Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	isArtifactMode	oxoGCut
VSIG8	391123	broad.mit.edu	37	1	159827930	159827930	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7372-01A-11D-2012-08	TCGA-CR-7372-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9032c525-9bed-47f9-b9f2-ecce4593ea37	067eb6e6-2211-467d-993f-f16368e1da5d	g.chr1:159827930C>T	uc001fuh.2	-	3	516	c.380G>A	c.(379-381)CGG>CAG	p.R127Q	C1orf204_uc001fug.1_5'Flank	NM_001013661	NP_001013683	Q5VU13	VSIG8_HUMAN	V-set and immunoglobulin domain containing 8	127	Extracellular (Potential).|Ig-like V-type 1.					integral to membrane				central_nervous_system(1)	1	all_hematologic(112;0.0597)					CTTCTTCACCCGGCACTCATA	0.562		NA											7	34					0	0	0	0
PTPRC	5788	broad.mit.edu	37	1	198723447	198723447	+	Nonsense_Mutation	SNP	G	G	T			TCGA-CR-7372-01A-11D-2012-08	TCGA-CR-7372-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9032c525-9bed-47f9-b9f2-ecce4593ea37	067eb6e6-2211-467d-993f-f16368e1da5d	g.chr1:198723447G>T	uc001gur.1	+	32	3733	c.3553G>T	c.(3553-3555)GAA>TAA	p.E1185*	PTPRC_uc001gus.1_Nonsense_Mutation_p.E1137*|PTPRC_uc001gut.1_Nonsense_Mutation_p.E1024*	NM_002838	NP_002829	P08575	PTPRC_HUMAN	protein tyrosine phosphatase, receptor type, C	1185	Tyrosine-protein phosphatase 2.|Cytoplasmic (Potential).				axon guidance|B cell proliferation|B cell receptor signaling pathway|defense response to virus|immunoglobulin biosynthetic process|negative regulation of cytokine-mediated signaling pathway|negative regulation of protein kinase activity|negative regulation of T cell mediated cytotoxicity|positive regulation of antigen receptor-mediated signaling pathway|positive regulation of B cell proliferation|positive regulation of protein kinase activity|positive regulation of T cell proliferation|regulation of S phase|release of sequestered calcium ion into cytosol|T cell differentiation|T cell receptor signaling pathway	focal adhesion|integral to plasma membrane|membrane raft	protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			breast(4)|skin(3)|ovary(2)|lung(1)|kidney(1)|pancreas(1)	12						AAATCTCTTAGAAAGTGCGGA	0.383		NA											13	31					0.00136819	0.00151071	1	0
DISP1	84976	broad.mit.edu	37	1	223177009	223177009	+	Nonsense_Mutation	SNP	C	C	A			TCGA-CR-7372-01A-11D-2012-08	TCGA-CR-7372-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9032c525-9bed-47f9-b9f2-ecce4593ea37	067eb6e6-2211-467d-993f-f16368e1da5d	g.chr1:223177009C>A	uc001hnu.1	+	8	2417	c.2270C>A	c.(2269-2271)TCG>TAG	p.S757*		NM_032890	NP_116279	Q96F81	DISP1_HUMAN	dispatched A	757					diaphragm development|protein homotrimerization|regulation of protein secretion|smoothened signaling pathway	basolateral plasma membrane|integral to membrane	hedgehog receptor activity|peptide transporter activity				0				GBM - Glioblastoma multiforme(131;0.102)		GTGTTCCGGTCGTCCCATCCT	0.463		NA											12	67					1.09e-07	1.3e-07	1	0
KIAA1217	56243	broad.mit.edu	37	10	24834796	24834796	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7372-01A-11D-2012-08	TCGA-CR-7372-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9032c525-9bed-47f9-b9f2-ecce4593ea37	067eb6e6-2211-467d-993f-f16368e1da5d	g.chr10:24834796C>T	uc001iru.3	+	21	5778	c.5375C>T	c.(5374-5376)CCT>CTT	p.P1792L	KIAA1217_uc001irs.2_Missense_Mutation_p.P1113L|KIAA1217_uc001irt.3_Missense_Mutation_p.P1158L|KIAA1217_uc010qcy.1_Missense_Mutation_p.P1223L|KIAA1217_uc010qcz.1_Missense_Mutation_p.P1198L|KIAA1217_uc001irw.2_3'UTR|KIAA1217_uc001irz.2_3'UTR|KIAA1217_uc001irx.2_3'UTR|KIAA1217_uc001iry.2_3'UTR	NM_019590	NP_062536	Q5T5P2	SKT_HUMAN	sickle tail isoform 1	1792					embryonic skeletal system development	cytoplasm				ovary(5)|skin(2)	7						GACTTTAAGCCTACTTCCCCC	0.493		NA											14	107					0	0	0	0
TDRD1	56165	broad.mit.edu	37	10	115962045	115962045	+	Silent	SNP	G	G	A			TCGA-CR-7372-01A-11D-2012-08	TCGA-CR-7372-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9032c525-9bed-47f9-b9f2-ecce4593ea37	067eb6e6-2211-467d-993f-f16368e1da5d	g.chr10:115962045G>A	uc001lbg.1	+	6	837	c.684G>A	c.(682-684)GAG>GAA	p.E228E	TDRD1_uc001lbf.2_Silent_p.E219E|TDRD1_uc001lbh.1_Silent_p.E219E|TDRD1_uc001lbi.1_Silent_p.E219E|TDRD1_uc010qsc.1_5'Flank|TDRD1_uc001lbj.2_5'Flank	NM_198795	NP_942090	Q9BXT4	TDRD1_HUMAN	tudor domain containing 1	228					DNA methylation involved in gamete generation|gene silencing by RNA|germ cell development|meiosis|multicellular organismal development|piRNA metabolic process|spermatogenesis	pi-body	nucleic acid binding|protein binding|zinc ion binding				0		Colorectal(252;0.172)|Breast(234;0.188)		Epithelial(162;0.0343)|all cancers(201;0.0754)		AGGATGTGGAGGTAAACAATA	0.264		NA											11	21					0	0	0	0
IPO7	10527	broad.mit.edu	37	11	9445348	9445348	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7372-01A-11D-2012-08	TCGA-CR-7372-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9032c525-9bed-47f9-b9f2-ecce4593ea37	067eb6e6-2211-467d-993f-f16368e1da5d	g.chr11:9445348C>A	uc001mho.2	+	10	1208	c.1066C>A	c.(1066-1068)CCA>ACA	p.P356T		NM_006391	NP_006382	O95373	IPO7_HUMAN	importin 7	356					interspecies interaction between organisms|signal transduction	Golgi apparatus|nuclear pore|soluble fraction	protein transporter activity|Ran GTPase binding|small GTPase regulator activity			lung(1)|breast(1)	2				all cancers(16;8.29e-09)|Epithelial(150;4.76e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0217)		TGTTATTTTTCCATTGATGTG	0.308		NA											13	45					4.38e-07	5.16e-07	1	0
OR5M8	219484	broad.mit.edu	37	11	56258616	56258616	+	Silent	SNP	A	A	G			TCGA-CR-7372-01A-11D-2012-08	TCGA-CR-7372-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9032c525-9bed-47f9-b9f2-ecce4593ea37	067eb6e6-2211-467d-993f-f16368e1da5d	g.chr11:56258616A>G	uc001nix.1	-	1	231	c.231T>C	c.(229-231)ACT>ACC	p.T77T		NM_001005282	NP_001005282	Q8NGP6	OR5M8_HUMAN	olfactory receptor, family 5, subfamily M,	77	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1	Esophageal squamous(21;0.00352)					GCATCTTTGGAGTCACATTGG	0.468		NA											8	89					0	0	0	0
