					0	0	0	0
CUBN	8029	broad.mit.edu	37	10	16916401	16916401	+	Missense_Mutation	SNP	C	C	A	rs144314567		TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr10:16916401C>A	uc001ioo.2	-	58	9260	c.9208G>T	c.(9208-9210)GTT>TTT	p.V3070F	CUBN_uc009xjq.1_RNA|CUBN_uc009xjr.1_Missense_Mutation_p.V426F	NM_001081	NP_001072	O60494	CUBN_HUMAN	cubilin precursor	3070	CUB 23.				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			ovary(9)|breast(4)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|kidney(1)	19					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	TCGTCACTAACGGTGATGGTA	0.403		NA											27	156					0.000117367	0.000128836	1	0
ARHGAP21	57584	broad.mit.edu	37	10	24880577	24880577	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr10:24880577C>A	uc001isb.2	-	23	4525	c.4038G>T	c.(4036-4038)GAG>GAT	p.E1346D	ARHGAP21_uc010qdb.1_RNA	NM_020824	NP_065875	Q5T5U3	RHG21_HUMAN	Rho GTPase activating protein 21	1345					signal transduction	cell junction|cytoplasmic vesicle membrane|cytoskeleton|Golgi membrane	GTPase activator activity|protein binding			ovary(7)|pancreas(1)	8						TTACAAGAGGCTCTTCAGCAC	0.393		NA											33	161					8.74e-17	1.19e-16	1	0
GPR158	57512	broad.mit.edu	37	10	25885717	25885717	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr10:25885717G>A	uc001isj.2	+	10	2204	c.2144G>A	c.(2143-2145)CGG>CAG	p.R715Q	GPR158_uc001isk.2_Missense_Mutation_p.R90Q	NM_020752	NP_065803	Q5T848	GP158_HUMAN	G protein-coupled receptor 158 precursor	715	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(4)|large_intestine(2)|pancreas(1)|skin(1)	8						GAGGACATTCGGGTAATGCCA	0.488		NA											87	63					0	0	0	0
RET	5979	broad.mit.edu	37	10	43608405	43608405	+	Missense_Mutation	SNP	T	T	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr10:43608405T>A	uc001jal.2	+	9	1943	c.1753T>A	c.(1753-1755)TGC>AGC	p.C585S	RET_uc001jak.1_Missense_Mutation_p.C585S|RET_uc010qez.1_Missense_Mutation_p.C331S	NM_020975	NP_066124	P07949	RET_HUMAN	ret proto-oncogene isoform a	585	Extracellular (Potential).				homophilic cell adhesion|positive regulation of metanephric glomerulus development|positive regulation of transcription, DNA-dependent|posterior midgut development	integral to membrane	ATP binding|calcium ion binding|transmembrane receptor protein tyrosine kinase activity			thyroid(404)|adrenal_gland(20)|lung(9)|large_intestine(5)|breast(4)|ovary(4)|central_nervous_system(3)|urinary_tract(1)|NS(1)	451		Ovarian(717;0.0423)			Sunitinib(DB01268)	CCCTCAGGACTGCCTCCGTAA	0.572		1	T|Mis|N|F	H4|PRKAR1A|NCOA4|PCM1|GOLGA5|TRIM33|KTN1|TRIM27|HOOK3	medullary thyroid| papillary thyroid|pheochromocytoma	medullary thyroid| papillary thyroid|pheochromocytoma	Hirschsprung disease		Multiple_Endocrine_Neoplasia_type_2B|Multiple_Endocrine_Neoplasia_type_2A|Familial_Medullary_Thyroid_Carcinoma				13	27					0	0	0	0
C10orf72	196740	broad.mit.edu	37	10	50255035	50255035	+	Missense_Mutation	SNP	A	A	C			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr10:50255035A>C	uc001jhf.2	-	7	859	c.830T>G	c.(829-831)GTC>GGC	p.V277G		NM_001031746	NP_001026916	Q8IW00	CJ072_HUMAN	hypothetical protein LOC196740 isoform 1	277	Cytoplasmic (Potential).					integral to membrane|plasma membrane					0						TACCAGCGTGACTTTTCTCTG	0.453		NA											60	143					0	0	0	0
SGMS1	259230	broad.mit.edu	37	10	52103623	52103623	+	Silent	SNP	G	G	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr10:52103623G>A	uc001jje.2	-	7	1206	c.252C>T	c.(250-252)CAC>CAT	p.H84H	SGMS1_uc010qhk.1_Intron|SGMS1_uc009xot.1_Intron|SGMS1_uc009xou.1_Silent_p.H84H|SGMS1_uc010qhl.1_RNA	NM_147156	NP_671512	Q86VZ5	SMS1_HUMAN	sphingomyelin synthase 1	90					apoptosis|cell growth|sphingomyelin biosynthetic process	endoplasmic reticulum|Golgi trans cisterna|integral to Golgi membrane|nucleus|plasma membrane	ceramide cholinephosphotransferase activity|kinase activity|sphingomyelin synthase activity			ovary(1)|kidney(1)	2						CAATGTTGAGGTGCCCATTGG	0.512		NA											22	54					0	0	0	0
ANK3	288	broad.mit.edu	37	10	61828625	61828625	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr10:61828625C>T	uc001jky.2	-	37	12206	c.12014G>A	c.(12013-12015)GGT>GAT	p.G4005D	ANK3_uc001jkw.2_Intron|ANK3_uc009xpa.2_Intron|ANK3_uc001jkx.2_Intron|ANK3_uc010qih.1_Intron|ANK3_uc001jkz.3_Intron|ANK3_uc001jkv.2_Intron|ANK3_uc009xpb.1_Intron	NM_020987	NP_066267	Q12955	ANK3_HUMAN	ankyrin 3 isoform 1	4005					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			skin(9)|ovary(6)|pancreas(2)|central_nervous_system(2)	19						TAAGGTCTCACCACTAATTCC	0.368		NA											38	88					0	0	0	0
LRRTM3	347731	broad.mit.edu	37	10	68687991	68687991	+	Nonsense_Mutation	SNP	C	C	G			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr10:68687991C>G	uc001jmz.1	+	2	1867	c.1317C>G	c.(1315-1317)TAC>TAG	p.Y439*	CTNNA3_uc009xpn.1_Intron|CTNNA3_uc001jmw.2_Intron|CTNNA3_uc001jmx.3_Intron|CTNNA3_uc009xpo.1_Intron|LRRTM3_uc001jmy.2_Nonsense_Mutation_p.Y439*	NM_178011	NP_821079	Q86VH5	LRRT3_HUMAN	leucine rich repeat transmembrane neuronal 3	439	Helical; (Potential).					integral to membrane				upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3						TGGTTATCTACGTGTCATGGA	0.542		NA											26	86					0	0	0	0
GRID1	2894	broad.mit.edu	37	10	87487768	87487768	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr10:87487768C>A	uc001kdl.1	-	10	1478	c.1377G>T	c.(1375-1377)CAG>CAT	p.Q459H	GRID1_uc009xsu.1_RNA|GRID1_uc010qmf.1_Missense_Mutation_p.Q30H	NM_017551	NP_060021	Q9ULK0	GRID1_HUMAN	glutamate receptor, ionotropic, delta 1	459	Extracellular (Potential).					cell junction|integral to membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			ovary(5)|upper_aerodigestive_tract(2)|large_intestine(2)|central_nervous_system(1)	10					L-Glutamic Acid(DB00142)	AGCGCTTGGGCTGTCCTAGGA	0.473		NA								Multiple Myeloma(13;0.14)			38	54					1.23e-20	1.71e-20	1	0
IFIT5	24138	broad.mit.edu	37	10	91177811	91177811	+	Silent	SNP	G	G	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr10:91177811G>A	uc010qnh.1	+	2	1086	c.855G>A	c.(853-855)CTG>CTA	p.L285L	IFIT5_uc010qng.1_Silent_p.L237L	NM_012420	NP_036552	Q13325	IFIT5_HUMAN	interferon-induced protein with	285							binding				0						CTTCTTTCCTGCATCACCAGA	0.423		NA											33	35					0	0	0	0
PLCE1	51196	broad.mit.edu	37	10	95995801	95995801	+	Nonsense_Mutation	SNP	G	G	T			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr10:95995801G>T	uc001kjk.2	+	7	2978	c.2344G>T	c.(2344-2346)GAG>TAG	p.E782*	PLCE1_uc010qnx.1_Nonsense_Mutation_p.E782*|PLCE1_uc001kjm.2_Nonsense_Mutation_p.E474*	NM_016341	NP_057425	Q9P212	PLCE1_HUMAN	phospholipase C, epsilon 1 isoform 1	782	Ras-GEF.				activation of MAPK activity|activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|calcium-mediated signaling|cell proliferation|cytoskeleton organization|diacylglycerol biosynthetic process|elevation of cytosolic calcium ion concentration|epidermal growth factor receptor signaling pathway|glomerulus development|heart development|lipid catabolic process|Ras protein signal transduction|regulation of cell growth|regulation of G-protein coupled receptor protein signaling pathway|regulation of Ras protein signal transduction|regulation of smooth muscle contraction	cytosol|Golgi membrane|membrane fraction|plasma membrane	calcium ion binding|guanyl-nucleotide exchange factor activity|phosphatidylinositol phospholipase C activity|Ras GTPase binding|receptor signaling protein activity			ovary(2)|skin(1)	3		Colorectal(252;0.0458)				TCGAAGTCTGGAGACAGACGA	0.468		NA											15	16					1.36e-06	1.58e-06	1	0
CYP2C8	1558	broad.mit.edu	37	10	96796938	96796938	+	Missense_Mutation	SNP	T	T	G			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr10:96796938T>G	uc001kkb.2	-	9	1515	c.1420A>C	c.(1420-1422)AAA>CAA	p.K474Q	CYP2C8_uc001kkc.2_RNA|CYP2C8_uc010qoa.1_Missense_Mutation_p.K404Q|CYP2C8_uc010qob.1_Missense_Mutation_p.K388Q|CYP2C8_uc010qoc.1_Missense_Mutation_p.K372Q	NM_000770	NP_000761	P10632	CP2C8_HUMAN	cytochrome P450, family 2, subfamily C,	474					exogenous drug catabolic process|organic acid metabolic process|oxidative demethylation|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|caffeine oxidase activity|electron carrier activity|heme binding|oxygen binding				0		Colorectal(252;0.0397)		all cancers(201;6.21e-05)	Aminophenazone(DB01424)|Amiodarone(DB01118)|Amodiaquine(DB00613)|Benzphetamine(DB00865)|Carbamazepine(DB00564)|Cerivastatin(DB00439)|Diclofenac(DB00586)|Fluvastatin(DB01095)|Fosphenytoin(DB01320)|Gemfibrozil(DB01241)|Ketoconazole(DB01026)|Lapatinib(DB01259)|Lovastatin(DB00227)|Midazolam(DB00683)|Montelukast(DB00471)|Nicardipine(DB00622)|Paclitaxel(DB01229)|Phenytoin(DB00252)|Pioglitazone(DB01132)|Repaglinide(DB00912)|Rifampin(DB01045)|Rosiglitazone(DB00412)|Simvastatin(DB00641)|Sitagliptin(DB01261)|Tolbutamide(DB01124)|Torasemide(DB00214)|Tretinoin(DB00755)|Trimethoprim(DB00440)|Warfarin(DB00682)|Zafirlukast(DB00549)|Zopiclone(DB01198)	ACAATCCCTTTGGTAACTGCA	0.428		NA											13	24					0	0	0	0
SLIT1	6585	broad.mit.edu	37	10	98770785	98770785	+	Silent	SNP	G	G	C			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr10:98770785G>C	uc001kmw.2	-	31	3558	c.3306C>G	c.(3304-3306)GTC>GTG	p.V1102V		NM_003061	NP_003052	O75093	SLIT1_HUMAN	slit homolog 1 precursor	1102	EGF-like 5.				axon extension involved in axon guidance|forebrain morphogenesis|motor axon guidance|negative chemotaxis|negative regulation of synaptogenesis	cytoplasm|extracellular space	calcium ion binding|Roundabout binding			ovary(4)	4		Colorectal(252;0.162)		Epithelial(162;2.02e-08)|all cancers(201;1.5e-06)		AGTAGCTGTTGACTTCATCCA	0.592		NA											6	18					0	0	0	0
SEC31B	25956	broad.mit.edu	37	10	102256959	102256959	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr10:102256959C>A	uc001krc.1	-	17	2171	c.2069G>T	c.(2068-2070)GGG>GTG	p.G690V	SEC31B_uc010qpo.1_Missense_Mutation_p.G689V|SEC31B_uc001krd.1_Missense_Mutation_p.G227V|SEC31B_uc001krf.1_Missense_Mutation_p.G227V|SEC31B_uc001kre.1_Missense_Mutation_p.G227V|SEC31B_uc001krg.1_Missense_Mutation_p.G259V	NM_015490	NP_056305	Q9NQW1	SC31B_HUMAN	SEC31 homolog B	690	WD 7.				protein transport|vesicle-mediated transport	endoplasmic reticulum membrane|ER to Golgi transport vesicle membrane				ovary(1)	1		Colorectal(252;0.117)		Epithelial(162;2.36e-10)|all cancers(201;2.09e-08)		CTCCACACTCCCTGAGCACAC	0.582		NA											15	43					7.93e-07	9.27e-07	1	0
CALHM1	255022	broad.mit.edu	37	10	105218107	105218107	+	Silent	SNP	G	G	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr10:105218107G>A	uc001kxe.2	-	1	542	c.402C>T	c.(400-402)CCC>CCT	p.P134P		NM_001001412	NP_001001412	Q8IU99	CAHM1_HUMAN	calcium homeostasis modulator 1	134						endoplasmic reticulum membrane|integral to membrane|plasma membrane	calcium channel activity|identical protein binding			ovary(1)	1						GTGCGCTCACGGGCACGGCAG	0.706		NA											10	17					0	0	0	0
NRAP	4892	broad.mit.edu	37	10	115350515	115350515	+	Missense_Mutation	SNP	A	A	G			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr10:115350515A>G	uc001laj.2	-	40	4942	c.4778T>C	c.(4777-4779)TTT>TCT	p.F1593S	NRAP_uc009xyb.2_Missense_Mutation_p.F346S|NRAP_uc001lak.2_Missense_Mutation_p.F1558S|NRAP_uc001lal.3_Missense_Mutation_p.F1593S	NM_198060	NP_932326	Q86VF7	NRAP_HUMAN	nebulin-related anchoring protein isoform S	1593	Nebulin 42.					fascia adherens|muscle tendon junction	actin binding|muscle alpha-actinin binding|zinc ion binding			ovary(6)|central_nervous_system(3)|upper_aerodigestive_tract(1)	10		Colorectal(252;0.0233)|Breast(234;0.188)		Epithelial(162;0.00392)|all cancers(201;0.00569)		ACTCTTGGCAAAGTCCTTCTT	0.577		NA											26	63					0	0	0	0
ATRNL1	26033	broad.mit.edu	37	10	117061411	117061411	+	Silent	SNP	G	G	T			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr10:117061411G>T	uc001lcg.2	+	17	3062	c.2676G>T	c.(2674-2676)CTG>CTT	p.L892L	ATRNL1_uc010qsm.1_Silent_p.L67L|ATRNL1_uc010qsn.1_RNA	NM_207303	NP_997186	Q5VV63	ATRN1_HUMAN	attractin-like 1 precursor	892	PSI 4.|Extracellular (Potential).					integral to membrane	sugar binding			ovary(5)|lung(1)|central_nervous_system(1)	7		all_lung(145;0.0686)|Breast(234;0.0969)|Lung NSC(174;0.17)|Colorectal(252;0.234)		Epithelial(162;0.00031)|all cancers(201;0.000753)|LUSC - Lung squamous cell carcinoma(1;0.0515)|Lung(30;0.0827)		CATGCTCTCTGAGGACATCAT	0.378		NA											16	48					0.000308642	0.000335253	1	0
PNLIPRP2	5408	broad.mit.edu	37	10	118386463	118386463	+	Missense_Mutation	SNP	T	T	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr10:118386463T>A	uc001lcq.2	+	7	445	c.422T>A	c.(421-423)ATT>AAT	p.I141N	PNLIPRP2_uc009xyu.1_RNA|PNLIPRP2_uc009xyv.1_RNA	NM_005396	NP_005387	P54317	LIPR2_HUMAN	pancreatic lipase-related protein 2	140					galactolipid catabolic process|lipid digestion|phospholipid catabolic process|triglyceride metabolic process	extracellular space	acylglycerol lipase activity|calcium ion binding|galactolipase activity|phospholipase activity|triglyceride lipase activity			large_intestine(1)	1				all cancers(201;0.015)		GTGCAAAACATTCGGGTTGTT	0.557		NA											8	11					0	0	0	0
BTBD16	118663	broad.mit.edu	37	10	124036332	124036332	+	Silent	SNP	C	C	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr10:124036332C>A	uc001lgc.1	+	3	296	c.45C>A	c.(43-45)GTC>GTA	p.V15V	BTBD16_uc001lgd.1_Silent_p.V14V	NM_144587	NP_653188	Q32M84	BTBDG_HUMAN	BTB (POZ) domain containing 16	15										skin(1)	1		all_neural(114;0.107)|Lung NSC(174;0.175)|all_lung(145;0.222)|Breast(234;0.238)				AACGCCGGGTCACTGGCTCAA	0.478		NA											22	92					1.96e-10	2.47e-10	1	0
DMBT1	1755	broad.mit.edu	37	10	124399936	124399936	+	Silent	SNP	G	G	C	rs112912048		TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr10:124399936G>C	uc001lgk.1	+	52	7042	c.6936G>C	c.(6934-6936)ACG>ACC	p.T2312T	DMBT1_uc001lgl.1_Silent_p.T2302T|DMBT1_uc001lgm.1_Silent_p.T1684T|DMBT1_uc009xzz.1_Silent_p.T2311T|DMBT1_uc010qtx.1_Silent_p.T1032T|DMBT1_uc009yab.1_Silent_p.T1015T|DMBT1_uc009yac.1_Silent_p.T606T	NM_007329	NP_015568	Q9UGM3	DMBT1_HUMAN	deleted in malignant brain tumors 1 isoform b	2312	ZP.				epithelial cell differentiation|induction of bacterial agglutination|innate immune response|interspecies interaction between organisms|protein transport|response to virus	extrinsic to membrane|phagocytic vesicle membrane|zymogen granule membrane	calcium-dependent protein binding|Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|pattern recognition receptor activity|scavenger receptor activity|zymogen binding			central_nervous_system(7)	7		all_neural(114;0.0765)|Lung NSC(174;0.132)|all_lung(145;0.163)|Breast(234;0.238)				ATGACTTCACGTCTTTGACTT	0.458		NA											19	40					0	0	0	0
FAM53B	9679	broad.mit.edu	37	10	126370314	126370314	+	Silent	SNP	C	C	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr10:126370314C>A	uc001lhv.1	-	4	1291	c.768G>T	c.(766-768)CTG>CTT	p.L256L	FAM53B_uc001lhu.1_Silent_p.L256L|FAM53B_uc001lhw.2_Silent_p.L256L	NM_014661	NP_055476	Q14153	FA53B_HUMAN	hypothetical protein LOC9679	256										ovary(1)|pancreas(1)	2		all_lung(145;0.0191)|Lung NSC(174;0.0301)|Colorectal(57;0.106)|all_neural(114;0.117)		COAD - Colon adenocarcinoma(40;0.141)|Colorectal(40;0.15)		AGCGTCTCGCCAGCTCTGGTG	0.587		NA											4	13					3.6e-05	4.01e-05	1	0
ADAM8	101	broad.mit.edu	37	10	135086312	135086312	+	Missense_Mutation	SNP	T	T	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr10:135086312T>A	uc010qva.1	-	7	629	c.578A>T	c.(577-579)CAC>CTC	p.H193L	ADAM8_uc010quz.1_Missense_Mutation_p.H232L|ADAM8_uc009ybi.2_Missense_Mutation_p.H232L|ADAM8_uc010qvb.1_Missense_Mutation_p.H207L|ADAM8_uc009ybj.1_RNA			P78325	ADAM8_HUMAN	SubName: Full=cDNA FLJ50704, highly similar to ADAM 8 (EC 3.4.24.-) (A disintegrinand metalloproteinase domain 8);	193					integrin-mediated signaling pathway|proteolysis		metalloendopeptidase activity			large_intestine(2)|central_nervous_system(1)	3		all_cancers(35;1.14e-09)|all_epithelial(44;5.79e-08)|Lung NSC(174;0.00263)|all_lung(145;0.0039)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.172)|Glioma(114;0.203)		all cancers(32;7.72e-06)|OV - Ovarian serous cystadenocarcinoma(35;8.23e-06)|Epithelial(32;1.02e-05)		CTTGTCCACGTGATTCACCAC	0.672		NA											14	23					0	0	0	0
PHRF1	57661	broad.mit.edu	37	11	608731	608731	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr11:608731G>T	uc001lqe.2	+	14	3406	c.3275G>T	c.(3274-3276)CGG>CTG	p.R1092L	PHRF1_uc010qwc.1_Missense_Mutation_p.R1091L|PHRF1_uc010qwd.1_Missense_Mutation_p.R1090L|PHRF1_uc010qwe.1_Missense_Mutation_p.R1088L|PHRF1_uc009ybz.1_Missense_Mutation_p.R882L|PHRF1_uc009yca.1_RNA	NM_020901	NP_065952	Q9P1Y6	PHRF1_HUMAN	PHD and ring finger domains 1	1092	Arg-rich.						RNA polymerase binding|zinc ion binding				0						TCCCGGTCGCGGTCGGGGAGC	0.632		NA											12	19					1.62e-10	2.04e-10	1	0
MUC2	4583	broad.mit.edu	37	11	1078313	1078313	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr11:1078313C>A	uc001lsx.1	+	5	627	c.600C>A	c.(598-600)AAC>AAA	p.N200K		NM_002457	NP_002448	Q02817	MUC2_HUMAN	mucin 2 precursor	200	VWFD 1.					inner mucus layer|outer mucus layer	protein binding			lung(1)|breast(1)	2		all_cancers(49;1.08e-07)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.191)		BRCA - Breast invasive adenocarcinoma(625;0.000207)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)	Pranlukast(DB01411)	AGAAGATCAACCAGCCCGATG	0.662		NA											27	69					1.79e-09	2.22e-09	1	0
OR52I2	143502	broad.mit.edu	37	11	4608485	4608485	+	Missense_Mutation	SNP	T	T	C			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr11:4608485T>C	uc010qyh.1	+	1	443	c.443T>C	c.(442-444)ATG>ACG	p.M148T		NM_001005170	NP_001005170	Q8NH67	O52I2_HUMAN	olfactory receptor, family 52, subfamily I,	148	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(1)	1		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;8.45e-12)|BRCA - Breast invasive adenocarcinoma(625;0.0285)|LUSC - Lung squamous cell carcinoma(625;0.19)		CTGCTGACCATGGCTTTTGAC	0.493		NA											16	70					0	0	0	0
TRIM68	55128	broad.mit.edu	37	11	4621844	4621844	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr11:4621844C>G	uc001lzf.1	-	7	1358	c.1120G>C	c.(1120-1122)GTA>CTA	p.V374L	TRIM68_uc001lzg.1_Missense_Mutation_p.V151L|TRIM68_uc010qyj.1_RNA	NM_018073	NP_060543	Q6AZZ1	TRI68_HUMAN	ring finger protein 137	374	B30.2/SPRY.				protein autoubiquitination|regulation of androgen receptor signaling pathway	Golgi apparatus|nucleolus|perinuclear region of cytoplasm	androgen receptor binding|histone acetyltransferase binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)	1		Medulloblastoma(188;0.0025)|Breast(177;0.0101)|all_neural(188;0.0227)		Epithelial(150;9.49e-12)|BRCA - Breast invasive adenocarcinoma(625;0.0288)|LUSC - Lung squamous cell carcinoma(625;0.192)		TGCTTACATACTCCCAGGCCC	0.537		NA											18	29					0	0	0	0
HBG2	3048	broad.mit.edu	37	11	5275578	5275578	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr11:5275578C>T	uc001mai.1	-	2	696	c.259G>A	c.(259-261)GCC>ACC	p.A87T	HBG2_uc001mak.1_RNA|HBG2_uc001maj.1_Missense_Mutation_p.A87T	NM_000559	NP_000550	P69892	HBG2_HUMAN	A-gamma globin	87					blood coagulation	hemoglobin complex	heme binding|oxygen binding|oxygen transporter activity			skin(1)	1		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;2.76e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CTCAGCTGGGCAAAGGTGCCC	0.517		NA											25	197					0	0	0	0
OR51B6	390058	broad.mit.edu	37	11	5373081	5373081	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr11:5373081C>G	uc010qzb.1	+	1	344	c.344C>G	c.(343-345)GCC>GGC	p.A115G	HBG2_uc001mak.1_Intron|HBE1_uc001mam.1_Intron|OR51B5_uc001maq.1_Intron	NM_001004750	NP_001004750	Q9H340	O51B6_HUMAN	olfactory receptor, family 51, subfamily B,	115	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;2.9e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GTCTTGCTTGCCATGGCTTAT	0.473		NA											13	63					0	0	0	0
DNHD1	144132	broad.mit.edu	37	11	6588904	6588904	+	Silent	SNP	C	C	T			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr11:6588904C>T	uc001mdw.3	+	36	12729	c.12165C>T	c.(12163-12165)GCC>GCT	p.A4055A	DNHD1_uc001mea.3_Silent_p.A324A|DNHD1_uc001meb.2_Silent_p.A323A|DNHD1_uc001mec.2_Silent_p.A323A|DNHD1_uc010rao.1_Silent_p.A313A|DNHD1_uc009yfg.2_5'Flank	NM_144666	NP_653267	Q96M86	DNHD1_HUMAN	dynein heavy chain domain 1 isoform 1	4055					microtubule-based movement	dynein complex	microtubule motor activity			ovary(2)	2		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.171)		Epithelial(150;3.93e-08)|BRCA - Breast invasive adenocarcinoma(625;0.13)		TGGCAGGTGCCCTGGCAGACT	0.617		NA											16	38					0	0	0	0
DNHD1	144132	broad.mit.edu	37	11	6589744	6589744	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr11:6589744C>G	uc001mdw.3	+	38	13163	c.12599C>G	c.(12598-12600)ACT>AGT	p.T4200S	DNHD1_uc001mea.3_Missense_Mutation_p.T469S|DNHD1_uc001meb.2_Missense_Mutation_p.T468S|DNHD1_uc001mec.2_Missense_Mutation_p.T468S|DNHD1_uc010rao.1_Missense_Mutation_p.T458S|DNHD1_uc009yfg.2_5'UTR	NM_144666	NP_653267	Q96M86	DNHD1_HUMAN	dynein heavy chain domain 1 isoform 1	4200					microtubule-based movement	dynein complex	microtubule motor activity			ovary(2)	2		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.171)		Epithelial(150;3.93e-08)|BRCA - Breast invasive adenocarcinoma(625;0.13)		AATGTAAGCACTGTTCACAGA	0.463		NA											24	48					0	0	0	0
OR6A2	8590	broad.mit.edu	37	11	6816345	6816345	+	Missense_Mutation	SNP	T	T	C			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr11:6816345T>C	uc001mes.1	-	1	795	c.595A>G	c.(595-597)ACA>GCA	p.T199A		NM_003696	NP_003687	O95222	OR6A2_HUMAN	olfactory receptor, family 6, subfamily A,	199	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(3)|central_nervous_system(1)|pancreas(1)	5		Medulloblastoma(188;0.0523)|all_neural(188;0.236)		Epithelial(150;4.78e-08)|BRCA - Breast invasive adenocarcinoma(625;0.129)		AGCTCTGCTGTGGACATATCA	0.468		NA											37	98					0	0	0	0
FAR1	84188	broad.mit.edu	37	11	13743308	13743308	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr11:13743308G>T	uc001mld.2	+	10	1314	c.1159G>T	c.(1159-1161)GCT>TCT	p.A387S		NM_032228	NP_115604	Q8WVX9	FACR1_HUMAN	fatty acyl CoA reductase 1	387					ether lipid biosynthetic process	integral to membrane|peroxisomal matrix|peroxisomal membrane	protein binding			ovary(1)|skin(1)	2						TCTTCACAAAGCTATGGTGTT	0.328		NA											24	39					9.58e-11	1.22e-10	1	0
INSC	387755	broad.mit.edu	37	11	15197552	15197552	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr11:15197552G>C	uc001mly.2	+	3	509	c.463G>C	c.(463-465)GTG>CTG	p.V155L	INSC_uc001mlz.2_Missense_Mutation_p.V108L|INSC_uc001mma.2_Missense_Mutation_p.V108L|INSC_uc010rcs.1_Missense_Mutation_p.V108L|INSC_uc001mmb.2_Missense_Mutation_p.V108L|INSC_uc001mmc.2_Missense_Mutation_p.V108L	NM_001031853	NP_001027024	Q1MX18	INSC_HUMAN	inscuteable isoform a	155					cell differentiation|nervous system development	cytoplasm	binding			upper_aerodigestive_tract(2)|ovary(2)|central_nervous_system(1)	5						CAGCATGAGCGTGCGTCTGAC	0.627		NA											8	10					0	0	0	0
INSC	387755	broad.mit.edu	37	11	15260566	15260566	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr11:15260566C>A	uc001mly.2	+	11	1526	c.1480C>A	c.(1480-1482)CTG>ATG	p.L494M	INSC_uc001mlz.2_Missense_Mutation_p.L447M|INSC_uc001mma.2_Missense_Mutation_p.L447M|INSC_uc010rcs.1_Missense_Mutation_p.L482M|INSC_uc001mmb.2_Missense_Mutation_p.L447M|INSC_uc001mmc.2_Missense_Mutation_p.L405M	NM_001031853	NP_001027024	Q1MX18	INSC_HUMAN	inscuteable isoform a	494					cell differentiation|nervous system development	cytoplasm	binding			upper_aerodigestive_tract(2)|ovary(2)|central_nervous_system(1)	5						TGCAGTGACCCTGGCTCGTCT	0.602		NA											16	26					1.15e-07	1.37e-07	1	0
PLEKHA7	144100	broad.mit.edu	37	11	16834669	16834669	+	Silent	SNP	C	C	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr11:16834669C>A	uc001mmo.2	-	13	2013	c.1998G>T	c.(1996-1998)CTG>CTT	p.L666L	PLEKHA7_uc010rcu.1_Silent_p.L666L|PLEKHA7_uc010rcv.1_Silent_p.L240L|PLEKHA7_uc001mmn.2_Silent_p.L374L	NM_175058	NP_778228	Q6IQ23	PKHA7_HUMAN	pleckstrin homology domain containing, family A	666	Interaction with CTNND1.				epithelial cell-cell adhesion|zonula adherens maintenance	centrosome|zonula adherens	delta-catenin binding			skin(2)|central_nervous_system(1)	3						CCTTTAGATCCAGGTACTCCA	0.468		NA											15	34					7.93e-07	9.27e-07	1	0
SERGEF	26297	broad.mit.edu	37	11	18010157	18010157	+	Silent	SNP	C	C	G			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr11:18010157C>G	uc001mnm.2	-	8	911	c.831G>C	c.(829-831)CTG>CTC	p.L277L	SERGEF_uc009yhd.2_RNA|SERGEF_uc001mnn.2_Silent_p.L277L|SERGEF_uc010rcz.1_Silent_p.L163L|SERGEF_uc001mno.1_Silent_p.L163L	NM_012139	NP_036271	Q9UGK8	SRGEF_HUMAN	deafness locus associated putative guanine	277	RCC1 5.				negative regulation of protein secretion|signal transduction	cytoplasm|nucleus	protein binding|Ran guanyl-nucleotide exchange factor activity			central_nervous_system(1)	1						TCTGAGCAACCAGGTGTGTCC	0.507		NA											26	43					0	0	0	0
LDHC	3948	broad.mit.edu	37	11	18472631	18472631	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr11:18472631G>T	uc001mon.3	+	8	1068	c.956G>T	c.(955-957)AGT>ATT	p.S319I	LDHC_uc001mom.3_Missense_Mutation_p.S319I|LDHC_uc009yhp.2_3'UTR|LDHC_uc001moo.3_Missense_Mutation_p.S203I|LDHC_uc009yhq.2_RNA|LDHC_uc009yhr.2_3'UTR	NM_017448	NP_059144	P07864	LDHC_HUMAN	L-lactate dehydrogenase C	319					glycolysis	cytoplasm	binding|L-lactate dehydrogenase activity				0					NADH(DB00157)	TTCAAGAAGAGTGCAGAAACA	0.388		NA											29	55					1.25e-16	1.7e-16	1	0
ANO5	203859	broad.mit.edu	37	11	22271793	22271793	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr11:22271793G>A	uc001mqi.2	+	10	1206	c.889G>A	c.(889-891)GGA>AGA	p.G297R	ANO5_uc001mqj.2_Missense_Mutation_p.G296R	NM_213599	NP_998764	Q75V66	ANO5_HUMAN	anoctamin 5 isoform a	297	Cytoplasmic (Potential).					chloride channel complex|endoplasmic reticulum membrane	chloride channel activity			central_nervous_system(3)|ovary(1)	4						GAATTATTATGGAGAAAAAAT	0.244		NA											10	20					0	0	0	0
MAPK8IP1	9479	broad.mit.edu	37	11	45924289	45924289	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr11:45924289G>A	uc001nbr.2	+	5	1141	c.971G>A	c.(970-972)CGG>CAG	p.R324Q		NM_005456	NP_005447	Q9UQF2	JIP1_HUMAN	mitogen-activated protein kinase 8 interacting	324					vesicle-mediated transport	nucleus|perinuclear region of cytoplasm	kinesin binding|MAP-kinase scaffold activity|protein kinase inhibitor activity			ovary(2)|breast(1)|skin(1)	4				GBM - Glioblastoma multiforme(35;0.231)		ACGGCAGGGCGGCCGCACCCC	0.711		NA											7	10					0	0	0	0
OR4B1	119765	broad.mit.edu	37	11	48239279	48239279	+	Silent	SNP	A	A	T			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr11:48239279A>T	uc010rhs.1	+	1	918	c.918A>T	c.(916-918)CCA>CCT	p.P306P		NM_001005470	NP_001005470	Q8NGF8	OR4B1_HUMAN	olfactory receptor, family 4, subfamily B,	306	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.P306T(1)		skin(2)|ovary(1)|pancreas(1)	4						AGGAGAATCCAGGGAGGGAGT	0.408		NA											11	31					0	0	0	0
OR5F1	338674	broad.mit.edu	37	11	55761731	55761731	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr11:55761731G>A	uc010riv.1	-	1	371	c.371C>T	c.(370-372)GCG>GTG	p.A124V		NM_003697	NP_003688	O95221	OR5F1_HUMAN	olfactory receptor, family 5, subfamily F,	124	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|pancreas(1)	2	Esophageal squamous(21;0.00448)					ACATATGGCCGCATACCTGTC	0.507		NA											3	32					0	0	0	0
OR5M3	219482	broad.mit.edu	37	11	56237369	56237369	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr11:56237369C>A	uc010rjk.1	-	1	605	c.605G>T	c.(604-606)GGC>GTC	p.G202V		NM_001004742	NP_001004742	Q8NGP4	OR5M3_HUMAN	olfactory receptor, family 5, subfamily M,	202	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	Esophageal squamous(21;0.00448)					GAAGTTAATGCCGGCAAGTAT	0.418		NA											35	80					1.91e-15	2.58e-15	1	0
OR5M8	219484	broad.mit.edu	37	11	56258161	56258161	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr11:56258161G>T	uc001nix.1	-	1	686	c.686C>A	c.(685-687)TCT>TAT	p.S229Y		NM_001005282	NP_001005282	Q8NGP6	OR5M8_HUMAN	olfactory receptor, family 5, subfamily M,	229	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1	Esophageal squamous(21;0.00352)					GCCCTCTGTAGAGCGAATCTT	0.413		NA											17	34					4.15e-12	5.4e-12	1	0
OR5AR1	219493	broad.mit.edu	37	11	56431878	56431878	+	Silent	SNP	C	C	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr11:56431878C>A	uc010rjm.1	+	1	717	c.717C>A	c.(715-717)TCC>TCA	p.S239S		NM_001004730	NP_001004730	Q8NGP9	O5AR1_HUMAN	olfactory receptor, family 5, subfamily AR,	239	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						AGGCTTTCTCCACCTGCGGGT	0.483		NA											24	90					2.22e-12	2.89e-12	1	0
OR9I1	219954	broad.mit.edu	37	11	57886521	57886521	+	Silent	SNP	A	A	G			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr11:57886521A>G	uc001nml.1	-	1	396	c.396T>C	c.(394-396)TAT>TAC	p.Y132Y	OR9Q1_uc001nmj.2_Intron	NM_001005211	NP_001005211	Q8NGQ6	OR9I1_HUMAN	olfactory receptor, family 9, subfamily I,	132	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(1)	1		Breast(21;0.0589)				TGGCCACGGTATAGAGCAGTG	0.557		NA											12	38					0	0	0	0
MS4A4A	51338	broad.mit.edu	37	11	60073587	60073587	+	Missense_Mutation	SNP	G	G	T	rs148827848		TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr11:60073587G>T	uc001noz.2	+	6	571	c.561G>T	c.(559-561)ATG>ATT	p.M187I	MS4A4A_uc001npa.2_Missense_Mutation_p.M168I|MS4A4A_uc001npb.2_Missense_Mutation_p.M168I|MS4A4A_uc001npc.2_Missense_Mutation_p.M115I	NM_148975	NP_683876	Q96JQ5	M4A4A_HUMAN	membrane-spanning 4-domains, subfamily A, member	187	Helical; (Potential).					integral to membrane	receptor activity				0						TGGATGGCATGGTGCTCCTCC	0.458		NA											32	78					1.22e-17	1.68e-17	1	0
FAM86C	55199	broad.mit.edu	37	11	71507140	71507140	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr11:71507140C>A	uc001oqv.3	+	4	365	c.339C>A	c.(337-339)AGC>AGA	p.S113R	FAM86C_uc009ysr.2_Missense_Mutation_p.S106R|FAM86C_uc001oqw.3_Missense_Mutation_p.S79R|FAM86C_uc009yss.2_RNA|FAM86C_uc010rqq.1_RNA|uc001oqx.1_Intron	NM_018172	NP_060642	Q9NVL1	FA86C_HUMAN	hypothetical protein LOC55199 isoform 1	113											0						GGAGCACCAGCGGGCTCCTCA	0.632		NA											46	119					7.88e-25	1.12e-24	1	0
GDPD4	220032	broad.mit.edu	37	11	76940195	76940195	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr11:76940195C>A	uc001oyf.2	-	14	1723	c.1472G>T	c.(1471-1473)TGG>TTG	p.W491L		NM_182833	NP_878253	Q6W3E5	GDPD4_HUMAN	glycerophosphodiester phosphodiesterase domain	491	Cytoplasmic (Potential).				glycerol metabolic process|lipid metabolic process	integral to membrane	glycerophosphodiester phosphodiesterase activity|metal ion binding			skin(1)	1						atataCTTACCAGTGAAAACA	0.299		NA											8	21					5.18e-06	5.92e-06	1	0
FZD4	8322	broad.mit.edu	37	11	86662821	86662821	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr11:86662821G>A	uc001pce.2	-	2	1283	c.977C>T	c.(976-978)ACT>ATT	p.T326I	PRSS23_uc001pcc.1_RNA	NM_012193	NP_036325	Q9ULV1	FZD4_HUMAN	frizzled 4 precursor	326	Cytoplasmic (Potential).				canonical Wnt receptor signaling pathway|cellular response to retinoic acid|embryo development|negative regulation of cell-substrate adhesion|neuron differentiation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|progesterone secretion|regulation of vascular endothelial growth factor receptor signaling pathway|substrate adhesion-dependent cell spreading|vasculogenesis|Wnt receptor signaling pathway, calcium modulating pathway	cell projection|cell surface|cytoplasm	cytokine binding|G-protein coupled receptor activity|PDZ domain binding|protein heterodimerization activity|protein homodimerization activity|Wnt receptor activity|Wnt-protein binding			large_intestine(1)	1		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)				CAAAAACCAAGTGAGTGTCAG	0.453		NA											13	23					0	0	0	0
GRM5	2915	broad.mit.edu	37	11	88258477	88258477	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr11:88258477C>A	uc001pcq.2	-	8	2926	c.2726G>T	c.(2725-2727)AGT>ATT	p.S909I	GRM5_uc009yvm.2_Intron	NM_001143831	NP_001137303	P41594	GRM5_HUMAN	glutamate receptor, metabotropic 5 isoform a	909	Cytoplasmic (Potential).				activation of phospholipase C activity by metabotropic glutamate receptor signaling pathway|synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			central_nervous_system(4)|ovary(2)|lung(2)|breast(1)	9		Acute lymphoblastic leukemia(157;2.54e-05)|all_hematologic(158;0.00834)			Acamprosate(DB00659)	GTTTGCTTACCTGCTCATTGT	0.507		NA											73	191					2.38e-18	3.28e-18	1	0
FAT3	120114	broad.mit.edu	37	11	92087428	92087428	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr11:92087428C>T	uc001pdj.3	+	1	2167	c.2150C>T	c.(2149-2151)TCA>TTA	p.S717L		NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	717	Extracellular (Potential).				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				GACTTTTATTCAATTAATAGA	0.398		NA								TCGA Ovarian(4;0.039)			49	145					0	0	0	0
FAT3	120114	broad.mit.edu	37	11	92564960	92564960	+	Silent	SNP	T	T	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr11:92564960T>A	uc001pdj.3	+	13	9671	c.9654T>A	c.(9652-9654)TCT>TCA	p.S3218S		NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	3218	Cadherin 29.|Extracellular (Potential).				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				CCCTGTCCTCTCTCACTACTG	0.577		NA								TCGA Ovarian(4;0.039)			11	11					0	0	0	0
CNTN5	53942	broad.mit.edu	37	11	99715885	99715885	+	Silent	SNP	C	C	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr11:99715885C>A	uc001pga.2	+	6	807	c.468C>A	c.(466-468)ACC>ACA	p.T156T	CNTN5_uc009ywv.1_Silent_p.T156T|CNTN5_uc001pfz.2_Silent_p.T156T|CNTN5_uc001pgb.2_Silent_p.T82T	NM_014361	NP_055176	O94779	CNTN5_HUMAN	contactin 5 isoform long	156	Ig-like C2-type 1.				cell adhesion	anchored to membrane|plasma membrane	protein binding			skin(3)|ovary(2)|pancreas(2)|breast(1)	8		all_hematologic(158;1.22e-05)|Acute lymphoblastic leukemia(157;3.81e-05)|Melanoma(852;0.219)		BRCA - Breast invasive adenocarcinoma(274;0.00146)|KIRC - Kidney renal clear cell carcinoma(183;0.156)|Kidney(183;0.196)		TAGATGGCACCTTCATTATAA	0.373		NA											35	69					8.53e-09	1.04e-08	1	0
CNTN5	53942	broad.mit.edu	37	11	99941252	99941252	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr11:99941252C>G	uc001pga.2	+	11	1598	c.1259C>G	c.(1258-1260)ACG>AGG	p.T420R	CNTN5_uc009ywv.1_Missense_Mutation_p.T420R|CNTN5_uc001pfz.2_Missense_Mutation_p.T420R|CNTN5_uc001pgb.2_Missense_Mutation_p.T346R	NM_014361	NP_055176	O94779	CNTN5_HUMAN	contactin 5 isoform long	420	Ig-like C2-type 4.				cell adhesion	anchored to membrane|plasma membrane	protein binding			skin(3)|ovary(2)|pancreas(2)|breast(1)	8		all_hematologic(158;1.22e-05)|Acute lymphoblastic leukemia(157;3.81e-05)|Melanoma(852;0.219)		BRCA - Breast invasive adenocarcinoma(274;0.00146)|KIRC - Kidney renal clear cell carcinoma(183;0.156)|Kidney(183;0.196)		CCCAGACCCACGTATCGTTGG	0.478		NA											16	30					0	0	0	0
CNTN5	53942	broad.mit.edu	37	11	99944884	99944884	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr11:99944884C>A	uc001pga.2	+	13	1777	c.1438C>A	c.(1438-1440)CCC>ACC	p.P480T	CNTN5_uc009ywv.1_Missense_Mutation_p.P480T|CNTN5_uc001pfz.2_Missense_Mutation_p.P480T|CNTN5_uc001pgb.2_Missense_Mutation_p.P406T	NM_014361	NP_055176	O94779	CNTN5_HUMAN	contactin 5 isoform long	480	Ig-like C2-type 5.				cell adhesion	anchored to membrane|plasma membrane	protein binding			skin(3)|ovary(2)|pancreas(2)|breast(1)	8		all_hematologic(158;1.22e-05)|Acute lymphoblastic leukemia(157;3.81e-05)|Melanoma(852;0.219)		BRCA - Breast invasive adenocarcinoma(274;0.00146)|KIRC - Kidney renal clear cell carcinoma(183;0.156)|Kidney(183;0.196)		AGCTTCAGCTCCCACTTTTGC	0.368		NA											10	30					5.51e-06	6.26e-06	1	0
MMP10	4319	broad.mit.edu	37	11	102649421	102649421	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr11:102649421G>A	uc001phg.1	-	4	578	c.556C>T	c.(556-558)CCT>TCT	p.P186S		NM_002425	NP_002416	P09238	MMP10_HUMAN	matrix metalloproteinase 10 preproprotein	186					collagen catabolic process|proteolysis	extracellular space|proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			kidney(1)|lung(1)|breast(1)|central_nervous_system(1)	4	all_epithelial(12;0.00961)	all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)	Epithelial(9;0.0303)|Lung(13;0.0828)|all cancers(10;0.116)|LUSC - Lung squamous cell carcinoma(19;0.151)	BRCA - Breast invasive adenocarcinoma(274;0.0145)		CCAGGTCCAGGTGGGTAGGCA	0.423		NA											23	42					0	0	0	0
CARD16	114769	broad.mit.edu	37	11	104912149	104912149	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr11:104912149G>C	uc001pip.1	-	3	599	c.572C>G	c.(571-573)ACT>AGT	p.T191S	CASP1_uc010rve.1_Intron|CASP1_uc010rvf.1_Intron|CASP1_uc010rvg.1_Intron|CASP1_uc010rvh.1_Intron|CASP1_uc010rvi.1_Intron|CARD16_uc001pio.1_3'UTR	NM_001017534	NP_001017534	Q5EG05	CAR16_HUMAN	caspase-1 dominant-negative inhibitor pseudo-ICE	191					regulation of apoptosis	intracellular	cysteine-type endopeptidase inhibitor activity			skin(1)	1						ATGAGTTCCAGTTTGCAACTC	0.393		NA											21	35					0	0	0	0
GUCY1A2	2977	broad.mit.edu	37	11	106888648	106888648	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr11:106888648G>C	uc001pjg.1	-	1	524	c.134C>G	c.(133-135)CCG>CGG	p.P45R	GUCY1A2_uc010rvo.1_Missense_Mutation_p.P45R|GUCY1A2_uc009yxn.1_Missense_Mutation_p.P45R	NM_000855	NP_000846	P33402	GCYA2_HUMAN	guanylate cyclase 1, soluble, alpha 2	45					intracellular signal transduction|platelet activation	cytoplasm	GTP binding|guanylate cyclase activity|heme binding			large_intestine(3)|lung(2)|pancreas(2)|ovary(1)	8		all_epithelial(67;3.66e-05)|Melanoma(852;0.000382)|Acute lymphoblastic leukemia(157;0.001)|all_hematologic(158;0.0017)|Breast(348;0.026)|all_neural(303;0.068)		BRCA - Breast invasive adenocarcinoma(274;8.04e-05)|Epithelial(105;0.0036)|all cancers(92;0.0476)		GGGCTCCAGCGGCCCGGGCGG	0.473		NA											2	5					0	0	0	0
DRD2	1813	broad.mit.edu	37	11	113295162	113295162	+	Missense_Mutation	SNP	T	T	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr11:113295162T>A	uc001pnz.2	-	1	533	c.212A>T	c.(211-213)TAC>TTC	p.Y71F	DRD2_uc010rwv.1_Missense_Mutation_p.Y71F|DRD2_uc001poa.3_Missense_Mutation_p.Y71F|DRD2_uc001pob.3_Missense_Mutation_p.Y71F|DRD2_uc009yyr.1_Missense_Mutation_p.Y71F	NM_000795	NP_000786	P14416	DRD2_HUMAN	dopamine receptor D2 isoform long	71	Helical; Name=2; (By similarity).				activation of phospholipase C activity by dopamine receptor signaling pathway|adenohypophysis development|adult walking behavior|arachidonic acid secretion|axonogenesis|behavioral response to cocaine|behavioral response to ethanol|branching morphogenesis of a nerve|cerebral cortex GABAergic interneuron migration|circadian regulation of gene expression|elevation of cytosolic calcium ion concentration involved in G-protein signaling coupled to IP3 second messenger|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|intracellular protein kinase cascade|negative regulation of blood pressure|negative regulation of calcium ion transport via voltage-gated calcium channel activity|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of dopamine receptor signaling pathway|negative regulation of protein kinase B signaling cascade|negative regulation of protein secretion|negative regulation of synaptic transmission, glutamatergic|neurological system process involved in regulation of systemic arterial blood pressure|peristalsis|phosphatidylinositol metabolic process|positive regulation of dopamine uptake|positive regulation of growth hormone secretion|positive regulation of neuroblast proliferation|prepulse inhibition|protein localization|regulation of heart rate|regulation of long-term neuronal synaptic plasticity|regulation of potassium ion transport|regulation of sodium ion transport|regulation of synaptic transmission, GABAergic|release of sequestered calcium ion into cytosol|response to amphetamine|response to drug|response to histamine|response to morphine|sensory perception of smell|synapse assembly|temperature homeostasis|visual learning	integral to plasma membrane	dopamine D2 receptor activity|dopamine receptor activity, coupled via Gi/Go|drug binding|potassium channel regulator activity|protein binding			pancreas(1)|skin(1)	2		all_cancers(61;3.91e-16)|all_epithelial(67;2.95e-09)|Melanoma(852;1.46e-05)|all_hematologic(158;0.00014)|Acute lymphoblastic leukemia(157;0.000977)|Breast(348;0.0101)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)|Prostate(24;0.0494)		BRCA - Breast invasive adenocarcinoma(274;5.77e-06)|Epithelial(105;6.66e-05)|all cancers(92;0.000307)|OV - Ovarian serous cystadenocarcinoma(223;0.216)	Acetophenazine(DB01063)|Amantadine(DB00915)|Apomorphine(DB00714)|Aripiprazole(DB01238)|Bromocriptine(DB01200)|Buspirone(DB00490)|Cabergoline(DB00248)|Carphenazine(DB01038)|Chlorpromazine(DB00477)|Chlorprothixene(DB01239)|Cinnarizine(DB00568)|Clozapine(DB00363)|Domperidone(DB01184)|Droperidol(DB00450)|Ergotamine(DB00696)|Flupenthixol(DB00875)|Fluphenazine(DB00623)|Fluspirilene(DB04842)|Haloperidol(DB00502)|Levodopa(DB01235)|Lisuride(DB00589)|Loxapine(DB00408)|Mesoridazine(DB00933)|Metoclopramide(DB01233)|Minaprine(DB00805)|Molindone(DB01618)|Olanzapine(DB00334)|Paliperidone(DB01267)|Pergolide(DB01186)|Perphenazine(DB00850)|Pimozide(DB01100)|Pramipexole(DB00413)|Prochlorperazine(DB00433)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Quetiapine(DB01224)|Remoxipride(DB00409)|Risperidone(DB00734)|Ropinirole(DB00268)|Sertindole(DB06144)|Sulpiride(DB00391)|Thiethylperazine(DB00372)|Thioridazine(DB00679)|Tranylcypromine(DB00752)|Trifluoperazine(DB00831)|Triflupromazine(DB00508)|Ziprasidone(DB00246)|Zuclopenthixol(DB01624)	GACGATCAGGTAGTTGGTGGT	0.637		NA											16	38					0	0	0	0
