Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	isArtifactMode	oxoGCut
GRIK3	2899	broad.mit.edu	37	1	37337827	37337827	+	Missense_Mutation	SNP	C	C	T	rs143358361		TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr1:37337827C>T	uc001caz.2	-	4	829	c.694G>A	c.(694-696)GAC>AAC	p.D232N	GRIK3_uc001cba.1_Missense_Mutation_p.D232N	NM_000831	NP_000822	Q13003	GRIK3_HUMAN	glutamate receptor, ionotropic, kainate 3	232	Extracellular (Potential).				negative regulation of synaptic transmission, glutamatergic|regulation of membrane potential|synaptic transmission	cell junction|dendrite cytoplasm|integral to plasma membrane|perikaryon|postsynaptic membrane|terminal button	adenylate cyclase inhibiting metabotropic glutamate receptor activity|extracellular-glutamate-gated ion channel activity|G-protein-coupled receptor binding|kainate selective glutamate receptor activity	p.D232N(1)		ovary(3)|skin(2)|large_intestine(1)|breast(1)	7		Myeloproliferative disorder(586;0.0258)|all_neural(195;0.169)			L-Glutamic Acid(DB00142)	TGGCTGCAGTCGAAGATAATG	0.612		NA											4	22					0	0	0	0
MACF1	23499	broad.mit.edu	37	1	39797559	39797559	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr1:39797559G>A	uc010oiu.1	+	1	750	c.619G>A	c.(619-621)GAA>AAA	p.E207K	MACF1_uc010ois.1_Intron|MACF1_uc001cda.1_Intron|MACF1_uc001cdc.1_Intron|MACF1_uc001cdb.1_Intron	NM_033044	NP_149033	Q9UPN3	MACF1_HUMAN	microfilament and actin filament cross-linker	1772	Plectin 3.				cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			ovary(8)|breast(3)|central_nervous_system(3)|skin(2)	16	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			CCGGTTGCTGGAAGCTCAGCT	0.498		NA											11	35					0	0	0	0
FOXE3	2301	broad.mit.edu	37	1	47882290	47882290	+	Silent	SNP	C	C	T			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr1:47882290C>T	uc001crk.2	+	1	547	c.303C>T	c.(301-303)ATC>ATT	p.I101I		NM_012186	NP_036318	Q13461	FOXE3_HUMAN	forkhead box E3	101	Fork-head.				cell migration|embryonic organ morphogenesis|enteric nervous system development|hair follicle morphogenesis|hard palate development|lens morphogenesis in camera-type eye|pattern specification process|positive regulation of epithelial cell proliferation|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity|soft palate development|thyroid gland development|thyroid hormone generation	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding				0				READ - Rectum adenocarcinoma(2;0.0908)		ACCGCTTCATCACCGAACGCT	0.667		NA											9	20					0	0	0	0
WDR47	22911	broad.mit.edu	37	1	109554140	109554140	+	Silent	SNP	G	G	T			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr1:109554140G>T	uc001dwj.2	-	5	904	c.528C>A	c.(526-528)ATC>ATA	p.I176I	WDR47_uc001dwl.2_Silent_p.I183I|WDR47_uc001dwi.2_Silent_p.I176I|WDR47_uc001dwk.2_Silent_p.I148I|WDR47_uc010ovf.1_Silent_p.I103I	NM_001142551	NP_001136023	O94967	WDR47_HUMAN	WD repeat domain 47 isoform 3	176										ovary(1)	1		all_lung(203;0.00519)|all_epithelial(167;0.00611)|Lung NSC(277;0.00822)		Colorectal(144;0.0165)|Lung(183;0.0484)|COAD - Colon adenocarcinoma(174;0.128)|Epithelial(280;0.168)|all cancers(265;0.201)|LUSC - Lung squamous cell carcinoma(189;0.244)		TATCAGCAGGGATGAATTCTG	0.443		NA											42	100					6.46e-13	7.46e-13	1	0
NUP210L	91181	broad.mit.edu	37	1	154067493	154067493	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr1:154067493C>G	uc001fdw.2	-	15	2177	c.2105G>C	c.(2104-2106)GGA>GCA	p.G702A	NUP210L_uc009woq.2_5'UTR|NUP210L_uc010peh.1_Missense_Mutation_p.G702A	NM_207308	NP_997191	Q5VU65	P210L_HUMAN	nucleoporin 210kDa-like isoform 1	702						integral to membrane				skin(5)|ovary(4)|large_intestine(1)|central_nervous_system(1)	11	all_lung(78;9.35e-31)|Lung NSC(65;1.33e-28)|Hepatocellular(266;0.0877)|Melanoma(130;0.128)		LUSC - Lung squamous cell carcinoma(543;0.151)|Colorectal(543;0.198)			TTGTGCTATTCCAATCTTCTC	0.443		NA											10	28					0	0	0	0
C1orf189	388701	broad.mit.edu	37	1	154171936	154171936	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr1:154171936C>G	uc001fee.1	-	4	299	c.273G>C	c.(271-273)CAG>CAC	p.Q91H		NM_001010979	NP_001010979	Q5VU69	CA189_HUMAN	hypothetical protein LOC388701	91											0	all_lung(78;9.35e-31)|Lung NSC(65;1.33e-28)|Hepatocellular(266;0.0877)|Melanoma(130;0.128)					CTTTGCCCATCTGATTTAGTT	0.478		NA											42	221					0	0	0	0
PEAR1	375033	broad.mit.edu	37	1	156884446	156884446	+	Silent	SNP	C	C	T			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr1:156884446C>T	uc001fqj.1	+	23	3086	c.2970C>T	c.(2968-2970)GAC>GAT	p.D990D	PEAR1_uc001fqk.1_Silent_p.D615D	NM_001080471	NP_001073940	Q5VY43	PEAR1_HUMAN	platelet endothelial aggregation receptor 1	990	Pro-rich.					integral to membrane				ovary(2)|central_nervous_system(1)	3	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					CAGACCGAGACTCTGTGGGCT	0.607		NA											22	65					0	0	0	0
FCRL3	115352	broad.mit.edu	37	1	157666929	157666929	+	Splice_Site	SNP	C	C	G			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr1:157666929C>G	uc001frb.2	-	6	1136	c.844_splice	c.e6+1	p.R282_splice	FCRL3_uc001fqx.3_Splice_Site|FCRL3_uc001fqy.3_Splice_Site|FCRL3_uc001fqz.3_Splice_Site_p.R282_splice|FCRL3_uc009wsn.2_Intron|FCRL3_uc009wso.2_Splice_Site|FCRL3_uc001fra.2_5'UTR|FCRL3_uc001frc.1_Splice_Site_p.R282_splice	NM_052939	NP_443171	Q96P31	FCRL3_HUMAN	Fc receptor-like 3 precursor							integral to membrane|plasma membrane	receptor activity			ovary(3)|breast(1)	4	all_hematologic(112;0.0378)					TAGACACTCACTCTGTACACG	0.522		NA											17	24					0	0	0	0
FCGR3A	2214	broad.mit.edu	37	1	161518211	161518211	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr1:161518211C>T	uc001gat.3	-	4	456	c.319G>A	c.(319-321)GGC>AGC	p.G107S	FCGR3A_uc001gar.2_Missense_Mutation_p.G143S|FCGR3A_uc001gas.2_Missense_Mutation_p.G142S|FCGR3A_uc009wuh.2_Missense_Mutation_p.G106S|FCGR3A_uc009wui.2_Missense_Mutation_p.G107S	NM_001127595	NP_001121067	P08637	FCG3A_HUMAN	Fc fragment of IgG, low affinity IIIa, receptor	107	Extracellular (Potential).|Ig-like C2-type 2.				immune response|regulation of immune response	extracellular region|integral to membrane|plasma membrane	IgG binding|receptor activity			ovary(1)	1	all_cancers(52;4.89e-16)|all_hematologic(112;0.0207)		BRCA - Breast invasive adenocarcinoma(70;0.00376)		Abciximab(DB00054)|Adalimumab(DB00051)|Alefacept(DB00092)|Alemtuzumab(DB00087)|Basiliximab(DB00074)|Bevacizumab(DB00112)|Cetuximab(DB00002)|Daclizumab(DB00111)|Efalizumab(DB00095)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Natalizumab(DB00108)|Palivizumab(DB00110)|Rituximab(DB00073)|Tositumomab(DB00081)|Trastuzumab(DB00072)	ATCAACTCACCGATATGGACT	0.473		NA											4	59					0	0	0	0
FCGR3B	2215	broad.mit.edu	37	1	161599568	161599568	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr1:161599568C>T	uc009wul.2	-	3	593	c.319G>A	c.(319-321)GGC>AGC	p.G107S		NM_000570	NP_000561	O75015	FCG3B_HUMAN	low affinity immunoglobulin gamma Fc region	107					immune response	anchored to membrane|extracellular region|plasma membrane	IgG binding|receptor activity				0	all_cancers(52;4.89e-16)|all_hematologic(112;0.0207)		BRCA - Breast invasive adenocarcinoma(70;0.00376)		Abciximab(DB00054)|Adalimumab(DB00051)|Alefacept(DB00092)|Alemtuzumab(DB00087)|Basiliximab(DB00074)|Bevacizumab(DB00112)|Cetuximab(DB00002)|Daclizumab(DB00111)|Efalizumab(DB00095)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Natalizumab(DB00108)|Palivizumab(DB00110)|Rituximab(DB00073)|Tositumomab(DB00081)|Trastuzumab(DB00072)	ATCAACTCACCGATATGGACT	0.468		NA											6	40					0	0	0	0
MPZL1	9019	broad.mit.edu	37	1	167757121	167757121	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr1:167757121C>T	uc001geo.2	+	6	975	c.773C>T	c.(772-774)TCA>TTA	p.S258L	MPZL1_uc001gep.2_3'UTR|MPZL1_uc001geq.2_Missense_Mutation_p.S108L|MPZL1_uc009wvh.2_RNA	NM_003953	NP_003944	O95297	MPZL1_HUMAN	myelin protein zero-like 1 isoform a	258	Cytoplasmic (Potential).				cell-cell signaling|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	protein binding|structural molecule activity			ovary(2)	2	all_hematologic(923;0.215)					ATTAACAAGTCAGAGTCTGTG	0.438		NA											24	30					0	0	0	0
BAT2L2	23215	broad.mit.edu	37	1	171509614	171509614	+	Silent	SNP	A	A	G			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr1:171509614A>G	uc010pmg.1	+	16	3269	c.3003A>G	c.(3001-3003)AGA>AGG	p.R1001R	BAT2L2_uc010pmh.1_5'UTR	NM_015172	NP_055987	Q9Y520	PRC2C_HUMAN	HBxAg transactivated protein 2	1001							protein C-terminus binding				0						GCTCTAACAGAAGGGAAGAAG	0.403		NA											6	14					0	0	0	0
CACYBP	27101	broad.mit.edu	37	1	174977767	174977767	+	Missense_Mutation	SNP	T	T	C			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr1:174977767T>C	uc001gkj.1	+	5	880	c.455T>C	c.(454-456)ATA>ACA	p.I152T	CACYBP_uc001gki.1_Missense_Mutation_p.I109T	NM_014412	NP_055227	Q9HB71	CYBP_HUMAN	calcyclin binding protein isoform 1	152	Interaction with SKP1.|CS.					beta-catenin destruction complex	protein homodimerization activity				0						ACAGTTCTTATATTGTGTAGA	0.333		NA											51	36					0	0	0	0
PAPPA2	60676	broad.mit.edu	37	1	176668354	176668354	+	Silent	SNP	G	G	T			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr1:176668354G>T	uc001gkz.2	+	8	4029	c.2865G>T	c.(2863-2865)CTG>CTT	p.L955L	PAPPA2_uc009www.2_RNA	NM_020318	NP_064714	Q9BXP8	PAPP2_HUMAN	pappalysin 2 isoform 1	955					cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			ovary(7)|central_nervous_system(5)|skin(2)|lung(1)|breast(1)	16						GCTTGGAGCTGCTCTTCCAAC	0.592		NA											25	126					2.8e-10	3.17e-10	1	0
PAPPA2	60676	broad.mit.edu	37	1	176769219	176769219	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr1:176769219G>A	uc001gkz.2	+	21	6317	c.5153G>A	c.(5152-5154)CGT>CAT	p.R1718H	PAPPA2_uc009www.2_RNA	NM_020318	NP_064714	Q9BXP8	PAPP2_HUMAN	pappalysin 2 isoform 1	1718	Sushi 5.				cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			ovary(7)|central_nervous_system(5)|skin(2)|lung(1)|breast(1)	16						ACTGGCCGGCGTCAATGGCAC	0.493		NA											25	86					0	0	0	0
QSOX1	5768	broad.mit.edu	37	1	180165521	180165521	+	Silent	SNP	C	C	G			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr1:180165521C>G	uc001gnz.2	+	12	1668	c.1593C>G	c.(1591-1593)CTC>CTG	p.L531L	QSOX1_uc001gny.2_Silent_p.L531L|QSOX1_uc001goa.2_Silent_p.L531L|QSOX1_uc001goc.2_Silent_p.L73L|FLJ23867_uc001god.3_5'Flank	NM_002826	NP_002817	O00391	QSOX1_HUMAN	quiescin Q6 sulfhydryl oxidase 1 isoform a	531					cell redox homeostasis|protein thiol-disulfide exchange	extracellular space|integral to Golgi membrane	flavin-linked sulfhydryl oxidase activity			ovary(1)|central_nervous_system(1)	2						TCAACTTCCTCAAGGCCCACT	0.617		NA											62	140					0	0	0	0
ASPM	259266	broad.mit.edu	37	1	197071233	197071233	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr1:197071233C>G	uc001gtu.2	-	18	7405	c.7148G>C	c.(7147-7149)AGA>ACA	p.R2383T	ASPM_uc001gtv.2_Intron|ASPM_uc001gtw.3_Missense_Mutation_p.R231T	NM_018136	NP_060606	Q8IZT6	ASPM_HUMAN	asp (abnormal spindle)-like, microcephaly	2383					mitosis	cytoplasm|nucleus	calmodulin binding			ovary(4)|central_nervous_system(2)	6						GTGTCTTTGTCTGAGATAATG	0.433		NA											37	151					0	0	0	0
PTPN14	5784	broad.mit.edu	37	1	214542824	214542824	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr1:214542824G>C	uc001hkk.1	-	17	3518	c.3247C>G	c.(3247-3249)CCA>GCA	p.P1083A		NM_005401	NP_005392	Q15678	PTN14_HUMAN	protein tyrosine phosphatase, non-receptor type	1083	Tyrosine-protein phosphatase.				lymphangiogenesis	cytoplasm|cytoskeleton	protein tyrosine phosphatase activity|receptor tyrosine kinase binding			breast(2)|ovary(1)|kidney(1)|skin(1)	5				OV - Ovarian serous cystadenocarcinoma(81;0.00181)|all cancers(67;0.00194)|Epithelial(68;0.0157)|GBM - Glioblastoma multiforme(131;0.155)		ACATCTTCTGGACAGCCGTGA	0.438		NA											37	74					0	0	0	0
USH2A	7399	broad.mit.edu	37	1	215848775	215848775	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr1:215848775C>T	uc001hku.1	-	63	12865	c.12478G>A	c.(12478-12480)GCT>ACT	p.A4160T		NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	4160	Extracellular (Potential).|Fibronectin type-III 27.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		ACAGTAGGAGCCAGCTGAGAG	0.542		NA								HNSCC(13;0.011)			12	46					0	0	0	0
OBSCN	84033	broad.mit.edu	37	1	228509058	228509058	+	Missense_Mutation	SNP	C	C	A			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr1:228509058C>A	uc009xez.1	+	55	14560	c.14516C>A	c.(14515-14517)GCA>GAA	p.A4839E	OBSCN_uc001hsn.2_Missense_Mutation_p.A4839E	NM_001098623	NP_001092093	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and	4839					apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			stomach(8)|large_intestine(7)|breast(5)|ovary(4)|skin(2)|central_nervous_system(1)|pancreas(1)	28		Prostate(94;0.0405)				GGGGCCCCAGCAGCCCCCTCT	0.622		NA											8	25					3.1e-07	3.43e-07	1	0
NET1	10276	broad.mit.edu	37	10	5498902	5498902	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr10:5498902G>A	uc001iia.2	+	12	1874	c.1736G>A	c.(1735-1737)CGA>CAA	p.R579Q	NET1_uc010qar.1_Missense_Mutation_p.R398Q|NET1_uc001iib.2_Missense_Mutation_p.R525Q|NET1_uc010qas.1_Missense_Mutation_p.R398Q	NM_001047160	NP_001040625	Q7Z628	ARHG8_HUMAN	neuroepithelial cell transforming gene 1 isoform	579					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of cell growth|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|nucleus	Rho guanyl-nucleotide exchange factor activity			breast(1)	1						CCCGGCATCCGAAGAGCGAGG	0.493		NA											9	38					0	0	0	0
CACNB2	783	broad.mit.edu	37	10	18439891	18439891	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr10:18439891G>A	uc001ipr.2	+	2	260	c.200G>A	c.(199-201)AGT>AAT	p.S67N	CACNB2_uc009xjz.1_Missense_Mutation_p.S67N|CACNB2_uc001ips.2_Missense_Mutation_p.S67N|CACNB2_uc001ipt.2_Missense_Mutation_p.S67N|CACNB2_uc010qcl.1_RNA|CACNB2_uc001ipu.2_Missense_Mutation_p.S39N|CACNB2_uc001ipv.2_Missense_Mutation_p.S39N|CACNB2_uc009xka.1_Missense_Mutation_p.S39N	NM_201596	NP_963890	Q08289	CACB2_HUMAN	calcium channel, voltage-dependent, beta 2	67					axon guidance|neuromuscular junction development	integral to plasma membrane|sarcolemma|voltage-gated calcium channel complex	protein binding|voltage-gated calcium channel activity			large_intestine(1)|central_nervous_system(1)|skin(1)	3					Magnesium Sulfate(DB00653)|Verapamil(DB00661)	ACCTCAAATAGTTTTGTTCGC	0.313		NA											8	78					0	0	0	0
C10orf71	118461	broad.mit.edu	37	10	50532323	50532323	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr10:50532323C>T	uc010qgp.1	+	3	2072	c.1733C>T	c.(1732-1734)GCT>GTT	p.A578V		NM_199459	NP_955629	Q711Q0	CJ071_HUMAN	hypothetical protein LOC118461 isoform 2	578											0						GACCCTACAGCTGACCCCAGT	0.547		NA											14	8					0	0	0	0
STAMBPL1	57559	broad.mit.edu	37	10	90682924	90682924	+	Splice_Site	SNP	G	G	C			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr10:90682924G>C	uc001kfk.2	+	11	1678	c.1255_splice	c.e11-1	p.I419_splice	STAMBPL1_uc010qmx.1_Intron|STAMBPL1_uc009xto.2_Splice_Site|STAMBPL1_uc001kfl.2_Splice_Site_p.I419_splice|STAMBPL1_uc001kfn.2_Splice_Site_p.I253_splice	NM_020799	NP_065850	Q96FJ0	STALP_HUMAN	STAM binding protein-like 1								metal ion binding|metallopeptidase activity|protein binding			ovary(1)	1		Colorectal(252;0.0381)		Colorectal(12;6.38e-05)|COAD - Colon adenocarcinoma(12;7.75e-05)		TTCTTTCCTAGATATGCAAAC	0.313		NA											6	20					0	0	0	0
PNLIP	5406	broad.mit.edu	37	10	118306919	118306919	+	Missense_Mutation	SNP	C	C	T	rs142749694		TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr10:118306919C>T	uc001lcm.2	+	3	203	c.160C>T	c.(160-162)CGC>TGC	p.R54C		NM_000936	NP_000927	P16233	LIPP_HUMAN	pancreatic lipase precursor	54					lipid catabolic process|retinoid metabolic process|steroid metabolic process	extracellular region	retinyl-palmitate esterase activity|triglyceride lipase activity			ovary(1)|central_nervous_system(1)|skin(1)	3				all cancers(201;0.0131)	Bentiromide(DB00522)|Orlistat(DB01083)	TGTCAACACCCGCTTCCTCCT	0.373		NA											35	16					0	0	0	0
HSPA12A	259217	broad.mit.edu	37	10	118434882	118434882	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr10:118434882G>C	uc001lct.2	-	12	1543	c.1438C>G	c.(1438-1440)CTG>GTG	p.L480V	HSPA12A_uc001lcu.2_Missense_Mutation_p.L397V	NM_025015	NP_079291	O43301	HS12A_HUMAN	heat shock 70kDa protein 12A	480							ATP binding			ovary(1)	1				all cancers(201;0.0158)		CCGCCCACCAGAAAGAGGAAC	0.622		NA											4	12					0	0	0	0
CPXM2	119587	broad.mit.edu	37	10	125526664	125526664	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr10:125526664G>A	uc001lhk.1	-	10	1629	c.1304C>T	c.(1303-1305)TCG>TTG	p.S435L	CPXM2_uc001lhj.2_RNA	NM_198148	NP_937791	Q8N436	CPXM2_HUMAN	carboxypeptidase X (M14 family), member 2	435					cell adhesion|proteolysis	extracellular space	metallocarboxypeptidase activity|zinc ion binding			ovary(2)	2		all_lung(145;0.174)|Colorectal(57;0.178)|Glioma(114;0.222)|all_neural(114;0.226)|Lung NSC(174;0.233)		COAD - Colon adenocarcinoma(40;0.212)|Colorectal(40;0.237)		TCCCAGCTCCGAGCCCTGGAG	0.552		NA											21	22					0	0	0	0
