Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	isArtifactMode	oxoGCut
EPHA10	284656	broad.mit.edu	37	1	38184465	38184465	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr1:38184465C>T	uc009vvi.2	-	16	2866	c.2780G>A	c.(2779-2781)CGT>CAT	p.R927H	EPHA10_uc001cbt.2_RNA|EPHA10_uc009vvh.1_RNA|EPHA10_uc001cbu.2_RNA|EPHA10_uc001cbv.1_RNA	NM_001099439	NP_001092909	Q5JZY3	EPHAA_HUMAN	EPH receptor A10 isofom 3	927	Cytoplasmic (Potential).					extracellular region|integral to membrane|integral to plasma membrane	ATP binding|ephrin receptor activity|protein binding|transmembrane-ephrin receptor activity			breast(4)|stomach(3)|lung(1)	8	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				GGAGAAGGCACGGTCCGCTAG	0.677		NA											8	26					0	0	0	0
MACF1	23499	broad.mit.edu	37	1	39905138	39905138	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr1:39905138C>T	uc010oiu.1	+	37	13873	c.13742C>T	c.(13741-13743)CCT>CTT	p.P4581L	MACF1_uc010ois.1_Missense_Mutation_p.P4079L	NM_033044	NP_149033	Q9UPN3	MACF1_HUMAN	microfilament and actin filament cross-linker	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			ovary(8)|breast(3)|central_nervous_system(3)|skin(2)	16	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			GGCATTGATCCTTCCATCATC	0.433		NA											9	62					0	0	0	0
PTPRF	5792	broad.mit.edu	37	1	44075146	44075146	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr1:44075146G>A	uc001cjr.2	+	22	4290	c.3950G>A	c.(3949-3951)CGG>CAG	p.R1317Q	PTPRF_uc001cjs.2_Missense_Mutation_p.R1308Q|PTPRF_uc001cju.2_Missense_Mutation_p.R695Q|PTPRF_uc009vwt.2_Missense_Mutation_p.R877Q|PTPRF_uc001cjv.2_Missense_Mutation_p.R777Q|PTPRF_uc001cjw.2_Missense_Mutation_p.R543Q	NM_002840	NP_002831	P10586	PTPRF_HUMAN	protein tyrosine phosphatase, receptor type, F	1317	Cytoplasmic (Potential).				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			ovary(4)|skin(3)|lung(1)|kidney(1)|central_nervous_system(1)	10	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0333)				GTGGAGATGCGGAGGCTCAAC	0.602		NA											3	42					0	0	0	0
ELAVL4	1996	broad.mit.edu	37	1	50659453	50659453	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr1:50659453C>T	uc001csb.2	+	4	639	c.371C>T	c.(370-372)CCG>CTG	p.P124L	ELAVL4_uc001cry.3_Missense_Mutation_p.P127L|ELAVL4_uc001crz.3_Missense_Mutation_p.P124L|ELAVL4_uc001csa.3_Missense_Mutation_p.P141L|ELAVL4_uc001csc.3_Missense_Mutation_p.P124L|ELAVL4_uc009vyu.2_Missense_Mutation_p.P129L|ELAVL4_uc010omz.1_Missense_Mutation_p.P129L	NM_021952	NP_068771	P26378	ELAV4_HUMAN	ELAV-like 4 isoform 1	124	RRM 1.				mRNA processing		AU-rich element binding|mRNA 3'-UTR binding|nucleotide binding			ovary(1)|pancreas(1)	2						TATGCCCGTCCGAGCTCTGCC	0.507		NA											20	113					0	0	0	0
HOOK1	51361	broad.mit.edu	37	1	60309254	60309254	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr1:60309254C>T	uc009wad.2	+	10	874	c.772C>T	c.(772-774)CAG>TAG	p.Q258*	HOOK1_uc001czo.2_Nonsense_Mutation_p.Q258*|HOOK1_uc001czp.2_RNA|HOOK1_uc010oor.1_Nonsense_Mutation_p.Q216*	NM_015888	NP_056972	Q9UJC3	HOOK1_HUMAN	hook homolog 1	258	Potential.|Sufficient for interaction with microtubules.				early endosome to late endosome transport|endosome organization|endosome to lysosome transport|lysosome organization|microtubule cytoskeleton organization|multicellular organismal development|protein transport	FHF complex|microtubule	identical protein binding			ovary(1)|breast(1)	2	all_cancers(7;0.000129)					AGAACAATTACAGGAAGAAAA	0.328		NA											6	60					0	0	0	0
MTMR11	10903	broad.mit.edu	37	1	149902780	149902780	+	Silent	SNP	C	C	T			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr1:149902780C>T	uc001etl.3	-	14	1619	c.1368G>A	c.(1366-1368)GAG>GAA	p.E456E	SF3B4_uc001etk.1_5'Flank|SF3B4_uc009wll.1_5'Flank|MTMR11_uc001etm.1_Silent_p.E384E|MTMR11_uc010pbm.1_3'UTR|MTMR11_uc010pbn.1_3'UTR	NM_001145862	NP_001139334	A4FU01	MTMRB_HUMAN	myotubularin related protein 11 isoform a	456	Myotubularin phosphatase.						phosphatase activity			central_nervous_system(1)	1	Breast(34;0.0009)|Ovarian(49;0.0377)|all_hematologic(923;0.0597)|Hepatocellular(266;0.161)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.221)|STAD - Stomach adenocarcinoma(528;0.247)			GAAGGAAAAACTCAGAGAATT	0.498		NA											4	86					0	0	0	0
TCHH	7062	broad.mit.edu	37	1	152084677	152084678	+	Missense_Mutation	DNP	AG	AG	TC			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr1:152084677_152084678AG>TC	uc001ezp.2	-	2	1015_1016	c.1015_1016CT>GA	c.(1015-1017)CTG>GAG	p.L339E	TCHH_uc009wne.1_Missense_Mutation_p.L339E	NM_007113	NP_009044	Q07283	TRHY_HUMAN	trichohyalin	339	5 X 13 AA tandem repeats of R-R-E-Q-E-E- E-R-R-E-Q-Q-L.|1-2; approximate.				keratinization	cytoskeleton	calcium ion binding			ovary(3)|kidney(1)|central_nervous_system(1)	5	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			ctcgcgcctcagctgctgctcg	0		NA											3	11					0	0	0	0
OR6K2	81448	broad.mit.edu	37	1	158670019	158670019	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr1:158670019G>T	uc001fsu.1	-	1	424	c.424C>A	c.(424-426)CAA>AAA	p.Q142K		NM_001005279	NP_001005279	Q8NGY2	OR6K2_HUMAN	olfactory receptor, family 6, subfamily K,	142	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(1)	1	all_hematologic(112;0.0378)					AAAGTCAGTTGGGTACATAGC	0.473		NA											8	60					3.1e-07	3.59e-07	1	0
USF1	7391	broad.mit.edu	37	1	161011574	161011574	+	Silent	SNP	C	C	T			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr1:161011574C>T	uc001fxi.2	-	6	534	c.339G>A	c.(337-339)GAG>GAA	p.E113E	F11R_uc010pjw.1_5'Flank|F11R_uc001fxf.3_5'Flank|TSTD1_uc010pjx.1_5'Flank|TSTD1_uc009wtw.2_5'Flank|TSTD1_uc001fxh.3_5'Flank|USF1_uc001fxj.2_Silent_p.E54E	NM_007122	NP_009053	P22415	USF1_HUMAN	upstream stimulatory factor 1 isoform 1	113					cellular response to insulin stimulus|glucose homeostasis|late viral mRNA transcription|lipid homeostasis|positive regulation of transcription from RNA polymerase II promoter by glucose|response to hypoxia|response to UV	transcription factor complex	bHLH transcription factor binding|histone deacetylase binding|protein heterodimerization activity|protein homodimerization activity|protein kinase binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	3	all_cancers(52;6.73e-18)|Breast(13;0.012)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00122)			TATAGTGCGTCTCAGCAGCTG	0.567		NA									OREG0013936	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	17	83					0	0	0	0
SOX13	9580	broad.mit.edu	37	1	204085665	204085665	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr1:204085665T>C	uc001ham.2	+	5	1044	c.449T>C	c.(448-450)CTC>CCC	p.L150P	SOX13_uc001hal.2_Missense_Mutation_p.L150P|SOX13_uc010pqp.1_Missense_Mutation_p.L150P|SOX13_uc010pqq.1_Missense_Mutation_p.L17P	NM_005686	NP_005677	Q9UN79	SOX13_HUMAN	SRY-box 13	150					anatomical structure morphogenesis	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|central_nervous_system(1)	2	all_cancers(21;0.0754)|Breast(84;0.116)|all_epithelial(62;0.189)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.109)			GAGAAGGAGCTCCAGCTTCTG	0.473		NA											19	77					0	0	0	0
USH2A	7399	broad.mit.edu	37	1	215802185	215802185	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr1:215802185C>T	uc001hku.1	-	71	15877	c.15490G>A	c.(15490-15492)GAA>AAA	p.E5164K		NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	5164	Cytoplasmic (Potential).				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		ATGATGGCTTCCCACAGTGAG	0.493		NA								HNSCC(13;0.011)			9	104					0	0	0	0
MLLT10	8028	broad.mit.edu	37	10	21959517	21959517	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr10:21959517G>C	uc001iqs.2	+	10	1283	c.935G>C	c.(934-936)GGG>GCG	p.G312A	MLLT10_uc001iqt.2_Missense_Mutation_p.G312A|MLLT10_uc001iqv.2_RNA|MLLT10_uc001iqy.2_Missense_Mutation_p.G312A|MLLT10_uc001ira.2_5'UTR|MLLT10_uc001iqz.2_Missense_Mutation_p.G67A	NM_004641	NP_004632	P55197	AF10_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	312	DNA-binding.				positive regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(1)|skin(1)	2						GAGACTAGAGGGTCAGAGGGC	0.468		NA	T	MLL|PICALM|CDK6	AL								6	45					0	0	0	0
OR52A4	390053	broad.mit.edu	37	11	5142407	5142407	+	Silent	SNP	C	C	A			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr11:5142407C>A	uc001lzz.1	-	1	402	c.402G>T	c.(400-402)CTG>CTT	p.L134L	OR52A4_uc001maa.2_RNA	NM_001005222	NP_001005222			olfactory receptor, family 52, subfamily A,											ovary(2)	2		Medulloblastoma(188;0.0049)|all_neural(188;0.0442)|Breast(177;0.0675)		Epithelial(150;1.7e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)|LUSC - Lung squamous cell carcinoma(625;0.2)		TAGCACGCCTCAGAGGATAAC	0.473		NA											7	35					0.00198382	0.00213767	1	0
E2F8	79733	broad.mit.edu	37	11	19252273	19252273	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr11:19252273G>A	uc001mpm.2	-	8	1697	c.1175C>T	c.(1174-1176)ACT>ATT	p.T392I	E2F8_uc009yhv.2_Intron|E2F8_uc001mpn.3_Missense_Mutation_p.T392I	NM_024680	NP_078956	A0AVK6	E2F8_HUMAN	E2F family member 8	392					cell cycle	transcription factor complex	DNA binding|sequence-specific DNA binding transcription factor activity			skin(1)	1						TGGGTGTCGAGTAAAGTTTGG	0.423		NA											18	84					0	0	0	0
OR5M1	390168	broad.mit.edu	37	11	56380079	56380079	+	Silent	SNP	G	G	A			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr11:56380079G>A	uc001nja.1	-	1	900	c.900C>T	c.(898-900)GCC>GCT	p.A300A		NM_001004740	NP_001004740	Q8NGP8	OR5M1_HUMAN	olfactory receptor, family 5, subfamily M,	300	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1						TTTGTTGCATGGCAAGGATTA	0.388		NA											37	190					0	0	0	0