RNF214	257160	broad.mit.edu	37	11	117153235	117153235	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr11:117153235G>A	uc001pqt.2	+	12	1873	c.1828G>A	c.(1828-1830)GTG>ATG	p.V610M	RNF214_uc001pqu.2_Missense_Mutation_p.V610M|RNF214_uc010rxf.1_Missense_Mutation_p.V455M	NM_207343	NP_997226	Q8ND24	RN214_HUMAN	ring finger protein 214	610							zinc ion binding				0	all_hematologic(175;0.0487)	Breast(348;0.00908)|Medulloblastoma(222;0.0425)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;1.88e-05)|Epithelial(105;0.000397)|all cancers(92;0.00258)		ACATGAGCGGGTGGCAGCAAG	0.522		NA											14	18					0	0	0	0
CEP164	22897	broad.mit.edu	37	11	117253621	117253621	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr11:117253621G>C	uc001prc.2	+	14	1834	c.1687G>C	c.(1687-1689)GTG>CTG	p.V563L	CEP164_uc001prb.2_Missense_Mutation_p.V566L|CEP164_uc010rxk.1_Missense_Mutation_p.V537L|CEP164_uc001prf.2_RNA|CEP164_uc009yzp.1_RNA|CEP164_uc001prg.1_5'Flank	NM_014956	NP_055771	Q9UPV0	CE164_HUMAN	centrosomal protein 164kDa	563	Glu-rich.				cell division|DNA repair|G2/M transition of mitotic cell cycle|mitosis	centriole|cytosol|nucleus				ovary(1)|central_nervous_system(1)	2	all_hematologic(175;0.0487)	Breast(348;0.00908)|Medulloblastoma(222;0.0425)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;4e-05)|Epithelial(105;0.0008)		TGAGGAGAAGGTGGCGGTCAG	0.637		NA											17	20					0	0	0	0
SORL1	6653	broad.mit.edu	37	11	121475024	121475024	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr11:121475024G>A	uc001pxx.2	+	33	4722	c.4642G>A	c.(4642-4644)GCC>ACC	p.A1548T	SORL1_uc010rzp.1_Missense_Mutation_p.A394T|SORL1_uc010rzq.1_Missense_Mutation_p.A163T	NM_003105	NP_003096	Q92673	SORL_HUMAN	sortilin-related receptor containing LDLR class	1548	Extracellular (Potential).|LDL-receptor class A 11.				cholesterol metabolic process|lipid transport|receptor-mediated endocytosis	integral to plasma membrane|low-density lipoprotein particle	low-density lipoprotein particle binding|transmembrane receptor activity			ovary(5)|breast(4)|large_intestine(2)|skin(2)|central_nervous_system(1)|pancreas(1)	15		Breast(109;0.00119)|Medulloblastoma(222;0.0429)|all_neural(223;0.113)		BRCA - Breast invasive adenocarcinoma(274;3.34e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.108)		CGATGAAAAGGCCTGCAGTGG	0.547		NA											20	37					0	0	0	0
OR10G4	390264	broad.mit.edu	37	11	123886995	123886995	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr11:123886995G>T	uc010sac.1	+	1	714	c.714G>T	c.(712-714)CAG>CAT	p.Q238H		NM_001004462	NP_001004462	Q8NGN3	O10G4_HUMAN	olfactory receptor, family 10, subfamily G,	238	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)|central_nervous_system(1)	4		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0401)		GAGCCTTTCAGACCTGTGCCT	0.542		NA											22	57					1.5e-11	1.93e-11	1	0
OR8D2	283160	broad.mit.edu	37	11	124189698	124189698	+	Nonsense_Mutation	SNP	G	G	T			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr11:124189698G>T	uc010sah.1	-	1	396	c.396C>A	c.(394-396)TAC>TAA	p.Y132*		NM_001002918	NP_001002918	Q9GZM6	OR8D2_HUMAN	olfactory receptor, family 8, subfamily D,	132	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|pancreas(1)	3		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0525)		TGACAATATTGTAAAGCAGTG	0.443		NA											11	32					2.81e-09	3.47e-09	1	0
FAM118B	79607	broad.mit.edu	37	11	126110725	126110725	+	Missense_Mutation	SNP	A	A	C			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr11:126110725A>C	uc001qdf.2	+	4	308	c.125A>C	c.(124-126)GAA>GCA	p.E42A	FAM118B_uc009zca.2_Missense_Mutation_p.E46A|FAM118B_uc001qdg.2_Missense_Mutation_p.E42A	NM_024556	NP_078832	Q9BPY3	F118B_HUMAN	hypothetical protein LOC79607	42											0	all_hematologic(175;0.145)	Breast(109;0.00156)|Lung NSC(97;0.00948)|all_lung(97;0.0101)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.15e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0784)		AAGCCTCGAGAACTTGTGCTA	0.443		NA											64	148					0	0	0	0
KCNJ1	3758	broad.mit.edu	37	11	128709440	128709440	+	Silent	SNP	T	T	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr11:128709440T>A	uc001qeo.1	-	2	807	c.756A>T	c.(754-756)GTA>GTT	p.V252V	KCNJ1_uc001qep.1_Silent_p.V233V|KCNJ1_uc001qeq.1_Silent_p.V233V|KCNJ1_uc001qer.1_Silent_p.V233V|KCNJ1_uc001qes.1_Silent_p.V233V	NM_000220	NP_000211	P48048	IRK1_HUMAN	potassium inwardly-rectifying channel J1 isoform	252	Cytoplasmic (By similarity).				excretion	voltage-gated potassium channel complex	ATP binding|inward rectifier potassium channel activity			ovary(3)|breast(1)	4	all_hematologic(175;0.0641)	all_lung(97;4.89e-06)|Lung NSC(97;9.34e-06)|Breast(109;0.00123)|all_hematologic(192;0.00793)|Renal(330;0.0112)|all_neural(223;0.0189)|Medulloblastoma(222;0.0425)		OV - Ovarian serous cystadenocarcinoma(99;4.05e-06)|LUSC - Lung squamous cell carcinoma(976;0.008)|Lung(977;0.00942)	Acetohexamide(DB00414)|Chlorpropamide(DB00672)|Glibenclamide(DB01016)|Gliclazide(DB01120)|Glimepiride(DB00222)|Glipizide(DB01067)|Glycodiazine(DB01382)|Minoxidil(DB00350)|Nateglinide(DB00731)|Repaglinide(DB00912)|Tolazamide(DB00839)|Tolbutamide(DB01124)	CAGCGTCAACTACAAAGTTGA	0.428		NA											40	92					0	0	0	0
OPCML	4978	broad.mit.edu	37	11	132307171	132307171	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr11:132307171G>C	uc001qgs.2	-	4	659	c.609C>G	c.(607-609)AGC>AGG	p.S203R	OPCML_uc001qgu.2_Missense_Mutation_p.S196R|OPCML_uc010sck.1_Missense_Mutation_p.S203R|OPCML_uc001qgt.2_Missense_Mutation_p.S202R|OPCML_uc010scl.1_Missense_Mutation_p.S162R	NM_002545	NP_002536	Q14982	OPCM_HUMAN	opioid binding protein/cell adhesion	203	Ig-like C2-type 2.				cell adhesion|neuron recognition	anchored to membrane|integral to plasma membrane	opioid receptor activity			ovary(2)|skin(1)	3	all_hematologic(175;0.019)	all_cancers(12;5.86e-24)|all_epithelial(12;2.65e-17)|all_lung(97;2.89e-05)|Lung NSC(97;6.16e-05)|Breast(109;0.000126)|Medulloblastoma(222;0.0269)|all_neural(223;0.0326)|Esophageal squamous(93;0.129)		all cancers(11;4.61e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.012)		CGTTCAACGCGCTGCATTCGT	0.542		NA											26	42					0	0	0	0
LEPREL2	10536	broad.mit.edu	37	12	6943184	6943184	+	Nonsense_Mutation	SNP	G	G	T			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr12:6943184G>T	uc001qra.1	+	11	1463	c.1429G>T	c.(1429-1431)GAG>TAG	p.E477*	LEPREL2_uc001qqz.1_Nonsense_Mutation_p.E284*|LEPREL2_uc001qrb.1_Nonsense_Mutation_p.E284*	NM_014262	NP_055077	Q8IVL6	P3H3_HUMAN	leprecan-like 2 precursor	477					negative regulation of cell proliferation	endoplasmic reticulum	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-proline 3-dioxygenase activity				0					L-Proline(DB00172)|Succinic acid(DB00139)|Vitamin C(DB00126)	CACCCCAGCCGAGTGTGGGGT	0.587		NA											28	55					1.18e-12	1.54e-12	1	0
CD163	9332	broad.mit.edu	37	12	7640427	7640427	+	Silent	SNP	T	T	G			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr12:7640427T>G	uc001qsz.3	-	7	1805	c.1677A>C	c.(1675-1677)GTA>GTC	p.V559V	CD163_uc001qta.3_Silent_p.V559V|CD163_uc009zfw.2_Silent_p.V559V	NM_004244	NP_004235	Q86VB7	C163A_HUMAN	CD163 antigen isoform a	559	SRCR 5.|Extracellular (Potential).				acute-phase response	extracellular region|integral to plasma membrane	protein binding|scavenger receptor activity			ovary(6)|pancreas(1)|skin(1)	8						GGCGGGGTGCTACTGGGCAGA	0.502		NA											32	58					0	0	0	0
KLRB1	3820	broad.mit.edu	37	12	9751243	9751243	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr12:9751243G>T	uc010sgt.1	-	4	328	c.266C>A	c.(265-267)CCG>CAG	p.P89Q		NM_002258	NP_002249	Q12918	KLRB1_HUMAN	killer cell lectin-like receptor subfamily B,	89	Extracellular (Potential).				cell surface receptor linked signaling pathway	integral to membrane|plasma membrane	sugar binding|transmembrane receptor activity				0						TAAGAGACCCGGTCTCTCTAA	0.373		NA											32	72					4.32e-10	5.41e-10	1	0
GUCY2C	2984	broad.mit.edu	37	12	14766128	14766128	+	Missense_Mutation	SNP	G	G	A	rs140551603		TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr12:14766128G>A	uc001rcd.2	-	27	3282	c.3145C>T	c.(3145-3147)CGG>TGG	p.R1049W		NM_004963	NP_004954	P25092	GUC2C_HUMAN	guanylate cyclase 2C precursor	1049	Cytoplasmic (Potential).				intracellular signal transduction|receptor guanylyl cyclase signaling pathway	integral to membrane	ATP binding|GTP binding|guanylate cyclase activity|protein binding|protein kinase activity|receptor activity			ovary(4)|skin(2)	6						CTGGCTACCCGTCTGGGTTTT	0.433		NA											74	158					0	0	0	0
ART4	420	broad.mit.edu	37	12	14993877	14993877	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr12:14993877G>T	uc001rcl.1	-	2	721	c.355C>A	c.(355-357)CAC>AAC	p.H119N	ART4_uc009zid.1_Intron|ART4_uc009zie.1_Intron|ART4_uc001rcm.1_Missense_Mutation_p.H119N	NM_021071	NP_066549	Q93070	NAR4_HUMAN	ADP-ribosyltransferase 4 precursor	119					arginine metabolic process|protein ADP-ribosylation	anchored to membrane|plasma membrane	NAD(P)+-protein-arginine ADP-ribosyltransferase activity				0						GCCACAGCGTGTGTGGTAGTC	0.438		NA											44	87					4.19e-23	5.91e-23	1	0
PTPRO	5800	broad.mit.edu	37	12	15654948	15654948	+	Silent	SNP	C	C	G			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr12:15654948C>G	uc001rcv.1	+	5	1230	c.1056C>G	c.(1054-1056)CCC>CCG	p.P352P	PTPRO_uc001rcw.1_Silent_p.P352P|PTPRO_uc001rcu.1_Silent_p.P352P	NM_030667	NP_109592	Q16827	PTPRO_HUMAN	receptor-type protein tyrosine phosphatase O	352	Fibronectin type-III 4.|Extracellular (Potential).					integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			skin(5)|ovary(2)|upper_aerodigestive_tract(1)|lung(1)	9		Hepatocellular(102;0.244)				GGTTACCACCCAAACCACCCA	0.418		NA											21	63					0	0	0	0
SLCO1C1	53919	broad.mit.edu	37	12	20876190	20876190	+	Splice_Site	SNP	T	T	G			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr12:20876190T>G	uc001rej.3	+	10	1541	c.1186_splice	c.e10+2	p.G396_splice	SLCO1C1_uc010sii.1_Splice_Site_p.G396_splice|SLCO1C1_uc010sij.1_Splice_Site_p.G347_splice|SLCO1C1_uc009zip.2_Splice_Site_p.G230_splice|SLCO1C1_uc001rei.2_Splice_Site_p.G396_splice|SLCO1C1_uc010sik.1_Splice_Site_p.G278_splice	NM_017435	NP_059131	Q9NYB5	SO1C1_HUMAN	solute carrier organic anion transporter family,						sodium-independent organic anion transport	integral to membrane|plasma membrane	thyroid hormone transmembrane transporter activity			ovary(5)|pancreas(1)|skin(1)	7	Esophageal squamous(101;0.149)					TTGTGATCGGTATGCTCATCT	0.443		NA											17	40					0	0	0	0
RECQL	5965	broad.mit.edu	37	12	21629893	21629893	+	Missense_Mutation	SNP	T	T	C			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr12:21629893T>C	uc001rex.2	-	9	1249	c.901A>G	c.(901-903)ATT>GTT	p.I301V	RECQL_uc001rey.2_Missense_Mutation_p.I301V	NM_032941	NP_116559	P46063	RECQ1_HUMAN	RecQ protein-like	301	Helicase C-terminal.				DNA recombination|DNA repair|DNA replication	nucleus	ATP binding|ATP-dependent 3'-5' DNA helicase activity|DNA strand annealing activity|protein binding			ovary(1)|lung(1)	2						ATATCCTCAATAAAATCTTCA	0.338		NA						Direct_reversal_of_damage|Other_identified_genes_with_known_or_suspected_DNA_repair_function					13	39					0	0	0	0
PPFIBP1	8496	broad.mit.edu	37	12	27844781	27844781	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr12:27844781G>C	uc001ric.1	+	27	3180	c.2803G>C	c.(2803-2805)GGA>CGA	p.G935R	PPFIBP1_uc010sjr.1_Missense_Mutation_p.G766R|PPFIBP1_uc001rib.1_Missense_Mutation_p.G929R|PPFIBP1_uc001ria.2_Missense_Mutation_p.G904R|PPFIBP1_uc001rid.1_Missense_Mutation_p.G782R|PPFIBP1_uc001rif.1_Missense_Mutation_p.G442R	NM_003622	NP_003613	Q86W92	LIPB1_HUMAN	PTPRF interacting protein binding protein 1	935					cell adhesion	plasma membrane	protein binding		PPFIBP1/ALK(3)	soft_tissue(3)|kidney(1)|skin(1)	5	Lung SC(9;0.0873)					ACAGGCATCAGGAAGTGCATC	0.403		NA											38	81					0	0	0	0
KIF21A	55605	broad.mit.edu	37	12	39720119	39720119	+	Silent	SNP	T	T	C			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr12:39720119T>C	uc001rly.2	-	25	3494	c.3348A>G	c.(3346-3348)GTA>GTG	p.V1116V	KIF21A_uc001rlv.2_Silent_p.V121V|KIF21A_uc001rlw.2_Silent_p.V433V|KIF21A_uc001rlx.2_Silent_p.V1103V|KIF21A_uc001rlz.2_Silent_p.V1080V|KIF21A_uc010skl.1_Silent_p.V1096V	NM_017641	NP_060111	Q7Z4S6	KI21A_HUMAN	kinesin family member 21A	1116					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(4)|pancreas(1)|lung(1)|skin(1)	7		Lung NSC(34;0.179)|all_lung(34;0.213)				TACTATCCTCTACATTTTCTA	0.358		NA											11	35					0	0	0	0
LRRK2	120892	broad.mit.edu	37	12	40707845	40707845	+	Silent	SNP	G	G	C			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr12:40707845G>C	uc001rmg.3	+	32	4729	c.4608G>C	c.(4606-4608)TCG>TCC	p.S1536S	LRRK2_uc009zjw.2_Silent_p.S374S|LRRK2_uc001rmi.2_Silent_p.S369S	NM_198578	NP_940980	Q5S007	LRRK2_HUMAN	leucine-rich repeat kinase 2	1536					activation of MAPKK activity|determination of adult lifespan|exploration behavior|intracellular distribution of mitochondria|negative regulation of branching morphogenesis of a nerve|negative regulation of dendritic spine morphogenesis|negative regulation of neuroblast proliferation|negative regulation of neuron maturation|neuromuscular junction development|neuron death|peptidyl-serine phosphorylation|positive regulation of autophagy|positive regulation of dopamine receptor signaling pathway|positive regulation of programmed cell death|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of protein ubiquitination|protein autophosphorylation|regulation of kidney size|regulation of locomotion|regulation of membrane potential|response to oxidative stress|small GTPase mediated signal transduction|tangential migration from the subventricular zone to the olfactory bulb	external side of mitochondrial outer membrane	ATP binding|GTP binding|GTP-dependent protein kinase activity|GTPase activator activity|MAP kinase kinase activity|protein homodimerization activity|tubulin binding			ovary(12)|stomach(5)|upper_aerodigestive_tract(2)|lung(2)|large_intestine(1)|urinary_tract(1)|pancreas(1)	24	all_cancers(12;0.00108)|Breast(8;0.218)	Lung NSC(34;0.0942)|all_lung(34;0.11)				TCATTTTATCGGAGCGTAAAA	0.373		NA											13	37					0	0	0	0
NELL2	4753	broad.mit.edu	37	12	45173741	45173741	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr12:45173741G>A	uc001rog.2	-	4	995	c.400C>T	c.(400-402)CAC>TAC	p.H134Y	NELL2_uc001rof.3_Missense_Mutation_p.H133Y|NELL2_uc001roh.2_Missense_Mutation_p.H134Y|NELL2_uc009zkd.2_Missense_Mutation_p.H133Y|NELL2_uc010skz.1_Missense_Mutation_p.H184Y|NELL2_uc010sla.1_Missense_Mutation_p.H157Y|NELL2_uc001roi.1_Missense_Mutation_p.H134Y|NELL2_uc010slb.1_Missense_Mutation_p.H133Y|NELL2_uc001roj.2_Missense_Mutation_p.H134Y	NM_001145108	NP_001138580	Q99435	NELL2_HUMAN	NEL-like protein 2 isoform b precursor	134	TSP N-terminal.				cell adhesion	extracellular region	calcium ion binding|protein binding|structural molecule activity			skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	4	Lung SC(27;0.192)	Lung NSC(34;0.144)		GBM - Glioblastoma multiforme(48;0.092)		TGAGGGCGGTGACTGCCTGAG	0.473		NA											32	79					0	0	0	0
KRT6C	286887	broad.mit.edu	37	12	52862855	52862855	+	Silent	SNP	G	G	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr12:52862855G>A	uc001sal.3	-	9	1734	c.1686C>T	c.(1684-1686)TAC>TAT	p.Y562Y		NM_173086	NP_775109	P48668	K2C6C_HUMAN	keratin 6C	562	Tail.				cytoskeleton organization	keratin filament	structural molecule activity			ovary(2)	2				BRCA - Breast invasive adenocarcinoma(357;0.0828)		TTTAGTGCTTGTAGCTCTTCC	0.612		NA											4	50					0	0	0	0
ANKRD52	283373	broad.mit.edu	37	12	56641850	56641850	+	Silent	SNP	G	G	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr12:56641850G>A	uc001skm.3	-	18	2025	c.1935C>T	c.(1933-1935)CTC>CTT	p.L645L		NM_173595	NP_775866	Q8NB46	ANR52_HUMAN	ankyrin repeat domain 52	645	ANK 18.						protein binding			ovary(2)	2						GCTCCTTGATGAGGGCAGAGG	0.632		NA											11	19					0	0	0	0
GNS	2799	broad.mit.edu	37	12	65130829	65130829	+	Silent	SNP	T	T	C			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr12:65130829T>C	uc001ssg.3	-	9	1223	c.1053A>G	c.(1051-1053)CCA>CCG	p.P351P	GNS_uc001ssf.2_Silent_p.P295P|GNS_uc010ssq.1_Silent_p.P383P|GNS_uc010ssr.1_Silent_p.P331P	NM_002076	NP_002067	P15586	GNS_HUMAN	glucosamine (N-acetyl)-6-sulfatase precursor	351						lysosome	metal ion binding|N-acetylglucosamine-6-sulfatase activity|protein binding			central_nervous_system(1)	1	Lung NSC(1;7.25e-14)|all_lung(1;1.25e-12)		LUAD - Lung adenocarcinoma(6;0.115)	GBM - Glioblastoma multiforme(28;0.0435)		GAACCAACAGTGGAACTTTGA	0.453		NA											16	51					0	0	0	0
PPFIA2	8499	broad.mit.edu	37	12	81768458	81768458	+	Silent	SNP	A	A	T			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr12:81768458A>T	uc001szo.1	-	11	1382	c.1221T>A	c.(1219-1221)CCT>CCA	p.P407P	PPFIA2_uc010sue.1_Intron|PPFIA2_uc010sug.1_RNA|PPFIA2_uc010suh.1_RNA|PPFIA2_uc010sui.1_RNA|PPFIA2_uc010suj.1_RNA|PPFIA2_uc009zsi.1_RNA	NM_003625	NP_003616	B7Z663	B7Z663_HUMAN	PTPRF interacting protein alpha 2	333										ovary(3)|lung(2)|pancreas(1)	6						CCTCTACTTCAGGCAAGGTTT	0.433		NA											39	61					0	0	0	0
UHRF1BP1L	23074	broad.mit.edu	37	12	100492321	100492321	+	Splice_Site	SNP	T	T	C			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr12:100492321T>C	uc001tgq.2	-	5	568	c.339_splice	c.e5-1	p.S113_splice	UHRF1BP1L_uc001tgr.2_Splice_Site_p.S113_splice	NM_015054	NP_055869	A0JNW5	UH1BL_HUMAN	UHRF1 (ICBP90) binding protein 1-like isoform a											ovary(2)	2						CCGTATTCACTGGAAAAACAA	0.259		NA											16	23					0	0	0	0
NT5DC3	51559	broad.mit.edu	37	12	104187036	104187036	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr12:104187036C>T	uc010swe.1	-	9	966	c.925G>A	c.(925-927)GGG>AGG	p.G309R		NM_001031701	NP_001026871	Q86UY8	NT5D3_HUMAN	5'-nucleotidase domain containing 3	309							hydrolase activity|metal ion binding			ovary(2)|skin(1)	3						TAACTCATCCCTTTGTCCCTA	0.418		NA											63	167					0	0	0	0
SLC41A2	84102	broad.mit.edu	37	12	105321903	105321903	+	Missense_Mutation	SNP	T	T	G			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr12:105321903T>G	uc001tla.2	-	1	570	c.403A>C	c.(403-405)ATA>CTA	p.I135L		NM_032148	NP_115524	Q96JW4	S41A2_HUMAN	solute carrier family 41, member 2	135	Extracellular.					integral to membrane|plasma membrane	magnesium ion transmembrane transporter activity			ovary(1)|skin(1)	2						TCACTAGATATATCTTCATCT	0.393		NA											34	75					0	0	0	0
NUAK1	9891	broad.mit.edu	37	12	106461453	106461453	+	Silent	SNP	G	G	T			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr12:106461453G>T	uc001tlj.1	-	7	2493	c.1113C>A	c.(1111-1113)TCC>TCA	p.S371S		NM_014840	NP_055655	O60285	NUAK1_HUMAN	AMPK-related protein kinase 5	371							ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			ovary(1)|central_nervous_system(1)	2						TCTCTTTCTTGGATTTCTTCA	0.547		NA											32	68					1.46e-13	1.93e-13	1	0
WSCD2	9671	broad.mit.edu	37	12	108603974	108603974	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr12:108603974G>C	uc001tms.2	+	4	1318	c.574G>C	c.(574-576)GAG>CAG	p.E192Q	WSCD2_uc001tmt.2_Missense_Mutation_p.E192Q	NM_014653	NP_055468	Q2TBF2	WSCD2_HUMAN	WSC domain containing 2	192	WSC 1.					integral to membrane				ovary(1)|large_intestine(1)|breast(1)	3						GAACGTGAGCGAGGCAGAGTG	0.677		NA											8	26					0	0	0	0
C12orf51	283450	broad.mit.edu	37	12	112673511	112673511	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr12:112673511G>A	uc009zwc.2	-	29	4274	c.4256C>T	c.(4255-4257)CCG>CTG	p.P1419L		NM_001109662	NP_001103132			chromosome 12 open reading frame 51											ovary(1)|lung(1)	2						CTTTGGAGACGGGCGTTGGTC	0.562		NA											11	21					0	0	0	0
C12orf51	283450	broad.mit.edu	37	12	112684766	112684766	+	Silent	SNP	G	G	C			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr12:112684766G>C	uc009zwc.2	-	22	3204	c.3186C>G	c.(3184-3186)GTC>GTG	p.V1062V		NM_001109662	NP_001103132			chromosome 12 open reading frame 51											ovary(1)|lung(1)	2						CTGCGATGGTGACATGCAGCA	0.493		NA											22	24					0	0	0	0
RASAL1	8437	broad.mit.edu	37	12	113543582	113543582	+	Silent	SNP	G	G	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr12:113543582G>A	uc001tum.1	-	17	2057	c.1764C>T	c.(1762-1764)TTC>TTT	p.F588F	RASAL1_uc010syp.1_Silent_p.F589F|RASAL1_uc001tul.2_Silent_p.F588F|RASAL1_uc001tun.1_Silent_p.F590F|RASAL1_uc010syq.1_Silent_p.F589F|RASAL1_uc001tuo.3_Silent_p.F589F	NM_004658	NP_004649	O95294	RASL1_HUMAN	RAS protein activator like 1	588	PH.				intracellular signal transduction|negative regulation of Ras protein signal transduction	cytoplasm|intrinsic to internal side of plasma membrane	metal ion binding|phospholipid binding|Ras GTPase activator activity			ovary(2)|skin(2)	4						AGCGCTTCTTGAAGGCAAAGC	0.637		NA											31	54					0	0	0	0
IQCD	115811	broad.mit.edu	37	12	113645397	113645397	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr12:113645397C>T	uc001tuv.1	-	2	997	c.575G>A	c.(574-576)GGT>GAT	p.G192D	IQCD_uc001tuu.2_Missense_Mutation_p.G192D	NM_138451	NP_612460	Q96DY2	IQCD_HUMAN	IQ motif containing D	192										ovary(1)	1						AAACAGGAAACCACGGAGCTC	0.473		NA											22	66					0	0	0	0
SRRM4	84530	broad.mit.edu	37	12	119563220	119563220	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr12:119563220C>A	uc001txa.1	+	7	842	c.550C>A	c.(550-552)CGC>AGC	p.R184S		NM_194286	NP_919262	A7MD48	SRRM4_HUMAN	KIAA1853 protein	184	Ser-rich.				cell differentiation|mRNA processing|nervous system development|regulation of RNA splicing|RNA splicing	nucleus	mRNA binding			ovary(2)	2						TCACCGCCACCGCCATCACCG	0.478		NA											17	27					6.94e-10	8.67e-10	1	0
COQ5	84274	broad.mit.edu	37	12	120947835	120947835	+	Silent	SNP	G	G	C			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr12:120947835G>C	uc001tyn.2	-	4	686	c.666C>G	c.(664-666)GTC>GTG	p.V222V	COQ5_uc001tyo.2_Silent_p.V141V|COQ5_uc010szj.1_Silent_p.V148V	NM_032314	NP_115690	Q5HYK3	COQ5_HUMAN	coenzyme Q5 homolog, methyltransferase	222					ubiquinone biosynthetic process	mitochondrion	methyltransferase activity			ovary(1)	1	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					CAATGTGTGTGACATTCCGGA	0.438		NA											15	37					0	0	0	0
TUBA3C	7278	broad.mit.edu	37	13	19751082	19751082	+	Nonsense_Mutation	SNP	G	G	T	rs148928584		TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr13:19751082G>T	uc009zzj.2	-	4	1090	c.1041C>A	c.(1039-1041)TGC>TGA	p.C347*		NM_006001	NP_005992	Q13748	TBA3C_HUMAN	tubulin, alpha 3c	347					'de novo' posttranslational protein folding|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|protein binding|structural molecule activity			ovary(3)|skin(2)	5		all_cancers(29;1.31e-20)|all_epithelial(30;1.59e-20)|all_lung(29;6.91e-20)|Lung NSC(5;9.25e-17)|Hepatocellular(1;0.0207)|Lung SC(185;0.0262)|Ovarian(182;0.162)		all cancers(112;6.78e-06)|Epithelial(112;3.79e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00172)|Lung(94;0.0186)|LUSC - Lung squamous cell carcinoma(192;0.108)		ATCCAGTTGGGCACCAATCTA	0.527		NA											13	19					1.15e-07	1.37e-07	1	0
BRCA2	675	broad.mit.edu	37	13	32907114	32907114	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr13:32907114G>T	uc001uub.1	+	10	1726	c.1499G>T	c.(1498-1500)GGT>GTT	p.G500V	BRCA2_uc001uua.1_Missense_Mutation_p.G377V	NM_000059	NP_000050	P51587	BRCA2_HUMAN	breast cancer 2, early onset	500					cell cycle cytokinesis|centrosome duplication|double-strand break repair via homologous recombination|negative regulation of mammary gland epithelial cell proliferation|nucleotide-excision repair|positive regulation of transcription, DNA-dependent|regulation of S phase of mitotic cell cycle	BRCA2-MAGE-D1 complex|centrosome|nucleoplasm|stored secretory granule	gamma-tubulin binding|H3 histone acetyltransferase activity|H4 histone acetyltransferase activity|protease binding|single-stranded DNA binding			ovary(20)|endometrium(8)|lung(7)|breast(7)|oesophagus(5)|large_intestine(4)|central_nervous_system(3)|pancreas(3)|skin(2)|upper_aerodigestive_tract(1)|cervix(1)|salivary_gland(1)|liver(1)|kidney(1)	64		Lung SC(185;0.0262)		all cancers(112;7.13e-07)|Epithelial(112;1.59e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.000732)|BRCA - Breast invasive adenocarcinoma(63;0.0291)|GBM - Glioblastoma multiforme(144;0.0704)		TCATTTCAGGGTATCAAAAAG	0.363		NA	D|Mis|N|F|S		breast|ovarian|pancreatic	breast|ovarian|pancreatic|leukemia  (FANCB|FANCD1)		Direct_reversal_of_damage|Homologous_recombination	Fanconi_Anemia_type_D1_bi-allelic_BRCA2_mutations|Fanconi_Anemia|Pancreatic_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_BRCA2_type|Hereditary_Prostate_Cancer|Li-Fraumeni_syndrome	TCGA Ovarian(8;0.087)			25	33					4.27e-12	5.54e-12	1	0
FREM2	341640	broad.mit.edu	37	13	39343823	39343823	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr13:39343823G>T	uc001uwv.2	+	4	5828	c.5519G>T	c.(5518-5520)CGG>CTG	p.R1840L	FREM2_uc001uww.2_5'UTR	NM_207361	NP_997244	Q5SZK8	FREM2_HUMAN	FRAS1-related extracellular matrix protein 2	1840	Calx-beta 1.|Extracellular (Potential).				cell communication|homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(7)|pancreas(1)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|skin(1)	11		Lung NSC(96;1.04e-07)|Prostate(109;0.00384)|Breast(139;0.00396)|Lung SC(185;0.0565)|Hepatocellular(188;0.114)		all cancers(112;3.32e-07)|Epithelial(112;1.66e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00154)|BRCA - Breast invasive adenocarcinoma(63;0.00631)|GBM - Glioblastoma multiforme(144;0.0312)		TGGCGAGTGCGGATCCTGAGT	0.537		NA											19	21					2.39e-15	3.23e-15	1	0
FREM2	341640	broad.mit.edu	37	13	39425200	39425200	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr13:39425200G>C	uc001uwv.2	+	10	7006	c.6697G>C	c.(6697-6699)GGT>CGT	p.G2233R	FREM2_uc001uww.2_Missense_Mutation_p.G319R	NM_207361	NP_997244	Q5SZK8	FREM2_HUMAN	FRAS1-related extracellular matrix protein 2	2233	Extracellular (Potential).				cell communication|homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(7)|pancreas(1)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|skin(1)	11		Lung NSC(96;1.04e-07)|Prostate(109;0.00384)|Breast(139;0.00396)|Lung SC(185;0.0565)|Hepatocellular(188;0.114)		all cancers(112;3.32e-07)|Epithelial(112;1.66e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00154)|BRCA - Breast invasive adenocarcinoma(63;0.00631)|GBM - Glioblastoma multiforme(144;0.0312)		GGCTGCAGTTGGTGAACAAAA	0.438		NA											16	24					0	0	0	0
DIAPH3	81624	broad.mit.edu	37	13	60590252	60590252	+	Silent	SNP	C	C	T			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr13:60590252C>T	uc001vht.2	-	6	873	c.654G>A	c.(652-654)GGG>GGA	p.G218G	DIAPH3_uc001vhu.2_5'Flank|DIAPH3_uc001vhw.1_Silent_p.G207G|DIAPH3_uc010aed.1_Silent_p.G172G|DIAPH3_uc010aee.1_Silent_p.G148G|uc001vhx.2_Intron|uc001vhy.2_Intron	NM_001042517	NP_001035982	Q9NSV4	DIAP3_HUMAN	diaphanous homolog 3 isoform a	218	GBD/FH3.				actin cytoskeleton organization		actin binding|Rho GTPase binding			ovary(2)	2		Breast(118;0.052)|Prostate(109;0.103)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;2.77e-05)		ATAATCCAAGCCCTTCATGTC	0.313		NA											7	15					0	0	0	0
MYO16	23026	broad.mit.edu	37	13	109318423	109318423	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr13:109318423C>A	uc001vqt.1	+	2	278	c.152C>A	c.(151-153)GCG>GAG	p.A51E	MYO16_uc010agk.1_Missense_Mutation_p.A73E	NM_015011	NP_055826	Q9Y6X6	MYO16_HUMAN	myosin heavy chain Myr 8	51					cerebellum development|negative regulation of cell proliferation|negative regulation of S phase of mitotic cell cycle	myosin complex|nucleoplasm|perinuclear region of cytoplasm|plasma membrane	actin filament binding|ATP binding|motor activity	p.A51A(1)		ovary(6)|large_intestine(1)|kidney(1)|breast(1)|central_nervous_system(1)	10	all_lung(23;0.000332)|all_neural(89;0.00294)|Medulloblastoma(90;0.00596)|Lung NSC(43;0.00751)|Lung SC(71;0.104)		BRCA - Breast invasive adenocarcinoma(86;0.19)|all cancers(43;0.201)			CTGAAGCATGCGAAGAATCCG	0.483		NA											12	12					3.07e-06	3.54e-06	1	0
POTEG	404785	broad.mit.edu	37	14	19553682	19553682	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr14:19553682C>T	uc001vuz.1	+	1	318	c.266C>T	c.(265-267)TCT>TTT	p.S89F	POTEG_uc001vva.1_RNA|POTEG_uc010ahc.1_RNA	NM_001005356	NP_001005356	Q6S5H5	POTEG_HUMAN	POTE ankyrin domain family, member G	89										ovary(1)	1						CACGACGACTCTGCTATGAAG	0.617		NA											23	531					0	0	0	0
POTEG	404785	broad.mit.edu	37	14	19553819	19553819	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr14:19553819G>A	uc001vuz.1	+	1	455	c.403G>A	c.(403-405)GTC>ATC	p.V135I	POTEG_uc001vva.1_RNA|POTEG_uc010ahc.1_RNA	NM_001005356	NP_001005356	Q6S5H5	POTEG_HUMAN	POTE ankyrin domain family, member G	135										ovary(1)	1						GAGGTACCACGTCCGTCGAGA	0.582		NA											11	285					0	0	0	0
FOXG1	2290	broad.mit.edu	37	14	29236541	29236541	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr14:29236541G>T	uc001wqe.2	+	1	255	c.56G>T	c.(55-57)AGC>ATC	p.S19I		NM_005249	NP_005240	P55316	FOXG1_HUMAN	forkhead box G1	19					axon midline choice point recognition|central nervous system neuron development|dorsal/ventral pattern formation|embryo development ending in birth or egg hatching|hindbrain development|inner ear morphogenesis|negative regulation of neuron differentiation|negative regulation of transcription, DNA-dependent|nonmotile primary cilium assembly|nose development|positive regulation of cell cycle|positive regulation of neuroblast proliferation|positive regulation of transcription from RNA polymerase II promoter|regulation of mitotic cell cycle|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			ovary(2)|lung(2)	4			LUAD - Lung adenocarcinoma(48;0.011)|Lung(238;0.0575)	GBM - Glioblastoma multiforme(265;0.00413)		TCCTCGTTCAGCATCAACAGC	0.393		NA											7	18					1.13e-05	1.28e-05	1	0
PRKD1	5587	broad.mit.edu	37	14	30194823	30194823	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr14:30194823G>A	uc001wqh.2	-	2	503	c.322C>T	c.(322-324)CCT>TCT	p.P108S		NM_002742	NP_002733	Q15139	KPCD1_HUMAN	protein kinase D1	108					cell proliferation|intracellular signal transduction|sphingolipid metabolic process	cytosol|integral to plasma membrane	ATP binding|metal ion binding|protein binding|protein kinase C activity			lung(3)|large_intestine(2)|ovary(2)|skin(1)	8	Hepatocellular(127;0.0604)		LUAD - Lung adenocarcinoma(48;0.00527)|Lung(238;0.0252)	GBM - Glioblastoma multiforme(265;0.00888)		TCAGAGGTAGGGTCATGGCGA	0.413		NA											16	45					0	0	0	0
CLEC14A	161198	broad.mit.edu	37	14	38724494	38724494	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr14:38724494G>A	uc001wum.1	-	1	1081	c.734C>T	c.(733-735)CCC>CTC	p.P245L		NM_175060	NP_778230	Q86T13	CLC14_HUMAN	C-type lectin domain family 14, member A	245	Extracellular (Potential).|EGF-like.					integral to membrane	sugar binding			ovary(3)|skin(1)	4	Hepatocellular(127;0.213)|Esophageal squamous(585;0.22)		Lung(238;3.93e-06)|LUAD - Lung adenocarcinoma(48;2.62e-05)|Epithelial(34;0.187)	GBM - Glioblastoma multiforme(112;0.00439)		CCCGGGGCAGGGACACAACAC	0.617		NA											46	120					0	0	0	0
PLEKHG3	26030	broad.mit.edu	37	14	65208417	65208417	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr14:65208417G>C	uc001xho.1	+	16	2451	c.2182G>C	c.(2182-2184)GAA>CAA	p.E728Q	PLEKHG3_uc001xhn.1_Missense_Mutation_p.E672Q|PLEKHG3_uc001xhp.2_Missense_Mutation_p.E849Q|PLEKHG3_uc010aqh.1_Missense_Mutation_p.E270Q|PLEKHG3_uc001xhq.1_Missense_Mutation_p.E233Q	NM_015549	NP_056364	A1L390	PKHG3_HUMAN	pleckstrin homology domain containing, family G,	728				YYENAEHHDAGFSV -> WWPHCTPASCSSPT (in Ref. 2; AAH04298).	regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			skin(1)	1				all cancers(60;0.00802)|OV - Ovarian serous cystadenocarcinoma(108;0.0109)|BRCA - Breast invasive adenocarcinoma(234;0.0485)		TGAAAATGCAGAACACCATGA	0.527		NA											22	84					0	0	0	0
ZFYVE26	23503	broad.mit.edu	37	14	68274302	68274302	+	Silent	SNP	C	C	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr14:68274302C>A	uc001xka.2	-	5	838	c.699G>T	c.(697-699)GGG>GGT	p.G233G	ZFYVE26_uc010tsz.1_RNA|ZFYVE26_uc001xkc.3_Silent_p.G233G|ZFYVE26_uc010tta.1_Silent_p.G233G	NM_015346	NP_056161	Q68DK2	ZFY26_HUMAN	zinc finger, FYVE domain containing 26	233					cell cycle|cell death|cytokinesis|double-strand break repair via homologous recombination	centrosome|midbody	metal ion binding|phosphatidylinositol-3-phosphate binding|protein binding			ovary(9)|breast(2)	11				all cancers(60;0.000763)|OV - Ovarian serous cystadenocarcinoma(108;0.0011)|BRCA - Breast invasive adenocarcinoma(234;0.0115)		GCAACTCAACCCCAAGTGGTT	0.637		NA											16	31					2.32e-05	2.59e-05	1	0
CYP46A1	10858	broad.mit.edu	37	14	100172989	100172989	+	Nonsense_Mutation	SNP	T	T	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr14:100172989T>A	uc001ygo.2	+	6	449	c.449T>A	c.(448-450)TTG>TAG	p.L150*	CYP46A1_uc001ygn.1_Nonsense_Mutation_p.L112*|CYP46A1_uc001ygp.2_5'UTR	NM_006668	NP_006659	Q9Y6A2	CP46A_HUMAN	cytochrome P450, family 46	150					bile acid biosynthetic process|cholesterol catabolic process|nervous system development|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	cholesterol 24-hydroxylase activity|electron carrier activity|heme binding|steroid hydroxylase activity				0		Melanoma(154;0.0866)|all_epithelial(191;0.179)				TCCAGCTCCTTGGTTAGCTTA	0.547		NA											22	44					0	0	0	0
AHNAK2	113146	broad.mit.edu	37	14	105411241	105411241	+	Missense_Mutation	SNP	A	A	C			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr14:105411241A>C	uc010axc.1	-	7	10667	c.10547T>G	c.(10546-10548)CTC>CGC	p.L3516R	AHNAK2_uc001ypx.2_Missense_Mutation_p.L3416R	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	3516						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			AGTGGCCTTGAGGTCCCCCTG	0.667		NA											49	125					0	0	0	0
OR4M2	390538	broad.mit.edu	37	15	22369024	22369024	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr15:22369024G>T	uc010tzu.1	+	1	449	c.449G>T	c.(448-450)AGG>ATG	p.R150M	LOC727924_uc001yua.2_RNA|LOC727924_uc001yub.1_Intron|OR4N4_uc001yuc.1_Intron	NM_001004719	NP_001004719	Q8NGB6	OR4M2_HUMAN	olfactory receptor, family 4, subfamily M,	150	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		all_cancers(20;1.94e-20)|all_epithelial(15;3.94e-18)|Lung NSC(15;8.53e-15)|all_lung(15;2.87e-14)|Breast(32;0.00519)|Colorectal(260;0.101)	GBM - Glioblastoma multiforme(6;0.124)	all cancers(64;1.64e-11)|Epithelial(43;5.81e-10)|BRCA - Breast invasive adenocarcinoma(123;0.000255)|Kidney(6;0.00736)|KIRC - Kidney renal clear cell carcinoma(6;0.0135)|GBM - Glioblastoma multiforme(186;0.0963)		CTCTCCTGGAGGGGGGGCTTC	0.502		NA											49	313					1.75e-23	2.47e-23	1	0
OR4N4	283694	broad.mit.edu	37	15	22382647	22382647	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr15:22382647C>T	uc001yuc.1	+	7	1156	c.175C>T	c.(175-177)CTC>TTC	p.L59F	LOC727924_uc001yub.1_RNA|OR4N4_uc010tzv.1_Missense_Mutation_p.L59F	NM_001005241	NP_001005241	Q8N0Y3	OR4N4_HUMAN	olfactory receptor, family 4, subfamily N,	59	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(4)|skin(1)	5		all_cancers(20;1.94e-20)|all_epithelial(15;3.94e-18)|Lung NSC(15;8.53e-15)|all_lung(15;2.87e-14)|Breast(32;0.00519)|Colorectal(260;0.101)	GBM - Glioblastoma multiforme(6;0.124)	all cancers(64;1.64e-11)|Epithelial(43;5.81e-10)|BRCA - Breast invasive adenocarcinoma(123;0.000255)|Kidney(6;0.00736)|KIRC - Kidney renal clear cell carcinoma(6;0.0135)|GBM - Glioblastoma multiforme(186;0.0963)		CACAGCCCCCCTCTATTTATT	0.453		NA											48	141					0	0	0	0
OR4N4	283694	broad.mit.edu	37	15	22382715	22382715	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr15:22382715G>A	uc001yuc.1	+	7	1224	c.243G>A	c.(241-243)ATG>ATA	p.M81I	LOC727924_uc001yub.1_RNA|OR4N4_uc010tzv.1_Missense_Mutation_p.M81I	NM_001005241	NP_001005241	Q8N0Y3	OR4N4_HUMAN	olfactory receptor, family 4, subfamily N,	81	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(4)|skin(1)	5		all_cancers(20;1.94e-20)|all_epithelial(15;3.94e-18)|Lung NSC(15;8.53e-15)|all_lung(15;2.87e-14)|Breast(32;0.00519)|Colorectal(260;0.101)	GBM - Glioblastoma multiforme(6;0.124)	all cancers(64;1.64e-11)|Epithelial(43;5.81e-10)|BRCA - Breast invasive adenocarcinoma(123;0.000255)|Kidney(6;0.00736)|KIRC - Kidney renal clear cell carcinoma(6;0.0135)|GBM - Glioblastoma multiforme(186;0.0963)		CTCCCAGGATGTTGGTGGACT	0.517		NA											28	121					0	0	0	0
OR4N4	283694	broad.mit.edu	37	15	22383416	22383416	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr15:22383416G>T	uc001yuc.1	+	7	1925	c.944G>T	c.(943-945)AGA>ATA	p.R315I	LOC727924_uc001yub.1_RNA|OR4N4_uc010tzv.1_Missense_Mutation_p.R315I	NM_001005241	NP_001005241	Q8N0Y3	OR4N4_HUMAN	olfactory receptor, family 4, subfamily N,	315	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(4)|skin(1)	5		all_cancers(20;1.94e-20)|all_epithelial(15;3.94e-18)|Lung NSC(15;8.53e-15)|all_lung(15;2.87e-14)|Breast(32;0.00519)|Colorectal(260;0.101)	GBM - Glioblastoma multiforme(6;0.124)	all cancers(64;1.64e-11)|Epithelial(43;5.81e-10)|BRCA - Breast invasive adenocarcinoma(123;0.000255)|Kidney(6;0.00736)|KIRC - Kidney renal clear cell carcinoma(6;0.0135)|GBM - Glioblastoma multiforme(186;0.0963)		TTTATAATAAGAAACTGAGAA	0.254		NA											11	21					6.4e-05	7.08e-05	1	0
MAGEL2	54551	broad.mit.edu	37	15	23890799	23890799	+	Silent	SNP	G	G	T			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr15:23890799G>T	uc001ywj.3	-	1	377	c.282C>A	c.(280-282)CCC>CCA	p.P94P		NM_019066	NP_061939			MAGE-like protein 2												0		all_cancers(20;1.78e-24)|all_epithelial(15;7.75e-22)|Lung NSC(15;2.96e-18)|all_lung(15;2.8e-17)|Breast(32;0.000625)|Colorectal(260;0.14)		all cancers(64;1.84e-06)|Epithelial(43;1.2e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00177)		CCGGGGGTCCGGGCTGGGCCT	0.652		NA											3	8					0.004672	0.0049279	1	0
GABRA5	2558	broad.mit.edu	37	15	27160007	27160007	+	Missense_Mutation	SNP	C	C	G	rs140643363	by1000genomes	TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr15:27160007C>G	uc001zbd.1	+	8	894	c.555C>G	c.(553-555)CAC>CAG	p.H185Q	GABRB3_uc001zbb.2_Intron	NM_000810	NP_000801	P31644	GBRA5_HUMAN	gamma-aminobutyric acid A receptor, alpha 5	185	Extracellular (Potential).				gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity			ovary(1)	1		all_lung(180;4.59e-13)|Breast(32;0.000563)|Colorectal(260;0.227)		all cancers(64;1.45e-08)|Epithelial(43;4.96e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0232)|Lung(196;0.182)	Alprazolam(DB00404)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	TGGATGCGCACGCTTGCCCTC	0.433		NA											17	18					0	0	0	0
C15orf55	256646	broad.mit.edu	37	15	34640812	34640812	+	Missense_Mutation	SNP	A	A	T			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr15:34640812A>T	uc001zif.2	+	2	814	c.659A>T	c.(658-660)TAC>TTC	p.Y220F	C15orf55_uc010ucc.1_Missense_Mutation_p.Y248F|C15orf55_uc010ucd.1_Missense_Mutation_p.Y238F	NM_175741	NP_786883	Q86Y26	NUT_HUMAN	nuclear protein in testis	220						cytoplasm|nucleus			BRD4_ENST00000263377/C15orf55(24)|BRD3/C15orf55(3)	midline_organs(25)|ovary(2)|lung(2)|skin(1)	30		all_lung(180;2.78e-08)		all cancers(64;4.53e-18)|GBM - Glioblastoma multiforme(113;8.29e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0249)		TGGCAGCGTTACAAAGCCTTG	0.512		NA	T	BRD3|BRD4	lethal midline carcinoma								33	33					0	0	0	0
MAP1A	4130	broad.mit.edu	37	15	43821049	43821049	+	Missense_Mutation	SNP	T	T	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr15:43821049T>A	uc001zrt.2	+	4	7845	c.7378T>A	c.(7378-7380)TCC>ACC	p.S2460T		NM_002373	NP_002364	P78559	MAP1A_HUMAN	microtubule-associated protein 1A	2460						cytoplasm|microtubule|microtubule associated complex	protein binding|structural molecule activity			ovary(3)|breast(3)|pancreas(2)|skin(1)	9		all_cancers(109;1.03e-14)|all_epithelial(112;2.23e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.05e-06)	Estramustine(DB01196)	TCTGCCCCCATCCATAGATGA	0.662		NA											25	16					0	0	0	0
MYO5C	55930	broad.mit.edu	37	15	52532055	52532055	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr15:52532055C>A	uc010bff.2	-	21	2715	c.2578G>T	c.(2578-2580)GTG>TTG	p.V860L	MYO5C_uc010uga.1_RNA|MYO5C_uc010ugb.1_Intron	NM_018728	NP_061198	Q9NQX4	MYO5C_HUMAN	myosin VC	860	IQ 5.					myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			ovary(7)|central_nervous_system(3)|large_intestine(2)|skin(2)	14				all cancers(107;0.0137)		TGTAGGATCACAGCCTTATGT	0.463		NA											15	23					1.05e-09	1.31e-09	1	0
