Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	isArtifactMode	oxoGCut
TNFRSF25	8718	broad.mit.edu	37	1	6524760	6524760	+	Missense_Mutation	SNP	C	C	G			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr1:6524760C>G	uc001ane.2	-	4	403	c.315G>C	c.(313-315)GAG>GAC	p.E105D	TNFRSF25_uc001ana.2_Intron|TNFRSF25_uc001anb.2_RNA|TNFRSF25_uc001anc.2_RNA|TNFRSF25_uc001and.2_5'UTR|TNFRSF25_uc009vlz.2_RNA|TNFRSF25_uc001anf.2_Missense_Mutation_p.E105D|TNFRSF25_uc001ang.2_Missense_Mutation_p.E60D|TNFRSF25_uc001anh.2_Missense_Mutation_p.E105D|TNFRSF25_uc001ani.1_Missense_Mutation_p.E105D	NM_003790	NP_003781	Q93038	TNR25_HUMAN	tumor necrosis factor receptor superfamily,	105	TNFR-Cys 2.|Extracellular (Potential).				apoptosis|induction of apoptosis by extracellular signals	cytosol|extracellular region|integral to plasma membrane	tumor necrosis factor receptor activity			central_nervous_system(2)|breast(1)	3	Ovarian(185;0.0386)|all_lung(157;0.154)	all_cancers(23;1.7e-35)|all_epithelial(116;2.78e-22)|all_lung(118;7.57e-07)|Lung NSC(185;4.26e-06)|Colorectal(325;4.47e-05)|all_hematologic(16;0.00014)|Breast(487;0.000688)|Renal(390;0.0007)|Acute lymphoblastic leukemia(12;0.00157)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0448)		Epithelial(90;4.58e-35)|GBM - Glioblastoma multiforme(13;3.06e-27)|Colorectal(212;6.01e-08)|COAD - Colon adenocarcinoma(227;1.3e-05)|Kidney(185;4.88e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000871)|BRCA - Breast invasive adenocarcinoma(365;0.00105)|STAD - Stomach adenocarcinoma(132;0.00158)|READ - Rectum adenocarcinoma(331;0.0419)		CTGAACAGTTCTCCAGCGCCA	0.607		NA											17	24					0	0	0	0
BAI2	576	broad.mit.edu	37	1	32207757	32207757	+	Silent	SNP	C	C	T			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr1:32207757C>T	uc001btn.2	-	8	1668	c.1314G>A	c.(1312-1314)GGG>GGA	p.G438G	BAI2_uc010ogo.1_Silent_p.G80G|BAI2_uc010ogp.1_Silent_p.G371G|BAI2_uc010ogq.1_Silent_p.G438G|BAI2_uc001bto.2_Silent_p.G438G|BAI2_uc001btq.1_Silent_p.G371G|BAI2_uc010ogr.1_Silent_p.G371G	NM_001703	NP_001694	O60241	BAI2_HUMAN	brain-specific angiogenesis inhibitor 2	438	TSP type-1 3.|Extracellular (Potential).				negative regulation of angiogenesis|neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			lung(5)|breast(4)|ovary(2)|central_nervous_system(1)|skin(1)	13		Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0606)|all_neural(195;0.0837)|Breast(348;0.174)		STAD - Stomach adenocarcinoma(196;0.0557)		GCTGTTGGGTCCCATTGGCAC	0.662		NA											18	30					0	0	0	0
LEPR	3953	broad.mit.edu	37	1	66070790	66070790	+	Missense_Mutation	SNP	G	G	C			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr1:66070790G>C	uc001dci.2	+	11	1675	c.1473G>C	c.(1471-1473)CAG>CAC	p.Q491H	LEPR_uc001dcg.2_Missense_Mutation_p.Q491H|LEPR_uc001dch.2_Missense_Mutation_p.Q491H|LEPR_uc009waq.2_Intron|LEPR_uc001dcj.2_Missense_Mutation_p.Q491H|LEPR_uc001dck.2_Missense_Mutation_p.Q491H	NM_002303	NP_002294	P48357	LEPR_HUMAN	leptin receptor isoform 1	491	Extracellular (Potential).				energy reserve metabolic process|multicellular organismal development	extracellular region|integral to membrane|plasma membrane	cytokine receptor activity			skin(1)	1				OV - Ovarian serous cystadenocarcinoma(397;0.00722)|KIRC - Kidney renal clear cell carcinoma(1967;0.094)		GCTATTTGCAGAGTGATGGTT	0.368		NA											25	61					0	0	0	0
UBL4B	164153	broad.mit.edu	37	1	110655410	110655410	+	Missense_Mutation	SNP	C	C	T			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr1:110655410C>T	uc001dzc.2	+	1	349	c.254C>T	c.(253-255)CCG>CTG	p.P85L		NM_203412	NP_981957	Q8N7F7	UBL4B_HUMAN	ubiquitin-like 4B	85						cytoplasm				ovary(1)	1		all_cancers(81;1.14e-05)|all_epithelial(167;3.23e-06)|all_lung(203;0.000116)|Lung NSC(277;0.000233)		Lung(183;0.0236)|all cancers(265;0.0823)|Epithelial(280;0.0917)|Colorectal(144;0.109)|LUSC - Lung squamous cell carcinoma(189;0.134)		GCCCACCAGCCGCAGACCCAG	0.577		NA											14	36					0	0	0	0
PIP5K1A	8394	broad.mit.edu	37	1	151204248	151204248	+	Missense_Mutation	SNP	C	C	G			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr1:151204248C>G	uc001exj.2	+	5	791	c.339C>G	c.(337-339)TTC>TTG	p.F113L	PIP5K1A_uc001exi.2_Missense_Mutation_p.F100L|PIP5K1A_uc010pcu.1_Missense_Mutation_p.F101L|PIP5K1A_uc001exk.2_Missense_Mutation_p.F100L|PIP5K1A_uc010pcv.1_5'Flank	NM_001135638	NP_001129110	Q99755	PI51A_HUMAN	phosphatidylinositol-4-phosphate 5-kinase, type	113	PIPK.				phospholipid biosynthetic process|signal transduction	endomembrane system|Golgi stack|lamellipodium|nuclear speck	1-phosphatidylinositol-4-phosphate 5-kinase activity|ATP binding|kinase binding			ovary(1)|central_nervous_system(1)|skin(1)	3	Lung SC(34;0.00471)|Ovarian(49;0.0147)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.181)			TGCAAGATTTCTACGTGGTTG	0.483		NA											27	54					0	0	0	0
CELF3	11189	broad.mit.edu	37	1	151688428	151688428	+	Silent	SNP	C	C	G			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr1:151688428C>G	uc001eys.1	-	1	863	c.69G>C	c.(67-69)CTG>CTC	p.L23L	CELF3_uc001eyr.2_Silent_p.L23L|CELF3_uc009wmy.2_Silent_p.L23L|CELF3_uc009wmx.1_Silent_p.L23L|CELF3_uc001eyt.2_5'UTR|CELF3_uc010pdi.1_Silent_p.L23L|C1orf230_uc001eyu.2_Intron	NM_007185	NP_009116	Q5SZQ8	CELF3_HUMAN	trinucleotide repeat containing 4	23	RRM 1.				nuclear mRNA splicing, via spliceosome|regulation of alternative nuclear mRNA splicing, via spliceosome	cytoplasm|nucleus	mRNA binding|nucleotide binding			ovary(1)|central_nervous_system(1)	2						AGATGGGCTTCAGGTCCTTCT	0.597		NA											4	28					0	0	0	0
OR6K2	81448	broad.mit.edu	37	1	158669812	158669812	+	Missense_Mutation	SNP	C	C	T			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr1:158669812C>T	uc001fsu.1	-	1	631	c.631G>A	c.(631-633)GCT>ACT	p.A211T		NM_001005279	NP_001005279	Q8NGY2	OR6K2_HUMAN	olfactory receptor, family 6, subfamily K,	211	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(1)	1	all_hematologic(112;0.0378)					AGCATCACAGCTGTAATAATC	0.502		NA											19	42					0	0	0	0
CADM3	57863	broad.mit.edu	37	1	159162470	159162470	+	Nonsense_Mutation	SNP	C	C	G			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr1:159162470C>G	uc001ftl.2	+	3	474	c.332C>G	c.(331-333)TCA>TGA	p.S111*	CADM3_uc009wsx.1_Nonsense_Mutation_p.S145*|CADM3_uc009wsy.1_Nonsense_Mutation_p.S111*|CADM3_uc001ftk.2_Nonsense_Mutation_p.S145*	NM_001127173	NP_001120645	Q8N126	CADM3_HUMAN	cell adhesion molecule 3 isoform 2	111	Ig-like V-type.|Extracellular (Potential).				adherens junction organization|cell junction assembly|heterophilic cell-cell adhesion|homophilic cell adhesion	cell-cell junction|integral to membrane	protein homodimerization activity			ovary(2)	2	all_hematologic(112;0.0429)					TACACCTGCTCAATCTTCACT	0.537		NA											26	45					0	0	0	0
HMCN1	83872	broad.mit.edu	37	1	185815164	185815164	+	Missense_Mutation	SNP	G	G	T			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr1:185815164G>T	uc001grq.1	+	2	504	c.275G>T	c.(274-276)GGC>GTC	p.G92V		NM_031935	NP_114141	Q96RW7	HMCN1_HUMAN	hemicentin 1 precursor	92	VWFA.				response to stimulus|visual perception	basement membrane	calcium ion binding			ovary(22)|skin(1)	23						ACAGAAATTGGCCCAGTGACA	0.368		NA											7	35					1.13e-05	1.21e-05	1	0
OPTC	26254	broad.mit.edu	37	1	203467831	203467831	+	Silent	SNP	C	C	T			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr1:203467831C>T	uc001gzu.1	+	4	509	c.393C>T	c.(391-393)TGC>TGT	p.C131C		NM_014359	NP_055174	Q9UBM4	OPT_HUMAN	opticin precursor	131	LRRNT.|Cys-rich.					proteinaceous extracellular matrix	extracellular matrix structural constituent|protein binding				0			BRCA - Breast invasive adenocarcinoma(75;0.109)			GCCTGGTCTGCGTGTGCCTCG	0.582		NA											3	51					0	0	0	0
IRF6	3664	broad.mit.edu	37	1	209969813	209969813	+	Missense_Mutation	SNP	G	G	A			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr1:209969813G>A	uc001hhq.1	-	4	522	c.259C>T	c.(259-261)CTC>TTC	p.L87F	IRF6_uc010psm.1_5'UTR|IRF6_uc009xct.1_Missense_Mutation_p.L87F	NM_006147	NP_006138	O14896	IRF6_HUMAN	interferon regulatory factor 6	87	IRF tryptophan pentad repeat.				cell cycle arrest|interferon-gamma-mediated signaling pathway|mammary gland epithelial cell differentiation|negative regulation of cell proliferation|positive regulation of transcription, DNA-dependent|type I interferon-mediated signaling pathway	cytoplasm|nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(2)	2				OV - Ovarian serous cystadenocarcinoma(81;0.0351)		CTCTTATTGAGAGCACAGCGC	0.527		NA								HNSCC(57;0.16)			18	35					0	0	0	0
MRPL55	128308	broad.mit.edu	37	1	228295553	228295553	+	Missense_Mutation	SNP	G	G	A			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr1:228295553G>A	uc001hry.2	-	2	788	c.44C>T	c.(43-45)ACC>ATC	p.T15I	MRPL55_uc001hrz.3_Missense_Mutation_p.T51I|MRPL55_uc009xex.2_Missense_Mutation_p.T15I|MRPL55_uc001hsa.3_Missense_Mutation_p.T15I|MRPL55_uc001hsb.3_Missense_Mutation_p.T15I|MRPL55_uc001hsc.3_Missense_Mutation_p.T15I|MRPL55_uc001hsd.3_Missense_Mutation_p.T15I|MRPL55_uc001hse.3_Missense_Mutation_p.T15I|MRPL55_uc001hsf.3_Missense_Mutation_p.T15I|MRPL55_uc001hsg.3_Missense_Mutation_p.T15I	NM_181465	NP_852130	Q7Z7F7	RM55_HUMAN	mitochondrial ribosomal protein L55 isoform a	15					translation	mitochondrial large ribosomal subunit	structural constituent of ribosome			central_nervous_system(1)	1		Prostate(94;0.0405)				GGCCTTCACGGTGCTCTGCCT	0.617		NA											9	26					0	0	0	0
LYST	1130	broad.mit.edu	37	1	235973499	235973499	+	Missense_Mutation	SNP	G	G	A			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr1:235973499G>A	uc001hxj.2	-	5	794	c.619C>T	c.(619-621)CGC>TGC	p.R207C	LYST_uc009xgb.1_RNA|LYST_uc010pxs.1_RNA|LYST_uc001hxl.1_Missense_Mutation_p.R207C	NM_000081	NP_000072	Q99698	LYST_HUMAN	lysosomal trafficking regulator	207					defense response to bacterium|defense response to protozoan|defense response to virus|endosome to lysosome transport via multivesicular body sorting pathway|leukocyte chemotaxis|mast cell secretory granule organization|melanosome organization|natural killer cell mediated cytotoxicity|protein transport	cytoplasm|microtubule cytoskeleton	protein binding			ovary(6)|breast(4)|central_nervous_system(2)	12	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.00246)|Prostate(94;0.0771)|Acute lymphoblastic leukemia(190;0.228)	OV - Ovarian serous cystadenocarcinoma(106;0.000674)			GTTGCTAAGCGGTCAAGTTTA	0.413		NA							Chediak-Higashi_syndrome				5	135					0	0	0	0
OR2T33	391195	broad.mit.edu	37	1	248436971	248436971	+	Missense_Mutation	SNP	C	C	A			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr1:248436971C>A	uc010pzi.1	-	1	146	c.146G>T	c.(145-147)TGG>TTG	p.W49L		NM_001004695	NP_001004695	Q8NG76	O2T33_HUMAN	olfactory receptor, family 2, subfamily T,	49	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(1)|ovary(1)	2	all_cancers(71;0.000124)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			CCGGTGGTCCCAGTGAATCAG	0.522		NA											18	49					1.31e-17	1.5e-17	1	0
ITIH5	80760	broad.mit.edu	37	10	7618752	7618752	+	Missense_Mutation	SNP	G	G	A			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr10:7618752G>A	uc001ijq.2	-	10	1721	c.1642C>T	c.(1642-1644)CGG>TGG	p.R548W	ITIH5_uc001ijp.2_Missense_Mutation_p.R334W|ITIH5_uc001ijr.1_Missense_Mutation_p.R548W	NM_030569	NP_085046	Q86UX2	ITIH5_HUMAN	inter-alpha trypsin inhibitor heavy chain	548					hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			ovary(2)|central_nervous_system(2)	4						TTCTGAGGCCGCACAGGCACA	0.587		NA											3	29					0	0	0	0
