Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	isArtifactMode	oxoGCut
PGD	5226	broad.mit.edu	37	1	10477152	10477152	+	Nonsense_Mutation	SNP	C	C	G			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr1:10477152C>G	uc001arc.2	+	9	1043	c.953C>G	c.(952-954)TCA>TGA	p.S318*	PGD_uc001ard.2_Nonsense_Mutation_p.S238*|PGD_uc010oak.1_Nonsense_Mutation_p.S296*|PGD_uc010oal.1_Nonsense_Mutation_p.S305*	NM_002631	NP_002622	P52209	6PGD_HUMAN	phosphogluconate dehydrogenase	318					pentose-phosphate shunt, oxidative branch	cytosol	NADP binding|phosphogluconate dehydrogenase (decarboxylating) activity|protein binding			ovary(1)	1	Ovarian(185;0.203)	all_lung(284;1.31e-05)|Lung NSC(185;2.19e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.14e-07)|COAD - Colon adenocarcinoma(227;7.11e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000294)|Kidney(185;0.000728)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(132;0.00832)|READ - Rectum adenocarcinoma(331;0.0487)		GATAAGAAATCATTCCTGGAG	0.517		NA											12	57					0	0	0	0
GJA9	81025	broad.mit.edu	37	1	39340697	39340697	+	Missense_Mutation	SNP	A	A	C			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr1:39340697A>C	uc001cct.1	-	2	1355	c.1074T>G	c.(1072-1074)TTT>TTG	p.F358L	RRAGC_uc001ccr.2_5'Flank|MYCBP_uc001ccs.2_5'Flank	NM_030772	NP_110399	P57773	CXA9_HUMAN	gap junction protein, alpha 9, 59kDa	358	Cytoplasmic (Potential).				cell communication	connexon complex|integral to membrane					0	Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0393)	OV - Ovarian serous cystadenocarcinoma(33;8.23e-17)			GTTCTTTTCCAAATATTTTAT	0.343		NA											8	40					0	0	0	0
PABPC4	8761	broad.mit.edu	37	1	40034595	40034595	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr1:40034595T>C	uc010oiv.1	-	6	1653	c.755A>G	c.(754-756)AAT>AGT	p.N252S	PABPC4_uc001cdl.2_Missense_Mutation_p.N252S|PABPC4_uc001cdm.2_Missense_Mutation_p.N252S|SNORA55_uc001cdo.1_5'Flank	NM_003819	NP_003810	Q13310	PABP4_HUMAN	poly A binding protein, cytoplasmic 4 isoform 2	252	RRM 3.				blood coagulation|RNA catabolic process|RNA processing|translation	cytoplasm|ribonucleoprotein complex	nucleotide binding|poly(A) RNA binding|poly(U) RNA binding|protein binding				0	Lung NSC(20;1.55e-06)|Ovarian(52;0.00769)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;2.89e-18)|Epithelial(16;6.17e-17)|all cancers(16;1.18e-15)|LUSC - Lung squamous cell carcinoma(16;0.000261)|Lung(16;0.000457)			TTCTTTTCCATTCATCTCTTC	0.368		NA											19	85					0	0	0	0
EPHX4	253152	broad.mit.edu	37	1	92495738	92495738	+	Silent	SNP	C	C	T			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr1:92495738C>T	uc001don.2	+	1	206	c.102C>T	c.(100-102)ATC>ATT	p.I34I		NM_173567	NP_775838	Q8IUS5	EPHX4_HUMAN	abhydrolase domain containing 7	34	Helical; Signal-anchor for type II membrane protein; (Potential).					integral to membrane	hydrolase activity			central_nervous_system(1)	1						GCGCCTCCATCCACCTGCTCA	0.697		NA											4	4					0	0	0	0
NBPF10	100132406	broad.mit.edu	37	1	145368604	145368604	+	Missense_Mutation	SNP	T	T	G			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr1:145368604T>G	uc001end.3	+	86	10842	c.10807T>G	c.(10807-10809)TAC>GAC	p.Y3603D	NBPF9_uc010oye.1_Missense_Mutation_p.Y887D|NBPF10_uc001emp.3_Intron|NBPF10_uc010oyi.1_Missense_Mutation_p.Y456D|NBPF10_uc010oyk.1_Missense_Mutation_p.Y244D|NBPF10_uc010oyl.1_Missense_Mutation_p.Y244D	NM_001039703	NP_001034792	A6NDV3	A6NDV3_HUMAN	hypothetical protein LOC100132406	3528											0	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		CTTCGCCCTTTACGTGGACAA	0.443		NA											5	261					0	0	0	0
MRPL9	65005	broad.mit.edu	37	1	151735515	151735515	+	Silent	SNP	C	C	T	rs148707904		TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr1:151735515C>T	uc001eyv.2	-	2	346	c.261G>A	c.(259-261)AAG>AAA	p.K87K	MRPL9_uc009wmz.2_RNA|MRPL9_uc010pdk.1_Silent_p.K87K|MRPL9_uc009wna.1_Silent_p.K87K	NM_031420	NP_113608	Q9BYD2	RM09_HUMAN	mitochondrial ribosomal protein L9 precursor	87					translation	mitochondrial ribosome	structural constituent of ribosome			ovary(1)	1	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.14)		LUSC - Lung squamous cell carcinoma(543;0.181)			TGGGCCGATGCTTCGTGTCCT	0.647		NA											40	57					0	0	0	0
IGSF8	93185	broad.mit.edu	37	1	160061631	160061631	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr1:160061631C>A	uc001fva.2	-	6	1869	c.1824G>T	c.(1822-1824)AAG>AAT	p.K608N	IGSF8_uc001fuz.2_Missense_Mutation_p.K608N|IGSF8_uc009wtf.2_Missense_Mutation_p.K608N	NM_052868	NP_443100	Q969P0	IGSF8_HUMAN	immunoglobulin superfamily, member 8	608	Cytoplasmic (Potential).				cell proliferation|cellular component movement|nervous system development|single fertilization|skeletal muscle tissue development	integral to membrane	protein binding				0	all_cancers(52;1.11e-16)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)|LUSC - Lung squamous cell carcinoma(543;0.246)			TTCGAAGCCTCTTCATGAAGC	0.557		NA											3	56					0.00909568	0.00945098	1	0
ZNF670	93474	broad.mit.edu	37	1	247201259	247201259	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr1:247201259C>G	uc001icd.1	-	4	833	c.662G>C	c.(661-663)GGA>GCA	p.G221A	ZNF695_uc001ica.2_Intron|ZNF695_uc001icb.1_Intron	NM_033213	NP_149990	Q9BS34	ZN670_HUMAN	zinc finger protein 670	221					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1	all_cancers(71;4.01e-05)|all_epithelial(71;6.72e-06)|Ovarian(71;0.0173)|Breast(184;0.0318)|all_lung(81;0.0458)|Lung NSC(105;0.0518)	all_cancers(173;0.0266)	OV - Ovarian serous cystadenocarcinoma(106;0.00427)			GGGTTTCTCTCCAGTATGAGT	0.358		NA											7	20					0	0	0	0
DLG5	9231	broad.mit.edu	37	10	79555860	79555860	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr10:79555860C>T	uc001jzk.2	-	29	5465	c.5395G>A	c.(5395-5397)GAT>AAT	p.D1799N	DLG5_uc001jzi.2_Missense_Mutation_p.D554N|DLG5_uc001jzj.2_Missense_Mutation_p.D1214N|DLG5_uc009xru.1_RNA	NM_004747	NP_004738	Q8TDM6	DLG5_HUMAN	discs large homolog 5	1799	Guanylate kinase-like.				cell-cell adhesion|intracellular signal transduction|negative regulation of cell proliferation|regulation of apoptosis	cell junction|cytoplasm	beta-catenin binding|cytoskeletal protein binding|receptor signaling complex scaffold activity			ovary(5)|breast(3)	8	all_cancers(46;0.0316)|all_epithelial(25;0.00147)|Breast(12;0.0015)|Prostate(51;0.0146)		Epithelial(14;0.00105)|OV - Ovarian serous cystadenocarcinoma(4;0.00151)|all cancers(16;0.00446)			GTGGTCACATCGAAATGGCCG	0.517		NA											19	52					0	0	0	0
MYOF	26509	broad.mit.edu	37	10	95191243	95191243	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr10:95191243C>A	uc001kin.2	-	4	390	c.267G>T	c.(265-267)AAG>AAT	p.K89N	MYOF_uc001kio.2_Missense_Mutation_p.K89N|MYOF_uc001kip.3_Missense_Mutation_p.K89N|MYOF_uc009xuf.2_Missense_Mutation_p.K71N	NM_013451	NP_038479	Q9NZM1	MYOF_HUMAN	myoferlin isoform a	89	Cytoplasmic (Potential).				blood circulation|muscle contraction|plasma membrane repair	caveola|cytoplasmic vesicle membrane|integral to membrane|nuclear membrane	phospholipid binding|protein binding			ovary(3)|breast(1)	4						CAGTCAGGTCCTTCAGGGCTA	0.498		NA											11	27					0.000673444	0.000710858	1	0
MUC2	4583	broad.mit.edu	37	11	1098725	1098725	+	Silent	SNP	G	G	C			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr11:1098725G>C	uc001lsx.1	+	40	14208	c.14181G>C	c.(14179-14181)TCG>TCC	p.S4727S		NM_002457	NP_002448	Q02817	MUC2_HUMAN	mucin 2 precursor	4727						inner mucus layer|outer mucus layer	protein binding			lung(1)|breast(1)	2		all_cancers(49;1.08e-07)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.191)		BRCA - Breast invasive adenocarcinoma(625;0.000207)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)	Pranlukast(DB01411)	TGCCGGGCTCGAGCCTGGAGT	0.647		NA											2	5					0	0	0	0
ZNF195	7748	broad.mit.edu	37	11	3380843	3380843	+	Silent	SNP	G	G	T			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr11:3380843G>T	uc001lxt.2	-	6	1573	c.1395C>A	c.(1393-1395)CCC>CCA	p.P465P	uc001lxr.2_5'Flank|ZNF195_uc001lxv.2_Silent_p.P442P|ZNF195_uc001lxs.2_Silent_p.P393P|ZNF195_uc010qxr.1_Silent_p.P446P|ZNF195_uc009ydz.2_Silent_p.P420P|ZNF195_uc001lxu.2_Silent_p.P397P	NM_001130520	NP_001123992	O14628	ZN195_HUMAN	zinc finger protein 195 isoform 1	465					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Medulloblastoma(188;0.00106)|Breast(177;0.00328)|all_neural(188;0.00681)|Ovarian(85;0.00965)		BRCA - Breast invasive adenocarcinoma(625;0.0361)|LUSC - Lung squamous cell carcinoma(625;0.2)		CACATTGGTAGGGTTTCTCTC	0.443		NA											17	55					7.08e-05	7.71e-05	1	0
TMEM179B	374395	broad.mit.edu	37	11	62556844	62556844	+	Missense_Mutation	SNP	G	G	A	rs146539259		TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr11:62556844G>A	uc001nvd.3	+	3	395	c.365G>A	c.(364-366)CGA>CAA	p.R122Q		NM_199337	NP_955369	Q7Z7N9	T179B_HUMAN	transmembrane protein 179B	122						integral to membrane					0						TGTATCCTTCGATTTGGCACC	0.537		NA											5	29					0	0	0	0
LTBP3	4054	broad.mit.edu	37	11	65315474	65315474	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr11:65315474C>T	uc001oej.2	-	12	2032	c.1763G>A	c.(1762-1764)GGA>GAA	p.G588E	LTBP3_uc001oeg.2_5'Flank|LTBP3_uc001oeh.2_Missense_Mutation_p.G18E|LTBP3_uc010roi.1_Missense_Mutation_p.G471E|LTBP3_uc001oei.2_Missense_Mutation_p.G588E|LTBP3_uc010roj.1_Missense_Mutation_p.G289E|LTBP3_uc010rok.1_Missense_Mutation_p.G499E	NM_001130144	NP_001123616	Q9NS15	LTBP3_HUMAN	latent transforming growth factor beta binding	588	Cys-rich.|EGF-like 3.					extracellular region	calcium ion binding|growth factor binding			central_nervous_system(2)|lung(1)	3						CACGCACTCTCCGTGGCCACA	0.657		NA											13	49					0	0	0	0
GDPD4	220032	broad.mit.edu	37	11	76969569	76969569	+	Silent	SNP	G	G	A			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr11:76969569G>A	uc001oyf.2	-	10	977	c.726C>T	c.(724-726)TTC>TTT	p.F242F		NM_182833	NP_878253	Q6W3E5	GDPD4_HUMAN	glycerophosphodiester phosphodiesterase domain	242	GDPD.|Extracellular (Potential).				glycerol metabolic process|lipid metabolic process	integral to membrane	glycerophosphodiester phosphodiesterase activity|metal ion binding			skin(1)	1						CATGCATGAGGAAAGGCACAT	0.478		NA											30	109					0	0	0	0
DLG2	1740	broad.mit.edu	37	11	83770508	83770508	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr11:83770508G>A	uc001paj.2	-	6	757	c.454C>T	c.(454-456)CGG>TGG	p.R152W	DLG2_uc001pai.2_Missense_Mutation_p.R101W|DLG2_uc010rsy.1_Missense_Mutation_p.R119W|DLG2_uc010rsz.1_Missense_Mutation_p.R152W|DLG2_uc010rta.1_Missense_Mutation_p.R152W|DLG2_uc001pak.2_Missense_Mutation_p.R257W|DLG2_uc010rtb.1_Missense_Mutation_p.R119W|DLG2_uc001pal.1_Missense_Mutation_p.R152W|DLG2_uc001pam.1_Missense_Mutation_p.R191W	NM_001364	NP_001355	Q15700	DLG2_HUMAN	chapsyn-110 isoform 2	152	PDZ 1.					cell junction|postsynaptic density|postsynaptic membrane	guanylate kinase activity|protein binding|protein binding			ovary(3)|pancreas(2)|skin(1)	6		all_cancers(6;0.00791)|Acute lymphoblastic leukemia(157;4.44e-05)|all_hematologic(158;0.0036)				TCATTCACCCGCAAGATACAA	0.443		NA											3	22					0	0	0	0