DENND4A	10260	broad.mit.edu	37	15	66007893	66007893	+	Missense_Mutation	SNP	T	T	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr15:66007893T>A	uc002aph.2	-	14	2254	c.1876A>T	c.(1876-1878)ATT>TTT	p.I626F	DENND4A_uc002api.2_Missense_Mutation_p.I626F|DENND4A_uc002apj.3_Missense_Mutation_p.I626F|DENND4A_uc010ujj.1_Missense_Mutation_p.I626F	NM_005848	NP_005839	Q7Z401	MYCPP_HUMAN	DENN/MADD domain containing 4A isoform 2	626	dDENN.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	4						ATGAAGCGAATAAACATTTGT	0.328		NA											7	21					0	0	0	0
IQCH	64799	broad.mit.edu	37	15	67757467	67757467	+	Silent	SNP	G	G	T			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr15:67757467G>T	uc002aqo.1	+	17	2555	c.2508G>T	c.(2506-2508)GTG>GTT	p.V836V	IQCH_uc002aqq.1_Silent_p.V493V|IQCH_uc002aqp.1_Silent_p.V497V|uc002aqr.1_Intron	NM_001031715	NP_001026885	Q86VS3	IQCH_HUMAN	IQ motif containing H isoform 1	836										skin(3)|ovary(1)	4				Colorectal(3;0.0856)		TTAATCAGGTGTGGGCAACCG	0.517		NA											21	43					9.58e-11	1.22e-10	1	0
TBC1D21	161514	broad.mit.edu	37	15	74178505	74178505	+	Silent	SNP	T	T	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr15:74178505T>A	uc002avz.2	+	7	749	c.666T>A	c.(664-666)GCT>GCA	p.A222A	TBC1D21_uc010ulc.1_Silent_p.A186A	NM_153356	NP_699187	Q8IYX1	TBC21_HUMAN	TBC1 domain family, member 21	222	Rab-GAP TBC.					intracellular	Rab GTPase activator activity	p.A222P(1)		ovary(2)	2						CCGTGTTTGCTGAGCACCTAA	0.592		NA											15	35					0	0	0	0
ACSBG1	23205	broad.mit.edu	37	15	78474423	78474423	+	Missense_Mutation	SNP	T	T	C			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr15:78474423T>C	uc002bdh.2	-	8	1015	c.959A>G	c.(958-960)GAG>GGG	p.E320G	ACSBG1_uc010umw.1_Missense_Mutation_p.E316G|ACSBG1_uc010umx.1_Missense_Mutation_p.E78G|ACSBG1_uc010umy.1_Missense_Mutation_p.E213G	NM_015162	NP_055977	Q96GR2	ACBG1_HUMAN	lipidosin	320					long-chain fatty acid metabolic process|myelination|very long-chain fatty acid metabolic process	cytoplasmic membrane-bounded vesicle|endoplasmic reticulum|microsome	ATP binding|long-chain fatty acid-CoA ligase activity|very long-chain fatty acid-CoA ligase activity			ovary(1)	1						GACTACCACCTCCTGCTGGAC	0.627		NA											21	32					0	0	0	0
IL16	3603	broad.mit.edu	37	15	81517813	81517813	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr15:81517813C>T	uc002bgh.3	+	2	449	c.73C>T	c.(73-75)CTC>TTC	p.L25F	IL16_uc002bgc.2_RNA|IL16_uc010blq.1_Missense_Mutation_p.L25F|IL16_uc002bge.3_RNA|IL16_uc010unp.1_Missense_Mutation_p.L67F|IL16_uc002bgg.2_Missense_Mutation_p.L25F	NM_172217	NP_757366	Q14005	IL16_HUMAN	interleukin 16 isoform 2	25					immune response|interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|extracellular space|nucleus|plasma membrane	cytokine activity			ovary(2)|lung(1)|skin(1)	4						GTCCCTGATGCTCTGTAATGC	0.498		NA											19	50					0	0	0	0
TMC3	342125	broad.mit.edu	37	15	81625263	81625263	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr15:81625263G>T	uc002bgo.1	-	22	2800	c.2800C>A	c.(2800-2802)CGC>AGC	p.R934S	TMC3_uc010blr.1_RNA	NM_001080532	NP_001074001	Q7Z5M5	TMC3_HUMAN	transmembrane channel-like 3	934	Cytoplasmic (Potential).					integral to membrane				ovary(1)|liver(1)	2						GGAGGCTGGCGGGGGACCCGG	0.552		NA											13	44					9.05e-12	1.17e-11	1	0
ADAMTSL3	57188	broad.mit.edu	37	15	84657464	84657464	+	Silent	SNP	G	G	T	rs141705388		TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr15:84657464G>T	uc002bjz.3	+	22	3962	c.3738G>T	c.(3736-3738)GGG>GGT	p.G1246G	ADAMTSL3_uc010bmt.1_Silent_p.G1246G|ADAMTSL3_uc010bmu.1_Silent_p.G1246G	NM_207517	NP_997400	P82987	ATL3_HUMAN	ADAMTS-like 3 precursor	1246	Ig-like C2-type 2.					proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			ovary(6)|central_nervous_system(5)|lung(5)|large_intestine(4)|breast(3)|skin(2)|kidney(1)|pancreas(1)	27			BRCA - Breast invasive adenocarcinoma(143;0.211)			ATGGAACTGGGAAGATACAGA	0.373		NA											8	39					5.18e-06	5.92e-06	1	0
ZNF592	9640	broad.mit.edu	37	15	85326315	85326315	+	Missense_Mutation	SNP	A	A	C			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr15:85326315A>C	uc002bld.2	+	4	745	c.409A>C	c.(409-411)ACC>CCC	p.T137P	ZNF592_uc010upb.1_RNA	NM_014630	NP_055445	Q92610	ZN592_HUMAN	zinc finger protein 592	137					cell death|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(4)|skin(2)	6			BRCA - Breast invasive adenocarcinoma(143;0.0587)			GCCATTACCCACCTTCAACCA	0.478		NA											49	91					0	0	0	0
AGBL1	123624	broad.mit.edu	37	15	86790944	86790944	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr15:86790944G>C	uc002blz.1	+	6	511	c.431G>C	c.(430-432)AGC>ACC	p.S144T		NM_152336	NP_689549	Q96MI9	CBPC4_HUMAN	ATP/GTP binding protein-like 1	144					C-terminal protein deglutamylation|protein side chain deglutamylation|proteolysis	cytosol	metallocarboxypeptidase activity|tubulin binding|zinc ion binding				0						TACGTCACCAGCCTGCTCGGG	0.612		NA											12	11					0	0	0	0
PEX11A	8800	broad.mit.edu	37	15	90227164	90227164	+	Missense_Mutation	SNP	T	T	C			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr15:90227164T>C	uc002boi.2	-	3	283	c.188A>G	c.(187-189)AAT>AGT	p.N63S	PEX11A_uc010upy.1_RNA	NM_003847	NP_003838	O75192	PX11A_HUMAN	peroxisomal biogenesis factor 11 alpha	63	Cytoplasmic (Potential).				cellular lipid metabolic process|peroxisome fission|signal transduction	integral to peroxisomal membrane					0	Lung NSC(78;0.0237)|all_lung(78;0.0478)		KIRC - Kidney renal clear cell carcinoma(17;0.0286)|Kidney(142;0.0514)|BRCA - Breast invasive adenocarcinoma(143;0.128)			ATGTACCACATTGCCTAGTCT	0.448		NA											23	48					0	0	0	0
NR2F2	7026	broad.mit.edu	37	15	96875646	96875646	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr15:96875646G>C	uc010uri.1	+	1	1536	c.312G>C	c.(310-312)AAG>AAC	p.K104N	NR2F2_uc002btp.2_Intron|NR2F2_uc010urj.1_5'Flank|MIR1469_hsa-mir-1469|MI0007074_5'Flank|NR2F2_uc010urk.1_5'Flank	NM_021005	NP_066285	P24468	COT2_HUMAN	nuclear receptor subfamily 2, group F, member 2	104	Nuclear receptor.				lipid metabolic process|negative regulation of cyclin-dependent protein kinase activity|negative regulation of endothelial cell migration|negative regulation of endothelial cell proliferation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|regulation of transcription involved in lymphatic endothelial cell fate commitment	nucleus	ligand-regulated transcription factor activity|protein homodimerization activity|retinoic acid binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|transcription corepressor activity|zinc ion binding			ovary(2)|breast(1)	3	Lung NSC(78;0.0186)|Melanoma(26;0.0195)|all_lung(78;0.0297)		OV - Ovarian serous cystadenocarcinoma(32;0.0856)			GCTTCTTCAAGCGCAGCGTGC	0.612		NA											8	28					0	0	0	0
CREBBP	1387	broad.mit.edu	37	16	3781465	3781465	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr16:3781465C>A	uc002cvv.2	-	30	5104	c.4900G>T	c.(4900-4902)GTG>TTG	p.V1634L	CREBBP_uc002cvw.2_Missense_Mutation_p.V1596L	NM_004380	NP_004371	Q92793	CBP_HUMAN	CREB binding protein isoform a	1634	Interaction with TRERF1.				cellular lipid metabolic process|homeostatic process|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|protein complex assembly|response to hypoxia	cytoplasm|nuclear body	histone acetyltransferase activity|MyoD binding|p53 binding|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription coactivator activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(97)|ovary(14)|lung(6)|skin(6)|breast(2)|NS(1)|pancreas(1)	127		Ovarian(90;0.0266)		OV - Ovarian serous cystadenocarcinoma(1;3.54e-05)		AGGTGGATCACGAAGAAGACC	0.642		NA	T|N|F|Mis|O	MLL|MORF|RUNXBP2	ALL|AML|DLBCL|B-NHL 		Rubinstein-Taybi syndrome		Rubinstein-Taybi_syndrome				6	1					0.00198382	0.00211565	1	0
A2BP1	54715	broad.mit.edu	37	16	7629790	7629790	+	Silent	SNP	C	C	T	rs145861898	byFrequency	TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr16:7629790C>T	uc002cys.2	+	6	1270	c.282C>T	c.(280-282)GAC>GAT	p.D94D	A2BP1_uc010buf.1_Silent_p.D94D|A2BP1_uc002cyr.1_Silent_p.D93D|A2BP1_uc002cyt.2_Silent_p.D94D|A2BP1_uc010uxz.1_Silent_p.D137D|A2BP1_uc010uya.1_Intron|A2BP1_uc002cyv.1_Silent_p.D94D|A2BP1_uc010uyb.1_Silent_p.D94D|A2BP1_uc002cyw.2_Silent_p.D114D|A2BP1_uc002cyy.2_Silent_p.D114D|A2BP1_uc002cyx.2_Silent_p.D114D|A2BP1_uc010uyc.1_Silent_p.D114D	NM_018723	NP_061193	Q9NWB1	RFOX1_HUMAN	ataxin 2-binding protein 1 isoform 4	94					mRNA processing|RNA splicing|RNA transport	nucleus|trans-Golgi network	nucleotide binding|protein C-terminus binding|RNA binding				0		all_cancers(2;4.54e-52)|Colorectal(2;6.95e-44)|all_epithelial(2;1.15e-37)|Lung NSC(2;0.000289)|all_lung(2;0.00148)|Myeloproliferative disorder(2;0.0122)|Medulloblastoma(2;0.0354)|all_neural(2;0.0381)|all_hematologic(2;0.0749)|Renal(2;0.0758)|Melanoma(2;0.211)		Colorectal(1;3.55e-51)|COAD - Colon adenocarcinoma(2;1.92e-46)|all cancers(1;5.36e-16)|Epithelial(1;3.98e-15)|READ - Rectum adenocarcinoma(2;3.71e-05)|GBM - Glioblastoma multiforme(1;0.0499)		AGACAGATGACGCAGCACCGA	0.517		NA											40	56					0	0	0	0
C16orf68	79091	broad.mit.edu	37	16	8736032	8736032	+	Missense_Mutation	SNP	A	A	G			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr16:8736032A>G	uc002cyz.2	+	8	1151	c.875A>G	c.(874-876)TAC>TGC	p.Y292C	C16orf68_uc002cza.2_Missense_Mutation_p.Y236C	NM_024109	NP_077014	Q9BUU2	MET22_HUMAN	hypothetical protein LOC79091	292							methyltransferase activity				0						TCTGACTTGTACGATCACACC	0.478		NA											16	59					0	0	0	0
CLN3	1201	broad.mit.edu	37	16	28493805	28493805	+	Missense_Mutation	SNP	T	T	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr16:28493805T>A	uc002dpo.2	-	11	1222	c.899A>T	c.(898-900)CAG>CTG	p.Q300L	uc010vct.1_Intron|CLN3_uc002dpl.2_Missense_Mutation_p.Q222L|CLN3_uc010vcu.1_Missense_Mutation_p.Q200L|CLN3_uc002dpn.2_Missense_Mutation_p.Q201L|CLN3_uc002dpm.2_Missense_Mutation_p.Q246L|CLN3_uc010vcv.1_Missense_Mutation_p.Q276L|CLN3_uc010byd.2_Missense_Mutation_p.Q300L|CLN3_uc002dpp.2_Missense_Mutation_p.Q300L|CLN3_uc002dpt.1_Missense_Mutation_p.Q200L|CLN3_uc002dpq.1_Missense_Mutation_p.Q252L|CLN3_uc010bye.1_Intron|CLN3_uc002dpr.1_RNA|CLN3_uc010byf.1_RNA|CLN3_uc002dps.1_Missense_Mutation_p.Q173L|CLN3_uc002dpu.1_Missense_Mutation_p.Q198L|CLN3_uc002dpw.1_Missense_Mutation_p.Q147L|CLN3_uc010vcw.1_Missense_Mutation_p.Q246L|CLN3_uc002dqa.2_3'UTR|CLN3_uc010vcx.1_3'UTR|CLN3_uc002dpx.1_Missense_Mutation_p.Q177L|CLN3_uc002dpy.1_Missense_Mutation_p.Q144L	NM_000086	NP_000077	Q13286	CLN3_HUMAN	ceroid-lipofuscinosis, neuronal 3	300					amyloid precursor protein catabolic process|arginine transport|associative learning|autophagic vacuole fusion|cell death|cellular amino acid metabolic process|cytosolic calcium ion homeostasis|galactosylceramide metabolic process|globoside metabolic process|glucosylceramide metabolic process|ionotropic glutamate receptor signaling pathway|lysosomal lumen acidification|lysosomal lumen pH elevation|negative regulation of catalytic activity|negative regulation of macroautophagy|negative regulation of neuron apoptosis|negative regulation of proteolysis|neuromuscular process controlling balance|neurotransmitter metabolic process|protein catabolic process|protein folding|protein processing|receptor-mediated endocytosis|regulation of action potential|sphingomyelin metabolic process|vacuolar transport	autophagic vacuole|caveola|cytosol|early endosome|Golgi membrane|Golgi stack|integral to endoplasmic reticulum membrane|late endosome|lysosomal membrane|membrane fraction|mitochondrion|neuron projection|nucleus|synaptic vesicle|trans-Golgi network	unfolded protein binding				0						TACAAGTCCCTGGTTAATGAA	0.547		NA											22	38					0	0	0	0
SEPHS2	22928	broad.mit.edu	37	16	30456594	30456594	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr16:30456594C>A	uc010ves.1	-	2	631	c.455G>T	c.(454-456)CGC>CTC	p.R152L	SEPHS2_uc002dyh.1_Missense_Mutation_p.R95L|SEPHS2_uc010vet.1_Missense_Mutation_p.R34L	NM_012248	NP_036380	Q99611	SPS2_HUMAN	selenophosphate synthetase 2	152					selenocysteine biosynthetic process		ATP binding|selenide, water dikinase activity			breast(2)	2						ACAAGCTATGCGCCCCATCAT	0.547		NA											23	46					5.35e-06	6.11e-06	1	0
ITFG1	81533	broad.mit.edu	37	16	47345160	47345160	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr16:47345160G>A	uc002eet.2	-	10	1123	c.1061C>T	c.(1060-1062)ACA>ATA	p.T354I	ITFG1_uc010vgg.1_Missense_Mutation_p.T99I|ITFG1_uc010vgh.1_Missense_Mutation_p.T241I	NM_030790	NP_110417	Q8TB96	TIP_HUMAN	integrin alpha FG-GAP repeat containing 1	354						extracellular region|integral to membrane				ovary(1)|central_nervous_system(1)	2		all_cancers(37;0.0613)|all_lung(18;0.0543)|Lung NSC(13;0.227)				CCTTCCAGATGTGTTCTTTAG	0.353		NA											15	25					0	0	0	0
CNGB1	1258	broad.mit.edu	37	16	57931410	57931410	+	Missense_Mutation	SNP	T	T	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr16:57931410T>A	uc002emt.2	-	31	3198	c.3133A>T	c.(3133-3135)AAC>TAC	p.N1045Y	CNGB1_uc010cdh.2_Missense_Mutation_p.N1039Y	NM_001297	NP_001288	Q14028	CNGB1_HUMAN	cyclic nucleotide gated channel beta 1 isoform	1045	Cytoplasmic (Potential).|cAMP (By similarity).				sensory perception of smell	intracellular cyclic nucleotide activated cation channel complex	cAMP binding|intracellular cAMP activated cation channel activity			breast(3)|pancreas(1)	4						GCCACCACGTTGGCCGTGCGC	0.557		NA											14	33					0	0	0	0
CDH8	1006	broad.mit.edu	37	16	61935119	61935119	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr16:61935119G>T	uc002eog.1	-	3	763	c.511C>A	c.(511-513)CCC>ACC	p.P171T		NM_001796	NP_001787	P55286	CADH8_HUMAN	cadherin 8, type 2 preproprotein	171	Extracellular (Potential).|Cadherin 2.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(6)|skin(2)|breast(1)	9		Ovarian(137;0.0799)|Melanoma(118;0.16)		UCEC - Uterine corpus endometrioid carcinoma (183;0.196)|Epithelial(162;0.0155)|all cancers(182;0.0305)|OV - Ovarian serous cystadenocarcinoma(108;0.0499)|BRCA - Breast invasive adenocarcinoma(181;0.249)		GCATGATAGGGTCCATTAAGA	0.398		NA											30	59					4.03e-09	4.96e-09	1	0
CDH11	1009	broad.mit.edu	37	16	64984725	64984725	+	Silent	SNP	G	G	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr16:64984725G>A	uc002eoi.2	-	12	2273	c.1839C>T	c.(1837-1839)GCC>GCT	p.A613A	CDH11_uc010cdn.2_RNA|CDH11_uc002eoj.2_Silent_p.A613A|CDH11_uc010vin.1_Silent_p.A487A	NM_001797	NP_001788	P55287	CAD11_HUMAN	cadherin 11, type 2 preproprotein	613	Extracellular (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion|ossification|skeletal system development	integral to membrane|plasma membrane	calcium ion binding|protein binding			lung(10)|ovary(3)|skin(1)	14		Ovarian(137;0.0973)		OV - Ovarian serous cystadenocarcinoma(108;0.205)		TGCTCAGGCCGGCGTTCAGAA	0.637		NA	T	USP6	aneurysmal bone cysts					TSP Lung(24;0.17)			13	25					0	0	0	0
CDH11	1009	broad.mit.edu	37	16	65022110	65022110	+	Nonsense_Mutation	SNP	C	C	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr16:65022110C>A	uc002eoi.2	-	7	1383	c.949G>T	c.(949-951)GAA>TAA	p.E317*	CDH11_uc010cdn.2_Intron|CDH11_uc002eoj.2_Nonsense_Mutation_p.E317*|CDH11_uc010vin.1_Nonsense_Mutation_p.E191*	NM_001797	NP_001788	P55287	CAD11_HUMAN	cadherin 11, type 2 preproprotein	317	Cadherin 3.|Extracellular (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion|ossification|skeletal system development	integral to membrane|plasma membrane	calcium ion binding|protein binding			lung(10)|ovary(3)|skin(1)	14		Ovarian(137;0.0973)		OV - Ovarian serous cystadenocarcinoma(108;0.205)		GTTGTGATTTCAAACGATTCC	0.443		NA	T	USP6	aneurysmal bone cysts					TSP Lung(24;0.17)			71	106					9.43e-34	1.37e-33	1	0
SLC12A4	6560	broad.mit.edu	37	16	67981323	67981323	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr16:67981323C>T	uc002euz.2	-	16	2124	c.1983G>A	c.(1981-1983)TGG>TGA	p.W661*	SLC12A4_uc010ceu.2_Nonsense_Mutation_p.W655*|SLC12A4_uc010vkh.1_Nonsense_Mutation_p.W630*|SLC12A4_uc010vki.1_Nonsense_Mutation_p.W661*|SLC12A4_uc010vkj.1_Nonsense_Mutation_p.W663*|SLC12A4_uc002eva.2_Nonsense_Mutation_p.W661*|SLC12A4_uc010cev.1_RNA|SLC12A4_uc002evb.2_RNA	NM_005072	NP_005063	Q9UP95	S12A4_HUMAN	solute carrier family 12, member 4 isoform a	661					cell volume homeostasis|potassium ion transport|sodium ion transport	integral to plasma membrane|membrane fraction	potassium:chloride symporter activity			ovary(1)	1		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0042)|Epithelial(162;0.0185)|all cancers(182;0.121)	Bumetanide(DB00887)|Potassium Chloride(DB00761)	TCCCGTCACCCCACTCCTTCT	0.667		NA											5	10					0	0	0	0
NFAT5	10725	broad.mit.edu	37	16	69727108	69727108	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr16:69727108C>G	uc002exm.1	+	12	4534	c.3326C>G	c.(3325-3327)TCT>TGT	p.S1109C	NFAT5_uc002exi.2_Missense_Mutation_p.S1033C|NFAT5_uc002exj.1_Missense_Mutation_p.S1033C|NFAT5_uc002exk.1_Missense_Mutation_p.S1033C|NFAT5_uc002exl.1_Missense_Mutation_p.S1127C|NFAT5_uc002exn.1_Missense_Mutation_p.S1126C|NFAT5_uc002exo.1_RNA	NM_006599	NP_006590	O94916	NFAT5_HUMAN	nuclear factor of activated T-cells 5 isoform c	1109					excretion|signal transduction|transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity				0						ACAACCTCCTCTGAACAAATG	0.438		NA											35	122					0	0	0	0
ZFHX3	463	broad.mit.edu	37	16	72821667	72821667	+	Missense_Mutation	SNP	T	T	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr16:72821667T>A	uc002fck.2	-	10	11181	c.10508A>T	c.(10507-10509)CAC>CTC	p.H3503L	uc002fcj.1_RNA|ZFHX3_uc002fcl.2_Missense_Mutation_p.H2589L	NM_006885	NP_008816	Q15911	ZFHX3_HUMAN	zinc finger homeobox 3 isoform A	3503					muscle organ development|negative regulation of myoblast differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|positive regulation of myoblast differentiation	transcription factor complex	enzyme binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(2)|skin(2)	4		Ovarian(137;0.13)				gGTGGGGACGTGAAGCACCAT	0.433		NA											13	29					0	0	0	0
ANKRD11	29123	broad.mit.edu	37	16	89351869	89351869	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr16:89351869C>A	uc002fmx.1	-	9	1542	c.1081G>T	c.(1081-1083)GTG>TTG	p.V361L	ANKRD11_uc002fmy.1_Missense_Mutation_p.V361L|ANKRD11_uc002fnc.1_Missense_Mutation_p.V361L|ANKRD11_uc002fnb.1_Missense_Mutation_p.V318L	NM_013275	NP_037407	Q6UB99	ANR11_HUMAN	ankyrin repeat domain 11	361						nucleus				ovary(4)|large_intestine(1)|central_nervous_system(1)	6		all_hematologic(23;0.00824)|Colorectal(91;0.0475)		Epithelial(1;5.33e-11)|all cancers(4;2.6e-09)|OV - Ovarian serous cystadenocarcinoma(4;2.29e-07)|BRCA - Breast invasive adenocarcinoma(80;0.0142)		TTGTCGTCCACCGGAGGAACC	0.468		NA											60	125					1.93e-42	2.82e-42	1	0
PRPF8	10594	broad.mit.edu	37	17	1576801	1576801	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr17:1576801C>A	uc002fte.2	-	23	3621	c.3507G>T	c.(3505-3507)CAG>CAT	p.Q1169H		NM_006445	NP_006436	Q6P2Q9	PRP8_HUMAN	U5 snRNP-specific protein	1169						catalytic step 2 spliceosome|nuclear speck|U5 snRNP	protein binding|RNA binding			lung(4)|ovary(2)	6				UCEC - Uterine corpus endometrioid carcinoma (25;0.0855)		TGTTCTCCCACTGAACTGTAG	0.547		NA											29	57					2.44e-19	3.37e-19	1	0
OR3A1	4994	broad.mit.edu	37	17	3195410	3195410	+	Missense_Mutation	SNP	A	A	G			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr17:3195410A>G	uc002fvh.1	-	1	467	c.467T>C	c.(466-468)TTC>TCC	p.F156S		NM_002550	NP_002541	P47881	OR3A1_HUMAN	olfactory receptor, family 3, subfamily A,	156	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			kidney(2)|central_nervous_system(1)	3						TGCGTTGGTGAAAGCACAAGC	0.572		NA											47	102					0	0	0	0
ALOX12	239	broad.mit.edu	37	17	6913397	6913397	+	Silent	SNP	T	T	C			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr17:6913397T>C	uc002gdx.3	+	13	1817	c.1764T>C	c.(1762-1764)TGT>TGC	p.C588C	uc002gdy.1_Intron|ALOX12_uc002gdz.3_Silent_p.C58C|RNASEK_uc002gea.2_5'Flank|C17orf49_uc002geb.3_5'Flank|C17orf49_uc002gec.2_5'Flank	NM_000697	NP_000688	P18054	LOX12_HUMAN	arachidonate 12-lipoxygenase	588	Lipoxygenase.				anti-apoptosis|cellular component movement|fatty acid oxidation|leukotriene biosynthetic process|positive regulation of cell adhesion|positive regulation of cell growth|positive regulation of cell proliferation|superoxide anion generation	cytosol|sarcolemma	arachidonate 12-lipoxygenase activity|hepoxilin-epoxide hydrolase activity|iron ion binding|lipoxygenase activity|protein binding			central_nervous_system(1)	1						GGCAGGCCTGTCTTCAAATGG	0.562		NA											13	34					0	0	0	0
NLGN2	57555	broad.mit.edu	37	17	7317751	7317751	+	Silent	SNP	A	A	T			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr17:7317751A>T	uc002ggt.1	+	3	670	c.597A>T	c.(595-597)TCA>TCT	p.S199S		NM_020795	NP_065846	Q8NFZ4	NLGN2_HUMAN	neuroligin 2 precursor	199	Extracellular (Potential).				cell-cell junction maintenance|neuron cell-cell adhesion|positive regulation of synaptogenesis|regulation of inhibitory postsynaptic membrane potential|synapse assembly	cell surface|integral to plasma membrane|postsynaptic membrane	neurexin binding|receptor activity			central_nervous_system(1)	1		Prostate(122;0.157)				TCGATGGCTCAGTCCTGGCTG	0.597		NA											27	73					0	0	0	0
TP53	7157	broad.mit.edu	37	17	7577568	7577568	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr17:7577568C>A	uc002gim.2	-	7	907	c.713G>T	c.(712-714)TGT>TTT	p.C238F	TP53_uc002gig.1_Missense_Mutation_p.C238F|TP53_uc002gih.2_Missense_Mutation_p.C238F|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.C106F|TP53_uc010cng.1_Missense_Mutation_p.C106F|TP53_uc002gii.1_Missense_Mutation_p.C106F|TP53_uc010cnh.1_Missense_Mutation_p.C238F|TP53_uc010cni.1_Missense_Mutation_p.C238F|TP53_uc002gij.2_Missense_Mutation_p.C238F|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.C145F|TP53_uc002gio.2_Missense_Mutation_p.C106F	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	238	|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).	Zinc.	C -> G (in LFS; germline mutation and in sporadic cancers; somatic mutation).|C -> F (in sporadic cancers; somatic mutation).|C -> S (in LFS; germline mutation and in sporadic cancers; somatic mutation).|C -> W (in sporadic cancers; somatic mutation).|C -> H (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|C -> Y (in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation).|C -> R (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.C238Y(47)|p.C238F(34)|p.C238S(18)|p.C238R(14)|p.0?(7)|p.C238*(4)|p.C238W(2)|p.Y236_M243delYMCNSSCM(1)|p.C238fs*2(1)|p.V225fs*23(1)|p.C238_N239insX(1)|p.C238_M246delCNSSCMGGM(1)|p.C238fs*9(1)|p.M237_N239delMCN(1)|p.C238fs*21(1)|p.C238del(1)|p.C238G(1)|p.C238C(1)|p.M237fs*1(1)|p.C145F(1)|p.H233fs*6(1)|p.H233_C242del10(1)|p.N239_C242del(1)|p.M237_C238insX(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GGAACTGTTACACATGTAGTT	0.572		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			20	62					1.26e-06	1.47e-06	1	0
TP53	7157	broad.mit.edu	37	17	7578463	7578463	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr17:7578463C>G	uc002gim.2	-	5	661	c.467G>C	c.(466-468)CGC>CCC	p.R156P	TP53_uc002gig.1_Missense_Mutation_p.R156P|TP53_uc002gih.2_Missense_Mutation_p.R156P|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.R24P|TP53_uc010cng.1_Missense_Mutation_p.R24P|TP53_uc002gii.1_Missense_Mutation_p.R24P|TP53_uc010cnh.1_Missense_Mutation_p.R156P|TP53_uc010cni.1_Missense_Mutation_p.R156P|TP53_uc002gij.2_Missense_Mutation_p.R156P|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.R63P|TP53_uc002gio.2_Missense_Mutation_p.R24P|TP53_uc010vug.1_Missense_Mutation_p.R117P	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	156	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		R -> P (in sporadic cancers; somatic mutation).|R -> G (in sporadic cancers; somatic mutation).|R -> H (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> L (in sporadic cancers; somatic mutation).|R -> C (in sporadic cancers; somatic mutation).|R -> S (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R156P(24)|p.R156H(10)|p.R156fs*14(8)|p.0?(7)|p.R156S(3)|p.R156R(3)|p.R156fs*25(3)|p.R156G(3)|p.R156L(3)|p.R156_I162delRVRAMAI(2)|p.T155fs*23(2)|p.P153fs*22(2)|p.R156C(2)|p.T155_R156delTR(1)|p.R156_A161delRVRAMA(1)|p.P151_V173del23(1)|p.R156del(1)|p.R156_R158delRVR(1)|p.R156fs*12(1)|p.R156fs*18(1)|p.R156_A161del(1)|p.D148fs*23(1)|p.S149fs*72(1)|p.T155_A161delTRVRAMA(1)|p.G154fs*22(1)|p.G154_R156delGTR(1)|p.R156fs*20(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GGCGCGGACGCGGGTGCCGGG	0.612		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			17	43					0	0	0	0
DNAH2	146754	broad.mit.edu	37	17	7734089	7734089	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr17:7734089G>T	uc002giu.1	+	78	12173	c.12159G>T	c.(12157-12159)TGG>TGT	p.W4053C	DNAH2_uc010cnm.1_Missense_Mutation_p.W991C	NM_020877	NP_065928	Q9P225	DYH2_HUMAN	dynein heavy chain domain 3	4053					ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(6)|skin(6)|central_nervous_system(1)	13		all_cancers(10;4.66e-07)|Prostate(122;0.081)				CAGATGACTGGGACCGGCGCC	0.547		NA											18	43					3.41e-10	4.28e-10	1	0
ARHGEF15	22899	broad.mit.edu	37	17	8219105	8219105	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr17:8219105C>A	uc002glc.2	+	8	1575	c.1454C>A	c.(1453-1455)TCT>TAT	p.S485Y	ARHGEF15_uc002gld.2_Missense_Mutation_p.S485Y|ARHGEF15_uc010vuw.1_Missense_Mutation_p.S374Y	NM_173728	NP_776089	O94989	ARHGF_HUMAN	Rho guanine exchange factor 15	485	DH.				negative regulation of synapse maturation|regulation of Rho protein signal transduction	dendrite|intracellular	GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			ovary(2)|skin(1)	3						CGTGTGCGCTCTTCCCCCCAC	0.577		NA											17	18					5.35e-07	6.29e-07	1	0
PIK3R6	146850	broad.mit.edu	37	17	8707437	8707437	+	Missense_Mutation	SNP	T	T	C			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr17:8707437T>C	uc002glq.1	-	20	2270	c.2030A>G	c.(2029-2031)CAG>CGG	p.Q677R	PIK3R6_uc002glr.1_RNA|PIK3R6_uc002gls.1_RNA	NM_001010855	NP_001010855	Q5UE93	PI3R6_HUMAN	phosphoinositide-3-kinase, regulatory subunit 6	677					platelet activation	cytosol					0						GCTCTGGATCTGGATATTGTT	0.587		NA											12	20					0	0	0	0
GAS7	8522	broad.mit.edu	37	17	10101583	10101583	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr17:10101583C>A	uc002gmg.1	-	1	286	c.125G>T	c.(124-126)GGC>GTC	p.G42V		NM_201433	NP_958839	O60861	GAS7_HUMAN	growth arrest-specific 7 isoform c	42	SH3.				cell cycle arrest	cytoplasm	sequence-specific DNA binding transcription factor activity			lung(1)|pancreas(1)	2						CTCCTTCTCGCCTTCCCACCA	0.726		NA	T	MLL	AML*								17	31					8.34e-07	9.73e-07	1	0
DNAH9	1770	broad.mit.edu	37	17	11757566	11757566	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr17:11757566C>A	uc002gne.2	+	50	9822	c.9754C>A	c.(9754-9756)CCT>ACT	p.P3252T	DNAH9_uc010coo.2_Missense_Mutation_p.P2546T	NM_001372	NP_001363	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9 isoform 2	3252	Stalk (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			skin(10)|ovary(4)|breast(3)|central_nervous_system(2)|pancreas(1)	20		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		CGAGTTCAATCCTGAGTTTGT	0.488		NA											40	106					1.7e-12	2.22e-12	1	0
UBB	7314	broad.mit.edu	37	17	16285753	16285753	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr17:16285753G>A	uc002gpx.2	+	2	670	c.532G>A	c.(532-534)GTG>ATG	p.V178M	UBB_uc010vwe.1_Missense_Mutation_p.V102M	NM_018955	NP_061828	P0CG47	UBB_HUMAN	ubiquitin B precursor	178	Ubiquitin-like 3.				activation of MAPK activity|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|anti-apoptosis|apoptosis|cellular membrane organization|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA repair|endosome transport|epidermal growth factor receptor signaling pathway|G1/S transition of mitotic cell cycle|I-kappaB kinase/NF-kappaB cascade|induction of apoptosis by extracellular signals|innate immune response|JNK cascade|M/G1 transition of mitotic cell cycle|mRNA metabolic process|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of type I interferon production|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|S phase of mitotic cell cycle|stress-activated MAPK cascade|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|viral reproduction	cytosol|endocytic vesicle membrane|endosome membrane|nucleoplasm|plasma membrane	protein binding			skin(3)	3				UCEC - Uterine corpus endometrioid carcinoma (92;0.0822)		CATCGAAAATGTGAAGGCCAA	0.552		NA											21	47					0	0	0	0
TRIM16L	147166	broad.mit.edu	37	17	18638707	18638707	+	Silent	SNP	C	C	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr17:18638707C>A	uc002gug.1	+	10	1668	c.981C>A	c.(979-981)ATC>ATA	p.I327I	TRIM16L_uc010vyf.1_Silent_p.I381I|TRIM16L_uc002guh.1_Silent_p.I327I|TRIM16L_uc010cqg.1_Silent_p.I429I|TRIM16L_uc002gui.1_Silent_p.I327I|TRIM16L_uc010vyg.1_Silent_p.I327I|TRIM16L_uc010vyh.1_3'UTR	NM_001037330	NP_001032407	Q309B1	TR16L_HUMAN	tripartite motif-containing 16-like	327	B30.2/SPRY.					cytoplasm					0						AAAACGCCATCCGGATTGTAG	0.527		NA											8	33					3.53e-06	4.06e-06	1	0
ACCN1	40	broad.mit.edu	37	17	32483062	32483062	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr17:32483062G>T	uc002hhu.2	-	1	764	c.490C>A	c.(490-492)CTG>ATG	p.L164M		NM_001094	NP_001085	Q16515	ACCN1_HUMAN	amiloride-sensitive cation channel 1, neuronal	164	Extracellular (By similarity).				central nervous system development|peripheral nervous system development|synaptic transmission	integral to plasma membrane	ligand-gated sodium channel activity|protein binding			ovary(2)|large_intestine(1)|central_nervous_system(1)	4		Breast(31;0.042)|Ovarian(249;0.202)		UCEC - Uterine corpus endometrioid carcinoma (308;0.13)|BRCA - Breast invasive adenocarcinoma(366;0.215)	Amiloride(DB00594)	ATATCCTTCAGGTCATGGCCC	0.557		NA											23	72					1.18e-14	1.58e-14	1	0
GAS2L2	246176	broad.mit.edu	37	17	34074283	34074283	+	Silent	SNP	G	G	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr17:34074283G>A	uc002hjv.1	-	5	865	c.837C>T	c.(835-837)CAC>CAT	p.H279H		NM_139285	NP_644814	Q8NHY3	GA2L2_HUMAN	growth arrest-specific 2 like 2	279					cell cycle arrest	cytoplasm|cytoskeleton				ovary(1)|skin(1)	2		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		TGCCTGGCTTGTGTGCTACCA	0.597		NA											52	101					0	0	0	0
TADA2A	6871	broad.mit.edu	37	17	35818669	35818669	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr17:35818669G>T	uc002hnt.2	+	9	805	c.648G>T	c.(646-648)AAG>AAT	p.K216N	TADA2A_uc002hnu.1_Missense_Mutation_p.K216N|TADA2A_uc002hnv.2_Missense_Mutation_p.K216N|TADA2A_uc010wdd.1_Missense_Mutation_p.K216N|TADA2A_uc002hnw.2_Missense_Mutation_p.K115N|TADA2A_uc010cvb.2_Missense_Mutation_p.K12N	NM_001488	NP_001479	O75478	TAD2A_HUMAN	transcriptional adaptor 2A isoform a	216					histone H3 acetylation|transcription from RNA polymerase II promoter	chromosome|PCAF complex	DNA binding|sequence-specific DNA binding transcription factor activity|transcription cofactor activity|zinc ion binding			breast(3)|skin(1)	4						CCAGGTTAAAGGAGAGACAAA	0.229		NA											13	34					2.32e-09	2.87e-09	1	0
ORMDL3	94103	broad.mit.edu	37	17	38079494	38079494	+	Missense_Mutation	SNP	G	G	A	rs139204234	byFrequency	TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr17:38079494G>A	uc002htj.1	-	3	337	c.197C>T	c.(196-198)ACG>ATG	p.T66M	ORMDL3_uc002hti.1_RNA|ORMDL3_uc002htk.1_Missense_Mutation_p.T66M	NM_139280	NP_644809	Q8N138	ORML3_HUMAN	ORM1-like 3	66	Lumenal (Potential).				ceramide metabolic process	integral to membrane|SPOTS complex	protein binding				0	Colorectal(19;0.000442)		Lung(15;0.0234)			CCCCTTCACCGTGTGCAGGAA	0.582		NA											39	120					0	0	0	0
STAT5B	6777	broad.mit.edu	37	17	40362219	40362219	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr17:40362219C>A	uc002hzh.2	-	15	2045	c.1876G>T	c.(1876-1878)GGC>TGC	p.G626C		NM_012448	NP_036580	P51692	STA5B_HUMAN	signal transducer and activator of transcription	626	SH2.				2-oxoglutarate metabolic process|allantoin metabolic process|citrate metabolic process|creatine metabolic process|creatinine metabolic process|fatty acid metabolic process|isoleucine metabolic process|JAK-STAT cascade involved in growth hormone signaling pathway|oxaloacetate metabolic process|response to estradiol stimulus|succinate metabolic process|taurine metabolic process|valine metabolic process	cytosol|nucleoplasm	calcium ion binding|glucocorticoid receptor binding|sequence-specific DNA binding transcription factor activity			ovary(3)|lung(2)|skin(1)	6		all_cancers(22;4.15e-07)|all_epithelial(22;2.83e-05)|Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.135)	Dasatinib(DB01254)	ATGGTGATGCCGCCAATTTCT	0.428		NA											30	51					2.13e-12	2.77e-12	1	0
PLEKHH3	79990	broad.mit.edu	37	17	40822701	40822701	+	Missense_Mutation	SNP	A	A	T			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr17:40822701A>T	uc002iau.2	-	10	1911	c.1444T>A	c.(1444-1446)TTG>ATG	p.L482M	PLEKHH3_uc010cyl.1_RNA|PLEKHH3_uc002iat.1_RNA|PLEKHH3_uc002iav.2_RNA|PLEKHH3_uc010cym.1_Intron|PLEKHH3_uc002iaw.2_Missense_Mutation_p.L479M	NM_024927	NP_079203	Q7Z736	PKHH3_HUMAN	pleckstrin homology domain containing, family H	482	FERM.				signal transduction	cytoskeleton				large_intestine(1)|ovary(1)	2		Breast(137;0.00116)		BRCA - Breast invasive adenocarcinoma(366;0.14)		GAGTCCTCCAACCCAGCTTCC	0.672		NA											17	19					0	0	0	0
ARL4D	379	broad.mit.edu	37	17	41477216	41477216	+	Missense_Mutation	SNP	A	A	T			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr17:41477216A>T	uc002idt.2	+	2	297	c.116A>T	c.(115-117)TAC>TTC	p.Y39F		NM_001661	NP_001652	P49703	ARL4D_HUMAN	ADP-ribosylation factor-like 4D	39					protein secretion|small GTPase mediated signal transduction	cytoplasm|nucleolus|plasma membrane	GTP binding|GTPase activity|protein binding			ovary(1)	1		Breast(137;0.00908)		BRCA - Breast invasive adenocarcinoma(366;0.155)		TCCCTCCTTTACCGCCTCAAG	0.592		NA											20	40					0	0	0	0
GPATCH8	23131	broad.mit.edu	37	17	42475961	42475961	+	Nonsense_Mutation	SNP	C	C	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr17:42475961C>A	uc002igw.1	-	8	3548	c.3484G>T	c.(3484-3486)GAA>TAA	p.E1162*	GPATCH8_uc002igv.1_Nonsense_Mutation_p.E1084*|GPATCH8_uc010wiz.1_Nonsense_Mutation_p.E1084*	NM_001002909	NP_001002909	Q9UKJ3	GPTC8_HUMAN	G patch domain containing 8	1162						intracellular	nucleic acid binding|zinc ion binding			ovary(2)|kidney(1)|skin(1)	4		Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.206)		CCAGACTCTTCACACTTCTTA	0.542		NA											50	121					1.33e-27	1.91e-27	1	0
ADAM11	4185	broad.mit.edu	37	17	42852065	42852065	+	Splice_Site	SNP	G	G	T			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr17:42852065G>T	uc002ihh.2	+	14	1169	c.1169_splice	c.e14-1	p.G390_splice	ADAM11_uc010wjd.1_Splice_Site_p.G190_splice|ADAM11_uc002ihi.2_5'Flank	NM_002390	NP_002381	O75078	ADA11_HUMAN	ADAM metallopeptidase domain 11 preproprotein						integrin-mediated signaling pathway|proteolysis	integral to membrane|plasma membrane	integrin binding|metalloendopeptidase activity|zinc ion binding			pancreas(1)	1		Prostate(33;0.0959)				TCACCCCTCAGGGGACTGCAA	0.652		NA											11	47					6.4e-05	7.08e-05	1	0
MAPT	4137	broad.mit.edu	37	17	44068882	44068882	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr17:44068882G>C	uc002ijr.3	+	9	1757	c.1437G>C	c.(1435-1437)CAG>CAC	p.Q479H	MAPT_uc010dau.2_Missense_Mutation_p.Q479H|MAPT_uc002ijs.3_Missense_Mutation_p.Q162H|MAPT_uc002ijx.3_Missense_Mutation_p.Q133H|MAPT_uc002ijt.3_Missense_Mutation_p.Q104H|MAPT_uc002iju.3_Missense_Mutation_p.Q104H|MAPT_uc002ijv.3_Missense_Mutation_p.Q111H	NM_016835	NP_058519	P10636	TAU_HUMAN	microtubule-associated protein tau isoform 1	479					cellular component disassembly involved in apoptosis|microtubule cytoskeleton organization|negative regulation of microtubule depolymerization|positive regulation of axon extension|positive regulation of microtubule polymerization|regulation of autophagy	axon|cytosol|growth cone|microtubule|microtubule associated complex|nuclear periphery|plasma membrane|tubulin complex	apolipoprotein E binding|enzyme binding|identical protein binding|lipoprotein particle binding|microtubule binding|protein binding|SH3 domain binding|structural constituent of cytoskeleton			pancreas(1)	1		Melanoma(429;0.216)				CTCCAGGCCAGAAGGGCCAGG	0.542		NA											37	94					0	0	0	0
DLX4	1748	broad.mit.edu	37	17	48050507	48050507	+	Silent	SNP	C	C	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr17:48050507C>A	uc002ipv.2	+	2	625	c.354C>A	c.(352-354)CGC>CGA	p.R118R	DLX4_uc002ipw.2_Silent_p.R46R	NM_138281	NP_612138	Q92988	DLX4_HUMAN	distal-less homeobox 4 isoform a	118	Homeobox.				multicellular organismal development	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						AAAAGCTCCGCAAGCCGAGGA	0.677		NA											4	24					1.58e-08	1.93e-08	1	0
OR4D2	124538	broad.mit.edu	37	17	56247544	56247544	+	Silent	SNP	C	C	T			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr17:56247544C>T	uc010wnp.1	+	1	528	c.528C>T	c.(526-528)AAC>AAT	p.N176N		NM_001004707	NP_001004707	P58180	OR4D2_HUMAN	olfactory receptor, family 4, subfamily D,	176	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|breast(1)	2						TTTTGGATAACTTCTACTGTG	0.547		NA											48	99					0	0	0	0
C17orf82	388407	broad.mit.edu	37	17	59489603	59489603	+	Silent	SNP	C	C	T			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr17:59489603C>T	uc002izh.1	+	1	492	c.267C>T	c.(265-267)CCC>CCT	p.P89P		NM_203425	NP_982249	Q86X59	CQ082_HUMAN	hypothetical protein LOC388407	89											0						GGCACCCTCCCGGGAGCGCCT	0.721		NA									OREG0024630	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	7	7					0	0	0	0
CSH1	1442	broad.mit.edu	37	17	61972895	61972895	+	Missense_Mutation	SNP	A	A	T			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr17:61972895A>T	uc002jcs.1	-	4	510	c.394T>A	c.(394-396)TCG>ACG	p.S132T	CSH2_uc002jck.2_Intron|CSH1_uc002jcp.1_Missense_Mutation_p.S93T|CSH1_uc002jcq.1_Missense_Mutation_p.S93T|CSH1_uc002jcr.1_3'UTR|CSH1_uc002jct.1_Missense_Mutation_p.S98T|CSH1_uc002jcu.1_Missense_Mutation_p.S132T|CSH1_uc002jcv.1_Intron|CSH1_uc002jcw.2_Missense_Mutation_p.S132T|CSH1_uc002jcy.2_3'UTR	NM_001317	NP_001308	P01243	CSH_HUMAN	chorionic somatomammotropin hormone 1 isoform 1	132					female pregnancy|signal transduction	extracellular region	hormone activity|metal ion binding			skin(1)	1						TCGCTGTCCGAGGTGTCATAC	0.592		NA							Russell-Silver_syndrome				17	31					0	0	0	0
ABCA6	23460	broad.mit.edu	37	17	67136824	67136824	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr17:67136824G>T	uc002jhw.1	-	2	196	c.21C>A	c.(19-21)AGC>AGA	p.S7R	ABCA6_uc002jhy.2_Missense_Mutation_p.S5R	NM_080284	NP_525023	Q8N139	ABCA6_HUMAN	ATP-binding cassette, sub-family A, member 6	7					transport	integral to membrane	ATP binding|ATPase activity			upper_aerodigestive_tract(2)|large_intestine(2)|ovary(2)|skin(1)	7	Breast(10;5.65e-12)					GCTGATACACGCTTTTCTGTT	0.333		NA											23	52					7.88e-14	1.04e-13	1	0
C17orf77	146723	broad.mit.edu	37	17	72588218	72588218	+	Silent	SNP	A	A	T			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr17:72588218A>T	uc002jla.1	+	3	395	c.33A>T	c.(31-33)ACA>ACT	p.T11T	CD300LD_uc002jkz.2_Intron	NM_152460	NP_689673	Q96MU5	CQ077_HUMAN	hypothetical protein LOC146723	11						extracellular region					0						TTTCCCTGACATGTCTCCTTC	0.478		NA											48	92					0	0	0	0
DLGAP1	9229	broad.mit.edu	37	18	3879384	3879384	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr18:3879384C>G	uc002kmf.2	-	1	752	c.685G>C	c.(685-687)GAC>CAC	p.D229H	DLGAP1_uc010wyz.1_Missense_Mutation_p.D229H|DLGAP1_uc002kmk.2_Missense_Mutation_p.D229H|uc002kml.1_Intron	NM_004746	NP_004737	O14490	DLGP1_HUMAN	discs large homolog-associated protein 1 isoform	229					synaptic transmission	cell junction|postsynaptic density|postsynaptic membrane				ovary(2)|pancreas(1)|skin(1)	4		Colorectal(8;0.0257)				GCCGAGCGGTCGGGGCACCTG	0.647		NA											152	187					0	0	0	0
DLGAP1	9229	broad.mit.edu	37	18	3879506	3879506	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr18:3879506C>G	uc002kmf.2	-	1	630	c.563G>C	c.(562-564)CGC>CCC	p.R188P	DLGAP1_uc010wyz.1_Missense_Mutation_p.R188P|DLGAP1_uc002kmk.2_Missense_Mutation_p.R188P|uc002kml.1_Intron	NM_004746	NP_004737	O14490	DLGP1_HUMAN	discs large homolog-associated protein 1 isoform	188					synaptic transmission	cell junction|postsynaptic density|postsynaptic membrane		p.R188C(1)		ovary(2)|pancreas(1)|skin(1)	4		Colorectal(8;0.0257)				GGGCTCCGCGCGCCGCTCCTT	0.711		NA											53	258					0	0	0	0
ASXL3	80816	broad.mit.edu	37	18	31224903	31224903	+	Silent	SNP	C	C	T			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr18:31224903C>T	uc010dmg.1	+	3	238	c.183C>T	c.(181-183)AAC>AAT	p.N61N	ASXL3_uc002kxq.2_5'UTR	NM_030632	NP_085135	Q9C0F0	ASXL3_HUMAN	additional sex combs like 3	61					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding			ovary(2)|pancreas(1)	3						TTCACACTAACACTCGAATAG	0.393		NA											3	8					0	0	0	0
SETBP1	26040	broad.mit.edu	37	18	42532199	42532199	+	Missense_Mutation	SNP	A	A	G			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr18:42532199A>G	uc010dni.2	+	4	3190	c.2894A>G	c.(2893-2895)CAA>CGA	p.Q965R		NM_015559	NP_056374	Q9Y6X0	SETBP_HUMAN	SET binding protein 1 isoform a	965						nucleus	DNA binding			upper_aerodigestive_tract(2)|large_intestine(1)	3				Colorectal(1;0.0622)|COAD - Colon adenocarcinoma(74;0.201)		ACCAAGTTCCAAGTGTTCAGA	0.473		NA							Schinzel-Giedion_syndrome				52	58					0	0	0	0