KIAA1217	56243	broad.mit.edu	37	10	24834871	24834871	+	Missense_Mutation	SNP	C	C	T			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr10:24834871C>T	uc001iru.3	+	21	5853	c.5450C>T	c.(5449-5451)TCT>TTT	p.S1817F	KIAA1217_uc001irs.2_Missense_Mutation_p.S1138F|KIAA1217_uc001irt.3_Missense_Mutation_p.S1183F|KIAA1217_uc010qcy.1_Missense_Mutation_p.S1248F|KIAA1217_uc010qcz.1_Missense_Mutation_p.S1223F|KIAA1217_uc001irw.2_3'UTR|KIAA1217_uc001irz.2_3'UTR|KIAA1217_uc001irx.2_3'UTR|KIAA1217_uc001iry.2_3'UTR	NM_019590	NP_062536	Q5T5P2	SKT_HUMAN	sickle tail isoform 1	1817	Ser-rich.				embryonic skeletal system development	cytoplasm				ovary(5)|skin(2)	7						TCTCTGCCCTCTTCTAGTGGT	0.512		NA											43	91					0	0	0	0
ARID5B	84159	broad.mit.edu	37	10	63759861	63759861	+	Missense_Mutation	SNP	G	G	A			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr10:63759861G>A	uc001jlt.1	+	4	540	c.514G>A	c.(514-516)GAA>AAA	p.E172K	ARID5B_uc010qil.1_Missense_Mutation_p.E172K	NM_032199	NP_115575	Q14865	ARI5B_HUMAN	AT rich interactive domain 5B (MRF1-like)	172					liver development|negative regulation of transcription, DNA-dependent|positive regulation of sequence-specific DNA binding transcription factor activity|transcription, DNA-dependent		protein binding|transcription regulatory region DNA binding			ovary(2)|upper_aerodigestive_tract(1)|kidney(1)	4	Prostate(12;0.016)|all_hematologic(501;0.215)					GGAGGACGAGGAAGAAACGAA	0.473		NA											8	22					0	0	0	0
ANKRD1	27063	broad.mit.edu	37	10	92678707	92678707	+	Missense_Mutation	SNP	G	G	A	rs145387010		TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr10:92678707G>A	uc001khe.1	-	4	616	c.368C>T	c.(367-369)ACG>ATG	p.T123M		NM_014391	NP_055206	Q15327	ANKR1_HUMAN	cardiac ankyrin repeat protein	123					cellular lipid metabolic process|defense response|signal transduction		DNA binding				0		Colorectal(252;0.0475)				CTTCAGAAACGTAGGCACATC	0.368		NA											8	35					0	0	0	0
MGEA5	10724	broad.mit.edu	37	10	103569963	103569963	+	Missense_Mutation	SNP	G	G	A			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr10:103569963G>A	uc001ktv.2	-	4	901	c.458C>T	c.(457-459)ACA>ATA	p.T153I	MGEA5_uc010qqe.1_Missense_Mutation_p.T153I|MGEA5_uc009xws.2_Missense_Mutation_p.T153I|MGEA5_uc001ktw.2_Missense_Mutation_p.T153I|MGEA5_uc009xwt.2_Intron|MGEA5_uc010qqf.1_RNA	NM_012215	NP_036347	O60502	NCOAT_HUMAN	meningioma expressed antigen 5 (hyaluronidase)	153					glycoprotein catabolic process	cytoplasm|nucleus	histone acetyltransferase activity|hyalurononglucosaminidase activity			ovary(2)|skin(1)	3		Colorectal(252;0.207)		Epithelial(162;4.67e-09)|all cancers(201;2.54e-07)		ACGTTTCAATGTGGATACTTC	0.373		NA											5	63					0	0	0	0
TRIM8	81603	broad.mit.edu	37	10	104416918	104416918	+	Missense_Mutation	SNP	C	C	T			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr10:104416918C>T	uc001kvz.2	+	6	1586	c.1463C>T	c.(1462-1464)CCC>CTC	p.P488L		NM_030912	NP_112174	Q9BZR9	TRIM8_HUMAN	tripartite motif-containing 8	488						cytoplasm|PML body	ligase activity|protein homodimerization activity|zinc ion binding			ovary(1)	1		Colorectal(252;0.122)		Epithelial(162;3.93e-09)|all cancers(201;1.02e-07)|BRCA - Breast invasive adenocarcinoma(275;0.215)		CAGCCCTACCCCCGCTCCGGC	0.657		NA											10	26					0	0	0	0
HRAS	3265	broad.mit.edu	37	11	534285	534285	+	Missense_Mutation	SNP	C	C	A	rs104894226		TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr11:534285C>A	uc001lpv.2	-	2	226	c.38G>T	c.(37-39)GGT>GTT	p.G13V	HRAS_uc010qvw.1_Missense_Mutation_p.G13V|HRAS_uc010qvx.1_Missense_Mutation_p.G13V|HRAS_uc010qvy.1_RNA	NM_005343	NP_005334	P01112	RASH_HUMAN	v-Ha-ras Harvey rat sarcoma viral oncogene	13	GTP.		G -> D (in FCSS).|G -> C (in FCSS).		activation of MAPKK activity|axon guidance|blood coagulation|cell cycle arrest|cellular senescence|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|mitotic cell cycle G1/S transition checkpoint|negative regulation of cell proliferation|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of DNA replication|positive regulation of epithelial cell proliferation|Ras protein signal transduction|synaptic transmission	cytosol|Golgi membrane|plasma membrane	GTP binding|GTPase activity|protein C-terminus binding	p.G13R(33)|p.G13V(10)|p.G13D(9)|p.G13S(9)|p.G13C(6)|p.G13G(1)|p.G12_G13insAG(1)		urinary_tract(174)|thyroid(155)|skin(126)|upper_aerodigestive_tract(112)|soft_tissue(37)|prostate(29)|salivary_gland(24)|cervix(23)|stomach(14)|pituitary(10)|lung(9)|haematopoietic_and_lymphoid_tissue(9)|breast(6)|testis(5)|endometrium(4)|bone(3)|large_intestine(2)|oesophagus(2)|penis(2)|kidney(1)|adrenal_gland(1)|thymus(1)	749		all_cancers(49;4.37e-09)|all_epithelial(84;2.09e-06)|Breast(177;0.000162)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.0538)|all_lung(207;0.0713)		all cancers(45;7.63e-28)|Epithelial(43;7.29e-27)|OV - Ovarian serous cystadenocarcinoma(40;7.15e-21)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0375)|LUSC - Lung squamous cell carcinoma(625;0.0703)	Sulindac(DB00605)	CTTGCCCACACCGCCGGCGCC	0.642		6	Mis		infrequent sarcomas|rare other types	rhadomyosarcoma|ganglioneuroblastoma|bladder			Costello_syndrome	HNSCC(11;0.0054)			10	14					4.69e-08	5.19e-08	1	0
MUC2	4583	broad.mit.edu	37	11	1093601	1093601	+	Missense_Mutation	SNP	G	G	A			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr11:1093601G>A	uc001lsx.1	+	31	12533	c.12506G>A	c.(12505-12507)GGC>GAC	p.G4169D		NM_002457	NP_002448	Q02817	MUC2_HUMAN	mucin 2 precursor	4169						inner mucus layer|outer mucus layer	protein binding			lung(1)|breast(1)	2		all_cancers(49;1.08e-07)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.191)		BRCA - Breast invasive adenocarcinoma(625;0.000207)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)	Pranlukast(DB01411)	ACACCCACCGGCACACAGACC	0.408		NA											3	23					0	0	0	0
OR51I1	390063	broad.mit.edu	37	11	5462199	5462199	+	Silent	SNP	G	G	C			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr11:5462199G>C	uc010qze.1	-	1	546	c.546C>G	c.(544-546)CTC>CTG	p.L182L	HBG2_uc001mak.1_Intron|HBE1_uc001mam.1_Intron|OR51B5_uc001maq.1_Intron	NM_001005288	NP_001005288	Q9H343	O51I1_HUMAN	olfactory receptor, family 51, subfamily I,	182	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;1.92e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GATCTGGATGGAGACAGTAGG	0.433		NA											14	22					0	0	0	0
OR6A2	8590	broad.mit.edu	37	11	6816910	6816910	+	Silent	SNP	C	C	G			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr11:6816910C>G	uc001mes.1	-	1	230	c.30G>C	c.(28-30)GTG>GTC	p.V10V		NM_003696	NP_003687	O95222	OR6A2_HUMAN	olfactory receptor, family 6, subfamily A,	10	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(3)|central_nervous_system(1)|pancreas(1)	5		Medulloblastoma(188;0.0523)|all_neural(188;0.236)		Epithelial(150;4.78e-08)|BRCA - Breast invasive adenocarcinoma(625;0.129)		CAAACTCACTCACTCTCCCAC	0.512		NA											13	41					0	0	0	0
OR10A2	341276	broad.mit.edu	37	11	6891679	6891679	+	Missense_Mutation	SNP	C	C	T			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr11:6891679C>T	uc001meu.1	+	1	694	c.694C>T	c.(694-696)CTC>TTC	p.L232F		NM_001004460	NP_001004460	Q9H208	O10A2_HUMAN	olfactory receptor, family 10, subfamily A,	232	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)	1		Medulloblastoma(188;0.0523)|all_neural(188;0.236)		Epithelial(150;4.89e-08)|BRCA - Breast invasive adenocarcinoma(625;0.13)		TTCCTCACACCTCCTTGTTGT	0.423		NA											109	46					0	0	0	0
ZNF215	7762	broad.mit.edu	37	11	6977464	6977464	+	Missense_Mutation	SNP	G	G	A	rs139686178		TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr11:6977464G>A	uc001mey.2	+	7	1844	c.1256G>A	c.(1255-1257)CGT>CAT	p.R419H	ZNF215_uc010raw.1_3'UTR|ZNF215_uc010rax.1_Missense_Mutation_p.R181H|ZNF215_uc001mez.1_Intron	NM_013250	NP_037382	Q9UL58	ZN215_HUMAN	zinc finger protein 215	419	C2H2-type 2.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0				Epithelial(150;6.33e-08)|BRCA - Breast invasive adenocarcinoma(625;0.134)		TTCAACCGACGTACAAACCTT	0.408		NA											20	30					0	0	0	0
ABCC8	6833	broad.mit.edu	37	11	17428294	17428294	+	Silent	SNP	C	C	T			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr11:17428294C>T	uc001mnc.2	-	26	3330	c.3204G>A	c.(3202-3204)ACG>ACA	p.T1068T		NM_000352	NP_000343	Q09428	ABCC8_HUMAN	ATP-binding cassette, sub-family C, member 8	1068	ABC transmembrane type-1 2.|Extracellular (By similarity).				carbohydrate metabolic process|energy reserve metabolic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium ion transmembrane transporter activity|sulfonylurea receptor activity			ovary(1)	1				READ - Rectum adenocarcinoma(2;0.0325)|Colorectal(2;0.1)	Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)|Gliclazide(DB01120)|Mitiglinide(DB01252)|Nateglinide(DB00731)|Repaglinide(DB00912)	TGCAGAGCACCGTGAACACCA	0.602		NA											28	18					0	0	0	0
CHST1	8534	broad.mit.edu	37	11	45671567	45671567	+	Missense_Mutation	SNP	C	C	T			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr11:45671567C>T	uc001mys.1	-	4	1578	c.907G>A	c.(907-909)GAG>AAG	p.E303K		NM_003654	NP_003645	O43916	CHST1_HUMAN	carbohydrate (keratan sulfate Gal-6)	303	Lumenal (Potential).				galactose metabolic process|inflammatory response|keratan sulfate metabolic process	Golgi membrane|integral to membrane	keratan sulfotransferase activity			skin(4)|pancreas(1)	5				GBM - Glioblastoma multiforme(35;3e-06)|BRCA - Breast invasive adenocarcinoma(625;0.0781)		GCCAGGTCCTCGTAGCGCACC	0.627		NA											35	23					0	0	0	0
OR5T1	390155	broad.mit.edu	37	11	56043262	56043262	+	Missense_Mutation	SNP	A	A	G			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr11:56043262A>G	uc001nio.1	+	1	148	c.148A>G	c.(148-150)ACT>GCT	p.T50A		NM_001004745	NP_001004745	Q8NG75	OR5T1_HUMAN	olfactory receptor, family 5, subfamily T,	50	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|pancreas(1)	3	Esophageal squamous(21;0.00448)					CTATCTATTCACTCTAATAGG	0.338		NA											19	49					0	0	0	0
PC	5091	broad.mit.edu	37	11	66618354	66618354	+	Missense_Mutation	SNP	A	A	G			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr11:66618354A>G	uc001ojn.1	-	16	2313	c.2264T>C	c.(2263-2265)CTG>CCG	p.L755P	PC_uc001ojo.1_Missense_Mutation_p.L755P|PC_uc001ojp.1_Missense_Mutation_p.L755P|PC_uc001ojm.1_5'Flank	NM_022172	NP_071504	P11498	PYC_HUMAN	pyruvate carboxylase precursor	755	Carboxyltransferase.				gluconeogenesis|lipid biosynthetic process	mitochondrial matrix	ATP binding|biotin binding|biotin carboxylase activity|metal ion binding|pyruvate carboxylase activity			ovary(2)|lung(1)|kidney(1)	4		Melanoma(852;0.0525)		Lung(977;0.153)|LUSC - Lung squamous cell carcinoma(976;0.227)	Biotin(DB00121)|Pyruvic acid(DB00119)	GGAGCTGACCAGCATGGTGCA	0.662		NA											7	13					0	0	0	0
ZBTB16	7704	broad.mit.edu	37	11	113934865	113934865	+	Silent	SNP	G	G	T			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr11:113934865G>T	uc001pop.2	+	2	1107	c.843G>T	c.(841-843)GGG>GGT	p.G281G	ZBTB16_uc001poo.1_Silent_p.G281G|ZBTB16_uc001poq.2_Silent_p.G281G	NM_006006	NP_005997	Q05516	ZBT16_HUMAN	promyelocytic leukemia zinc finger protein	281					apoptosis|central nervous system development|mesonephros development|myeloid cell differentiation|negative regulation of myeloid cell differentiation|negative regulation of transcription, DNA-dependent	nuclear speck|PML body|transcriptional repressor complex	protein homodimerization activity|zinc ion binding			central_nervous_system(1)|skin(1)	2		all_cancers(61;3.79e-18)|all_epithelial(67;2.32e-10)|all_hematologic(158;2.96e-05)|Melanoma(852;0.000362)|Acute lymphoblastic leukemia(157;0.00108)|Breast(348;0.0104)|all_neural(223;0.0294)|Prostate(24;0.0318)|Medulloblastoma(222;0.0438)		BRCA - Breast invasive adenocarcinoma(274;6.75e-06)|Epithelial(105;0.000181)|all cancers(92;0.0018)		AGGGGCCTGGGACCCCGACTC	0.647		NA											7	21					0.000274275	0.000290243	1	0