C10orf137	26098	broad.mit.edu	37	10	127429569	127429569	+	Splice_Site	SNP	G	G	C			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr10:127429569G>C	uc001liq.1	+	17	2464	c.2171_splice	c.e17-1	p.D724_splice	C10orf137_uc001lin.2_Splice_Site_p.D690_splice|C10orf137_uc001lio.1_Splice_Site_p.D690_splice|C10orf137_uc001lip.1_Splice_Site_p.D428_splice|C10orf137_uc001lir.2_Splice_Site_p.D218_splice|C10orf137_uc001lis.1_Splice_Site_p.D50_splice	NM_015608	NP_056423	Q3B7T1	EDRF1_HUMAN	erythroid differentiation-related factor 1						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	binding			ovary(5)|large_intestine(3)|lung(2)	10		all_lung(145;0.0096)|Lung NSC(174;0.0145)|Colorectal(57;0.0846)|all_neural(114;0.0936)				TTTCTAAACAGATACTTATTG	0.378		NA											29	100					0	0	0	0
SLC17A6	57084	broad.mit.edu	37	11	22363086	22363086	+	Silent	SNP	G	G	A			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr11:22363086G>A	uc001mqk.2	+	2	512	c.99G>A	c.(97-99)AAG>AAA	p.K33K		NM_020346	NP_065079	Q9P2U8	VGLU2_HUMAN	solute carrier family 17 (sodium-dependent	33	Cytoplasmic (Potential).				sodium ion transport	cell junction|integral to membrane|synaptic vesicle membrane|synaptosome	L-glutamate transmembrane transporter activity|symporter activity			ovary(3)|breast(1)	4						TGCTGGAGAAGAAGCAAGACA	0.642		NA											11	45					0	0	0	0
SLC43A1	8501	broad.mit.edu	37	11	57268800	57268800	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr11:57268800C>T	uc001nkk.2	-	3	275	c.157G>A	c.(157-159)GAG>AAG	p.E53K	SLC43A1_uc001nkl.2_Missense_Mutation_p.E53K	NM_003627	NP_003618	O75387	LAT3_HUMAN	solute carrier family 43, member 1	53					cellular nitrogen compound metabolic process|ion transport	integral to plasma membrane	neutral amino acid transmembrane transporter activity				0						GTGCTGCTCTCAGCTGAGGAG	0.607		NA											5	34					0	0	0	0
VWA5A	4013	broad.mit.edu	37	11	123989062	123989062	+	Missense_Mutation	SNP	A	A	G			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr11:123989062A>G	uc001pzu.2	+	5	622	c.413A>G	c.(412-414)GAT>GGT	p.D138G	VWA5A_uc001pzr.2_Missense_Mutation_p.D138G|VWA5A_uc001pzs.2_Missense_Mutation_p.D138G|VWA5A_uc010sae.1_Missense_Mutation_p.D154G|VWA5A_uc001pzt.2_Missense_Mutation_p.D138G	NM_001130142	NP_001123614	O00534	VMA5A_HUMAN	BCSC-1 isoform 1	138										upper_aerodigestive_tract(1)|ovary(1)	2						CTGGAAGCAGATGGGGCTCTG	0.537		NA											15	89					0	0	0	0
EFCAB4B	84766	broad.mit.edu	37	12	3765560	3765560	+	Missense_Mutation	SNP	A	A	C			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr12:3765560A>C	uc001qmj.2	-	9	1347	c.775T>G	c.(775-777)TTT>GTT	p.F259V	EFCAB4B_uc010sen.1_Missense_Mutation_p.F259V|EFCAB4B_uc010seo.1_Missense_Mutation_p.F259V|EFCAB4B_uc001qmi.1_RNA	NM_032680	NP_116069	Q9BSW2	EFC4B_HUMAN	EF-hand calcium binding domain 4B isoform c	259	Potential.				activation of store-operated calcium channel activity|store-operated calcium entry	cytoplasm	calcium ion binding|protein binding			ovary(1)|pancreas(1)	2			OV - Ovarian serous cystadenocarcinoma(31;0.00287)|COAD - Colon adenocarcinoma(12;0.0264)			CGGGCTTGAAACCTCTCTGTG	0.498		NA											10	54					0	0	0	0
M6PR	4074	broad.mit.edu	37	12	9095069	9095069	+	Silent	SNP	T	T	C			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr12:9095069T>C	uc001qvf.2	-	6	824	c.654A>G	c.(652-654)AAA>AAG	p.K218K		NM_002355	NP_002346	P20645	MPRD_HUMAN	cation-dependent mannose-6-phosphate receptor	218	Cytoplasmic (Potential).				endosome to lysosome transport|receptor-mediated endocytosis	cell surface|endosome|integral to plasma membrane|lysosomal membrane	mannose binding|mannose transmembrane transporter activity|transmembrane receptor activity				0		Hepatocellular(102;0.137)		BRCA - Breast invasive adenocarcinoma(232;0.0146)		GCTCCATTCCTTTGGCTCCCA	0.478		NA											47	269					0	0	0	0
ESPL1	9700	broad.mit.edu	37	12	53663848	53663848	+	Silent	SNP	G	G	A			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr12:53663848G>A	uc001sck.2	+	3	1213	c.1122G>A	c.(1120-1122)CTG>CTA	p.L374L	ESPL1_uc001scj.2_Silent_p.L49L	NM_012291	NP_036423	Q14674	ESPL1_HUMAN	separase	374					apoptosis|cytokinesis|establishment of mitotic spindle localization|mitotic sister chromatid segregation|negative regulation of sister chromatid cohesion|positive regulation of mitotic metaphase/anaphase transition|proteolysis	centrosome|nucleus	cysteine-type peptidase activity|protein binding			lung(1)|kidney(1)|skin(1)	3						GCTCTCTTCTGCAGCAGCTGC	0.537		NA											23	11					0	0	0	0
HOXC4	3221	broad.mit.edu	37	12	54448755	54448755	+	Silent	SNP	C	C	A			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr12:54448755C>A	uc001seu.2	+	4	1241	c.561C>A	c.(559-561)ATC>ATA	p.I187I	HOXC4_uc001sex.2_Silent_p.I187I	NM_014620	NP_055435	P09017	HXC4_HUMAN	homeobox C4	187	Homeobox.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1						GGAGAAGGATCGAGATCGCCC	0.537		NA											13	8					3.46e-05	3.74e-05	1	0
GDF11	10220	broad.mit.edu	37	12	56143303	56143303	+	Silent	SNP	T	T	C			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr12:56143303T>C	uc001shq.2	+	3	898	c.861T>C	c.(859-861)CTT>CTC	p.L287L	GDF11_uc010spv.1_Silent_p.L287L	NM_005811	NP_005802	O95390	GDF11_HUMAN	growth differentiation factor 11 precursor	287					growth|mesoderm development|skeletal system development	extracellular space	cytokine activity|growth factor activity			kidney(1)	1						TCATGGAGCTTCGAGTCCTAG	0.572		NA											3	64					0	0	0	0
HNF1A	6927	broad.mit.edu	37	12	121426777	121426777	+	Silent	SNP	G	G	A			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr12:121426777G>A	uc001tzg.2	+	2	491	c.468G>A	c.(466-468)ACG>ACA	p.T156T	HNF1A_uc001tze.1_Silent_p.T156T|HNF1A_uc001tzf.2_Silent_p.T156T|HNF1A_uc010szn.1_Silent_p.T156T	NM_000545	NP_000536	P20823	HNF1A_HUMAN	hepatic nuclear factor-1-alpha	156	Interaction with DNA.				glucose homeostasis|glucose import|insulin secretion|positive regulation of transcription initiation from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|renal glucose absorption	cytoplasm|nucleus|protein complex	DNA binding|protein dimerization activity|protein heterodimerization activity|protein homodimerization activity|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			liver(92)|large_intestine(15)|endometrium(6)|breast(2)|lung(1)	116	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)					CCATGAAGACGCAGAAGCGGG	0.622		NA							Hepatic_Adenoma_Familial_Clustering_of				10	19					0	0	0	0
BRCA2	675	broad.mit.edu	37	13	32913203	32913203	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr13:32913203G>A	uc001uub.1	+	11	4938	c.4711G>A	c.(4711-4713)GAG>AAG	p.E1571K		NM_000059	NP_000050	P51587	BRCA2_HUMAN	breast cancer 2, early onset	1571					cell cycle cytokinesis|centrosome duplication|double-strand break repair via homologous recombination|negative regulation of mammary gland epithelial cell proliferation|nucleotide-excision repair|positive regulation of transcription, DNA-dependent|regulation of S phase of mitotic cell cycle	BRCA2-MAGE-D1 complex|centrosome|nucleoplasm|stored secretory granule	gamma-tubulin binding|H3 histone acetyltransferase activity|H4 histone acetyltransferase activity|protease binding|single-stranded DNA binding			ovary(20)|endometrium(8)|lung(7)|breast(7)|oesophagus(5)|large_intestine(4)|central_nervous_system(3)|pancreas(3)|skin(2)|upper_aerodigestive_tract(1)|cervix(1)|salivary_gland(1)|liver(1)|kidney(1)	64		Lung SC(185;0.0262)		all cancers(112;7.13e-07)|Epithelial(112;1.59e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.000732)|BRCA - Breast invasive adenocarcinoma(63;0.0291)|GBM - Glioblastoma multiforme(144;0.0704)		AAAGTACAGAGAGGCCTGTAA	0.383		NA	D|Mis|N|F|S		breast|ovarian|pancreatic	breast|ovarian|pancreatic|leukemia  (FANCB|FANCD1)		Direct_reversal_of_damage|Homologous_recombination	Fanconi_Anemia_type_D1_bi-allelic_BRCA2_mutations|Fanconi_Anemia|Pancreatic_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_BRCA2_type|Hereditary_Prostate_Cancer|Li-Fraumeni_syndrome	TCGA Ovarian(8;0.087)			45	31					0	0	0	0
DNAJC15	29103	broad.mit.edu	37	13	43643083	43643083	+	Missense_Mutation	SNP	A	A	T			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr13:43643083A>T	uc001uyy.2	+	3	579	c.178A>T	c.(178-180)ATC>TTC	p.I60F		NM_013238	NP_037370	Q9Y5T4	DJC15_HUMAN	DNAJ domain-containing	60						integral to membrane	heat shock protein binding				0		Lung NSC(96;4.3e-06)|Breast(139;0.00869)|Prostate(109;0.0181)|Lung SC(185;0.0262)|Hepatocellular(98;0.114)		GBM - Glioblastoma multiforme(144;0.000732)|BRCA - Breast invasive adenocarcinoma(63;0.0737)		CGCATTTCGGATCTGGAAACC	0.333		NA											7	12					0	0	0	0
LRRC16B	90668	broad.mit.edu	37	14	24532038	24532038	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr14:24532038G>A	uc001wlj.2	+	29	2846	c.2689G>A	c.(2689-2691)GAA>AAA	p.E897K	LRRC16B_uc001wlk.2_5'UTR	NM_138360	NP_612369	Q8ND23	LR16B_HUMAN	leucine rich repeat containing 16B	897										ovary(2)|breast(2)|pancreas(1)	5				GBM - Glioblastoma multiforme(265;0.019)		CACAGATGATGAACTTGGGAC	0.597		NA											8	85					0	0	0	0
ADCY4	196883	broad.mit.edu	37	14	24789048	24789048	+	Nonsense_Mutation	SNP	G	G	C			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr14:24789048G>C	uc001wov.2	-	21	2639	c.2633C>G	c.(2632-2634)TCA>TGA	p.S878*	ADCY4_uc001wow.2_Nonsense_Mutation_p.S878*|ADCY4_uc010toh.1_Nonsense_Mutation_p.S564*|ADCY4_uc001wox.2_Nonsense_Mutation_p.S878*|ADCY4_uc001woy.2_Nonsense_Mutation_p.S878*	NM_139247	NP_640340	Q8NFM4	ADCY4_HUMAN	adenylate cyclase 4	878	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	cytoplasm|integral to membrane|plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding|protein binding			ovary(1)|lung(1)|pancreas(1)	3				GBM - Glioblastoma multiforme(265;0.0192)		GTCTGGGACTGAGGCGAAGAG	0.493		NA											6	76					0	0	0	0
C14orf106	55320	broad.mit.edu	37	14	45679696	45679696	+	Missense_Mutation	SNP	A	A	T			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr14:45679696A>T	uc001wwf.2	-	14	3498	c.3039T>A	c.(3037-3039)GAT>GAA	p.D1013E		NM_018353	NP_060823	Q6P0N0	M18BP_HUMAN	chromosome 14 open reading frame 106	1013	Poly-Asp.				cell division|CenH3-containing nucleosome assembly at centromere|mitosis	chromosome, centromeric region|nucleoplasm	DNA binding				0						TTGGCAGAATATCATCATCAT	0.373		NA											14	97					0	0	0	0
SIPA1L1	26037	broad.mit.edu	37	14	72169178	72169178	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr14:72169178C>T	uc001xms.2	+	12	3950	c.3602C>T	c.(3601-3603)ACG>ATG	p.T1201M	SIPA1L1_uc001xmt.2_Missense_Mutation_p.T1201M|SIPA1L1_uc001xmu.2_Missense_Mutation_p.T1201M|SIPA1L1_uc001xmv.2_Missense_Mutation_p.T1201M|SIPA1L1_uc010ttm.1_Missense_Mutation_p.T676M|SIPA1L1_uc001xmw.2_Translation_Start_Site	NM_015556	NP_056371	O43166	SI1L1_HUMAN	signal-induced proliferation-associated 1 like	1201					actin cytoskeleton reorganization|activation of Rap GTPase activity|regulation of dendritic spine morphogenesis	cell junction|cytoplasm|dendritic spine|postsynaptic density|postsynaptic membrane|synaptosome	GTPase activator activity			ovary(3)|breast(1)	4				all cancers(60;0.00169)|BRCA - Breast invasive adenocarcinoma(234;0.00912)|OV - Ovarian serous cystadenocarcinoma(108;0.0109)		GGAAAATCCACGCCTAGCTGG	0.478		NA											8	27					0	0	0	0
GABRB3	2562	broad.mit.edu	37	15	26806279	26806279	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr15:26806279G>A	uc001zaz.2	-	8	1022	c.880C>T	c.(880-882)CGG>TGG	p.R294W	GABRB3_uc010uae.1_Missense_Mutation_p.R209W|GABRB3_uc001zba.2_Missense_Mutation_p.R294W|GABRB3_uc001zbb.2_Missense_Mutation_p.R350W	NM_000814	NP_000805	P28472	GBRB3_HUMAN	gamma-aminobutyric acid (GABA) A receptor, beta	294					synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			upper_aerodigestive_tract(1)|ovary(1)|lung(1)|liver(1)|central_nervous_system(1)	5		all_cancers(20;1.89e-22)|all_lung(180;6.35e-15)|Breast(32;0.000279)|Colorectal(260;0.232)		all cancers(64;1.46e-07)|Epithelial(43;2.89e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0251)|COAD - Colon adenocarcinoma(236;0.235)|Lung(196;0.243)	Ethchlorvynol(DB00189)|Flurazepam(DB00690)|Lorazepam(DB00186)|Midazolam(DB00683)	AAGGTCTCCCGAAGGTGGGTG	0.473		NA											12	47					0	0	0	0
FSIP1	161835	broad.mit.edu	37	15	40057834	40057834	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr15:40057834G>C	uc001zki.2	-	4	642	c.424C>G	c.(424-426)CAA>GAA	p.Q142E		NM_152597	NP_689810	Q8NA03	FSIP1_HUMAN	fibrous sheath interacting protein 1	142	Potential.									ovary(2)|skin(1)	3		all_cancers(109;2.66e-19)|all_epithelial(112;2.66e-16)|Lung NSC(122;1.5e-11)|all_lung(180;4.03e-10)|Melanoma(134;0.0575)|Ovarian(310;0.0827)|Colorectal(260;0.119)		GBM - Glioblastoma multiforme(113;8.22e-06)|BRCA - Breast invasive adenocarcinoma(123;0.142)		TCTAGACCTTGCTTCTTAATT	0.284		NA											8	25					0	0	0	0
BAHD1	22893	broad.mit.edu	37	15	40750963	40750963	+	Silent	SNP	C	C	G			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr15:40750963C>G	uc001zlu.2	+	2	371	c.300C>G	c.(298-300)CCC>CCG	p.P100P	BAHD1_uc001zlt.2_Silent_p.P100P|BAHD1_uc010bbp.1_Silent_p.P100P|BAHD1_uc001zlv.2_Silent_p.P100P	NM_014952	NP_055767	Q8TBE0	BAHD1_HUMAN	bromo adjacent homology domain containing 1	100					heterochromatin formation|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromatin silencing complex|chromosome	chromatin binding|DNA binding|protein binding				0		all_cancers(109;8.28e-19)|all_epithelial(112;2.64e-15)|Lung NSC(122;5.14e-11)|all_lung(180;1.27e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;3.46e-06)|BRCA - Breast invasive adenocarcinoma(123;0.08)		CCAAGCCCCCCAGCCCGGCCC	0.657		NA											4	41					0	0	0	0
C16orf11	146325	broad.mit.edu	37	16	615181	615181	+	Silent	SNP	C	C	G			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr16:615181C>G	uc002chk.2	+	3	1869	c.1590C>G	c.(1588-1590)CTC>CTG	p.L530L	NHLRC4_uc002chl.2_5'Flank|PIGQ_uc010bqw.2_5'Flank	NM_145270	NP_660313	P0CG20	CP011_HUMAN	hypothetical protein LOC146325	530										central_nervous_system(1)	1						CCCCAGGGCTCCCCCTCGCAG	0.692		NA											11	16					0	0	0	0
MSLNL	401827	broad.mit.edu	37	16	825511	825511	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr16:825511G>C	uc002cjz.1	-	5	1250	c.1250C>G	c.(1249-1251)TCT>TGT	p.S417C		NM_001025190	NP_001020361	Q96KJ4	MSLNL_HUMAN	mesothelin-like	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					cell adhesion	integral to membrane				breast(3)|ovary(1)	4						GAGCTGGGCAGAACGGCGCTC	0.682		NA											6	14					0	0	0	0
ZNF598	90850	broad.mit.edu	37	16	2053657	2053657	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr16:2053657C>T	uc002cof.1	-	4	310	c.295G>A	c.(295-297)GAT>AAT	p.D99N	ZNF598_uc002coe.1_5'Flank	NM_178167	NP_835461	Q86UK7	ZN598_HUMAN	zinc finger protein 598	99						intracellular	zinc ion binding			lung(1)|breast(1)	2						AAGTAGATATCATATTTCTTC	0.547		NA									OREG0023548	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	12	42					0	0	0	0
PPL	5493	broad.mit.edu	37	16	4934903	4934903	+	Silent	SNP	G	G	C			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr16:4934903G>C	uc002cyd.1	-	22	3843	c.3753C>G	c.(3751-3753)CTC>CTG	p.L1251L		NM_002705	NP_002696	O60437	PEPL_HUMAN	periplakin	1251	Potential.				keratinization	cytoskeleton|desmosome|mitochondrion|nucleus	protein binding|structural constituent of cytoskeleton			ovary(4)|central_nervous_system(1)|skin(1)	6						TCTCCTCCCTGAGCCGCTGAA	0.522		NA											14	59					0	0	0	0
ACSM3	6296	broad.mit.edu	37	16	20781560	20781560	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr16:20781560G>A	uc002dhr.2	+	2	391	c.204G>A	c.(202-204)TGG>TGA	p.W68*	ACSM3_uc002dhq.2_Nonsense_Mutation_p.W68*|ACSM3_uc010vba.1_Nonsense_Mutation_p.W60*	NM_005622	NP_005613	Q53FZ2	ACSM3_HUMAN	SA hypertension-associated homolog isoform 1	68					regulation of blood pressure	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|metal ion binding			ovary(1)	1						TGGACCAATGGACTGATAAGG	0.328		NA											4	30					0	0	0	0
CD2BP2	10421	broad.mit.edu	37	16	30364880	30364880	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr16:30364880G>A	uc002dxr.2	-	4	870	c.617C>T	c.(616-618)GCC>GTC	p.A206V	CD2BP2_uc002dxs.2_Missense_Mutation_p.A206V	NM_006110	NP_006101	O95400	CD2B2_HUMAN	CD2 antigen (cytoplasmic tail) binding protein	206					assembly of spliceosomal tri-snRNP	cytoplasm|nucleoplasm|U5 snRNP	protein binding|ribonucleoprotein binding			ovary(1)	1						CATCTGGTCGGCCAACCCGGA	0.657		NA											3	22					0	0	0	0
