Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	isArtifactMode	oxoGCut
PHF13	148479	broad.mit.edu	37	1	6680226	6680226	+	Missense_Mutation	SNP	T	T	G			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr1:6680226T>G	uc001aob.3	+	3	876	c.505T>G	c.(505-507)TCG>GCG	p.S169A		NM_153812	NP_722519	Q86YI8	PHF13_HUMAN	PHD finger protein 13	169					cell division|chromatin modification|mitotic chromosome condensation	nucleoplasm	chromatin binding|methylated histone residue binding|zinc ion binding				0	Ovarian(185;0.0212)|all_lung(157;0.154)	all_cancers(23;1.46e-33)|all_epithelial(116;9.26e-22)|all_lung(118;7.57e-07)|Lung NSC(185;4.26e-06)|Breast(487;0.000353)|Renal(390;0.0007)|Colorectal(325;0.00104)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0443)		Colorectal(212;1.19e-07)|COAD - Colon adenocarcinoma(227;1.3e-05)|Kidney(185;4.88e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000501)|KIRC - Kidney renal clear cell carcinoma(229;0.000871)|STAD - Stomach adenocarcinoma(132;0.0165)|READ - Rectum adenocarcinoma(331;0.0642)		CGACCCCTGCTCGGGCTGGGA	0.597		NA											16	31					0	0	0	0
RHD	6007	broad.mit.edu	37	1	25611200	25611200	+	Silent	SNP	C	C	T			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr1:25611200C>T	uc001bjz.2	+	2	343	c.285C>T	c.(283-285)GAC>GAT	p.D95D	RHD_uc010oep.1_Silent_p.D95D|RHD_uc001bkc.2_Silent_p.D95D|RHD_uc009vrm.2_Translation_Start_Site|RHD_uc001bka.2_Silent_p.D95D|RHD_uc001bkb.2_Silent_p.D95D|RHD_uc009vrn.2_Silent_p.D95D|RHD_uc009vro.2_Silent_p.D95D|RHD_uc009vrp.2_Silent_p.D95D	NM_016124	NP_057208	Q02161	RHD_HUMAN	Rh blood group D antigen isoform 1	95	Helical; (Potential).					integral to plasma membrane				breast(1)	1		Colorectal(325;3.46e-05)|Lung NSC(340;0.000245)|all_lung(284;0.000335)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0101)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0936)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0415)|OV - Ovarian serous cystadenocarcinoma(117;7.39e-27)|Colorectal(126;8.83e-09)|COAD - Colon adenocarcinoma(152;6.43e-07)|STAD - Stomach adenocarcinoma(196;0.000332)|BRCA - Breast invasive adenocarcinoma(304;0.000438)|KIRC - Kidney renal clear cell carcinoma(1967;0.000716)|GBM - Glioblastoma multiforme(114;0.000908)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.199)		TCCTGCTGGACGGCTTCCTGA	0.572		NA											5	53					0	0	0	0
DCDC2B	149069	broad.mit.edu	37	1	32677785	32677785	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr1:32677785G>C	uc001bun.2	+	4	510	c.510G>C	c.(508-510)CAG>CAC	p.Q170H		NM_001099434	NP_001092904	A2VCK2	DCD2B_HUMAN	doublecortin domain containing 2B	170	Doublecortin 2.				intracellular signal transduction						0		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Ovarian(437;0.101)|Breast(348;0.174)				TCAAGTTGCAGAGTGGGGCTG	0.577		NA											8	87					0	0	0	0
EIF2C1	26523	broad.mit.edu	37	1	36367908	36367909	+	Missense_Mutation	DNP	CC	CC	TA			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr1:36367908_36367909CC>TA	uc001bzl.2	+	11	1580_1581	c.1367_1368CC>TA	c.(1366-1368)CCC>CTA	p.P456L	EIF2C1_uc001bzk.2_Missense_Mutation_p.P381L|EIF2C1_uc009vuy.2_Intron	NM_012199	NP_036331	Q9UL18	AGO1_HUMAN	eukaryotic translation initiation factor 2C, 1	456					negative regulation of translation involved in gene silencing by miRNA|nuclear-transcribed mRNA catabolic process|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol|micro-ribonucleoprotein complex|polysome	protein binding|RNA binding			ovary(2)|skin(1)	3		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				TGCTTCGCACCCCAAAAACAGT	0.574		NA											20	53					0	0	0	0
HEYL	26508	broad.mit.edu	37	1	40092678	40092678	+	Missense_Mutation	SNP	G	G	A	rs139668981	byFrequency	TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr1:40092678G>A	uc001cdp.2	-	5	539	c.488C>T	c.(487-489)TCG>TTG	p.S163L	HEYL_uc010oiw.1_Missense_Mutation_p.S135L	NM_014571	NP_055386	Q9NQ87	HEYL_HUMAN	hairy/enhancer-of-split related with YRPW	163	Pro-rich.				multicellular organismal development|Notch signaling pathway|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(1)	1	Lung NSC(20;3.81e-06)|Ovarian(52;0.00769)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;1.1e-18)|Epithelial(16;2.77e-17)|all cancers(16;5.64e-16)|LUSC - Lung squamous cell carcinoma(16;0.000261)|Lung(16;0.000457)			GGGCGTGGGCGAAGGCTCCAT	0.652		NA											15	36					0	0	0	0
RLF	6018	broad.mit.edu	37	1	40701683	40701683	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr1:40701683G>C	uc001cfc.3	+	8	1340	c.1309G>C	c.(1309-1311)GAT>CAT	p.D437H	RLF_uc001cfd.3_Missense_Mutation_p.D128H	NM_012421	NP_036553	Q13129	RLF_HUMAN	rearranged L-myc fusion	437					chromosome organization|DNA integration|DNA mediated transformation|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			ovary(2)|pancreas(1)	3	Lung NSC(20;4.38e-06)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;5.87e-19)|Epithelial(16;7.02e-16)|all cancers(16;1.69e-14)|Lung(16;0.0427)|LUSC - Lung squamous cell carcinoma(16;0.0461)			TTTGCAACCAGATCAAAAATT	0.368		NA											23	111					0	0	0	0
AK5	26289	broad.mit.edu	37	1	77752661	77752661	+	Missense_Mutation	SNP	A	A	C			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr1:77752661A>C	uc001dhn.2	+	2	353	c.96A>C	c.(94-96)GAA>GAC	p.E32D	AK5_uc001dho.2_Missense_Mutation_p.E6D|AK5_uc001dhm.1_Missense_Mutation_p.E32D	NM_174858	NP_777283	Q9Y6K8	KAD5_HUMAN	adenylate kinase 5 isoform 1	32					ADP biosynthetic process|ATP metabolic process|dADP biosynthetic process|nucleobase, nucleoside and nucleotide interconversion|pyrimidine ribonucleotide biosynthetic process|signal transduction	centrosome|cytosol	adenylate kinase activity|ATP binding|cAMP-dependent protein kinase regulator activity|nucleoside kinase activity			skin(1)	1						CTAAGCCCGAAGATCCAGTAG	0.338		NA											34	44					0	0	0	0
SYDE2	84144	broad.mit.edu	37	1	85630216	85630216	+	Silent	SNP	G	G	A			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr1:85630216G>A	uc009wcm.2	-	6	3127	c.3078C>T	c.(3076-3078)CTC>CTT	p.L1026L		NM_032184	NP_115560	Q5VT97	SYDE2_HUMAN	synapse defective 1, Rho GTPase, homolog 2	1026	Rho-GAP.				activation of Rho GTPase activity|small GTPase mediated signal transduction	cytosol	Rho GTPase activator activity			ovary(1)|central_nervous_system(1)	2				all cancers(265;0.0126)|Epithelial(280;0.0336)		TACCTGGCCAGAGTTGGAGTA	0.318		NA											5	11					0	0	0	0
HFM1	164045	broad.mit.edu	37	1	91861862	91861862	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr1:91861862G>A	uc001doa.3	-	3	272	c.172C>T	c.(172-174)CAT>TAT	p.H58Y	HFM1_uc010osu.1_Intron|HFM1_uc010osv.1_Intron|HFM1_uc001doc.1_Missense_Mutation_p.H58Y	NM_001017975	NP_001017975	A2PYH4	HFM1_HUMAN	HFM1 protein	58							ATP binding|ATP-dependent helicase activity|nucleic acid binding				0		all_lung(203;0.00961)|Lung NSC(277;0.0351)		all cancers(265;0.000481)|Epithelial(280;0.00863)|OV - Ovarian serous cystadenocarcinoma(397;0.126)|KIRC - Kidney renal clear cell carcinoma(1967;0.171)		AACAGTTTATGACTTTCTAAT	0.303		NA											7	26					0	0	0	0
COL11A1	1301	broad.mit.edu	37	1	103480096	103480096	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr1:103480096G>A	uc001dul.2	-	13	1861	c.1543C>T	c.(1543-1545)CAG>TAG	p.Q515*	COL11A1_uc001duk.2_5'UTR|COL11A1_uc001dum.2_Nonsense_Mutation_p.Q527*|COL11A1_uc001dun.2_Nonsense_Mutation_p.Q476*|COL11A1_uc009weh.2_Nonsense_Mutation_p.Q399*	NM_001854	NP_001845	P12107	COBA1_HUMAN	alpha 1 type XI collagen isoform A	515	Telopeptide.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			ovary(6)|breast(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	12		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		GCTTGAGCCTGAGCTTCCTGA	0.418		NA											7	33					0	0	0	0
NTNG1	22854	broad.mit.edu	37	1	107691398	107691398	+	Silent	SNP	G	G	A			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr1:107691398G>A	uc001dvh.3	+	2	901	c.183G>A	c.(181-183)CTG>CTA	p.L61L	NTNG1_uc001dvf.3_Silent_p.L61L|NTNG1_uc010out.1_Silent_p.L61L|NTNG1_uc001dvc.3_Silent_p.L61L|NTNG1_uc001dvd.1_Silent_p.L61L	NM_001113226	NP_001106697	Q9Y2I2	NTNG1_HUMAN	netrin G1 isoform 1	61	Laminin N-terminal.				axonogenesis	anchored to plasma membrane	protein binding			large_intestine(2)|ovary(2)|skin(2)	6		all_epithelial(167;1.39e-05)|all_lung(203;0.000115)|Lung NSC(277;0.000238)|Breast(1374;0.243)		Lung(183;0.0946)|BRCA - Breast invasive adenocarcinoma(282;0.237)|Epithelial(280;0.245)		CAAAATATCTGAAAGTGAAAC	0.423		NA											21	96					0	0	0	0
GPR61	83873	broad.mit.edu	37	1	110086037	110086037	+	Silent	SNP	C	C	G			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr1:110086037C>G	uc001dxy.2	+	2	1076	c.393C>G	c.(391-393)CTC>CTG	p.L131L		NM_031936	NP_114142	Q9BZJ8	GPR61_HUMAN	G protein-coupled receptor 61	131	Helical; Name=3; (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			central_nervous_system(2)	2		all_epithelial(167;2.83e-05)|all_lung(203;0.00016)|Lung NSC(277;0.000318)|Breast(1374;0.244)		Lung(183;0.0426)|Colorectal(144;0.11)|Epithelial(280;0.128)|all cancers(265;0.132)|LUSC - Lung squamous cell carcinoma(189;0.228)		TGGCCATCCTCTCGGTGTCAG	0.607		NA											22	92					0	0	0	0
SPAG17	200162	broad.mit.edu	37	1	118693935	118693935	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr1:118693935G>C	uc001ehk.2	-	2	213	c.145C>G	c.(145-147)CTC>GTC	p.L49V		NM_206996	NP_996879	Q6Q759	SPG17_HUMAN	sperm associated antigen 17	49						cilium|flagellar axoneme|microtubule				upper_aerodigestive_tract(2)|ovary(2)|large_intestine(1)|skin(1)	6	Esophageal squamous(2;0.0106)	all_cancers(81;0.0204)|all_lung(203;9.46e-05)|Lung NSC(69;0.000675)|all_epithelial(167;0.01)		Lung(183;0.0858)		GCTTGGATGAGAAGATCATCT	0.453		NA											8	41					0	0	0	0
NBPF10	100132406	broad.mit.edu	37	1	145301812	145301812	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr1:145301812G>A	uc001end.3	+	7	1116	c.1081G>A	c.(1081-1083)GAG>AAG	p.E361K	NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|NBPF10_uc001emp.3_Missense_Mutation_p.E361K|NBPF10_uc010oyi.1_5'Flank|NBPF10_uc001emq.1_Missense_Mutation_p.E90K	NM_001039703	NP_001034792	A6NDV3	A6NDV3_HUMAN	hypothetical protein LOC100132406	361											0	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		CAAGCAAGCTGAGGAGCTCAG	0.522		NA											28	183					0	0	0	0
ITGA10	8515	broad.mit.edu	37	1	145536002	145536002	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr1:145536002G>C	uc001eoa.2	+	17	2170	c.2094G>C	c.(2092-2094)ATG>ATC	p.M698I	NBPF10_uc001emp.3_Intron|ITGA10_uc010oyv.1_Missense_Mutation_p.M567I|ITGA10_uc009wiw.2_Missense_Mutation_p.M555I|ITGA10_uc010oyw.1_Missense_Mutation_p.M643I	NM_003637	NP_003628	O75578	ITA10_HUMAN	integrin, alpha 10 precursor	698	Extracellular (Potential).				cell-matrix adhesion|integrin-mediated signaling pathway	integrin complex	collagen binding|receptor activity			lung(2)|ovary(2)|kidney(2)|large_intestine(1)|skin(1)	8	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					ATTCAGACATGAGGTTCACCG	0.542		NA											30	108					0	0	0	0
TUFT1	7286	broad.mit.edu	37	1	151552206	151552206	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr1:151552206G>C	uc001eyl.2	+	11	1068	c.1006G>C	c.(1006-1008)GAG>CAG	p.E336Q	TUFT1_uc001eym.2_Missense_Mutation_p.E311Q|TUFT1_uc010pdf.1_Missense_Mutation_p.E355Q|TUFT1_uc010pdg.1_Missense_Mutation_p.E284Q	NM_020127	NP_064512	Q9NNX1	TUFT1_HUMAN	tuftelin 1 isoform 1	336	Potential.				bone mineralization|odontogenesis	cytoplasm|extracellular region	structural constituent of tooth enamel				0	Ovarian(49;0.0273)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		LUSC - Lung squamous cell carcinoma(543;0.181)			TCTGGAGGCAGAGGTGTGTGT	0.532		NA											5	12					0	0	0	0
ADAR	103	broad.mit.edu	37	1	154573540	154573540	+	Silent	SNP	C	C	T			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr1:154573540C>T	uc001ffh.2	-	2	1778	c.1578G>A	c.(1576-1578)CAG>CAA	p.Q526Q	ADAR_uc001ffj.2_Silent_p.Q526Q|ADAR_uc001ffi.2_Silent_p.Q526Q|ADAR_uc001ffk.2_Silent_p.Q231Q|ADAR_uc001ffl.1_Silent_p.Q231Q	NM_001111	NP_001102	P55265	DSRAD_HUMAN	adenosine deaminase, RNA-specific isoform a	526	DRBM 1.				adenosine to inosine editing|gene silencing by RNA|mRNA modification|mRNA processing|type I interferon-mediated signaling pathway	cytoplasm|nucleolus|nucleoplasm	DNA binding|double-stranded RNA adenosine deaminase activity|metal ion binding			ovary(3)|breast(1)|central_nervous_system(1)|skin(1)	6	all_lung(78;2.22e-29)|Lung NSC(65;3.66e-27)|all_hematologic(923;0.088)|Hepatocellular(266;0.0997)		LUSC - Lung squamous cell carcinoma(543;0.185)	Colorectal(1306;0.115)		GTGGTCCACTCTGCTCTATCA	0.517		NA											18	97					0	0	0	0
TRIM46	80128	broad.mit.edu	37	1	155156625	155156625	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr1:155156625G>A	uc001fhs.1	+	10	2322	c.2239G>A	c.(2239-2241)GAG>AAG	p.E747K	RAG1AP1_uc010pey.1_Intron|TRIM46_uc001fht.1_RNA|TRIM46_uc010pfa.1_Missense_Mutation_p.E621K|TRIM46_uc001fhu.1_Missense_Mutation_p.E724K|TRIM46_uc001fhw.1_RNA	NM_025058	NP_079334	Q7Z4K8	TRI46_HUMAN	tripartite motif-containing 46	747	B30.2/SPRY.					intracellular	zinc ion binding			ovary(1)|central_nervous_system(1)|skin(1)	3	all_epithelial(22;5.72e-28)|all_lung(78;2.07e-24)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		Epithelial(20;6.62e-10)|all cancers(21;2.68e-09)|BRCA - Breast invasive adenocarcinoma(34;0.000752)|LUSC - Lung squamous cell carcinoma(543;0.193)			CACTAAGCCTGAGAGGAAAGT	0.642		NA											5	23					0	0	0	0
RAB25	57111	broad.mit.edu	37	1	156038115	156038115	+	Missense_Mutation	SNP	G	G	T			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr1:156038115G>T	uc001fnc.2	+	3	520	c.294G>T	c.(292-294)CAG>CAT	p.Q98H		NM_020387	NP_065120	P57735	RAB25_HUMAN	RAB25	98					positive regulation of cell proliferation|protein transport|pseudopodium organization|small GTPase mediated signal transduction	cytoplasmic membrane-bounded vesicle|pseudopodium membrane	GTP binding|identical protein binding				0	Hepatocellular(266;0.158)|all_neural(408;0.195)					CCAAGCACCAGACCTATGCTG	0.547		NA											68	77					9.56e-27	1.09e-26	1	0
CD1B	910	broad.mit.edu	37	1	158300658	158300658	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr1:158300658C>G	uc001frx.2	-	2	364	c.256G>C	c.(256-258)GAG>CAG	p.E86Q	CD1B_uc001frw.2_5'UTR|CD1B_uc010pic.1_Missense_Mutation_p.E86Q	NM_001764	NP_001755	P29016	CD1B_HUMAN	CD1B antigen precursor	86	Extracellular (Potential).				antigen processing and presentation|immune response	endosome membrane|integral to membrane|lysosomal membrane|plasma membrane	protein binding			ovary(2)	2	all_hematologic(112;0.0378)					CGGAATATCTCCTCTAACTCA	0.458		NA											79	311					0	0	0	0
OR6N1	128372	broad.mit.edu	37	1	158736156	158736156	+	Missense_Mutation	SNP	G	G	T			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr1:158736156G>T	uc010piq.1	-	1	317	c.317C>A	c.(316-318)TCC>TAC	p.S106Y		NM_001005185	NP_001005185	Q8NGY5	OR6N1_HUMAN	olfactory receptor, family 6, subfamily N,	106	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	all_hematologic(112;0.0378)					CGCTCCAAGGGAGTGAAAGAA	0.502		NA											12	34					5.51e-06	5.87e-06	1	0
GPR161	23432	broad.mit.edu	37	1	168059864	168059864	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr1:168059864C>T	uc001gfc.2	-	6	1456	c.1142G>A	c.(1141-1143)GGA>GAA	p.G381E	GPR161_uc001gfb.2_Missense_Mutation_p.G249E|GPR161_uc010pll.1_Missense_Mutation_p.G291E|GPR161_uc010plm.1_Missense_Mutation_p.G267E|GPR161_uc009wvo.2_Missense_Mutation_p.G398E|GPR161_uc001gfd.2_Missense_Mutation_p.G381E|GPR161_uc010pln.1_Missense_Mutation_p.G401E|GPR161_uc001gfe.1_Missense_Mutation_p.G381E	NM_153832	NP_722561	Q8N6U8	GP161_HUMAN	G protein-coupled receptor 161 isoform 2	381	Cytoplasmic (Potential).				multicellular organismal development	integral to membrane|plasma membrane	G-protein coupled receptor activity				0	all_hematologic(923;0.215)					CAGGGGCTGTCCACCTGCCAT	0.597		NA											6	13					0	0	0	0
TNN	63923	broad.mit.edu	37	1	175116116	175116116	+	Missense_Mutation	SNP	T	T	C			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr1:175116116T>C	uc001gkl.1	+	19	3922	c.3809T>C	c.(3808-3810)GTG>GCG	p.V1270A		NM_022093	NP_071376	Q9UQP3	TENN_HUMAN	tenascin N precursor	1270	Fibrinogen C-terminal.				cell growth|cell migration|signal transduction	extracellular space|proteinaceous extracellular matrix				large_intestine(5)|ovary(3)|central_nervous_system(1)	9		Breast(1374;0.000962)		KIRC - Kidney renal clear cell carcinoma(1967;0.00198)		ATTCCTTACGTGGAGTTGAAA	0.522		NA									OREG0013992	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	15	45					0	0	0	0
TDRD5	163589	broad.mit.edu	37	1	179561846	179561846	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr1:179561846G>C	uc001gnf.1	+	2	346	c.96G>C	c.(94-96)GAG>GAC	p.E32D	TDRD5_uc010pnp.1_Missense_Mutation_p.E32D|uc010pno.1_5'Flank	NM_173533	NP_775804	Q8NAT2	TDRD5_HUMAN	tudor domain containing 5	32	Lotus/OST-HTH 1.				DNA methylation involved in gamete generation|P granule organization|spermatid development	chromatoid body|pi-body	nucleic acid binding			ovary(2)|skin(2)|central_nervous_system(1)	5						AGGAGTTGGAGAAGGAGTACC	0.478		NA											23	106					0	0	0	0
ZNF281	23528	broad.mit.edu	37	1	200377873	200377873	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr1:200377873G>A	uc001gve.2	-	2	1068	c.961C>T	c.(961-963)CAG>TAG	p.Q321*	ZNF281_uc001gvf.1_Nonsense_Mutation_p.Q321*|ZNF281_uc001gvg.1_Nonsense_Mutation_p.Q285*	NM_012482	NP_036614	Q9Y2X9	ZN281_HUMAN	zinc finger protein 281	321	C2H2-type 3.				negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(1)|breast(1)	2						ATGCTGCACTGATCACATCCA	0.403		NA											117	171					0	0	0	0
LGR6	59352	broad.mit.edu	37	1	202287786	202287786	+	Silent	SNP	C	C	G			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr1:202287786C>G	uc001gxu.2	+	18	2355	c.2355C>G	c.(2353-2355)CTC>CTG	p.L785L	LGR6_uc001gxv.2_Silent_p.L733L|LGR6_uc009xab.2_RNA|LGR6_uc001gxw.2_Silent_p.L646L	NM_001017403	NP_001017403	Q9HBX8	LGR6_HUMAN	leucine-rich repeat-containing G protein-coupled	785	Helical; Name=6; (Potential).					integral to membrane|plasma membrane	protein-hormone receptor activity			large_intestine(4)|ovary(3)|skin(2)|pancreas(1)	10						ACGGGCTCCTCTACTGTCCCG	0.647		NA											13	77					0	0	0	0
REN	5972	broad.mit.edu	37	1	204124994	204124994	+	Missense_Mutation	SNP	A	A	G			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr1:204124994A>G	uc001haq.2	-	9	1057	c.1013T>C	c.(1012-1014)CTG>CCG	p.L338P		NM_000537	NP_000528	P00797	RENI_HUMAN	renin preproprotein	338					angiotensin maturation|regulation of MAPKKK cascade	extracellular space|membrane	aspartic-type endopeptidase activity			skin(3)|central_nervous_system(1)	4	all_cancers(21;0.00965)|Breast(84;0.116)|all_epithelial(62;0.157)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.109)		Aliskiren(DB01258)|Remikiren(DB00212)	TTTGCCTCCCAGGTGGAAAGA	0.572		NA											5	27					0	0	0	0
ELK4	2005	broad.mit.edu	37	1	205589519	205589519	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr1:205589519C>G	uc001hcy.1	-	3	1905	c.655G>C	c.(655-657)GAA>CAA	p.E219Q	ELK4_uc001hcz.2_Missense_Mutation_p.E219Q	NM_001973	NP_001964	P28324	ELK4_HUMAN	ELK4 protein isoform a	219						cytoplasm|nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription cofactor activity				0	Breast(84;0.07)		BRCA - Breast invasive adenocarcinoma(75;0.0908)			ATAGTTTCTTCTGAAGATGGA	0.473		NA	T	SLC45A3	prostate								19	72					0	0	0	0
RASSF5	83593	broad.mit.edu	37	1	206760273	206760273	+	Missense_Mutation	SNP	A	A	G			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr1:206760273A>G	uc001hed.2	+	6	1277	c.1220A>G	c.(1219-1221)GAG>GGG	p.E407G	RASSF5_uc001hec.1_3'UTR|RASSF5_uc001hee.2_3'UTR|RASSF5_uc001hef.2_Missense_Mutation_p.E254G|RASSF5_uc001heg.1_3'UTR	NM_182663	NP_872604	Q8WWW0	RASF5_HUMAN	Ras association (RalGDS/AF-6) domain family 5	407	SARAH.				apoptosis|intracellular signal transduction	cytoplasm|microtubule	metal ion binding|protein binding			ovary(1)	1	Breast(84;0.183)		BRCA - Breast invasive adenocarcinoma(75;0.166)			CAGAAACTGGAGGAGGCCTTA	0.413		NA											3	49					0	0	0	0
INTS7	25896	broad.mit.edu	37	1	212115325	212115325	+	Silent	SNP	C	C	T			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr1:212115325C>T	uc001hiw.1	-	20	2835	c.2730G>A	c.(2728-2730)GTG>GTA	p.V910V	INTS7_uc009xdb.1_Silent_p.V890V|INTS7_uc001hix.1_Silent_p.V786V|INTS7_uc001hiy.1_Silent_p.V896V|INTS7_uc010pta.1_Silent_p.V861V	NM_015434	NP_056249	Q9NVH2	INT7_HUMAN	integrator complex subunit 7	910					snRNA processing	integrator complex	protein binding				0				OV - Ovarian serous cystadenocarcinoma(81;0.00584)|all cancers(67;0.0318)|Epithelial(68;0.0852)		TGGCATCTTTCACAGAAGATT	0.403		NA											28	103					0	0	0	0
ITPKB	3707	broad.mit.edu	37	1	226925078	226925078	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr1:226925078G>A	uc010pvo.1	-	2	422	c.82C>T	c.(82-84)CCC>TCC	p.P28S	ITPKB_uc001hqh.2_Missense_Mutation_p.P28S	NM_002221	NP_002212	P27987	IP3KB_HUMAN	1D-myo-inositol-trisphosphate 3-kinase B	28							ATP binding|calmodulin binding|inositol trisphosphate 3-kinase activity			ovary(4)|central_nervous_system(1)	5		Prostate(94;0.0773)				CTGCCACTGGGCCCCGGGCCG	0.672		NA											9	11					0	0	0	0
CUBN	8029	broad.mit.edu	37	10	17147564	17147564	+	Silent	SNP	A	A	T			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr10:17147564A>T	uc001ioo.2	-	11	1174	c.1122T>A	c.(1120-1122)CCT>CCA	p.P374P		NM_001081	NP_001072	O60494	CUBN_HUMAN	cubilin precursor	374	EGF-like 5.				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			ovary(9)|breast(4)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|kidney(1)	19					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	ACGTGCAGAGAGGTAAGGAAC	0.443		NA											19	28					0	0	0	0
VIM	7431	broad.mit.edu	37	10	17278348	17278348	+	Silent	SNP	G	G	A			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr10:17278348G>A	uc001iou.2	+	9	1742	c.1329G>A	c.(1327-1329)CTG>CTA	p.L443L	VIM_uc001iov.1_Intron|VIM_uc001iow.1_RNA|VIM_uc001iox.1_Silent_p.L443L|VIM_uc001ioy.1_Silent_p.L356L|VIM_uc001ioz.1_RNA|VIM_uc001ipb.1_RNA|VIM_uc009xjv.1_Silent_p.L401L|VIM_uc001ipc.1_Intron	NM_003380	NP_003371	P08670	VIME_HUMAN	vimentin	443	Tail.				cellular component disassembly involved in apoptosis|cellular component movement|interspecies interaction between organisms|muscle filament sliding	cytosol|intermediate filament	protein C-terminus binding|structural constituent of cytoskeleton			large_intestine(1)|lung(1)|ovary(1)|pancreas(1)	4						GGACACTTCTGATTAAGACGG	0.348		NA											63	117					0	0	0	0