KRT78	196374	broad.mit.edu	37	12	53238435	53238435	+	Missense_Mutation	SNP	C	C	G			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr12:53238435C>G	uc001sbc.1	-	5	893	c.829G>C	c.(829-831)GAC>CAC	p.D277H		NM_173352	NP_775487	Q8N1N4	K2C78_HUMAN	keratin 5b	277	Linker 12.|Rod.					keratin filament	protein binding|structural molecule activity			ovary(2)	2						CTGCTGAAGTCCAGGTAGCGG	0.627		NA											23	39					0	0	0	0
C12orf51	283450	broad.mit.edu	37	12	112602002	112602002	+	Silent	SNP	G	G	A			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr12:112602002G>A	uc009zwc.2	-	66	11364	c.11346C>T	c.(11344-11346)AGC>AGT	p.S3782S		NM_001109662	NP_001103132			chromosome 12 open reading frame 51											ovary(1)|lung(1)	2						GCTTGTTGGGGCTGTCAGGGC	0.652		NA											16	33					0	0	0	0
FBXO21	23014	broad.mit.edu	37	12	117595803	117595803	+	Silent	SNP	C	C	A			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr12:117595803C>A	uc001twk.2	-	10	1452	c.1413G>T	c.(1411-1413)CTG>CTT	p.L471L	FBXO21_uc001twj.2_Silent_p.L464L|FBXO21_uc009zwq.2_Silent_p.L404L|FBXO21_uc001twl.1_Silent_p.L84L	NM_033624	NP_296373	O94952	FBX21_HUMAN	F-box only protein 21 isoform 1	471					ubiquitin-dependent protein catabolic process	ubiquitin ligase complex	ubiquitin-protein ligase activity			kidney(1)	1	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.0291)		TGTGCTGCACCAGGTAGCCCA	0.532		NA											61	166					1.08e-31	1.24e-31	1	0
ATP12A	479	broad.mit.edu	37	13	25266965	25266965	+	Silent	SNP	A	A	G			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr13:25266965A>G	uc001upp.2	+	10	1495	c.1308A>G	c.(1306-1308)TTA>TTG	p.L436L	ATP12A_uc010aaa.2_Silent_p.L442L	NM_001676	NP_001667	P54707	AT12A_HUMAN	hydrogen/potassium-exchanging ATPase 12A	436	Cytoplasmic (Potential).				ATP biosynthetic process	hydrogen:potassium-exchanging ATPase complex	ATP binding|hydrogen:potassium-exchanging ATPase activity|metal ion binding			ovary(2)|central_nervous_system(2)|large_intestine(1)|breast(1)	6		Lung SC(185;0.0225)|Breast(139;0.077)		all cancers(112;0.0307)|Epithelial(112;0.086)|OV - Ovarian serous cystadenocarcinoma(117;0.228)	Esomeprazole(DB00736)|Pantoprazole(DB00213)	GGGCCTCCTTATCCAAGATAA	0.483		NA											57	147					0	0	0	0
MTUS2	23281	broad.mit.edu	37	13	29855999	29855999	+	Missense_Mutation	SNP	G	G	A			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr13:29855999G>A	uc001usl.3	+	4	2891	c.2833G>A	c.(2833-2835)GCT>ACT	p.A945T		NM_001033602	NP_001028774	Q5JR59	MTUS2_HUMAN	hypothetical protein LOC23281 isoform a	935	Localization to the growing distal tip of microtubules.|Mediates interaction with MAPRE1.					cytoplasm|microtubule	microtubule binding|protein homodimerization activity				0						TTCCACACCCGCTGGTAAGAC	0.542		NA											16	43					0	0	0	0
SLITRK1	114798	broad.mit.edu	37	13	84453669	84453669	+	Silent	SNP	C	C	T			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr13:84453669C>T	uc001vlk.2	-	1	2860	c.1974G>A	c.(1972-1974)GCG>GCA	p.A658A		NM_052910	NP_443142	Q96PX8	SLIK1_HUMAN	slit and trk like 1 protein precursor	658	Cytoplasmic (Potential).					integral to membrane				ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	5	Medulloblastoma(90;0.18)	Breast(118;0.212)		GBM - Glioblastoma multiforme(99;0.07)		TAATCTCGGACGCGGAGGAGT	0.552		NA											9	20					0	0	0	0
SLITRK5	26050	broad.mit.edu	37	13	88329806	88329806	+	Silent	SNP	C	C	T			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr13:88329806C>T	uc001vln.2	+	2	2382	c.2163C>T	c.(2161-2163)GGC>GGT	p.G721G	SLITRK5_uc010tic.1_Silent_p.G480G	NM_015567	NP_056382	O94991	SLIK5_HUMAN	SLIT and NTRK-like family, member 5 precursor	721	Cytoplasmic (Potential).					integral to membrane				ovary(2)|pancreas(2)|central_nervous_system(1)	5	all_neural(89;0.101)|Medulloblastoma(90;0.163)					GCGGCGGCGGCGGCACGGGCG	0.652		NA											16	33					0	0	0	0
NAA30	122830	broad.mit.edu	37	14	57857726	57857726	+	Silent	SNP	T	T	G			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr14:57857726T>G	uc001xcx.3	+	2	205	c.51T>G	c.(49-51)CCT>CCG	p.P17P	NAA30_uc010trk.1_Intron|NAA30_uc010aow.2_Intron	NM_001011713	NP_001011713	Q147X3	NAA30_HUMAN	N-acetyltransferase 12	17	Pro-rich.					cytoplasm	peptide alpha-N-acetyltransferase activity			skin(1)	1						CACCAGCACCTCCGGCCCCGG	0.721		NA											4	10					0	0	0	0
CPSF2	53981	broad.mit.edu	37	14	92628079	92628079	+	Silent	SNP	C	C	T			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr14:92628079C>T	uc001yah.1	+	16	2577	c.2340C>T	c.(2338-2340)GCC>GCT	p.A780A		NM_017437	NP_059133	Q9P2I0	CPSF2_HUMAN	cleavage and polyadenylation specific factor 2	780					histone mRNA 3'-end processing|mRNA export from nucleus|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	mRNA cleavage and polyadenylation specificity factor complex	hydrolase activity|protein binding|RNA binding			ovary(2)	2		all_cancers(154;0.0766)		COAD - Colon adenocarcinoma(157;0.222)		AACAATATGCCATTGTATAAA	0.338		NA											4	18					0	0	0	0
CGNL1	84952	broad.mit.edu	37	15	57731561	57731561	+	Missense_Mutation	SNP	C	C	T			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr15:57731561C>T	uc002aeg.2	+	2	1440	c.1364C>T	c.(1363-1365)TCA>TTA	p.S455L	CGNL1_uc010bfw.2_Missense_Mutation_p.S455L	NM_032866	NP_116255	Q0VF96	CGNL1_HUMAN	cingulin-like 1	455	Head.					myosin complex|tight junction	motor activity			skin(6)|ovary(4)|central_nervous_system(1)	11				all cancers(107;0.121)|GBM - Glioblastoma multiforme(80;0.186)		CACGGGGCTTCATGTGCCCAC	0.622		NA											13	23					0	0	0	0
KIAA0101	9768	broad.mit.edu	37	15	64669065	64669065	+	Missense_Mutation	SNP	C	C	T			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr15:64669065C>T	uc002ank.2	-	3	299	c.167G>A	c.(166-168)CGC>CAC	p.R56H	KIAA0101_uc002anl.2_Intron	NM_014736	NP_055551	Q15004	PAF_HUMAN	hypothetical protein LOC9768 isoform 1	56						mitochondrion|nucleus				central_nervous_system(1)	1						GGGAGTTGGGCGCACGCAAAC	0.393		NA											13	28					0	0	0	0
KIAA1199	57214	broad.mit.edu	37	15	81181917	81181917	+	Missense_Mutation	SNP	G	G	A			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr15:81181917G>A	uc002bfw.1	+	9	1330	c.1070G>A	c.(1069-1071)CGT>CAT	p.R357H	KIAA1199_uc010unn.1_Missense_Mutation_p.R357H	NM_018689	NP_061159	Q8WUJ3	K1199_HUMAN	KIAA1199 precursor	357										upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3						ATATGCAATCGTCCCATTGAT	0.348		NA											13	41					0	0	0	0
IFT140	9742	broad.mit.edu	37	16	1657244	1657244	+	Missense_Mutation	SNP	C	C	A			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr16:1657244C>A	uc002cmb.2	-	3	386	c.24G>T	c.(22-24)CAG>CAT	p.Q8H		NM_014714	NP_055529	Q96RY7	IF140_HUMAN	intraflagellar transport 140	8										ovary(3)|pancreas(1)|skin(1)	5		Hepatocellular(780;0.219)				GGGCTTCTATCTGGTGGTCAT	0.488		NA											19	72					1.16e-05	1.24e-05	1	0
NUBP2	10101	broad.mit.edu	37	16	1836869	1836869	+	Missense_Mutation	SNP	C	C	T			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr16:1836869C>T	uc002cmw.3	+	3	336	c.247C>T	c.(247-249)CGG>TGG	p.R83W	NUBP2_uc002cmx.3_Intron|NUBP2_uc010brx.2_Missense_Mutation_p.R23W	NM_012225	NP_036357	Q9Y5Y2	NUBP2_HUMAN	nucleotide binding protein 2 (MinD homolog, E.	83						microtubule organizing center|nucleus	4 iron, 4 sulfur cluster binding|ATP binding|metal ion binding|protein binding				0						CTTCCTGGACCGGGAGCAGAG	0.677		NA											8	29					0	0	0	0
GPT2	84706	broad.mit.edu	37	16	46934667	46934667	+	Missense_Mutation	SNP	G	G	T			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr16:46934667G>T	uc002eel.2	+	4	501	c.407G>T	c.(406-408)CGG>CTG	p.R136L	GPT2_uc002eem.2_Missense_Mutation_p.R36L	NM_133443	NP_597700	Q8TD30	ALAT2_HUMAN	glutamic pyruvate transaminase 2 isoform 1	136					2-oxoglutarate metabolic process|cellular amino acid biosynthetic process|L-alanine metabolic process	mitochondrial matrix	L-alanine:2-oxoglutarate aminotransferase activity|pyridoxal phosphate binding			ovary(1)|skin(1)	2		all_cancers(37;0.0276)|all_epithelial(9;0.0498)|all_lung(18;0.0522)			L-Alanine(DB00160)|L-Glutamic Acid(DB00142)|Pyridoxal Phosphate(DB00114)	AAACGTGCCCGGCGGATCCTG	0.617		NA											11	25					2.81e-09	3.14e-09	1	0
SALL1	6299	broad.mit.edu	37	16	51175913	51175913	+	Missense_Mutation	SNP	C	C	T			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr16:51175913C>T	uc010vgs.1	-	2	251	c.220G>A	c.(220-222)GTA>ATA	p.V74I	SALL1_uc010vgr.1_5'UTR|SALL1_uc010cbv.2_Intron	NM_002968	NP_002959	Q9NSC2	SALL1_HUMAN	sal-like 1 isoform a	74					adrenal gland development|branching involved in ureteric bud morphogenesis|embryonic digestive tract development|embryonic digit morphogenesis|gonad development|histone deacetylation|inductive cell-cell signaling|mesenchymal to epithelial transition involved in metanephros morphogenesis|negative regulation of transcription from RNA polymerase II promoter|olfactory bulb interneuron differentiation|olfactory bulb mitral cell layer development|olfactory nerve development|outer ear morphogenesis|pituitary gland development|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway|ureteric bud invasion|ventricular septum development	chromocenter|cytoplasm|heterochromatin|nucleus	beta-catenin binding|DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(5)|ovary(3)	8		all_cancers(37;0.0322)	COAD - Colon adenocarcinoma(2;0.24)			TTTTCATTTACGATTAAAACT	0.448		NA											27	57					0	0	0	0
ZNF319	57567	broad.mit.edu	37	16	58031659	58031659	+	Missense_Mutation	SNP	C	C	T			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr16:58031659C>T	uc002emx.1	-	2	1134	c.511G>A	c.(511-513)GAG>AAG	p.E171K		NM_020807	NP_065858	Q9P2F9	ZN319_HUMAN	zinc finger protein 319	171					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						TCCGCTGCCTCAGCTGGCTTG	0.622		NA											46	88					0	0	0	0
CDH11	1009	broad.mit.edu	37	16	65006889	65006889	+	Silent	SNP	C	C	T			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr16:65006889C>T	uc002eoi.2	-	9	1742	c.1308G>A	c.(1306-1308)GAG>GAA	p.E436E	CDH11_uc010cdn.2_Intron|CDH11_uc002eoj.2_Silent_p.E436E|CDH11_uc010vin.1_Silent_p.E310E	NM_001797	NP_001788	P55287	CAD11_HUMAN	cadherin 11, type 2 preproprotein	436	Cadherin 4.|Extracellular (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion|ossification|skeletal system development	integral to membrane|plasma membrane	calcium ion binding|protein binding			lung(10)|ovary(3)|skin(1)	14		Ovarian(137;0.0973)		OV - Ovarian serous cystadenocarcinoma(108;0.205)		TAAAACCATCCTCTGGATTAA	0.413		NA	T	USP6	aneurysmal bone cysts					TSP Lung(24;0.17)			10	44					0	0	0	0
OR1D2	4991	broad.mit.edu	37	17	2995717	2995717	+	Missense_Mutation	SNP	T	T	C			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr17:2995717T>C	uc010vrb.1	-	1	574	c.574A>G	c.(574-576)ATT>GTT	p.I192V		NM_002548	NP_002539	P34982	OR1D2_HUMAN	olfactory receptor, family 1, subfamily D,	192	Extracellular (Potential).				cellular component movement|chemotaxis|protein import into nucleus, translocation|sensory perception of smell|single fertilization	integral to plasma membrane	olfactory receptor activity			ovary(1)	1						TTAATCTGAATGTTGGAACAT	0.448		NA											14	39					0	0	0	0