EXPH5	23086	broad.mit.edu	37	11	108385200	108385200	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr11:108385200G>A	uc001pkk.2	-	6	1145	c.1034C>T	c.(1033-1035)CCA>CTA	p.P345L	EXPH5_uc010rvy.1_Missense_Mutation_p.P157L|EXPH5_uc010rvz.1_Missense_Mutation_p.P189L|EXPH5_uc010rwa.1_Missense_Mutation_p.P269L	NM_015065	NP_055880	Q8NEV8	EXPH5_HUMAN	exophilin 5 isoform a	345					intracellular protein transport		Rab GTPase binding			skin(3)|ovary(2)	5		all_cancers(61;3.99e-08)|Acute lymphoblastic leukemia(157;3.97e-05)|Melanoma(852;4.04e-05)|all_epithelial(67;0.000116)|all_hematologic(158;0.000315)|Breast(348;0.104)|all_neural(303;0.16)		Epithelial(105;8.1e-06)|BRCA - Breast invasive adenocarcinoma(274;1.22e-05)|all cancers(92;0.000129)|OV - Ovarian serous cystadenocarcinoma(223;0.11)|Colorectal(284;0.184)		AGTTGTGGCTGGAAAATGTAA	0.468		NA											4	85					0	0	0	0
DSCAML1	57453	broad.mit.edu	37	11	117335712	117335712	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr11:117335712G>A	uc001prh.1	-	17	3393	c.3391C>T	c.(3391-3393)CGG>TGG	p.R1131W		NM_020693	NP_065744	Q8TD84	DSCL1_HUMAN	Down syndrome cell adhesion molecule like 1	1071	Extracellular (Potential).|Fibronectin type-III 2.				axonogenesis|brain development|cell fate determination|dorsal/ventral pattern formation|embryonic skeletal system morphogenesis|homophilic cell adhesion	cell surface|integral to membrane|plasma membrane	protein homodimerization activity			ovary(3)|large_intestine(2)|skin(2)|upper_aerodigestive_tract(1)	8	all_hematologic(175;0.0487)	Breast(348;0.0424)|Medulloblastoma(222;0.0523)|all_hematologic(192;0.232)		BRCA - Breast invasive adenocarcinoma(274;9.12e-06)|Epithelial(105;0.00172)		GTGCCAGCCCGATTGAAGGCT	0.617		NA											18	62					0	0	0	0
ABCG4	64137	broad.mit.edu	37	11	119029006	119029006	+	Silent	SNP	C	C	G			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr11:119029006C>G	uc001pvs.2	+	10	1467	c.1131C>G	c.(1129-1131)CTC>CTG	p.L377L	ABCG4_uc009zar.2_Silent_p.L377L	NM_022169	NP_071452	Q9H172	ABCG4_HUMAN	ATP-binding cassette, subfamily G, member 4	377	Cytoplasmic (Potential).				cholesterol efflux	integral to membrane	ATP binding|ATPase activity|protein heterodimerization activity|protein homodimerization activity			ovary(2)	2	all_hematologic(175;0.0977)	Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.7e-05)		TCTGCATCCTCTTCAAGAGGA	0.572		NA											42	315					0	0	0	0
BSX	390259	broad.mit.edu	37	11	122850040	122850040	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr11:122850040C>T	uc010rzs.1	-	2	388	c.388G>A	c.(388-390)GAG>AAG	p.E130K		NM_001098169	NP_001091639	Q3C1V8	BSH_HUMAN	brain specific homeobox	130	Homeobox.										0		Breast(109;0.00249)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0361)		CGCTGGATCTCGAACCTCTTC	0.682		NA											10	98					0	0	0	0
FAM118B	79607	broad.mit.edu	37	11	126126666	126126666	+	Missense_Mutation	SNP	A	A	G			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr11:126126666A>G	uc001qdf.2	+	7	1084	c.901A>G	c.(901-903)ATC>GTC	p.I301V	FAM118B_uc009zca.2_Missense_Mutation_p.I305V|FAM118B_uc001qdg.2_Missense_Mutation_p.I301V	NM_024556	NP_078832	Q9BPY3	F118B_HUMAN	hypothetical protein LOC79607	301											0	all_hematologic(175;0.145)	Breast(109;0.00156)|Lung NSC(97;0.00948)|all_lung(97;0.0101)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.15e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0784)		GATTAAAGTCATCTCCTATGG	0.433		NA											53	168					0	0	0	0
WNK1	65125	broad.mit.edu	37	12	970337	970337	+	Silent	SNP	A	A	G			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr12:970337A>G	uc001qio.3	+	7	2286	c.1779A>G	c.(1777-1779)GTA>GTG	p.V593V	WNK1_uc001qip.3_Silent_p.V593V|WNK1_uc001qir.3_Silent_p.V40V	NM_018979	NP_061852	Q9H4A3	WNK1_HUMAN	WNK lysine deficient protein kinase 1	593					intracellular protein kinase cascade|ion transport|neuron development	cytoplasm	ATP binding|protein binding|protein kinase inhibitor activity|protein serine/threonine kinase activity			stomach(6)|breast(6)|ovary(5)|lung(4)|large_intestine(1)|central_nervous_system(1)	23	all_cancers(10;0.00611)|all_epithelial(11;0.00825)|all_lung(10;0.0331)|Ovarian(42;0.0512)|Lung NSC(10;0.0632)		Epithelial(1;1.74e-08)|all cancers(1;7.04e-08)|OV - Ovarian serous cystadenocarcinoma(31;0.000423)|BRCA - Breast invasive adenocarcinoma(9;0.0149)|Colorectal(1;0.0197)			AACAGCAGGTAGAACAATCCA	0.473		NA											25	85					0	0	0	0
PAN2	9924	broad.mit.edu	37	12	56718209	56718209	+	Silent	SNP	G	G	A			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr12:56718209G>A	uc001skx.2	-	12	2170	c.1797C>T	c.(1795-1797)GAC>GAT	p.D599D	PAN2_uc001skw.2_5'Flank|PAN2_uc001skz.2_Silent_p.D599D|PAN2_uc001sky.2_Silent_p.D599D	NM_001127460	NP_001120932	Q504Q3	PAN2_HUMAN	PAN2 polyA specific ribonuclease subunit homolog	599					nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA poly(A) tail shortening|ubiquitin-dependent protein catabolic process	cytosol|nucleus	nucleic acid binding|poly(A)-specific ribonuclease activity|ubiquitin thiolesterase activity			ovary(2)|skin(2)|large_intestine(1)|breast(1)	6						CCTCATCTGAGTCAGCCAGGA	0.498		NA											5	51					0	0	0	0
TMTC2	160335	broad.mit.edu	37	12	83359465	83359465	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr12:83359465C>G	uc001szt.2	+	6	2243	c.1811C>G	c.(1810-1812)TCT>TGT	p.S604C	TMTC2_uc001szr.1_Missense_Mutation_p.S604C|TMTC2_uc001szs.1_Missense_Mutation_p.S604C|TMTC2_uc010suk.1_Missense_Mutation_p.S359C	NM_152588	NP_689801	Q8N394	TMTC2_HUMAN	transmembrane and tetratricopeptide repeat	604						endoplasmic reticulum|integral to membrane	binding			ovary(2)	2						CACAAGAGCTCTGTTACCAGT	0.488		NA											4	71					0	0	0	0
WSCD2	9671	broad.mit.edu	37	12	108634156	108634156	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr12:108634156C>T	uc001tms.2	+	8	1924	c.1180C>T	c.(1180-1182)CGG>TGG	p.R394W	WSCD2_uc001tmt.2_Missense_Mutation_p.R394W|WSCD2_uc001tmu.2_Missense_Mutation_p.R142W	NM_014653	NP_055468	Q2TBF2	WSCD2_HUMAN	WSC domain containing 2	394						integral to membrane				ovary(1)|large_intestine(1)|breast(1)	3						GCGCAGCGGACGGACCATCTG	0.617		NA											12	147					0	0	0	0
UBE3B	89910	broad.mit.edu	37	12	109972413	109972414	+	Missense_Mutation	DNP	GG	GG	TT			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr12:109972413_109972414GG>TT	uc001top.2	+	28	3636_3637	c.3033_3034GG>TT	c.(3031-3036)CTGGGC>CTTTGC	p.G1012C	UBE3B_uc001toq.2_Missense_Mutation_p.G1012C|UBE3B_uc001tos.2_Missense_Mutation_p.G439C|UBE3B_uc001tot.2_Missense_Mutation_p.G130C|UBE3B_uc010sxp.1_3'UTR	NM_130466	NP_569733	Q7Z3V4	UBE3B_HUMAN	ubiquitin protein ligase E3B	1012	HECT.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	intracellular	ubiquitin-protein ligase activity			ovary(2)|lung(2)	4						GGGACACTCTGGGCAGCGTCCT	0.649		NA											12	41					0	0	0	0
POLE	5426	broad.mit.edu	37	12	133202825	133202825	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr12:133202825C>T	uc001uks.1	-	46	6453	c.6409G>A	c.(6409-6411)GAG>AAG	p.E2137K	POLE_uc001ukq.1_Missense_Mutation_p.E347K|POLE_uc001ukr.1_Missense_Mutation_p.E941K|POLE_uc010tbq.1_RNA	NM_006231	NP_006222	Q07864	DPOE1_HUMAN	DNA-directed DNA polymerase epsilon	2137					base-excision repair, gap-filling|DNA synthesis involved in DNA repair|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	nucleoplasm	chromatin binding|DNA binding|DNA-directed DNA polymerase activity|nucleotide binding|protein binding|zinc ion binding			ovary(3)|skin(3)|lung(1)|central_nervous_system(1)	8	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0416)		OV - Ovarian serous cystadenocarcinoma(86;5.22e-08)|Epithelial(86;4.03e-07)|all cancers(50;1.18e-05)		TCGGAGAACTCGCCGACATCC	0.602		NA						DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					4	25					0	0	0	0
SACS	26278	broad.mit.edu	37	13	23906534	23906534	+	Silent	SNP	C	C	T			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr13:23906534C>T	uc001uon.2	-	10	12070	c.11481G>A	c.(11479-11481)AAG>AAA	p.K3827K	SACS_uc001uoo.2_Silent_p.K3680K|SACS_uc001uop.1_Intron|SACS_uc001uoq.1_Intron	NM_014363	NP_055178	Q9NZJ4	SACS_HUMAN	sacsin	3827					cell death|negative regulation of inclusion body assembly|protein folding	axon|cell body fiber|dendrite|mitochondrion|nucleus	ATP binding|chaperone binding|Hsp70 protein binding|proteasome binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		all_cancers(29;1.51e-22)|all_epithelial(30;7.82e-19)|all_lung(29;4.71e-18)|Lung SC(185;0.0225)|Breast(139;0.128)		all cancers(112;0.00197)|Epithelial(112;0.00854)|OV - Ovarian serous cystadenocarcinoma(117;0.0298)|Lung(94;0.189)		CTAAAGGTAGCTTGTACAAAT	0.358		NA											14	54					0	0	0	0
STARD13	90627	broad.mit.edu	37	13	33703846	33703846	+	Missense_Mutation	SNP	A	A	T			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr13:33703846A>T	uc001uuw.2	-	5	1094	c.968T>A	c.(967-969)CTC>CAC	p.L323H	STARD13_uc001uuu.2_Missense_Mutation_p.L315H|STARD13_uc001uuv.2_Missense_Mutation_p.L205H|STARD13_uc001uux.2_Missense_Mutation_p.L288H|STARD13_uc010tec.1_RNA|STARD13_uc010abh.1_Missense_Mutation_p.L308H	NM_178006	NP_821074	Q9Y3M8	STA13_HUMAN	StAR-related lipid transfer (START) domain	323					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|lipid particle|mitochondrial membrane	GTPase activator activity|protein binding			ovary(2)|pancreas(1)|skin(1)	4	all_epithelial(80;0.155)	Lung SC(185;0.0367)		all cancers(112;1.31e-05)|Epithelial(112;0.000142)|BRCA - Breast invasive adenocarcinoma(63;0.00936)|OV - Ovarian serous cystadenocarcinoma(117;0.0533)|Lung(94;0.143)|GBM - Glioblastoma multiforme(144;0.143)		AGAGCATGGGAGCCCTTTTCT	0.597		NA											4	42					0	0	0	0
GPC5	2262	broad.mit.edu	37	13	92345977	92345977	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr13:92345977C>A	uc010tif.1	+	3	1228	c.862C>A	c.(862-864)CTT>ATT	p.L288I		NM_004466	NP_004457	P78333	GPC5_HUMAN	glypican 5 precursor	288						anchored to membrane|extracellular space|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding			ovary(2)|skin(2)|upper_aerodigestive_tract(1)	5	all_cancers(3;1.43e-07)|all_neural(89;0.0804)|Medulloblastoma(90;0.163)	Lung NSC(4;0.00454)				CATGGCGGAGCTTAATCCACA	0.532		NA											7	61					0.00307968	0.00323792	1	0
LRFN5	145581	broad.mit.edu	37	14	42356945	42356945	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr14:42356945C>T	uc001wvm.2	+	3	2315	c.1117C>T	c.(1117-1119)CAT>TAT	p.H373Y	LRFN5_uc010ana.2_Missense_Mutation_p.H373Y	NM_152447	NP_689660	Q96NI6	LRFN5_HUMAN	leucine rich repeat and fibronectin type III	373	Extracellular (Potential).|Ig-like.					integral to membrane				ovary(5)|pancreas(2)|central_nervous_system(1)	8			LUAD - Lung adenocarcinoma(50;0.0223)|Lung(238;0.0728)	GBM - Glioblastoma multiforme(112;0.00847)		AGTGGATCTTCATATAATTAA	0.403		NA								HNSCC(30;0.082)			11	54					0	0	0	0
NRXN3	9369	broad.mit.edu	37	14	79933658	79933658	+	Silent	SNP	C	C	T			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr14:79933658C>T	uc001xun.2	+	13	2729	c.2238C>T	c.(2236-2238)GCC>GCT	p.A746A	NRXN3_uc001xum.1_RNA|NRXN3_uc001xup.2_RNA|NRXN3_uc001xuq.2_Silent_p.A114A|NRXN3_uc010asw.2_Silent_p.A114A|NRXN3_uc001xur.3_Silent_p.A114A	NM_004796	NP_004787	Q9Y4C0	NRX3A_HUMAN	neurexin 3 isoform 1 precursor	1119	Extracellular (Potential).|Laminin G-like 6.				axon guidance|cell adhesion	integral to plasma membrane	metal ion binding|receptor activity			ovary(3)|upper_aerodigestive_tract(2)|pancreas(2)|central_nervous_system(1)|breast(1)|skin(1)	10		Renal(4;0.00876)		BRCA - Breast invasive adenocarcinoma(234;0.00544)|Kidney(3;0.029)|KIRC - Kidney renal clear cell carcinoma(182;0.223)		ACCGCCTTGCCGTGGGCTTCA	0.577		NA											15	50					0	0	0	0