ENKUR	219670	broad.mit.edu	37	10	25284722	25284722	+	Silent	SNP	C	C	T			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr10:25284722C>T	uc001isg.1	-	3	465	c.300G>A	c.(298-300)CAG>CAA	p.Q100Q	ENKUR_uc001ish.1_Silent_p.Q38Q	NM_145010	NP_659447	Q8TC29	ENKUR_HUMAN	enkurin	100						cilium|flagellum	calmodulin binding|SH3 domain binding				0						TTTTTCCACTCTGTATTCCCA	0.358		NA											27	94					0	0	0	0
ZNF239	8187	broad.mit.edu	37	10	44052584	44052584	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr10:44052584C>G	uc001jaw.3	-	2	1597	c.944G>C	c.(943-945)GGA>GCA	p.G315A	ZNF239_uc001jax.3_Missense_Mutation_p.G315A|ZNF239_uc009xmj.2_Missense_Mutation_p.G315A|ZNF239_uc009xmk.2_Missense_Mutation_p.G315A	NM_005674	NP_005665	Q16600	ZN239_HUMAN	zinc finger protein 239	315					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|RNA binding|zinc ion binding				0						GGGCTTCTCTCCAGTGTGGAC	0.522		NA											15	68					0	0	0	0
JMJD1C	221037	broad.mit.edu	37	10	64968896	64968896	+	Missense_Mutation	SNP	G	G	T			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr10:64968896G>T	uc001jmn.2	-	9	3094	c.2794C>A	c.(2794-2796)CCT>ACT	p.P932T	JMJD1C_uc001jml.2_Missense_Mutation_p.P713T|JMJD1C_uc001jmm.2_Missense_Mutation_p.P644T|JMJD1C_uc010qiq.1_Missense_Mutation_p.P750T|JMJD1C_uc009xpi.2_Missense_Mutation_p.P750T|JMJD1C_uc009xpj.1_RNA|JMJD1C_uc009xpk.1_5'Flank	NM_032776	NP_116165	Q15652	JHD2C_HUMAN	jumonji domain containing 1C isoform a	932					blood coagulation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm	histone demethylase activity (H3-K9 specific)|metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|thyroid hormone receptor binding			ovary(4)|breast(1)|central_nervous_system(1)	6	Prostate(12;0.0119)|all_hematologic(501;0.191)					GGCCGATGAGGCTCTGCACTG	0.443		NA											57	44					2.21e-31	2.53e-31	1	0
HTR7	3363	broad.mit.edu	37	10	92508597	92508598	+	Silent	DNP	GC	GC	AA			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr10:92508597_92508598GC>AA	uc001kha.2	-	2	1536_1537	c.1293_1294GC>TT	c.(1291-1296)GTGCTG>GTTTTG	p.431_432VL>VL	HTR7_uc001kgz.2_Silent_p.431_432VL>VL|HTR7_uc001khb.2_Silent_p.431_432VL>VL	NM_019859	NP_062873	P34969	5HT7R_HUMAN	5-hydroxytryptamine receptor 7 isoform d	431_432	Cytoplasmic (By similarity).				blood circulation|circadian rhythm	integral to plasma membrane	protein binding|serotonin receptor activity			ovary(1)	1					Eletriptan(DB00216)|Methysergide(DB00247)|Ziprasidone(DB00246)	TGACCTTACAGCACAAACTCAG	0.48		NA											45	108					0	0	0	0
PLCE1	51196	broad.mit.edu	37	10	95892095	95892095	+	Silent	SNP	C	C	G			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr10:95892095C>G	uc001kjk.2	+	3	2005	c.1371C>G	c.(1369-1371)CTC>CTG	p.L457L	PLCE1_uc010qnx.1_Silent_p.L457L|PLCE1_uc001kjm.2_Silent_p.L149L	NM_016341	NP_057425	Q9P212	PLCE1_HUMAN	phospholipase C, epsilon 1 isoform 1	457					activation of MAPK activity|activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|calcium-mediated signaling|cell proliferation|cytoskeleton organization|diacylglycerol biosynthetic process|elevation of cytosolic calcium ion concentration|epidermal growth factor receptor signaling pathway|glomerulus development|heart development|lipid catabolic process|Ras protein signal transduction|regulation of cell growth|regulation of G-protein coupled receptor protein signaling pathway|regulation of Ras protein signal transduction|regulation of smooth muscle contraction	cytosol|Golgi membrane|membrane fraction|plasma membrane	calcium ion binding|guanyl-nucleotide exchange factor activity|phosphatidylinositol phospholipase C activity|Ras GTPase binding|receptor signaling protein activity			ovary(2)|skin(1)	3		Colorectal(252;0.0458)				GCGCCACCCTCCAAAGGACTT	0.517		NA											65	64					0	0	0	0
C10orf84	63877	broad.mit.edu	37	10	120094625	120094625	+	Splice_Site	SNP	C	C	A			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr10:120094625C>A	uc001ldo.2	-	6	720	c.453_splice	c.e6+1	p.K151_splice	C10orf84_uc010qss.1_Splice_Site_p.K151_splice	NM_022063	NP_071346	Q9H8W3	F204A_HUMAN	hypothetical protein LOC63877												0		Colorectal(252;0.101)		all cancers(201;0.0244)		AAAGATATTACCTTCTCAACT	0.363		NA											6	51					0.00307968	0.00316752	1	0
KNDC1	85442	broad.mit.edu	37	10	135020757	135020757	+	Silent	SNP	C	C	T			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr10:135020757C>T	uc001llz.1	+	20	3697	c.3696C>T	c.(3694-3696)CTC>CTT	p.L1232L		NM_152643	NP_689856	Q76NI1	VKIND_HUMAN	kinase non-catalytic C-lobe domain (KIND)	1232					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction					upper_aerodigestive_tract(1)|ovary(1)	2		all_cancers(35;4.16e-10)|all_epithelial(44;2.07e-08)|Lung NSC(174;0.000845)|all_lung(145;0.00145)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.173)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;8.77e-06)|Epithelial(32;1.13e-05)|all cancers(32;1.51e-05)		CCTCCTCGCTCATCTTCTACA	0.677		NA											12	60					0	0	0	0
OR51G1	79324	broad.mit.edu	37	11	4944942	4944942	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr11:4944942C>T	uc010qyr.1	-	1	628	c.628G>A	c.(628-630)GGT>AGT	p.G210S		NM_001005237	NP_001005237	Q8NGK1	O51G1_HUMAN	olfactory receptor, family 51, subfamily G,	210	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;2.58e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0284)|LUSC - Lung squamous cell carcinoma(625;0.19)		GAGTCCACACCCACGGTGCAG	0.552		NA											8	28					0	0	0	0
ELP4	26610	broad.mit.edu	37	11	31625408	31625408	+	Missense_Mutation	SNP	T	T	G			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr11:31625408T>G	uc001mtb.2	+	5	642	c.607T>G	c.(607-609)TTT>GTT	p.F203V	ELP4_uc001mta.1_RNA|ELP4_uc001mtc.2_Missense_Mutation_p.F203V|ELP4_uc010rdz.1_Missense_Mutation_p.F204V	NM_019040	NP_061913	Q96EB1	ELP4_HUMAN	elongation protein 4 homolog	203					histone acetylation|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|DNA-directed RNA polymerase II, holoenzyme|Elongator holoenzyme complex|transcription elongation factor complex	phosphorylase kinase regulator activity|protein binding			upper_aerodigestive_tract(1)|ovary(1)|prostate(1)	3	Lung SC(675;0.225)					TTGGCATGGATTTTTTCTTCC	0.328		NA											21	58					0	0	0	0
OR8H2	390151	broad.mit.edu	37	11	55872567	55872567	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr11:55872567G>A	uc010riy.1	+	1	49	c.49G>A	c.(49-51)GGA>AGA	p.G17R		NM_001005200	NP_001005200	Q8N162	OR8H2_HUMAN	olfactory receptor, family 8, subfamily H,	17	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	Esophageal squamous(21;0.00693)					CATCCTTATGGGACTGACACT	0.408		NA								HNSCC(53;0.14)			28	124					0	0	0	0
SSRP1	6749	broad.mit.edu	37	11	57100270	57100270	+	Silent	SNP	G	G	A			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr11:57100270G>A	uc001njt.2	-	6	864	c.597C>T	c.(595-597)ATC>ATT	p.I199I	SSRP1_uc010rjq.1_Silent_p.I199I	NM_003146	NP_003137	Q08945	SSRP1_HUMAN	structure specific recognition protein 1	199					DNA repair|DNA replication|positive regulation of viral transcription|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|viral reproduction	chromosome|cytoplasm|nucleoplasm	DNA binding|protein binding			ovary(2)	2						GGAAGATGCAGATGGCATCTC	0.537		NA											8	32					0	0	0	0
TMEM109	79073	broad.mit.edu	37	11	60689394	60689394	+	Silent	SNP	G	G	C			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr11:60689394G>C	uc001nqg.2	+	4	867	c.489G>C	c.(487-489)CTG>CTC	p.L163L	TMEM109_uc001nqh.2_Silent_p.L163L|TMEM132A_uc001nqi.2_5'Flank|TMEM132A_uc001nqj.2_5'Flank	NM_024092	NP_076997	Q9BVC6	TM109_HUMAN	transmembrane protein 109 precursor	163	Helical; (Potential).					integral to membrane|nuclear outer membrane|sarcoplasmic reticulum membrane					0						TGTGGGGCCTGAAGCTTGTCA	0.652		NA											25	88					0	0	0	0
STIP1	10963	broad.mit.edu	37	11	63965417	63965417	+	Missense_Mutation	SNP	A	A	G			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr11:63965417A>G	uc001nyk.1	+	8	1141	c.994A>G	c.(994-996)ACC>GCC	p.T332A	STIP1_uc010rnb.1_Missense_Mutation_p.T308A	NM_006819	NP_006810	P31948	STIP1_HUMAN	stress-induced-phosphoprotein 1	332	TPR 6.				axon guidance|response to stress	Golgi apparatus|nucleus				ovary(2)|liver(1)	3						AGAGCACCGAACCCCAGATGT	0.403		NA											5	155					0	0	0	0
EHD1	10938	broad.mit.edu	37	11	64645866	64645866	+	Missense_Mutation	SNP	C	C	A			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr11:64645866C>A	uc001obu.1	-	1	326	c.71G>T	c.(70-72)GGG>GTG	p.G24V	EHD1_uc001obv.1_Missense_Mutation_p.G24V|EHD1_uc010rnq.1_Missense_Mutation_p.G38V	NM_006795	NP_006786	Q9H4M9	EHD1_HUMAN	EH-domain containing 1	24					blood coagulation|cholesterol homeostasis|endocytic recycling|intracellular protein transport|low-density lipoprotein particle clearance|positive regulation of cholesterol storage|protein homooligomerization	early endosome membrane|lipid particle|plasma membrane|platelet dense tubular network membrane|recycling endosome membrane	ATP binding|calcium ion binding|GTP binding|GTPase activity|protein binding				0						CTGCCGCAGCCCCTCAGCCAC	0.582		NA											16	19					2.89e-11	3.17e-11	1	0
DPP3	10072	broad.mit.edu	37	11	66272197	66272197	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr11:66272197C>T	uc001oig.1	+	17	2055	c.1993C>T	c.(1993-1995)CGT>TGT	p.R665C	DPP3_uc001oif.1_Missense_Mutation_p.R665C|DPP3_uc010rpe.1_Missense_Mutation_p.R654C|DPP3_uc001oih.1_Silent_p.C32C	NM_005700	NP_005691	Q9NY33	DPP3_HUMAN	dipeptidyl peptidase III	665					proteolysis	cytoplasm	aminopeptidase activity|dipeptidyl-peptidase activity|metal ion binding|metallopeptidase activity			ovary(1)|skin(1)	2						GGTGCTGCTGCGTAAGGAATC	0.592		NA											19	71					0	0	0	0
CCND1	595	broad.mit.edu	37	11	69466006	69466006	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr11:69466006G>C	uc001opa.2	+	5	1053	c.844G>C	c.(844-846)GAC>CAC	p.D282H		NM_053056	NP_444284	P24385	CCND1_HUMAN	cyclin D1	282					cell division|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|mitotic cell cycle G1/S transition DNA damage checkpoint|positive regulation of cyclin-dependent protein kinase activity|positive regulation of protein phosphorylation|response to drug|response to UV-A|S phase of mitotic cell cycle	cyclin-dependent protein kinase holoenzyme complex|cytosol|membrane|nucleoplasm	protein kinase binding			ovary(1)|lung(1)	2	all_cancers(3;2.01e-114)|all_epithelial(3;3.59e-122)|Breast(3;5.4e-34)|all_lung(4;1.99e-21)|Lung NSC(4;4.65e-21)|Hepatocellular(3;8.22e-16)|Melanoma(5;1.89e-05)|Ovarian(3;0.0348)		Epithelial(3;7.2e-57)|all cancers(3;7.75e-51)|BRCA - Breast invasive adenocarcinoma(2;4.9e-48)|Lung(3;1.13e-16)|LUSC - Lung squamous cell carcinoma(11;3.74e-15)|STAD - Stomach adenocarcinoma(18;0.0278)|LUAD - Lung adenocarcinoma(13;0.0537)		Arsenic trioxide(DB01169)	ggaggaggtggaCCTGGCTTG	0.612		NA	T	IGH@|FSTL3	CLL|B-ALL|breast					Multiple Myeloma(6;0.086)			8	4					0	0	0	0
ZNF202	7753	broad.mit.edu	37	11	123601372	123601372	+	Silent	SNP	C	C	T			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr11:123601372C>T	uc001pzd.1	-	4	625	c.225G>A	c.(223-225)CTG>CTA	p.L75L	ZNF202_uc001pzc.1_5'UTR|ZNF202_uc001pze.1_Silent_p.L75L|ZNF202_uc001pzf.1_Silent_p.L75L	NM_003455	NP_003446	O95125	ZN202_HUMAN	zinc finger protein 202	75	SCAN box.				lipid metabolic process|negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1		Breast(109;0.00204)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;5.1e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.03)		TCTCTGGTCTCAGCCACTGGT	0.562		NA											19	48					0	0	0	0
ST3GAL4	6484	broad.mit.edu	37	11	126276890	126276890	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr11:126276890G>A	uc001qds.2	+	4	373	c.154G>A	c.(154-156)GAG>AAG	p.E52K	ST3GAL4_uc001qdt.2_Missense_Mutation_p.E48K|ST3GAL4_uc009zcc.2_5'UTR|ST3GAL4_uc009zcd.2_Missense_Mutation_p.E41K|ST3GAL4_uc001qdu.2_Missense_Mutation_p.E48K|ST3GAL4_uc001qdv.2_Missense_Mutation_p.E52K|ST3GAL4_uc009zce.2_Missense_Mutation_p.E48K|ST3GAL4_uc001qdw.2_Missense_Mutation_p.E41K|ST3GAL4_uc001qdx.1_Missense_Mutation_p.E41K|ST3GAL4_uc001qdy.2_5'UTR|ST3GAL4_uc001qdz.2_5'Flank	NM_006278	NP_006269	Q11206	SIA4C_HUMAN	ST3 beta-galactoside alpha-2,3-sialyltransferase	52	Lumenal (Potential).				post-translational protein modification|protein N-linked glycosylation via asparagine	extracellular region|Golgi cisterna membrane|integral to Golgi membrane	beta-galactoside alpha-2,3-sialyltransferase activity				0	all_hematologic(175;0.145)	Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.0739)|all_lung(97;0.0798)|all_neural(223;0.138)		BRCA - Breast invasive adenocarcinoma(274;1.13e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0767)		GGGTGAGGCAGAGAGCAAGGC	0.542		NA											15	49					0	0	0	0
IGSF9B	22997	broad.mit.edu	37	11	133790784	133790784	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr11:133790784G>C	uc001qgx.3	-	18	3067	c.2836C>G	c.(2836-2838)CGG>GGG	p.R946G		NM_014987	NP_055802	Q9UPX0	TUTLB_HUMAN	immunoglobulin superfamily, member 9B	946	Pro-rich.|Cytoplasmic (Potential).					integral to membrane|plasma membrane					0	all_hematologic(175;0.127)	all_cancers(12;1.58e-21)|all_epithelial(12;5.17e-16)|all_lung(97;1.6e-05)|Lung NSC(97;3.86e-05)|Breast(109;0.000126)|Medulloblastoma(222;0.0245)|all_neural(223;0.0505)|Esophageal squamous(93;0.0559)		Epithelial(10;7.19e-10)|BRCA - Breast invasive adenocarcinoma(10;9.69e-09)|all cancers(11;1.23e-08)|OV - Ovarian serous cystadenocarcinoma(99;0.00328)|Lung(977;0.221)		GCCTGAAGCCGACCTTCCAGG	0.697		NA											14	25					0	0	0	0
C12orf4	57102	broad.mit.edu	37	12	4643433	4643433	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr12:4643433C>G	uc001qms.2	-	3	302	c.214G>C	c.(214-216)GAA>CAA	p.E72Q	C12orf4_uc001qmt.2_Missense_Mutation_p.E72Q	NM_020374	NP_065107	Q9NQ89	CL004_HUMAN	hypothetical protein LOC57102	72											0			Colorectal(7;0.00165)|COAD - Colon adenocarcinoma(12;0.0229)	BRCA - Breast invasive adenocarcinoma(232;0.0281)		CTGAGGGATTCTTCTTCTATA	0.423		NA											11	32					0	0	0	0
DNM1L	10059	broad.mit.edu	37	12	32890803	32890803	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr12:32890803C>G	uc001rld.2	+	15	1762	c.1601C>G	c.(1600-1602)TCT>TGT	p.S534C	DNM1L_uc001rle.2_Intron|DNM1L_uc001rlf.2_Intron|DNM1L_uc010skh.1_Missense_Mutation_p.S600C|DNM1L_uc001rlg.2_Missense_Mutation_p.S600C|DNM1L_uc001rlh.2_Missense_Mutation_p.S587C|DNM1L_uc010ski.1_Missense_Mutation_p.S331C	NM_012062	NP_036192	O00429	DNM1L_HUMAN	dynamin 1-like isoform 1	534	Interaction with GSK3B.|B domain.				cellular component disassembly involved in apoptosis|mitochondrial fragmentation involved in apoptosis|mitochondrial membrane organization|positive regulation of mitochondrial fission	cis-Golgi network|cytosol|endomembrane system|endoplasmic reticulum|mitochondrial outer membrane	GTP binding|GTPase activity|ubiquitin protein ligase binding			ovary(1)|pancreas(1)	2	Lung NSC(5;2.15e-06)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.239)					CTTTAGTCTTCTAAAGTTCCA	0.433		NA											10	39					0	0	0	0
MLL2	8085	broad.mit.edu	37	12	49433388	49433388	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr12:49433388G>A	uc001rta.3	-	32	8059	c.8059C>T	c.(8059-8061)CGA>TGA	p.R2687*		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	2687	Potential.|LXXLL motif 1.				chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						AGCAGCTCTCGTAGTCGCTGG	0.572		NA	N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			10	15					0	0	0	0
AQP6	363	broad.mit.edu	37	12	50367243	50367243	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr12:50367243C>G	uc001rvr.1	+	1	624	c.287C>G	c.(286-288)TCT>TGT	p.S96C	AQP6_uc001rvp.1_Intron|AQP6_uc001rvq.1_RNA	NM_001652	NP_001643	Q13520	AQP6_HUMAN	aquaporin 6	96	Cytoplasmic (Potential).				excretion|odontogenesis	integral to plasma membrane|transport vesicle membrane	anion channel activity|water channel activity				0						TCCCACATCTCTCTGCCCCGT	0.677		NA											15	37					0	0	0	0
KRT6A	3853	broad.mit.edu	37	12	52884660	52884660	+	Silent	SNP	C	C	T			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr12:52884660C>T	uc001sam.2	-	4	1103	c.894G>A	c.(892-894)CTG>CTA	p.L298L		NM_005554	NP_005545	P02538	K2C6A_HUMAN	keratin 6A	298	Coil 1B.|Rod.				cell differentiation|ectoderm development|positive regulation of cell proliferation	keratin filament	protein binding|structural constituent of cytoskeleton			ovary(4)|skin(1)	5				BRCA - Breast invasive adenocarcinoma(357;0.189)		ACAAGGCTCTCAGGAAGTTGA	0.488		NA											13	79					0	0	0	0
OR6C4	341418	broad.mit.edu	37	12	55945429	55945429	+	Missense_Mutation	SNP	T	T	C			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr12:55945429T>C	uc010spp.1	+	1	419	c.419T>C	c.(418-420)ATA>ACA	p.I140T		NM_001005494	NP_001005494	Q8NGE1	OR6C4_HUMAN	olfactory receptor, family 6, subfamily C,	140	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						AGAGTCTGCATACAACTAGTG	0.468		NA											13	107					0	0	0	0
DPY19L2	283417	broad.mit.edu	37	12	64055144	64055144	+	Missense_Mutation	SNP	G	G	A	rs140337663		TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr12:64055144G>A	uc001srp.1	-	4	749	c.568C>T	c.(568-570)CGC>TGC	p.R190C	DPY19L2_uc009zqk.1_RNA	NM_173812	NP_776173	Q6NUT2	D19L2_HUMAN	dpy-19-like 2	190					multicellular organismal development|spermatid development	integral to membrane				central_nervous_system(1)|skin(1)	2			GBM - Glioblastoma multiforme(1;2.77e-05)	GBM - Glioblastoma multiforme(28;0.044)		AGATGGAAGCGTTTTATTGCA	0.333		NA											21	69					0	0	0	0
ANKS1B	56899	broad.mit.edu	37	12	99640336	99640336	+	Missense_Mutation	SNP	C	C	A			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr12:99640336C>A	uc001tge.1	-	13	2480	c.2063G>T	c.(2062-2064)GGC>GTC	p.G688V	ANKS1B_uc001tgf.1_Missense_Mutation_p.G268V|ANKS1B_uc001tgk.2_5'UTR|ANKS1B_uc009ztt.1_Missense_Mutation_p.G654V	NM_152788	NP_690001	Q7Z6G8	ANS1B_HUMAN	cajalin 2 isoform a	688						Cajal body|cell junction|cytoplasm|dendritic spine|postsynaptic density|postsynaptic membrane					0		all_cancers(3;0.0197)|all_epithelial(3;0.0101)|Esophageal squamous(3;0.0559)|Breast(359;0.209)		OV - Ovarian serous cystadenocarcinoma(2;2.89e-08)|Epithelial(2;6.12e-08)|all cancers(2;4.07e-06)		TGATCTTGTGCCAACAATGGT	0.433		NA											8	38					0.00307968	0.00316752	1	0
BRAP	8315	broad.mit.edu	37	12	112097072	112097072	+	Silent	SNP	C	C	T			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr12:112097072C>T	uc001tsn.3	-	8	1244	c.1050G>A	c.(1048-1050)GAG>GAA	p.E350E	BRAP_uc010syh.1_Silent_p.E171E|BRAP_uc009zvv.2_Silent_p.E320E	NM_006768	NP_006759	Q7Z569	BRAP_HUMAN	BRCA1 associated protein	350	UBP-type.				MAPKKK cascade|negative regulation of signal transduction|Ras protein signal transduction	cytoplasm|ubiquitin ligase complex	identical protein binding|nuclear localization sequence binding|nucleotide binding|ubiquitin-protein ligase activity|zinc ion binding			lung(1)	1						GCTGCGTTTCCTCAAAGTGCT	0.448		NA											9	69					0	0	0	0
WDR66	144406	broad.mit.edu	37	12	122413157	122413157	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr12:122413157G>A	uc009zxk.2	+	18	2921	c.2779G>A	c.(2779-2781)GAG>AAG	p.E927K		NM_144668	NP_653269	Q8TBY9	WDR66_HUMAN	WD repeat domain 66	927	WD 9.						calcium ion binding			ovary(1)|skin(1)	2	all_neural(191;0.0496)|Medulloblastoma(191;0.0922)			OV - Ovarian serous cystadenocarcinoma(86;0.000155)|Epithelial(86;0.000634)|BRCA - Breast invasive adenocarcinoma(302;0.248)		CAGTGTCCTGGAGGCAGCGGT	0.527		NA											11	39					0	0	0	0
NCOR2	9612	broad.mit.edu	37	12	124812114	124812114	+	Missense_Mutation	SNP	T	T	C			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr12:124812114T>C	uc010tay.1	-	47	7210	c.7054A>G	c.(7054-7056)ATA>GTA	p.I2352V	NCOR2_uc010taz.1_Missense_Mutation_p.I2336V|NCOR2_uc010tax.1_Intron	NM_006312	NP_006303	Q9Y618	NCOR2_HUMAN	nuclear receptor co-repressor 2 isoform 1	2353	CORNR box of ID2.				cellular lipid metabolic process|negative regulation of transcription from RNA polymerase II promoter|regulation of cellular ketone metabolic process by negative regulation of transcription from an RNA polymerase II promoter|transcription, DNA-dependent	nuclear body|nucleus|transcriptional repressor complex	DNA binding|histone deacetylase binding|Notch binding|protein N-terminus binding|transcription corepressor activity			skin(3)|ovary(1)	4	all_neural(191;0.0804)|Medulloblastoma(191;0.163)			Epithelial(86;3.99e-05)|OV - Ovarian serous cystadenocarcinoma(86;9.14e-05)|all cancers(50;0.000402)|BRCA - Breast invasive adenocarcinoma(302;0.0764)		TTTCTAATTATGGCCTCCAGC	0.488		NA											16	23					0	0	0	0
ZNF10	7556	broad.mit.edu	37	12	133732548	133732548	+	Missense_Mutation	SNP	A	A	T			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr12:133732548A>T	uc009zzb.2	+	5	1163	c.716A>T	c.(715-717)AAA>ATA	p.K239I	ZNF268_uc010tbv.1_Intron|ZNF10_uc001ulq.2_Missense_Mutation_p.K239I	NM_015394	NP_056209	P21506	ZNF10_HUMAN	zinc finger protein 10	239				Missing (in Ref. 1).	regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			breast(1)|central_nervous_system(1)|skin(1)	3	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_cancers(7;1.28e-06)|all_epithelial(31;0.0051)|Lung NSC(355;0.00948)		OV - Ovarian serous cystadenocarcinoma(86;3.58e-08)|Epithelial(86;6.6e-07)|all cancers(50;2.28e-05)		AAATCCTACAAATGCCCTGAT	0.373		NA											27	48					0	0	0	0
MAB21L1	4081	broad.mit.edu	37	13	36050182	36050182	+	Silent	SNP	G	G	T			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr13:36050182G>T	uc001uvc.2	-	1	651	c.94C>A	c.(94-96)CGG>AGG	p.R32R	NBEA_uc001uvb.2_Intron|NBEA_uc010abi.2_Intron|NBEA_uc010tee.1_Intron|NBEA_uc010tef.1_5'Flank|NBEA_uc010teg.1_5'Flank	NM_005584	NP_005575	Q13394	MB211_HUMAN	mab-21-like protein 1	32					anatomical structure morphogenesis	nucleus				ovary(2)	2		Breast(139;0.014)|Lung SC(185;0.051)|Prostate(109;0.202)		all cancers(112;9.63e-08)|Epithelial(112;1.37e-06)|BRCA - Breast invasive adenocarcinoma(63;0.000659)|OV - Ovarian serous cystadenocarcinoma(117;0.00372)|GBM - Glioblastoma multiforme(144;0.115)		CAGACTTCCCGGATAGTTTTG	0.512		NA											18	73					1.38e-19	1.55e-19	1	0