OR5B2	390190	broad.mit.edu	37	11	58189994	58189994	+	Silent	SNP	G	G	T	rs150284257		TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr11:58189994G>T	uc010rkg.1	-	1	741	c.741C>A	c.(739-741)TCC>TCA	p.S247S		NM_001005566	NP_001005566	Q96R09	OR5B2_HUMAN	olfactory receptor, family 5, subfamily B,	247	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(3)	3	Esophageal squamous(5;0.0027)	Breast(21;0.0778)				CATAGAAGACGGAGACTGCAG	0.463		NA											9	46					0.000274275	0.000300451	1	0
BRMS1	25855	broad.mit.edu	37	11	66109064	66109064	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr11:66109064C>T	uc001ohp.1	-	3	317	c.170G>A	c.(169-171)CGC>CAC	p.R57H	BRMS1_uc001oho.1_Missense_Mutation_p.R57H|BRMS1_uc009yre.2_5'Flank	NM_015399	NP_056214	Q9HCU9	BRMS1_HUMAN	breast cancer metastasis suppressor 1 isoform 1	57					apoptosis|negative regulation of anti-apoptosis|negative regulation of NF-kappaB transcription factor activity|negative regulation of transcription, DNA-dependent|positive regulation of anoikis|positive regulation of protein deacetylation|transcription, DNA-dependent	cytoplasm|nucleus	NF-kappaB binding				0						ACACTCGCTGCGGCGTCGCTC	0.542		NA											5	278					0	0	0	0
FAM55B	120406	broad.mit.edu	37	11	114569215	114569215	+	Missense_Mutation	SNP	T	T	A			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr11:114569215T>A	uc009yyy.2	+	3	679	c.581T>A	c.(580-582)ATC>AAC	p.I194N		NM_182495	NP_872301	Q96DL1	FA55B_HUMAN	hypothetical protein LOC120406	194						integral to membrane				ovary(1)	1						CTGCTGCTCATCCACCCCAGT	0.542		NA											4	27					0	0	0	0
WNK1	65125	broad.mit.edu	37	12	971429	971429	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr12:971429C>T	uc001qio.3	+	8	2639	c.2132C>T	c.(2131-2133)TCA>TTA	p.S711L	WNK1_uc001qip.3_Missense_Mutation_p.S711L|WNK1_uc001qir.3_Missense_Mutation_p.S158L	NM_018979	NP_061852	Q9H4A3	WNK1_HUMAN	WNK lysine deficient protein kinase 1	711					intracellular protein kinase cascade|ion transport|neuron development	cytoplasm	ATP binding|protein binding|protein kinase inhibitor activity|protein serine/threonine kinase activity			stomach(6)|breast(6)|ovary(5)|lung(4)|large_intestine(1)|central_nervous_system(1)	23	all_cancers(10;0.00611)|all_epithelial(11;0.00825)|all_lung(10;0.0331)|Ovarian(42;0.0512)|Lung NSC(10;0.0632)		Epithelial(1;1.74e-08)|all cancers(1;7.04e-08)|OV - Ovarian serous cystadenocarcinoma(31;0.000423)|BRCA - Breast invasive adenocarcinoma(9;0.0149)|Colorectal(1;0.0197)			TATCCACCCTCAAGTGTGGTA	0.428		NA											17	53					0	0	0	0
ADIPOR2	79602	broad.mit.edu	37	12	1889793	1889793	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr12:1889793C>T	uc001qjm.2	+	5	837	c.640C>T	c.(640-642)CTC>TTC	p.L214F	ADIPOR2_uc001qjn.2_Missense_Mutation_p.L214F	NM_024551	NP_078827	Q86V24	ADR2_HUMAN	adiponectin receptor 2	214	Cytoplasmic (Potential).				fatty acid oxidation|hormone-mediated signaling pathway	integral to membrane	hormone binding|receptor activity				0	Ovarian(42;0.107)		OV - Ovarian serous cystadenocarcinoma(31;0.000382)			GGTCTCTCGGCTCTTCTCTAA	0.428		NA											54	258					0	0	0	0
EFCAB4B	84766	broad.mit.edu	37	12	3788183	3788183	+	Missense_Mutation	SNP	T	T	A			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr12:3788183T>A	uc001qmj.2	-	6	994	c.422A>T	c.(421-423)TAT>TTT	p.Y141F	EFCAB4B_uc010sen.1_Missense_Mutation_p.Y141F|EFCAB4B_uc010seo.1_Missense_Mutation_p.Y141F	NM_032680	NP_116069	Q9BSW2	EFC4B_HUMAN	EF-hand calcium binding domain 4B isoform c	141					activation of store-operated calcium channel activity|store-operated calcium entry	cytoplasm	calcium ion binding|protein binding			ovary(1)|pancreas(1)	2			OV - Ovarian serous cystadenocarcinoma(31;0.00287)|COAD - Colon adenocarcinoma(12;0.0264)			TCTGGACAGATACACCTTCTC	0.557		NA											13	110					0	0	0	0
PLBD1	79887	broad.mit.edu	37	12	14659876	14659876	+	Nonsense_Mutation	SNP	G	G	A	rs145582746		TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr12:14659876G>A	uc001rcc.1	-	9	1524	c.1363C>T	c.(1363-1365)CGA>TGA	p.R455*		NM_024829	NP_079105	Q6P4A8	PLBL1_HUMAN	phospholipase B domain containing 1	455					lipid catabolic process	extracellular region	hydrolase activity				0						CTGTTGTATCGCATGATATAT	0.403		NA											23	112					0	0	0	0
NCKAP1L	3071	broad.mit.edu	37	12	54891638	54891638	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr12:54891638G>T	uc001sgc.3	+	1	144	c.65G>T	c.(64-66)GGT>GTT	p.G22V	NCKAP1L_uc010sox.1_5'UTR|NCKAP1L_uc010soy.1_5'Flank	NM_005337	NP_005328	P55160	NCKPL_HUMAN	NCK-associated protein 1-like	22					actin polymerization-dependent cell motility|B cell homeostasis|B cell receptor signaling pathway|cortical actin cytoskeleton organization|erythrocyte development|maintenance of cell polarity|myeloid cell homeostasis|negative regulation of apoptosis|negative regulation of interleukin-17 production|negative regulation of interleukin-6 production|negative regulation of myosin-light-chain-phosphatase activity|neutrophil chemotaxis|positive regulation of actin filament polymerization|positive regulation of B cell differentiation|positive regulation of B cell proliferation|positive regulation of CD4-positive, alpha-beta T cell differentiation|positive regulation of CD8-positive, alpha-beta T cell differentiation|positive regulation of cell adhesion mediated by integrin|positive regulation of erythrocyte differentiation|positive regulation of gamma-delta T cell differentiation|positive regulation of neutrophil chemotaxis|positive regulation of phagocytosis, engulfment|positive regulation of T cell proliferation|protein complex assembly|response to drug|T cell homeostasis	cytosol|integral to plasma membrane|membrane fraction|SCAR complex	protein complex binding|protein kinase activator activity|Rac GTPase activator activity			ovary(3)|central_nervous_system(1)	4						AATGATCGCGGTCAGGGGGTT	0.453		NA											5	52					1.24e-05	1.4e-05	1	0
MON2	23041	broad.mit.edu	37	12	62954394	62954394	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr12:62954394C>A	uc001sre.2	+	26	3924	c.3533C>A	c.(3532-3534)CCT>CAT	p.P1178H	MON2_uc009zqj.2_Missense_Mutation_p.P1178H|MON2_uc010ssl.1_Missense_Mutation_p.P1106H|MON2_uc010ssm.1_Missense_Mutation_p.P1155H|MON2_uc010ssn.1_Missense_Mutation_p.P1178H|MON2_uc001srf.2_Missense_Mutation_p.P941H|MON2_uc001srg.2_Missense_Mutation_p.P53H	NM_015026	NP_055841	Q7Z3U7	MON2_HUMAN	MON2 homolog	1179					Golgi to endosome transport|protein transport	cytoplasm	ARF guanyl-nucleotide exchange factor activity|binding			central_nervous_system(2)	2			BRCA - Breast invasive adenocarcinoma(9;0.218)	GBM - Glioblastoma multiforme(28;0.128)		ATTGTGTCCCCTGTCAGAGAC	0.448		NA											11	71					0.000673444	0.000734666	1	0
TSPAN8	7103	broad.mit.edu	37	12	71531971	71531971	+	Missense_Mutation	SNP	C	C	A	rs140330026	by1000genomes	TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr12:71531971C>A	uc009zrt.1	-	4	463	c.301G>T	c.(301-303)GCG>TCG	p.A101S	TSPAN8_uc001swk.1_Missense_Mutation_p.A101S|TSPAN8_uc001swj.1_Missense_Mutation_p.A101S	NM_004616	NP_004607	P19075	TSN8_HUMAN	transmembrane 4 superfamily member 3	101	Helical; (Potential).				protein glycosylation	integral to membrane|lysosome	signal transducer activity			skin(2)|lung(1)|central_nervous_system(1)	4			LUSC - Lung squamous cell carcinoma(43;0.24)|OV - Ovarian serous cystadenocarcinoma(12;0.244)			ATACCTGTCGCCACCTGCAGG	0.393		NA											28	144					1.32e-22	1.6e-22	1	0
SCARB1	949	broad.mit.edu	37	12	125270878	125270878	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr12:125270878G>A	uc001ugo.3	-	11	1679	c.1426C>T	c.(1426-1428)CGG>TGG	p.R476W	SCARB1_uc001ugn.3_Intron|SCARB1_uc001ugm.3_Intron|SCARB1_uc010tbd.1_Intron|SCARB1_uc010tbe.1_Missense_Mutation_p.R435W|SCARB1_uc001ugp.3_Missense_Mutation_p.R476W	NM_005505	NP_005496	Q8WTV0	SCRB1_HUMAN	scavenger receptor class B, member 1 isoform 1	476	Cytoplasmic (Potential).				adhesion to symbiont|cell adhesion|cholesterol efflux|cholesterol homeostasis|cholesterol import|detection of lipopolysaccharide|high-density lipoprotein particle clearance|high-density lipoprotein particle remodeling|lipopolysaccharide transport|lipoprotein metabolic process|positive regulation of cholesterol storage|positive regulation of endothelial cell migration|positive regulation of nitric-oxide synthase activity|recognition of apoptotic cell|reverse cholesterol transport|triglyceride homeostasis|wound healing	caveola	1-phosphatidylinositol binding|apolipoprotein A-I binding|high-density lipoprotein particle receptor activity|lipopolysaccharide receptor activity|low-density lipoprotein particle binding|phosphatidylserine binding|transporter activity			kidney(1)	1	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000116)|Epithelial(86;0.000415)|all cancers(50;0.00395)	Phosphatidylserine(DB00144)	CTGTCAGCCCGGGCTGCCCTC	0.667		NA											26	126					0	0	0	0