RASGRP1	10125	broad.mit.edu	37	15	38805096	38805096	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr15:38805096C>T	uc001zke.3	-	7	915	c.737G>A	c.(736-738)CGA>CAA	p.R246Q	RASGRP1_uc010bbe.2_RNA|RASGRP1_uc010bbf.2_Missense_Mutation_p.R108Q|RASGRP1_uc010bbg.2_Missense_Mutation_p.R108Q|RASGRP1_uc001zkd.3_Missense_Mutation_p.R246Q	NM_005739	NP_005730	O95267	GRP1_HUMAN	RAS guanyl releasing protein 1 isoform a	246	Ras-GEF.				cell differentiation|platelet activation|Ras protein signal transduction|regulation of small GTPase mediated signal transduction	cytosol|endoplasmic reticulum membrane|Golgi membrane|membrane fraction|plasma membrane	calcium ion binding|guanyl-nucleotide exchange factor activity|lipid binding|protein binding			large_intestine(1)|ovary(1)	2		all_cancers(109;6.38e-17)|all_epithelial(112;5.51e-15)|Lung NSC(122;2.12e-11)|all_lung(180;5.63e-10)|Melanoma(134;0.0574)		GBM - Glioblastoma multiforme(113;1.97e-07)|BRCA - Breast invasive adenocarcinoma(123;0.00248)		AGCAATAGATCGCTCCATGGT	0.468		NA											3	18					0	0	0	0
TGM5	9333	broad.mit.edu	37	15	43552685	43552685	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr15:43552685G>A	uc001zrd.1	-	2	111	c.103C>T	c.(103-105)CGG>TGG	p.R35W	TGM5_uc001zre.1_Missense_Mutation_p.R35W	NM_201631	NP_963925	O43548	TGM5_HUMAN	transglutaminase 5 isoform 1	35					epidermis development|peptide cross-linking	cytoplasm	acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			central_nervous_system(1)	1		all_cancers(109;1.37e-14)|all_epithelial(112;1.26e-12)|Lung NSC(122;2.46e-08)|all_lung(180;2.75e-07)|Melanoma(134;0.0476)|Colorectal(260;0.216)		GBM - Glioblastoma multiforme(94;4e-07)	L-Glutamine(DB00130)	GCCTGGCCCCGGCGAACAAGC	0.572		NA											18	134					0	0	0	0
ALDH1A2	8854	broad.mit.edu	37	15	58256141	58256141	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr15:58256141C>T	uc002aex.2	-	9	1086	c.1028G>A	c.(1027-1029)CGG>CAG	p.R343Q	ALDH1A2_uc002aey.2_Missense_Mutation_p.R305Q|ALDH1A2_uc010ugv.1_Missense_Mutation_p.R322Q|ALDH1A2_uc010ugw.1_Missense_Mutation_p.R314Q|ALDH1A2_uc002aew.2_Missense_Mutation_p.R247Q	NM_003888	NP_003879	O94788	AL1A2_HUMAN	aldehyde dehydrogenase 1A2 isoform 1	343					negative regulation of cell proliferation|neural tube development|response to cytokine stimulus	nucleus	3-chloroallyl aldehyde dehydrogenase activity|retinal binding|retinal dehydrogenase activity			central_nervous_system(1)	1				GBM - Glioblastoma multiforme(80;0.152)|all cancers(107;0.18)	NADH(DB00157)|Tretinoin(DB00755)|Vitamin A(DB00162)	CCTCTTGGCCCGCTCCACGCT	0.527		NA											9	56					0	0	0	0
KIAA1024	23251	broad.mit.edu	37	15	79755583	79755583	+	Missense_Mutation	SNP	C	C	T	rs61746211	byFrequency	TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr15:79755583C>T	uc002bew.1	+	3	2548	c.2473C>T	c.(2473-2475)CGG>TGG	p.R825W	KIAA1024_uc010unk.1_Missense_Mutation_p.R825W	NM_015206	NP_056021	Q9UPX6	K1024_HUMAN	hypothetical protein LOC23251	825						integral to membrane				pancreas(2)|ovary(1)|central_nervous_system(1)	4						CGAGGTGAAGCGGGGCCAACC	0.617		NA											7	63					0	0	0	0
ARNT2	9915	broad.mit.edu	37	15	80845025	80845025	+	Silent	SNP	G	G	A			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr15:80845025G>A	uc002bfr.2	+	10	1165	c.999G>A	c.(997-999)GTG>GTA	p.V333V	ARNT2_uc010unm.1_Silent_p.V322V|ARNT2_uc002bfs.2_Silent_p.V322V	NM_014862	NP_055677	Q9HBZ2	ARNT2_HUMAN	aryl hydrocarbon receptor nuclear translocator	333	PAS 2.				central nervous system development|in utero embryonic development|response to hypoxia		aryl hydrocarbon receptor binding|DNA binding|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity|signal transducer activity			central_nervous_system(3)|ovary(1)|pancreas(1)	5			BRCA - Breast invasive adenocarcinoma(143;0.134)			GGATGTCGGTGCCCACAGAGT	0.498		NA											9	85					0	0	0	0
KIAA1199	57214	broad.mit.edu	37	15	81181835	81181835	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr15:81181835G>A	uc002bfw.1	+	9	1248	c.988G>A	c.(988-990)GAT>AAT	p.D330N	KIAA1199_uc010unn.1_Missense_Mutation_p.D330N	NM_018689	NP_061159	Q8WUJ3	K1199_HUMAN	KIAA1199 precursor	330										upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3						GGAGTGGTTCGATCATGATAA	0.473		NA											5	57					0	0	0	0
NUP93	9688	broad.mit.edu	37	16	56875619	56875619	+	Silent	SNP	C	C	A			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr16:56875619C>A	uc002eka.2	+	21	2344	c.2223C>A	c.(2221-2223)ATC>ATA	p.I741I	NUP93_uc002ekb.2_Silent_p.I618I|NUP93_uc010vhi.1_Silent_p.I618I	NM_014669	NP_055484	Q8N1F7	NUP93_HUMAN	nucleoporin 93kDa	741					carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear pore	protein binding			ovary(1)|lung(1)	2						CTATGTAGATCAGGCACAACC	0.522		NA											16	113					4.15e-12	4.66e-12	1	0
DOK4	55715	broad.mit.edu	37	16	57509069	57509069	+	Missense_Mutation	SNP	C	C	T	rs111834942	byFrequency	TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr16:57509069C>T	uc010cdb.2	-	4	650	c.352G>A	c.(352-354)GAC>AAC	p.D118N	DOK4_uc002elu.1_Missense_Mutation_p.D118N|DOK4_uc002elv.3_Missense_Mutation_p.D118N	NM_018110	NP_060580	Q8TEW6	DOK4_HUMAN	docking protein 4	118							insulin receptor binding			skin(1)	1						AGACTGATGTCGTTGAGGCGG	0.552		NA											21	90					0	0	0	0
TP53	7157	broad.mit.edu	37	17	7577539	7577539	+	Missense_Mutation	SNP	G	G	A	rs121912651		TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr17:7577539G>A	uc002gim.2	-	7	936	c.742C>T	c.(742-744)CGG>TGG	p.R248W	TP53_uc002gig.1_Missense_Mutation_p.R248W|TP53_uc002gih.2_Missense_Mutation_p.R248W|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.R116W|TP53_uc010cng.1_Missense_Mutation_p.R116W|TP53_uc002gii.1_Missense_Mutation_p.R116W|TP53_uc010cnh.1_Missense_Mutation_p.R248W|TP53_uc010cni.1_Missense_Mutation_p.R248W|TP53_uc002gij.2_Missense_Mutation_p.R248W|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.R155W|TP53_uc002gio.2_Missense_Mutation_p.R116W	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	248	|Interaction with HIPK1 (By similarity).|Interacts with the 53BP2 SH3 domain.|Interaction with AXIN1 (By similarity).		R -> W (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> P (in sporadic cancers; somatic mutation).|R -> G (in sporadic cancers; somatic mutation).|R -> L (in sporadic cancers; somatic mutation).|NR -> KW (in sporadic cancers; somatic mutation).|R -> C (in a sporadic cancer; somatic mutation).|NR -> IP (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R248Q(516)|p.R248W(443)|p.R248L(63)|p.R248P(12)|p.R248G(11)|p.R248R(10)|p.0?(7)|p.N247_R248delNR(2)|p.N247_R248>KW(2)|p.M246_P250delMNRRP(2)|p.R248fs*97(2)|p.R248_P250delRRP(1)|p.N247_R249delNRR(1)|p.N247_P250delNRRP(1)|p.R248C(1)|p.G245fs*14(1)|p.N247_R248>IP(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		ATGGGCCTCCGGTTCATGCCG	0.577	R248W(CAS1_CENTRAL_NERVOUS_SYSTEM)|R248W(COLO680N_OESOPHAGUS)|R248W(SW837_LARGE_INTESTINE)|R248W(KO52_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248W(RD_SOFT_TISSUE)|R248W(VCAP_PROSTATE)|R248W(JIMT1_BREAST)|R248W(GCT_SOFT_TISSUE)|R248W(DB_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248W(786O_KIDNEY)|R248W(COLO320_LARGE_INTESTINE)|R248W(LXF289_LUNG)|R248W(LUDLU1_LUNG)|R248W(MIAPACA2_PANCREAS)|R248W(HCC2157_BREAST)	111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			9	30					0	0	0	0
ZNF18	7566	broad.mit.edu	37	17	11895781	11895781	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr17:11895781G>T	uc002gng.1	-	4	971	c.366C>A	c.(364-366)GAC>GAA	p.D122E	ZNF18_uc002gnh.1_Missense_Mutation_p.D122E|ZNF18_uc002gni.1_Missense_Mutation_p.D122E	NM_144680	NP_653281	P17022	ZNF18_HUMAN	zinc finger protein 18	122	SCAN box.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(1)	1				Colorectal(4;3.33e-05)|COAD - Colon adenocarcinoma(4;0.000494)|READ - Rectum adenocarcinoma(10;0.233)		GTCTCTGGGGGTCCCCCTTCA	0.517		NA											8	57					5.18e-06	5.72e-06	1	0
CCDC144NL	339184	broad.mit.edu	37	17	20799105	20799105	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr17:20799105G>A	uc002gyf.2	-	1	349	c.229C>T	c.(229-231)CGC>TGC	p.R77C	uc002gyg.1_Intron|uc002gyh.1_Intron	NM_001004306	NP_001004306	Q6NUI1	C144L_HUMAN	coiled-coil domain containing 144 family,	77											0						TCTTCCAGGCGGACATCGTGC	0.642		NA											15	69					0	0	0	0
KCNJ12	3768	broad.mit.edu	37	17	21319815	21319815	+	Silent	SNP	C	C	T	rs144041366		TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr17:21319815C>T	uc002gyv.1	+	3	1866	c.1161C>T	c.(1159-1161)GAC>GAT	p.D387D		NM_021012	NP_066292	Q14500	IRK12_HUMAN	potassium inwardly-rectifying channel, subfamily	387	Cytoplasmic (By similarity).				blood circulation|muscle contraction|regulation of heart contraction|synaptic transmission	integral to membrane	inward rectifier potassium channel activity|ion channel inhibitor activity|potassium channel regulator activity			ovary(3)|skin(1)	4				Colorectal(15;0.0183)|COAD - Colon adenocarcinoma(3;0.0732)	Dofetilide(DB00204)	TGAGCCGTGACGAGGAGGATG	0.662		NA								Prostate(3;0.18)			4	58					0	0	0	0
HNF1B	6928	broad.mit.edu	37	17	36091644	36091644	+	Silent	SNP	C	C	T			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr17:36091644C>T	uc002hok.3	-	4	1208	c.987G>A	c.(985-987)CTG>CTA	p.L329L	HNF1B_uc010wdi.1_Silent_p.L303L|HNF1B_uc010cve.1_Silent_p.L137L	NM_000458	NP_000449	P35680	HNF1B_HUMAN	hepatocyte nuclear factor 1-beta isoform 1	329					endocrine pancreas development|genitalia development|kidney development|positive regulation of transcription initiation from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|pronephric nephron tubule development|regulation of pronephros size	nucleus	DNA binding|protein homodimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(3)	3		Breast(25;0.00765)|Ovarian(249;0.15)	STAD - Stomach adenocarcinoma(1;0.0142)			CGTGGGAGAGCAGAGGGTTCA	0.587		NA							Hereditary_Prostate_Cancer				5	25					0	0	0	0
SLC38A10	124565	broad.mit.edu	37	17	79226463	79226463	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr17:79226463C>T	uc002jzz.1	-	13	1852	c.1477G>A	c.(1477-1479)GAG>AAG	p.E493K	SLC38A10_uc002jzy.1_Missense_Mutation_p.E411K|SLC38A10_uc002kab.2_Missense_Mutation_p.E493K	NM_001037984	NP_001033073	Q9HBR0	S38AA_HUMAN	solute carrier family 38, member 10 isoform a	493					amino acid transport|sodium ion transport	integral to membrane				pancreas(1)|skin(1)	2	all_neural(118;0.0804)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0272)|OV - Ovarian serous cystadenocarcinoma(97;0.117)			CGGTGGGCCTCGCCCACAGGC	0.607		NA											15	41					0	0	0	0