OR5M8	219484	broad.mit.edu	37	11	56258645	56258645	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7372-01A-11D-2012-08	TCGA-CR-7372-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9032c525-9bed-47f9-b9f2-ecce4593ea37	067eb6e6-2211-467d-993f-f16368e1da5d	g.chr11:56258645C>G	uc001nix.1	-	1	202	c.202G>C	c.(202-204)GTG>CTG	p.V68L		NM_001005282	NP_001005282	Q8NGP6	OR5M8_HUMAN	olfactory receptor, family 5, subfamily M,	68	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1	Esophageal squamous(21;0.00352)					CACAGATCCACGAAGGATAAG	0.493		NA											8	100					0	0	0	0
PRB4	5545	broad.mit.edu	37	12	11461743	11461743	+	Silent	SNP	T	T	C			TCGA-CR-7372-01A-11D-2012-08	TCGA-CR-7372-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9032c525-9bed-47f9-b9f2-ecce4593ea37	067eb6e6-2211-467d-993f-f16368e1da5d	g.chr12:11461743T>C	uc001qzf.1	-	3	208	c.174A>G	c.(172-174)CAA>CAG	p.Q58Q	PRB4_uc001qzt.2_Silent_p.Q58Q	NM_002723	NP_002714	P10163	PRB4_HUMAN	proline-rich protein BstNI subfamily 4	58	9.5 X 21 AA tandem repeats of K-P-[EQ]- [GR]-[PR]-[PR]-P-Q-G-G-N-Q-[PS]-[QH]- [RG]-[PT]-P-P-[PH]-P-G.|2.					extracellular region				ovary(1)	1						GGGGTGGTCCTTGTGGCTTTC	0.622		NA								HNSCC(22;0.051)			94	290					0	0	0	0
GRIP1	23426	broad.mit.edu	37	12	66786267	66786267	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7372-01A-11D-2012-08	TCGA-CR-7372-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9032c525-9bed-47f9-b9f2-ecce4593ea37	067eb6e6-2211-467d-993f-f16368e1da5d	g.chr12:66786267C>A	uc001stk.2	-	18	2370	c.2129G>T	c.(2128-2130)AGC>ATC	p.S710I	GRIP1_uc010sta.1_Missense_Mutation_p.S654I|GRIP1_uc001stj.2_Missense_Mutation_p.S492I|GRIP1_uc001stl.1_Missense_Mutation_p.S602I|GRIP1_uc001stm.2_Missense_Mutation_p.S710I	NM_021150	NP_066973	Q9Y3R0	GRIP1_HUMAN	glutamate receptor interacting protein 1	762					androgen receptor signaling pathway|intracellular signal transduction|positive regulation of transcription, DNA-dependent|synaptic transmission	cell junction|cytoplasmic membrane-bounded vesicle|cytosol|endoplasmic reticulum|postsynaptic membrane	androgen receptor binding|beta-catenin binding|protein C-terminus binding|receptor signaling complex scaffold activity|transcription coactivator activity			ovary(2)	2			GBM - Glioblastoma multiforme(2;0.00069)	GBM - Glioblastoma multiforme(28;0.0933)		CTTCTTGGGGCTCGATGCTGA	0.453		NA											13	99					9.31e-06	1.07e-05	1	0
POLE	5426	broad.mit.edu	37	12	133215740	133215740	+	Silent	SNP	G	G	A			TCGA-CR-7372-01A-11D-2012-08	TCGA-CR-7372-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9032c525-9bed-47f9-b9f2-ecce4593ea37	067eb6e6-2211-467d-993f-f16368e1da5d	g.chr12:133215740G>A	uc001uks.1	-	40	5567	c.5523C>T	c.(5521-5523)CTC>CTT	p.L1841L	POLE_uc001ukq.1_Silent_p.L51L|POLE_uc001ukr.1_Silent_p.L645L|POLE_uc010tbq.1_RNA	NM_006231	NP_006222	Q07864	DPOE1_HUMAN	DNA-directed DNA polymerase epsilon	1841					base-excision repair, gap-filling|DNA synthesis involved in DNA repair|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	nucleoplasm	chromatin binding|DNA binding|DNA-directed DNA polymerase activity|nucleotide binding|protein binding|zinc ion binding			ovary(3)|skin(3)|lung(1)|central_nervous_system(1)	8	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0416)		OV - Ovarian serous cystadenocarcinoma(86;5.22e-08)|Epithelial(86;4.03e-07)|all cancers(50;1.18e-05)		TCATGTTGTGGAGTGTGCGGT	0.582		NA						DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage			OREG0022269	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	12	35					0	0	0	0
DIAPH3	81624	broad.mit.edu	37	13	60384961	60384961	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7372-01A-11D-2012-08	TCGA-CR-7372-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9032c525-9bed-47f9-b9f2-ecce4593ea37	067eb6e6-2211-467d-993f-f16368e1da5d	g.chr13:60384961G>A	uc001vht.2	-	25	3343	c.3124C>T	c.(3124-3126)CGC>TGC	p.R1042C	DIAPH3_uc001vhu.2_Missense_Mutation_p.R779C	NM_001042517	NP_001035982	Q9NSV4	DIAP3_HUMAN	diaphanous homolog 3 isoform a	1042	Potential.				actin cytoskeleton organization		actin binding|Rho GTPase binding			ovary(2)	2		Breast(118;0.052)|Prostate(109;0.103)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;2.77e-05)		TTTTGTTGGCGTTCGAGTCTT	0.323		NA											3	33					0	0	0	0
NALCN	259232	broad.mit.edu	37	13	101714441	101714441	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7372-01A-11D-2012-08	TCGA-CR-7372-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9032c525-9bed-47f9-b9f2-ecce4593ea37	067eb6e6-2211-467d-993f-f16368e1da5d	g.chr13:101714441C>T	uc001vox.1	-	41	4823	c.4634G>A	c.(4633-4635)CGG>CAG	p.R1545Q		NM_052867	NP_443099	Q8IZF0	NALCN_HUMAN	voltage gated channel like 1	1545	Cytoplasmic (Potential).					integral to membrane	sodium channel activity|voltage-gated ion channel activity	p.R1545W(1)		ovary(8)|breast(4)|skin(2)|pancreas(1)|central_nervous_system(1)	16	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					CAAGCTCTTCCGGATGTCCAC	0.542		NA											13	43					0	0	0	0
TP53BP1	7158	broad.mit.edu	37	15	43705366	43705366	+	Silent	SNP	G	G	A			TCGA-CR-7372-01A-11D-2012-08	TCGA-CR-7372-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9032c525-9bed-47f9-b9f2-ecce4593ea37	067eb6e6-2211-467d-993f-f16368e1da5d	g.chr15:43705366G>A	uc001zrs.2	-	24	5389	c.5241C>T	c.(5239-5241)AGC>AGT	p.S1747S	TP53BP1_uc010udp.1_Silent_p.S1745S|TP53BP1_uc001zrq.3_Silent_p.S1750S|TP53BP1_uc001zrr.3_Silent_p.S1752S|TP53BP1_uc001zrp.2_Silent_p.S164S	NM_005657	NP_005648	Q12888	TP53B_HUMAN	tumor protein p53 binding protein 1 isoform 3	1747	BRCT 1.				double-strand break repair via homologous recombination|positive regulation of transcription from RNA polymerase II promoter	condensed chromosome kinetochore|cytoplasm|nucleoplasm	p53 binding|RNA polymerase II activating transcription factor binding|RNA polymerase II transcription cofactor activity			ovary(2)|skin(2)|large_intestine(1)|pancreas(1)|kidney(1)	7		all_cancers(109;6.94e-11)|all_epithelial(112;2.69e-09)|Lung NSC(122;7.86e-07)|all_lung(180;7.84e-06)|Melanoma(134;0.0728)		GBM - Glioblastoma multiforme(94;1.59e-06)		GTTTGGAGCGGCTGGCCAACT	0.537		NA						Direct_reversal_of_damage|Other_conserved_DNA_damage_response_genes					3	64					0	0	0	0
