Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	isArtifactMode	oxoGCut
C1orf187	374946	broad.mit.edu	37	1	11775204	11775204	+	Silent	SNP	C	C	G			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr1:11775204C>G	uc001asr.1	+	6	1016	c.876C>G	c.(874-876)CTC>CTG	p.L292L		NM_198545	NP_940947	Q8NBI3	DRAXI_HUMAN	chromosome 1 open reading frame 187 precursor	292					axon guidance|commissural neuron differentiation in spinal cord|dorsal spinal cord development|forebrain development|negative regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	extracellular region					0	Ovarian(185;0.249)	Lung NSC(185;4.15e-05)|all_lung(284;4.76e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00826)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.48e-06)|COAD - Colon adenocarcinoma(227;0.000283)|BRCA - Breast invasive adenocarcinoma(304;0.000316)|Kidney(185;0.000841)|KIRC - Kidney renal clear cell carcinoma(229;0.00269)|STAD - Stomach adenocarcinoma(313;0.00754)|READ - Rectum adenocarcinoma(331;0.0651)		GGGAGCATCTCTGCACACCCC	0.622		NA											19	63					0	0	0	0
EIF4G3	8672	broad.mit.edu	37	1	21268030	21268030	+	Silent	SNP	C	C	T			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr1:21268030C>T	uc001bec.2	-	9	1705	c.1449G>A	c.(1447-1449)GAG>GAA	p.E483E	EIF4G3_uc010odi.1_Silent_p.E87E|EIF4G3_uc010odj.1_Silent_p.E482E|EIF4G3_uc009vpz.2_Intron|EIF4G3_uc001bed.2_Silent_p.E483E|EIF4G3_uc001bef.2_Silent_p.E482E|EIF4G3_uc001bee.2_Silent_p.E489E|EIF4G3_uc001beg.2_Silent_p.E482E|EIF4G3_uc010odk.1_Silent_p.E483E|EIF4G3_uc001beh.2_Silent_p.E494E	NM_003760	NP_003751	O43432	IF4G3_HUMAN	eukaryotic translation initiation factor 4	483					interspecies interaction between organisms|regulation of translational initiation|RNA metabolic process	eukaryotic translation initiation factor 4F complex	protein binding|RNA cap binding|translation initiation factor activity			skin(1)	1		all_lung(284;2.61e-06)|Lung NSC(340;2.81e-06)|Colorectal(325;3.46e-05)|Renal(390;9.67e-05)|Breast(348;0.00149)|Ovarian(437;0.00338)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.023)|COAD - Colon adenocarcinoma(152;5.42e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000327)|GBM - Glioblastoma multiforme(114;0.000696)|Kidney(64;0.0018)|STAD - Stomach adenocarcinoma(196;0.00644)|KIRC - Kidney renal clear cell carcinoma(64;0.0185)|READ - Rectum adenocarcinoma(331;0.124)|Lung(427;0.191)		AATCCAAAATCTCTTCTGTTT	0.433		NA											30	170					0	0	0	0
ZBTB8A	653121	broad.mit.edu	37	1	33065908	33065908	+	Missense_Mutation	SNP	A	A	C	rs147884621	byFrequency	TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr1:33065908A>C	uc001bvn.2	+	5	1699	c.1214A>C	c.(1213-1215)GAG>GCG	p.E405A	ZBTB8A_uc001bvk.2_RNA|ZBTB8A_uc001bvm.2_3'UTR|ZBTB8OS_uc001bvo.1_RNA	NM_001040441	NP_001035531	Q96BR9	ZBT8A_HUMAN	zinc finger and BTB domain containing 8A	405					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						AGTGAAGATGAGAATAGATCC	0.428		NA											5	44					0	0	0	0
CYP4B1	1580	broad.mit.edu	37	1	47282750	47282750	+	Silent	SNP	C	C	G			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr1:47282750C>G	uc001cqm.3	+	9	1185	c.1101C>G	c.(1099-1101)ACC>ACG	p.T367T	CYP4B1_uc001cqn.3_Silent_p.T368T|CYP4B1_uc009vym.2_Silent_p.T353T|CYP4B1_uc010omk.1_Silent_p.T204T	NM_000779	NP_000770	P13584	CP4B1_HUMAN	cytochrome P450, family 4, subfamily B,	367					xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding			ovary(1)|skin(1)	2	Acute lymphoblastic leukemia(166;0.155)					CTTATCTGACCATGTGCATCA	0.547		NA											22	97					0	0	0	0
HFM1	164045	broad.mit.edu	37	1	91817197	91817197	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr1:91817197C>T	uc001doa.3	-	17	2081	c.1981G>A	c.(1981-1983)GAC>AAC	p.D661N	HFM1_uc009wdb.2_Intron|HFM1_uc010osu.1_Missense_Mutation_p.D340N|HFM1_uc010osv.1_Missense_Mutation_p.D345N	NM_001017975	NP_001017975	A2PYH4	HFM1_HUMAN	HFM1 protein	661	Helicase C-terminal.						ATP binding|ATP-dependent helicase activity|nucleic acid binding				0		all_lung(203;0.00961)|Lung NSC(277;0.0351)		all cancers(265;0.000481)|Epithelial(280;0.00863)|OV - Ovarian serous cystadenocarcinoma(397;0.126)|KIRC - Kidney renal clear cell carcinoma(1967;0.171)		GCTGTAGTGTCAAACTGGGGA	0.378		NA											16	65					0	0	0	0
OLFM3	118427	broad.mit.edu	37	1	102290711	102290711	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr1:102290711C>G	uc001duf.2	-	4	594	c.523G>C	c.(523-525)GAG>CAG	p.E175Q	OLFM3_uc001dug.2_Missense_Mutation_p.E155Q|OLFM3_uc001duh.2_RNA|OLFM3_uc001dui.2_RNA|OLFM3_uc001duj.2_Missense_Mutation_p.E80Q|OLFM3_uc001due.2_RNA	NM_058170	NP_477518	Q96PB7	NOE3_HUMAN	olfactomedin 3	175	Potential.					extracellular region				ovary(2)|skin(1)	3		all_epithelial(167;1.87e-06)|all_lung(203;8.12e-05)|Lung NSC(277;0.000189)		all cancers(265;0.0843)|Epithelial(280;0.0921)|COAD - Colon adenocarcinoma(174;0.145)		CTTATTTCCTCCTTGAACTGG	0.458		NA											7	26					0	0	0	0
FLG	2312	broad.mit.edu	37	1	152279707	152279707	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr1:152279707C>T	uc001ezu.1	-	3	7691	c.7655G>A	c.(7654-7656)GGA>GAA	p.G2552E		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	2552	Ser-rich.|Filaggrin 15.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CTCTGATTGTCCCTGGCCCAC	0.592		NA							Ichthyosis				13	330					0	0	0	0
NUP210L	91181	broad.mit.edu	37	1	154018842	154018842	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr1:154018842C>T	uc001fdw.2	-	26	3559	c.3487G>A	c.(3487-3489)GAA>AAA	p.E1163K	NUP210L_uc009woq.2_Missense_Mutation_p.E72K|NUP210L_uc010peh.1_Missense_Mutation_p.E1163K	NM_207308	NP_997191	Q5VU65	P210L_HUMAN	nucleoporin 210kDa-like isoform 1	1163						integral to membrane				skin(5)|ovary(4)|large_intestine(1)|central_nervous_system(1)	11	all_lung(78;9.35e-31)|Lung NSC(65;1.33e-28)|Hepatocellular(266;0.0877)|Melanoma(130;0.128)		LUSC - Lung squamous cell carcinoma(543;0.151)|Colorectal(543;0.198)			ATCTGTACTTCATCCTGCTCA	0.463		NA											7	36					0	0	0	0
GON4L	54856	broad.mit.edu	37	1	155720453	155720453	+	Silent	SNP	A	A	G			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr1:155720453A>G	uc001flz.2	-	32	6745	c.6648T>C	c.(6646-6648)GAT>GAC	p.D2216D	MSTO2P_uc010pgp.1_RNA|GON4L_uc001flx.1_Silent_p.D50D|GON4L_uc009wrg.1_RNA|GON4L_uc001fly.1_Silent_p.D2215D|GON4L_uc009wrh.1_Silent_p.D2215D|GON4L_uc001fma.1_Silent_p.D2216D	NM_001037533	NP_001032622	Q3T8J9	GON4L_HUMAN	gon-4-like isoform a	2216					regulation of transcription, DNA-dependent	cytoplasm|nucleus	DNA binding			ovary(3)	3	Hepatocellular(266;0.0997)|all_hematologic(923;0.145)|all_neural(408;0.195)					TGGTTGCATCATCCTCATCCT	0.512		NA											3	13					0	0	0	0
HSPA6	3310	broad.mit.edu	37	1	161495705	161495705	+	Silent	SNP	C	C	T			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr1:161495705C>T	uc001gap.2	+	2	1917	c.1257C>T	c.(1255-1257)AAC>AAT	p.N419N	HSPA6_uc001gaq.2_Silent_p.N419N	NM_002155	NP_002146	P17066	HSP76_HUMAN	heat shock 70kDa protein 6 (HSP70B')	419					response to unfolded protein		ATP binding			skin(1)	1	all_cancers(52;4.89e-16)|all_hematologic(112;0.0207)		BRCA - Breast invasive adenocarcinoma(70;0.00376)			TCCAGAGGAACGCCACTATCC	0.582		NA											4	33					0	0	0	0
UCK2	7371	broad.mit.edu	37	1	165877020	165877020	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr1:165877020G>A	uc001gdp.2	+	7	927	c.746G>A	c.(745-747)CGC>CAC	p.R249H	UCK2_uc010plb.1_Missense_Mutation_p.R111H	NM_012474	NP_036606	Q9BZX2	UCK2_HUMAN	uridine-cytidine kinase 2	249					pyrimidine base metabolic process|pyrimidine nucleoside salvage	cytosol	ATP binding|phosphotransferase activity, alcohol group as acceptor|uridine kinase activity			ovary(1)	1	all_hematologic(923;0.048)|Acute lymphoblastic leukemia(8;0.155)					ACCCCTTCACGCAAGAGGCAG	0.612		NA											22	87					0	0	0	0
DCAF6	55827	broad.mit.edu	37	1	168037616	168037616	+	Silent	SNP	C	C	T			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr1:168037616C>T	uc001gew.2	+	18	2675	c.2433C>T	c.(2431-2433)CTC>CTT	p.L811L	DCAF6_uc001gev.2_Silent_p.L831L|DCAF6_uc001gex.2_Silent_p.L902L|DCAF6_uc010plk.1_Silent_p.L871L|DCAF6_uc001gey.2_Silent_p.L684L|DCAF6_uc001gez.2_Silent_p.L114L	NM_001017977	NP_001017977	Q58WW2	DCAF6_HUMAN	IQ motif and WD repeats 1 isoform b	811					positive regulation of transcription from RNA polymerase II promoter	CUL4 RING ubiquitin ligase complex|nucleus	ligand-dependent nuclear receptor transcription coactivator activity			ovary(1)|central_nervous_system(1)|skin(1)	3						GAAACGAACTCATGCTGGAAG	0.373		NA											9	49					0	0	0	0
XCL2	6846	broad.mit.edu	37	1	168511261	168511261	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr1:168511261G>C	uc001gfn.3	-	2	179	c.146C>G	c.(145-147)ACC>AGC	p.T49S		NM_003175	NP_003166	Q9UBD3	XCL2_HUMAN	chemokine (C motif) ligand 2 precursor	49					blood circulation|chemotaxis|immune response|signal transduction	extracellular space	chemokine activity			ovary(1)	1	all_hematologic(923;0.215)					TTCCGTGATGGTGTAGGTCTT	0.488		NA											4	45					0	0	0	0
XCL1	6375	broad.mit.edu	37	1	168549385	168549385	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr1:168549385C>G	uc001gfo.1	+	2	166	c.146C>G	c.(145-147)ACC>AGC	p.T49S		NM_002995	NP_002986	P47992	XCL1_HUMAN	chemokine (C motif) ligand 1	49					CD4-positive, alpha-beta T cell proliferation|CD8-positive, alpha-beta T cell proliferation|cell-cell signaling|cellular response to interleukin-4|cellular response to transforming growth factor beta stimulus|immunoglobulin production in mucosal tissue|lymphocyte chemotaxis|negative regulation of interferon-gamma production|negative regulation of interleukin-2 production|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of T cell cytokine production|negative regulation of T-helper 1 cell activation|negative regulation of transcription, DNA-dependent|neutrophil chemotaxis|positive regulation of activated T cell proliferation|positive regulation of B cell chemotaxis|positive regulation of granzyme A production|positive regulation of granzyme B production|positive regulation of interleukin-10 production|positive regulation of natural killer cell chemotaxis|positive regulation of neutrophil chemotaxis|positive regulation of release of sequestered calcium ion into cytosol|positive regulation of T cell chemotaxis|positive regulation of T cell cytokine production|positive regulation of T cell mediated cytotoxicity|positive regulation of thymocyte migration|positive regulation of transforming growth factor-beta production|regulation of inflammatory response|release of sequestered calcium ion into cytosol|response to virus|T-helper 1 cell cytokine production|T-helper 2 cell cytokine production	extracellular space	chemokine activity|protein homodimerization activity				0	all_hematologic(923;0.208)					AAGACCTACACCATCACGGAA	0.483		NA											12	102					0	0	0	0
FAM20B	9917	broad.mit.edu	37	1	179013306	179013306	+	Silent	SNP	G	G	A			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr1:179013306G>A	uc001gmc.2	+	2	617	c.324G>A	c.(322-324)CTG>CTA	p.L108L		NM_014864	NP_055679	O75063	XYLK_HUMAN	hypothetical protein LOC9917 precursor	108	Lumenal (Potential).					Golgi membrane|integral to membrane	ATP binding|kinase activity|phosphotransferase activity, alcohol group as acceptor			ovary(3)	3						GGACACAGCTGAAAGCCTTAC	0.448		NA											8	51					0	0	0	0
NCF2	4688	broad.mit.edu	37	1	183529328	183529328	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr1:183529328C>G	uc001gqj.3	-	14	1646	c.1371G>C	c.(1369-1371)AAG>AAC	p.K457N	NCF2_uc010pod.1_Missense_Mutation_p.K412N|NCF2_uc010poe.1_Missense_Mutation_p.K376N|NCF2_uc001gqk.3_Missense_Mutation_p.K457N	NM_000433	NP_000424	P19878	NCF2_HUMAN	neutrophil cytosolic factor 2	457	SH3 2.				cellular defense response|innate immune response|respiratory burst|superoxide anion generation	NADPH oxidase complex|nucleolus	electron carrier activity|protein C-terminus binding			ovary(3)	3						GGCTGCCTTTCTTAAGCTGAG	0.463		NA											7	167					0	0	0	0
CNST	163882	broad.mit.edu	37	1	246810955	246810956	+	Nonsense_Mutation	DNP	GC	GC	CT			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr1:246810955_246810956GC>CT	uc001ibp.2	+	9	1830_1831	c.1452_1453GC>CT	c.(1450-1455)CTGCAG>CTCTAG	p.Q485*	CNST_uc001ibo.3_Nonsense_Mutation_p.Q485*	NM_152609	NP_689822	Q6PJW8	CNST_HUMAN	hypothetical protein LOC163882 isoform 1	485					positive regulation of Golgi to plasma membrane protein transport	integral to membrane|plasma membrane|protein complex|trans-Golgi network|transport vesicle	connexin binding				0						TAAATGAGCTGCAGCAGCCTGA	0.465		NA											15	80					0	0	0	0
OR2G2	81470	broad.mit.edu	37	1	247752501	247752501	+	Silent	SNP	C	C	T			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr1:247752501C>T	uc010pyy.1	+	1	840	c.840C>T	c.(838-840)TTC>TTT	p.F280F		NM_001001915	NP_001001915	Q8NGZ5	OR2G2_HUMAN	olfactory receptor, family 2, subfamily G,	280	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.017)			TTTCTCTCTTCTACACTGTGG	0.363		NA											12	152					0	0	0	0
GTPBP4	23560	broad.mit.edu	37	10	1042133	1042133	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr10:1042133G>A	uc001ift.2	+	4	482	c.411G>A	c.(409-411)ATG>ATA	p.M137I	GTPBP4_uc010qac.1_Translation_Start_Site|GTPBP4_uc001ifu.2_RNA|GTPBP4_uc010qad.1_Missense_Mutation_p.M21I|GTPBP4_uc010qae.1_Missense_Mutation_p.M90I	NM_012341	NP_036473	Q9BZE4	NOG1_HUMAN	G protein-binding protein CRFG	137					negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of cell-cell adhesion|negative regulation of collagen binding|negative regulation of DNA replication|negative regulation of protein ubiquitination|protein stabilization|regulation of cyclin-dependent protein kinase activity|ribosome biogenesis	nucleolus|perinuclear region of cytoplasm	GTP binding|GTPase activity|protein binding			ovary(1)|skin(1)	2		all_epithelial(10;0.107)|Colorectal(49;0.14)	OV - Ovarian serous cystadenocarcinoma(33;0.0814)	Epithelial(11;0.0513)|all cancers(11;0.135)|OV - Ovarian serous cystadenocarcinoma(14;0.173)		TGGGACGGATGTGCACAGTGA	0.512		NA											3	17					0	0	0	0
