Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	isArtifactMode	oxoGCut
CAMTA1	23261	broad.mit.edu	37	1	7798213	7798213	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr1:7798213G>A	uc001aoi.2	+	16	4060	c.3853G>A	c.(3853-3855)GAG>AAG	p.E1285K	CAMTA1_uc010nzv.1_Missense_Mutation_p.E372K|CAMTA1_uc001aok.3_Missense_Mutation_p.E328K|CAMTA1_uc001aoj.2_Missense_Mutation_p.E241K	NM_015215	NP_056030	Q9Y6Y1	CMTA1_HUMAN	calmodulin-binding transcription activator 1	1285					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	calmodulin binding			ovary(5)|central_nervous_system(2)|breast(1)|pancreas(1)	9	Ovarian(185;0.0634)	all_epithelial(116;8.38e-23)|all_lung(118;5.87e-07)|Lung NSC(185;3.43e-06)|Renal(390;0.000219)|Breast(487;0.000307)|Colorectal(325;0.000615)|Hepatocellular(190;0.0088)|Myeloproliferative disorder(586;0.0303)|Ovarian(437;0.0388)		UCEC - Uterine corpus endometrioid carcinoma (279;0.101)|Colorectal(212;1.33e-05)|COAD - Colon adenocarcinoma(227;0.000235)|BRCA - Breast invasive adenocarcinoma(304;0.000864)|Kidney(185;0.00244)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0179)|READ - Rectum adenocarcinoma(331;0.133)		GTCTGTCCCCGAGACACTCAG	0.552		NA											23	14					0	0	0	0
MACF1	23499	broad.mit.edu	37	1	39951383	39951383	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr1:39951383G>A	uc010oiu.1	+	64	17865	c.17734G>A	c.(17734-17736)GGG>AGG	p.G5912R	MACF1_uc010ois.1_Missense_Mutation_p.G5404R|MACF1_uc001cde.1_Missense_Mutation_p.G318R|MACF1_uc001cdf.1_Missense_Mutation_p.G287R|MACF1_uc001cdg.2_3'UTR|MACF1_uc001cdh.2_3'UTR	NM_033044	NP_149033	Q9UPN3	MACF1_HUMAN	microfilament and actin filament cross-linker	7362	C-terminal tail (By similarity).				cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			ovary(8)|breast(3)|central_nervous_system(3)|skin(2)	16	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			CTCCAGGAGAGGGCTAAACAA	0.542		NA											6	129					0	0	0	0
ZNF643	65243	broad.mit.edu	37	1	40929123	40929123	+	Silent	SNP	C	C	G			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr1:40929123C>G	uc001cfn.1	+	5	1764	c.1467C>G	c.(1465-1467)TCC>TCG	p.S489S	ZNF643_uc001cfl.1_Silent_p.S387S|ZNF643_uc001cfm.1_Silent_p.S355S	NM_023070	NP_075558	Q9UJL9	ZN643_HUMAN	zinc finger protein 643	489	C2H2-type 8.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2	Ovarian(52;0.00769)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0393)	OV - Ovarian serous cystadenocarcinoma(33;5.25e-18)			ATGATTCATCCTTTGCTAAAC	0.388		NA											4	47					0	0	0	0
ST3GAL3	6487	broad.mit.edu	37	1	44365306	44365306	+	Silent	SNP	T	T	A			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr1:44365306T>A	uc001ckc.2	+	9	828	c.651T>A	c.(649-651)CCT>CCA	p.P217P	ST3GAL3_uc010okj.1_RNA|ST3GAL3_uc001cjz.2_Silent_p.P232P|ST3GAL3_uc001cka.2_Intron|ST3GAL3_uc001ckb.2_Silent_p.P286P|ST3GAL3_uc001ckd.2_Silent_p.P271P|ST3GAL3_uc001cke.2_Silent_p.P201P|ST3GAL3_uc001ckf.2_Silent_p.P255P|ST3GAL3_uc001ckg.2_Silent_p.P217P|ST3GAL3_uc001ckh.2_Intron|ST3GAL3_uc001cki.2_Intron|ST3GAL3_uc009vwv.2_Silent_p.P217P|ST3GAL3_uc001ckj.2_RNA|ST3GAL3_uc009vww.2_Intron|ST3GAL3_uc001ckk.2_Silent_p.P186P|ST3GAL3_uc009vwy.2_Silent_p.P123P|ST3GAL3_uc009vwx.2_RNA|ST3GAL3_uc001ckm.2_Intron|ST3GAL3_uc001ckl.2_Intron|ST3GAL3_uc009vwz.2_Intron|ST3GAL3_uc001ckn.2_Intron|ST3GAL3_uc001ckp.2_Intron|ST3GAL3_uc001cko.2_Silent_p.P201P|ST3GAL3_uc009vxa.2_Silent_p.P4P|ST3GAL3_uc001ckq.2_Intron|ST3GAL3_uc001ckr.2_Silent_p.P170P|ST3GAL3_uc009vxb.2_Intron	NM_006279	NP_006270	Q11203	SIAT6_HUMAN	sialyltransferase 6 isoform j	217	Lumenal (Potential).				protein glycosylation	extracellular region|Golgi cisterna membrane|integral to Golgi membrane	N-acetyllactosaminide alpha-2,3-sialyltransferase activity			ovary(3)	3	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0518)				TGCAGCGGCCTGAGCAGTACG	0.537		NA											42	54					0	0	0	0
CC2D1B	200014	broad.mit.edu	37	1	52823543	52823543	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr1:52823543C>G	uc001ctq.1	-	14	1645	c.1507G>C	c.(1507-1509)GCC>CCC	p.A503P	CC2D1B_uc001ctr.2_Missense_Mutation_p.A43P|CC2D1B_uc001cts.2_Missense_Mutation_p.A188P	NM_032449	NP_115825	Q5T0F9	C2D1B_HUMAN	coiled-coil and C2 domain containing 1B	503										ovary(2)	2						GGTTTCTTGGCCACTGGGGCC	0.602		NA											30	11					0	0	0	0
CLCA1	1179	broad.mit.edu	37	1	86961316	86961316	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr1:86961316C>T	uc001dlt.2	+	12	2200	c.2071C>T	c.(2071-2073)CAG>TAG	p.Q691*		NM_001285	NP_001276	A8K7I4	CLCA1_HUMAN	chloride channel accessory 1 precursor	691					calcium ion transport	extracellular space|integral to plasma membrane	chloride channel activity			ovary(1)	1		Lung NSC(277;0.239)		all cancers(265;0.0249)|Epithelial(280;0.0476)		AGTGATACCCCAGCAGAGTGG	0.448		NA											21	7					0	0	0	0
NBPF15	284565	broad.mit.edu	37	1	148594407	148594407	+	Missense_Mutation	SNP	G	G	A	rs144416833	byFrequency	TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr1:148594407G>A	uc001esc.2	+	19	2269	c.1780G>A	c.(1780-1782)GTG>ATG	p.V594M		NM_173638	NP_775909	Q8N660	NBPFF_HUMAN	hypothetical protein LOC284565	594	NBPF 6.					cytoplasm					0	all_hematologic(923;0.032)					GCTCTACGGCGTGCTGATGGA	0.458		NA											124	192					0	0	0	0
SNX27	81609	broad.mit.edu	37	1	151640992	151640992	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr1:151640992C>T	uc001eyn.1	+	7	1046	c.1030C>T	c.(1030-1032)CAG>TAG	p.Q344*	SNX27_uc001eyo.2_Nonsense_Mutation_p.Q251*|SNX27_uc001eyp.2_Nonsense_Mutation_p.Q158*	NM_030918	NP_112180	Q96L92	SNX27_HUMAN	sorting nexin family member 27	344	Ras-associating.				cell communication|protein transport|signal transduction	cytosol|early endosome	phosphatidylinositol binding|protein binding			ovary(2)|central_nervous_system(1)	3	Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		LUSC - Lung squamous cell carcinoma(543;0.181)			ACTCTACATTCAGAATTATAC	0.383		NA											30	92					0	0	0	0
FLG	2312	broad.mit.edu	37	1	152276850	152276850	+	Silent	SNP	C	C	T	rs139345866		TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr1:152276850C>T	uc001ezu.1	-	3	10548	c.10512G>A	c.(10510-10512)TCG>TCA	p.S3504S		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	3504	Ser-rich.|Filaggrin 21.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CATGGTGATGCGACCATGAGT	0.577		NA							Ichthyosis				138	227					0	0	0	0