SLITRK6	84189	broad.mit.edu	37	13	86369500	86369500	+	Missense_Mutation	SNP	C	C	A			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr13:86369500C>A	uc001vll.1	-	2	1603	c.1144G>T	c.(1144-1146)GAT>TAT	p.D382Y	SLITRK6_uc010afe.1_Intron	NM_032229	NP_115605	Q9H5Y7	SLIK6_HUMAN	slit and trk like 6 precursor	382	Extracellular (Potential).|LRR 6.					integral to membrane				large_intestine(1)|ovary(1)|central_nervous_system(1)	3	all_neural(89;0.117)|Medulloblastoma(90;0.163)			GBM - Glioblastoma multiforme(99;0.0456)		TCCACTAGATCAGACTTCATT	0.378		NA											32	46					1.07e-11	1.18e-11	1	0
ATP11A	23250	broad.mit.edu	37	13	113439521	113439521	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr13:113439521G>C	uc001vsi.3	+	2	200	c.112G>C	c.(112-114)GAG>CAG	p.E38Q	ATP11A_uc001vsj.3_Missense_Mutation_p.E38Q|ATP11A_uc001vsm.1_5'UTR	NM_015205	NP_056020	P98196	AT11A_HUMAN	ATPase, class VI, type 11A isoform a	38	Cytoplasmic (Potential).				ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			large_intestine(2)|ovary(2)	4	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)	all_lung(25;0.134)|all_epithelial(44;0.141)				TCCGGGCGCAGAGGCCTACAT	0.557		NA									OREG0003855	type=REGULATORY REGION|Gene=ATP11A|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	17	74					0	0	0	0
ATP11A	23250	broad.mit.edu	37	13	113464990	113464990	+	Missense_Mutation	SNP	C	C	A			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr13:113464990C>A	uc001vsi.3	+	5	479	c.391C>A	c.(391-393)CAT>AAT	p.H131N	ATP11A_uc001vsj.3_Missense_Mutation_p.H131N|ATP11A_uc001vsm.1_Missense_Mutation_p.H7N	NM_015205	NP_056020	P98196	AT11A_HUMAN	ATPase, class VI, type 11A isoform a	131	Cytoplasmic (Potential).				ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			large_intestine(2)|ovary(2)	4	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)	all_lung(25;0.134)|all_epithelial(44;0.141)				GTGTCCTGTTCATTTCATTCA	0.323		NA											18	124					8.01e-06	8.52e-06	1	0
MDGA2	161357	broad.mit.edu	37	14	47426600	47426600	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr14:47426600C>T	uc001wwj.3	-	9	2055	c.1859G>A	c.(1858-1860)GGG>GAG	p.G620E	MDGA2_uc001wwi.3_Missense_Mutation_p.G391E|MDGA2_uc010ani.2_Missense_Mutation_p.G180E	NM_001113498	NP_001106970	Q7Z553	MDGA2_HUMAN	MAM domain containing 1 isoform 1	620	Ig-like 6.				spinal cord motor neuron differentiation	anchored to membrane|plasma membrane				ovary(4)|large_intestine(1)|pancreas(1)	6						GCTGCATCTCCCAGCTCCAGC	0.358		NA											17	35					0	0	0	0
NID2	22795	broad.mit.edu	37	14	52535538	52535538	+	Missense_Mutation	SNP	C	C	A			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr14:52535538C>A	uc001wzo.2	-	1	409	c.175G>T	c.(175-177)GTG>TTG	p.V59L	NID2_uc010tqs.1_Missense_Mutation_p.V59L|NID2_uc010tqt.1_Missense_Mutation_p.V59L|NID2_uc001wzp.2_Missense_Mutation_p.V59L	NM_007361	NP_031387	Q14112	NID2_HUMAN	nidogen 2 precursor	59						basement membrane	calcium ion binding|collagen binding			pancreas(2)|breast(2)|ovary(1)|liver(1)|skin(1)	7	Breast(41;0.0639)|all_epithelial(31;0.123)					GCCAGCTTCACCACGGCTGAG	0.637		NA											22	37					2.49e-11	2.74e-11	1	0
MLH3	27030	broad.mit.edu	37	14	75485569	75485569	+	Missense_Mutation	SNP	G	G	T			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr14:75485569G>T	uc001xrd.1	-	12	4421	c.4205C>A	c.(4204-4206)CCG>CAG	p.P1402Q	MLH3_uc001xre.1_Missense_Mutation_p.P1378Q	NM_001040108	NP_001035197	Q9UHC1	MLH3_HUMAN	mutL homolog 3 isoform 1	1402					mismatch repair|reciprocal meiotic recombination	chiasma|MutLbeta complex|synaptonemal complex	ATP binding|ATPase activity|mismatched DNA binding|protein binding|satellite DNA binding			ovary(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(234;0.00688)		GTCAGCTAACGGCAGCATAGA	0.468		NA						MMR					25	38					6.13e-19	6.89e-19	1	0
AHNAK2	113146	broad.mit.edu	37	14	105412107	105412107	+	Silent	SNP	G	G	C			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr14:105412107G>C	uc010axc.1	-	7	9801	c.9681C>G	c.(9679-9681)CCC>CCG	p.P3227P	AHNAK2_uc001ypx.2_Silent_p.P3127P	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	3227						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			TCTGCAACTTGGGCAGGTGCC	0.617		NA											34	389					0	0	0	0
SLC12A6	9990	broad.mit.edu	37	15	34538068	34538068	+	Missense_Mutation	SNP	C	C	A			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr15:34538068C>A	uc001zhw.2	-	13	1814	c.1650G>T	c.(1648-1650)AAG>AAT	p.K550N	SLC12A6_uc001zhv.2_Missense_Mutation_p.K499N|SLC12A6_uc001zhx.2_Missense_Mutation_p.K535N|SLC12A6_uc001zhy.2_RNA|SLC12A6_uc001zhz.2_RNA|SLC12A6_uc001zia.2_Missense_Mutation_p.K491N|SLC12A6_uc001zib.2_Missense_Mutation_p.K541N|SLC12A6_uc001zic.2_Missense_Mutation_p.K550N|SLC12A6_uc010bau.2_Missense_Mutation_p.K550N|SLC12A6_uc001zid.2_Missense_Mutation_p.K491N|SLC12A6_uc001zht.2_RNA|SLC12A6_uc001zhu.2_Missense_Mutation_p.K362N	NM_133647	NP_598408	Q9UHW9	S12A6_HUMAN	solute carrier family 12, member 6 isoform a	550	Cytoplasmic (Potential).				angiogenesis|cellular hypotonic salinity response|potassium ion transport|sodium ion transport	basolateral plasma membrane|integral to membrane	potassium:chloride symporter activity			central_nervous_system(5)|ovary(1)|skin(1)	7		all_lung(180;2.78e-08)		all cancers(64;3.43e-17)|GBM - Glioblastoma multiforme(113;2.6e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0301)	Potassium Chloride(DB00761)	CATCACCGAACCTGGGAAAGA	0.373		NA											7	13					0.00198382	0.00204727	1	0
FBN1	2200	broad.mit.edu	37	15	48892392	48892392	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr15:48892392C>T	uc001zwx.1	-	5	714	c.386G>A	c.(385-387)TGC>TAC	p.C129Y		NM_000138	NP_000129	P35555	FBN1_HUMAN	fibrillin 1 precursor	129	EGF-like 2.		C -> Y (in MFS; severe neonatal).		heart development|negative regulation of BMP signaling pathway by extracellular sequestering of BMP|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|skeletal system development	basement membrane|extracellular space|microfibril	calcium ion binding|extracellular matrix structural constituent|protein binding			ovary(2)|large_intestine(1)	3		all_lung(180;0.00279)		all cancers(107;4.24e-07)|GBM - Glioblastoma multiforme(94;1.41e-05)		ATCGTCACTGCAGCTACCTCC	0.378		NA											52	21					0	0	0	0
KIAA1370	56204	broad.mit.edu	37	15	52903845	52903845	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr15:52903845C>T	uc002acg.3	-	4	484	c.331G>A	c.(331-333)GAT>AAT	p.D111N	KIAA1370_uc002ach.3_RNA|KIAA1370_uc010bfg.1_Missense_Mutation_p.D23N|KIAA1370_uc010ugf.1_Missense_Mutation_p.D118N	NM_019600	NP_062546	Q32MH5	K1370_HUMAN	hypothetical protein LOC56204	111											0				all cancers(107;0.0803)		TCATTTAGATCAATTCCCTCT	0.428		NA											14	39					0	0	0	0
UNC13C	440279	broad.mit.edu	37	15	54914565	54914565	+	Silent	SNP	T	T	C			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr15:54914565T>C	uc002ack.2	+	29	6147	c.6147T>C	c.(6145-6147)CAT>CAC	p.H2049H	UNC13C_uc002acm.2_5'UTR	NM_001080534	NP_001074003	Q8NB66	UN13C_HUMAN	unc-13 homolog C	2049	C2 2.				exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			ovary(5)|pancreas(2)	7				GBM - Glioblastoma multiforme(80;0.0789)|all cancers(107;0.124)		TATCTGTTCATGTGGACATCA	0.428		NA											61	18					0	0	0	0
CILP	8483	broad.mit.edu	37	15	65490839	65490839	+	Silent	SNP	T	T	C			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr15:65490839T>C	uc002aon.2	-	9	1966	c.1785A>G	c.(1783-1785)GAA>GAG	p.E595E		NM_003613	NP_003604	O75339	CILP1_HUMAN	cartilage intermediate layer protein	595					negative regulation of insulin-like growth factor receptor signaling pathway	extracellular matrix part|extracellular space|proteinaceous extracellular matrix				ovary(4)|pancreas(2)|skin(1)	7						CCATGGGGTCTTCACCAACCA	0.522		NA											29	57					0	0	0	0
CLK3	1198	broad.mit.edu	37	15	74922109	74922109	+	Nonsense_Mutation	SNP	T	T	G			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr15:74922109T>G	uc010uln.1	+	13	2263	c.1802T>G	c.(1801-1803)TTA>TGA	p.L601*	CLK3_uc002ayg.3_Nonsense_Mutation_p.L453*|CLK3_uc002ayh.3_Nonsense_Mutation_p.L232*|CLK3_uc002ayj.3_Nonsense_Mutation_p.L430*|CLK3_uc002ayk.3_Nonsense_Mutation_p.L380*|CLK3_uc002ayl.3_Nonsense_Mutation_p.L286*	NM_001130028	NP_001123500	P49761	CLK3_HUMAN	CDC-like kinase 3 isoform a	601	Protein kinase.					acrosomal vesicle|nucleus	ATP binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			stomach(2)	2						AGGAGGATGTTAGAATTTGAC	0.607		NA											22	5					0	0	0	0
NR2F2	7026	broad.mit.edu	37	15	96875642	96875642	+	Missense_Mutation	SNP	T	T	G			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr15:96875642T>G	uc010uri.1	+	1	1532	c.308T>G	c.(307-309)TTC>TGC	p.F103C	NR2F2_uc002btp.2_Intron|NR2F2_uc010urj.1_5'Flank|MIR1469_hsa-mir-1469|MI0007074_5'Flank|NR2F2_uc010urk.1_5'Flank	NM_021005	NP_066285	P24468	COT2_HUMAN	nuclear receptor subfamily 2, group F, member 2	103	Nuclear receptor.				lipid metabolic process|negative regulation of cyclin-dependent protein kinase activity|negative regulation of endothelial cell migration|negative regulation of endothelial cell proliferation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|regulation of transcription involved in lymphatic endothelial cell fate commitment	nucleus	ligand-regulated transcription factor activity|protein homodimerization activity|retinoic acid binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|transcription corepressor activity|zinc ion binding			ovary(2)|breast(1)	3	Lung NSC(78;0.0186)|Melanoma(26;0.0195)|all_lung(78;0.0297)		OV - Ovarian serous cystadenocarcinoma(32;0.0856)			AAGAGCTTCTTCAAGCGCAGC	0.622		NA											6	11					0	0	0	0
ALDH1A3	220	broad.mit.edu	37	15	101445832	101445832	+	Silent	SNP	C	C	G			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr15:101445832C>G	uc002bwn.3	+	10	1277	c.1173C>G	c.(1171-1173)CTC>CTG	p.L391L	ALDH1A3_uc010bpb.2_Silent_p.L284L|uc002bwo.1_Intron	NM_000693	NP_000684	P47895	AL1A3_HUMAN	aldehyde dehydrogenase 1A3	391					retinal metabolic process	cytoplasm	aldehyde dehydrogenase|protein homodimerization activity			central_nervous_system(2)|lung(1)|pancreas(1)	4	Lung NSC(78;0.00144)|all_lung(78;0.0018)|Melanoma(26;0.00852)		OV - Ovarian serous cystadenocarcinoma(32;0.000932)|LUSC - Lung squamous cell carcinoma(107;0.0766)|Lung(145;0.103)		NADH(DB00157)|Vitamin A(DB00162)	ACAAGGGGCTCTTCATCAAAC	0.537		NA											4	26					0	0	0	0
E4F1	1877	broad.mit.edu	37	16	2273707	2273707	+	Silent	SNP	G	G	A			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr16:2273707G>A	uc002cpm.2	+	1	141	c.93G>A	c.(91-93)GCG>GCA	p.A31A	E4F1_uc010bsi.2_Silent_p.A31A|E4F1_uc010bsj.2_Silent_p.A31A	NM_004424	NP_004415	Q66K89	E4F1_HUMAN	p120E4F	31					cell division|cell proliferation|interspecies interaction between organisms|mitosis|regulation of growth	cytoplasm|nucleoplasm	DNA binding|ligase activity|protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity|zinc ion binding			ovary(1)	1						GTGCAGTTGCGGCGGTGGCGG	0.751		NA											7	2					0	0	0	0
ATXN2L	11273	broad.mit.edu	37	16	28844640	28844640	+	Silent	SNP	C	C	T			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr16:28844640C>T	uc002drc.2	+	14	2088	c.1920C>T	c.(1918-1920)ATC>ATT	p.I640I	uc010vct.1_Intron|ATXN2L_uc010byl.1_Silent_p.I616I|ATXN2L_uc002drb.2_Silent_p.I640I|ATXN2L_uc002dqy.2_Silent_p.I640I|ATXN2L_uc002dra.2_Silent_p.I640I|ATXN2L_uc002dqz.2_Silent_p.I640I|ATXN2L_uc010vdb.1_Silent_p.I646I|ATXN2L_uc002dre.2_Silent_p.I640I|ATXN2L_uc002drf.2_Silent_p.I49I|ATXN2L_uc002drg.2_5'Flank	NM_007245	NP_009176	Q8WWM7	ATX2L_HUMAN	ataxin 2 related protein isoform A	640						membrane				upper_aerodigestive_tract(1)|ovary(1)	2						TGGGCCTCATCAAGGGAGAAG	0.622		NA											18	46					0	0	0	0
TBX6	6911	broad.mit.edu	37	16	30100461	30100461	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr16:30100461C>G	uc010veh.1	-	4	484	c.424G>C	c.(424-426)GAT>CAT	p.D142H	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|TBX6_uc002dwk.1_Missense_Mutation_p.D142H	NM_004608	NP_004599	O95947	TBX6_HUMAN	T-box 6	142	T-box.				anatomical structure morphogenesis|mesoderm development|multicellular organismal development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|pancreas(1)	2						GGAATCACATCCAGAAGAAAC	0.662		NA											17	72					0	0	0	0
CNGB1	1258	broad.mit.edu	37	16	57973358	57973358	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr16:57973358C>T	uc002emt.2	-	16	1413	c.1348G>A	c.(1348-1350)GAG>AAG	p.E450K	CNGB1_uc010cdh.2_Missense_Mutation_p.E444K	NM_001297	NP_001288	Q14028	CNGB1_HUMAN	cyclic nucleotide gated channel beta 1 isoform	450	Cytoplasmic (Potential).				sensory perception of smell	intracellular cyclic nucleotide activated cation channel complex	cAMP binding|intracellular cAMP activated cation channel activity			breast(3)|pancreas(1)	4						GCCTCGGCCTCAGCCTCAGGc	0.328		NA											7	26					0	0	0	0
CENPN	55839	broad.mit.edu	37	16	81061821	81061821	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr16:81061821G>A	uc002ffx.2	+	10	1646	c.856G>A	c.(856-858)GAG>AAG	p.E286K	CENPN_uc010vnl.1_Missense_Mutation_p.E252K|CENPN_uc010vnm.1_Missense_Mutation_p.E266K|CENPN_uc002ffy.3_Missense_Mutation_p.E286K	NM_001100624	NP_001094094	Q96H22	CENPN_HUMAN	centromere protein N isoform 2	286					CenH3-containing nucleosome assembly at centromere|mitotic prometaphase	condensed chromosome kinetochore|cytosol|nucleoplasm					0						CATCTTGGCTGAGAGGGAAGA	0.403		NA											11	49					0	0	0	0
PKD1L2	114780	broad.mit.edu	37	16	81183305	81183305	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr16:81183305C>G	uc002fgh.1	-	28	4743	c.4743G>C	c.(4741-4743)AAG>AAC	p.K1581N	PKD1L2_uc002fgg.1_RNA	NM_052892	NP_443124	Q7Z442	PK1L2_HUMAN	polycystin 1-like 2 isoform a	1581	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity|sugar binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3						CCAAGTCCATCTTTTGCTCAG	0.557		NA											5	19					0	0	0	0
DNAH2	146754	broad.mit.edu	37	17	7736073	7736073	+	Silent	SNP	C	C	T			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr17:7736073C>T	uc002giu.1	+	82	12917	c.12903C>T	c.(12901-12903)AAC>AAT	p.N4301N		NM_020877	NP_065928	Q9P225	DYH2_HUMAN	dynein heavy chain domain 3	4301					ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(6)|skin(6)|central_nervous_system(1)	13		all_cancers(10;4.66e-07)|Prostate(122;0.081)				GCCAAAACAACGTGAGCAATG	0.557		NA											172	43					0	0	0	0
MYH2	4620	broad.mit.edu	37	17	10433049	10433049	+	Missense_Mutation	SNP	G	G	T			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr17:10433049G>T	uc010coi.2	-	24	3077	c.2949C>A	c.(2947-2949)AAC>AAA	p.N983K	uc002gml.1_Intron|MYH2_uc002gmp.3_Missense_Mutation_p.N983K|MYH2_uc010coj.2_Intron	NM_001100112	NP_001093582	Q9UKX2	MYH2_HUMAN	myosin heavy chain IIa	983	Potential.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(5)|pancreas(4)|skin(3)|lung(1)|kidney(1)	14						CTTCTGTGAGGTTTTTCACCT	0.473		NA											90	87					2.69e-43	3.08e-43	1	0
NCOR1	9611	broad.mit.edu	37	17	16068406	16068406	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr17:16068406G>C	uc002gpo.2	-	5	745	c.505C>G	c.(505-507)CAA>GAA	p.Q169E	NCOR1_uc002gpn.2_Missense_Mutation_p.Q169E|NCOR1_uc002gpp.1_Missense_Mutation_p.Q60E|NCOR1_uc002gpr.2_Missense_Mutation_p.Q60E|NCOR1_uc002gps.1_Missense_Mutation_p.Q169E|NCOR1_uc010coz.1_Translation_Start_Site|NCOR1_uc010cpb.1_Missense_Mutation_p.Q169E|NCOR1_uc010cpa.1_Missense_Mutation_p.Q169E|NCOR1_uc002gpu.2_Missense_Mutation_p.Q169E	NM_006311	NP_006302	O75376	NCOR1_HUMAN	nuclear receptor co-repressor 1	169	Interaction with ZBTB33 and HEXIM1.				cellular lipid metabolic process|chromatin modification|negative regulation of JNK cascade|regulation of glycolysis by negative regulation of transcription from an RNA polymerase II promoter|regulation of lipid transport by negative regulation of transcription from an RNA polymerase II promoter|spindle assembly|transcription from RNA polymerase II promoter	nuclear chromatin|spindle microtubule|transcriptional repressor complex	histone deacetylase binding|transcription corepressor activity|transcription regulatory region DNA binding			upper_aerodigestive_tract(2)|ovary(1)|central_nervous_system(1)|kidney(1)	5				UCEC - Uterine corpus endometrioid carcinoma (92;0.101)		GAAGCATTTTGATCATCTCCA	0.393		NA											10	76					0	0	0	0
NCOR1	9611	broad.mit.edu	37	17	16068472	16068472	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr17:16068472G>A	uc002gpo.2	-	5	679	c.439C>T	c.(439-441)CCA>TCA	p.P147S	NCOR1_uc002gpn.2_Missense_Mutation_p.P147S|NCOR1_uc002gpp.1_Missense_Mutation_p.P38S|NCOR1_uc002gpr.2_Missense_Mutation_p.P38S|NCOR1_uc002gps.1_Missense_Mutation_p.P147S|NCOR1_uc010coz.1_5'UTR|NCOR1_uc010cpb.1_Missense_Mutation_p.P147S|NCOR1_uc010cpa.1_Missense_Mutation_p.P147S|NCOR1_uc002gpu.2_Missense_Mutation_p.P147S	NM_006311	NP_006302	O75376	NCOR1_HUMAN	nuclear receptor co-repressor 1	147	Interaction with ZBTB33 and HEXIM1.				cellular lipid metabolic process|chromatin modification|negative regulation of JNK cascade|regulation of glycolysis by negative regulation of transcription from an RNA polymerase II promoter|regulation of lipid transport by negative regulation of transcription from an RNA polymerase II promoter|spindle assembly|transcription from RNA polymerase II promoter	nuclear chromatin|spindle microtubule|transcriptional repressor complex	histone deacetylase binding|transcription corepressor activity|transcription regulatory region DNA binding			upper_aerodigestive_tract(2)|ovary(1)|central_nervous_system(1)|kidney(1)	5				UCEC - Uterine corpus endometrioid carcinoma (92;0.101)		CCGAATGCTGGATCCTTTAGA	0.393		NA											8	72					0	0	0	0
MYO15A	51168	broad.mit.edu	37	17	18062990	18062990	+	Silent	SNP	G	G	A			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr17:18062990G>A	uc010vxh.1	+	54	9638	c.9300G>A	c.(9298-9300)CTG>CTA	p.L3100L	MYO15A_uc010vxi.1_Silent_p.L364L|MYO15A_uc010vxk.1_Intron|MYO15A_uc010vxl.1_Silent_p.L89L|MYO15A_uc002gsl.2_Silent_p.L22L|MYO15A_uc010vxm.1_Silent_p.L22L|MYO15A_uc002gsm.1_5'Flank|MYO15A_uc010cpv.2_5'Flank	NM_016239	NP_057323	Q9UKN7	MYO15_HUMAN	myosin XV	3100	Tail.|MyTH4 2.				sensory perception of sound	cytoplasm|myosin complex|stereocilium	actin binding|ATP binding|calmodulin binding|motor activity			skin(4)|ovary(2)|pancreas(1)|breast(1)|central_nervous_system(1)	9	all_neural(463;0.228)					GTAACCTCCTGAAGGTCAGTC	0.532		NA											8	28					0	0	0	0
CDK12	51755	broad.mit.edu	37	17	37627593	37627593	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr17:37627593C>G	uc010cvv.2	+	2	2094	c.1508C>G	c.(1507-1509)TCT>TGT	p.S503C	CDK12_uc010wef.1_Missense_Mutation_p.S502C|CDK12_uc002hrw.3_Missense_Mutation_p.S503C	NM_016507	NP_057591	Q9NYV4	CDK12_HUMAN	Cdc2-related kinase, arginine/serine-rich	503					mRNA processing|phosphorylation of RNA polymerase II C-terminal domain|protein autophosphorylation|regulation of MAP kinase activity|RNA splicing	nuclear cyclin-dependent protein kinase holoenzyme complex|nuclear speck|nucleolus	ATP binding|cyclin-dependent protein kinase activity|protein binding|RNA polymerase II carboxy-terminal domain kinase activity			ovary(10)|lung(4)|breast(2)|skin(2)|large_intestine(1)	19						ACAAGAGACTCTAAACCCATA	0.428		NA								TCGA Ovarian(9;0.13)			26	111					0	0	0	0
NMT1	4836	broad.mit.edu	37	17	43159057	43159057	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr17:43159057G>C	uc002ihz.2	+	2	195	c.177G>C	c.(175-177)AAG>AAC	p.K59N	NMT1_uc010dac.1_Intron|NMT1_uc002iia.2_RNA	NM_021079	NP_066565	P30419	NMT1_HUMAN	N-myristoyltransferase 1	59	Poly-Lys.				activation of pro-apoptotic gene products|induction of apoptosis by intracellular signals|N-terminal protein myristoylation|protein lipoylation	actin cytoskeleton|cell junction|cytosol	glycylpeptide N-tetradecanoyltransferase activity				0		Prostate(33;0.155)				agaagaaaaagaaacaaaaaa	0.343		NA											5	28					0	0	0	0
ABCA5	23461	broad.mit.edu	37	17	67287394	67287394	+	Silent	SNP	C	C	T			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr17:67287394C>T	uc002jif.2	-	11	2787	c.1569G>A	c.(1567-1569)TTG>TTA	p.L523L	ABCA5_uc002jie.2_RNA|ABCA5_uc002jig.2_Silent_p.L523L|ABCA5_uc002jih.2_Silent_p.L523L|ABCA5_uc010dfe.2_Silent_p.L523L	NM_018672	NP_061142	Q8WWZ7	ABCA5_HUMAN	ATP-binding cassette, sub-family A , member 5	523	ABC transporter 1.				cholesterol efflux|high-density lipoprotein particle remodeling|negative regulation of macrophage derived foam cell differentiation	Golgi membrane|integral to membrane|late endosome membrane|lysosomal membrane	ATP binding|ATPase activity			ovary(2)|central_nervous_system(1)|skin(1)	4	Breast(10;3.72e-11)					GAATATTCATCAATGTACTCT	0.338		NA											10	46					0	0	0	0
KIF19	124602	broad.mit.edu	37	17	72348997	72348997	+	Nonsense_Mutation	SNP	C	C	G			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr17:72348997C>G	uc002jkm.3	+	15	2156	c.2018C>G	c.(2017-2019)TCA>TGA	p.S673*		NM_153209	NP_694941	Q2TAC6	KIF19_HUMAN	kinesin family member 19	673					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity				0						GCAGGAACCTCACTGACCCCA	0.567		NA											17	91					0	0	0	0
AFMID	125061	broad.mit.edu	37	17	76187113	76187113	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr17:76187113G>C	uc002jva.3	+	2	141	c.126G>C	c.(124-126)TTG>TTC	p.L42F	AFMID_uc002juy.3_RNA|AFMID_uc010dhj.2_Missense_Mutation_p.L42F|AFMID_uc002jvb.3_Missense_Mutation_p.L42F|AFMID_uc002juz.3_Missense_Mutation_p.L42F	NM_001010982	NP_001010982	Q63HM1	AFMID_HUMAN	arylformamidase isoform 1	42						cytosol|nucleus	arylformamidase activity			large_intestine(1)|pancreas(1)	2			BRCA - Breast invasive adenocarcinoma(99;0.00269)|OV - Ovarian serous cystadenocarcinoma(97;0.134)			AGGAAGCCTTGAGGACCTACT	0.542		NA											4	12					0	0	0	0
CCDC40	55036	broad.mit.edu	37	17	78032313	78032313	+	Missense_Mutation	SNP	A	A	G			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr17:78032313A>G	uc010dht.2	+	8	1207	c.1180A>G	c.(1180-1182)ATG>GTG	p.M394V	CCDC40_uc010wub.1_Missense_Mutation_p.M394V|CCDC40_uc002jxm.3_Missense_Mutation_p.M177V	NM_017950	NP_060420	Q4G0X9	CCD40_HUMAN	coiled-coil domain containing 40	394	Potential.				axonemal dynein complex assembly|ciliary cell motility|cilium movement involved in determination of left/right asymmetry|flagellar cell motility	cilium|cytoplasm				ovary(3)	3	all_neural(118;0.167)		OV - Ovarian serous cystadenocarcinoma(97;0.0292)|BRCA - Breast invasive adenocarcinoma(99;0.149)			GCAGACTGAGATGGAGAACTT	0.602		NA											8	37					0	0	0	0