EPC1	80314	broad.mit.edu	37	10	32582604	32582604	+	Silent	SNP	C	C	T			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr10:32582604C>T	uc001iwg.1	-	3	645	c.375G>A	c.(373-375)GTG>GTA	p.V125V	EPC1_uc001iwi.3_Silent_p.V75V|EPC1_uc009xlt.2_Silent_p.V75V|EPC1_uc001iwh.1_Silent_p.V125V	NM_025209	NP_079485	Q9H2F5	EPC1_HUMAN	enhancer of polycomb 1	125					histone H2A acetylation|histone H4 acetylation|negative regulation of gene expression, epigenetic|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|regulation of growth|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nuclear membrane|Piccolo NuA4 histone acetyltransferase complex				ovary(3)|central_nervous_system(1)	4		Prostate(175;0.0199)				TCAGTTTATTCACAAATACTT	0.383		NA											8	36					0	0	0	0
ANKRD30A	91074	broad.mit.edu	37	10	37421251	37421251	+	Silent	SNP	G	G	C			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr10:37421251G>C	uc001iza.1	+	4	525	c.426G>C	c.(424-426)GCG>GCC	p.A142A		NM_052997	NP_443723	Q9BXX3	AN30A_HUMAN	ankyrin repeat domain 30A	198	ANK 4.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(7)|breast(1)|skin(1)	9						ATGCAAATGCGAATGCAGTTA	0.299		NA											6	76					0	0	0	0
AIFM2	84883	broad.mit.edu	37	10	71874076	71874076	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr10:71874076G>A	uc010qjg.1	-	8	993	c.980C>T	c.(979-981)ACG>ATG	p.T327M	AIFM2_uc001jqp.1_Missense_Mutation_p.T327M	NM_032797	NP_116186	Q9BRQ8	AIFM2_HUMAN	apoptosis-inducing factor (AIF)-like	327					apoptotic mitochondrial changes|chromosome condensation|induction of apoptosis	cytosol|integral to membrane|mitochondrial outer membrane	DNA binding|electron-transferring-flavoprotein dehydrogenase activity|flavin adenine dinucleotide binding			central_nervous_system(1)	1						CAGGAGGAACGTCAGTGCACC	0.592		NA											12	39					0	0	0	0
ARHGAP19	84986	broad.mit.edu	37	10	99025873	99025873	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr10:99025873G>C	uc001knb.2	-	2	95	c.66C>G	c.(64-66)ATC>ATG	p.I22M	ARHGAP19_uc001kmy.2_RNA|ARHGAP19_uc001kna.2_Missense_Mutation_p.I13M|ARHGAP19_uc009xvi.2_RNA|ARHGAP19_uc009xvj.2_Missense_Mutation_p.I22M|ARHGAP19_uc009xvk.2_Intron	NM_032900	NP_116289	Q14CB8	RHG19_HUMAN	Rho GTPase activating protein 19	22					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|nucleus	GTPase activator activity				0		Colorectal(252;0.0854)		Epithelial(162;7.65e-09)|all cancers(201;4.49e-07)		CAAAACTGCAGATGGCATCAC	0.408		NA											12	57					0	0	0	0
NOLC1	9221	broad.mit.edu	37	10	103912186	103912186	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr10:103912186C>T	uc001kuo.2	+	1	254	c.19C>T	c.(19-21)CGC>TGC	p.R7C	NOLC1_uc001kup.2_Missense_Mutation_p.R7C|NOLC1_uc001kuq.2_Missense_Mutation_p.R7C|NOLC1_uc009xxb.1_5'UTR|NOLC1_uc001kur.2_5'UTR	NM_004741	NP_004732	Q14978	NOLC1_HUMAN	nucleolar and coiled-body phosphoprotein 1	7					mitosis|rRNA processing	cytoplasm|nucleolus	ATP binding|GTP binding|protein binding			ovary(1)	1		Colorectal(252;0.122)		Epithelial(162;5.19e-08)|all cancers(201;9.43e-07)		CGCCGGCATTCGCCGCGTGGT	0.622		NA											12	72					0	0	0	0
C11orf35	256329	broad.mit.edu	37	11	557988	557988	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr11:557988C>G	uc001lpx.2	-	5	514	c.451G>C	c.(451-453)GAG>CAG	p.E151Q	uc001lpy.2_RNA|uc001lpz.2_5'Flank|RASSF7_uc001lqa.2_5'Flank|RASSF7_uc001lqb.2_5'Flank	NM_173573	NP_775844	Q8IXW0	CK035_HUMAN	hypothetical protein LOC256329	151	Potential.									pancreas(1)	1		all_cancers(49;2.16e-06)|all_epithelial(84;0.000256)|Breast(177;0.00122)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;7.18e-28)|Epithelial(43;6.93e-27)|OV - Ovarian serous cystadenocarcinoma(40;6.97e-21)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0375)|LUSC - Lung squamous cell carcinoma(625;0.0703)		GCCTCCATCTCCTGGAGCGTG	0.657		NA											11	25					0	0	0	0
C11orf35	256329	broad.mit.edu	37	11	558188	558188	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr11:558188C>G	uc001lpx.2	-	4	435	c.372G>C	c.(370-372)TTG>TTC	p.L124F	uc001lpy.2_RNA|uc001lpz.2_5'Flank|RASSF7_uc001lqa.2_5'Flank|RASSF7_uc001lqb.2_5'Flank	NM_173573	NP_775844	Q8IXW0	CK035_HUMAN	hypothetical protein LOC256329	124	Potential.									pancreas(1)	1		all_cancers(49;2.16e-06)|all_epithelial(84;0.000256)|Breast(177;0.00122)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;7.18e-28)|Epithelial(43;6.93e-27)|OV - Ovarian serous cystadenocarcinoma(40;6.97e-21)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0375)|LUSC - Lung squamous cell carcinoma(625;0.0703)		TCTGTTCCTTCAACTCCTGGA	0.652		NA											7	26					0	0	0	0
OR51A2	401667	broad.mit.edu	37	11	4976057	4976057	+	Missense_Mutation	SNP	T	T	G			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr11:4976057T>G	uc010qyt.1	-	1	887	c.887A>C	c.(886-888)AAA>ACA	p.K296T		NM_001004748	NP_001004748	Q8NGJ7	O51A2_HUMAN	olfactory receptor, family 51, subfamily A,	296	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;3.22e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0284)|LUSC - Lung squamous cell carcinoma(625;0.19)		CTGTTTAGTTTTTACACAATA	0.388		NA											6	73					0	0	0	0
OR51A2	401667	broad.mit.edu	37	11	4976440	4976440	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr11:4976440C>G	uc010qyt.1	-	1	504	c.504G>C	c.(502-504)TTG>TTC	p.L168F		NM_001004748	NP_001004748	Q8NGJ7	O51A2_HUMAN	olfactory receptor, family 51, subfamily A,	168	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;3.22e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0284)|LUSC - Lung squamous cell carcinoma(625;0.19)		TGCAATATCTCAAGCTTCTTA	0.423		NA											41	211					0	0	0	0
OR4D6	219983	broad.mit.edu	37	11	59224497	59224497	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr11:59224497G>A	uc010rku.1	+	1	64	c.64G>A	c.(64-66)GAG>AAG	p.E22K		NM_001004708	NP_001004708	Q8NGJ1	OR4D6_HUMAN	olfactory receptor, family 4, subfamily D,	22	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						ACGTTCCCGAGAGCTGGAGTT	0.468		NA											6	112					0	0	0	0
TPCN2	219931	broad.mit.edu	37	11	68822767	68822767	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr11:68822767G>A	uc001oos.2	+	4	492	c.376G>A	c.(376-378)GAG>AAG	p.E126K	TPCN2_uc009ysk.1_RNA|TPCN2_uc001oor.2_Intron|TPCN2_uc010rqg.1_Missense_Mutation_p.E126K	NM_139075	NP_620714	Q8NHX9	TPC2_HUMAN	two pore segment channel 2	126	Extracellular (Potential).				cellular calcium ion homeostasis|smooth muscle contraction	endosome membrane|integral to membrane|lysosomal membrane	NAADP-sensitive calcium-release channel activity|voltage-gated calcium channel activity				0			STAD - Stomach adenocarcinoma(18;0.0208)|LUAD - Lung adenocarcinoma(13;0.0713)			CGGCCTGACCGAGAGTGTCGA	0.672		NA											15	59					0	0	0	0
SHANK2	22941	broad.mit.edu	37	11	70331427	70331427	+	Silent	SNP	G	G	A			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr11:70331427G>A	uc001oqc.2	-	21	5049	c.4971C>T	c.(4969-4971)CTC>CTT	p.L1657L	SHANK2_uc010rqn.1_Silent_p.L1069L|SHANK2_uc001opz.2_Silent_p.L1062L|uc009ysn.1_Intron|SHANK2_uc001opy.2_Intron	NM_012309	NP_036441	Q9UPX8	SHAN2_HUMAN	SH3 and multiple ankyrin repeat domains 2	1278					intracellular signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	GKAP/Homer scaffold activity|ionotropic glutamate receptor binding|SH3 domain binding			ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	5			LUSC - Lung squamous cell carcinoma(11;4.72e-09)|STAD - Stomach adenocarcinoma(18;0.071)			ACCTTGGAGCGAGGCTGGCGG	0.577		NA											10	47					0	0	0	0
KRTAP5-8	57830	broad.mit.edu	37	11	71249246	71249246	+	Missense_Mutation	SNP	A	A	C			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr11:71249246A>C	uc001oqr.1	+	1	176	c.145A>C	c.(145-147)AGC>CGC	p.S49R		NM_021046	NP_066384	O75690	KRA58_HUMAN	keratin associated protein 5-8	49	9 X 4 AA repeats of C-C-X-P.					extracellular region|keratin filament	structural constituent of epidermis				0						TTCCTGCTCCAGCTGTGGCTC	0.682		NA											14	321					0	0	0	0
MAP6	4135	broad.mit.edu	37	11	75316987	75316987	+	Silent	SNP	C	C	T	rs139425764	byFrequency	TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr11:75316987C>T	uc001owu.2	-	3	1247	c.1182G>A	c.(1180-1182)ACG>ACA	p.T394T	MAP6_uc001owv.2_Silent_p.T394T	NM_033063	NP_149052	Q96JE9	MAP6_HUMAN	microtubule-associated protein 6 isoform 1	394	Calmodulin-binding (By similarity).					Golgi apparatus|microtubule|perinuclear region of cytoplasm	calmodulin binding				0	Ovarian(111;0.11)					TGGCCTTCCTCGTGGGCTTAT	0.532		NA											14	40					0	0	0	0
LRP6	4040	broad.mit.edu	37	12	12284974	12284974	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr12:12284974G>A	uc001rah.3	-	18	3893	c.3751C>T	c.(3751-3753)CCT>TCT	p.P1251S	BCL2L14_uc001raf.1_Intron|LRP6_uc010shl.1_Intron	NM_002336	NP_002327	O75581	LRP6_HUMAN	low density lipoprotein receptor-related protein	1251	Extracellular (Potential).|LDL-receptor class A 1.				cellular response to cholesterol|negative regulation of protein phosphorylation|negative regulation of protein serine/threonine kinase activity|negative regulation of smooth muscle cell apoptosis|neural crest formation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell cycle|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway involved in dorsal/ventral axis specification|Wnt receptor signaling pathway involved in dorsal/ventral axis specification	cell surface|cytoplasmic vesicle|endoplasmic reticulum|integral to membrane|plasma membrane	coreceptor activity|frizzled binding|kinase inhibitor activity|low-density lipoprotein receptor activity|protein homodimerization activity|toxin transporter activity|Wnt-protein binding			lung(4)|skin(4)|ovary(2)|kidney(1)|central_nervous_system(1)	12		Prostate(47;0.0865)				AACTGCTGAGGAGAACATGTT	0.453		NA											5	74					0	0	0	0
EPS8	2059	broad.mit.edu	37	12	15800065	15800065	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr12:15800065C>T	uc009zif.2	-	15	1658	c.1564G>A	c.(1564-1566)GAT>AAT	p.D522N	EPS8_uc001rdb.2_Missense_Mutation_p.D522N|EPS8_uc009zig.2_Missense_Mutation_p.D262N|EPS8_uc010shv.1_Missense_Mutation_p.D262N	NM_004447	NP_004438	Q12929	EPS8_HUMAN	epidermal growth factor receptor pathway	522					cell proliferation|epidermal growth factor receptor signaling pathway		SH3/SH2 adaptor activity			ovary(2)|upper_aerodigestive_tract(1)|skin(1)	4		all_epithelial(100;1.87e-05)|Breast(259;0.000286)|Hepatocellular(102;0.244)		BRCA - Breast invasive adenocarcinoma(232;4.29e-05)|GBM - Glioblastoma multiforme(207;0.0264)		TGTTACCTATCTATATGGCGA	0.448		NA											7	74					0	0	0	0
SLCO1C1	53919	broad.mit.edu	37	12	20890094	20890094	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr12:20890094G>C	uc001rej.3	+	12	1791	c.1436G>C	c.(1435-1437)AGA>ACA	p.R479T	SLCO1C1_uc010sii.1_Missense_Mutation_p.R479T|SLCO1C1_uc010sij.1_Missense_Mutation_p.R430T|SLCO1C1_uc009zip.2_Missense_Mutation_p.R313T|SLCO1C1_uc001rei.2_Missense_Mutation_p.R479T|SLCO1C1_uc010sik.1_Missense_Mutation_p.R361T	NM_017435	NP_059131	Q9NYB5	SO1C1_HUMAN	solute carrier organic anion transporter family,	479	Extracellular (Potential).|Kazal-like.				sodium-independent organic anion transport	integral to membrane|plasma membrane	thyroid hormone transmembrane transporter activity			ovary(5)|pancreas(1)|skin(1)	7	Esophageal squamous(101;0.149)					TGCAACTCAAGATGCAAATGT	0.388		NA											3	37					0	0	0	0
SYT10	341359	broad.mit.edu	37	12	33532834	33532834	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr12:33532834C>T	uc001rll.1	-	6	1730	c.1433G>A	c.(1432-1434)CGA>CAA	p.R478Q	SYT10_uc009zju.1_Missense_Mutation_p.R288Q	NM_198992	NP_945343	Q6XYQ8	SYT10_HUMAN	synaptotagmin X	478	Cytoplasmic (Potential).					cell junction|integral to membrane|synaptic vesicle membrane	metal ion binding|transporter activity			ovary(1)|skin(1)	2	Lung NSC(5;8.37e-07)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0334)					CCAGTGGTCTCGCCCAAGACC	0.458		NA											22	89					0	0	0	0
NCKAP5L	57701	broad.mit.edu	37	12	50186313	50186313	+	Silent	SNP	G	G	A			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr12:50186313G>A	uc009zlk.2	-	12	3910	c.3708C>T	c.(3706-3708)TTC>TTT	p.F1236F	NCKAP5L_uc001rvc.3_Silent_p.F440F|NCKAP5L_uc001rvb.2_Silent_p.F829F	NM_001037806	NP_001032895	Q9HCH0	NCK5L_HUMAN	NCK-associated protein 5-like	1232	Pro-rich.									central_nervous_system(1)	1						TAGTATTGGGGAAGGTCCAGT	0.632		NA											5	46					0	0	0	0
CMKLR1	1240	broad.mit.edu	37	12	108686010	108686010	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr12:108686010C>T	uc009zuw.2	-	3	921	c.730G>A	c.(730-732)GTG>ATG	p.V244M	CMKLR1_uc001tmw.2_Missense_Mutation_p.V244M|CMKLR1_uc001tmv.2_Missense_Mutation_p.V242M|CMKLR1_uc009zuv.2_Missense_Mutation_p.V244M	NM_001142345	NP_001135817	Q99788	CML1_HUMAN	chemokine-like receptor 1 isoform a	244	Helical; Name=5; (Potential).				chemotaxis|immune response|negative regulation of interleukin-12 production|negative regulation of NF-kappaB transcription factor activity|positive regulation of macrophage chemotaxis|regulation of calcium-mediated signaling|skeletal system development	integral to plasma membrane	chemokine receptor activity			lung(3)|ovary(1)|pancreas(1)	5						AGTTTGCACACGATGGTGAGG	0.557		NA											4	38					0	0	0	0