SLC14A1	6563	broad.mit.edu	37	18	43316445	43316445	+	Silent	SNP	T	T	C			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr18:43316445T>C	uc010xcn.1	+	7	814	c.495T>C	c.(493-495)AAT>AAC	p.N165N	SLC14A1_uc010dnk.2_Silent_p.N221N|SLC14A1_uc002lbf.3_Silent_p.N165N|SLC14A1_uc002lbg.3_Intron|SLC14A1_uc010xco.1_Silent_p.N60N|SLC14A1_uc002lbh.3_Silent_p.N57N|SLC14A1_uc002lbi.3_Silent_p.N33N|SLC14A1_uc002lbj.3_Silent_p.N221N|SLC14A1_uc002lbk.3_Silent_p.N165N	NM_001146036	NP_001139508	Q13336	UT1_HUMAN	solute carrier family 14 (urea transporter),	165						integral to plasma membrane	urea transmembrane transporter activity			central_nervous_system(1)|pancreas(1)	2						GTGCATTGAATTCCATGCTCA	0.458		NA											34	114					0	0	0	0
TCEB3C	162699	broad.mit.edu	37	18	44555173	44555173	+	Silent	SNP	G	G	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr18:44555173G>A	uc010xdb.1	-	1	1277	c.1041C>T	c.(1039-1041)AAC>AAT	p.N347N	KATNAL2_uc010dnq.1_Intron|KATNAL2_uc002lco.2_Intron|KATNAL2_uc002lcp.3_Intron	NM_145653	NP_663628	Q8NG57	ELOA3_HUMAN	transcription elongation factor B polypeptide	347	Activation domain (By similarity).				regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to membrane|nucleus	DNA binding				0						CGTCCGGATTGTTCCTAGGCA	0.647		NA											29	607					0	0	0	0
MBD1	4152	broad.mit.edu	37	18	47806252	47806252	+	Splice_Site	SNP	C	C	T			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr18:47806252C>T	uc010dow.1	-	2	547	c.110_splice	c.e2+1	p.S37_splice	MBD1_uc002lef.2_5'Flank|MBD1_uc002leg.2_Splice_Site_p.S37_splice|MBD1_uc010xdi.1_Splice_Site_p.S63_splice|MBD1_uc002leh.3_Splice_Site_p.S37_splice|MBD1_uc002len.2_Splice_Site_p.S37_splice|MBD1_uc002lei.3_Splice_Site_p.S37_splice|MBD1_uc002lej.3_Splice_Site_p.S37_splice|MBD1_uc002lek.3_Splice_Site_p.S37_splice|MBD1_uc002lel.3_Splice_Site_p.S37_splice|MBD1_uc002lem.3_Splice_Site_p.S37_splice|MBD1_uc010xdj.1_Splice_Site_p.S37_splice|MBD1_uc010xdk.1_Splice_Site_p.S37_splice|MBD1_uc010dox.1_Intron|MBD1_uc002leo.2_Splice_Site_p.S37_splice	NM_015846	NP_056671	Q9UIS9	MBD1_HUMAN	methyl-CpG binding domain protein 1 isoform 1						negative regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	chromosome|nuclear speck	methyl-CpG binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2						CCACCCAGTACCTCTGGTAAT	0.537		NA											16	50					0	0	0	0
MRO	83876	broad.mit.edu	37	18	48331580	48331580	+	Missense_Mutation	SNP	C	C	T	rs143359256	by1000genomes	TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr18:48331580C>T	uc002lew.3	-	5	667	c.373G>A	c.(373-375)GGT>AGT	p.G125S	MRO_uc010xdn.1_Missense_Mutation_p.G125S|MRO_uc010dpa.2_Missense_Mutation_p.G139S|MRO_uc010dpb.2_Missense_Mutation_p.G139S|MRO_uc010dpc.2_Missense_Mutation_p.G125S|MRO_uc002lex.3_Missense_Mutation_p.G125S	NM_031939	NP_114145	Q9BYG7	MSTRO_HUMAN	maestro isoform a	125						nucleolus	binding				0		Colorectal(6;0.0596)		Colorectal(21;0.082)		GAACCCAAACCTTTCCCCTGG	0.433		NA											50	45					0	0	0	0
DCC	1630	broad.mit.edu	37	18	50450211	50450211	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr18:50450211G>A	uc002lfe.1	+	4	1419	c.832G>A	c.(832-834)GAA>AAA	p.E278K	DCC_uc010xdr.1_Missense_Mutation_p.E126K	NM_005215	NP_005206	P43146	DCC_HUMAN	netrin receptor DCC precursor	278	Extracellular (Potential).|Ig-like C2-type 3.				apoptosis|induction of apoptosis|negative regulation of collateral sprouting|negative regulation of dendrite development	cytosol|integral to membrane				skin(8)|ovary(6)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	17		all_cancers(7;0.11)|all_epithelial(6;0.00126)		Colorectal(16;0.0251)|COAD - Colon adenocarcinoma(17;0.0942)		ACGAGGCGAGGAAGTCATCCA	0.368		NA											41	48					0	0	0	0
CDH19	28513	broad.mit.edu	37	18	64239255	64239255	+	Missense_Mutation	SNP	T	T	C			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr18:64239255T>C	uc002lkc.1	-	2	325	c.187A>G	c.(187-189)ATC>GTC	p.I63V	CDH19_uc010dql.1_RNA|CDH19_uc010xey.1_Missense_Mutation_p.I63V|CDH19_uc002lkd.2_Missense_Mutation_p.I63V	NM_021153	NP_066976	Q9H159	CAD19_HUMAN	cadherin 19, type 2 preproprotein	63	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(1)|skin(1)	2		Esophageal squamous(42;0.0132)				ACCTGGCCGATGTGATGACTA	0.378		NA											17	38					0	0	0	0
CNDP1	84735	broad.mit.edu	37	18	72247448	72247448	+	Missense_Mutation	SNP	C	C	G	rs144587048		TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr18:72247448C>G	uc002llq.2	+	10	1461	c.1250C>G	c.(1249-1251)CCG>CGG	p.P417R	CNDP1_uc002lls.2_Missense_Mutation_p.P220R	NM_032649	NP_116038	Q96KN2	CNDP1_HUMAN	carnosinase 1 precursor	417					proteolysis	extracellular region	carboxypeptidase activity|dipeptidase activity|metal ion binding|metallopeptidase activity|tripeptidase activity				0		Esophageal squamous(42;0.129)|Prostate(75;0.157)|Melanoma(33;0.211)		BRCA - Breast invasive adenocarcinoma(31;0.109)		GGACTACACCCGTGGATTGCA	0.443		NA											12	36					0	0	0	0
NFATC1	4772	broad.mit.edu	37	18	77170505	77170505	+	Missense_Mutation	SNP	C	C	T	rs143045693		TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr18:77170505C>T	uc010xfg.1	+	2	683	c.230C>T	c.(229-231)CCG>CTG	p.P77L	NFATC1_uc002lnc.1_Missense_Mutation_p.P77L|NFATC1_uc010xff.1_Missense_Mutation_p.P77L|NFATC1_uc002lnd.2_Missense_Mutation_p.P77L|NFATC1_uc002lne.2_Intron|NFATC1_uc010xfh.1_Missense_Mutation_p.P77L|NFATC1_uc010xfi.1_Missense_Mutation_p.P64L|NFATC1_uc010xfj.1_Intron|NFATC1_uc002lnf.2_Missense_Mutation_p.P64L|NFATC1_uc002lng.2_Missense_Mutation_p.P64L|NFATC1_uc010xfk.1_Missense_Mutation_p.P64L	NM_006162	NP_006153	O95644	NFAC1_HUMAN	nuclear factor of activated T-cells, cytosolic	77					intracellular signal transduction|positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|nucleus	FK506 binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			large_intestine(1)|ovary(1)	2		Esophageal squamous(42;0.0157)|Melanoma(33;0.144)		OV - Ovarian serous cystadenocarcinoma(15;3.73e-07)|BRCA - Breast invasive adenocarcinoma(31;0.0257)		ACCTCCACACCGGGCATCATC	0.692		NA											32	37					0	0	0	0
ELANE	1991	broad.mit.edu	37	19	852883	852883	+	Silent	SNP	G	G	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr19:852883G>A	uc002lqb.2	+	2	113	c.75G>A	c.(73-75)GCG>GCA	p.A25A		NM_001972	NP_001963	P08246	ELNE_HUMAN	neutrophil elastase preproprotein	25			A -> V (in SCN1).		cellular calcium ion homeostasis|negative regulation of chemokine biosynthetic process|negative regulation of chemotaxis|negative regulation of inflammatory response|negative regulation of interleukin-8 biosynthetic process|positive regulation of interleukin-8 biosynthetic process|positive regulation of MAP kinase activity|positive regulation of smooth muscle cell proliferation|protein catabolic process|proteolysis|response to UV	cell surface|extracellular region|stored secretory granule	bacterial cell surface binding|cytokine binding|heparin binding			pancreas(1)	1					Alpha-1-proteinase inhibitor(DB00058)|Filgrastim(DB00099)|Pegfilgrastim(DB00019)	CAGGCACCGCGCTGGCCTCGG	0.741		NA							Kostmann_syndrome				11	8					0	0	0	0
APC2	10297	broad.mit.edu	37	19	1466497	1466497	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr19:1466497C>T	uc002lsr.1	+	15	3405	c.3197C>T	c.(3196-3198)TCG>TTG	p.S1066L	APC2_uc002lss.1_Missense_Mutation_p.S648L|APC2_uc002lst.1_Missense_Mutation_p.S1066L|APC2_uc002lsu.1_Missense_Mutation_p.S1065L|C19orf25_uc010xgn.1_Intron	NM_005883	NP_005874	O95996	APC2_HUMAN	adenomatosis polyposis coli 2	1066	Interaction with CTNNB1.|1.|5 X 20 AA approximate repeat of F-X-V-E- X-T-P-X-C-F-S-R-X-S-S-L-S-S-L-S.				negative regulation of canonical Wnt receptor signaling pathway|negative regulation of catenin import into nucleus|Wnt receptor signaling pathway	actin filament|catenin complex|cytoplasmic microtubule|Golgi membrane|lamellipodium membrane|perinuclear region of cytoplasm	beta-catenin binding|microtubule binding			breast(3)|pancreas(1)	4		Acute lymphoblastic leukemia(61;3.02e-13)|all_hematologic(61;4.32e-09)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GGGCCACTCTCGCTGTCCCGA	0.682		NA											5	10					0	0	0	0
MUC16	94025	broad.mit.edu	37	19	9070007	9070007	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr19:9070007C>G	uc002mkp.2	-	3	17643	c.17439G>C	c.(17437-17439)GAG>GAC	p.E5813D		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	5815	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						TCCTGGAGACCTCAGTAGTAG	0.493		NA											21	75					0	0	0	0
MUC16	94025	broad.mit.edu	37	19	9075389	9075389	+	Silent	SNP	G	G	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr19:9075389G>A	uc002mkp.2	-	3	12261	c.12057C>T	c.(12055-12057)GAC>GAT	p.D4019D		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	4021	Thr-rich.|Extracellular (Potential).|Ser-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						AAGGGCTGACGTCCCTCAGTT	0.473		NA											27	56					0	0	0	0
DNM2	1785	broad.mit.edu	37	19	10893766	10893766	+	Silent	SNP	C	C	T			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr19:10893766C>T	uc002mps.1	+	6	983	c.819C>T	c.(817-819)GGC>GGT	p.G273G	DNM2_uc010dxk.2_RNA|DNM2_uc002mpt.1_Silent_p.G273G|DNM2_uc002mpv.1_Silent_p.G273G|DNM2_uc002mpu.1_Silent_p.G273G|DNM2_uc010dxl.1_Silent_p.G273G|DNM2_uc002mpw.2_Silent_p.G6G	NM_001005361	NP_001005361	P50570	DYN2_HUMAN	dynamin 2 isoform 2	273					G2/M transition of mitotic cell cycle|positive regulation of apoptosis|positive regulation of transcription, DNA-dependent|post-Golgi vesicle-mediated transport|receptor internalization|signal transduction|synaptic vesicle transport|transferrin transport	cell junction|cytosol|Golgi membrane|microtubule|postsynaptic density|postsynaptic membrane	GTP binding|GTPase activity|microtubule binding			central_nervous_system(2)|skin(2)|ovary(1)|breast(1)	6			Epithelial(33;4.17e-05)|all cancers(31;8.48e-05)			ACCGCATGGGCACGCCACATC	0.577		NA											15	47					0	0	0	0
ZNF443	10224	broad.mit.edu	37	19	12542408	12542408	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr19:12542408C>G	uc002mtu.2	-	4	776	c.578G>C	c.(577-579)GGA>GCA	p.G193A		NM_005815	NP_005806	Q9Y2A4	ZN443_HUMAN	zinc finger protein 443	193					induction of apoptosis|regulation of transcription, DNA-dependent|response to stress|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			pancreas(1)	1						AGGTCCATCTCCACGCTGCAC	0.418		NA											36	93					0	0	0	0
CCDC130	81576	broad.mit.edu	37	19	13869957	13869957	+	Silent	SNP	G	G	T			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr19:13869957G>T	uc002mxb.1	+	9	947	c.444G>T	c.(442-444)CGG>CGT	p.R148R	CCDC130_uc010xnf.1_3'UTR|CCDC130_uc002mxc.1_Silent_p.R148R|CCDC130_uc002mxd.1_Silent_p.R3R|CCDC130_uc010dzf.1_Silent_p.R42R	NM_030818	NP_110445	P13994	CC130_HUMAN	coiled-coil domain containing 130	148					response to virus		protein binding				0			OV - Ovarian serous cystadenocarcinoma(19;6.02e-23)|Epithelial(5;2.58e-18)			CCATGTTCCGGCTGGAGCATG	0.652		NA											4	10					0.00909568	0.00946794	1	0
RFX1	5989	broad.mit.edu	37	19	14104570	14104570	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr19:14104570G>A	uc002mxv.2	-	2	358	c.86C>T	c.(85-87)CCG>CTG	p.P29L	RFX1_uc010dzi.2_Missense_Mutation_p.P29L	NM_002918	NP_002909	P22670	RFX1_HUMAN	regulatory factor X1	29					immune response	nucleus	DNA binding|protein binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity			lung(1)|pancreas(1)	2			OV - Ovarian serous cystadenocarcinoma(19;6.67e-23)			tggcggtggcggctggggctg	0.129		NA											5	15					0	0	0	0
FCHO1	23149	broad.mit.edu	37	19	17887482	17887482	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr19:17887482C>G	uc010ebb.2	+	17	1435	c.1246C>G	c.(1246-1248)CCC>GCC	p.P416A	FCHO1_uc002nhg.3_Missense_Mutation_p.P416A|FCHO1_uc002nhh.2_Missense_Mutation_p.P416A|FCHO1_uc010xpw.1_Missense_Mutation_p.P366A|FCHO1_uc002nhi.2_5'Flank|FCHO1_uc002nhj.2_5'Flank	NM_001161358	NP_001154830	O14526	FCHO1_HUMAN	FCH domain only 1 isoform b	416										breast(1)	1						TCGGTCTGCCCCCAGAACCAG	0.597		NA											13	41					0	0	0	0
ZNF90	7643	broad.mit.edu	37	19	20229413	20229413	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr19:20229413C>A	uc002nor.2	+	4	1189	c.1050C>A	c.(1048-1050)TTC>TTA	p.F350L	ZNF90_uc002nos.1_Intron|ZNF90_uc002not.1_Intron	NM_007138	NP_009069	Q03938	ZNF90_HUMAN	zinc finger protein 90	350	C2H2-type 7.					Golgi apparatus|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|skin(1)	2						GCAAAGCCTTCAGGCGCTCCT	0.423		NA											14	23					6.82e-15	9.15e-15	1	0
ZNF430	80264	broad.mit.edu	37	19	21205625	21205625	+	Nonsense_Mutation	SNP	A	A	T			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr19:21205625A>T	uc002npj.2	+	2	144	c.34A>T	c.(34-36)AAG>TAG	p.K12*	ZNF430_uc002npk.2_Nonsense_Mutation_p.K12*	NM_025189	NP_079465	Q9H8G1	ZN430_HUMAN	zinc finger protein 430	12					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(2)	2						GTATCCTCTCAAGGAAGCAAG	0.448		NA											33	74					0	0	0	0
ZNF208	7757	broad.mit.edu	37	19	22154585	22154585	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr19:22154585G>T	uc002nqp.2	-	6	3016	c.2867C>A	c.(2866-2868)CCC>CAC	p.P956H	ZNF208_uc002nqo.1_Intron	NM_007153	NP_009084			zinc finger protein 208											ovary(5)|skin(2)	7		all_lung(12;0.0961)|Lung NSC(12;0.103)				ACATTTGTAGGGTTCCTCTCC	0.428		NA											36	86					1.03e-13	1.37e-13	1	0
ZNF676	163223	broad.mit.edu	37	19	22363718	22363718	+	Silent	SNP	G	G	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr19:22363718G>A	uc002nqs.1	-	3	1119	c.801C>T	c.(799-801)ACC>ACT	p.T267T		NM_001001411	NP_001001411	Q8N7Q3	ZN676_HUMAN	zinc finger protein 676	267	C2H2-type 4.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.114)				GTGTATTAAGGGTTGAGACGC	0.388		NA											23	60					0	0	0	0
LGI4	163175	broad.mit.edu	37	19	35617862	35617862	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr19:35617862G>A	uc002nxx.2	-	7	1282	c.688C>T	c.(688-690)CAA>TAA	p.Q230*	LGI4_uc002nxy.1_Nonsense_Mutation_p.Q58*|LGI4_uc002nxz.1_Nonsense_Mutation_p.Q58*	NM_139284	NP_644813	Q8N135	LGI4_HUMAN	leucine-rich repeat LGI family, member 4	230	EAR 1.					extracellular region				pancreas(1)	1	all_lung(56;7.56e-09)|Lung NSC(56;1.1e-08)|Esophageal squamous(110;0.162)		Epithelial(14;5.54e-20)|OV - Ovarian serous cystadenocarcinoma(14;1.33e-18)|all cancers(14;4.27e-17)|LUSC - Lung squamous cell carcinoma(66;0.0849)			GGCTCCCCTTGGTAGGAGAAG	0.652		NA											15	43					0	0	0	0
ZNF568	374900	broad.mit.edu	37	19	37488355	37488355	+	Nonsense_Mutation	SNP	G	G	T			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr19:37488355G>T	uc010efg.2	+	10	2277	c.1720G>T	c.(1720-1722)GAG>TAG	p.E574*	ZNF568_uc010xtn.1_Nonsense_Mutation_p.E512*|uc010efi.2_Nonsense_Mutation_p.E392*|uc010efj.2_Nonsense_Mutation_p.E392*			Q3ZCX4	ZN568_HUMAN	SubName: Full=cDNA FLJ57578, moderately similar to Mus musculus zinc finger protein 568 (Zfp568), mRNA;	611					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)|ovary(1)	2	Esophageal squamous(110;0.183)		COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			TCACACTGGGGAGAGACCCCA	0.448		NA											5	13					0.000602214	0.000648391	1	0
RYR1	6261	broad.mit.edu	37	19	38948913	38948913	+	Missense_Mutation	SNP	T	T	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr19:38948913T>A	uc002oit.2	+	18	2278	c.2148T>A	c.(2146-2148)GAT>GAA	p.D716E	RYR1_uc002oiu.2_Missense_Mutation_p.D716E	NM_000540	NP_000531	P21817	RYR1_HUMAN	skeletal muscle ryanodine receptor isoform 1	716	Cytoplasmic.|B30.2/SPRY 1.				muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(7)|pancreas(2)|breast(1)|central_nervous_system(1)|skin(1)	12	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	ACGGCTTTGATGGACTGCATC	0.632		NA											23	79					0	0	0	0
DYRK1B	9149	broad.mit.edu	37	19	40317964	40317964	+	Silent	SNP	C	C	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr19:40317964C>A	uc002omj.2	-	8	1336	c.1056G>T	c.(1054-1056)GGG>GGT	p.G352G	DYRK1B_uc002omi.2_Silent_p.G352G|DYRK1B_uc002omk.2_Silent_p.G352G	NM_004714	NP_004705	Q9Y463	DYR1B_HUMAN	dual-specificity tyrosine-(Y)-phosphorylation	352	Protein kinase.				positive regulation of transcription, DNA-dependent	nucleus	ATP binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|transcription coactivator activity			ovary(4)|stomach(1)|central_nervous_system(1)|skin(1)	7	all_cancers(60;5.79e-06)|all_lung(34;5.2e-08)|Lung NSC(34;6.14e-08)|Ovarian(47;0.06)		Epithelial(26;5.74e-25)|OV - Ovarian serous cystadenocarcinoma(5;3.13e-24)|all cancers(26;8.59e-23)			TCCAGCCACCCCCAGGCAGCC	0.647		NA											14	23					6.72e-11	8.57e-11	1	0
HNRNPUL1	11100	broad.mit.edu	37	19	41809959	41809959	+	Missense_Mutation	SNP	A	A	T			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr19:41809959A>T	uc002oqb.3	+	13	2344	c.2055A>T	c.(2053-2055)AGA>AGT	p.R685S	CYP2F1_uc010xvw.1_Intron|HNRNPUL1_uc002opz.3_Missense_Mutation_p.R585S|HNRNPUL1_uc002oqa.3_Missense_Mutation_p.R585S|HNRNPUL1_uc010ehm.2_Missense_Mutation_p.R685S|HNRNPUL1_uc002oqc.3_Missense_Mutation_p.R571S|HNRNPUL1_uc002oqe.3_Intron|HNRNPUL1_uc002oqd.3_Missense_Mutation_p.R585S|HNRNPUL1_uc010ehn.2_Missense_Mutation_p.R585S|HNRNPUL1_uc010eho.2_Missense_Mutation_p.R585S|HNRNPUL1_uc010xvy.1_Missense_Mutation_p.R585S|HNRNPUL1_uc010ehp.2_Missense_Mutation_p.R541S|HNRNPUL1_uc002oqf.3_Missense_Mutation_p.R209S	NM_007040	NP_008971	Q9BUJ2	HNRL1_HUMAN	heterogeneous nuclear ribonucleoprotein U-like 1	685	Necessary for interaction with TP53.|Asn-rich.				nuclear mRNA splicing, via spliceosome|regulation of transcription, DNA-dependent|response to virus|transcription, DNA-dependent	heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	enzyme binding|RNA binding			central_nervous_system(1)|skin(1)	2						CCAACAACAGAGGCAGCTACA	0.388		NA											37	56					0	0	0	0
EXOC3L2	90332	broad.mit.edu	37	19	45731307	45731307	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr19:45731307G>A	uc002pay.1	-	4	259	c.218C>T	c.(217-219)GCA>GTA	p.A73V		NM_138568	NP_612635	Q2M3D2	EX3L2_HUMAN	exocyst complex component 3-like 2	73										ovary(1)	1		all_neural(266;0.224)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.00883)		GATGCGGGGTGCTCGCTCTGT	0.637		NA											8	26					0	0	0	0
GRLF1	2909	broad.mit.edu	37	19	47422368	47422368	+	Nonsense_Mutation	SNP	G	G	T			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr19:47422368G>T	uc010ekv.2	+	1	436	c.436G>T	c.(436-438)GAG>TAG	p.E146*		NM_004491	NP_004482	Q9NRY4	RHG35_HUMAN	glucocorticoid receptor DNA binding factor 1	146					axon guidance|negative regulation of transcription, DNA-dependent|small GTPase mediated signal transduction|transcription, DNA-dependent	cytosol	DNA binding|Rho GTPase activator activity|transcription corepressor activity			central_nervous_system(1)	1		all_cancers(25;1.51e-09)|all_epithelial(76;1.87e-07)|all_lung(116;7.86e-06)|Lung NSC(112;2.31e-05)|Ovarian(192;0.0129)|all_neural(266;0.026)|Breast(70;0.077)		all cancers(93;2.03e-05)|OV - Ovarian serous cystadenocarcinoma(262;2.57e-05)|Epithelial(262;0.00135)|GBM - Glioblastoma multiforme(486;0.0289)		GCAGGACTTTGAGCAGAAACA	0.483		NA											26	45					7.93e-12	1.02e-11	1	0
CCDC155	147872	broad.mit.edu	37	19	49902726	49902726	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr19:49902726C>G	uc002pnm.1	+	9	934	c.760C>G	c.(760-762)CAG>GAG	p.Q254E	CCDC155_uc002pnl.1_Missense_Mutation_p.Q254E|CCDC155_uc010emx.1_Missense_Mutation_p.Q227E	NM_144688	NP_653289	Q8N6L0	CC155_HUMAN	coiled-coil domain containing 155	254	Potential.					integral to membrane	calcium ion binding			ovary(1)|central_nervous_system(1)	2						AAAGGAGCAGCAGCATCTGGT	0.572		NA											7	9					0	0	0	0
HAS1	3036	broad.mit.edu	37	19	52222623	52222623	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr19:52222623C>A	uc002pxo.1	-	2	573	c.538G>T	c.(538-540)GCC>TCC	p.A180S	HAS1_uc010epc.1_5'Flank|HAS1_uc010epd.1_Missense_Mutation_p.A145S|HAS1_uc002pxn.1_Missense_Mutation_p.A187S|HAS1_uc002pxp.1_Missense_Mutation_p.A179S	NM_001523	NP_001514	Q92839	HAS1_HUMAN	hyaluronan synthase 1	180	Cytoplasmic (Potential).				cell adhesion	integral to plasma membrane	hyaluronan synthase activity|protein binding			ovary(1)|pancreas(1)	2		all_neural(266;0.0189)|Medulloblastoma(540;0.146)		GBM - Glioblastoma multiforme(134;0.00102)|OV - Ovarian serous cystadenocarcinoma(262;0.0177)		TAGGCTccggcgcccaccgcg	0.587		NA											3	8					0.004672	0.0049279	1	0
FPR2	2358	broad.mit.edu	37	19	52272136	52272136	+	Silent	SNP	G	G	C	rs147854636		TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr19:52272136G>C	uc002pxr.2	+	2	270	c.225G>C	c.(223-225)ACG>ACC	p.T75T	FPR2_uc002pxs.3_Silent_p.T75T|FPR2_uc010epf.2_Silent_p.T75T	NM_001005738	NP_001005738	P25090	FPR2_HUMAN	formyl peptide receptor-like 1	75	Helical; Name=2; (Potential).				cell adhesion|cellular component movement|chemotaxis|inflammatory response	integral to membrane|plasma membrane	N-formyl peptide receptor activity			lung(3)|ovary(1)	4						TTTCTTTCACGGCCACATTAC	0.512		NA											28	88					0	0	0	0
PTPRH	5794	broad.mit.edu	37	19	55707974	55707974	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr19:55707974G>A	uc002qjq.2	-	10	2246	c.2173C>T	c.(2173-2175)CGG>TGG	p.R725W	PTPRH_uc010esv.2_Missense_Mutation_p.R547W|PTPRH_uc002qjs.2_Missense_Mutation_p.R732W	NM_002842	NP_002833	Q9HD43	PTPRH_HUMAN	protein tyrosine phosphatase, receptor type, H	725	Extracellular (Potential).|Fibronectin type-III 8.				apoptosis	cytoplasm|integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			ovary(2)|large_intestine(1)|skin(1)	4		Renal(1328;0.245)	BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0479)		GGGTAGGACCGAGCCGGCCCG	0.632		NA											29	44					0	0	0	0
BRSK1	84446	broad.mit.edu	37	19	55817783	55817783	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr19:55817783G>A	uc002qkg.2	+	17	2331	c.2054G>A	c.(2053-2055)GGT>GAT	p.G685D	BRSK1_uc002qkf.2_Missense_Mutation_p.G701D|BRSK1_uc002qkh.2_Missense_Mutation_p.G380D	NM_032430	NP_115806	Q8TDC3	BRSK1_HUMAN	BR serine/threonine kinase 1	685					establishment of cell polarity|G2/M transition DNA damage checkpoint|neuron differentiation|response to UV	cell junction|cytoplasm|nucleus	magnesium ion binding|protein serine/threonine kinase activity			ovary(2)|stomach(1)|lung(1)|breast(1)|skin(1)	6		Renal(1328;0.245)	BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0474)		AGCGGAGGTGGTGGCATCTAC	0.642		NA											9	33					0	0	0	0
ZNF256	10172	broad.mit.edu	37	19	58453833	58453833	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr19:58453833G>T	uc002qqu.2	-	3	578	c.343C>A	c.(343-345)CAG>AAG	p.Q115K	ZNF256_uc010euj.2_5'UTR	NM_005773	NP_005764	Q9Y2P7	ZN256_HUMAN	zinc finger protein 256	115					multicellular organismal development|negative regulation of transcription, DNA-dependent	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			upper_aerodigestive_tract(1)|skin(1)	2		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0155)		TACAGTTTCTGACCATGGTGT	0.473		NA											42	103					3.67e-30	5.32e-30	1	0
ZNF324	25799	broad.mit.edu	37	19	58983146	58983146	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr19:58983146G>C	uc002qsw.1	+	4	1381	c.1287G>C	c.(1285-1287)CAG>CAC	p.Q429H	ZNF324_uc002qsx.1_Missense_Mutation_p.Q206H	NM_014347	NP_055162	O75467	Z324A_HUMAN	zinc finger protein 324	429	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_cancers(17;1.81e-17)|all_epithelial(17;1.21e-12)|Lung NSC(17;2.8e-05)|all_lung(17;0.000139)|Colorectal(82;0.000147)|Renal(17;0.00528)|all_neural(62;0.0133)|Ovarian(87;0.156)|Medulloblastoma(540;0.232)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0164)|Lung(386;0.179)		CCTGCCCACAGTGCGGCCGCG	0.677		NA											14	31					0	0	0	0
TPO	7173	broad.mit.edu	37	2	1457542	1457542	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr2:1457542C>A	uc002qww.2	+	6	650	c.559C>A	c.(559-561)CAG>AAG	p.Q187K	TPO_uc010ewj.2_Intron|TPO_uc002qwu.2_Missense_Mutation_p.Q187K|TPO_uc002qwr.2_Missense_Mutation_p.Q187K|TPO_uc002qwx.2_Missense_Mutation_p.Q187K|TPO_uc010yio.1_Missense_Mutation_p.Q187K|TPO_uc010yip.1_Missense_Mutation_p.Q187K	NM_000547	NP_000538	P07202	PERT_HUMAN	thyroid peroxidase isoform a	187	Extracellular (Potential).				cellular nitrogen compound metabolic process|hormone biosynthetic process|hydrogen peroxide catabolic process	cell surface|cytoplasm|integral to plasma membrane	calcium ion binding|heme binding|iodide peroxidase activity			ovary(7)|pancreas(6)|skin(5)|lung(1)|kidney(1)	20	all_hematologic(175;0.0487)|Acute lymphoblastic leukemia(172;0.0627)	all_cancers(51;0.0338)		all cancers(51;0.0356)|OV - Ovarian serous cystadenocarcinoma(76;0.0748)|Epithelial(75;0.12)	Carbimazole(DB00389)|Methimazole(DB00763)|Propylthiouracil(DB00550)	CGGCTTCAGTCAGCCCCGAGG	0.602		NA											29	60					7.42e-09	9.08e-09	1	0
PXDN	7837	broad.mit.edu	37	2	1684055	1684055	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr2:1684055C>G	uc002qxa.2	-	7	704	c.640G>C	c.(640-642)GGG>CGG	p.G214R	PXDN_uc002qxb.1_Missense_Mutation_p.G214R|PXDN_uc002qxc.1_Missense_Mutation_p.G31R	NM_012293	NP_036425	Q92626	PXDN_HUMAN	peroxidasin precursor	214	LRRCT.				extracellular matrix organization|hydrogen peroxide catabolic process|immune response	endoplasmic reticulum|extracellular space|proteinaceous extracellular matrix	extracellular matrix structural constituent|heme binding|interleukin-1 receptor antagonist activity|peroxidase activity			pancreas(6)|ovary(2)	8	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.0845)|Lung NSC(108;0.00641)|all_epithelial(98;0.00716)		all cancers(51;0.0492)|OV - Ovarian serous cystadenocarcinoma(76;0.0973)|Epithelial(75;0.17)|GBM - Glioblastoma multiforme(21;0.228)		TGCGCGTTCCCCGACTCCGCG	0.582		NA											11	24					0	0	0	0
ATP6V1C2	245973	broad.mit.edu	37	2	10923308	10923308	+	Silent	SNP	G	G	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr2:10923308G>A	uc002ras.2	+	14	1312	c.1203G>A	c.(1201-1203)GTG>GTA	p.V401V	ATP6V1C2_uc002rat.2_Silent_p.V355V	NM_001039362	NP_001034451	Q8NEY4	VATC2_HUMAN	vacuolar H+ ATPase C2 isoform a	401					ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|insulin receptor signaling pathway|transferrin transport	cytosol|proton-transporting V-type ATPase, V1 domain				ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.191)			Epithelial(75;0.15)|OV - Ovarian serous cystadenocarcinoma(76;0.152)		AGGCATCTGTGGAGATCCCGG	0.443		NA											20	45					0	0	0	0
APOB	338	broad.mit.edu	37	2	21231404	21231404	+	Missense_Mutation	SNP	T	T	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr2:21231404T>A	uc002red.2	-	26	8464	c.8336A>T	c.(8335-8337)AAT>ATT	p.N2779I		NM_000384	NP_000375	P04114	APOB_HUMAN	apolipoprotein B precursor	2779					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			ovary(11)|skin(9)|central_nervous_system(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	GGTGGTTCCATTCCCTATGTC	0.398		NA											40	65					0	0	0	0
XDH	7498	broad.mit.edu	37	2	31598392	31598392	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr2:31598392C>A	uc002rnv.1	-	15	1535	c.1456G>T	c.(1456-1458)GTG>TTG	p.V486L		NM_000379	NP_000370	P47989	XDH_HUMAN	xanthine dehydrogenase	486					purine nucleotide catabolic process|xanthine catabolic process	cytosol|extracellular region|peroxisome	2 iron, 2 sulfur cluster binding|electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|molybdopterin cofactor binding|protein homodimerization activity|xanthine dehydrogenase activity|xanthine oxidase activity			skin(4)|breast(2)|ovary(1)|central_nervous_system(1)	8	Acute lymphoblastic leukemia(172;0.155)				Allopurinol(DB00437)|Carvedilol(DB01136)|Daunorubicin(DB00694)|Deferoxamine(DB00746)|Desflurane(DB01189)|Menadione(DB00170)|Mercaptopurine(DB01033)|Methotrexate(DB00563)|NADH(DB00157)|Nitrofurazone(DB00336)|Papaverine(DB01113)|Procarbazine(DB01168)|Pyrazinamide(DB00339)|Rasburicase(DB00049)|Spermine(DB00127)|Trifluoperazine(DB00831)|Vitamin E(DB00163)	CCTGCACACACGTCCTGCAGC	0.637		NA											18	26					1.68e-08	2.04e-08	1	0
THUMPD2	80745	broad.mit.edu	37	2	39971589	39971589	+	Missense_Mutation	SNP	T	T	C			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr2:39971589T>C	uc002rru.2	-	9	1145	c.1108A>G	c.(1108-1110)ATT>GTT	p.I370V	THUMPD2_uc002rrv.2_RNA|THUMPD2_uc010ynt.1_Missense_Mutation_p.I261V	NM_025264	NP_079540	Q9BTF0	THUM2_HUMAN	THUMP domain containing 2	370							methyltransferase activity			skin(1)	1		all_hematologic(82;0.248)				GAAATAATAATATCAACACTT	0.279		NA											16	30					0	0	0	0
STON1-GTF2A1L	286749	broad.mit.edu	37	2	48848069	48848069	+	Missense_Mutation	SNP	A	A	G			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr2:48848069A>G	uc010yol.1	+	3	2260	c.2213A>G	c.(2212-2214)CAA>CGA	p.Q738R	STON1-GTF2A1L_uc002rwp.1_Missense_Mutation_p.Q738R|GTF2A1L_uc002rws.1_Missense_Mutation_p.Q34R|GTF2A1L_uc010yom.1_Intron|GTF2A1L_uc002rwt.2_Missense_Mutation_p.Q34R	NM_006873	NP_006864	B7ZL16	B7ZL16_HUMAN	stonin 1	738					endocytosis|intracellular protein transport|transcription initiation from RNA polymerase II promoter	clathrin adaptor complex|transcription factor TFIIA complex				ovary(3)|pancreas(1)|skin(1)	5		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.176)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)			ATAGAGGAACAAGTTTTAAAA	0.333		NA											18	31					0	0	0	0
NRXN1	9378	broad.mit.edu	37	2	51254950	51254950	+	Silent	SNP	G	G	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr2:51254950G>A	uc010fbq.2	-	2	1939	c.462C>T	c.(460-462)TTC>TTT	p.F154F	NRXN1_uc002rxe.3_Silent_p.F154F|NRXN1_uc002rxd.1_Silent_p.F154F	NM_001135659	NP_001129131	P58400	NRX1B_HUMAN	neurexin 1 isoform alpha2 precursor	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					angiogenesis|neuron cell-cell adhesion|neuronal signal transduction	cell surface|endocytic vesicle|integral to membrane|presynaptic membrane	cell adhesion molecule binding|receptor binding			ovary(2)	2		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.192)	Lung(47;0.0813)|LUSC - Lung squamous cell carcinoma(58;0.116)			GCCCCCCGACGAAAAGGCCGC	0.662		NA											5	21					0	0	0	0
CNRIP1	25927	broad.mit.edu	37	2	68521024	68521024	+	Silent	SNP	C	C	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr2:68521024C>A	uc002sek.3	-	3	1116	c.465G>T	c.(463-465)CTG>CTT	p.L155L	CNRIP1_uc002sej.3_Intron|CNRIP1_uc002sem.1_RNA|CNRIP1_uc002sel.3_RNA	NM_015463	NP_056278	Q96F85	CNRP1_HUMAN	cannabinoid receptor interacting protein 1	155							protein binding			liver(1)	1						TCACCCACATCAGACTGCGTG	0.473		NA											25	40					2.8e-10	3.52e-10	1	0
DYSF	8291	broad.mit.edu	37	2	71839829	71839829	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr2:71839829G>T	uc002sie.2	+	39	4602	c.4226G>T	c.(4225-4227)CGC>CTC	p.R1409L	DYSF_uc010feg.2_Missense_Mutation_p.R1440L|DYSF_uc010feh.2_Missense_Mutation_p.R1395L|DYSF_uc002sig.3_Missense_Mutation_p.R1395L|DYSF_uc010yqx.1_RNA|DYSF_uc010fee.2_Missense_Mutation_p.R1409L|DYSF_uc010fef.2_Missense_Mutation_p.R1426L|DYSF_uc010fei.2_Missense_Mutation_p.R1426L|DYSF_uc010fek.2_Missense_Mutation_p.R1427L|DYSF_uc010fej.2_Missense_Mutation_p.R1396L|DYSF_uc010fel.2_Missense_Mutation_p.R1396L|DYSF_uc010feo.2_Missense_Mutation_p.R1441L|DYSF_uc010fem.2_Missense_Mutation_p.R1410L|DYSF_uc010fen.2_Missense_Mutation_p.R1427L|DYSF_uc002sif.2_Missense_Mutation_p.R1410L|DYSF_uc010yqy.1_Missense_Mutation_p.R290L|DYSF_uc010yqz.1_Missense_Mutation_p.R149L	NM_003494	NP_003485	O75923	DYSF_HUMAN	dysferlin isoform 8	1409	Cytoplasmic (Potential).					cytoplasmic vesicle membrane|integral to membrane|sarcolemma	calcium-dependent phospholipid binding			ovary(3)|breast(2)|pancreas(1)|skin(1)	7						ATCGATAACCGCCAGTTTGGC	0.637		NA											23	52					2.42e-17	3.31e-17	1	0
REG3G	130120	broad.mit.edu	37	2	79254295	79254295	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr2:79254295C>A	uc002snw.2	+	4	416	c.331C>A	c.(331-333)CAG>AAG	p.Q111K	REG3G_uc002snx.2_Missense_Mutation_p.Q111K|REG3G_uc010ffu.2_Intron	NM_198448	NP_940850	Q6UW15	REG3G_HUMAN	regenerating islet-derived 3 gamma precursor	111	C-type lectin.				acute-phase response	extracellular region	sugar binding				0						TGACCCCACACAGGTGCGAGT	0.557		NA											33	67					3.76e-14	5e-14	1	0
LRRTM1	347730	broad.mit.edu	37	2	80529964	80529964	+	Silent	SNP	C	C	T			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr2:80529964C>T	uc002sok.1	-	2	1251	c.981G>A	c.(979-981)TCG>TCA	p.S327S	CTNNA2_uc010yse.1_Intron|CTNNA2_uc010ysf.1_Intron|CTNNA2_uc010ysg.1_Intron|CTNNA2_uc010ysh.1_Intron|CTNNA2_uc010ysi.1_5'Flank|LRRTM1_uc002soj.3_RNA	NM_178839	NP_849161	Q86UE6	LRRT1_HUMAN	leucine rich repeat transmembrane neuronal 1	327	LRRCT.|Lumenal (Potential).					axon|endoplasmic reticulum membrane|growth cone|integral to membrane				ovary(3)|upper_aerodigestive_tract(1)|skin(1)	5						TGTTGAGCCACGAGGCTAGGG	0.637		NA								HNSCC(69;0.2)			7	17					0	0	0	0
SMYD1	150572	broad.mit.edu	37	2	88405918	88405918	+	Silent	SNP	G	G	C			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr2:88405918G>C	uc002ssr.2	+	8	1058	c.1056G>C	c.(1054-1056)CGG>CGC	p.R352R	SMYD1_uc002ssq.1_Intron|SMYD1_uc002sss.2_Silent_p.R48R	NM_198274	NP_938015	Q8NB12	SMYD1_HUMAN	SET and MYND domain containing 1	352					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			ovary(2)|lung(1)|skin(1)	4						ACATGCTGCGGATGCTGAGCA	0.547		NA											22	41					0	0	0	0
CNGA3	1261	broad.mit.edu	37	2	98999860	98999860	+	Silent	SNP	C	C	T			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr2:98999860C>T	uc002syt.2	+	5	822	c.405C>T	c.(403-405)CCC>CCT	p.P135P	CNGA3_uc002syu.2_Intron|CNGA3_uc010fij.2_Silent_p.P139P	NM_001298	NP_001289	Q16281	CNGA3_HUMAN	cyclic nucleotide gated channel alpha 3 isoform	135					signal transduction|visual perception	integral to membrane	cGMP binding			ovary(5)|upper_aerodigestive_tract(1)	6						GCGCCTGGCCCCTGGCCAAAT	0.597		NA											9	39					0	0	0	0
C2orf55	343990	broad.mit.edu	37	2	99439551	99439551	+	Silent	SNP	G	G	T			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr2:99439551G>T	uc002szf.1	-	7	1479	c.1185C>A	c.(1183-1185)CCC>CCA	p.P395P		NM_207362	NP_997245	Q6NV74	CB055_HUMAN	hypothetical protein LOC343990	395	Pro-rich.										0						CGACGTCTTCGGGAGCACAGA	0.731		NA											8	11					0.00448238	0.00475768	1	0
IL1R1	3554	broad.mit.edu	37	2	102788275	102788275	+	Missense_Mutation	SNP	T	T	A	rs35308674	byFrequency	TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr2:102788275T>A	uc002tbq.2	+	8	1054	c.736T>A	c.(736-738)TTG>ATG	p.L246M	IL1R1_uc010fix.2_Missense_Mutation_p.L246M|IL1R1_uc002tbp.2_Missense_Mutation_p.L246M|IL1R1_uc002tbr.2_Missense_Mutation_p.L246M	NM_000877	NP_000868	P14778	IL1R1_HUMAN	interleukin 1 receptor, type I precursor	246	Ig-like C2-type 3.|Extracellular (Potential).				innate immune response	integral to plasma membrane	interleukin-1, Type I, activating receptor activity|platelet-derived growth factor receptor binding			skin(1)	1					Anakinra(DB00026)	CCAGATACAATTGATCTGTAA	0.294		NA											10	33					0	0	0	0
SLC5A7	60482	broad.mit.edu	37	2	108626897	108626897	+	Silent	SNP	T	T	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr2:108626897T>A	uc002tdv.2	+	9	1599	c.1323T>A	c.(1321-1323)TCT>TCA	p.S441S	SLC5A7_uc010ywm.1_Silent_p.S194S|SLC5A7_uc010fjj.2_Silent_p.S441S|SLC5A7_uc010ywn.1_Silent_p.S328S	NM_021815	NP_068587	Q9GZV3	SC5A7_HUMAN	solute carrier family 5 (choline transporter),	441	Helical; (Potential).				acetylcholine biosynthetic process|neurotransmitter secretion	integral to membrane|plasma membrane	choline:sodium symporter activity			ovary(2)|central_nervous_system(1)|skin(1)	4					Choline(DB00122)	GTTATGTTTCTGGCCTCTTCC	0.453		NA											16	49					0	0	0	0
PSD4	23550	broad.mit.edu	37	2	113955162	113955163	+	Missense_Mutation	DNP	GG	GG	TT			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr2:113955162_113955163GG>TT	uc002tjc.2	+	13	2591_2592	c.2408_2409GG>TT	c.(2407-2409)TGG>TTT	p.W803F	PSD4_uc002tjd.2_Missense_Mutation_p.W424F|PSD4_uc002tje.2_Missense_Mutation_p.W774F|PSD4_uc002tjf.2_Missense_Mutation_p.W424F|PSD4_uc002tjg.2_5'UTR|PSD4_uc010yxs.1_Missense_Mutation_p.W34F|PSD4_uc002tjh.2_5'Flank	NM_012455	NP_036587	Q8NDX1	PSD4_HUMAN	pleckstrin and Sec7 domain containing 4	803	PH.				regulation of ARF protein signal transduction	cytoplasm|plasma membrane	ARF guanyl-nucleotide exchange factor activity			ovary(2)	2						AAGCGTGGCTGGAAGATGTTCC	0.55		NA											6	25					0	0	0	0
THSD7B	80731	broad.mit.edu	37	2	138320906	138320906	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr2:138320906C>A	uc002tva.1	+	15	3167	c.3167C>A	c.(3166-3168)ACA>AAA	p.T1056K	THSD7B_uc010zbj.1_Intron	NM_001080427	NP_001073896			thrombospondin, type I, domain containing 7B											ovary(4)|central_nervous_system(2)|pancreas(1)	7				BRCA - Breast invasive adenocarcinoma(221;0.19)		GGAGGAGGAACACAATCTAGG	0.413		NA											14	30					2.32e-05	2.59e-05	1	0
LRP1B	53353	broad.mit.edu	37	2	141092122	141092122	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr2:141092122C>A	uc002tvj.1	-	79	13095	c.12123G>T	c.(12121-12123)ATG>ATT	p.M4041I		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	4041	Extracellular (Potential).|LDL-receptor class B 35.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		CAGTCCAGTACATCATCCTGA	0.383		NA								TSP Lung(27;0.18)			18	41					1.68e-08	2.04e-08	1	0
LRP1B	53353	broad.mit.edu	37	2	141108566	141108566	+	Missense_Mutation	SNP	T	T	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr2:141108566T>A	uc002tvj.1	-	77	12664	c.11692A>T	c.(11692-11694)ATC>TTC	p.I3898F		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	3898	Extracellular (Potential).				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		AAACCCAGGATATCAGTGTCA	0.284		NA								TSP Lung(27;0.18)			35	91					0	0	0	0
LRP1B	53353	broad.mit.edu	37	2	141208166	141208166	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr2:141208166C>G	uc002tvj.1	-	63	11000	c.10028G>C	c.(10027-10029)GGT>GCT	p.G3343A		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	3343	Extracellular (Potential).|LDL-receptor class A 21.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		AGATCCATCACCACAGTCATC	0.348		NA								TSP Lung(27;0.18)			19	65					0	0	0	0
NEB	4703	broad.mit.edu	37	2	152563504	152563504	+	Missense_Mutation	SNP	T	T	C			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr2:152563504T>C	uc010fnx.2	-	13	1234	c.1043A>G	c.(1042-1044)TAC>TGC	p.Y348C	NEB_uc010fny.1_Translation_Start_Site	NM_004543	NP_004534	P20929	NEBU_HUMAN	nebulin isoform 3	348	Nebulin 8.				muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			ovary(8)|large_intestine(5)|breast(3)|central_nervous_system(2)|skin(1)|pancreas(1)	20				BRCA - Breast invasive adenocarcinoma(221;0.219)		GTCTTCTTTGTATTTTACCTG	0.373		NA											5	11					0	0	0	0
FIGN	55137	broad.mit.edu	37	2	164467533	164467533	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr2:164467533G>T	uc002uck.1	-	3	1120	c.809C>A	c.(808-810)CCG>CAG	p.P270Q		NM_018086	NP_060556	Q5HY92	FIGN_HUMAN	fidgetin	270	Pro-rich.					nuclear matrix	ATP binding|nucleoside-triphosphatase activity			large_intestine(2)|ovary(1)|skin(1)	4						CGCTGAAGGCGGAGGCGGTGC	0.592		NA											19	35					7.45e-12	9.65e-12	1	0
SCN1A	6323	broad.mit.edu	37	2	166850763	166850763	+	Missense_Mutation	SNP	A	A	G			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr2:166850763A>G	uc010zcz.1	-	25	4730	c.4712T>C	c.(4711-4713)GTG>GCG	p.V1571A		NM_006920	NP_008851	P35498	SCN1A_HUMAN	sodium channel, voltage-gated, type I, alpha	1582	Helical; Name=S2 of repeat IV; (By similarity).|IV.					voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|skin(6)|large_intestine(1)	13					Lamotrigine(DB00555)|Levetiracetam(DB01202)|Phenacemide(DB01121)|Phenytoin(DB00252)|Topiramate(DB00273)|Zonisamide(DB00909)	AGTAAATAGCACAATGAACAC	0.378		NA											12	33					0	0	0	0
SCN9A	6335	broad.mit.edu	37	2	167056252	167056253	+	Missense_Mutation	DNP	GC	GC	TG			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr2:167056252_167056253GC>TG	uc010fpl.2	-	27	5204_5205	c.4863_4864GC>CA	c.(4861-4866)ACGCTG>ACCATG	p.L1622M	uc002udp.2_RNA	NM_002977	NP_002968	Q15858	SCN9A_HUMAN	sodium channel, voltage-gated, type IX, alpha	1633	IV.					voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|central_nervous_system(5)|skin(2)	13					Lamotrigine(DB00555)|Lidocaine(DB00281)	GCAAAGAGCAGCGTGCGGATCC	0.5		NA											54	109					0	0	0	0
XIRP2	129446	broad.mit.edu	37	2	168099600	168099600	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr2:168099600G>T	uc002udx.2	+	8	1716	c.1698G>T	c.(1696-1698)TGG>TGT	p.W566C	XIRP2_uc010fpn.2_Intron|XIRP2_uc010fpo.2_Intron|XIRP2_uc010fpp.2_Intron|XIRP2_uc002udy.2_Missense_Mutation_p.W391C|XIRP2_uc010fpq.2_Missense_Mutation_p.W344C|XIRP2_uc010fpr.2_Intron	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	391					actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14						ACTTGGAATGGGATGAAATTC	0.403		NA											13	25					1.5e-05	1.69e-05	1	0
AGPS	8540	broad.mit.edu	37	2	178301756	178301756	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr2:178301756G>T	uc002ull.2	+	5	658	c.611G>T	c.(610-612)CGA>CTA	p.R204L	AGPS_uc010zfb.1_Missense_Mutation_p.R114L	NM_003659	NP_003650	O00116	ADAS_HUMAN	alkyldihydroxyacetone phosphate synthase	204	FAD-binding PCMH-type.				ether lipid biosynthetic process	peroxisomal matrix|peroxisomal membrane|plasma membrane	alkylglycerone-phosphate synthase activity|flavin adenine dinucleotide binding|oxidoreductase activity	p.R204R(1)		ovary(2)|central_nervous_system(1)	3			OV - Ovarian serous cystadenocarcinoma(117;0.0018)|Epithelial(96;0.00919)|all cancers(119;0.0358)			ATGTTTGAGCGAATTCCTGAT	0.303		NA											30	72					3.67e-24	5.22e-24	1	0