NPLOC4	55666	broad.mit.edu	37	17	79534533	79534533	+	Missense_Mutation	SNP	C	C	A			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr17:79534533C>A	uc002kat.3	-	15	1658	c.1476G>T	c.(1474-1476)TTG>TTT	p.L492F	NPLOC4_uc002kau.3_Missense_Mutation_p.L492F|NPLOC4_uc010wur.1_Missense_Mutation_p.L331F|NPLOC4_uc010dic.2_5'Flank|NPLOC4_uc002kas.2_Missense_Mutation_p.C16F	NM_017921	NP_060391	Q8TAT6	NPL4_HUMAN	nuclear protein localization 4	492					cellular membrane fusion|ER-associated protein catabolic process|Golgi organization	cytosol|endoplasmic reticulum|nuclear outer membrane-endoplasmic reticulum membrane network|nucleus	zinc ion binding			ovary(1)|central_nervous_system(1)	2	all_neural(118;0.0878)|Melanoma(429;0.242)|all_lung(278;0.246)		BRCA - Breast invasive adenocarcinoma(99;0.0282)|OV - Ovarian serous cystadenocarcinoma(97;0.0739)			TATTCTGAGACAAATAGGTGG	0.478		NA											6	9					0.00116845	0.00121194	1	0
HGS	9146	broad.mit.edu	37	17	79667588	79667588	+	Silent	SNP	C	C	T			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr17:79667588C>T	uc002kbg.2	+	19	2051	c.1974C>T	c.(1972-1974)CCC>CCT	p.P658P	MRPL12_uc002kbh.1_5'Flank|SLC25A10_uc010wut.1_5'Flank	NM_004712	NP_004703	O14964	HGS_HUMAN	hepatocyte growth factor-regulated tyrosine	658	Interaction with NF2.|Gln-rich.				cellular membrane organization|endosome transport|epidermal growth factor receptor signaling pathway|intracellular protein transport|negative regulation of cell proliferation|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of JAK-STAT cascade|regulation of protein catabolic process	cytosol|early endosome membrane|multivesicular body membrane	metal ion binding|protein domain specific binding			ovary(1)	1	all_neural(118;0.0878)|all_lung(278;0.23)		BRCA - Breast invasive adenocarcinoma(99;0.0101)|OV - Ovarian serous cystadenocarcinoma(97;0.0955)			CCGCCAGCCCCGCTTACTCAT	0.587		NA											54	7					0	0	0	0
THOC4	10189	broad.mit.edu	37	17	79847182	79847182	+	Silent	SNP	C	C	T			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr17:79847182C>T	uc002kbu.2	-	3	420	c.414G>A	c.(412-414)ACG>ACA	p.T138T	ANAPC11_uc002kbv.1_5'Flank|ANAPC11_uc002kbw.1_5'Flank|ANAPC11_uc002kbx.1_5'Flank|ANAPC11_uc002kby.1_5'Flank|ANAPC11_uc002kbz.1_5'Flank|ANAPC11_uc002kca.1_5'Flank|ANAPC11_uc002kcb.1_5'Flank|ANAPC11_uc002kcc.1_5'Flank	NM_005782	NP_005773	Q86V81	THOC4_HUMAN	THO complex 4	131	RRM.|Ala/Arg/Gly-rich.				intronless viral mRNA export from host nucleus|mRNA 3'-end processing|termination of RNA polymerase II transcription	catalytic step 2 spliceosome|cytosol|nuclear speck|transcription export complex	nucleotide binding|protein binding|RNA binding				0	all_neural(118;0.0878)|Ovarian(332;0.12)		BRCA - Breast invasive adenocarcinoma(99;0.013)|OV - Ovarian serous cystadenocarcinoma(97;0.0382)			CCTTCTTCAGCGTTCCAAATT	0.547		NA											47	15					0	0	0	0
TGIF1	7050	broad.mit.edu	37	18	3456381	3456381	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr18:3456381G>C	uc002klz.2	+	2	820	c.433G>C	c.(433-435)GAG>CAG	p.E145Q	TGIF1_uc002klu.2_5'UTR|TGIF1_uc002klv.2_Missense_Mutation_p.E30Q|TGIF1_uc002klx.2_5'UTR|TGIF1_uc002klw.2_Missense_Mutation_p.E16Q|TGIF1_uc010dkm.1_Missense_Mutation_p.E16Q|TGIF1_uc002kly.2_Missense_Mutation_p.E16Q|TGIF1_uc002kma.2_5'UTR|TGIF1_uc002kmb.2_5'UTR|TGIF1_uc002kmc.2_5'UTR	NM_170695	NP_733796	Q15583	TGIF1_HUMAN	TG-interacting factor isoform a	145					negative regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			ovary(1)	1	Esophageal squamous(4;0.0859)	Colorectal(8;0.0104)				CAGTGAGACTGAGGATGAGGA	0.502		NA											6	563					0	0	0	0
POTEC	388468	broad.mit.edu	37	18	14542916	14542916	+	Missense_Mutation	SNP	G	G	T			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr18:14542916G>T	uc010dln.2	-	1	684	c.230C>A	c.(229-231)ACG>AAG	p.T77K	POTEC_uc010xaj.1_RNA	NM_001137671	NP_001131143	B2RU33	POTEC_HUMAN	ANKRD26-like family B, member 2	77										skin(3)	3						CACGTTGCTCGTGCCGCTCCC	0.577		NA											9	210					6.32e-08	6.82e-08	1	0
KIAA1012	22878	broad.mit.edu	37	18	29450923	29450923	+	Silent	SNP	T	T	C			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr18:29450923T>C	uc002kxc.3	-	15	2587	c.2223A>G	c.(2221-2223)TCA>TCG	p.S741S	KIAA1012_uc002kxb.3_Silent_p.S687S|KIAA1012_uc002kxd.3_RNA	NM_014939	NP_055754	Q9Y2L5	TPPC8_HUMAN	hypothetical protein LOC22878	741					ER to Golgi vesicle-mediated transport	cis-Golgi network					0						TTGAATTATCTGAGTAACTGT	0.328		NA											9	9					0	0	0	0
CXXC1	30827	broad.mit.edu	37	18	47812911	47812911	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr18:47812911C>G	uc002leq.3	-	3	954	c.221G>C	c.(220-222)AGA>ACA	p.R74T	CXXC1_uc002lep.3_5'UTR|CXXC1_uc002ler.3_Missense_Mutation_p.R74T|CXXC1_uc010doy.2_Missense_Mutation_p.R74T|CXXC1_uc002les.2_Missense_Mutation_p.R74T	NM_014593	NP_055408	Q9P0U4	CXXC1_HUMAN	CXXC finger 1 (PHD domain) isoform 2	74	PHD-type.				histone H3-K4 methylation|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear speck|Set1C/COMPASS complex	protein binding|unmethylated CpG binding|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)	2						GCCCTCACCTCTGCACTCCCG	0.592		NA											20	43					0	0	0	0
TXNL1	9352	broad.mit.edu	37	18	54285302	54285302	+	Missense_Mutation	SNP	T	T	G			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr18:54285302T>G	uc002lgg.2	-	4	674	c.425A>C	c.(424-426)GAT>GCT	p.D142A	TXNL1_uc010xdz.1_RNA|TXNL1_uc002lgh.2_RNA|TXNL1_uc002lgi.2_Missense_Mutation_p.D142A|TXNL1_uc002lgj.1_Missense_Mutation_p.D142A	NM_004786	NP_004777	O43396	TXNL1_HUMAN	thioredoxin-like 1	142	PITH.				cell redox homeostasis|electron transport chain|glycerol ether metabolic process|transport	cytoplasm	electron carrier activity|protein disulfide oxidoreductase activity				0				READ - Rectum adenocarcinoma(59;0.193)|Colorectal(16;0.211)		TCCATGCTCATCACTTTCATT	0.353		NA											17	31					0	0	0	0
ZNF516	9658	broad.mit.edu	37	18	74154474	74154474	+	Silent	SNP	G	G	A			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr18:74154474G>A	uc010dqx.1	-	2	772	c.537C>T	c.(535-537)TGC>TGT	p.C179C	ZNF516_uc002lme.2_RNA	NM_014643	NP_055458	Q92618	ZN516_HUMAN	zinc finger protein 516	179	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Prostate(75;0.0869)|Esophageal squamous(42;0.129)		OV - Ovarian serous cystadenocarcinoma(15;7.64e-06)|BRCA - Breast invasive adenocarcinoma(31;0.238)		ACTGGCTCTTGCAGAAGGAGC	0.672		NA											4	19					0	0	0	0
NCLN	56926	broad.mit.edu	37	19	3192652	3192652	+	Silent	SNP	C	C	T			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr19:3192652C>T	uc002lxi.2	+	2	523	c.369C>T	c.(367-369)GTC>GTT	p.V123V	NCLN_uc002lxh.1_RNA	NM_020170	NP_064555	Q969V3	NCLN_HUMAN	nicalin precursor	123	Lumenal (Potential).				proteolysis|regulation of signal transduction	endoplasmic reticulum membrane|integral to membrane|nucleus	peptidase activity|protein binding				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.83e-113)|Epithelial(107;1.65e-111)|all cancers(105;1.53e-103)|BRCA - Breast invasive adenocarcinoma(158;0.00139)|STAD - Stomach adenocarcinoma(1328;0.18)		CCCAGGACGTCGTCCGGGTGA	0.592		NA											7	15					0	0	0	0
DAPK3	1613	broad.mit.edu	37	19	3964692	3964692	+	Silent	SNP	G	G	C			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr19:3964692G>C	uc002lzc.1	-	2	453	c.360C>G	c.(358-360)CTC>CTG	p.L120L	DAPK3_uc002lzb.1_5'Flank|DAPK3_uc002lzd.1_Silent_p.L120L	NM_001348	NP_001339	O43293	DAPK3_HUMAN	death-associated protein kinase 3	120	Protein kinase.				apoptosis|chromatin modification|induction of apoptosis|intracellular protein kinase cascade	cytoplasm|PML body	ATP binding|leucine zipper domain binding|protein serine/threonine kinase activity			central_nervous_system(3)|lung(2)|ovary(1)|large_intestine(1)	7		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00461)|STAD - Stomach adenocarcinoma(1328;0.18)		GGATCTGCTTGAGGAACTGGG	0.632		NA											27	66					0	0	0	0
PPAN	56342	broad.mit.edu	37	19	10221801	10221801	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr19:10221801G>A	uc002mmz.1	+	12	1488	c.1382G>A	c.(1381-1383)CGA>CAA	p.R461Q	PPAN-P2RY11_uc010xla.1_Intron|PPAN-P2RY11_uc002mna.2_Intron|P2RY11_uc002mnc.2_5'Flank|PPAN_uc002mnb.1_Missense_Mutation_p.R408Q	NM_020230	NP_064615	Q9NQ55	SSF1_HUMAN	peter pan homolog	461					RNA splicing	nucleolus	protein binding				0			OV - Ovarian serous cystadenocarcinoma(20;2.19e-08)|Epithelial(33;1.76e-05)|all cancers(31;3.54e-05)			GATGGTGGGCGAGGCCGGGGC	0.697		NA											4	7					0	0	0	0
LDLR	3949	broad.mit.edu	37	19	11233896	11233896	+	Silent	SNP	A	A	G			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr19:11233896A>G	uc002mqk.3	+	15	2355	c.2187A>G	c.(2185-2187)CTA>CTG	p.L729L	LDLR_uc010xlk.1_Silent_p.L729L|LDLR_uc010xll.1_Silent_p.L688L|LDLR_uc010xlm.1_Silent_p.L582L|LDLR_uc010xln.1_Silent_p.L551L|LDLR_uc010xlo.1_Silent_p.L561L	NM_000527	NP_000518	P01130	LDLR_HUMAN	low density lipoprotein receptor precursor	729	Clustered O-linked oligosaccharides.|Extracellular (Potential).				cholesterol homeostasis|cholesterol metabolic process|interspecies interaction between organisms|intestinal cholesterol absorption|low-density lipoprotein particle clearance|receptor-mediated endocytosis	clathrin-coated endocytic vesicle membrane|coated pit|early endosome|endosome membrane|external side of plasma membrane|integral to plasma membrane|low-density lipoprotein particle|lysosome	calcium ion binding|low-density lipoprotein receptor activity|protein binding|very-low-density lipoprotein particle receptor activity			ovary(2)|skin(2)	4		Lung NSC(9;0.000245)|Renal(1328;0.0007)|Hepatocellular(1079;0.0524)		GBM - Glioblastoma multiforme(1328;1.36e-05)|STAD - Stomach adenocarcinoma(1328;0.000766)|Lung(535;0.197)	Methyl aminolevulinate(DB00992)|Porfimer(DB00707)	CCGTCAGGCTAAAGGTCAGCT	0.612		NA											14	47					0	0	0	0
CCDC105	126402	broad.mit.edu	37	19	15132719	15132719	+	Silent	SNP	G	G	A			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr19:15132719G>A	uc002nae.2	+	6	1338	c.1239G>A	c.(1237-1239)GCG>GCA	p.A413A		NM_173482	NP_775753	Q8IYK2	CC105_HUMAN	coiled-coil domain containing 105	413					microtubule cytoskeleton organization	microtubule				ovary(1)	1						CGGAGGCTGCGCGCCTCGCAC	0.617		NA											26	16					0	0	0	0
CASP14	23581	broad.mit.edu	37	19	15164426	15164426	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr19:15164426G>C	uc010dzv.1	+	3	469	c.161G>C	c.(160-162)AGA>ACA	p.R54T	CASP14_uc002naf.2_Missense_Mutation_p.R54T	NM_012114	NP_036246	P31944	CASPE_HUMAN	caspase 14 precursor	54					apoptosis|cell differentiation|epidermis development|proteolysis	cytoplasm|nucleus	cysteine-type endopeptidase activity			skin(2)|ovary(1)|lung(1)	4						ACCATGAAAAGAGACCCCACT	0.537		NA											17	60					0	0	0	0
CPAMD8	27151	broad.mit.edu	37	19	17086829	17086829	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr19:17086829G>A	uc002nfb.2	-	16	2064	c.2032C>T	c.(2032-2034)CGG>TGG	p.R678W		NM_015692	NP_056507	Q8IZJ3	CPMD8_HUMAN	C3 and PZP-like, alpha-2-macroglobulin domain	631						extracellular space|plasma membrane	serine-type endopeptidase inhibitor activity			ovary(4)|breast(4)|large_intestine(3)|pancreas(1)|skin(1)	13						GGAGTCAGCCGGAACCCAGAC	0.602		NA											12	11					0	0	0	0
SF4	57794	broad.mit.edu	37	19	19431288	19431288	+	Silent	SNP	G	G	A			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr19:19431288G>A	uc002nmh.2	-	1	20	c.18C>T	c.(16-18)GAC>GAT	p.D6D	SF4_uc002nmi.2_5'UTR|SF4_uc002nmj.2_5'UTR|SF4_uc010xqr.1_RNA|SF4_uc010xqs.1_RNA|KIAA0892_uc002nmk.3_5'Flank	NM_172231	NP_757386	Q8IWZ8	SUGP1_HUMAN	splicing factor 4	6					nuclear mRNA splicing, via spliceosome	nucleoplasm|spliceosomal complex	RNA binding				0						CATCCCGGTTGTCCATCTTGA	0.632		NA											24	41					0	0	0	0
ZNF257	113835	broad.mit.edu	37	19	22271115	22271115	+	Missense_Mutation	SNP	T	T	A			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr19:22271115T>A	uc010ecx.2	+	4	732	c.563T>A	c.(562-564)CTA>CAA	p.L188Q	ZNF257_uc010ecy.2_Missense_Mutation_p.L156Q	NM_033468	NP_258429	Q9Y2Q1	ZN257_HUMAN	zinc finger protein 257	188	C2H2-type 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_lung(12;0.0961)|Lung NSC(12;0.103)				CTTTCACAACTAACTCGACAT	0.338		NA											4	18					0	0	0	0
ZNF780A	284323	broad.mit.edu	37	19	40582009	40582009	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr19:40582009C>G	uc002omy.2	-	6	565	c.340G>C	c.(340-342)GAG>CAG	p.E114Q	ZNF780A_uc002omw.3_Intron|ZNF780A_uc002omz.2_Missense_Mutation_p.E114Q|ZNF780A_uc010xvh.1_Missense_Mutation_p.E115Q	NM_001010880	NP_001010880	O75290	Z780A_HUMAN	zinc finger protein 780A isoform b	114					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_cancers(60;9.55e-06)|all_lung(34;1.17e-07)|Lung NSC(34;1.41e-07)|Ovarian(47;0.0925)					TAAAAGGCCTCAATGCCAAGA	0.328		NA											35	17					0	0	0	0
GRIK5	2901	broad.mit.edu	37	19	42557775	42557775	+	Silent	SNP	G	G	A			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr19:42557775G>A	uc002osj.1	-	10	1283	c.1248C>T	c.(1246-1248)ACC>ACT	p.T416T	GRIK5_uc010eib.1_Silent_p.T335T	NM_002088	NP_002079	Q16478	GRIK5_HUMAN	glutamate receptor KA2 precursor	416	Extracellular (Potential).					cell junction|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity				0		Prostate(69;0.059)			L-Glutamic Acid(DB00142)	TGACCACCAGGGTCTTGTTGG	0.622		NA											11	32					0	0	0	0
PSG8	440533	broad.mit.edu	37	19	43269720	43269720	+	Nonsense_Mutation	SNP	G	G	C			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr19:43269720G>C	uc002ouo.2	-	1	112	c.14C>G	c.(13-15)TCA>TGA	p.S5*	PSG3_uc002ouf.2_Intron|PSG1_uc002oug.1_Intron|PSG8_uc002oui.2_5'UTR|PSG8_uc002ouh.2_Nonsense_Mutation_p.S5*|PSG8_uc010ein.2_Nonsense_Mutation_p.S5*|PSG8_uc002ouj.3_Intron|PSG8_uc002ouk.3_Intron|PSG8_uc002oul.3_Intron|PSG8_uc002oum.3_Intron|PSG1_uc002oun.2_Intron|PSG8_uc002oup.3_Intron	NM_182707	NP_874366	Q9UQ74	PSG8_HUMAN	pregnancy specific beta-1-glycoprotein 8 isoform	5						extracellular region					0		Prostate(69;0.00899)				GGGAGGGGCTGAGAGGAGCCC	0.592		NA											18	62					0	0	0	0
MARK4	57787	broad.mit.edu	37	19	45783855	45783855	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr19:45783855C>T	uc002pbb.1	+	12	1144	c.1139C>T	c.(1138-1140)CCA>CTA	p.P380L	MARK4_uc002paz.1_3'UTR|MARK4_uc002pba.1_Missense_Mutation_p.P380L|MARK4_uc002pbc.1_Missense_Mutation_p.P246L			Q96L34	MARK4_HUMAN	RecName: Full=MAP/microtubule affinity-regulating kinase 4;          EC=2.7.11.1; AltName: Full=MAP/microtubule affinity-regulating kinase-like 1;	380					microtubule bundle formation|nervous system development|positive regulation of programmed cell death	centrosome|neuron projection	ATP binding|gamma-tubulin binding|microtubule binding|protein serine/threonine kinase activity|tau-protein kinase activity|ubiquitin binding			central_nervous_system(2)|large_intestine(1)	3		all_neural(266;0.224)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.0102)		CGGGGCGCCCCAGGGCTGGCC	0.677		NA											11	49					0	0	0	0
ZC3H4	23211	broad.mit.edu	37	19	47575952	47575952	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr19:47575952C>T	uc002pga.3	-	12	1497	c.1459G>A	c.(1459-1461)GAA>AAA	p.E487K	ZC3H4_uc002pgb.1_Intron	NM_015168	NP_055983	Q9UPT8	ZC3H4_HUMAN	zinc finger CCCH-type containing 4	487							nucleic acid binding|zinc ion binding			skin(4)|ovary(2)	6		all_cancers(25;3.3e-08)|all_epithelial(76;2.28e-06)|all_lung(116;7.86e-06)|Lung NSC(112;2.31e-05)|all_neural(266;0.026)|Ovarian(192;0.0392)|Breast(70;0.0889)		OV - Ovarian serous cystadenocarcinoma(262;5.76e-05)|all cancers(93;7.69e-05)|Epithelial(262;0.00354)|GBM - Glioblastoma multiforme(486;0.0372)		GCACCTGCTTCTGCATCATCG	0.587		NA											8	15					0	0	0	0
VRK3	51231	broad.mit.edu	37	19	50496192	50496192	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr19:50496192G>C	uc002prg.2	-	10	986	c.888C>G	c.(886-888)TTC>TTG	p.F296L	VRK3_uc002prh.1_Missense_Mutation_p.F296L|VRK3_uc002pri.1_Missense_Mutation_p.F246L|VRK3_uc010ens.2_Missense_Mutation_p.F296L|VRK3_uc010ybl.1_Missense_Mutation_p.F246L|VRK3_uc010ybm.1_Missense_Mutation_p.F65L|VRK3_uc002prj.1_Missense_Mutation_p.F246L|VRK3_uc002prk.1_Missense_Mutation_p.F296L|VRK3_uc010ent.1_Missense_Mutation_p.F52L|VRK3_uc002prl.2_Missense_Mutation_p.F296L|VRK3_uc010ybn.1_Missense_Mutation_p.S274C	NM_016440	NP_057524	Q8IV63	VRK3_HUMAN	vaccinia related kinase 3 isoform 1	296	Protein kinase.					nucleus	ATP binding|protein kinase activity			stomach(1)|skin(1)	2		all_neural(266;0.0459)|Ovarian(192;0.0481)		GBM - Glioblastoma multiforme(134;0.00166)|OV - Ovarian serous cystadenocarcinoma(262;0.00652)		TCTCATGGAGGAACTCCAGGG	0.522		NA											33	94					0	0	0	0
SIGLEC7	27036	broad.mit.edu	37	19	51649129	51649129	+	Missense_Mutation	SNP	A	A	C			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr19:51649129A>C	uc002pvv.1	+	4	847	c.778A>C	c.(778-780)AAC>CAC	p.N260H	SIGLEC7_uc002pvw.1_Missense_Mutation_p.N167H|SIGLEC7_uc010eoq.1_Intron|SIGLEC7_uc010eor.1_Intron	NM_014385	NP_055200	Q9Y286	SIGL7_HUMAN	sialic acid binding Ig-like lectin 7 isoform 1	260	Ig-like C2-type 2.|Extracellular (Potential).				cell adhesion	integral to plasma membrane	receptor activity|sugar binding			large_intestine(1)	1		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000836)|OV - Ovarian serous cystadenocarcinoma(262;0.00297)		AGCTCTGGGGAACAGCTCATC	0.517		NA											19	83					0	0	0	0
KIR3DL1	3811	broad.mit.edu	37	19	55378031	55378031	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr19:55378031G>A	uc002qhl.3	+	9	1276	c.1213G>A	c.(1213-1215)GTT>ATT	p.V405I	KIR3DL2_uc010esh.2_Missense_Mutation_p.V388I|KIR3DL2_uc002qho.3_Missense_Mutation_p.V405I			P43629	KI3L1_HUMAN	SubName: Full=KIR3DS1;	405	Cytoplasmic (Potential).				immune response|regulation of immune response	integral to plasma membrane	HLA-B specific inhibitory MHC class I receptor activity			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|skin(1)	5				GBM - Glioblastoma multiforme(193;0.0192)		GGATCACTGCGTTTTCATACA	0.512		NA											56	135					0	0	0	0
NLRP13	126204	broad.mit.edu	37	19	56413454	56413454	+	Silent	SNP	G	G	C			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr19:56413454G>C	uc010ygg.1	-	9	2761	c.2736C>G	c.(2734-2736)GTC>GTG	p.V912V		NM_176810	NP_789780	Q86W25	NAL13_HUMAN	NACHT, leucine rich repeat and PYD containing	912	LRR 4.						ATP binding			skin(4)|ovary(3)|pancreas(1)|lung(1)	9		Colorectal(82;3.48e-05)|Ovarian(87;0.0481)|Renal(1328;0.218)		GBM - Glioblastoma multiforme(193;0.0642)		ACAGGAACTTGACTCCCTCGT	0.552		NA											14	57					0	0	0	0
NLRP8	126205	broad.mit.edu	37	19	56481960	56481960	+	Missense_Mutation	SNP	A	A	C	rs143689901		TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr19:56481960A>C	uc002qmh.2	+	6	2503	c.2432A>C	c.(2431-2433)AAT>ACT	p.N811T	NLRP8_uc010etg.2_Missense_Mutation_p.N811T	NM_176811	NP_789781	Q86W28	NALP8_HUMAN	NLR family, pyrin domain containing 8	811						cytoplasm	ATP binding			ovary(4)|breast(3)|central_nervous_system(2)|skin(2)|large_intestine(1)|kidney(1)	13		Colorectal(82;0.000147)|Ovarian(87;0.17)		GBM - Glioblastoma multiforme(193;0.0695)		CTTGGCAATAATCTTCAAGGT	0.483		NA											23	177					0	0	0	0
ZNF814	730051	broad.mit.edu	37	19	58385546	58385546	+	Missense_Mutation	SNP	G	G	T			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr19:58385546G>T	uc002qqo.2	-	3	1484	c.1212C>A	c.(1210-1212)GAC>GAA	p.D404E	ZNF814_uc002qqk.2_Intron|ZNF814_uc010yhl.1_Intron	NM_001144989	NP_001138461	B7Z6K7	ZN814_HUMAN	zinc finger protein 814	404					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding				0						AATGTTTTTTGTCAGTGTGAA	0.393		NA											3	10					0.00909568	0.00929275	1	0
RSAD2	91543	broad.mit.edu	37	2	7018158	7018158	+	Missense_Mutation	SNP	A	A	G			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr2:7018158A>G	uc002qyp.1	+	1	363	c.227A>G	c.(226-228)AAC>AGC	p.N76S		NM_080657	NP_542388	Q8WXG1	RSAD2_HUMAN	radical S-adenosyl methionine domain containing	76					defense response to virus	endoplasmic reticulum membrane|Golgi apparatus	catalytic activity|iron-sulfur cluster binding|metal ion binding				0	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			OV - Ovarian serous cystadenocarcinoma(76;0.191)		ACCAGCGTCAACTATCACTTC	0.542		NA											23	41					0	0	0	0
ZNF513	130557	broad.mit.edu	37	2	27600461	27600461	+	Missense_Mutation	SNP	G	G	T			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr2:27600461G>T	uc002rkk.2	-	4	1777	c.1577C>A	c.(1576-1578)CCA>CAA	p.P526Q	ZNF513_uc002rkj.2_Missense_Mutation_p.P464Q	NM_144631	NP_653232	Q8N8E2	ZN513_HUMAN	zinc finger protein 513	526					regulation of transcription, DNA-dependent|response to stimulus|retina development in camera-type eye|transcription, DNA-dependent|visual perception	nucleus	transcription regulatory region DNA binding|zinc ion binding			ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CCCCAGGGCTGGTGGGCCCCG	0.622		NA											32	61					6.91e-12	7.64e-12	1	0
C2orf56	55471	broad.mit.edu	37	2	37459318	37459318	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr2:37459318C>G	uc002rqa.3	+	2	200	c.125C>G	c.(124-126)CCG>CGG	p.P42R	CEBPZ_uc002rpz.2_5'Flank|C2orf56_uc010ynj.1_RNA|C2orf56_uc002rqc.3_Missense_Mutation_p.P42R|C2orf56_uc010ynk.1_Missense_Mutation_p.P42R|C2orf56_uc010ynl.1_Missense_Mutation_p.P42R	NM_144736	NP_653337	Q7L592	MIDA_HUMAN	hypothetical protein LOC55471 isoform 1	42					mitochondrial respiratory chain complex I assembly	mitochondrion	enzyme binding|methyltransferase activity			central_nervous_system(1)	1		all_hematologic(82;0.21)				CCGGTGACGCCGATGCTGCGG	0.478		NA											6	111					0	0	0	0
THADA	63892	broad.mit.edu	37	2	43808911	43808911	+	Silent	SNP	C	C	T			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr2:43808911C>T	uc002rsw.3	-	8	1042	c.690G>A	c.(688-690)TTG>TTA	p.L230L	THADA_uc002rsx.3_Silent_p.L230L|THADA_uc002rsy.3_RNA|THADA_uc002rsz.2_5'UTR|THADA_uc002rta.2_5'UTR|THADA_uc002rtb.1_Silent_p.L230L|THADA_uc002rtc.3_Silent_p.L230L|THADA_uc002rtd.2_Silent_p.L230L	NM_001083953	NP_001077422	Q6YHU6	THADA_HUMAN	thyroid adenoma associated	230							binding			ovary(2)|skin(1)	3		Acute lymphoblastic leukemia(82;0.00361)|all_hematologic(82;0.00837)				AAATACTCAGCAATCCACACA	0.328		NA											8	72					0	0	0	0