TPTE2	93492	broad.mit.edu	37	13	20000607	20000607	+	Silent	SNP	A	A	G			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr13:20000607A>G	uc001umd.2	-	19	1564	c.1353T>C	c.(1351-1353)GGT>GGC	p.G451G	TPTE2_uc009zzk.2_Intron|TPTE2_uc009zzl.2_Silent_p.G340G|TPTE2_uc001ume.2_Silent_p.G374G|TPTE2_uc009zzm.2_Silent_p.G122G|TPTE2_uc010tcm.1_RNA|TPTE2_uc010tcl.1_Silent_p.G122G	NM_199254	NP_954863	Q6XPS3	TPTE2_HUMAN	TPTE and PTEN homologous inositol lipid	451	C2 tensin-type.					endoplasmic reticulum membrane|integral to membrane	ion channel activity|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity				0		all_cancers(29;1.23e-20)|all_lung(29;1.97e-20)|all_epithelial(30;5.86e-20)|Lung NSC(5;3.36e-17)|Lung SC(185;0.0262)|Ovarian(182;0.162)		all cancers(112;1.73e-05)|Epithelial(112;7.42e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.000785)|Lung(94;0.0176)|LUSC - Lung squamous cell carcinoma(192;0.089)		ACAGAGGTGGACCGTCATATA	0.338		NA											24	88					0	0	0	0
ZMYM5	9205	broad.mit.edu	37	13	20399104	20399104	+	Missense_Mutation	SNP	T	T	G			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr13:20399104T>G	uc010tcn.1	-	8	1788	c.1523A>C	c.(1522-1524)AAT>ACT	p.N508T	ZMYM5_uc001umm.1_Missense_Mutation_p.N332T	NM_001142684	NP_001136156	Q9UJ78	ZMYM5_HUMAN	zinc finger protein 237 isoform 3	508						nucleus	zinc ion binding				0		all_cancers(29;2.96e-22)|all_epithelial(30;3.76e-20)|all_lung(29;4.38e-20)|Lung NSC(5;5.8e-17)|Lung SC(185;0.0262)|Ovarian(182;0.162)		all cancers(112;1.61e-05)|Epithelial(112;4.89e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00171)|Lung(94;0.00942)|LUSC - Lung squamous cell carcinoma(192;0.0431)		gtcttcaaaatttttctcttc	0		NA											2	14					0	0	0	0
LCP1	3936	broad.mit.edu	37	13	46725072	46725072	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr13:46725072T>C	uc001vaz.3	-	8	1007	c.881A>G	c.(880-882)AAG>AGG	p.K294R	LCP1_uc001vba.3_Missense_Mutation_p.K294R	NM_002298	NP_002289	P13796	PLSL_HUMAN	L-plastin	294	CH 2.|Actin-binding 1.				regulation of intracellular protein transport|T cell activation involved in immune response	cell junction|cytosol|ruffle membrane	calcium ion binding			lung(4)|ovary(3)	7		Lung NSC(96;1.27e-05)|Breast(56;8.04e-05)|Prostate(109;0.00217)|Hepatocellular(98;0.0207)|Lung SC(185;0.0262)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;5.39e-05)		TCCTCCTACCTTGATGTCAGT	0.448		NA	T	BCL6	NHL 								51	99					0	0	0	0
MYO16	23026	broad.mit.edu	37	13	109777522	109777522	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr13:109777522G>A	uc001vqt.1	+	30	3658	c.3532G>A	c.(3532-3534)GTG>ATG	p.V1178M	MYO16_uc010agk.1_Missense_Mutation_p.V1200M|MYO16_uc010tjh.1_Missense_Mutation_p.V690M	NM_015011	NP_055826	Q9Y6X6	MYO16_HUMAN	myosin heavy chain Myr 8	1178					cerebellum development|negative regulation of cell proliferation|negative regulation of S phase of mitotic cell cycle	myosin complex|nucleoplasm|perinuclear region of cytoplasm|plasma membrane	actin filament binding|ATP binding|motor activity			ovary(6)|large_intestine(1)|kidney(1)|breast(1)|central_nervous_system(1)	10	all_lung(23;0.000332)|all_neural(89;0.00294)|Medulloblastoma(90;0.00596)|Lung NSC(43;0.00751)|Lung SC(71;0.104)		BRCA - Breast invasive adenocarcinoma(86;0.19)|all cancers(43;0.201)			ACAACAAGAGGTGACTTCTAT	0.438		NA											17	25					0	0	0	0
C14orf4	64207	broad.mit.edu	37	14	77492316	77492316	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr14:77492316G>A	uc001xsy.2	-	1	2719	c.1820C>T	c.(1819-1821)TCC>TTC	p.S607F		NM_024496	NP_078772	Q9H1B7	I2BPL_HUMAN	chromosome 14 open reading frame 4	607	Pro-rich.					nucleus					0			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.00347)|KIRC - Kidney renal clear cell carcinoma(182;0.0878)		GGTCCGGTTGGAATGGGGTCC	0.517		NA											3	12					0	0	0	0
ASB2	51676	broad.mit.edu	37	14	94413768	94413768	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr14:94413768C>T	uc001ycc.1	-	5	1324	c.835G>A	c.(835-837)GGT>AGT	p.G279S	ASB2_uc001ycd.2_Missense_Mutation_p.G327S|ASB2_uc001yce.1_Missense_Mutation_p.G225S	NM_016150	NP_057234	Q96Q27	ASB2_HUMAN	ankyrin repeat and SOCS box-containing protein	279	ANK 7.				intracellular signal transduction					ovary(1)|pancreas(1)	2		all_cancers(154;0.13)		COAD - Colon adenocarcinoma(157;0.217)|Epithelial(152;0.232)		GCGTCGGCACCCTGTGACAGC	0.612		NA											19	72					0	0	0	0
RTL1	388015	broad.mit.edu	37	14	101349254	101349254	+	Missense_Mutation	SNP	T	T	A			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr14:101349254T>A	uc010txj.1	-	1	1931	c.1872A>T	c.(1870-1872)CAA>CAT	p.Q624H	uc001yig.3_5'Flank|MIR127_hsa-mir-127|MI0000472_5'Flank|MIR432_hsa-mir-432|MI0003133_5'Flank|uc010txk.1_5'Flank|MIR136_hsa-mir-136|MI0000475_5'Flank	NM_001134888	NP_001128360	A6NKG5	RTL1_HUMAN	retrotransposon-like 1	624										pancreas(1)	1						TGGCTCTTTCTTGCATCCTGG	0.547		NA											4	19					0	0	0	0
ZNF770	54989	broad.mit.edu	37	15	35274909	35274909	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr15:35274909C>T	uc001ziw.2	-	3	1038	c.727G>A	c.(727-729)GCT>ACT	p.A243T		NM_014106	NP_054825	Q6IQ21	ZN770_HUMAN	zinc finger protein 770	243					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Lung NSC(122;4.59e-10)|all_lung(180;8.78e-09)		all cancers(64;1.97e-18)|GBM - Glioblastoma multiforme(113;2.11e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0643)		GCCCGAAAAGCCTTATTCCTA	0.363		NA											20	51					0	0	0	0
CREBBP	1387	broad.mit.edu	37	16	3817904	3817904	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr16:3817904C>T	uc002cvv.2	-	16	3271	c.3067G>A	c.(3067-3069)GAG>AAG	p.E1023K	CREBBP_uc002cvw.2_Missense_Mutation_p.E985K	NM_004380	NP_004371	Q92793	CBP_HUMAN	CREB binding protein isoform a	1023					cellular lipid metabolic process|homeostatic process|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|protein complex assembly|response to hypoxia	cytoplasm|nuclear body	histone acetyltransferase activity|MyoD binding|p53 binding|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription coactivator activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(97)|ovary(14)|lung(6)|skin(6)|breast(2)|NS(1)|pancreas(1)	127		Ovarian(90;0.0266)		OV - Ovarian serous cystadenocarcinoma(1;3.54e-05)		AAATCCTCCTCCATCATCTTG	0.388		NA	T|N|F|Mis|O	MLL|MORF|RUNXBP2	ALL|AML|DLBCL|B-NHL 		Rubinstein-Taybi syndrome		Rubinstein-Taybi_syndrome				22	132					0	0	0	0
ACSM5	54988	broad.mit.edu	37	16	20432686	20432686	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr16:20432686C>A	uc002dhe.2	+	5	877	c.730C>A	c.(730-732)CAG>AAG	p.Q244K		NM_017888	NP_060358	Q6NUN0	ACSM5_HUMAN	acyl-CoA synthetase medium-chain family member 5	244					fatty acid metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|GTP binding|metal ion binding			ovary(2)	2						CGAGCACTCCCAGAGCAGCTA	0.423		NA											8	41					5.18e-06	5.89e-06	1	0
SLC5A11	115584	broad.mit.edu	37	16	24921693	24921693	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr16:24921693G>A	uc002dmu.2	+	15	1949	c.1717G>A	c.(1717-1719)GCT>ACT	p.A573T	SLC5A11_uc002dms.2_Missense_Mutation_p.A509T|SLC5A11_uc010vcd.1_Missense_Mutation_p.A538T|SLC5A11_uc002dmt.2_Missense_Mutation_p.A417T|SLC5A11_uc010vce.1_Missense_Mutation_p.A503T|SLC5A11_uc010bxt.2_Missense_Mutation_p.A509T|SLC5A11_uc002dmv.2_Missense_Mutation_p.A196T	NM_052944	NP_443176	Q8WWX8	SC5AB_HUMAN	solute carrier family 5 (sodium/glucose	573	Cytoplasmic (Potential).				apoptosis|carbohydrate transport|sodium ion transport	integral to membrane|plasma membrane	polyol transmembrane transporter activity|symporter activity			ovary(2)	2				GBM - Glioblastoma multiforme(48;0.0365)		ACCACCAGCAGCTCCCTTGTC	0.542		NA											25	119					0	0	0	0
PLA2G15	23659	broad.mit.edu	37	16	68289188	68289188	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr16:68289188C>T	uc002evr.2	+	4	490	c.407C>T	c.(406-408)TCC>TTC	p.S136F	PLA2G15_uc010vld.1_Missense_Mutation_p.S136F|PLA2G15_uc010vle.1_Missense_Mutation_p.P84S|PLA2G15_uc010vlf.1_Intron|PLA2G15_uc002evs.2_5'UTR	NM_012320	NP_036452	Q8NCC3	PAG15_HUMAN	lysophospholipase 3 (lysosomal phospholipase A2)	136					fatty acid catabolic process	extracellular region|lysosome	lysophospholipase activity|phosphatidylcholine-sterol O-acyltransferase activity|phospholipid binding			ovary(1)	1						TCTACAGGTTCCTATTTCCAC	0.557		NA											8	28					0	0	0	0
DHODH	1723	broad.mit.edu	37	16	72057436	72057436	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr16:72057436G>A	uc002fbp.2	+	8	1058	c.1037G>A	c.(1036-1038)CGG>CAG	p.R346Q	DHODH_uc010cgk.2_RNA	NM_001361	NP_001352	Q02127	PYRD_HUMAN	dihydroorotate dehydrogenase precursor	346	Mitochondrial intermembrane (By similarity).		R -> W (in POADS).		'de novo' pyrimidine base biosynthetic process|pyrimidine nucleoside biosynthetic process|UMP biosynthetic process	integral to membrane|mitochondrial inner membrane	dihydroorotate oxidase activity				0		Ovarian(137;0.125)			Atovaquone(DB01117)|Leflunomide(DB01097)	GAGAAGATCCGGGCAGGGGCC	0.607		NA											29	113					0	0	0	0
WFDC1	58189	broad.mit.edu	37	16	84328674	84328674	+	Missense_Mutation	SNP	A	A	T			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr16:84328674A>T	uc002fhw.2	+	1	274	c.97A>T	c.(97-99)AAT>TAT	p.N33Y	WFDC1_uc002fhv.2_Missense_Mutation_p.N33Y	NM_021197	NP_067020	Q9HC57	WFDC1_HUMAN	WAP four-disulfide core domain 1 precursor	33				N -> D (in Ref. 3; BAC11377).	negative regulation of cell growth	extracellular space	serine-type endopeptidase inhibitor activity			breast(1)	1						CTCTGCCAAGAATATCTGGAA	0.632		NA											25	120					0	0	0	0