TTN	7273	broad.mit.edu	37	2	179481873	179481873	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr2:179481873C>A	uc010zfg.1	-	204	40369	c.40145G>T	c.(40144-40146)GGT>GTT	p.G13382V	TTN_uc010zfh.1_Missense_Mutation_p.G7077V|TTN_uc010zfi.1_Missense_Mutation_p.G7010V|TTN_uc010zfj.1_Missense_Mutation_p.G6885V	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	14309							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GGTGAGAGGACCAAGAATTTC	0.368		NA											7	18					1.13e-05	1.28e-05	1	0
TTN	7273	broad.mit.edu	37	2	179577472	179577472	+	Missense_Mutation	SNP	T	T	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr2:179577472T>A	uc010zfg.1	-	91	23772	c.23548A>T	c.(23548-23550)AGC>TGC	p.S7850C	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.S4511C	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	8777							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GCTTCATTGCTAACTATGCAA	0.393		NA											25	69					0	0	0	0
CWC22	57703	broad.mit.edu	37	2	180835757	180835757	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr2:180835757C>G	uc010frh.1	-	9	1151	c.851G>C	c.(850-852)AGA>ACA	p.R284T	CWC22_uc002unp.2_Missense_Mutation_p.R284T	NM_020943	NP_065994	Q9HCG8	CWC22_HUMAN	CWC22 spliceosome-associated protein homolog	284	MIF4G.					catalytic step 2 spliceosome	protein binding|RNA binding				0						ATCTGTTGGTCTTTCCAGGAG	0.353		NA											16	22					0	0	0	0
CWC22	57703	broad.mit.edu	37	2	180851515	180851515	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr2:180851515C>G	uc010frh.1	-	4	413	c.113G>C	c.(112-114)CGA>CCA	p.R38P	CWC22_uc002unp.2_Missense_Mutation_p.R38P	NM_020943	NP_065994	Q9HCG8	CWC22_HUMAN	CWC22 spliceosome-associated protein homolog	38	Arg-rich.					catalytic step 2 spliceosome	protein binding|RNA binding				0						CCGGGGGGATCGTTCTTGTTC	0.343		NA											18	17					0	0	0	0
SLC39A10	57181	broad.mit.edu	37	2	196581405	196581405	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr2:196581405G>A	uc002utg.3	+	7	1955	c.1741G>A	c.(1741-1743)GAA>AAA	p.E581K	SLC39A10_uc002uth.3_Missense_Mutation_p.E581K|SLC39A10_uc010zgp.1_Missense_Mutation_p.E131K	NM_001127257	NP_001120729	Q9ULF5	S39AA_HUMAN	solute carrier family 39 (zinc transporter),	581					zinc ion transport	integral to membrane	metal ion transmembrane transporter activity			pancreas(1)|skin(1)	2			OV - Ovarian serous cystadenocarcinoma(117;0.221)			TAATGAAACTGAACTGACAGA	0.348		NA											20	33					0	0	0	0
DNAH7	56171	broad.mit.edu	37	2	196659141	196659142	+	Missense_Mutation	DNP	CC	CC	TA			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr2:196659141_196659142CC>TA	uc002utj.3	-	57	10737_10738	c.10636_10637GG>TA	c.(10636-10638)GGT>TAT	p.G3546Y	DNAH7_uc002uti.3_Missense_Mutation_p.G29Y	NM_018897	NP_061720	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	3546	AAA 6 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			skin(10)|ovary(2)	12						AGCCCGTAAACCTTTTGGTGCT	0.441		NA											35	83					0	0	0	0
DNAH7	56171	broad.mit.edu	37	2	196674504	196674504	+	Missense_Mutation	SNP	A	A	C			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr2:196674504A>C	uc002utj.3	-	52	9954	c.9853T>G	c.(9853-9855)TGT>GGT	p.C3285G		NM_018897	NP_061720	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	3285					ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			skin(10)|ovary(2)	12						ATGGTTAGACAAAAGGAAAAG	0.368		NA											19	31					0	0	0	0
HECW2	57520	broad.mit.edu	37	2	197092955	197092955	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr2:197092955C>A	uc002utm.1	-	22	3971	c.3788G>T	c.(3787-3789)AGA>ATA	p.R1263I	HECW2_uc002utl.1_Missense_Mutation_p.R907I	NM_020760	NP_065811	Q9P2P5	HECW2_HUMAN	HECT, C2 and WW domain containing E3 ubiquitin	1263	HECT.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm	ubiquitin-protein ligase activity			skin(5)|ovary(5)|lung(4)|pancreas(2)|central_nervous_system(1)|kidney(1)	18						GAAAAACTCTCTAGAAGGCCC	0.363		NA											20	29					8.1e-08	9.71e-08	1	0
FZD7	8324	broad.mit.edu	37	2	202900651	202900651	+	Silent	SNP	G	G	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr2:202900651G>A	uc002uyw.1	+	1	1342	c.1281G>A	c.(1279-1281)GCG>GCA	p.A427A		NM_003507	NP_003498	O75084	FZD7_HUMAN	frizzled 7 precursor	427	Helical; Name=5; (Potential).				axonogenesis|brain development|canonical Wnt receptor signaling pathway|cellular response to retinoic acid|G-protein signaling, coupled to cGMP nucleotide second messenger|gonad development|mesenchymal to epithelial transition|negative regulation of cell-substrate adhesion|negative regulation of ectodermal cell fate specification|positive regulation of epithelial cell proliferation involved in wound healing|positive regulation of phosphorylation|positive regulation of transcription, DNA-dependent|regulation of catenin import into nucleus|vasculature development|Wnt receptor signaling pathway, calcium modulating pathway	apical part of cell|cytoplasm|integral to membrane|neuron projection membrane	G-protein coupled receptor activity|PDZ domain binding|Wnt receptor activity|Wnt-protein binding			skin(2)|ovary(1)|breast(1)	4						TCGTGCTGGCGCCTCTGTTCG	0.617		NA									OREG0015146	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	78					0	0	0	0
FZD5	7855	broad.mit.edu	37	2	208632914	208632914	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr2:208632914C>A	uc002vcj.2	-	2	960	c.550G>T	c.(550-552)GCT>TCT	p.A184S		NM_003468	NP_003459	Q13467	FZD5_HUMAN	frizzled 5 precursor	184	Extracellular (Potential).				angiogenesis|anterior/posterior axis specification, embryo|axonogenesis|brain development|canonical Wnt receptor signaling pathway|cellular response to molecule of bacterial origin|embryonic camera-type eye development|gonad development|labyrinthine layer blood vessel development|positive regulation of interferon-gamma production|positive regulation of transcription from RNA polymerase II promoter|post-embryonic camera-type eye development|Spemann organizer formation|T cell differentiation in thymus|Wnt receptor signaling pathway involved in dorsal/ventral axis specification	cell projection|cell surface|Golgi membrane|integral to membrane|plasma membrane	G-protein coupled receptor activity|PDZ domain binding|protein kinase binding|Wnt-protein binding			ovary(2)|lung(1)	3				LUSC - Lung squamous cell carcinoma(261;0.0703)|Epithelial(149;0.13)|Lung(261;0.134)		GGGCCCCCAGCGGGGCATTCG	0.711		NA											12	11					4.37e-10	5.47e-10	1	0
CUL3	8452	broad.mit.edu	37	2	225371641	225371641	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr2:225371641C>G	uc002vny.2	-	7	1347	c.963G>C	c.(961-963)TTG>TTC	p.L321F	CUL3_uc010zls.1_Missense_Mutation_p.L255F|CUL3_uc010fwy.1_Missense_Mutation_p.L327F	NM_003590	NP_003581	Q13618	CUL3_HUMAN	cullin 3	321					cell cycle arrest|cell migration|cyclin catabolic process|cytokinesis|G1/S transition of mitotic cell cycle|induction of apoptosis by intracellular signals|mitotic anaphase|negative regulation of Rho protein signal transduction|positive regulation of cell proliferation|protein ubiquitination|stress fiber assembly	Cul3-RING ubiquitin ligase complex|Golgi apparatus|nucleus|polar microtubule	ubiquitin protein ligase binding			upper_aerodigestive_tract(1)|ovary(1)|liver(1)|kidney(1)	4		all_lung(227;0.00877)|Lung NSC(271;0.011)|Renal(207;0.0112)|all_hematologic(139;0.138)		Epithelial(121;1.58e-11)|all cancers(144;1.43e-08)|Lung(261;0.00863)|LUSC - Lung squamous cell carcinoma(224;0.00902)		CTTGCTCCCTCAAATAGGAAC	0.378		NA											26	36					0	0	0	0
SLC19A3	80704	broad.mit.edu	37	2	228563910	228563910	+	Missense_Mutation	SNP	A	A	T			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr2:228563910A>T	uc002vpi.2	-	3	610	c.521T>A	c.(520-522)GTC>GAC	p.V174D	SLC19A3_uc002vpj.2_RNA|SLC19A3_uc010zlv.1_Missense_Mutation_p.V170D	NM_025243	NP_079519	Q9BZV2	S19A3_HUMAN	solute carrier family 19, member 3	174	Helical; (Potential).				thiamine-containing compound metabolic process	integral to membrane|plasma membrane	folic acid binding|reduced folate carrier activity|thiamine uptake transmembrane transporter activity			ovary(2)	2		Renal(207;0.0112)|all_lung(227;0.0335)|Lung NSC(271;0.142)|all_hematologic(139;0.21)|Esophageal squamous(248;0.236)		Epithelial(121;1.58e-10)|all cancers(144;8.55e-08)|Lung(261;0.00948)|LUSC - Lung squamous cell carcinoma(224;0.0125)	L-Cysteine(DB00151)	CAAGGATATGACGTTGAGGTA	0.507		NA											27	85					0	0	0	0
SPHKAP	80309	broad.mit.edu	37	2	228890142	228890142	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr2:228890142C>T	uc002vpq.2	-	5	456	c.409G>A	c.(409-411)GGA>AGA	p.G137R	SPHKAP_uc002vpp.2_Missense_Mutation_p.G137R|SPHKAP_uc010zlx.1_Missense_Mutation_p.G137R	NM_001142644	NP_001136116	Q2M3C7	SPKAP_HUMAN	sphingosine kinase type 1-interacting protein	137						cytoplasm	protein binding			skin(5)|ovary(4)|lung(1)	10		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;8.17e-11)|all cancers(144;7.92e-08)|Lung(261;0.0168)|LUSC - Lung squamous cell carcinoma(224;0.0232)		TGGAGATTTCCAGAGGCTAAC	0.378		NA											19	60					0	0	0	0
TRIP12	9320	broad.mit.edu	37	2	230652349	230652349	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr2:230652349G>A	uc002vpw.1	-	32	4751	c.4642C>T	c.(4642-4644)CAA>TAA	p.Q1548*	TRIP12_uc002vpx.1_Nonsense_Mutation_p.Q1596*|TRIP12_uc002vpy.1_Nonsense_Mutation_p.Q1278*	NM_004238	NP_004229	Q14669	TRIPC_HUMAN	thyroid hormone receptor interactor 12	1548	K-box.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	proteasome complex	thyroid hormone receptor binding|ubiquitin-protein ligase activity			ovary(4)|lung(2)|breast(1)|central_nervous_system(1)|skin(1)	9		Renal(207;0.025)|all_hematologic(139;0.122)|all_lung(227;0.126)|Acute lymphoblastic leukemia(138;0.164)		Epithelial(121;4.76e-13)|all cancers(144;4.34e-10)|LUSC - Lung squamous cell carcinoma(224;0.00864)|Lung(119;0.0116)		AAAAGCATTTGCCGGGTATCA	0.353		NA											14	31					0	0	0	0
COL6A3	1293	broad.mit.edu	37	2	238277511	238277511	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr2:238277511G>T	uc002vwl.2	-	10	4880	c.4595C>A	c.(4594-4596)GCG>GAG	p.A1532E	COL6A3_uc002vwo.2_Missense_Mutation_p.A1326E|COL6A3_uc010znj.1_Missense_Mutation_p.A925E	NM_004369	NP_004360	P12111	CO6A3_HUMAN	alpha 3 type VI collagen isoform 1 precursor	1532	VWFA 8.|Nonhelical region.				axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			ovary(8)|central_nervous_system(6)|skin(2)|upper_aerodigestive_tract(1)|pancreas(1)	18		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		GCGACTCCCCGCAGACTTAAC	0.597		NA											34	46					3.9e-15	5.24e-15	1	0
GAL3ST2	64090	broad.mit.edu	37	2	242741244	242741244	+	Silent	SNP	C	C	T			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr2:242741244C>T	uc002wcj.1	+	3	299	c.168C>T	c.(166-168)TTC>TTT	p.F56F		NM_022134	NP_071417	Q9H3Q3	G3ST2_HUMAN	galactose-3-O-sulfotransferase 2	56	Lumenal (Potential).				biosynthetic process	Golgi cisterna membrane|integral to membrane	galactosylceramide sulfotransferase activity				0		all_cancers(19;1.09e-40)|all_epithelial(40;2.03e-18)|Breast(86;1.53e-05)|all_lung(227;0.00338)|Renal(207;0.00502)|Ovarian(221;0.00716)|Lung NSC(271;0.012)|Esophageal squamous(248;0.129)|Melanoma(123;0.144)|all_hematologic(139;0.158)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;4.59e-33)|all cancers(36;9.89e-31)|OV - Ovarian serous cystadenocarcinoma(60;7.89e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;1.63e-06)|Lung(119;0.000152)|LUSC - Lung squamous cell carcinoma(224;0.00154)|Colorectal(34;0.0129)|COAD - Colon adenocarcinoma(134;0.0833)		ACATCATGTTCCTGAAGACGC	0.662		NA											18	33					0	0	0	0
C20orf27	54976	broad.mit.edu	37	20	3735131	3735131	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr20:3735131C>G	uc002wji.1	-	5	566	c.337G>C	c.(337-339)GAG>CAG	p.E113Q	C20orf27_uc002wjf.1_3'UTR|C20orf27_uc002wjh.1_Missense_Mutation_p.E138Q	NM_001039140	NP_001034229	Q9GZN8	CT027_HUMAN	hypothetical protein LOC54976	113											0						AGGACGCCCTCTTTGTGCGCC	0.632		NA											24	53					0	0	0	0
PAK7	57144	broad.mit.edu	37	20	9561116	9561116	+	Silent	SNP	G	G	T			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr20:9561116G>T	uc002wnl.2	-	5	1211	c.666C>A	c.(664-666)GCC>GCA	p.A222A	PAK7_uc002wnk.2_Silent_p.A222A|PAK7_uc002wnj.2_Silent_p.A222A|PAK7_uc010gby.1_Silent_p.A222A	NM_020341	NP_065074	Q9P286	PAK7_HUMAN	p21-activated kinase 7	222	Linker.						ATP binding|protein binding|protein serine/threonine kinase activity			lung(11)|skin(5)|central_nervous_system(3)|ovary(2)|large_intestine(1)|stomach(1)	23			COAD - Colon adenocarcinoma(9;0.194)			AGCTACTCGAGGCTCTCTGAT	0.488		NA											20	43					2.39e-15	3.23e-15	1	0
C20orf160	140706	broad.mit.edu	37	20	30610545	30610545	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr20:30610545G>T	uc002wxf.2	+	6	1029	c.1016G>T	c.(1015-1017)CGG>CTG	p.R339L	C20orf160_uc002wxg.2_5'UTR	NM_080625	NP_542192	Q9NUG4	CT160_HUMAN	hypothetical protein LOC140706	339										central_nervous_system(3)|ovary(1)	4						TGTGTGGACCGGGCTGGCTAC	0.587		NA											15	46					2.62e-11	3.36e-11	1	0
C20orf114	92747	broad.mit.edu	37	20	31877739	31877739	+	Silent	SNP	G	G	T			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr20:31877739G>T	uc002wyw.1	+	4	467	c.306G>T	c.(304-306)TCG>TCT	p.S102S	C20orf114_uc010gej.1_Silent_p.S102S	NM_033197	NP_149974	Q8TDL5	LPLC1_HUMAN	LPLUNC1 protein precursor	102						extracellular space	lipid binding			central_nervous_system(2)|skin(2)	4						TGAAGCCCTCGGCCAATGACC	0.542		NA											17	47					9.17e-09	1.12e-08	1	0
BPI	671	broad.mit.edu	37	20	36952317	36952317	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr20:36952317C>T	uc002xib.2	+	8	876	c.814C>T	c.(814-816)CCA>TCA	p.P272S		NM_001725	NP_001716	P17213	BPI_HUMAN	bactericidal/permeability-increasing protein	272					defense response to bacterium|negative regulation of interleukin-6 production|negative regulation of interleukin-8 production|negative regulation of macrophage activation|negative regulation of tumor necrosis factor production	extracellular region|integral to plasma membrane	lipid binding|lipopolysaccharide binding			ovary(4)	4		Myeloproliferative disorder(115;0.00878)				TCCCTTTGCTCCACCAGTGAT	0.522		NA											23	45					0	0	0	0
ACTR5	79913	broad.mit.edu	37	20	37378668	37378668	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr20:37378668C>T	uc002xjd.2	+	2	416	c.391C>T	c.(391-393)CCC>TCC	p.P131S		NM_024855	NP_079131	Q9H9F9	ARP5_HUMAN	ARP5 actin-related protein 5 homolog	131					DNA recombination|double-strand break repair|regulation of transcription, DNA-dependent|transcription, DNA-dependent|UV-damage excision repair	cytoplasm|Ino80 complex	ATP binding|protein binding				0		Myeloproliferative disorder(115;0.00878)				TGTTGATCATCCCATAGTTTT	0.413		NA											23	55					0	0	0	0
ZNF831	128611	broad.mit.edu	37	20	57769304	57769304	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr20:57769304G>T	uc002yan.2	+	1	3230	c.3230G>T	c.(3229-3231)CGC>CTC	p.R1077L		NM_178457	NP_848552	Q5JPB2	ZN831_HUMAN	zinc finger protein 831	1077						intracellular	nucleic acid binding|zinc ion binding	p.R1077C(1)		skin(13)|ovary(1)	14	all_lung(29;0.0085)					CGTATCCATCGCCTCTGCATG	0.637		NA											10	32					1.77e-08	2.14e-08	1	0
TAF4	6874	broad.mit.edu	37	20	60581806	60581806	+	Silent	SNP	T	T	C			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr20:60581806T>C	uc002ybs.2	-	7	1983	c.1983A>G	c.(1981-1983)TTA>TTG	p.L661L		NM_003185	NP_003176	O00268	TAF4_HUMAN	TBP-associated factor 4	661	TAFH.				interspecies interaction between organisms|positive regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	cytoplasm|MLL1 complex|transcription factor TFIID complex|transcription factor TFTC complex	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			ovary(2)|pancreas(1)	3	Breast(26;1e-08)		BRCA - Breast invasive adenocarcinoma(19;3.1e-07)			TCAAGGCGGGTAAGCTCCTCT	0.587		NA											16	27					0	0	0	0
ZNF512B	57473	broad.mit.edu	37	20	62597874	62597874	+	Silent	SNP	G	G	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr20:62597874G>A	uc002yhl.1	-	5	708	c.654C>T	c.(652-654)GTC>GTT	p.V218V		NM_020713	NP_065764	Q96KM6	Z512B_HUMAN	zinc finger protein 512B	218					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_cancers(38;2.14e-11)|all_epithelial(29;3.41e-13)|Lung NSC(23;3.41e-09)|all_lung(23;1.06e-08)					TGGGTCTGCCGACCGAGACTG	0.597		NA											65	165					0	0	0	0
KRTAP6-2	337967	broad.mit.edu	37	21	31971084	31971084	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr21:31971084C>G	uc011adc.1	-	1	110	c.110G>C	c.(109-111)TGC>TCC	p.C37S	KRTAP22-1_uc011add.1_5'Flank	NM_181604	NP_853635	Q3LI66	KRA62_HUMAN	keratin associated protein 6-2	37						intermediate filament					0						ATAGCCACAGCAGGAGCTATA	0.562		NA											14	39					0	0	0	0
SYNJ1	8867	broad.mit.edu	37	21	34018775	34018775	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr21:34018775C>A	uc002yqh.2	-	24	3292	c.3292G>T	c.(3292-3294)GGT>TGT	p.G1098C	SYNJ1_uc011ads.1_Missense_Mutation_p.G1054C|SYNJ1_uc002yqf.2_Missense_Mutation_p.G1059C|SYNJ1_uc002yqg.2_Missense_Mutation_p.G1054C|SYNJ1_uc002yqi.2_Missense_Mutation_p.G1098C	NM_003895	NP_003886	O43426	SYNJ1_HUMAN	synaptojanin 1 isoform a	1059	Pro-rich.						inositol-polyphosphate 5-phosphatase activity|nucleotide binding|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|RNA binding			ovary(4)|skin(1)	5						GGTACAGGACCCTCTGATATT	0.517		NA											61	99					3.96e-38	5.78e-38	1	0
CLIC6	54102	broad.mit.edu	37	21	36042977	36042977	+	Silent	SNP	G	G	C			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr21:36042977G>C	uc010gmt.1	+	1	1290	c.1290G>C	c.(1288-1290)GCG>GCC	p.A430A	CLIC6_uc002yuf.1_Silent_p.A430A	NM_053277	NP_444507	Q96NY7	CLIC6_HUMAN	chloride intracellular channel 6	430						chloride channel complex|cytoplasm|plasma membrane	voltage-gated chloride channel activity			ovary(1)|central_nervous_system(1)	2						GCGAGGCCGCGCGCGTGAACG	0.741		NA											5	4					0	0	0	0
DSCAM	1826	broad.mit.edu	37	21	41505903	41505903	+	Missense_Mutation	SNP	T	T	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr21:41505903T>A	uc002yyq.1	-	19	3892	c.3440A>T	c.(3439-3441)CAG>CTG	p.Q1147L	DSCAM_uc002yyr.1_RNA	NM_001389	NP_001380	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule isoform	1147	Extracellular (Potential).|Fibronectin type-III 3.				cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			ovary(6)|skin(4)|upper_aerodigestive_tract(1)	11		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				CAGTGAAGGCTGTGTGGTGGT	0.532		NA											18	38					0	0	0	0
MCM3AP	8888	broad.mit.edu	37	21	47704494	47704494	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr21:47704494C>G	uc002zir.1	-	1	743	c.707G>C	c.(706-708)AGA>ACA	p.R236T	C21orf57_uc002zit.1_5'Flank|C21orf57_uc002ziu.1_5'Flank|C21orf57_uc002ziv.2_5'Flank|C21orf57_uc002ziw.2_5'Flank|C21orf57_uc002zix.2_5'Flank|C21orf57_uc010gqh.2_5'Flank|C21orf57_uc002ziy.2_5'Flank	NM_003906	NP_003897	O60318	MCM3A_HUMAN	minichromosome maintenance complex component 3	236					DNA replication|protein import into nucleus	cytosol|nucleus	DNA binding|nucleotide binding			large_intestine(2)|lung(1)|ovary(1)|skin(1)	5	Breast(49;0.112)					CTTAGGTCCTCTCTTCTCTTC	0.393		NA											22	67					0	0	0	0
MCM3AP	8888	broad.mit.edu	37	21	47704507	47704507	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr21:47704507C>G	uc002zir.1	-	1	730	c.694G>C	c.(694-696)GAG>CAG	p.E232Q	C21orf57_uc002zit.1_5'Flank|C21orf57_uc002ziu.1_5'Flank|C21orf57_uc002ziv.2_5'Flank|C21orf57_uc002ziw.2_5'Flank|C21orf57_uc002zix.2_5'Flank|C21orf57_uc010gqh.2_5'Flank|C21orf57_uc002ziy.2_5'Flank	NM_003906	NP_003897	O60318	MCM3A_HUMAN	minichromosome maintenance complex component 3	232					DNA replication|protein import into nucleus	cytosol|nucleus	DNA binding|nucleotide binding			large_intestine(2)|lung(1)|ovary(1)|skin(1)	5	Breast(49;0.112)					TTCTCTTCCTCTACATTTTGG	0.388		NA											21	61					0	0	0	0
ZNF280B	140883	broad.mit.edu	37	22	22843555	22843555	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr22:22843555C>G	uc002zwc.1	-	4	945	c.169G>C	c.(169-171)GTT>CTT	p.V57L	LOC96610_uc011aim.1_Intron	NM_080764	NP_542942	Q86YH2	Z280B_HUMAN	zinc finger protein 280B	57					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2	all_hematologic(9;0.0135)|Acute lymphoblastic leukemia(84;0.17)	all_hematologic(6;1.74e-30)|Acute lymphoblastic leukemia(6;7.75e-22)		READ - Rectum adenocarcinoma(21;0.145)		ATGTTTGAAACGACTGGTTTT	0.408		NA											30	56					0	0	0	0
GNAZ	2781	broad.mit.edu	37	22	23465617	23465617	+	Silent	SNP	G	G	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr22:23465617G>A	uc002zwu.1	+	3	1604	c.1067G>A	c.(1066-1068)TGA>TAA	p.*356*	RTDR1_uc002zwt.2_Intron	NM_002073	NP_002064	P19086	GNAZ_HUMAN	guanine nucleotide binding protein, alpha z	356						endoplasmic reticulum|heterotrimeric G-protein complex|nuclear envelope	G-protein beta/gamma-subunit complex binding|GTP binding|GTPase activity|guanyl-nucleotide exchange factor activity|metabotropic serotonin receptor binding|receptor signaling protein activity			kidney(1)|skin(1)	2	all_hematologic(9;0.0197)|Acute lymphoblastic leukemia(84;0.181)			READ - Rectum adenocarcinoma(21;0.166)		GGCCTTTGCTGAGGAGCTGGG	0.587		NA											6	4					0	0	0	0
SUSD2	56241	broad.mit.edu	37	22	24584279	24584279	+	Missense_Mutation	SNP	C	C	A	rs150371467		TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr22:24584279C>A	uc002zzn.1	+	14	2472	c.2428C>A	c.(2428-2430)CGC>AGC	p.R810S		NM_019601	NP_062547	Q9UGT4	SUSD2_HUMAN	sushi domain containing 2 precursor	810	Cytoplasmic (Potential).				immune response	integral to membrane	polysaccharide binding|protein binding|scavenger receptor activity			skin(1)	1						GCTGCTGCGCCGCAGGAAGGG	0.657		NA											8	20					0.00621372	0.00653871	1	0
GGT5	2687	broad.mit.edu	37	22	24622662	24622662	+	Silent	SNP	C	C	G			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr22:24622662C>G	uc002zzo.3	-	7	1392	c.975G>C	c.(973-975)ACG>ACC	p.T325T	GGT5_uc002zzp.3_Silent_p.T325T|GGT5_uc002zzr.3_Silent_p.T293T|GGT5_uc002zzq.3_Silent_p.T293T|GGT5_uc011ajm.1_Silent_p.T248T|GGT5_uc011ajn.1_RNA	NM_004121	NP_004112	P36269	GGT5_HUMAN	gamma-glutamyltransferase 5 isoform b	325	Extracellular (Potential).				glutathione biosynthetic process|hormone biosynthetic process|leukotriene biosynthetic process|prostanoid metabolic process	integral to membrane|plasma membrane	acyltransferase activity|gamma-glutamyltransferase activity			ovary(2)|skin(1)	3						CAAACTTGAGCGTCTCTACAA	0.612		NA											21	61					0	0	0	0
CRYBB1	1414	broad.mit.edu	37	22	26995525	26995525	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr22:26995525G>T	uc003acy.1	-	6	758	c.688C>A	c.(688-690)CGT>AGT	p.R230S		NM_001887	NP_001878	P53674	CRBB1_HUMAN	crystallin, beta B1	230	Beta/gamma crystallin 'Greek key' 4.				visual perception		structural constituent of eye lens			ovary(1)	1						CGCAGGCGACGCAGGGACTGC	0.627		NA											21	45					8.1e-08	9.71e-08	1	0
RFPL1	5988	broad.mit.edu	37	22	29835041	29835041	+	Silent	SNP	G	G	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr22:29835041G>A	uc003afn.2	+	1	470	c.261G>A	c.(259-261)AAG>AAA	p.K87K	RFPL1S_uc003afm.1_RNA	NM_021026	NP_066306	O75677	RFPL1_HUMAN	ret finger protein-like 1	87							zinc ion binding				0						TCTCTCAGAAGAACAAAATCA	0.517		NA											28	70					0	0	0	0
DUSP18	150290	broad.mit.edu	37	22	31059931	31059931	+	Silent	SNP	G	G	C			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr22:31059931G>C	uc003aiu.2	-	2	561	c.60C>G	c.(58-60)CTC>CTG	p.L20L	SLC35E4_uc003ait.2_Intron|DUSP18_uc010gwa.1_RNA|DUSP18_uc003aiw.1_Silent_p.L20L	NM_152511	NP_689724	Q8NEJ0	DUS18_HUMAN	dual specificity phosphatase 18	20						cytoplasm|nucleus	MAP kinase tyrosine/serine/threonine phosphatase activity|protein tyrosine phosphatase activity				0						TTATCTGCGAGAGGCCGCTGA	0.552		NA											15	40					0	0	0	0
GTSE1	51512	broad.mit.edu	37	22	46722418	46722418	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr22:46722418C>T	uc011aqy.1	+	9	1803	c.1591C>T	c.(1591-1593)CCC>TCC	p.P531S	GTSE1_uc011aqz.1_Missense_Mutation_p.P378S|GTSE1_uc003bhl.1_Missense_Mutation_p.P156S|GTSE1_uc003bhm.1_Missense_Mutation_p.P156S|GTSE1_uc003bhn.2_5'Flank	NM_016426	NP_057510	Q9NYZ3	GTSE1_HUMAN	G-2 and S-phase expressed 1	512					DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G2 phase of mitotic cell cycle|microtubule-based process	cytoplasmic microtubule				ovary(1)	1		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00462)		GTCAGCCTTGCCCACACCCGC	0.652		NA											21	37					0	0	0	0
PLCL2	23228	broad.mit.edu	37	3	17052928	17052928	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr3:17052928G>C	uc011awc.1	+	5	2171	c.2066G>C	c.(2065-2067)TGC>TCC	p.C689S	PLCL2_uc011awd.1_Missense_Mutation_p.C571S	NM_001144382	NP_001137854	Q9UPR0	PLCL2_HUMAN	phospholipase C-like 2 isoform 1	697	PI-PLC Y-box.				intracellular signal transduction|lipid metabolic process	cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			skin(2)|ovary(1)|lung(1)	4						AAATGTGGTTGCCAAATTGTA	0.418		NA											29	31					0	0	0	0
LYZL4	131375	broad.mit.edu	37	3	42445602	42445602	+	Missense_Mutation	SNP	T	T	C			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr3:42445602T>C	uc003cle.2	-	4	556	c.307A>G	c.(307-309)AAT>GAT	p.N103D		NM_144634	NP_653235	Q96KX0	LYZL4_HUMAN	lysozyme-like 4 precursor	103					cell wall macromolecule catabolic process	extracellular region	lysozyme activity			central_nervous_system(1)	1				KIRC - Kidney renal clear cell carcinoma(284;0.222)		TTCTCTAAATTAGGATTCAGT	0.388		NA											18	15					0	0	0	0
CCBP2	1238	broad.mit.edu	37	3	42906247	42906247	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr3:42906247C>G	uc003cme.2	+	3	432	c.253C>G	c.(253-255)CTG>GTG	p.L85V	CCBP2_uc003cmd.1_Missense_Mutation_p.L85V|CCBP2_uc003cmf.2_Missense_Mutation_p.L85V|CCBP2_uc003cmg.2_Intron|CYP8B1_uc010hif.2_Intron	NM_001296	NP_001287	O00590	CCBP2_HUMAN	chemokine binding protein 2	85	Cytoplasmic (Potential).				chemotaxis|immune response|multicellular organismal development	integral to plasma membrane	C-X-C chemokine receptor activity			lung(4)|skin(1)	5				KIRC - Kidney renal clear cell carcinoma(284;0.241)		TGAGATCTATCTGCTGAATCT	0.537		NA											53	51					0	0	0	0
C3orf23	285343	broad.mit.edu	37	3	44449031	44449031	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr3:44449031G>C	uc010him.2	+	11	1593	c.1348G>C	c.(1348-1350)GTG>CTG	p.V450L	C3orf23_uc003cnd.3_Missense_Mutation_p.V450L|C3orf23_uc003cne.3_Missense_Mutation_p.V306L	NM_173826	NP_776187	Q8N3R3	CC023_HUMAN	hypothetical protein LOC285343 isoform 1	450						mitochondrion				upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3				KIRC - Kidney renal clear cell carcinoma(197;0.0468)|Kidney(197;0.0585)		TATACAAATGGTGGATTGTTG	0.358		NA											19	28					0	0	0	0
ZNF660	285349	broad.mit.edu	37	3	44636619	44636619	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr3:44636619C>T	uc003cnl.1	+	3	1267	c.934C>T	c.(934-936)CGG>TGG	p.R312W		NM_173658	NP_775929	Q6AZW8	ZN660_HUMAN	zinc finger protein 660	312	C2H2-type 10.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				KIRC - Kidney renal clear cell carcinoma(197;0.0468)|Kidney(197;0.0585)		GAAAGCCTATCGGTATAGTTC	0.408		NA											14	29					0	0	0	0
TGM4	7047	broad.mit.edu	37	3	44945437	44945437	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr3:44945437G>A	uc003coc.3	+	9	1106	c.1033G>A	c.(1033-1035)GGC>AGC	p.G345S		NM_003241	NP_003232	P49221	TGM4_HUMAN	transglutaminase 4 (prostate)	345					peptide cross-linking|protein polyamination		acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.00963)|KIRC - Kidney renal clear cell carcinoma(197;0.0546)|Kidney(197;0.0686)	L-Glutamine(DB00130)	GGGCTACGACGGCTGGCAGGC	0.652		NA											35	46					0	0	0	0
USP19	10869	broad.mit.edu	37	3	49149744	49149744	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr3:49149744C>A	uc003cwd.1	-	18	2590	c.2429G>T	c.(2428-2430)CGG>CTG	p.R810L	USP19_uc003cwa.2_Missense_Mutation_p.R618L|USP19_uc003cvz.3_Missense_Mutation_p.R913L|USP19_uc011bcg.1_Missense_Mutation_p.R901L|USP19_uc003cwb.2_Intron|USP19_uc003cwc.1_Missense_Mutation_p.R568L|USP19_uc011bch.1_Missense_Mutation_p.R911L	NM_006677	NP_006668	O94966	UBP19_HUMAN	ubiquitin thioesterase 19	810	Cytoplasmic (Potential).|MYND-type.				ER-associated protein catabolic process|positive regulation of cell cycle process|protein deubiquitination|regulation of protein stability|response to endoplasmic reticulum stress|skeletal muscle atrophy	endoplasmic reticulum membrane|integral to membrane	ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			ovary(4)|breast(2)|lung(1)	7				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00219)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		ACGGTAGCACCGGGTACAGCG	0.617		NA											4	6					1.24e-05	1.4e-05	1	0
FEZF2	55079	broad.mit.edu	37	3	62358002	62358002	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr3:62358002G>C	uc003dlh.2	-	1	749	c.542C>G	c.(541-543)CCG>CGG	p.P181R	FEZF2_uc003dli.2_Missense_Mutation_p.P181R	NM_018008	NP_060478	Q8TBJ5	FEZF2_HUMAN	FEZ family zinc finger 2	181					transcription, DNA-dependent	nucleus	zinc ion binding			lung(1)	1		Lung SC(41;0.0262)		BRCA - Breast invasive adenocarcinoma(55;0.000221)|KIRC - Kidney renal clear cell carcinoma(15;0.00834)|Kidney(15;0.00957)		CTCAGACGGCGGGTACGCGGT	0.672		NA											5	2					0	0	0	0
DPPA4	55211	broad.mit.edu	37	3	109047837	109047837	+	Nonsense_Mutation	SNP	T	T	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr3:109047837T>A	uc003dxq.3	-	6	833	c.778A>T	c.(778-780)AAG>TAG	p.K260*	DPPA4_uc011bho.1_Missense_Mutation_p.K161I	NM_018189	NP_060659	Q7L190	DPPA4_HUMAN	developmental pluripotency associated 4	260						nucleus	protein binding			upper_aerodigestive_tract(1)	1						CCTTCTTGCTTTTCTGGAACC	0.517		NA											22	19					0	0	0	0
SEMA5B	54437	broad.mit.edu	37	3	122662294	122662294	+	Silent	SNP	G	G	T			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr3:122662294G>T	uc003efz.1	-	4	721	c.417C>A	c.(415-417)ATC>ATA	p.I139I	SEMA5B_uc011bju.1_Silent_p.I81I|SEMA5B_uc003ega.1_RNA|SEMA5B_uc003egb.1_Silent_p.I139I|SEMA5B_uc010hro.1_Silent_p.I81I|SEMA5B_uc010hrp.1_Intron	NM_001031702	NP_001026872	Q9P283	SEM5B_HUMAN	semaphorin 5B isoform 1	139	Extracellular (Potential).|Sema.				cell differentiation|nervous system development	integral to membrane	receptor activity			ovary(2)|breast(2)|pancreas(2)|central_nervous_system(1)	7				GBM - Glioblastoma multiforme(114;0.0367)		TGGCTCCCACGATGAGCTGGT	0.602		NA											9	16					1.77e-08	2.14e-08	1	0
MYLK	4638	broad.mit.edu	37	3	123333078	123333078	+	Silent	SNP	G	G	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr3:123333078G>A	uc003ego.2	-	34	5901	c.5619C>T	c.(5617-5619)TGC>TGT	p.C1873C	uc003egk.2_Intron|MYLK_uc003egl.2_Silent_p.C113C|MYLK_uc003egm.2_Silent_p.C112C|MYLK_uc010hrr.2_Silent_p.C308C|MYLK_uc011bjv.1_Silent_p.C673C|MYLK_uc011bjw.1_Silent_p.C1872C|MYLK_uc003egp.2_Silent_p.C1804C|MYLK_uc003egq.2_Silent_p.C1822C|MYLK_uc003egr.2_Silent_p.C1753C|MYLK_uc003egs.2_Silent_p.C1697C	NM_053025	NP_444253	Q15746	MYLK_HUMAN	myosin light chain kinase isoform 1	1873	Ig-like C2-type 9.				aorta smooth muscle tissue morphogenesis|muscle contraction	cytosol	actin binding|ATP binding|calmodulin binding|metal ion binding|myosin light chain kinase activity			ovary(6)|skin(2)|stomach(1)	9		Lung NSC(201;0.0496)		GBM - Glioblastoma multiforme(114;0.0736)		CGTCATCCCCGCAAACATCAC	0.498		NA											4	156					0	0	0	0
ZNF148	7707	broad.mit.edu	37	3	125032301	125032301	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr3:125032301C>T	uc003ehx.3	-	4	670	c.184G>A	c.(184-186)GAA>AAA	p.E62K	ZNF148_uc003ehz.3_Missense_Mutation_p.E62K|ZNF148_uc010hsa.2_Missense_Mutation_p.E62K|ZNF148_uc003eia.3_Missense_Mutation_p.E62K|ZNF148_uc003ehy.2_Intron	NM_021964	NP_068799	Q9UQR1	ZN148_HUMAN	zinc finger protein 148	62					cellular defense response|negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	Golgi apparatus|nucleus	protein binding|sequence-specific DNA binding|zinc ion binding			skin(2)|ovary(1)|pancreas(1)	4						TGTAACACTTCATCTGCAGCA	0.443		NA											96	52					0	0	0	0
RHO	6010	broad.mit.edu	37	3	129249874	129249874	+	Missense_Mutation	SNP	G	G	C	rs139731264		TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr3:129249874G>C	uc003emt.2	+	2	612	c.517G>C	c.(517-519)GCC>CCC	p.A173P		NM_000539	NP_000530	P08100	OPSD_HUMAN	rhodopsin	173	Helical; Name=4; (Potential).				protein-chromophore linkage|rhodopsin mediated signaling pathway	Golgi apparatus|integral to plasma membrane|photoreceptor inner segment membrane|photoreceptor outer segment membrane	G-protein coupled receptor activity|metal ion binding|photoreceptor activity|protein binding				0		all_neural(597;0.0227)|Myeloproliferative disorder(1037;0.0255)|Prostate(884;0.183)		GBM - Glioblastoma multiforme(114;2.58e-05)|Lung(219;0.0234)	Halothane(DB01159)	ACCCCCACTCGCCGGCTGGTC	0.612		NA											15	36					0	0	0	0
COL6A6	131873	broad.mit.edu	37	3	130293227	130293227	+	Silent	SNP	G	G	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr3:130293227G>A	uc010htl.2	+	7	3436	c.3405G>A	c.(3403-3405)GTG>GTA	p.V1135V		NM_001102608	NP_001096078	A6NMZ7	CO6A6_HUMAN	collagen type VI alpha 6 precursor	1135	Nonhelical region.|VWFA 6.				axon guidance|cell adhesion	collagen				ovary(6)|central_nervous_system(1)|pancreas(1)	8						TCTACTCCGTGGGCATTGGGG	0.552		NA											45	28					0	0	0	0
CLSTN2	64084	broad.mit.edu	37	3	140167468	140167468	+	Missense_Mutation	SNP	A	A	T			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr3:140167468A>T	uc003etn.2	+	6	1085	c.895A>T	c.(895-897)ACA>TCA	p.T299S	CLSTN2_uc003etm.2_Missense_Mutation_p.T299S	NM_022131	NP_071414	Q9H4D0	CSTN2_HUMAN	calsyntenin 2 precursor	299	Extracellular (Potential).				homophilic cell adhesion	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|plasma membrane	calcium ion binding			skin(3)|large_intestine(2)|pancreas(1)|central_nervous_system(1)	7						CCAGATCGTCACAGAGCTGCA	0.532		NA								HNSCC(16;0.037)			35	127					0	0	0	0
MME	4311	broad.mit.edu	37	3	154802866	154802866	+	Nonsense_Mutation	SNP	C	C	G			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr3:154802866C>G	uc010hvr.1	+	3	390	c.179C>G	c.(178-180)TCA>TGA	p.S60*	MME_uc003fab.1_Nonsense_Mutation_p.S60*|MME_uc003fac.1_Nonsense_Mutation_p.S60*|MME_uc003fad.1_Nonsense_Mutation_p.S60*|MME_uc003fae.1_Nonsense_Mutation_p.S60*	NM_007289	NP_009220	P08473	NEP_HUMAN	membrane metallo-endopeptidase	60	Extracellular (Potential).				cell-cell signaling|proteolysis	integral to plasma membrane	metal ion binding|metalloendopeptidase activity|protein binding			ovary(2)|central_nervous_system(1)	3		all_neural(597;0.00391)|Myeloproliferative disorder(1037;0.0122)	LUSC - Lung squamous cell carcinoma(72;0.114)|Lung(72;0.135)		Candoxatril(DB00616)	tgcaagtcatcagactgcata	0.179		NA											42	12					0	0	0	0
VEPH1	79674	broad.mit.edu	37	3	157146169	157146169	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr3:157146169G>T	uc003fbj.1	-	5	955	c.638C>A	c.(637-639)CCA>CAA	p.P213Q	VEPH1_uc003fbk.1_Missense_Mutation_p.P213Q|VEPH1_uc010hvu.1_Missense_Mutation_p.P213Q	NM_024621	NP_078897	Q14D04	MELT_HUMAN	ventricular zone expressed PH domain homolog 1	213						plasma membrane				breast(3)|ovary(1)|lung(1)	5			Lung(72;0.0272)|LUSC - Lung squamous cell carcinoma(72;0.0461)			GTACTGTTCTGGCTGTTCCAG	0.443		NA											102	28					5.84e-33	8.49e-33	1	0
SI	6476	broad.mit.edu	37	3	164724621	164724621	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr3:164724621C>A	uc003fei.2	-	37	4451	c.4389G>T	c.(4387-4389)CAG>CAT	p.Q1463H		NM_001041	NP_001032	P14410	SUIS_HUMAN	sucrase-isomaltase	1463	Sucrase.|Lumenal.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			ovary(7)|upper_aerodigestive_tract(4)|skin(2)|pancreas(1)	14		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	TAGGTTTCATCTGTGACCATC	0.358		NA								HNSCC(35;0.089)			40	14					3.77e-25	5.39e-25	1	0
SI	6476	broad.mit.edu	37	3	164785240	164785240	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr3:164785240G>C	uc003fei.2	-	6	585	c.523C>G	c.(523-525)CAG>GAG	p.Q175E		NM_001041	NP_001032	P14410	SUIS_HUMAN	sucrase-isomaltase	175	Lumenal.|Isomaltase.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			ovary(7)|upper_aerodigestive_tract(4)|skin(2)|pancreas(1)	14		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	TTTACATACTGATGAGGAACT	0.338		NA								HNSCC(35;0.089)			26	147					0	0	0	0
SLITRK3	22865	broad.mit.edu	37	3	164907946	164907946	+	Missense_Mutation	SNP	T	T	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr3:164907946T>A	uc003fej.3	-	2	1117	c.673A>T	c.(673-675)ATG>TTG	p.M225L	SLITRK3_uc003fek.2_Missense_Mutation_p.M225L	NM_014926	NP_055741	O94933	SLIK3_HUMAN	slit and trk like 3 protein precursor	225	Extracellular (Potential).					integral to membrane				ovary(6)|skin(3)|pancreas(1)	10						TGGAGCTCCATCAGGCTTCTG	0.438		NA								HNSCC(40;0.11)			60	80					0	0	0	0
ZBBX	79740	broad.mit.edu	37	3	167068208	167068208	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr3:167068208C>A	uc003fep.2	-	9	851	c.528G>T	c.(526-528)CAG>CAT	p.Q176H	ZBBX_uc011bpc.1_Missense_Mutation_p.Q176H|ZBBX_uc003feq.2_Missense_Mutation_p.Q147H	NM_024687	NP_078963	A8MT70	ZBBX_HUMAN	zinc finger, B-box domain containing	176						intracellular	zinc ion binding			ovary(2)	2						AAAGCCATACCTGCAAAAGAG	0.343		NA											53	242					8.13e-46	1.19e-45	1	0
MECOM	2122	broad.mit.edu	37	3	168834254	168834254	+	Missense_Mutation	SNP	T	T	C			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr3:168834254T>C	uc003ffi.3	-	7	1111	c.842A>G	c.(841-843)TAT>TGT	p.Y281C	MECOM_uc010hwk.1_Missense_Mutation_p.Y304C|MECOM_uc003ffj.3_Missense_Mutation_p.Y346C|MECOM_uc011bpi.1_Missense_Mutation_p.Y282C|MECOM_uc003ffn.3_Missense_Mutation_p.Y281C|MECOM_uc003ffk.2_Missense_Mutation_p.Y281C|MECOM_uc003ffl.2_Missense_Mutation_p.Y441C|MECOM_uc011bpj.1_Missense_Mutation_p.Y469C|MECOM_uc011bpk.1_Missense_Mutation_p.Y271C|MECOM_uc010hwn.2_Missense_Mutation_p.Y469C	NM_005241	NP_005232	Q03112	EVI1_HUMAN	MDS1 and EVI1 complex locus isoform b	281					apoptosis|cell differentiation|hemopoietic stem cell proliferation|negative regulation of JNK cascade|negative regulation of programmed cell death|negative regulation of transcription, DNA-dependent|regulation of cell cycle	nuclear speck	DNA binding|protein binding|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(5)|skin(5)|upper_aerodigestive_tract(1)|central_nervous_system(1)|ovary(1)|pancreas(1)	14						GGCGCCAAAATAGTCAGCAAG	0.493		NA											15	79					0	0	0	0
TNIK	23043	broad.mit.edu	37	3	170843830	170843830	+	Silent	SNP	C	C	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr3:170843830C>A	uc003fhh.2	-	17	2229	c.1884G>T	c.(1882-1884)GTG>GTT	p.V628V	TNIK_uc003fhi.2_Silent_p.V573V|TNIK_uc003fhj.2_Silent_p.V599V|TNIK_uc003fhk.2_Silent_p.V628V|TNIK_uc003fhl.2_Silent_p.V544V|TNIK_uc003fhm.2_Silent_p.V573V|TNIK_uc003fhn.2_Silent_p.V599V|TNIK_uc003fho.2_Silent_p.V544V	NM_015028	NP_055843	Q9UKE5	TNIK_HUMAN	TRAF2 and NCK interacting kinase isoform 1	628	Mediates interaction with NEDD4.				actin cytoskeleton reorganization|activation of JNKK activity|protein autophosphorylation|regulation of dendrite morphogenesis|Wnt receptor signaling pathway	cytoskeleton|nucleus|recycling endosome	ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			ovary(4)|large_intestine(1)	5	all_cancers(22;2.55e-19)|all_lung(20;2.22e-14)|Ovarian(172;0.00197)|Breast(254;0.122)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)			GGTGGGAGGTCACGTTCAGAG	0.577		NA											18	83					0.00121646	0.00130453	1	0
MAP3K13	9175	broad.mit.edu	37	3	185161246	185161246	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr3:185161246C>T	uc010hyf.2	+	5	939	c.673C>T	c.(673-675)CAG>TAG	p.Q225*	MAP3K13_uc011brt.1_Nonsense_Mutation_p.Q18*|MAP3K13_uc003fph.3_5'UTR|MAP3K13_uc011bru.1_Nonsense_Mutation_p.Q81*|MAP3K13_uc003fpi.2_Nonsense_Mutation_p.Q225*|MAP3K13_uc010hyg.2_Intron	NM_004721	NP_004712	O43283	M3K13_HUMAN	mitogen-activated protein kinase kinase kinase	225	Protein kinase.				activation of MAPKK activity|JNK cascade|positive regulation of NF-kappaB transcription factor activity|protein autophosphorylation	cytoplasm|membrane|membrane fraction	ATP binding|magnesium ion binding|MAP kinase kinase kinase activity|protein homodimerization activity|protein kinase binding			ovary(2)|skin(1)	3	all_cancers(143;7.21e-11)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;1.93e-20)			TGTTTGTACTCAGGCCCCATG	0.308		NA											76	35					0	0	0	0
DOK7	285489	broad.mit.edu	37	4	3494900	3494900	+	Missense_Mutation	SNP	A	A	T			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr4:3494900A>T	uc003ghd.2	+	7	1257	c.1187A>T	c.(1186-1188)CAG>CTG	p.Q396L	DOK7_uc003ghe.2_Missense_Mutation_p.Q258L|DOK7_uc003ghf.2_Missense_Mutation_p.R138W|DOK7_uc003ghg.1_Missense_Mutation_p.Q86L	NM_173660	NP_775931	Q18PE1	DOK7_HUMAN	downstream of tyrosine kinase 7 isoform 1	396					positive regulation of protein tyrosine kinase activity	cell junction|synapse	insulin receptor binding|protein kinase binding			skin(1)	1				UCEC - Uterine corpus endometrioid carcinoma (64;0.163)		GTCGAGTACCAGGTGCCCACC	0.692		NA											6	10					0	0	0	0