PDE4A	5141	broad.mit.edu	37	19	10571734	10571734	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr19:10571734G>A	uc002moj.2	+	11	1528	c.1420G>A	c.(1420-1422)GAT>AAT	p.D474N	PDE4A_uc002mok.2_Missense_Mutation_p.D448N|PDE4A_uc002mol.2_Missense_Mutation_p.D413N|PDE4A_uc002mom.2_Missense_Mutation_p.D235N|PDE4A_uc002mon.2_5'UTR|PDE4A_uc002moo.2_Missense_Mutation_p.D140N	NM_001111307	NP_001104777	P27815	PDE4A_HUMAN	phosphodiesterase 4A isoform 1	474	Catalytic.	Divalent metal cation 2.|cAMP (By similarity).|Divalent metal cation 1.			signal transduction	cytosol|membrane fraction|perinuclear region of cytoplasm|ruffle membrane|soluble fraction	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding|protein binding			ovary(1)|breast(1)|central_nervous_system(1)	3			OV - Ovarian serous cystadenocarcinoma(20;5.8e-10)|Epithelial(33;7.58e-07)|all cancers(31;3.91e-06)		Cilostazol(DB01166)|Dipyridamole(DB00975)|Dyphylline(DB00651)|Enprofylline(DB00824)|Iloprost(DB01088)|Milrinone(DB00235)|Pentoxifylline(DB00806)|Phentolamine(DB00692)|Tadalafil(DB00820)|Theophylline(DB00277)	TGCCATCCACGATGTGGATCA	0.577		NA											6	20					0	0	0	0
ZNF99	7652	broad.mit.edu	37	19	22939423	22939423	+	Nonsense_Mutation	SNP	G	G	T			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr19:22939423G>T	uc010xrh.1	-	7	2748	c.2748C>A	c.(2746-2748)TAC>TAA	p.Y916*		NM_001080409	NP_001073878			zinc finger protein 99											ovary(1)|skin(1)	2		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.102)				CTTCACATTTGTACGGTTTCT	0.378		NA											6	26					8.13e-05	8.79e-05	1	0
EXOC3L2	90332	broad.mit.edu	37	19	45719439	45719439	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr19:45719439G>A	uc002pay.1	-	9	874	c.833C>T	c.(832-834)TCG>TTG	p.S278L		NM_138568	NP_612635	Q2M3D2	EX3L2_HUMAN	exocyst complex component 3-like 2	278	Potential.									ovary(1)	1		all_neural(266;0.224)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.00883)		ATCCAGCCACGAGGCCTGGGA	0.617		NA											5	33					0	0	0	0
CA11	770	broad.mit.edu	37	19	49143424	49143424	+	Silent	SNP	C	C	G			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr19:49143424C>G	uc002pjz.1	-	4	961	c.399G>C	c.(397-399)CTG>CTC	p.L133L	SEC1_uc010xzv.1_Intron|SEC1_uc002pka.2_Intron|SEC1_uc010xzw.1_Intron|SEC1_uc010ema.2_Intron|DBP_uc002pjx.3_5'Flank|DBP_uc002pjy.2_5'Flank|DBP_uc010elz.1_5'Flank	NM_001217	NP_001208	O75493	CAH11_HUMAN	carbonic anhydrase XI precursor	133						extracellular region					0		all_epithelial(76;2.38e-06)|all_lung(116;4.89e-06)|Lung NSC(112;9.34e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.000103)|all cancers(93;0.000119)|GBM - Glioblastoma multiforme(486;0.00634)|Epithelial(262;0.016)		ACAGCAGCCGCAGTTCACTGA	0.592		NA											20	53					0	0	0	0
ZNF649	65251	broad.mit.edu	37	19	52394690	52394690	+	Silent	SNP	G	G	T			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr19:52394690G>T	uc002pxy.2	-	5	967	c.699C>A	c.(697-699)CCC>CCA	p.P233P	ZNF577_uc010ydf.1_5'Flank	NM_023074	NP_075562	Q9BS31	ZN649_HUMAN	zinc finger protein 649	233					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|central_nervous_system(1)|skin(1)	3		all_neural(266;0.0602)		GBM - Glioblastoma multiforme(134;0.00152)|OV - Ovarian serous cystadenocarcinoma(262;0.0185)		TACACCCGTGGGGTTTCTCTC	0.502		NA											13	61					0.000151284	0.000162922	1	0
ZNF665	79788	broad.mit.edu	37	19	53669070	53669070	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr19:53669070G>A	uc010eqm.1	-	4	773	c.673C>T	c.(673-675)CAG>TAG	p.Q225*		NM_024733	NP_079009	Q9H7R5	ZN665_HUMAN	zinc finger protein 665	160	C2H2-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2				GBM - Glioblastoma multiforme(134;0.0196)		TGGATGACCTGATGGATTGTT	0.403		NA											7	69					0	0	0	0
ZIM2	23619	broad.mit.edu	37	19	57286846	57286846	+	Missense_Mutation	SNP	A	A	C			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr19:57286846A>C	uc002qnr.2	-	11	1176	c.794T>G	c.(793-795)CTT>CGT	p.L265R	uc010ygp.1_Intron|uc002qnp.1_Intron|ZIM2_uc010ygq.1_Missense_Mutation_p.L61R|ZIM2_uc010ygr.1_Missense_Mutation_p.L61R|ZIM2_uc002qnq.2_Missense_Mutation_p.L265R|ZIM2_uc010etp.2_Missense_Mutation_p.L265R|ZIM2_uc010ygs.1_Missense_Mutation_p.L265R	NM_015363	NP_056178	Q9NZV7	ZIM2_HUMAN	zinc finger, imprinted 2	265					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)	3		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0314)		AGGAGTCAAAAGTTTCTCTTG	0.443		NA											12	45					0	0	0	0
ZNF154	7710	broad.mit.edu	37	19	58213789	58213789	+	Silent	SNP	G	G	C			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr19:58213789G>C	uc010euf.2	-	3	768	c.528C>G	c.(526-528)CTC>CTG	p.L176L	ZNF776_uc002qpx.2_Intron|ZNF154_uc002qpy.2_RNA	NM_001085384	NP_001078853	Q13106	ZN154_HUMAN	zinc finger protein 154	176	C2H2-type 3.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0257)		AATGGTCATTGAGACTGTAGC	0.453		NA											19	111					0	0	0	0
ZSCAN22	342945	broad.mit.edu	37	19	58850557	58850557	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr19:58850557G>C	uc002qsc.2	+	3	1488	c.1341G>C	c.(1339-1341)CAG>CAC	p.Q447H	ZSCAN22_uc010yhz.1_3'UTR	NM_181846	NP_862829	P10073	ZSC22_HUMAN	zinc finger and SCAN domain containing 22	447	C2H2-type 7.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			pancreas(1)	1		all_cancers(17;3.11e-12)|all_epithelial(17;9.43e-09)|Colorectal(82;0.000256)|Lung NSC(17;0.000607)|all_lung(17;0.0024)|all_neural(62;0.0412)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0289)		CCTTTGCACAGAGCTCCTCCC	0.557		NA											7	58					0	0	0	0
BCL11A	53335	broad.mit.edu	37	2	60688817	60688817	+	Silent	SNP	G	G	A			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr2:60688817G>A	uc002sae.1	-	4	1458	c.1230C>T	c.(1228-1230)TGC>TGT	p.C410C	BCL11A_uc002sab.2_Silent_p.C410C|BCL11A_uc002sac.2_Intron|BCL11A_uc010ypi.1_Silent_p.C79C|BCL11A_uc010ypj.1_Silent_p.C376C|BCL11A_uc002sad.1_Silent_p.C258C|BCL11A_uc002saf.1_Silent_p.C376C	NM_022893	NP_075044	Q9H165	BC11A_HUMAN	B-cell CLL/lymphoma 11A isoform 1	410	C2H2-type 3.				negative regulation of axon extension|negative regulation of collateral sprouting|negative regulation of dendrite development|positive regulation of collateral sprouting|positive regulation of neuron projection development|positive regulation of transcription from RNA polymerase II promoter|protein sumoylation|regulation of dendrite development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|cytoplasm|nucleus|nucleus	nucleic acid binding|protein heterodimerization activity|protein homodimerization activity|zinc ion binding			central_nervous_system(6)|breast(3)|ovary(2)|skin(2)	13			LUSC - Lung squamous cell carcinoma(5;9.29e-08)|Lung(5;1.34e-06)|Epithelial(17;0.0562)|all cancers(80;0.199)			ACGCGTGGTCGCACAGGTTGC	0.597		NA	T	IGH@	B-CLL								18	84					0	0	0	0
DUSP11	8446	broad.mit.edu	37	2	73993700	73993700	+	Silent	SNP	G	G	C			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr2:73993700G>C	uc002sjp.2	-	8	822	c.780C>G	c.(778-780)CCC>CCG	p.P260P		NM_003584	NP_003575	O75319	DUS11_HUMAN	dual specificity phosphatase 11	213					RNA processing	nucleus	protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity|RNA binding			skin(1)	1						CACTTGACCTGGGTACACTGG	0.373		NA											6	76					0	0	0	0
ZNF2	7549	broad.mit.edu	37	2	95846873	95846873	+	Silent	SNP	C	C	T			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr2:95846873C>T	uc002suf.2	+	5	762	c.300C>T	c.(298-300)CAC>CAT	p.H100H	ZNF2_uc002sug.2_Silent_p.H58H|ZNF2_uc010yue.1_Silent_p.H62H|ZNF2_uc010fhs.2_Silent_p.H20H	NM_021088	NP_066574	Q9BSG1	ZNF2_HUMAN	zinc finger protein 2 isoform a	100					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Ovarian(717;0.00768)		READ - Rectum adenocarcinoma(193;0.0222)		CTGAGATTCACGATGCTTCAG	0.423		NA											13	68					0	0	0	0
LONRF2	164832	broad.mit.edu	37	2	100919411	100919411	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr2:100919411C>T	uc002tal.3	-	3	1533	c.893G>A	c.(892-894)TGT>TAT	p.C298Y	LONRF2_uc010yvs.1_RNA	NM_198461	NP_940863	Q1L5Z9	LONF2_HUMAN	LON peptidase N-terminal domain and ring finger	298	TPR 5.				proteolysis		ATP-dependent peptidase activity|zinc ion binding			large_intestine(1)|skin(1)	2						CACAGAGTTACATTCAGGATT	0.403		NA											26	65					0	0	0	0
DPP10	57628	broad.mit.edu	37	2	116485494	116485494	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr2:116485494G>C	uc002tla.1	+	8	1136	c.679G>C	c.(679-681)GCT>CCT	p.A227P	DPP10_uc002tlb.1_Missense_Mutation_p.A177P|DPP10_uc002tlc.1_Missense_Mutation_p.A223P|DPP10_uc002tle.2_Missense_Mutation_p.A231P|DPP10_uc002tlf.1_Missense_Mutation_p.A220P	NM_020868	NP_065919	Q8N608	DPP10_HUMAN	dipeptidyl peptidase 10 isoform long	227	Extracellular (Potential).				proteolysis	integral to membrane|membrane fraction	serine-type peptidase activity			ovary(5)|large_intestine(2)|skin(2)|breast(1)	10						TAATGGGATTGCTGACTGGTT	0.284		NA											4	36					0	0	0	0
NCL	4691	broad.mit.edu	37	2	232323778	232323778	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr2:232323778T>C	uc002vru.2	-	7	1240	c.1099A>G	c.(1099-1101)ACT>GCT	p.T367A	SNORD20_uc002vrw.1_5'Flank	NM_005381	NP_005372	P19338	NUCL_HUMAN	nucleolin	367	RRM 1.				angiogenesis	cell cortex|nucleolus|ribonucleoprotein complex	nucleotide binding|protein C-terminus binding|RNA binding|telomeric DNA binding			ovary(2)|pancreas(1)	3		Ovarian(221;1.34e-05)|Renal(207;0.0112)|Lung NSC(271;0.0339)|all_lung(227;0.0616)|all_hematologic(139;0.0748)|Hepatocellular(293;0.137)|Acute lymphoblastic leukemia(138;0.167)		Epithelial(121;1.65e-111)|LUSC - Lung squamous cell carcinoma(224;0.0115)|Lung(119;0.014)|COAD - Colon adenocarcinoma(134;0.141)|STAD - Stomach adenocarcinoma(1183;0.18)		TTCAAACCAGTGAGTTCCAAC	0.378		NA											29	46					0	0	0	0
LRRFIP1	9208	broad.mit.edu	37	2	238671551	238671551	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr2:238671551G>A	uc002vxe.2	+	11	1487	c.1195G>A	c.(1195-1197)GAC>AAC	p.D399N	LRRFIP1_uc002vxc.2_Intron|LRRFIP1_uc010znm.1_Intron|LRRFIP1_uc002vxd.2_Missense_Mutation_p.D375N|LRRFIP1_uc002vxf.2_Missense_Mutation_p.D343N	NM_001137552	NP_001131024	Q32MZ4	LRRF1_HUMAN	leucine rich repeat (in FLII) interacting	399					negative regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|cytoskeleton|nucleus	DNA binding|double-stranded RNA binding|protein binding			breast(3)	3		Breast(86;0.00257)|Renal(207;0.00571)|Ovarian(221;0.17)|all_hematologic(139;0.182)		Epithelial(121;9.75e-23)|OV - Ovarian serous cystadenocarcinoma(60;1.01e-10)|Kidney(56;4.85e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.31e-07)|BRCA - Breast invasive adenocarcinoma(100;0.000151)|Lung(119;0.0137)|LUSC - Lung squamous cell carcinoma(224;0.0325)|COAD - Colon adenocarcinoma(134;0.228)		TGCACCAGATGACAGGACCAG	0.493		NA											8	68					0	0	0	0
PAK7	57144	broad.mit.edu	37	20	9561425	9561425	+	Silent	SNP	G	G	A			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr20:9561425G>A	uc002wnl.2	-	5	902	c.357C>T	c.(355-357)CAC>CAT	p.H119H	PAK7_uc002wnk.2_Silent_p.H119H|PAK7_uc002wnj.2_Silent_p.H119H|PAK7_uc010gby.1_Silent_p.H119H	NM_020341	NP_065074	Q9P286	PAK7_HUMAN	p21-activated kinase 7	119	Linker.						ATP binding|protein binding|protein serine/threonine kinase activity			lung(11)|skin(5)|central_nervous_system(3)|ovary(2)|large_intestine(1)|stomach(1)	23			COAD - Colon adenocarcinoma(9;0.194)			TTTCTTCCGCGTGGCCTGGAC	0.527		NA											19	141					0	0	0	0