MAP1A	4130	broad.mit.edu	37	15	43815758	43815758	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7372-01A-11D-2012-08	TCGA-CR-7372-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9032c525-9bed-47f9-b9f2-ecce4593ea37	067eb6e6-2211-467d-993f-f16368e1da5d	g.chr15:43815758G>T	uc001zrt.2	+	4	2554	c.2087G>T	c.(2086-2088)CGG>CTG	p.R696L		NM_002373	NP_002364	P78559	MAP1A_HUMAN	microtubule-associated protein 1A	696						cytoplasm|microtubule|microtubule associated complex	protein binding|structural molecule activity			ovary(3)|breast(3)|pancreas(2)|skin(1)	9		all_cancers(109;1.03e-14)|all_epithelial(112;2.23e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.05e-06)	Estramustine(DB01196)	CCAAGGAGCCGGGAGGCTTTT	0.547		NA											7	24					8.13e-05	9.23e-05	1	0
DUOX1	53905	broad.mit.edu	37	15	45439652	45439652	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7372-01A-11D-2012-08	TCGA-CR-7372-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9032c525-9bed-47f9-b9f2-ecce4593ea37	067eb6e6-2211-467d-993f-f16368e1da5d	g.chr15:45439652G>A	uc001zus.1	+	20	2690	c.2344G>A	c.(2344-2346)GAC>AAC	p.D782N	DUOX1_uc001zut.1_Missense_Mutation_p.D782N|DUOX1_uc010bee.1_Missense_Mutation_p.D162N|DUOX1_uc001zuu.2_5'Flank	NM_017434	NP_059130	Q9NRD9	DUOX1_HUMAN	dual oxidase 1 precursor	782	Cytoplasmic (Potential).				cuticle development|cytokine-mediated signaling pathway|hormone biosynthetic process|hydrogen peroxide biosynthetic process|hydrogen peroxide catabolic process|response to cAMP|superoxide anion generation	apical plasma membrane|integral to membrane	calcium ion binding|electron carrier activity|flavin adenine dinucleotide binding|heme binding|NAD(P)H oxidase activity|NADP binding|peroxidase activity			ovary(5)|skin(2)|breast(1)	8		all_cancers(109;5.7e-11)|all_epithelial(112;4.65e-09)|Lung NSC(122;3.55e-06)|all_lung(180;2.56e-05)|Melanoma(134;0.027)		all cancers(107;5.77e-18)|GBM - Glioblastoma multiforme(94;5.11e-07)|COAD - Colon adenocarcinoma(120;0.071)|Colorectal(133;0.0717)		CAACCAGGCCGACGCAGGGAC	0.637		NA											3	19					0	0	0	0
UNC13C	440279	broad.mit.edu	37	15	54542506	54542506	+	Silent	SNP	G	G	A			TCGA-CR-7372-01A-11D-2012-08	TCGA-CR-7372-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9032c525-9bed-47f9-b9f2-ecce4593ea37	067eb6e6-2211-467d-993f-f16368e1da5d	g.chr15:54542506G>A	uc002ack.2	+	6	3312	c.3312G>A	c.(3310-3312)ACG>ACA	p.T1104T		NM_001080534	NP_001074003	Q8NB66	UN13C_HUMAN	unc-13 homolog C	1104	Phorbol-ester/DAG-type.				exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			ovary(5)|pancreas(2)	7				GBM - Glioblastoma multiforme(80;0.0789)|all cancers(107;0.124)		AGGTCTGGACGGCTACCACAC	0.493		NA											17	37					0	0	0	0
POLG	5428	broad.mit.edu	37	15	89871966	89871966	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CR-7372-01A-11D-2012-08	TCGA-CR-7372-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9032c525-9bed-47f9-b9f2-ecce4593ea37	067eb6e6-2211-467d-993f-f16368e1da5d	g.chr15:89871966G>A	uc002bns.3	-	5	1402	c.1120C>T	c.(1120-1122)CGA>TGA	p.R374*	POLG_uc002bnr.3_Nonsense_Mutation_p.R374*	NM_002693	NP_002684	P54098	DPOG1_HUMAN	DNA-directed DNA polymerase gamma	374					base-excision repair, gap-filling|cell death|DNA-dependent DNA replication	mitochondrial nucleoid	DNA binding|DNA-directed DNA polymerase activity|protease binding			ovary(1)|lung(1)	2	Lung NSC(78;0.0472)|all_lung(78;0.089)		STAD - Stomach adenocarcinoma(125;0.165)			AACAGTTCTCGAGGCTCCTTC	0.567		NA						DNA_polymerases_(catalytic_subunits)					8	187					0	0	0	0
SEC14L5	9717	broad.mit.edu	37	16	5058627	5058627	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7372-01A-11D-2012-08	TCGA-CR-7372-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9032c525-9bed-47f9-b9f2-ecce4593ea37	067eb6e6-2211-467d-993f-f16368e1da5d	g.chr16:5058627G>T	uc002cye.2	+	14	1958	c.1778G>T	c.(1777-1779)TGC>TTC	p.C593F		NM_014692	NP_055507	O43304	S14L5_HUMAN	SEC14-like 5	593	GOLD.					integral to membrane|intracellular	transporter activity				0						CCCCTTGTCTGCCGGGAGGGG	0.468		NA											22	83					1.97e-08	2.39e-08	1	0
CNOT1	23019	broad.mit.edu	37	16	58633241	58633241	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-7372-01A-11D-2012-08	TCGA-CR-7372-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9032c525-9bed-47f9-b9f2-ecce4593ea37	067eb6e6-2211-467d-993f-f16368e1da5d	g.chr16:58633241T>C	uc002env.2	-	2	294	c.1A>G	c.(1-3)ATG>GTG	p.M1V	CNOT1_uc002enw.2_RNA|CNOT1_uc002enu.3_Missense_Mutation_p.M1V|CNOT1_uc002enx.2_Missense_Mutation_p.M1V|CNOT1_uc002enz.1_5'UTR	NM_016284	NP_057368	A5YKK6	CNOT1_HUMAN	CCR4-NOT transcription complex, subunit 1	1					nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol				ovary(4)|central_nervous_system(2)	6				Kidney(780;0.0722)|OV - Ovarian serous cystadenocarcinoma(108;0.173)|Epithelial(162;0.239)		TCAAGATTCATTGCTGGTTGG	0.498		NA											20	56					0	0	0	0
AP1G1	164	broad.mit.edu	37	16	71784153	71784153	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-7372-01A-11D-2012-08	TCGA-CR-7372-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9032c525-9bed-47f9-b9f2-ecce4593ea37	067eb6e6-2211-467d-993f-f16368e1da5d	g.chr16:71784153A>G	uc010cgg.2	-	14	1681	c.1367T>C	c.(1366-1368)GTC>GCC	p.V456A	AP1G1_uc002fba.2_Missense_Mutation_p.V459A|AP1G1_uc002fbb.2_Missense_Mutation_p.V479A|AP1G1_uc002faz.2_5'Flank	NM_001128	NP_001119	O43747	AP1G1_HUMAN	adaptor-related protein complex 1, gamma 1	456					endocytosis|intracellular protein transport|post-Golgi vesicle-mediated transport|regulation of defense response to virus by virus|viral reproduction	clathrin adaptor complex|clathrin coated vesicle membrane|cytosol|Golgi membrane|lysosomal membrane|recycling endosome	kinesin binding|protein transporter activity			ovary(2)	2		Ovarian(137;0.125)				CAGGCGCTGGACAGTATAGGC	0.378		NA											19	157					0	0	0	0
DSC2	1824	broad.mit.edu	37	18	28651727	28651727	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7372-01A-11D-2012-08	TCGA-CR-7372-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9032c525-9bed-47f9-b9f2-ecce4593ea37	067eb6e6-2211-467d-993f-f16368e1da5d	g.chr18:28651727C>T	uc002kwl.3	-	13	2423	c.1969G>A	c.(1969-1971)GGC>AGC	p.G657S	DSC2_uc002kwk.3_Missense_Mutation_p.G657S	NM_024422	NP_077740	Q02487	DSC2_HUMAN	desmocollin 2 isoform Dsc2a preproprotein	657	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			ovary(2)|skin(1)	3			OV - Ovarian serous cystadenocarcinoma(10;0.0241)			CTAGACATGCCAAGTCTATCT	0.408		NA											9	16					0	0	0	0