LMNA	4000	broad.mit.edu	37	1	156106747	156106747	+	Silent	SNP	G	G	A			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr1:156106747G>A	uc001fni.2	+	8	1665	c.1416G>A	c.(1414-1416)CAG>CAA	p.Q472Q	LMNA_uc001fnf.1_Silent_p.Q472Q|LMNA_uc001fng.2_Silent_p.Q472Q|LMNA_uc001fnh.2_Silent_p.Q472Q|LMNA_uc009wro.1_Silent_p.Q472Q|LMNA_uc010pgz.1_Silent_p.Q360Q|LMNA_uc001fnj.2_Silent_p.Q391Q|LMNA_uc001fnk.2_Silent_p.Q373Q|LMNA_uc009wrp.2_3'UTR|LMNA_uc010pha.1_Silent_p.Q128Q	NM_170707	NP_733821	P02545	LMNA_HUMAN	lamin A/C isoform 1 precursor	472	Tail.				cellular component disassembly involved in apoptosis|cellular response to hypoxia|establishment or maintenance of microtubule cytoskeleton polarity|muscle organ development|positive regulation of cell aging|regulation of apoptosis|regulation of cell migration	cytoplasm|lamin filament|nuclear envelope|nuclear envelope|perinuclear region of cytoplasm	protein binding|structural molecule activity|structural molecule activity			ovary(2)	2	Hepatocellular(266;0.158)					TCAAGCGCCAGAATGGAGATG	0.592		NA							Werner_syndrome|Hutchinson-Gilford_Progeria_Syndrome				23	19					0	0	0	0
KIAA1614	57710	broad.mit.edu	37	1	180910242	180910242	+	Missense_Mutation	SNP	A	A	G			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr1:180910242A>G	uc001gok.2	+	7	3047	c.2980A>G	c.(2980-2982)AAG>GAG	p.K994E	KIAA1614_uc001gol.1_Missense_Mutation_p.K615E|KIAA1614_uc001gom.1_Missense_Mutation_p.K85E	NM_020950	NP_066001	Q5VZ46	K1614_HUMAN	hypothetical protein LOC57710	994	Ser-rich.									ovary(3)|skin(1)	4						GGACCAGAACAAGAAAAGGAG	0.642		NA											6	47					0	0	0	0
PRG4	10216	broad.mit.edu	37	1	186276981	186276981	+	Silent	SNP	A	A	G			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr1:186276981A>G	uc001gru.3	+	7	2181	c.2130A>G	c.(2128-2130)AAA>AAG	p.K710K	PRG4_uc001grt.3_Silent_p.K669K|PRG4_uc009wyl.2_Silent_p.K617K|PRG4_uc009wym.2_Silent_p.K576K|PRG4_uc010poo.1_Intron	NM_005807	NP_005798	Q92954	PRG4_HUMAN	proteoglycan 4 isoform A	710	59 X 8 AA repeats of K-X-P-X-P-T-T-X.|43; approximate.				cell proliferation|immune response	extracellular region	polysaccharide binding|protein binding|scavenger receptor activity			skin(1)	1						CTACCCCTAAAGGGACTGCTC	0.582		NA											4	196					0	0	0	0
TPR	7175	broad.mit.edu	37	1	186321170	186321170	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr1:186321170C>G	uc001grv.2	-	19	2704	c.2407G>C	c.(2407-2409)GAG>CAG	p.E803Q		NM_003292	NP_003283	P12270	TPR_HUMAN	nuclear pore complex-associated protein TPR	803	Potential.				carbohydrate metabolic process|glucose transport|mitotic cell cycle spindle assembly checkpoint|mRNA transport|protein import into nucleus|regulation of glucose transport|seryl-tRNA aminoacylation|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytoplasm|nuclear membrane|nuclear pore|nucleoplasm	ATP binding|protein binding|serine-tRNA ligase activity			ovary(2)|lung(2)|urinary_tract(1)|central_nervous_system(1)|skin(1)	7		Breast(1374;0.000659)|Lung SC(1967;0.0262)|Prostate(1639;0.157)		Colorectal(1306;1.12e-05)|KIRC - Kidney renal clear cell carcinoma(1967;0.00553)		AACAAAGACTCTCTTTGCTGA	0.318		NA	T	NTRK1	papillary thyroid								19	100					0	0	0	0
CR1	1378	broad.mit.edu	37	1	207751469	207751469	+	Silent	SNP	C	C	A			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr1:207751469C>A	uc001hfy.2	+	21	3647	c.3507C>A	c.(3505-3507)GGC>GGA	p.G1169G	CR1_uc009xcl.1_Silent_p.G719G|CR1_uc001hfx.2_Silent_p.G1619G	NM_000573	NP_000564	P17927	CR1_HUMAN	complement receptor 1 isoform F precursor	1169	Extracellular (Potential).|Sushi 18.				complement activation, classical pathway|innate immune response	integral to plasma membrane	complement receptor activity			ovary(3)	3						GTCAGCCTGGCTTTGTCATGA	0.483		NA											8	115					0.00010058	0.000118119	1	0
LAMB3	3914	broad.mit.edu	37	1	209796421	209796421	+	Missense_Mutation	SNP	A	A	C			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr1:209796421A>C	uc001hhg.2	-	16	2852	c.2462T>G	c.(2461-2463)GTC>GGC	p.V821G	LAMB3_uc009xco.2_Missense_Mutation_p.V821G|LAMB3_uc001hhh.2_Missense_Mutation_p.V821G|LAMB3_uc010psl.1_RNA	NM_001017402	NP_001017402	Q13751	LAMB3_HUMAN	laminin, beta 3 precursor	821	Domain I.				cell adhesion|epidermis development|hemidesmosome assembly		structural molecule activity			central_nervous_system(2)|skin(2)|large_intestine(1)|ovary(1)	6				OV - Ovarian serous cystadenocarcinoma(81;0.0519)		CCTGGGAAGGACACCCCTGCA	0.632		NA											44	60					0	0	0	0
PTPN14	5784	broad.mit.edu	37	1	214542900	214542900	+	Silent	SNP	C	C	T			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr1:214542900C>T	uc001hkk.1	-	17	3442	c.3171G>A	c.(3169-3171)AAG>AAA	p.K1057K		NM_005401	NP_005392	Q15678	PTN14_HUMAN	protein tyrosine phosphatase, non-receptor type	1057	Tyrosine-protein phosphatase.				lymphangiogenesis	cytoplasm|cytoskeleton	protein tyrosine phosphatase activity|receptor tyrosine kinase binding			breast(2)|ovary(1)|kidney(1)|skin(1)	5				OV - Ovarian serous cystadenocarcinoma(81;0.00181)|all cancers(67;0.00194)|Epithelial(68;0.0157)|GBM - Glioblastoma multiforme(131;0.155)		GGTGCTTGACCTTCAAGCCCG	0.478		NA											94	204					0	0	0	0
LEFTY2	7044	broad.mit.edu	37	1	226125198	226125198	+	Silent	SNP	C	C	A			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr1:226125198C>A	uc001hpt.1	-	4	1124	c.1044G>T	c.(1042-1044)GTG>GTT	p.V348V	LEFTY2_uc010pvk.1_Silent_p.V314V|LEFTY2_uc009xek.1_3'UTR	NM_003240	NP_003231	O00292	LFTY2_HUMAN	endometrial bleeding associated factor	348					cell growth|multicellular organismal development|platelet activation|platelet degranulation|transforming growth factor beta receptor signaling pathway	extracellular space|platelet alpha granule lumen	cytokine activity|growth factor activity|transforming growth factor beta receptor binding				0	Breast(184;0.197)					TGCACTTCTGCACCCTCATGT	0.617		NA											35	59					3.11e-16	4.07e-16	1	0