MATN4	8785	broad.mit.edu	37	20	43932984	43932984	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr20:43932984G>A	uc002xnn.2	-	3	714	c.527C>T	c.(526-528)GCG>GTG	p.A176V	MATN4_uc002xno.2_Missense_Mutation_p.A176V|MATN4_uc002xnp.2_Missense_Mutation_p.A176V|MATN4_uc010zwr.1_Missense_Mutation_p.A124V|MATN4_uc002xnr.1_Missense_Mutation_p.A176V|RBPJL_uc002xns.2_5'Flank|RBPJL_uc002xnt.2_5'Flank	NM_003833	NP_003824	O95460	MATN4_HUMAN	matrilin 4 isoform 1 precursor	176	VWFA 1.					extracellular region	protein binding				0		Myeloproliferative disorder(115;0.0122)				GCCCACGTCCGCGCGCTGCAC	0.692		NA											7	36					0	0	0	0
CTCFL	140690	broad.mit.edu	37	20	56087700	56087700	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr20:56087700T>C	uc010gix.1	-	7	2101	c.1439A>G	c.(1438-1440)CAT>CGT	p.H480R	CTCFL_uc010giw.1_Missense_Mutation_p.H480R|CTCFL_uc002xym.2_Missense_Mutation_p.H480R|CTCFL_uc010giz.1_Missense_Mutation_p.H68R|CTCFL_uc010giy.1_Missense_Mutation_p.H150R|CTCFL_uc010gja.1_Missense_Mutation_p.H430R|CTCFL_uc010gjb.1_Missense_Mutation_p.H480R|CTCFL_uc010gjc.1_Missense_Mutation_p.H480R|CTCFL_uc010gjd.1_Missense_Mutation_p.H480R|CTCFL_uc010gje.2_Missense_Mutation_p.H480R|CTCFL_uc010gjf.2_Missense_Mutation_p.H275R|CTCFL_uc010gjg.2_Missense_Mutation_p.H212R|CTCFL_uc010gjh.1_Intron|CTCFL_uc010gji.1_Missense_Mutation_p.H275R|CTCFL_uc010gjj.1_Missense_Mutation_p.H480R	NM_080618	NP_542185	Q8NI51	CTCFL_HUMAN	CCCTC-binding factor-like protein	480	C2H2-type 8.				cell cycle|DNA methylation involved in gamete generation|histone methylation|positive regulation of transcription, DNA-dependent|regulation of gene expression by genetic imprinting|regulation of histone H3-K4 methylation|transcription, DNA-dependent	cytoplasm|nucleus	histone binding|sequence-specific DNA binding|transcription regulatory region DNA binding|zinc ion binding			ovary(2)|large_intestine(1)|skin(1)	4	Lung NSC(12;0.00132)|all_lung(29;0.00433)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(13;3.95e-12)|Epithelial(14;3.41e-08)|all cancers(14;2.09e-07)			CTCATTCTTATGAGTTTTCTG	0.458		NA											10	64					0	0	0	0
ZNF831	128611	broad.mit.edu	37	20	57766526	57766526	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr20:57766526G>A	uc002yan.2	+	1	452	c.452G>A	c.(451-453)CGC>CAC	p.R151H		NM_178457	NP_848552	Q5JPB2	ZN831_HUMAN	zinc finger protein 831	151	C2H2-type 1.					intracellular	nucleic acid binding|zinc ion binding			skin(13)|ovary(1)	14	all_lung(29;0.0085)					CACTGTGGTCGCGACTGCCTG	0.662		NA											30	105					0	0	0	0
DOPEY2	9980	broad.mit.edu	37	21	37652617	37652617	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr21:37652617G>A	uc002yvg.2	+	31	6083	c.6004G>A	c.(6004-6006)GAG>AAG	p.E2002K	DOPEY2_uc011aeb.1_Missense_Mutation_p.E1951K	NM_005128	NP_005119	Q9Y3R5	DOP2_HUMAN	pad-1-like	2002					endoplasmic reticulum organization|Golgi to endosome transport|multicellular organismal development|protein transport	Golgi membrane				ovary(1)|central_nervous_system(1)	2						TTTGACTCATGAGAAAACAAT	0.308		NA											9	30					0	0	0	0
CBS	875	broad.mit.edu	37	21	44474014	44474014	+	Silent	SNP	G	G	A			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr21:44474014G>A	uc002zcu.2	-	17	1877	c.1632C>T	c.(1630-1632)GCC>GCT	p.A544A	CBS_uc002zcs.1_Silent_p.A439A|CBS_uc002zct.2_Silent_p.A544A|CBS_uc002zcw.3_Silent_p.A544A|CBS_uc002zcv.2_Silent_p.A544A	NM_000071	NP_000062	P35520	CBS_HUMAN	cystathionine-beta-synthase	544					cysteine biosynthetic process from serine|cysteine biosynthetic process via cystathionine|homocysteine catabolic process|hydrogen sulfide biosynthetic process|L-cysteine catabolic process|L-serine catabolic process	cytosol|nucleolus	cystathionine beta-synthase activity|heme binding|protein homodimerization activity|pyridoxal phosphate binding|ubiquitin protein ligase binding				0					L-Cysteine(DB00151)|L-Serine(DB00133)|Pyridoxal Phosphate(DB00114)|Pyridoxine(DB00165)|S-Adenosylmethionine(DB00118)	GCTCCTGGGCGGCCACGAAGT	0.647		NA											6	36					0	0	0	0
GNAZ	2781	broad.mit.edu	37	22	23465286	23465286	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr22:23465286G>A	uc002zwu.1	+	3	1273	c.736G>A	c.(736-738)GAG>AAG	p.E246K	RTDR1_uc002zwt.2_Intron	NM_002073	NP_002064	P19086	GNAZ_HUMAN	guanine nucleotide binding protein, alpha z	246						endoplasmic reticulum|heterotrimeric G-protein complex|nuclear envelope	G-protein beta/gamma-subunit complex binding|GTP binding|GTPase activity|guanyl-nucleotide exchange factor activity|metabotropic serotonin receptor binding|receptor signaling protein activity			kidney(1)|skin(1)	2	all_hematologic(9;0.0197)|Acute lymphoblastic leukemia(84;0.181)			READ - Rectum adenocarcinoma(21;0.166)		TCGGATGGCAGAGAGCTTGCG	0.542		NA											12	41					0	0	0	0
ELFN2	114794	broad.mit.edu	37	22	37770765	37770765	+	Silent	SNP	G	G	A			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr22:37770765G>A	uc003asq.3	-	3	1596	c.810C>T	c.(808-810)GAC>GAT	p.D270D		NM_052906	NP_443138	Q5R3F8	LRFN6_HUMAN	leucine rich repeat containing 62	270	Extracellular (Potential).					cell surface|integral to membrane				upper_aerodigestive_tract(1)|ovary(1)	2	Melanoma(58;0.0574)					CCGAGTTCTCGTCTGGCTCCC	0.687		NA											9	40					0	0	0	0
POLDIP3	84271	broad.mit.edu	37	22	42999092	42999092	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr22:42999092G>A	uc003bcu.2	-	2	233	c.134C>T	c.(133-135)ACA>ATA	p.T45I	POLDIP3_uc011app.1_5'UTR|POLDIP3_uc003bcv.2_Missense_Mutation_p.T45I|POLDIP3_uc011apq.1_Missense_Mutation_p.T45I|POLDIP3_uc010gza.2_RNA|POLDIP3_uc011apr.1_RNA|POLDIP3_uc010gzb.1_Missense_Mutation_p.T45I	NM_032311	NP_115687	Q9BY77	PDIP3_HUMAN	DNA polymerase delta interacting protein 3	45					positive regulation of translation	cytoplasm|nuclear speck	nucleotide binding|protein binding|RNA binding				0						GGCTGTGCGTGTTGACTGGCT	0.527		NA											5	69					0	0	0	0
BRD1	23774	broad.mit.edu	37	22	50181097	50181097	+	Missense_Mutation	SNP	C	C	T	rs140147452		TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr22:50181097C>T	uc003biv.2	-	7	2892	c.2405G>A	c.(2404-2406)CGG>CAG	p.R802Q	BRD1_uc011arf.1_Missense_Mutation_p.R528Q|BRD1_uc011arg.1_Missense_Mutation_p.R851Q|BRD1_uc011arh.1_Missense_Mutation_p.R802Q|BRD1_uc003biu.3_Missense_Mutation_p.R933Q	NM_014577	NP_055392	O95696	BRD1_HUMAN	bromodomain containing protein 1	802					histone H3 acetylation	MOZ/MORF histone acetyltransferase complex	zinc ion binding			pancreas(1)	1		all_cancers(38;6.11e-10)|all_epithelial(38;8.06e-09)|all_lung(38;6.64e-05)|Lung NSC(38;0.0011)|Breast(42;0.00235)|Ovarian(80;0.0139)|Lung SC(80;0.164)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0369)|BRCA - Breast invasive adenocarcinoma(115;0.21)		GCATGTGCTCCGCGACCTTTT	0.602		NA											9	39					0	0	0	0
TYMP	1890	broad.mit.edu	37	22	50967607	50967607	+	Silent	SNP	G	G	A			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr22:50967607G>A	uc003bmb.3	-	2	495	c.375C>T	c.(373-375)GTC>GTT	p.V125V	TYMP_uc003bmc.3_Silent_p.V125V|TYMP_uc003bmd.3_Silent_p.V125V|TYMP_uc010hbd.2_Silent_p.V125V|TYMP_uc003bme.3_Silent_p.V125V|TYMP_uc003bmf.3_Silent_p.V125V|TYMP_uc011arz.1_Silent_p.V125V	NM_001113756	NP_001107228	P19971	TYPH_HUMAN	endothelial cell growth factor 1	125					angiogenesis|cell differentiation|chemotaxis|DNA replication|mitochondrial genome maintenance|pyrimidine base metabolic process|pyrimidine nucleoside catabolic process|pyrimidine nucleoside salvage|pyrimidine nucleotide metabolic process	cytosol	growth factor activity|platelet-derived growth factor receptor binding|pyrimidine-nucleoside phosphorylase activity|thymidine phosphorylase activity			ovary(1)	1		all_cancers(38;4.58e-14)|all_epithelial(38;1.12e-12)|all_lung(38;3.07e-05)|Breast(42;6.27e-05)|Lung NSC(38;0.000813)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.206)|LUAD - Lung adenocarcinoma(64;0.247)	Capecitabine(DB01101)|Docetaxel(DB01248)|Floxuridine(DB00322)|Fluorouracil(DB00544)|Sulfasalazine(DB00795)|Tamoxifen(DB00675)	GGACCAGGCTGACCTTGTCAC	0.637		NA											5	52					0	0	0	0
GRM7	2917	broad.mit.edu	37	3	6903381	6903381	+	Silent	SNP	C	C	T			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr3:6903381C>T	uc003bqm.2	+	1	580	c.306C>T	c.(304-306)GGC>GGT	p.G102G	GRM7_uc011ata.1_RNA|GRM7_uc011atb.1_RNA|GRM7_uc010hcf.2_RNA|GRM7_uc011atc.1_RNA|GRM7_uc010hcg.2_Silent_p.G102G|GRM7_uc003bql.2_Silent_p.G102G	NM_000844	NP_000835	Q14831	GRM7_HUMAN	glutamate receptor, metabotropic 7 isoform a	102	Extracellular (Potential).				negative regulation of adenylate cyclase activity|negative regulation of cAMP biosynthetic process|negative regulation of glutamate secretion|sensory perception of smell|sensory perception of sound|synaptic transmission	asymmetric synapse|axon|cell cortex|dendritic shaft|integral to plasma membrane|postsynaptic membrane|presynaptic active zone	adenylate cyclase inhibitor activity|calcium ion binding|glutamate binding|group III metabotropic glutamate receptor activity|PDZ domain binding|serine binding			ovary(4)|lung(3)	7					L-Glutamic Acid(DB00142)	TGACGCTGGGCGCGCGGATCC	0.587		NA											4	15					0	0	0	0
EXOSC7	23016	broad.mit.edu	37	3	45052755	45052755	+	Missense_Mutation	SNP	A	A	T			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr3:45052755A>T	uc003coi.2	+	8	829	c.800A>T	c.(799-801)CAT>CTT	p.H267L	EXOSC7_uc003coh.1_Missense_Mutation_p.H202L|EXOSC7_uc010his.1_Missense_Mutation_p.H186L|EXOSC7_uc003coj.2_Missense_Mutation_p.H267L	NM_015004	NP_055819	Q15024	EXOS7_HUMAN	exosome component 7	267					exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|rRNA processing	cytosol|exosome (RNase complex)|nucleolus	3'-5'-exoribonuclease activity|protein binding|RNA binding				0				BRCA - Breast invasive adenocarcinoma(193;0.00911)|KIRC - Kidney renal clear cell carcinoma(197;0.0509)|Kidney(197;0.064)		AAGGTACTGCATGCCTCCTTG	0.532		NA											3	11					0	0	0	0
LOC646498	646498	broad.mit.edu	37	3	49215451	49215451	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr3:49215451C>T	uc011bcj.1	-	3	239	c.233G>A	c.(232-234)CGG>CAG	p.R78Q		NM_001080528	NP_001073997			hypothetical LOC646498												0				BRCA - Breast invasive adenocarcinoma(193;8.04e-05)|Kidney(197;0.00221)|KIRC - Kidney renal clear cell carcinoma(197;0.00247)		CAGGTCCTTCCGCCTTCCGAT	0.627		NA											5	25					0	0	0	0
SI	6476	broad.mit.edu	37	3	164767620	164767620	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr3:164767620C>T	uc003fei.2	-	14	1618	c.1556G>A	c.(1555-1557)GGA>GAA	p.G519E		NM_001041	NP_001032	P14410	SUIS_HUMAN	sucrase-isomaltase	519	Lumenal.|Isomaltase.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			ovary(7)|upper_aerodigestive_tract(4)|skin(2)|pancreas(1)	14		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	TACATTACATCCTTTTGTTGA	0.284		NA								HNSCC(35;0.089)			8	52					0	0	0	0
LRRC31	79782	broad.mit.edu	37	3	169557902	169557902	+	Silent	SNP	C	C	G			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr3:169557902C>G	uc003fgc.1	-	9	1604	c.1527G>C	c.(1525-1527)GTG>GTC	p.V509V	LRRC31_uc010hwp.1_Silent_p.V453V	NM_024727	NP_079003	Q6UY01	LRC31_HUMAN	leucine rich repeat containing 31	509										ovary(2)|skin(1)	3	all_cancers(22;2.76e-22)|all_epithelial(15;4.73e-27)|all_lung(20;9.24e-17)|Lung NSC(18;3.85e-16)|Ovarian(172;0.000223)|Breast(254;0.197)		Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.00943)			GAAGCTTGGTCACAGCATATA	0.413		NA											13	85					0	0	0	0