SPNS3	201305	broad.mit.edu	37	17	4351571	4351571	+	Missense_Mutation	SNP	G	G	A			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr17:4351571G>A	uc002fxt.2	+	6	787	c.743G>A	c.(742-744)TGT>TAT	p.C248Y	SPNS3_uc002fxu.2_Missense_Mutation_p.C121Y	NM_182538	NP_872344	Q6ZMD2	SPNS3_HUMAN	spinster homolog 3	248					lipid transport|transmembrane transport	integral to membrane				large_intestine(1)	1						AGCAGCTGGTGTGAGGACGTC	0.612		NA											13	13					0	0	0	0
KRT14	3861	broad.mit.edu	37	17	39739633	39739633	+	Missense_Mutation	SNP	C	C	T			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr17:39739633C>T	uc002hxf.1	-	6	1189	c.1128G>A	c.(1126-1128)ATG>ATA	p.M376I	JUP_uc010wfs.1_Intron|KRT14_uc010cxp.1_Intron	NM_000526	NP_000517	P02533	K1C14_HUMAN	keratin 14	376	Rod.|Coil 2.				epidermis development|hemidesmosome assembly|intermediate filament bundle assembly	cytosol|keratin filament|mitochondrion|nucleus	protein binding|structural constituent of cytoskeleton			ovary(1)	1		Breast(137;0.000307)				CGCTGCCAATCATCTCCTGGA	0.597		NA											12	27					0	0	0	0
BAIAP2	10458	broad.mit.edu	37	17	79073793	79073793	+	Silent	SNP	C	C	T	rs146015006	byFrequency	TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr17:79073793C>T	uc002jzg.2	+	7	663	c.555C>T	c.(553-555)ACC>ACT	p.T185T	BAIAP2_uc002jyz.3_Silent_p.T185T|BAIAP2_uc002jza.2_Silent_p.T185T|BAIAP2_uc002jzc.2_Silent_p.T185T|BAIAP2_uc002jzb.2_5'UTR|BAIAP2_uc002jzd.2_Silent_p.T185T|BAIAP2_uc002jzf.2_Silent_p.T185T|BAIAP2_uc002jze.2_Silent_p.T218T|BAIAP2_uc010wuh.1_Silent_p.T107T|BAIAP2_uc002jzh.2_Silent_p.T186T|BAIAP2_uc010wui.1_Silent_p.T48T	NM_017451	NP_059345	Q9UQB8	BAIP2_HUMAN	BAI1-associated protein 2 isoform 2	185	IMD.				axonogenesis|filopodium assembly|insulin receptor signaling pathway|regulation of actin cytoskeleton organization|response to bacterium	cell junction|cytoskeleton|cytosol|filopodium|nucleus|ruffle	cytoskeletal adaptor activity|proline-rich region binding|protein C-terminus binding|SH3 domain binding				0	all_neural(118;0.101)		BRCA - Breast invasive adenocarcinoma(99;0.0228)|OV - Ovarian serous cystadenocarcinoma(97;0.0524)			GCTACAAGACCGCACTGACAG	0.617		NA											3	39					0	0	0	0
ZNF532	55205	broad.mit.edu	37	18	56620896	56620896	+	Silent	SNP	G	G	A			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr18:56620896G>A	uc002lho.2	+	8	3562	c.3015G>A	c.(3013-3015)AAG>AAA	p.K1005K	ZNF532_uc002lhp.2_Silent_p.K1003K|ZNF532_uc010xeg.1_Silent_p.K1003K|ZNF532_uc002lhr.2_Silent_p.K1003K|ZNF532_uc002lhs.2_Silent_p.K1003K|ZNF532_uc010xeh.1_Silent_p.K97K	NM_018181	NP_060651	Q9HCE3	ZN532_HUMAN	zinc finger protein 532	1005					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|skin(1)	2						AATTGGAAAAGAAATCTCCAT	0.428		NA											24	49					0	0	0	0
ODF3L2	284451	broad.mit.edu	37	19	463990	463990	+	Missense_Mutation	SNP	C	C	T			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr19:463990C>T	uc002lor.2	-	4	960	c.724G>A	c.(724-726)GCC>ACC	p.A242T	SHC2_uc002loq.3_5'Flank|ODF3L2_uc010drp.2_Missense_Mutation_p.A206T	NM_182577	NP_872383	Q3SX64	OD3L2_HUMAN	outer dense fiber of sperm tails 3-like 2	242	DUF1309 3.|Pro-rich.										0						GGGCAGTGGGCGCCAGGGCCG	0.607		NA											4	13					0	0	0	0
OR1M1	125963	broad.mit.edu	37	19	9204511	9204511	+	Silent	SNP	C	C	T			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr19:9204511C>T	uc010xkj.1	+	1	591	c.591C>T	c.(589-591)ATC>ATT	p.I197I		NM_001004456	NP_001004456	Q8NGA1	OR1M1_HUMAN	olfactory receptor, family 1, subfamily M,	197	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(3)	3						TGAATAGGATCTTCATCCTCA	0.567		NA											19	57					0	0	0	0
ILVBL	10994	broad.mit.edu	37	19	15230101	15230101	+	Missense_Mutation	SNP	C	C	G			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr19:15230101C>G	uc002nam.2	-	9	1048	c.927G>C	c.(925-927)GAG>GAC	p.E309D	ILVBL_uc010xof.1_5'Flank|ILVBL_uc010dzw.2_Missense_Mutation_p.E202D	NM_006844	NP_006835	A1L0T0	ILVBL_HUMAN	ilvB (bacterial acetolactate synthase)-like	309						integral to membrane	magnesium ion binding|thiamine pyrophosphate binding|transferase activity			ovary(2)	2						CACCCAAGGTCTCCACGGCAG	0.672		NA											10	36					0	0	0	0
ZNF382	84911	broad.mit.edu	37	19	37118156	37118156	+	Missense_Mutation	SNP	C	C	T			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr19:37118156C>T	uc002oek.2	+	5	1470	c.1357C>T	c.(1357-1359)CTC>TTC	p.L453F	ZNF382_uc010efa.2_Missense_Mutation_p.L404F|ZNF382_uc010efb.2_Missense_Mutation_p.L452F|ZNF382_uc002oel.2_Missense_Mutation_p.L452F	NM_032825	NP_116214	Q96SR6	ZN382_HUMAN	zinc finger protein 382	453	Required for transcriptional repression activity; probably mediates sequence- specific DNA-binding (By similarity).|C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	Esophageal squamous(110;0.198)		COAD - Colon adenocarcinoma(19;0.0454)|Colorectal(19;0.065)			AACCCTCACTCTCCACCAGAG	0.453		NA											9	35					0	0	0	0
AXL	558	broad.mit.edu	37	19	41726662	41726662	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr19:41726662G>A	uc010ehj.2	+	2	397	c.207G>A	c.(205-207)TGG>TGA	p.W69*	CYP2F1_uc010xvw.1_Intron|AXL_uc010ehi.1_Nonsense_Mutation_p.W69*|AXL_uc010ehk.2_Nonsense_Mutation_p.W69*	NM_021913	NP_068713	P30530	UFO_HUMAN	AXL receptor tyrosine kinase isoform 1	69	Extracellular (Potential).|Interaction with GAS6.|Ig-like C2-type 1.					integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(4)|stomach(3)|ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)	13						AGGTACATTGGCTTCGGGATG	0.627		NA											12	28					0	0	0	0
DMRTC2	63946	broad.mit.edu	37	19	42351824	42351824	+	Missense_Mutation	SNP	C	C	T			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr19:42351824C>T	uc002ors.2	+	3	328	c.245C>T	c.(244-246)GCT>GTT	p.A82V	DMRTC2_uc002orr.1_5'UTR|DMRTC2_uc010xwe.1_Missense_Mutation_p.A82V	NM_001040283	NP_001035373	Q8IXT2	DMRTD_HUMAN	DMRT-like family C2	82	DM.				cell differentiation|sex differentiation	nucleus	DNA binding|metal ion binding|sequence-specific DNA binding transcription factor activity				0						AGGGTCATGGCTGCCCAGGTG	0.592		NA											5	4					0	0	0	0
ZC3H4	23211	broad.mit.edu	37	19	47575163	47575163	+	Missense_Mutation	SNP	G	G	T	rs149041592		TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr19:47575163G>T	uc002pga.3	-	13	2056	c.2018C>A	c.(2017-2019)CCC>CAC	p.P673H	ZC3H4_uc002pgb.1_Intron	NM_015168	NP_055983	Q9UPT8	ZC3H4_HUMAN	zinc finger CCCH-type containing 4	673	Pro-rich.						nucleic acid binding|zinc ion binding	p.P673L(1)		skin(4)|ovary(2)	6		all_cancers(25;3.3e-08)|all_epithelial(76;2.28e-06)|all_lung(116;7.86e-06)|Lung NSC(112;2.31e-05)|all_neural(266;0.026)|Ovarian(192;0.0392)|Breast(70;0.0889)		OV - Ovarian serous cystadenocarcinoma(262;5.76e-05)|all cancers(93;7.69e-05)|Epithelial(262;0.00354)|GBM - Glioblastoma multiforme(486;0.0372)		AGGGCCGTAGGGCATCATTGG	0.493		NA											6	16					0.00116845	0.00121976	1	0
SPHK2	56848	broad.mit.edu	37	19	49132292	49132292	+	Silent	SNP	G	G	A			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr19:49132292G>A	uc002pjr.2	+	7	1593	c.1227G>A	c.(1225-1227)CCG>CCA	p.P409P	SPHK2_uc010xzt.1_Silent_p.P350P|SPHK2_uc002pjs.2_Silent_p.P409P|SPHK2_uc002pjt.2_Silent_p.P203P|SPHK2_uc002pju.2_Intron|SPHK2_uc002pjv.2_Silent_p.P373P|SPHK2_uc002pjw.2_Silent_p.P471P	NM_020126	NP_064511	Q9NRA0	SPHK2_HUMAN	sphingosine kinase 2	409					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|anti-apoptosis|cell proliferation|sphinganine-1-phosphate biosynthetic process	cytosol|lysosomal membrane|membrane fraction	ATP binding|D-erythro-sphingosine kinase activity|diacylglycerol kinase activity|Ras GTPase binding|sphinganine kinase activity			lung(1)	1		all_lung(116;0.000125)|Lung NSC(112;0.000202)|all_epithelial(76;0.000283)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000102)|all cancers(93;0.000117)|GBM - Glioblastoma multiforme(486;0.00627)|Epithelial(262;0.0158)		Acccagccccgcccatggccc	0.343		NA											8	22					0	0	0	0
TULP2	7288	broad.mit.edu	37	19	49399725	49399725	+	Missense_Mutation	SNP	C	C	T			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr19:49399725C>T	uc002pkz.2	-	4	324	c.173G>A	c.(172-174)CGC>CAC	p.R58H		NM_003323	NP_003314	O00295	TULP2_HUMAN	tubby like protein 2	58					visual perception	cytoplasm|extracellular region				ovary(1)|kidney(1)|skin(1)	3		all_epithelial(76;5.29e-07)|all_lung(116;1.7e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.000259)|all cancers(93;0.000435)|Epithelial(262;0.0221)|GBM - Glioblastoma multiforme(486;0.0234)		CAGACAAGAGCGCCAAAGCCA	0.637		NA											17	29					0	0	0	0
APOB	338	broad.mit.edu	37	2	21233458	21233458	+	Silent	SNP	G	G	A			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr2:21233458G>A	uc002red.2	-	26	6410	c.6282C>T	c.(6280-6282)AAC>AAT	p.N2094N		NM_000384	NP_000375	P04114	APOB_HUMAN	apolipoprotein B precursor	2094	Heparin-binding.				cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			ovary(11)|skin(9)|central_nervous_system(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	TTCTCTGTACGTTTTCCAGTA	0.363		NA											10	40					0	0	0	0
UBXN2A	165324	broad.mit.edu	37	2	24222567	24222567	+	Missense_Mutation	SNP	G	G	A			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr2:24222567G>A	uc010exy.2	+	8	1078	c.610G>A	c.(610-612)GAA>AAA	p.E204K	UBXN2A_uc002rem.2_RNA|UBXN2A_uc002ren.2_Missense_Mutation_p.E204K|UBXN2A_uc010ykj.1_Missense_Mutation_p.E151K	NM_181713	NP_859064	P68543	UBX2A_HUMAN	UBX domain containing 4	204	UBX.										0						AGACTTCATTGAAAAATACCA	0.363		NA											19	36					0	0	0	0
DHX57	90957	broad.mit.edu	37	2	39065051	39065051	+	Missense_Mutation	SNP	C	C	T			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr2:39065051C>T	uc002rrf.2	-	13	2563	c.2464G>A	c.(2464-2466)GAT>AAT	p.D822N	DHX57_uc002rrd.3_Missense_Mutation_p.D206N|DHX57_uc002rre.2_Missense_Mutation_p.D255N	NM_198963	NP_945314	Q6P158	DHX57_HUMAN	DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57	822							ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding|zinc ion binding			ovary(1)|lung(1)|skin(1)	3		all_hematologic(82;0.248)				TTTTCAAAATCCATGATGGAC	0.358		NA											20	34					0	0	0	0
BUB1	699	broad.mit.edu	37	2	111419371	111419371	+	Silent	SNP	C	C	T			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr2:111419371C>T	uc002tgc.2	-	10	1117	c.1005G>A	c.(1003-1005)CTG>CTA	p.L335L	BUB1_uc010yxh.1_Silent_p.L315L|BUB1_uc010fkb.2_Silent_p.L335L|BUB1_uc002tgd.2_Silent_p.L335L	NM_004336	NP_004327	O43683	BUB1_HUMAN	budding uninhibited by benzimidazoles 1	335					apoptosis|cell division|chromosome segregation|interspecies interaction between organisms|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|regulation of sister chromatid cohesion	condensed chromosome kinetochore|cytosol	ATP binding|protein binding|protein serine/threonine kinase activity			lung(2)|breast(2)|stomach(1)|ovary(1)|kidney(1)	7		Ovarian(717;0.0822)		BRCA - Breast invasive adenocarcinoma(221;0.0556)		ATGGCGCTCTCAGTTCCTGCT	0.453		NA											25	48					0	0	0	0