LIN9	286826	broad.mit.edu	37	1	226454018	226454018	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr1:226454018C>T	uc001hqa.2	-	9	1190	c.880G>A	c.(880-882)GAG>AAG	p.E294K	LIN9_uc001hqb.2_Missense_Mutation_p.E259K|LIN9_uc001hqc.2_Missense_Mutation_p.E226K|LIN9_uc009xel.1_Missense_Mutation_p.E259K	NM_173083	NP_775106	Q5TKA1	LIN9_HUMAN	lin-9 homolog	278	Sufficient for interaction with RB1.				cell cycle|DNA replication	nucleoplasm					0	Breast(184;0.158)			GBM - Glioblastoma multiforme(131;0.131)		GGCATTGTCTCATGAGGTTCA	0.363		NA											9	23					0	0	0	0
CABC1	56997	broad.mit.edu	37	1	227170663	227170663	+	Silent	SNP	C	C	T			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr1:227170663C>T	uc001hqm.1	+	13	4427	c.1008C>T	c.(1006-1008)TTC>TTT	p.F336F	CABC1_uc001hqn.1_Silent_p.F336F|CABC1_uc009xeq.1_Silent_p.F284F|CABC1_uc010pvq.1_Silent_p.F57F|CABC1_uc010pvr.1_Intron|CABC1_uc001hqo.1_Silent_p.F57F|CABC1_uc009xer.1_5'UTR	NM_020247	NP_064632	Q8NI60	ADCK3_HUMAN	chaperone, ABC1 activity of bc1 complex like	336	Protein kinase.				cell death	mitochondrion	ATP binding|protein serine/threonine kinase activity				0		Prostate(94;0.0771)				AGCGGCCCTTCGCCGCCGCAT	0.642		NA											3	5					0	0	0	0
OR1C1	26188	broad.mit.edu	37	1	247921171	247921171	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr1:247921171C>G	uc010pza.1	-	1	538	c.538G>C	c.(538-540)GAT>CAT	p.D180H		NM_012353	NP_036485	Q15619	OR1C1_HUMAN	olfactory receptor, family 1, subfamily C,	180	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	all_cancers(71;4.34e-05)|all_epithelial(71;1.13e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0786)|Lung NSC(105;0.0858)	all_cancers(173;0.0247)	OV - Ovarian serous cystadenocarcinoma(106;0.0168)			GGATTGAGATCACAGAAGAAA	0.483		NA											17	29					0	0	0	0
OR11L1	391189	broad.mit.edu	37	1	248005020	248005020	+	Missense_Mutation	SNP	T	T	A			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr1:248005020T>A	uc001idn.1	-	1	179	c.179A>T	c.(178-180)TAC>TTC	p.Y60F		NM_001001959	NP_001001959	Q8NGX0	O11L1_HUMAN	olfactory receptor, family 11, subfamily L,	60	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|pancreas(1)|skin(1)	3	all_cancers(71;8.78e-05)|all_epithelial(71;9.15e-06)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.0786)|Lung NSC(105;0.0858)		OV - Ovarian serous cystadenocarcinoma(106;0.0319)			GAGGAACATGTACATAGGGGA	0.547		NA											12	21					0	0	0	0
OR2T12	127064	broad.mit.edu	37	1	248458698	248458698	+	Silent	SNP	C	C	T			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr1:248458698C>T	uc010pzj.1	-	1	183	c.183G>A	c.(181-183)CTG>CTA	p.L61L		NM_001004692	NP_001004692	Q8NG77	O2T12_HUMAN	olfactory receptor, family 2, subfamily T,	61	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)	3	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0201)			AAAGTTGGCTCAGGAGGAAGT	0.552		NA											54	58					0	0	0	0
LARP4B	23185	broad.mit.edu	37	10	863817	863817	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr10:863817G>A	uc001ifs.1	-	14	1584	c.1543C>T	c.(1543-1545)CAG>TAG	p.Q515*		NM_015155	NP_055970	Q92615	LAR4B_HUMAN	La ribonucleoprotein domain family, member 4B	515							nucleotide binding|RNA binding			ovary(2)|central_nervous_system(1)	3						GTTGGAGACTGTGTCTGGCTG	0.557		NA											23	49					0	0	0	0
IL2RA	3559	broad.mit.edu	37	10	6061875	6061875	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr10:6061875C>T	uc001iiz.1	-	5	772	c.613G>A	c.(613-615)GGC>AGC	p.G205S	IL2RA_uc009xih.1_Missense_Mutation_p.G133S|IL2RA_uc001ija.1_Intron	NM_000417	NP_000408	P01589	IL2RA_HUMAN	interleukin 2 receptor, alpha chain precursor	205	Extracellular (Potential).				cell proliferation	integral to membrane	interleukin-2 receptor activity			ovary(1)|skin(1)	2					Aldesleukin(DB00041)|Basiliximab(DB00074)|Daclizumab(DB00111)|Denileukin diftitox(DB00004)	TCAGGACGGCCTTCGGGGCTT	0.597		NA											30	59					0	0	0	0
MCM10	55388	broad.mit.edu	37	10	13240697	13240697	+	Nonsense_Mutation	SNP	G	G	T			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr10:13240697G>T	uc001ima.2	+	16	2232	c.2131G>T	c.(2131-2133)GAA>TAA	p.E711*	MCM10_uc001imb.2_Nonsense_Mutation_p.E710*|MCM10_uc001imc.2_Nonsense_Mutation_p.E710*	NM_182751	NP_877428	Q7L590	MCM10_HUMAN	minichromosome maintenance complex component 10	711					cell cycle checkpoint|DNA replication|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle	nucleoplasm	metal ion binding|protein binding			ovary(2)|central_nervous_system(1)	3						AGCTGAGGATGAATTGGAGCC	0.458		NA											45	61					8.94e-30	1.19e-29	1	0
NPFFR1	64106	broad.mit.edu	37	10	72020461	72020461	+	Silent	SNP	G	G	A			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr10:72020461G>A	uc010qjk.1	-	2	357	c.351C>T	c.(349-351)AGC>AGT	p.S117S		NM_022146	NP_071429	Q9GZQ6	NPFF1_HUMAN	neuropeptide FF receptor 1	119	Helical; Name=3; (Potential).					integral to membrane|plasma membrane	neuropeptide receptor activity				0						GCACCAAGCCGCTCATCTTGC	0.532		NA											7	17					0	0	0	0
KIAA0913	23053	broad.mit.edu	37	10	75552076	75552076	+	Missense_Mutation	SNP	T	T	A			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr10:75552076T>A	uc009xrl.2	+	10	1811	c.1779T>A	c.(1777-1779)AGT>AGA	p.S593R	KIAA0913_uc001jve.2_Missense_Mutation_p.S593R|KIAA0913_uc001jvf.2_Missense_Mutation_p.S593R|KIAA0913_uc001jvh.2_RNA|KIAA0913_uc001jvi.2_Missense_Mutation_p.S16R|KIAA0913_uc010qkr.1_Missense_Mutation_p.S16R|KIAA0913_uc001jvj.2_Missense_Mutation_p.S16R	NM_015037	NP_055852	A7E2V4	K0913_HUMAN	hypothetical protein LOC23053	593	Gly-rich.						zinc ion binding			breast(1)	1	Prostate(51;0.0112)					GGGCTGGCAGTGGGAGCAAGG	0.642		NA											13	17					0	0	0	0
LIPN	643418	broad.mit.edu	37	10	90521213	90521213	+	Silent	SNP	T	T	C			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr10:90521213T>C	uc010qmw.1	+	1	51	c.51T>C	c.(49-51)AAT>AAC	p.N17N		NM_001102469	NP_001095939	Q5VXI9	LIPN_HUMAN	lipase-like, ab-hydrolase domain containing 4	17					lipid catabolic process	extracellular region	hydrolase activity				0		Colorectal(252;0.0161)		Colorectal(12;4.83e-05)|COAD - Colon adenocarcinoma(12;6.5e-05)		GAACTTTAAATGCTGGTGGAT	0.343		NA											39	62					0	0	0	0