CLCN2	1181	broad.mit.edu	37	3	184074822	184074822	+	Silent	SNP	C	C	T			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr3:184074822C>T	uc003foi.2	-	10	1168	c.1044G>A	c.(1042-1044)GTG>GTA	p.V348V	CLCN2_uc003foh.2_5'UTR|CLCN2_uc010hya.1_Silent_p.V348V|CLCN2_uc011brl.1_Silent_p.V348V|CLCN2_uc011brm.1_Silent_p.V304V|CLCN2_uc011brn.1_Silent_p.V348V	NM_004366	NP_004357	P51788	CLCN2_HUMAN	chloride channel 2	348	Helical; (By similarity).					chloride channel complex	voltage-gated chloride channel activity				0	all_cancers(143;6.66e-11)|Ovarian(172;0.0339)		Epithelial(37;2.22e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)		Lubiprostone(DB01046)	GCTTCCGCATCACCTGGACAA	0.522		NA											7	27					0	0	0	0
MFI2	4241	broad.mit.edu	37	3	196735818	196735818	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr3:196735818T>C	uc003fxk.3	-	12	1657	c.1544A>G	c.(1543-1545)AAT>AGT	p.N515S		NM_005929	NP_005920	P08582	TRFM_HUMAN	melanoma-associated antigen p97 isoform 1	515	Transferrin-like 2.				cellular iron ion homeostasis|iron ion transport	anchored to membrane|extracellular region|integral to plasma membrane	ferric iron binding|protein binding				0	all_cancers(143;3.95e-09)|Ovarian(172;0.0634)|Breast(254;0.0838)		Epithelial(36;4.55e-24)|all cancers(36;2.87e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.76e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00536)		GCAGCTGGCATTGAAGAACTC	0.642		NA											48	75					0	0	0	0
ZBTB49	166793	broad.mit.edu	37	4	4301683	4301683	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr4:4301683T>C	uc003ghu.2	+	2	186	c.11T>C	c.(10-12)GTT>GCT	p.V4A	ZBTB49_uc003ghv.2_5'UTR|ZBTB49_uc010icy.2_RNA|ZBTB49_uc010icz.2_5'Flank	NM_145291	NP_660334	Q6ZSB9	ZBT49_HUMAN	zinc finger protein 509	4					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|skin(1)	2						ATGGACCCTGTTGCTACCCAC	0.463		NA											11	72					0	0	0	0
UGT2A3	79799	broad.mit.edu	37	4	69795796	69795796	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr4:69795796G>T	uc003hef.2	-	6	1350	c.1319C>A	c.(1318-1320)GCT>GAT	p.A440D	UGT2A3_uc010ihp.1_RNA	NM_024743	NP_079019	Q6UWM9	UD2A3_HUMAN	UDP glucuronosyltransferase 2 family,	440	Extracellular (Potential).					integral to membrane	glucuronosyltransferase activity			ovary(1)|skin(1)	2						TAATCTCATAGCATTCTCTTT	0.383		NA											8	48					0.000157383	0.000168806	1	0
ANKRD56	345079	broad.mit.edu	37	4	77818042	77818042	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr4:77818042C>T	uc003hki.2	-	1	961	c.961G>A	c.(961-963)GAT>AAT	p.D321N		NM_001029870	NP_001025041	A6NEL2	ANR56_HUMAN	ankyrin repeat domain 56	321											0						GGGCCCTGATCACGGGCCTCG	0.672		NA											6	19					0	0	0	0
GK2	2712	broad.mit.edu	37	4	80328687	80328687	+	Missense_Mutation	SNP	A	A	G			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr4:80328687A>G	uc003hlu.2	-	1	686	c.668T>C	c.(667-669)TTT>TCT	p.F223S		NM_033214	NP_149991	Q14410	GLPK2_HUMAN	glycerol kinase 2	223					glycerol-3-phosphate metabolic process	mitochondrial outer membrane	ATP binding|glycerol kinase activity			ovary(2)|skin(2)	4						TGGAATTTCAAAAAAGTCACA	0.398		NA											16	70					0	0	0	0
PDHA2	5161	broad.mit.edu	37	4	96762253	96762253	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr4:96762253C>G	uc003htr.3	+	1	1015	c.952C>G	c.(952-954)CTC>GTC	p.L318V		NM_005390	NP_005381	P29803	ODPAT_HUMAN	pyruvate dehydrogenase E1 alpha 2 precursor	318					glycolysis	mitochondrial matrix	pyruvate dehydrogenase (acetyl-transferring) activity			central_nervous_system(1)	1		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;1.23e-06)	NADH(DB00157)	TATAATAATTCTCCAAGATAG	0.423		NA											11	42					0	0	0	0
METAP1	23173	broad.mit.edu	37	4	99982433	99982433	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr4:99982433G>C	uc003huf.3	+	11	1243	c.1126G>C	c.(1126-1128)GAC>CAC	p.D376H	METAP1_uc003hug.2_RNA|METAP1_uc010ild.2_RNA	NM_015143	NP_055958	P53582	AMPM1_HUMAN	methionyl aminopeptidase 1	376					N-terminal protein amino acid modification|peptidyl-methionine modification|proteolysis|regulation of translation	cytoplasm	aminopeptidase activity|metal ion binding|metalloexopeptidase activity|protein binding				0				OV - Ovarian serous cystadenocarcinoma(123;3.12e-07)		CCGGCGACTTGACAGTGCACG	0.488		NA											6	54					0	0	0	0
FAT4	79633	broad.mit.edu	37	4	126239489	126239489	+	Silent	SNP	G	G	A			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr4:126239489G>A	uc003ifj.3	+	1	1923	c.1923G>A	c.(1921-1923)TTG>TTA	p.L641L		NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	641	Extracellular (Potential).|Cadherin 6.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18						CTGGGAGGTTGAGTACTATTT	0.567		NA											7	25					0	0	0	0
FAT1	2195	broad.mit.edu	37	4	187630504	187630504	+	Nonsense_Mutation	SNP	C	C	A			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr4:187630504C>A	uc003izf.2	-	2	666	c.478G>T	c.(478-480)GAA>TAA	p.E160*	FAT1_uc010iso.1_Nonsense_Mutation_p.E160*	NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor	160	Extracellular (Potential).|Cadherin 2.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12						GCTGTGTTTTCAGGTAAAGAA	0.463		NA								HNSCC(5;0.00058)			24	137					7.88e-14	8.88e-14	1	0
COL4A3BP	10087	broad.mit.edu	37	5	74801835	74801835	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr5:74801835G>A	uc011csu.1	-	2	625	c.203C>T	c.(202-204)TCC>TTC	p.S68F	COL4A3BP_uc003kds.2_Missense_Mutation_p.S68F|COL4A3BP_uc003kdt.2_Missense_Mutation_p.S196F|COL4A3BP_uc003kdu.2_Missense_Mutation_p.S68F	NM_005713	NP_005704	Q9Y5P4	C43BP_HUMAN	alpha 3 type IV collagen binding protein isoform	68	PH.				ER to Golgi ceramide transport|immune response	cytosol|endoplasmic reticulum membrane|Golgi apparatus	ceramide binding|phosphatidylinositol-4-phosphate binding|protein binding|protein kinase activity			skin(1)	1		all_lung(232;0.00101)|Lung NSC(167;0.00278)|Ovarian(174;0.0129)|Prostate(461;0.174)		OV - Ovarian serous cystadenocarcinoma(47;1e-53)		AAGACAGATGGATCCTCTGCA	0.299		NA											6	67					0	0	0	0
VCAN	1462	broad.mit.edu	37	5	82834287	82834287	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr5:82834287C>T	uc003kii.3	+	8	5821	c.5465C>T	c.(5464-5466)ACC>ATC	p.T1822I	VCAN_uc003kij.3_Missense_Mutation_p.T835I|VCAN_uc010jau.2_Intron|VCAN_uc003kik.3_Intron|VCAN_uc003kil.3_Missense_Mutation_p.T486I	NM_004385	NP_004376	P13611	CSPG2_HUMAN	versican isoform 1 precursor	1822	GAG-beta.				cell adhesion|cell recognition|glial cell migration	extracellular space|proteinaceous extracellular matrix	calcium ion binding|hyaluronic acid binding|sugar binding			ovary(7)|skin(6)|lung(2)|central_nervous_system(1)	16		Lung NSC(167;0.0216)|all_lung(232;0.0251)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;2.47e-41)|Epithelial(54;2.51e-34)|all cancers(79;5.19e-29)		GAAGGGCTGACCACTCTCCCA	0.488		NA											37	59					0	0	0	0
PDGFRB	5159	broad.mit.edu	37	5	149512334	149512334	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr5:149512334G>A	uc003lro.2	-	7	1575	c.1106C>T	c.(1105-1107)ACG>ATG	p.T369M	PDGFRB_uc010jhd.2_Missense_Mutation_p.T208M|PDGFRB_uc011dcg.1_3'UTR	NM_002609	NP_002600	P09619	PGFRB_HUMAN	platelet-derived growth factor receptor beta	369	Ig-like C2-type 4.|Extracellular (Potential).				aorta morphogenesis|cardiac myofibril assembly|hemopoiesis|metanephric glomerular capillary formation|metanephric glomerular mesangial cell proliferation involved in metanephros development|peptidyl-tyrosine phosphorylation|positive regulation of calcium ion import|positive regulation of chemotaxis|positive regulation of DNA biosynthetic process|positive regulation of ERK1 and ERK2 cascade|positive regulation of MAP kinase activity|positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway|positive regulation of mitosis|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of reactive oxygen species metabolic process|positive regulation of smooth muscle cell migration|positive regulation of smooth muscle cell proliferation|protein autophosphorylation|regulation of actin cytoskeleton organization|retina vasculature development in camera-type eye|smooth muscle cell chemotaxis	apical plasma membrane|cytoplasm|integral to plasma membrane|nucleus	ATP binding|platelet activating factor receptor activity|platelet-derived growth factor beta-receptor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|vascular endothelial growth factor receptor activity			central_nervous_system(4)|lung(4)|breast(3)|stomach(2)|prostate(2)|large_intestine(1)|ovary(1)	17		all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)		Becaplermin(DB00102)|Dasatinib(DB01254)|Imatinib(DB00619)|Sorafenib(DB00398)|Sunitinib(DB01268)	CACGTTGCGCGTGGACAGGGC	0.612		NA	T	ETV6|TRIP11|HIP1|RAB5EP|H4|NIN|HCMOGT-1|PDE4DIP	MPD|AML|CMML|CML								4	20					0	0	0	0
ATP10B	23120	broad.mit.edu	37	5	159992867	159992867	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr5:159992867G>C	uc003lym.1	-	26	4826	c.3979C>G	c.(3979-3981)CTA>GTA	p.L1327V	ATP10B_uc010jit.1_Missense_Mutation_p.L577V	NM_025153	NP_079429	O94823	AT10B_HUMAN	ATPase, class V, type 10B	1327	Cytoplasmic (Potential).				ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(3)|central_nervous_system(1)|pancreas(1)	5	Renal(175;0.00196)	Medulloblastoma(196;0.0377)|all_neural(177;0.121)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			TTTGAGATTAGAGACTTCCCA	0.443		NA											16	111					0	0	0	0
RANBP17	64901	broad.mit.edu	37	5	170336684	170336684	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr5:170336684C>T	uc003mba.2	+	6	525	c.509C>T	c.(508-510)TCA>TTA	p.S170L	RANBP17_uc003max.1_RNA|RANBP17_uc003may.1_RNA|RANBP17_uc003maz.1_RNA|RANBP17_uc010jjr.1_RNA|RANBP17_uc003maw.2_Missense_Mutation_p.S170L|RANBP17_uc011dew.1_Missense_Mutation_p.S170L	NM_022897	NP_075048	Q9H2T7	RBP17_HUMAN	RAN binding protein 17	170					mRNA transport|protein import into nucleus|transmembrane transport	cytoplasm|nuclear pore	GTP binding|protein transporter activity			ovary(2)|central_nervous_system(1)	3	Renal(175;0.000159)|Lung NSC(126;0.00751)|all_lung(126;0.0123)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			TCTAGACCTTCAGCAAAACAC	0.289		NA	T	TRD@	ALL								4	32					0	0	0	0
OR2J3	442186	broad.mit.edu	37	6	29080240	29080240	+	Silent	SNP	G	G	A	rs138982330	by1000genomes	TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr6:29080240G>A	uc011dll.1	+	1	573	c.573G>A	c.(571-573)TCG>TCA	p.S191S		NM_001005216	NP_001005216	O76001	OR2J3_HUMAN	olfactory receptor, family 2, subfamily J,	191	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						TGCGATTATCGTGTGTTGATA	0.463		NA											19	49					0	0	0	0