DTNA	1837	broad.mit.edu	37	18	32443990	32443990	+	Silent	SNP	A	A	G			TCGA-CR-7372-01A-11D-2012-08	TCGA-CR-7372-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9032c525-9bed-47f9-b9f2-ecce4593ea37	067eb6e6-2211-467d-993f-f16368e1da5d	g.chr18:32443990A>G	uc010dmn.1	+	16	1627	c.1626A>G	c.(1624-1626)CTA>CTG	p.L542L	DTNA_uc010xbx.1_Silent_p.L292L|DTNA_uc002kxv.3_Silent_p.L485L|DTNA_uc002kxw.2_Silent_p.L485L|DTNA_uc010dmj.2_Silent_p.L482L|DTNA_uc002kxz.2_Silent_p.L482L|DTNA_uc002kxy.2_Silent_p.L482L|DTNA_uc010dml.2_Silent_p.L482L|DTNA_uc002kyb.3_Silent_p.L539L|DTNA_uc010dmm.2_Silent_p.L542L|DTNA_uc010xby.1_Silent_p.L232L|DTNA_uc010dmo.2_Silent_p.*163*|DTNA_uc002kyd.3_Silent_p.L164L|DTNA_uc010xbz.1_Silent_p.L251L|DTNA_uc010xca.1_Silent_p.L194L|DTNA_uc002kye.2_Silent_p.L190L	NM_001390	NP_001381	Q9Y4J8	DTNA_HUMAN	dystrobrevin alpha isoform 1	542	Potential.				neuromuscular synaptic transmission|signal transduction|striated muscle contraction	cell junction|cytoplasm|synapse	calcium ion binding|protein binding|zinc ion binding				0						GGAGAGAGCTAATGGTCCAGT	0.458		NA											7	8					0	0	0	0
ATP8B3	148229	broad.mit.edu	37	19	1784856	1784856	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CR-7372-01A-11D-2012-08	TCGA-CR-7372-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9032c525-9bed-47f9-b9f2-ecce4593ea37	067eb6e6-2211-467d-993f-f16368e1da5d	g.chr19:1784856G>A	uc002ltw.2	-	28	3856	c.3622C>T	c.(3622-3624)CGA>TGA	p.R1208*	ATP8B3_uc002ltv.2_Nonsense_Mutation_p.R1171*|ATP8B3_uc002ltx.2_RNA	NM_138813	NP_620168	O60423	AT8B3_HUMAN	ATPase, class I, type 8B, member 3	1208	Cytoplasmic (Potential).				ATP biosynthetic process		ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		AAGATGACTCGGAGGGCCAGG	0.622		NA											3	23					0	0	0	0
ZNF792	126375	broad.mit.edu	37	19	35450296	35450296	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7372-01A-11D-2012-08	TCGA-CR-7372-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9032c525-9bed-47f9-b9f2-ecce4593ea37	067eb6e6-2211-467d-993f-f16368e1da5d	g.chr19:35450296G>T	uc002nxh.1	-	4	850	c.463C>A	c.(463-465)CCC>ACC	p.P155T		NM_175872	NP_787068	Q3KQV3	ZN792_HUMAN	zinc finger protein 792	155					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_lung(56;4.18e-08)|Lung NSC(56;6.62e-08)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0849)			TTCTGCCTGGGATGTGTTGTC	0.507		NA											76	112					3e-28	3.79e-28	1	0
CLIP3	25999	broad.mit.edu	37	19	36515479	36515479	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-7372-01A-11D-2012-08	TCGA-CR-7372-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9032c525-9bed-47f9-b9f2-ecce4593ea37	067eb6e6-2211-467d-993f-f16368e1da5d	g.chr19:36515479A>G	uc010eeq.1	-	6	1019	c.737T>C	c.(736-738)CTG>CCG	p.L246P	uc002ocy.2_Intron|CLIP3_uc002ocz.1_Missense_Mutation_p.L246P	NM_015526	NP_056341	Q96DZ5	CLIP3_HUMAN	CAP-GLY domain containing linker protein 3	246					chaperone-mediated protein transport|fat cell differentiation|membrane biogenesis|negative regulation of microtubule polymerization|peptidyl-L-cysteine S-palmitoylation|positive regulation of apoptosis|positive regulation of endocytosis|positive regulation of establishment of protein localization in plasma membrane|positive regulation of glucose transport|positive regulation of protein phosphorylation	early endosome membrane|Golgi stack|membrane raft|microsome|plasma membrane|recycling endosome membrane|trans-Golgi network membrane	ganglioside binding|microtubule binding			ovary(2)|pancreas(1)|skin(1)	4	Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.06)			TGCCTTGTCCAGGGACATGTC	0.612		NA											3	59					0	0	0	0
CIC	23152	broad.mit.edu	37	19	42793503	42793503	+	Silent	SNP	G	G	A			TCGA-CR-7372-01A-11D-2012-08	TCGA-CR-7372-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9032c525-9bed-47f9-b9f2-ecce4593ea37	067eb6e6-2211-467d-993f-f16368e1da5d	g.chr19:42793503G>A	uc002otf.1	+	8	1345	c.1305G>A	c.(1303-1305)ACG>ACA	p.T435T		NM_015125	NP_055940	Q96RK0	CIC_HUMAN	capicua homolog	435					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding			ovary(4)|breast(4)|lung(1)|central_nervous_system(1)|skin(1)	11		Prostate(69;0.00682)				AGGACATGACGAGTGATGAGG	0.642		NA	T	DUX4	soft tissue sarcoma								9	22					0	0	0	0
ZFP112	7771	broad.mit.edu	37	19	44832521	44832521	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7372-01A-11D-2012-08	TCGA-CR-7372-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9032c525-9bed-47f9-b9f2-ecce4593ea37	067eb6e6-2211-467d-993f-f16368e1da5d	g.chr19:44832521G>T	uc010ejj.2	-	5	1920	c.1807C>A	c.(1807-1809)CAC>AAC	p.H603N	ZFP112_uc002ozc.3_Missense_Mutation_p.H597N|ZFP112_uc010xwy.1_Missense_Mutation_p.H620N|ZFP112_uc010xwz.1_Missense_Mutation_p.H602N	NM_001083335	NP_001076804	Q9UJU3	ZF112_HUMAN	zinc finger protein 228 isoform 1	603	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)|skin(2)	5						TCTCCAGTGTGAACTCTCTGA	0.478		NA											25	111					2.8e-10	3.45e-10	1	0
ZNF473	25888	broad.mit.edu	37	19	50549981	50549981	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CR-7372-01A-11D-2012-08	TCGA-CR-7372-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9032c525-9bed-47f9-b9f2-ecce4593ea37	067eb6e6-2211-467d-993f-f16368e1da5d	g.chr19:50549981C>T	uc002prn.2	+	5	2518	c.2281C>T	c.(2281-2283)CAG>TAG	p.Q761*	ZNF473_uc002prm.2_Nonsense_Mutation_p.Q761*|ZNF473_uc010ybo.1_Nonsense_Mutation_p.Q749*	NM_001006656	NP_001006657	Q8WTR7	ZN473_HUMAN	zinc finger protein 473	761	C2H2-type 17.				histone mRNA 3'-end processing|regulation of transcription, DNA-dependent|termination of RNA polymerase II transcription	Cajal body	DNA binding|protein binding|zinc ion binding			ovary(1)|central_nervous_system(1)	2		all_neural(266;0.0459)|Ovarian(192;0.0728)		GBM - Glioblastoma multiforme(134;0.00111)|OV - Ovarian serous cystadenocarcinoma(262;0.0058)		TTATGTTTGTCAGGAATGCGG	0.522		NA									OREG0025632	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	11	84					0	0	0	0