KSR2	283455	broad.mit.edu	37	12	117977627	117977627	+	Silent	SNP	C	C	T			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr12:117977627C>T	uc001two.2	-	10	1552	c.1497G>A	c.(1495-1497)ACG>ACA	p.T499T		NM_173598	NP_775869	Q6VAB6	KSR2_HUMAN	kinase suppressor of ras 2	528	Pro-rich.				intracellular signal transduction	cytoplasm|membrane	ATP binding|metal ion binding|protein serine/threonine kinase activity			lung(10)|central_nervous_system(2)|stomach(1)|large_intestine(1)|breast(1)	15	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					GCGAGGAGGGCGTGGAGGACG	0.632		NA											11	34					0	0	0	0
DNAH10	196385	broad.mit.edu	37	12	124330339	124330339	+	Silent	SNP	C	C	T			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr12:124330339C>T	uc001uft.3	+	30	5224	c.5199C>T	c.(5197-5199)AAC>AAT	p.N1733N		NM_207437	NP_997320	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	1733	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(3)|skin(2)|central_nervous_system(1)	6	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		TAAGCAAAAACGACAGGAAAA	0.473		NA											6	75					0	0	0	0
DDX51	317781	broad.mit.edu	37	12	132626474	132626474	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr12:132626474C>T	uc001ujy.3	-	6	955	c.916G>A	c.(916-918)GAT>AAT	p.D306N	NOC4L_uc001ujz.1_5'Flank	NM_175066	NP_778236	Q8N8A6	DDX51_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 51	306	Helicase ATP-binding.				rRNA processing	nucleolus	ATP binding|ATP-dependent helicase activity|RNA binding			lung(1)|pancreas(1)	2	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.241)		OV - Ovarian serous cystadenocarcinoma(86;7.59e-08)|Epithelial(86;3.62e-07)|all cancers(50;2.13e-05)		GGTGTGGCATCTGTGTAGATG	0.547		NA											4	34					0	0	0	0
FRY	10129	broad.mit.edu	37	13	32757152	32757152	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr13:32757152C>G	uc001utx.2	+	24	3531	c.3035C>G	c.(3034-3036)GCT>GGT	p.A1012G	FRY_uc010tdw.1_RNA	NM_023037	NP_075463	Q5TBA9	FRY_HUMAN	furry homolog	1012					regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to membrane				ovary(5)|large_intestine(1)|skin(1)	7		Lung SC(185;0.0271)		all cancers(112;4.81e-05)|Epithelial(112;0.000656)|OV - Ovarian serous cystadenocarcinoma(117;0.0123)|BRCA - Breast invasive adenocarcinoma(63;0.0295)|GBM - Glioblastoma multiforme(144;0.104)		ATGAAAGAAGCTCTGGAAAGA	0.323		NA											32	34					0	0	0	0
TRPC4	7223	broad.mit.edu	37	13	38320194	38320194	+	Silent	SNP	C	C	T	rs115609911	by1000genomes	TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr13:38320194C>T	uc001uws.2	-	3	1012	c.777G>A	c.(775-777)ACG>ACA	p.T259T	TRPC4_uc010abv.2_5'UTR|TRPC4_uc001uwt.2_Silent_p.T259T|TRPC4_uc010tey.1_Silent_p.T259T|TRPC4_uc010abw.2_Intron|TRPC4_uc010abx.2_Silent_p.T259T|TRPC4_uc010aby.2_Silent_p.T259T	NM_016179	NP_057263	Q9UBN4	TRPC4_HUMAN	transient receptor potential cation channel,	259	Potential.|Cytoplasmic (Potential).|Multimerization domain (By similarity).				axon guidance|calcium ion import	basolateral plasma membrane|calcium channel complex|cell surface|cortical cytoskeleton	beta-catenin binding|cadherin binding|store-operated calcium channel activity			ovary(3)|skin(2)|breast(1)	6				all cancers(112;1.92e-08)|Epithelial(112;5.04e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000677)|GBM - Glioblastoma multiforme(144;0.00623)|BRCA - Breast invasive adenocarcinoma(63;0.0126)		TGGAACTTCTCGTCTGATCCA	0.408		NA											11	115					0	0	0	0
COL4A1	1282	broad.mit.edu	37	13	110827073	110827073	+	Silent	SNP	G	G	A			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr13:110827073G>A	uc001vqw.3	-	38	3344	c.3222C>T	c.(3220-3222)TTC>TTT	p.F1074F	COL4A1_uc010agl.2_Intron	NM_001845	NP_001836	P02462	CO4A1_HUMAN	alpha 1 type IV collagen preproprotein	1074	Triple-helical region.				angiogenesis|axon guidance		extracellular matrix structural constituent|platelet-derived growth factor binding			ovary(3)|lung(1)|central_nervous_system(1)|pancreas(1)	6	all_cancers(4;9.8e-13)|all_epithelial(4;9.66e-08)|all_lung(23;3.75e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00178)|all_neural(89;0.00459)|Medulloblastoma(90;0.00596)|Lung SC(71;0.0604)	Breast(118;0.2)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.145)			GGCTTCCTGGGAAACCCGCTA	0.498		NA											16	180					0	0	0	0
TFDP1	7027	broad.mit.edu	37	13	114290326	114290326	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr13:114290326G>A	uc001vtw.2	+	9	934	c.722G>A	c.(721-723)CGG>CAG	p.R241Q	TFDP1_uc010tkd.1_Missense_Mutation_p.R146Q|TFDP1_uc010tke.1_Missense_Mutation_p.R146Q|TFDP1_uc001vty.3_Missense_Mutation_p.R241Q|TFDP1_uc001vtx.2_Missense_Mutation_p.R121Q	NM_007111	NP_009042	Q14186	TFDP1_HUMAN	transcription factor Dp-1	241	Dimerization (Potential).|Enhances binding of RB protein to E2F.|DCB1.				cell proliferation|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|regulation of transcription from RNA polymerase II promoter	transcription factor complex	DNA binding|protein domain specific binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription factor binding			lung(4)|ovary(2)|skin(1)	7	Lung NSC(43;0.0113)|all_neural(89;0.0337)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.132)|all_epithelial(44;0.0731)|all_lung(25;0.149)|Breast(118;0.153)	all cancers(43;0.0576)			CAGAGAAACCGGCATGCGGAG	0.587		NA								TSP Lung(29;0.18)			9	70					0	0	0	0
PTGER2	5732	broad.mit.edu	37	14	52794009	52794009	+	Nonsense_Mutation	SNP	C	C	G			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr14:52794009C>G	uc001wzr.2	+	2	1165	c.914C>G	c.(913-915)TCA>TGA	p.S305*		NM_000956	NP_000947	P43116	PE2R2_HUMAN	prostaglandin E receptor 2 (subtype EP2), 53kDa	305	Helical; Name=7; (Potential).					integral to plasma membrane	prostaglandin E receptor activity			lung(1)|breast(1)	2	Breast(41;0.0639)|all_epithelial(31;0.0729)				Alprostadil(DB00770)|Iloprost(DB01088)	AGGTTTTTATCAATTAATTCA	0.388		NA											13	47					0	0	0	0
SYNE2	23224	broad.mit.edu	37	14	64691756	64691756	+	Missense_Mutation	SNP	G	G	A	rs146398606	byFrequency	TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr14:64691756G>A	uc001xgm.2	+	114	20673	c.20443G>A	c.(20443-20445)GAG>AAG	p.E6815K	SYNE2_uc001xgl.2_Missense_Mutation_p.E6837K|SYNE2_uc010apy.2_Missense_Mutation_p.E3200K|SYNE2_uc001xgn.2_Missense_Mutation_p.E1776K|SYNE2_uc001xgo.2_RNA|SYNE2_uc010aqa.2_Missense_Mutation_p.E785K|SYNE2_uc001xgq.2_Missense_Mutation_p.E1194K|SYNE2_uc001xgr.2_Missense_Mutation_p.E598K|SYNE2_uc010tsi.1_Missense_Mutation_p.E472K|SYNE2_uc001xgs.2_Missense_Mutation_p.E486K|SYNE2_uc001xgt.2_Missense_Mutation_p.E359K	NM_015180	NP_055995	Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	6815	Cytoplasmic (Potential).				centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			ovary(8)|breast(4)|central_nervous_system(1)|pancreas(1)	14				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		GGAGGAGACAGAGAGCAGGTA	0.488		NA											7	22					0	0	0	0
GTF2A1	2957	broad.mit.edu	37	14	81659171	81659171	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr14:81659171G>A	uc001xvf.1	-	7	1057	c.625C>T	c.(625-627)CTT>TTT	p.L209F	GTF2A1_uc010atb.1_Missense_Mutation_p.L159F|GTF2A1_uc001xvg.1_Missense_Mutation_p.L170F	NM_015859	NP_056943	P52655	TF2AA_HUMAN	TFIIA alpha, p55 isoform 1	209					regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	cytoplasm|transcription factor TFIIA complex	DNA binding|protein binding|protein heterodimerization activity|TBP-class protein binding|transcription coactivator activity			breast(1)	1				BRCA - Breast invasive adenocarcinoma(234;0.0287)		CCTCCAGGAAGAGGAGCCAGC	0.413		NA											7	137					0	0	0	0
KCNK13	56659	broad.mit.edu	37	14	90650623	90650623	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr14:90650623G>A	uc001xye.1	+	2	945	c.503G>A	c.(502-504)CGA>CAA	p.R168Q		NM_022054	NP_071337	Q9HB14	KCNKD_HUMAN	potassium channel, subfamily K, member 13	168	Cytoplasmic (Potential).					integral to membrane	potassium channel activity|voltage-gated ion channel activity			skin(1)	1		all_cancers(154;0.186)				CTCCGGAGACGAGGGGCCCTG	0.607		NA											22	77					0	0	0	0
CHGA	1113	broad.mit.edu	37	14	93397717	93397717	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr14:93397717G>A	uc001ybc.3	+	6	738	c.478G>A	c.(478-480)GAG>AAG	p.E160K	CHGA_uc010aum.2_RNA|CHGA_uc001ybd.3_Intron	NM_001275	NP_001266	P10645	CMGA_HUMAN	chromogranin A precursor	160					regulation of blood pressure	extracellular region|stored secretory granule				skin(2)	2		all_cancers(154;0.0843)		Epithelial(152;0.102)|COAD - Colon adenocarcinoma(157;0.208)|all cancers(159;0.224)		GCCCATGCAGGAGTCCAAGGC	0.532		NA											4	20					0	0	0	0
ACSBG1	23205	broad.mit.edu	37	15	78465941	78465941	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr15:78465941C>G	uc002bdh.2	-	13	2139	c.2083G>C	c.(2083-2085)GAG>CAG	p.E695Q	ACSBG1_uc010umw.1_Missense_Mutation_p.E691Q|ACSBG1_uc010umx.1_Missense_Mutation_p.E453Q	NM_015162	NP_055977	Q96GR2	ACBG1_HUMAN	lipidosin	695					long-chain fatty acid metabolic process|myelination|very long-chain fatty acid metabolic process	cytoplasmic membrane-bounded vesicle|endoplasmic reticulum|microsome	ATP binding|long-chain fatty acid-CoA ligase activity|very long-chain fatty acid-CoA ligase activity			ovary(1)	1						CTACCCAACTCTCCACCCGAA	0.587		NA											8	43					0	0	0	0
ZNF592	9640	broad.mit.edu	37	15	85328024	85328024	+	Silent	SNP	C	C	T			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr15:85328024C>T	uc002bld.2	+	4	2454	c.2118C>T	c.(2116-2118)CTC>CTT	p.L706L	ZNF592_uc010upb.1_RNA	NM_014630	NP_055445	Q92610	ZN592_HUMAN	zinc finger protein 592	706					cell death|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(4)|skin(2)	6			BRCA - Breast invasive adenocarcinoma(143;0.0587)			CTGTGAGGCTCATCCGGTACT	0.582		NA											7	70					0	0	0	0
C16orf91	283951	broad.mit.edu	37	16	1470388	1470388	+	Silent	SNP	G	G	A			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr16:1470388G>A	uc002clr.2	-	2	279	c.258C>T	c.(256-258)CTC>CTT	p.L86L	C16orf91_uc010uvd.1_Silent_p.L243L	NM_001010878	NP_001010878	Q4G0I0	CSMT1_HUMAN	hypothetical protein LOC283951	86	Helical; (Potential).					integral to membrane					0						TCAGCGCCACGAGGAAGCAGC	0.632		NA											15	74					0	0	0	0
COQ7	10229	broad.mit.edu	37	16	19085308	19085308	+	Silent	SNP	C	C	G			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr16:19085308C>G	uc002dfr.2	+	3	378	c.318C>G	c.(316-318)GTC>GTG	p.V106V	COQ7_uc002dfs.2_Silent_p.V92V	NM_016138	NP_057222	Q99807	COQ7_HUMAN	COQ7 protein	106	1.|2 X approximate tandem repeats.				ubiquinone biosynthetic process	mitochondrial inner membrane|nucleus	oxidoreductase activity|transition metal ion binding			skin(1)	1						CGTTCAGGGTCCGGCCAACAG	0.438		NA											5	23					0	0	0	0
TMC5	79838	broad.mit.edu	37	16	19505660	19505660	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr16:19505660C>T	uc002dgc.3	+	20	3652	c.2903C>T	c.(2902-2904)TCA>TTA	p.S968L	TMC5_uc010vaq.1_Missense_Mutation_p.S916L|TMC5_uc002dgb.3_Missense_Mutation_p.S910L|TMC5_uc010var.1_Missense_Mutation_p.S968L|TMC5_uc002dge.3_Missense_Mutation_p.S722L|TMC5_uc002dgf.3_Missense_Mutation_p.S651L|TMC5_uc002dgg.3_Missense_Mutation_p.S609L	NM_001105248	NP_001098718	Q6UXY8	TMC5_HUMAN	transmembrane channel-like 5 isoform a	968	Extracellular (Potential).					integral to membrane				skin(1)	1						AACCCCAGCTCACTTGTTCTG	0.488		NA											23	116					0	0	0	0
ATXN2L	11273	broad.mit.edu	37	16	28843600	28843600	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr16:28843600C>T	uc002drc.2	+	11	1564	c.1396C>T	c.(1396-1398)CCC>TCC	p.P466S	uc010vct.1_Intron|ATXN2L_uc010byl.1_Missense_Mutation_p.P466S|ATXN2L_uc002drb.2_Missense_Mutation_p.P466S|ATXN2L_uc002dqy.2_Missense_Mutation_p.P466S|ATXN2L_uc002dra.2_Missense_Mutation_p.P466S|ATXN2L_uc002dqz.2_Missense_Mutation_p.P466S|ATXN2L_uc010vdb.1_Missense_Mutation_p.P472S|ATXN2L_uc002dre.2_Missense_Mutation_p.P466S|ATXN2L_uc002drf.2_Intron|ATXN2L_uc002drg.2_5'Flank	NM_007245	NP_009176	Q8WWM7	ATX2L_HUMAN	ataxin 2 related protein isoform A	466						membrane				upper_aerodigestive_tract(1)|ovary(1)	2						TCCAGAGCCTCCCATCGGCTC	0.587		NA											10	53					0	0	0	0
SETD1A	9739	broad.mit.edu	37	16	30990939	30990939	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr16:30990939G>C	uc002ead.1	+	14	4518	c.3832G>C	c.(3832-3834)GAG>CAG	p.E1278Q		NM_014712	NP_055527	O15047	SET1A_HUMAN	SET domain containing 1A	1278					regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nuclear speck|Set1C/COMPASS complex	histone-lysine N-methyltransferase activity|nucleotide binding|protein binding|RNA binding			ovary(2)|skin(1)	3						TGAAGACTCAGAGGCCACAGA	0.701		NA											6	21					0	0	0	0
ZNF423	23090	broad.mit.edu	37	16	49672148	49672148	+	Silent	SNP	G	G	A			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr16:49672148G>A	uc002efs.2	-	5	1213	c.915C>T	c.(913-915)GTC>GTT	p.V305V	ZNF423_uc010vgn.1_Silent_p.V188V	NM_015069	NP_055884	Q2M1K9	ZN423_HUMAN	zinc finger protein 423	305	C2H2-type 7.				cell differentiation|negative regulation of transcription, DNA-dependent|nervous system development|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(1)|lung(1)|kidney(1)|pancreas(1)	4		all_cancers(37;0.0155)				TGTTCTCGTCGACGAAGACCT	0.607		NA											10	31					0	0	0	0
KIAA0182	23199	broad.mit.edu	37	16	85697133	85697133	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr16:85697133G>A	uc002fix.2	+	11	2631	c.2557G>A	c.(2557-2559)GAG>AAG	p.E853K	KIAA0182_uc002fiw.2_Missense_Mutation_p.E749K|KIAA0182_uc002fiy.2_Missense_Mutation_p.E780K|KIAA0182_uc002fiz.2_Missense_Mutation_p.E33K|KIAA0182_uc010cho.2_Missense_Mutation_p.E33K	NM_014615	NP_055430	Q14687	GSE1_HUMAN	genetic suppressor element 1 isoform 1	853							protein binding			large_intestine(3)|ovary(1)|skin(1)	5						CAGCCCTGATGAGATGAACAA	0.562		NA											21	55					0	0	0	0