TP53	7157	broad.mit.edu	37	17	7578271	7578271	+	Missense_Mutation	SNP	T	T	G			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr17:7578271T>G	uc002gim.2	-	6	772	c.578A>C	c.(577-579)CAT>CCT	p.H193P	TP53_uc002gig.1_Missense_Mutation_p.H193P|TP53_uc002gih.2_Missense_Mutation_p.H193P|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.H61P|TP53_uc010cng.1_Missense_Mutation_p.H61P|TP53_uc002gii.1_Missense_Mutation_p.H61P|TP53_uc010cnh.1_Missense_Mutation_p.H193P|TP53_uc010cni.1_Missense_Mutation_p.H193P|TP53_uc002gij.2_Missense_Mutation_p.H193P|TP53_uc010cnj.1_Intron|TP53_uc002gin.2_Missense_Mutation_p.H100P|TP53_uc002gio.2_Missense_Mutation_p.H61P|TP53_uc010vug.1_Missense_Mutation_p.H154P	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	193	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		H -> D (in sporadic cancers; somatic mutation).|H -> Q (in sporadic cancers; somatic mutation).|H -> Y (in sporadic cancers; somatic mutation).|QH -> HN (in a sporadic cancer; somatic mutation).|H -> N (in sporadic cancers; somatic mutation).|QH -> HY (in a sporadic cancer; somatic mutation).|H -> L (in sporadic cancers; somatic mutation).|H -> P (in sporadic cancers; somatic mutation).|H -> R (in LFS; germline mutation and in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.H193R(67)|p.H193L(31)|p.H193Y(26)|p.H193P(12)|p.0?(7)|p.H193D(7)|p.H193N(4)|p.A189_V197delAPPQHLIRV(4)|p.H193fs*16(3)|p.H193H(2)|p.P191fs*53(2)|p.K164_P219del(1)|p.P191fs*15(1)|p.P191fs*6(1)|p.H100L(1)|p.H61L(1)|p.H193_I195delHLI(1)|p.H193_I195>AP(1)|p.A189fs*53(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		TCGGATAAGATGCTGAGGAGG	0.562		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			8	50					0	0	0	0
TP53	7157	broad.mit.edu	37	17	7578395	7578395	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr17:7578395G>A	uc002gim.2	-	5	729	c.535C>T	c.(535-537)CAT>TAT	p.H179Y	TP53_uc002gig.1_Missense_Mutation_p.H179Y|TP53_uc002gih.2_Missense_Mutation_p.H179Y|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.H47Y|TP53_uc010cng.1_Missense_Mutation_p.H47Y|TP53_uc002gii.1_Missense_Mutation_p.H47Y|TP53_uc010cnh.1_Missense_Mutation_p.H179Y|TP53_uc010cni.1_Missense_Mutation_p.H179Y|TP53_uc002gij.2_Missense_Mutation_p.H179Y|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.H86Y|TP53_uc002gio.2_Missense_Mutation_p.H47Y|TP53_uc010vug.1_Missense_Mutation_p.H140Y	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	179	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).	Zinc.	H -> Q (in sporadic cancers; somatic mutation).|H -> N (in sporadic cancers; somatic mutation).|H -> R (in sporadic cancers; somatic mutation).|HH -> QS (in a sporadic cancer; somatic mutation).|H -> L (in sporadic cancers; somatic mutation).|H -> D (in sporadic cancers; somatic mutation).|H -> P (in sporadic cancers; somatic mutation).|H -> Y (in LFS; germline mutation and in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.H179R(99)|p.H179Y(74)|p.H179L(31)|p.H179Q(17)|p.H179N(13)|p.H179D(10)|p.P177_C182delPHHERC(8)|p.0?(7)|p.C176_R181delCPHHER(3)|p.R174fs*24(3)|p.H179P(3)|p.R175_E180delRCPHHE(3)|p.H179fs*68(2)|p.H179H(2)|p.P177fs*3(2)|p.V173fs*59(2)|p.R174fs*1(2)|p.K164_P219del(1)|p.C176fs*65(1)|p.C176fs*68(1)|p.P177_H179delPHH(1)|p.V173fs*23(1)|p.V172_E180delVVRRCPHHE(1)|p.R174_H179delRRCPHH(1)|p.E171fs*1(1)|p.H179del(1)|p.E171_H179delEVVRRCPHH(1)|p.R81fs*24(1)|p.R174_E180>K(1)|p.H178fs*6(1)|p.P177_E180delPHHE(1)|p.R42fs*24(1)|p.R174fs*3(1)|p.H178_H179>QY(1)|p.E171fs*61(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CAGCGCTCATGGTGGGGGCAG	0.642		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			15	58					0	0	0	0
CCDC42	146849	broad.mit.edu	37	17	8638565	8638565	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr17:8638565C>T	uc002gln.2	-	6	949	c.722G>A	c.(721-723)CGC>CAC	p.R241H	CCDC42_uc002glo.2_Missense_Mutation_p.R167H	NM_144681	NP_653282	Q96M95	CCD42_HUMAN	coiled-coil domain containing 42 isoform 1	241										ovary(1)	1						GTGCGCCCAGCGAGATTCCTG	0.473		NA											5	56					0	0	0	0
MYH4	4622	broad.mit.edu	37	17	10351237	10351237	+	Silent	SNP	C	C	T			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr17:10351237C>T	uc002gmn.2	-	34	4974	c.4863G>A	c.(4861-4863)AAG>AAA	p.K1621K	uc002gml.1_Intron	NM_017533	NP_060003	Q9Y623	MYH4_HUMAN	myosin, heavy polypeptide 4, skeletal muscle	1621	Potential.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(10)|skin(2)|central_nervous_system(1)	13						CTCCCTCCATCTTCTTCTTGA	0.458		NA											9	278					0	0	0	0
MYOCD	93649	broad.mit.edu	37	17	12639605	12639605	+	Silent	SNP	C	C	T			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr17:12639605C>T	uc002gnn.2	+	6	842	c.543C>T	c.(541-543)GAC>GAT	p.D181D	MYOCD_uc002gno.2_Silent_p.D181D|MYOCD_uc002gnp.1_Silent_p.D85D	NM_153604	NP_705832	Q8IZQ8	MYCD_HUMAN	myocardin isoform 2	181	HDAC5-binding (By similarity).				cardiac muscle cell differentiation|negative regulation of cell proliferation|negative regulation of cyclin-dependent protein kinase activity|positive regulation of smooth muscle cell differentiation|positive regulation of smooth muscle contraction|positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation|regulation of histone acetylation|smooth muscle cell differentiation	nucleus	nucleic acid binding|RNA polymerase II transcription factor binding transcription factor activity|transcription factor binding			central_nervous_system(2)|skin(2)|ovary(1)	5				UCEC - Uterine corpus endometrioid carcinoma (92;0.0969)		CCCCGCCAGACGCTAAAGCCT	0.488		NA											26	119					0	0	0	0
IMP5	162540	broad.mit.edu	37	17	43923368	43923368	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr17:43923368C>T	uc010wka.1	+	1	1096	c.1096C>T	c.(1096-1098)CGT>TGT	p.R366C	LOC100128977_uc010wjz.1_Intron	NM_175882	NP_787078	Q8IUH8	IMP5_HUMAN	intramembrane protease 5 precursor	366	Extracellular (Potential).					integral to membrane	aspartic-type endopeptidase activity			pancreas(2)	2	Colorectal(2;0.0416)			BRCA - Breast invasive adenocarcinoma(366;0.148)		CGTCCTGCACCGTGTGCGGCT	0.582		NA											13	34					0	0	0	0
CACNA1G	8913	broad.mit.edu	37	17	48699100	48699100	+	Missense_Mutation	SNP	A	A	T			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr17:48699100A>T	uc002irk.1	+	35	6377	c.6005A>T	c.(6004-6006)GAT>GTT	p.D2002V	CACNA1G_uc002irj.1_Intron|CACNA1G_uc002irl.1_Intron|CACNA1G_uc002irm.1_Intron|CACNA1G_uc002irn.1_Intron|CACNA1G_uc002iro.1_Intron|CACNA1G_uc002irp.1_Intron|CACNA1G_uc002irq.1_Missense_Mutation_p.D1979V|CACNA1G_uc002irr.1_Intron|CACNA1G_uc002irs.1_Intron|CACNA1G_uc002irt.1_Intron|CACNA1G_uc002irv.1_Intron|CACNA1G_uc002irw.1_Missense_Mutation_p.D1931V|CACNA1G_uc002iru.1_Missense_Mutation_p.D1968V|CACNA1G_uc002irx.1_Intron|CACNA1G_uc002iry.1_Intron|CACNA1G_uc002irz.1_Intron|CACNA1G_uc002isa.1_Intron|CACNA1G_uc002isb.1_Intron|CACNA1G_uc002isc.1_Missense_Mutation_p.D1904V|CACNA1G_uc002isd.1_Intron|CACNA1G_uc002ise.1_Intron|CACNA1G_uc002isf.1_Intron|CACNA1G_uc002isg.1_Intron|CACNA1G_uc002ish.1_Intron|CACNA1G_uc002isi.1_Intron	NM_018896	NP_061496	O43497	CAC1G_HUMAN	voltage-dependent calcium channel alpha 1G	2002	Cytoplasmic (Potential).				axon guidance	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(1)	1	Breast(11;6.7e-17)		BRCA - Breast invasive adenocarcinoma(22;7.52e-09)		Ethosuximide(DB00593)|Flunarizine(DB04841)|Levetiracetam(DB01202)|Mibefradil(DB01388)|Pimozide(DB01100)|Trimethadione(DB00347)|Verapamil(DB00661)|Zonisamide(DB00909)	GCTCTGACGGATGACTCTTTG	0.547		NA											5	67					0	0	0	0
DLGAP1	9229	broad.mit.edu	37	18	3880018	3880018	+	Silent	SNP	G	G	A			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr18:3880018G>A	uc002kmf.2	-	1	118	c.51C>T	c.(49-51)GAC>GAT	p.D17D	DLGAP1_uc010wyz.1_Silent_p.D17D|DLGAP1_uc002kmk.2_Silent_p.D17D|uc002kml.1_Intron	NM_004746	NP_004737	O14490	DLGP1_HUMAN	discs large homolog-associated protein 1 isoform	17					synaptic transmission	cell junction|postsynaptic density|postsynaptic membrane				ovary(2)|pancreas(1)|skin(1)	4		Colorectal(8;0.0257)				CACAGGCCGAGTCGCAGGTGA	0.662		NA											14	27					0	0	0	0
CHST9	83539	broad.mit.edu	37	18	24496367	24496367	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr18:24496367C>G	uc002kwd.2	-	5	1386	c.1188G>C	c.(1186-1188)AAG>AAC	p.K396N	C18orf16_uc002kwb.2_Intron|C18orf16_uc010xbm.1_Intron|CHST9_uc002kwc.2_Missense_Mutation_p.K311N|CHST9_uc002kwe.2_Missense_Mutation_p.K396N	NM_031422	NP_113610	Q7L1S5	CHST9_HUMAN	GalNAc-4-sulfotransferase 2	396	Lumenal (Potential).				carbohydrate biosynthetic process|glycosaminoglycan metabolic process|hormone biosynthetic process|proteoglycan biosynthetic process|sulfur compound metabolic process	extracellular region|Golgi membrane|integral to membrane	N-acetylgalactosamine 4-O-sulfotransferase activity			ovary(2)|skin(1)	3	all_lung(6;0.0145)|Ovarian(20;0.124)					AGTGCCTATCCTTAAAGTTGG	0.368		NA											47	165					0	0	0	0
CPLX4	339302	broad.mit.edu	37	18	56963955	56963955	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr18:56963955G>A	uc002lhy.2	-	3	645	c.458C>T	c.(457-459)GCG>GTG	p.A153V		NM_181654	NP_857637	Q7Z7G2	CPLX4_HUMAN	complexin 4 precursor	153					exocytosis|neurotransmitter transport	cell junction|synapse	syntaxin binding			ovary(1)	1		Colorectal(73;0.175)				CTTCTGCTCCGCTGTCTGCTT	0.498		NA											13	60					0	0	0	0