TLX1	3195	broad.mit.edu	37	10	102891411	102891411	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr10:102891411C>G	uc001ksw.2	+	1	351	c.113C>G	c.(112-114)TCG>TGG	p.S38W	TLX1NB_uc001ksv.2_5'Flank	NM_005521	NP_005512	P31314	TLX1_HUMAN	T-cell leukemia homeobox 1	38						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)	1				Epithelial(162;6.35e-09)|all cancers(201;3.21e-07)		GGACCCGCCTCGCGCCTCCAG	0.706		NA	T	TRB@|TRD@	T-ALL								8	15					0	0	0	0
ACSL5	51703	broad.mit.edu	37	10	114158684	114158684	+	Missense_Mutation	SNP	A	A	G			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr10:114158684A>G	uc001kzs.2	+	3	323	c.182A>G	c.(181-183)CAG>CGG	p.Q61R	ACSL5_uc001kzt.2_Missense_Mutation_p.Q61R|ACSL5_uc001kzu.2_Missense_Mutation_p.Q117R|ACSL5_uc009xxz.2_Missense_Mutation_p.Q61R	NM_203379	NP_976313	Q9ULC5	ACSL5_HUMAN	acyl-CoA synthetase long-chain family member 5	61	Cytoplasmic (Potential).				fatty acid metabolic process|long-chain fatty-acyl-CoA biosynthetic process|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane|mitochondrial outer membrane	ATP binding|long-chain fatty acid-CoA ligase activity			large_intestine(2)|skin(1)	3		Colorectal(252;0.117)|Breast(234;0.222)		Epithelial(162;0.0343)|all cancers(201;0.137)		GGGGTTTCCCAGAAGAACAAT	0.463		NA											55	73					0	0	0	0
ACSL5	51703	broad.mit.edu	37	10	114171725	114171725	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr10:114171725G>C	uc001kzs.2	+	11	1077	c.936G>C	c.(934-936)GAG>GAC	p.E312D	ACSL5_uc001kzt.2_Missense_Mutation_p.E312D|ACSL5_uc001kzu.2_Missense_Mutation_p.E368D|ACSL5_uc009xxz.2_Missense_Mutation_p.E312D|ACSL5_uc010qrj.1_Missense_Mutation_p.E94D	NM_203379	NP_976313	Q9ULC5	ACSL5_HUMAN	acyl-CoA synthetase long-chain family member 5	312	Cytoplasmic (Potential).				fatty acid metabolic process|long-chain fatty-acyl-CoA biosynthetic process|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane|mitochondrial outer membrane	ATP binding|long-chain fatty acid-CoA ligase activity			large_intestine(2)|skin(1)	3		Colorectal(252;0.117)|Breast(234;0.222)		Epithelial(162;0.0343)|all cancers(201;0.137)		ATATGTTTGAGAGGATTGTAC	0.478		NA											7	139					0	0	0	0
NLRP14	338323	broad.mit.edu	37	11	7063670	7063670	+	Missense_Mutation	SNP	G	G	T			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr11:7063670G>T	uc001mfb.1	+	4	736	c.413G>T	c.(412-414)TGG>TTG	p.W138L		NM_176822	NP_789792	Q86W24	NAL14_HUMAN	NLR family, pyrin domain containing 14	138					cell differentiation|multicellular organismal development|spermatogenesis		ATP binding			ovary(3)|breast(2)|pancreas(1)|lung(1)|skin(1)	8				Epithelial(150;4.62e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0871)		TGCATCACTTGGGACAAGAAG	0.363		NA											30	16					1.4e-14	1.81e-14	1	0
OR10A6	390093	broad.mit.edu	37	11	7950014	7950014	+	Missense_Mutation	SNP	A	A	C			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr11:7950014A>C	uc010rbh.1	-	1	196	c.196T>G	c.(196-198)TTA>GTA	p.L66V		NM_001004461	NP_001004461	Q8NH74	O10A6_HUMAN	olfactory receptor, family 10, subfamily A,	66	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2				Epithelial(150;1.38e-07)|BRCA - Breast invasive adenocarcinoma(625;0.189)		ACCACAGATAAGTTCAGGAGA	0.443		NA											61	29					0	0	0	0
NAV2	89797	broad.mit.edu	37	11	19970445	19970445	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr11:19970445G>A	uc010rdm.1	+	11	2894	c.2533G>A	c.(2533-2535)GTG>ATG	p.V845M	NAV2_uc001mpp.2_Missense_Mutation_p.V758M|NAV2_uc001mpr.3_Missense_Mutation_p.V822M	NM_145117	NP_660093	Q8IVL1	NAV2_HUMAN	neuron navigator 2 isoform 2	845						nucleus	ATP binding|helicase activity			skin(4)|ovary(1)|pancreas(1)	6						AGGTCGCTATGTGTACTCCGC	0.612		NA											40	14					0	0	0	0
RAG2	5897	broad.mit.edu	37	11	36614509	36614509	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr11:36614509C>T	uc001mwv.3	-	2	1398	c.1210G>A	c.(1210-1212)GAA>AAA	p.E404K	RAG1_uc001mwt.2_Intron|C11orf74_uc010rfd.1_5'Flank|C11orf74_uc001mww.1_5'Flank|C11orf74_uc001mwx.1_5'Flank|C11orf74_uc001mwy.1_5'Flank|C11orf74_uc001mwz.1_5'Flank|C11orf74_uc010rfe.1_5'Flank	NM_000536	NP_000527	P55895	RAG2_HUMAN	recombination activating gene 2	404					chromatin modification|pre-B cell allelic exclusion|somatic diversification of immunoglobulins|T cell differentiation in thymus|V(D)J recombination	nucleus	chromatin binding|DNA binding|endonuclease activity|methylated histone residue binding|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-4,5-bisphosphate binding|zinc ion binding			skin(3)|ovary(1)|pancreas(1)	5	all_lung(20;0.226)	all_hematologic(20;0.00756)				TCATCATCTTCATTATAGGTG	0.403		NA							Familial_Hemophagocytic_Lymphohistiocytosis				38	24					0	0	0	0
FAM111B	374393	broad.mit.edu	37	11	58892341	58892341	+	Missense_Mutation	SNP	T	T	A			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr11:58892341T>A	uc001nnl.2	+	4	1014	c.771T>A	c.(769-771)GAT>GAA	p.D257E	FAM111B_uc001nnm.2_Missense_Mutation_p.D227E|FAM111B_uc010rko.1_Missense_Mutation_p.D227E	NM_198947	NP_945185	Q6SJ93	F111B_HUMAN	hypothetical protein LOC374393 isoform a	257							catalytic activity			ovary(2)	2						CCATGGTGGATGAAGTATCTG	0.343		NA											4	31					0	0	0	0
B3GAT3	26229	broad.mit.edu	37	11	62384617	62384617	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr11:62384617G>A	uc001ntw.2	-	3	489	c.460C>T	c.(460-462)CAT>TAT	p.H154Y	B3GAT3_uc009ynz.2_Missense_Mutation_p.H147Y|B3GAT3_uc001ntx.2_RNA|B3GAT3_uc010rlz.1_Missense_Mutation_p.H154Y	NM_012200	NP_036332	O94766	B3GA3_HUMAN	beta-1,3-glucuronyltransferase 3	154	Lumenal (Potential).				glycosaminoglycan biosynthetic process	Golgi membrane|integral to membrane	galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity|manganese ion binding				0						CCACGGGGATGAACCCAGCCA	0.687		NA											33	46					0	0	0	0
TM7SF2	7108	broad.mit.edu	37	11	64883456	64883456	+	Silent	SNP	G	G	A			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr11:64883456G>A	uc001oct.2	+	10	1335	c.1188G>A	c.(1186-1188)CAG>CAA	p.Q396Q	TM7SF2_uc010rny.1_Silent_p.Q280Q|TM7SF2_uc001ocu.2_Silent_p.Q369Q|TM7SF2_uc001ocv.2_Silent_p.Q417Q|uc009yqb.1_5'Flank	NM_003273	NP_003264	O76062	ERG24_HUMAN	transmembrane 7 superfamily member 2	396					cholesterol biosynthetic process	endoplasmic reticulum membrane|integral to plasma membrane	delta14-sterol reductase activity			ovary(1)	1						AGTGCCTGCAGAAGTACGGCC	0.632		NA											21	32					0	0	0	0