ZNF689	115509	broad.mit.edu	37	16	30621254	30621254	+	Missense_Mutation	SNP	A	A	G			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr16:30621254A>G	uc002dyx.2	-	1	429	c.109T>C	c.(109-111)TAC>CAC	p.Y37H	ZNF689_uc010bzy.2_Intron	NM_138447	NP_612456	Q96CS4	ZN689_HUMAN	zinc finger protein HIT-39	37	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0			Colorectal(24;0.198)			GGGGAGAAGTACACGGCCACG	0.692		NA											2	11					0	0	0	0
KLHDC4	54758	broad.mit.edu	37	16	87744911	87744911	+	Missense_Mutation	SNP	G	G	A	rs113844965		TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr16:87744911G>A	uc002fki.2	-	9	1020	c.974C>T	c.(973-975)TCG>TTG	p.S325L	KLHDC4_uc002fkh.1_5'Flank|KLHDC4_uc010cht.1_Missense_Mutation_p.S144L|KLHDC4_uc002fkj.2_Missense_Mutation_p.S294L|KLHDC4_uc002fkk.2_Missense_Mutation_p.S144L|KLHDC4_uc002fkl.2_Missense_Mutation_p.S268L|KLHDC4_uc010chu.1_Missense_Mutation_p.S144L	NM_017566	NP_060036	Q8TBB5	KLDC4_HUMAN	kelch domain containing 4	325	Kelch 5.									pancreas(2)	2				BRCA - Breast invasive adenocarcinoma(80;0.0283)		GAACTCGCCCGACAGGCTCTC	0.582		NA											9	33					0	0	0	0
OR1E1	8387	broad.mit.edu	37	17	3301357	3301357	+	Silent	SNP	C	C	T			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr17:3301357C>T	uc002fvj.1	-	1	348	c.348G>A	c.(346-348)GTG>GTA	p.V116V		NM_003553	NP_003544	P30953	OR1E1_HUMAN	olfactory receptor, family 1, subfamily E,	116	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						AGGCCATGGCCACAAGGAGGA	0.577		NA											13	26					0	0	0	0
GSG2	83903	broad.mit.edu	37	17	3629572	3629572	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr17:3629572G>A	uc002fwp.2	+	1	2376	c.2343G>A	c.(2341-2343)ATG>ATA	p.M781I	ITGAE_uc002fwo.3_Intron|ITGAE_uc002fwn.3_5'Flank	NM_031965	NP_114171	Q8TF76	HASP_HUMAN	haspin	781	Protein kinase.				cell cycle|chromatin modification|intracellular protein kinase cascade	nucleus	ATP binding|protein serine/threonine kinase activity				0						ACAGGACAATGCTGAACTTCA	0.433		NA											11	34					0	0	0	0
ZZEF1	23140	broad.mit.edu	37	17	3961378	3961378	+	Missense_Mutation	SNP	T	T	C			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr17:3961378T>C	uc002fxe.2	-	32	5139	c.5075A>G	c.(5074-5076)AAT>AGT	p.N1692S	ZZEF1_uc002fxh.2_Missense_Mutation_p.N6S|ZZEF1_uc002fxi.2_5'UTR|ZZEF1_uc002fxj.1_Missense_Mutation_p.N305S	NM_015113	NP_055928	O43149	ZZEF1_HUMAN	zinc finger, ZZ type with EF hand domain 1	1692							calcium ion binding|zinc ion binding			ovary(2)|central_nervous_system(1)|pancreas(1)	4						GGCGAGATCATTGGGTTCCCA	0.458		NA											10	23					0	0	0	0
NLRP1	22861	broad.mit.edu	37	17	5486123	5486123	+	Silent	SNP	C	C	T			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr17:5486123C>T	uc002gci.2	-	2	870	c.315G>A	c.(313-315)CTG>CTA	p.L105L	NLRP1_uc002gcg.1_Silent_p.L105L|NLRP1_uc002gck.2_Silent_p.L105L|NLRP1_uc002gcj.2_Silent_p.L105L|NLRP1_uc002gcl.2_Silent_p.L105L|NLRP1_uc002gch.3_Silent_p.L105L|NLRP1_uc010clh.2_Silent_p.L105L	NM_033004	NP_127497	Q9C000	NALP1_HUMAN	NLR family, pyrin domain containing 1 isoform 1	105					defense response to bacterium|induction of apoptosis|neuron apoptosis|positive regulation of interleukin-1 beta secretion|response to muramyl dipeptide	cytoplasm|NALP1 inflammasome complex|nucleus	ATP binding|caspase activator activity|enzyme binding|protein domain specific binding			lung(4)|breast(2)|ovary(1)|central_nervous_system(1)|skin(1)	9		Colorectal(1115;3.48e-05)				TGGGAGACCCCAGGTGGGGTT	0.602		NA											3	32					0	0	0	0
TP53	7157	broad.mit.edu	37	17	7577094	7577094	+	Missense_Mutation	SNP	G	G	A	rs28934574		TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr17:7577094G>A	uc002gim.2	-	8	1038	c.844C>T	c.(844-846)CGG>TGG	p.R282W	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Missense_Mutation_p.R282W|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.R150W|TP53_uc010cng.1_Missense_Mutation_p.R150W|TP53_uc002gii.1_Missense_Mutation_p.R150W|TP53_uc010cnh.1_Missense_Mutation_p.R282W|TP53_uc010cni.1_Missense_Mutation_p.R282W|TP53_uc002gij.2_Missense_Mutation_p.R282W	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	282	|Interaction with E4F1.|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		R -> G (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> L (in sporadic cancers; somatic mutation).|R -> P (in sporadic cancers; somatic mutation).|DR -> EW (in sporadic cancers; somatic mutation).|R -> Q (in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> H (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R282W(367)|p.R282G(27)|p.R282Q(20)|p.R282P(14)|p.R282R(8)|p.0?(7)|p.R282L(3)|p.D281fs*63(2)|p.?(2)|p.R282fs*24(2)|p.D281_R282>EW(2)|p.A276_R283delACPGRDRR(1)|p.R280fs*62(1)|p.R282_E287delRRTEEE(1)|p.G279fs*59(1)|p.S269fs*21(1)|p.C275_R283delCACPGRDRR(1)|p.D281_R282insXX(1)|p.L265_K305del41(1)|p.R282H(1)|p.R283_T284>T(1)|p.V272_K292del21(1)|p.R282fs*63(1)|p.C275fs*20(1)|p.D281_R282delDR(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		TCTGTGCGCCGGTCTCTCCCA	0.557		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			16	32					0	0	0	0
DNAH2	146754	broad.mit.edu	37	17	7667311	7667311	+	Silent	SNP	C	C	G			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr17:7667311C>G	uc002giu.1	+	18	3155	c.3141C>G	c.(3139-3141)CTC>CTG	p.L1047L		NM_020877	NP_065928	Q9P225	DYH2_HUMAN	dynein heavy chain domain 3	1047	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(6)|skin(6)|central_nervous_system(1)	13		all_cancers(10;4.66e-07)|Prostate(122;0.081)				CTGGGCGCCTCCTGGAGCTGC	0.622		NA											7	49					0	0	0	0
MYH3	4621	broad.mit.edu	37	17	10545560	10545560	+	Silent	SNP	G	G	A			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr17:10545560G>A	uc002gmq.1	-	16	2033	c.1956C>T	c.(1954-1956)TTC>TTT	p.F652F		NM_002470	NP_002461	P11055	MYH3_HUMAN	myosin, heavy chain 3, skeletal muscle,	652	Myosin head-like.				muscle filament sliding|muscle organ development	cytosol|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(4)|central_nervous_system(2)|pancreas(1)	7						TTCTTACCCTGAAAAGGGCAG	0.388		NA											8	32					0	0	0	0
NBR1	4077	broad.mit.edu	37	17	41347008	41347008	+	Missense_Mutation	SNP	A	A	G			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr17:41347008A>G	uc010czd.2	+	14	1842	c.1702A>G	c.(1702-1704)ATA>GTA	p.I568V	NBR1_uc010diz.2_Missense_Mutation_p.I568V|NBR1_uc010whu.1_Missense_Mutation_p.I568V|NBR1_uc010whv.1_Missense_Mutation_p.I568V|NBR1_uc010whw.1_Missense_Mutation_p.I547V|NBR1_uc010whx.1_3'UTR	NM_031862	NP_114068	Q14596	NBR1_HUMAN	neighbor of BRCA1 gene 1	568	ATG8 family protein-binding.				macroautophagy|protein oligomerization	autophagic vacuole|cytoplasmic vesicle|cytosol|late endosome|lysosome|sarcomere	ubiquitin binding|zinc ion binding			skin(1)	1		Breast(137;0.00086)		BRCA - Breast invasive adenocarcinoma(366;0.0934)		GCTGTTGGATATAAACATTGT	0.438		NA											8	26					0	0	0	0
MPP3	4356	broad.mit.edu	37	17	41888554	41888554	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr17:41888554C>G	uc002iei.3	-	17	1441	c.1275G>C	c.(1273-1275)AAG>AAC	p.K425N	MPP3_uc002ieh.2_Missense_Mutation_p.K450N|MPP3_uc002iej.2_RNA	NM_001932	NP_001923	Q13368	MPP3_HUMAN	palmitoylated membrane protein 3	425	Guanylate kinase-like.				signal transduction	cell surface|integral to plasma membrane	guanylate kinase activity			large_intestine(1)|skin(1)	2		Breast(137;0.00394)		BRCA - Breast invasive adenocarcinoma(366;0.119)		TCTCATGGCTCTTTCGGGGCC	0.488		NA											12	47					0	0	0	0
ITGA3	3675	broad.mit.edu	37	17	48145541	48145541	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr17:48145541C>G	uc010dbl.2	+	4	1000	c.536C>G	c.(535-537)ACC>AGC	p.T179S	ITGA3_uc010dbm.2_Missense_Mutation_p.T179S	NM_002204	NP_002195	P26006	ITA3_HUMAN	integrin alpha 3 isoform a precursor	179	Extracellular (Potential).				blood coagulation|cell-matrix adhesion|integrin-mediated signaling pathway|leukocyte migration	cell surface|integrin complex	protein binding|receptor activity			ovary(2)|pancreas(1)	3						GACTGGCAGACCTACCACAAC	0.582		NA											8	85					0	0	0	0
USH1G	124590	broad.mit.edu	37	17	72915717	72915717	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr17:72915717G>A	uc002jme.1	-	2	1397	c.1214C>T	c.(1213-1215)GCC>GTC	p.A405V	USH1G_uc010wro.1_Missense_Mutation_p.A302V	NM_173477	NP_775748	Q495M9	USH1G_HUMAN	Usher syndrome 1G protein	405	SAM.				equilibrioception|photoreceptor cell maintenance|sensory perception of sound	actin cytoskeleton				skin(2)	2	all_lung(278;0.172)|Lung NSC(278;0.207)					CAGGAGGGCGGCAAAGTCCTC	0.627		NA											4	60					0	0	0	0
TNRC6C	57690	broad.mit.edu	37	17	76045225	76045225	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr17:76045225G>A	uc002jud.2	+	4	682	c.82G>A	c.(82-84)GTC>ATC	p.V28I	TNRC6C_uc002juf.2_Missense_Mutation_p.V28I|TNRC6C_uc002jue.2_Missense_Mutation_p.V28I	NM_018996	NP_061869	Q9HCJ0	TNR6C_HUMAN	trinucleotide repeat containing 6C isoform 2	28	Sufficient for interaction with argonaute family proteins.				gene silencing by RNA|regulation of translation		nucleotide binding|RNA binding			ovary(1)|central_nervous_system(1)	2			BRCA - Breast invasive adenocarcinoma(99;0.00269)|Lung(188;0.0973)			TGGCGCACTCGTCCAAAGCCC	0.557		NA											11	59					0	0	0	0
FAM59A	64762	broad.mit.edu	37	18	29847915	29847915	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr18:29847915G>C	uc002kxl.2	-	6	2606	c.2550C>G	c.(2548-2550)ATC>ATG	p.I850M	FAM59A_uc002kxk.1_Missense_Mutation_p.I849M	NM_022751	NP_073588	Q9H706	FA59A_HUMAN	family with sequence similarity 59, member A	850	SAM.									ovary(1)|skin(1)	2						CCTCTGAGAGGATTTCTTCCG	0.418		NA											6	34					0	0	0	0
ALPK2	115701	broad.mit.edu	37	18	56184167	56184167	+	Silent	SNP	G	G	T	rs61732436		TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr18:56184167G>T	uc002lhj.3	-	9	6127	c.5913C>A	c.(5911-5913)ATC>ATA	p.I1971I		NM_052947	NP_443179	Q86TB3	ALPK2_HUMAN	heart alpha-kinase	1971	Alpha-type protein kinase.						ATP binding|protein serine/threonine kinase activity			ovary(7)|skin(5)|lung(1)|central_nervous_system(1)	14						AGTTCCTTTGGATGAGCTCAT	0.502		NA											18	73					2.38e-13	2.76e-13	1	0
MC4R	4160	broad.mit.edu	37	18	58038766	58038766	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr18:58038766G>A	uc002lie.1	-	1	1236	c.817C>T	c.(817-819)CAG>TAG	p.Q273*		NM_005912	NP_005903	P32245	MC4R_HUMAN	melanocortin 4 receptor	273	Extracellular (Potential).				feeding behavior|G-protein signaling, coupled to cAMP nucleotide second messenger|positive regulation of bone resorption|positive regulation of cAMP biosynthetic process	integral to membrane|plasma membrane	melanocyte-stimulating hormone receptor activity|neuropeptide binding|ubiquitin protein ligase binding			lung(1)	1		Colorectal(73;0.0946)				TATGGATTCTGAGGACAAGAG	0.423		NA											13	51					0	0	0	0
C19orf36	113177	broad.mit.edu	37	19	2096977	2096977	+	Silent	SNP	G	G	T			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr19:2096977G>T	uc002luw.1	+	1	110	c.33G>T	c.(31-33)ACG>ACT	p.T11T	C19orf36_uc002lux.1_Silent_p.T11T|C19orf36_uc010xgw.1_Silent_p.T11T|MOBKL2A_uc002luv.2_5'Flank	NM_001039846	NP_001034935	Q1ZYL8	IZUM4_HUMAN	hypothetical protein LOC113177 isoform 3	11						extracellular region					0		Ovarian(11;1.78e-06)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TGTGCCTGACGGCGGCGCTGG	0.672		NA									OREG0025135	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	10	61					0.000978159	0.00102849	1	0
CREB3L3	84699	broad.mit.edu	37	19	4171169	4171169	+	Silent	SNP	C	C	T			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr19:4171169C>T	uc002lzl.2	+	8	1088	c.972C>T	c.(970-972)GTC>GTT	p.V324V	CREB3L3_uc002lzm.2_Silent_p.V314V|CREB3L3_uc010xib.1_Silent_p.V313V|CREB3L3_uc010xic.1_Missense_Mutation_p.R280C	NM_032607	NP_115996	Q68CJ9	CR3L3_HUMAN	cAMP responsive element binding protein 3-like	324	Helical; Signal-anchor for type II membrane protein; (Potential).				response to unfolded protein	endoplasmic reticulum membrane|integral to membrane|nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|skin(1)	2				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0232)|STAD - Stomach adenocarcinoma(1328;0.18)		GCACCTGTGTCGCAGTGAGTC	0.602		NA											21	23					0	0	0	0
FDX1L	112812	broad.mit.edu	37	19	10426650	10426650	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr19:10426650C>T	uc002mny.1	-	1	42	c.23G>A	c.(22-24)GGA>GAA	p.G8E	FDX1L_uc002mnx.1_RNA	NM_001031734	NP_001026904	Q6P4F2	ADXL_HUMAN	ferredoxin 1-like precursor	8					electron transport chain|transport	mitochondrial matrix	2 iron, 2 sulfur cluster binding|electron carrier activity|metal ion binding			skin(1)	1			OV - Ovarian serous cystadenocarcinoma(20;9.5e-10)|Epithelial(33;2.11e-06)|all cancers(31;5.06e-06)			ACTCACGCCTCCCCGGGCCAT	0.662		NA											3	13					0	0	0	0
LDLR	3949	broad.mit.edu	37	19	11224240	11224240	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr19:11224240C>G	uc002mqk.3	+	10	1556	c.1388C>G	c.(1387-1389)TCT>TGT	p.S463C	LDLR_uc010xlk.1_Missense_Mutation_p.S463C|LDLR_uc010xll.1_Missense_Mutation_p.S422C|LDLR_uc010xlm.1_Missense_Mutation_p.S316C|LDLR_uc010xln.1_Missense_Mutation_p.S336C|LDLR_uc010xlo.1_Missense_Mutation_p.S295C	NM_000527	NP_000518	P01130	LDLR_HUMAN	low density lipoprotein receptor precursor	463	LDL-receptor class B 2.|Extracellular (Potential).				cholesterol homeostasis|cholesterol metabolic process|interspecies interaction between organisms|intestinal cholesterol absorption|low-density lipoprotein particle clearance|receptor-mediated endocytosis	clathrin-coated endocytic vesicle membrane|coated pit|early endosome|endosome membrane|external side of plasma membrane|integral to plasma membrane|low-density lipoprotein particle|lysosome	calcium ion binding|low-density lipoprotein receptor activity|protein binding|very-low-density lipoprotein particle receptor activity			ovary(2)|skin(2)	4		Lung NSC(9;0.000245)|Renal(1328;0.0007)|Hepatocellular(1079;0.0524)		GBM - Glioblastoma multiforme(1328;1.36e-05)|STAD - Stomach adenocarcinoma(1328;0.000766)|Lung(535;0.197)	Methyl aminolevulinate(DB00992)|Porfimer(DB00707)	CACGGCGTCTCTTCCTATGAC	0.632		NA											10	27					0	0	0	0
ZNF208	7757	broad.mit.edu	37	19	22157311	22157311	+	Missense_Mutation	SNP	A	A	C			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr19:22157311A>C	uc002nqp.2	-	4	674	c.525T>G	c.(523-525)TGT>TGG	p.C175W	ZNF208_uc002nqo.1_Intron|ZNF208_uc010ecw.1_5'Flank	NM_007153	NP_009084			zinc finger protein 208											ovary(5)|skin(2)	7		all_lung(12;0.0961)|Lung NSC(12;0.103)				CGTATTCTTTACATTGCAAAT	0.328		NA											8	41					0	0	0	0
ZNF675	171392	broad.mit.edu	37	19	23836955	23836955	+	Silent	SNP	T	T	C			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr19:23836955T>C	uc002nri.2	-	4	962	c.780A>G	c.(778-780)GAA>GAG	p.E260E		NM_138330	NP_612203	Q8TD23	ZN675_HUMAN	zinc finger protein 675	260	C2H2-type 5.				bone resorption|cytokine-mediated signaling pathway|hemopoiesis|I-kappaB kinase/NF-kappaB cascade|negative regulation of JNK cascade|negative regulation of osteoclast differentiation|negative regulation of protein kinase activity|negative regulation of transcription, DNA-dependent|regulation of ossification|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|protein binding|zinc ion binding			ovary(1)|kidney(1)	2		all_lung(12;0.11)|Lung NSC(12;0.163)|all_epithelial(12;0.206)				CTTTGCCACATTCTTCACATT	0.353		NA											10	31					0	0	0	0
FCGBP	8857	broad.mit.edu	37	19	40376315	40376315	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr19:40376315C>G	uc002omp.3	-	25	11997	c.11989G>C	c.(11989-11991)GAG>CAG	p.E3997Q		NM_003890	NP_003881	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein precursor	3997	Cys-rich.					extracellular region	protein binding			ovary(4)|skin(4)|central_nervous_system(1)	9	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			GTTCCTACCTCATAGTAGACA	0.532		NA											6	28					0	0	0	0
BCAM	4059	broad.mit.edu	37	19	45316587	45316587	+	Silent	SNP	C	C	G			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr19:45316587C>G	uc002ozu.2	+	5	629	c.585C>G	c.(583-585)CCC>CCG	p.P195P	BCAM_uc002ozt.1_Silent_p.P195P	NM_005581	NP_005572	P50895	BCAM_HUMAN	basal cell adhesion molecule isoform 1	195	Extracellular (Potential).|Ig-like V-type 2.				cell-matrix adhesion	integral to plasma membrane	laminin binding|laminin receptor activity			skin(1)	1	Lung NSC(12;0.000789)|all_lung(12;0.00218)	Ovarian(192;0.0728)|all_neural(266;0.112)				TGGAGGTGCCCGTAGAGATGA	0.687		NA											18	41					0	0	0	0
IZUMO1	284359	broad.mit.edu	37	19	49245052	49245052	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr19:49245052C>T	uc002pkj.2	-	8	1296	c.748G>A	c.(748-750)GTC>ATC	p.V250I	RASIP1_uc002pki.2_5'Flank|IZUMO1_uc010eme.2_RNA|IZUMO1_uc010emf.2_RNA	NM_182575	NP_872381	Q8IYV9	IZUM1_HUMAN	izumo sperm-egg fusion 1 precursor	250	Ig-like C2-type.|Extracellular (Potential).				fusion of sperm to egg plasma membrane	integral to membrane				ovary(1)	1		all_lung(116;0.000156)|Lung NSC(112;0.000251)|all_epithelial(76;0.000761)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000134)|all cancers(93;0.000348)|Epithelial(262;0.019)|GBM - Glioblastoma multiforme(486;0.022)		TGACCTGTGACGTGAAAATTG	0.632		NA											9	27					0	0	0	0