PER1	5187	broad.mit.edu	37	17	8045157	8045157	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr17:8045157C>T	uc002gkd.2	-	22	3804	c.3566G>A	c.(3565-3567)CGG>CAG	p.R1189Q	PER1_uc010cns.2_Missense_Mutation_p.R63Q|PER1_uc010vuq.1_RNA	NM_002616	NP_002607	O15534	PER1_HUMAN	period 1	1189	CRY binding domain (By similarity).				circadian rhythm|entrainment of circadian clock|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	signal transducer activity			lung(2)|breast(2)|skin(2)|large_intestine(1)|ovary(1)|kidney(1)	9						TTGGCCCTTCCGGACCCAGGA	0.577		NA	T	ETV6	AML|CMML			Other_conserved_DNA_damage_response_genes					20	116					0	0	0	0
DNAH9	1770	broad.mit.edu	37	17	11520897	11520897	+	Silent	SNP	G	G	A			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr17:11520897G>A	uc002gne.2	+	5	1142	c.1074G>A	c.(1072-1074)CTG>CTA	p.L358L		NM_001372	NP_001363	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9 isoform 2	358	Stem (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			skin(10)|ovary(4)|breast(3)|central_nervous_system(2)|pancreas(1)	20		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		CGGGAAGGCTGACTGTGCTGC	0.612		NA											5	79					0	0	0	0
MYO15A	51168	broad.mit.edu	37	17	18025472	18025472	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr17:18025472C>T	uc010vxh.1	+	2	3696	c.3358C>T	c.(3358-3360)CGT>TGT	p.R1120C		NM_016239	NP_057323	Q9UKN7	MYO15_HUMAN	myosin XV	1120	Myosin head-like.				sensory perception of sound	cytoplasm|myosin complex|stereocilium	actin binding|ATP binding|calmodulin binding|motor activity			skin(4)|ovary(2)|pancreas(1)|breast(1)|central_nervous_system(1)	9	all_neural(463;0.228)					GGTCATGCCTCGTGTGCAGAA	0.652		NA											12	44					0	0	0	0
CCDC144NL	339184	broad.mit.edu	37	17	20799179	20799179	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr17:20799179C>G	uc002gyf.2	-	1	275	c.155G>C	c.(154-156)AGC>ACC	p.S52T	uc002gyg.1_Intron|uc002gyh.1_Intron	NM_001004306	NP_001004306	Q6NUI1	C144L_HUMAN	coiled-coil domain containing 144 family,	52											0						CTTCCACCAGCTGTAGGAGAA	0.622		NA											4	72					0	0	0	0
SEZ6	124925	broad.mit.edu	37	17	27286455	27286455	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr17:27286455C>T	uc002hdp.2	-	9	2001	c.1807G>A	c.(1807-1809)GTG>ATG	p.V603M	SEZ6_uc010crx.1_5'Flank|SEZ6_uc002hdm.2_RNA|SEZ6_uc010cry.1_Missense_Mutation_p.V603M|SEZ6_uc002hdq.1_Missense_Mutation_p.V478M	NM_178860	NP_849191	Q53EL9	SEZ6_HUMAN	seizure related 6 homolog isoform 1	603	Extracellular (Potential).|CUB 2.					integral to membrane|plasma membrane				large_intestine(1)|central_nervous_system(1)	2	Lung NSC(42;0.0137)		Epithelial(11;4.73e-06)|all cancers(11;2.91e-05)|BRCA - Breast invasive adenocarcinoma(11;8.06e-05)|OV - Ovarian serous cystadenocarcinoma(11;0.111)			GAGAGTACCACGCCAGCCGAG	0.587		NA											13	42					0	0	0	0
STAT5A	6776	broad.mit.edu	37	17	40458324	40458324	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr17:40458324G>A	uc002hzj.1	+	14	2181	c.1539G>A	c.(1537-1539)ATG>ATA	p.M513I	STAT5A_uc010cya.1_Missense_Mutation_p.M513I|STAT5A_uc010cyb.1_Missense_Mutation_p.M482I|STAT5A_uc010cyc.1_Missense_Mutation_p.M483I|STAT5A_uc010cyd.1_Missense_Mutation_p.M1I|STAT5A_uc010cye.1_Missense_Mutation_p.M1I	NM_003152	NP_003143	P42229	STA5A_HUMAN	signal transducer and activator of transcription	513					2-oxoglutarate metabolic process|allantoin metabolic process|citrate metabolic process|creatine metabolic process|creatinine metabolic process|fatty acid metabolic process|isoleucine metabolic process|oxaloacetate metabolic process|succinate metabolic process|taurine metabolic process|valine metabolic process	cytosol|nucleoplasm	calcium ion binding|DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			lung(1)	1		all_cancers(22;1.56e-06)|all_epithelial(22;3.17e-05)|Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.128)		CGCTCAACATGAAATTCAAGG	0.572		NA											12	65					0	0	0	0
BRCA1	672	broad.mit.edu	37	17	41243826	41243826	+	Missense_Mutation	SNP	G	G	A	rs80357143		TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr17:41243826G>A	uc002icq.2	-	10	3954	c.3722C>T	c.(3721-3723)TCT>TTT	p.S1241F	BRCA1_uc010whp.1_Intron|BRCA1_uc010whl.1_Intron|BRCA1_uc010whm.1_Intron|BRCA1_uc002icp.3_Missense_Mutation_p.S1170F|BRCA1_uc002icu.2_Intron|BRCA1_uc010cyx.2_Missense_Mutation_p.S1194F|BRCA1_uc002ict.2_Missense_Mutation_p.S1241F|BRCA1_uc010whn.1_Intron|BRCA1_uc010who.1_Intron|BRCA1_uc010whq.1_Intron|BRCA1_uc002idc.1_Intron|BRCA1_uc010whr.1_Intron|BRCA1_uc002idd.2_Missense_Mutation_p.S1241F|BRCA1_uc002ide.1_Missense_Mutation_p.S1072F|BRCA1_uc010cyy.1_Missense_Mutation_p.S1241F|BRCA1_uc010whs.1_Missense_Mutation_p.S1241F|BRCA1_uc010cyz.2_Missense_Mutation_p.S1194F|BRCA1_uc010cza.2_Missense_Mutation_p.S1215F|BRCA1_uc010wht.1_Missense_Mutation_p.S945F	NM_007294	NP_009225	P38398	BRCA1_HUMAN	breast cancer 1, early onset isoform 1	1241					androgen receptor signaling pathway|apoptosis|cellular response to indole-3-methanol|chromosome segregation|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|DNA damage response, signal transduction resulting in induction of apoptosis|double-strand break repair via homologous recombination|fatty acid biosynthetic process|G2/M transition DNA damage checkpoint|negative regulation of centriole replication|negative regulation of fatty acid biosynthetic process|negative regulation of histone H3-K9 methylation|negative regulation of transcription, DNA-dependent|positive regulation of cell cycle arrest|positive regulation of DNA repair|positive regulation of histone acetylation|positive regulation of histone H3-K4 methylation|positive regulation of histone H4-K20 methylation|positive regulation of protein ubiquitination|positive regulation of transcription from RNA polymerase II promoter|postreplication repair|protein autoubiquitination|protein K6-linked ubiquitination|regulation of cell motility|regulation of cell proliferation|regulation of transcription from RNA polymerase III promoter|response to estrogen stimulus|response to ionizing radiation|substrate adhesion-dependent cell spreading	BRCA1-A complex|BRCA1-BARD1 complex|gamma-tubulin ring complex|nucleoplasm|plasma membrane|ribonucleoprotein complex|ruffle	androgen receptor binding|identical protein binding|protein binding|RNA binding|transcription coactivator activity|transcription regulatory region DNA binding|tubulin binding|ubiquitin protein ligase binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(24)|breast(21)|lung(4)|central_nervous_system(1)|endometrium(1)|urinary_tract(1)	52		Breast(137;0.000717)		BRCA - Breast invasive adenocarcinoma(366;0.126)		ATGCCTAGTAGACTGAGAAGG	0.388		NA	D|Mis|N|F|S		ovarian	breast|ovarian		Homologous_recombination	Hereditary_Breast-Ovarian_Cancer_BRCA1_type	TCGA Ovarian(2;0.000030)			6	116					0	0	0	0
BRCA1	672	broad.mit.edu	37	17	41245102	41245102	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr17:41245102G>A	uc002icq.2	-	10	2678	c.2446C>T	c.(2446-2448)CAT>TAT	p.H816Y	BRCA1_uc010whp.1_Intron|BRCA1_uc010whl.1_Intron|BRCA1_uc010whm.1_Intron|BRCA1_uc002icp.3_Missense_Mutation_p.H745Y|BRCA1_uc002icu.2_Intron|BRCA1_uc010cyx.2_Missense_Mutation_p.H769Y|BRCA1_uc002ict.2_Missense_Mutation_p.H816Y|BRCA1_uc010whn.1_Intron|BRCA1_uc010who.1_Intron|BRCA1_uc010whq.1_Intron|BRCA1_uc002idc.1_Intron|BRCA1_uc010whr.1_Intron|BRCA1_uc002idd.2_Missense_Mutation_p.H816Y|BRCA1_uc002ide.1_Missense_Mutation_p.H647Y|BRCA1_uc010cyy.1_Missense_Mutation_p.H816Y|BRCA1_uc010whs.1_Missense_Mutation_p.H816Y|BRCA1_uc010cyz.2_Missense_Mutation_p.H769Y|BRCA1_uc010cza.2_Missense_Mutation_p.H790Y|BRCA1_uc010wht.1_Missense_Mutation_p.H520Y	NM_007294	NP_009225	P38398	BRCA1_HUMAN	breast cancer 1, early onset isoform 1	816					androgen receptor signaling pathway|apoptosis|cellular response to indole-3-methanol|chromosome segregation|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|DNA damage response, signal transduction resulting in induction of apoptosis|double-strand break repair via homologous recombination|fatty acid biosynthetic process|G2/M transition DNA damage checkpoint|negative regulation of centriole replication|negative regulation of fatty acid biosynthetic process|negative regulation of histone H3-K9 methylation|negative regulation of transcription, DNA-dependent|positive regulation of cell cycle arrest|positive regulation of DNA repair|positive regulation of histone acetylation|positive regulation of histone H3-K4 methylation|positive regulation of histone H4-K20 methylation|positive regulation of protein ubiquitination|positive regulation of transcription from RNA polymerase II promoter|postreplication repair|protein autoubiquitination|protein K6-linked ubiquitination|regulation of cell motility|regulation of cell proliferation|regulation of transcription from RNA polymerase III promoter|response to estrogen stimulus|response to ionizing radiation|substrate adhesion-dependent cell spreading	BRCA1-A complex|BRCA1-BARD1 complex|gamma-tubulin ring complex|nucleoplasm|plasma membrane|ribonucleoprotein complex|ruffle	androgen receptor binding|identical protein binding|protein binding|RNA binding|transcription coactivator activity|transcription regulatory region DNA binding|tubulin binding|ubiquitin protein ligase binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(24)|breast(21)|lung(4)|central_nervous_system(1)|endometrium(1)|urinary_tract(1)	52		Breast(137;0.000717)		BRCA - Breast invasive adenocarcinoma(366;0.126)		GAACAACCATGAATTAGTCCC	0.398		NA	D|Mis|N|F|S		ovarian	breast|ovarian		Homologous_recombination	Hereditary_Breast-Ovarian_Cancer_BRCA1_type	TCGA Ovarian(2;0.000030)			14	248					0	0	0	0
C17orf28	283987	broad.mit.edu	37	17	72955024	72955024	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr17:72955024C>A	uc002jmj.3	-	9	1280	c.1131G>T	c.(1129-1131)AAG>AAT	p.K377N	C17orf28_uc010wrs.1_Missense_Mutation_p.K176N|C17orf28_uc002jmk.2_Missense_Mutation_p.K376N	NM_030630	NP_085133	Q8IV36	CQ028_HUMAN	hypothetical protein LOC283987	377						integral to membrane|plasma membrane	protein binding				0	all_lung(278;0.151)|Lung NSC(278;0.185)					AGTCGCAGAGCTTCCAGAAGA	0.602		NA									OREG0024721	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	3	14					6.4e-05	7.15e-05	1	0
C17orf101	79701	broad.mit.edu	37	17	80363226	80363226	+	Silent	SNP	G	G	A			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr17:80363226G>A	uc002keu.1	-	6	620	c.519C>T	c.(517-519)TTC>TTT	p.F173F	C17orf101_uc002ket.1_Silent_p.F173F|C17orf101_uc010dip.1_RNA	NM_024648	NP_078924	Q6PK18	CQ101_HUMAN	hypothetical protein LOC79701 isoform 1	173	Lumenal (Potential).					integral to membrane	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			ovary(1)	1						CCTCCTCTGAGAAGATGTTCT	0.517		NA											12	31					0	0	0	0
KIAA0802	23255	broad.mit.edu	37	18	8784808	8784808	+	Silent	SNP	G	G	C			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr18:8784808G>C	uc002knr.2	+	6	1840	c.1698G>C	c.(1696-1698)GGG>GGC	p.G566G	KIAA0802_uc002knq.2_Silent_p.G566G|KIAA0802_uc010dkw.1_Silent_p.G404G	NM_015210	NP_056025	Q9Y4B5	CC165_HUMAN	hypothetical protein LOC23255	917											0						CCCCCATCGGGAACCTGGGGA	0.632		NA											11	58					0	0	0	0
CCDC11	220136	broad.mit.edu	37	18	47765019	47765019	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr18:47765019C>T	uc002lee.2	-	7	1361	c.1270G>A	c.(1270-1272)GAA>AAA	p.E424K		NM_145020	NP_659457	Q96M91	CCD11_HUMAN	coiled-coil domain containing 11	424	Potential.									ovary(1)|pancreas(1)|skin(1)	3				STAD - Stomach adenocarcinoma(97;2.66e-05)|Colorectal(21;7.57e-05)|Lung(128;0.00932)|READ - Rectum adenocarcinoma(32;0.164)		TTAAGACTTTCATTTATGTGT	0.313		NA											9	33					0	0	0	0
MIER2	54531	broad.mit.edu	37	19	327204	327204	+	Nonsense_Mutation	SNP	G	G	T			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr19:327204G>T	uc002lok.1	-	5	431	c.422C>A	c.(421-423)TCA>TAA	p.S141*		NM_017550	NP_060020	Q8N344	MIER2_HUMAN	mesoderm induction early response 1, family	141					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding				0		all_cancers(10;1.05e-30)|all_epithelial(18;3.04e-19)|Acute lymphoblastic leukemia(61;4.36e-14)|all_hematologic(61;4.84e-09)|Lung NSC(49;2.49e-05)|all_lung(49;4.36e-05)|Breast(49;0.000304)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GTCAGCAGATGATTGCGTCTC	0.468		NA											12	216					3.07e-06	3.47e-06	1	0
MPND	84954	broad.mit.edu	37	19	4359198	4359198	+	Silent	SNP	C	C	T	rs141733787	by1000genomes	TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr19:4359198C>T	uc002mae.2	+	11	1342	c.1275C>T	c.(1273-1275)CTC>CTT	p.L425L	MPND_uc010dtx.2_RNA|MPND_uc002mag.2_Silent_p.L405L|MPND_uc002maf.2_Silent_p.L455L|MPND_uc002mah.2_Silent_p.L313L|MPND_uc002mai.2_Silent_p.L314L	NM_032868	NP_116257	Q8N594	MPND_HUMAN	MPN domain containing isoform 1	425							peptidase activity			breast(1)	1				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0149)|STAD - Stomach adenocarcinoma(1328;0.18)		CCCCTGACCTCGTGAGGCTCC	0.622		NA											10	55					0	0	0	0
ZNF98	148198	broad.mit.edu	37	19	22575483	22575483	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr19:22575483T>C	uc002nqt.2	-	4	676	c.554A>G	c.(553-555)AAA>AGA	p.K185R		NM_001098626	NP_001092096	A6NK75	ZNF98_HUMAN	zinc finger protein 98	185	C2H2-type 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|skin(1)	2		all_cancers(12;0.0536)|all_lung(12;0.00187)|Lung NSC(12;0.0019)|all_epithelial(12;0.00542)|Hepatocellular(1079;0.244)				TTCACATTCTTTACACTTGAA	0.303		NA											2	8					0	0	0	0