IWS1	55677	broad.mit.edu	37	2	128262665	128262665	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr2:128262665G>A	uc002ton.2	-	3	1117	c.814C>T	c.(814-816)CGA>TGA	p.R272*	IWS1_uc010yzl.1_RNA|uc002too.1_5'Flank|IWS1_uc010fma.2_RNA	NM_017969	NP_060439	Q96ST2	IWS1_HUMAN	IWS1 homolog	272	Glu-rich.|2.|3 X approximate tandem repeats.				transcription, DNA-dependent	nucleus	DNA binding			ovary(1)	1	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0735)		TCACTGATTCGGGGTTTGGGA	0.522		NA											75	153					0	0	0	0
XIRP2	129446	broad.mit.edu	37	2	168103818	168103818	+	Missense_Mutation	SNP	C	C	A			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr2:168103818C>A	uc002udx.2	+	8	5934	c.5916C>A	c.(5914-5916)AAC>AAA	p.N1972K	XIRP2_uc010fpn.2_Intron|XIRP2_uc010fpo.2_Intron|XIRP2_uc010fpp.2_Intron|XIRP2_uc002udy.2_Missense_Mutation_p.N1797K|XIRP2_uc010fpq.2_Missense_Mutation_p.N1750K|XIRP2_uc010fpr.2_Intron|XIRP2_uc010fps.1_5'Flank	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	1797					actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14						TCCAGAGGAACAAAAATAGTC	0.458		NA											13	23					9.05e-12	1.02e-11	1	0
TTN	7273	broad.mit.edu	37	2	179529198	179529198	+	Missense_Mutation	SNP	A	A	G			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr2:179529198A>G	uc010zfk.1	-	13	1255	c.707T>C	c.(706-708)GTA>GCA	p.V236A	TTN_uc010zfg.1_Intron|TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Intron|TTN_uc010fre.1_Intron			Q8WZ42	TITIN_HUMAN	SubName: Full=Titin; Flags: Fragment;	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTTGACAGGTACAACTTCAGC	0.403		NA											33	72					0	0	0	0
TTN	7273	broad.mit.edu	37	2	179549471	179549471	+	Missense_Mutation	SNP	C	C	T			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr2:179549471C>T	uc010zfg.1	-	128	29052	c.28828G>A	c.(28828-28830)GAA>AAA	p.E9610K	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.E6271K|TTN_uc010fre.1_Intron	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	10537							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTTGGCTCTTCTGGCACTTAA	0.388		NA											12	26					0	0	0	0
CASP8	841	broad.mit.edu	37	2	202149659	202149659	+	Missense_Mutation	SNP	A	A	G			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr2:202149659A>G	uc002uxr.1	+	9	1132	c.923A>G	c.(922-924)GAC>GGC	p.D308G	CASP8_uc002uxp.1_Missense_Mutation_p.D325G|CASP8_uc002uxq.1_Missense_Mutation_p.D293G|CASP8_uc002uxt.1_Missense_Mutation_p.D367G|CASP8_uc002uxu.1_RNA|CASP8_uc002uxw.1_Missense_Mutation_p.D293G|CASP8_uc002uxy.1_Intron|CASP8_uc002uxx.1_Intron|CASP8_uc010ftf.2_Missense_Mutation_p.D224G	NM_033355	NP_203519	Q14790	CASP8_HUMAN	caspase 8 isoform B precursor	308					activation of caspase activity|activation of pro-apoptotic gene products|cellular component disassembly involved in apoptosis|cellular response to mechanical stimulus|induction of apoptosis by extracellular signals|induction of apoptosis by intracellular signals|positive regulation of I-kappaB kinase/NF-kappaB cascade|proteolysis involved in cellular protein catabolic process|response to tumor necrosis factor	centrosome|cytosol|mitochondrial outer membrane	cysteine-type endopeptidase activity|protein binding|protein binding			upper_aerodigestive_tract(2)|ovary(1)|breast(1)|skin(1)	5						AGTAACATGGACTGCTTCATC	0.468		NA								HNSCC(4;0.00038)			62	38					0	0	0	0
INHA	3623	broad.mit.edu	37	2	220439822	220439822	+	Silent	SNP	T	T	C	rs139608664	byFrequency	TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr2:220439822T>C	uc002vmk.1	+	2	819	c.675T>C	c.(673-675)AGT>AGC	p.S225S		NM_002191	NP_002182	P05111	INHA_HUMAN	inhibin alpha subunit precursor	225					cell cycle arrest|cell surface receptor linked signaling pathway|cell-cell signaling|erythrocyte differentiation|hemoglobin biosynthetic process|induction of apoptosis|negative regulation of B cell differentiation|negative regulation of follicle-stimulating hormone secretion|negative regulation of interferon-gamma biosynthetic process|negative regulation of macrophage differentiation|negative regulation of phosphorylation|nervous system development|ovarian follicle development|positive regulation of follicle-stimulating hormone secretion|regulation of cell proliferation|response to external stimulus|skeletal system development	inhibin A complex|inhibin-betaglycan-ActRII complex	cytokine activity|growth factor activity|hormone activity|signal transducer activity			ovary(1)	1		Renal(207;0.0183)		Epithelial(149;4.58e-07)|all cancers(144;4.31e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00802)		GACCACCCAGTGGAGGGGAGA	0.692		NA											26	13					0	0	0	0
ESPNL	339768	broad.mit.edu	37	2	239040266	239040266	+	Missense_Mutation	SNP	C	C	G			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr2:239040266C>G	uc002vxq.3	+	9	3021	c.2911C>G	c.(2911-2913)CGC>GGC	p.R971G	ESPNL_uc010fyw.2_Missense_Mutation_p.R667G	NM_194312	NP_919288	Q6ZVH7	ESPNL_HUMAN	espin-like	971										pancreas(1)	1		Breast(86;7.61e-05)|Renal(207;0.00183)|Ovarian(221;0.0481)|all_hematologic(139;0.158)|all_lung(227;0.198)|Melanoma(123;0.203)|Hepatocellular(293;0.244)		Epithelial(121;4.71e-24)|OV - Ovarian serous cystadenocarcinoma(60;3.02e-12)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;5.63e-08)|BRCA - Breast invasive adenocarcinoma(100;0.000109)|Lung(119;0.0108)|LUSC - Lung squamous cell carcinoma(224;0.0253)		GCTGGGGTCCCGCTCCCAGCA	0.652		NA											19	10					0	0	0	0
BCAS1	8537	broad.mit.edu	37	20	52644969	52644969	+	Missense_Mutation	SNP	C	C	T			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr20:52644969C>T	uc002xws.2	-	4	1023	c.685G>A	c.(685-687)GGC>AGC	p.G229S	BCAS1_uc010zzb.1_Missense_Mutation_p.G132S|BCAS1_uc010gim.2_Missense_Mutation_p.G132S|BCAS1_uc002xwt.2_Missense_Mutation_p.G229S|BCAS1_uc010gil.1_Missense_Mutation_p.G229S|BCAS1_uc010zzc.1_Missense_Mutation_p.G132S	NM_003657	NP_003648	O75363	BCAS1_HUMAN	breast carcinoma amplified sequence 1	229						cytoplasm	protein binding			ovary(2)|central_nervous_system(1)	3	Breast(2;9.53e-15)|Lung NSC(4;5.57e-06)|all_lung(4;1.44e-05)		STAD - Stomach adenocarcinoma(23;0.116)|Colorectal(105;0.198)			CCTGATAAGCCAGGAACCTCA	0.532		NA											52	144					0	0	0	0
RGL4	266747	broad.mit.edu	37	22	24035110	24035110	+	Missense_Mutation	SNP	G	G	A			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr22:24035110G>A	uc002zxn.2	+	3	1798	c.628G>A	c.(628-630)GAG>AAG	p.E210K	LOC91316_uc002zxh.3_RNA|LOC91316_uc002zxi.3_RNA|LOC91316_uc002zxk.3_Intron|LOC91316_uc010gua.2_Intron|LOC91316_uc002zxl.3_Intron|LOC91316_uc011aiz.1_Intron|LOC91316_uc002zxm.3_Intron|RGL4_uc002zxo.2_Missense_Mutation_p.E210K|RGL4_uc002zxp.1_Missense_Mutation_p.E74K|RGL4_uc002zxq.2_Missense_Mutation_p.E74K	NM_153615	NP_705843	Q8IZJ4	RGDSR_HUMAN	ral guanine nucleotide dissociation	210	Pro-rich.				small GTPase mediated signal transduction	cytoplasmic membrane-bounded vesicle	guanyl-nucleotide exchange factor activity			ovary(1)	1						CCAACCCAGTGAGGAGCTGCC	0.622		NA											8	31					0	0	0	0
C22orf13	83606	broad.mit.edu	37	22	24943916	24943916	+	Missense_Mutation	SNP	C	C	A			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr22:24943916C>A	uc003aah.2	-	3	570	c.254G>T	c.(253-255)TGT>TTT	p.C85F	C22orf13_uc003aal.2_Missense_Mutation_p.C141F|C22orf13_uc003aai.3_Missense_Mutation_p.C85F|C22orf13_uc003aaj.3_Missense_Mutation_p.C85F|C22orf13_uc003aak.3_Missense_Mutation_p.C141F	NM_031444	NP_113632	Q96NT3	CV013_HUMAN	chromosome 22 open reading frame 13	85											0						GGTCTGGGTACAGAAGCGGTG	0.602		NA											19	35					5.35e-07	5.87e-07	1	0
TTC21A	199223	broad.mit.edu	37	3	39178436	39178436	+	Missense_Mutation	SNP	C	C	T			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr3:39178436C>T	uc003cjc.2	+	24	3340	c.3163C>T	c.(3163-3165)CGC>TGC	p.R1055C	TTC21A_uc003cje.2_Missense_Mutation_p.R1056C|TTC21A_uc003cjd.2_RNA|TTC21A_uc011ayx.1_Missense_Mutation_p.R1007C|TTC21A_uc003cjf.2_Missense_Mutation_p.R176C	NM_145755	NP_665698	Q8NDW8	TT21A_HUMAN	tetratricopeptide repeat domain 21A isoform 2	1055	TPR 16.						binding			ovary(1)	1				KIRC - Kidney renal clear cell carcinoma(284;0.0588)|Kidney(284;0.0738)		GAACAAGGCACGCAAGGACAG	0.478		NA											10	58					0	0	0	0
MAP4	4134	broad.mit.edu	37	3	47912526	47912526	+	Missense_Mutation	SNP	G	G	A			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr3:47912526G>A	uc003csb.2	-	13	3162	c.2636C>T	c.(2635-2637)GCC>GTC	p.A879V	MAP4_uc003csc.3_Missense_Mutation_p.A879V|MAP4_uc003crw.2_Missense_Mutation_p.A11V|MAP4_uc003crx.2_Missense_Mutation_p.A139V|MAP4_uc011bbe.1_Missense_Mutation_p.A630V|MAP4_uc003cry.2_Missense_Mutation_p.A614V|MAP4_uc003csa.3_Missense_Mutation_p.A614V|MAP4_uc003crz.3_RNA|MAP4_uc003csd.2_Missense_Mutation_p.A614V	NM_002375	NP_002366	P27816	MAP4_HUMAN	microtubule-associated protein 4 isoform 1	879					negative regulation of microtubule depolymerization	cytoplasm|microtubule|microtubule associated complex	protein binding|structural molecule activity			ovary(2)|pancreas(1)	3				BRCA - Breast invasive adenocarcinoma(193;0.000721)|KIRC - Kidney renal clear cell carcinoma(197;0.00641)|Kidney(197;0.00736)		TGCAGCGGGGGCTGTCCCACT	0.587		NA											18	41					0	0	0	0
EPHA3	2042	broad.mit.edu	37	3	89498433	89498433	+	Missense_Mutation	SNP	C	C	G			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr3:89498433C>G	uc003dqy.2	+	14	2630	c.2405C>G	c.(2404-2406)ACG>AGG	p.T802R	EPHA3_uc010hon.1_RNA	NM_005233	NP_005224	P29320	EPHA3_HUMAN	ephrin receptor EphA3 isoform a precursor	802	Cytoplasmic (Potential).|Protein kinase.					extracellular region|integral to plasma membrane	ATP binding			lung(17)|ovary(7)|large_intestine(4)|central_nervous_system(2)|stomach(1)|skin(1)|pancreas(1)	33	all_cancers(8;0.0406)|Melanoma(1;0.00142)|all_epithelial(1;0.0612)	Lung NSC(201;0.0782)		LUSC - Lung squamous cell carcinoma(29;0.00344)|Lung(72;0.00942)		CGCAAGTTCACGTCAGCCAGC	0.438		NA								TSP Lung(6;0.00050)			25	71					0	0	0	0
GAP43	2596	broad.mit.edu	37	3	115395076	115395076	+	Missense_Mutation	SNP	G	G	C			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr3:115395076G>C	uc003ebq.2	+	2	633	c.247G>C	c.(247-249)GAA>CAA	p.E83Q	GAP43_uc003ebr.2_Missense_Mutation_p.E119Q	NM_002045	NP_002036	P17677	NEUM_HUMAN	growth associated protein 43 isoform 2	83					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|cell differentiation|nervous system development|regulation of filopodium assembly|regulation of growth|response to wounding	cell junction|filopodium membrane|growth cone membrane|synapse	calmodulin binding			ovary(1)	1				GBM - Glioblastoma multiforme(114;0.164)		GAAGAAGGGAGAAGGCACCAC	0.562		NA											10	21					0	0	0	0
DNAJB8	165721	broad.mit.edu	37	3	128181438	128181438	+	Silent	SNP	C	C	T			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr3:128181438C>T	uc003ekk.1	-	3	2312	c.651G>A	c.(649-651)TCG>TCA	p.S217S	uc003ekl.1_5'Flank	NM_153330	NP_699161	Q8NHS0	DNJB8_HUMAN	DnaJ homolog, subfamily B, member 8	217					protein folding		heat shock protein binding|unfolded protein binding				0				GBM - Glioblastoma multiforme(114;0.177)		TCACAGTCACCGACTTGAGCT	0.632		NA											28	67					0	0	0	0
LSG1	55341	broad.mit.edu	37	3	194392825	194392825	+	Missense_Mutation	SNP	G	G	A			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr3:194392825G>A	uc003fui.2	-	1	382	c.67C>T	c.(67-69)CGG>TGG	p.R23W		NM_018385	NP_060855	Q9H089	LSG1_HUMAN	large subunit GTPase 1	23					nuclear export|protein transport	Cajal body|endoplasmic reticulum	GTP binding|hydrolase activity				0	all_cancers(143;1.68e-08)|Ovarian(172;0.0634)		OV - Ovarian serous cystadenocarcinoma(49;4.34e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;7.55e-06)		CTTCGGCTCCGCTGAGTCTGA	0.597		NA											13	24					0	0	0	0