TTC7A	57217	broad.mit.edu	37	2	47278982	47278983	+	Missense_Mutation	DNP	GC	GC	TT			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr2:47278982_47278983GC>TT	uc002rvo.2	+	18	2483_2484	c.2115_2116GC>TT	c.(2113-2118)CAGCTG>CATTTG	p.Q705H	TTC7A_uc002rvm.2_Missense_Mutation_p.Q671H|TTC7A_uc010fbb.2_Missense_Mutation_p.Q729H|TTC7A_uc010fbc.2_Missense_Mutation_p.Q351H|TTC7A_uc002rvp.2_Missense_Mutation_p.Q586H|TTC7A_uc002rvq.2_Missense_Mutation_p.Q445H|TTC7A_uc002rvr.2_Missense_Mutation_p.Q154H	NM_020458	NP_065191	Q9ULT0	TTC7A_HUMAN	tetratricopeptide repeat domain 7A	705							binding			breast(1)|skin(1)	2		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.18)	Lung(47;0.0792)|LUSC - Lung squamous cell carcinoma(58;0.114)			GCCCCATGCAGCTGTGGACCAC	0.658		NA											18	15					0	0	0	0
PTCD3	55037	broad.mit.edu	37	2	86361419	86361419	+	Missense_Mutation	SNP	T	T	G			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr2:86361419T>G	uc002sqw.2	+	20	1614	c.1548T>G	c.(1546-1548)AGT>AGG	p.S516R	PTCD3_uc002sqx.1_Missense_Mutation_p.S106R|SNORD94_uc010fgr.1_5'Flank	NM_017952	NP_060422	Q96EY7	PTCD3_HUMAN	pentatricopeptide repeat domain 3 precursor	516	PPR 9.					mitochondrion	protein binding			ovary(1)	1						TTCAAGATAGTAAAGAATATG	0.408		NA											12	26					0	0	0	0
SLC5A7	60482	broad.mit.edu	37	2	108626801	108626801	+	Silent	SNP	T	T	C			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr2:108626801T>C	uc002tdv.2	+	9	1503	c.1227T>C	c.(1225-1227)AGT>AGC	p.S409S	SLC5A7_uc010ywm.1_Silent_p.S162S|SLC5A7_uc010fjj.2_Silent_p.S409S|SLC5A7_uc010ywn.1_Silent_p.S296S	NM_021815	NP_068587	Q9GZV3	SC5A7_HUMAN	solute carrier family 5 (choline transporter),	409	Helical; (Potential).				acetylcholine biosynthetic process|neurotransmitter secretion	integral to membrane|plasma membrane	choline:sodium symporter activity			ovary(2)|central_nervous_system(1)|skin(1)	4					Choline(DB00122)	GGTACCTCAGTTCTGACCTTG	0.483		NA											28	40					0	0	0	0
MARCO	8685	broad.mit.edu	37	2	119727757	119727757	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr2:119727757G>C	uc002tln.1	+	3	399	c.267G>C	c.(265-267)GAG>GAC	p.E89D	MARCO_uc010yyf.1_Missense_Mutation_p.E11D	NM_006770	NP_006761	Q9UEW3	MARCO_HUMAN	macrophage receptor with collagenous structure	89	Extracellular (Potential).				cell surface receptor linked signaling pathway|innate immune response	collagen|integral to plasma membrane	pattern recognition receptor activity|scavenger receptor activity			ovary(3)|skin(2)|central_nervous_system(1)	6						TGGCGGCTGAGGACAGCCCGT	0.607		NA											22	32					0	0	0	0
GLI2	2736	broad.mit.edu	37	2	121732650	121732650	+	Missense_Mutation	SNP	A	A	G			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr2:121732650A>G	uc010flp.2	+	8	1363	c.1333A>G	c.(1333-1335)ACC>GCC	p.T445A	GLI2_uc002tmq.1_Missense_Mutation_p.T117A|GLI2_uc002tmr.1_Missense_Mutation_p.T100A|GLI2_uc002tmt.3_Missense_Mutation_p.T117A|GLI2_uc002tmu.3_Missense_Mutation_p.T100A|GLI2_uc010flo.1_Missense_Mutation_p.T303A|GLI2_uc002tmw.1_Missense_Mutation_p.T428A	NM_005270	NP_005261	P10070	GLI2_HUMAN	GLI-Kruppel family member GLI2	445	C2H2-type 1.				axon guidance|branching morphogenesis of a tube|cell proliferation|cerebellar cortex morphogenesis|developmental growth|embryonic digestive tract development|epidermal cell differentiation|floor plate formation|heart development|hindgut morphogenesis|kidney development|lung development|negative regulation of transcription from RNA polymerase II promoter|odontogenesis of dentine-containing tooth|osteoblast development|osteoblast differentiation|pituitary gland development|positive regulation of DNA replication|positive regulation of T cell differentiation in thymus|positive regulation of transcription from RNA polymerase II promoter|proximal/distal pattern formation|skeletal system development|smoothened signaling pathway involved in ventral spinal cord interneuron specification|spinal cord ventral commissure morphogenesis	nucleus|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|lung(2)|breast(1)|central_nervous_system(1)|pancreas(1)	13	Renal(3;0.0496)	Prostate(154;0.0623)				GGAAGACTGCACCAAGGAGTA	0.597		NA											9	50					0	0	0	0
LRP1B	53353	broad.mit.edu	37	2	141598641	141598641	+	Silent	SNP	G	G	A			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr2:141598641G>A	uc002tvj.1	-	30	5932	c.4960C>T	c.(4960-4962)CTA>TTA	p.L1654L		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	1654	Extracellular (Potential).|LDL-receptor class B 14.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		TCCACTGCTAGCCCTCTGATA	0.368		NA								TSP Lung(27;0.18)			27	45					0	0	0	0
GALNT5	11227	broad.mit.edu	37	2	158157196	158157196	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr2:158157196G>A	uc002tzg.2	+	7	2379	c.2124G>A	c.(2122-2124)ATG>ATA	p.M708I	GALNT5_uc010zci.1_RNA	NM_014568	NP_055383	Q7Z7M9	GALT5_HUMAN	N-acetylgalactosaminyltransferase 5	708	Catalytic subdomain B.|Lumenal (Potential).				glycosaminoglycan biosynthetic process	Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			breast(3)|skin(1)	4						AGGTGTGGATGTGTGGTGGTG	0.428		NA											9	65					0	0	0	0
BAZ2B	29994	broad.mit.edu	37	2	160206345	160206345	+	Silent	SNP	T	T	C			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr2:160206345T>C	uc002uao.2	-	28	5089	c.4737A>G	c.(4735-4737)TCA>TCG	p.S1579S	BAZ2B_uc002uap.2_Silent_p.S1543S	NM_013450	NP_038478	Q9UIF8	BAZ2B_HUMAN	bromodomain adjacent to zinc finger domain, 2B	1579					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(3)|skin(1)	4						AAGAAGCAGTTGACATATCGG	0.453		NA											46	75					0	0	0	0
CDCA7	83879	broad.mit.edu	37	2	174229611	174229611	+	Missense_Mutation	SNP	G	G	T			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr2:174229611G>T	uc002uid.1	+	5	682	c.551G>T	c.(550-552)AGG>ATG	p.R184M	CDCA7_uc002uic.1_Missense_Mutation_p.R263M|CDCA7_uc010zej.1_Missense_Mutation_p.R219M|CDCA7_uc010zek.1_Missense_Mutation_p.R142M	NM_145810	NP_665809	Q9BWT1	CDCA7_HUMAN	cell division cycle associated 7 isoform 2	184	Arg-rich.				regulation of cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(117;0.116)			ACCAGGTCAAGGTCCCGGATC	0.547		NA											10	42					1.77e-08	1.91e-08	1	0
TTN	7273	broad.mit.edu	37	2	179430407	179430407	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr2:179430407C>T	uc010zfg.1	-	275	72972	c.72748G>A	c.(72748-72750)GAA>AAA	p.E24250K	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.E17945K|TTN_uc010zfi.1_Missense_Mutation_p.E17878K|TTN_uc010zfj.1_Missense_Mutation_p.E17753K	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	25177							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GGCTGCATTTCAACAACGTAC	0.453		NA											21	131					0	0	0	0
TTN	7273	broad.mit.edu	37	2	179482556	179482556	+	Missense_Mutation	SNP	A	A	T			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr2:179482556A>T	uc010zfg.1	-	202	40042	c.39818T>A	c.(39817-39819)GTT>GAT	p.V13273D	TTN_uc010zfh.1_Missense_Mutation_p.V6968D|TTN_uc010zfi.1_Missense_Mutation_p.V6901D|TTN_uc010zfj.1_Missense_Mutation_p.V6776D	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	14200							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TGGTTTTCCAACTCCAATTCG	0.443		NA											45	75					0	0	0	0
ZNF385B	151126	broad.mit.edu	37	2	180348156	180348156	+	Missense_Mutation	SNP	C	C	A			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr2:180348156C>A	uc002unn.3	-	6	1117	c.513G>T	c.(511-513)CAG>CAT	p.Q171H	ZNF385B_uc002unj.2_Missense_Mutation_p.Q69H|ZNF385B_uc002unk.2_RNA|ZNF385B_uc002unl.2_Missense_Mutation_p.Q68H|ZNF385B_uc002unm.2_Missense_Mutation_p.Q95H	NM_152520	NP_689733	Q569K4	Z385B_HUMAN	zinc finger protein 385B isoform 1	171	Matrin-type 2.					nucleus	nucleic acid binding|zinc ion binding			ovary(1)	1			Epithelial(96;0.174)|OV - Ovarian serous cystadenocarcinoma(117;0.201)			GGGCCTCGGCCTGGCTCTACA	0.428		NA											30	34					2.81e-11	3.08e-11	1	0
STAT1	6772	broad.mit.edu	37	2	191872313	191872313	+	Silent	SNP	C	C	A			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr2:191872313C>A	uc002usj.2	-	5	736	c.348G>T	c.(346-348)CTG>CTT	p.L116L	STAT1_uc010fse.1_Silent_p.L116L|STAT1_uc002usk.2_Silent_p.L116L|STAT1_uc002usl.2_Silent_p.L118L|STAT1_uc010fsf.1_5'UTR	NM_007315	NP_009330	P42224	STAT1_HUMAN	signal transducer and activator of transcription	116					activation of caspase activity|I-kappaB kinase/NF-kappaB cascade|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway|tyrosine phosphorylation of STAT protein	cytosol|nucleolus|nucleoplasm	calcium ion binding|protein binding|RNA polymerase II core promoter sequence-specific DNA binding|RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity|signal transducer activity			lung(3)|breast(3)|central_nervous_system(2)|upper_aerodigestive_tract(1)|ovary(1)	10			OV - Ovarian serous cystadenocarcinoma(117;0.00434)|Epithelial(96;0.0555)|all cancers(119;0.141)		Fludarabine(DB01073)	GGGCGTTTTCCAGAATTTTCC	0.328		NA											38	44					2.19e-23	2.49e-23	1	0
RAPH1	65059	broad.mit.edu	37	2	204306102	204306102	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr2:204306102G>A	uc002vad.2	-	14	2036	c.1811C>T	c.(1810-1812)TCA>TTA	p.S604L		NM_213589	NP_998754	Q70E73	RAPH1_HUMAN	Ras association and pleckstrin homology domains	604					cell-matrix adhesion|signal transduction	cytoplasm|cytoskeleton|filopodium|lamellipodium|nucleus|plasma membrane				ovary(3)|breast(3)|central_nervous_system(2)|lung(1)|skin(1)	10						GGGCACAAGTGAAGTGTAGGG	0.378		NA											4	17					0	0	0	0
SPEG	10290	broad.mit.edu	37	2	220309817	220309817	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr2:220309817C>T	uc010fwg.2	+	3	749	c.749C>T	c.(748-750)TCC>TTC	p.S250F	SPEG_uc002vlm.2_RNA|SPEG_uc010fwh.1_Intron|SPEG_uc002vln.1_5'UTR	NM_005876	NP_005867	Q15772	SPEG_HUMAN	SPEG complex locus	250					muscle organ development|negative regulation of cell proliferation	nucleus	ATP binding|protein serine/threonine kinase activity			stomach(9)|ovary(4)|central_nervous_system(1)	14		Renal(207;0.0183)		Epithelial(149;4.5e-10)|all cancers(144;7.93e-08)|Lung(261;0.00639)|LUSC - Lung squamous cell carcinoma(224;0.00829)|READ - Rectum adenocarcinoma(5;0.163)		GATAGCCTTTCCGTGGCCAGT	0.652		NA											4	8					0	0	0	0
KIAA1486	57624	broad.mit.edu	37	2	226446903	226446903	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr2:226446903G>A	uc002voe.2	+	4	945	c.770G>A	c.(769-771)AGG>AAG	p.R257K	KIAA1486_uc010fxa.1_Intron|KIAA1486_uc002vof.1_Missense_Mutation_p.R27K	NM_020864	NP_065915	Q9P242	K1486_HUMAN	hypothetical protein LOC57624	257										ovary(2)|central_nervous_system(1)	3		Renal(207;0.0112)|all_lung(227;0.0477)|Lung NSC(271;0.0644)|all_hematologic(139;0.101)|Esophageal squamous(248;0.129)		Epithelial(121;6.73e-10)|all cancers(144;4.32e-07)|Lung(261;0.0161)|LUSC - Lung squamous cell carcinoma(224;0.0223)		AGAGACTTCAGGAAGGAGGAC	0.577		NA											50	69					0	0	0	0
COL4A3	1285	broad.mit.edu	37	2	228131135	228131135	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr2:228131135G>A	uc002vom.1	+	22	1480	c.1318G>A	c.(1318-1320)GAC>AAC	p.D440N	COL4A3_uc002von.1_Missense_Mutation_p.D440N|COL4A3_uc002voo.1_Missense_Mutation_p.D440N|COL4A3_uc002vop.1_Missense_Mutation_p.D440N|uc002voq.1_Intron|uc002vor.1_Intron	NM_000091	NP_000082	Q01955	CO4A3_HUMAN	alpha 3 type IV collagen isoform 1 precursor	440	Triple-helical region.				activation of caspase activity|axon guidance|blood circulation|cell adhesion|cell proliferation|cell surface receptor linked signaling pathway|glomerular basement membrane development|induction of apoptosis|negative regulation of angiogenesis|negative regulation of cell proliferation|sensory perception of sound	collagen type IV	extracellular matrix structural constituent|integrin binding|metalloendopeptidase inhibitor activity			skin(2)|ovary(1)	3		all_lung(227;0.00101)|Lung NSC(271;0.00278)|Renal(207;0.0112)|Ovarian(221;0.0129)|all_hematologic(139;0.211)|Esophageal squamous(248;0.247)		Epithelial(121;1.17e-46)|all cancers(144;6.87e-42)|Lung(261;0.0137)|LUSC - Lung squamous cell carcinoma(224;0.0187)		TTTTATAGGTGACATCGTTTT	0.393		NA											3	33					0	0	0	0
EIF4E2	9470	broad.mit.edu	37	2	233431923	233431923	+	Missense_Mutation	SNP	A	A	G			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr2:233431923A>G	uc002vta.2	+	6	742	c.664A>G	c.(664-666)AAA>GAA	p.K222E	EIF4E2_uc002vtb.1_Missense_Mutation_p.K222E|EIF4E2_uc010zmi.1_Missense_Mutation_p.K177E	NM_004846	NP_004837	O60573	IF4E2_HUMAN	eukaryotic translation initiation factor 4E	222	7-methylguanosine-containing mRNA cap binding (By similarity).				regulation of translation	cytoplasm|mRNA cap binding complex	RNA cap binding|translation initiation factor activity|ubiquitin protein ligase binding				0		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;2.3e-16)|BRCA - Breast invasive adenocarcinoma(100;0.000912)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.00942)		CGACAGCATCAAGTACGTGTT	0.507		NA											3	103					0	0	0	0
UGT1A6	54578	broad.mit.edu	37	2	234602466	234602466	+	Silent	SNP	C	C	T			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr2:234602466C>T	uc002vuv.3	+	1	955	c.816C>T	c.(814-816)GTC>GTT	p.V272V	UGT1A8_uc010zmv.1_Intron|UGT1A8_uc002vup.2_Intron|UGT1A10_uc002vuq.3_Intron|UGT1A10_uc002vur.2_Intron|UGT1A9_uc010zmw.1_Intron|UGT1A9_uc002vus.2_Intron|UGT1A7_uc010zmx.1_Intron|UGT1A7_uc002vut.2_Intron|UGT1A6_uc002vuu.2_Silent_p.V5V|UGT1A6_uc010zmy.1_Silent_p.V272V	NM_001072	NP_001063	P19224	UD16_HUMAN	UDP glycosyltransferase 1 family, polypeptide A6	272					xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	enzyme binding|glucuronosyltransferase activity|protein heterodimerization activity|protein homodimerization activity				0		Breast(86;0.000765)|all_lung(227;0.00267)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0328)|Lung NSC(271;0.0457)|Lung SC(224;0.128)		Epithelial(121;5.86e-18)|BRCA - Breast invasive adenocarcinoma(100;0.000384)|Lung(119;0.00306)|LUSC - Lung squamous cell carcinoma(224;0.00702)		CCAACATGGTCTTCATTGGAG	0.438		NA											243	375					0	0	0	0
STK25	10494	broad.mit.edu	37	2	242435884	242435884	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr2:242435884G>C	uc002wbm.2	-	10	1441	c.1170C>G	c.(1168-1170)TTC>TTG	p.F390L	STK25_uc002wbk.2_Missense_Mutation_p.F209L|STK25_uc002wbl.2_3'UTR|STK25_uc002wbn.2_Missense_Mutation_p.F390L|STK25_uc002wbo.2_Missense_Mutation_p.F313L|STK25_uc010zos.1_Missense_Mutation_p.F296L|STK25_uc010zot.1_Missense_Mutation_p.F316L|STK25_uc002wbp.2_Missense_Mutation_p.F390L|STK25_uc010fzo.2_Missense_Mutation_p.F313L|STK25_uc010zou.1_Missense_Mutation_p.F296L|STK25_uc010zov.1_Missense_Mutation_p.F296L	NM_006374	NP_006365	O00506	STK25_HUMAN	serine/threonine kinase 25	390					response to oxidative stress|signal transduction	Golgi apparatus	ATP binding|identical protein binding|metal ion binding|protein serine/threonine kinase activity				0		all_cancers(19;2.09e-34)|all_epithelial(40;2.09e-14)|Breast(86;0.000141)|Renal(207;0.0143)|all_lung(227;0.0344)|Ovarian(221;0.069)|Lung NSC(271;0.0886)|Esophageal squamous(248;0.131)|all_hematologic(139;0.182)|Melanoma(123;0.2)		Epithelial(32;8.24e-34)|all cancers(36;3.46e-31)|OV - Ovarian serous cystadenocarcinoma(60;3.6e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;1.1e-06)|Lung(119;0.000152)|LUSC - Lung squamous cell carcinoma(224;0.00154)|Colorectal(34;0.0129)|COAD - Colon adenocarcinoma(134;0.0839)		CGGCCAGGCTGAAGGCGTTCT	0.657		NA											13	59					0	0	0	0
ACSS1	84532	broad.mit.edu	37	20	24993469	24993469	+	Silent	SNP	G	G	A			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr20:24993469G>A	uc002wub.2	-	11	2564	c.1686C>T	c.(1684-1686)ACC>ACT	p.T562T	ACSS1_uc002wuc.2_Silent_p.T560T|ACSS1_uc010gdc.2_Silent_p.T357T|ACSS1_uc002wud.1_RNA|ACSS1_uc002wua.2_Silent_p.T479T	NM_032501	NP_115890	Q9NUB1	ACS2L_HUMAN	acyl-CoA synthetase short-chain family member 1	562					acetyl-CoA biosynthetic process|ethanol oxidation|xenobiotic metabolic process	mitochondrial matrix	acetate-CoA ligase activity|AMP binding|ATP binding|protein binding			ovary(1)|skin(1)	2					Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)	CAATCTCTGCGGTCCCCAGCC	0.597		NA											38	34					0	0	0	0
KIF3B	9371	broad.mit.edu	37	20	30898796	30898796	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr20:30898796G>A	uc002wxq.2	+	2	1383	c.1216G>A	c.(1216-1218)GAA>AAA	p.E406K	KIF3B_uc010ztv.1_Intron|KIF3B_uc010ztw.1_Intron	NM_004798	NP_004789	O15066	KIF3B_HUMAN	kinesin family member 3B	406	Poly-Glu.|Potential.				anterograde axon cargo transport|blood coagulation|determination of left/right symmetry|mitotic centrosome separation|plus-end-directed vesicle transport along microtubule|spindle assembly involved in mitosis	centrosome|cytosol|kinesin II complex|plus-end kinesin complex|spindle microtubule	ATP binding|plus-end-directed microtubule motor activity|Rho GTPase binding			central_nervous_system(3)|ovary(2)	5			UCEC - Uterine corpus endometrioid carcinoma (5;0.0241)			gggtgaggaggaaggggaTGA	0.418		NA											8	14					0	0	0	0
SAMHD1	25939	broad.mit.edu	37	20	35532577	35532577	+	Nonsense_Mutation	SNP	C	C	A			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr20:35532577C>A	uc002xgh.1	-	13	1616	c.1486G>T	c.(1486-1488)GAA>TAA	p.E496*	SAMHD1_uc010gft.1_RNA	NM_015474	NP_056289	Q9Y3Z3	SAMH1_HUMAN	SAM domain- and HD domain-containing protein 1	496					defense response to virus|innate immune response|regulation of innate immune response	nucleus	metal ion binding|phosphoric diester hydrolase activity				0		Myeloproliferative disorder(115;0.00878)				ATAAAATCTTCAGCCTTCAGT	0.353		NA											22	108					1.11e-09	1.21e-09	1	0
ZNF334	55713	broad.mit.edu	37	20	45140723	45140723	+	Missense_Mutation	SNP	G	G	T			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr20:45140723G>T	uc002xsc.2	-	2	203	c.19C>A	c.(19-21)CAG>AAG	p.Q7K	ZNF334_uc002xsd.2_5'UTR|ZNF334_uc010ghl.2_5'UTR	NM_018102	NP_060572	Q9HCZ1	ZN334_HUMAN	zinc finger protein 334 isoform a	7					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|pancreas(1)	2		Myeloproliferative disorder(115;0.0122)				CAACTTACCTGAAATTTTTTC	0.378		NA											20	26					7.88e-14	8.78e-14	1	0
ZNFX1	57169	broad.mit.edu	37	20	47887747	47887747	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr20:47887747C>T	uc002xui.2	-	3	849	c.602G>A	c.(601-603)CGC>CAC	p.R201H		NM_021035	NP_066363	Q9P2E3	ZNFX1_HUMAN	zinc finger, NFX1-type containing 1	201							metal ion binding			ovary(2)	2			BRCA - Breast invasive adenocarcinoma(12;0.00173)|COAD - Colon adenocarcinoma(4;0.14)|Colorectal(8;0.166)			AACACTCTGGCGATCCATTTT	0.453		NA											57	65					0	0	0	0
KCNB1	3745	broad.mit.edu	37	20	47990164	47990164	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr20:47990164C>G	uc002xur.1	-	2	2097	c.1933G>C	c.(1933-1935)GAT>CAT	p.D645H	KCNB1_uc002xus.1_Missense_Mutation_p.D645H	NM_004975	NP_004966	Q14721	KCNB1_HUMAN	potassium voltage-gated channel, Shab-related	645	Cytoplasmic (Potential).				energy reserve metabolic process|regulation of insulin secretion	voltage-gated potassium channel complex	protein binding|voltage-gated potassium channel activity			pancreas(1)|skin(1)	2			BRCA - Breast invasive adenocarcinoma(12;0.000405)|COAD - Colon adenocarcinoma(4;0.14)|Colorectal(8;0.166)			TGGCTGGCATCAGGGCTGGGG	0.567		NA											7	57					0	0	0	0
LAMA5	3911	broad.mit.edu	37	20	60884793	60884793	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr20:60884793G>C	uc002ycq.2	-	79	10994	c.10927C>G	c.(10927-10929)CTG>GTG	p.L3643V		NM_005560	NP_005551	O15230	LAMA5_HUMAN	laminin alpha 5 precursor	3643	Laminin G-like 5.				angiogenesis|cell proliferation|cell recognition|cytoskeleton organization|endothelial cell differentiation|focal adhesion assembly|integrin-mediated signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-11 complex	integrin binding			ovary(1)|pancreas(1)|skin(1)	3	Breast(26;1.57e-08)		BRCA - Breast invasive adenocarcinoma(19;4.36e-06)		Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	CCGAGGTACAGAGGGGCTGGG	0.607		NA											10	12					0	0	0	0
RWDD2B	10069	broad.mit.edu	37	21	30380432	30380432	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr21:30380432C>G	uc002yms.2	-	4	462	c.375G>C	c.(373-375)TTG>TTC	p.L125F	RWDD2B_uc002ymt.2_Missense_Mutation_p.L96F|RWDD2B_uc002ymu.2_RNA|RWDD2B_uc002ymv.2_Missense_Mutation_p.L45F	NM_016940	NP_058636	P57060	RWD2B_HUMAN	RWD domain containing 2B	125	RWD.										0						GGGATCTACTCAATAATACTG	0.358		NA											13	35					0	0	0	0
MICAL3	57553	broad.mit.edu	37	22	18387474	18387474	+	Silent	SNP	G	G	A			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr22:18387474G>A	uc002zng.3	-	3	749	c.396C>T	c.(394-396)TTC>TTT	p.F132F	MICAL3_uc011agl.1_Silent_p.F132F|MICAL3_uc002znh.2_Silent_p.F132F|MICAL3_uc002znj.1_5'Flank|MICAL3_uc002znk.1_Silent_p.F132F|MICAL3_uc002znl.1_5'UTR|MICAL3_uc010grf.2_Silent_p.F132F|MICAL3_uc011agm.1_Silent_p.F132F	NM_015241	NP_056056	Q7RTP6	MICA3_HUMAN	microtubule associated monoxygenase, calponin	132						cytoplasm|cytoskeleton	monooxygenase activity|zinc ion binding				0		all_epithelial(15;0.198)		Lung(27;0.0427)		CATGTATGGTGAATGGCCAGA	0.483		NA											32	91					0	0	0	0
MICAL3	57553	broad.mit.edu	37	22	18387600	18387600	+	Silent	SNP	G	G	A			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr22:18387600G>A	uc002zng.3	-	3	623	c.270C>T	c.(268-270)CTC>CTT	p.L90L	MICAL3_uc011agl.1_Silent_p.L90L|MICAL3_uc002znh.2_Silent_p.L90L|MICAL3_uc002znj.1_5'Flank|MICAL3_uc002znk.1_Silent_p.L90L|MICAL3_uc002znl.1_5'UTR|MICAL3_uc010grf.2_Silent_p.L90L|MICAL3_uc011agm.1_Silent_p.L90L	NM_015241	NP_056056	Q7RTP6	MICA3_HUMAN	microtubule associated monoxygenase, calponin	90	FAD (Potential).					cytoplasm|cytoskeleton	monooxygenase activity|zinc ion binding				0		all_epithelial(15;0.198)		Lung(27;0.0427)		CCCCAATGATGAGACACTGAA	0.507		NA											4	20					0	0	0	0
MICAL3	57553	broad.mit.edu	37	22	18389542	18389542	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr22:18389542G>C	uc002zng.3	-	2	390	c.37C>G	c.(37-39)CAT>GAT	p.H13D	MICAL3_uc011agl.1_Missense_Mutation_p.H13D|MICAL3_uc002znh.2_Missense_Mutation_p.H13D|MICAL3_uc002znk.1_Missense_Mutation_p.H13D|MICAL3_uc002znl.1_5'UTR|MICAL3_uc010grf.2_Missense_Mutation_p.H13D|MICAL3_uc011agm.1_Missense_Mutation_p.H13D	NM_015241	NP_056056	Q7RTP6	MICA3_HUMAN	microtubule associated monoxygenase, calponin	13						cytoplasm|cytoskeleton	monooxygenase activity|zinc ion binding				0		all_epithelial(15;0.198)		Lung(27;0.0427)		AAGAGGACATGAGCTGGGTTC	0.577		NA											18	63					0	0	0	0