SFRS7	6432	broad.mit.edu	37	2	38976812	38976812	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7372-01A-11D-2012-08	TCGA-CR-7372-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9032c525-9bed-47f9-b9f2-ecce4593ea37	067eb6e6-2211-467d-993f-f16368e1da5d	g.chr2:38976812G>A	uc002rqz.2	-	3	483	c.245C>T	c.(244-246)TCG>TTG	p.S82L	SFRS7_uc002rra.2_RNA|SFRS7_uc010ynp.1_Missense_Mutation_p.S82L|GEMIN6_uc002rrb.2_5'Flank	NM_001031684	NP_001026854	Q16629	SRSF7_HUMAN	splicing factor, arginine/serine-rich 7	82	RRM.				mRNA 3'-end processing|mRNA export from nucleus|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	nucleoplasm	nucleotide binding|protein binding|RNA binding|zinc ion binding				0		all_hematologic(82;0.248)				CATGCCTGTCGATAGTTCAAC	0.393		NA											19	41					0	0	0	0
BUB1	699	broad.mit.edu	37	2	111399701	111399701	+	Missense_Mutation	SNP	A	A	C			TCGA-CR-7372-01A-11D-2012-08	TCGA-CR-7372-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9032c525-9bed-47f9-b9f2-ecce4593ea37	067eb6e6-2211-467d-993f-f16368e1da5d	g.chr2:111399701A>C	uc002tgc.2	-	20	2570	c.2458T>G	c.(2458-2460)TTA>GTA	p.L820V	BUB1_uc010yxh.1_Missense_Mutation_p.L800V|BUB1_uc010fkb.2_Missense_Mutation_p.L820V	NM_004336	NP_004327	O43683	BUB1_HUMAN	budding uninhibited by benzimidazoles 1	820	Protein kinase.				apoptosis|cell division|chromosome segregation|interspecies interaction between organisms|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|regulation of sister chromatid cohesion	condensed chromosome kinetochore|cytosol	ATP binding|protein binding|protein serine/threonine kinase activity			lung(2)|breast(2)|stomach(1)|ovary(1)|kidney(1)	7		Ovarian(717;0.0822)		BRCA - Breast invasive adenocarcinoma(221;0.0556)		TTTACCTTTAAAACAAATTTC	0.353		NA											3	17					0	0	0	0
LRP1B	53353	broad.mit.edu	37	2	141081499	141081499	+	Missense_Mutation	SNP	T	T	G			TCGA-CR-7372-01A-11D-2012-08	TCGA-CR-7372-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9032c525-9bed-47f9-b9f2-ecce4593ea37	067eb6e6-2211-467d-993f-f16368e1da5d	g.chr2:141081499T>G	uc002tvj.1	-	81	13449	c.12477A>C	c.(12475-12477)AAA>AAC	p.K4159N		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	4159	Extracellular (Potential).				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		TCAAAACACCTTTTGTTTTAT	0.269		NA								TSP Lung(27;0.18)			15	27					0	0	0	0
KIF1A	547	broad.mit.edu	37	2	241737138	241737138	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7372-01A-11D-2012-08	TCGA-CR-7372-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9032c525-9bed-47f9-b9f2-ecce4593ea37	067eb6e6-2211-467d-993f-f16368e1da5d	g.chr2:241737138C>T	uc002vzy.2	-	2	178	c.32G>A	c.(31-33)CGG>CAG	p.R11Q	KIF1A_uc010fzk.2_Missense_Mutation_p.R11Q|KIF1A_uc002vzz.1_Missense_Mutation_p.R11Q	NM_004321	NP_004312	Q12756	KIF1A_HUMAN	axonal transport of synaptic vesicles	11	Kinesin-motor.				anterograde axon cargo transport	cytoplasm|microtubule|nucleus	ATP binding|microtubule motor activity			lung(1)	1		all_epithelial(40;1.35e-15)|Breast(86;2.14e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0295)|all_neural(83;0.0459)|Lung NSC(271;0.0942)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;6.12e-30)|all cancers(36;3.46e-27)|OV - Ovarian serous cystadenocarcinoma(60;1.38e-14)|Kidney(56;5e-09)|KIRC - Kidney renal clear cell carcinoma(57;5e-08)|BRCA - Breast invasive adenocarcinoma(100;5.87e-06)|Lung(119;0.00209)|LUSC - Lung squamous cell carcinoma(224;0.00902)|Colorectal(34;0.0282)|COAD - Colon adenocarcinoma(134;0.176)		GGGGCGGACCCGCACCGCCAC	0.602		NA											6	15					0	0	0	0
SLC5A1	6523	broad.mit.edu	37	22	32498104	32498104	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7372-01A-11D-2012-08	TCGA-CR-7372-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9032c525-9bed-47f9-b9f2-ecce4593ea37	067eb6e6-2211-467d-993f-f16368e1da5d	g.chr22:32498104C>A	uc003amc.2	+	13	1777	c.1545C>A	c.(1543-1545)AGC>AGA	p.S515R	SLC5A1_uc011alz.1_Missense_Mutation_p.S388R	NM_000343	NP_000334	P13866	SC5A1_HUMAN	solute carrier family 5 (sodium/glucose	515	Extracellular (Potential).				carbohydrate metabolic process	integral to plasma membrane	glucose:sodium symporter activity|protein binding			skin(1)	1						TGGAGCCCAGCAACTGTCCCA	0.498		NA											15	130					2.32e-09	2.84e-09	1	0
ALS2CL	259173	broad.mit.edu	37	3	46728524	46728524	+	Silent	SNP	G	G	A			TCGA-CR-7372-01A-11D-2012-08	TCGA-CR-7372-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9032c525-9bed-47f9-b9f2-ecce4593ea37	067eb6e6-2211-467d-993f-f16368e1da5d	g.chr3:46728524G>A	uc003cqa.1	-	5	673	c.483C>T	c.(481-483)CAC>CAT	p.H161H	ALS2CL_uc003cqb.1_Silent_p.H161H|ALS2CL_uc003cqc.1_RNA	NM_147129	NP_667340	Q60I27	AL2CL_HUMAN	ALS2 C-terminal like isoform 1	161					endosome organization|regulation of Rho protein signal transduction		GTPase activator activity|identical protein binding|Rho guanyl-nucleotide exchange factor activity			breast(2)|central_nervous_system(2)|skin(1)	5				BRCA - Breast invasive adenocarcinoma(193;0.000726)|KIRC - Kidney renal clear cell carcinoma(197;0.0171)|Kidney(197;0.0202)		ACTGTTGCACGTGATGGGCGA	0.677		NA											11	15					0	0	0	0
ALCAM	214	broad.mit.edu	37	3	105260531	105260531	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7372-01A-11D-2012-08	TCGA-CR-7372-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9032c525-9bed-47f9-b9f2-ecce4593ea37	067eb6e6-2211-467d-993f-f16368e1da5d	g.chr3:105260531C>T	uc003dvx.2	+	8	1453	c.913C>T	c.(913-915)CGC>TGC	p.R305C	ALCAM_uc003dvw.1_Missense_Mutation_p.R305C|ALCAM_uc003dvy.2_Missense_Mutation_p.R305C|ALCAM_uc011bhh.1_Missense_Mutation_p.R254C|ALCAM_uc010hpp.2_Intron|ALCAM_uc003dvz.2_5'Flank	NM_001627	NP_001618	Q13740	CD166_HUMAN	activated leukocyte cell adhesion molecule	305	Extracellular (Potential).|Ig-like C2-type 1.				cell adhesion|signal transduction	integral to membrane	receptor binding			ovary(2)|breast(1)	3						GGATGTGAGGCGCAATGCAAC	0.423		NA											6	43					0	0	0	0
GTF2E1	2960	broad.mit.edu	37	3	120469828	120469828	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7372-01A-11D-2012-08	TCGA-CR-7372-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9032c525-9bed-47f9-b9f2-ecce4593ea37	067eb6e6-2211-467d-993f-f16368e1da5d	g.chr3:120469828G>T	uc003edz.3	+	2	543	c.429G>T	c.(427-429)CAG>CAT	p.Q143H	GTF2E1_uc003edy.2_Missense_Mutation_p.Q143H	NM_005513	NP_005504	P29083	T2EA_HUMAN	general transcription factor IIE, polypeptide 1,	143	C4-type (Potential).				interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	nucleoplasm	protein binding|zinc ion binding			ovary(1)	1				GBM - Glioblastoma multiforme(114;0.159)		AAGCTAATCAGCTCTTTGATC	0.353		NA											10	45					4.69e-08	5.65e-08	1	0