IL4I1	259307	broad.mit.edu	37	19	50399101	50399101	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr19:50399101C>T	uc002pqt.1	-	3	301	c.223G>A	c.(223-225)GCC>ACC	p.A75T	IL4I1_uc002pqv.1_Missense_Mutation_p.A84T|IL4I1_uc010eno.1_Missense_Mutation_p.A83T|IL4I1_uc002pqw.1_Missense_Mutation_p.A83T|IL4I1_uc002pqu.1_Missense_Mutation_p.A97T	NM_152899	NP_690863	Q96RQ9	OXLA_HUMAN	interleukin 4 induced 1 isoform 1 precursor	75						lysosome	L-amino-acid oxidase activity			lung(1)|ovary(1)|prostate(1)	3		all_lung(116;1.47e-05)|all_neural(266;0.0459)|Ovarian(192;0.0481)		GBM - Glioblastoma multiforme(134;0.00245)|OV - Ovarian serous cystadenocarcinoma(262;0.0169)		AGCACCTTGGCGGCCACCAGC	0.637		NA											12	116					0	0	0	0
ZNF616	90317	broad.mit.edu	37	19	52619847	52619847	+	Silent	SNP	A	A	G			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr19:52619847A>G	uc002pym.2	-	4	853	c.570T>C	c.(568-570)TGT>TGC	p.C190C	ZNF616_uc002pyn.2_RNA	NM_178523	NP_848618	Q08AN1	ZN616_HUMAN	zinc finger protein 616	190	C2H2-type 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				GBM - Glioblastoma multiforme(134;0.00392)|OV - Ovarian serous cystadenocarcinoma(262;0.0189)		AGGCTTTGCCACATTCATTAC	0.373		NA											41	83					0	0	0	0
ADAM17	6868	broad.mit.edu	37	2	9666273	9666273	+	Silent	SNP	G	G	A			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr2:9666273G>A	uc002qzu.2	-	6	903	c.720C>T	c.(718-720)GGC>GGT	p.G240G	ADAM17_uc010ewy.2_Silent_p.G240G|ADAM17_uc010ewz.2_Intron|ADAM17_uc010exa.2_5'Flank	NM_003183	NP_003174	P78536	ADA17_HUMAN	a disintegrin and metalloprotease domain 17	240	Peptidase M12B.|Extracellular (Potential).				B cell differentiation|cell adhesion mediated by integrin|epidermal growth factor receptor signaling pathway|epidermal growth factor receptor transactivation by G-protein coupled receptor signaling pathway|germinal center formation|membrane protein intracellular domain proteolysis|negative regulation of interleukin-8 production|nerve growth factor receptor signaling pathway|Notch signaling pathway|PMA-inducible membrane protein ectodomain proteolysis|positive regulation of cell growth|positive regulation of cell proliferation|positive regulation of chemokine production|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of protein phosphorylation|positive regulation of T cell chemotaxis|positive regulation of transforming growth factor beta receptor signaling pathway|regulation of mast cell apoptosis|response to drug|response to high density lipoprotein particle stimulus|response to hypoxia|response to lipopolysaccharide|spleen development|T cell differentiation in thymus|wound healing, spreading of epidermal cells	actin cytoskeleton|apical plasma membrane|cell surface|cytoplasm|integral to plasma membrane|membrane raft	integrin binding|interleukin-6 receptor binding|metalloendopeptidase activity|PDZ domain binding|SH3 domain binding|zinc ion binding			lung(1)|kidney(1)	2	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.225)		CTTCCCCTCTGCCCATGTATC	0.383		NA											66	111					0	0	0	0
GTF3C2	2976	broad.mit.edu	37	2	27566417	27566417	+	Missense_Mutation	SNP	T	T	A			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr2:27566417T>A	uc002rjv.1	-	3	368	c.5A>T	c.(4-6)GAT>GTT	p.D2V	GTF3C2_uc002rju.1_Missense_Mutation_p.D13V|GTF3C2_uc002rjw.1_Missense_Mutation_p.D2V|GTF3C2_uc010eyz.1_Missense_Mutation_p.D2V	NM_001521	NP_001512	Q8WUA4	TF3C2_HUMAN	general transcription factor IIIC, polypeptide	2						transcription factor TFIIIC complex				ovary(1)|skin(1)	2	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CCCGCAGGTATCCATCAGCAC	0.517		NA											39	70					0	0	0	0
LTBP1	4052	broad.mit.edu	37	2	33588552	33588552	+	Missense_Mutation	SNP	A	A	C			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr2:33588552A>C	uc002ros.2	+	29	4369	c.4369A>C	c.(4369-4371)ACG>CCG	p.T1457P	LTBP1_uc002rot.2_Missense_Mutation_p.T1131P|LTBP1_uc002rou.2_Missense_Mutation_p.T1130P|LTBP1_uc002rov.2_Missense_Mutation_p.T1077P|LTBP1_uc010ymz.1_Missense_Mutation_p.T1088P|LTBP1_uc010yna.1_Missense_Mutation_p.T1035P|LTBP1_uc010ynb.1_Missense_Mutation_p.T354P	NM_206943	NP_996826	Q14766	LTBP1_HUMAN	latent transforming growth factor beta binding	1456	EGF-like 15; calcium-binding (Potential).				negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta	proteinaceous extracellular matrix	calcium ion binding|growth factor binding|transforming growth factor beta receptor activity			ovary(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|central_nervous_system(1)	8	all_hematologic(175;0.115)	Medulloblastoma(90;0.215)				TAAGCAAGGGACGTACTATGA	0.398		NA											14	92					0	0	0	0
PSME4	23198	broad.mit.edu	37	2	54155437	54155437	+	Silent	SNP	T	T	C			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr2:54155437T>C	uc002rxp.2	-	11	1376	c.1320A>G	c.(1318-1320)ACA>ACG	p.T440T	PSME4_uc010yop.1_Silent_p.T326T|PSME4_uc010yoq.1_RNA|PSME4_uc010fbu.1_5'UTR|PSME4_uc010fbv.1_Intron	NM_014614	NP_055429	Q14997	PSME4_HUMAN	proteasome (prosome, macropain) activator	440					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|cell differentiation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|M/G1 transition of mitotic cell cycle|mRNA metabolic process|multicellular organismal development|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|spermatogenesis|viral reproduction	nuclear speck|proteasome complex	binding			ovary(2)|breast(2)|pancreas(1)	5			Lung(47;0.125)|LUSC - Lung squamous cell carcinoma(58;0.181)			ATGCAGGATATGTTCTACAGT	0.353		NA											4	24					0	0	0	0
CNNM3	26505	broad.mit.edu	37	2	97490833	97490833	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr2:97490833G>A	uc002swy.2	+	2	1288	c.1264G>A	c.(1264-1266)GAG>AAG	p.E422K	CNNM3_uc002swz.2_Intron	NM_017623	NP_060093	Q8NE01	CNNM3_HUMAN	cyclin M3 isoform 1	422	CBS 2.				ion transport	integral to membrane|plasma membrane	protein binding			ovary(1)	1						GGTGAACAACGAGGGTGAAGG	0.602		NA											6	34					0	0	0	0
TNFAIP6	7130	broad.mit.edu	37	2	152226720	152226720	+	Missense_Mutation	SNP	A	A	C			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr2:152226720A>C	uc002txk.2	+	4	657	c.581A>C	c.(580-582)GAA>GCA	p.E194A		NM_007115	NP_009046	P98066	TSG6_HUMAN	tumor necrosis factor, alpha-induced protein 6	194	CUB.				cell adhesion|cell-cell signaling|inflammatory response|signal transduction		hyaluronic acid binding				0				BRCA - Breast invasive adenocarcinoma(221;0.131)		GATTATGTTGAAATATATGAC	0.413		NA											32	166					0	0	0	0
PKP4	8502	broad.mit.edu	37	2	159488376	159488376	+	Missense_Mutation	SNP	G	G	T			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr2:159488376G>T	uc002tzv.2	+	8	1525	c.1265G>T	c.(1264-1266)AGC>ATC	p.S422I	PKP4_uc002tzt.1_Missense_Mutation_p.S274I|PKP4_uc002tzu.2_Missense_Mutation_p.S422I|PKP4_uc002tzw.2_Missense_Mutation_p.S422I|PKP4_uc002tzx.2_Missense_Mutation_p.S80I|PKP4_uc002tzy.1_Missense_Mutation_p.S80I|PKP4_uc002tzz.1_Missense_Mutation_p.S420I|PKP4_uc002uaa.2_Missense_Mutation_p.S274I	NM_003628	NP_003619	Q99569	PKP4_HUMAN	plakophilin 4 isoform a	422	ARM 1.				cell adhesion	desmosome	protein binding			ovary(5)|skin(2)	7						ACCTATTACAGCCCAGTGTAC	0.527		NA								HNSCC(62;0.18)			22	62					1.96e-10	2.23e-10	1	0
LRP2	4036	broad.mit.edu	37	2	170060520	170060520	+	Missense_Mutation	SNP	A	A	C	rs78701402		TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr2:170060520A>C	uc002ues.2	-	42	8190	c.7977T>G	c.(7975-7977)AAT>AAG	p.N2659K		NM_004525	NP_004516	P98164	LRP2_HUMAN	low density lipoprotein-related protein 2	2659	EGF-like 10.|Extracellular (Potential).				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			ovary(13)|skin(6)|central_nervous_system(4)|large_intestine(3)|kidney(2)|pancreas(1)	29				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	TGCAGCCCCCATTAAACTGTT	0.428		NA											12	106					0	0	0	0
SP3	6670	broad.mit.edu	37	2	174819640	174819640	+	Missense_Mutation	SNP	T	T	C			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr2:174819640T>C	uc002uig.2	-	4	1764	c.1600A>G	c.(1600-1602)ATA>GTA	p.I534V	SP3_uc002uie.2_Missense_Mutation_p.I466V|SP3_uc002uif.2_Missense_Mutation_p.I481V|SP3_uc010zel.1_Missense_Mutation_p.I531V	NM_003111	NP_003102	Q02447	SP3_HUMAN	Sp3 transcription factor isoform 1	534	Repressor domain.				negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	PML body	protein binding|zinc ion binding		EWSR1/SP3(3)	soft_tissue(3)|upper_aerodigestive_tract(1)|ovary(1)|skin(1)	6			OV - Ovarian serous cystadenocarcinoma(117;0.185)			TGTAGCTGTATACCAGCAGAA	0.423		NA											35	57					0	0	0	0
OLA1	29789	broad.mit.edu	37	2	175006625	175006625	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr2:175006625C>T	uc002uih.2	-	5	663	c.477G>A	c.(475-477)ATG>ATA	p.M159I	OLA1_uc002uii.2_Missense_Mutation_p.M1I|OLA1_uc010fqq.2_Missense_Mutation_p.M159I|OLA1_uc002uij.2_Missense_Mutation_p.M1I|OLA1_uc002uik.2_Missense_Mutation_p.M129I|OLA1_uc010fqr.2_Missense_Mutation_p.M159I	NM_013341	NP_037473	Q9NTK5	OLA1_HUMAN	Obg-like ATPase 1 isoform 1	159					ATP catabolic process	cytoplasm	ATP binding|GTP binding|hydrolase activity|protein binding			ovary(1)|breast(1)	2						TGGGCCCAATCATTTCCTCAT	0.343		NA											16	87					0	0	0	0
TTC30A	92104	broad.mit.edu	37	2	178482633	178482633	+	Missense_Mutation	SNP	T	T	A			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr2:178482633T>A	uc002ulo.2	-	1	1062	c.797A>T	c.(796-798)AAC>ATC	p.N266I		NM_152275	NP_689488	Q86WT1	TT30A_HUMAN	tetratricopeptide repeat domain 30A	266					cell projection organization	cilium	binding				0			OV - Ovarian serous cystadenocarcinoma(117;0.000423)|Epithelial(96;0.00373)|all cancers(119;0.0169)			TACCTCATAGTTTCTCAGTTG	0.507		NA											40	80					0	0	0	0
TTN	7273	broad.mit.edu	37	2	179449963	179449963	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr2:179449963C>T	uc010zfg.1	-	258	57028	c.56804G>A	c.(56803-56805)GGA>GAA	p.G18935E	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.G12630E|TTN_uc010zfi.1_Missense_Mutation_p.G12563E|TTN_uc010zfj.1_Missense_Mutation_p.G12438E	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	19862							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTCATCTTCTCCTTTTTTCCA	0.423		NA											32	189					0	0	0	0
ORC2L	4999	broad.mit.edu	37	2	201798698	201798698	+	Splice_Site	SNP	C	C	T			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr2:201798698C>T	uc002uwr.2	-	10	966	c.709_splice	c.e10-1	p.S237_splice	ORC2L_uc010zhj.1_Splice_Site_p.S237_splice	NM_006190	NP_006181	Q13416	ORC2_HUMAN	origin recognition complex, subunit 2						cell cycle checkpoint|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|negative regulation of transcription from RNA polymerase II promoter|S phase of mitotic cell cycle	nuclear origin of replication recognition complex|nucleoplasm	DNA replication origin binding|protein binding				0						CTAAGTCACTCTGAAAGTGAA	0.348		NA											14	73					0	0	0	0
TMC2	117532	broad.mit.edu	37	20	2621930	2621930	+	Missense_Mutation	SNP	A	A	G			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr20:2621930A>G	uc002wgf.1	+	20	2669	c.2654A>G	c.(2653-2655)CAC>CGC	p.H885R	TMC2_uc002wgg.1_Missense_Mutation_p.H869R	NM_080751	NP_542789	Q8TDI7	TMC2_HUMAN	transmembrane cochlear-expressed protein 2	885	Cytoplasmic (Potential).					integral to membrane				ovary(3)	3						GATTCTGGCCACGCCCCATCT	0.617		NA											3	47					0	0	0	0
ESF1	51575	broad.mit.edu	37	20	13698017	13698017	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr20:13698017C>G	uc002woj.2	-	13	2368	c.2260G>C	c.(2260-2262)GAG>CAG	p.E754Q		NM_016649	NP_057733	Q9H501	ESF1_HUMAN	ABT1-associated protein	754	Lys-rich.|Potential.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus|nucleoplasm				ovary(1)	1						ATGGTTACCTCAAAGTCATCC	0.279		NA											17	830					0	0	0	0
ENTPD6	955	broad.mit.edu	37	20	25199204	25199204	+	Silent	SNP	G	G	A			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr20:25199204G>A	uc002wuj.2	+	10	1077	c.897G>A	c.(895-897)CTG>CTA	p.L299L	ENTPD6_uc010zsy.1_Silent_p.L299L|ENTPD6_uc010gdj.1_Silent_p.L271L|ENTPD6_uc010zsz.1_Silent_p.L81L|ENTPD6_uc002wum.2_Silent_p.L282L|ENTPD6_uc010zta.1_Silent_p.L299L|ENTPD6_uc002wun.2_Silent_p.L299L|ENTPD6_uc002wuk.2_Silent_p.L298L|ENTPD6_uc002wul.2_Silent_p.L298L|ENTPD6_uc010ztb.1_Silent_p.L271L|ENTPD6_uc010ztc.1_Silent_p.L271L|ENTPD6_uc002wuo.2_Silent_p.L51L|ENTPD6_uc010ztd.1_Silent_p.L81L	NM_001247	NP_001238	O75354	ENTP6_HUMAN	ectonucleoside triphosphate diphosphohydrolase 6	299	Lumenal (Potential).					Golgi membrane|integral to membrane	nucleoside-diphosphatase activity				0						GGCTCGGGCTGATGTCGGCAC	0.657		NA											6	9					0	0	0	0
CDH4	1002	broad.mit.edu	37	20	60511842	60511842	+	Silent	SNP	C	C	T			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr20:60511842C>T	uc002ybn.1	+	16	2606	c.2592C>T	c.(2590-2592)TCC>TCT	p.S864S	CDH4_uc002ybp.1_Silent_p.S790S|uc002ybr.1_5'Flank	NM_001794	NP_001785	P55283	CADH4_HUMAN	cadherin 4, type 1 preproprotein	864	Cytoplasmic (Potential).				adherens junction organization|cell junction assembly		calcium ion binding			lung(3)|ovary(2)|skin(1)	6			BRCA - Breast invasive adenocarcinoma(19;2.36e-08)			CCTATGACTCCCTGCTGGTCT	0.637		NA											22	22					0	0	0	0
RNF160	26046	broad.mit.edu	37	21	30357237	30357237	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr21:30357237C>T	uc002ymr.2	-	4	503	c.490G>A	c.(490-492)GAC>AAC	p.D164N	RNF160_uc010gll.1_RNA	NM_015565	NP_056380	O94822	LTN1_HUMAN	zinc finger protein 294	118							ligase activity|zinc ion binding				0						ACGCGACGGTCATGATCCTAT	0.348		NA											10	17					0	0	0	0
DONSON	29980	broad.mit.edu	37	21	34950680	34950680	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr21:34950680G>C	uc002ysk.2	-	10	1701	c.1634C>G	c.(1633-1635)CCG>CGG	p.P545R	DONSON_uc002ysi.1_Missense_Mutation_p.P305R|DONSON_uc002ysj.2_Missense_Mutation_p.P178R|DONSON_uc002ysl.2_Missense_Mutation_p.P178R|DONSON_uc010gme.2_Missense_Mutation_p.P518R|DONSON_uc002ysm.2_Missense_Mutation_p.P545R	NM_017613	NP_060083	Q9NYP3	DONS_HUMAN	downstream neighbor of SON	545					multicellular organismal development	nucleus				ovary(1)|central_nervous_system(1)	2						CCCAAGTAACGGTATTTGACT	0.403		NA											9	71					0	0	0	0
EWSR1	2130	broad.mit.edu	37	22	29695245	29695245	+	Silent	SNP	C	C	T	rs138837921		TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr22:29695245C>T	uc003aet.2	+	15	1930	c.1602C>T	c.(1600-1602)TTC>TTT	p.F534F	EWSR1_uc003aev.2_Silent_p.F539F|EWSR1_uc003aew.2_Silent_p.F478F|EWSR1_uc003aex.2_Silent_p.F533F|EWSR1_uc003aey.2_Silent_p.F329F|EWSR1_uc003aez.2_Silent_p.F195F	NM_005243	NP_005234	Q01844	EWS_HUMAN	Ewing sarcoma breakpoint region 1 isoform 2	534	RanBP2-type.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	calmodulin binding|nucleotide binding|RNA binding|zinc ion binding		EWSR1/FLI1(2266)|EWSR1/ATF1(323)|EWSR1/WT1(231)|EWSR1/ERG(162)|EWSR1/NR4A3(140)|EWSR1/DDIT3(43)|EWSR1/CREB1(42)|EWSR1/FEV(10)|EWSR1/POU5F1(10)|EWSR1/ETV1(7)|EWSR1/ETV4(6)|EWSR1/ZNF384(4)|EWSR1/PBX1(3)|EWSR1/SP3(3)|EWSR1/PATZ1(2)	bone(2526)|soft_tissue(702)|skin(8)|autonomic_ganglia(4)|haematopoietic_and_lymphoid_tissue(4)|salivary_gland(2)|central_nervous_system(2)|NS(2)|pancreas(2)|lung(1)|ovary(1)	3254						ACCAGAACTTCGCCTGGAGAA	0.512		NA	T	FLI1|ERG|ZNF278|NR4A3|FEV|ATF1|ETV1|ETV4|WT1|ZNF384|CREB1|POU5F1| PBX1	Ewing sarcoma| desmoplastic small round cell tumor |ALL|clear cell sarcoma|sarcoma|myoepithelioma								27	102					0	0	0	0
TBC1D10A	83874	broad.mit.edu	37	22	30722697	30722697	+	Silent	SNP	G	G	A			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr22:30722697G>A	uc011akt.1	-	1	198	c.174C>T	c.(172-174)TTC>TTT	p.F58F	TBC1D10A_uc010gvu.2_Silent_p.F58F|TBC1D10A_uc003ahk.3_Silent_p.F58F	NM_031937	NP_114143	Q9BXI6	TB10A_HUMAN	TBC1 domain family, member 10A	58						intracellular|microvillus	guanyl-nucleotide exchange factor activity|PDZ domain binding|Rab GTPase activator activity			ovary(1)	1						CGATGAAGCCGAACTTGTCGA	0.726		NA											10	24					0	0	0	0
CACNA1D	776	broad.mit.edu	37	3	53834348	53834348	+	Nonsense_Mutation	SNP	G	G	T			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr3:53834348G>T	uc003dgv.3	+	41	5159	c.4996G>T	c.(4996-4998)GAG>TAG	p.E1666*	CACNA1D_uc003dgu.3_Nonsense_Mutation_p.E1686*|CACNA1D_uc003dgy.3_Nonsense_Mutation_p.E1651*|CACNA1D_uc003dgw.3_Nonsense_Mutation_p.E1333*|CACNA1D_uc003dgx.1_Nonsense_Mutation_p.E842*|CACNA1D_uc011bes.1_RNA	NM_001128840	NP_001122312	Q01668	CAC1D_HUMAN	calcium channel, voltage-dependent, L type,	1666	Cytoplasmic (Potential).				axon guidance|energy reserve metabolic process|regulation of insulin secretion	voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(6)|upper_aerodigestive_tract(2)|liver(1)|central_nervous_system(1)|skin(1)	11				BRCA - Breast invasive adenocarcinoma(193;0.00029)|KIRC - Kidney renal clear cell carcinoma(284;0.0145)|Kidney(284;0.0175)|OV - Ovarian serous cystadenocarcinoma(275;0.0613)	Verapamil(DB00661)	GCAAGATGACGAGCCTGAGGA	0.463		NA											20	45					1.34e-09	1.51e-09	1	0