AFAP1	60312	broad.mit.edu	37	4	7795475	7795475	+	Silent	SNP	G	G	A			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr4:7795475G>A	uc003gkg.1	-	11	1618	c.1345C>T	c.(1345-1347)CTG>TTG	p.L449L	AFAP1_uc011bwk.1_Silent_p.L449L	NM_198595	NP_940997	Q8N556	AFAP1_HUMAN	actin filament associated protein 1	449						actin cytoskeleton|cytoplasm|focal adhesion	actin binding				0						TCATAGTGCAGAGCCTCCGGG	0.498		NA											23	74					0	0	0	0
SLIT2	9353	broad.mit.edu	37	4	20258327	20258327	+	Missense_Mutation	SNP	C	C	T			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr4:20258327C>T	uc003gpr.1	+	2	416	c.212C>T	c.(211-213)ACG>ATG	p.T71M	SLIT2_uc003gps.1_Missense_Mutation_p.T71M	NM_004787	NP_004778	O94813	SLIT2_HUMAN	slit homolog 2 precursor	71	LRR 1.				apoptosis involved in luteolysis|axon extension involved in axon guidance|branching morphogenesis of a tube|cell migration involved in sprouting angiogenesis|cellular response to heparin|cellular response to hormone stimulus|chemorepulsion involved in postnatal olfactory bulb interneuron migration|corticospinal neuron axon guidance through spinal cord|induction of negative chemotaxis|motor axon guidance|negative regulation of actin filament polymerization|negative regulation of cell growth|negative regulation of cellular response to growth factor stimulus|negative regulation of chemokine-mediated signaling pathway|negative regulation of endothelial cell migration|negative regulation of lamellipodium assembly|negative regulation of mononuclear cell migration|negative regulation of neutrophil chemotaxis|negative regulation of protein phosphorylation|negative regulation of retinal ganglion cell axon guidance|negative regulation of small GTPase mediated signal transduction|negative regulation of smooth muscle cell chemotaxis|negative regulation of vascular permeability|positive regulation of apoptosis|positive regulation of axonogenesis|response to cortisol stimulus|retinal ganglion cell axon guidance|Roundabout signaling pathway|ureteric bud development	cell surface|cytoplasm|extracellular space|plasma membrane	calcium ion binding|GTPase inhibitor activity|heparin binding|laminin-1 binding|protein homodimerization activity|proteoglycan binding|Roundabout binding			central_nervous_system(4)|skin(4)|ovary(3)	11						ACAAGAATTACGAAGACAGAT	0.294		NA											14	28					0	0	0	0
PCDH7	5099	broad.mit.edu	37	4	30726069	30726069	+	Missense_Mutation	SNP	C	C	T			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr4:30726069C>T	uc003gsk.1	+	1	4033	c.3025C>T	c.(3025-3027)CCC>TCC	p.P1009S	PCDH7_uc011bxw.1_Missense_Mutation_p.P962S|PCDH7_uc011bxx.1_Missense_Mutation_p.P1009S	NM_002589	NP_002580	O60245	PCDH7_HUMAN	protocadherin 7 isoform a precursor	1009	Cytoplasmic (Potential).				homophilic cell adhesion	integral to plasma membrane	calcium ion binding			upper_aerodigestive_tract(1)|ovary(1)|liver(1)|skin(1)	4						TCAGCTTCATCCCCAGTCACC	0.507		NA											13	29					0	0	0	0
GYPA	2993	broad.mit.edu	37	4	145035857	145035857	+	Missense_Mutation	SNP	C	C	T			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr4:145035857C>T	uc003ijo.3	-	6	537	c.421G>A	c.(421-423)GAA>AAA	p.E141K	GYPA_uc003ijn.2_Intron|GYPA_uc011cia.1_RNA|GYPA_uc011cib.1_Missense_Mutation_p.E108K|GYPA_uc003ijp.3_Missense_Mutation_p.E109K|GYPA_uc010ioq.2_Missense_Mutation_p.E128K|GYPA_uc010ior.2_Missense_Mutation_p.E76K|GYPA_uc010ios.1_RNA	NM_002099	NP_002090	P02724	GLPA_HUMAN	glycophorin A precursor	141	Cytoplasmic.				interspecies interaction between organisms	membrane fraction	receptor activity			central_nervous_system(2)	2	all_hematologic(180;0.15)					TTTTCTATTTCAACAGAACTT	0.353		NA											11	26					0	0	0	0
TLL1	7092	broad.mit.edu	37	4	166929097	166929097	+	Missense_Mutation	SNP	C	C	G			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr4:166929097C>G	uc003irh.1	+	7	1461	c.814C>G	c.(814-816)CAA>GAA	p.Q272E	TLL1_uc011cjn.1_Missense_Mutation_p.Q272E|TLL1_uc011cjo.1_Missense_Mutation_p.Q96E	NM_012464	NP_036596	O43897	TLL1_HUMAN	tolloid-like 1 precursor	272	Metalloprotease (By similarity).				cell differentiation|proteolysis|skeletal system development	extracellular region	calcium ion binding|metalloendopeptidase activity|zinc ion binding			skin(3)|ovary(2)|breast(1)|central_nervous_system(1)	7	all_hematologic(180;0.221)	Melanoma(52;0.0315)|Prostate(90;0.0405)		GBM - Glioblastoma multiforme(119;0.103)		GTTCTTAGGTCAAGAGTACAA	0.408		NA											17	39					0	0	0	0
FAM149A	25854	broad.mit.edu	37	4	187086549	187086549	+	Missense_Mutation	SNP	C	C	A	rs34360147		TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr4:187086549C>A	uc003iyt.3	+	11	1674	c.1095C>A	c.(1093-1095)AGC>AGA	p.S365R	FAM149A_uc011cla.1_Missense_Mutation_p.S365R|FAM149A_uc003iyu.3_Missense_Mutation_p.S365R|FAM149A_uc010isl.2_Missense_Mutation_p.S365R|FAM149A_uc011clb.1_Missense_Mutation_p.S365R	NM_015398	NP_056213	A5PLN7	F149A_HUMAN	hypothetical protein LOC25854	656										breast(1)	1		all_cancers(14;4.27e-52)|all_epithelial(14;7.69e-39)|all_lung(41;1.34e-13)|Lung NSC(41;3.58e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.0066)|Hepatocellular(41;0.00886)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|all_neural(102;0.243)		OV - Ovarian serous cystadenocarcinoma(60;1.19e-10)|BRCA - Breast invasive adenocarcinoma(30;1.22e-05)|GBM - Glioblastoma multiforme(59;0.000122)|STAD - Stomach adenocarcinoma(60;0.000288)|LUSC - Lung squamous cell carcinoma(40;0.00241)|READ - Rectum adenocarcinoma(43;0.166)		CGTCACGGAGCAGGTTCCCCC	0.542		NA											10	33					6.4e-05	6.82e-05	1	0
ADCY2	108	broad.mit.edu	37	5	7773108	7773108	+	Missense_Mutation	SNP	G	G	C			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr5:7773108G>C	uc003jdz.1	+	18	2345	c.2278G>C	c.(2278-2280)GAG>CAG	p.E760Q	ADCY2_uc011cmo.1_Missense_Mutation_p.E580Q	NM_020546	NP_065433	Q08462	ADCY2_HUMAN	adenylate cyclase 2	760					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	cytoplasm|dendrite|integral to membrane|plasma membrane	ATP binding|metal ion binding			ovary(5)|pancreas(1)|skin(1)	7						GGTAAACTATGAGCTGAAGAT	0.502		NA											30	75					0	0	0	0
GPBP1	65056	broad.mit.edu	37	5	56546873	56546873	+	Missense_Mutation	SNP	G	G	C			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr5:56546873G>C	uc003jrh.3	+	10	2339	c.1065G>C	c.(1063-1065)GAG>GAC	p.E355D	GPBP1_uc010iwg.2_Missense_Mutation_p.E375D|GPBP1_uc003jri.3_Missense_Mutation_p.E184D|GPBP1_uc003jrj.3_Missense_Mutation_p.E347D|GPBP1_uc003jrk.3_Missense_Mutation_p.E362D|GPBP1_uc003jrl.3_RNA	NM_022913	NP_075064	Q86WP2	GPBP1_HUMAN	GC-rich promoter binding protein 1 isoform 1	355					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding			large_intestine(1)|central_nervous_system(1)	2		Lung NSC(810;0.000861)|Prostate(74;0.0305)|Breast(144;0.222)		OV - Ovarian serous cystadenocarcinoma(10;7.64e-39)		TTCCTCAAGAGAATGGCAATG	0.398		NA											12	38					0	0	0	0
CTNNA1	1495	broad.mit.edu	37	5	138260216	138260216	+	Missense_Mutation	SNP	G	G	C			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr5:138260216G>C	uc003ldh.2	+	12	1659	c.1564G>C	c.(1564-1566)GAT>CAT	p.D522H	CTNNA1_uc011cyx.1_Missense_Mutation_p.D419H|CTNNA1_uc011cyy.1_Missense_Mutation_p.D399H|CTNNA1_uc003ldi.2_Missense_Mutation_p.D220H|CTNNA1_uc003ldj.2_Missense_Mutation_p.D522H|CTNNA1_uc003ldl.2_Missense_Mutation_p.D152H	NM_001903	NP_001894	P35221	CTNA1_HUMAN	catenin, alpha 1	522					adherens junction organization|apical junction assembly|cell adhesion|cellular response to indole-3-methanol|muscle cell differentiation|positive regulation of muscle cell differentiation	actin cytoskeleton|catenin complex|cytosol	beta-catenin binding|cadherin binding|gamma-catenin binding|structural molecule activity|vinculin binding			breast(6)|ovary(2)|large_intestine(2)|kidney(1)	11			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00325)			CATTTTGGAAGATGTGAACAA	0.463		NA											5	17					0	0	0	0
SLC36A2	153201	broad.mit.edu	37	5	150723750	150723750	+	Silent	SNP	G	G	A			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr5:150723750G>A	uc003lty.2	-	2	373	c.243C>T	c.(241-243)AAC>AAT	p.N81N	GM2A_uc011dcs.1_Intron|SLC36A2_uc003ltz.2_RNA|SLC36A2_uc003lua.2_Translation_Start_Site|SLC36A2_uc010jhv.2_Silent_p.N81N|SLC36A2_uc011dct.1_Silent_p.N81N	NM_181776	NP_861441	Q495M3	S36A2_HUMAN	solute carrier family 36, member 2	81	Extracellular (Potential).				cellular nitrogen compound metabolic process	cytoplasm|integral to membrane|plasma membrane	glycine transmembrane transporter activity			ovary(1)|central_nervous_system(1)	2		Medulloblastoma(196;0.109)|all_hematologic(541;0.243)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			GGATGCCCGCGTTCTTCACAG	0.547		NA											5	17					0	0	0	0
TRIM27	5987	broad.mit.edu	37	6	28871933	28871933	+	Missense_Mutation	SNP	G	G	A			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr6:28871933G>A	uc003nlr.2	-	8	1815	c.1456C>T	c.(1456-1458)CCT>TCT	p.P486S	TRIM27_uc003nls.2_3'UTR|TRIM27_uc003nlt.1_3'UTR	NM_006510	NP_006501	P14373	TRI27_HUMAN	ret finger protein	486	B30.2/SPRY.				cell proliferation|negative regulation of gene expression, epigenetic|negative regulation of transcription from RNA polymerase II promoter|protein trimerization|spermatogenesis|transcription, DNA-dependent	cytoplasm|integral to plasma membrane|membrane fraction|nuclear membrane|PML body	DNA binding|protein binding|transmembrane receptor protein tyrosine kinase activity|zinc ion binding			ovary(1)	1						ATGATCAGAGGAGCTGCACTT	0.522		NA	T	RET	papillary thyroid								22	69					0	0	0	0
TRERF1	55809	broad.mit.edu	37	6	42224469	42224469	+	Silent	SNP	C	C	T			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr6:42224469C>T	uc003osd.2	-	12	3140	c.2577G>A	c.(2575-2577)GTG>GTA	p.V859V	TRERF1_uc011duq.1_Silent_p.V776V|TRERF1_uc003osb.2_Silent_p.V615V|TRERF1_uc003osc.2_Silent_p.V615V|TRERF1_uc003ose.2_Silent_p.V879V	NM_033502	NP_277037	Q96PN7	TREF1_HUMAN	transcriptional regulating factor 1	859	ELM2.|Interacts with CREBBP.				cholesterol catabolic process|homeostatic process|multicellular organismal development|positive regulation of transcription, DNA-dependent|regulation of hormone biosynthetic process|steroid biosynthetic process	nucleus	DNA bending activity|ligand-dependent nuclear receptor transcription coactivator activity|RNA polymerase II transcription cofactor activity|sequence-specific DNA binding transcription factor activity|transcription factor binding|zinc ion binding			ovary(3)|pancreas(1)|skin(1)	5	Colorectal(47;0.196)		Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)			TCCTTACCATCACATCACCTT	0.403		NA											14	37					0	0	0	0
RIMS1	22999	broad.mit.edu	37	6	72889449	72889449	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr6:72889449C>T	uc003pga.2	+	5	720	c.643C>T	c.(643-645)CGA>TGA	p.R215*	RIMS1_uc011dyb.1_5'Flank|RIMS1_uc003pgc.2_5'Flank|RIMS1_uc003pgb.3_5'Flank	NM_014989	NP_055804	Q86UR5	RIMS1_HUMAN	regulating synaptic membrane exocytosis 1	215					calcium ion-dependent exocytosis|cellular membrane fusion|glutamate secretion|intracellular protein transport|protein complex assembly|regulated secretory pathway|response to stimulus|synaptic vesicle exocytosis|visual perception	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			ovary(7)|pancreas(2)|breast(1)	10		all_epithelial(107;0.179)|all_hematologic(105;0.212)				ACTCCAAGAGCGATCGCGGTC	0.587		NA											12	40					0	0	0	0