PLXND1	23129	broad.mit.edu	37	3	129284253	129284253	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7372-01A-11D-2012-08	TCGA-CR-7372-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9032c525-9bed-47f9-b9f2-ecce4593ea37	067eb6e6-2211-467d-993f-f16368e1da5d	g.chr3:129284253C>T	uc003emx.2	-	25	4551	c.4451G>A	c.(4450-4452)CGG>CAG	p.R1484Q	PLXND1_uc011blb.1_Missense_Mutation_p.R152Q	NM_015103	NP_055918	Q9Y4D7	PLXD1_HUMAN	plexin D1 precursor	1484	Cytoplasmic (Potential).				axon guidance	integral to membrane|intracellular|plasma membrane				large_intestine(1)	1						CTCTGTGCGCCGCAGCATGAG	0.602		NA											14	103					0	0	0	0
CAMK2D	817	broad.mit.edu	37	4	114469879	114469879	+	Silent	SNP	A	A	G			TCGA-CR-7372-01A-11D-2012-08	TCGA-CR-7372-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9032c525-9bed-47f9-b9f2-ecce4593ea37	067eb6e6-2211-467d-993f-f16368e1da5d	g.chr4:114469879A>G	uc003ibi.2	-	6	1207	c.348T>C	c.(346-348)TGT>TGC	p.C116C	CAMK2D_uc003ibj.2_Silent_p.C116C|CAMK2D_uc003ibk.2_Silent_p.C116C|CAMK2D_uc003ibo.3_Intron|CAMK2D_uc003ibm.2_Silent_p.C116C|CAMK2D_uc003ibn.2_Silent_p.C116C|CAMK2D_uc003ibl.2_Silent_p.C116C	NM_001221	NP_001212	Q13557	KCC2D_HUMAN	calcium/calmodulin-dependent protein kinase II	116	Protein kinase.				interferon-gamma-mediated signaling pathway|regulation of cell growth|synaptic transmission	calcium- and calmodulin-dependent protein kinase complex|cytosol|endocytic vesicle membrane|nucleoplasm|plasma membrane	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			ovary(1)	1		Ovarian(17;0.00369)|Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.000271)		TCTGCTGTATACAATGACTGC	0.358		NA											6	14					0	0	0	0
CDC23	8697	broad.mit.edu	37	5	137548688	137548688	+	Missense_Mutation	SNP	T	T	A			TCGA-CR-7372-01A-11D-2012-08	TCGA-CR-7372-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9032c525-9bed-47f9-b9f2-ecce4593ea37	067eb6e6-2211-467d-993f-f16368e1da5d	g.chr5:137548688T>A	uc003lcl.2	-	2	257	c.226A>T	c.(226-228)ATT>TTT	p.I76F	CDC23_uc003lcm.1_Missense_Mutation_p.I76F	NM_004661	NP_004652	Q9UJX2	CDC23_HUMAN	cell division cycle protein 23	76					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|G1 phase of mitotic cell cycle|mitotic cell cycle spindle assembly checkpoint|mitotic metaphase plate congression|mitotic metaphase/anaphase transition|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination|regulation of exit from mitosis	anaphase-promoting complex|cytosol|nucleoplasm	binding|ubiquitin-protein ligase activity				0			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0109)			ACCTCTGTAATAGGCGGAGGC	0.438		NA											13	81					0	0	0	0
HS3ST5	222537	broad.mit.edu	37	6	114379098	114379098	+	Nonsense_Mutation	SNP	C	C	A			TCGA-CR-7372-01A-11D-2012-08	TCGA-CR-7372-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9032c525-9bed-47f9-b9f2-ecce4593ea37	067eb6e6-2211-467d-993f-f16368e1da5d	g.chr6:114379098C>A	uc003pwg.3	-	2	396	c.364G>T	c.(364-366)GAA>TAA	p.E122*	uc003pwf.2_Intron|HS3ST5_uc003pwh.3_Nonsense_Mutation_p.E122*	NM_153612	NP_705840	Q8IZT8	HS3S5_HUMAN	heparan sulfate (glucosamine)	122	Lumenal (Potential).				heparan sulfate proteoglycan biosynthetic process, enzymatic modification|negative regulation of coagulation|protein sulfation|regulation of virion penetration into host cell	Golgi membrane|integral to membrane	3'-phosphoadenosine 5'-phosphosulfate binding|[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity|protein binding			ovary(1)|pancreas(1)	2		all_cancers(87;0.0587)|Colorectal(196;0.0676)|all_epithelial(87;0.154)		OV - Ovarian serous cystadenocarcinoma(136;0.00937)|all cancers(137;0.0117)|Epithelial(106;0.0274)|GBM - Glioblastoma multiforme(226;0.143)		AAGTGGATTTCTTGAGAGGCT	0.443		NA											16	72					1.36e-06	1.58e-06	1	0
PRKAR1B	5575	broad.mit.edu	37	7	635848	635848	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7372-01A-11D-2012-08	TCGA-CR-7372-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9032c525-9bed-47f9-b9f2-ecce4593ea37	067eb6e6-2211-467d-993f-f16368e1da5d	g.chr7:635848C>T	uc003siu.1	-	8	749	c.643G>A	c.(643-645)GTG>ATG	p.V215M	PRKAR1B_uc003siv.2_Missense_Mutation_p.V215M|PRKAR1B_uc003siw.1_Missense_Mutation_p.V215M|PRKAR1B_uc003six.1_RNA	NM_002735	NP_002726	P31321	KAP1_HUMAN	protein kinase, cAMP-dependent, regulatory, type	215	cAMP 1.				activation of phospholipase C activity|activation of protein kinase A activity|blood coagulation|cellular response to glucagon stimulus|energy reserve metabolic process|nerve growth factor receptor signaling pathway|protein phosphorylation|regulation of insulin secretion|transmembrane transport|water transport	cAMP-dependent protein kinase complex|cytosol	cAMP binding|cAMP-dependent protein kinase regulator activity				0		Ovarian(82;0.0779)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0181)|Epithelial(4;5.75e-19)|OV - Ovarian serous cystadenocarcinoma(56;2.01e-18)|all cancers(6;3.96e-16)|BRCA - Breast invasive adenocarcinoma(126;0.152)		TTGGCTTTCACGGTCGCAGCC	0.622		NA											19	63					0	0	0	0
TNRC18	84629	broad.mit.edu	37	7	5410483	5410484	+	Missense_Mutation	DNP	GC	GC	TT			TCGA-CR-7372-01A-11D-2012-08	TCGA-CR-7372-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9032c525-9bed-47f9-b9f2-ecce4593ea37	067eb6e6-2211-467d-993f-f16368e1da5d	g.chr7:5410483_5410484GC>TT	uc003soi.3	-	11	4090_4091	c.3741_3742GC>AA	c.(3739-3744)GTGCAG>GTAAAG	p.Q1248K		NM_001080495	NP_001073964	O15417	TNC18_HUMAN	trinucleotide repeat containing 18	1248							DNA binding				0		Ovarian(82;0.142)		UCEC - Uterine corpus endometrioid carcinoma (126;0.195)|OV - Ovarian serous cystadenocarcinoma(56;5.32e-15)		GGTGTCAGCTGCACCCCCAGGT	0.693		NA											11	31					0	0	0	0