INSR	3643	broad.mit.edu	37	19	7122639	7122639	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr19:7122639G>A	uc002mgd.1	-	19	3624	c.3515C>T	c.(3514-3516)ACT>ATT	p.T1172I	INSR_uc002mge.1_Missense_Mutation_p.T1160I	NM_000208	NP_000199	P06213	INSR_HUMAN	insulin receptor isoform Long precursor	1172	Protein kinase.|Cytoplasmic (Potential).				activation of MAPK activity|activation of protein kinase B activity|carbohydrate metabolic process|fibroblast growth factor receptor signaling pathway|G-protein coupled receptor protein signaling pathway|glucose homeostasis|heart morphogenesis|peptidyl-tyrosine phosphorylation|positive regulation of cell migration|positive regulation of cell proliferation|positive regulation of developmental growth|positive regulation of DNA replication|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of glycolysis|positive regulation of MAPKKK cascade|positive regulation of mitosis|positive regulation of nitric oxide biosynthetic process|positive regulation of protein kinase B signaling cascade|positive regulation of protein phosphorylation|positive regulation of respiratory burst|protein autophosphorylation|protein heterotetramerization|regulation of embryonic development|regulation of transcription, DNA-dependent|transformation of host cell by virus	caveola|endosome membrane|insulin receptor complex|microsome	ATP binding|GTP binding|insulin binding|insulin receptor activity|insulin receptor substrate binding|insulin-like growth factor I binding|insulin-like growth factor II binding|insulin-like growth factor receptor binding|metal ion binding|phosphatidylinositol 3-kinase binding|PTB domain binding|receptor signaling protein tyrosine kinase activity|SH2 domain binding			ovary(4)|lung(3)|central_nervous_system(2)|large_intestine(1)|stomach(1)|skin(1)	12					Insulin Glargine recombinant(DB00047)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	AATTTTGACAGTAAAATCATG	0.488		NA											3	94					0	0	0	0
MUC16	94025	broad.mit.edu	37	19	9056421	9056421	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr19:9056421G>A	uc002mkp.2	-	3	31229	c.31025C>T	c.(31024-31026)TCT>TTT	p.S10342F		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	10344	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GATGGTTGAAGAATCAGTGGT	0.532		NA											20	54					0	0	0	0
CYP4F11	57834	broad.mit.edu	37	19	16038133	16038133	+	Silent	SNP	C	C	A			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr19:16038133C>A	uc002nbu.2	-	5	450	c.414G>T	c.(412-414)CTG>CTT	p.L138L	CYP4F11_uc010eab.1_Silent_p.L138L|CYP4F11_uc002nbt.2_Silent_p.L138L	NM_001128932	NP_001122404	Q9HBI6	CP4FB_HUMAN	cytochrome P450 family 4 subfamily F polypeptide	138					inflammatory response|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	aromatase activity|electron carrier activity|heme binding			ovary(1)	1						CACCACCACTCAGCAGGAGCC	0.527		NA											21	102					0.00229938	0.00246762	1	0
TSHZ3	57616	broad.mit.edu	37	19	31768676	31768676	+	Missense_Mutation	SNP	G	G	A	rs143305127		TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr19:31768676G>A	uc002nsy.3	-	2	2088	c.2023C>T	c.(2023-2025)CGG>TGG	p.R675W		NM_020856	NP_065907	Q63HK5	TSH3_HUMAN	zinc finger protein 537	675					negative regulation of transcription, DNA-dependent|regulation of respiratory gaseous exchange by neurological system process	growth cone|nucleus	chromatin binding|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)|skin(2)|pancreas(1)|lung(1)	8	Esophageal squamous(110;0.226)					CACCCATCCCGCGGGGGGCTG	0.652		NA											15	56					0	0	0	0
TFPT	29844	broad.mit.edu	37	19	54613495	54613495	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr19:54613495G>A	uc010yej.1	-	3	698	c.292C>T	c.(292-294)CGG>TGG	p.R98W	TFPT_uc010erd.2_Missense_Mutation_p.R98W	NM_013342	NP_037474	P0C1Z6	TFPT_HUMAN	TCF3 (E2A) fusion partner	98					apoptosis|DNA recombination|DNA repair|induction of apoptosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|Ino80 complex	DNA binding|protein binding				0	all_cancers(19;0.004)|all_epithelial(19;0.00195)|all_lung(19;0.0193)|Lung NSC(19;0.0358)|Breast(117;0.137)|Ovarian(34;0.19)					TTCAGGACCCGCTCGTTCACC	0.577		NA	T	TCF3	pre-B ALL								11	39					0	0	0	0
SNTG2	54221	broad.mit.edu	37	2	1263157	1263157	+	Missense_Mutation	SNP	T	T	G			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr2:1263157T>G	uc002qwq.2	+	13	1149	c.1021T>G	c.(1021-1023)TGG>GGG	p.W341G	SNTG2_uc010ewi.2_Missense_Mutation_p.W214G	NM_018968	NP_061841	Q9NY99	SNTG2_HUMAN	syntrophin, gamma 2	341	PH.				central nervous system development	cytoplasm|cytoskeleton|sarcolemma|syntrophin complex	actin binding|PDZ domain binding			ovary(1)|large_intestine(1)|breast(1)	3	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.00469)		all cancers(51;0.0178)|OV - Ovarian serous cystadenocarcinoma(76;0.07)|Epithelial(75;0.0864)|GBM - Glioblastoma multiforme(21;0.173)		CACATTCGATTGGGTGCGAGC	0.383		NA											12	92					0	0	0	0
KCNH7	90134	broad.mit.edu	37	2	163374452	163374452	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr2:163374452G>A	uc002uch.1	-	4	892	c.680C>T	c.(679-681)CCC>CTC	p.P227L	KCNH7_uc002uci.2_Missense_Mutation_p.P227L	NM_033272	NP_150375	Q9NS40	KCNH7_HUMAN	potassium voltage-gated channel, subfamily H,	227	Cytoplasmic (Potential).				regulation of transcription, DNA-dependent	integral to membrane	protein binding|signal transducer activity			ovary(3)|skin(2)	5					Ibutilide(DB00308)	ATTCACCAAGGGAGAACATTT	0.483		NA											11	134					0	0	0	0
FIGN	55137	broad.mit.edu	37	2	164467456	164467456	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr2:164467456G>A	uc002uck.1	-	3	1197	c.886C>T	c.(886-888)CAG>TAG	p.Q296*		NM_018086	NP_060556	Q5HY92	FIGN_HUMAN	fidgetin	296						nuclear matrix	ATP binding|nucleoside-triphosphatase activity			large_intestine(2)|ovary(1)|skin(1)	4						CCATGGCCCTGGTAGGTGTAG	0.577		NA											8	78					0	0	0	0
SCN9A	6335	broad.mit.edu	37	2	167055551	167055551	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr2:167055551C>A	uc010fpl.2	-	27	5906	c.5565G>T	c.(5563-5565)AGG>AGT	p.R1855S	uc002udp.2_Intron	NM_002977	NP_002968	Q15858	SCN9A_HUMAN	sodium channel, voltage-gated, type IX, alpha	1866						voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|central_nervous_system(5)|skin(2)	13					Lamotrigine(DB00555)|Lidocaine(DB00281)	CAGACATGAACCTTTCTTCCA	0.443		NA											13	117					0.00136819	0.00148643	1	0
TTN	7273	broad.mit.edu	37	2	179435645	179435645	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr2:179435645C>G	uc010zfg.1	-	275	67734	c.67510G>C	c.(67510-67512)GTT>CTT	p.V22504L	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.V16199L|TTN_uc010zfi.1_Missense_Mutation_p.V16132L|TTN_uc010zfj.1_Missense_Mutation_p.V16007L	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	23431							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TGATCTTCAACTAGGCCAGTT	0.418		NA											37	158					0	0	0	0
NRP2	8828	broad.mit.edu	37	2	206628571	206628571	+	Missense_Mutation	SNP	A	A	G			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr2:206628571A>G	uc002vaw.2	+	13	3009	c.2218A>G	c.(2218-2220)AGC>GGC	p.S740G	NRP2_uc002vau.2_Missense_Mutation_p.S740G|NRP2_uc002vav.2_Missense_Mutation_p.S740G|NRP2_uc002vax.2_Missense_Mutation_p.S740G|NRP2_uc002vay.2_Missense_Mutation_p.S740G	NM_201266	NP_957718	O60462	NRP2_HUMAN	neuropilin 2 isoform 1 precursor	740	Extracellular (Potential).|MAM.				angiogenesis|axon guidance|cell adhesion	integral to membrane|membrane fraction|plasma membrane	heparin binding|metal ion binding|semaphorin receptor activity|vascular endothelial growth factor receptor activity			skin(2)|ovary(1)|central_nervous_system(1)	4						CAGCCAGGAGAGCAAGTTGCT	0.677		NA									OREG0015155	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	10	69					0	0	0	0
PTPRN	5798	broad.mit.edu	37	2	220162103	220162103	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr2:220162103C>T	uc002vkz.2	-	14	2029	c.1940G>A	c.(1939-1941)GGT>GAT	p.G647D	PTPRN_uc010zlc.1_Missense_Mutation_p.G557D|PTPRN_uc002vla.2_Missense_Mutation_p.G618D	NM_002846	NP_002837	Q16849	PTPRN_HUMAN	protein tyrosine phosphatase, receptor type, N	647	Cytoplasmic (Potential).				response to reactive oxygen species	integral to plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			ovary(2)|lung(1)|skin(1)	4		Renal(207;0.0474)		Epithelial(149;4.22e-07)|all cancers(144;8.82e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)|STAD - Stomach adenocarcinoma(1183;0.0875)		CTCCGGTGGACCCTCTGCCCG	0.632		NA											12	71					0	0	0	0
EPHA4	2043	broad.mit.edu	37	2	222429107	222429107	+	Missense_Mutation	SNP	T	T	G			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr2:222429107T>G	uc002vmq.2	-	3	209	c.167A>C	c.(166-168)GAA>GCA	p.E56A	EPHA4_uc002vmr.2_Missense_Mutation_p.E56A|EPHA4_uc010zlm.1_5'UTR|EPHA4_uc010zln.1_Missense_Mutation_p.E56A	NM_004438	NP_004429	P54764	EPHA4_HUMAN	ephrin receptor EphA4 precursor	56	Extracellular (Potential).					integral to plasma membrane	ATP binding|ephrin receptor activity			lung(6)|large_intestine(2)|central_nervous_system(2)|urinary_tract(1)|skin(1)	12		Renal(207;0.0183)		Epithelial(121;5.38e-09)|all cancers(144;2.47e-06)|LUSC - Lung squamous cell carcinoma(224;0.0115)|Lung(261;0.0154)		GATACTCACTTCCTCCCACTG	0.403		NA											30	118					0	0	0	0
C20orf79	140856	broad.mit.edu	37	20	18794840	18794840	+	Silent	SNP	G	G	A			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr20:18794840G>A	uc002wrk.2	+	1	471	c.381G>A	c.(379-381)AAG>AAA	p.K127K	uc002wrj.1_Intron	NM_178483	NP_848578	Q9UJQ7	CT079_HUMAN	hypothetical protein LOC140856	127	SCP2.						sterol binding			skin(3)	3						ACCCGCAGAAGGCTTTCCTTG	0.483		NA											24	82					0	0	0	0
MYO18B	84700	broad.mit.edu	37	22	26168444	26168444	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr22:26168444G>T	uc003abz.1	+	7	2086	c.1836G>T	c.(1834-1836)CAG>CAT	p.Q612H	MYO18B_uc003aca.1_Missense_Mutation_p.Q493H|MYO18B_uc010guy.1_Missense_Mutation_p.Q493H|MYO18B_uc010guz.1_Missense_Mutation_p.Q493H|MYO18B_uc011aka.1_5'UTR|MYO18B_uc011akb.1_Missense_Mutation_p.Q125H	NM_032608	NP_115997	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	612	Myosin head-like.					nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			ovary(5)|central_nervous_system(3)|large_intestine(2)|breast(2)	12						TTGTCCTCCAGCCCCGGGGGC	0.637		NA											7	37					2.01e-06	2.3e-06	1	0