PDE12	201626	broad.mit.edu	37	3	57542169	57542169	+	Silent	SNP	G	G	A			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr3:57542169G>A	uc003diw.3	+	1	189	c.63G>A	c.(61-63)CTG>CTA	p.L21L	PDE12_uc003div.2_Silent_p.L21L	NM_177966	NP_808881	Q6L8Q7	PDE12_HUMAN	phosphodiesterase 12	21							hydrolase activity				0				KIRC - Kidney renal clear cell carcinoma(284;0.011)|Kidney(284;0.0127)		TGGAGAAGCTGAGCCGGGCTG	0.692		NA											5	9					0	0	0	0
NFKBIZ	64332	broad.mit.edu	37	3	101573934	101573934	+	Missense_Mutation	SNP	A	A	G			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr3:101573934A>G	uc003dvp.2	+	7	1587	c.1472A>G	c.(1471-1473)AAT>AGT	p.N491S	NFKBIZ_uc003dvo.2_Missense_Mutation_p.N391S|NFKBIZ_uc010hpo.2_Missense_Mutation_p.N391S|NFKBIZ_uc003dvq.2_Missense_Mutation_p.N369S	NM_031419	NP_113607	Q9BYH8	IKBZ_HUMAN	nuclear factor of kappa light polypeptide gene	491	Interaction with NFKB1/p50 (By similarity).|ANK 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				ovary(2)	2						GTGGCTGCCAATCAGCATCTC	0.458		NA											21	102					0	0	0	0
CD96	10225	broad.mit.edu	37	3	111296359	111296359	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr3:111296359G>C	uc003dxw.2	+	4	724	c.554G>C	c.(553-555)AGC>ACC	p.S185T	CD96_uc003dxv.2_Intron|CD96_uc003dxx.2_Intron|CD96_uc010hpy.1_Intron	NM_198196	NP_937839	P40200	TACT_HUMAN	CD96 antigen isoform 1 precursor	185	Extracellular (Potential).|Ig-like V-type 2.				cell adhesion|immune response|regulation of immune response	integral to plasma membrane				skin(2)|central_nervous_system(1)	3						GAAAACAGCAGCACGGATTCT	0.423		NA							Opitz_Trigonocephaly_syndrome				62	331					0	0	0	0
ATP2C1	27032	broad.mit.edu	37	3	130715584	130715584	+	Silent	SNP	C	C	G			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr3:130715584C>G	uc003enl.2	+	24	2409	c.2187C>G	c.(2185-2187)CTC>CTG	p.L729L	ATP2C1_uc011blg.1_Silent_p.L763L|ATP2C1_uc011blh.1_Silent_p.L724L|ATP2C1_uc011bli.1_Silent_p.L763L|ATP2C1_uc003enk.2_Silent_p.L713L|ATP2C1_uc003enm.2_Silent_p.L729L|ATP2C1_uc003enn.2_Silent_p.L713L|ATP2C1_uc003eno.2_Silent_p.L729L|ATP2C1_uc003enp.2_Silent_p.L729L|ATP2C1_uc003enq.2_Silent_p.L729L|ATP2C1_uc003enr.2_Silent_p.L729L|ATP2C1_uc003ens.2_Silent_p.L729L|ATP2C1_uc003ent.2_Silent_p.L729L|ATP2C1_uc003enu.2_Silent_p.L407L	NM_014382	NP_055197	P98194	AT2C1_HUMAN	calcium-transporting ATPase 2C1 isoform 1a	729	Lumenal (By similarity).				actin cytoskeleton reorganization|ATP biosynthetic process|calcium-dependent cell-cell adhesion|cellular calcium ion homeostasis|cellular manganese ion homeostasis|epidermis development|Golgi calcium ion homeostasis|Golgi calcium ion transport|positive regulation of I-kappaB kinase/NF-kappaB cascade	Golgi apparatus|Golgi membrane|integral to membrane|trans-Golgi network	ATP binding|ATP binding|calcium ion binding|calcium-transporting ATPase activity|manganese ion binding|manganese-transporting ATPase activity|metal ion binding|signal transducer activity			skin(1)	1					Arsenic trioxide(DB01169)|Desflurane(DB01189)|Enflurane(DB00228)|Halothane(DB01159)|Isoflurane(DB00753)|Methoxyflurane(DB01028)|Miconazole(DB01110)|Sevoflurane(DB01236)	CTAATCCTCTCAATGCCATGC	0.363		NA							Hailey-Hailey_disease				35	85					0	0	0	0
NPHP3	27031	broad.mit.edu	37	3	132435736	132435736	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr3:132435736C>T	uc003epe.1	-	4	765	c.688G>A	c.(688-690)GAA>AAA	p.E230K	NPHP3_uc003epf.1_5'UTR	NM_153240	NP_694972	Q7Z494	NPHP3_HUMAN	nephrocystin 3	230					maintenance of organ identity|negative regulation of canonical Wnt receptor signaling pathway|photoreceptor cell maintenance|regulation of Wnt receptor signaling pathway, planar cell polarity pathway|Wnt receptor signaling pathway	cilium	protein binding			ovary(1)	1						GTCCAATATTCACATTGGGTT	0.443		NA											15	74					0	0	0	0
KY	339855	broad.mit.edu	37	3	134323141	134323141	+	Silent	SNP	G	G	A			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr3:134323141G>A	uc010hty.2	-	11	1328	c.1266C>T	c.(1264-1266)TCC>TCT	p.S422S	KY_uc011blw.1_3'UTR|KY_uc011blx.1_Silent_p.S401S	NM_178554	NP_848649	Q8NBH2	KY_HUMAN	kyphoscoliosis peptidase	422						cytoskeleton|Z disc	peptidase activity			ovary(2)	2						TGTAGATGTCGGAGTTGCCCT	0.562		NA											8	60					0	0	0	0
AP2M1	1173	broad.mit.edu	37	3	183894784	183894784	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr3:183894784G>C	uc011bqx.1	+	2	160	c.3G>C	c.(1-3)ATG>ATC	p.M1I	AP2M1_uc003fmw.2_Missense_Mutation_p.M1I|AP2M1_uc003fmx.2_Missense_Mutation_p.M1I|AP2M1_uc003fmy.2_Missense_Mutation_p.M1I	NM_004068	NP_004059	Q96CW1	AP2M1_HUMAN	adaptor-related protein complex 2, mu 1 subunit	1					axon guidance|cellular membrane organization|epidermal growth factor receptor signaling pathway|intracellular protein transport|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|regulation of defense response to virus by virus|synaptic transmission|vesicle-mediated transport|viral reproduction	clathrin adaptor complex|clathrin coat of coated pit|cytosol|endocytic vesicle membrane|peroxisomal membrane	lipid binding|protein binding|transporter activity				0	all_cancers(143;1.12e-10)|Ovarian(172;0.0339)		Epithelial(37;2.92e-34)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			CTGCCGCCATGATTGGAGGCT	0.582		NA											6	38					0	0	0	0
DGKQ	1609	broad.mit.edu	37	4	959312	959312	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr4:959312C>T	uc003gbw.2	-	14	1659	c.1585G>A	c.(1585-1587)GTG>ATG	p.V529M	DGKQ_uc010ibn.2_Intron	NM_001347	NP_001338	P52824	DGKQ_HUMAN	diacylglycerol kinase, theta	529					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|platelet activation|protein kinase C signaling cascade|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to ATP|thrombin receptor signaling pathway	cytoskeleton|cytosol|nuclear speck|plasma membrane	activating transcription factor binding|ATP binding|diacylglycerol kinase activity|kinase binding|metal ion binding|phospholipase binding			kidney(1)	1			OV - Ovarian serous cystadenocarcinoma(23;0.0158)			ACGGACACCACGGTGGCTGCA	0.652		NA											3	25					0	0	0	0
CRIPAK	285464	broad.mit.edu	37	4	1389375	1389375	+	Missense_Mutation	SNP	T	T	C	rs35263928		TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr4:1389375T>C	uc003gdf.2	+	1	4036	c.1076T>C	c.(1075-1077)GTG>GCG	p.V359A		NM_175918	NP_787114	Q8N1N5	CRPAK_HUMAN	cysteine-rich PAK1 inhibitor	359					ER-nucleus signaling pathway|negative regulation of protein kinase activity|regulation of cytoskeleton organization|response to estrogen stimulus	endoplasmic reticulum|nucleus|plasma membrane	protein binding				0			OV - Ovarian serous cystadenocarcinoma(23;0.0106)			CGTGCCCATGTGGAGTGCCCG	0.652		NA											4	202					0	0	0	0
SLC2A9	56606	broad.mit.edu	37	4	9828063	9828063	+	Silent	SNP	G	G	A			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr4:9828063G>A	uc003gmc.2	-	12	1642	c.1581C>T	c.(1579-1581)ATC>ATT	p.I527I	SLC2A9_uc003gmd.2_Silent_p.I498I	NM_020041	NP_064425	Q9NRM0	GTR9_HUMAN	solute carrier family 2, member 9 protein	527	Cytoplasmic (Potential).				glucose transport|urate metabolic process	integral to membrane|plasma membrane	sugar:hydrogen symporter activity			ovary(3)	3						CAGCTGAGTCGATTTTCTCTT	0.423		NA											40	77					0	0	0	0
NKX3-2	579	broad.mit.edu	37	4	13544126	13544126	+	Missense_Mutation	SNP	C	C	T	rs61795263		TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr4:13544126C>T	uc003gmx.2	-	2	569	c.493G>A	c.(493-495)GAC>AAC	p.D165N		NM_001189	NP_001180	P78367	NKX32_HUMAN	NK3 homeobox 2	165					negative regulation of chondrocyte differentiation|transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						CCAACACCGTCGTCCTCGGTC	0.463		NA											4	20					0	0	0	0
PF4	5196	broad.mit.edu	37	4	74846999	74846999	+	Silent	SNP	C	C	T			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr4:74846999C>T	uc003hhi.2	-	3	273	c.228G>A	c.(226-228)CTG>CTA	p.L76L		NM_002619	NP_002610	P02776	PLF4_HUMAN	platelet factor 4 (chemokine (C-X-C motif)	76					cytokine-mediated signaling pathway|immune response|leukocyte chemotaxis|negative regulation of angiogenesis|negative regulation of apoptosis|negative regulation of cytolysis|negative regulation of megakaryocyte differentiation|negative regulation of MHC class II biosynthetic process|platelet activation|platelet degranulation|positive regulation of gene expression|positive regulation of macrophage derived foam cell differentiation|positive regulation of macrophage differentiation|positive regulation of tumor necrosis factor production	extracellular space|platelet alpha granule lumen	chemokine activity|heparin binding				0	Breast(15;0.00136)		all cancers(17;0.0034)|Lung(101;0.196)		Drotrecogin alfa(DB00055)	TTCCATTCTTCAGCGTGGCTC	0.488		NA											9	87					0	0	0	0
KLHL8	57563	broad.mit.edu	37	4	88106900	88106900	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr4:88106900G>A	uc011cdb.1	-	3	653	c.268C>T	c.(268-270)CCC>TCC	p.P90S	KLHL8_uc003hql.1_Missense_Mutation_p.P90S|KLHL8_uc003hqm.1_Intron|KLHL8_uc003hqn.1_Intron|KLHL8_uc010ikj.1_Intron	NM_020803	NP_065854	Q9P2G9	KLHL8_HUMAN	kelch-like 8	90	BTB.										0		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.242)		OV - Ovarian serous cystadenocarcinoma(123;0.000603)		CTAAAGTAGGGAATAACACAA	0.373		NA											6	11					0	0	0	0
FAT1	2195	broad.mit.edu	37	4	187538164	187538164	+	Nonsense_Mutation	SNP	C	C	A			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr4:187538164C>A	uc003izf.2	-	11	9258	c.9070G>T	c.(9070-9072)GAA>TAA	p.E3024*		NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor	3024	Extracellular (Potential).|Cadherin 28.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12						CTTACCTTTTCACAAACTGGA	0.388		NA								HNSCC(5;0.00058)			13	22					7.93e-07	8.71e-07	1	0
NUDT12	83594	broad.mit.edu	37	5	102894586	102894586	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr5:102894586C>G	uc003koi.2	-	3	883	c.790G>C	c.(790-792)GAA>CAA	p.E264Q	NUDT12_uc011cvb.1_Missense_Mutation_p.E246Q	NM_031438	NP_113626	Q9BQG2	NUD12_HUMAN	nudix-type motif 12	264						nucleus|peroxisome	metal ion binding|NAD+ diphosphatase activity				0		all_cancers(142;6.38e-08)|all_epithelial(76;1.99e-10)|Prostate(80;0.0138)|Lung NSC(167;0.0212)|Colorectal(57;0.0247)|all_lung(232;0.0283)|Ovarian(225;0.0423)		Epithelial(69;9.3e-13)|COAD - Colon adenocarcinoma(37;0.0221)		TTACCAGCTTCTTTTTCTTTC	0.373		NA											3	7					0	0	0	0
APC	324	broad.mit.edu	37	5	112176368	112176368	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr5:112176368G>A	uc010jby.2	+	16	5457	c.5077G>A	c.(5077-5079)GAA>AAA	p.E1693K	APC_uc011cvt.1_Missense_Mutation_p.E1675K|APC_uc003kpz.3_Missense_Mutation_p.E1693K|APC_uc003kpy.3_Missense_Mutation_p.E1693K|APC_uc010jbz.2_Missense_Mutation_p.E1410K|APC_uc010jca.2_Missense_Mutation_p.E993K	NM_001127511	NP_001120983	P25054	APC_HUMAN	adenomatous polyposis coli	1693	Ser-rich.				canonical Wnt receptor signaling pathway|cell adhesion|cell cycle arrest|cell migration|cellular component disassembly involved in apoptosis|cytokinesis after mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cyclin-dependent protein kinase activity|negative regulation of microtubule depolymerization|positive regulation of apoptosis|positive regulation of cell migration|positive regulation of pseudopodium assembly|protein complex assembly|regulation of attachment of spindle microtubules to kinetochore|response to DNA damage stimulus|tight junction assembly	adherens junction|APC-Axin-1-beta-catenin complex|Axin-APC-beta-catenin-GSK3B complex|beta-catenin destruction complex|centrosome|cytosol|kinetochore|lamellipodium|lateral plasma membrane|nucleus|ruffle membrane|tight junction	beta-catenin binding|gamma-catenin binding|microtubule plus-end binding|protein kinase binding|protein kinase regulator activity	p.K1192fs*3(1)|p.?(1)		large_intestine(2123)|stomach(123)|soft_tissue(55)|small_intestine(34)|breast(26)|pancreas(25)|urinary_tract(20)|lung(19)|thyroid(18)|liver(13)|central_nervous_system(10)|ovary(9)|skin(7)|upper_aerodigestive_tract(6)|adrenal_gland(6)|bone(6)|NS(5)|prostate(4)|endometrium(3)|kidney(1)|oesophagus(1)|biliary_tract(1)	2515		all_cancers(142;3.01e-27)|all_epithelial(76;2.3e-18)|all_hematologic(541;4.32e-09)|Ovarian(225;1.78e-06)|Lung NSC(167;0.000195)|Breast(839;0.000231)|all_lung(232;0.000247)|Colorectal(10;0.000355)|Prostate(80;0.00133)		OV - Ovarian serous cystadenocarcinoma(64;1.09e-113)|Epithelial(69;3.79e-112)|all cancers(49;1.67e-104)|BRCA - Breast invasive adenocarcinoma(61;0.00136)|COAD - Colon adenocarcinoma(37;0.00155)|Colorectal(14;0.00191)		CATTCCTACAGAAGGCAGAAG	0.438		12	D|Mis|N|F|S		colorectal|pancreatic|desmoid|hepatoblastoma|glioma|other CNS	colorectal|pancreatic|desmoid|hepatoblastoma|glioma|other CNS			Hereditary_Desmoid_Disease|Familial_Adenomatous_Polyposis|Turcot_syndrome	TSP Lung(16;0.13)			4	17					0	0	0	0
APC	324	broad.mit.edu	37	5	112177885	112177885	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr5:112177885G>C	uc010jby.2	+	16	6974	c.6594G>C	c.(6592-6594)TTG>TTC	p.L2198F	APC_uc011cvt.1_Missense_Mutation_p.L2180F|APC_uc003kpz.3_Missense_Mutation_p.L2198F|APC_uc003kpy.3_Missense_Mutation_p.L2198F|APC_uc010jbz.2_Missense_Mutation_p.L1915F|APC_uc010jca.2_Missense_Mutation_p.L1498F	NM_001127511	NP_001120983	P25054	APC_HUMAN	adenomatous polyposis coli	2198	Ser-rich.				canonical Wnt receptor signaling pathway|cell adhesion|cell cycle arrest|cell migration|cellular component disassembly involved in apoptosis|cytokinesis after mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cyclin-dependent protein kinase activity|negative regulation of microtubule depolymerization|positive regulation of apoptosis|positive regulation of cell migration|positive regulation of pseudopodium assembly|protein complex assembly|regulation of attachment of spindle microtubules to kinetochore|response to DNA damage stimulus|tight junction assembly	adherens junction|APC-Axin-1-beta-catenin complex|Axin-APC-beta-catenin-GSK3B complex|beta-catenin destruction complex|centrosome|cytosol|kinetochore|lamellipodium|lateral plasma membrane|nucleus|ruffle membrane|tight junction	beta-catenin binding|gamma-catenin binding|microtubule plus-end binding|protein kinase binding|protein kinase regulator activity	p.?(1)		large_intestine(2123)|stomach(123)|soft_tissue(55)|small_intestine(34)|breast(26)|pancreas(25)|urinary_tract(20)|lung(19)|thyroid(18)|liver(13)|central_nervous_system(10)|ovary(9)|skin(7)|upper_aerodigestive_tract(6)|adrenal_gland(6)|bone(6)|NS(5)|prostate(4)|endometrium(3)|kidney(1)|oesophagus(1)|biliary_tract(1)	2515		all_cancers(142;3.01e-27)|all_epithelial(76;2.3e-18)|all_hematologic(541;4.32e-09)|Ovarian(225;1.78e-06)|Lung NSC(167;0.000195)|Breast(839;0.000231)|all_lung(232;0.000247)|Colorectal(10;0.000355)|Prostate(80;0.00133)		OV - Ovarian serous cystadenocarcinoma(64;1.09e-113)|Epithelial(69;3.79e-112)|all cancers(49;1.67e-104)|BRCA - Breast invasive adenocarcinoma(61;0.00136)|COAD - Colon adenocarcinoma(37;0.00155)|Colorectal(14;0.00191)		ATAAAAGTTTGATTACTGGAA	0.358		12	D|Mis|N|F|S		colorectal|pancreatic|desmoid|hepatoblastoma|glioma|other CNS	colorectal|pancreatic|desmoid|hepatoblastoma|glioma|other CNS			Hereditary_Desmoid_Disease|Familial_Adenomatous_Polyposis|Turcot_syndrome	TSP Lung(16;0.13)			13	36					0	0	0	0