OGDH	4967	broad.mit.edu	37	7	44737087	44737087	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7372-01A-11D-2012-08	TCGA-CR-7372-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9032c525-9bed-47f9-b9f2-ecce4593ea37	067eb6e6-2211-467d-993f-f16368e1da5d	g.chr7:44737087G>A	uc003tln.2	+	16	2279	c.2170G>A	c.(2170-2172)GGC>AGC	p.G724S	OGDH_uc011kbx.1_Missense_Mutation_p.G720S|OGDH_uc011kby.1_Missense_Mutation_p.G574S|OGDH_uc003tlp.2_Missense_Mutation_p.G735S|OGDH_uc011kbz.1_Missense_Mutation_p.G519S|OGDH_uc003tlo.1_Missense_Mutation_p.G557S	NM_002541	NP_002532	Q02218	ODO1_HUMAN	oxoglutarate dehydrogenase isoform 1 precursor	724					glycolysis|lysine catabolic process|tricarboxylic acid cycle	mitochondrial matrix|mitochondrial membrane	oxoglutarate dehydrogenase (succinyl-transferring) activity|thiamine pyrophosphate binding			upper_aerodigestive_tract(1)|ovary(1)	2					NADH(DB00157)	GTCTGAGTACGGCGTGCTGGG	0.597		NA											12	74					0	0	0	0
STEAP4	79689	broad.mit.edu	37	7	87913465	87913465	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7372-01A-11D-2012-08	TCGA-CR-7372-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9032c525-9bed-47f9-b9f2-ecce4593ea37	067eb6e6-2211-467d-993f-f16368e1da5d	g.chr7:87913465C>A	uc003ujs.2	-	2	225	c.120G>T	c.(118-120)CAG>CAT	p.Q40H	STEAP4_uc010lek.2_Missense_Mutation_p.Q40H|STEAP4_uc003ujt.2_Missense_Mutation_p.Q40H	NM_024636	NP_078912	Q687X5	STEA4_HUMAN	tumor necrosis factor, alpha-induced protein 9	40					fat cell differentiation|ion transport|iron ion homeostasis	Golgi membrane|integral to membrane|plasma membrane	electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|oxidoreductase activity				0	Esophageal squamous(14;0.00802)					AATAACCACACTGGAGCATTT	0.428		NA											9	58					7.48e-07	8.75e-07	1	0
PTPRZ1	5803	broad.mit.edu	37	7	121691548	121691548	+	Nonsense_Mutation	SNP	A	A	T			TCGA-CR-7372-01A-11D-2012-08	TCGA-CR-7372-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9032c525-9bed-47f9-b9f2-ecce4593ea37	067eb6e6-2211-467d-993f-f16368e1da5d	g.chr7:121691548A>T	uc003vjy.2	+	24	6546	c.6151A>T	c.(6151-6153)AAG>TAG	p.K2051*	PTPRZ1_uc003vjz.2_Nonsense_Mutation_p.K1184*|PTPRZ1_uc011knt.1_Nonsense_Mutation_p.K641*	NM_002851	NP_002842	P23471	PTPRZ_HUMAN	protein tyrosine phosphatase, receptor-type,	2051	Cytoplasmic (Potential).|Tyrosine-protein phosphatase 2.				central nervous system development	integral to plasma membrane	protein binding|protein tyrosine/threonine phosphatase activity|transmembrane receptor protein tyrosine phosphatase activity			ovary(3)|large_intestine(2)|lung(2)|central_nervous_system(1)|kidney(1)	9						CAACAGGGAAAAGAATCGAAC	0.348		NA											28	60					0	0	0	0
ZFHX4	79776	broad.mit.edu	37	8	77690483	77690483	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-7372-01A-11D-2012-08	TCGA-CR-7372-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9032c525-9bed-47f9-b9f2-ecce4593ea37	067eb6e6-2211-467d-993f-f16368e1da5d	g.chr8:77690483T>C	uc003yav.2	+	4	3442	c.3055T>C	c.(3055-3057)TGC>CGC	p.C1019R	ZFHX4_uc003yau.1_Missense_Mutation_p.C1045R|ZFHX4_uc003yaw.1_Missense_Mutation_p.C1019R	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	1019						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			TCCCGAATCCTGCTATTACTA	0.488		NA								HNSCC(33;0.089)			21	151					0	0	0	0
PKHD1L1	93035	broad.mit.edu	37	8	110477209	110477209	+	Silent	SNP	G	G	T			TCGA-CR-7372-01A-11D-2012-08	TCGA-CR-7372-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9032c525-9bed-47f9-b9f2-ecce4593ea37	067eb6e6-2211-467d-993f-f16368e1da5d	g.chr8:110477209G>T	uc003yne.2	+	49	8252	c.8148G>T	c.(8146-8148)CTG>CTT	p.L2716L		NM_177531	NP_803875	Q86WI1	PKHL1_HUMAN	fibrocystin L precursor	2716	Extracellular (Potential).				immune response	cytosol|extracellular space|integral to membrane	receptor activity			ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			TTGATGAACTGGGAATGGGGT	0.473		NA								HNSCC(38;0.096)			44	113					8.21e-20	1.03e-19	1	0
CSMD3	114788	broad.mit.edu	37	8	113649178	113649178	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7372-01A-11D-2012-08	TCGA-CR-7372-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9032c525-9bed-47f9-b9f2-ecce4593ea37	067eb6e6-2211-467d-993f-f16368e1da5d	g.chr8:113649178C>T	uc003ynu.2	-	22	3742	c.3583G>A	c.(3583-3585)GGG>AGG	p.G1195R	CSMD3_uc003yns.2_Missense_Mutation_p.G467R|CSMD3_uc003ynt.2_Missense_Mutation_p.G1155R|CSMD3_uc011lhx.1_Missense_Mutation_p.G1091R	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	1195	Sushi 6.|Extracellular (Potential).					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						AAGTTGAACCCGATTCGACTA	0.473		NA								HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			10	60					0	0	0	0
KCNK9	51305	broad.mit.edu	37	8	140630972	140630972	+	Silent	SNP	C	C	T			TCGA-CR-7372-01A-11D-2012-08	TCGA-CR-7372-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9032c525-9bed-47f9-b9f2-ecce4593ea37	067eb6e6-2211-467d-993f-f16368e1da5d	g.chr8:140630972C>T	uc003yvf.1	-	2	718	c.654G>A	c.(652-654)CCG>CCA	p.P218P	KCNK9_uc003yvg.1_Silent_p.P218P|KCNK9_uc003yve.1_RNA	NM_016601	NP_057685	Q9NPC2	KCNK9_HUMAN	potassium channel, subfamily K, member 9	218	Extracellular (Potential).					integral to membrane|membrane fraction	potassium channel activity|voltage-gated ion channel activity			ovary(2)|lung(1)	3	all_cancers(97;3.94e-14)|all_epithelial(106;4.81e-13)|Lung NSC(106;8.18e-05)|all_lung(105;0.00015)|Ovarian(258;0.00235)|Acute lymphoblastic leukemia(118;0.155)	Ovarian(118;0.134)	BRCA - Breast invasive adenocarcinoma(115;0.0855)			CCACGTAGAGCGGCTTCTTCT	0.557		NA											20	99					0	0	0	0
PTPN3	5774	broad.mit.edu	37	9	112200446	112200446	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7372-01A-11D-2012-08	TCGA-CR-7372-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9032c525-9bed-47f9-b9f2-ecce4593ea37	067eb6e6-2211-467d-993f-f16368e1da5d	g.chr9:112200446C>T	uc004bed.2	-	8	647	c.535G>A	c.(535-537)GAT>AAT	p.D179N	PTPN3_uc004beb.2_Missense_Mutation_p.D48N|PTPN3_uc004bec.2_Missense_Mutation_p.D48N|PTPN3_uc010mtu.2_RNA|PTPN3_uc011lwg.1_Missense_Mutation_p.D179N|PTPN3_uc011lwh.1_Missense_Mutation_p.D70N	NM_002829	NP_002820	P26045	PTN3_HUMAN	protein tyrosine phosphatase, non-receptor type	179	FERM.				negative regulation of membrane protein ectodomain proteolysis|negative regulation of mitotic cell cycle	cytoplasm|cytoskeleton|internal side of plasma membrane	ATPase binding|cytoskeletal protein binding|phosphotyrosine binding|protein tyrosine phosphatase activity			ovary(3)	3						TCATTTTGATCGGGTATAAAG	0.433		NA											13	49					0	0	0	0