PVRL2	5819	broad.mit.edu	37	19	45375325	45375325	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr19:45375325G>A	uc002ozw.1	+	3	1084	c.694G>A	c.(694-696)GAT>AAT	p.D232N	PVRL2_uc002ozv.2_Missense_Mutation_p.D232N	NM_001042724	NP_001036189	Q92692	PVRL2_HUMAN	poliovirus receptor related 2 isoform delta	232	Ig-like C2-type 1.|Extracellular (Potential).				adherens junction organization|adhesion to symbiont|cell junction assembly|homophilic cell adhesion|positive regulation of immunoglobulin mediated immune response|positive regulation of mast cell activation|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target|susceptibility to natural killer cell mediated cytotoxicity|susceptibility to T cell mediated cytotoxicity|viral envelope fusion with host membrane|virion attachment, binding of host cell surface coreceptor	cell surface|integral to membrane|zonula adherens	cell adhesion molecule binding|coreceptor activity|protein homodimerization activity				0	Lung NSC(12;0.00195)|all_lung(12;0.00522)	Ovarian(192;0.0728)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.0143)		GGGCCGAGCAGATGGTGTCAC	0.597		NA											5	63					0	0	0	0
PVRL2	5819	broad.mit.edu	37	19	45375367	45375367	+	Missense_Mutation	SNP	G	G	A	rs138153191		TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr19:45375367G>A	uc002ozw.1	+	3	1126	c.736G>A	c.(736-738)GAG>AAG	p.E246K	PVRL2_uc002ozv.2_Missense_Mutation_p.E246K	NM_001042724	NP_001036189	Q92692	PVRL2_HUMAN	poliovirus receptor related 2 isoform delta	246	Ig-like C2-type 1.|Extracellular (Potential).				adherens junction organization|adhesion to symbiont|cell junction assembly|homophilic cell adhesion|positive regulation of immunoglobulin mediated immune response|positive regulation of mast cell activation|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target|susceptibility to natural killer cell mediated cytotoxicity|susceptibility to T cell mediated cytotoxicity|viral envelope fusion with host membrane|virion attachment, binding of host cell surface coreceptor	cell surface|integral to membrane|zonula adherens	cell adhesion molecule binding|coreceptor activity|protein homodimerization activity				0	Lung NSC(12;0.00195)|all_lung(12;0.00522)	Ovarian(192;0.0728)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.0143)		TGAGAGCTTCGAGGAACCAGC	0.592		NA											5	73					0	0	0	0
NLRP12	91662	broad.mit.edu	37	19	54313983	54313983	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr19:54313983C>A	uc002qch.3	-	3	1150	c.930G>T	c.(928-930)TGG>TGT	p.W310C	NLRP12_uc010eqw.2_5'Flank|NLRP12_uc002qci.3_Missense_Mutation_p.W310C|NLRP12_uc002qcj.3_Missense_Mutation_p.W310C|NLRP12_uc002qck.3_RNA|NLRP12_uc010eqx.2_Missense_Mutation_p.W310C	NM_144687	NP_653288	P59046	NAL12_HUMAN	NLR family, pyrin domain containing 12 isoform	310	NACHT.				negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of interleukin-1 secretion|negative regulation of interleukin-6 biosynthetic process|negative regulation of protein autophosphorylation|negative regulation of Toll signaling pathway|positive regulation of inflammatory response|positive regulation of interleukin-1 beta secretion|regulation of interleukin-18 biosynthetic process|release of cytoplasmic sequestered NF-kappaB	cytoplasm	ATP binding|caspase activator activity|protein binding			ovary(4)|upper_aerodigestive_tract(2)|lung(1)	7	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.026)		AGCAGAGGCACCAGGGTCCCT	0.572		NA											6	57					3.6e-05	4.04e-05	1	0
PEG3	5178	broad.mit.edu	37	19	57335885	57335885	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr19:57335885G>C	uc002qnu.2	-	1	490	c.139C>G	c.(139-141)CAG>GAG	p.Q47E	ZIM2_uc010ygq.1_Intron|ZIM2_uc010ygr.1_Intron|ZIM2_uc002qnr.2_Intron|ZIM2_uc002qnq.2_Intron|ZIM2_uc010etp.2_Intron|ZIM2_uc010ygs.1_Intron|PEG3_uc002qnt.2_Missense_Mutation_p.Q47E|PEG3_uc002qnv.2_Missense_Mutation_p.Q47E|PEG3_uc002qnw.2_Intron|PEG3_uc002qnx.2_Intron|PEG3_uc010etr.2_Missense_Mutation_p.Q47E	NM_001146186	NP_001139658	Q9GZU2	PEG3_HUMAN	paternally expressed 3 isoform 1	47	SCAN box.				apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)		CGAAACCTCTGATGAAAAAAC	0.502		NA											14	51					0	0	0	0
ZNF547	284306	broad.mit.edu	37	19	57889020	57889020	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr19:57889020C>G	uc002qol.2	+	4	869	c.676C>G	c.(676-678)CAC>GAC	p.H226D	ZNF547_uc002qpm.3_Missense_Mutation_p.H152D|ZNF547_uc010ygx.1_Missense_Mutation_p.H226D	NM_173631	NP_775902	Q8IVP9	ZN547_HUMAN	zinc finger protein 547	226	C2H2-type 4.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|central_nervous_system(1)	2		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0694)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		TTGTAAGTCTCACCTTGTTCG	0.433		NA											5	84					0	0	0	0
KIDINS220	57498	broad.mit.edu	37	2	8934023	8934023	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr2:8934023T>C	uc002qzc.2	-	12	1375	c.1193A>G	c.(1192-1194)TAT>TGT	p.Y398C	KIDINS220_uc010yiv.1_Missense_Mutation_p.Y164C|KIDINS220_uc002qzd.2_Missense_Mutation_p.Y356C|KIDINS220_uc010yiw.1_Missense_Mutation_p.Y399C	NM_020738	NP_065789	Q9ULH0	KDIS_HUMAN	kinase D-interacting substrate of 220 kDa	398	Cytoplasmic (Potential).				activation of MAPKK activity|nerve growth factor receptor signaling pathway	cytosol|integral to membrane				ovary(3)|central_nervous_system(1)	4	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)					GTTGGGCCTATAAAGTAATCG	0.403		NA											15	46					0	0	0	0
SLC8A1	6546	broad.mit.edu	37	2	40655980	40655980	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr2:40655980C>G	uc002rrx.2	-	1	1465	c.1441G>C	c.(1441-1443)GAT>CAT	p.D481H	SLC8A1_uc002rry.2_Missense_Mutation_p.D481H|SLC8A1_uc002rrz.2_Missense_Mutation_p.D481H|SLC8A1_uc002rsa.2_Missense_Mutation_p.D481H|SLC8A1_uc002rsd.3_Missense_Mutation_p.D481H|SLC8A1_uc002rsb.1_Missense_Mutation_p.D481H|SLC8A1_uc010fan.1_Missense_Mutation_p.D481H|SLC8A1_uc002rsc.1_Missense_Mutation_p.D481H	NM_021097	NP_066920	P32418	NAC1_HUMAN	solute carrier family 8 (sodium/calcium	481	Calx-beta 1.|Cytoplasmic (Potential).				cell communication|muscle contraction|platelet activation	integral to plasma membrane	calcium:sodium antiporter activity|calmodulin binding|heat shock protein binding			ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	4					Alpha-Linolenic Acid(DB00132)|Icosapent(DB00159)	ATATCATCATCTATGATACCC	0.418		NA											4	59					0	0	0	0
BCL11A	53335	broad.mit.edu	37	2	60688312	60688312	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr2:60688312C>T	uc002sae.1	-	4	1963	c.1735G>A	c.(1735-1737)GAG>AAG	p.E579K	BCL11A_uc002sab.2_Missense_Mutation_p.E579K|BCL11A_uc002sac.2_Intron|BCL11A_uc010ypi.1_Missense_Mutation_p.E248K|BCL11A_uc010ypj.1_Missense_Mutation_p.E545K|BCL11A_uc002sad.1_Missense_Mutation_p.E427K|BCL11A_uc002saf.1_Missense_Mutation_p.E545K	NM_022893	NP_075044	Q9H165	BC11A_HUMAN	B-cell CLL/lymphoma 11A isoform 1	579					negative regulation of axon extension|negative regulation of collateral sprouting|negative regulation of dendrite development|positive regulation of collateral sprouting|positive regulation of neuron projection development|positive regulation of transcription from RNA polymerase II promoter|protein sumoylation|regulation of dendrite development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|cytoplasm|nucleus|nucleus	nucleic acid binding|protein heterodimerization activity|protein homodimerization activity|zinc ion binding			central_nervous_system(6)|breast(3)|ovary(2)|skin(2)	13			LUSC - Lung squamous cell carcinoma(5;9.29e-08)|Lung(5;1.34e-06)|Epithelial(17;0.0562)|all cancers(80;0.199)			CTGTGGCCCTCGGCCTCGGCC	0.667		NA	T	IGH@	B-CLL								6	24					0	0	0	0
REG3G	130120	broad.mit.edu	37	2	79255340	79255340	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr2:79255340C>G	uc002snw.2	+	6	551	c.466C>G	c.(466-468)CTG>GTG	p.L156V	REG3G_uc002snx.2_Missense_Mutation_p.L156V|REG3G_uc010ffu.2_Missense_Mutation_p.L110V	NM_198448	NP_940850	Q6UW15	REG3G_HUMAN	regenerating islet-derived 3 gamma precursor	156	C-type lectin.				acute-phase response	extracellular region	sugar binding				0						CCTAGGATTTCTGAAGTGGAA	0.483		NA											12	54					0	0	0	0
REG1A	5967	broad.mit.edu	37	2	79349207	79349207	+	Missense_Mutation	SNP	A	A	T			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr2:79349207A>T	uc002snz.2	+	4	380	c.277A>T	c.(277-279)ACT>TCT	p.T93S	REG1A_uc010ffx.1_3'UTR|REG1A_uc010ysd.1_Missense_Mutation_p.T93S	NM_002909	NP_002900	P05451	REG1A_HUMAN	regenerating islet-derived 1 alpha precursor	93	C-type lectin.				positive regulation of cell proliferation	extracellular region	growth factor activity|sugar binding				0						GGAGAGTGGCACTGATGACTT	0.507		NA											17	59					0	0	0	0
IMMT	10989	broad.mit.edu	37	2	86398430	86398430	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr2:86398430C>T	uc002sqz.3	-	5	848	c.460G>A	c.(460-462)GAT>AAT	p.D154N	IMMT_uc002sqy.3_5'UTR|IMMT_uc002srb.3_Missense_Mutation_p.D143N|IMMT_uc002sra.3_Missense_Mutation_p.D154N|IMMT_uc010ytd.1_Missense_Mutation_p.D142N|IMMT_uc010yte.1_Intron|IMMT_uc002src.1_5'UTR|IMMT_uc002srd.2_Missense_Mutation_p.D154N|IMMT_uc002sre.3_Missense_Mutation_p.D143N|IMMT_uc010ytf.1_Intron|IMMT_uc010fgs.1_Missense_Mutation_p.D151N	NM_006839	NP_006830	Q16891	IMMT_HUMAN	inner membrane protein, mitochondrial isoform 1	154	Mitochondrial intermembrane (Potential).			D -> E (in Ref. 4; BAG35183).		integral to mitochondrial inner membrane	protein binding			skin(1)	1						GACAGGGTATCACCTGCTGCA	0.438		NA											3	10					0	0	0	0
LIPT1	51601	broad.mit.edu	37	2	99779504	99779504	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr2:99779504T>C	uc002szm.3	+	4	1424	c.1084T>C	c.(1084-1086)TGG>CGG	p.W362R	MRPL30_uc002szl.1_Intron|LIPT1_uc002szn.3_Missense_Mutation_p.W362R|LIPT1_uc002szo.3_Missense_Mutation_p.W362R|LIPT1_uc002szp.3_Missense_Mutation_p.W362R|LIPT1_uc002szq.3_Missense_Mutation_p.W362R|MRPL30_uc002szr.2_Intron	NM_145198	NP_660199	Q9Y234	LIPT_HUMAN	lipoyltransferase 1 precursor	362					lipid metabolic process|protein lipoylation	mitochondrion	acyltransferase activity				0					Lipoic Acid(DB00166)	AAACAGTAAATGGAATATTCT	0.303		NA											8	66					0	0	0	0
MARCO	8685	broad.mit.edu	37	2	119750046	119750046	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr2:119750046G>A	uc002tln.1	+	15	1378	c.1246G>A	c.(1246-1248)GAA>AAA	p.E416K	MARCO_uc010yyf.1_Missense_Mutation_p.E338K	NM_006770	NP_006761	Q9UEW3	MARCO_HUMAN	macrophage receptor with collagenous structure	416	Collagen-like.|Extracellular (Potential).				cell surface receptor linked signaling pathway|innate immune response	collagen|integral to plasma membrane	pattern recognition receptor activity|scavenger receptor activity			ovary(3)|skin(2)|central_nervous_system(1)	6						AGAAAAAGGTGAAAGAGGTAA	0.433		NA											4	38					0	0	0	0
NEB	4703	broad.mit.edu	37	2	152521102	152521102	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr2:152521102C>T	uc010fnx.2	-	44	5555	c.5364G>A	c.(5362-5364)TGG>TGA	p.W1788*		NM_004543	NP_004534	P20929	NEBU_HUMAN	nebulin isoform 3	1788	Nebulin 46.				muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			ovary(8)|large_intestine(5)|breast(3)|central_nervous_system(2)|skin(1)|pancreas(1)	20				BRCA - Breast invasive adenocarcinoma(221;0.219)		TTTCCTCTTCCCAGCCAGCTT	0.418		NA											5	14					0	0	0	0
SLC4A10	57282	broad.mit.edu	37	2	162735688	162735688	+	Silent	SNP	G	G	A			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr2:162735688G>A	uc002ubx.3	+	9	1180	c.996G>A	c.(994-996)TCG>TCA	p.S332S	SLC4A10_uc010fpa.1_Silent_p.S344S|SLC4A10_uc010zcr.1_RNA|SLC4A10_uc002uby.3_Silent_p.S302S|SLC4A10_uc010zcs.1_Silent_p.S313S	NM_022058	NP_071341	Q6U841	S4A10_HUMAN	solute carrier family 4, sodium bicarbonate	332	Cytoplasmic (Potential).				bicarbonate transport|chloride transport|sodium ion transport	integral to membrane|plasma membrane	inorganic anion exchanger activity|symporter activity			ovary(2)|lung(2)|pancreas(1)	5						CTGAAGCATCGAACATCTTAG	0.418		NA											9	51					0	0	0	0
XIRP2	129446	broad.mit.edu	37	2	168106863	168106863	+	Silent	SNP	G	G	C			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr2:168106863G>C	uc002udx.2	+	8	8979	c.8961G>C	c.(8959-8961)CTG>CTC	p.L2987L	XIRP2_uc010fpn.2_Intron|XIRP2_uc010fpo.2_Intron|XIRP2_uc010fpp.2_Intron|XIRP2_uc002udy.2_Silent_p.L2812L|XIRP2_uc010fpq.2_Silent_p.L2765L|XIRP2_uc010fpr.2_Intron|XIRP2_uc010fps.1_Silent_p.L333L	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	2812					actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14						CAGGATGGCTGATAAGTGAAG	0.343		NA											22	96					0	0	0	0
PDK1	5163	broad.mit.edu	37	2	173429352	173429352	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr2:173429352C>G	uc002uhr.2	+	4	632	c.532C>G	c.(532-534)CAG>GAG	p.Q178E	PDK1_uc010zdz.1_Missense_Mutation_p.Q23E|PDK1_uc010zea.1_RNA|PDK1_uc002uhq.1_Missense_Mutation_p.Q198E|PDK1_uc002uhs.2_Missense_Mutation_p.Q178E|PDK1_uc010zeb.1_Missense_Mutation_p.Q198E	NM_002610	NP_002601	Q15118	PDK1_HUMAN	pyruvate dehydrogenase kinase 1 precursor	178	Histidine kinase.				glucose metabolic process|peptidyl-histidine phosphorylation|pyruvate metabolic process|regulation of acetyl-CoA biosynthetic process from pyruvate|small GTPase mediated signal transduction	mitochondrial matrix	ATP binding|pyruvate dehydrogenase (acetyl-transferring) kinase activity|two-component sensor activity			lung(3)|central_nervous_system(1)	4			OV - Ovarian serous cystadenocarcinoma(117;0.12)			CCAGAATGTTCAGTACTTTTT	0.433		NA							Autosomal_Dominant_Polycystic_Kidney_Disease				6	65					0	0	0	0
TTN	7273	broad.mit.edu	37	2	179411092	179411092	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr2:179411092G>C	uc010zfg.1	-	291	87486	c.87262C>G	c.(87262-87264)CTA>GTA	p.L29088V	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.L22783V|TTN_uc010zfi.1_Missense_Mutation_p.L22716V|TTN_uc010zfj.1_Missense_Mutation_p.L22591V	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	30015							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CAGAGATCTAGCTCCTTGTCT	0.438		NA											14	74					0	0	0	0