LRPAP1	4043	broad.mit.edu	37	4	3516631	3516631	+	Nonsense_Mutation	SNP	T	T	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr4:3516631T>A	uc003ghi.2	-	7	944	c.859A>T	c.(859-861)AAA>TAA	p.K287*		NM_002337	NP_002328	P30533	AMRP_HUMAN	low density lipoprotein receptor-related protein	287	LDL receptor binding (Potential).|Potential.				negative regulation of protein binding|negative regulation of very-low-density lipoprotein particle clearance|protein folding|vesicle-mediated transport	cell surface|integral to membrane|plasma membrane	asialoglycoprotein receptor activity|heparin binding|low-density lipoprotein particle receptor binding|receptor antagonist activity|unfolded protein binding|very-low-density lipoprotein particle receptor binding			ovary(1)|skin(1)	2				UCEC - Uterine corpus endometrioid carcinoma (64;0.165)		TTCTCGATTTTGGCTTCGAAG	0.592		NA											43	92					0	0	0	0
ZNF518B	85460	broad.mit.edu	37	4	10444812	10444812	+	Silent	SNP	G	G	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr4:10444812G>A	uc003gmn.2	-	3	3628	c.3141C>T	c.(3139-3141)GAC>GAT	p.D1047D		NM_053042	NP_444270	Q9C0D4	Z518B_HUMAN	zinc finger protein 518B	1047	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)|upper_aerodigestive_tract(1)	4						ACTCTTCCTGGTCTTCATACA	0.413		NA											31	80					0	0	0	0
KCNIP4	80333	broad.mit.edu	37	4	21305453	21305454	+	Missense_Mutation	DNP	CC	CC	AG			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr4:21305453_21305454CC>AG	uc003gqf.1	-	1	76_77	c.76_77GG>CT	c.(76-78)GGG>CTG	p.G26L	KCNIP4_uc003gqg.1_Intron|KCNIP4_uc003gqh.1_Intron|KCNIP4_uc003gqi.1_Intron	NM_147183	NP_671712	Q6PIL6	KCIP4_HUMAN	Kv channel interacting protein 4 isoform 4	Error:Variant_position_missing_in_Q6PIL6_after_alignment						plasma membrane	calcium ion binding|potassium channel activity|protein binding|voltage-gated ion channel activity				0		Breast(46;0.134)				TTCAATCAGCCCAAACTGTTCC	0.396		NA											8	37					0	0	0	0
ARAP2	116984	broad.mit.edu	37	4	36075423	36075423	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr4:36075423G>C	uc003gsq.1	-	32	4969	c.4631C>G	c.(4630-4632)CCA>CGA	p.P1544R	ARAP2_uc003gso.2_RNA	NM_015230	NP_056045	Q8WZ64	ARAP2_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH	1544					regulation of ARF GTPase activity|small GTPase mediated signal transduction	cytosol	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|zinc ion binding			ovary(1)|pancreas(1)|skin(1)	3						CTTTCCAGCTGGTGGCCATAT	0.413		NA											36	67					0	0	0	0
PHOX2B	8929	broad.mit.edu	37	4	41749478	41749478	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr4:41749478G>C	uc003gwf.3	-	2	677	c.317C>G	c.(316-318)ACC>AGC	p.T106S		NM_003924	NP_003915	Q99453	PHX2B_HUMAN	paired-like homeobox 2b	106	Homeobox.				positive regulation of transcription from RNA polymerase II promoter	nuclear chromatin	RNA polymerase II regulatory region sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription cofactor activity			autonomic_ganglia(7)|lung(2)|ovary(2)|central_nervous_system(1)	12						CTGGGCACTGGTGAAAGTGGT	0.572		NA	Mis|F		neuroblastoma	neuroblastoma	congenital central hypoventilation syndrome		Neuroblastoma_Familial_Clustering_of|Congenital_Central_Hypoventilation_Syndrome				23	59					0	0	0	0
PDGFRA	5156	broad.mit.edu	37	4	55156559	55156559	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr4:55156559C>A	uc003han.3	+	22	3291	c.2960C>A	c.(2959-2961)GCA>GAA	p.A987E	PDGFRA_uc003haa.2_Missense_Mutation_p.A747E	NM_006206	NP_006197	P16234	PGFRA_HUMAN	platelet-derived growth factor receptor alpha	987	Cytoplasmic (Potential).				cardiac myofibril assembly|cell activation|luteinization|metanephric glomerular capillary formation|peptidyl-tyrosine phosphorylation|positive regulation of cell migration|positive regulation of DNA replication|positive regulation of fibroblast proliferation|protein autophosphorylation|retina vasculature development in camera-type eye	cytoplasm|integral to plasma membrane|nucleus	ATP binding|platelet-derived growth factor alpha-receptor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|protein homodimerization activity|vascular endothelial growth factor receptor activity			soft_tissue(572)|small_intestine(40)|stomach(16)|lung(16)|central_nervous_system(13)|haematopoietic_and_lymphoid_tissue(7)|skin(3)|ovary(3)|gastrointestinal_tract_(site_indeterminate)(1)|autonomic_ganglia(1)|prostate(1)|bone(1)	674	all_cancers(7;0.000425)|all_lung(4;0.000343)|Lung NSC(11;0.000467)|all_epithelial(27;0.0131)|all_neural(26;0.0209)|Glioma(25;0.08)		GBM - Glioblastoma multiforme(1;4.18e-71)|all cancers(1;4.76e-45)|LUSC - Lung squamous cell carcinoma(32;0.00256)		Becaplermin(DB00102)|Imatinib(DB00619)|Sunitinib(DB01268)	TCAGACAATGCATACATTGGT	0.468		NA	Mis|O|T	FIP1L1	GIST|idiopathic hypereosinophilic syndrome				Gastrointestinal_Stromal_Tumors_Sporadic_Multiple_Primary|Familial_Intestinal_Neurofibromatosis	TSP Lung(21;0.16)			28	82					2.13e-12	2.77e-12	1	0
KIT	3815	broad.mit.edu	37	4	55592133	55592133	+	Missense_Mutation	SNP	A	A	T			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr4:55592133A>T	uc010igr.2	+	9	1544	c.1457A>T	c.(1456-1458)AAT>ATT	p.N486I	KIT_uc010igs.2_Missense_Mutation_p.N486I|KIT_uc011bzw.1_5'Flank|KIT_uc010igt.1_5'Flank	NM_000222	NP_000213	P10721	KIT_HUMAN	v-kit Hardy-Zuckerman 4 feline sarcoma viral	486	Extracellular (Potential).|Ig-like C2-type 5.				male gonad development|transmembrane receptor protein tyrosine kinase signaling pathway	extracellular space|integral to membrane	ATP binding|protein binding|receptor signaling protein tyrosine kinase activity	p.N486D(1)|p.D479fs*2(1)		soft_tissue(3273)|haematopoietic_and_lymphoid_tissue(1572)|skin(99)|testis(49)|bone(21)|genital_tract(18)|kidney(17)|ovary(16)|salivary_gland(15)|large_intestine(11)|thymus(6)|lung(6)|central_nervous_system(4)|NS(3)|eye(2)|endometrium(2)|breast(1)|stomach(1)|autonomic_ganglia(1)|pancreas(1)	5118	all_cancers(7;0.00453)|all_lung(4;0.000565)|Lung NSC(11;0.00129)|all_epithelial(27;0.0104)|Glioma(25;0.08)|all_neural(26;0.101)		LUSC - Lung squamous cell carcinoma(32;0.000276)|Epithelial(7;0.209)	Colorectal(1;0.0276)|COAD - Colon adenocarcinoma(1;0.171)	Dasatinib(DB01254)|Imatinib(DB00619)|Sorafenib(DB00398)|Sunitinib(DB01268)	TTCAAGCACAATGGCACGGTT	0.403		1	Mis|O		GIST|AML|TGCT|mastocytosis|mucosal melanoma	GIST|epithelioma	Piebald trait		Mast_Cell_disease_Familial_Clustering_of|Piebaldism|Gastrointestinal_Stromal_Tumors_Sporadic_Multiple_Primary|Familial_Gastrointestinal_Stromal_Tumors				24	50					0	0	0	0
KDR	3791	broad.mit.edu	37	4	55987310	55987310	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr4:55987310C>T	uc003has.2	-	2	417	c.115G>A	c.(115-117)GAC>AAC	p.D39N	KDR_uc003hat.1_Missense_Mutation_p.D39N|KDR_uc011bzx.1_Missense_Mutation_p.D39N	NM_002253	NP_002244	P35968	VGFR2_HUMAN	kinase insert domain receptor precursor	39	Extracellular (Potential).				angiogenesis|cell differentiation|interspecies interaction between organisms|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of focal adhesion assembly|positive regulation of positive chemotaxis|regulation of cell shape	integral to plasma membrane	ATP binding|growth factor binding|Hsp90 protein binding|integrin binding|receptor signaling protein tyrosine kinase activity|vascular endothelial growth factor receptor activity			lung(16)|soft_tissue(4)|central_nervous_system(4)|large_intestine(2)|stomach(2)|skin(2)|ovary(2)|kidney(1)	33	all_cancers(7;0.0255)|all_lung(4;0.00175)|Lung NSC(11;0.00384)|all_epithelial(27;0.034)|Glioma(25;0.08)|all_neural(26;0.101)		Epithelial(7;0.189)		Sorafenib(DB00398)|Sunitinib(DB01268)	GTAAGTATGTCTTTTTGTATG	0.333		NA	Mis		NSCLC|angiosarcoma				Familial_Infantile_Hemangioma	TSP Lung(20;0.16)			16	62					0	0	0	0
KIAA1211	57482	broad.mit.edu	37	4	57190344	57190344	+	Silent	SNP	A	A	G			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr4:57190344A>G	uc003hbk.2	+	10	3844	c.3453A>G	c.(3451-3453)CCA>CCG	p.P1151P	KIAA1211_uc010iha.2_Silent_p.P1144P	NM_020722	NP_065773	Q6ZU35	K1211_HUMAN	hypothetical protein LOC57482	1151										ovary(1)|skin(1)	2	Glioma(25;0.08)|all_neural(26;0.101)					CTGCTCTGCCAGAAGAGAAGA	0.572		NA											16	37					0	0	0	0
TECRL	253017	broad.mit.edu	37	4	65180375	65180375	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr4:65180375G>A	uc003hcv.2	-	5	651	c.542C>T	c.(541-543)CCA>CTA	p.P181L	TECRL_uc003hcw.2_Missense_Mutation_p.P181L	NM_001010874	NP_001010874	Q5HYJ1	TECRL_HUMAN	steroid 5 alpha-reductase 2-like 2	181					lipid metabolic process	cytoplasm|integral to membrane	oxidoreductase activity, acting on the CH-CH group of donors				0						CTGTACCACTGGGTGGCGTAA	0.303		NA											19	42					0	0	0	0
TMPRSS11F	389208	broad.mit.edu	37	4	68919654	68919654	+	Silent	SNP	A	A	G			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr4:68919654A>G	uc003hdt.1	-	10	1339	c.1290T>C	c.(1288-1290)GAT>GAC	p.D430D	LOC550112_uc003hdl.3_Intron|uc011cak.1_Intron	NM_207407	NP_997290	Q6ZWK6	TM11F_HUMAN	transmembrane protease, serine 11F	430	Peptidase S1.|Extracellular (Potential).				proteolysis	extracellular region|integral to plasma membrane	serine-type endopeptidase activity			ovary(1)	1						AGGCAATCCAATCTCGATACT	0.408		NA											33	60					0	0	0	0
UGT2B10	7365	broad.mit.edu	37	4	69693223	69693223	+	Missense_Mutation	SNP	A	A	G			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr4:69693223A>G	uc003hee.2	+	5	1289	c.1264A>G	c.(1264-1266)ACA>GCA	p.T422A	UGT2B10_uc011cam.1_Missense_Mutation_p.T338A	NM_001075	NP_001066	P36537	UDB10_HUMAN	UDP glucuronosyltransferase 2B10 isoform 1	422					lipid metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			skin(3)|ovary(2)	5						AATGTCGAGTACAGACCTGCT	0.388		NA											53	91					0	0	0	0
UGT2B7	7364	broad.mit.edu	37	4	69978304	69978304	+	Silent	SNP	C	C	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr4:69978304C>A	uc003heg.3	+	6	1486	c.1440C>A	c.(1438-1440)GCC>GCA	p.A480A	UGT2B7_uc010ihq.2_3'UTR	NM_001074	NP_001065	P16662	UD2B7_HUMAN	UDP glucuronosyltransferase 2B7 precursor	480					lipid metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			ovary(1)|skin(1)	2						GGGTTGCAGCCCACGACCTCA	0.483		NA											52	118					4.26e-23	6e-23	1	0
GC	2638	broad.mit.edu	37	4	72622457	72622457	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr4:72622457C>A	uc003hge.2	-	8	1159	c.1006G>T	c.(1006-1008)GAT>TAT	p.D336Y	GC_uc003hgd.2_Missense_Mutation_p.D214Y|GC_uc010iie.2_Missense_Mutation_p.D336Y|GC_uc010iif.2_Missense_Mutation_p.D355Y	NM_000583	NP_000574	P02774	VTDB_HUMAN	vitamin D-binding protein precursor	336	Albumin 2.				hormone biosynthetic process|vitamin D metabolic process	cytosol|lysosomal lumen	actin binding|vitamin D binding|vitamin transporter activity			ovary(2)|upper_aerodigestive_tract(1)	3		all_hematologic(202;0.107)	Lung(101;0.148)		Cholecalciferol(DB00169)	TTTCCTGGATCACACACATCT	0.453		NA											8	33					5.18e-06	5.92e-06	1	0
GC	2638	broad.mit.edu	37	4	72629169	72629169	+	Silent	SNP	G	G	C			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr4:72629169G>C	uc003hge.2	-	6	810	c.657C>G	c.(655-657)GTC>GTG	p.V219V	GC_uc003hgd.2_Silent_p.V97V|GC_uc010iie.2_Silent_p.V219V|GC_uc010iif.2_Silent_p.V238V	NM_000583	NP_000574	P02774	VTDB_HUMAN	vitamin D-binding protein precursor	219	Albumin 2.				hormone biosynthetic process|vitamin D metabolic process	cytosol|lysosomal lumen	actin binding|vitamin D binding|vitamin transporter activity			ovary(2)|upper_aerodigestive_tract(1)	3		all_hematologic(202;0.107)	Lung(101;0.148)		Cholecalciferol(DB00169)	ATTGTGAGCAGACTCTATTTG	0.368		NA											16	39					0	0	0	0
NAA11	84779	broad.mit.edu	37	4	80247017	80247017	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr4:80247017G>C	uc003hlt.3	-	1	155	c.15C>G	c.(13-15)AAC>AAG	p.N5K		NM_032693	NP_116082	Q9BSU3	NAA11_HUMAN	alpha-N-acetyltransferase 1B	5	Interaction with NAA15 (By similarity).|N-acetyltransferase.					cytoplasm|nucleus	peptide alpha-N-acetyltransferase activity|protein binding			ovary(1)|central_nervous_system(1)	2						CTGGCTGAGCGTTGCGGATGT	0.512		NA											13	24					0	0	0	0
AGXT2L1	64850	broad.mit.edu	37	4	109674060	109674060	+	Missense_Mutation	SNP	A	A	T			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr4:109674060A>T	uc003hzc.2	-	6	790	c.609T>A	c.(607-609)AGT>AGA	p.S203R	AGXT2L1_uc010imc.2_Missense_Mutation_p.S197R|AGXT2L1_uc011cfm.1_Missense_Mutation_p.S163R|AGXT2L1_uc011cfn.1_Missense_Mutation_p.S130R|AGXT2L1_uc011cfo.1_Missense_Mutation_p.S145R	NM_031279	NP_112569	Q8TBG4	AT2L1_HUMAN	alanine-glyoxylate aminotransferase 2-like 1	203					cellular amino acid metabolic process	mitochondrion	alanine-glyoxylate transaminase activity|pyridoxal phosphate binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(123;0.000281)		CCTTCCTTCCACTGTTATGAG	0.363		NA											33	86					0	0	0	0
ENPEP	2028	broad.mit.edu	37	4	111452358	111452358	+	Missense_Mutation	SNP	A	A	G			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr4:111452358A>G	uc003iab.3	+	11	2074	c.1732A>G	c.(1732-1734)ACA>GCA	p.T578A		NM_001977	NP_001968	Q07075	AMPE_HUMAN	glutamyl aminopeptidase	578	Extracellular (Potential).				cell migration|cell proliferation|cell-cell signaling|proteolysis	integral to plasma membrane	aminopeptidase activity|metalloexopeptidase activity|zinc ion binding			skin(3)|ovary(1)|breast(1)	5		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.0031)	L-Glutamic Acid(DB00142)	ttttaGTTATACATGGAATAT	0.184		NA											15	22					0	0	0	0
ANK2	287	broad.mit.edu	37	4	114214656	114214656	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr4:114214656C>A	uc003ibe.3	+	22	2537	c.2437C>A	c.(2437-2439)CTG>ATG	p.L813M	ANK2_uc003ibd.3_Missense_Mutation_p.L792M|ANK2_uc003ibf.3_Missense_Mutation_p.L813M|ANK2_uc011cgc.1_Missense_Mutation_p.L22M|ANK2_uc003ibc.2_Missense_Mutation_p.L789M|ANK2_uc011cgb.1_Missense_Mutation_p.L828M	NM_001148	NP_001139	Q01484	ANK2_HUMAN	ankyrin 2 isoform 1	813	ANK 24.				axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding|protein binding			central_nervous_system(7)|ovary(3)|large_intestine(2)|breast(1)|skin(1)	14		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		GGTCGACACCCTGAAGGTTGT	0.408		NA											17	26					5.39e-06	6.14e-06	1	0
PHF17	79960	broad.mit.edu	37	4	129770159	129770159	+	Silent	SNP	C	C	T			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr4:129770159C>T	uc003igk.2	+	5	601	c.321C>T	c.(319-321)CTC>CTT	p.L107L	PHF17_uc003igj.2_Silent_p.L107L|PHF17_uc003igl.2_Intron|PHF17_uc011cgy.1_Silent_p.L107L|PHF17_uc003igm.2_Silent_p.L107L	NM_199320	NP_955352	Q6IE81	JADE1_HUMAN	PHD finger protein 17 long isoform	107					apoptosis|histone H3 acetylation|histone H4-K12 acetylation|histone H4-K5 acetylation|histone H4-K8 acetylation|negative regulation of cell growth|regulation of transcription, DNA-dependent|response to stress|transcription, DNA-dependent	histone acetyltransferase complex|mitochondrion	protein binding|zinc ion binding				0						AGAAATCCCTCATGTTCATCA	0.517		NA											28	64					0	0	0	0
PCDH18	54510	broad.mit.edu	37	4	138452706	138452706	+	Missense_Mutation	SNP	A	A	T			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr4:138452706A>T	uc003ihe.3	-	1	924	c.537T>A	c.(535-537)AAT>AAA	p.N179K	PCDH18_uc003ihf.3_Missense_Mutation_p.N172K|PCDH18_uc011cgz.1_Intron|PCDH18_uc003ihg.3_5'UTR|PCDH18_uc011cha.1_Intron	NM_019035	NP_061908	Q9HCL0	PCD18_HUMAN	protocadherin 18 precursor	179	Extracellular (Potential).|Cadherin 2.				brain development|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			pancreas(3)|skin(2)	5	all_hematologic(180;0.24)					TAAAAAAATCATTGGCAGAGA	0.483		NA											17	40					0	0	0	0
RNF150	57484	broad.mit.edu	37	4	142053645	142053645	+	Silent	SNP	G	G	T			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr4:142053645G>T	uc003iio.1	-	1	972	c.318C>A	c.(316-318)ACC>ACA	p.T106T	RNF150_uc010iok.1_Silent_p.T106T|RNF150_uc003iip.1_Silent_p.T106T	NM_020724	NP_065775	Q9ULK6	RN150_HUMAN	ring finger protein 150 precursor	106	Extracellular (Potential).|PA.					integral to membrane	zinc ion binding			ovary(1)	1	all_hematologic(180;0.162)					CGGCGAACTTGGTGTTGGGGT	0.672		NA											8	10					5.18e-06	5.92e-06	1	0
GUCY1A3	2982	broad.mit.edu	37	4	156629432	156629432	+	Missense_Mutation	SNP	A	A	C			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr4:156629432A>C	uc003iov.2	+	6	898	c.362A>C	c.(361-363)CAA>CCA	p.Q121P	GUCY1A3_uc003iou.2_Missense_Mutation_p.Q121P|GUCY1A3_uc010iqc.2_Missense_Mutation_p.Q121P|GUCY1A3_uc003iow.2_Missense_Mutation_p.Q121P|GUCY1A3_uc010iqd.2_Missense_Mutation_p.Q121P|GUCY1A3_uc003iox.2_Missense_Mutation_p.Q121P|GUCY1A3_uc003ioz.2_5'UTR|GUCY1A3_uc003ioy.2_Missense_Mutation_p.Q121P|GUCY1A3_uc010iqe.2_5'UTR|GUCY1A3_uc003ipa.2_RNA|GUCY1A3_uc003ipb.2_Missense_Mutation_p.Q121P	NM_000856	NP_000847	Q02108	GCYA3_HUMAN	guanylate cyclase 1, soluble, alpha 3 isoform A	121					blood circulation|intracellular signal transduction|nitric oxide mediated signal transduction|platelet activation	guanylate cyclase complex, soluble	GTP binding|guanylate cyclase activity|heme binding|receptor activity			central_nervous_system(2)|ovary(1)|skin(1)	4	all_hematologic(180;0.24)	Renal(120;0.0854)		COAD - Colon adenocarcinoma(41;0.17)		ATTGCAGAGCAAGCAGTTGCA	0.274		NA											29	56					0	0	0	0
NPY1R	4886	broad.mit.edu	37	4	164247365	164247365	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr4:164247365C>G	uc003iqm.1	-	2	608	c.342G>C	c.(340-342)AAG>AAC	p.K114N	NPY1R_uc011cjj.1_Intron	NM_000909	NP_000900	P25929	NPY1R_HUMAN	neuropeptide Y receptor Y1	114	Extracellular (Potential).				inhibition of adenylate cyclase activity by G-protein signaling pathway|outflow tract morphogenesis	integral to plasma membrane	protein binding			lung(1)|pancreas(1)	2	all_hematologic(180;0.166)	Prostate(90;0.0959)|all_neural(102;0.223)				AAGGATTCAACTTACACATCG	0.443		NA											19	46					0	0	0	0
TRIM60	166655	broad.mit.edu	37	4	165962140	165962140	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr4:165962140C>A	uc003iqy.1	+	3	1086	c.916C>A	c.(916-918)CCT>ACT	p.P306T	TRIM60_uc010iqx.1_Missense_Mutation_p.P306T	NM_152620	NP_689833	Q495X7	TRI60_HUMAN	ring finger protein 129	306	B30.2/SPRY.					intracellular	zinc ion binding			skin(1)	1	all_hematologic(180;0.221)	Prostate(90;0.0959)|Melanoma(52;0.18)		GBM - Glioblastoma multiforme(119;0.0844)		CACAGCACATCCTCAACTTCT	0.383		NA											36	77					9.46e-24	1.34e-23	1	0
DDX60L	91351	broad.mit.edu	37	4	169305796	169305796	+	Silent	SNP	G	G	T			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr4:169305796G>T	uc003irq.3	-	30	4304	c.4083C>A	c.(4081-4083)TCC>TCA	p.S1361S		NM_001012967	NP_001012985	Q5H9U9	DDX6L_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like	1361							ATP binding|ATP-dependent helicase activity|RNA binding			ovary(1)	1		Prostate(90;0.00876)|Renal(120;0.0183)|all_neural(102;0.0837)|Melanoma(52;0.132)		GBM - Glioblastoma multiforme(119;0.175)		CATCTCCCTTGGAAGCCAGCA	0.547		NA											10	22					9.7e-10	1.21e-09	1	0
PALLD	23022	broad.mit.edu	37	4	169630280	169630280	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr4:169630280C>A	uc011cjx.1	+	9	1814	c.1603C>A	c.(1603-1605)CAG>AAG	p.Q535K	PALLD_uc003iru.2_Missense_Mutation_p.Q535K|PALLD_uc003irv.2_Missense_Mutation_p.Q153K	NM_016081	NP_057165	Q8WX93	PALLD_HUMAN	palladin isoform 2	535	Ig-like C2-type 2.				cytoskeleton organization	actin filament|focal adhesion|lamellipodium|nucleus|ruffle|sarcomere	actin binding|muscle alpha-actinin binding			ovary(1)	1		Prostate(90;0.00996)|Renal(120;0.0203)|Melanoma(52;0.144)		GBM - Glioblastoma multiforme(119;0.204)		CAGCACTGCCCAGCTGGTTGT	0.488		NA							Pancreatic_Cancer_Familial_Clustering_of				23	45					9.58e-11	1.22e-10	1	0
IRX1	79192	broad.mit.edu	37	5	3599662	3599663	+	Nonsense_Mutation	DNP	GG	GG	CT			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr5:3599662_3599663GG>CT	uc003jde.2	+	2	652_653	c.600_601GG>CT	c.(598-603)CAGGAA>CACTAA	p.200_201QE>H*		NM_024337	NP_077313	P78414	IRX1_HUMAN	iroquois homeobox protein 1	200_201						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|pancreas(1)	2						GCAAGGACCAGGAAGATGGAGC	0.624		NA											35	56					0	0	0	0
SEMA5A	9037	broad.mit.edu	37	5	9154600	9154600	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr5:9154600C>A	uc003jek.2	-	12	2193	c.1481G>T	c.(1480-1482)AGC>ATC	p.S494I		NM_003966	NP_003957	Q13591	SEM5A_HUMAN	semaphorin 5A precursor	494	Extracellular (Potential).			S -> R (in Ref. 2; AAC14668).	cell adhesion|cell-cell signaling	integral to membrane|plasma membrane				ovary(1)|central_nervous_system(1)	2						GATGCCCTACCTGCGTGTGCG	0.612		NA											38	39					3.28e-08	3.96e-08	1	0
ADAMTS12	81792	broad.mit.edu	37	5	33535075	33535075	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr5:33535075C>A	uc003jia.1	-	23	4632	c.4469G>T	c.(4468-4470)GGC>GTC	p.G1490V	ADAMTS12_uc010iuq.1_Missense_Mutation_p.G1405V	NM_030955	NP_112217	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1	1490	TSP type-1 8.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|kidney(1)	9						CTTCTGAAAGCCACCTCCACA	0.493		NA								HNSCC(64;0.19)			32	44					1.56e-22	2.2e-22	1	0
WDR70	55100	broad.mit.edu	37	5	37727134	37727134	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr5:37727134C>T	uc003jkv.2	+	17	1922	c.1864C>T	c.(1864-1866)CCA>TCA	p.P622S		NM_018034	NP_060504	Q9NW82	WDR70_HUMAN	WD repeat domain 70	622										ovary(1)|central_nervous_system(1)	2	all_lung(31;0.000285)		COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			TTGGGTTTCTCCAGCATATTC	0.383		NA											68	88					0	0	0	0
C9	735	broad.mit.edu	37	5	39306836	39306836	+	Silent	SNP	G	G	C			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr5:39306836G>C	uc003jlv.3	-	9	1388	c.1299C>G	c.(1297-1299)ACC>ACG	p.T433T		NM_001737	NP_001728	P02748	CO9_HUMAN	complement component 9 precursor	433	MACPF.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis|hemolysis by symbiont of host erythrocytes	extracellular region|membrane attack complex					0	all_lung(31;0.000197)	all_neural(839;7.57e-10)|Lung NSC(810;2.62e-08)|Ovarian(839;0.00384)|Breast(839;0.0184)|Myeloproliferative disorder(839;0.0511)	Epithelial(62;0.158)			CATATTTTCTGGTTCCACCTC	0.403		NA											32	73					0	0	0	0
CARD6	84674	broad.mit.edu	37	5	40843302	40843302	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr5:40843302G>C	uc003jmg.2	+	2	407	c.332G>C	c.(331-333)AGC>ACC	p.S111T		NM_032587	NP_115976	Q9BX69	CARD6_HUMAN	caspase recruitment domain family, member 6	111					apoptosis|regulation of apoptosis	intracellular				ovary(2)|skin(2)|lung(1)	5						ATGGGGGCAAGCAGTAATTCA	0.383		NA											50	83					0	0	0	0
C6	729	broad.mit.edu	37	5	41160245	41160245	+	Silent	SNP	G	G	T			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr5:41160245G>T	uc003jmk.2	-	11	1893	c.1683C>A	c.(1681-1683)TCC>TCA	p.S561S	C6_uc003jml.1_Silent_p.S561S	NM_000065	NP_000056	P13671	CO6_HUMAN	complement component 6 precursor	561					complement activation, classical pathway|cytolysis|innate immune response	membrane attack complex	protein binding			ovary(3)|central_nervous_system(2)|skin(2)	7		Breast(839;1.07e-05)|Ovarian(839;0.0228)|Lung SC(612;0.0548)|Lung NSC(810;0.128)|all_neural(839;0.157)				GATACTTACTGGATTTATAAT	0.408		NA											50	94					3.68e-26	5.27e-26	1	0
HMGCS1	3157	broad.mit.edu	37	5	43298817	43298817	+	Missense_Mutation	SNP	T	T	C			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr5:43298817T>C	uc003jnr.3	-	3	458	c.251A>G	c.(250-252)TAT>TGT	p.Y84C	HMGCS1_uc003jnq.3_Missense_Mutation_p.Y84C	NM_001098272	NP_001091742	Q01581	HMCS1_HUMAN	hydroxymethylglutaryl-CoA synthase 1	84					cholesterol biosynthetic process|isoprenoid biosynthetic process	cytosol|soluble fraction	hydroxymethylglutaryl-CoA synthase activity				0						AATGCAATCATAGGAAAGGTT	0.428		NA											70	116					0	0	0	0
HCN1	348980	broad.mit.edu	37	5	45262356	45262356	+	Silent	SNP	G	G	C			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr5:45262356G>C	uc003jok.2	-	8	2365	c.2340C>G	c.(2338-2340)ACC>ACG	p.T780T		NM_021072	NP_066550	O60741	HCN1_HUMAN	hyperpolarization activated cyclic	780	Cytoplasmic (Potential).					integral to membrane	cAMP binding|sodium channel activity|voltage-gated potassium channel activity			ovary(1)	1						TGACTTCCCGGGTCAGGTTGG	0.592		NA											22	61					0	0	0	0
HCN1	348980	broad.mit.edu	37	5	45396681	45396681	+	Silent	SNP	G	G	T			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr5:45396681G>T	uc003jok.2	-	4	1168	c.1143C>A	c.(1141-1143)GTC>GTA	p.V381V		NM_021072	NP_066550	O60741	HCN1_HUMAN	hyperpolarization activated cyclic	381	Helical; Name=Segment S6; (Potential).					integral to membrane	cAMP binding|sodium channel activity|voltage-gated potassium channel activity			ovary(1)	1						AGGTGGCCCCGACGATCATGC	0.507		NA											18	75					5.04e-11	6.44e-11	1	0
BDP1	55814	broad.mit.edu	37	5	70798483	70798483	+	Silent	SNP	A	A	G			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr5:70798483A>G	uc003kbp.1	+	15	2369	c.2106A>G	c.(2104-2106)GTA>GTG	p.V702V	BDP1_uc003kbn.1_Silent_p.V702V|BDP1_uc003kbo.2_Silent_p.V702V	NM_018429	NP_060899	A6H8Y1	BDP1_HUMAN	transcription factor-like nuclear regulator	702					regulation of transcription, DNA-dependent|transcription from RNA polymerase III promoter	nucleoplasm	DNA binding			skin(2)	2		Lung NSC(167;0.000422)|Prostate(74;0.00815)|Ovarian(174;0.0176)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;5.28e-56)|Epithelial(20;2.31e-50)		TAAGACCTGTACAAGTGAGGG	0.383		NA											23	14					0	0	0	0
MAP1B	4131	broad.mit.edu	37	5	71492996	71492996	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr5:71492996C>A	uc003kbw.3	+	5	4055	c.3814C>A	c.(3814-3816)CTG>ATG	p.L1272M	MAP1B_uc010iyw.1_Missense_Mutation_p.L1289M|MAP1B_uc010iyx.1_Missense_Mutation_p.L1146M|MAP1B_uc010iyy.1_Missense_Mutation_p.L1146M	NM_005909	NP_005900	P46821	MAP1B_HUMAN	microtubule-associated protein 1B	1272						microtubule|microtubule associated complex	structural molecule activity			large_intestine(2)|ovary(1)|central_nervous_system(1)|pancreas(1)	5		Lung NSC(167;0.00202)|Ovarian(174;0.0175)|Prostate(461;0.142)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;7.99e-54)		AAAGACCCCCCTGGGTGAACG	0.517		NA											51	23					3.86e-30	5.59e-30	1	0
NSA2	10412	broad.mit.edu	37	5	74069717	74069717	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr5:74069717G>C	uc003kdk.1	+	5	630	c.547G>C	c.(547-549)GTA>CTA	p.V183L		NM_014886	NP_055701	O95478	NSA2_HUMAN	NSA2 ribosome biogenesis homolog	183					rRNA processing	nucleolus|ribonucleoprotein complex				ovary(1)	1						GAAAGCCCATGTAACACATCC	0.403		NA											31	20					0	0	0	0
MEF2C	4208	broad.mit.edu	37	5	88119602	88119603	+	Missense_Mutation	DNP	CC	CC	AA			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr5:88119602_88119603CC>AA	uc003kjj.2	-	2	676_677	c.3_4GG>TT	c.(1-6)ATGGGG>ATTTGG	p.1_2MG>IW	MEF2C_uc003kji.2_Missense_Mutation_p.1_2MG>IW|MEF2C_uc003kjk.2_Missense_Mutation_p.1_2MG>IW|MEF2C_uc003kjm.2_Missense_Mutation_p.1_2MG>IW|MEF2C_uc003kjl.2_Missense_Mutation_p.1_2MG>IW	NM_002397	NP_002388	Q06413	MEF2C_HUMAN	myocyte enhancer factor 2C isoform 1	1_2					apoptosis|B cell proliferation|innate immune response|learning or memory|muscle cell differentiation|muscle organ development|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|nerve growth factor receptor signaling pathway|neuron development|positive regulation of muscle cell differentiation|positive regulation of survival gene product expression|positive regulation of transcription from RNA polymerase II promoter|regulation of germinal center formation|regulation of megakaryocyte differentiation|regulation of synaptic activity|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	nuclear speck	activating transcription factor binding|protein heterodimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			lung(3)|breast(2)|ovary(1)|large_intestine(1)	7		all_cancers(142;6.67e-05)|all_epithelial(76;7.77e-07)|Lung NSC(167;0.00566)|all_lung(232;0.00732)|Colorectal(57;0.0959)|Ovarian(174;0.1)		OV - Ovarian serous cystadenocarcinoma(54;1.04e-33)|Epithelial(54;1.6e-28)|all cancers(79;2.9e-25)		TTTTTTCTCCCCATAGTCCCCG	0.342		NA								HNSCC(66;0.2)			136	137					0	0	0	0
GPR98	84059	broad.mit.edu	37	5	89986666	89986666	+	Silent	SNP	G	G	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr5:89986666G>A	uc003kju.2	+	31	6855	c.6759G>A	c.(6757-6759)AAG>AAA	p.K2253K	GPR98_uc003kjt.2_5'UTR	NM_032119	NP_115495	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98 precursor	2253	Extracellular (Potential).				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(11)|central_nervous_system(3)|pancreas(2)	16		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		ACTCAGTGAAGGTAAACCTGC	0.428		NA											17	10					0	0	0	0
POU5F2	134187	broad.mit.edu	37	5	93076445	93076445	+	Silent	SNP	C	C	T			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr5:93076445C>T	uc003kkl.1	-	1	865	c.825G>A	c.(823-825)CGG>CGA	p.R275R	FAM172A_uc010jbd.2_Intron|FAM172A_uc011cuf.1_Intron|FAM172A_uc011cug.1_Intron|FAM172A_uc011cuh.1_Intron|FAM172A_uc011cui.1_Intron|FAM172A_uc011cuj.1_Intron	NM_153216	NP_694948	Q8N7G0	PO5F2_HUMAN	POU domain class 5, transcription factor 2	275						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0		all_cancers(142;3.87e-05)|all_epithelial(76;4.59e-07)|all_lung(232;0.0126)|Lung NSC(167;0.0155)|Ovarian(174;0.0218)|Prostate(281;0.173)|Colorectal(57;0.19)		UCEC - Uterine corpus endometrioid carcinoma (5;0.0415)|all cancers(79;2.03e-19)		CCACAATCTCCCGTGGGGAAG	0.577		NA											6	16					0	0	0	0
LMNB1	4001	broad.mit.edu	37	5	126154638	126154638	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr5:126154638C>G	uc003kud.1	+	6	1332	c.964C>G	c.(964-966)CAA>GAA	p.Q322E	LMNB1_uc003kuc.2_Missense_Mutation_p.Q322E|LMNB1_uc010jdb.1_RNA|LMNB1_uc011cxb.1_Missense_Mutation_p.Q112E	NM_005573	NP_005564	P20700	LMNB1_HUMAN	lamin B1	322	Rod.|Coil 2.				cellular component disassembly involved in apoptosis	lamin filament|nuclear inner membrane	protein binding|structural molecule activity			kidney(1)|central_nervous_system(1)	2		all_cancers(142;0.103)|Prostate(80;0.081)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	Epithelial(69;0.033)|OV - Ovarian serous cystadenocarcinoma(64;0.0398)|all cancers(49;0.0903)		GGAAAGGATTCAAGAATTAGA	0.388		NA											69	41					0	0	0	0
FBN2	2201	broad.mit.edu	37	5	127595187	127595187	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr5:127595187C>A	uc003kuu.2	-	65	9138	c.8699G>T	c.(8698-8700)GGG>GTG	p.G2900V		NM_001999	NP_001990	P35556	FBN2_HUMAN	fibrillin 2 precursor	2900					bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			ovary(8)|large_intestine(4)|pancreas(1)|kidney(1)|skin(1)	15		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		GAGAGCCTCCCCAAGCTCCCC	0.493		NA											62	44					9.54e-28	1.37e-27	1	0
FBN2	2201	broad.mit.edu	37	5	127702106	127702106	+	Missense_Mutation	SNP	A	A	T			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr5:127702106A>T	uc003kuu.2	-	17	2705	c.2266T>A	c.(2266-2268)TGT>AGT	p.C756S	FBN2_uc003kuv.2_Missense_Mutation_p.C723S	NM_001999	NP_001990	P35556	FBN2_HUMAN	fibrillin 2 precursor	756	TB 3.				bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			ovary(8)|large_intestine(4)|pancreas(1)|kidney(1)|skin(1)	15		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		CCACTACTACAAAGGCCGTGG	0.318		NA											19	16					0	0	0	0
TGFBI	7045	broad.mit.edu	37	5	135379745	135379745	+	Splice_Site	SNP	A	A	G			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr5:135379745A>G	uc003lbf.3	+	3	395	c.234_splice	c.e3-2	p.T78_splice	TGFBI_uc003lbg.3_Splice_Site|TGFBI_uc003lbh.3_Splice_Site|TGFBI_uc011cyb.1_5'Flank	NM_000358	NP_000349	Q15582	BGH3_HUMAN	transforming growth factor, beta-induced, 68kDa						angiogenesis|cell adhesion|cell proliferation|negative regulation of cell adhesion|response to stimulus|visual perception	extracellular space|proteinaceous extracellular matrix	integrin binding			breast(3)|ovary(1)	4			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			GTCTTGTTACAGAGTCATCAG	0.537		NA											95	51					0	0	0	0
TRPC7	57113	broad.mit.edu	37	5	135692763	135692763	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr5:135692763G>A	uc003lbn.1	-	1	313	c.310C>T	c.(310-312)CGG>TGG	p.R104W	TRPC7_uc010jef.1_Missense_Mutation_p.R96W|TRPC7_uc010jeg.1_RNA|TRPC7_uc010jeh.1_Missense_Mutation_p.R96W|TRPC7_uc010jei.1_Missense_Mutation_p.R96W|TRPC7_uc010jej.1_Translation_Start_Site	NM_020389	NP_065122	Q9HCX4	TRPC7_HUMAN	transient receptor potential cation channel,	105	Cytoplasmic (Potential).|ANK 2.				axon guidance|platelet activation	integral to membrane|plasma membrane	calcium channel activity|protein binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			TCCCCCACCCGTGCCAGGTTC	0.652		NA											37	21					0	0	0	0
PCDHA4	56144	broad.mit.edu	37	5	140188125	140188125	+	Silent	SNP	C	C	T			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr5:140188125C>T	uc003lhi.2	+	1	1454	c.1353C>T	c.(1351-1353)AAC>AAT	p.N451N	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhh.1_Silent_p.N451N|PCDHA4_uc011daa.1_Silent_p.N451N	NM_018907	NP_061730	Q9UN74	PCDA4_HUMAN	protocadherin alpha 4 isoform 1 precursor	451	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			ovary(4)|skin(2)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGAACGACAACGCTCCGGCGT	0.647		NA											62	28					0	0	0	0
PCDHA6	56142	broad.mit.edu	37	5	140209711	140209711	+	Missense_Mutation	SNP	T	T	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr5:140209711T>A	uc003lho.2	+	1	2062	c.2035T>A	c.(2035-2037)TCA>ACA	p.S679T	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc011dab.1_Missense_Mutation_p.S679T	NM_018909	NP_061732	Q9UN73	PCDA6_HUMAN	protocadherin alpha 6 isoform 1 precursor	679	Extracellular (Potential).				homophilic cell adhesion|nervous system development	extracellular region|integral to plasma membrane	calcium ion binding|protein binding			haematopoietic_and_lymphoid_tissue(1)|skin(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCCAAAGGCGTCATCACGGGC	0.677		NA											40	29					0	0	0	0
PCDHA10	56139	broad.mit.edu	37	5	140236619	140236619	+	Missense_Mutation	SNP	T	T	C			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr5:140236619T>C	uc003lhx.2	+	1	986	c.986T>C	c.(985-987)ATG>ACG	p.M329T	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Missense_Mutation_p.M329T|PCDHA10_uc011dad.1_Missense_Mutation_p.M329T	NM_018901	NP_061724	Q9Y5I2	PCDAA_HUMAN	protocadherin alpha 10 isoform 1 precursor	329	Cadherin 3.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	extracellular region|integral to plasma membrane	calcium ion binding|protein binding			ovary(2)|skin(2)|breast(1)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AACCCACCTATGGTTGGTCAC	0.408		NA											34	39					0	0	0	0
PCDHA10	56139	broad.mit.edu	37	5	140237225	140237225	+	Missense_Mutation	SNP	A	A	T			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr5:140237225A>T	uc003lhx.2	+	1	1592	c.1592A>T	c.(1591-1593)CAG>CTG	p.Q531L	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Missense_Mutation_p.Q531L|PCDHA10_uc011dad.1_Missense_Mutation_p.Q531L	NM_018901	NP_061724	Q9Y5I2	PCDAA_HUMAN	protocadherin alpha 10 isoform 1 precursor	531	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	extracellular region|integral to plasma membrane	calcium ion binding|protein binding			ovary(2)|skin(2)|breast(1)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GAGCTGCTACAGTTCCAGGTG	0.677		NA											80	49					0	0	0	0
PCDHA12	56137	broad.mit.edu	37	5	140256339	140256339	+	Silent	SNP	C	C	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr5:140256339C>A	uc003lic.2	+	1	1409	c.1282C>A	c.(1282-1284)CGG>AGG	p.R428R	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc003lia.2_Intron|PCDHA12_uc011daf.1_Silent_p.R428R	NM_018903	NP_061726	Q9UN75	PCDAC_HUMAN	protocadherin alpha 12 isoform 1 precursor	428	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGTGACTGCGCGGGATGGGGG	0.637		NA											124	76					1.16e-64	1.71e-64	1	0
PCDHB7	56129	broad.mit.edu	37	5	140554035	140554035	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr5:140554035C>T	uc003lit.2	+	1	1793	c.1619C>T	c.(1618-1620)GCG>GTG	p.A540V		NM_018940	NP_061763	Q9Y5E2	PCDB7_HUMAN	protocadherin beta 7 precursor	540	Extracellular (Potential).|Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|central_nervous_system(1)|skin(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GGCTCCCCCGCGCTGAGCAGC	0.697		NA											45	32					0	0	0	0
PCDHGA7	56108	broad.mit.edu	37	5	140762824	140762824	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr5:140762824G>T	uc003lka.1	+	1	358	c.358G>T	c.(358-360)GAC>TAC	p.D120Y	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003ljz.1_Missense_Mutation_p.D120Y	NM_018920	NP_061743	Q9Y5G6	PCDG7_HUMAN	protocadherin gamma subfamily A, 7 isoform 1	120	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TTACCCTATAGACGTGGAAAT	0.418		NA											60	37					7.51e-29	1.08e-28	1	0
PPP2R2B	5521	broad.mit.edu	37	5	146017900	146017900	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr5:146017900C>G	uc003loe.2	-	6	1229	c.704G>C	c.(703-705)TGC>TCC	p.C235S	PPP2R2B_uc010jgm.2_Missense_Mutation_p.C224S|PPP2R2B_uc003log.3_Missense_Mutation_p.C235S|PPP2R2B_uc003lof.3_Missense_Mutation_p.C235S|PPP2R2B_uc003loi.3_Missense_Mutation_p.C238S|PPP2R2B_uc003loh.3_Missense_Mutation_p.C235S|PPP2R2B_uc003loj.3_Missense_Mutation_p.C215S|PPP2R2B_uc003lok.3_Missense_Mutation_p.C224S|PPP2R2B_uc011dbu.1_Missense_Mutation_p.C241S|PPP2R2B_uc011dbv.1_Missense_Mutation_p.C293S	NM_004576	NP_004567	Q00005	2ABB_HUMAN	beta isoform of regulatory subunit B55, protein	235	WD 4.				apoptosis|signal transduction	cytoskeleton|mitochondrial outer membrane|protein phosphatase type 2A complex	protein binding|protein phosphatase type 2A regulator activity			ovary(1)|prostate(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			GAAGGTGTTGCAATGATGGGG	0.542		NA											43	21					0	0	0	0
NSD1	64324	broad.mit.edu	37	5	176637520	176637520	+	Nonsense_Mutation	SNP	C	C	G			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr5:176637520C>G	uc003mfr.3	+	5	2258	c.2120C>G	c.(2119-2121)TCA>TGA	p.S707*	NSD1_uc003mft.3_Nonsense_Mutation_p.S438*|NSD1_uc003mfs.1_Nonsense_Mutation_p.S604*|NSD1_uc011dfx.1_Nonsense_Mutation_p.S355*	NM_022455	NP_071900	Q96L73	NSD1_HUMAN	nuclear receptor binding SET domain protein 1	707					negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	androgen receptor binding|chromatin binding|estrogen receptor binding|histone methyltransferase activity (H3-K36 specific)|histone methyltransferase activity (H4-K20 specific)|ligand-dependent nuclear receptor binding|retinoid X receptor binding|thyroid hormone receptor binding|transcription corepressor activity|zinc ion binding			ovary(2)|kidney(1)	3	all_cancers(89;1.57e-05)|Renal(175;0.000269)|Lung NSC(126;0.00111)|all_lung(126;0.002)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)|Epithelial(233;0.198)	Kidney(146;0.235)		ATTAGTAACTCACATACAGAC	0.403		NA	T	NUP98	AML		Sotos Syndrome		Beckwith-Wiedemann_syndrome|Sotos_syndrome|Weaver_syndrome	HNSCC(47;0.14)			43	25					0	0	0	0
RNF182	221687	broad.mit.edu	37	6	13977639	13977639	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr6:13977639G>A	uc003nbe.2	+	3	707	c.289G>A	c.(289-291)GGG>AGG	p.G97R	RNF182_uc003nbf.2_Missense_Mutation_p.G97R|RNF182_uc003nbg.2_Missense_Mutation_p.G97R	NM_152737	NP_689950	Q8N6D2	RN182_HUMAN	ring finger protein 182	97						cytoplasm|integral to membrane|intracellular membrane-bounded organelle	protein binding|ubiquitin-protein ligase activity|zinc ion binding			large_intestine(2)|ovary(1)	3	Breast(50;0.00405)|Ovarian(93;0.0964)	all_hematologic(90;0.135)	Epithelial(50;0.195)			TGGAGGCAAAGGGAAGAAGTG	0.542		NA											58	84					0	0	0	0
GPLD1	2822	broad.mit.edu	37	6	24473885	24473885	+	Missense_Mutation	SNP	T	T	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr6:24473885T>A	uc003ned.1	-	6	563	c.452A>T	c.(451-453)CAC>CTC	p.H151L	GPLD1_uc010jpr.1_Intron|GPLD1_uc010jps.1_Missense_Mutation_p.H151L|GPLD1_uc003nee.2_Missense_Mutation_p.H151L	NM_001503	NP_001494	P80108	PHLD_HUMAN	glycosylphosphatidylinositol specific	151						extracellular region	glycosylphosphatidylinositol phospholipase D activity			ovary(2)|kidney(1)	3						ATAGGAGCCGTGAAAATCAAT	0.393		NA											22	15					0	0	0	0
SLC17A1	6568	broad.mit.edu	37	6	25830751	25830751	+	Splice_Site	SNP	C	C	T			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr6:25830751C>T	uc003nfh.3	-	2	150	c.34_splice	c.e2+1	p.V12_splice	SLC17A1_uc011djy.1_Intron|SLC17A1_uc010jqb.1_Splice_Site_p.V10_splice|SLC17A1_uc010jqc.1_Intron	NM_005074	NP_005065	Q14916	NPT1_HUMAN	solute carrier family 17 (sodium phosphate),						sodium ion transport|urate metabolic process	integral to plasma membrane|membrane fraction	sodium-dependent phosphate transmembrane transporter activity|symporter activity			ovary(3)|pancreas(1)	4						TAAAGTGCTACCTTTTTTGGG	0.398		NA											66	73					0	0	0	0