C22orf15	150248	broad.mit.edu	37	22	24106898	24106898	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr22:24106898C>T	uc011aja.1	+	4	609	c.323C>T	c.(322-324)GCA>GTA	p.A108V	C22orf15_uc002zxv.1_3'UTR|C22orf15_uc002zxu.2_Missense_Mutation_p.A113V	NM_182520	NP_872326	Q8WYQ4	CV015_HUMAN	hypothetical protein LOC150248	108											0		Medulloblastoma(6;6.27e-05)|all_neural(6;0.00518)				CCAGAGCTGGCAGGTGAGTGT	0.587		NA											11	25					0	0	0	0
EIF3L	51386	broad.mit.edu	37	22	38270460	38270460	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr22:38270460C>T	uc003auf.2	+	9	922	c.835C>T	c.(835-837)CGC>TGC	p.R279C	EIF3L_uc003aue.1_Missense_Mutation_p.R279C|EIF3L_uc011ann.1_Missense_Mutation_p.R231C|EIF3L_uc003aug.2_Missense_Mutation_p.R171C|EIF3L_uc003auh.2_Missense_Mutation_p.R12C	NM_016091	NP_057175	Q9Y262	EIF3L_HUMAN	eukaryotic translation initiation factor 3	279						eukaryotic translation initiation factor 3 complex	protein binding|translation initiation factor activity			ovary(1)	1						CGGGCTTCTCCGCCTGCACTC	0.547		NA											44	19					0	0	0	0
ST13	6767	broad.mit.edu	37	22	41240914	41240914	+	Splice_Site	SNP	C	C	T			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr22:41240914C>T	uc003aze.2	-	4	388	c.245_splice	c.e4-1	p.E82_splice	ST13_uc011aow.1_Splice_Site_p.E72_splice	NM_003932	NP_003923	P50502	F10A1_HUMAN	heat shock 70kD protein binding protein								protein binding, bridging				0						TTATCAATTTCTGCCAAAGTC	0.388		NA											6	15					0	0	0	0
MPPED1	758	broad.mit.edu	37	22	43898630	43898630	+	Silent	SNP	C	C	A			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr22:43898630C>A	uc011apv.1	+	6	1078	c.855C>A	c.(853-855)ATC>ATA	p.I285I	MPPED1_uc011apw.1_Silent_p.I179I|MPPED1_uc011apx.1_Silent_p.I127I|MPPED1_uc011apy.1_Silent_p.I285I|MPPED1_uc011apz.1_Silent_p.I318I	NM_001044370	NP_001037835	O15442	MPPD1_HUMAN	metallophosphoesterase domain containing 1	285							hydrolase activity				0		all_neural(38;0.0244)|Ovarian(80;0.0694)				TTGGCCACATCCACGAAGGTC	0.612		NA											14	29					6.32e-08	6.82e-08	1	0
PLXNB2	23654	broad.mit.edu	37	22	50724681	50724681	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr22:50724681G>A	uc003bkv.3	-	9	1904	c.1798C>T	c.(1798-1800)CGA>TGA	p.R600*		NM_012401	NP_036533	O15031	PLXB2_HUMAN	plexin B2 precursor	600	Extracellular (Potential).				regulation of small GTPase mediated signal transduction	integral to membrane|intracellular	GTPase activator activity|protein binding|receptor activity			ovary(4)|central_nervous_system(1)|skin(1)	6		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		ATGTTGCCTCGTCTAAGGAGG	0.647		NA											59	20					0	0	0	0
EPHA3	2042	broad.mit.edu	37	3	89498433	89498433	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr3:89498433C>G	uc003dqy.2	+	14	2630	c.2405C>G	c.(2404-2406)ACG>AGG	p.T802R	EPHA3_uc010hon.1_RNA	NM_005233	NP_005224	P29320	EPHA3_HUMAN	ephrin receptor EphA3 isoform a precursor	802	Cytoplasmic (Potential).|Protein kinase.					extracellular region|integral to plasma membrane	ATP binding			lung(17)|ovary(7)|large_intestine(4)|central_nervous_system(2)|stomach(1)|skin(1)|pancreas(1)	33	all_cancers(8;0.0406)|Melanoma(1;0.00142)|all_epithelial(1;0.0612)	Lung NSC(201;0.0782)		LUSC - Lung squamous cell carcinoma(29;0.00344)|Lung(72;0.00942)		CGCAAGTTCACGTCAGCCAGC	0.438		NA								TSP Lung(6;0.00050)			50	65					0	0	0	0
OR5H14	403273	broad.mit.edu	37	3	97868318	97868318	+	Missense_Mutation	SNP	C	C	A			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr3:97868318C>A	uc003dsg.1	+	1	89	c.89C>A	c.(88-90)GCA>GAA	p.A30E		NM_001005514	NP_001005514	A6NHG9	O5H14_HUMAN	olfactory receptor, family 5, subfamily H,	30	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						CTGTTCCTGGCATTCTTGGTA	0.418		NA											80	153					2.37e-37	2.71e-37	1	0
CCDC80	151887	broad.mit.edu	37	3	112358039	112358039	+	Silent	SNP	C	C	T			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr3:112358039C>T	uc003dzf.2	-	2	932	c.714G>A	c.(712-714)CTG>CTA	p.L238L	CCDC80_uc011bhv.1_Silent_p.L238L|CCDC80_uc003dzg.2_Silent_p.L238L|CCDC80_uc003dzh.1_Silent_p.L238L	NM_199512	NP_955806	Q76M96	CCD80_HUMAN	steroid-sensitive protein 1 precursor	238										ovary(2)	2						GCGTCTTCTTCAGCAGCACCA	0.582		NA											20	108					0	0	0	0
DRD3	1814	broad.mit.edu	37	3	113850024	113850024	+	Missense_Mutation	SNP	T	T	G			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr3:113850024T>G	uc003ebd.2	-	7	1370	c.947A>C	c.(946-948)CAA>CCA	p.Q316P	DRD3_uc010hqn.1_Missense_Mutation_p.Q316P|DRD3_uc003ebb.1_Intron|DRD3_uc003ebc.1_Missense_Mutation_p.Q316P	NM_000796	NP_000787	P35462	DRD3_HUMAN	dopamine receptor D3 isoform a	316	Cytoplasmic.				activation of adenylate cyclase activity by dopamine receptor signaling pathway|arachidonic acid secretion|behavioral response to cocaine|cellular calcium ion homeostasis|circadian regulation of gene expression|G-protein coupled receptor internalization|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|locomotory behavior|musculoskeletal movement, spinal reflex action|negative regulation of blood pressure|negative regulation of oligodendrocyte differentiation|negative regulation of protein kinase B signaling cascade|negative regulation of protein secretion|positive regulation of dopamine receptor signaling pathway|positive regulation of mitosis|prepulse inhibition|regulation of dopamine secretion|response to drug|response to histamine|response to morphine|social behavior|visual learning	integral to plasma membrane	dopamine D3 receptor activity|drug binding			ovary(1)|pancreas(1)|central_nervous_system(1)|skin(1)	4					Apomorphine(DB00714)|Chlorprothixene(DB01239)|Cocaine(DB00907)|Methotrimeprazine(DB01403)|Olanzapine(DB00334)|Pramipexole(DB00413)|Ropinirole(DB00268)|Ziprasidone(DB00246)	TCCCCGAGGTTGCAGGGGCCC	0.443		NA											21	94					0	0	0	0
ZNF80	7634	broad.mit.edu	37	3	113955700	113955700	+	Silent	SNP	C	C	T			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr3:113955700C>T	uc010hqo.2	-	1	726	c.222G>A	c.(220-222)GTG>GTA	p.V74V	ZNF80_uc003ebf.2_RNA	NM_007136	NP_009067	P51504	ZNF80_HUMAN	zinc finger protein 80	74						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Lung NSC(201;0.0233)|all_neural(597;0.0837)				CATAAGGCTTCACCCCAGTGT	0.498		NA											8	23					0	0	0	0
STXBP5L	9515	broad.mit.edu	37	3	120941894	120941894	+	Missense_Mutation	SNP	C	C	A			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr3:120941894C>A	uc003eec.3	+	11	1141	c.1001C>A	c.(1000-1002)GCT>GAT	p.A334D	STXBP5L_uc011bji.1_Missense_Mutation_p.A334D	NM_014980	NP_055795	Q9Y2K9	STB5L_HUMAN	syntaxin binding protein 5-like	334	WD 6.				exocytosis|protein transport	cytoplasm|integral to membrane|plasma membrane				ovary(7)|skin(2)	9				GBM - Glioblastoma multiforme(114;0.0694)		TATGACAAAGCTTGTAGAAGA	0.368		NA											33	59					1.27e-14	1.41e-14	1	0
SGEF	26084	broad.mit.edu	37	3	153973168	153973168	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr3:153973168C>G	uc011bog.1	+	15	2733	c.2522C>G	c.(2521-2523)CCT>CGT	p.P841R	SGEF_uc011boh.1_3'UTR|SGEF_uc011boi.1_Missense_Mutation_p.P109R	NM_015595	NP_056410	Q96DR7	ARHGQ_HUMAN	Src homology 3 domain-containing guanine	841	SH3.				regulation of Rho protein signal transduction	intracellular|ruffle	Rho guanyl-nucleotide exchange factor activity			large_intestine(1)	1			LUSC - Lung squamous cell carcinoma(72;0.114)|Lung(72;0.173)			GGCTGGTTTCCTATGGAATGT	0.468		NA											16	63					0	0	0	0
NCAPG	64151	broad.mit.edu	37	4	17829921	17829921	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr4:17829921G>C	uc003gpp.2	+	12	1850	c.1674G>C	c.(1672-1674)CAG>CAC	p.Q558H	NCAPG_uc011bxj.1_Missense_Mutation_p.Q67H	NM_022346	NP_071741	Q9BPX3	CND3_HUMAN	chromosome condensation protein G	558					cell division|mitotic chromosome condensation	condensin complex|cytoplasm|nucleus	protein binding			large_intestine(1)	1				STAD - Stomach adenocarcinoma(129;0.18)		AAACATTGCAGAAATGTCTTA	0.348		NA											17	32					0	0	0	0
SLIT2	9353	broad.mit.edu	37	4	20525414	20525414	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr4:20525414C>T	uc003gpr.1	+	13	1366	c.1162C>T	c.(1162-1164)CGG>TGG	p.R388W	SLIT2_uc003gps.1_Missense_Mutation_p.R388W	NM_004787	NP_004778	O94813	SLIT2_HUMAN	slit homolog 2 precursor	388	LRR 10.				apoptosis involved in luteolysis|axon extension involved in axon guidance|branching morphogenesis of a tube|cell migration involved in sprouting angiogenesis|cellular response to heparin|cellular response to hormone stimulus|chemorepulsion involved in postnatal olfactory bulb interneuron migration|corticospinal neuron axon guidance through spinal cord|induction of negative chemotaxis|motor axon guidance|negative regulation of actin filament polymerization|negative regulation of cell growth|negative regulation of cellular response to growth factor stimulus|negative regulation of chemokine-mediated signaling pathway|negative regulation of endothelial cell migration|negative regulation of lamellipodium assembly|negative regulation of mononuclear cell migration|negative regulation of neutrophil chemotaxis|negative regulation of protein phosphorylation|negative regulation of retinal ganglion cell axon guidance|negative regulation of small GTPase mediated signal transduction|negative regulation of smooth muscle cell chemotaxis|negative regulation of vascular permeability|positive regulation of apoptosis|positive regulation of axonogenesis|response to cortisol stimulus|retinal ganglion cell axon guidance|Roundabout signaling pathway|ureteric bud development	cell surface|cytoplasm|extracellular space|plasma membrane	calcium ion binding|GTPase inhibitor activity|heparin binding|laminin-1 binding|protein homodimerization activity|proteoglycan binding|Roundabout binding			central_nervous_system(4)|skin(4)|ovary(3)	11						AAACTGCCTTCGGGTAGATGC	0.408		NA											23	78					0	0	0	0
KLF3	51274	broad.mit.edu	37	4	38696416	38696416	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr4:38696416G>A	uc003gth.3	+	5	1077	c.745G>A	c.(745-747)GAA>AAA	p.E249K		NM_016531	NP_057615	P57682	KLF3_HUMAN	Kruppel-like factor 3 (basic)	249	Pro-rich.				multicellular organismal development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|lung(1)	2						TTTACCTGTGGAATCCCCGGA	0.478		NA											11	81					0	0	0	0
EPHA5	2044	broad.mit.edu	37	4	66361186	66361187	+	Missense_Mutation	DNP	TG	TG	AT			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr4:66361186_66361187TG>AT	uc003hcy.2	-	4	1178_1179	c.985_986CA>AT	c.(985-987)CAT>ATT	p.H329I	EPHA5_uc003hcx.2_Missense_Mutation_p.H260I|EPHA5_uc003hcz.2_Missense_Mutation_p.H329I|EPHA5_uc011cah.1_Missense_Mutation_p.H329I|EPHA5_uc011cai.1_Missense_Mutation_p.H329I|EPHA5_uc003hda.2_Missense_Mutation_p.H329I	NM_004439	NP_004430	P54756	EPHA5_HUMAN	ephrin receptor EphA5 isoform a precursor	329	Extracellular (Potential).|Cys-rich.				cAMP-mediated signaling|neuron development	dendrite|external side of plasma membrane|integral to plasma membrane|neuronal cell body|perinuclear region of cytoplasm|rough endoplasmic reticulum	ATP binding|transmembrane-ephrin receptor activity			lung(19)|stomach(2)|ovary(2)|central_nervous_system(1)	24						AGCTTCCTCATGGGTATAACTG	0.465		NA								TSP Lung(17;0.13)			39	74					0	0	0	0
TMPRSS11D	9407	broad.mit.edu	37	4	68703947	68703947	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr4:68703947G>A	uc003hdq.2	-	5	483	c.418C>T	c.(418-420)CGA>TGA	p.R140*	LOC550112_uc003hdl.3_Intron|TMPRSS11D_uc011caj.1_Nonsense_Mutation_p.R23*	NM_004262	NP_004253	O60235	TM11D_HUMAN	transmembrane protease, serine 11D	140	SEA.|Extracellular (Potential).				proteolysis|respiratory gaseous exchange	extracellular region|integral to plasma membrane	serine-type endopeptidase activity			ovary(1)	1						AGCATTTGTCGTAAAACAGAC	0.333		NA											19	31					0	0	0	0
UGT2B7	7364	broad.mit.edu	37	4	69978401	69978401	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr4:69978401C>G	uc003heg.3	+	6	1583	c.1537C>G	c.(1537-1539)CTG>GTG	p.L513V	UGT2B7_uc010ihq.2_3'UTR	NM_001074	NP_001065	P16662	UD2B7_HUMAN	UDP glucuronosyltransferase 2B7 precursor	513					lipid metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			ovary(1)|skin(1)	2						AAAATGTTGTCTGTTTTGTTT	0.413		NA											37	46					0	0	0	0
UGT2B28	54490	broad.mit.edu	37	4	70152479	70152479	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr4:70152479G>C	uc003hej.2	+	3	882	c.880G>C	c.(880-882)GAA>CAA	p.E294Q	UGT2B28_uc010ihr.2_Missense_Mutation_p.E294Q	NM_053039	NP_444267	Q9BY64	UDB28_HUMAN	UDP glucuronosyltransferase 2 family,	294					xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			skin(1)	1					Flunitrazepam(DB01544)	GGAAATGGAGGAATTTGTACA	0.383		NA											57	104					0	0	0	0
RG9MTD2	93587	broad.mit.edu	37	4	100475021	100475021	+	Missense_Mutation	SNP	T	T	C			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr4:100475021T>C	uc003huy.2	-	6	879	c.566A>G	c.(565-567)GAT>GGT	p.D189G	RG9MTD2_uc003huz.3_Missense_Mutation_p.D189G|RG9MTD2_uc003hva.3_Missense_Mutation_p.D189G	NM_152292	NP_689505	Q8TBZ6	RG9D2_HUMAN	RNA (guanine-9-) methyltransferase domain	189							methyltransferase activity			ovary(2)|breast(1)	3				OV - Ovarian serous cystadenocarcinoma(123;1.7e-08)		ATTAGGTGAATCTGACGTAAG	0.338		NA											31	7					0	0	0	0
ANKRD50	57182	broad.mit.edu	37	4	125592804	125592804	+	Nonsense_Mutation	SNP	G	G	C			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr4:125592804G>C	uc003ifg.3	-	3	1894	c.1628C>G	c.(1627-1629)TCA>TGA	p.S543*	ANKRD50_uc011cgo.1_Nonsense_Mutation_p.S364*|ANKRD50_uc010inw.2_Nonsense_Mutation_p.S543*	NM_020337	NP_065070	Q9ULJ7	ANR50_HUMAN	ankyrin repeat domain 50	543										central_nervous_system(1)	1						TCTCCCATTTGAATCACACTG	0.398		NA											42	11					0	0	0	0
SNX25	83891	broad.mit.edu	37	4	186188282	186188282	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr4:186188282C>T	uc003ixh.2	+	5	761	c.572C>T	c.(571-573)TCT>TTT	p.S191F		NM_031953	NP_114159	Q9H3E2	SNX25_HUMAN	sorting nexin 25	191					cell communication|protein transport	endosome membrane	phosphatidylinositol binding|signal transducer activity			ovary(2)|breast(2)|pancreas(1)	5		all_lung(41;1.03e-13)|Lung NSC(41;2.5e-13)|Hepatocellular(41;0.00826)|Colorectal(36;0.00886)|Renal(120;0.00988)|Prostate(90;0.0235)|all_hematologic(60;0.0592)|all_neural(102;0.243)		all cancers(43;2.13e-24)|Epithelial(43;6.15e-22)|OV - Ovarian serous cystadenocarcinoma(60;5.6e-11)|BRCA - Breast invasive adenocarcinoma(30;0.00013)|Colorectal(24;0.000165)|GBM - Glioblastoma multiforme(59;0.000357)|COAD - Colon adenocarcinoma(29;0.000887)|STAD - Stomach adenocarcinoma(60;0.00118)|LUSC - Lung squamous cell carcinoma(40;0.0129)|READ - Rectum adenocarcinoma(43;0.228)		AACAGCAACTCTGATGTGGAG	0.438		NA											15	51					0	0	0	0
FAT1	2195	broad.mit.edu	37	4	187627830	187627830	+	Nonsense_Mutation	SNP	G	G	C			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr4:187627830G>C	uc003izf.2	-	2	3340	c.3152C>G	c.(3151-3153)TCA>TGA	p.S1051*	FAT1_uc010iso.1_Nonsense_Mutation_p.S1051*	NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor	1051	Extracellular (Potential).|Cadherin 9.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12						CATTACCAATGAACCAACAGG	0.483		NA								HNSCC(5;0.00058)			51	26					0	0	0	0
LPCAT1	79888	broad.mit.edu	37	5	1489929	1489929	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr5:1489929G>A	uc003jcm.2	-	4	655	c.538C>T	c.(538-540)CAG>TAG	p.Q180*		NM_024830	NP_079106	Q8NF37	PCAT1_HUMAN	lysophosphatidylcholine acyltransferase 1	180	Lumenal (Potential).				phospholipid biosynthetic process	endoplasmic reticulum membrane|Golgi membrane|integral to membrane	1-acylglycerophosphocholine O-acyltransferase activity|1-alkylglycerophosphocholine O-acetyltransferase activity|calcium ion binding			ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(19;0.0274)|all cancers(22;0.0534)	GBM - Glioblastoma multiforme(108;0.156)		CGAGAATCCTGGTCTGACCGG	0.557		NA											20	479					0	0	0	0
KIAA0947	23379	broad.mit.edu	37	5	5463028	5463028	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr5:5463028C>G	uc003jdm.3	+	13	3803	c.3581C>G	c.(3580-3582)TCT>TGT	p.S1194C		NM_015325	NP_056140	Q9Y2F5	K0947_HUMAN	hypothetical protein LOC23379	1194										ovary(1)|central_nervous_system(1)	2						GACTCTGTTTCTGAATGTTCT	0.378		NA											6	41					0	0	0	0
DNAH5	1767	broad.mit.edu	37	5	13901563	13901563	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr5:13901563G>A	uc003jfd.2	-	14	1892	c.1850C>T	c.(1849-1851)GCT>GTT	p.A617V		NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	617	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					CTGGTTTCGAGCCAGAGGAGG	0.478		NA							Kartagener_syndrome				18	79					0	0	0	0
CDH10	1008	broad.mit.edu	37	5	24535254	24535254	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr5:24535254C>T	uc003jgr.1	-	5	1113	c.781G>A	c.(781-783)GAT>AAT	p.D261N	CDH10_uc011cnu.1_RNA	NM_006727	NP_006718	Q9Y6N8	CAD10_HUMAN	cadherin 10, type 2 preproprotein	261	Cadherin 2.|Extracellular (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(6)|pancreas(4)|breast(2)	12				STAD - Stomach adenocarcinoma(35;0.0556)		TCATTGACATCTGTCAGCGTG	0.453		NA								HNSCC(23;0.051)			8	135					0	0	0	0
PDZD2	23037	broad.mit.edu	37	5	32037403	32037403	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr5:32037403C>G	uc003jhl.2	+	7	1862	c.1474C>G	c.(1474-1476)CCC>GCC	p.P492A	PDZD2_uc003jhm.2_Missense_Mutation_p.P492A|PDZD2_uc011cnx.1_Missense_Mutation_p.P318A	NM_178140	NP_835260	O15018	PDZD2_HUMAN	PDZ domain containing 2	492					cell adhesion	cell-cell junction|endoplasmic reticulum|extracellular region|nucleus				central_nervous_system(4)|ovary(2)|skin(2)|large_intestine(1)	9						CTTGGAAAGTCCCAAACAGGG	0.522		NA											6	78					0	0	0	0
RANBP3L	202151	broad.mit.edu	37	5	36251436	36251436	+	Missense_Mutation	SNP	G	G	T			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr5:36251436G>T	uc003jkh.2	-	13	1826	c.1333C>A	c.(1333-1335)CAA>AAA	p.Q445K	RANBP3L_uc011cow.1_Missense_Mutation_p.Q470K	NM_145000	NP_659437	Q86VV4	RNB3L_HUMAN	RAN binding protein 3-like isoform 2	445					intracellular transport					ovary(1)	1	all_lung(31;4.52e-05)		Epithelial(62;0.0543)|Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|all cancers(62;0.149)|Colorectal(62;0.202)			TTAGTGACTTGGATGAAATCA	0.353		NA											4	106					8.13e-05	8.55e-05	1	0
C5orf28	64417	broad.mit.edu	37	5	43453838	43453838	+	Silent	SNP	T	T	A			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr5:43453838T>A	uc003jny.2	-	2	377	c.234A>T	c.(232-234)GGA>GGT	p.G78G	C5orf28_uc003jnv.3_Silent_p.G78G|C5orf28_uc003jnx.2_Silent_p.G78G	NM_022483	NP_071928	Q0VDI3	CE028_HUMAN	hypothetical protein LOC64417	78	Helical; (Potential).					integral to membrane					0	Lung NSC(6;2.07e-05)					AAATGATTTCTCCAAAGTCAG	0.393		NA											33	128					0	0	0	0
CMYA5	202333	broad.mit.edu	37	5	79095241	79095241	+	Silent	SNP	G	G	A			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr5:79095241G>A	uc003kgc.2	+	13	12084	c.12012G>A	c.(12010-12012)GAG>GAA	p.E4004E		NM_153610	NP_705838	Q8N3K9	CMYA5_HUMAN	cardiomyopathy associated 5	4004	B30.2/SPRY.					perinuclear region of cytoplasm				ovary(6)|pancreas(2)|lung(1)	9		Lung NSC(167;0.00296)|all_lung(232;0.00327)|Ovarian(174;0.0262)		OV - Ovarian serous cystadenocarcinoma(54;9.85e-46)|Epithelial(54;3.38e-40)|all cancers(79;3.43e-35)		ATGTGACTGAGCGTCCAGCCA	0.443		NA											7	45					0	0	0	0
HAPLN1	1404	broad.mit.edu	37	5	82940335	82940335	+	Missense_Mutation	SNP	C	C	A			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr5:82940335C>A	uc003kim.2	-	3	693	c.622G>T	c.(622-624)GGC>TGC	p.G208C	HAPLN1_uc003kin.2_Missense_Mutation_p.G208C	NM_001884	NP_001875	P10915	HPLN1_HUMAN	hyaluronan and proteoglycan link protein 1	208	Link 1.				cell adhesion	proteinaceous extracellular matrix	hyaluronic acid binding			large_intestine(3)|ovary(1)|skin(1)	5		Lung NSC(167;0.0484)|all_lung(232;0.0522)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;7.82e-42)|Epithelial(54;5.88e-35)|all cancers(79;1.14e-29)		CTGAGCCAGCCGGCATTGCAC	0.622		NA											46	11					1.42e-22	1.6e-22	1	0
LOX	4015	broad.mit.edu	37	5	121411146	121411146	+	Silent	SNP	G	G	A			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr5:121411146G>A	uc003ksu.2	-	3	1206	c.831C>T	c.(829-831)TTC>TTT	p.F277F	LOX_uc010jcp.2_5'Flank|LOX_uc010jcq.2_5'UTR|LOX_uc011cwk.1_Silent_p.F47F|LOX_uc010jcr.2_5'UTR	NM_002317	NP_002308	P28300	LYOX_HUMAN	lysyl oxidase preproprotein	277	Lysyl-oxidase like.				protein modification process	extracellular space	copper ion binding|protein-lysine 6-oxidase activity			lung(1)	1		all_cancers(142;0.0124)|Prostate(80;0.0322)|Ovarian(225;0.0814)|Breast(839;0.143)	KIRC - Kidney renal clear cell carcinoma(527;0.206)	Epithelial(69;2.14e-11)|OV - Ovarian serous cystadenocarcinoma(64;7.87e-10)|all cancers(49;2.49e-09)|COAD - Colon adenocarcinoma(49;0.02)		GGCTGGGTAAGAAATCTGATG	0.453		NA											13	75					0	0	0	0
RAPGEF6	51735	broad.mit.edu	37	5	130897699	130897699	+	Missense_Mutation	SNP	A	A	T			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr5:130897699A>T	uc003kvn.1	-	5	529	c.323T>A	c.(322-324)CTT>CAT	p.L108H	RAPGEF6_uc003kvp.1_Missense_Mutation_p.L158H|RAPGEF6_uc003kvo.1_Missense_Mutation_p.L108H|RAPGEF6_uc010jdi.1_Missense_Mutation_p.L108H|RAPGEF6_uc010jdj.1_Missense_Mutation_p.L108H|RAPGEF6_uc003kvr.2_Missense_Mutation_p.L108H|RAPGEF6_uc011cxe.1_RNA|RAPGEF6_uc010jdk.2_Missense_Mutation_p.L108H	NM_016340	NP_057424	Q8TEU7	RPGF6_HUMAN	PDZ domain-containing guanine nucleotide	108					Ras protein signal transduction|regulation of GTPase activity|regulation of small GTPase mediated signal transduction	cytoplasm|plasma membrane	GTP-dependent protein binding|guanyl-nucleotide exchange factor activity|Ras GTPase binding			ovary(1)|lung(1)|central_nervous_system(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	Lung(113;0.0721)		CTCTAATACAAGACAATCACA	0.274		NA											63	12					0	0	0	0
PCDHA8	56140	broad.mit.edu	37	5	140222091	140222091	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr5:140222091C>G	uc003lhs.2	+	1	1185	c.1185C>G	c.(1183-1185)TTC>TTG	p.F395L	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhr.1_Missense_Mutation_p.F395L	NM_018911	NP_061734	Q9Y5H6	PCDA8_HUMAN	protocadherin alpha 8 isoform 1 precursor	395	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			upper_aerodigestive_tract(1)|ovary(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ATGTCCCCTTCAAGCTGGTGT	0.577		NA											43	192					0	0	0	0