TTN	7273	broad.mit.edu	37	2	179411461	179411461	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr2:179411461G>C	uc010zfg.1	-	290	87214	c.86990C>G	c.(86989-86991)TCT>TGT	p.S28997C	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.S22692C|TTN_uc010zfi.1_Missense_Mutation_p.S22625C|TTN_uc010zfj.1_Missense_Mutation_p.S22500C	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	29924							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GAAATTGTCAGATACAATGGT	0.483		NA											15	43					0	0	0	0
TTN	7273	broad.mit.edu	37	2	179585815	179585815	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr2:179585815C>T	uc010zfg.1	-	76	19423	c.19199G>A	c.(19198-19200)CGA>CAA	p.R6400Q	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.R3061Q	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	7327							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GCTGTCATTTCGGAACCATGA	0.393		NA											15	73					0	0	0	0
SPHKAP	80309	broad.mit.edu	37	2	228882641	228882641	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr2:228882641G>A	uc002vpq.2	-	7	2976	c.2929C>T	c.(2929-2931)CGA>TGA	p.R977*	SPHKAP_uc002vpp.2_Nonsense_Mutation_p.R977*|SPHKAP_uc010zlx.1_Nonsense_Mutation_p.R977*	NM_001142644	NP_001136116	Q2M3C7	SPKAP_HUMAN	sphingosine kinase type 1-interacting protein	977						cytoplasm	protein binding			skin(5)|ovary(4)|lung(1)	10		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;8.17e-11)|all cancers(144;7.92e-08)|Lung(261;0.0168)|LUSC - Lung squamous cell carcinoma(224;0.0232)		TTCAAGGATCGGCAGGGTACG	0.532		NA											22	56					0	0	0	0
CSNK2A1	1457	broad.mit.edu	37	20	468206	468206	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr20:468206G>A	uc002wdw.1	-	12	1231	c.838C>T	c.(838-840)CGA>TGA	p.R280*	CSNK2A1_uc002wdx.1_Nonsense_Mutation_p.R280*|CSNK2A1_uc002wdy.1_Nonsense_Mutation_p.R144*	NM_177559	NP_808227	P68400	CSK21_HUMAN	casein kinase II alpha 1 subunit isoform a	280	Protein kinase.				axon guidance|Wnt receptor signaling pathway	cytosol|NuRD complex|plasma membrane|Sin3 complex	ATP binding|protein N-terminus binding|protein serine/threonine kinase activity			ovary(1)	1		Breast(17;0.231)	OV - Ovarian serous cystadenocarcinoma(29;0.0969)			CGTTCCCATCGCTTTCGAGAG	0.507		NA											5	61					0	0	0	0
SLC4A11	83959	broad.mit.edu	37	20	3209061	3209061	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr20:3209061G>A	uc002wig.2	-	18	2498	c.2450C>T	c.(2449-2451)CCG>CTG	p.P817L	SLC4A11_uc010zqe.1_Missense_Mutation_p.P844L|SLC4A11_uc002wih.2_RNA|SLC4A11_uc010zqf.1_Missense_Mutation_p.P801L	NM_032034	NP_114423	Q8NBS3	S4A11_HUMAN	solute carrier family 4 member 11	817	Membrane (bicarbonate transporter).				cellular cation homeostasis|fluid transport|phosphoenolpyruvate-dependent sugar phosphotransferase system	basolateral plasma membrane|integral to membrane	bicarbonate transmembrane transporter activity|borate transmembrane transporter activity|hydrogen ion channel activity|inorganic anion exchanger activity|sodium channel activity|sugar:hydrogen symporter activity			ovary(1)	1						GTAGTGTGTCGGGGGGTACGC	0.672		NA											16	97					0	0	0	0
C20orf132	140699	broad.mit.edu	37	20	35783534	35783534	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr20:35783534C>G	uc010zvu.1	-	11	1127	c.1036G>C	c.(1036-1038)GAG>CAG	p.E346Q	C20orf132_uc002xgk.2_Intron|C20orf132_uc002xgm.2_Missense_Mutation_p.E346Q|C20orf132_uc002xgn.2_Intron	NM_152503	NP_689716	Q9H579	CT132_HUMAN	hypothetical protein LOC140699 isoform 1	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment											0		Myeloproliferative disorder(115;0.00878)				CGTTCCCGCTCATGGTCTTTG	0.498		NA											26	97					0	0	0	0
PTPRT	11122	broad.mit.edu	37	20	41100954	41100954	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr20:41100954C>T	uc002xkg.2	-	8	1586	c.1402G>A	c.(1402-1404)GAG>AAG	p.E468K	PTPRT_uc010ggj.2_Missense_Mutation_p.E468K	NM_007050	NP_008981	O14522	PTPRT_HUMAN	protein tyrosine phosphatase, receptor type, T	468	Extracellular (Potential).|Fibronectin type-III 2.				homophilic cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	cell surface|integral to membrane|plasma membrane	alpha-catenin binding|beta-catenin binding|cadherin binding|delta-catenin binding|gamma-catenin binding|protein tyrosine phosphatase activity|receptor activity			skin(8)|ovary(7)|lung(5)	20		Myeloproliferative disorder(115;0.00452)|Lung NSC(126;0.0573)|all_lung(126;0.0783)				ATTCGGCCCTCGGGGTTAGAC	0.592		NA											20	60					0	0	0	0
ELMO2	63916	broad.mit.edu	37	20	45000318	45000318	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr20:45000318C>G	uc002xrt.1	-	18	1803	c.1593G>C	c.(1591-1593)GAG>GAC	p.E531D	ELMO2_uc010zxq.1_Missense_Mutation_p.E263D|ELMO2_uc002xrs.1_Missense_Mutation_p.E278D|ELMO2_uc002xru.1_Missense_Mutation_p.E531D|ELMO2_uc010zxr.1_Missense_Mutation_p.E543D|ELMO2_uc010zxs.1_Missense_Mutation_p.E348D|ELMO2_uc002xrv.1_Missense_Mutation_p.E250D	NM_133171	NP_573403	Q96JJ3	ELMO2_HUMAN	engulfment and cell motility 2	531					apoptosis|cell chemotaxis|phagocytosis	cytoskeleton|cytosol|membrane	lyase activity|receptor tyrosine kinase binding|SH3 domain binding			ovary(1)	1		Myeloproliferative disorder(115;0.0122)				GCTGGATCTTCTCCCTCAGCT	0.617		NA											8	37					0	0	0	0
PREX1	57580	broad.mit.edu	37	20	47274751	47274751	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr20:47274751C>T	uc002xtw.1	-	17	1920	c.1897G>A	c.(1897-1899)GAG>AAG	p.E633K	PREX1_uc002xtv.1_5'Flank	NM_020820	NP_065871	Q8TCU6	PREX1_HUMAN	phosphatidylinositol-3,4,	633	PDZ.				actin filament polymerization|apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|neutrophil activation|small GTPase mediated signal transduction|superoxide metabolic process	cytosol|plasma membrane	enzyme binding|phospholipid binding|Rho GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			lung(3)|ovary(2)|pancreas(1)	6			BRCA - Breast invasive adenocarcinoma(12;0.0135)|Colorectal(8;0.198)			CCATAGTCCTCCTCCTGGGGC	0.672		NA									OREG0026010	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	14	206					0	0	0	0
MYT1	4661	broad.mit.edu	37	20	62839693	62839693	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr20:62839693G>C	uc002yii.2	+	7	1508	c.1144G>C	c.(1144-1146)GAG>CAG	p.E382Q	MYT1_uc002yih.2_Intron|MYT1_uc002yij.2_Missense_Mutation_p.E14Q	NM_004535	NP_004526	Q01538	MYT1_HUMAN	myelin transcription factor 1	382					cell differentiation|nervous system development	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2	all_cancers(38;1.82e-11)|all_epithelial(29;3.3e-13)|Lung NSC(23;5.21e-10)|all_lung(23;1.92e-09)					GGGCCTCCTGGAGCAGGCCAT	0.647		NA											11	50					0	0	0	0
PKNOX1	5316	broad.mit.edu	37	21	44450050	44450050	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr21:44450050C>T	uc002zcq.1	+	11	1338	c.1150C>T	c.(1150-1152)CAG>TAG	p.Q384*	PKNOX1_uc011aex.1_Nonsense_Mutation_p.Q267*	NM_004571	NP_004562	P55347	PKNX1_HUMAN	PBX/knotted 1 homeobox 1	384							sequence-specific DNA binding			large_intestine(2)	2						GGACAGCCTTCAGTCTCTGTC	0.567		NA											18	87					0	0	0	0
MN1	4330	broad.mit.edu	37	22	28193511	28193511	+	Silent	SNP	C	C	T			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr22:28193511C>T	uc003adj.2	-	1	3976	c.3021G>A	c.(3019-3021)TCG>TCA	p.S1007S		NM_002430	NP_002421	Q10571	MN1_HUMAN	meningioma  1	1007							binding			central_nervous_system(3)|lung(3)|large_intestine(1)|breast(1)|skin(1)|ovary(1)	10						CCCAGGATGGCGACGTGAGCG	0.697		NA	T	ETV6	AML|meningioma								15	58					0	0	0	0
ARL8B	55207	broad.mit.edu	37	3	5215724	5215724	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr3:5215724G>C	uc003bqg.2	+	5	616	c.395G>C	c.(394-396)AGA>ACA	p.R132T	ARL8B_uc011asx.1_Missense_Mutation_p.R123T|ARL8B_uc011asy.1_Intron	NM_018184	NP_060654	Q9NVJ2	ARL8B_HUMAN	ADP-ribosylation factor-like 10C	132	GTP.				cell cycle|cell division|chromosome segregation|small GTPase mediated signal transduction	late endosome membrane|lysosomal membrane|midbody|spindle midzone	alpha-tubulin binding|beta-tubulin binding|GDP binding|GTP binding|GTPase activity				0				OV - Ovarian serous cystadenocarcinoma(96;0.0717)|Epithelial(13;0.0777)		GGAAACAAGAGAGATCTTCCT	0.313		NA											17	177					0	0	0	0
NR1D2	9975	broad.mit.edu	37	3	24018766	24018766	+	Silent	SNP	C	C	T	rs138945807	byFrequency	TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr3:24018766C>T	uc003ccs.2	+	8	1915	c.1596C>T	c.(1594-1596)CTC>CTT	p.L532L	NR1D2_uc010hfd.2_RNA|NR1D2_uc011awk.1_Silent_p.L457L	NM_005126	NP_005117	Q14995	NR1D2_HUMAN	nuclear receptor subfamily 1, group D, member 2	532					regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	sequence-specific DNA binding|steroid hormone receptor activity|zinc ion binding			urinary_tract(1)|kidney(1)|skin(1)	3						AGGAAACTCTCATTCGTGCAC	0.368		NA											5	32					0	0	0	0
UQCRC1	7384	broad.mit.edu	37	3	48641703	48641703	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr3:48641703G>C	uc003cub.1	-	5	634	c.589C>G	c.(589-591)CTA>GTA	p.L197V	UQCRC1_uc003cua.1_Missense_Mutation_p.L82V|UQCRC1_uc003cuc.1_Missense_Mutation_p.L197V|UQCRC1_uc003cud.1_Missense_Mutation_p.L197V	NM_003365	NP_003356	P31930	QCR1_HUMAN	ubiquinol-cytochrome c reductase core protein I	197					aerobic respiration|proteolysis		metalloendopeptidase activity|ubiquinol-cytochrome-c reductase activity|zinc ion binding				0				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00551)|Kidney(197;0.00621)	Atovaquone(DB01117)	GCCTGGGCTAGAGGTGTGCCC	0.572		NA											5	93					0	0	0	0
QTRTD1	79691	broad.mit.edu	37	3	113798870	113798870	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr3:113798870C>A	uc003eay.2	+	8	1094	c.864C>A	c.(862-864)TTC>TTA	p.F288L	QTRTD1_uc003eaz.2_Missense_Mutation_p.F300L|QTRTD1_uc011biq.1_Missense_Mutation_p.F165L|QTRTD1_uc011bir.1_Missense_Mutation_p.F182L	NM_024638	NP_078914	Q9H974	QTRD1_HUMAN	queuine tRNA-ribosyltransferase domain	288					queuosine biosynthetic process	mitochondrion	metal ion binding|queuine tRNA-ribosyltransferase activity			central_nervous_system(1)|skin(1)	2						CCCTGACTTTCAGTTTTGATT	0.413		NA											32	194					6.71e-13	7.69e-13	1	0
NEK11	79858	broad.mit.edu	37	3	131068603	131068603	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr3:131068603C>T	uc003eny.2	+	18	2247	c.1921C>T	c.(1921-1923)CTC>TTC	p.L641F	uc003eoc.1_Intron|NEK11_uc003eoa.2_3'UTR|NEK11_uc003enz.2_Missense_Mutation_p.L459F|NEK11_uc010htn.2_RNA|NEK11_uc011blk.1_Missense_Mutation_p.L457F|NEK11_uc011bll.1_Missense_Mutation_p.L536F	NM_024800	NP_079076	Q8NG66	NEK11_HUMAN	NIMA-related kinase 11 isoform 1	641					cell cycle|intra-S DNA damage checkpoint|intracellular protein kinase cascade	nucleolus	ATP binding|identical protein binding|metal ion binding|protein serine/threonine kinase activity			large_intestine(4)|stomach(1)|central_nervous_system(1)	6						AGAACCTACTCTCCAGAACCA	0.403		NA											5	78					0	0	0	0
ZBTB38	253461	broad.mit.edu	37	3	141163374	141163374	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr3:141163374C>T	uc003etw.2	+	8	3126	c.2144C>T	c.(2143-2145)TCG>TTG	p.S715L	ZBTB38_uc010hun.2_Missense_Mutation_p.S712L|ZBTB38_uc010huo.2_Missense_Mutation_p.S715L|ZBTB38_uc003ety.2_Missense_Mutation_p.S715L|ZBTB38_uc010hup.2_Missense_Mutation_p.S716L	NM_001080412	NP_001073881	Q8NAP3	ZBT38_HUMAN	zinc finger and BTB domain containing 38	715					positive regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(3)	3						TCTGCACCCTCGGTCATTGTA	0.522		NA											19	128					0	0	0	0
SI	6476	broad.mit.edu	37	3	164754187	164754187	+	Silent	SNP	T	T	C			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr3:164754187T>C	uc003fei.2	-	22	2567	c.2505A>G	c.(2503-2505)GGA>GGG	p.G835G		NM_001041	NP_001032	P14410	SUIS_HUMAN	sucrase-isomaltase	835	Lumenal.|Isomaltase.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			ovary(7)|upper_aerodigestive_tract(4)|skin(2)|pancreas(1)	14		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	CTTTAGTTTCTCCATCATCCC	0.343		NA								HNSCC(35;0.089)			4	74					0	0	0	0
PLD1	5337	broad.mit.edu	37	3	171404477	171404477	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr3:171404477G>A	uc003fhs.2	-	16	1981	c.1865C>T	c.(1864-1866)GCT>GTT	p.A622V	PLD1_uc003fht.2_Intron	NM_002662	NP_002653	Q13393	PLD1_HUMAN	phospholipase D1 isoform a	622	Catalytic.				cell communication|chemotaxis|Ras protein signal transduction	endoplasmic reticulum membrane|Golgi membrane|late endosome membrane|perinuclear region of cytoplasm	NAPE-specific phospholipase D activity|phosphatidylinositol binding|phospholipase D activity			ovary(2)|lung(1)	3	all_cancers(22;4.53e-19)|Ovarian(172;0.00197)|Breast(254;0.186)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)		Choline(DB00122)	TTACTTACCAGCATGAGGTCT	0.443		NA											17	225					0	0	0	0