APC	324	broad.mit.edu	37	5	112178407	112178407	+	Missense_Mutation	SNP	G	G	T			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr5:112178407G>T	uc010jby.2	+	16	7496	c.7116G>T	c.(7114-7116)CAG>CAT	p.Q2372H	APC_uc011cvt.1_Missense_Mutation_p.Q2354H|APC_uc003kpz.3_Missense_Mutation_p.Q2372H|APC_uc003kpy.3_Missense_Mutation_p.Q2372H|APC_uc010jbz.2_Missense_Mutation_p.Q2089H|APC_uc010jca.2_Missense_Mutation_p.Q1672H	NM_001127511	NP_001120983	P25054	APC_HUMAN	adenomatous polyposis coli	2372	Ser-rich.				canonical Wnt receptor signaling pathway|cell adhesion|cell cycle arrest|cell migration|cellular component disassembly involved in apoptosis|cytokinesis after mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cyclin-dependent protein kinase activity|negative regulation of microtubule depolymerization|positive regulation of apoptosis|positive regulation of cell migration|positive regulation of pseudopodium assembly|protein complex assembly|regulation of attachment of spindle microtubules to kinetochore|response to DNA damage stimulus|tight junction assembly	adherens junction|APC-Axin-1-beta-catenin complex|Axin-APC-beta-catenin-GSK3B complex|beta-catenin destruction complex|centrosome|cytosol|kinetochore|lamellipodium|lateral plasma membrane|nucleus|ruffle membrane|tight junction	beta-catenin binding|gamma-catenin binding|microtubule plus-end binding|protein kinase binding|protein kinase regulator activity	p.?(1)		large_intestine(2123)|stomach(123)|soft_tissue(55)|small_intestine(34)|breast(26)|pancreas(25)|urinary_tract(20)|lung(19)|thyroid(18)|liver(13)|central_nervous_system(10)|ovary(9)|skin(7)|upper_aerodigestive_tract(6)|adrenal_gland(6)|bone(6)|NS(5)|prostate(4)|endometrium(3)|kidney(1)|oesophagus(1)|biliary_tract(1)	2515		all_cancers(142;3.01e-27)|all_epithelial(76;2.3e-18)|all_hematologic(541;4.32e-09)|Ovarian(225;1.78e-06)|Lung NSC(167;0.000195)|Breast(839;0.000231)|all_lung(232;0.000247)|Colorectal(10;0.000355)|Prostate(80;0.00133)		OV - Ovarian serous cystadenocarcinoma(64;1.09e-113)|Epithelial(69;3.79e-112)|all cancers(49;1.67e-104)|BRCA - Breast invasive adenocarcinoma(61;0.00136)|COAD - Colon adenocarcinoma(37;0.00155)|Colorectal(14;0.00191)		CAGGTAGACAGATGAGCCAAC	0.403		12	D|Mis|N|F|S		colorectal|pancreatic|desmoid|hepatoblastoma|glioma|other CNS	colorectal|pancreatic|desmoid|hepatoblastoma|glioma|other CNS			Hereditary_Desmoid_Disease|Familial_Adenomatous_Polyposis|Turcot_syndrome	TSP Lung(16;0.13)			14	34					1.58e-08	1.77e-08	1	0
APC	324	broad.mit.edu	37	5	112178579	112178579	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr5:112178579G>C	uc010jby.2	+	16	7668	c.7288G>C	c.(7288-7290)GAT>CAT	p.D2430H	APC_uc011cvt.1_Missense_Mutation_p.D2412H|APC_uc003kpz.3_Missense_Mutation_p.D2430H|APC_uc003kpy.3_Missense_Mutation_p.D2430H|APC_uc010jbz.2_Missense_Mutation_p.D2147H|APC_uc010jca.2_Missense_Mutation_p.D1730H	NM_001127511	NP_001120983	P25054	APC_HUMAN	adenomatous polyposis coli	2430	Ser-rich.				canonical Wnt receptor signaling pathway|cell adhesion|cell cycle arrest|cell migration|cellular component disassembly involved in apoptosis|cytokinesis after mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cyclin-dependent protein kinase activity|negative regulation of microtubule depolymerization|positive regulation of apoptosis|positive regulation of cell migration|positive regulation of pseudopodium assembly|protein complex assembly|regulation of attachment of spindle microtubules to kinetochore|response to DNA damage stimulus|tight junction assembly	adherens junction|APC-Axin-1-beta-catenin complex|Axin-APC-beta-catenin-GSK3B complex|beta-catenin destruction complex|centrosome|cytosol|kinetochore|lamellipodium|lateral plasma membrane|nucleus|ruffle membrane|tight junction	beta-catenin binding|gamma-catenin binding|microtubule plus-end binding|protein kinase binding|protein kinase regulator activity	p.?(1)		large_intestine(2123)|stomach(123)|soft_tissue(55)|small_intestine(34)|breast(26)|pancreas(25)|urinary_tract(20)|lung(19)|thyroid(18)|liver(13)|central_nervous_system(10)|ovary(9)|skin(7)|upper_aerodigestive_tract(6)|adrenal_gland(6)|bone(6)|NS(5)|prostate(4)|endometrium(3)|kidney(1)|oesophagus(1)|biliary_tract(1)	2515		all_cancers(142;3.01e-27)|all_epithelial(76;2.3e-18)|all_hematologic(541;4.32e-09)|Ovarian(225;1.78e-06)|Lung NSC(167;0.000195)|Breast(839;0.000231)|all_lung(232;0.000247)|Colorectal(10;0.000355)|Prostate(80;0.00133)		OV - Ovarian serous cystadenocarcinoma(64;1.09e-113)|Epithelial(69;3.79e-112)|all cancers(49;1.67e-104)|BRCA - Breast invasive adenocarcinoma(61;0.00136)|COAD - Colon adenocarcinoma(37;0.00155)|Colorectal(14;0.00191)		AAGTGAATCTGATAGATCAGA	0.373		12	D|Mis|N|F|S		colorectal|pancreatic|desmoid|hepatoblastoma|glioma|other CNS	colorectal|pancreatic|desmoid|hepatoblastoma|glioma|other CNS			Hereditary_Desmoid_Disease|Familial_Adenomatous_Polyposis|Turcot_syndrome	TSP Lung(16;0.13)			17	34					0	0	0	0
PCDHB10	56126	broad.mit.edu	37	5	140572793	140572793	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr5:140572793C>G	uc003lix.2	+	1	842	c.668C>G	c.(667-669)TCT>TGT	p.S223C		NM_018930	NP_061753	Q9UN67	PCDBA_HUMAN	protocadherin beta 10 precursor	223	Cadherin 2.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			ovary(1)|skin(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CCATCCAGGTCTGGGACCTCT	0.552		NA											28	70					0	0	0	0
GRIA1	2890	broad.mit.edu	37	5	153085627	153085627	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr5:153085627G>A	uc003lva.3	+	11	2188	c.1823G>A	c.(1822-1824)AGG>AAG	p.R608K	GRIA1_uc003luy.3_Missense_Mutation_p.R608K|GRIA1_uc003luz.3_Missense_Mutation_p.R513K|GRIA1_uc011dcv.1_RNA|GRIA1_uc011dcw.1_Missense_Mutation_p.R528K|GRIA1_uc011dcx.1_Missense_Mutation_p.R539K|GRIA1_uc011dcy.1_Missense_Mutation_p.R618K|GRIA1_uc011dcz.1_Missense_Mutation_p.R618K|GRIA1_uc010jia.1_Missense_Mutation_p.R588K	NM_001114183	NP_001107655	P42261	GRIA1_HUMAN	glutamate receptor, ionotropic, AMPA 1 isoform	608	Cytoplasmic (Potential).				synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|dendritic spine|endocytic vesicle membrane|endoplasmic reticulum membrane|neuronal cell body|postsynaptic density|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity|PDZ domain binding			ovary(4)|skin(2)	6		Medulloblastoma(196;0.0391)|all_neural(177;0.16)|all_hematologic(541;0.21)	Kidney(363;0.000173)|KIRC - Kidney renal clear cell carcinoma(527;0.000785)		Desflurane(DB01189)|Enflurane(DB00228)|Halothane(DB01159)|Isoflurane(DB00753)|L-Glutamic Acid(DB00142)|Methoxyflurane(DB01028)|Sevoflurane(DB01236)	ATTTCTCCCAGGTCAGTCAGC	0.373		NA											31	22					0	0	0	0
WWC1	23286	broad.mit.edu	37	5	167887709	167887709	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr5:167887709C>T	uc003lzu.2	+	20	2971	c.2878C>T	c.(2878-2880)CGA>TGA	p.R960*	WWC1_uc003lzv.2_Nonsense_Mutation_p.R960*|WWC1_uc011den.1_Nonsense_Mutation_p.R960*|WWC1_uc003lzw.2_Nonsense_Mutation_p.R759*|WWC1_uc010jjf.1_Nonsense_Mutation_p.R232*	NM_015238	NP_056053	Q8IX03	KIBRA_HUMAN	WW and C2 domain containing 1 isoform 3	960	Interaction with PRKCZ.|Interaction with histone H3.				cell migration|positive regulation of MAPKKK cascade|regulation of hippo signaling cascade|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|perinuclear region of cytoplasm|ruffle membrane	protein binding|transcription coactivator activity			ovary(2)|skin(2)|breast(1)	5	Renal(175;0.000212)|Lung NSC(126;0.0875)|all_lung(126;0.166)	Medulloblastoma(196;0.0399)|all_neural(177;0.0577)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0364)|Epithelial(171;0.0765)|OV - Ovarian serous cystadenocarcinoma(192;0.0918)		ACCTTTTGTTCGAAACTCCCT	0.507		NA											13	11					0	0	0	0
DOCK2	1794	broad.mit.edu	37	5	169144446	169144446	+	Missense_Mutation	SNP	A	A	G			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr5:169144446A>G	uc003maf.2	+	21	2170	c.2090A>G	c.(2089-2091)GAG>GGG	p.E697G	DOCK2_uc011der.1_RNA|DOCK2_uc010jjm.2_Missense_Mutation_p.E189G	NM_004946	NP_004937	Q92608	DOCK2_HUMAN	dedicator of cytokinesis 2	697					actin cytoskeleton organization|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|endomembrane system|membrane	electron carrier activity|GTP binding|GTPase binding|heme binding|Rac guanyl-nucleotide exchange factor activity|T cell receptor binding			ovary(5)|pancreas(2)	7	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			ACCGTTCTGGAGGCTTACATC	0.463		NA											7	137					0	0	0	0
RIPK1	8737	broad.mit.edu	37	6	3105891	3105891	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr6:3105891G>C	uc010jni.2	+	9	1414	c.1182G>C	c.(1180-1182)CAG>CAC	p.Q394H	RIPK1_uc003muv.3_Missense_Mutation_p.Q231H|RIPK1_uc003muw.3_Missense_Mutation_p.Q329H|RIPK1_uc011dhs.1_Missense_Mutation_p.Q348H|RIPK1_uc003mux.2_Missense_Mutation_p.Q394H	NM_003804	NP_003795	Q13546	RIPK1_HUMAN	receptor (TNFRSF)-interacting serine-threonine	394	Interaction with SQSTM1.				activation of caspase activity|activation of JUN kinase activity|activation of pro-apoptotic gene products|induction of apoptosis by extracellular signals|induction of necroptosis by extracellular signals|innate immune response|MyD88-independent toll-like receptor signaling pathway|positive regulation of anti-apoptosis|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-8 production|positive regulation of NF-kappaB transcription factor activity|positive regulation of reactive oxygen species metabolic process|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|protein autophosphorylation|regulation of ATP:ADP antiporter activity|Toll signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|death-inducing signaling complex|endosome membrane|mitochondrion|receptor complex	ATP binding|death domain binding|death receptor binding|protein serine/threonine kinase activity			large_intestine(3)|lung(1)|skin(1)	5	Ovarian(93;0.0386)	all_hematologic(90;0.0895)				TGGACAGGCAGACGAAACAGC	0.532		NA											26	65					0	0	0	0
HIVEP1	3096	broad.mit.edu	37	6	12122650	12122650	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr6:12122650C>G	uc003nac.2	+	4	2801	c.2622C>G	c.(2620-2622)TTC>TTG	p.F874L	HIVEP1_uc011diq.1_RNA	NM_002114	NP_002105	P15822	ZEP1_HUMAN	human immunodeficiency virus type I enhancer	874					transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|protein binding|zinc ion binding			ovary(3)|large_intestine(1)|central_nervous_system(1)|skin(1)	6	Breast(50;0.0639)|Ovarian(93;0.0816)	all_hematologic(90;0.117)				TTGGCACTTTCTATGATGATG	0.473		NA											24	134					0	0	0	0
HIST1H2BD	3017	broad.mit.edu	37	6	26158508	26158508	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr6:26158508C>G	uc003ngr.2	+	1	160	c.111C>G	c.(109-111)AGC>AGG	p.S37R	HIST1H2BD_uc003ngs.2_Missense_Mutation_p.S37R	NM_021063	NP_066407	P58876	H2B1D_HUMAN	histone cluster 1, H2bd	37					nucleosome assembly	nucleosome|nucleus	DNA binding			ovary(1)|pancreas(1)	2						GCAAGGAGAGCTATTCAGTGT	0.542		NA											17	166					0	0	0	0
TAF8	129685	broad.mit.edu	37	6	42036204	42036204	+	Silent	SNP	G	G	A			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr6:42036204G>A	uc003ors.2	+	7	668	c.639G>A	c.(637-639)TTG>TTA	p.L213L	TAF8_uc003ort.2_Silent_p.L213L|TAF8_uc003oru.1_Silent_p.L213L|TAF8_uc003orv.1_Silent_p.L213L|TAF8_uc011dun.1_Intron	NM_138572	NP_612639	Q7Z7C8	TAF8_HUMAN	TBP-associated factor 8	213					cell differentiation|maintenance of protein location in nucleus|positive regulation of transcription, DNA-dependent|regulation of fat cell differentiation|transcription, DNA-dependent	perinuclear region of cytoplasm|transcription factor TFIID complex	DNA binding|protein binding			ovary(1)	1	Colorectal(47;0.196)		STAD - Stomach adenocarcinoma(11;0.000204)|Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)|Epithelial(12;0.00179)			ATTCGCCAGTGATTGCTGCCA	0.522		NA											54	395					0	0	0	0
ABCC10	89845	broad.mit.edu	37	6	43413457	43413457	+	Missense_Mutation	SNP	G	G	T			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr6:43413457G>T	uc003ouy.1	+	15	3366	c.3151G>T	c.(3151-3153)GCA>TCA	p.A1051S	ABCC10_uc003ouz.1_Missense_Mutation_p.A1023S|ABCC10_uc010jyo.1_Missense_Mutation_p.A157S	NM_033450	NP_258261	Q5T3U5	MRP7_HUMAN	ATP-binding cassette, sub-family C, member 10	1051	ABC transmembrane type-1 2.|Helical; (Potential).					integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(6)|central_nervous_system(1)	7	all_lung(25;0.00536)		Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0152)|OV - Ovarian serous cystadenocarcinoma(102;0.0804)			GGCCAACGCGGCAGGCCTGCT	0.647		NA											8	56					0.000157383	0.000167353	1	0
HTR1E	3354	broad.mit.edu	37	6	87726086	87726086	+	Missense_Mutation	SNP	C	C	A			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr6:87726086C>A	uc003pli.2	+	2	1737	c.1034C>A	c.(1033-1035)ACG>AAG	p.T345K		NM_000865	NP_000856	P28566	5HT1E_HUMAN	5-hydroxytryptamine (serotonin) receptor 1E	345	Helical; Name=7; (By similarity).				G-protein signaling, coupled to cyclic nucleotide second messenger|synaptic transmission	integral to plasma membrane	protein binding|serotonin binding|serotonin receptor activity			ovary(2)|skin(1)	3		all_cancers(76;7.11e-06)|Acute lymphoblastic leukemia(125;1.2e-09)|Prostate(29;3.51e-09)|all_hematologic(105;7.43e-06)|all_epithelial(107;0.00819)		BRCA - Breast invasive adenocarcinoma(108;0.055)	Eletriptan(DB00216)	CTGCTCTATACGAGTTTTAAT	0.438		NA											14	51					2e-07	2.22e-07	1	0
EPHA7	2045	broad.mit.edu	37	6	94120310	94120310	+	Silent	SNP	C	C	T			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr6:94120310C>T	uc003poe.2	-	3	982	c.741G>A	c.(739-741)AGG>AGA	p.R247R	EPHA7_uc003pof.2_Silent_p.R247R|EPHA7_uc011eac.1_Silent_p.R247R|EPHA7_uc003pog.3_Silent_p.R247R	NM_004440	NP_004431	Q15375	EPHA7_HUMAN	ephrin receptor EphA7 precursor	247	Extracellular (Potential).|Cys-rich.					integral to plasma membrane	ATP binding|ephrin receptor activity			lung(8)|ovary(7)|upper_aerodigestive_tract(3)|central_nervous_system(3)|skin(3)|large_intestine(2)|stomach(1)|pancreas(1)	28		all_cancers(76;7.47e-10)|Acute lymphoblastic leukemia(125;1.88e-09)|all_hematologic(75;1.75e-07)|all_epithelial(107;3.6e-05)|Lung NSC(302;0.0368)|all_lung(197;0.0509)|Colorectal(196;0.142)		BRCA - Breast invasive adenocarcinoma(108;0.0847)		TGCAGTGCATCCTGGGGGCGT	0.473		NA											9	37					0	0	0	0
FOXO3	2309	broad.mit.edu	37	6	108984767	108984767	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr6:108984767G>C	uc003psk.2	+	3	1047	c.731G>C	c.(730-732)GGA>GCA	p.G244A	FOXO3_uc003psn.2_Intron|FOXO3_uc003psm.2_Missense_Mutation_p.G244A|FOXO3_uc011ean.1_Missense_Mutation_p.G24A|FOXO3_uc010kdj.1_Missense_Mutation_p.G24A	NM_201559	NP_963853	O43524	FOXO3_HUMAN	forkhead box O3A	244	Fork-head.|Nuclear localization signal.			PDGGKSGKA -> LMGEERKT (in Ref. 5; CAA04860).	antral ovarian follicle growth|apoptosis|embryo development|glucose homeostasis|induction of apoptosis|initiation of primordial ovarian follicle growth|insulin receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|nerve growth factor receptor signaling pathway|oocyte maturation|ovulation from ovarian follicle|pattern specification process|phosphatidylinositol-mediated signaling|positive regulation of erythrocyte differentiation|positive regulation of transcription from RNA polymerase II promoter|regulation of cell proliferation|regulation of sequence-specific DNA binding transcription factor activity|tissue development	cytosol|transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|protein kinase binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription factor binding			central_nervous_system(4)|lung(2)	6		all_cancers(87;1.78e-07)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;3.88e-05)|Colorectal(196;0.0294)|all_lung(197;0.0487)|Lung SC(18;0.152)		Epithelial(106;0.000759)|all cancers(137;0.00121)|BRCA - Breast invasive adenocarcinoma(108;0.00163)|OV - Ovarian serous cystadenocarcinoma(136;0.00718)		GGGAAGAGCGGAAAAGCCCCC	0.592		NA											9	19					0	0	0	0
ROS1	6098	broad.mit.edu	37	6	117681060	117681060	+	Missense_Mutation	SNP	A	A	G			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr6:117681060A>G	uc003pxp.1	-	23	3759	c.3560T>C	c.(3559-3561)GTT>GCT	p.V1187A	ROS1_uc011ebi.1_RNA|GOPC_uc003pxq.1_Intron	NM_002944	NP_002935	P08922	ROS_HUMAN	proto-oncogene c-ros-1 protein precursor	1187	Extracellular (Potential).				transmembrane receptor protein tyrosine kinase signaling pathway	membrane fraction|sodium:potassium-exchanging ATPase complex	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(8)|ovary(6)|central_nervous_system(3)|skin(3)|stomach(2)|breast(2)|large_intestine(1)	25		all_cancers(87;0.00846)|all_epithelial(87;0.0242)		GBM - Glioblastoma multiforme(226;0.0387)|OV - Ovarian serous cystadenocarcinoma(136;0.0954)|all cancers(137;0.137)		TGTGTAGCAAACGGCACTGAT	0.403		NA	T	GOPC|ROS1	glioblastoma|NSCLC								13	83					0	0	0	0
C6orf97	80129	broad.mit.edu	37	6	151936765	151936765	+	Missense_Mutation	SNP	T	T	C			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr6:151936765T>C	uc003qol.2	+	10	1987	c.1898T>C	c.(1897-1899)ATG>ACG	p.M633T		NM_025059	NP_079335	Q8IYT3	CF097_HUMAN	hypothetical protein LOC80129	633	Potential.										0		Ovarian(120;0.126)	BRCA - Breast invasive adenocarcinoma(37;0.111)	OV - Ovarian serous cystadenocarcinoma(155;1.48e-10)		ACCAGTGAAATGAAGACACTA	0.398		NA											38	45					0	0	0	0
FAM188B	84182	broad.mit.edu	37	7	30818091	30818091	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr7:30818091G>A	uc003tbt.2	+	2	184	c.107G>A	c.(106-108)CGC>CAC	p.R36H	FAM188B_uc010kwe.2_Missense_Mutation_p.R7H	NM_032222	NP_115598	Q4G0A6	F188B_HUMAN	hypothetical protein LOC84182	36											0						GAACGCCCACGCTCTGACCTC	0.438		NA											15	62					0	0	0	0