PES1	23481	broad.mit.edu	37	22	30976074	30976074	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr22:30976074C>T	uc003aij.1	-	11	1209	c.1135G>A	c.(1135-1137)GAC>AAC	p.D379N	PES1_uc003aik.1_Missense_Mutation_p.D374N|PES1_uc003ail.1_Missense_Mutation_p.D362N|PES1_uc003aim.1_Missense_Mutation_p.D379N|PES1_uc003ain.1_Missense_Mutation_p.D240N|PES1_uc003aio.1_Missense_Mutation_p.D240N	NM_014303	NP_055118	O00541	PESC_HUMAN	pescadillo homolog 1, containing BRCT domain	379	Sufficient for interaction with MAP1B (By similarity).|BRCT.				cell proliferation|maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|regulation of cell cycle	chromosome|nucleoplasm|PeBoW complex|preribosome, large subunit precursor	protein binding				0						CCAGGCCGGTCGACAATCTGA	0.572		NA											31	129					0	0	0	0
TXN2	25828	broad.mit.edu	37	22	36876729	36876729	+	Missense_Mutation	SNP	T	T	C	rs146269725	by1000genomes	TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr22:36876729T>C	uc003apk.1	-	2	233	c.156A>G	c.(154-156)ATA>ATG	p.I52M	TXN2_uc003apl.1_RNA	NM_012473	NP_036605	Q99757	THIOM_HUMAN	thioredoxin 2 precursor	52					cell redox homeostasis|electron transport chain|glycerol ether metabolic process|transport	mitochondrion|nucleolus	electron carrier activity				0						TCGTGGTGTATATTGTCCGGG	0.547		NA											24	89					0	0	0	0
TRANK1	9881	broad.mit.edu	37	3	36899181	36899181	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr3:36899181G>A	uc003cgj.2	-	3	552	c.250C>T	c.(250-252)CAG>TAG	p.Q84*		NM_014831	NP_055646	O15050	TRNK1_HUMAN	lupus brain antigen 1	634					DNA repair		ATP binding|ATP-dependent DNA helicase activity|DNA binding			ovary(1)|central_nervous_system(1)	2						GACTTGAGCTGAGATGTGTGA	0.582		NA											23	102					0	0	0	0
ITGA9	3680	broad.mit.edu	37	3	37818922	37818922	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr3:37818922C>T	uc003chd.2	+	24	2634	c.2581C>T	c.(2581-2583)CCA>TCA	p.P861S		NM_002207	NP_002198	Q13797	ITA9_HUMAN	integrin, alpha 9 precursor	861	Extracellular (Potential).				axon guidance|cell adhesion|integrin-mediated signaling pathway	integrin complex	receptor activity			breast(3)|pancreas(1)|lung(1)|skin(1)	6				KIRC - Kidney renal clear cell carcinoma(284;0.165)|Kidney(284;0.197)		CCAGAAAAACCCAACTCCCTG	0.413		NA											8	49					0	0	0	0
SCN10A	6336	broad.mit.edu	37	3	38793780	38793780	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr3:38793780G>T	uc003ciq.2	-	11	1685	c.1685C>A	c.(1684-1686)TCC>TAC	p.S562Y		NM_006514	NP_006505	Q9Y5Y9	SCNAA_HUMAN	sodium channel, voltage-gated, type X, alpha	562					sensory perception	voltage-gated sodium channel complex				ovary(5)|skin(3)|large_intestine(1)|kidney(1)	10				KIRC - Kidney renal clear cell carcinoma(284;0.0769)|Kidney(284;0.0945)	Benzocaine(DB01086)|Bupivacaine(DB00297)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dibucaine(DB00527)|Dyclonine(DB00645)|Hexylcaine(DB00473)|Levobupivacaine(DB01002)|Lidocaine(DB00281)|Mepivacaine(DB00961)|Oxybuprocaine(DB00892)|Procaine(DB00721)|Proparacaine(DB00807)|Ropivacaine(DB00296)	TCCATGCCTGGAGTCAGGGTT	0.607		NA											24	76					7.08e-08	8.27e-08	1	0
CRYBG3	131544	broad.mit.edu	37	3	97662106	97662106	+	Missense_Mutation	SNP	A	A	G			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr3:97662106A>G	uc003drx.2	+	19	3081	c.3017A>G	c.(3016-3018)AAT>AGT	p.N1006S	CRYBG3_uc010hoz.1_RNA|MINA_uc003dry.1_3'UTR|MINA_uc003drz.1_3'UTR|MINA_uc003dsa.1_3'UTR|MINA_uc003dsb.1_3'UTR|MINA_uc003dsc.1_3'UTR	NM_153605	NP_705833			beta-gamma crystallin domain containing 3												0						GTAATTGTAAATCAGCCCCTG	0.308		NA											17	41					0	0	0	0
SLC7A14	57709	broad.mit.edu	37	3	170198588	170198588	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr3:170198588G>T	uc003fgz.2	-	7	1799	c.1483C>A	c.(1483-1485)CTC>ATC	p.L495I	CLDN11_uc011bpt.1_Intron|uc003fha.1_Intron	NM_020949	NP_066000	Q8TBB6	S7A14_HUMAN	solute carrier family 7 (cationic amino acid	495						integral to membrane	amino acid transmembrane transporter activity			ovary(2)|upper_aerodigestive_tract(1)|liver(1)|central_nervous_system(1)	5	all_cancers(22;2.41e-22)|all_epithelial(15;4.2e-27)|all_lung(20;1.17e-16)|Lung NSC(18;4.91e-16)|Ovarian(172;0.000902)|Breast(254;0.137)		Lung(28;6.23e-13)|LUSC - Lung squamous cell carcinoma(14;1.48e-12)			TTCCCTATGAGCATCTCATTG	0.498		NA											38	257					2.05e-20	2.47e-20	1	0
SEL1L3	23231	broad.mit.edu	37	4	25783863	25783863	+	Splice_Site	SNP	C	C	T			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr4:25783863C>T	uc003gru.3	-	15	2609	c.2457_splice	c.e15+1	p.Q819_splice	SEL1L3_uc003grv.2_Splice_Site_p.Q226_splice	NM_015187	NP_056002	Q68CR1	SE1L3_HUMAN	sel-1 suppressor of lin-12-like 3							integral to membrane	binding				0						GTCCTACTCACTTGATTCCTT	0.483		NA											34	167					0	0	0	0
TERT	7015	broad.mit.edu	37	5	1294259	1294259	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr5:1294259G>A	uc003jcb.1	-	2	800	c.742C>T	c.(742-744)CGG>TGG	p.R248W	TERT_uc003jca.1_Missense_Mutation_p.R248W|TERT_uc003jcc.1_Missense_Mutation_p.R248W|TERT_uc003jcd.1_RNA|TERT_uc003jce.1_RNA	NM_198253	NP_937983	O14746	TERT_HUMAN	telomerase reverse transcriptase isoform 1	248	Linker.				anti-apoptosis|DNA strand elongation|replicative senescence|telomere formation via telomerase|telomere maintenance via telomerase	cytoplasm|nucleolus|PML body|telomerase holoenzyme complex	protein homodimerization activity|telomeric DNA binding|telomeric RNA binding|telomeric template RNA reverse transcriptase activity			lung(7)|ovary(2)|central_nervous_system(2)|skin(1)	12	all_cancers(3;3.17e-16)|Lung NSC(6;8.55e-15)|all_lung(6;7.2e-14)|all_epithelial(6;1.87e-10)		Epithelial(17;0.00105)|all cancers(22;0.00178)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|Lung(60;0.185)			ACGGGCGTCCGCTCCGGCTCA	0.736		NA							TERT_Mutation-Associated_Haematological_Disorders|Congenital_Dyskeratosis|Pulmonary_Fibrosis_Idiopathic				3	8					0	0	0	0
KIAA0947	23379	broad.mit.edu	37	5	5461594	5461594	+	Missense_Mutation	SNP	A	A	T			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr5:5461594A>T	uc003jdm.3	+	13	2369	c.2147A>T	c.(2146-2148)AAT>ATT	p.N716I		NM_015325	NP_056140	Q9Y2F5	K0947_HUMAN	hypothetical protein LOC23379	716										ovary(1)|central_nervous_system(1)	2						TCTAATTTTAATGATCAGAAG	0.398		NA											22	36					0	0	0	0
DNAH5	1767	broad.mit.edu	37	5	13807734	13807734	+	Missense_Mutation	SNP	T	T	A			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr5:13807734T>A	uc003jfd.2	-	47	7895	c.7853A>T	c.(7852-7854)AAT>ATT	p.N2618I		NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	2618	AAA 3 (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					AGAAGAAAAATTCAGACTCTT	0.388		NA							Kartagener_syndrome				7	24					0	0	0	0
ANKH	56172	broad.mit.edu	37	5	14716935	14716935	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr5:14716935C>T	uc003jfm.3	-	9	1352	c.1021G>A	c.(1021-1023)GTG>ATG	p.V341M	ANKH_uc003jfl.3_Missense_Mutation_p.V54M	NM_054027	NP_473368	Q9HCJ1	ANKH_HUMAN	progressive ankylosis protein	341	Helical; (Potential).				locomotory behavior|regulation of bone mineralization|skeletal system development	integral to plasma membrane|outer membrane	inorganic diphosphate transmembrane transporter activity|inorganic phosphate transmembrane transporter activity			upper_aerodigestive_tract(1)	1						CAAAACATCACGAAACAGAGC	0.453		NA											4	33					0	0	0	0
CDH10	1008	broad.mit.edu	37	5	24511576	24511576	+	Missense_Mutation	SNP	T	T	A			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr5:24511576T>A	uc003jgr.1	-	6	1194	c.862A>T	c.(862-864)ATT>TTT	p.I288F	CDH10_uc011cnu.1_RNA	NM_006727	NP_006718	Q9Y6N8	CAD10_HUMAN	cadherin 10, type 2 preproprotein	288	Cadherin 3.|Extracellular (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(6)|pancreas(4)|breast(2)	12				STAD - Stomach adenocarcinoma(35;0.0556)		ACACTTCCAATGGCTGTGCCA	0.343		NA								HNSCC(23;0.051)			38	72					0	0	0	0
AQPEP	206338	broad.mit.edu	37	5	115298653	115298653	+	Silent	SNP	G	G	A			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr5:115298653G>A	uc003kro.2	+	1	503	c.339G>A	c.(337-339)CCG>CCA	p.P113P	AQPEP_uc003krp.2_RNA|uc003krn.1_5'UTR	NM_173800	NP_776161	Q6Q4G3	AMPQ_HUMAN	laeverin	113	Lumenal (Potential).				proteolysis	integral to membrane	metallopeptidase activity|zinc ion binding				0						AGCTGTGGCCGCAGCTGAGGC	0.701		NA											6	79					0	0	0	0
PDE6A	5145	broad.mit.edu	37	5	149265901	149265901	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr5:149265901C>T	uc003lrg.3	-	14	1885	c.1765G>A	c.(1765-1767)GCC>ACC	p.A589T		NM_000440	NP_000431	P16499	PDE6A_HUMAN	phosphodiesterase 6A	589					cytosolic calcium ion homeostasis|GMP metabolic process|platelet activation|signal transduction|visual perception	cytosol|plasma membrane	3',5'-cyclic-GMP phosphodiesterase activity|metal ion binding			ovary(1)|pancreas(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.000962)|Kidney(363;0.00147)			ATGGCCAAGGCCTCTAGGTCC	0.537		NA											10	38					0	0	0	0