PIK3CA	5290	broad.mit.edu	37	3	178936091	178936091	+	Missense_Mutation	SNP	G	G	A	rs104886003		TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr3:178936091G>A	uc003fjk.2	+	10	1790	c.1633G>A	c.(1633-1635)GAG>AAG	p.E545K		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	545	PI3K helical.		E -> G (in KERSEB).|E -> A (in cancer).|E -> K (in KERSEB; shows an increase in lipid kinase activity; oncogenic in vivo; occurs in the interface between the PI3K helical domain and the nSH2 (N-terminal SH2) region of the p85 regulatory subunit and may reduce the inhibitory effect of p85; requires interaction with RAS to induce cellular transformation; enhances invadopodia-mediated extracellular matrix degradation and invasion in breast cancer cells).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.E545K(735)|p.E545A(75)|p.E545G(55)|p.E545?(19)|p.E545D(15)|p.E545Q(12)|p.E545V(4)		breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			TGAAATCACTGAGCAGGAGAA	0.353	E545K(RERFLCSQ1_LUNG)|E545K(KYSE510_OESOPHAGUS)|E545K(NCIH508_LARGE_INTESTINE)|E545K(HCC202_BREAST)|E545K(BFTC909_KIDNEY)|E545K(HCT15_LARGE_INTESTINE)|E545K(NCIH596_LUNG)|E545K(L363_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|E545K(DLD1_LARGE_INTESTINE)|E545K(ESS1_ENDOMETRIUM)|E545K(MDAMB361_BREAST)|E545K(MKN1_STOMACH)|E545K(MCF7_BREAST)|E545K(NCIH460_LUNG)|E545K(TCCSUP_URINARY_TRACT)|E545K(HSC4_UPPER_AERODIGESTIVE_TRACT)|E545K(BC3C_URINARY_TRACT)|E545K(HUH28_BILIARY_TRACT)|E545K(HT1197_URINARY_TRACT)|E545K(TE5_OESOPHAGUS)	57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			6	66					0	0	0	0
ATP13A4	84239	broad.mit.edu	37	3	193175211	193175211	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr3:193175211G>A	uc003ftd.2	-	15	1826	c.1718C>T	c.(1717-1719)CCG>CTG	p.P573L	ATP13A4_uc003fte.1_Missense_Mutation_p.P573L|ATP13A4_uc011bsr.1_Missense_Mutation_p.P44L|ATP13A4_uc010hzi.2_RNA	NM_032279	NP_115655	Q4VNC1	AT134_HUMAN	ATPase type 13A4	573	Extracellular (Potential).				ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			ovary(2)	2	all_cancers(143;1.76e-08)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(49;2.72e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;0.000109)		GGCATGTGCCGGCACTCCCTT	0.458		NA											13	185					0	0	0	0
TNK2	10188	broad.mit.edu	37	3	195608990	195608990	+	Silent	SNP	C	C	T			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr3:195608990C>T	uc003fvu.1	-	6	1362	c.819G>A	c.(817-819)CTG>CTA	p.L273L	TNK2_uc003fvs.1_Silent_p.L305L|TNK2_uc003fvt.1_Silent_p.L336L|TNK2_uc010hzw.1_RNA|TNK2_uc003fvv.1_Silent_p.L103L|TNK2_uc010hzx.1_Intron	NM_005781	NP_005772	Q07912	ACK1_HUMAN	tyrosine kinase, non-receptor, 2 isoform 1	273	Protein kinase.				positive regulation of peptidyl-tyrosine phosphorylation|protein ubiquitination|small GTPase mediated signal transduction	adherens junction|cytoplasmic vesicle membrane|endosome|nucleus	ATP binding|GTPase inhibitor activity|metal ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding			ovary(3)|central_nervous_system(3)|lung(2)|stomach(1)|skin(1)	10	all_cancers(143;6.48e-09)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;1.46e-22)|OV - Ovarian serous cystadenocarcinoma(49;8.3e-19)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;0.000757)	Adenosine triphosphate(DB00171)	GTGCTCGCATCAGCCCAAAGT	0.592		NA											14	110					0	0	0	0
ALB	213	broad.mit.edu	37	4	74274401	74274401	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr4:74274401G>C	uc003hgs.3	+	4	434	c.361G>C	c.(361-363)GAG>CAG	p.E121Q	ALB_uc003hgw.3_Intron|ALB_uc011cbe.1_Intron|ALB_uc003hgt.3_Missense_Mutation_p.E121Q|ALB_uc010iii.2_Intron|ALB_uc003hgu.3_Intron|ALB_uc003hgv.3_Intron|ALB_uc011cbf.1_Missense_Mutation_p.E11Q|ALB_uc010iij.2_RNA|ALB_uc003hgx.3_5'Flank	NM_000477	NP_000468	P02768	ALBU_HUMAN	albumin preproprotein	121	Albumin 1.		E -> G.		bile acid and bile salt transport|bile acid metabolic process|cellular response to starvation|hemolysis by symbiont of host erythrocytes|lipoprotein metabolic process|maintenance of mitochondrion location|negative regulation of apoptosis|platelet activation|platelet degranulation|sodium-independent organic anion transport|transmembrane transport	extracellular space|platelet alpha granule lumen|protein complex	antioxidant activity|chaperone binding|copper ion binding|DNA binding|drug binding|fatty acid binding|pyridoxal phosphate binding|toxin binding			ovary(3)|skin(3)	6	Breast(15;0.00102)		Epithelial(6;4.8e-05)|OV - Ovarian serous cystadenocarcinoma(6;0.000263)|all cancers(17;0.000472)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)		Acenocoumarol(DB01418)|Acitretin(DB00459)|Alfentanil(DB00802)|Aluminium(DB01370)|Auranofin(DB00995)|Bismuth(DB01402)|Captopril(DB01197)|Carboplatin(DB00958)|Cefalotin(DB00456)|Cefazolin(DB01327)|Cefonicid(DB01328)|Cefoperazone(DB01329)|Chlorpheniramine(DB01114)|Chlorpromazine(DB00477)|Ciprofloxacin(DB00537)|Clonazepam(DB01068)|Cloxacillin(DB01147)|Cytarabine(DB00987)|Dantrolene(DB01219)|Diclofenac(DB00586)|Diflunisal(DB00861)|Digitoxin(DB01396)|Estrone(DB00655)|Ethacrynic acid(DB00903)|Etodolac(DB00749)|Flurbiprofen(DB00712)|Gadobenate Dimeglumine(DB00743)|Gatifloxacin(DB01044)|Gliclazide(DB01120)|Halothane(DB01159)|Human Serum Albumin(DB00062)|Hyaluronidase(DB00070)|Ibuprofen(DB01050)|Insulin-detemir(DB01307)|Insulin-glargine(DB01308)|Iodipamide(DB04711)|Ketoprofen(DB01009)|Levamisole(DB00848)|Levothyroxine(DB00451)|Liothyronine(DB00279)|Mefenamic acid(DB00784)|Mephenytoin(DB00532)|Methotrexate(DB00563)|Nortriptyline(DB00540)|Oxazepam(DB00842)|Paclitaxel(DB01229)|Phenprocoumon(DB00946)|Probenecid(DB01032)|Propofol(DB00818)|Pyridoxine(DB00165)|Salicyclic acid(DB00936)|Saquinavir(DB01232)|Serum albumin(DB00096)|Serum albumin iodonated(DB00064)|Sodium lauryl sulfate(DB00815)|Sucralfate(DB00364)|Sulfamethizole(DB00576)|Sulindac(DB00605)|Suprofen(DB00870)|Testosterone(DB00624)|Xanthophyll(DB00137)	ACAAGAACCTGAGAGAAATGA	0.433		NA											7	44					0	0	0	0
GPRIN3	285513	broad.mit.edu	37	4	90171030	90171030	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr4:90171030T>C	uc003hsm.1	-	2	751	c.232A>G	c.(232-234)ATG>GTG	p.M78V		NM_198281	NP_938022	Q6ZVF9	GRIN3_HUMAN	G protein-regulated inducer of neurite outgrowth	78										ovary(3)	3		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;5.67e-05)		GGAGAAGACATATCTGGTTGG	0.582		NA											26	63					0	0	0	0
ZNF827	152485	broad.mit.edu	37	4	146824152	146824152	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr4:146824152C>T	uc003ikn.2	-	2	307	c.259G>A	c.(259-261)GAC>AAC	p.D87N	ZNF827_uc003ikm.2_Missense_Mutation_p.D87N|ZNF827_uc010iox.2_Intron	NM_178835	NP_849157	Q17R98	ZN827_HUMAN	zinc finger protein 827	87					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_hematologic(180;0.151)					ACCTCACTGTCCAGTGCCACC	0.602		NA											8	27					0	0	0	0
PRKAA1	5562	broad.mit.edu	37	5	40798216	40798216	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr5:40798216G>T	uc003jmc.2	-	1	82	c.76C>A	c.(76-78)CAC>AAC	p.H26N	PRKAA1_uc003jmb.2_Missense_Mutation_p.H26N	NM_006251	NP_006242	Q13131	AAPK1_HUMAN	protein kinase, AMP-activated, alpha 1 catalytic	26					activation of MAPK activity|cell cycle arrest|cholesterol biosynthetic process|fatty acid biosynthetic process|insulin receptor signaling pathway|negative regulation of glucosylceramide biosynthetic process|positive regulation of anti-apoptosis|positive regulation of cholesterol biosynthetic process|regulation of fatty acid oxidation|response to hypoxia	cytosol	ATP binding|cAMP-dependent protein kinase activity|metal ion binding|protein binding			breast(1)	1					Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)|Phenformin(DB00914)	AGAATGTAGTGGCCGATCTTC	0.577		NA											5	32					2.01e-06	2.28e-06	1	0
C5orf56	441108	broad.mit.edu	37	5	131822224	131822224	+	Missense_Mutation	SNP	T	T	C	rs9282761	byFrequency	TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr5:131822224T>C	uc010jds.1	+	4	560	c.385T>C	c.(385-387)TCC>CCC	p.S129P	IRF1_uc003kxd.2_Intron|IRF1_uc003kxa.2_Intron|IRF1_uc003kxb.2_Intron|IRF1_uc010jdt.1_Intron			Q8N8D9	CE056_HUMAN	Homo sapiens full length insert cDNA clone ZA99C08.	Error:Variant_position_missing_in_Q8N8D9_after_alignment											0						CTGTGGGGTCTCCTGCCAGAC	0.612		NA											3	17					0	0	0	0
PCDHGC3	5098	broad.mit.edu	37	5	140855927	140855927	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr5:140855927G>C	uc003lkv.1	+	1	359	c.244G>C	c.(244-246)GAG>CAG	p.E82Q	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc003lkh.1_Intron|PCDHGB6_uc003lkj.1_Intron|PCDHGA10_uc003lkl.1_Intron|PCDHGB7_uc003lkn.1_Intron|PCDHGA11_uc003lkp.1_Intron|PCDHGA11_uc003lkq.1_Intron|PCDHGA12_uc003lkt.1_Intron|PCDHGC3_uc003lku.1_Missense_Mutation_p.E82Q|PCDHGC3_uc003lkw.1_Intron	NM_002588	NP_002579	Q9UN70	PCDGK_HUMAN	protocadherin gamma subfamily C, 3 isoform 1	82	Cadherin 1.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(1)|skin(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGTGAACCGGGAGACCGGAGA	0.572		NA											7	120					0	0	0	0
LY6G5C	80741	broad.mit.edu	37	6	31646945	31646945	+	Silent	SNP	G	G	A			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr6:31646945G>A	uc003nvu.1	-	2	213	c.213C>T	c.(211-213)TGC>TGT	p.C71C	LY6G5C_uc003nvw.1_RNA|LY6G5C_uc010jtb.1_RNA	NM_025262	NP_079538	Q5SRR4	LY65C_HUMAN	lymphocyte antigen 6 complex G5C	74	UPAR/Ly6.					extracellular region					0						ATCCCAGAAGGCACCCTAACT	0.542		NA											35	136					0	0	0	0
BAT5	7920	broad.mit.edu	37	6	31655463	31655463	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr6:31655463C>T	uc003nvy.1	-	18	1532	c.1502G>A	c.(1501-1503)CGC>CAC	p.R501H	BAT5_uc003nvx.1_Missense_Mutation_p.R282H|BAT5_uc011dny.1_Missense_Mutation_p.R468H|BAT5_uc003nvz.1_Missense_Mutation_p.R282H|BAT5_uc011dnz.1_Missense_Mutation_p.R282H	NM_021160	NP_066983	O95870	ABHGA_HUMAN	HLA-B associated transcript 5	501						integral to membrane	hydrolase activity|protein binding				0						CTGGTAGGAGCGGAGGACAGA	0.597		NA											8	43					0	0	0	0
TNXB	7148	broad.mit.edu	37	6	32016196	32016196	+	Missense_Mutation	SNP	A	A	T			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr6:32016196A>T	uc003nzl.2	-	29	10185	c.9983T>A	c.(9982-9984)CTC>CAC	p.L3328H	TNXB_uc003nzg.1_5'Flank|TNXB_uc003nzh.1_5'Flank	NM_019105	NP_061978	P22105	TENX_HUMAN	tenascin XB isoform 1 precursor	3375	Fibronectin type-III 25.				actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding				0						GAGTCCAAAGAGCAGGAACTT	0.701		NA											6	31					0	0	0	0
TNXB	7148	broad.mit.edu	37	6	32017777	32017777	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr6:32017777G>A	uc003nzl.2	-	27	9633	c.9431C>T	c.(9430-9432)ACG>ATG	p.T3144M		NM_019105	NP_061978	P22105	TENX_HUMAN	tenascin XB isoform 1 precursor	3191					actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding				0						TCACTCACCCGTCACCCCAAT	0.602		NA											8	83					0	0	0	0
LAMA4	3910	broad.mit.edu	37	6	112510392	112510392	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr6:112510392C>T	uc003pvu.2	-	7	1043	c.734G>A	c.(733-735)GGA>GAA	p.G245E	LAMA4_uc003pvv.2_Missense_Mutation_p.G245E|LAMA4_uc003pvt.2_Missense_Mutation_p.G245E	NM_001105206	NP_001098676	Q16363	LAMA4_HUMAN	laminin, alpha 4 isoform 1 precursor	245	Laminin EGF-like 4; truncated.				cell adhesion|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	extracellular matrix structural constituent|receptor binding			ovary(4)|breast(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	9		all_cancers(87;0.000196)|all_hematologic(75;0.000114)|all_epithelial(87;0.00542)|Colorectal(196;0.0209)		all cancers(137;0.0335)|OV - Ovarian serous cystadenocarcinoma(136;0.0578)|Epithelial(106;0.0748)|BRCA - Breast invasive adenocarcinoma(108;0.242)		ACATGGGCCTCCCCCGCAGTT	0.428		NA											5	28					0	0	0	0
RGS17	26575	broad.mit.edu	37	6	153365099	153365099	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr6:153365099G>A	uc003qpm.2	-	2	211	c.55C>T	c.(55-57)CCT>TCT	p.P19S		NM_012419	NP_036551	Q9UGC6	RGS17_HUMAN	regulator of G-protein signalling 17	19					negative regulation of signal transduction	cytoplasm|nucleus|plasma membrane	GTPase activator activity|signal transducer activity			pancreas(1)	1		Ovarian(120;0.126)		OV - Ovarian serous cystadenocarcinoma(155;1.09e-09)|BRCA - Breast invasive adenocarcinoma(81;0.0429)		TGGTTTCCAGGAGCTTGAGAC	0.493		NA							Lung_Cancer_Familial_Clustering_of				7	149					0	0	0	0
HOXA1	3198	broad.mit.edu	37	7	27135348	27135348	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr7:27135348C>T	uc003sye.2	-	1	278	c.184G>A	c.(184-186)GGT>AGT	p.G62S	HOXA1_uc003syd.2_Missense_Mutation_p.G62S|uc003syg.2_5'Flank	NM_005522	NP_005513	P49639	HXA1_HUMAN	homeobox A1 isoform a	62						nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(3)	3						tggGGCGAACCGATCTGCACC	0.522		NA									OREG0003750	type=REGULATORY REGION|Gene=BC031342|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	7	32					0	0	0	0
HECW1	23072	broad.mit.edu	37	7	43519316	43519316	+	Silent	SNP	G	G	A			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr7:43519316G>A	uc003tid.1	+	17	3812	c.3207G>A	c.(3205-3207)CAG>CAA	p.Q1069Q	HECW1_uc011kbi.1_Silent_p.Q1035Q	NM_015052	NP_055867	Q76N89	HECW1_HUMAN	NEDD4-like ubiquitin-protein ligase 1	1069					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	ubiquitin-protein ligase activity			ovary(8)|lung(6)|breast(4)|skin(4)|pancreas(1)	23						AGCACCTCCAGAGGCTCCGAA	0.557		NA											7	120					0	0	0	0
MGC26647	219557	broad.mit.edu	37	7	88423630	88423630	+	Silent	SNP	G	G	C			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr7:88423630G>C	uc003ujv.2	-	2	809	c.627C>G	c.(625-627)CTC>CTG	p.L209L	ZNF804B_uc011khi.1_Intron	NM_152706	NP_689919	Q8TBZ9	CG062_HUMAN	hypothetical protein LOC219557	209											0	Esophageal squamous(14;0.00802)|all_hematologic(106;0.109)|Lung NSC(181;0.168)|all_lung(186;0.169)		STAD - Stomach adenocarcinoma(171;0.229)			TTTGTTCTGGGAGGAGTAGGT	0.413		NA											13	73					0	0	0	0
SLC26A3	1811	broad.mit.edu	37	7	107432371	107432371	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr7:107432371G>C	uc003ver.2	-	4	497	c.286C>G	c.(286-288)CTG>GTG	p.L96V	SLC26A3_uc003ves.2_Missense_Mutation_p.L61V	NM_000111	NP_000102	P40879	S26A3_HUMAN	solute carrier family 26, member 3	96	Helical; (Potential).				excretion	integral to membrane|membrane fraction	inorganic anion exchanger activity|secondary active sulfate transmembrane transporter activity|sequence-specific DNA binding transcription factor activity|transcription cofactor activity			ovary(3)|skin(1)	4						TCGACCAGCAGAGCAAATGCT	0.438		NA											3	39					0	0	0	0