RAB1B	81876	broad.mit.edu	37	11	66039643	66039643	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr11:66039643G>C	uc001ohf.2	+	3	198	c.103G>C	c.(103-105)GAG>CAG	p.E35Q	uc001ohg.1_RNA	NM_030981	NP_112243	Q9H0U4	RAB1B_HUMAN	RAB1B, member RAS oncogene family	35					protein transport|small GTPase mediated signal transduction	Golgi apparatus|membrane	GTP binding|protein binding				0						CACGTACACAGAGAGCTACAT	0.527		NA											74	150					0	0	0	0
TCIRG1	10312	broad.mit.edu	37	11	67816400	67816400	+	Missense_Mutation	SNP	A	A	T			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr11:67816400A>T	uc001one.2	+	14	1717	c.1609A>T	c.(1609-1611)ATG>TTG	p.M537L	TCIRG1_uc001ong.2_Missense_Mutation_p.M321L|TCIRG1_uc001onh.2_Missense_Mutation_p.M239L|TCIRG1_uc001oni.2_Missense_Mutation_p.M41L|TCIRG1_uc009ysd.2_5'Flank	NM_006019	NP_006010	Q13488	VPP3_HUMAN	T-cell, immune regulator 1 isoform a	537	Lumenal (Potential).				ATP hydrolysis coupled proton transport|cellular defense response|cellular iron ion homeostasis|insulin receptor signaling pathway|positive regulation of cell proliferation|transferrin transport	apical plasma membrane|endosome membrane|integral to plasma membrane|proton-transporting two-sector ATPase complex, proton-transporting domain	hydrogen ion transmembrane transporter activity			ovary(1)	1						CAAGATGAAGATGTCCGTCAT	0.632		NA											62	86					0	0	0	0
NAALAD2	10003	broad.mit.edu	37	11	89902099	89902099	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr11:89902099G>C	uc001pdf.3	+	12	1390	c.1281G>C	c.(1279-1281)GAG>GAC	p.E427D	NAALAD2_uc009yvx.2_Missense_Mutation_p.E394D|NAALAD2_uc009yvy.2_Intron	NM_005467	NP_005458	Q9Y3Q0	NALD2_HUMAN	N-acetylated alpha-linked acidic dipeptidase 2	427	Extracellular (Potential).|NAALADase.				proteolysis	integral to membrane	carboxypeptidase activity|dipeptidase activity|dipeptidyl-peptidase activity|metal ion binding|metallopeptidase activity|serine-type peptidase activity			pancreas(1)|skin(1)	2		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00556)				AACTACAGGAGAATGTCAAAA	0.303		NA											12	42					0	0	0	0
CNTN5	53942	broad.mit.edu	37	11	100211833	100211833	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr11:100211833C>G	uc001pga.2	+	23	3265	c.2926C>G	c.(2926-2928)CAA>GAA	p.Q976E	CNTN5_uc001pgb.2_Missense_Mutation_p.Q902E|CNTN5_uc010ruk.1_Missense_Mutation_p.Q247E	NM_014361	NP_055176	O94779	CNTN5_HUMAN	contactin 5 isoform long	976	Fibronectin type-III 4.				cell adhesion	anchored to membrane|plasma membrane	protein binding			skin(3)|ovary(2)|pancreas(2)|breast(1)	8		all_hematologic(158;1.22e-05)|Acute lymphoblastic leukemia(157;3.81e-05)|Melanoma(852;0.219)		BRCA - Breast invasive adenocarcinoma(274;0.00146)|KIRC - Kidney renal clear cell carcinoma(183;0.156)|Kidney(183;0.196)		AGCTCCTAGTCAAGCACCTAG	0.428		NA											4	110					0	0	0	0
DYNC2H1	79659	broad.mit.edu	37	11	102993566	102993566	+	Missense_Mutation	SNP	A	A	C			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr11:102993566A>C	uc001pho.2	+	11	1642	c.1498A>C	c.(1498-1500)ATC>CTC	p.I500L	DYNC2H1_uc001phn.1_Missense_Mutation_p.I500L|DYNC2H1_uc009yxe.1_Missense_Mutation_p.I500L	NM_001080463	NP_001073932	Q8NCM8	DYHC2_HUMAN	dynein, cytoplasmic 2, heavy chain 1	500	Stem (By similarity).				cell projection organization|Golgi organization|microtubule-based movement|multicellular organismal development	cilium axoneme|dynein complex|Golgi apparatus|microtubule|plasma membrane	ATP binding|ATPase activity|microtubule motor activity				0		Acute lymphoblastic leukemia(157;0.000966)|all_hematologic(158;0.00348)		BRCA - Breast invasive adenocarcinoma(274;0.000177)|Epithelial(105;0.0785)		AGATGATACTATCAAGATTGC	0.358		NA											15	25					0	0	0	0
BSX	390259	broad.mit.edu	37	11	122850009	122850009	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr11:122850009C>T	uc010rzs.1	-	2	419	c.419G>A	c.(418-420)CGA>CAA	p.R140Q		NM_001098169	NP_001091639	Q3C1V8	BSH_HUMAN	brain specific homeobox	140	Homeobox.										0		Breast(109;0.00249)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0361)		CAGCTCCACTCGTTCTGGCGT	0.637		NA											42	97					0	0	0	0
FGF23	8074	broad.mit.edu	37	12	4479837	4479837	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr12:4479837C>G	uc001qmq.1	-	3	574	c.428G>C	c.(427-429)AGA>ACA	p.R143T		NM_020638	NP_065689	Q9GZV9	FGF23_HUMAN	fibroblast growth factor 23 precursor	143					cell differentiation|insulin receptor signaling pathway|negative regulation of bone mineralization|negative regulation of hormone secretion|negative regulation of osteoblast differentiation|positive regulation of vitamin D 24-hydroxylase activity|regulation of phosphate transport|vitamin D catabolic process	extracellular space	growth factor activity			ovary(2)|breast(1)|skin(1)	4			Colorectal(7;0.00165)|COAD - Colon adenocarcinoma(12;0.0229)|STAD - Stomach adenocarcinoma(119;0.206)			CAGGAAGGCTCTCTTCGCCCG	0.597		NA											68	110					0	0	0	0
GDF3	9573	broad.mit.edu	37	12	7842556	7842556	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr12:7842556G>A	uc001qte.2	-	2	1049	c.1013C>T	c.(1012-1014)TCC>TTC	p.S338F		NM_020634	NP_065685	Q9NR23	GDF3_HUMAN	growth differentiation factor 3 precursor	338					eye development|growth|skeletal system development	extracellular space	cytokine activity|growth factor activity			skin(3)|ovary(1)|lung(1)|central_nervous_system(1)	6						GTAGAGCATGGAAATGGGAGA	0.478		NA											30	59					0	0	0	0
TMPRSS12	283471	broad.mit.edu	37	12	51281127	51281127	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr12:51281127G>A	uc001rwx.3	+	5	925	c.878G>A	c.(877-879)GGC>GAC	p.G293D	TMPRSS12_uc001rwy.2_3'UTR	NM_182559	NP_872365	Q86WS5	TMPSC_HUMAN	transmembrane protease, serine 12 precursor	293	Peptidase S1.|Extracellular (Potential).				proteolysis	integral to membrane	serine-type endopeptidase activity				0						TACGGACATGGCTGTGGTCGA	0.433		NA											53	73					0	0	0	0