PIM1	5292	broad.mit.edu	37	6	37140900	37140900	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr6:37140900G>A	uc003onk.2	+	5	1166	c.736G>A	c.(736-738)GAA>AAA	p.E246K	PIM1_uc011dtw.1_Silent_p.T114T	NM_002648	NP_002639	P11309	PIM1_HUMAN	non-specific serine/threonine protein kinase	337	Protein kinase.				cell cycle|cell proliferation|multicellular organismal development|negative regulation of apoptosis|negative regulation of sequence-specific DNA binding transcription factor activity|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|protein autophosphorylation	cytoplasm|nucleus|plasma membrane	ATP binding|manganese ion binding|protein binding|protein binding|protein serine/threonine kinase activity|transcription factor binding			large_intestine(1)|central_nervous_system(1)	2			OV - Ovarian serous cystadenocarcinoma(102;0.241)		Adenosine monophosphate(DB00131)	CGAGCATGACGAAGAGATCAT	0.532		NA	T	BCL6	NHL								11	57					0	0	0	0
KCNK5	8645	broad.mit.edu	37	6	39158899	39158899	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr6:39158899C>T	uc003oon.2	-	5	1631	c.1267G>A	c.(1267-1269)GTG>ATG	p.V423M		NM_003740	NP_003731	O95279	KCNK5_HUMAN	potassium channel, subfamily K, member 5	423					excretion	integral to plasma membrane	potassium channel activity|voltage-gated ion channel activity			central_nervous_system(1)|skin(1)	2						TCCGTGTTCACGAAGGTGATG	0.617		NA											19	26					0	0	0	0
MDN1	23195	broad.mit.edu	37	6	90368044	90368044	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr6:90368044C>G	uc003pnn.1	-	90	15183	c.15067G>C	c.(15067-15069)GAG>CAG	p.E5023Q		NM_014611	NP_055426	Q9NU22	MDN1_HUMAN	MDN1, midasin homolog	5023					protein complex assembly|regulation of protein complex assembly	nucleus	ATP binding|ATPase activity|unfolded protein binding			ovary(8)|skin(2)	10		all_cancers(76;1.47e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00246)		BRCA - Breast invasive adenocarcinoma(108;0.0193)		TCCAAAGCCTCTGGCACCTGC	0.552		NA											17	65					0	0	0	0
AHI1	54806	broad.mit.edu	37	6	135769486	135769486	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr6:135769486C>G	uc003qgi.2	-	12	1952	c.1568G>C	c.(1567-1569)AGA>ACA	p.R523T	AHI1_uc003qgg.2_5'UTR|AHI1_uc003qgh.2_Missense_Mutation_p.R523T|AHI1_uc003qgj.2_Missense_Mutation_p.R523T|AHI1_uc003qgk.3_RNA|AHI1_uc003qgl.3_Missense_Mutation_p.R523T	NM_001134831	NP_001128303	Q8N157	AHI1_HUMAN	Abelson helper integration site 1 isoform a	523						adherens junction|cilium|microtubule basal body				ovary(1)|kidney(1)|central_nervous_system(1)	3	Breast(56;0.239)|Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00904)|OV - Ovarian serous cystadenocarcinoma(155;0.00991)		GTAATGATTTCTTGGACATTT	0.383		NA											7	32					0	0	0	0
MAP3K4	4216	broad.mit.edu	37	6	161508788	161508788	+	Silent	SNP	T	T	C			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr6:161508788T>C	uc003qtn.2	+	10	2767	c.2625T>C	c.(2623-2625)ATT>ATC	p.I875I	MAP3K4_uc010kkc.1_Silent_p.I875I|MAP3K4_uc003qto.2_Silent_p.I875I|MAP3K4_uc011efz.1_RNA|MAP3K4_uc011ega.1_Silent_p.I328I	NM_005922	NP_005913	Q9Y6R4	M3K4_HUMAN	mitogen-activated protein kinase kinase kinase 4	875					activation of MAPKK activity|JNK cascade|positive regulation of JUN kinase activity	perinuclear region of cytoplasm	ATP binding|MAP kinase kinase kinase activity|metal ion binding|protein binding			ovary(3)|lung(3)|skin(2)|stomach(1)	9		Breast(66;0.000776)|Ovarian(120;0.0367)|Prostate(117;0.0771)		OV - Ovarian serous cystadenocarcinoma(65;1.85e-18)|BRCA - Breast invasive adenocarcinoma(81;3.04e-05)		AGAAGAGTATTATTTTGCAGT	0.413		NA											3	82					0	0	0	0
SNX8	29886	broad.mit.edu	37	7	2317747	2317747	+	Silent	SNP	C	C	T			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr7:2317747C>T	uc003slw.2	-	2	331	c.288G>A	c.(286-288)GAG>GAA	p.E96E		NM_013321	NP_037453	Q9Y5X2	SNX8_HUMAN	sorting nexin 8	96	PX.				cell communication|early endosome to Golgi transport|intracellular protein transport	early endosome membrane	phosphatidylinositol binding|protein binding			large_intestine(1)|ovary(1)	2		Ovarian(82;0.11)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0853)|OV - Ovarian serous cystadenocarcinoma(56;3.79e-14)		GGCTGGAAACCTCATACTCCA	0.582		NA											3	53					0	0	0	0
TTYH3	80727	broad.mit.edu	37	7	2687663	2687663	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr7:2687663C>T	uc003smp.2	+	5	884	c.697C>T	c.(697-699)CGC>TGC	p.R233C	TTYH3_uc010ksn.2_Intron|TTYH3_uc003smq.2_Missense_Mutation_p.R62C	NM_025250	NP_079526	Q9C0H2	TTYH3_HUMAN	tweety 3	233	Cytoplasmic (Potential).					chloride channel complex|plasma membrane	chloride channel activity				0		Ovarian(82;0.0112)		OV - Ovarian serous cystadenocarcinoma(56;2.04e-14)		TGGCCTCATCCGCAGCTCCAA	0.682		NA											8	51					0	0	0	0
ZAN	7455	broad.mit.edu	37	7	100345764	100345764	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr7:100345764C>T	uc003uwj.2	+	10	1193	c.1028C>T	c.(1027-1029)GCC>GTC	p.A343V	ZAN_uc003uwk.2_Missense_Mutation_p.A343V|ZAN_uc003uwl.2_RNA|ZAN_uc010lhh.2_RNA|ZAN_uc010lhi.2_RNA	NM_003386	NP_003377	Q9Y493	ZAN_HUMAN	zonadhesin isoform 3	343	MAM 2.|Extracellular (Potential).				binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				ovary(4)|large_intestine(3)|central_nervous_system(2)|pancreas(2)	11	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			CTCCAGTTTGCCGTGGTAGGC	0.587		NA											3	21					0	0	0	0
ZC3HC1	51530	broad.mit.edu	37	7	129663445	129663445	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr7:129663445C>T	uc003vpi.2	-	8	1166	c.1139G>A	c.(1138-1140)CGA>CAA	p.R380Q	ZC3HC1_uc003vph.2_Missense_Mutation_p.R224Q|ZC3HC1_uc010lma.2_Intron	NM_016478	NP_057562	Q86WB0	NIPA_HUMAN	zinc finger, C3HC type 1	380					cell division|mitosis	nucleus	protein kinase binding|zinc ion binding				0	Melanoma(18;0.0435)					TCCCATGCTTCGGGTCACTGG	0.617		NA											19	99					0	0	0	0
TBXAS1	6916	broad.mit.edu	37	7	139661761	139661761	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr7:139661761C>T	uc011kqv.1	+	10	1168	c.1004C>T	c.(1003-1005)TCT>TTT	p.S335F	TBXAS1_uc003vvh.2_Missense_Mutation_p.S289F|TBXAS1_uc010lne.2_Missense_Mutation_p.S221F|TBXAS1_uc011kqu.1_Missense_Mutation_p.S240F|TBXAS1_uc003vvi.2_Missense_Mutation_p.S289F|TBXAS1_uc003vvj.2_Missense_Mutation_p.S289F|TBXAS1_uc011kqw.1_Missense_Mutation_p.S269F	NM_001130966	NP_001124438	P24557	THAS_HUMAN	thromboxane A synthase 1, platelet isoform	288	Lumenal (Potential).				hormone biosynthetic process|prostaglandin biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum lumen|endoplasmic reticulum membrane|integral to membrane	electron carrier activity|heme binding|monooxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen|thromboxane-A synthase activity			ovary(2)|breast(1)	3	Melanoma(164;0.0142)					GCCCGACATTCTGCAAGTCCC	0.522		NA											9	26					0	0	0	0
UNC5D	137970	broad.mit.edu	37	8	35579850	35579850	+	Missense_Mutation	SNP	G	G	A	rs149536132		TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr8:35579850G>A	uc003xjr.1	+	9	1568	c.1240G>A	c.(1240-1242)GTC>ATC	p.V414I	UNC5D_uc003xjs.1_Missense_Mutation_p.V409I|UNC5D_uc003xju.1_5'Flank|UNC5D_uc003xjt.1_Missense_Mutation_p.V172I	NM_080872	NP_543148	Q6UXZ4	UNC5D_HUMAN	unc-5 homolog D precursor	414	Cytoplasmic (Potential).				apoptosis|axon guidance	integral to membrane	receptor activity			upper_aerodigestive_tract(2)|ovary(2)|pancreas(1)|skin(1)	6				READ - Rectum adenocarcinoma(1;1.31e-05)|Colorectal(1;0.000723)		TGGCGTGGACGTCATTGACTC	0.557		NA											25	144					0	0	0	0
RALYL	138046	broad.mit.edu	37	8	85799988	85799988	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr8:85799988G>A	uc003ycq.3	+	9	1251	c.835G>A	c.(835-837)GAT>AAT	p.D279N	RALYL_uc003ycr.3_Missense_Mutation_p.D279N|RALYL_uc003ycs.3_Missense_Mutation_p.D279N|RALYL_uc010lzy.2_Missense_Mutation_p.D268N|RALYL_uc003yct.3_Missense_Mutation_p.D292N|RALYL_uc003ycu.3_Missense_Mutation_p.D206N|RALYL_uc003ycv.3_Intron	NM_001100392	NP_001093862	Q86SE5	RALYL_HUMAN	RALY RNA binding protein-like isoform 2	279							identical protein binding|nucleotide binding|RNA binding			ovary(1)	1						GGAGGACTTCGATGAAGATGG	0.458		NA											12	72					0	0	0	0
CYP11B2	1585	broad.mit.edu	37	8	143999037	143999037	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr8:143999037C>G	uc003yxk.1	-	1	223	c.220G>C	c.(220-222)GAG>CAG	p.E74Q		NM_000498	NP_000489	P19099	C11B2_HUMAN	cytochrome P450, family 11, subfamily B,	74					aldosterone biosynthetic process|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|potassium ion homeostasis|regulation of blood volume by renal aldosterone|sodium ion homeostasis|xenobiotic metabolic process		corticosterone 18-monooxygenase activity|electron carrier activity|steroid 11-beta-monooxygenase activity				0	all_cancers(97;5.56e-11)|all_epithelial(106;2.49e-08)|Lung NSC(106;0.000228)|all_lung(105;0.000633)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)				Candesartan(DB00796)|Metyrapone(DB01011)	GGCCCCAGCTCCTGGAAGGTC	0.637		NA							Familial_Hyperaldosteronism_type_I				12	58					0	0	0	0
ABCA1	19	broad.mit.edu	37	9	107558478	107558478	+	Silent	SNP	C	C	G			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr9:107558478C>G	uc004bcl.2	-	39	5551	c.5238G>C	c.(5236-5238)GGG>GGC	p.G1746G		NM_005502	NP_005493	O95477	ABCA1_HUMAN	ATP-binding cassette, sub-family A member 1	1746	Helical; (Potential).			Missing (in Ref. 7; AAD49852).	Cdc42 protein signal transduction|cellular lipid metabolic process|cholesterol efflux|cholesterol homeostasis|cholesterol metabolic process|endosome transport|G-protein coupled receptor protein signaling pathway|high-density lipoprotein particle assembly|interleukin-1 beta secretion|intracellular cholesterol transport|lysosome organization|negative regulation of cholesterol storage|negative regulation of macrophage derived foam cell differentiation|phospholipid efflux|phospholipid homeostasis|platelet dense granule organization|positive regulation of cAMP biosynthetic process|reverse cholesterol transport	integral to plasma membrane|membrane fraction|membrane raft|phagocytic vesicle	anion transmembrane transporter activity|apolipoprotein A-I receptor activity|ATP binding|ATPase activity|cholesterol transporter activity|phospholipid transporter activity|small GTPase binding|syntaxin-13 binding			large_intestine(4)|lung(4)|ovary(4)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|skin(1)|pancreas(1)	17				OV - Ovarian serous cystadenocarcinoma(323;0.023)	Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	TGATTGACCACCTGTTGAGAC	0.512		NA											24	25					0	0	0	0
TIMP1	7076	broad.mit.edu	37	X	47442865	47442865	+	Silent	SNP	G	G	A			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chrX:47442865G>A	uc004dif.2	+	2	243	c.51G>A	c.(49-51)CTG>CTA	p.L17L	SYN1_uc004did.2_Intron|SYN1_uc004die.2_Intron|TIMP1_uc011mlr.1_5'UTR|TIMP1_uc010nht.1_5'UTR	NM_003254	NP_003245	P01033	TIMP1_HUMAN	tissue inhibitor of metalloproteinase 1	17					erythrocyte maturation|negative regulation of membrane protein ectodomain proteolysis|platelet activation|platelet degranulation|positive regulation of cell proliferation	platelet alpha granule lumen	metal ion binding|metalloendopeptidase inhibitor activity|protein binding				0						TGCTGTGGCTGATAGCCCCCA	0.652		NA											6	64					0	0	0	0
ZC3H12B	340554	broad.mit.edu	37	X	64722774	64722774	+	Silent	SNP	G	G	A			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chrX:64722774G>A	uc010nko.2	+	5	2172	c.2163G>A	c.(2161-2163)CCG>CCA	p.P721P		NM_001010888	NP_001010888	Q5HYM0	ZC12B_HUMAN	zinc finger CCCH-type containing 12B	721							endonuclease activity|nucleic acid binding|zinc ion binding			lung(1)|kidney(1)|pancreas(1)	3						GCTGGGACCCGCTGCCCTGTA	0.577		NA											14	27					0	0	0	0