FAT2	2196	broad.mit.edu	37	5	150930202	150930202	+	Silent	SNP	C	C	T			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr5:150930202C>T	uc003lue.3	-	7	4540	c.4527G>A	c.(4525-4527)GTG>GTA	p.V1509V	GM2A_uc011dcs.1_Intron	NM_001447	NP_001438	Q9NYQ8	FAT2_HUMAN	FAT tumor suppressor 2 precursor	1509	Extracellular (Potential).|Cadherin 13.				epithelial cell migration|homophilic cell adhesion	cell-cell adherens junction|integral to membrane|nucleus	calcium ion binding			ovary(4)|upper_aerodigestive_tract(1)|skin(1)	6		Medulloblastoma(196;0.0912)|all_hematologic(541;0.104)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			CCAATTTTCCCACCGTTACCA	0.522		NA											16	80					0	0	0	0
ADAMTS2	9509	broad.mit.edu	37	5	178580593	178580593	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr5:178580593C>T	uc003mjw.2	-	9	1414	c.1414G>A	c.(1414-1416)GCC>ACC	p.A472T	ADAMTS2_uc011dgm.1_Missense_Mutation_p.A472T	NM_014244	NP_055059	O95450	ATS2_HUMAN	ADAM metallopeptidase with thrombospondin type 1	472					collagen catabolic process	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			large_intestine(1)|lung(1)|ovary(1)|pancreas(1)	4	all_cancers(89;0.000456)|all_epithelial(37;0.000138)|Renal(175;0.000159)|Lung NSC(126;0.00184)|all_lung(126;0.00326)	all_cancers(40;0.00604)|all_neural(177;0.00411)|Medulloblastoma(196;0.00508)|Lung NSC(249;0.0569)|all_lung(500;0.129)|all_hematologic(541;0.211)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	GBM - Glioblastoma multiforme(465;0.0473)		CAGTCGTGGGCGAAGGGGTCA	0.657		NA											5	20					0	0	0	0
HMGN4	10473	broad.mit.edu	37	6	26545528	26545528	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr6:26545528C>T	uc003nig.2	+	2	332	c.94C>T	c.(94-96)CCA>TCA	p.P32S		NM_006353	NP_006344	O00479	HMGN4_HUMAN	high mobility group nucleosomal binding domain	32						chromatin|nucleus	DNA binding				0						GTCTGCTAAACCAGCTCCTCC	0.502		NA											15	48					0	0	0	0
GLCCI1	113263	broad.mit.edu	37	7	8110681	8110681	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr7:8110681G>T	uc003srk.2	+	6	1656	c.1097G>T	c.(1096-1098)TGT>TTT	p.C366F		NM_138426	NP_612435	Q86VQ1	GLCI1_HUMAN	glucocorticoid induced transcript 1	366											0		Ovarian(82;0.0608)		UCEC - Uterine corpus endometrioid carcinoma (126;0.206)		CATTCACCCTGTGTCTCCCCT	0.512		NA											68	167					2.48e-43	3.02e-43	1	0
NPC1L1	29881	broad.mit.edu	37	7	44560609	44560609	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr7:44560609T>C	uc003tlb.2	-	13	3118	c.3062A>G	c.(3061-3063)AAC>AGC	p.N1021S	NPC1L1_uc003tlc.2_Missense_Mutation_p.N1021S|NPC1L1_uc011kbw.1_Missense_Mutation_p.N975S|NPC1L1_uc003tla.2_Missense_Mutation_p.N24S	NM_013389	NP_037521	Q9UHC9	NPCL1_HUMAN	Niemann-Pick C1-like protein 1 isoform 1	1021	Cytoplasmic (Potential).				cholesterol biosynthetic process|intestinal cholesterol absorption|lipoprotein metabolic process	apical plasma membrane|cytoplasmic vesicle membrane|integral to membrane	hedgehog receptor activity|protein binding			ovary(3)|central_nervous_system(1)|skin(1)	5					Ezetimibe(DB00973)	ACATTTGATGTTGGGCCGGTC	0.547		NA											50	264					0	0	0	0
PION	54103	broad.mit.edu	37	7	76984548	76984548	+	Silent	SNP	C	C	A			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr7:76984548C>A	uc003ugf.2	-	16	1399	c.1320G>T	c.(1318-1320)GCG>GCT	p.A440A	PION_uc003ugg.1_Silent_p.A225A	NM_017439	NP_059135	A4D1B5	GSAP_HUMAN	pigeon homolog	440					beta-amyloid formation|regulation of proteolysis	trans-Golgi network	beta-amyloid binding			central_nervous_system(1)	1						CCAGGAACTGCGCACCTTGAC	0.473		NA											13	75					5.51e-06	6.24e-06	1	0
CYP51A1	1595	broad.mit.edu	37	7	91756928	91756928	+	Silent	SNP	C	C	T			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr7:91756928C>T	uc003ulm.3	-	4	648	c.486G>A	c.(484-486)AAG>AAA	p.K162K	CYP51A1_uc011khn.1_Silent_p.K57K|CYP51A1_uc003uln.3_Silent_p.K99K	NM_000786	NP_000777	Q16850	CP51A_HUMAN	cytochrome P450, family 51, subfamily A,	156					cholesterol biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	electron carrier activity|heme binding|sterol 14-demethylase activity				0	all_cancers(62;2.16e-09)|all_epithelial(64;3.86e-08)|Breast(17;0.00206)|all_lung(186;0.169)|all_hematologic(106;0.215)|Lung NSC(181;0.227)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)		Fluconazole(DB00196)|Itraconazole(DB01167)|Ketoconazole(DB01026)|Miconazole(DB01110)|Terconazole(DB00251)	TTAACATTTTCTTCTGCTCCA	0.303		NA											4	53					0	0	0	0
ZC3HC1	51530	broad.mit.edu	37	7	129679338	129679338	+	Silent	SNP	C	C	T			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr7:129679338C>T	uc003vpi.2	-	4	486	c.459G>A	c.(457-459)GAG>GAA	p.E153E	ZC3HC1_uc003vph.2_Silent_p.E40E|ZC3HC1_uc010lma.2_Silent_p.E40E	NM_016478	NP_057562	Q86WB0	NIPA_HUMAN	zinc finger, C3HC type 1	153	C3HC-type.				cell division|mitosis	nucleus	protein kinase binding|zinc ion binding				0	Melanoma(18;0.0435)					AACAGAACTTCTCATGGGCAG	0.388		NA											5	60					0	0	0	0
DPP6	1804	broad.mit.edu	37	7	154672633	154672633	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr7:154672633G>A	uc003wlk.2	+	21	2243	c.2114G>A	c.(2113-2115)CGC>CAC	p.R705H	DPP6_uc003wli.2_Missense_Mutation_p.R641H|DPP6_uc003wlm.2_Missense_Mutation_p.R643H|DPP6_uc011kvq.1_Missense_Mutation_p.R598H	NM_130797	NP_570629	P42658	DPP6_HUMAN	dipeptidyl-peptidase 6 isoform 1	705	Extracellular (Potential).				cell death|proteolysis	integral to membrane	dipeptidyl-peptidase activity|serine-type peptidase activity			pancreas(3)|breast(1)	4	all_neural(206;0.181)	all_hematologic(28;0.0044)|all_lung(21;0.0176)|Lung NSC(21;0.0204)	OV - Ovarian serous cystadenocarcinoma(82;0.0562)			GACAGGACGCGCGTGGCCGTG	0.552		NA											8	68					0	0	0	0
LONRF1	91694	broad.mit.edu	37	8	12594431	12594431	+	Missense_Mutation	SNP	T	T	A			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr8:12594431T>A	uc003wwd.1	-	5	1395	c.1332A>T	c.(1330-1332)AGA>AGT	p.R444S	LONRF1_uc011kxv.1_Missense_Mutation_p.R44S|LONRF1_uc010lsp.1_Missense_Mutation_p.R44S	NM_152271	NP_689484	Q17RB8	LONF1_HUMAN	LON peptidase N-terminal domain and ring finger	444					proteolysis		ATP-dependent peptidase activity|zinc ion binding			ovary(1)	1				READ - Rectum adenocarcinoma(644;0.236)		TCAGCTTATTTCTTCCATCTT	0.308		NA											9	28					0	0	0	0
ARFGEF1	10565	broad.mit.edu	37	8	68151121	68151121	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr8:68151121C>T	uc003xxo.1	-	21	3377	c.2987G>A	c.(2986-2988)AGA>AAA	p.R996K	ARFGEF1_uc003xxl.1_Missense_Mutation_p.R450K|ARFGEF1_uc003xxn.1_5'UTR	NM_006421	NP_006412	Q9Y6D6	BIG1_HUMAN	brefeldin A-inhibited guanine	996					exocytosis|regulation of ARF protein signal transduction	cytoplasm	ARF guanyl-nucleotide exchange factor activity|myosin binding			ovary(4)|upper_aerodigestive_tract(1)|large_intestine(1)|lung(1)|kidney(1)	8	Breast(64;0.214)	Lung NSC(129;0.0908)|all_lung(136;0.152)	Epithelial(68;0.0043)|OV - Ovarian serous cystadenocarcinoma(28;0.00578)|all cancers(69;0.0173)|BRCA - Breast invasive adenocarcinoma(89;0.206)			ATATGCATCTCTCTCCAGCTA	0.358		NA											16	66					0	0	0	0
MMP16	4325	broad.mit.edu	37	8	89180109	89180109	+	Silent	SNP	T	T	A	rs144277355		TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr8:89180109T>A	uc003yeb.3	-	4	780	c.498A>T	c.(496-498)ACA>ACT	p.T166T	MMP16_uc003yec.2_Silent_p.T166T	NM_005941	NP_005932	P51512	MMP16_HUMAN	matrix metalloproteinase 16 isoform 1	166	Extracellular (Potential).				collagen catabolic process|proteolysis	cell surface|integral to plasma membrane|proteinaceous extracellular matrix	calcium ion binding|enzyme activator activity|metalloendopeptidase activity|zinc ion binding			upper_aerodigestive_tract(2)|ovary(2)|central_nervous_system(1)|urinary_tract(1)|skin(1)|kidney(1)	8						CTTCTTCAAATGTCAGAGGAG	0.423		NA											9	79					0	0	0	0
RIMS2	9699	broad.mit.edu	37	8	105161040	105161040	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr8:105161040C>T	uc003yls.2	+	23	3593	c.3352C>T	c.(3352-3354)CGG>TGG	p.R1118W	RIMS2_uc003ylp.2_Intron|RIMS2_uc003ylw.2_Missense_Mutation_p.R1107W|RIMS2_uc003ylq.2_Intron|RIMS2_uc003ylr.2_Intron	NM_014677	NP_055492	Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	1157					intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			ovary(6)|lung(2)|breast(2)|skin(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	15			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			TGGTCTGTCACGGAAAAGTCG	0.463		NA								HNSCC(12;0.0054)			20	104					0	0	0	0
PSIP1	11168	broad.mit.edu	37	9	15465561	15465561	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr9:15465561C>G	uc003zlv.3	-	16	1880	c.1550G>C	c.(1549-1551)AGA>ACA	p.R517T	PSIP1_uc003zlw.3_Missense_Mutation_p.R517T|SNAPC3_uc003zlu.2_RNA	NM_033222	NP_150091	O75475	PSIP1_HUMAN	PC4 and SFRS1 interacting protein 1 isoform 2	517					initiation of viral infection|interspecies interaction between organisms|nuclear mRNA 5'-splice site recognition|provirus integration|regulation of transcription, DNA-dependent|response to heat|response to oxidative stress|transcription, DNA-dependent	cytosol|nuclear heterochromatin|nuclear periphery|nucleoplasm|nucleoplasm|transcriptionally active chromatin	activating transcription factor binding|chromatin binding|DNA secondary structure binding|RNA polymerase II transcription coactivator activity			breast(1)	1				GBM - Glioblastoma multiforme(50;2.38e-06)		TTCAGTCTCTCTCTCTTCACT	0.363		NA											24	148					0	0	0	0