TRPV6	55503	broad.mit.edu	37	7	142569516	142569516	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr7:142569516G>A	uc003wbx.1	-	15	2338	c.2122C>T	c.(2122-2124)CGT>TGT	p.R708C	TRPV6_uc003wbw.1_Missense_Mutation_p.R494C|TRPV6_uc010lou.1_Missense_Mutation_p.R579C	NM_018646	NP_061116	Q9H1D0	TRPV6_HUMAN	transient receptor potential cation channel,	708	Interaction with calmodulin.|Cytoplasmic (Potential).				regulation of calcium ion-dependent exocytosis	integral to plasma membrane	calcium channel activity|calmodulin binding			ovary(2)	2	Melanoma(164;0.059)					ATTATCCCACGCAGGTCTCTC	0.567		NA											8	62					0	0	0	0
CHD7	55636	broad.mit.edu	37	8	61764696	61764696	+	Silent	SNP	G	G	A			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr8:61764696G>A	uc003xue.2	+	29	6261	c.5784G>A	c.(5782-5784)CAG>CAA	p.Q1928Q		NM_017780	NP_060250	Q9P2D1	CHD7_HUMAN	chromodomain helicase DNA binding protein 7	1928					central nervous system development|chromatin modification|cognition|cranial nerve development|face development|heart morphogenesis|in utero embryonic development|inner ear morphogenesis|nose development|palate development|regulation of growth hormone secretion|regulation of transcription, DNA-dependent|retina development in camera-type eye|skeletal system development|T cell differentiation|transcription, DNA-dependent	nucleus	ATP binding|chromatin binding|DNA binding|helicase activity			ovary(4)|large_intestine(1)|central_nervous_system(1)|lung(1)|breast(1)|pancreas(1)	9		all_cancers(86;0.2)|all_lung(136;0.0402)|Lung NSC(129;0.0459)|all_epithelial(80;0.0477)	BRCA - Breast invasive adenocarcinoma(89;0.143)			AAAGGCAACAGATGAGGCAAG	0.527		NA											7	41					0	0	0	0
CHMP4C	92421	broad.mit.edu	37	8	82670413	82670413	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr8:82670413G>A	uc003ycl.2	+	4	694	c.520G>A	c.(520-522)GAG>AAG	p.E174K		NM_152284	NP_689497	Q96CF2	CHM4C_HUMAN	chromatin modifying protein 4C	174	Potential.|Intramolecular interaction with N- terminus (By similarity).				cellular membrane organization|endosome transport|protein transport	cytosol|late endosome membrane	protein binding			ovary(2)	2						ATTGGAACAGGAGGAATTAAA	0.433		NA											4	52					0	0	0	0
TRPS1	7227	broad.mit.edu	37	8	116426463	116426463	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr8:116426463C>T	uc003ynz.2	-	6	4093	c.3634G>A	c.(3634-3636)GAA>AAA	p.E1212K	TRPS1_uc011lhy.1_Missense_Mutation_p.E1216K|TRPS1_uc003yny.2_Missense_Mutation_p.E1225K|TRPS1_uc010mcy.2_Missense_Mutation_p.E1212K	NM_014112	NP_054831	Q9UHF7	TRPS1_HUMAN	zinc finger transcription factor TRPS1	1212	Transcriptional repressor domain (By similarity).				negative regulation of transcription from RNA polymerase II promoter|NLS-bearing substrate import into nucleus|regulation of chondrocyte differentiation|skeletal system development|transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)|skin(2)|pancreas(1)|lung(1)|kidney(1)	7	all_cancers(13;5.44e-23)|all_epithelial(1;2.14e-27)|Lung NSC(37;2.55e-05)|Ovarian(258;0.0219)		Epithelial(1;9.78e-37)|all cancers(1;3.14e-31)|BRCA - Breast invasive adenocarcinoma(1;2.56e-12)			GTTGAAAGTTCATCTTGAGTA	0.418		NA							Langer-Giedion_syndrome				12	62					0	0	0	0
TTC39B	158219	broad.mit.edu	37	9	15214144	15214144	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr9:15214144G>A	uc003zlr.1	-	4	398	c.277C>T	c.(277-279)CGC>TGC	p.R93C	TTC39B_uc003zlq.1_Missense_Mutation_p.R62C|TTC39B_uc011lmp.1_5'UTR|TTC39B_uc010mie.1_Missense_Mutation_p.R93C|TTC39B_uc011lmq.1_Missense_Mutation_p.R93C|TTC39B_uc011lmr.1_Intron|TTC39B_uc010mif.1_Missense_Mutation_p.R93C|TTC39B_uc003zls.1_5'UTR|TTC39B_uc010mig.1_Missense_Mutation_p.R62C|TTC39B_uc011lms.1_RNA	NM_152574	NP_689787	Q5VTQ0	TT39B_HUMAN	tetratricopeptide repeat domain 39B	93							binding			ovary(1)	1						TACCAGGGGCGAAGCAATTCT	0.368		NA											17	43					0	0	0	0
CEP78	84131	broad.mit.edu	37	9	80856706	80856706	+	Silent	SNP	G	G	A			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr9:80856706G>A	uc004akx.2	+	4	870	c.594G>A	c.(592-594)AAG>AAA	p.K198K	CEP78_uc004aky.3_Silent_p.K198K|CEP78_uc010mpp.2_Silent_p.K198K|CEP78_uc011lsp.1_Silent_p.K111K	NM_032171	NP_115547	Q5JTW2	CEP78_HUMAN	centrosomal protein 78kDa isoform b	198					G2/M transition of mitotic cell cycle	centrosome|cytosol				ovary(1)	1						ACATGGCCAAGATCTTAAAGG	0.343		NA											13	38					0	0	0	0
EGFL6	25975	broad.mit.edu	37	X	13645320	13645320	+	Silent	SNP	G	G	A			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chrX:13645320G>A	uc004cvi.2	+	11	1716	c.1476G>A	c.(1474-1476)GAG>GAA	p.E492E	EGFL6_uc004cvj.2_Silent_p.E493E	NM_015507	NP_056322	Q8IUX8	EGFL6_HUMAN	epidermal growth factor-like protein 6	492	MAM.				cell adhesion|cell cycle|cell differentiation|multicellular organismal development	basement membrane|extracellular space|membrane	calcium ion binding|integrin binding			breast(2)	2						TGGCATGGGAGAAGACCACGA	0.433		NA											6	58					0	0	0	0
ZMYM3	9203	broad.mit.edu	37	X	70470533	70470533	+	Silent	SNP	G	G	A			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chrX:70470533G>A	uc004dzh.1	-	5	909	c.822C>T	c.(820-822)CCC>CCT	p.P274P	BCYRN1_uc011mpt.1_Intron|ZMYM3_uc004dzi.1_Silent_p.P274P|ZMYM3_uc004dzj.1_Silent_p.P274P|ZMYM3_uc011mpu.1_Silent_p.P5P|ZMYM3_uc004dzk.3_Silent_p.P274P|ZMYM3_uc004dzl.3_Silent_p.P274P|ZMYM3_uc004dzm.3_Silent_p.P274P	NM_201599	NP_963893	Q14202	ZMYM3_HUMAN	zinc finger protein 261	274					multicellular organismal development	nucleus	DNA binding|zinc ion binding			ovary(1)	1	Renal(35;0.156)					CCTCATCATTGGGGTCATCTA	0.572		NA											4	3					0	0	0	0
PCDH19	57526	broad.mit.edu	37	X	99657583	99657583	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chrX:99657583G>C	uc010nmz.2	-	3	4231	c.2555C>G	c.(2554-2556)TCT>TGT	p.S852C	PCDH19_uc004efw.3_Missense_Mutation_p.S805C|PCDH19_uc004efx.3_Missense_Mutation_p.S805C	NM_020766	NP_001098713	Q8TAB3	PCD19_HUMAN	protocadherin 19 isoform b	852	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)|breast(2)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	7						GCTGTTGAAAGAGTGATGGTA	0.577		NA											3	9					0	0	0	0
BEX4	56271	broad.mit.edu	37	X	102471381	102471381	+	Silent	SNP	G	G	A			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chrX:102471381G>A	uc004ejv.3	+	3	535	c.300G>A	c.(298-300)AGG>AGA	p.R100R	BEX4_uc004ejw.3_Silent_p.R100R	NM_001080425	NP_001073894	Q9NWD9	BEX4_HUMAN	BEX family member 4	100						cytoplasm|nucleus				skin(1)	1						AGCAGATGAGGCACTATATGC	0.418		NA											6	59					0	0	0	0
GUCY2F	2986	broad.mit.edu	37	X	108691319	108691319	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chrX:108691319G>C	uc004eod.3	-	6	1824	c.1548C>G	c.(1546-1548)ATC>ATG	p.I516M	GUCY2F_uc011msq.1_RNA	NM_001522	NP_001513	P51841	GUC2F_HUMAN	guanylate cyclase 2F precursor	516	Cytoplasmic (Potential).				intracellular signal transduction|receptor guanylyl cyclase signaling pathway|visual perception	integral to plasma membrane|nuclear outer membrane	ATP binding|GTP binding|guanylate cyclase activity|protein kinase activity|receptor activity			lung(4)|breast(3)|central_nervous_system(1)	8						AGTGGGGATTGATAAACGTTA	0.279		NA											14	24					0	0	0	0
PGRMC1	10857	broad.mit.edu	37	X	118370416	118370416	+	Silent	SNP	C	C	T			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chrX:118370416C>T	uc004erb.2	+	1	206	c.90C>T	c.(88-90)CTC>CTT	p.L30L	PGRMC1_uc011mts.1_Silent_p.L30L	NM_006667	NP_006658	O00264	PGRC1_HUMAN	progesterone receptor membrane component 1	30	Helical; (Potential).					cell surface|endoplasmic reticulum membrane|integral to membrane|microsome|nucleolus	heme binding|protein binding|receptor activity|steroid binding				0						CGTCGCCGCTCAACCTGCTGC	0.667		NA											11	4					0	0	0	0
CXorf66	347487	broad.mit.edu	37	X	139038791	139038792	+	Missense_Mutation	DNP	TC	TC	AA			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chrX:139038791_139038792TC>AA	uc004fbb.2	-	3	371_372	c.349_350GA>TT	c.(349-351)GAC>TTC	p.D117F		NM_001013403	NP_001013421	Q5JRM2	CX066_HUMAN	hypothetical protein LOC347487 precursor	117	Ser-rich.|Cytoplasmic (Potential).					integral to membrane					0						AGATGACTTGTCTGCAGTAGAT	0.441		NA											10	60					0	0	0	0
SLITRK4	139065	broad.mit.edu	37	X	142716823	142716823	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chrX:142716823C>A	uc004fbx.2	-	2	2478	c.2102G>T	c.(2101-2103)GGC>GTC	p.G701V	SLITRK4_uc004fby.2_Missense_Mutation_p.G701V	NM_173078	NP_775101	Q8IW52	SLIK4_HUMAN	slit and trk like 4 protein precursor	701	Cytoplasmic (Potential).					integral to membrane				upper_aerodigestive_tract(1)|large_intestine(1)	2	Acute lymphoblastic leukemia(192;6.56e-05)					CTCTTTCAAGCCACAAGTGTG	0.403		NA											22	67					2.89e-11	3.3e-11	1	0
PLXNB3	5365	broad.mit.edu	37	X	153043515	153043515	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chrX:153043515G>A	uc004fii.2	+	32	5548	c.5374G>A	c.(5374-5376)GAC>AAC	p.D1792N	PLXNB3_uc010nuk.2_Missense_Mutation_p.D1815N|PLXNB3_uc011mzd.1_Missense_Mutation_p.D1431N|SRPK3_uc004fik.2_5'UTR|SRPK3_uc010nul.2_5'Flank|SRPK3_uc004fin.2_5'Flank|SRPK3_uc004fil.2_5'Flank|SRPK3_uc004fim.2_5'Flank	NM_005393	NP_005384	Q9ULL4	PLXB3_HUMAN	plexin B3 isoform 1	1792	Cytoplasmic (Potential).				axon guidance	integral to membrane|intracellular|plasma membrane	protein binding|receptor activity			lung(1)	1	all_hematologic(71;4.25e-06)|all_lung(58;3.83e-05)|Lung NSC(58;5.54e-05)|Acute lymphoblastic leukemia(192;6.56e-05)					GACCTTCATTGACTCCTGTAC	0.572		NA											13	18					0	0	0	0
B2M	567	broad.mit.edu	37	15	45007775	45007775	+	Frame_Shift_Del	DEL	G	G	-			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr15:45007775delG	uc001zuc.2	+	2	282	c.222delG	c.(220-222)TTGfs	p.L74fs	B2M_uc010uek.1_Frame_Shift_Del_p.L74fs|B2M_uc010bdx.1_Intron	NM_004048	NP_004039	P61769	B2MG_HUMAN	beta-2-microglobulin precursor	74	Ig-like C1-type.				antigen processing and presentation of peptide antigen via MHC class I|interferon-gamma-mediated signaling pathway|regulation of defense response to virus by virus|viral reproduction	early endosome membrane|Golgi membrane|MHC class I protein complex	protein binding			ovary(2)|skin(1)	3		all_cancers(109;1.88e-13)|all_epithelial(112;2.13e-11)|Lung NSC(122;2.22e-07)|all_lung(180;1.81e-06)|Melanoma(134;0.0122)		all cancers(107;4.16e-21)|GBM - Glioblastoma multiforme(94;8.97e-07)|COAD - Colon adenocarcinoma(120;0.0357)|Colorectal(105;0.0377)|Lung(196;0.0903)|LUSC - Lung squamous cell carcinoma(244;0.192)		ATTCAGACTTGTCTTTCAGCA	0.418		NA											8	131	---	---	---	---	NA	NA	NA	NA
ZNF750	79755	broad.mit.edu	37	17	80790043	80790044	+	Frame_Shift_Del	DEL	AG	AG	-			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr17:80790043_80790044delAG	uc002kga.2	-	2	598_599	c.287_288delCT	c.(286-288)TCTfs	p.S96fs	TBCD_uc002kfx.1_Intron|TBCD_uc002kfy.1_Intron|TBCD_uc002kfz.2_Intron	NM_024702	NP_078978	Q32MQ0	ZN750_HUMAN	zinc finger protein 750	96						intracellular	zinc ion binding			central_nervous_system(1)	1	Breast(20;0.000523)|all_neural(118;0.0779)	all_cancers(8;0.0514)|all_epithelial(8;0.0748)	OV - Ovarian serous cystadenocarcinoma(97;0.0868)|BRCA - Breast invasive adenocarcinoma(99;0.149)			AGTCGAAGGCAGAGAGTCCATT	0.574		NA											11	66	---	---	---	---	NA	NA	NA	NA
NIPBL	25836	broad.mit.edu	37	5	37064919	37064929	+	Frame_Shift_Del	DEL	TGCTAATAAGC	TGCTAATAAGC	-			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr5:37064919_37064929delTGCTAATAAGC	uc003jkl.3	+	47	8839_8849	c.8340_8350delTGCTAATAAGC	c.(8338-8352)AGTGCTAATAAGCTGfs	p.S2780fs	NIPBL_uc003jkk.3_3'UTR|NIPBL_uc003jkn.2_3'UTR	NM_133433	NP_597677	Q6KC79	NIPBL_HUMAN	delangin isoform A	2780_2784					brain development|cellular protein localization|cellular response to X-ray|cognition|developmental growth|ear morphogenesis|embryonic arm morphogenesis|embryonic digestive tract morphogenesis|external genitalia morphogenesis|eye morphogenesis|face morphogenesis|gall bladder development|maintenance of mitotic sister chromatid cohesion|metanephros development|negative regulation of transcription from RNA polymerase II promoter|outflow tract morphogenesis|positive regulation of histone deacetylation|regulation of developmental growth|regulation of embryonic development|regulation of hair cycle|response to DNA damage stimulus|sensory perception of sound|uterus morphogenesis	SMC loading complex	chromo shadow domain binding|histone deacetylase binding|protein C-terminus binding|protein N-terminus binding			ovary(4)|lung(2)|large_intestine(1)|breast(1)|kidney(1)	9	all_lung(31;0.000447)|Hepatocellular(1;0.108)		Epithelial(62;0.072)|COAD - Colon adenocarcinoma(61;0.14)|all cancers(62;0.191)|Colorectal(62;0.202)			CTCTAACGAGTGCTAATAAGCTGACTAATAA	0.427		NA											14	62	---	---	---	---	NA	NA	NA	NA
MAPK15	225689	broad.mit.edu	37	8	144803822	144803823	+	Frame_Shift_Ins	INS	-	-	C			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr8:144803822_144803823insC	uc003yzj.2	+	12	1349_1350	c.1308_1309insC	c.(1306-1311)GCGCCCfs	p.A436fs		NM_139021	NP_620590	Q8TD08	MK15_HUMAN	mitogen-activated protein kinase 15	436_437					protein autophosphorylation	extracellular region	ATP binding|MAP kinase activity|SH3 domain binding			lung(2)	2	all_cancers(97;3.74e-11)|all_epithelial(106;2.62e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;3.38e-41)|Epithelial(56;6.8e-40)|all cancers(56;6.43e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.146)			CGAAGGAAGCGCCCCCCTTGAC	0.644		NA											7	135	---	---	---	---	NA	NA	NA	NA