KRT76	51350	broad.mit.edu	37	12	53164843	53164843	+	Missense_Mutation	SNP	T	T	G			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr12:53164843T>G	uc001sax.2	-	7	1478	c.1424A>C	c.(1423-1425)AAG>ACG	p.K475T		NM_015848	NP_056932	Q01546	K22O_HUMAN	keratin 76	475	Rod.|Coil 2.				cytoskeleton organization	keratin filament	structural molecule activity			breast(1)|skin(1)	2						CAGGGCCAGCTTGACGTTCAT	0.572		NA											9	116					0	0	0	0
OR6C75	390323	broad.mit.edu	37	12	55759093	55759093	+	Silent	SNP	C	C	T			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr12:55759093C>T	uc010spk.1	+	1	199	c.199C>T	c.(199-201)CTG>TTG	p.L67L		NM_001005497	NP_001005497	A6NL08	O6C75_HUMAN	olfactory receptor, family 6, subfamily C,	67	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|large_intestine(1)	3						CTTCTCATTCCTGGAAATTTC	0.443		NA											81	119					0	0	0	0
LRP1	4035	broad.mit.edu	37	12	57594938	57594938	+	Splice_Site	SNP	T	T	C	rs111522273		TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr12:57594938T>C	uc001snd.2	+	65	10811	c.10345_splice	c.e65+2	p.P3449_splice		NM_002332	NP_002323	Q07954	LRP1_HUMAN	low density lipoprotein-related protein 1						aorta morphogenesis|apoptotic cell clearance|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of Wnt receptor signaling pathway|positive regulation of cholesterol efflux|regulation of actin cytoskeleton organization|regulation of phospholipase A2 activity	coated pit|integral to plasma membrane|nucleus	apolipoprotein E binding|calcium ion binding|lipoprotein transporter activity|protein complex binding|receptor activity			ovary(8)|lung(3)|breast(3)|large_intestine(2)|central_nervous_system(2)|skin(2)|pancreas(2)	22				BRCA - Breast invasive adenocarcinoma(357;0.0103)	Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Becaplermin(DB00102)|Coagulation Factor IX(DB00100)|Tenecteplase(DB00031)	GGGACTGCCGTGAGTGTCAGA	0.567		NA											45	84					0	0	0	0
HELB	92797	broad.mit.edu	37	12	66725387	66725387	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr12:66725387G>C	uc001sti.2	+	12	3152	c.3124G>C	c.(3124-3126)GGT>CGT	p.G1042R	HELB_uc010ssz.1_RNA|HELB_uc009zqt.1_RNA	NM_033647	NP_387467	Q8NG08	HELB_HUMAN	helicase (DNA) B	1042					DNA replication, synthesis of RNA primer		ATP binding|ATP-dependent 5'-3' DNA helicase activity|single-stranded DNA-dependent ATP-dependent DNA helicase activity			central_nervous_system(1)|pancreas(1)	2			GBM - Glioblastoma multiforme(2;0.000142)	GBM - Glioblastoma multiforme(28;0.0265)		AAGAACCTGTGGTGTGAATGA	0.388		NA											5	160					0	0	0	0
IL22	50616	broad.mit.edu	37	12	68645319	68645319	+	Missense_Mutation	SNP	G	G	T			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr12:68645319G>T	uc001sty.1	-	4	489	c.436C>A	c.(436-438)CAA>AAA	p.Q146K	IL22_uc010stb.1_Missense_Mutation_p.Q146K	NM_020525	NP_065386	Q9GZX6	IL22_HUMAN	interleukin 22 precursor	146					acute-phase response	extracellular space	cytokine activity|interleukin-22 receptor binding				0		Myeloproliferative disorder(1001;0.0255)	Lung(24;0.000131)|LUAD - Lung adenocarcinoma(15;0.00107)|STAD - Stomach adenocarcinoma(21;0.018)	GBM - Glioblastoma multiforme(7;5.06e-05)|BRCA - Breast invasive adenocarcinoma(357;0.00104)		TTCAGCTTTTGCACATTCCTC	0.363		NA											23	134					3.74e-20	4.95e-20	1	0
MDM1	56890	broad.mit.edu	37	12	68719244	68719244	+	Missense_Mutation	SNP	C	C	A	rs138314442		TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr12:68719244C>A	uc001stz.2	-	4	746	c.610G>T	c.(610-612)GCT>TCT	p.A204S	MDM1_uc010stc.1_Intron|MDM1_uc009zqv.1_5'UTR|MDM1_uc001sua.3_3'UTR|MDM1_uc010std.1_3'UTR	NM_017440	NP_059136	Q8TC05	MDM1_HUMAN	mouse Mdm1 nuclear protein homolog isoform 1	204						nucleus				ovary(3)|skin(2)	5			Lung(24;0.000131)|LUAD - Lung adenocarcinoma(15;0.00107)|STAD - Stomach adenocarcinoma(21;0.018)	GBM - Glioblastoma multiforme(7;0.000174)		AAAGCTGGAGCAGTTTCTTTA	0.348		NA											103	380					2.98e-41	4.04e-41	1	0
GALNT4	8693	broad.mit.edu	37	12	89917406	89917406	+	Silent	SNP	A	A	T			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr12:89917406A>T	uc001tbd.2	-	1	1130	c.921T>A	c.(919-921)CCT>CCA	p.P307P	POC1B_uc001tba.2_Intron|POC1B_uc001tbb.2_Intron|POC1B_uc001tbc.2_Intron|POC1B_uc010sun.1_Intron|GALNT4_uc001tbe.2_Silent_p.P304P|GALNT4_uc010suo.1_5'UTR	NM_003774	NP_003765	Q8N4A0	GALT4_HUMAN	polypeptide N-acetylgalactosaminyltransferase 4	307	Catalytic subdomain B.|Lumenal (Potential).				carbohydrate metabolic process	Golgi membrane|integral to membrane|perinuclear region of cytoplasm	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding				0						CAGCCATGGTAGGTGATCTGA	0.473		NA											7	79					0	0	0	0
STAB2	55576	broad.mit.edu	37	12	104118864	104118864	+	Missense_Mutation	SNP	A	A	T			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr12:104118864A>T	uc001tjw.2	+	45	4981	c.4795A>T	c.(4795-4797)ATT>TTT	p.I1599F	STAB2_uc009zug.2_RNA	NM_017564	NP_060034	Q8WWQ8	STAB2_HUMAN	stabilin 2 precursor	1599	Extracellular (Potential).|FAS1 5.			IY -> HE (in Ref. 7; AAF82398).	angiogenesis|cell adhesion|defense response to bacterium|receptor-mediated endocytosis	cytoplasm|external side of plasma membrane|integral to plasma membrane	Gram-negative bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			ovary(9)|skin(5)	14						CCGCGGCAGCATTTATCAGGT	0.438		NA											67	16					0	0	0	0
GLT8D2	83468	broad.mit.edu	37	12	104390557	104390557	+	Missense_Mutation	SNP	C	C	T	rs7133444		TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr12:104390557C>T	uc001tkh.1	-	8	962	c.556G>A	c.(556-558)GAT>AAT	p.D186N	GLT8D2_uc001tki.1_Missense_Mutation_p.D186N	NM_031302	NP_112592	Q9H1C3	GL8D2_HUMAN	glycosyltransferase 8 domain containing 2	186	Lumenal (Potential).					integral to membrane	transferase activity, transferring glycosyl groups			ovary(1)|skin(1)	2						GAGGGCAAATCGCAGTCATCT	0.502		NA											59	19					0	0	0	0
C12orf51	283450	broad.mit.edu	37	12	112665943	112665943	+	Silent	SNP	C	C	T			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr12:112665943C>T	uc009zwc.2	-	36	5556	c.5538G>A	c.(5536-5538)GGG>GGA	p.G1846G	C12orf51_uc001ttr.1_Silent_p.G21G	NM_001109662	NP_001103132			chromosome 12 open reading frame 51											ovary(1)|lung(1)	2						CAGGAGCTGACCCATCTCCTG	0.517		NA											43	22					0	0	0	0