VPS41	27072	broad.mit.edu	37	7	38781699	38781699	+	Missense_Mutation	SNP	G	G	T			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr7:38781699G>T	uc003tgy.2	-	25	2171	c.2145C>A	c.(2143-2145)AAC>AAA	p.N715K	VPS41_uc003tgz.2_Missense_Mutation_p.N690K|VPS41_uc010kxn.2_Missense_Mutation_p.N626K|VPS41_uc003tgx.2_RNA	NM_014396	NP_055211	P49754	VPS41_HUMAN	vacuolar protein sorting 41 isoform 1	715					Golgi vesicle transport|intracellular protein transport|vesicle-mediated transport	cytosol|Golgi-associated vesicle|HOPS complex|membrane fraction	zinc ion binding			skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	4						TGCCAATGTTGTTTAACAAGC	0.323		NA											6	27					0.000274275	0.000290992	1	0
PKD1L1	168507	broad.mit.edu	37	7	47882701	47882701	+	Silent	SNP	G	G	T			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr7:47882701G>T	uc003tny.1	-	34	5304	c.5304C>A	c.(5302-5304)GTC>GTA	p.V1768V		NM_138295	NP_612152	Q8TDX9	PK1L1_HUMAN	polycystin-1L1	1768	Helical; (Potential).				cell-cell adhesion	integral to membrane				ovary(8)|upper_aerodigestive_tract(2)|breast(1)	11						TACTTTTAGCGACCAAAAATC	0.388		NA											10	21					2.18e-05	2.37e-05	1	0
SEMA3A	10371	broad.mit.edu	37	7	83610760	83610760	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr7:83610760G>A	uc003uhz.2	-	14	1844	c.1529C>T	c.(1528-1530)GCC>GTC	p.A510V		NM_006080	NP_006071	Q14563	SEM3A_HUMAN	semaphorin 3A precursor	510	Sema.				axon guidance	extracellular region|membrane	receptor activity			ovary(2)|breast(1)|kidney(1)	4						AGGGAGCTGGGCAACCCCAGC	0.453		NA											6	25					0	0	0	0
FZD1	8321	broad.mit.edu	37	7	90895581	90895581	+	Silent	SNP	C	C	T	rs150597135		TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr7:90895581C>T	uc003ula.2	+	1	1799	c.1386C>T	c.(1384-1386)ATC>ATT	p.I462I		NM_003505	NP_003496	Q9UP38	FZD1_HUMAN	frizzled 1 precursor	462	Helical; Name=4; (Potential).				autocrine signaling|axonogenesis|brain development|canonical Wnt receptor signaling pathway involved in mesenchymal stem cell differentiation|canonical Wnt receptor signaling pathway involved in osteoblast differentiation|embryo development|epithelial cell differentiation|G-protein signaling, coupled to cGMP nucleotide second messenger|gonad development|lung alveolus development|negative regulation of BMP signaling pathway|negative regulation of canonical Wnt receptor signaling pathway|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|response to drug|vasculature development|Wnt receptor signaling pathway, calcium modulating pathway	apical part of cell|cell surface|cytoplasm|integral to membrane|neuron projection membrane	G-protein coupled receptor activity|PDZ domain binding|receptor binding|Wnt receptor activity|Wnt-protein binding				0	all_cancers(62;3.1e-10)|all_epithelial(64;1.66e-08)|Breast(17;0.000635)|Lung NSC(181;0.153)|all_lung(186;0.154)|all_hematologic(106;0.215)		STAD - Stomach adenocarcinoma(171;0.0134)			CCATCACCATCCTGGCGCTGG	0.647		NA											27	86					0	0	0	0
AKAP9	10142	broad.mit.edu	37	7	91632007	91632007	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr7:91632007G>C	uc003ulg.2	+	8	3001	c.2776G>C	c.(2776-2778)GAA>CAA	p.E926Q	AKAP9_uc003ule.2_Missense_Mutation_p.E938Q|AKAP9_uc003ulf.2_Missense_Mutation_p.E926Q|AKAP9_uc003uli.2_Missense_Mutation_p.E551Q	NM_005751	NP_005742	Q99996	AKAP9_HUMAN	A-kinase anchor protein 9 isoform 2	938	Glu-rich.				G2/M transition of mitotic cell cycle|signal transduction|synaptic transmission|transport	centrosome|cytosol|Golgi apparatus	receptor binding			breast(7)|ovary(6)|lung(5)|skin(3)|large_intestine(2)|prostate(2)|central_nervous_system(1)	26	all_cancers(62;2.46e-09)|all_epithelial(64;4.42e-08)|Breast(17;0.00206)|all_lung(186;0.185)|all_hematologic(106;0.215)|Lung NSC(181;0.249)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)			TTTTGTAGCAGAAACATTGGA	0.358		NA	T	BRAF	papillary thyroid								9	38					0	0	0	0
PEX1	5189	broad.mit.edu	37	7	92147568	92147568	+	Missense_Mutation	SNP	T	T	C			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr7:92147568T>C	uc003uly.2	-	4	455	c.359A>G	c.(358-360)GAG>GGG	p.E120G	PEX1_uc011khr.1_5'UTR|PEX1_uc010ley.2_Missense_Mutation_p.E120G|PEX1_uc011khs.1_Intron|PEX1_uc011kht.1_5'Flank	NM_000466	NP_000457	O43933	PEX1_HUMAN	peroxin1	120					microtubule-based peroxisome localization|protein import into peroxisome matrix	cytosol|nucleus|peroxisomal membrane	ATP binding|ATPase activity, coupled|protein C-terminus binding|protein complex binding			ovary(1)|central_nervous_system(1)	2	all_cancers(62;9.35e-11)|all_epithelial(64;4.59e-10)|Breast(17;0.00201)|all_lung(186;0.0438)|Lung NSC(181;0.0592)	Breast(660;0.000932)|all_neural(109;0.00391)|Myeloproliferative disorder(862;0.0122)|Ovarian(593;0.023)|Medulloblastoma(109;0.123)	GBM - Glioblastoma multiforme(5;4.06e-06)|STAD - Stomach adenocarcinoma(4;4.51e-05)|all cancers(6;5.32e-05)|LUSC - Lung squamous cell carcinoma(200;0.225)|Lung(22;0.23)			AGCATGCAGCTCCTAGAACCA	0.303		NA											24	36					0	0	0	0
SGCE	8910	broad.mit.edu	37	7	94257653	94257653	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr7:94257653G>A	uc003unl.2	-	3	362	c.251C>T	c.(250-252)CCC>CTC	p.P84L	SGCE_uc003unm.2_Missense_Mutation_p.P84L|SGCE_uc003unn.2_Missense_Mutation_p.P84L|SGCE_uc011kic.1_Missense_Mutation_p.P43L|SGCE_uc011kid.1_Missense_Mutation_p.P120L	NM_003919	NP_003910	O43556	SGCE_HUMAN	sarcoglycan, epsilon isoform 2	84	Extracellular (Potential).				cell-matrix adhesion|muscle organ development	cytoplasm|cytoskeleton|integral to plasma membrane|sarcoglycan complex|sarcolemma	calcium ion binding			ovary(1)	1	all_cancers(62;8.26e-10)|all_epithelial(64;5.59e-09)|Lung NSC(181;0.188)|all_lung(186;0.215)		STAD - Stomach adenocarcinoma(171;0.0031)			AAATGTTATGGGATCATTACT	0.368		NA											13	22					0	0	0	0
BRAF	673	broad.mit.edu	37	7	140501295	140501295	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr7:140501295G>C	uc003vwc.3	-	6	838	c.777C>G	c.(775-777)TTC>TTG	p.F259L		NM_004333	NP_004324	P15056	BRAF_HUMAN	B-Raf	259	Phorbol-ester/DAG-type.				activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding		KIAA1549/BRAF(229)|AKAP9_ENST00000356239/BRAF(10)|AGTRAP/BRAF(2)|FCHSD1/BRAF(2)|SLC45A3/BRAF(2)	thyroid(8166)|large_intestine(5052)|skin(3798)|NS(368)|central_nervous_system(284)|ovary(236)|lung(78)|eye(53)|prostate(44)|endometrium(30)|biliary_tract(28)|soft_tissue(27)|haematopoietic_and_lymphoid_tissue(22)|breast(18)|upper_aerodigestive_tract(13)|stomach(13)|pancreas(10)|small_intestine(10)|testis(7)|bone(6)|cervix(5)|genital_tract(4)|oesophagus(3)|urinary_tract(3)|adrenal_gland(3)|gastrointestinal_tract_(site_indeterminate)(2)|liver(2)|meninges(1)|kidney(1)|autonomic_ganglia(1)|pituitary(1)|salivary_gland(1)	18290	Melanoma(164;0.00956)				Sorafenib(DB00398)	TTTGACAGCGGAAACCCTGGA	0.358		61	Mis|T|O	AKAP9|KIAA1549	melanoma|colorectal|papillary thyroid|borderline ov|Non small-cell lung cancer (NSCLC)|cholangiocarcinoma|pilocytic astrocytoma		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous_syndrome				5	31					0	0	0	0
CHPF2	54480	broad.mit.edu	37	7	150935153	150935153	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr7:150935153G>C	uc003wjr.1	+	4	3218	c.1705G>C	c.(1705-1707)GAG>CAG	p.E569Q	CHPF2_uc003wjq.1_Missense_Mutation_p.E561Q|MIR671_hsa-mir-671|MI0003760_5'Flank	NM_019015	NP_061888	Q9P2E5	CHPF2_HUMAN	chondroitin polymerizing factor 2	569	Lumenal (Potential).					Golgi cisterna membrane|integral to membrane	N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity			ovary(1)	1						TGTGCGAGCAGAGGCCCCTTC	0.632		NA											6	43					0	0	0	0
GALNT11	63917	broad.mit.edu	37	7	151798008	151798008	+	Splice_Site	SNP	T	T	C			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr7:151798008T>C	uc010lqg.1	+	3	649	c.419_splice	c.e3+2	p.A140_splice	GALNT11_uc011kvm.1_Splice_Site_p.A59_splice|GALNT11_uc003wku.2_Splice_Site_p.A140_splice|GALNT11_uc003wkv.1_Splice_Site_p.A140_splice|GALNT11_uc011kvn.1_Intron	NM_022087	NP_071370	Q8NCW6	GLT11_HUMAN	N-acetylgalactosaminyltransferase 11							Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding				0	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.214)	OV - Ovarian serous cystadenocarcinoma(82;0.00168)	UCEC - Uterine corpus endometrioid carcinoma (81;0.177)|BRCA - Breast invasive adenocarcinoma(188;0.0932)		GAATGCAGCGTATGTGCCTTA	0.448		NA											3	123					0	0	0	0
CSGALNACT1	55790	broad.mit.edu	37	8	19315939	19315939	+	Silent	SNP	G	G	A			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr8:19315939G>A	uc011kyn.1	-	5	1913	c.849C>T	c.(847-849)TTC>TTT	p.F283F	CSGALNACT1_uc011kyo.1_Silent_p.F283F|CSGALNACT1_uc003wzg.2_RNA|CSGALNACT1_uc011kyp.1_Silent_p.F282F|CSGALNACT1_uc003wzh.2_RNA	NM_001130518	NP_001123990	Q8TDX6	CGAT1_HUMAN	chondroitin sulfate	283	Lumenal (Potential).				anatomical structure morphogenesis|cell proliferation|cell recognition|chondroitin sulfate biosynthetic process|chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process|dermatan sulfate proteoglycan biosynthetic process|extracellular matrix organization|heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process|heparin biosynthetic process|nervous system development|UDP-glucuronate metabolic process|UDP-N-acetylgalactosamine metabolic process	Golgi cisterna membrane|integral to Golgi membrane|soluble fraction	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity|glucuronosyltransferase activity|glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity|metal ion binding|peptidoglycan glycosyltransferase activity			central_nervous_system(2)|ovary(1)	3				Colorectal(111;0.182)		AAACCAACCTGAAATTCTGCA	0.443		NA											46	141					0	0	0	0
HR	55806	broad.mit.edu	37	8	21973860	21973860	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr8:21973860G>A	uc003xas.2	-	18	4125	c.3460C>T	c.(3460-3462)CAC>TAC	p.H1154Y	HR_uc003xat.2_Missense_Mutation_p.H1099Y	NM_005144	NP_005135	O43593	HAIR_HUMAN	hairless protein isoform a	1154	JmjC.						DNA binding|metal ion binding|sequence-specific DNA binding transcription factor activity			large_intestine(1)|ovary(1)	2		Breast(100;0.000162)|Acute lymphoblastic leukemia(644;0.0775)|Prostate(55;0.116)		KIRC - Kidney renal clear cell carcinoma(542;1.19e-05)|BRCA - Breast invasive adenocarcinoma(99;3.56e-05)|Colorectal(74;0.00191)|COAD - Colon adenocarcinoma(73;0.0615)|READ - Rectum adenocarcinoma(644;0.1)		GGTCCCTGGTGGCAGAGCTGA	0.647		NA											11	13					0	0	0	0
NEFL	4747	broad.mit.edu	37	8	24813613	24813613	+	Nonsense_Mutation	SNP	G	G	C			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr8:24813613G>C	uc003xee.2	-	1	519	c.417C>G	c.(415-417)TAC>TAG	p.Y139*		NM_006158	NP_006149	P07196	NFL_HUMAN	neurofilament, light polypeptide 68kDa	139	Rod.|Coil 1B.				anterograde axon cargo transport|axon transport of mitochondrion|neurofilament bundle assembly|retrograde axon cargo transport|synaptic transmission	cytosol|neurofilament	identical protein binding|protein C-terminus binding|structural constituent of cytoskeleton			ovary(1)|central_nervous_system(1)	2		Ovarian(32;0.00965)|Prostate(55;0.157)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0197)|Epithelial(17;2.44e-10)|Colorectal(74;0.0108)|COAD - Colon adenocarcinoma(73;0.0375)		TCTCCTGCTCGTACAGCGCCC	0.682		NA											4	11					0	0	0	0
ZFHX4	79776	broad.mit.edu	37	8	77616773	77616773	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr8:77616773G>C	uc003yav.2	+	2	837	c.450G>C	c.(448-450)CAG>CAC	p.Q150H	ZFHX4_uc003yat.1_Missense_Mutation_p.Q150H|ZFHX4_uc003yau.1_Missense_Mutation_p.Q150H|ZFHX4_uc003yaw.1_Missense_Mutation_p.Q150H	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	150						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			AAAGTGGGCAGAATGCACAGA	0.488		NA								HNSCC(33;0.089)			27	21					0	0	0	0
TMEM64	169200	broad.mit.edu	37	8	91643854	91643854	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr8:91643854C>T	uc003yen.2	-	2	877	c.877G>A	c.(877-879)GGT>AGT	p.G293S	TMEM64_uc003yeo.2_Missense_Mutation_p.G32S|TMEM64_uc011lgf.1_Intron	NM_001008495	NP_001008495	Q6YI46	TMM64_HUMAN	transmembrane protein 64 isoform 1	293						integral to membrane					0			BRCA - Breast invasive adenocarcinoma(11;0.0598)			AGGGTGGTACCCAAGTAAGAA	0.423		NA											106	51					0	0	0	0
KIAA1429	25962	broad.mit.edu	37	8	95507153	95507153	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr8:95507153C>T	uc003ygo.1	-	20	4589	c.4576G>A	c.(4576-4578)GAT>AAT	p.D1526N	KIAA1429_uc010maz.1_RNA	NM_015496	NP_056311	Q69YN4	VIR_HUMAN	hypothetical protein LOC25962 isoform 1	1526					mRNA processing|RNA splicing	nucleus				ovary(1)|skin(1)	2	Breast(36;3.29e-05)		BRCA - Breast invasive adenocarcinoma(8;0.00185)			TTCAACTGATCATCCATGACA	0.308		NA											6	291					0	0	0	0
KCNV1	27012	broad.mit.edu	37	8	110984685	110984685	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr8:110984685G>A	uc003ynr.3	-	2	1135	c.793C>T	c.(793-795)CGG>TGG	p.R265W	KCNV1_uc010mcw.2_Missense_Mutation_p.R265W	NM_014379	NP_055194	Q6PIU1	KCNV1_HUMAN	potassium channel, subfamily V, member 1	265	Cytoplasmic (Potential).					voltage-gated potassium channel complex	ion channel inhibitor activity|potassium channel regulator activity|voltage-gated potassium channel activity			lung(1)|kidney(1)	2	all_neural(195;0.219)		OV - Ovarian serous cystadenocarcinoma(57;5.35e-13)			CACCTGTCCCGCACACACAGG	0.532		NA											38	46					0	0	0	0
PTK2	5747	broad.mit.edu	37	8	141874416	141874416	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr8:141874416G>A	uc003yvu.2	-	5	675	c.445C>T	c.(445-447)CAA>TAA	p.Q149*	PTK2_uc003yvr.2_Nonsense_Mutation_p.Q48*|PTK2_uc003yvs.2_Nonsense_Mutation_p.Q149*|PTK2_uc003yvt.2_Nonsense_Mutation_p.Q171*|PTK2_uc003yvv.2_Nonsense_Mutation_p.Q36*|PTK2_uc011ljr.1_Nonsense_Mutation_p.Q149*	NM_153831	NP_722560	Q05397	FAK1_HUMAN	PTK2 protein tyrosine kinase 2 isoform a	149	FERM.				axon guidance|blood coagulation|cellular component disassembly involved in apoptosis|ephrin receptor signaling pathway|growth hormone receptor signaling pathway|integrin-mediated signaling pathway|peptidyl-tyrosine phosphorylation|protein autophosphorylation|regulation of cell adhesion mediated by integrin|signal complex assembly	cytoskeleton|cytosol|focal adhesion	ATP binding|JUN kinase binding|non-membrane spanning protein tyrosine kinase activity|SH2 domain binding|signal transducer activity			ovary(2)|lung(2)|central_nervous_system(1)|skin(1)	6	all_cancers(97;1.05e-15)|all_epithelial(106;2.09e-14)|Lung NSC(106;1.61e-06)|all_lung(105;2.5e-06)|Ovarian(258;0.01)|Acute lymphoblastic leukemia(118;0.155)	Ovarian(118;2.72e-05)|Breast(495;0.159)	BRCA - Breast invasive adenocarcinoma(115;0.137)			AATACCTGTTGATAGAAGAAA	0.264		NA											11	134					0	0	0	0
KIAA1432	57589	broad.mit.edu	37	9	5763345	5763345	+	Missense_Mutation	SNP	A	A	G			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr9:5763345A>G	uc003zji.2	+	18	2174	c.2081A>G	c.(2080-2082)CAC>CGC	p.H694R	KIAA1432_uc003zjh.2_Missense_Mutation_p.H694R|KIAA1432_uc003zjl.3_Missense_Mutation_p.H657R|KIAA1432_uc003zjj.1_Missense_Mutation_p.H236R	NM_020829	NP_065880	Q4ADV7	RIC1_HUMAN	connexin 43-interacting protein 150 isoform a	773						integral to membrane					0		Acute lymphoblastic leukemia(23;0.154)		GBM - Glioblastoma multiforme(50;0.000525)|Lung(218;0.122)		CTGCCTTTCCACATCAACATT	0.478		NA											41	67					0	0	0	0
KIAA1432	57589	broad.mit.edu	37	9	5763371	5763371	+	Missense_Mutation	SNP	C	C	A			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr9:5763371C>A	uc003zji.2	+	18	2200	c.2107C>A	c.(2107-2109)CTG>ATG	p.L703M	KIAA1432_uc003zjh.2_Missense_Mutation_p.L703M|KIAA1432_uc003zjl.3_Missense_Mutation_p.L666M|KIAA1432_uc003zjj.1_Missense_Mutation_p.L245M	NM_020829	NP_065880	Q4ADV7	RIC1_HUMAN	connexin 43-interacting protein 150 isoform a	782						integral to membrane					0		Acute lymphoblastic leukemia(23;0.154)		GBM - Glioblastoma multiforme(50;0.000525)|Lung(218;0.122)		GCTAGCTGTTCTGTTTGAAGA	0.478		NA											47	82					1.33e-27	1.57e-27	1	0
KIAA1432	57589	broad.mit.edu	37	9	5765734	5765734	+	Missense_Mutation	SNP	G	G	T			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr9:5765734G>T	uc003zji.2	+	20	2929	c.2836G>T	c.(2836-2838)GTT>TTT	p.V946F	KIAA1432_uc003zjh.2_Missense_Mutation_p.V946F|KIAA1432_uc003zjl.3_Missense_Mutation_p.V909F|KIAA1432_uc003zjj.1_Missense_Mutation_p.V488F|ERMP1_uc011lme.1_RNA	NM_020829	NP_065880	Q4ADV7	RIC1_HUMAN	connexin 43-interacting protein 150 isoform a	1025						integral to membrane					0		Acute lymphoblastic leukemia(23;0.154)		GBM - Glioblastoma multiforme(50;0.000525)|Lung(218;0.122)		AGCTGAAAATGTTCCTGCCAG	0.408		NA											6	48					1.26e-09	1.43e-09	1	0
ZNF462	58499	broad.mit.edu	37	9	109688481	109688481	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr9:109688481G>C	uc004bcz.2	+	3	2577	c.2288G>C	c.(2287-2289)AGA>ACA	p.R763T	ZNF462_uc010mto.2_Missense_Mutation_p.R611T|ZNF462_uc004bda.2_Missense_Mutation_p.R611T	NM_021224	NP_067047	Q96JM2	ZN462_HUMAN	zinc finger protein 462	763					transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(5)	5						ATATGGGTAAGAGATACCAGT	0.488		NA											7	30					0	0	0	0