HDAC3	8841	broad.mit.edu	37	5	141009429	141009429	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr5:141009429C>T	uc003llf.2	-	5	484	c.418G>A	c.(418-420)GAG>AAG	p.E140K	HDAC3_uc003lle.1_Missense_Mutation_p.E83K|HDAC3_uc010jgd.1_Missense_Mutation_p.E65K|HDAC3_uc010jge.1_Intron	NM_003883	NP_003874	O15379	HDAC3_HUMAN	histone deacetylase 3	140	Histone deacetylase.				anti-apoptosis|cellular lipid metabolic process|negative regulation of cell cycle|negative regulation of JNK cascade|negative regulation of transcription from RNA polymerase II promoter|nerve growth factor receptor signaling pathway|spindle assembly|transcription, DNA-dependent	cytoplasm|histone deacetylase complex|spindle microtubule|transcriptional repressor complex	histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|transcription corepressor activity|transcription factor binding			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)		Vorinostat(DB02546)	TCACTCACCTCAAACTTCTTG	0.517		NA											9	50					0	0	0	0
C5orf54	63920	broad.mit.edu	37	5	159821613	159821613	+	Silent	SNP	C	C	G			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr5:159821613C>G	uc003lye.1	-	2	1349	c.885G>C	c.(883-885)GTG>GTC	p.V295V	C5orf54_uc003lyf.1_Silent_p.V295V	NM_022090	NP_071373	Q8IZ13	CE054_HUMAN	transposon-derived Buster3 transposase-like	295										pancreas(1)	1						ttattaccctcaccacagtaa	0		NA											28	92					0	0	0	0
NSD1	64324	broad.mit.edu	37	5	176618931	176618931	+	Missense_Mutation	SNP	A	A	T			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr5:176618931A>T	uc003mfr.3	+	3	1112	c.974A>T	c.(973-975)GAT>GTT	p.D325V	NSD1_uc003mft.3_Missense_Mutation_p.D56V|NSD1_uc003mfs.1_Intron|NSD1_uc011dfx.1_5'UTR|NSD1_uc003mfp.2_Missense_Mutation_p.D325V	NM_022455	NP_071900	Q96L73	NSD1_HUMAN	nuclear receptor binding SET domain protein 1	325	PWWP 1.				negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	androgen receptor binding|chromatin binding|estrogen receptor binding|histone methyltransferase activity (H3-K36 specific)|histone methyltransferase activity (H4-K20 specific)|ligand-dependent nuclear receptor binding|retinoid X receptor binding|thyroid hormone receptor binding|transcription corepressor activity|zinc ion binding			ovary(2)|kidney(1)	3	all_cancers(89;1.57e-05)|Renal(175;0.000269)|Lung NSC(126;0.00111)|all_lung(126;0.002)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)|Epithelial(233;0.198)	Kidney(146;0.235)		GAAGTTGGAGATCTCATCTGG	0.388		NA	T	NUP98	AML		Sotos Syndrome		Beckwith-Wiedemann_syndrome|Sotos_syndrome|Weaver_syndrome	HNSCC(47;0.14)			41	16					0	0	0	0
C6orf195	154386	broad.mit.edu	37	6	2623874	2623874	+	Silent	SNP	G	G	A			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr6:2623874G>A	uc003mtw.2	-	3	1168	c.183C>T	c.(181-183)CCC>CCT	p.P61P		NM_152554	NP_689767	Q96MT4	CF195_HUMAN	hypothetical protein LOC154386	61											0	Ovarian(93;0.0412)	all_hematologic(90;0.0895)				GGCCGGACCCGGGAGGGGAGA	0.632		NA											46	73					0	0	0	0
PAK1IP1	55003	broad.mit.edu	37	6	10707670	10707670	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr6:10707670G>C	uc003mzg.2	+	8	794	c.763G>C	c.(763-765)GAA>CAA	p.E255Q		NM_017906	NP_060376	Q9NWT1	PK1IP_HUMAN	PAK1 interacting protein 1	255	WD 5.				negative regulation of signal transduction	nucleolus|plasma membrane					0	Ovarian(93;0.107)|Breast(50;0.137)	all_hematologic(90;0.117)				GTTCAGTTTTGAAATTCCAGA	0.333		NA											22	90					0	0	0	0
HIST1H1C	3006	broad.mit.edu	37	6	26056153	26056153	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr6:26056153C>G	uc003nfw.2	-	1	547	c.504G>C	c.(502-504)AAG>AAC	p.K168N		NM_005319	NP_005310	P16403	H12_HUMAN	histone cluster 1, H1c	168					nucleosome assembly	nucleosome|nucleus	DNA binding			ovary(3)|skin(2)	5						TAGCCACTTTCTTGGTTACAG	0.572		NA											61	27					0	0	0	0
HIST1H2BK	85236	broad.mit.edu	37	6	27114365	27114365	+	Silent	SNP	G	G	A			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr6:27114365G>A	uc003nix.1	-	1	255	c.213C>T	c.(211-213)TTC>TTT	p.F71F	HIST1H2AH_uc003niz.2_5'Flank|hsa-mir-3143|MI0014167_5'Flank	NM_080593	NP_542160	O60814	H2B1K_HUMAN	histone cluster 1, H2bk	71					defense response to bacterium|nucleosome assembly	nucleosome|nucleus	DNA binding				0						CGATGCGTTCGAAGATGTCGT	0.602		NA											86	35					0	0	0	0
TTBK1	84630	broad.mit.edu	37	6	43230556	43230556	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr6:43230556C>T	uc003ouq.1	+	13	1733	c.1454C>T	c.(1453-1455)TCG>TTG	p.S485L	TTBK1_uc011dvg.1_Missense_Mutation_p.S8L	NM_032538	NP_115927	Q5TCY1	TTBK1_HUMAN	tau tubulin kinase 1	485						cell junction|cytoplasm|nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			lung(4)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	9			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0125)|OV - Ovarian serous cystadenocarcinoma(102;0.0399)			GGCTCGCCCTCGCGCCAGGCC	0.677		NA											5	4					0	0	0	0
POPDC3	64208	broad.mit.edu	37	6	105606561	105606561	+	Silent	SNP	G	G	A			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr6:105606561G>A	uc003prb.2	-	4	1062	c.660C>T	c.(658-660)CTC>CTT	p.L220L	uc003pqz.2_Intron|POPDC3_uc003pra.2_RNA	NM_022361	NP_071756	Q9HBV1	POPD3_HUMAN	popeye protein 3	220						integral to membrane				skin(3)|ovary(2)	5		all_cancers(87;4.87e-05)|Acute lymphoblastic leukemia(125;1.9e-08)|all_hematologic(75;9.25e-07)|all_epithelial(87;0.0157)|Colorectal(196;0.202)|Lung NSC(302;0.238)				GCTGAGCAAAGAGCAGATATA	0.408		NA											46	89					0	0	0	0
PRDM1	639	broad.mit.edu	37	6	106547390	106547390	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr6:106547390C>G	uc003prd.2	+	4	861	c.627C>G	c.(625-627)CAC>CAG	p.H209Q	PRDM1_uc003pre.2_Missense_Mutation_p.H75Q	NM_001198	NP_001189	O75626	PRDM1_HUMAN	PR domain containing 1, with ZNF domain isoform	209					negative regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(54)|ovary(1)|skin(1)	56	Breast(9;0.022)	all_cancers(87;2.2e-31)|all_epithelial(87;2.03e-21)|Acute lymphoblastic leukemia(125;4.99e-11)|all_lung(197;7.55e-09)|all_hematologic(75;5.82e-08)|Lung NSC(302;1.28e-06)|Colorectal(196;0.0112)|Ovarian(999;0.0365)		all cancers(137;1.83e-46)|Epithelial(106;5.59e-35)|OV - Ovarian serous cystadenocarcinoma(136;1.99e-20)|GBM - Glioblastoma multiforme(226;3.72e-11)|BRCA - Breast invasive adenocarcinoma(108;1.38e-05)		AAAGGCTTCACTACCCTTATC	0.443		NA	D|N|Mis|F|S		DLBCL								16	5					0	0	0	0
SERAC1	84947	broad.mit.edu	37	6	158540196	158540196	+	Silent	SNP	G	G	A			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr6:158540196G>A	uc003qrc.2	-	12	1315	c.1173C>T	c.(1171-1173)CCC>CCT	p.P391P	SERAC1_uc003qrb.2_Silent_p.P119P	NM_032861	NP_116250	Q96JX3	SRAC1_HUMAN	serine active site containing 1	391					GPI anchor metabolic process|intracellular protein transport	integral to membrane|intrinsic to endoplasmic reticulum membrane	binding|hydrolase activity, acting on ester bonds				0		Breast(66;0.00519)|Ovarian(120;0.123)|Prostate(117;0.178)		OV - Ovarian serous cystadenocarcinoma(65;1.37e-18)|BRCA - Breast invasive adenocarcinoma(81;3.19e-05)		CTGCTTTAATGGGCTGACTAA	0.423		NA											2	5					0	0	0	0
QKI	9444	broad.mit.edu	37	6	163984469	163984469	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr6:163984469C>G	uc003qui.2	+	6	1203	c.652C>G	c.(652-654)CTT>GTT	p.L218V	QKI_uc003que.2_Missense_Mutation_p.L218V|QKI_uc003quf.2_Missense_Mutation_p.L218V|QKI_uc003qug.2_Missense_Mutation_p.L218V|QKI_uc003quh.2_Intron|QKI_uc003quj.2_Intron	NM_006775	NP_006766	Q96PU8	QKI_HUMAN	quaking homolog, KH domain RNA binding isoform	218					mRNA processing|mRNA transport|regulation of translation|RNA splicing	cytoplasm|nucleus|plasma membrane	RNA binding|SH3 domain binding			large_intestine(1)|ovary(1)	2		Breast(66;5e-05)|Prostate(117;0.0235)|all_neural(5;0.0416)|Ovarian(120;0.0448)|Glioma(2;0.203)		all cancers(1;4.4e-46)|OV - Ovarian serous cystadenocarcinoma(33;6.91e-23)|GBM - Glioblastoma multiforme(1;2.94e-19)|BRCA - Breast invasive adenocarcinoma(81;1.49e-06)|Kidney(3;0.000199)|KIRC - Kidney renal clear cell carcinoma(3;0.000234)		TGCCTTTTCTCTTGCAGCAAC	0.498		NA											3	20					0	0	0	0
EIF3B	8662	broad.mit.edu	37	7	2412331	2412331	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr7:2412331G>A	uc003slx.2	+	12	1794	c.1711G>A	c.(1711-1713)GAA>AAA	p.E571K	EIF3B_uc003sly.2_Missense_Mutation_p.E571K|EIF3B_uc003sma.2_Missense_Mutation_p.E299K	NM_003751	NP_003742	P55884	EIF3B_HUMAN	eukaryotic translation initiation factor 3,	571	WD 4.				regulation of translational initiation	cytosol|eukaryotic translation initiation factor 3 complex	nucleotide binding|protein complex scaffold|translation initiation factor activity				0		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0833)|OV - Ovarian serous cystadenocarcinoma(56;7.76e-14)		CTTTGCCTGGGAACCAAATGG	0.438		NA											11	24					0	0	0	0
LFNG	3955	broad.mit.edu	37	7	2566545	2566545	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr7:2566545G>A	uc003smf.2	+	7	1080	c.1063G>A	c.(1063-1065)GAC>AAC	p.D355N	LFNG_uc003smg.2_Missense_Mutation_p.D355N	NM_001040167	NP_001035257	Q8NES3	LFNG_HUMAN	lunatic fringe isoform a	355	Lumenal (Potential).				organ morphogenesis	extracellular region|integral to Golgi membrane	O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity				0		Ovarian(82;0.0112)		OV - Ovarian serous cystadenocarcinoma(56;2.54e-14)		GGTGGAGGCCGACCCATCCAG	0.647		NA											5	17					0	0	0	0
THSD7A	221981	broad.mit.edu	37	7	11676325	11676325	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr7:11676325C>T	uc003ssf.3	-	2	706	c.454G>A	c.(454-456)GGT>AGT	p.G152S		NM_015204	NP_056019	Q9UPZ6	THS7A_HUMAN	thrombospondin, type I, domain containing 7A	152	Extracellular (Potential).					integral to membrane				ovary(3)	3				UCEC - Uterine corpus endometrioid carcinoma (126;0.163)		ACCTGAATACCTTCTTCCCCC	0.488		NA								HNSCC(18;0.044)			16	26					0	0	0	0
ABCB5	340273	broad.mit.edu	37	7	20739693	20739693	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr7:20739693G>C	uc003suw.3	+	10	1483	c.937G>C	c.(937-939)GGC>CGC	p.G313R	ABCB5_uc010kuh.2_Missense_Mutation_p.G758R	NM_178559	NP_848654	Q2M3G0	ABCB5_HUMAN	ATP-binding cassette, sub-family B, member 5	313	Extracellular (Potential).|ABC transmembrane type-1.				regulation of membrane potential	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus	ATP binding|ATPase activity, coupled to transmembrane movement of substances|efflux transmembrane transporter activity			skin(2)|large_intestine(1)|haematopoietic_and_lymphoid_tissue(1)|ovary(1)|pancreas(1)	6						ATTATTTTACGGCAGAGCAGG	0.303		NA											26	59					0	0	0	0
DNAH11	8701	broad.mit.edu	37	7	21678648	21678648	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr7:21678648C>G	uc003svc.2	+	28	4955	c.4924C>G	c.(4924-4926)CTT>GTT	p.L1642V		NM_003777	NP_003768	Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	1642	Stem (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(8)|large_intestine(3)|pancreas(3)|central_nervous_system(1)	15						TGCTGATTTACTTGACATTCT	0.398		NA							Kartagener_syndrome				9	48					0	0	0	0
GLI3	2737	broad.mit.edu	37	7	42079708	42079708	+	Silent	SNP	C	C	T			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr7:42079708C>T	uc011kbh.1	-	7	1048	c.957G>A	c.(955-957)ACG>ACA	p.T319T	GLI3_uc011kbg.1_Silent_p.T260T	NM_000168	NP_000159	P10071	GLI3_HUMAN	GLI-Kruppel family member GLI3	319					negative regulation of alpha-beta T cell differentiation|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of smoothened signaling pathway|negative regulation of transcription from RNA polymerase II promoter|negative thymic T cell selection|positive regulation of alpha-beta T cell differentiation|positive regulation of transcription from RNA polymerase II promoter|thymocyte apoptosis	cilium|cytosol|nucleolus	beta-catenin binding|histone acetyltransferase binding|histone deacetylase binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(11)|ovary(3)|large_intestine(2)|central_nervous_system(1)|kidney(1)|pancreas(1)	19						TATTGAGAATCGTGACCAAGG	0.468		NA							Greig_Cephalopolysyndactyly|Pallister-Hall_syndrome				7	52					0	0	0	0
POLD2	5425	broad.mit.edu	37	7	44157600	44157600	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr7:44157600C>T	uc010kxz.2	-	4	934	c.284G>A	c.(283-285)GGC>GAC	p.G95D	POLD2_uc003tke.3_Missense_Mutation_p.G95D|POLD2_uc010kya.2_Missense_Mutation_p.G95D|POLD2_uc003tkf.3_Missense_Mutation_p.G95D	NM_006230	NP_006221	P49005	DPOD2_HUMAN	DNA-directed DNA polymerase delta 2	95					base-excision repair|DNA strand elongation involved in DNA replication|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	nucleoplasm	DNA binding|DNA-directed DNA polymerase activity|protein binding			ovary(2)	2						GAACAGAGTGCCCACCACACA	0.617		NA											3	59					0	0	0	0
TNS3	64759	broad.mit.edu	37	7	47476871	47476871	+	Missense_Mutation	SNP	A	A	G			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr7:47476871A>G	uc003tnv.2	-	7	558	c.191T>C	c.(190-192)CTT>CCT	p.L64P	TNS3_uc003tnw.2_Missense_Mutation_p.L64P|TNS3_uc010kyo.1_Missense_Mutation_p.L64P	NM_022748	NP_073585	Q68CZ2	TENS3_HUMAN	tensin 3	64	Phosphatase tensin-type.					focal adhesion	protein binding			ovary(4)	4						CTTTGGGTTAAGCTTCGTAAG	0.274		NA											21	32					0	0	0	0
SUN3	256979	broad.mit.edu	37	7	48045610	48045610	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr7:48045610C>G	uc003tof.2	-	7	630	c.533G>C	c.(532-534)AGA>ACA	p.R178T	SUN3_uc010kyq.2_Missense_Mutation_p.R78T|SUN3_uc003tog.2_Missense_Mutation_p.R178T|SUN3_uc011kcf.1_Missense_Mutation_p.R166T	NM_152782	NP_689995	Q8TAQ9	SUN3_HUMAN	Sad1 and UNC84 domain containing 1	178						integral to membrane				central_nervous_system(1)	1						TTGGTCTTCTCTCAACTTTTT	0.358		NA											7	33					0	0	0	0
HGF	3082	broad.mit.edu	37	7	81355326	81355326	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr7:81355326G>A	uc003uhl.2	-	9	1213	c.1048C>T	c.(1048-1050)CGA>TGA	p.R350*	HGF_uc003uhm.2_Nonsense_Mutation_p.R345*	NM_000601	NP_000592	P14210	HGF_HUMAN	hepatocyte growth factor isoform 1	350	Kringle 3.				epithelial to mesenchymal transition|mitosis|platelet activation|platelet degranulation|proteolysis|regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling	platelet alpha granule lumen	growth factor activity|serine-type endopeptidase activity			ovary(2)|central_nervous_system(2)	4						TAATTTTCTCGTAGGTCCCTA	0.418		NA											19	47					0	0	0	0
VGF	7425	broad.mit.edu	37	7	100806475	100806475	+	Silent	SNP	G	G	A			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr7:100806475G>A	uc003uxx.3	-	2	1868	c.1650C>T	c.(1648-1650)ATC>ATT	p.I550I		NM_003378	NP_003369	O15240	VGF_HUMAN	VGF nerve growth factor inducible precursor	550					response to cAMP	extracellular space|transport vesicle	growth factor activity				0	Lung NSC(181;0.168)|all_lung(186;0.215)					TCCGCGGCCGGATGTAGTTGG	0.721		NA											7	53					0	0	0	0
SLC26A5	375611	broad.mit.edu	37	7	103053458	103053458	+	Missense_Mutation	SNP	T	T	G			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr7:103053458T>G	uc003vbz.2	-	5	630	c.394A>C	c.(394-396)ATA>CTA	p.I132L	SLC26A5_uc003vbt.1_Missense_Mutation_p.I132L|SLC26A5_uc003vbu.1_Missense_Mutation_p.I132L|SLC26A5_uc003vbv.1_Missense_Mutation_p.I132L|SLC26A5_uc003vbw.2_RNA|SLC26A5_uc003vbx.2_Missense_Mutation_p.I132L|SLC26A5_uc003vby.2_RNA|SLC26A5_uc010liy.2_RNA	NM_198999	NP_945350	P58743	S26A5_HUMAN	prestin isoform a	132	Helical; Name=3; (Potential).				regulation of cell shape|sensory perception of sound	integral to membrane	secondary active sulfate transmembrane transporter activity			ovary(1)	1						CCTATGGATATGTGTCTGGAG	0.373		NA											12	42					0	0	0	0
PNPLA8	50640	broad.mit.edu	37	7	108154982	108154982	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr7:108154982C>G	uc003vff.1	-	4	1361	c.954G>C	c.(952-954)AAG>AAC	p.K318N	PNPLA8_uc003vfg.1_RNA|PNPLA8_uc003vfh.1_Missense_Mutation_p.K318N|PNPLA8_uc003vfi.1_Missense_Mutation_p.K218N|PNPLA8_uc003vfj.1_Missense_Mutation_p.K318N|PNPLA8_uc003vfk.1_Missense_Mutation_p.K218N	NM_015723	NP_056538	Q9NP80	PLPL8_HUMAN	patatin-like phospholipase domain containing 8	318					fatty acid metabolic process|lipid catabolic process	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|membrane fraction|perinuclear region of cytoplasm|peroxisomal membrane	ATP binding|calcium-independent phospholipase A2 activity|lysophospholipase activity			breast(2)	2						CTGACTGACTCTTTGAATCAT	0.413		NA											30	156					0	0	0	0
C7orf60	154743	broad.mit.edu	37	7	112461999	112461999	+	Missense_Mutation	SNP	T	T	C			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr7:112461999T>C	uc003vgo.1	-	5	1145	c.1018A>G	c.(1018-1020)ATT>GTT	p.I340V	C7orf60_uc011kms.1_Missense_Mutation_p.I366V	NM_152556	NP_689769	Q1RMZ1	CG060_HUMAN	hypothetical protein LOC154743	340										ovary(2)|skin(1)	3						TCTTGAGGAATATATAACATT	0.294		NA											4	37					0	0	0	0
ING3	54556	broad.mit.edu	37	7	120613295	120613295	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr7:120613295G>C	uc003vjn.2	+	11	1272	c.1138G>C	c.(1138-1140)GAT>CAT	p.D380H	ING3_uc003vjo.2_Missense_Mutation_p.D154H|ING3_uc003vjp.2_3'UTR|ING3_uc011kns.1_Missense_Mutation_p.D365H	NM_019071	NP_061944	Q9NXR8	ING3_HUMAN	inhibitor of growth family, member 3 isoform 1	380	PHD-type.			Missing (in Ref. 5; CAC48260).	histone H2A acetylation|histone H4 acetylation|positive regulation of apoptosis|regulation of growth|regulation of transcription, DNA-dependent|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|Piccolo NuA4 histone acetyltransferase complex	zinc ion binding			ovary(1)	1	all_neural(327;0.117)					TGATAACCAAGATGTAAGTAT	0.284		NA											15	62					0	0	0	0
ASB10	136371	broad.mit.edu	37	7	150878413	150878413	+	Silent	SNP	T	T	C			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr7:150878413T>C	uc003wjm.1	-	3	978	c.852A>G	c.(850-852)GCA>GCG	p.A284A	ASB10_uc003wjl.1_Silent_p.A284A|ASB10_uc003wjn.1_Silent_p.A224A	NM_001142459	NP_001135931	Q8WXI3	ASB10_HUMAN	ankyrin repeat and SOCS box-containing 10	239	ANK 4.				intracellular signal transduction						0			OV - Ovarian serous cystadenocarcinoma(82;0.00448)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		CATCAGGACATGCCCCCCGTC	0.652		NA											5	15					0	0	0	0
FGF20	26281	broad.mit.edu	37	8	16850824	16850824	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr8:16850824C>G	uc003wxc.1	-	3	526	c.393G>C	c.(391-393)GAG>GAC	p.E131D	FGF20_uc010lsv.1_RNA|FGF20_uc010lsw.1_Missense_Mutation_p.E97Q	NM_019851	NP_062825	Q9NP95	FGF20_HUMAN	fibroblast growth factor 20	131					cell-cell signaling|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway	extracellular region|soluble fraction	growth factor activity			lung(1)	1				Colorectal(111;0.0511)|COAD - Colon adenocarcinoma(73;0.207)		AAGTAAGTTTCTCCTGAAAGA	0.333		NA											45	132					0	0	0	0
LPL	4023	broad.mit.edu	37	8	19810909	19810909	+	Missense_Mutation	SNP	A	A	T			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr8:19810909A>T	uc003wzk.3	+	4	888	c.518A>T	c.(517-519)AAT>ATT	p.N173I		NM_000237	NP_000228	P06858	LIPL_HUMAN	lipoprotein lipase precursor	173					fatty acid biosynthetic process|lipoprotein metabolic process|phospholipid metabolic process|positive regulation of cholesterol storage|positive regulation of sequestering of triglyceride|triglyceride catabolic process|triglyceride homeostasis|very-low-density lipoprotein particle remodeling	anchored to membrane|chylomicron|plasma membrane|very-low-density lipoprotein particle	heparin binding|lipoprotein lipase activity|phospholipase activity|receptor binding|triglyceride lipase activity			ovary(1)|central_nervous_system(1)|pancreas(1)	3				Colorectal(111;0.0577)|COAD - Colon adenocarcinoma(73;0.216)	Clofibrate(DB00636)|Gemfibrozil(DB01241)|Orlistat(DB01083)	AGTCTGACCAATAAGAAAGTC	0.413		NA											29	41					0	0	0	0
MCM4	4173	broad.mit.edu	37	8	48887407	48887407	+	Silent	SNP	T	T	A			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr8:48887407T>A	uc003xqk.1	+	15	2345	c.2250T>A	c.(2248-2250)TCT>TCA	p.S750S	MCM4_uc003xql.1_Silent_p.S750S|MCM4_uc011ldi.1_Silent_p.S737S	NM_182746	NP_877423	P33991	MCM4_HUMAN	minichromosome maintenance complex component 4	750					cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	MCM complex	ATP binding|DNA binding|helicase activity|protein binding			ovary(2)|skin(2)	4		all_cancers(86;0.026)|all_epithelial(80;0.000748)|Lung NSC(129;0.00327)|all_lung(136;0.00354)				TAAGATTGTCTAACAAAGTTG	0.498		NA											12	159					0	0	0	0
SNTG1	54212	broad.mit.edu	37	8	51705261	51705261	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr8:51705261C>G	uc010lxy.1	+	20	1797	c.1426C>G	c.(1426-1428)CTT>GTT	p.L476V	SNTG1_uc003xqs.1_Missense_Mutation_p.L476V|SNTG1_uc010lxz.1_Missense_Mutation_p.L439V|SNTG1_uc011ldl.1_RNA	NM_018967	NP_061840	Q9NSN8	SNTG1_HUMAN	syntrophin, gamma 1	476					cell communication	cytoplasm|cytoskeleton|nucleus|ruffle membrane|syntrophin complex	actin binding|protein C-terminus binding			ovary(5)	5		all_cancers(86;0.00754)|all_epithelial(80;9.76e-05)|Lung NSC(129;0.000865)|all_lung(136;0.00249)|Colorectal(162;0.22)				ATTTGCTGTTCTTCACTGCAT	0.363		NA											18	101					0	0	0	0
TGS1	96764	broad.mit.edu	37	8	56698298	56698298	+	Missense_Mutation	SNP	G	G	C	rs139226926	byFrequency	TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr8:56698298G>C	uc003xsj.3	+	3	574	c.187G>C	c.(187-189)GAG>CAG	p.E63Q	TGS1_uc010lyh.2_5'UTR	NM_024831	NP_079107	Q96RS0	TGS1_HUMAN	trimethylguanosine synthase homolog	63					cellular lipid metabolic process|ncRNA metabolic process|regulation of transcription, DNA-dependent|RNA capping|spliceosomal snRNP assembly|transcription, DNA-dependent	Cajal body|cytosol	RNA trimethylguanosine synthase activity			ovary(1)|lung(1)|breast(1)	3		all_lung(136;0.119)|all_epithelial(80;0.125)|Lung NSC(129;0.147)	Epithelial(17;0.00027)|all cancers(17;0.00251)			GACAGAAGAAGAGGAAGGTGG	0.338		NA											10	37					0	0	0	0
FAM110B	90362	broad.mit.edu	37	8	59059795	59059795	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr8:59059795G>A	uc003xtj.1	+	5	1886	c.1006G>A	c.(1006-1008)GAC>AAC	p.D336N		NM_147189	NP_671722	Q8TC76	F110B_HUMAN	hypothetical protein LOC90362	336						microtubule organizing center|mitochondrion|nucleus				large_intestine(1)	1		all_epithelial(80;0.025)|all_lung(136;0.0274)|Lung NSC(129;0.0355)				CAGTGCCAATGACCGCGTGCC	0.458		NA											12	13					0	0	0	0