CDK8	1024	broad.mit.edu	37	13	26975692	26975692	+	Silent	SNP	G	G	A	rs138501276		TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr13:26975692G>A	uc001uqr.1	+	12	1226	c.1200G>A	c.(1198-1200)CCG>CCA	p.P400P	CDK8_uc001uqs.1_Silent_p.P399P|CDK8_uc001uqt.1_Silent_p.P227P	NM_001260	NP_001251	P49336	CDK8_HUMAN	cyclin-dependent kinase 8	400					regulation of transcription, DNA-dependent|transcription, DNA-dependent	mediator complex	ATP binding|cyclin-dependent protein kinase activity|protein binding|RNA polymerase II carboxy-terminal domain kinase activity			lung(2)|large_intestine(1)|ovary(1)|skin(1)	5	Colorectal(5;0.000442)	Lung SC(185;0.0156)|Breast(139;0.147)		all cancers(112;0.0384)|Epithelial(112;0.142)|OV - Ovarian serous cystadenocarcinoma(117;0.188)		AGGGACCCCCGTTGAAGAAAG	0.473		NA											7	47					0	0	0	0
MYCBP2	23077	broad.mit.edu	37	13	77671556	77671556	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr13:77671556C>G	uc001vkf.2	-	57	9710	c.9619G>C	c.(9619-9621)GGG>CGG	p.G3207R	MYCBP2_uc010aev.2_Missense_Mutation_p.G2611R|MYCBP2_uc001vkg.1_Missense_Mutation_p.G730R	NM_015057	NP_055872	O75592	MYCB2_HUMAN	MYC binding protein 2	3207					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ligase activity|protein binding|zinc ion binding			ovary(4)|breast(4)|skin(3)|lung(2)|pancreas(1)	14		Breast(118;0.212)|Acute lymphoblastic leukemia(28;0.22)		GBM - Glioblastoma multiforme(99;0.109)		TGTGACTCCCCACACAGTTCA	0.423		NA											14	29					0	0	0	0
SLITRK5	26050	broad.mit.edu	37	13	88327892	88327892	+	Silent	SNP	C	C	T			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr13:88327892C>T	uc001vln.2	+	2	468	c.249C>T	c.(247-249)ATC>ATT	p.I83I	SLITRK5_uc010tic.1_Intron	NM_015567	NP_056382	O94991	SLIK5_HUMAN	SLIT and NTRK-like family, member 5 precursor	83	LRR 1.|Extracellular (Potential).					integral to membrane				ovary(2)|pancreas(2)|central_nervous_system(1)	5	all_neural(89;0.101)|Medulloblastoma(90;0.163)					GTTTCCCAATCTACCACCTCT	0.453		NA											84	138					0	0	0	0
F10	2159	broad.mit.edu	37	13	113777199	113777199	+	Silent	SNP	C	C	T			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr13:113777199C>T	uc001vsx.2	+	1	87	c.30C>T	c.(28-30)CTC>CTT	p.L10L	F10_uc010agq.1_RNA|F10_uc001vsy.2_Silent_p.L10L|F10_uc001vsz.2_Silent_p.L10L	NM_000504	NP_000495	P00742	FA10_HUMAN	coagulation factor X preproprotein	10					blood coagulation, extrinsic pathway|blood coagulation, intrinsic pathway|peptidyl-glutamic acid carboxylation|positive regulation of cell migration|positive regulation of protein kinase B signaling cascade|post-translational protein modification|proteolysis	endoplasmic reticulum lumen|extracellular region|Golgi lumen	calcium ion binding|phospholipid binding|protein binding|serine-type endopeptidase activity			pancreas(1)	1	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)	all_cancers(25;0.113)|all_lung(25;0.0364)|all_epithelial(44;0.0373)|Lung NSC(25;0.128)|Breast(118;0.188)	all cancers(43;0.0805)|Epithelial(84;0.231)		Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Coagulation factor VIIa(DB00036)|Enoxaparin(DB01225)|Heparin(DB01109)|Menadione(DB00170)|Reteplase(DB00015)|Tenecteplase(DB00031)	TCGTCCTGCTCAGTGCCTCCC	0.672		NA											12	25					0	0	0	0
AP1G2	8906	broad.mit.edu	37	14	24034829	24034829	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr14:24034829C>T	uc001wkl.2	-	7	1064	c.727G>A	c.(727-729)GAC>AAC	p.D243N	AP1G2_uc001wkj.2_5'UTR|AP1G2_uc001wkk.3_Missense_Mutation_p.D171N|AP1G2_uc001wkn.2_5'UTR|uc001wko.1_RNA|AP1G2_uc001wkp.1_5'Flank|AP1G2_uc010tnp.1_Missense_Mutation_p.D243N|AP1G2_uc010aks.2_Missense_Mutation_p.D171N|AP1G2_uc010akt.2_Missense_Mutation_p.D171N|AP1G2_uc010tnq.1_RNA	NM_003917	NP_003908	O75843	AP1G2_HUMAN	adaptor-related protein complex 1, gamma 2	243					interspecies interaction between organisms|intracellular protein transport|vesicle-mediated transport	AP-1 adaptor complex|endosome membrane	protein binding|protein transporter activity			ovary(1)	1	all_cancers(95;0.000251)			GBM - Glioblastoma multiforme(265;0.00672)		AGGAAGGGGTCGCTGACTCCA	0.557		NA											16	31					0	0	0	0
NYNRIN	57523	broad.mit.edu	37	14	24884134	24884134	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr14:24884134C>T	uc001wpf.3	+	9	3497	c.3179C>T	c.(3178-3180)GCA>GTA	p.A1060V		NM_025081	NP_079357	Q9P2P1	NYNRI_HUMAN	hypothetical protein LOC57523	1060					DNA integration	integral to membrane	DNA binding			ovary(2)|central_nervous_system(1)	3						CTGCCAGGGGCAGCTTCTCCC	0.647		NA											9	121					0	0	0	0
KLHL28	54813	broad.mit.edu	37	14	45414307	45414307	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr14:45414307C>T	uc001wvq.2	-	2	1071	c.825G>A	c.(823-825)ATG>ATA	p.M275I	KLHL28_uc001wvr.2_Missense_Mutation_p.M275I|KLHL28_uc001wvt.3_Missense_Mutation_p.M275I	NM_017658	NP_060128	Q9NXS3	KLH28_HUMAN	BTB (POZ) domain containing 5	275										ovary(1)	1						GAGGTCGTGTCATCAAGACTG	0.418		NA											50	65					0	0	0	0
SOS2	6655	broad.mit.edu	37	14	50616839	50616839	+	Silent	SNP	T	T	A			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr14:50616839T>A	uc001wxs.3	-	14	2369	c.2271A>T	c.(2269-2271)CCA>CCT	p.P757P	SOS2_uc010tql.1_Silent_p.P724P|SOS2_uc010tqm.1_RNA	NM_006939	NP_008870	Q07890	SOS2_HUMAN	son of sevenless homolog 2	757	Poly-Pro.				apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	DNA binding|protein binding|Rho guanyl-nucleotide exchange factor activity			ovary(2)	2	all_epithelial(31;0.000822)|Breast(41;0.0065)					ATTCAATTGGTGGAGGTGGAC	0.408		NA											50	94					0	0	0	0
SYNE2	23224	broad.mit.edu	37	14	64518544	64518544	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr14:64518544C>G	uc001xgm.2	+	48	8143	c.7913C>G	c.(7912-7914)ACT>AGT	p.T2638S	SYNE2_uc001xgl.2_Missense_Mutation_p.T2638S	NM_015180	NP_055995	Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	2638	Potential.|Cytoplasmic (Potential).				centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			ovary(8)|breast(4)|central_nervous_system(1)|pancreas(1)	14				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		GTACAGGACACTGAGATTTCT	0.448		NA											14	99					0	0	0	0