BEND3	57673	broad.mit.edu	37	6	107390676	107390676	+	Silent	SNP	G	G	A			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr6:107390676G>A	uc003prs.2	-	5	2369	c.1719C>T	c.(1717-1719)TTC>TTT	p.F573F		NM_001080450	NP_001073919	Q5T5X7	BEND3_HUMAN	BEN domain containing 3	573	BEN 3.									ovary(3)	3						GGCGCGAGGCGAAGTTGCCGA	0.637		NA											27	40					0	0	0	0
MAP7	9053	broad.mit.edu	37	6	136687111	136687111	+	Silent	SNP	C	C	T	rs143331676	byFrequency	TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr6:136687111C>T	uc003qgz.2	-	10	1281	c.1035G>A	c.(1033-1035)CCG>CCA	p.P345P	MAP7_uc011edf.1_Silent_p.P330P|MAP7_uc011edg.1_Silent_p.P375P|MAP7_uc010kgu.2_Silent_p.P367P|MAP7_uc011edh.1_Silent_p.P330P|MAP7_uc010kgv.2_Silent_p.P367P|MAP7_uc010kgs.2_Silent_p.P199P|MAP7_uc011edi.1_Silent_p.P199P|MAP7_uc010kgq.1_Silent_p.P251P|MAP7_uc003qha.1_Silent_p.P308P|MAP7_uc010kgr.2_Silent_p.P199P	NM_003980	NP_003971	Q14244	MAP7_HUMAN	microtubule-associated protein 7	345	Pro-rich.				establishment or maintenance of cell polarity|microtubule cytoskeleton organization|protein localization in plasma membrane|response to osmotic stress	basolateral plasma membrane|microtubule|microtubule associated complex|nucleus|perinuclear region of cytoplasm	receptor binding|structural molecule activity				0	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00199)|OV - Ovarian serous cystadenocarcinoma(155;0.00643)		AGGAGGATGTCGGTCTGGGTG	0.592		NA											15	42					0	0	0	0
HBP1	26959	broad.mit.edu	37	7	106826299	106826299	+	Missense_Mutation	SNP	G	G	A	rs151293151	by1000genomes	TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr7:106826299G>A	uc003vdy.2	+	4	638	c.452G>A	c.(451-453)CGC>CAC	p.R151H	HBP1_uc011klv.1_Missense_Mutation_p.R161H|HBP1_uc003vdz.2_Missense_Mutation_p.R151H|HBP1_uc003vea.2_Missense_Mutation_p.R151H|HBP1_uc003veb.1_Missense_Mutation_p.R151H	NM_012257	NP_036389	O60381	HBP1_HUMAN	HMG-box transcription factor 1	151					cell cycle arrest|regulation of transcription, DNA-dependent|transcription, DNA-dependent|Wnt receptor signaling pathway	nucleus	DNA binding			skin(1)	1						TCCTATGCACGCCCTCCACCA	0.423		NA											39	61					0	0	0	0
NOS3	4846	broad.mit.edu	37	7	150695737	150695737	+	Missense_Mutation	SNP	G	G	A			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr7:150695737G>A	uc003wif.2	+	7	1081	c.785G>A	c.(784-786)CGG>CAG	p.R262Q	NOS3_uc011kuy.1_Missense_Mutation_p.R56Q|NOS3_uc011kuz.1_Missense_Mutation_p.R262Q|NOS3_uc011kva.1_Missense_Mutation_p.R262Q|NOS3_uc011kvb.1_Missense_Mutation_p.R262Q	NM_000603	NP_000594	P29474	NOS3_HUMAN	nitric oxide synthase 3 isoform 1	262	Interaction with NOSIP.				anti-apoptosis|arginine catabolic process|blood vessel remodeling|endothelial cell migration|mitochondrion organization|negative regulation of muscle hyperplasia|negative regulation of platelet activation|nitric oxide biosynthetic process|platelet activation|positive regulation of angiogenesis|positive regulation of guanylate cyclase activity|positive regulation of vasodilation|regulation of blood vessel size|regulation of nitric-oxide synthase activity|regulation of systemic arterial blood pressure by endothelin|response to fluid shear stress|response to heat|smooth muscle hyperplasia	caveola|cytoskeleton|cytosol|Golgi membrane	actin monomer binding|arginine binding|cadmium ion binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|tetrahydrobiopterin binding			central_nervous_system(5)|large_intestine(2)|skin(1)	8	all_neural(206;0.219)		OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)	L-Arginine(DB00125)|L-Citrulline(DB00155)|Rosuvastatin(DB01098)|Tetrahydrobiopterin(DB00360)	GGCTCTGTGCGGGGGGACCCA	0.652		NA											3	8					0	0	0	0
SHH	6469	broad.mit.edu	37	7	155599120	155599120	+	Silent	SNP	G	G	A			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr7:155599120G>A	uc003wmk.1	-	2	583	c.432C>T	c.(430-432)CGC>CGT	p.R144R	SHH_uc003wmh.1_RNA|SHH_uc003wmi.1_Silent_p.R57R|SHH_uc003wmj.1_Silent_p.R57R	NM_000193	NP_000184	Q15465	SHH_HUMAN	sonic hedgehog preproprotein	144			R -> P (in HPE3).		androgen metabolic process|axon guidance|branching involved in ureteric bud morphogenesis|CD4-positive or CD8-positive, alpha-beta T cell lineage commitment|embryonic digit morphogenesis|hindbrain development|intein-mediated protein splicing|lymphoid progenitor cell differentiation|metanephric mesenchymal cell proliferation involved in metanephros development|midbrain development|negative regulation of cell migration|negative regulation of kidney smooth muscle cell differentiation|negative regulation of ureter smooth muscle cell differentiation|negative thymic T cell selection|neural crest cell migration|neuroblast proliferation|patterning of blood vessels|positive regulation of alpha-beta T cell differentiation|positive regulation of immature T cell proliferation in thymus|positive regulation of kidney smooth muscle cell differentiation|positive regulation of mesenchymal cell proliferation involved in ureter development|positive regulation of T cell differentiation in thymus|positive regulation of ureter smooth muscle cell differentiation|positive thymic T cell selection|proteolysis|sclerotome development|stem cell development|thymus development|vasculogenesis|ventral midline development	cell surface|extracellular space|membrane raft|plasma membrane	calcium ion binding|laminin-1 binding|peptidase activity|signal transducer activity|zinc ion binding			central_nervous_system(3)|lung(1)	4	all_neural(206;0.101)	all_hematologic(28;0.0592)	OV - Ovarian serous cystadenocarcinoma(82;0.00882)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		TGTCCACTGCGCGGCCCTCGT	0.642		NA											13	18					0	0	0	0
TNKS	8658	broad.mit.edu	37	8	9564372	9564372	+	Missense_Mutation	SNP	G	G	A			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr8:9564372G>A	uc003wss.2	+	8	1326	c.1321G>A	c.(1321-1323)GAG>AAG	p.E441K	TNKS_uc011kwv.1_Missense_Mutation_p.E441K|TNKS_uc011kww.1_Missense_Mutation_p.E204K	NM_003747	NP_003738	O95271	TNKS1_HUMAN	tankyrase, TRF1-interacting ankyrin-related	441	ANK 6.				mitotic spindle organization|mRNA transport|negative regulation of DNA binding|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of telomere maintenance via telomerase|protein auto-ADP-ribosylation|protein localization to chromosome, telomeric region|protein poly-ADP-ribosylation|protein polyubiquitination|protein transport|spindle assembly|transmembrane transport|Wnt receptor signaling pathway	chromosome, centromeric region|Golgi membrane|microsome|nuclear chromosome, telomeric region|nuclear membrane|nuclear pore|pericentriolar material	NAD+ ADP-ribosyltransferase activity|protein binding|zinc ion binding			lung(4)|ovary(2)|kidney(1)	7				COAD - Colon adenocarcinoma(149;0.0467)		TCCACTGCACGAGGCTGCTTC	0.438		NA											20	66					0	0	0	0
DPYS	1807	broad.mit.edu	37	8	105393527	105393527	+	Missense_Mutation	SNP	G	G	C			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr8:105393527G>C	uc003yly.3	-	9	1588	c.1459C>G	c.(1459-1461)CCT>GCT	p.P487A	DPYS_uc010mcf.1_Missense_Mutation_p.P57A	NM_001385	NP_001376	Q14117	DPYS_HUMAN	dihydropyrimidinase	487					protein homotetramerization|pyrimidine nucleoside catabolic process|thymine catabolic process|uracil catabolic process	cytosol	dihydropyrimidinase activity|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)	2			OV - Ovarian serous cystadenocarcinoma(57;1.61e-06)|STAD - Stomach adenocarcinoma(118;0.229)			CGCTCCACAGGGGTAGGTGTG	0.473		NA											13	53					0	0	0	0
EXT1	2131	broad.mit.edu	37	8	119123160	119123160	+	Silent	SNP	A	A	T			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr8:119123160A>T	uc003yok.1	-	1	899	c.126T>A	c.(124-126)GGT>GGA	p.G42G		NM_000127	NP_000118	Q16394	EXT1_HUMAN	exostosin 1	42	Lumenal (Potential).				glycosaminoglycan biosynthetic process|heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process|ossification|signal transduction|skeletal system development	Golgi membrane|integral to endoplasmic reticulum membrane	glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity|heparan sulfate N-acetylglucosaminyltransferase activity|N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity|protein heterodimerization activity|protein homodimerization activity			ovary(2)|lung(2)	4	all_cancers(13;2.36e-26)|Lung NSC(37;5.02e-07)|Ovarian(258;0.0173)		STAD - Stomach adenocarcinoma(47;0.012)			AGCCATTCCTACCGCTGTGTT	0.562		NA	Mis|N|F|S			exostoses|osteosarcoma			Hereditary_Multiple_Exostoses|Langer-Giedion_syndrome				7	30					0	0	0	0
FAM135B	51059	broad.mit.edu	37	8	139268962	139268962	+	Missense_Mutation	SNP	A	A	G			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr8:139268962A>G	uc003yuy.2	-	5	509	c.338T>C	c.(337-339)GTG>GCG	p.V113A	FAM135B_uc003yux.2_Missense_Mutation_p.V14A|FAM135B_uc003yuz.2_RNA	NM_015912	NP_056996	Q49AJ0	F135B_HUMAN	hypothetical protein LOC51059	113										ovary(7)|skin(2)	9	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			GTGCAGATCCACCTTGAGTTG	0.438		NA								HNSCC(54;0.14)			3	25					0	0	0	0
TRAPPC9	83696	broad.mit.edu	37	8	141370156	141370156	+	Silent	SNP	C	C	G			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr8:141370156C>G	uc003yvj.2	-	9	1622	c.1488G>C	c.(1486-1488)TCG>TCC	p.S496S	TRAPPC9_uc003yvh.2_Silent_p.S594S|TRAPPC9_uc003yvi.1_Silent_p.S487S	NM_001160372	NP_001153844	Q96Q05	TPPC9_HUMAN	trafficking protein particle complex 9 isoform	496					cell differentiation	endoplasmic reticulum|Golgi apparatus				skin(2)	2						CACCCTGATCCGACAAGAAGT	0.498		NA											18	64					0	0	0	0
PLEC	5339	broad.mit.edu	37	8	144992793	144992793	+	Silent	SNP	G	G	A			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr8:144992793G>A	uc003zaf.1	-	32	11777	c.11607C>T	c.(11605-11607)TTC>TTT	p.F3869F	PLEC_uc003zab.1_Silent_p.F3732F|PLEC_uc003zac.1_Silent_p.F3736F|PLEC_uc003zad.2_Silent_p.F3732F|PLEC_uc003zae.1_Silent_p.F3700F|PLEC_uc003zag.1_Silent_p.F3710F|PLEC_uc003zah.2_Silent_p.F3718F|PLEC_uc003zaj.2_Silent_p.F3759F	NM_201380	NP_958782	Q15149	PLEC_HUMAN	plectin isoform 1	3869	Globular 2.|Plectin 18.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle|structural constituent of muscle			large_intestine(2)|ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	9						GGTCCAGCAGGAAGCCTGTGG	0.672		NA											10	33					0	0	0	0
TLN1	7094	broad.mit.edu	37	9	35720835	35720835	+	Missense_Mutation	SNP	C	C	T			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr9:35720835C>T	uc003zxt.2	-	11	1534	c.1180G>A	c.(1180-1182)GGC>AGC	p.G394S		NM_006289	NP_006280	Q9Y490	TLN1_HUMAN	talin 1	394	FERM.|Interaction with LAYN (By similarity).				axon guidance|cell adhesion|cell-cell junction assembly|cellular component movement|cytoskeletal anchoring at plasma membrane|muscle contraction|platelet activation|platelet degranulation	actin cytoskeleton|centrosome|cytosol|extracellular region|focal adhesion|intracellular membrane-bounded organelle|ruffle membrane	actin binding|insulin receptor binding|LIM domain binding|structural constituent of cytoskeleton|vinculin binding			lung(7)|breast(3)|ovary(2)|central_nervous_system(1)	13	all_epithelial(49;0.167)		Lung(28;0.00276)|LUSC - Lung squamous cell carcinoma(32;0.00418)|STAD - Stomach adenocarcinoma(86;0.194)			TCGATGTAGCCGGCAATGAGC	0.512		NA											9	95					0	0	0	0