CDKN2A	1029	broad.mit.edu	37	9	21971000	21971000	+	Nonsense_Mutation	SNP	C	C	A			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr9:21971000C>A	uc003zpk.2	-	2	570	c.358G>T	c.(358-360)GAG>TAG	p.E120*	MTAP_uc003zpi.1_Intron|CDKN2A_uc003zpj.2_3'UTR|CDKN2A_uc010miu.2_RNA|CDKN2A_uc003zpl.2_3'UTR	NM_000077	NP_000068	P42771	CD2A1_HUMAN	cyclin-dependent kinase inhibitor 2A isoform 1	120	ANK 4.		E -> A (in non-small cell lung carcinoma).|E -> K (in non-small cell lung carcinoma).		cell cycle arrest|cell cycle checkpoint|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of cell-matrix adhesion|negative regulation of cyclin-dependent protein kinase activity|negative regulation of NF-kappaB transcription factor activity|positive regulation of macrophage apoptosis|positive regulation of smooth muscle cell apoptosis|Ras protein signal transduction|replicative senescence	cytosol|nucleus	cyclin-dependent protein kinase inhibitor activity|NF-kappaB binding|protein binding|protein binding|protein kinase binding	p.0?(1112)|p.?(13)|p.E120*(8)|p.E120K(4)|p.E120A(1)|p.A118fs*10(1)		haematopoietic_and_lymphoid_tissue(647)|skin(419)|upper_aerodigestive_tract(414)|central_nervous_system(381)|lung(325)|pancreas(244)|oesophagus(230)|urinary_tract(225)|pleura(94)|liver(91)|soft_tissue(79)|bone(77)|ovary(76)|biliary_tract(71)|stomach(46)|breast(46)|kidney(39)|NS(28)|thyroid(24)|cervix(23)|meninges(18)|genital_tract(15)|endometrium(13)|prostate(11)|autonomic_ganglia(10)|salivary_gland(10)|large_intestine(9)|adrenal_gland(6)|eye(4)|vulva(2)|small_intestine(1)	3678		all_cancers(5;0)|Acute lymphoblastic leukemia(3;0)|all_hematologic(3;0)|all_epithelial(2;2.37e-290)|Lung NSC(2;1.26e-139)|all_lung(2;4.48e-131)|Glioma(2;3.26e-60)|all_neural(2;2.1e-52)|Renal(3;1.07e-46)|Esophageal squamous(3;3.83e-46)|Melanoma(2;2.74e-34)|Breast(3;1.14e-11)|Ovarian(3;0.000128)|Hepatocellular(5;0.00162)|Colorectal(97;0.172)		all cancers(2;0)|GBM - Glioblastoma multiforme(3;0)|Lung(2;4.07e-74)|Epithelial(2;1.08e-61)|LUSC - Lung squamous cell carcinoma(2;3.82e-48)|LUAD - Lung adenocarcinoma(2;4.56e-26)|OV - Ovarian serous cystadenocarcinoma(39;7.64e-10)|BRCA - Breast invasive adenocarcinoma(2;5.01e-09)|STAD - Stomach adenocarcinoma(4;4.63e-07)|Kidney(2;5.79e-07)|KIRC - Kidney renal clear cell carcinoma(2;7.27e-07)|COAD - Colon adenocarcinoma(8;5.15e-05)		TGGCCCAGCTCCTCAGCCAGG	0.726		17							Uveal_Melanoma_Familial|Familial_Malignant_Melanoma_and_Tumors_of_the_Nervous_System|Hereditary_Melanoma	HNSCC(2;<9.43e_08)|TSP Lung(5;3.83e-07)			21	31					1.87e-06	2.15e-06	1	0
ZNF658	26149	broad.mit.edu	37	9	40773300	40773300	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr9:40773300C>T	uc004abs.2	-	5	2127	c.1975G>A	c.(1975-1977)GAA>AAA	p.E659K	ZNF658_uc010mmm.1_Intron|ZNF658_uc010mmn.1_Missense_Mutation_p.E659K	NM_033160	NP_149350	Q5TYW1	ZN658_HUMAN	zinc finger protein 658	659	C2H2-type 11.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1				GBM - Glioblastoma multiforme(29;0.02)|Lung(182;0.0681)		TCATTACATTCATAGGGTTTC	0.418		NA											70	266					0	0	0	0
NOTCH1	4851	broad.mit.edu	37	9	139412213	139412213	+	Missense_Mutation	SNP	A	A	T			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr9:139412213A>T	uc004chz.2	-	8	1432	c.1432T>A	c.(1432-1434)TGC>AGC	p.C478S		NM_017617	NP_060087	P46531	NOTC1_HUMAN	notch1 preproprotein	478	Extracellular (Potential).|EGF-like 12; calcium-binding (Potential).				aortic valve morphogenesis|immune response|negative regulation of BMP signaling pathway|negative regulation of cell-substrate adhesion|negative regulation of myoblast differentiation|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-dependent|Notch receptor processing	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			haematopoietic_and_lymphoid_tissue(791)|upper_aerodigestive_tract(29)|lung(13)|central_nervous_system(10)|breast(9)|large_intestine(1)|skin(1)|oesophagus(1)|pancreas(1)	856	all_cancers(76;0.223)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.34e-06)|Epithelial(140;7.77e-06)		CCGGGCATGCAGATGCACTGG	0.677		NA	T|Mis|O	TRB@	T-ALL					HNSCC(8;0.001)			10	70					0	0	0	0
ARMCX2	9823	broad.mit.edu	37	X	100911937	100911937	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chrX:100911937G>A	uc004eid.2	-	3	993	c.638C>T	c.(637-639)TCG>TTG	p.S213L	ARMCX2_uc004eie.3_Missense_Mutation_p.S213L|ARMCX2_uc004eif.3_Missense_Mutation_p.S213L|ARMCX2_uc004eig.3_Missense_Mutation_p.S213L|ARMCX2_uc010nnt.2_Missense_Mutation_p.S213L	NM_177949	NP_808818	Q7L311	ARMX2_HUMAN	ALEX2 protein	213	Ala-rich.					integral to membrane	binding			ovary(6)	6						CTCGGTAGGCGATGCCACCCC	0.647		NA											8	54					0	0	0	0
XPNPEP2	7512	broad.mit.edu	37	X	128895151	128895151	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chrX:128895151G>A	uc004eut.1	+	17	1746	c.1502G>A	c.(1501-1503)CGA>CAA	p.R501Q		NM_003399	NP_003390	O43895	XPP2_HUMAN	X-prolyl aminopeptidase 2, membrane-bound	501					cellular process|proteolysis	anchored to membrane|plasma membrane	aminopeptidase activity|metal ion binding|metalloexopeptidase activity				0						CTTCCAGGGCGAATGGTGGAG	0.547		NA											6	48					0	0	0	0
ATP11C	286410	broad.mit.edu	37	X	138864754	138864754	+	Missense_Mutation	SNP	T	T	A			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chrX:138864754T>A	uc004faz.2	-	18	2012	c.1913A>T	c.(1912-1914)GAT>GTT	p.D638V	ATP11C_uc004fay.2_RNA|ATP11C_uc004fba.2_Missense_Mutation_p.D638V	NM_173694	NP_775965	Q8NB49	AT11C_HUMAN	ATPase, class VI, type 11C isoform a	638	Cytoplasmic (Potential).				ATP biosynthetic process	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(5)|large_intestine(3)	8	Acute lymphoblastic leukemia(192;0.000127)					TGTCTCAATATCATCGAAAAC	0.338		NA											15	84					0	0	0	0
MAMLD1	10046	broad.mit.edu	37	X	149639239	149639239	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chrX:149639239G>T	uc004fee.1	+	3	1470	c.1394G>T	c.(1393-1395)AGC>ATC	p.S465I	MAMLD1_uc011mxt.1_Missense_Mutation_p.S427I|MAMLD1_uc011mxu.1_Missense_Mutation_p.S440I|MAMLD1_uc011mxv.1_Missense_Mutation_p.S440I|MAMLD1_uc011mxw.1_Missense_Mutation_p.S392I	NM_005491	NP_005482	Q13495	MAMD1_HUMAN	mastermind-like domain containing 1	465					male gonad development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus					0	Acute lymphoblastic leukemia(192;6.56e-05)					AAGCTCTCTAGCCCAGGCTTG	0.517		NA											18	183					2.49e-13	2.96e-13	1	0
GAB3	139716	broad.mit.edu	37	X	153924265	153924265	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chrX:153924265C>A	uc004fmj.1	-	8	1502	c.1454G>T	c.(1453-1455)AGA>ATA	p.R485I	GAB3_uc004fmk.1_Missense_Mutation_p.R486I|GAB3_uc010nve.1_Missense_Mutation_p.R486I|GAB3_uc004fml.1_Missense_Mutation_p.R105I	NM_080612	NP_542179	Q8WWW8	GAB3_HUMAN	Gab3 protein isoform 2	485										ovary(1)	1	all_cancers(53;8.15e-17)|all_epithelial(53;1.1e-10)|all_lung(58;6.63e-07)|Lung NSC(58;2.08e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)					AATACCATTTCTTTCTGGAGA	0.373		NA											14	78					3.35e-16	4.03e-16	1	0
IL9R	3581	broad.mit.edu	37	X	155227436	155227436	+	Silent	SNP	C	C	A			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chrX:155227436C>A	uc004fnv.1	+	1	191	c.12C>A	c.(10-12)GGC>GGA	p.G4G	IL9R_uc010nvn.2_5'UTR|IL9R_uc004fnu.1_Missense_Mutation_p.Q10K	NM_002186	NP_002177	Q01113	IL9R_HUMAN	interleukin 9 receptor precursor	4					cell proliferation	extracellular space|integral to plasma membrane	interleukin-9 receptor activity				0	all_cancers(53;1.86e-17)|all_epithelial(53;2.71e-11)|all_lung(58;1.84e-07)|Lung NSC(58;5.62e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)					TGGGACTGGGCAGATGCATCT	0.542		NA											10	81					1.59e-06	1.83e-06	1	0
TCHH	7062	broad.mit.edu	37	1	152081483	152081495	+	Frame_Shift_Del	DEL	GCTCCTGGCAGCG	GCTCCTGGCAGCG	-			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr1:152081483_152081495delGCTCCTGGCAGCG	uc001ezp.2	-	2	4198_4210	c.4198_4210delCGCTGCCAGGAGC	c.(4198-4212)CGCTGCCAGGAGCGCfs	p.R1400fs	TCHH_uc009wne.1_Frame_Shift_Del_p.R1400fs	NM_007113	NP_009044	Q07283	TRHY_HUMAN	trichohyalin	1400_1404	23 X 26 AA approximate tandem repeats.				keratinization	cytoskeleton	calcium ion binding	p.R1400P(1)		ovary(3)|kidney(1)|central_nervous_system(1)	5	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TGTTGCTCGCGCTCCTGGCAGCGCAGCTGCTGT	0.577		NA											17	95	---	---	---	---	NA	NA	NA	NA
ADPGK	83440	broad.mit.edu	37	15	73044826	73044827	+	Frame_Shift_Ins	INS	-	-	T			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr15:73044826_73044827insT	uc002avg.3	-	7	1443_1444	c.1349_1350insA	c.(1348-1350)AAGfs	p.K450fs	ADPGK_uc002ave.3_Frame_Shift_Ins_p.K175fs|ADPGK_uc010ukw.1_Frame_Shift_Ins_p.K392fs|ADPGK_uc002avf.3_Frame_Shift_Ins_p.K449fs|ADPGK_uc002avi.3_Frame_Shift_Ins_p.K327fs|ADPGK_uc002avh.3_Frame_Shift_Ins_p.K211fs	NM_031284	NP_112574	Q9BRR6	ADPGK_HUMAN	ADP-dependent glucokinase	450	ADPK.				glycolysis	extracellular region	ADP-specific glucokinase activity|metal ion binding				0						CTACTACTGGCTTGTTTGGGTT	0.49		NA											7	145	---	---	---	---	NA	NA	NA	NA
SYT5	6861	broad.mit.edu	37	19	55689729	55689729	+	Frame_Shift_Del	DEL	G	G	-			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr19:55689729delG	uc002qjm.1	-	2	1147	c.87delC	c.(85-87)CCCfs	p.P29fs	SYT5_uc002qjp.2_Intron|SYT5_uc002qjn.1_Frame_Shift_Del_p.P29fs|SYT5_uc002qjo.1_Frame_Shift_Del_p.P29fs	NM_003180	NP_003171	O00445	SYT5_HUMAN	synaptotagmin V	29	Helical; (Potential).				energy reserve metabolic process|regulation of insulin secretion|synaptic transmission	cell junction|integral to membrane|recycling endosome membrane|synaptic vesicle membrane	metal ion binding|transporter activity				0			BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0452)		CCAGGGCCCAGGGGGGCACTG	0.602		NA											2	4	---	---	---	---	NA	NA	NA	NA