TTLL11	158135	broad.mit.edu	37	9	124751527	124751527	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7372-01A-11D-2012-08	TCGA-CR-7372-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9032c525-9bed-47f9-b9f2-ecce4593ea37	067eb6e6-2211-467d-993f-f16368e1da5d	g.chr9:124751527C>T	uc004blt.1	-	4	1674	c.1486G>A	c.(1486-1488)GTC>ATC	p.V496I	TTLL11_uc011lyl.1_Missense_Mutation_p.V496I|TTLL11_uc004blr.2_RNA|TTLL11_uc011lym.1_Missense_Mutation_p.V173I|TTLL11_uc004blu.1_3'UTR	NM_194252	NP_919228	Q8NHH1	TTL11_HUMAN	tubulin tyrosine ligase-like family, member 11	496	TTL.				protein modification process	cilium|microtubule basal body	tubulin-tyrosine ligase activity				0						TGGTAGAAGACTTTGAGCTCT	0.562		NA											14	77					0	0	0	0
DMD	1756	broad.mit.edu	37	X	31200900	31200900	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-7372-01A-11D-2012-08	TCGA-CR-7372-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9032c525-9bed-47f9-b9f2-ecce4593ea37	067eb6e6-2211-467d-993f-f16368e1da5d	g.chrX:31200900T>C	uc004dda.1	-	68	10173	c.9929A>G	c.(9928-9930)CAG>CGG	p.Q3310R	DMD_uc004dcq.1_Missense_Mutation_p.Q581R|DMD_uc004dcr.1_Missense_Mutation_p.Q850R|DMD_uc004dcs.1_Missense_Mutation_p.Q850R|DMD_uc004dct.1_Missense_Mutation_p.Q850R|DMD_uc004dcu.1_Missense_Mutation_p.Q850R|DMD_uc004dcv.1_Missense_Mutation_p.Q850R|DMD_uc004dcw.2_Missense_Mutation_p.Q1966R|DMD_uc004dcx.2_Missense_Mutation_p.Q1969R|DMD_uc004dcz.2_Missense_Mutation_p.Q3187R|DMD_uc004dcy.1_Missense_Mutation_p.Q3306R|DMD_uc004ddb.1_Missense_Mutation_p.Q3302R|DMD_uc004dcm.1_Missense_Mutation_p.Q242R|DMD_uc004dcn.1_Missense_Mutation_p.Q242R|DMD_uc004dco.1_Missense_Mutation_p.Q242R|DMD_uc004dcp.1_Missense_Mutation_p.Q242R|DMD_uc011mkb.1_Missense_Mutation_p.Q242R|DMD_uc010ngm.2_Missense_Mutation_p.Q242R	NM_004006	NP_003997	P11532	DMD_HUMAN	dystrophin Dp427m isoform	3310	Interaction with SYNM (By similarity).|ZZ-type.				muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			ovary(3)|pancreas(2)|large_intestine(1)	6		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				ACATTTGGCCTGATGCTTGGC	0.458		NA											3	57					0	0	0	0
PPTC7	160760	broad.mit.edu	37	12	111020740	111020742	+	In_Frame_Del	DEL	CGC	CGC	-			TCGA-CR-7372-01A-11D-2012-08	TCGA-CR-7372-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9032c525-9bed-47f9-b9f2-ecce4593ea37	067eb6e6-2211-467d-993f-f16368e1da5d	g.chr12:111020740_111020742delCGC	uc001trh.1	-	1	323_325	c.95_97delGCG	c.(94-99)GGCGAC>GAC	p.G32del		NM_139283	NP_644812	Q8NI37	PPTC7_HUMAN	T-cell activation protein phosphatase 2C	32	Gly-rich.						metal ion binding|phosphoprotein phosphatase activity				0						AGTCCGTAGTcgccgccgccgcc	0.611		NA											3	4	---	---	---	---	NA	NA	NA	NA
TP53	7157	broad.mit.edu	37	17	7579450	7579451	+	Frame_Shift_Ins	INS	-	-	G			TCGA-CR-7372-01A-11D-2012-08	TCGA-CR-7372-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9032c525-9bed-47f9-b9f2-ecce4593ea37	067eb6e6-2211-467d-993f-f16368e1da5d	g.chr17:7579450_7579451insG	uc002gim.2	-	4	430_431	c.236_237insC	c.(235-237)GCTfs	p.A79fs	TP53_uc002gig.1_Frame_Shift_Ins_p.A79fs|TP53_uc002gih.2_Frame_Shift_Ins_p.A79fs|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_5'Flank|TP53_uc010cng.1_5'Flank|TP53_uc002gii.1_5'Flank|TP53_uc010cnh.1_Frame_Shift_Ins_p.A79fs|TP53_uc010cni.1_Frame_Shift_Ins_p.A79fs|TP53_uc002gij.2_Frame_Shift_Ins_p.A79fs|TP53_uc010cnj.1_5'Flank|TP53_uc002gin.2_Intron|TP53_uc002gio.2_Intron|TP53_uc010vug.1_Frame_Shift_Ins_p.A40fs|TP53_uc010cnk.1_Frame_Shift_Ins_p.A94fs	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	79	Interaction with WWOX.|Interaction with HRMT1L2.		A -> G (in a sporadic cancer; somatic mutation).|A -> T (in a sporadic cancer; somatic mutation).|A -> V (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.0?(7)|p.A76_S90del15(3)|p.G59fs*23(3)|p.V73fs*9(1)|p.R65fs*38(1)|p.D48fs*55(1)|p.A79V(1)|p.A79_A88del10(1)|p.P13fs*18(1)|p.S33fs*23(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CCGGTGTAGGAGCTGCTGGTGC	0.624		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			80	81	---	---	---	---	NA	NA	NA	NA
HIST1H1E	3008	broad.mit.edu	37	6	26156805	26156807	+	In_Frame_Del	DEL	AAG	AAG	-			TCGA-CR-7372-01A-11D-2012-08	TCGA-CR-7372-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9032c525-9bed-47f9-b9f2-ecce4593ea37	067eb6e6-2211-467d-993f-f16368e1da5d	g.chr6:26156805_26156807delAAG	uc003ngq.2	+	1	247_249	c.187_189delAAG	c.(187-189)AAGdel	p.K64del	HIST1H2BD_uc003ngr.2_5'Flank|HIST1H2BD_uc003ngs.2_5'Flank	NM_005321	NP_005312	P10412	H14_HUMAN	histone cluster 1, H1e	64	H15.				nucleosome assembly	nucleosome|nucleus	DNA binding|protein binding			large_intestine(1)|ovary(1)	2						GGCCGCTCTCAAGAAAGCGCTGG	0.616		NA											15	49	---	---	---	---	NA	NA	NA	NA
MTO1	25821	broad.mit.edu	37	6	74176036	74176037	+	Frame_Shift_Ins	INS	-	-	GT			TCGA-CR-7372-01A-11D-2012-08	TCGA-CR-7372-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9032c525-9bed-47f9-b9f2-ecce4593ea37	067eb6e6-2211-467d-993f-f16368e1da5d	g.chr6:74176036_74176037insGT	uc003pgy.3	+	2	446_447	c.322_323insGT	c.(322-324)GGTfs	p.G108fs	MTO1_uc010kav.2_Frame_Shift_Ins_p.G108fs|MTO1_uc003pgz.3_Frame_Shift_Ins_p.G108fs|MTO1_uc003pha.3_5'UTR|MTO1_uc003phb.3_Frame_Shift_Ins_p.G34fs|MTO1_uc003phc.1_Frame_Shift_Ins_p.G34fs	NM_133645	NP_598400	Q9Y2Z2	MTO1_HUMAN	mitochondrial translation optimization 1 homolog	108					tRNA processing	mitochondrion	flavin adenine dinucleotide binding			ovary(3)|skin(2)|pancreas(1)	6						TGACCAGTCTGGTGTACATTAT	0.455		NA											25	86	---	---	---	---	NA	NA	NA	NA
PPP1R3F	89801	broad.mit.edu	37	X	49137917	49137919	+	In_Frame_Del	DEL	TGC	TGC	-			TCGA-CR-7372-01A-11D-2012-08	TCGA-CR-7372-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9032c525-9bed-47f9-b9f2-ecce4593ea37	067eb6e6-2211-467d-993f-f16368e1da5d	g.chrX:49137917_49137919delTGC	uc004dnh.1	+	2	1069_1071	c.1053_1055delTGC	c.(1051-1056)TTTGCC>TTC	p.A352del	PPP1R3F_uc011mnd.1_In_Frame_Del_p.A24del|PPP1R3F_uc004dni.2_In_Frame_Del_p.A7del|PPP1R3F_uc004dnj.1_In_Frame_Del_p.A7del	NM_033215	NP_149992	Q6ZSY5	PPR3F_HUMAN	protein phosphatase 1, regulatory (inhibitor)	352	Extracellular (Potential).					integral to membrane				ovary(2)|skin(1)	3	Ovarian(276;0.236)					ATAACACCTTTGCCATGGGTAAG	0.404		NA											7	10	---	---	---	---	NA	NA	NA	NA