FLJ46321	389763	broad.mit.edu	37	9	84605930	84605930	+	Missense_Mutation	SNP	A	A	T			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr9:84605930A>T	uc004amn.2	+	4	592	c.545A>T	c.(544-546)GAA>GTA	p.E182V		NM_001001670	NP_001001670	Q6ZQQ2	F75D1_HUMAN	hypothetical protein LOC389763	182	Pro-rich.					integral to membrane					0						ACCCCTCCAGAAGACCTAATA	0.547		NA											20	59					0	0	0	0
FBP1	2203	broad.mit.edu	37	9	97369181	97369181	+	Silent	SNP	A	A	G			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr9:97369181A>G	uc004auw.3	-	5	952	c.621T>C	c.(619-621)GGT>GGC	p.G207G	FBP1_uc010mrl.2_Silent_p.G207G	NM_000507	NP_000498	P09467	F16P1_HUMAN	fructose-1,6-bisphosphatase 1	207					gluconeogenesis	cytosol	fructose 1,6-bisphosphate 1-phosphatase activity|fructose-2,6-bisphosphate 2-phosphatase activity|identical protein binding|metal ion binding				0		Acute lymphoblastic leukemia(62;0.136)			Adenosine monophosphate(DB00131)	TGTAGATTTTACCTTTCTTTT	0.512		NA											39	45					0	0	0	0
KIAA1529	57653	broad.mit.edu	37	9	100071844	100071844	+	Missense_Mutation	SNP	G	G	A			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr9:100071844G>A	uc011lut.1	+	15	1540	c.767G>A	c.(766-768)AGC>AAC	p.S256N	KIAA1529_uc004axe.1_Missense_Mutation_p.S256N|KIAA1529_uc004axg.1_Missense_Mutation_p.S117N|KIAA1529_uc011lus.1_Missense_Mutation_p.S117N|KIAA1529_uc010msm.1_RNA|KIAA1529_uc004axf.2_Missense_Mutation_p.S117N|KIAA1529_uc011luv.1_Missense_Mutation_p.S117N	NM_020893	NP_065944			hypothetical protein LOC57653									p.S256R(1)		ovary(4)|large_intestine(2)|skin(1)	7		Acute lymphoblastic leukemia(62;0.154)				TGGATGCACAGCCTCCCCAAC	0.547		NA											13	38					0	0	0	0
ZBTB43	23099	broad.mit.edu	37	9	129596134	129596134	+	Missense_Mutation	SNP	C	C	T			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr9:129596134C>T	uc004bql.2	+	3	1619	c.1346C>T	c.(1345-1347)TCT>TTT	p.S449F	ZBTB43_uc010mxf.2_Missense_Mutation_p.S449F	NM_014007	NP_054726	O43298	ZBT43_HUMAN	zinc finger and BTB domain containing 43	449	C2H2-type 3; atypical.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						CATGTGACTTCTTGTACTAAG	0.443		NA											37	127					0	0	0	0
PMPCA	23203	broad.mit.edu	37	9	139311437	139311437	+	Missense_Mutation	SNP	G	G	A			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr9:139311437G>A	uc004chl.2	+	7	673	c.668G>A	c.(667-669)CGT>CAT	p.R223H	PMPCA_uc010nbl.2_Missense_Mutation_p.R123H|PMPCA_uc011mdz.1_Missense_Mutation_p.R92H|PMPCA_uc004chm.1_5'UTR|PMPCA_uc004chn.1_5'Flank	NM_015160	NP_055975	Q10713	MPPA_HUMAN	peptidase (mitochondrial processing) alpha	223					proteolysis	mitochondrial inner membrane|mitochondrial matrix	metalloendopeptidase activity|zinc ion binding				0		Myeloproliferative disorder(178;0.0821)		OV - Ovarian serous cystadenocarcinoma(145;9.3e-06)|Epithelial(140;1.15e-05)		GGCCTCCACCGTTTCTGCCCC	0.562		NA											7	32					0	0	0	0
ABCA2	20	broad.mit.edu	37	9	139912245	139912245	+	Silent	SNP	G	G	C			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr9:139912245G>C	uc011mem.1	-	15	2350	c.2202C>G	c.(2200-2202)CTC>CTG	p.L734L	ABCA2_uc011mel.1_Silent_p.L735L|ABCA2_uc004ckl.1_Silent_p.L665L|ABCA2_uc004ckm.1_Silent_p.L765L|ABCA2_uc004ckn.1_RNA	NM_001606	NP_001597	Q9BZC7	ABCA2_HUMAN	ATP-binding cassette, sub-family A, member 2	734					cholesterol homeostasis|lipid metabolic process|regulation of intracellular cholesterol transport|regulation of transcription from RNA polymerase II promoter|response to drug|response to steroid hormone stimulus	ATP-binding cassette (ABC) transporter complex|cytoplasmic membrane-bounded vesicle|endosome|integral to membrane|microtubule organizing center	ATP binding|ATPase activity, coupled to transmembrane movement of substances				0	all_cancers(76;0.16)	Myeloproliferative disorder(178;0.0511)	STAD - Stomach adenocarcinoma(284;0.123)	OV - Ovarian serous cystadenocarcinoma(145;2.94e-05)|Epithelial(140;0.00048)		GCACCTCCTTGAGCCGGTGCT	0.692		NA											5	15					0	0	0	0
FAM47C	442444	broad.mit.edu	37	X	37026576	37026576	+	Silent	SNP	G	G	A			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chrX:37026576G>A	uc004ddl.1	+	1	107	c.93G>A	c.(91-93)GCG>GCA	p.A31A		NM_001013736	NP_001013758	Q5HY64	FA47C_HUMAN	hypothetical protein LOC442444	31										ovary(3)	3						AGTACTTCGCGAAGCGCAAGC	0.642		NA											12	10					0	0	0	0
SPANXN5	494197	broad.mit.edu	37	X	52825613	52825613	+	Missense_Mutation	SNP	G	G	C			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chrX:52825613G>C	uc004drc.1	-	2	134	c.134C>G	c.(133-135)ACA>AGA	p.T45R		NM_001009616	NP_001009616	Q5MJ07	SPXN5_HUMAN	SPANX family, member N5	45											0	Ovarian(276;0.236)					ATATTCTGATGTTTTCATCTT	0.393		NA											3	47					0	0	0	0
HUWE1	10075	broad.mit.edu	37	X	53563194	53563194	+	Missense_Mutation	SNP	C	C	T			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chrX:53563194C>T	uc004dsp.2	-	80	12847	c.12445G>A	c.(12445-12447)GAA>AAA	p.E4149K	HUWE1_uc004dsn.2_Missense_Mutation_p.E2957K	NM_031407	NP_113584	Q7Z6Z7	HUWE1_HUMAN	HECT, UBA and WWE domain containing 1	4149	HECT.				base-excision repair|cell differentiation|histone ubiquitination|protein monoubiquitination|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	DNA binding|protein binding|ubiquitin-protein ligase activity			ovary(8)|large_intestine(4)|breast(4)|kidney(1)	17						TGGTAATCTTCACTCTCCATA	0.448		NA											11	22					0	0	0	0
CHM	1121	broad.mit.edu	37	X	85302517	85302517	+	Missense_Mutation	SNP	G	G	A			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chrX:85302517G>A	uc004eet.2	-	1	50	c.20C>T	c.(19-21)TCG>TTG	p.S7L	CHM_uc011mqz.1_5'UTR|CHM_uc004eeu.3_5'Flank|CHM_uc004eev.3_Missense_Mutation_p.S7L	NM_000390	NP_000381	P24386	RAE1_HUMAN	choroideremia isoform a	7					intracellular protein transport|protein geranylgeranylation|response to stimulus|visual perception	Rab-protein geranylgeranyltransferase complex	GTPase activator activity|Rab geranylgeranyltransferase activity			ovary(1)	1		all_lung(315;5.41e-06)				ATCAAACTCCGAAGGGAGAGT	0.468		NA											7	4					0	0	0	0
IGSF1	3547	broad.mit.edu	37	X	130416550	130416550	+	Missense_Mutation	SNP	C	C	T			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chrX:130416550C>T	uc004ewd.2	-	7	1352	c.1114G>A	c.(1114-1116)GAT>AAT	p.D372N	IGSF1_uc004ewe.3_Missense_Mutation_p.D361N|IGSF1_uc004ewf.2_Missense_Mutation_p.D352N	NM_001555	NP_001546	Q8N6C5	IGSF1_HUMAN	immunoglobulin superfamily, member 1 isoform 1	372	Ig-like C2-type 4.|Extracellular (Potential).				regulation of transcription, DNA-dependent	extracellular region|integral to membrane	inhibin beta-A binding|inhibin beta-B binding			ovary(3)|lung(1)|central_nervous_system(1)	5						GTGTTGTCATCGATGCTGGTG	0.468		NA											38	28					0	0	0	0
ATP2B3	492	broad.mit.edu	37	X	152813447	152813447	+	Silent	SNP	C	C	T			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chrX:152813447C>T	uc004fht.1	+	7	1239	c.1113C>T	c.(1111-1113)ATC>ATT	p.I371I	ATP2B3_uc004fhs.1_Silent_p.I371I	NM_001001344	NP_001001344	Q16720	AT2B3_HUMAN	plasma membrane calcium ATPase 3 isoform 3b	371	Helical; (Potential).				ATP biosynthetic process|platelet activation	integral to membrane|plasma membrane	ATP binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding			pancreas(1)	1	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					CCGTGCAGATCGGGAAAGCAG	0.597		NA											12	22					0	0	0	0
ATP8B4	79895	broad.mit.edu	37	15	50190329	50190329	+	Frame_Shift_Del	DEL	C	C	-			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr15:50190329delC	uc001zxu.2	-	22	2551	c.2409delG	c.(2407-2409)AAGfs	p.K803fs	ATP8B4_uc010ber.2_Frame_Shift_Del_p.K676fs|ATP8B4_uc010ufd.1_Frame_Shift_Del_p.K613fs|ATP8B4_uc010ufe.1_RNA|ATP8B4_uc001zxv.1_Frame_Shift_Del_p.K101fs	NM_024837	NP_079113	Q8TF62	AT8B4_HUMAN	ATPase class I type 8B member 4	803	Cytoplasmic (Potential).				ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			skin(3)|ovary(2)|breast(2)|large_intestine(1)	8		all_lung(180;0.00183)		all cancers(107;2.41e-07)|GBM - Glioblastoma multiforme(94;8.28e-05)		TTCTGTACTTCTTCACCAGCT	0.433		NA											31	50	---	---	---	---	NA	NA	NA	NA
C17orf104	284071	broad.mit.edu	37	17	42746783	42746783	+	Frame_Shift_Del	DEL	A	A	-			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr17:42746783delA	uc010czv.2	+	6	2355	c.2355delA	c.(2353-2355)GGAfs	p.G785fs	C17orf104_uc002igz.3_Frame_Shift_Del_p.G619fs|C17orf104_uc010wja.1_RNA|C17orf104_uc002iha.2_Frame_Shift_Del_p.G619fs	NM_001145080	NP_001138552	A2RUB1	CQ104_HUMAN	hypothetical protein LOC284071	785										central_nervous_system(1)	1						ATTATCCTGGAAAAAAAGTAT	0.353		NA											2	4	---	---	---	---	NA	NA	NA	NA
ZNF43	7594	broad.mit.edu	37	19	21992490	21992491	+	Frame_Shift_Ins	INS	-	-	T			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr19:21992490_21992491insT	uc002nqj.2	-	4	478_479	c.348_349insA	c.(346-351)AAAGACfs	p.K116fs	ZNF43_uc010ecv.2_Frame_Shift_Ins_p.K110fs|ZNF43_uc002nql.2_Frame_Shift_Ins_p.K110fs|ZNF43_uc002nqm.2_Frame_Shift_Ins_p.K110fs|ZNF43_uc002nqk.2_Frame_Shift_Ins_p.K46fs	NM_003423	NP_003414	P17038	ZNF43_HUMAN	zinc finger protein 43	116_117					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)|ovary(1)	2		Renal(1328;0.000219)|Hepatocellular(1079;0.121)		GBM - Glioblastoma multiforme(1328;5.97e-05)|STAD - Stomach adenocarcinoma(1328;0.0127)		CTTTTATGGTCTTTTTTTAAAT	0.351		NA											18	55	---	---	---	---	NA	NA	NA	NA
GTF2IRD2	84163	broad.mit.edu	37	7	74239555	74239556	+	In_Frame_Ins	INS	-	-	TAC			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr7:74239555_74239556insTAC	uc003ubd.1	-	4	448_449	c.264_265insGTA	c.(262-267)insGTA	p.88_89insV	GTF2IRD2_uc011kfi.1_In_Frame_Ins_p.88_89insV|GTF2IRD2_uc003ubf.1_In_Frame_Ins_p.88_89insV|GTF2IRD2_uc003ubg.1_In_Frame_Ins_p.88_89insV	NM_173537	NP_775808	Q86UP8	GTD2A_HUMAN	GTF2I repeat domain containing 2	88_89					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						CAGGGAGGTTTCACCTCACACA	0.485		NA											7	33	---	---	---	---	NA	NA	NA	NA
SLC26A7	115111	broad.mit.edu	37	8	92350418	92350418	+	Frame_Shift_Del	DEL	A	A	-			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr8:92350418delA	uc003yex.2	+	8	1114	c.836delA	c.(835-837)GAAfs	p.E279fs	SLC26A7_uc003yey.2_Intron|SLC26A7_uc003yez.2_Frame_Shift_Del_p.E279fs|SLC26A7_uc003yfa.2_Frame_Shift_Del_p.E279fs	NM_052832	NP_439897	Q8TE54	S26A7_HUMAN	solute carrier family 26, member 7 isoform a	279	Cytoplasmic (Potential).					basolateral plasma membrane|integral to membrane|recycling endosome membrane	anion:anion antiporter activity|bicarbonate transmembrane transporter activity|chloride channel activity|oxalate transmembrane transporter activity|sulfate transmembrane transporter activity			ovary(2)	2			BRCA - Breast invasive adenocarcinoma(11;0.00802)			ACCAATATGGAAAACACATAT	0.303		NA											17	56	---	---	---	---	NA	NA	NA	NA
ZXDA	7789	broad.mit.edu	37	X	57935195	57935196	+	Frame_Shift_Del	DEL	AG	AG	-			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chrX:57935195_57935196delAG	uc004dve.2	-	1	1872_1873	c.1659_1660delCT	c.(1657-1662)CTCTTCfs	p.L553fs		NM_007156	NP_009087	P98168	ZXDA_HUMAN	zinc finger, X-linked, duplicated A	553_554	C2H2-type 10.|Required for interaction with ZXDC.				positive regulation of transcription, DNA-dependent	nucleus	C2H2 zinc finger domain binding|identical protein binding|nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1						TTGGATGTGAAGAGTTTATTAC	0.485		NA											10	24	---	---	---	---	NA	NA	NA	NA