PAG1	55824	broad.mit.edu	37	8	81899630	81899630	+	Silent	SNP	C	C	T			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr8:81899630C>T	uc003ybz.2	-	6	960	c.249G>A	c.(247-249)CAG>CAA	p.Q83Q		NM_018440	NP_060910	Q9NWQ8	PAG1_HUMAN	phosphoprotein associated with glycosphingolipid	83	Cytoplasmic (Potential).				epidermal growth factor receptor signaling pathway|intracellular signal transduction|T cell receptor signaling pathway	integral to membrane|intracellular|membrane raft|plasma membrane	SH2 domain binding|SH3/SH2 adaptor activity				0	Lung NSC(7;5.76e-06)|all_lung(9;2e-05)		BRCA - Breast invasive adenocarcinoma(6;0.0567)|Epithelial(68;0.0634)|all cancers(69;0.197)			GTGCCCCATTCTGCTCACTGC	0.438		NA											12	62					0	0	0	0
ENY2	56943	broad.mit.edu	37	8	110348368	110348368	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr8:110348368G>A	uc003ynd.2	+	2	80	c.18G>A	c.(16-18)ATG>ATA	p.M6I	NUDCD1_uc003ynb.3_5'Flank|NUDCD1_uc010mcl.2_5'Flank|ENY2_uc003ync.2_Missense_Mutation_p.M1I	NM_020189	NP_064574	Q9NPA8	ENY2_HUMAN	enhancer of yellow 2 homolog	6					histone deubiquitination|mRNA transport|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	SAGA complex	ligand-dependent nuclear receptor transcription coactivator activity				0	all_neural(195;0.219)		OV - Ovarian serous cystadenocarcinoma(57;9.05e-13)			TTAGCAAGATGAACAAAGATG	0.358		NA											8	13					0	0	0	0
SYBU	55638	broad.mit.edu	37	8	110590243	110590243	+	Silent	SNP	A	A	G			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr8:110590243A>G	uc003ynj.3	-	6	901	c.738T>C	c.(736-738)CGT>CGC	p.R246R	SYBU_uc003yni.3_Silent_p.R243R|SYBU_uc003ynk.3_Silent_p.R127R|SYBU_uc010mco.2_Silent_p.R245R|SYBU_uc003ynl.3_Silent_p.R245R|SYBU_uc010mcp.2_Silent_p.R246R|SYBU_uc010mcq.2_Silent_p.R246R|SYBU_uc003yno.3_Silent_p.R127R|SYBU_uc010mcr.2_Silent_p.R246R|SYBU_uc003ynm.3_Silent_p.R245R|SYBU_uc003ynn.3_Silent_p.R245R|SYBU_uc010mcs.2_Silent_p.R127R|SYBU_uc010mct.2_Silent_p.R246R|SYBU_uc010mcu.2_Silent_p.R245R|SYBU_uc003ynp.3_Silent_p.R178R|SYBU_uc010mcv.2_Silent_p.R246R|SYBU_uc003ynh.3_Silent_p.R40R|SYBU_uc011lhw.1_Silent_p.R116R	NM_001099754	NP_001093224	Q9NX95	SYBU_HUMAN	Golgi-localized syntaphilin-related protein	246	Sufficient for interaction with KIF5B.					cytoplasmic membrane-bounded vesicle|cytoskeleton|Golgi membrane|integral to membrane				ovary(1)	1						ACCTTCCAGAACGCCTGAAAC	0.378		NA											30	113					0	0	0	0
PTPRD	5789	broad.mit.edu	37	9	8471058	8471058	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr9:8471058C>G	uc003zkk.2	-	30	4152	c.3441G>C	c.(3439-3441)TTG>TTC	p.L1147F	PTPRD_uc003zkp.2_Missense_Mutation_p.L736F|PTPRD_uc003zkq.2_Missense_Mutation_p.L736F|PTPRD_uc003zkr.2_Missense_Mutation_p.L731F|PTPRD_uc003zks.2_Missense_Mutation_p.L726F|PTPRD_uc003zkl.2_Missense_Mutation_p.L1138F|PTPRD_uc003zkm.2_Missense_Mutation_p.L1134F|PTPRD_uc003zkn.2_Missense_Mutation_p.L736F|PTPRD_uc003zko.2_Missense_Mutation_p.L733F	NM_002839	NP_002830	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	1147	Extracellular (Potential).				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			lung(14)|large_intestine(3)|ovary(2)|breast(2)|urinary_tract(1)	22		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		GAGATTTCTTCAAAGGCACAA	0.378		NA								TSP Lung(15;0.13)			40	18					0	0	0	0
ADAMTSL1	92949	broad.mit.edu	37	9	18753314	18753314	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr9:18753314G>A	uc003zne.3	+	16	2152	c.2025G>A	c.(2023-2025)TGG>TGA	p.W675*		NM_001040272	NP_001035362	Q8N6G6	ATL1_HUMAN	ADAMTS-like 1 isoform 4 precursor	675	TSP type-1 6.					proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			ovary(3)|upper_aerodigestive_tract(1)|lung(1)	5				GBM - Glioblastoma multiforme(50;1.29e-17)		TTGGCAAGTGGAGTCCATGTA	0.488		NA											10	2					0	0	0	0
FAM154A	158297	broad.mit.edu	37	9	18928327	18928327	+	Missense_Mutation	SNP	G	G	T			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr9:18928327G>T	uc003zni.1	-	4	1426	c.1148C>A	c.(1147-1149)CCT>CAT	p.P383H	FAM154A_uc010mip.1_Missense_Mutation_p.P191H	NM_153707	NP_714918	Q8IYX7	F154A_HUMAN	hypothetical protein LOC158297	383										pancreas(1)	1				GBM - Glioblastoma multiforme(50;6.53e-16)		GGTATTGATAGGCAGGTGGGG	0.582		NA											8	33					0.000157383	0.000164916	1	0
C9orf131	138724	broad.mit.edu	37	9	35044434	35044434	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr9:35044434C>T	uc003zvw.2	+	2	1837	c.1808C>T	c.(1807-1809)CCA>CTA	p.P603L	C9orf131_uc003zvu.2_Missense_Mutation_p.P555L|C9orf131_uc003zvv.2_Missense_Mutation_p.P530L|C9orf131_uc003zvx.2_Missense_Mutation_p.P568L	NM_203299	NP_976044	Q5VYM1	CI131_HUMAN	hypothetical protein LOC138724 isoform A	603											0	all_epithelial(49;0.22)		LUSC - Lung squamous cell carcinoma(32;0.00117)|Lung(28;0.00309)			TCTAAGCACCCAGCTTGTAAC	0.493		NA											31	101					0	0	0	0
C9orf131	138724	broad.mit.edu	37	9	35044709	35044709	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr9:35044709C>G	uc003zvw.2	+	2	2112	c.2083C>G	c.(2083-2085)CTA>GTA	p.L695V	C9orf131_uc003zvu.2_Missense_Mutation_p.L647V|C9orf131_uc003zvv.2_Missense_Mutation_p.L622V|C9orf131_uc003zvx.2_Missense_Mutation_p.L660V	NM_203299	NP_976044	Q5VYM1	CI131_HUMAN	hypothetical protein LOC138724 isoform A	695											0	all_epithelial(49;0.22)		LUSC - Lung squamous cell carcinoma(32;0.00117)|Lung(28;0.00309)			CTCTACTCCTCTACCAGAGCC	0.562		NA											13	30					0	0	0	0
ECM2	1842	broad.mit.edu	37	9	95256393	95256393	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr9:95256393C>T	uc004asf.3	-	10	2054	c.1904G>A	c.(1903-1905)AGA>AAA	p.R635K	CENPP_uc004arz.2_Intron|CENPP_uc010mqx.2_Intron	NM_001393	NP_001384	O94769	ECM2_HUMAN	extracellular matrix protein 2 precursor	Error:Variant_position_missing_in_O94769_after_alignment					cell-matrix adhesion		integrin binding			ovary(1)|skin(1)	2						CACATCTGATCTGTTTGTCAC	0.413		NA											11	60					0	0	0	0
PAEP	5047	broad.mit.edu	37	9	138454276	138454276	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr9:138454276G>A	uc004cge.1	+	2	277	c.233G>A	c.(232-234)AGA>AAA	p.R78K	PAEP_uc010naw.1_Missense_Mutation_p.R56K|PAEP_uc010naz.2_RNA|PAEP_uc010nay.2_Missense_Mutation_p.R78K|PAEP_uc010nba.1_Missense_Mutation_p.R78K|PAEP_uc004cgd.1_Missense_Mutation_p.R78K|PAEP_uc011mdp.1_Missense_Mutation_p.R56K|PAEP_uc004cgg.1_Missense_Mutation_p.R78K|PAEP_uc010nbc.1_Missense_Mutation_p.R78K|PAEP_uc004cgf.1_Missense_Mutation_p.R78K	NM_001018049	NP_001018059	P09466	PAEP_HUMAN	glycodelin precursor	78					multicellular organismal development	extracellular region	binding|transporter activity				0				OV - Ovarian serous cystadenocarcinoma(145;3.39e-07)|Epithelial(140;1.11e-06)|all cancers(34;2.04e-05)		GTTCTGCACAGATGGTGGGTT	0.622		NA											11	80					0	0	0	0
IL3RA	3563	broad.mit.edu	37	X	1471251	1471251	+	Silent	SNP	G	G	A			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chrX:1471251G>A	uc004cps.2	+	6	817	c.468G>A	c.(466-468)ACG>ACA	p.T156T	IL3RA_uc011mhd.1_Silent_p.T78T	NM_002183	NP_002174	P26951	IL3RA_HUMAN	interleukin 3 receptor, alpha precursor	156	Extracellular (Potential).					integral to membrane|plasma membrane	interleukin-3 receptor activity			skin(2)|lung(1)	3		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)			Sargramostim(DB00020)	ACTACAAAACGGATGCTCAGG	0.602		NA											86	151					0	0	0	0
ZMAT1	84460	broad.mit.edu	37	X	101159303	101159303	+	Missense_Mutation	SNP	T	T	C			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chrX:101159303T>C	uc011mrl.1	-	3	433	c.122A>G	c.(121-123)GAC>GGC	p.D41G	ZMAT1_uc004ein.2_5'UTR|ZMAT1_uc011mrm.1_5'UTR	NM_001011657	NP_001011657	Q5H9K5	ZMAT1_HUMAN	zinc finger, matrin type 1 isoform 1	Error:Variant_position_missing_in_A7MD47_after_alignment						nucleus	zinc ion binding			ovary(1)	1						CCAAATGGCGTCTGTGAATAA	0.299		NA											8	15					0	0	0	0
MAGEA4	4103	broad.mit.edu	37	X	151092296	151092296	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chrX:151092296G>A	uc004fez.2	+	3	316	c.160G>A	c.(160-162)GTG>ATG	p.V54M	MAGEA4_uc004ffa.2_Missense_Mutation_p.V54M|MAGEA4_uc004ffb.2_Missense_Mutation_p.V54M|MAGEA4_uc004ffc.2_Missense_Mutation_p.V54M|MAGEA4_uc004ffd.2_Missense_Mutation_p.V54M	NM_002362	NP_002353	P43358	MAGA4_HUMAN	melanoma antigen family A, 4	54							protein binding			ovary(1)|breast(1)|central_nervous_system(1)	3	Acute lymphoblastic leukemia(192;6.56e-05)					CCTGGAGGAAGTGCCTGCTGC	0.627		NA											40	10					0	0	0	0
FLNA	2316	broad.mit.edu	37	X	153596026	153596026	+	Missense_Mutation	SNP	A	A	T			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chrX:153596026A>T	uc004fkk.2	-	4	952	c.703T>A	c.(703-705)TGG>AGG	p.W235R	FLNA_uc010nuu.1_Missense_Mutation_p.W235R	NM_001110556	NP_001104026	P21333	FLNA_HUMAN	filamin A, alpha isoform 2	235	CH 2.|Actin-binding.				actin crosslink formation|actin cytoskeleton reorganization|cell junction assembly|cytoplasmic sequestering of protein|establishment of protein localization|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|negative regulation of protein catabolic process|negative regulation of sequence-specific DNA binding transcription factor activity|platelet activation|platelet degranulation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of transcription factor import into nucleus|protein localization at cell surface|protein stabilization|receptor clustering	cell cortex|cytosol|extracellular region|nucleus|plasma membrane	actin filament binding|Fc-gamma receptor I complex binding|glycoprotein binding|GTP-Ral binding|protein homodimerization activity|Rac GTPase binding|signal transducer activity|transcription factor binding			breast(6)	6	all_cancers(53;3.7e-16)|all_epithelial(53;2.97e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					ATGCCCAGCCAGTCATCCGCC	0.657		NA											60	23					0	0	0	0
TMSB4Y	9087	broad.mit.edu	37	Y	15816245	15816245	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chrY:15816245C>G	uc004ftb.2	+	1	799	c.30C>G	c.(28-30)ATC>ATG	p.I10M		NM_004202	NP_004193	O14604	TYB4Y_HUMAN	thymosin, beta 4, Y chromosome	10					actin cytoskeleton organization|sequestering of actin monomers	cytoplasm|cytoskeleton	actin binding				0						TGGCTGAGATCGAGAAATTCG	0.483		NA											4	5					0	0	0	0
NPHP4	261734	broad.mit.edu	37	1	5993234	5993237	+	Frame_Shift_Del	DEL	TACC	TACC	-			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr1:5993234_5993237delTACC	uc001alq.1	-	10	1538_1541	c.1272_1275delGGTA	c.(1270-1275)AAGGTAfs	p.K424fs	NPHP4_uc001als.1_RNA|NPHP4_uc009vlt.1_RNA|NPHP4_uc001alt.1_RNA	NM_015102	NP_055917	O75161	NPHP4_HUMAN	nephroretinin	424_425					actin cytoskeleton organization|cell-cell adhesion|signal transduction|visual behavior	cell-cell junction|centrosome|cilium|microtubule basal body	protein binding|structural molecule activity			pancreas(1)	1	Ovarian(185;0.0634)	all_cancers(23;7.53e-41)|all_epithelial(116;3.96e-23)|all_lung(118;5.12e-09)|all_hematologic(16;5.45e-07)|Lung NSC(185;5.49e-07)|all_neural(13;3.21e-06)|Acute lymphoblastic leukemia(12;3.44e-05)|Breast(487;0.000601)|Renal(390;0.0007)|Colorectal(325;0.00113)|Hepatocellular(190;0.00213)|Glioma(11;0.00223)|Myeloproliferative disorder(586;0.0256)|Ovarian(437;0.04)|Lung SC(97;0.128)|Medulloblastoma(700;0.213)		Epithelial(90;1.69e-36)|GBM - Glioblastoma multiforme(13;5.07e-29)|OV - Ovarian serous cystadenocarcinoma(86;1.05e-19)|Colorectal(212;4.54e-07)|COAD - Colon adenocarcinoma(227;3.14e-05)|Kidney(185;0.00012)|BRCA - Breast invasive adenocarcinoma(365;0.00102)|KIRC - Kidney renal clear cell carcinoma(229;0.00179)|STAD - Stomach adenocarcinoma(132;0.00472)|READ - Rectum adenocarcinoma(331;0.0649)		TGGCTGAGGGTACCTTGTAGACCA	0.5		NA											23	74	---	---	---	---	NA	NA	NA	NA
DIP2C	22982	broad.mit.edu	37	10	329222	329222	+	Frame_Shift_Del	DEL	A	A	-			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr10:329222delA	uc001ifp.2	-	35	4374	c.4284delT	c.(4282-4284)GATfs	p.D1428fs		NM_014974	NP_055789	Q9Y2E4	DIP2C_HUMAN	DIP2 disco-interacting protein 2 homolog C	1428						nucleus	catalytic activity|transcription factor binding			breast(4)|ovary(2)|large_intestine(1)	7		all_cancers(4;0.00336)|all_lung(4;0.00732)|Lung NSC(4;0.00785)|all_epithelial(10;0.0159)|Colorectal(49;0.235)	OV - Ovarian serous cystadenocarcinoma(33;0.136)	Epithelial(11;0.0123)|all cancers(11;0.0467)|Lung(33;0.0864)|OV - Ovarian serous cystadenocarcinoma(14;0.106)		CTCCATTTGCATCTGTGAGCT	0.547		NA											12	99	---	---	---	---	NA	NA	NA	NA
CCND1	595	broad.mit.edu	37	11	69466013	69466021	+	In_Frame_Del	DEL	CTTGCACAC	CTTGCACAC	-			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr11:69466013_69466021delCTTGCACAC	uc001opa.2	+	5	1060_1068	c.851_859delCTTGCACAC	c.(850-861)GCTTGCACACCC>GCC	p.CTP285del		NM_053056	NP_444284	P24385	CCND1_HUMAN	cyclin D1	285_287					cell division|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|mitotic cell cycle G1/S transition DNA damage checkpoint|positive regulation of cyclin-dependent protein kinase activity|positive regulation of protein phosphorylation|response to drug|response to UV-A|S phase of mitotic cell cycle	cyclin-dependent protein kinase holoenzyme complex|cytosol|membrane|nucleoplasm	protein kinase binding			ovary(1)|lung(1)	2	all_cancers(3;2.01e-114)|all_epithelial(3;3.59e-122)|Breast(3;5.4e-34)|all_lung(4;1.99e-21)|Lung NSC(4;4.65e-21)|Hepatocellular(3;8.22e-16)|Melanoma(5;1.89e-05)|Ovarian(3;0.0348)		Epithelial(3;7.2e-57)|all cancers(3;7.75e-51)|BRCA - Breast invasive adenocarcinoma(2;4.9e-48)|Lung(3;1.13e-16)|LUSC - Lung squamous cell carcinoma(11;3.74e-15)|STAD - Stomach adenocarcinoma(18;0.0278)|LUAD - Lung adenocarcinoma(13;0.0537)		Arsenic trioxide(DB01169)	gtggaCCTGGCTTGCACACCCACCGACGT	0.612		NA	T	IGH@|FSTL3	CLL|B-ALL|breast					Multiple Myeloma(6;0.086)			6	7	---	---	---	---	NA	NA	NA	NA
RARG	5916	broad.mit.edu	37	12	53608326	53608338	+	Frame_Shift_Del	DEL	ATAGCTGTCAGGT	ATAGCTGTCAGGT	-			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr12:53608326_53608338delATAGCTGTCAGGT	uc001sce.2	-	6	1013_1025	c.528_540delACCTGACAGCTAT	c.(526-540)TCACCTGACAGCTATfs	p.S176fs	RARG_uc001scd.2_Frame_Shift_Del_p.S165fs|RARG_uc010sob.1_Frame_Shift_Del_p.S154fs|RARG_uc001scf.2_Frame_Shift_Del_p.S176fs|RARG_uc001scg.2_Frame_Shift_Del_p.S104fs|RARG_uc010soc.1_Frame_Shift_Del_p.S55fs|RARG_uc010sod.1_Frame_Shift_Del_p.S213fs	NM_000966	NP_000957	P13631	RARG_HUMAN	retinoic acid receptor, gamma isoform 1	176_180	Hinge.				canonical Wnt receptor signaling pathway|embryonic eye morphogenesis|embryonic hindlimb morphogenesis|negative regulation of cell proliferation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of apoptosis|positive regulation of transcription from RNA polymerase II promoter|regulation of cell size|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to retinoic acid	integral to membrane|transcription factor complex	retinoic acid receptor activity|retinoid X receptor binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			breast(2)|ovary(1)|lung(1)	4					Acitretin(DB00459)|Adapalene(DB00210)|Alitretinoin(DB00523)|Etretinate(DB00926)|Tazarotene(DB00799)|Tretinoin(DB00755)	GGCTCAGCTCATAGCTGTCAGGTGACCCTTCTT	0.559		NA											9	48	---	---	---	---	NA	NA	NA	NA
RAP1B	5908	broad.mit.edu	37	12	69042549	69042549	+	Frame_Shift_Del	DEL	A	A	-			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr12:69042549delA	uc001sub.2	+	2	208	c.45delA	c.(43-45)GGAfs	p.G15fs	RAP1B_uc010ste.1_Intron|RAP1B_uc001suc.2_Frame_Shift_Del_p.G15fs|RAP1B_uc010stf.1_Frame_Shift_Del_p.G15fs|RAP1B_uc010stg.1_Frame_Shift_Del_p.G15fs|RAP1B_uc010sth.1_Frame_Shift_Del_p.G15fs|RAP1B_uc010sti.1_Frame_Shift_Del_p.G15fs	NM_001089704	NP_001083173	P61224	RAP1B_HUMAN	SubName: Full=Ras-related protein Rap-1A; SubName: Full=cDNA FLJ75985, highly similar to Homo sapiens RAP1A, member of RAS oncogene family (RAP1A), transcript variant 2, mRNA; SubName: Full=RAP1A, member of RAS oncogene family;	15	GTP.				blood coagulation|energy reserve metabolic process|regulation of establishment of cell polarity|regulation of insulin secretion	cell-cell junction|cytosol	GDP binding|GTP binding|GTPase activity|protein binding				0	Breast(13;1.24e-05)		Lung(24;0.000131)|LUAD - Lung adenocarcinoma(15;0.00107)|STAD - Stomach adenocarcinoma(21;0.00694)	GBM - Glioblastoma multiforme(7;0.000306)		GAGGCGTTGGAAAGTCTGCTT	0.363		NA											13	33	---	---	---	---	NA	NA	NA	NA
TESC	54997	broad.mit.edu	37	12	117479755	117479755	+	Frame_Shift_Del	DEL	C	C	-			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr12:117479755delC	uc001twh.2	-	7	728	c.723delG	c.(721-723)CTGfs	p.L241fs	TESC_uc001twi.2_RNA	NM_017899	NP_060369	Q96BS2	TESC_HUMAN	tescalcin	188					negative regulation of cell proliferation|positive regulation of megakaryocyte differentiation|positive regulation of transcription, DNA-dependent|regulation of cell adhesion mediated by integrin	cytoplasm|lamellipodium|nucleus|plasma membrane|ruffle	calcium ion binding|magnesium ion binding|phosphatase inhibitor activity|protein binding				0	all_neural(191;0.117)|Medulloblastoma(191;0.163)			BRCA - Breast invasive adenocarcinoma(302;0.0297)		CACCCACCTTCAGGAAGTCCT	0.632		NA											2	4	---	---	---	---	NA	NA	NA	NA
TTN	7273	broad.mit.edu	37	2	179458509	179458510	+	Frame_Shift_Ins	INS	-	-	T			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr2:179458509_179458510insT	uc010zfg.1	-	247	51037_51038	c.50813_50814insA	c.(50812-50814)GATfs	p.D16938fs	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Frame_Shift_Ins_p.D10633fs|TTN_uc010zfi.1_Frame_Shift_Ins_p.D10566fs|TTN_uc010zfj.1_Frame_Shift_Ins_p.D10441fs	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	17865							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TGCCTCCATCATCTAAAGGAGG	0.416		NA											19	41	---	---	---	---	NA	NA	NA	NA
TTN	7273	broad.mit.edu	37	2	179616191	179616192	+	Frame_Shift_Ins	INS	-	-	T			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr2:179616191_179616192insT	uc002unb.2	-	46	11159_11160	c.10935_10936insA	c.(10933-10938)AAACAAfs	p.K3645fs	TTN_uc010zfg.1_Intron|TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Intron	NM_133379	NP_596870	Q8WZ42	TITIN_HUMAN	titin isoform novex-3	9490_Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCCACATCTTGTTTTTTGTTAA	0.371		NA											47	95	---	---	---	---	NA	NA	NA	NA
C2orf83	56918	broad.mit.edu	37	2	228476153	228476165	+	Frame_Shift_Del	DEL	TCTTGTGGCTTCT	TCTTGTGGCTTCT	-			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr2:228476153_228476165delTCTTGTGGCTTCT	uc002vph.2	-	3	633_645	c.398_410delAGAAGCCACAAGA	c.(397-411)AAGAAGCCACAAGATfs	p.K133fs	C2orf83_uc010zlu.1_3'UTR	NM_020161	NP_064546	Q53S99	CB083_HUMAN	hypothetical protein LOC56918 isoform 1	133_137						membrane	folic acid binding|reduced folate carrier activity				0						GAGCACCGAATCTTGTGGCTTCTTGTTCTCTGT	0.493		NA											9	89	---	---	---	---	NA	NA	NA	NA
PTPRT	11122	broad.mit.edu	37	20	41306573	41306573	+	Frame_Shift_Del	DEL	G	G	-			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr20:41306573delG	uc002xkg.2	-	7	1270	c.1086delC	c.(1084-1086)CTCfs	p.L362fs	PTPRT_uc010ggj.2_Frame_Shift_Del_p.L362fs	NM_007050	NP_008981	O14522	PTPRT_HUMAN	protein tyrosine phosphatase, receptor type, T	362	Extracellular (Potential).|Fibronectin type-III 1.				homophilic cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	cell surface|integral to membrane|plasma membrane	alpha-catenin binding|beta-catenin binding|cadherin binding|delta-catenin binding|gamma-catenin binding|protein tyrosine phosphatase activity|receptor activity			skin(8)|ovary(7)|lung(5)	20		Myeloproliferative disorder(115;0.00452)|Lung NSC(126;0.0573)|all_lung(126;0.0783)				CTGGTCGTGTGAGGAGCACTC	0.567		NA											24	106	---	---	---	---	NA	NA	NA	NA
LYAR	55646	broad.mit.edu	37	4	4270287	4270287	+	Frame_Shift_Del	DEL	A	A	-			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr4:4270287delA	uc011bvy.1	-	9	1118	c.975delT	c.(973-975)AATfs	p.N325fs	LYAR_uc011bvx.1_Frame_Shift_Del_p.N208fs|LYAR_uc003ght.2_Frame_Shift_Del_p.N325fs	NM_001145725	NP_001139197	Q9NX58	LYAR_HUMAN	Ly1 antibody reactive homolog	325	Lys-rich.					nucleolus	metal ion binding|protein binding				0				UCEC - Uterine corpus endometrioid carcinoma (64;0.168)		TGGTTATTTCATTGTCTGGGG	0.333		NA											10	100	---	---	---	---	NA	NA	NA	NA
HIST1H1C	3006	broad.mit.edu	37	6	26056548	26056549	+	Frame_Shift_Ins	INS	-	-	A	rs10425	byFrequency	TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr6:26056548_26056549insA	uc003nfw.2	-	1	151_152	c.108_109insT	c.(106-111)TCTGGTfs	p.S36fs		NM_005319	NP_005310	P16403	H12_HUMAN	histone cluster 1, H1c	36_37	H15.				nucleosome assembly	nucleosome|nucleus	DNA binding			ovary(3)|skin(2)	5						ACCGGGGGACCAGACGCCTTAC	0.634		NA											39	15	---	---	---	---	NA	NA	NA	NA
POR	5447	broad.mit.edu	37	7	75612906	75612907	+	Frame_Shift_Ins	INS	-	-	G			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr7:75612906_75612907insG	uc003udy.2	+	9	981_982	c.899_900insG	c.(898-900)GAGfs	p.E300fs	POR_uc011kgc.1_Frame_Shift_Ins_p.E108fs|POR_uc011kgd.1_Frame_Shift_Ins_p.E199fs|POR_uc011kge.1_Frame_Shift_Ins_p.E38fs|POR_uc003uea.2_5'Flank	NM_000941	NP_000932	P16435	NCPR_HUMAN	cytochrome P450 reductase	297	FAD-binding FR-type.				cellular organofluorine metabolic process|positive regulation of monooxygenase activity	endoplasmic reticulum membrane	iron ion binding|NADPH-hemoprotein reductase activity			central_nervous_system(1)	1					Benzphetamine(DB00865)|Daunorubicin(DB00694)|Lipoic Acid(DB00166)|Menadione(DB00170)|Methoxyflurane(DB01028)|Mitomycin(DB00305)|Nilutamide(DB00665)	CAGGGAACCGAGCGCCACCTCA	0.599		NA											23	82	---	---	---	---	NA	NA	NA	NA
C9orf173	441476	broad.mit.edu	37	9	140145786	140145788	+	In_Frame_Del	DEL	CAT	CAT	-			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr9:140145786_140145788delCAT	uc004cmk.1	+	1	57_59	c.45_47delCAT	c.(43-48)TACATC>TAC	p.I16del	C9orf173_uc004cmj.1_In_Frame_Del_p.I17del|C9orf173_uc011meu.1_RNA|C9orf173_uc010ncd.1_RNA|C9orf173_uc011mev.1_In_Frame_Del_p.I16del|C9orf173_uc004cml.1_In_Frame_Del_p.I16del			Q8N7X2	CI173_HUMAN	SubName: Full=LOC441476 protein;	17										pancreas(1)	1						CAAATTTTTACATCAATGGAGGC	0.567		NA											138	40	---	---	---	---	NA	NA	NA	NA