HDHD3	81932	broad.mit.edu	37	9	116136274	116136274	+	Silent	SNP	G	G	A			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr9:116136274G>A	uc004bhi.1	-	2	1145	c.361C>T	c.(361-363)CTG>TTG	p.L121L	HDHD3_uc004bhj.2_Silent_p.L121L|HDHD3_uc004bhk.2_Silent_p.L121L	NM_031219	NP_112496	Q9BSH5	HDHD3_HUMAN	haloacid dehalogenase-like hydrolase domain	121							phosphoglycolate phosphatase activity|protein binding				0						CACTCCCTCAGGGTGTCCTCA	0.602		NA											27	102					0	0	0	0
TNFSF8	944	broad.mit.edu	37	9	117666585	117666585	+	Missense_Mutation	SNP	T	T	C			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr9:117666585T>C	uc004bji.1	-	4	518	c.331A>G	c.(331-333)ACC>GCC	p.T111A		NM_001244	NP_001235	P32971	TNFL8_HUMAN	tumor necrosis factor (ligand) superfamily,	111	Extracellular (Potential).				cell proliferation|cell-cell signaling|immune response|induction of apoptosis|signal transduction	extracellular space|integral to plasma membrane	cytokine activity|tumor necrosis factor receptor binding			lung(3)|skin(2)|ovary(1)	6						GACAACTTGGTTTTGTTTAGA	0.378		NA											48	46					0	0	0	0
STRBP	55342	broad.mit.edu	37	9	125909210	125909210	+	Missense_Mutation	SNP	G	G	T			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr9:125909210G>T	uc004bns.2	-	13	1692	c.1262C>A	c.(1261-1263)TCT>TAT	p.S421Y	STRBP_uc004bnt.2_Missense_Mutation_p.S239Y|STRBP_uc004bnu.2_Missense_Mutation_p.S407Y|STRBP_uc004bnv.2_Missense_Mutation_p.S421Y|STRBP_uc004bnr.2_Missense_Mutation_p.S33Y	NM_018387	NP_060857	Q96SI9	STRBP_HUMAN	spermatid perinuclear RNA binding protein	421	DRBM 1.				multicellular organismal development	cytoplasm|nucleus	DNA binding			breast(1)|skin(1)	2						CACATCTACAGACATTGTGAA	0.453		NA											27	56					2.66e-16	3.12e-16	1	0
LRRC8A	56262	broad.mit.edu	37	9	131669481	131669481	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr9:131669481C>T	uc004bwl.3	+	3	292	c.38C>T	c.(37-39)ACG>ATG	p.T13M	LRRC8A_uc010myp.2_Missense_Mutation_p.T13M|LRRC8A_uc010myq.2_Missense_Mutation_p.T13M	NM_019594	NP_062540	Q8IWT6	LRC8A_HUMAN	leucine rich repeat containing 8 family, member	13					pre-B cell differentiation	integral to membrane					0						TTTGCGGACACGCAGCCAGCA	0.567		NA											9	20					0	0	0	0
PHKA2	5256	broad.mit.edu	37	X	18912411	18912411	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chrX:18912411G>A	uc004cyv.3	-	32	3878	c.3448C>T	c.(3448-3450)CTC>TTC	p.L1150F	uc004cyt.2_RNA|PHKA2_uc004cyu.3_Missense_Mutation_p.L456F|PHKA2_uc010nfe.1_Missense_Mutation_p.L182F|PHKA2_uc010nff.1_RNA	NM_000292	NP_000283	P46019	KPB2_HUMAN	phosphorylase kinase, alpha 2 (liver)	1150					glucose metabolic process|glycogen catabolic process	cytosol|phosphorylase kinase complex|plasma membrane	calmodulin binding|glucan 1,4-alpha-glucosidase activity|phosphorylase kinase activity			ovary(1)|central_nervous_system(1)	2	Hepatocellular(33;0.183)					GTGTCCGAGAGCAGCGTCAGC	0.612		NA											28	12					0	0	0	0
TAF7L	54457	broad.mit.edu	37	X	100547854	100547854	+	Silent	SNP	G	G	A			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chrX:100547854G>A	uc004ehb.2	-	1	192	c.180C>T	c.(178-180)GAC>GAT	p.D60D	TAF7L_uc004ehc.1_5'Flank	NM_024885	NP_079161	Q5H9L4	TAF7L_HUMAN	TATA box binding protein-associated factor, RNA	60					cell differentiation|multicellular organismal development|regulation of transcription, DNA-dependent|spermatogenesis|transcription initiation from RNA polymerase II promoter	cytoplasm|transcription factor TFIID complex	binding			breast(1)	1						GAGTGTCCTCGTCGGCAGGAA	0.562		NA											7	175					0	0	0	0
ODZ1	10178	broad.mit.edu	37	X	123870838	123870838	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chrX:123870838C>G	uc004euj.2	-	4	809	c.745G>C	c.(745-747)GTC>CTC	p.V249L	ODZ1_uc011muj.1_Missense_Mutation_p.V249L|ODZ1_uc010nqy.2_Missense_Mutation_p.V249L	NM_014253	NP_055068	Q9UKZ4	TEN1_HUMAN	odz, odd Oz/ten-m homolog 1 isoform 3	249	Teneurin N-terminal.|Cytoplasmic (Potential).				immune response|negative regulation of cell proliferation|nervous system development|signal transduction	extracellular region	heparin binding			ovary(11)|breast(4)|large_intestine(2)|skin(2)|pancreas(2)|upper_aerodigestive_tract(1)|lung(1)	23						CTGTTCAGGACCCAGCTGTTA	0.502		NA											168	88					0	0	0	0
IGSF1	3547	broad.mit.edu	37	X	130409627	130409627	+	Missense_Mutation	SNP	G	G	T			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chrX:130409627G>T	uc004ewd.2	-	16	3247	c.3009C>A	c.(3007-3009)CAC>CAA	p.H1003Q	IGSF1_uc004ewe.3_Missense_Mutation_p.H997Q|IGSF1_uc004ewf.2_Missense_Mutation_p.H983Q	NM_001555	NP_001546	Q8N6C5	IGSF1_HUMAN	immunoglobulin superfamily, member 1 isoform 1	1003	Extracellular (Potential).|Ig-like C2-type 10.				regulation of transcription, DNA-dependent	extracellular region|integral to membrane	inhibin beta-A binding|inhibin beta-B binding			ovary(3)|lung(1)|central_nervous_system(1)	5						CTCCTTCTTTGTGCAGAATGT	0.527		NA											11	71					2.35e-11	2.69e-11	1	0
MAGEA11	4110	broad.mit.edu	37	X	148798058	148798058	+	Silent	SNP	T	T	C			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chrX:148798058T>C	uc004fdq.2	+	5	1014	c.912T>C	c.(910-912)TGT>TGC	p.C304C	HSFX2_uc004fdl.2_Intron|HSFX1_uc004fdm.2_Intron|MAGEA11_uc004fdr.2_Silent_p.C275C	NM_005366	NP_005357	P43364	MAGAB_HUMAN	melanoma antigen family A, 11 isoform a	304	MAGE.					cytoplasm|nucleus	protein binding			ovary(2)	2	Acute lymphoblastic leukemia(192;6.56e-05)|Colorectal(9;0.0662)					GCATACAGTGTAATGAGCAGA	0.502		NA											23	101					0	0	0	0
SPEN	23013	broad.mit.edu	37	1	16263993	16263994	+	Frame_Shift_Ins	INS	-	-	C	rs141820706	by1000genomes	TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr1:16263993_16263994insC	uc001axk.1	+	12	10566_10567	c.10362_10363insC	c.(10360-10365)AAACAGfs	p.K3454fs	SPEN_uc010obp.1_Frame_Shift_Ins_p.K3413fs	NM_015001	NP_055816	Q96T58	MINT_HUMAN	spen homolog, transcriptional regulator	3454_3455	Pro-rich.				interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|Notch signaling pathway	nucleus	nucleotide binding|protein binding|RNA binding			ovary(6)|breast(3)|lung(2)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	15		Colorectal(325;0.000258)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0185)|Colorectal(212;5.96e-07)|COAD - Colon adenocarcinoma(227;3.11e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000115)|Kidney(64;0.000212)|KIRC - Kidney renal clear cell carcinoma(64;0.003)|STAD - Stomach adenocarcinoma(313;0.013)|READ - Rectum adenocarcinoma(331;0.0681)		CTGCCCCAAAACAGCCGTTGTT	0.579		NA											7	86	---	---	---	---	NA	NA	NA	NA
CD58	965	broad.mit.edu	37	1	117087209	117087209	+	Frame_Shift_Del	DEL	A	A	-			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr1:117087209delA	uc001egm.2	-	2	209	c.88delT	c.(88-90)TCCfs	p.S30fs	CD58_uc001egn.2_RNA|CD58_uc010owy.1_Frame_Shift_Del_p.S30fs|CD58_uc001ego.1_RNA|CD58_uc001egp.3_Frame_Shift_Del_p.S30fs	NM_001779	NP_001770	P19256	LFA3_HUMAN	CD58 molecule isoform 1	30	Extracellular (Potential).				blood coagulation|cell-cell adhesion|leukocyte migration	anchored to membrane|integral to plasma membrane	protein binding				0	Lung SC(450;0.225)	all_cancers(81;0.000363)|all_lung(203;0.000118)|all_epithelial(167;0.000149)|Lung NSC(69;0.000577)		Lung(183;0.0086)|LUSC - Lung squamous cell carcinoma(189;0.0528)|Colorectal(144;0.0775)|all cancers(265;0.109)|Epithelial(280;0.118)|COAD - Colon adenocarcinoma(174;0.121)		ATTTGTTGGGAAAAACAGCTG	0.343		NA											14	12	---	---	---	---	NA	NA	NA	NA
PDE4DIP	9659	broad.mit.edu	37	1	144994620	144994623	+	Frame_Shift_Del	DEL	CATA	CATA	-	rs149688356	byFrequency	TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr1:144994620_144994623delCATA	uc001elw.3	-	1	400_403	c.109_112delTATG	c.(109-114)TATGAGfs	p.Y37fs	NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|PDE4DIP_uc001elk.1_Frame_Shift_Del_p.Y37fs|PDE4DIP_uc001ell.1_Frame_Shift_Del_p.Y40fs|PDE4DIP_uc001elm.3_Frame_Shift_Del_p.Y5fs|PDE4DIP_uc001eln.3_Frame_Shift_Del_p.Y103fs|PDE4DIP_uc001elo.2_Frame_Shift_Del_p.Y174fs|PDE4DIP_uc001elx.3_Frame_Shift_Del_p.Y103fs|PDE4DIP_uc001emc.1_Frame_Shift_Del_p.Y37fs|PDE4DIP_uc001emd.1_Frame_Shift_Del_p.Y37fs|PDE4DIP_uc001emg.1_Frame_Shift_Del_p.Y37fs|PDE4DIP_uc001emh.2_Frame_Shift_Del_p.Y174fs	NM_014644	NP_055459	Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein isoform	37_38					cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			ovary(4)|haematopoietic_and_lymphoid_tissue(1)	5				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		CGGCTGGCCTCATACTTCTGTTGC	0.608		NA	T	PDGFRB	MPD								9	156	---	---	---	---	NA	NA	NA	NA
NRL	4901	broad.mit.edu	37	14	24551828	24551829	+	In_Frame_Ins	INS	-	-	GGT			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr14:24551828_24551829insGGT	uc001wlo.2	-	2	360_361	c.229_230insACC	c.(229-231)ACC>AACCCC	p.77_77T>NP	NRL_uc001wlp.2_In_Frame_Ins_p.77_77T>NP|NRL_uc001wlq.2_In_Frame_Ins_p.77_77T>NP	NM_006177	NP_006168	P54845	NRL_HUMAN	neural retina leucine zipper	77					response to stimulus|transcription from RNA polymerase II promoter|visual perception	nucleus	leucine zipper domain binding|sequence-specific DNA binding				0				GBM - Glioblastoma multiforme(265;0.0181)		CTGCTGCAGGGTAGCCAGCCAG	0.658		NA											9	57	---	---	---	---	NA	NA	NA	NA
TP53	7157	broad.mit.edu	37	17	7579410	7579420	+	Frame_Shift_Del	DEL	GGGGCCAGGAG	GGGGCCAGGAG	-			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr17:7579410_7579420delGGGGCCAGGAG	uc002gim.2	-	4	461_471	c.267_277delCTCCTGGCCCC	c.(265-279)CCCTCCTGGCCCCTGfs	p.P89fs	TP53_uc002gig.1_Frame_Shift_Del_p.P89fs|TP53_uc002gih.2_Frame_Shift_Del_p.P89fs|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_5'Flank|TP53_uc010cng.1_5'Flank|TP53_uc002gii.1_5'Flank|TP53_uc010cnh.1_Frame_Shift_Del_p.P89fs|TP53_uc010cni.1_Frame_Shift_Del_p.P89fs|TP53_uc002gij.2_Frame_Shift_Del_p.P89fs|TP53_uc010cnj.1_5'Flank|TP53_uc002gin.2_Intron|TP53_uc002gio.2_Intron|TP53_uc010vug.1_Frame_Shift_Del_p.P50fs|TP53_uc010cnk.1_Frame_Shift_Del_p.P104fs	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	89_93	Interaction with WWOX.		L -> P (in a sporadic cancer; somatic mutation).|L -> M (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.W91*(11)|p.0?(7)|p.A76_S90del15(3)|p.G59fs*23(3)|p.P89S(3)|p.L93fs*30(2)|p.P85fs*58(1)|p.W91fs*57(1)|p.W91fs*13(1)|p.A88fs*52(1)|p.V73fs*9(1)|p.D48fs*55(1)|p.L93M(1)|p.P87fs*54(1)|p.P89L(1)|p.P92fs*57(1)|p.S33fs*23(1)|p.A86fs*33(1)|p.A86fs*32(1)|p.P13fs*18(1)|p.P89fs*60(1)|p.S90F(1)|p.P92A(1)|p.P92L(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GAAGATGACAGGGGCCAGGAGGGGGCTGGTG	0.626		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			23	52	---	---	---	---	NA	NA	NA	NA
ZNF155	7711	broad.mit.edu	37	19	44501449	44501450	+	Frame_Shift_Ins	INS	-	-	A			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr19:44501449_44501450insA	uc002oxy.1	+	5	1645_1646	c.1440_1441insA	c.(1438-1443)CAGAAAfs	p.Q480fs	ZNF155_uc002oxz.1_Frame_Shift_Ins_p.Q480fs|ZNF155_uc010xwt.1_Frame_Shift_Ins_p.Q491fs|uc010ejc.1_RNA	NM_003445	NP_003436	Q12901	ZN155_HUMAN	zinc finger protein 155	480_481						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			large_intestine(1)|ovary(1)	2		Prostate(69;0.0352)				TCCACTGCCAGAAAAAACCATT	0.455		NA											23	86	---	---	---	---	NA	NA	NA	NA
FHL2	2274	broad.mit.edu	37	2	105977793	105977794	+	Frame_Shift_Ins	INS	-	-	G			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr2:105977793_105977794insG	uc002tcu.2	-	6	1123_1124	c.786_787insC	c.(784-789)GGCTTCfs	p.G262fs	FHL2_uc002tdc.2_Frame_Shift_Ins_p.G148fs|FHL2_uc002tdd.2_Frame_Shift_Ins_p.G262fs|FHL2_uc002tct.2_Frame_Shift_Ins_p.G148fs|FHL2_uc002tcv.2_Frame_Shift_Ins_p.G262fs|FHL2_uc002tcw.2_Frame_Shift_Ins_p.G262fs|FHL2_uc002tcx.2_Frame_Shift_Ins_p.G262fs|FHL2_uc010fje.2_Frame_Shift_Ins_p.G175fs|FHL2_uc002tcy.2_Frame_Shift_Ins_p.G262fs|FHL2_uc002tcz.2_Frame_Shift_Ins_p.G372fs|FHL2_uc002tda.2_RNA|FHL2_uc002tdb.2_Frame_Shift_Ins_p.G378fs	NM_201557	NP_963851	Q14192	FHL2_HUMAN	four and a half LIM domains 2	262_263	LIM zinc-binding 4.				androgen receptor signaling pathway|cellular lipid metabolic process|positive regulation of transcription, DNA-dependent|response to hormone stimulus|transcription, DNA-dependent	actin cytoskeleton|focal adhesion|nucleus	androgen receptor binding|identical protein binding|transcription coactivator activity|zinc ion binding			ovary(1)	1						TCTGTGAGGAAGCCACGCCCCA	0.5		NA											30	64	---	---	---	---	NA	NA	NA	NA
WHSC1	7468	broad.mit.edu	37	4	1957868	1957869	+	Frame_Shift_Ins	INS	-	-	C			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr4:1957868_1957869insC	uc003gdz.3	+	15	3010_3011	c.2834_2835insC	c.(2833-2835)GGCfs	p.G945fs	WHSC1_uc003geb.3_Frame_Shift_Ins_p.G945fs|WHSC1_uc003gec.3_Frame_Shift_Ins_p.G945fs|WHSC1_uc003ged.3_Frame_Shift_Ins_p.G945fs|WHSC1_uc003gee.3_RNA|WHSC1_uc003gef.3_RNA|WHSC1_uc003gei.3_Frame_Shift_Ins_p.G164fs|WHSC1_uc011bvh.1_Frame_Shift_Ins_p.G6fs|WHSC1_uc010icf.2_Frame_Shift_Ins_p.G293fs	NM_001042424	NP_001035889	O96028	NSD2_HUMAN	Wolf-Hirschhorn syndrome candidate 1 protein	945					anatomical structure morphogenesis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|cytoplasm|nuclear membrane|nucleolus	DNA binding|histone-lysine N-methyltransferase activity|zinc ion binding			ovary(3)|lung(3)|skin(2)|pancreas(1)	9		all_epithelial(65;1.34e-05)	OV - Ovarian serous cystadenocarcinoma(23;0.00606)	STAD - Stomach adenocarcinoma(129;0.232)		GGGGACCGGGGCAGCCGCTACC	0.51		NA	T	IGH@	MM								30	214	---	---	---	---	NA	NA	NA	NA
FBXO30	84085	broad.mit.edu	37	6	146126707	146126708	+	Frame_Shift_Ins	INS	-	-	A			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr6:146126707_146126708insA	uc003qla.2	-	2	1033_1034	c.834_835insT	c.(832-837)TATGACfs	p.Y278fs	uc003qky.1_Intron	NM_032145	NP_115521	Q8TB52	FBX30_HUMAN	F-box only protein 30	278_279							ubiquitin-protein ligase activity|zinc ion binding			ovary(2)|large_intestine(1)	3		Ovarian(120;0.0776)		OV - Ovarian serous cystadenocarcinoma(155;1.95e-07)|GBM - Glioblastoma multiforme(68;0.0149)		GCAGAAGTGTCATAAGAACTTG	0.356		NA											40	111	---	---	---	---	NA	NA	NA	NA
ERLIN2	11160	broad.mit.edu	37	8	37595472	37595473	+	Frame_Shift_Ins	INS	-	-	T			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr8:37595472_37595473insT	uc003xke.3	+	2	147_148	c.32_33insT	c.(31-33)GCTfs	p.A11fs	uc003xkb.1_5'Flank|ERLIN2_uc003xkc.3_Frame_Shift_Ins_p.A11fs|ERLIN2_uc003xkd.2_Frame_Shift_Ins_p.A11fs|ERLIN2_uc003xkf.3_Frame_Shift_Ins_p.A11fs|ERLIN2_uc003xkg.2_Frame_Shift_Ins_p.A11fs	NM_007175	NP_009106	O94905	ERLN2_HUMAN	ER lipid raft associated 2 isoform 1	11	Helical; (Potential).				ER-associated protein catabolic process	endoplasmic reticulum membrane|integral to membrane|plasma membrane	protein binding				0		Lung NSC(58;0.174)	BRCA - Breast invasive adenocarcinoma(5;6.14e-24)|LUSC - Lung squamous cell carcinoma(8;3.5e-10)			GTGGCTGTGGCTTCCAGTTTCT	0.5		NA											10	171	---	---	---	---	NA	NA	NA	NA
VPS13B	157680	broad.mit.edu	37	8	100479733	100479733	+	Frame_Shift_Del	DEL	G	G	-			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr8:100479733delG	uc003yiv.2	+	24	3648	c.3537delG	c.(3535-3537)ATGfs	p.M1179fs	VPS13B_uc003yiw.2_Frame_Shift_Del_p.M1179fs|VPS13B_uc003yiu.1_Frame_Shift_Del_p.M1179fs|VPS13B_uc003yix.1_Frame_Shift_Del_p.M649fs	NM_017890	NP_060360	Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13B isoform 5	1179					protein transport					ovary(7)|skin(4)|lung(3)|central_nervous_system(2)|pancreas(2)|breast(1)|kidney(1)	20	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			TGGAACCTATGGGTTGCACCT	0.443		NA											85	348	---	---	---	---	NA	NA	NA	NA
EPB41L4B	54566	broad.mit.edu	37	9	111945031	111945031	+	Frame_Shift_Del	DEL	A	A	-			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr9:111945031delA	uc004bdz.1	-	24	2760	c.2465delT	c.(2464-2466)TTCfs	p.F822fs		NM_019114	NP_061987	Q9H329	E41LB_HUMAN	erythrocyte membrane protein band 4.1 like 4B	822						cytoplasm|cytoskeleton|extrinsic to membrane	cytoskeletal protein binding|structural constituent of cytoskeleton			ovary(1)|central_nervous_system(1)|skin(1)	3						CCCTGTGGTGAAAGTATCAGG	0.418		NA											63	50	---	---	---	---	NA	NA	NA	NA
RBM10	8241	broad.mit.edu	37	X	47030561	47030563	+	In_Frame_Del	DEL	GGA	GGA	-			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chrX:47030561_47030563delGGA	uc004dhf.2	+	4	715_717	c.336_338delGGA	c.(334-339)GGGGAG>GGG	p.E119del	RBM10_uc004dhe.1_In_Frame_Del_p.E109del|RBM10_uc004dhg.2_Intron|RBM10_uc004dhh.2_In_Frame_Del_p.E119del|RBM10_uc010nhq.2_Intron|RBM10_uc004dhi.2_In_Frame_Del_p.E184del	NM_005676	NP_005667	P98175	RBM10_HUMAN	RNA binding motif protein 10 isoform 1	119	Poly-Glu.				mRNA processing|RNA splicing	chromatin remodeling complex	nucleotide binding|RNA binding|zinc ion binding			ovary(1)|large_intestine(1)|prostate(1)|breast(1)|pancreas(1)	5						CCGAGCAAGGggaggaggaggag	0.522		NA											10	128	---	---	---	---	NA	NA	NA	NA