CYSLTR1	10800	broad.mit.edu	37	X	77529009	77529009	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chrX:77529009G>A	uc004edb.2	-	3	635	c.235C>T	c.(235-237)CGT>TGT	p.R79C	CYSLTR1_uc010nma.2_Missense_Mutation_p.R79C|CYSLTR1_uc010nmb.2_Missense_Mutation_p.R79C	NM_006639	NP_006630	Q9Y271	CLTR1_HUMAN	cysteinyl leukotriene receptor 1	79	Extracellular (Potential).				elevation of cytosolic calcium ion concentration|respiratory gaseous exchange	integral to plasma membrane|membrane fraction	leukotriene receptor activity			ovary(1)	1					Amlexanox(DB01025)|Cinalukast(DB00587)|Montelukast(DB00471)|Nedocromil(DB00716)|Pranlukast(DB01411)|Zafirlukast(DB00549)	TAGACCACACGGAGAGGCAGT	0.423		NA											7	54					0	0	0	0
TAF7L	54457	broad.mit.edu	37	X	100538563	100538563	+	Missense_Mutation	SNP	G	G	A	rs145455495		TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chrX:100538563G>A	uc004ehb.2	-	4	424	c.412C>T	c.(412-414)CGC>TGC	p.R138C	TAF7L_uc004eha.2_Missense_Mutation_p.R52C|TAF7L_uc004ehc.1_Missense_Mutation_p.R52C	NM_024885	NP_079161	Q5H9L4	TAF7L_HUMAN	TATA box binding protein-associated factor, RNA	138					cell differentiation|multicellular organismal development|regulation of transcription, DNA-dependent|spermatogenesis|transcription initiation from RNA polymerase II promoter	cytoplasm|transcription factor TFIID complex	binding			breast(1)	1						ACTGCATGGCGCCCATCAGCT	0.398		NA											95	165					0	0	0	0
DOCK11	139818	broad.mit.edu	37	X	117699986	117699986	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chrX:117699986C>T	uc004eqp.2	+	8	775	c.712C>T	c.(712-714)CAT>TAT	p.H238Y	DOCK11_uc004eqq.2_Missense_Mutation_p.H4Y	NM_144658	NP_653259	Q5JSL3	DOC11_HUMAN	dedicator of cytokinesis 11	238	PH.				blood coagulation	cytosol	GTP binding			ovary(3)	3						AATGCGCCGTCATGCTTTTGA	0.333		NA											20	185					0	0	0	0
GRIA3	2892	broad.mit.edu	37	X	122561966	122561966	+	Silent	SNP	C	C	T			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chrX:122561966C>T	uc004etq.3	+	13	2345	c.2052C>T	c.(2050-2052)TCC>TCT	p.S684S	GRIA3_uc004etr.3_Silent_p.S684S|GRIA3_uc004ets.3_RNA	NM_007325	NP_015564	P42263	GRIA3_HUMAN	glutamate receptor, ionotrophic, AMPA 3 isoform	684	Extracellular (Potential).				glutamate signaling pathway|synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|endocytic vesicle membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity			ovary(3)|central_nervous_system(1)|pancreas(1)	5					L-Glutamic Acid(DB00142)	CCCTGGACTCCGGTTCAACAA	0.423		NA											6	82					0	0	0	0
ODZ1	10178	broad.mit.edu	37	X	124097537	124097537	+	Silent	SNP	A	A	T			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chrX:124097537A>T	uc004euj.2	-	1	130	c.66T>A	c.(64-66)GCT>GCA	p.A22A	ODZ1_uc011muj.1_Silent_p.A22A|ODZ1_uc010nqy.2_Silent_p.A22A	NM_014253	NP_055068	Q9UKZ4	TEN1_HUMAN	odz, odd Oz/ten-m homolog 1 isoform 3	22	Teneurin N-terminal.|Cytoplasmic (Potential).				immune response|negative regulation of cell proliferation|nervous system development|signal transduction	extracellular region	heparin binding			ovary(11)|breast(4)|large_intestine(2)|skin(2)|pancreas(2)|upper_aerodigestive_tract(1)|lung(1)	23						AACTGGTGTAAGCTAGATCCA	0.443		NA											32	251					0	0	0	0
HS6ST2	90161	broad.mit.edu	37	X	132091167	132091167	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chrX:132091167G>A	uc011mve.1	-	3	1032	c.616C>T	c.(616-618)CCC>TCC	p.P206S	HS6ST2_uc011mvb.1_Missense_Mutation_p.P60S|HS6ST2_uc011mvc.1_Missense_Mutation_p.P60S|HS6ST2_uc011mvd.1_Missense_Mutation_p.P206S	NM_147175	NP_671704	Q96MM7	H6ST2_HUMAN	heparan sulfate 6-O-sulfotransferase 2 isoform	206	Lumenal (Potential).					integral to membrane	sulfotransferase activity				0	Acute lymphoblastic leukemia(192;0.000127)					TTGTAGCGGGGCACGAACCTG	0.652		NA											15	43					0	0	0	0
MAGEA10	4109	broad.mit.edu	37	X	151303808	151303808	+	Silent	SNP	C	C	T	rs139926957	byFrequency	TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chrX:151303808C>T	uc004ffk.2	-	5	693	c.285G>A	c.(283-285)TCG>TCA	p.S95S	MAGEA10_uc004ffl.2_Silent_p.S95S	NM_001011543	NP_001011543	P43363	MAGAA_HUMAN	melanoma antigen family A, 10	95											0	Acute lymphoblastic leukemia(192;6.56e-05)					AAGCAACGACCGAGGGGGAGG	0.532		NA											15	264					0	0	0	0
RENBP	5973	broad.mit.edu	37	X	153207481	153207481	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chrX:153207481C>T	uc004fjo.1	-	7	861	c.691G>A	c.(691-693)GAT>AAT	p.D231N	RENBP_uc011mzh.1_Intron	NM_002910	NP_002901	P51606	RENBP_HUMAN	renin binding protein	231					mannose metabolic process|regulation of blood pressure		endopeptidase inhibitor activity|mannose-6-phosphate isomerase activity|N-acylglucosamine 2-epimerase activity			ovary(1)|pancreas(1)	2	all_cancers(53;6.72e-15)|all_epithelial(53;3.19e-09)|all_lung(58;3.39e-06)|all_hematologic(71;4.25e-06)|Lung NSC(58;4.7e-06)|Acute lymphoblastic leukemia(192;6.56e-05)				N-Acetyl-D-glucosamine(DB00141)	GCTTGTCCATCCCTCTACCGG	0.617		NA											7	107					0	0	0	0
GDI1	2664	broad.mit.edu	37	X	153670046	153670046	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chrX:153670046G>A	uc004fli.3	+	8	1238	c.896G>A	c.(895-897)CGC>CAC	p.R299H	GDI1_uc011mzo.1_3'UTR|GDI1_uc004flj.2_5'Flank|FAM50A_uc004fll.3_5'Flank	NM_001493	NP_001484	P31150	GDIA_HUMAN	GDP dissociation inhibitor 1	299					protein transport|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|midbody	GTPase activator activity|protein binding				0	all_cancers(53;5.05e-16)|all_epithelial(53;1.87e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					CAGGTTATCCGCATCATCTGT	0.572		NA											7	90					0	0	0	0
NOTCH2	4853	broad.mit.edu	37	1	120466368	120466368	+	Frame_Shift_Del	DEL	T	T	-			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr1:120466368delT	uc001eik.2	-	26	5007	c.4751delA	c.(4750-4752)CAGfs	p.Q1584fs		NM_024408	NP_077719	Q04721	NOTC2_HUMAN	notch 2 preproprotein	1584	Negative regulatory region (NRR).|Extracellular (Potential).				anti-apoptosis|bone remodeling|cell cycle arrest|cell fate determination|cell growth|hemopoiesis|induction of apoptosis|negative regulation of cell proliferation|nervous system development|Notch receptor processing|Notch signaling pathway|organ morphogenesis|positive regulation of Ras protein signal transduction|regulation of transcription, DNA-dependent|stem cell maintenance|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|ligand-regulated transcription factor activity|protein binding|receptor activity	p.Q1584*(1)		lung(8)|haematopoietic_and_lymphoid_tissue(7)|ovary(4)|central_nervous_system(2)|skin(2)|kidney(2)|breast(1)|prostate(1)	27	all_neural(166;0.153)	all_lung(203;1.96e-06)|Lung NSC(69;1.47e-05)|all_epithelial(167;0.000809)		Lung(183;0.0242)|LUSC - Lung squamous cell carcinoma(189;0.133)		GAGTTCCCCCTGGGAGTCCCG	0.542		NA	N|F|Mis		marginal zone lymphoma|DLBCL				Alagille_Syndrome				19	47	---	---	---	---	NA	NA	NA	NA
SAV1	60485	broad.mit.edu	37	14	51132173	51132173	+	Frame_Shift_Del	DEL	T	T	-			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr14:51132173delT	uc001wyg.1	-	3	420	c.259delA	c.(259-261)AGAfs	p.R87fs	SAV1_uc001wyh.1_Frame_Shift_Del_p.R87fs	NM_021818	NP_068590	Q9H4B6	SAV1_HUMAN	WW45 protein	87					hippo signaling cascade	cytoplasm|nucleus	identical protein binding			breast(1)	1	all_epithelial(31;0.000611)|Breast(41;0.0333)					CTTTCTCTTCTCATTATTTCA	0.393		NA											11	18	---	---	---	---	NA	NA	NA	NA
HNRNPL	3191	broad.mit.edu	37	19	39329085	39329086	+	Frame_Shift_Ins	INS	-	-	A			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr19:39329085_39329086insA	uc010xul.1	-	10	1519_1520	c.1508_1509insT	c.(1507-1509)CTGfs	p.L503fs	HNRNPL_uc010ege.1_Intron|HNRNPL_uc002ojj.1_Frame_Shift_Ins_p.L159fs|HNRNPL_uc002ojo.1_Frame_Shift_Ins_p.L81fs|HNRNPL_uc002ojk.2_Frame_Shift_Ins_p.L159fs|HNRNPL_uc002ojl.2_Frame_Shift_Ins_p.L159fs|HNRNPL_uc010xum.1_Frame_Shift_Ins_p.L370fs	NM_001533	NP_001524	P14866	HNRPL_HUMAN	heterogeneous nuclear ribonucleoprotein L	503					nuclear mRNA splicing, via spliceosome	cytoplasm|heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	nucleotide binding|protein binding|RNA binding|transcription regulatory region DNA binding				0	all_cancers(60;6.83e-06)|Ovarian(47;0.0454)		Lung(45;0.00342)|LUSC - Lung squamous cell carcinoma(53;0.00575)			TGAAGAAGTGCAGCACGTTGCT	0.599		NA											8	27	---	---	---	---	NA	NA	NA	NA
GPRIN3	285513	broad.mit.edu	37	4	90170269	90170270	+	In_Frame_Ins	INS	-	-	CTG			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr4:90170269_90170270insCTG	uc003hsm.1	-	2	1511_1512	c.992_993insCAG	c.(991-993)AGA>AGCAGA	p.330_331insS		NM_198281	NP_938022	Q6ZVF9	GRIN3_HUMAN	G protein-regulated inducer of neurite outgrowth	330_331										ovary(3)	3		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;5.67e-05)		TGGAGACGGATCTGCTCTCGAC	0.545		NA											12	68	---	---	---	---	NA	NA	NA	NA
ADH1B	125	broad.mit.edu	37	4	100237412	100237413	+	Frame_Shift_Del	DEL	CT	CT	-			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr4:100237412_100237413delCT	uc003hus.3	-	4	390_391	c.306_307delAG	c.(304-309)AGAGTTfs	p.R102fs	ADH1A_uc011ceg.1_Intron|ADH1B_uc003hut.3_Frame_Shift_Del_p.R62fs|ADH1B_uc011ceh.1_Splice_Site_p.M3_splice|ADH1B_uc011cei.1_Frame_Shift_Del_p.R62fs	NM_000668	NP_000659	P00325	ADH1B_HUMAN	class I alcohol dehydrogenase, beta subunit	102_103					ethanol oxidation|xenobiotic metabolic process	cytosol	alcohol dehydrogenase activity, zinc-dependent|zinc ion binding			ovary(1)|breast(1)	2				OV - Ovarian serous cystadenocarcinoma(123;1.02e-07)	Fomepizole(DB01213)|NADH(DB00157)	TTTTTACAAACTCTGCATTTTC	0.386		NA											11	57	---	---	---	---	NA	NA	NA	NA
HIST1H1B	3009	broad.mit.edu	37	6	27835120	27835130	+	Frame_Shift_Del	DEL	GCCAAAGAAAG	GCCAAAGAAAG	-			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr6:27835120_27835130delGCCAAAGAAAG	uc003njx.2	-	1	230_240	c.178_188delCTTTCTTTGGC	c.(178-189)CTTTCTTTGGCAfs	p.L60fs		NM_005322	NP_005313	P16401	H15_HUMAN	histone cluster 1, H1b	60_63	H15.				nucleosome assembly	nucleosome|nucleus	DNA binding			large_intestine(2)|lung(1)	3						CTTAAGGGCTGCCAAAGAAAGGCCATTGCGC	0.611		NA											9	146	---	---	---	---	NA	NA	NA	NA
CDC40	51362	broad.mit.edu	37	6	110501792	110501793	+	Frame_Shift_Del	DEL	TC	TC	-			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr6:110501792_110501793delTC	uc003pua.2	+	1	169_170	c.145_146delTC	c.(145-147)TCTfs	p.S49fs	WASF1_uc003ptv.1_5'Flank|WASF1_uc003ptw.1_5'Flank|WASF1_uc003ptx.1_5'Flank|WASF1_uc003pty.1_5'Flank|WASF1_uc003ptz.1_5'Flank	NM_015891	NP_056975	O60508	PRP17_HUMAN	cell division cycle 40 homolog	49					mRNA 3'-end processing|mRNA export from nucleus|termination of RNA polymerase II transcription	catalytic step 2 spliceosome|nucleoplasm					0		all_cancers(87;6.23e-06)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;0.00159)|Colorectal(196;0.0488)		Epithelial(106;0.0221)|all cancers(137;0.0314)|OV - Ovarian serous cystadenocarcinoma(136;0.034)		ATCAAAGCCGTCTCTAGCAGTG	0.554		NA											8	41	---	---	---	---	NA	NA	NA	NA