HIST1H3D	8351	broad.mit.edu	37	6	26197203	26197203	+	Silent	SNP	C	C	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr6:26197203C>A	uc003ngv.2	-	2	673	c.276G>T	c.(274-276)GCG>GCT	p.A92A	HIST1H2BF_uc003ngx.2_5'Flank	NM_003530	NP_003521	P68431	H31_HUMAN	histone cluster 1, H3d	92					blood coagulation|nucleosome assembly|regulation of gene silencing|S phase	nucleoplasm|nucleosome	DNA binding|protein binding				0		all_hematologic(11;0.196)				CCTCCTGCAGCGCCATCACCG	0.587		NA											31	99					2.08e-15	2.82e-15	1	0
HIST1H1B	3009	broad.mit.edu	37	6	27835170	27835170	+	Silent	SNP	C	C	T			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr6:27835170C>T	uc003njx.2	-	1	190	c.138G>A	c.(136-138)CTG>CTA	p.L46L		NM_005322	NP_005313	P16401	H15_HUMAN	histone cluster 1, H1b	46	H15.				nucleosome assembly	nucleosome|nucleus	DNA binding			large_intestine(2)|lung(1)	3						CCTTGGTGATCAGCTCTGAGA	0.602		NA											25	87					0	0	0	0
OR11A1	26531	broad.mit.edu	37	6	29394860	29394860	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr6:29394860C>A	uc003nmg.2	-	1	650	c.559G>T	c.(559-561)GGC>TGC	p.G187C		NM_013937	NP_039225	Q9GZK7	O11A1_HUMAN	olfactory receptor, family 11, subfamily A,	187	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						CAAGCCAGGCCCACGAAAAGC	0.507		NA											21	14					2.89e-11	3.7e-11	1	0
DNAH8	1769	broad.mit.edu	37	6	38905924	38905924	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr6:38905924C>A	uc003ooe.1	+	76	11687	c.11087C>A	c.(11086-11088)ACA>AAA	p.T3696K	DNAH8_uc003oog.1_Missense_Mutation_p.T145K|uc003oof.1_Intron	NM_001371	NP_001362			dynein, axonemal, heavy polypeptide 8											skin(8)|ovary(7)|lung(2)|large_intestine(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	21						TTCCTCATCACAGAGATGAGC	0.522		NA											52	25					1.21e-23	1.72e-23	1	0
DAAM2	23500	broad.mit.edu	37	6	39864638	39864638	+	Missense_Mutation	SNP	A	A	T			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr6:39864638A>T	uc003oow.2	+	20	2548	c.2392A>T	c.(2392-2394)ATG>TTG	p.M798L	DAAM2_uc003oox.2_Missense_Mutation_p.M798L	NM_015345	NP_056160	Q86T65	DAAM2_HUMAN	dishevelled associated activator of	798	FH2.				actin cytoskeleton organization		actin binding|Rho GTPase binding			ovary(2)|skin(1)	3	Ovarian(28;0.0355)|Colorectal(47;0.196)					TCTTAGACAGATGCTAGAGGT	0.622		NA											18	8					0	0	0	0
CUL9	23113	broad.mit.edu	37	6	43170895	43170895	+	Missense_Mutation	SNP	A	A	G			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr6:43170895A>G	uc003ouk.2	+	18	3877	c.3802A>G	c.(3802-3804)AAC>GAC	p.N1268D	CUL9_uc003oul.2_Missense_Mutation_p.N1268D|CUL9_uc010jyk.2_Missense_Mutation_p.N420D	NM_015089	NP_055904	Q8IWT3	CUL9_HUMAN	p53-associated parkin-like cytoplasmic protein	1268	DOC.			N -> S (in Ref. 3; CAH18328).	ubiquitin-dependent protein catabolic process	cullin-RING ubiquitin ligase complex|cytoplasm	ATP binding|ubiquitin protein ligase binding|zinc ion binding			ovary(5)|lung(3)|skin(2)|breast(1)|central_nervous_system(1)	12						GGAGAACCTGAACCGCTTCTG	0.577		NA											23	28					0	0	0	0
HMGCLL1	54511	broad.mit.edu	37	6	55443753	55443753	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr6:55443753G>T	uc003pcn.2	-	1	260	c.101C>A	c.(100-102)CCC>CAC	p.P34H	HMGCLL1_uc003pco.2_Missense_Mutation_p.P34H|HMGCLL1_uc010jzx.2_5'UTR|HMGCLL1_uc011dxc.1_Missense_Mutation_p.P34H|HMGCLL1_uc011dxd.1_Missense_Mutation_p.P34H|HMGCLL1_uc011dxe.1_Missense_Mutation_p.P34H|HMGCLL1_uc003pcp.2_Missense_Mutation_p.P34H	NM_019036	NP_061909	Q8TB92	HMGC2_HUMAN	3-hydroxymethyl-3-methylglutaryl-Coenzyme A	34							hydroxymethylglutaryl-CoA lyase activity|metal ion binding			skin(2)|ovary(1)|pancreas(1)	4	Lung NSC(77;0.0875)		LUSC - Lung squamous cell carcinoma(124;0.23)			TACCTGCGCGGGGTCGAGCGC	0.647		NA											5	3					1.02e-07	1.23e-07	1	0
BAI3	577	broad.mit.edu	37	6	69666697	69666697	+	Nonsense_Mutation	SNP	C	C	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr6:69666697C>A	uc003pev.3	+	8	1969	c.1521C>A	c.(1519-1521)TGC>TGA	p.C507*	BAI3_uc010kak.2_Nonsense_Mutation_p.C507*	NM_001704	NP_001695	O60242	BAI3_HUMAN	brain-specific angiogenesis inhibitor 3	507	TSP type-1 4.|Extracellular (Potential).				negative regulation of angiogenesis|neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			lung(27)|ovary(8)|skin(6)|pancreas(4)|central_nervous_system(3)|urinary_tract(1)|breast(1)	50		all_lung(197;0.212)				AGCAGCGATGCCCTGGTGAGA	0.423		NA											39	30					1.5e-21	2.1e-21	1	0
TBX18	9096	broad.mit.edu	37	6	85446515	85446515	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr6:85446515G>T	uc003pkl.1	-	8	1712	c.1712C>A	c.(1711-1713)CCT>CAT	p.P571H	TBX18_uc010kbq.1_Intron	NM_001080508	NP_001073977	O95935	TBX18_HUMAN	T-box 18	571					multicellular organismal development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(2)|pancreas(2)|lung(1)	5		all_cancers(76;0.000283)|Acute lymphoblastic leukemia(125;3.66e-08)|all_hematologic(105;8.61e-05)|all_epithelial(107;0.0858)		BRCA - Breast invasive adenocarcinoma(108;0.0267)		TCCTTCCACAGGGGGCAACAT	0.522		NA											40	18					4.05e-12	5.27e-12	1	0
GPR63	81491	broad.mit.edu	37	6	97246760	97246760	+	Missense_Mutation	SNP	A	A	G			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr6:97246760A>G	uc010kcl.2	-	3	1326	c.848T>C	c.(847-849)ATA>ACA	p.I283T	GPR63_uc003pou.2_Missense_Mutation_p.I283T	NM_001143957	NP_001137429	Q9BZJ6	GPR63_HUMAN	G protein-coupled receptor 63	283	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity|protein binding			upper_aerodigestive_tract(1)|ovary(1)	2		all_cancers(76;6.89e-05)|Acute lymphoblastic leukemia(125;7.02e-10)|all_hematologic(75;1.23e-06)|all_epithelial(107;0.0618)|Colorectal(196;0.0721)		BRCA - Breast invasive adenocarcinoma(108;0.0912)		GCTGAGGCATATACCTTCAGG	0.473		NA											47	24					0	0	0	0
PRDM1	639	broad.mit.edu	37	6	106547326	106547326	+	Missense_Mutation	SNP	A	A	T			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr6:106547326A>T	uc003prd.2	+	4	797	c.563A>T	c.(562-564)AAG>ATG	p.K188M	PRDM1_uc003pre.2_Missense_Mutation_p.K54M	NM_001198	NP_001189	O75626	PRDM1_HUMAN	PR domain containing 1, with ZNF domain isoform	188	SET.				negative regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(54)|ovary(1)|skin(1)	56	Breast(9;0.022)	all_cancers(87;2.2e-31)|all_epithelial(87;2.03e-21)|Acute lymphoblastic leukemia(125;4.99e-11)|all_lung(197;7.55e-09)|all_hematologic(75;5.82e-08)|Lung NSC(302;1.28e-06)|Colorectal(196;0.0112)|Ovarian(999;0.0365)		all cancers(137;1.83e-46)|Epithelial(106;5.59e-35)|OV - Ovarian serous cystadenocarcinoma(136;1.99e-20)|GBM - Glioblastoma multiforme(226;3.72e-11)|BRCA - Breast invasive adenocarcinoma(108;1.38e-05)		TACACCATTAAGCCCATCCCT	0.502		NA	D|N|Mis|F|S		DLBCL								27	30					0	0	0	0
GPRC6A	222545	broad.mit.edu	37	6	117127963	117127963	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr6:117127963C>A	uc003pxj.1	-	3	927	c.905G>T	c.(904-906)AGT>ATT	p.S302I	GPRC6A_uc003pxk.1_Intron|GPRC6A_uc003pxl.1_Missense_Mutation_p.S302I	NM_148963	NP_683766	Q5T6X5	GPC6A_HUMAN	G protein-coupled receptor, family C, group 6,	302	Extracellular (Potential).				response to amino acid stimulus		G-protein coupled receptor activity			ovary(4)|skin(2)	6		all_cancers(87;0.0314)|all_epithelial(87;0.0216)|Colorectal(196;0.234)		GBM - Glioblastoma multiforme(226;0.0265)|all cancers(137;0.0554)|OV - Ovarian serous cystadenocarcinoma(136;0.07)		CCAATTATCACTAGCAATCCA	0.363		NA											44	41					9.39e-22	1.32e-21	1	0
ENPP3	5169	broad.mit.edu	37	6	132043384	132043384	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr6:132043384C>A	uc003qcu.3	+	19	1932	c.1585C>A	c.(1585-1587)CCA>ACA	p.P529T	ENPP3_uc010kfq.2_RNA|ENPP3_uc003qcv.2_Missense_Mutation_p.P529T	NM_005021	NP_005012	O14638	ENPP3_HUMAN	ectonucleotide pyrophosphatase/phosphodiesterase	529	Extracellular (Potential).				immune response|nucleoside triphosphate catabolic process|phosphate metabolic process	extracellular region|integral to plasma membrane|perinuclear region of cytoplasm	metal ion binding|nucleic acid binding|nucleoside-triphosphate diphosphatase activity|nucleotide diphosphatase activity|phosphodiesterase I activity|polysaccharide binding|scavenger receptor activity			ovary(3)|skin(1)	4	Breast(56;0.0753)			GBM - Glioblastoma multiforme(226;0.0252)|OV - Ovarian serous cystadenocarcinoma(155;0.0511)		ACGCATTCAACCAGCACCAAA	0.408		NA											29	23					3.67e-24	5.22e-24	1	0
TAAR9	134860	broad.mit.edu	37	6	132859539	132859539	+	Silent	SNP	C	C	T			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr6:132859539C>T	uc011eci.1	+	1	113	c.111C>T	c.(109-111)GCC>GCT	p.A37A		NM_175057	NP_778227	Q96RI9	TAAR9_HUMAN	trace amine associated receptor 9	37	Extracellular (Potential).					plasma membrane	G-protein coupled receptor activity				0	Breast(56;0.112)			OV - Ovarian serous cystadenocarcinoma(155;0.0042)|GBM - Glioblastoma multiforme(226;0.00816)		TCCTCTACGCCGTCCTTGGTT	0.478		NA											33	17					0	0	0	0
GRM1	2911	broad.mit.edu	37	6	146755793	146755793	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr6:146755793C>T	uc010khw.1	+	9	3916	c.3446C>T	c.(3445-3447)TCG>TTG	p.S1149L	GRM1_uc010khv.1_3'UTR|GRM1_uc003qll.2_3'UTR|GRM1_uc011edz.1_3'UTR|GRM1_uc011eea.1_3'UTR	NM_000838	NP_000829	Q13255	GRM1_HUMAN	glutamate receptor, metabotropic 1 isoform alpha	1149	Ser-rich.|Cytoplasmic (Potential).				synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			lung(8)|ovary(4)|central_nervous_system(3)|large_intestine(2)|breast(2)	19		Ovarian(120;0.0387)		OV - Ovarian serous cystadenocarcinoma(155;5.35e-08)|GBM - Glioblastoma multiforme(68;0.00762)	Acamprosate(DB00659)|L-Glutamic Acid(DB00142)	ACGCCTCCGTCGCCTTTCCGC	0.657		NA											5	43					0	0	0	0
SASH1	23328	broad.mit.edu	37	6	148867161	148867161	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr6:148867161G>T	uc003qme.1	+	19	3834	c.3359G>T	c.(3358-3360)TGT>TTT	p.C1120F	SASH1_uc003qmf.1_Missense_Mutation_p.C530F	NM_015278	NP_056093	O94885	SASH1_HUMAN	SAM and SH3 domain containing 1	1120							protein binding			central_nervous_system(1)	1		Ovarian(120;0.0169)		OV - Ovarian serous cystadenocarcinoma(155;5.63e-11)|GBM - Glioblastoma multiforme(68;0.0701)		CATGGCCGCTGTGGGATTCCT	0.498		NA											39	19					1.75e-18	2.41e-18	1	0
LATS1	9113	broad.mit.edu	37	6	150005102	150005102	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr6:150005102G>A	uc003qmu.1	-	4	1671	c.1123C>T	c.(1123-1125)CCA>TCA	p.P375S	LATS1_uc010kif.1_Missense_Mutation_p.P270S|LATS1_uc003qmv.1_Missense_Mutation_p.P375S|LATS1_uc003qmw.2_Missense_Mutation_p.P375S|LATS1_uc010kig.1_Missense_Mutation_p.P270S	NM_004690	NP_004681	O95835	LATS1_HUMAN	LATS homolog 1	375	PPxY motif 1.				cell division|cytoplasmic sequestering of protein|G2/M transition of mitotic cell cycle|hippo signaling cascade|hormone-mediated signaling pathway|mitosis|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cyclin-dependent protein kinase activity|positive regulation of peptidyl-serine phosphorylation|regulation of actin filament polymerization|sister chromatid segregation	microtubule organizing center|spindle pole	ATP binding|magnesium ion binding|protein kinase binding|protein serine/threonine kinase activity			lung(5)|central_nervous_system(1)	6		Ovarian(120;0.0164)		OV - Ovarian serous cystadenocarcinoma(155;6.93e-13)|GBM - Glioblastoma multiforme(68;0.116)		AGAGGATATGGAGGTGGTGGC	0.478		NA											40	30					0	0	0	0
SYNE1	23345	broad.mit.edu	37	6	152605236	152605236	+	Silent	SNP	C	C	G			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr6:152605236C>G	uc010kiw.2	-	96	18686	c.18084G>C	c.(18082-18084)CTG>CTC	p.L6028L	SYNE1_uc010kiv.2_Silent_p.L552L|SYNE1_uc003qos.3_Silent_p.L552L|SYNE1_uc003qot.3_Silent_p.L5957L|SYNE1_uc003qou.3_Silent_p.L6028L|SYNE1_uc010kiy.1_Silent_p.L207L	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	6028	Spectrin 20.|Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		ACTCGGATACCAGCTCCTCTG	0.542		NA								HNSCC(10;0.0054)			35	25					0	0	0	0
SYNE1	23345	broad.mit.edu	37	6	152631122	152631122	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr6:152631122G>A	uc010kiw.2	-	90	17652	c.17050C>T	c.(17050-17052)CCG>TCG	p.P5684S	SYNE1_uc010kiv.2_Missense_Mutation_p.P208S|SYNE1_uc003qos.3_Missense_Mutation_p.P208S|SYNE1_uc003qot.3_Missense_Mutation_p.P5613S|SYNE1_uc003qou.3_Missense_Mutation_p.P5684S	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	5684	Spectrin 18.|Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		TGCACCTTCGGCTTCAGTGAC	0.448		NA								HNSCC(10;0.0054)			30	19					0	0	0	0
VIP	7432	broad.mit.edu	37	6	153077303	153077303	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr6:153077303C>A	uc003qpe.2	+	5	542	c.370C>A	c.(370-372)CGT>AGT	p.R124S	VIP_uc003qpf.2_Missense_Mutation_p.R123S|VIP_uc010kjd.2_Missense_Mutation_p.R123S	NM_003381	NP_003372	P01282	VIP_HUMAN	vasoactive intestinal peptide isoform 1	124					body fluid secretion|G-protein coupled receptor protein signaling pathway|positive regulation of cell proliferation	extracellular region	neuropeptide hormone activity				0		Ovarian(120;0.0654)		OV - Ovarian serous cystadenocarcinoma(155;4.5e-11)|BRCA - Breast invasive adenocarcinoma(81;0.144)		ACCAGTCAAACGTCACTCAGA	0.383		NA											67	43					1.93e-29	2.79e-29	1	0
SLC22A2	6582	broad.mit.edu	37	6	160668217	160668217	+	Missense_Mutation	SNP	T	T	G			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr6:160668217T>G	uc003qtf.2	-	5	1126	c.956A>C	c.(955-957)CAG>CCG	p.Q319P	SLC22A2_uc003qte.1_Missense_Mutation_p.Q319P	NM_003058	NP_003049	O15244	S22A2_HUMAN	solute carrier family 22 member 2	319	Cytoplasmic (Potential).				body fluid secretion|neurotransmitter biosynthetic process|neurotransmitter secretion	integral to plasma membrane|membrane fraction	neurotransmitter transporter activity|organic cation transmembrane transporter activity			breast(1)|skin(1)	2		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;2.28e-17)|BRCA - Breast invasive adenocarcinoma(81;6.29e-06)		CTGGCTCACCTGAAGGGAGGC	0.488		NA											50	27					0	0	0	0
MAD1L1	8379	broad.mit.edu	37	7	1937853	1937853	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr7:1937853C>T	uc003slh.1	-	18	2247	c.1981G>A	c.(1981-1983)GAC>AAC	p.D661N	MAD1L1_uc003sle.1_Missense_Mutation_p.D390N|MAD1L1_uc003slf.1_Missense_Mutation_p.D661N|MAD1L1_uc003slg.1_Missense_Mutation_p.D661N|MAD1L1_uc010ksh.1_Missense_Mutation_p.D661N|MAD1L1_uc003sli.1_Missense_Mutation_p.D569N|MAD1L1_uc010ksi.1_Missense_Mutation_p.D614N|MAD1L1_uc010ksj.2_Missense_Mutation_p.D661N|MAD1L1_uc003sld.1_Missense_Mutation_p.D117N	NM_001013836	NP_001013858	Q9Y6D9	MD1L1_HUMAN	MAD1-like 1 protein	661					cell division|mitotic anaphase|mitotic cell cycle spindle assembly checkpoint|mitotic metaphase|mitotic prometaphase|mitotic telophase	actin cytoskeleton|centrosome|condensed chromosome kinetochore|cytosol|mitochondrion|nucleus|spindle	protein binding			lung(1)|central_nervous_system(1)	2		Ovarian(82;0.0272)		UCEC - Uterine corpus endometrioid carcinoma (27;0.134)|OV - Ovarian serous cystadenocarcinoma(56;3.63e-14)		ATGAGGCAGTCGCCTGGGTGC	0.627		NA											4	9					0	0	0	0
DGKB	1607	broad.mit.edu	37	7	14722240	14722240	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr7:14722240G>T	uc003ssz.2	-	11	1160	c.973C>A	c.(973-975)CAC>AAC	p.H325N	DGKB_uc011jxt.1_Missense_Mutation_p.H318N|DGKB_uc003sta.2_Missense_Mutation_p.H325N|DGKB_uc011jxu.1_Missense_Mutation_p.H325N	NM_004080	NP_004071	Q9Y6T7	DGKB_HUMAN	diacylglycerol kinase, beta isoform 1	325	Phorbol-ester/DAG-type 2.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	cytoplasm|plasma membrane	ATP binding|calcium ion binding|diacylglycerol kinase activity|protein binding			lung(5)|ovary(4)|breast(2)|skin(1)	12					Phosphatidylserine(DB00144)	ACAGTTTTGTGGCACTTATCA	0.423		NA											40	93					1.49e-12	1.95e-12	1	0
PRPS1L1	221823	broad.mit.edu	37	7	18067285	18067285	+	Missense_Mutation	SNP	A	A	T			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr7:18067285A>T	uc003stz.2	-	1	202	c.121T>A	c.(121-123)TGC>AGC	p.C41S		NM_175886	NP_787082	P21108	PRPS3_HUMAN	phosphoribosyl pyrophosphate synthetase 1-like	41					nucleoside metabolic process|ribonucleoside monophosphate biosynthetic process		ATP binding|kinase activity|magnesium ion binding|protein homodimerization activity|ribose phosphate diphosphokinase activity			ovary(1)	1	Lung NSC(10;0.0385)|all_lung(11;0.0736)					ATTTCCACGCAGGTCTCCTGG	0.512		NA											65	138					0	0	0	0
CRHR2	1395	broad.mit.edu	37	7	30706845	30706845	+	Missense_Mutation	SNP	T	T	C			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr7:30706845T>C	uc003tbn.2	-	3	558	c.314A>G	c.(313-315)AAG>AGG	p.K105R	CRHR2_uc010kvw.1_Missense_Mutation_p.K105R|CRHR2_uc010kvx.1_Missense_Mutation_p.K105R|CRHR2_uc010kvy.1_Intron|CRHR2_uc003tbo.2_Missense_Mutation_p.K91R|CRHR2_uc003tbp.2_Missense_Mutation_p.K132R	NM_001883	NP_001874	Q13324	CRFR2_HUMAN	corticotropin releasing hormone receptor 2	105	Extracellular (Potential).				G-protein signaling, coupled to cAMP nucleotide second messenger	integral to plasma membrane	corticotrophin-releasing factor receptor activity|protein binding			lung(2)|ovary(1)|skin(1)	4						GCCACTCACCTTGTCATCCAA	0.517		NA											15	47					0	0	0	0
CCDC129	223075	broad.mit.edu	37	7	31683113	31683113	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr7:31683113C>T	uc003tcj.1	+	11	3122	c.2129C>T	c.(2128-2130)ACC>ATC	p.T710I	CCDC129_uc011kad.1_Missense_Mutation_p.T720I|CCDC129_uc003tci.1_Missense_Mutation_p.T561I|CCDC129_uc011kae.1_Missense_Mutation_p.T736I|CCDC129_uc003tck.1_Missense_Mutation_p.T618I	NM_194300	NP_919276	Q6ZRS4	CC129_HUMAN	coiled-coil domain containing 129	710											0						TCTGTAATGACCCAGATGTCC	0.522		NA											25	45					0	0	0	0
PDE1C	5137	broad.mit.edu	37	7	32209472	32209472	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr7:32209472C>A	uc003tco.1	-	3	827	c.233G>T	c.(232-234)CGA>CTA	p.R78L		NM_005020	NP_005011	Q14123	PDE1C_HUMAN	phosphodiesterase 1C	Error:Variant_position_missing_in_Q14123_after_alignment					activation of phospholipase C activity|nerve growth factor receptor signaling pathway	cytosol	calmodulin binding|calmodulin-dependent cyclic-nucleotide phosphodiesterase activity|metal ion binding			skin(3)|central_nervous_system(1)	4			GBM - Glioblastoma multiforme(11;0.216)			CTCTGGGGGTCGAGGGTCATG	0.507		NA											29	64					1.05e-18	1.44e-18	1	0
NPSR1	387129	broad.mit.edu	37	7	34889223	34889223	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr7:34889223G>A	uc003teg.1	+	9	1200	c.1072G>A	c.(1072-1074)GAG>AAG	p.E358K	AAA1_uc010kwq.1_Intron|AAA1_uc011kaq.1_Intron|NPSR1_uc003teh.1_Silent_p.*391*|NPSR1_uc010kwt.1_Missense_Mutation_p.E205K|NPSR1_uc010kwu.1_Missense_Mutation_p.E148K|NPSR1_uc010kwv.1_Missense_Mutation_p.E292K|NPSR1_uc003tei.1_Intron|NPSR1_uc010kww.1_Intron|NPSR1_uc011kar.1_Intron	NM_207172	NP_997055	Q6W5P4	NPSR1_HUMAN	G protein-coupled receptor for asthma	358	Cytoplasmic (Potential).					cytoplasm|integral to membrane|plasma membrane	vasopressin receptor activity			skin(3)|pancreas(1)	4					Halothane(DB01159)	GGAGAGAACTGAGAGGCATGA	0.488		NA											40	80					0	0	0	0
TXNDC3	51314	broad.mit.edu	37	7	37903952	37903952	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr7:37903952G>A	uc003tfn.2	+	9	829	c.457G>A	c.(457-459)GAA>AAA	p.E153K		NM_016616	NP_057700	Q8N427	TXND3_HUMAN	thioredoxin domain containing 3	153					cell differentiation|cell redox homeostasis|CTP biosynthetic process|GTP biosynthetic process|multicellular organismal development|spermatogenesis|UTP biosynthetic process	cytoplasm|microtubule cytoskeleton	ATP binding|nucleoside diphosphate kinase activity			ovary(1)|breast(1)|central_nervous_system(1)	3						TTTTCCAGAGGAATTATACAG	0.284		NA							Kartagener_syndrome				12	24					0	0	0	0
ADCY1	107	broad.mit.edu	37	7	45697343	45697343	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr7:45697343C>A	uc003tne.3	+	6	1184	c.1166C>A	c.(1165-1167)ACC>AAC	p.T389N	ADCY1_uc003tnd.2_Missense_Mutation_p.T164N	NM_021116	NP_066939	Q08828	ADCY1_HUMAN	adenylate cyclase 1	389	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|calmodulin binding|metal ion binding			ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	6					Adenosine(DB00640)|Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)	GCTGAAGCCACCGAGGTGGAT	0.607		NA											5	15					1.24e-05	1.4e-05	1	0
TNS3	64759	broad.mit.edu	37	7	47333420	47333420	+	Missense_Mutation	SNP	T	T	C			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr7:47333420T>C	uc003tnv.2	-	25	4050	c.3683A>G	c.(3682-3684)GAT>GGT	p.D1228G	TNS3_uc003tnw.2_Missense_Mutation_p.D1228G	NM_022748	NP_073585	Q68CZ2	TENS3_HUMAN	tensin 3	1228	SH2.					focal adhesion	protein binding			ovary(4)	4						ATTGGCCAAATCTCCAGCTGT	0.438		NA											28	50					0	0	0	0
TNS3	64759	broad.mit.edu	37	7	47408232	47408232	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr7:47408232C>T	uc003tnv.2	-	17	2378	c.2011G>A	c.(2011-2013)GGA>AGA	p.G671R	TNS3_uc003tnw.2_Missense_Mutation_p.G671R	NM_022748	NP_073585	Q68CZ2	TENS3_HUMAN	tensin 3	671						focal adhesion	protein binding			ovary(4)	4						ACCTGGTCTCCTGGAAACCTG	0.632		NA											60	113					0	0	0	0
PKD1L1	168507	broad.mit.edu	37	7	47894539	47894539	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr7:47894539C>G	uc003tny.1	-	30	4800	c.4800G>C	c.(4798-4800)CAG>CAC	p.Q1600H		NM_138295	NP_612152	Q8TDX9	PK1L1_HUMAN	polycystin-1L1	1600	Extracellular (Potential).				cell-cell adhesion	integral to membrane				ovary(8)|upper_aerodigestive_tract(2)|breast(1)	11						CAATTTCTATCTGTAGAGATT	0.398		NA											31	63					0	0	0	0
ABCA13	154664	broad.mit.edu	37	7	48285513	48285513	+	Silent	SNP	C	C	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr7:48285513C>A	uc003toq.2	+	13	1570	c.1545C>A	c.(1543-1545)GTC>GTA	p.V515V	ABCA13_uc010kyr.2_Silent_p.V18V	NM_152701	NP_689914	Q86UQ4	ABCAD_HUMAN	ATP binding cassette, sub-family A (ABC1),	515					transport	integral to membrane	ATP binding|ATPase activity			ovary(5)|central_nervous_system(4)|skin(1)	10						AGAAGGAGGTCTTTTTGCCGC	0.448		NA											15	37					6.72e-11	8.57e-11	1	0
ABCA13	154664	broad.mit.edu	37	7	48318403	48318403	+	Missense_Mutation	SNP	A	A	T			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr7:48318403A>T	uc003toq.2	+	18	7637	c.7612A>T	c.(7612-7614)ACA>TCA	p.T2538S	ABCA13_uc010kys.1_5'Flank	NM_152701	NP_689914	Q86UQ4	ABCAD_HUMAN	ATP binding cassette, sub-family A (ABC1),	2538					transport	integral to membrane	ATP binding|ATPase activity			ovary(5)|central_nervous_system(4)|skin(1)	10						GAAGATGTCCACAGTTTTTAA	0.393		NA											55	134					0	0	0	0
ZPBP	11055	broad.mit.edu	37	7	50129302	50129302	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr7:50129302C>G	uc003tou.2	-	2	201	c.131G>C	c.(130-132)GGA>GCA	p.G44A	ZPBP_uc010kyw.2_Missense_Mutation_p.G44A	NM_007009	NP_008940	Q9BS86	ZPBP1_HUMAN	zona pellucida binding protein isoform 1	44					binding of sperm to zona pellucida	extracellular region					0	Glioma(55;0.08)|all_neural(89;0.245)					AACCAAGTGTCCAACTATCAA	0.318		NA											16	22					0	0	0	0
GTF2I	2969	broad.mit.edu	37	7	74113421	74113421	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr7:74113421C>G	uc003uau.2	+	4	739	c.369C>G	c.(367-369)TGC>TGG	p.C123W	GTF2I_uc003uat.2_Missense_Mutation_p.C123W|GTF2I_uc003uav.2_Missense_Mutation_p.C123W|GTF2I_uc003uaw.2_Missense_Mutation_p.C123W|GTF2I_uc003uay.2_Missense_Mutation_p.C123W|GTF2I_uc003uax.2_Missense_Mutation_p.C123W	NM_032999	NP_127492	P78347	GTF2I_HUMAN	general transcription factor IIi isoform 1	123	GTF2I-like 1.				negative regulation of angiogenesis|signal transduction|transcription initiation from RNA polymerase II promoter	cytoplasm|nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity				0						TCTGCTTTTGCTATGGTAAAA	0.294		NA											7	23					0	0	0	0
PHTF2	57157	broad.mit.edu	37	7	77569410	77569410	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr7:77569410G>A	uc003ugs.3	+	13	1657	c.1531G>A	c.(1531-1533)GGT>AGT	p.G511S	PHTF2_uc003ugp.2_Missense_Mutation_p.G473S|PHTF2_uc003ugq.3_Missense_Mutation_p.G473S|PHTF2_uc010ldv.2_Missense_Mutation_p.G473S|PHTF2_uc003ugt.3_Missense_Mutation_p.G477S|PHTF2_uc003ugu.3_Missense_Mutation_p.G473S|PHTF2_uc010ldw.1_Missense_Mutation_p.G293S	NM_001127357	NP_001120829	Q8N3S3	PHTF2_HUMAN	putative homeodomain transcription factor 2	511					regulation of transcription, DNA-dependent|transcription, DNA-dependent	endoplasmic reticulum|nucleus	DNA binding			ovary(1)	1						TCTCATACTGGGTTTAACTCC	0.408		NA											21	59					0	0	0	0
PCLO	27445	broad.mit.edu	37	7	82538271	82538271	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr7:82538271C>A	uc003uhx.2	-	8	13648	c.13359G>T	c.(13357-13359)TTG>TTT	p.L4453F	PCLO_uc003uhv.2_Missense_Mutation_p.L4453F	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	4384					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						GTCCATTTTCCAAACGAGACT	0.443		NA											22	58					2.38e-13	3.13e-13	1	0
CDK14	5218	broad.mit.edu	37	7	90419960	90419960	+	Silent	SNP	C	C	T			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr7:90419960C>T	uc003uky.2	+	5	759	c.537C>T	c.(535-537)ATC>ATT	p.I179I	CDK14_uc003ukt.1_Silent_p.I133I|CDK14_uc003ukv.1_Silent_p.I133I|CDK14_uc003uku.1_Silent_p.I133I|CDK14_uc003ukx.1_RNA|CDK14_uc003ukz.1_Silent_p.I161I|CDK14_uc010les.1_Silent_p.I133I|CDK14_uc011khl.1_Silent_p.I50I	NM_012395	NP_036527	O94921	CDK14_HUMAN	PFTAIRE protein kinase 1	179	Protein kinase.				cell division|G2/M transition of mitotic cell cycle|regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	cytoplasmic cyclin-dependent protein kinase holoenzyme complex|nucleus|plasma membrane	ATP binding|cyclin binding|cyclin-dependent protein kinase activity			lung(3)|ovary(1)	4						TCACAGCTATCAGGGAAGGTA	0.403		NA											15	32					0	0	0	0
CASD1	64921	broad.mit.edu	37	7	94183816	94183816	+	Missense_Mutation	SNP	A	A	G			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr7:94183816A>G	uc003uni.3	+	17	2283	c.2056A>G	c.(2056-2058)AGA>GGA	p.R686G	CASD1_uc003unj.3_Missense_Mutation_p.R686G	NM_022900	NP_075051	Q96PB1	CASD1_HUMAN	CAS1 domain containing 1 precursor	686	Helical; (Potential).					integral to membrane				ovary(2)	2	all_cancers(62;6.71e-10)|all_epithelial(64;5e-09)|Lung NSC(181;0.188)|all_lung(186;0.215)		STAD - Stomach adenocarcinoma(171;0.0031)			CATCCTAATAAGAAACATCCC	0.274		NA											24	59					0	0	0	0
PPP1R9A	55607	broad.mit.edu	37	7	94740690	94740690	+	Silent	SNP	G	G	T			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr7:94740690G>T	uc003unp.2	+	3	1797	c.1515G>T	c.(1513-1515)GTG>GTT	p.V505V	PPP1R9A_uc010lfj.2_Silent_p.V505V|PPP1R9A_uc011kif.1_Silent_p.V505V|PPP1R9A_uc003unq.2_Silent_p.V505V|PPP1R9A_uc011kig.1_Silent_p.V505V	NM_017650	NP_060120	Q9ULJ8	NEB1_HUMAN	protein phosphatase 1, regulatory (inhibitor)	505	PDZ.					cell junction|synapse|synaptosome	actin binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	4	all_cancers(62;9.12e-11)|all_epithelial(64;4.34e-09)		STAD - Stomach adenocarcinoma(171;0.0031)			TTTTCCCAGTGGAGCTAGAGA	0.373		NA								HNSCC(28;0.073)			23	46					2.32e-17	3.19e-17	1	0
PUS7	54517	broad.mit.edu	37	7	105111200	105111200	+	Nonsense_Mutation	SNP	C	C	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr7:105111200C>A	uc003vcx.2	-	11	1552	c.1333G>T	c.(1333-1335)GAA>TAA	p.E445*	PUS7_uc010lji.2_Nonsense_Mutation_p.E451*|PUS7_uc003vcy.2_Nonsense_Mutation_p.E445*|PUS7_uc003vcz.1_Nonsense_Mutation_p.E445*	NM_019042	NP_061915	Q96PZ0	PUS7_HUMAN	pseudouridylate synthase 7 homolog	445	TRUD.				pseudouridine synthesis|tRNA processing		pseudouridine synthase activity|RNA binding			breast(1)	1						AGCTGCCCTTCCACACACCTT	0.453		NA											56	89					2.17e-26	3.11e-26	1	0
CFTR	1080	broad.mit.edu	37	7	117267811	117267811	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr7:117267811G>T	uc003vjd.2	+	22	3836	c.3704G>T	c.(3703-3705)AGT>ATT	p.S1235I	CFTR_uc011knq.1_Missense_Mutation_p.S641I	NM_000492	NP_000483	P13569	CFTR_HUMAN	cystic fibrosis transmembrane conductance	1235	Cytoplasmic (Potential).|ABC transporter 2.		S -> R (in CF).		respiratory gaseous exchange	apical plasma membrane|basolateral plasma membrane|chloride channel complex|early endosome membrane	ATP binding|ATP-binding and phosphorylation-dependent chloride channel activity|channel-conductance-controlling ATPase activity|chloride channel regulator activity|enzyme binding|PDZ domain binding			central_nervous_system(2)|skin(2)|ovary(1)	5	Lung NSC(10;0.00148)|all_lung(10;0.00171)		STAD - Stomach adenocarcinoma(10;0.000534)		Bumetanide(DB00887)|Glibenclamide(DB01016)	TTCTCAATAAGTCCTGGCCAG	0.438		NA							Cystic_Fibrosis				11	43					0.00136819	0.00146491	1	0
CTTNBP2	83992	broad.mit.edu	37	7	117432538	117432538	+	Silent	SNP	G	G	T			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr7:117432538G>T	uc003vjf.2	-	4	804	c.712C>A	c.(712-714)CGG>AGG	p.R238R		NM_033427	NP_219499	Q8WZ74	CTTB2_HUMAN	cortactin binding protein 2	238	Potential.									ovary(4)|central_nervous_system(1)	5	Lung NSC(10;0.0018)|all_lung(10;0.002)			LUSC - Lung squamous cell carcinoma(290;0.133)		AGCTGTTCCCGCTCAGTGTCA	0.453		NA											13	39					2.27e-07	2.69e-07	1	0
KCND2	3751	broad.mit.edu	37	7	119915355	119915355	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr7:119915355G>T	uc003vjj.1	+	1	1634	c.669G>T	c.(667-669)GAG>GAT	p.E223D		NM_012281	NP_036413	Q9NZV8	KCND2_HUMAN	potassium voltage-gated channel, Shal-related	223					regulation of action potential|synaptic transmission	cell surface|dendritic spine	metal ion binding			ovary(2)|central_nervous_system(2)|skin(1)	5	all_neural(327;0.117)					CCTGTGGAGAGCGGTATGCTG	0.542		NA											27	39					7.42e-09	9.08e-09	1	0
EXOC4	60412	broad.mit.edu	37	7	133502223	133502223	+	Missense_Mutation	SNP	A	A	G			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr7:133502223A>G	uc003vrk.2	+	11	1695	c.1660A>G	c.(1660-1662)ACA>GCA	p.T554A	EXOC4_uc011kpo.1_Missense_Mutation_p.T453A|EXOC4_uc003vrl.2_Missense_Mutation_p.T164A|EXOC4_uc011kpp.1_Missense_Mutation_p.T86A	NM_021807	NP_068579	Q96A65	EXOC4_HUMAN	SEC8 protein isoform a	554					vesicle docking involved in exocytosis	exocyst	protein N-terminus binding			ovary(4)|large_intestine(3)|upper_aerodigestive_tract(1)|skin(1)	9		Esophageal squamous(399;0.129)				AGTCACTAAAACATCTGACCC	0.443		NA											18	23					0	0	0	0
DENND2A	27147	broad.mit.edu	37	7	140301270	140301270	+	Missense_Mutation	SNP	A	A	C			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr7:140301270A>C	uc010lnj.2	-	1	1073	c.928T>G	c.(928-930)TCT>GCT	p.S310A	DENND2A_uc011kre.1_RNA|DENND2A_uc010lnk.2_Missense_Mutation_p.S310A|DENND2A_uc003vvw.2_Missense_Mutation_p.S310A|DENND2A_uc003vvx.2_Missense_Mutation_p.S310A	NM_015689	NP_056504	Q9ULE3	DEN2A_HUMAN	DENN/MADD domain containing 2A	310								p.S310A(1)		ovary(3)|breast(1)	4	Melanoma(164;0.00956)					ggtgggggagaggagggcaga	0.403		NA											14	37					0	0	0	0
MGAM	8972	broad.mit.edu	37	7	141727480	141727480	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr7:141727480C>T	uc003vwy.2	+	10	1220	c.1166C>T	c.(1165-1167)ACC>ATC	p.T389I		NM_004668	NP_004659	O43451	MGA_HUMAN	maltase-glucoamylase	389	Lumenal (Potential).|Maltase.				polysaccharide digestion|starch catabolic process	apical plasma membrane|integral to membrane	carbohydrate binding|glucan 1,4-alpha-glucosidase activity|maltose alpha-glucosidase activity			ovary(2)	2	Melanoma(164;0.0272)				Acarbose(DB00284)|Miglitol(DB00491)|Voglibose(DB04878)	GAATATGGAACCTTAGACAAC	0.463		NA											12	28					0	0	0	0
OR9A2	135924	broad.mit.edu	37	7	142723861	142723861	+	Missense_Mutation	SNP	A	A	T			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr7:142723861A>T	uc003wcc.1	-	1	359	c.359T>A	c.(358-360)GTG>GAG	p.V120E		NM_001001658	NP_001001658	Q8NGT5	OR9A2_HUMAN	olfactory receptor, family 9, subfamily A,	120	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	Melanoma(164;0.059)					ACACACAGCCACATAACGGTC	0.438		NA											28	57					0	0	0	0
TAS2R60	338398	broad.mit.edu	37	7	143141256	143141256	+	Silent	SNP	C	C	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr7:143141256C>A	uc011ktg.1	+	1	711	c.711C>A	c.(709-711)CCC>CCA	p.P237P	uc003wda.2_Intron	NM_177437	NP_803186	P59551	T2R60_HUMAN	taste receptor, type 2, member 60	237	Helical; Name=6; (Potential).				sensory perception of bitter taste	integral to membrane	G-protein coupled receptor activity			skin(6)	6	Melanoma(164;0.172)					TCCGAGAGCCCAGTGTGCAGG	0.483		NA											38	69					2.1e-21	2.93e-21	1	0
CNTNAP2	26047	broad.mit.edu	37	7	146741075	146741075	+	Missense_Mutation	SNP	G	G	C	rs138738227	by1000genomes	TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr7:146741075G>C	uc003weu.1	+	4	995	c.479G>C	c.(478-480)CGC>CCC	p.R160P		NM_014141	NP_054860	Q9UHC6	CNTP2_HUMAN	cell recognition molecule Caspr2 precursor	160	F5/8 type C.|Extracellular (Potential).				behavior|cell adhesion|clustering of voltage-gated potassium channels|limbic system development|neuron recognition|signal transduction|striatum development|superior temporal gyrus development|thalamus development|transmission of nerve impulse	axolemma|cell body fiber|dendrite|juxtaparanode region of axon|voltage-gated potassium channel complex	receptor binding			ovary(9)|central_nervous_system(1)|pancreas(1)	11	Melanoma(164;0.153)	all_cancers(3;3.51e-10)|all_epithelial(3;1.4e-05)|Myeloproliferative disorder(3;0.00452)|Lung NSC(3;0.0067)|all_lung(3;0.00794)	OV - Ovarian serous cystadenocarcinoma(82;0.0319)			CGCTATGTGCGCATAGTGCCT	0.433		NA								HNSCC(39;0.1)			27	79					0	0	0	0
KCNH2	3757	broad.mit.edu	37	7	150644574	150644574	+	Silent	SNP	G	G	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr7:150644574G>A	uc003wic.2	-	13	3007	c.2994C>T	c.(2992-2994)TTC>TTT	p.F998F	KCNH2_uc003wib.2_Silent_p.F658F|KCNH2_uc011kux.1_Silent_p.F902F	NM_000238	NP_000229	Q12809	KCNH2_HUMAN	voltage-gated potassium channel, subfamily H,	998	Cytoplasmic (Potential).				blood circulation|muscle contraction|regulation of heart contraction|regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|two-component sensor activity			skin(3)|ovary(1)	4	all_neural(206;0.219)		OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)	Amiodarone(DB01118)|Amsacrine(DB00276)|Astemizole(DB00637)|Carvedilol(DB01136)|Cisapride(DB00604)|Dofetilide(DB00204)|Halofantrine(DB01218)|Ibutilide(DB00308)|Pimozide(DB01100)|Propafenone(DB01182)|Quinidine(DB00908)|Sertindole(DB06144)|Sotalol(DB00489)|Terfenadine(DB00342)|Verapamil(DB00661)	CCCAGAAGCTGAAAATGTTGG	0.692		NA											5	11					0	0	0	0
DPP6	1804	broad.mit.edu	37	7	154684051	154684051	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr7:154684051C>G	uc003wlk.2	+	26	2588	c.2459C>G	c.(2458-2460)CCG>CGG	p.P820R	DPP6_uc003wli.2_Missense_Mutation_p.P756R|DPP6_uc003wlm.2_Missense_Mutation_p.P758R|DPP6_uc011kvq.1_Missense_Mutation_p.P713R	NM_130797	NP_570629	P42658	DPP6_HUMAN	dipeptidyl-peptidase 6 isoform 1	820	Extracellular (Potential).				cell death|proteolysis	integral to membrane	dipeptidyl-peptidase activity|serine-type peptidase activity			pancreas(3)|breast(1)	4	all_neural(206;0.181)	all_hematologic(28;0.0044)|all_lung(21;0.0176)|Lung NSC(21;0.0204)	OV - Ovarian serous cystadenocarcinoma(82;0.0562)			CAGATTTACCCGGACGAAAGC	0.517		NA											30	48					0	0	0	0
EN2	2020	broad.mit.edu	37	7	155255140	155255140	+	Nonsense_Mutation	SNP	G	G	T			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr7:155255140G>T	uc003wmb.2	+	2	1009	c.760G>T	c.(760-762)GAG>TAG	p.E254*		NM_001427	NP_001418	P19622	HME2_HUMAN	engrailed homeobox 2	254	Homeobox.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)	1	all_neural(206;0.119)	all_hematologic(28;0.0592)	OV - Ovarian serous cystadenocarcinoma(82;0.011)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		CTTTACCGCCGAGCAGCTGCA	0.607		NA											26	85					5.45e-15	7.32e-15	1	0
WDR60	55112	broad.mit.edu	37	7	158718989	158718989	+	Missense_Mutation	SNP	A	A	T			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr7:158718989A>T	uc003woe.3	+	18	2527	c.2369A>T	c.(2368-2370)GAA>GTA	p.E790V	WDR60_uc010lqv.2_RNA|WDR60_uc010lqw.2_Missense_Mutation_p.E422V	NM_018051	NP_060521	Q8WVS4	WDR60_HUMAN	WD repeat domain 60	790	WD 2.									ovary(2)|breast(1)|central_nervous_system(1)	4	Ovarian(565;0.152)	all_cancers(7;1.25e-09)|all_epithelial(9;0.000894)|all_hematologic(28;0.00603)	OV - Ovarian serous cystadenocarcinoma(82;0.00174)	UCEC - Uterine corpus endometrioid carcinoma (81;0.19)|STAD - Stomach adenocarcinoma(7;0.18)		TCTACTCAAGAAGGTACGTGA	0.388		NA											6	12					0	0	0	0
CSMD1	64478	broad.mit.edu	37	8	2820916	2820916	+	Silent	SNP	G	G	T			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr8:2820916G>T	uc011kwk.1	-	60	9675	c.9285C>A	c.(9283-9285)GCC>GCA	p.A3095A	CSMD1_uc011kwj.1_Silent_p.A2424A|CSMD1_uc010lrg.2_Silent_p.A986A	NM_033225	NP_150094	Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1 precursor	3095	Extracellular (Potential).|Sushi 24.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		GACACAGCACGGCTATTTCCA	0.498		NA											51	101					6.57e-35	9.57e-35	1	0
SOX7	83595	broad.mit.edu	37	8	10583781	10583781	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr8:10583781C>A	uc003wtf.2	-	2	713	c.634G>T	c.(634-636)GTG>TTG	p.V212L	SOX7_uc011kwz.1_Missense_Mutation_p.V264L	NM_031439	NP_113627	Q9BT81	SOX7_HUMAN	SRY-box 7	212					endoderm formation|negative regulation of cell proliferation|negative regulation of transcription, DNA-dependent|positive regulation of caspase activity|regulation of canonical Wnt receptor signaling pathway	cytoplasm|nucleus	transcription regulatory region DNA binding			breast(1)	1				COAD - Colon adenocarcinoma(149;0.0732)		GGCTCCAGCACGTCCAGGGGA	0.701		NA											17	25					7.08e-05	7.82e-05	1	0
DLC1	10395	broad.mit.edu	37	8	12957730	12957730	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr8:12957730C>T	uc003wwm.2	-	9	2560	c.2116G>A	c.(2116-2118)GAG>AAG	p.E706K	DLC1_uc003wwk.1_Missense_Mutation_p.E269K|DLC1_uc003wwl.1_Missense_Mutation_p.E303K|DLC1_uc011kxx.1_Missense_Mutation_p.E195K	NM_182643	NP_872584	Q96QB1	RHG07_HUMAN	deleted in liver cancer 1 isoform 1	706					actin cytoskeleton organization|activation of caspase activity|focal adhesion assembly|forebrain development|heart morphogenesis|hindbrain morphogenesis|induction of apoptosis|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of Rho protein signal transduction|negative regulation of stress fiber assembly|neural tube closure|positive regulation of protein dephosphorylation|regulation of cell shape|small GTPase mediated signal transduction	caveola|cytosol|focal adhesion|nucleus	Rho GTPase activator activity|SH2 domain binding			ovary(3)|pancreas(2)|lung(1)|kidney(1)	7						TTCAGCTTCTCCTCATCCATC	0.567		NA											21	33					0	0	0	0
UNC5D	137970	broad.mit.edu	37	8	35406851	35406851	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr8:35406851G>C	uc003xjr.1	+	2	473	c.145G>C	c.(145-147)GCT>CCT	p.A49P	UNC5D_uc003xjs.1_Missense_Mutation_p.A44P	NM_080872	NP_543148	Q6UXZ4	UNC5D_HUMAN	unc-5 homolog D precursor	49	Extracellular (Potential).				apoptosis|axon guidance	integral to membrane	receptor activity			upper_aerodigestive_tract(2)|ovary(2)|pancreas(1)|skin(1)	6				READ - Rectum adenocarcinoma(1;1.31e-05)|Colorectal(1;0.000723)		CATCCCATCAGCTCCTGGGAC	0.483		NA											13	40					0	0	0	0
KCNU1	157855	broad.mit.edu	37	8	36776389	36776389	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr8:36776389G>A	uc010lvw.2	+	23	2657	c.2570G>A	c.(2569-2571)CGA>CAA	p.R857Q	KCNU1_uc003xjw.2_RNA	NM_001031836	NP_001027006	A8MYU2	KCNU1_HUMAN	potassium channel, subfamily U, member 1	857	Cytoplasmic (Potential).					voltage-gated potassium channel complex	binding|large conductance calcium-activated potassium channel activity|voltage-gated potassium channel activity			ovary(1)	1				KIRC - Kidney renal clear cell carcinoma(67;0.0504)|Kidney(114;0.0634)		TCAAACTGCCGAAAAGTCCCT	0.358		NA											17	84					0	0	0	0
DDHD2	23259	broad.mit.edu	37	8	38095108	38095108	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr8:38095108C>G	uc003xlb.2	+	4	841	c.464C>G	c.(463-465)TCT>TGT	p.S155C	DDHD2_uc003xla.2_Missense_Mutation_p.S155C|DDHD2_uc003xlc.2_Missense_Mutation_p.S155C|DDHD2_uc011lbl.1_Missense_Mutation_p.I7M	NM_015214	NP_056029	O94830	DDHD2_HUMAN	DDHD domain containing 2 isoform 1	155					lipid catabolic process	centrosome	hydrolase activity|metal ion binding			large_intestine(1)|ovary(1)	2	Colorectal(12;0.000442)	all_lung(54;0.0657)|Lung NSC(58;0.175)	BRCA - Breast invasive adenocarcinoma(5;3.76e-25)|COAD - Colon adenocarcinoma(9;0.0977)			AAACTGGAATCTCCCAACAGA	0.328		NA											7	14					0	0	0	0
PXDNL	137902	broad.mit.edu	37	8	52287228	52287228	+	Silent	SNP	A	A	G			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr8:52287228A>G	uc003xqu.3	-	18	3722	c.3621T>C	c.(3619-3621)CCT>CCC	p.P1207P	PXDNL_uc003xqt.3_RNA	NM_144651	NP_653252	A1KZ92	PXDNL_HUMAN	peroxidasin homolog-like precursor	1207					hydrogen peroxide catabolic process	extracellular space	heme binding|peroxidase activity			ovary(1)|pancreas(1)	2		all_cancers(86;0.107)|Lung NSC(129;0.00641)|all_epithelial(80;0.00716)|all_lung(136;0.015)				CTCTTGTACCAGGAATCAGGT	0.483		NA											12	39					0	0	0	0
EYA1	2138	broad.mit.edu	37	8	72182001	72182001	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr8:72182001C>A	uc003xys.3	-	10	1311	c.1024G>T	c.(1024-1026)GGG>TGG	p.G342W	EYA1_uc003xyr.3_Missense_Mutation_p.G337W|EYA1_uc003xyt.3_Missense_Mutation_p.G309W|EYA1_uc010lzf.2_Missense_Mutation_p.G269W|EYA1_uc003xyu.2_Missense_Mutation_p.G342W|EYA1_uc011lfe.1_Missense_Mutation_p.G336W|EYA1_uc003xyv.2_Missense_Mutation_p.G220W	NM_172058	NP_742055	Q99502	EYA1_HUMAN	eyes absent 1 isoform b	342					double-strand break repair|histone dephosphorylation|positive regulation of DNA repair|protein sumoylation|regulation of transcription, DNA-dependent|response to ionizing radiation|sensory perception of sound|transcription, DNA-dependent	cytoplasm|nucleus	metal ion binding|protein tyrosine phosphatase activity			ovary(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	5	Breast(64;0.046)		Epithelial(68;0.0837)|all cancers(69;0.247)			GCGTAGGACCCAGTAAGCAAG	0.398		NA											33	91					6.29e-14	8.36e-14	1	0
EYA1	2138	broad.mit.edu	37	8	72229917	72229917	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr8:72229917C>G	uc003xys.3	-	6	713	c.426G>C	c.(424-426)TTG>TTC	p.L142F	EYA1_uc003xyr.3_Intron|EYA1_uc003xyt.3_Missense_Mutation_p.L109F|EYA1_uc010lzf.2_Missense_Mutation_p.L69F|EYA1_uc003xyu.2_Missense_Mutation_p.L142F|EYA1_uc011lfe.1_Intron|EYA1_uc003xyv.2_Intron	NM_172058	NP_742055	Q99502	EYA1_HUMAN	eyes absent 1 isoform b	142					double-strand break repair|histone dephosphorylation|positive regulation of DNA repair|protein sumoylation|regulation of transcription, DNA-dependent|response to ionizing radiation|sensory perception of sound|transcription, DNA-dependent	cytoplasm|nucleus	metal ion binding|protein tyrosine phosphatase activity			ovary(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	5	Breast(64;0.046)		Epithelial(68;0.0837)|all cancers(69;0.247)			TGCCTGCCCACAATGCACCTA	0.423		NA											37	96					0	0	0	0
MSC	9242	broad.mit.edu	37	8	72756070	72756070	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr8:72756070C>T	uc003xyx.1	-	1	662	c.344G>A	c.(343-345)CGT>CAT	p.R115H	uc011lff.1_Intron|uc003xyy.2_5'Flank	NM_005098	NP_005089	O60682	MUSC_HUMAN	musculin	115	Basic motif.				transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity				0	Breast(64;0.176)		Epithelial(68;0.137)|BRCA - Breast invasive adenocarcinoma(89;0.203)			GGCACGCTCACGGGCGTTGGC	0.692		NA									OREG0018826	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	6	17					0	0	0	0
TRPA1	8989	broad.mit.edu	37	8	72951141	72951141	+	Missense_Mutation	SNP	T	T	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr8:72951141T>A	uc003xza.2	-	19	2429	c.2254A>T	c.(2254-2256)ATC>TTC	p.I752F	uc011lff.1_Intron|uc003xyy.2_Intron	NM_007332	NP_015628	O75762	TRPA1_HUMAN	ankyrin-like protein 1	752	Extracellular (Potential).					integral to plasma membrane				ovary(4)|lung(1)|kidney(1)	6			Epithelial(68;0.223)		Menthol(DB00825)	GTTTCATTGATGATGCCAGTT	0.299		NA											26	46					0	0	0	0
TPD52	7163	broad.mit.edu	37	8	80976829	80976829	+	Splice_Site	SNP	C	C	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr8:80976829C>A	uc003ybr.1	-	2	462	c.140_splice	c.e2-1	p.G47_splice	TPD52_uc010lzr.2_Splice_Site|TPD52_uc010lzs.1_Splice_Site|TPD52_uc003ybs.1_Splice_Site_p.G7_splice|TPD52_uc003ybt.1_Splice_Site_p.G7_splice|TPD52_uc003ybq.1_Splice_Site|TPD52_uc003ybu.1_Splice_Site	NM_001025252	NP_001020423	P55327	TPD52_HUMAN	tumor protein D52 isoform 1						anatomical structure morphogenesis|B cell differentiation|secretion	endoplasmic reticulum|perinuclear region of cytoplasm	calcium ion binding|protein heterodimerization activity|protein homodimerization activity			ovary(1)	1	all_epithelial(4;1.13e-09)|Lung NSC(7;9.71e-07)|all_lung(9;3.75e-06)	Lung NSC(129;3.55e-06)|all_lung(136;1.53e-05)|Acute lymphoblastic leukemia(644;0.158)	BRCA - Breast invasive adenocarcinoma(6;0.00181)|Epithelial(68;0.0149)|all cancers(69;0.0612)			CTCAGCAGACCTGGTTGGGGA	0.463		NA											40	81					8.69e-16	1.18e-15	1	0
VPS13B	157680	broad.mit.edu	37	8	100523713	100523713	+	Missense_Mutation	SNP	A	A	T			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr8:100523713A>T	uc003yiv.2	+	29	4792	c.4681A>T	c.(4681-4683)ACA>TCA	p.T1561S	VPS13B_uc003yiw.2_Missense_Mutation_p.T1536S|VPS13B_uc003yix.1_Missense_Mutation_p.T1031S	NM_017890	NP_060360	Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13B isoform 5	1561					protein transport					ovary(7)|skin(4)|lung(3)|central_nervous_system(2)|pancreas(2)|breast(1)|kidney(1)	20	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			TATTCCAAAAACAGAAGAAAT	0.343		NA											13	25					0	0	0	0
RIMS2	9699	broad.mit.edu	37	8	104898351	104898351	+	Silent	SNP	C	C	T			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr8:104898351C>T	uc003yls.2	+	2	1099	c.858C>T	c.(856-858)CGC>CGT	p.R286R	RIMS2_uc003ylp.2_Silent_p.R508R|RIMS2_uc003ylw.2_Silent_p.R316R|RIMS2_uc003ylq.2_Silent_p.R316R|RIMS2_uc003ylr.2_Silent_p.R316R	NM_014677	NP_055492	Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	539					intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			ovary(6)|lung(2)|breast(2)|skin(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	15			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			GTAAAATGCGCCAGATTTCGT	0.423		NA								HNSCC(12;0.0054)			13	24					0	0	0	0
RIMS2	9699	broad.mit.edu	37	8	104922385	104922385	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr8:104922385G>C	uc003yls.2	+	3	1223	c.982G>C	c.(982-984)GAT>CAT	p.D328H	RIMS2_uc003ylp.2_Missense_Mutation_p.D550H|RIMS2_uc003ylw.2_Missense_Mutation_p.D358H|RIMS2_uc003ylq.2_Missense_Mutation_p.D358H|RIMS2_uc003ylr.2_Intron|RIMS2_uc003ylt.2_5'Flank	NM_014677	NP_055492	Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			ovary(6)|lung(2)|breast(2)|skin(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	15			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			CAACTGGTTGGATCATACGTC	0.393		NA								HNSCC(12;0.0054)			32	91					0	0	0	0
PKHD1L1	93035	broad.mit.edu	37	8	110455181	110455181	+	Missense_Mutation	SNP	T	T	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr8:110455181T>A	uc003yne.2	+	36	4504	c.4400T>A	c.(4399-4401)TTT>TAT	p.F1467Y		NM_177531	NP_803875	Q86WI1	PKHL1_HUMAN	fibrocystin L precursor	1467	Extracellular (Potential).|IPT/TIG 7.				immune response	cytosol|extracellular space|integral to membrane	receptor activity			ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			GCAGGTTCATTTTCTTACCAA	0.318		NA								HNSCC(38;0.096)			21	36					0	0	0	0
CSMD3	114788	broad.mit.edu	37	8	113267587	113267587	+	Nonsense_Mutation	SNP	G	G	T			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr8:113267587G>T	uc003ynu.2	-	62	10091	c.9932C>A	c.(9931-9933)TCA>TAA	p.S3311*	CSMD3_uc003yns.2_Nonsense_Mutation_p.S2513*|CSMD3_uc003ynt.2_Nonsense_Mutation_p.S3271*|CSMD3_uc011lhx.1_Nonsense_Mutation_p.S3142*	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	3311	Extracellular (Potential).|Sushi 26.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						TGAAACCTCTGACTGGTATAT	0.418		NA								HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			27	50					1.43e-11	1.84e-11	1	0
CSMD3	114788	broad.mit.edu	37	8	113668416	113668416	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr8:113668416G>T	uc003ynu.2	-	18	3130	c.2971C>A	c.(2971-2973)CGT>AGT	p.R991S	CSMD3_uc003yns.2_Missense_Mutation_p.R263S|CSMD3_uc003ynt.2_Missense_Mutation_p.R951S|CSMD3_uc011lhx.1_Missense_Mutation_p.R887S	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	991	Extracellular (Potential).|CUB 5.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						TTATTGGAACGACTGTTGTCT	0.328		NA								HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			26	70					4.78e-09	5.87e-09	1	0
C8orf85	441376	broad.mit.edu	37	8	117954796	117954796	+	Splice_Site	SNP	G	G	A	rs77850379		TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr8:117954796G>A	uc003yof.2	+	2	344	c.325_splice	c.e2-1	p.V109_splice		NM_001025357	NP_001020528	Q4LEZ3	AARD_HUMAN	alanine and arginine-rich domain-containing												0						CTAACTTTTAGGTGGAAATGC	0.343		NA											8	16					0	0	0	0
FER1L6	654463	broad.mit.edu	37	8	124978246	124978246	+	Splice_Site	SNP	G	G	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr8:124978246G>A	uc003yqw.2	+	4	404	c.198_splice	c.e4-1	p.R66_splice		NM_001039112	NP_001034201	Q2WGJ9	FR1L6_HUMAN	fer-1-like 6							integral to membrane				ovary(5)|skin(5)|central_nervous_system(1)	11	Lung NSC(37;4.1e-12)|Ovarian(258;0.00438)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00186)			TCTTTTAATAGATCAAAACTG	0.358		NA											6	21					0	0	0	0
KCNQ3	3786	broad.mit.edu	37	8	133175730	133175730	+	Missense_Mutation	SNP	A	A	T			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr8:133175730A>T	uc003ytj.2	-	9	1472	c.1247T>A	c.(1246-1248)CTG>CAG	p.L416Q	KCNQ3_uc010mdt.2_Missense_Mutation_p.L416Q	NM_004519	NP_004510	O43525	KCNQ3_HUMAN	potassium voltage-gated channel KQT-like protein	416					axon guidance|synaptic transmission	voltage-gated potassium channel complex	voltage-gated potassium channel activity			ovary(2)|breast(1)|central_nervous_system(1)|skin(1)	5	Esophageal squamous(12;0.00507)|Ovarian(258;0.00579)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000311)			TGCTGCCTCCAGCTGTTCTTT	0.443		NA											22	48					0	0	0	0
FAM135B	51059	broad.mit.edu	37	8	139263091	139263091	+	Silent	SNP	A	A	G			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr8:139263091A>G	uc003yuy.2	-	6	706	c.535T>C	c.(535-537)TTG>CTG	p.L179L	FAM135B_uc003yux.2_Silent_p.L80L|FAM135B_uc003yuz.2_RNA	NM_015912	NP_056996	Q49AJ0	F135B_HUMAN	hypothetical protein LOC51059	179										ovary(7)|skin(2)	9	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			TACCTGATCAATGGCTGCTGC	0.562		NA								HNSCC(54;0.14)			30	50					0	0	0	0
COL22A1	169044	broad.mit.edu	37	8	139833498	139833498	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr8:139833498C>A	uc003yvd.2	-	7	1573	c.1126G>T	c.(1126-1128)GTC>TTC	p.V376F		NM_152888	NP_690848	Q8NFW1	COMA1_HUMAN	collagen, type XXII, alpha 1	376	TSP N-terminal.				cell adhesion	collagen|cytoplasm	structural molecule activity			ovary(11)|pancreas(1)|skin(1)	13	all_epithelial(106;1.55e-12)|Lung NSC(106;1.67e-05)|all_lung(105;3.39e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0517)			TGCAGGGAGACGTTCTGGGCC	0.562		NA								HNSCC(7;0.00092)			21	45					4.97e-08	5.97e-08	1	0
KIAA1539	80256	broad.mit.edu	37	9	35107838	35107838	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr9:35107838C>T	uc003zwl.2	-	3	759	c.434G>A	c.(433-435)TGC>TAC	p.C145Y	KIAA1539_uc003zwm.2_Missense_Mutation_p.C145Y|KIAA1539_uc003zwn.2_Intron|KIAA1539_uc003zwo.2_Missense_Mutation_p.C145Y|KIAA1539_uc003zwp.1_Missense_Mutation_p.C145Y|KIAA1539_uc010mkk.1_Intron	NM_025182	NP_079458	Q7L5A3	K1539_HUMAN	hypothetical protein LOC80256	145						nucleus				ovary(2)	2	all_epithelial(49;0.217)		LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00778)			TGATGGGGGGCAGGGGGGACT	0.627		NA											31	57					0	0	0	0
RUSC2	9853	broad.mit.edu	37	9	35556330	35556330	+	Silent	SNP	G	G	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr9:35556330G>A	uc003zww.2	+	5	3123	c.2868G>A	c.(2866-2868)CTG>CTA	p.L956L	RUSC2_uc010mkq.2_RNA|RUSC2_uc003zwx.3_Silent_p.L956L	NM_014806	NP_055621	Q8N2Y8	RUSC2_HUMAN	RUN and SH3 domain containing 2	956						cytosol				ovary(1)	1			Lung(28;0.000837)|LUSC - Lung squamous cell carcinoma(32;0.00109)|STAD - Stomach adenocarcinoma(86;0.194)			CGTTACCACTGACCTGCCCTG	0.542		NA											27	48					0	0	0	0
FAM75A6	389730	broad.mit.edu	37	9	43625328	43625328	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr9:43625328C>A	uc011lrb.1	-	4	3388	c.3359G>T	c.(3358-3360)AGG>ATG	p.R1120M		NM_001145196	NP_001138668	Q5VVP1	F75A6_HUMAN	hypothetical protein LOC389730	1120						integral to membrane					0						TCCTTCAAGCCTTTCTTCATG	0.473		NA											50	106					2.92e-43	4.28e-43	1	0
C9orf79	286234	broad.mit.edu	37	9	90502039	90502039	+	Silent	SNP	C	C	T			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr9:90502039C>T	uc004app.3	+	4	2672	c.2637C>T	c.(2635-2637)GCC>GCT	p.A879A	C9orf79_uc004apo.1_Silent_p.A691A	NM_178828	NP_849150	Q6ZUB1	CI079_HUMAN	chromosome 9 open reading frame 79	879						integral to membrane				ovary(3)	3						CCCCCTGGGCCTCCTGGGTAT	0.557		NA											15	21					0	0	0	0
FAM22G	441457	broad.mit.edu	37	9	99694506	99694506	+	Silent	SNP	G	G	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr9:99694506G>A	uc004awq.1	+	2	1234	c.519G>A	c.(517-519)GGG>GGA	p.G173G		NM_001045477	NP_001038942	Q5VZR2	FA22G_HUMAN	hypothetical protein LOC441457	173										skin(1)	1		Acute lymphoblastic leukemia(62;0.0527)				TGTCCCCAGGGAACGCTGGGC	0.682		NA											26	126					0	0	0	0
COL15A1	1306	broad.mit.edu	37	9	101778282	101778282	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr9:101778282G>T	uc004azb.1	+	11	1734	c.1528G>T	c.(1528-1530)GCA>TCA	p.A510S		NM_001855	NP_001846	P39059	COFA1_HUMAN	alpha 1 type XV collagen precursor	510	Nonhelical region 1 (NC1).|4.|4 X tandem repeats.				angiogenesis|cell differentiation|signal transduction	collagen type XV|extracellular space|integral to membrane	binding			ovary(6)	6		Acute lymphoblastic leukemia(62;0.0562)				AGAAGACTTGGCAGCAGCCAC	0.597		NA											9	21					4.69e-08	5.65e-08	1	0
TMEFF1	8577	broad.mit.edu	37	9	103204596	103204596	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr9:103204596C>A	uc004bay.1	+	1	409	c.376C>A	c.(376-378)CCG>ACG	p.P126T	C9orf30_uc004baw.2_Missense_Mutation_p.P126T|C9orf30_uc004bax.2_RNA	NM_003692	NP_003683	Q8IYR6	TEFF1_HUMAN	transmembrane protein with EGF-like and two	Error:Variant_position_missing_in_Q8IYR6_after_alignment					multicellular organismal development	integral to membrane|plasma membrane					0		Acute lymphoblastic leukemia(62;0.0452)				GCAGAGCCCCCCGGAGGAGGA	0.587		NA											15	36					5.01e-05	5.57e-05	1	0
ZNF462	58499	broad.mit.edu	37	9	109691071	109691071	+	Silent	SNP	A	A	G			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr9:109691071A>G	uc004bcz.2	+	3	5167	c.4878A>G	c.(4876-4878)GAA>GAG	p.E1626E	ZNF462_uc010mto.2_Silent_p.E1474E|ZNF462_uc004bda.2_Silent_p.E1474E	NM_021224	NP_067047	Q96JM2	ZN462_HUMAN	zinc finger protein 462	1626					transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(5)	5						TGACCACTGAAGTGAGCCCTT	0.557		NA											23	62					0	0	0	0
PALM2-AKAP2	445815	broad.mit.edu	37	9	112898559	112898559	+	Silent	SNP	T	T	G			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr9:112898559T>G	uc004bei.2	+	9	1623	c.1431T>G	c.(1429-1431)CCT>CCG	p.P477P	PALM2-AKAP2_uc004bek.3_Silent_p.P245P|PALM2-AKAP2_uc004bej.3_Silent_p.P245P|PALM2-AKAP2_uc004bel.1_Silent_p.P55P|AKAP2_uc011lwi.1_Silent_p.P103P|AKAP2_uc004bem.2_Silent_p.P103P|PALM2-AKAP2_uc010mtw.1_Silent_p.P63P|AKAP2_uc011lwj.1_Silent_p.P14P|PALM2-AKAP2_uc004ben.2_Silent_p.P14P	NM_001136562	NP_001130034	Q9Y2D5	AKAP2_HUMAN	A kinase (PRKA) anchor protein 2 isoform 2	14							enzyme binding			ovary(3)|central_nervous_system(2)|skin(1)	6						AAAGTGTTCCTGGAATCACCT	0.502		NA											31	88					0	0	0	0
PALM2-AKAP2	445815	broad.mit.edu	37	9	112899252	112899252	+	Silent	SNP	G	G	T			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr9:112899252G>T	uc004bei.2	+	9	2316	c.2124G>T	c.(2122-2124)CCG>CCT	p.P708P	PALM2-AKAP2_uc004bek.3_Silent_p.P476P|PALM2-AKAP2_uc004bej.3_Silent_p.P476P|PALM2-AKAP2_uc004bel.1_Silent_p.P286P|AKAP2_uc011lwi.1_Silent_p.P334P|AKAP2_uc004bem.2_Silent_p.P334P|PALM2-AKAP2_uc010mtw.1_Silent_p.P294P|AKAP2_uc011lwj.1_Silent_p.P245P|PALM2-AKAP2_uc004ben.2_Silent_p.P245P	NM_001136562	NP_001130034	Q9Y2D5	AKAP2_HUMAN	A kinase (PRKA) anchor protein 2 isoform 2	245	Potential.						enzyme binding			ovary(3)|central_nervous_system(2)|skin(1)	6						GGAATCCCCCGCAGGAAAAAA	0.498		NA											18	42					5.39e-06	6.14e-06	1	0
ASTN2	23245	broad.mit.edu	37	9	119202971	119202971	+	Silent	SNP	C	C	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr9:119202971C>A	uc004bjs.1	-	22	3800	c.3699G>T	c.(3697-3699)CTG>CTT	p.L1233L	ASTN2_uc004bjr.1_Silent_p.L1229L|ASTN2_uc004bjt.1_Silent_p.L1182L|ASTN2_uc004bjp.1_Silent_p.L326L|ASTN2_uc004bjq.1_Silent_p.L285L|ASTN2_uc011lxr.1_Silent_p.L285L|ASTN2_uc011lxs.1_Silent_p.L285L|ASTN2_uc011lxt.1_Silent_p.L285L|ASTN2_uc004bjo.1_Silent_p.L14L	NM_198187	NP_937830	O75129	ASTN2_HUMAN	astrotactin 2 isoform c	1233	Extracellular (Potential).					integral to membrane				skin(4)|ovary(3)|breast(1)|kidney(1)	9						GGACTCGGAACAGCATCGAGG	0.498		NA											28	75					3.74e-20	5.19e-20	1	0
TLR4	7099	broad.mit.edu	37	9	120470943	120470943	+	Silent	SNP	C	C	T			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr9:120470943C>T	uc004bjz.2	+	2	487	c.196C>T	c.(196-198)CTG>TTG	p.L66L	TLR4_uc004bka.2_Silent_p.L26L|TLR4_uc004bkb.2_Intron	NM_138554	NP_612564	O00206	TLR4_HUMAN	toll-like receptor 4 precursor	66	LRR 1.|Extracellular (Potential).				activation of MAPK activity|cellular response to mechanical stimulus|detection of fungus|detection of lipopolysaccharide|I-kappaB phosphorylation|innate immune response|intestinal epithelial structure maintenance|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of ERK1 and ERK2 cascade|negative regulation of interferon-gamma production|negative regulation of interleukin-17 production|negative regulation of interleukin-23 production|negative regulation of interleukin-6 production|negative regulation of osteoclast differentiation|negative regulation of tumor necrosis factor production|positive regulation of chemokine production|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of interferon-gamma production|positive regulation of interleukin-1 production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 biosynthetic process|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 biosynthetic process|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of platelet activation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor biosynthetic process|positive regulation of tumor necrosis factor production|T-helper 1 type immune response|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	external side of plasma membrane|integral to plasma membrane|lipopolysaccharide receptor complex|perinuclear region of cytoplasm	lipopolysaccharide receptor activity|transmembrane receptor activity			lung(10)|ovary(4)|breast(1)|skin(1)	16						CTTTAATCCCCTGAGGCATTT	0.443		NA											52	132					0	0	0	0
OR1L1	26737	broad.mit.edu	37	9	125424532	125424532	+	Missense_Mutation	SNP	G	G	T	rs142065229		TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr9:125424532G>T	uc011lza.1	+	1	688	c.688G>T	c.(688-690)GAT>TAT	p.D230Y		NM_001005236	NP_001005236	Q8NH94	OR1L1_HUMAN	olfactory receptor, family 1, subfamily L,	230	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(3)|ovary(1)	4						CTTTTTCTGCGATGATCAACC	0.428		NA											59	123					4.96e-28	7.15e-28	1	0
GLRA2	2742	broad.mit.edu	37	X	14627215	14627215	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chrX:14627215G>C	uc010nep.2	+	8	1150	c.818G>C	c.(817-819)TGG>TCG	p.W273S	GLRA2_uc010neq.2_Missense_Mutation_p.W273S|GLRA2_uc004cwe.3_Missense_Mutation_p.W273S|GLRA2_uc011mio.1_Missense_Mutation_p.W184S|GLRA2_uc011mip.1_Missense_Mutation_p.W251S	NM_001118885	NP_001112357	P23416	GLRA2_HUMAN	glycine receptor, alpha 2 isoform A	273	Helical; (Probable).				neuropeptide signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	extracellular-glycine-gated chloride channel activity|glycine binding|receptor activity|transmitter-gated ion channel activity			ovary(1)|lung(1)	2	Hepatocellular(33;0.128)				Ethanol(DB00898)|Glycine(DB00145)	ATTTTGTCCTGGGTTTCCTTT	0.473		NA											51	29					0	0	0	0
NHS	4810	broad.mit.edu	37	X	17739579	17739579	+	Nonsense_Mutation	SNP	G	G	T			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chrX:17739579G>T	uc004cxx.2	+	4	1209	c.871G>T	c.(871-873)GAA>TAA	p.E291*	NHS_uc011mix.1_Nonsense_Mutation_p.E312*|NHS_uc004cxy.2_Nonsense_Mutation_p.E135*|NHS_uc004cxz.2_Nonsense_Mutation_p.E114*|NHS_uc004cya.2_Nonsense_Mutation_p.E14*	NM_198270	NP_938011	Q6T4R5	NHS_HUMAN	Nance-Horan syndrome protein isoform 1	291						nucleus				skin(3)|ovary(2)|breast(1)|central_nervous_system(1)	7	Hepatocellular(33;0.183)					CCCAGAGGATGAAGATACAGA	0.433		NA											25	13					4.6e-10	5.76e-10	1	0
DMD	1756	broad.mit.edu	37	X	32459328	32459328	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chrX:32459328C>G	uc004dda.1	-	28	4134	c.3890G>C	c.(3889-3891)GGC>GCC	p.G1297A	DMD_uc004dcz.2_Missense_Mutation_p.G1174A|DMD_uc004dcy.1_Missense_Mutation_p.G1293A|DMD_uc004ddb.1_Missense_Mutation_p.G1289A|DMD_uc010ngo.1_Intron	NM_004006	NP_003997	P11532	DMD_HUMAN	dystrophin Dp427m isoform	1297	Spectrin 9.				muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			ovary(3)|pancreas(2)|large_intestine(1)	6		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				CTCAGCTCCGCCAGGAATGTT	0.358		NA											31	21					0	0	0	0
FAM47B	170062	broad.mit.edu	37	X	34962223	34962223	+	Silent	SNP	G	G	T			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chrX:34962223G>T	uc004ddi.1	+	1	1293	c.1275G>T	c.(1273-1275)CCG>CCT	p.P425P		NM_152631	NP_689844	Q8NA70	FA47B_HUMAN	hypothetical protein LOC170062	425										ovary(3)|breast(1)	4						GTCTCTGCCCGGAGCCTACCA	0.547		NA											31	10					3.8e-20	5.28e-20	1	0
DGKK	139189	broad.mit.edu	37	X	50163498	50163498	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chrX:50163498G>T	uc010njr.1	-	4	905	c.845C>A	c.(844-846)ACA>AAA	p.T282K		NM_001013742	NP_001013764	Q5KSL6	DGKK_HUMAN	diacylglycerol kinase kappa	282	PH.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|diacylglycerol metabolic process|intracellular signal transduction|platelet activation|response to oxidative stress	cytoplasm|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			ovary(1)|kidney(1)	2	Ovarian(276;0.236)					TCGTTGTGGTGTAATAACCTA	0.388		NA											39	21					2.59e-14	3.46e-14	1	0
TRO	7216	broad.mit.edu	37	X	54957428	54957428	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chrX:54957428G>T	uc004dtq.2	+	12	4378	c.4271G>T	c.(4270-4272)GGT>GTT	p.G1424V	TRO_uc004dts.2_Intron|TRO_uc004dtr.2_Intron|TRO_uc004dtt.2_RNA|TRO_uc004dtu.2_RNA|TRO_uc004dtv.2_Intron|TRO_uc011mok.1_Missense_Mutation_p.G955V|TRO_uc004dtw.2_Missense_Mutation_p.G1027V|TRO_uc004dtx.2_Missense_Mutation_p.G807V	NM_001039705	NP_001034794	Q12816	TROP_HUMAN	trophinin isoform 5	1424	62; approximate.|62 X 10 AA approximate tandem repeats.				embryo implantation|homophilic cell adhesion	integral to plasma membrane				ovary(1)	1						GCCAGTCTTGGTGCCTGTGGC	0.567		NA											9	11					1.11e-13	1.47e-13	1	0
FAM123B	139285	broad.mit.edu	37	X	63410293	63410293	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chrX:63410293C>A	uc004dvo.2	-	2	3147	c.2874G>T	c.(2872-2874)TGG>TGT	p.W958C		NM_152424	NP_689637	Q5JTC6	F123B_HUMAN	family with sequence similarity 123B	958	Pro-rich.				Wnt receptor signaling pathway	cytoplasm|nucleus|plasma membrane		p.0?(40)		kidney(99)|large_intestine(6)|ovary(3)|lung(2)|breast(1)|liver(1)	112						CCCAAGCAGGCCAATCATAGG	0.577		NA											15	6					4.75e-09	5.85e-09	1	0
BRWD3	254065	broad.mit.edu	37	X	79932626	79932626	+	Missense_Mutation	SNP	T	T	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chrX:79932626T>A	uc004edt.2	-	41	5154	c.4891A>T	c.(4891-4893)ACA>TCA	p.T1631S	BRWD3_uc010nmi.1_RNA|BRWD3_uc004edo.2_Missense_Mutation_p.T1227S|BRWD3_uc004edp.2_Missense_Mutation_p.T1460S|BRWD3_uc004edq.2_Missense_Mutation_p.T1227S|BRWD3_uc010nmj.1_Missense_Mutation_p.T1227S|BRWD3_uc004edr.2_Missense_Mutation_p.T1301S|BRWD3_uc004eds.2_Missense_Mutation_p.T1227S|BRWD3_uc004edu.2_Missense_Mutation_p.T1301S|BRWD3_uc004edv.2_Missense_Mutation_p.T1227S|BRWD3_uc004edw.2_Missense_Mutation_p.T1227S|BRWD3_uc004edx.2_Missense_Mutation_p.T1227S|BRWD3_uc004edy.2_Missense_Mutation_p.T1227S|BRWD3_uc004edz.2_Missense_Mutation_p.T1301S|BRWD3_uc004eea.2_Missense_Mutation_p.T1301S|BRWD3_uc004eeb.2_Missense_Mutation_p.T1227S|uc004edn.1_5'Flank	NM_153252	NP_694984	Q6RI45	BRWD3_HUMAN	bromodomain and WD repeat domain containing 3	1631										ovary(4)	4						TCTTGATCTGTTCTGGAAGTT	0.378		NA											47	36					0	0	0	0
PABPC5	140886	broad.mit.edu	37	X	90690743	90690743	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chrX:90690743G>T	uc004efg.2	+	2	607	c.167G>T	c.(166-168)CGC>CTC	p.R56L	PABPC5_uc004eff.1_Intron	NM_080832	NP_543022	Q96DU9	PABP5_HUMAN	poly(A) binding protein, cytoplasmic 5	56	RRM 1.					cytoplasm	nucleotide binding|RNA binding			ovary(1)|lung(1)|pancreas(1)	3						CCGGTGACCCGCAGCCCCCTG	0.532		NA											9	5					5.69e-11	7.26e-11	1	0
PCDH11X	27328	broad.mit.edu	37	X	91132611	91132611	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chrX:91132611G>C	uc004efk.1	+	2	2217	c.1372G>C	c.(1372-1374)GAT>CAT	p.D458H	PCDH11X_uc004efl.1_Missense_Mutation_p.D458H|PCDH11X_uc004efo.1_Missense_Mutation_p.D458H|PCDH11X_uc010nmv.1_Missense_Mutation_p.D458H|PCDH11X_uc004efm.1_Missense_Mutation_p.D458H|PCDH11X_uc004efn.1_Missense_Mutation_p.D458H|PCDH11X_uc004efh.1_Missense_Mutation_p.D458H|PCDH11X_uc004efj.1_Missense_Mutation_p.D458H	NM_032968	NP_116750	Q9BZA7	PC11X_HUMAN	protocadherin 11 X-linked isoform c	458	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion	integral to plasma membrane	calcium ion binding			large_intestine(2)	2						CAAAGTGAAAGATGAAAATGA	0.403		NA											27	12					0	0	0	0
NXF3	56000	broad.mit.edu	37	X	102332651	102332651	+	Missense_Mutation	SNP	A	A	T			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chrX:102332651A>T	uc004eju.2	-	18	1546	c.1475T>A	c.(1474-1476)CTC>CAC	p.L492H	NXF3_uc010noi.1_3'UTR	NM_022052	NP_071335	Q9H4D5	NXF3_HUMAN	nuclear RNA export factor 3	492	NTF2.					cytoplasm|nuclear RNA export factor complex	nucleocytoplasmic transporter activity|nucleotide binding|protein binding			ovary(1)|lung(1)|central_nervous_system(1)	3						CCGCACAAAGAGCTTGTCATT	0.572		NA											42	22					0	0	0	0
TEX13A	56157	broad.mit.edu	37	X	104464879	104464879	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chrX:104464879G>A	uc004ema.2	-	2	315	c.203C>T	c.(202-204)ACC>ATC	p.T68I	IL1RAPL2_uc004elz.1_Intron|TEX13A_uc004emb.2_Missense_Mutation_p.T68I	NM_031274	NP_112564	Q9BXU3	TX13A_HUMAN	testis expressed sequence 13A	68						intracellular	zinc ion binding			ovary(2)	2						GCTGCCCCAGGTGCAGGCCTC	0.582		NA											16	11					0	0	0	0
NRK	203447	broad.mit.edu	37	X	105132386	105132386	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chrX:105132386C>A	uc004emd.2	+	5	655	c.352C>A	c.(352-354)CCC>ACC	p.P118T	NRK_uc010npc.1_5'UTR	NM_198465	NP_940867	Q7Z2Y5	NRK_HUMAN	Nik related kinase	118	Protein kinase.						ATP binding|protein serine/threonine kinase activity|small GTPase regulator activity			breast(7)|ovary(3)|lung(2)|large_intestine(1)|central_nervous_system(1)	14						CAAGCTGAGTCCCCCTGGTCA	0.398		NA								HNSCC(51;0.14)			5	2					5.94e-07	6.97e-07	1	0
BCORL1	63035	broad.mit.edu	37	X	129184758	129184758	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chrX:129184758G>T	uc004evb.1	+	11	4799	c.4685G>T	c.(4684-4686)AGT>ATT	p.S1562I	BCORL1_uc004evc.1_Missense_Mutation_p.S398I	NM_021946	NP_068765	Q5H9F3	BCORL_HUMAN	BCL6 co-repressor-like 1	1562					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus				ovary(4)|breast(2)|lung(1)	7						TTTTACAGCAGTTCTGTGTTG	0.502		NA											61	39					8.34e-18	1.15e-17	1	0
GPR101	83550	broad.mit.edu	37	X	136112905	136112905	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chrX:136112905C>T	uc011mwh.1	-	1	929	c.929G>A	c.(928-930)AGC>AAC	p.S310N		NM_054021	NP_473362	Q96P66	GP101_HUMAN	G protein-coupled receptor 101	310	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(3)|lung(1)|skin(1)	5	Acute lymphoblastic leukemia(192;0.000127)					GGCCACCGTGCTGCTCTCTCT	0.602		NA											72	51					0	0	0	0
MAGEC1	9947	broad.mit.edu	37	X	140993368	140993368	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chrX:140993368G>T	uc004fbt.2	+	4	464	c.178G>T	c.(178-180)GGG>TGG	p.G60W	MAGEC1_uc010nsl.1_Intron	NM_005462	NP_005453	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	60							protein binding			ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	4	Acute lymphoblastic leukemia(192;6.56e-05)					TCGTTCTGAGGGGGAGGACTC	0.602		NA								HNSCC(15;0.026)			42	31					4.67e-22	6.56e-22	1	0
PLXNA3	55558	broad.mit.edu	37	X	153689091	153689091	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chrX:153689091G>A	uc004flm.2	+	2	741	c.568G>A	c.(568-570)GAA>AAA	p.E190K		NM_017514	NP_059984	P51805	PLXA3_HUMAN	plexin A3 precursor	190	Sema.|Extracellular (Potential).				axon guidance	integral to membrane|intracellular|plasma membrane	transmembrane receptor activity			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	3	all_cancers(53;5.05e-16)|all_epithelial(53;1.87e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					CATCAGTGATGAAGACAGCGC	0.597		NA											29	18					0	0	0	0
PLXNA3	55558	broad.mit.edu	37	X	153693211	153693211	+	Silent	SNP	G	G	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chrX:153693211G>A	uc004flm.2	+	10	2216	c.2043G>A	c.(2041-2043)GAG>GAA	p.E681E		NM_017514	NP_059984	P51805	PLXA3_HUMAN	plexin A3 precursor	681	Extracellular (Potential).				axon guidance	integral to membrane|intracellular|plasma membrane	transmembrane receptor activity			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	3	all_cancers(53;5.05e-16)|all_epithelial(53;1.87e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					ACAGCCCTGAGGTGAGGCGGG	0.662		NA											3	2					0	0	0	0
TAS2R8	50836	broad.mit.edu	37	12	10959383	10959383	+	Frame_Shift_Del	DEL	C	C	-			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr12:10959383delC	uc010shh.1	-	1	197	c.197delG	c.(196-198)GGCfs	p.G66fs		NM_023918	NP_076407	Q9NYW2	TA2R8_HUMAN	taste receptor, type 2, member 8	66	Helical; Name=2; (Potential).				sensory perception of taste	integral to membrane	taste receptor activity			ovary(2)	2						TATTACAATGCCATTTACAAC	0.318		NA											31	72	---	---	---	---	NA	NA	NA	NA
PKP2	5318	broad.mit.edu	37	12	32975546	32975547	+	Frame_Shift_Del	DEL	CA	CA	-			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr12:32975546_32975547delCA	uc001rlj.3	-	9	1940_1941	c.1825_1826delTG	c.(1825-1827)TGCfs	p.C609fs	PKP2_uc001rlk.3_Frame_Shift_Del_p.C565fs|PKP2_uc010skj.1_Frame_Shift_Del_p.C565fs	NM_004572	NP_004563	Q99959	PKP2_HUMAN	plakophilin 2 isoform 2b	609	ARM 4.				cell-cell adhesion	desmosome|integral to membrane|nucleus	binding			ovary(1)|pancreas(1)	2	Lung NSC(5;9.35e-07)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.239)					ATGAAGAATGCACACACAATTC	0.426		NA											22	58	---	---	---	---	NA	NA	NA	NA
UNC45B	146862	broad.mit.edu	37	17	33497240	33497241	+	Frame_Shift_Ins	INS	-	-	C			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr17:33497240_33497241insC	uc002hja.2	+	12	1752_1753	c.1655_1656insC	c.(1654-1656)GTCfs	p.V552fs	UNC45B_uc002hjb.2_Frame_Shift_Ins_p.V552fs|UNC45B_uc002hjc.2_Frame_Shift_Ins_p.V552fs|UNC45B_uc010cto.2_Intron	NM_173167	NP_775259	Q8IWX7	UN45B_HUMAN	cardiomyopathy associated 4 isoform 1	552					cell differentiation|muscle organ development	cytosol	binding			ovary(3)|central_nervous_system(2)|breast(1)	6		Ovarian(249;0.17)				GTCCAGGACGTCCCTGCCCTGC	0.619		NA											15	30	---	---	---	---	NA	NA	NA	NA
FLRT3	23767	broad.mit.edu	37	20	14306693	14306694	+	Frame_Shift_Ins	INS	-	-	T	rs144984452		TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr20:14306693_14306694insT	uc002wov.1	-	3	1926_1927	c.1459_1460insA	c.(1459-1461)CTCfs	p.L487fs	MACROD2_uc002wot.2_Intron|MACROD2_uc002wou.2_Intron|FLRT3_uc002wow.1_Frame_Shift_Ins_p.L487fs	NM_198391	NP_938205	Q9NZU0	FLRT3_HUMAN	fibronectin leucine rich transmembrane protein 3	487	Extracellular (Potential).|Fibronectin type-III.				cell adhesion	integral to plasma membrane|proteinaceous extracellular matrix	protein binding, bridging|receptor signaling protein activity			kidney(1)	1		Colorectal(1;0.0464)	COAD - Colon adenocarcinoma(2;0.129)	Colorectal(1;0.0393)		AAATAGGTAGAGGTTGCTGGTT	0.455		NA											26	89	---	---	---	---	NA	NA	NA	NA
PCNT	5116	broad.mit.edu	37	21	47821563	47821563	+	Frame_Shift_Del	DEL	G	G	-			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr21:47821563delG	uc002zji.3	+	26	4997	c.4890delG	c.(4888-4890)TCGfs	p.S1630fs	PCNT_uc002zjj.2_Frame_Shift_Del_p.S1512fs	NM_006031	NP_006022	O95613	PCNT_HUMAN	pericentrin	1630	Potential.				cilium assembly|G2/M transition of mitotic cell cycle	cytosol|microtubule	calmodulin binding			ovary(4)|breast(2)|pancreas(2)	8	Breast(49;0.112)					AGCCTCCTTCGGGCAGCCCTC	0.562		NA											39	70	---	---	---	---	NA	NA	NA	NA
OR11H1	81061	broad.mit.edu	37	22	16449523	16449523	+	Frame_Shift_Del	DEL	G	G	-			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr22:16449523delG	uc011agd.1	-	1	282	c.282delC	c.(280-282)CCCfs	p.P94fs		NM_001005239	NP_001005239	Q8NG94	O11H1_HUMAN	olfactory receptor, family 11, subfamily H,	94	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_hematologic(4;0.00567)|Acute lymphoblastic leukemia(84;0.0977)	all_epithelial(15;0.208)		Kidney(3;0.00216)|KIRC - Kidney renal clear cell carcinoma(3;0.00244)|Lung(27;0.0724)|COAD - Colon adenocarcinoma(3;0.211)		CCAACATCTTGGGAACTGTAG	0.408		NA											8	57	---	---	---	---	NA	NA	NA	NA
ROBO2	6092	broad.mit.edu	37	3	77651571	77651571	+	Frame_Shift_Del	DEL	G	G	-			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr3:77651571delG	uc003dpy.3	+	20	3708	c.3065delG	c.(3064-3066)AGCfs	p.S1022fs	ROBO2_uc003dpz.2_Frame_Shift_Del_p.S1026fs|ROBO2_uc011bgj.1_RNA|ROBO2_uc011bgk.1_Frame_Shift_Del_p.S1026fs|ROBO2_uc003dqa.2_Frame_Shift_Del_p.S149fs	NM_002942	NP_002933	Q9HCK4	ROBO2_HUMAN	roundabout, axon guidance receptor, homolog 2	1022	Cytoplasmic (Potential).				apoptosis involved in luteolysis|axon midline choice point recognition|cellular response to hormone stimulus|homophilic cell adhesion|metanephros development|negative regulation of negative chemotaxis|negative regulation of synaptogenesis|olfactory bulb interneuron development|positive regulation of axonogenesis|retinal ganglion cell axon guidance|ureteric bud development	axolemma|cell surface|integral to membrane	axon guidance receptor activity|identical protein binding			lung(5)|skin(3)|ovary(1)|large_intestine(1)|liver(1)	11				Epithelial(33;0.00199)|LUSC - Lung squamous cell carcinoma(21;0.008)|BRCA - Breast invasive adenocarcinoma(55;0.00884)|Lung(72;0.0183)|KIRC - Kidney renal clear cell carcinoma(39;0.0832)|Kidney(39;0.103)		CAATGGAAAAGCTCAATTCAG	0.443		NA											23	17	---	---	---	---	NA	NA	NA	NA
SLCO2A1	6578	broad.mit.edu	37	3	133657272	133657272	+	Splice_Site	DEL	C	C	-			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr3:133657272delC	uc003eqa.3	-	12	1964	c.1690_splice	c.e12+1	p.A564_splice	SLCO2A1_uc003eqb.3_Splice_Site_p.A488_splice	NM_005630	NP_005621	Q92959	SO2A1_HUMAN	solute carrier organic anion transporter family,						sodium-independent organic anion transport	integral to plasma membrane|membrane fraction	prostaglandin transmembrane transporter activity|protein binding			central_nervous_system(1)	1						TAGACACTTACCCAGCAAGCG	0.537		NA											103	66	---	---	---	---	NA	NA	NA	NA
DBR1	51163	broad.mit.edu	37	3	137880741	137880743	+	In_Frame_Del	DEL	TCG	TCG	-	rs150114751	byFrequency	TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr3:137880741_137880743delTCG	uc003erv.2	-	8	1759_1761	c.1623_1625delCGA	c.(1621-1626)GATGAT>GAT	p.541_542DD>D	DBR1_uc003eru.2_In_Frame_Del_p.490_491DD>D|DBR1_uc003ert.2_In_Frame_Del_p.309_310DD>D	NM_016216	NP_057300	Q9UK59	DBR1_HUMAN	debranching enzyme homolog 1	541_542						nucleus	metal ion binding|RNA lariat debranching enzyme activity				0						TTAAGCTGCATCGTCATCATCAT	0.251		NA											7	167	---	---	---	---	NA	NA	NA	NA
CCDC39	339829	broad.mit.edu	37	3	180372672	180372672	+	Frame_Shift_Del	DEL	C	C	-			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr3:180372672delC	uc010hxe.2	-	7	923	c.808delG	c.(808-810)GAAfs	p.E270fs	CCDC39_uc003fkn.2_RNA	NM_181426	NP_852091	Q9UFE4	CCD39_HUMAN	coiled-coil domain containing 39	270	Potential.				axonemal dynein complex assembly|ciliary cell motility|cilium movement involved in determination of left/right asymmetry|flagellar cell motility	cilium axoneme|cytoplasm|cytoskeleton				ovary(4)	4	all_cancers(143;9.31e-15)|Ovarian(172;0.0212)		OV - Ovarian serous cystadenocarcinoma(80;5.62e-23)|GBM - Glioblastoma multiforme(14;0.000558)			ATCTCACTTTCCAAAAACTTG	0.318		NA											59	22	---	---	---	---	NA	NA	NA	NA
CDC20B	166979	broad.mit.edu	37	5	54442506	54442509	+	Frame_Shift_Del	DEL	GCTT	GCTT	-			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr5:54442506_54442509delGCTT	uc003jpo.1	-	3	477_480	c.302_305delAAGC	c.(301-306)GAAGCTfs	p.E101fs	CDC20B_uc003jpn.1_Frame_Shift_Del_p.E101fs|CDC20B_uc010ivu.1_Frame_Shift_Del_p.E101fs|CDC20B_uc010ivv.1_Frame_Shift_Del_p.E101fs|CDC20B_uc003jpp.2_RNA	NM_152623	NP_689836	Q86Y33	CD20B_HUMAN	CDC20 cell division cycle 20 homolog B isoform	101_102											0		Lung NSC(810;0.000744)|Breast(144;0.159)|Prostate(74;0.194)	LUSC - Lung squamous cell carcinoma(15;0.225)			TGATCCGGAAGCTTCTGGGAGGTA	0.529		NA									OREG0016610	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	17	60	---	---	---	---	NA	NA	NA	NA
PCDHB3	56132	broad.mit.edu	37	5	140480891	140480891	+	Frame_Shift_Del	DEL	C	C	-			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr5:140480891delC	uc003lio.2	+	1	658	c.658delC	c.(658-660)CCCfs	p.P220fs	uc003lin.2_Intron	NM_018937	NP_061760	Q9Y5E6	PCDB3_HUMAN	protocadherin beta 3 precursor	220	Extracellular (Potential).|Cadherin 2.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			ovary(1)|pancreas(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CGGCGGCTCTCCCCCTCGGTC	0.552		NA											44	30	---	---	---	---	NA	NA	NA	NA
CSMD1	64478	broad.mit.edu	37	8	2820892	2820894	+	In_Frame_Del	DEL	CGG	CGG	-			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr8:2820892_2820894delCGG	uc011kwk.1	-	60	9697_9699	c.9307_9309delCCG	c.(9307-9309)CCGdel	p.P3103del	CSMD1_uc011kwj.1_In_Frame_Del_p.P2432del|CSMD1_uc010lrg.2_In_Frame_Del_p.P994del	NM_033225	NP_150094	Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1 precursor	3103	Sushi 25.|Extracellular (Potential).					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		CATTCTGCACCGGCGGCGGCTGA	0.537		NA											39	177	---	---	---	---	NA	NA	NA	NA
INTS10	55174	broad.mit.edu	37	8	19681415	19681415	+	Frame_Shift_Del	DEL	T	T	-			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr8:19681415delT	uc003wzj.2	+	7	827	c.696delT	c.(694-696)CCTfs	p.P232fs		NM_018142	NP_060612	Q9NVR2	INT10_HUMAN	integrator complex subunit 10	232					snRNA processing	integrator complex	protein binding			ovary(1)	1				Colorectal(111;0.057)|COAD - Colon adenocarcinoma(73;0.215)		TAATGTCACCTAGCAAACGTA	0.403		NA											29	53	---	---	---	---	NA	NA	NA	NA
RP1	6101	broad.mit.edu	37	8	55533949	55533950	+	Frame_Shift_Ins	INS	-	-	G			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr8:55533949_55533950insG	uc003xsd.1	+	2	571_572	c.423_424insG	c.(421-426)CCCGTAfs	p.P141fs	RP1_uc011ldy.1_Frame_Shift_Ins_p.P141fs	NM_006269	NP_006260	P56715	RP1_HUMAN	retinitis pigmentosa RP1 protein	141_142					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			skin(7)|ovary(4)|pancreas(1)	12		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			CGCCCCACCCCGTAGCCGTCGC	0.698		NA											25	64	---	---	---	---	NA	NA	NA	NA
ADAMTS13	11093	broad.mit.edu	37	9	136302011	136302011	+	Frame_Shift_Del	DEL	G	G	-			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr9:136302011delG	uc004cdv.3	+	12	1815	c.1371delG	c.(1369-1371)CCGfs	p.P457fs	ADAMTS13_uc004cdp.3_Intron|ADAMTS13_uc004cdt.1_Frame_Shift_Del_p.P457fs|ADAMTS13_uc004cdu.1_Frame_Shift_Del_p.P426fs|ADAMTS13_uc004cdw.3_Frame_Shift_Del_p.P457fs|ADAMTS13_uc004cdx.3_Frame_Shift_Del_p.P426fs|ADAMTS13_uc004cdy.1_RNA|ADAMTS13_uc004cdz.3_Frame_Shift_Del_p.P127fs|ADAMTS13_uc004cds.1_Intron|ADAMTS13_uc004cdr.1_RNA	NM_139025	NP_620594	Q76LX8	ATS13_HUMAN	ADAM metallopeptidase with thrombospondin type 1	457					cell-matrix adhesion|glycoprotein metabolic process|integrin-mediated signaling pathway|peptide catabolic process|platelet activation|protein processing|proteolysis	cell surface|proteinaceous extracellular matrix	calcium ion binding|integrin binding|metalloendopeptidase activity|zinc ion binding			central_nervous_system(2)|skin(2)|ovary(1)|kidney(1)	6				OV - Ovarian serous cystadenocarcinoma(145;1.06e-07)|Epithelial(140;1.28e-06)|all cancers(34;1.46e-05)		ACGGCCAGCCGCTGCGCTCCT	0.697		NA											5	7	---	---	---	---	NA	NA	NA	NA
KIAA2022	340533	broad.mit.edu	37	X	73962264	73962265	+	Frame_Shift_Ins	INS	-	-	A			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chrX:73962264_73962265insA	uc004eby.2	-	3	2744_2745	c.2127_2128insT	c.(2125-2130)TTTAAGfs	p.F709fs		NM_001008537	NP_001008537	Q5QGS0	K2022_HUMAN	hypothetical protein LOC340533	709_710					base-excision repair, gap-filling|DNA replication proofreading|DNA replication, removal of RNA primer|nucleotide-excision repair, DNA gap filling|regulation of mitotic cell cycle|S phase of mitotic cell cycle	delta DNA polymerase complex	3'-5'-exodeoxyribonuclease activity|DNA-directed DNA polymerase activity			ovary(7)|large_intestine(4)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	15						TCTGGCCCCTTAAACTCTGTGT	0.431		NA											39	26	---	---	---	---	NA	NA	NA	NA