MTHFD1	4522	broad.mit.edu	37	14	64891551	64891551	+	Missense_Mutation	SNP	G	G	T			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr14:64891551G>T	uc001xhb.2	+	9	1144	c.757G>T	c.(757-759)GTG>TTG	p.V253L	MTHFD1_uc010aqe.2_Missense_Mutation_p.V289L|MTHFD1_uc010aqf.2_Missense_Mutation_p.V309L	NM_005956	NP_005947	P11586	C1TC_HUMAN	methylenetetrahydrofolate dehydrogenase 1	253	Methylenetetrahydrofolate dehydrogenase and cyclohydrolase.				folic acid metabolic process|folic acid-containing compound biosynthetic process|histidine biosynthetic process|methionine biosynthetic process|one-carbon metabolic process|purine nucleotide biosynthetic process	cytosol|mitochondrion	ATP binding|formate-tetrahydrofolate ligase activity|methenyltetrahydrofolate cyclohydrolase activity|methylenetetrahydrofolate dehydrogenase (NADP+) activity|methylenetetrahydrofolate dehydrogenase|protein binding			ovary(2)	2				OV - Ovarian serous cystadenocarcinoma(108;8.7e-12)|all cancers(60;3.29e-11)|BRCA - Breast invasive adenocarcinoma(234;0.0488)	NADH(DB00157)|Tetrahydrofolic acid(DB00116)	GAGAAAAGTTGTGGGTGATGT	0.488		NA											4	38					1.24e-05	1.5e-05	1	0
ARG2	384	broad.mit.edu	37	14	68108986	68108986	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr14:68108986C>T	uc001xjs.2	+	3	384	c.268C>T	c.(268-270)CGC>TGC	p.R90C		NM_001172	NP_001163	P78540	ARGI2_HUMAN	arginase 2 precursor	90					arginine metabolic process|nitric oxide biosynthetic process|urea cycle	mitochondrial matrix	arginase activity|metal ion binding				0				all cancers(60;0.000582)|OV - Ovarian serous cystadenocarcinoma(108;0.00392)|BRCA - Breast invasive adenocarcinoma(234;0.00928)	L-Arginine(DB00125)|L-Ornithine(DB00129)	AGTGAATCCACGCTCAGTGGG	0.507		NA											24	31					0	0	0	0
TMEM90A	646658	broad.mit.edu	37	14	74874373	74874373	+	Silent	SNP	C	C	T			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr14:74874373C>T	uc001xpx.2	-	4	830	c.582G>A	c.(580-582)GGG>GGA	p.G194G		NM_001105579	NP_001099049	A6NDD5	SYN1L_HUMAN	transmembrane protein 90A	194					response to biotic stimulus	Golgi apparatus|integral to membrane					0				BRCA - Breast invasive adenocarcinoma(234;0.00159)		GGCGGAAGTCCCCTTTGGAGA	0.662		NA											33	69					0	0	0	0
CCDC88C	440193	broad.mit.edu	37	14	91787565	91787565	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr14:91787565G>A	uc010aty.2	-	13	1525	c.1426C>T	c.(1426-1428)CAG>TAG	p.Q476*		NM_001080414	NP_001073883	Q9P219	DAPLE_HUMAN	DVL-binding protein DAPLE	476	Potential.				microtubule cytoskeleton organization|protein destabilization|protein homooligomerization|regulation of protein phosphorylation|Wnt receptor signaling pathway	cytoplasm|insoluble fraction	microtubule binding|PDZ domain binding|protein self-association			ovary(3)	3		all_cancers(154;0.0468)				ATGGTGCTCTGGAGGCTCTGA	0.587		NA											8	14					0	0	0	0
PPP4R4	57718	broad.mit.edu	37	14	94722876	94722876	+	Nonsense_Mutation	SNP	G	G	T			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr14:94722876G>T	uc001ycs.1	+	17	2099	c.1945G>T	c.(1945-1947)GAA>TAA	p.E649*		NM_058237	NP_478144	Q6NUP7	PP4R4_HUMAN	HEAT-like repeat-containing protein isoform 1	649						cytoplasm|protein serine/threonine phosphatase complex	protein binding			skin(3)|upper_aerodigestive_tract(1)	4						TCAGCAGTTAGAAATGTGTGT	0.348		NA											5	26					0.000602214	0.000698526	1	0
HHIPL1	84439	broad.mit.edu	37	14	100125954	100125954	+	Silent	SNP	C	C	T			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr14:100125954C>T	uc010avs.2	+	4	1301	c.1236C>T	c.(1234-1236)CGC>CGT	p.R412R	HHIPL1_uc001ygl.1_Silent_p.R412R	NM_001127258	NP_001120730	Q96JK4	HIPL1_HUMAN	HHIP-like protein 1 isoform a	412					carbohydrate metabolic process	extracellular region|membrane	oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor|quinone binding|scavenger receptor activity			skin(2)	2		Melanoma(154;0.128)				GCACTGGCCGCGGGCGCCTCT	0.726		NA											6	4					0	0	0	0
AHNAK2	113146	broad.mit.edu	37	14	105421961	105421961	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr14:105421961C>T	uc010axc.1	-	5	445	c.325G>A	c.(325-327)GAG>AAG	p.E109K	AHNAK2_uc001ypx.2_Missense_Mutation_p.E9K	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	109						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			TCTGTTGCCTCCTGGACAGCC	0.602		NA											30	48					0	0	0	0
ATP8B4	79895	broad.mit.edu	37	15	50264849	50264849	+	Silent	SNP	G	G	T			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr15:50264849G>T	uc001zxu.2	-	13	1315	c.1173C>A	c.(1171-1173)TCC>TCA	p.S391S	ATP8B4_uc010ber.2_Silent_p.S264S|ATP8B4_uc010ufd.1_Silent_p.S264S|ATP8B4_uc010ufe.1_RNA	NM_024837	NP_079113	Q8TF62	AT8B4_HUMAN	ATPase class I type 8B member 4	391	Cytoplasmic (Potential).				ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			skin(3)|ovary(2)|breast(2)|large_intestine(1)	8		all_lung(180;0.00183)		all cancers(107;2.41e-07)|GBM - Glioblastoma multiforme(94;8.28e-05)		CCGTTTTGTCGGAGAAAATGT	0.433		NA											20	3					3.8e-18	5.02e-18	1	0
USP8	9101	broad.mit.edu	37	15	50769168	50769168	+	Silent	SNP	G	G	A			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr15:50769168G>A	uc001zym.3	+	10	1472	c.972G>A	c.(970-972)CAG>CAA	p.Q324Q	USP8_uc001zyk.1_Missense_Mutation_p.R24K|USP8_uc001zyl.3_Silent_p.Q324Q|USP8_uc001zyn.3_Silent_p.Q324Q|USP8_uc010ufh.1_Silent_p.Q247Q|USP8_uc010bev.1_Intron	NM_001128611	NP_001122083	P40818	UBP8_HUMAN	ubiquitin specific peptidase 8	324					cell cycle|cell proliferation|endosome organization|protein K48-linked deubiquitination|protein K63-linked deubiquitination|ubiquitin-dependent protein catabolic process	cytosol|early endosome|extrinsic to plasma membrane|nucleus	cysteine-type endopeptidase activity|SH3 domain binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			lung(1)|central_nervous_system(1)	2				all cancers(107;0.000225)|GBM - Glioblastoma multiforme(94;0.000771)		CACGACGCCAGAATGAAGAGG	0.393		NA											26	14					0	0	0	0
CSPG4	1464	broad.mit.edu	37	15	75982451	75982451	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr15:75982451G>A	uc002baw.2	-	3	1048	c.955C>T	c.(955-957)CGG>TGG	p.R319W		NM_001897	NP_001888	Q6UVK1	CSPG4_HUMAN	chondroitin sulfate proteoglycan 4 precursor	319	Extracellular (Potential).|Neurite growth inhibition (By similarity).|Globular or compact configuration stabilized by disulfide bonds.|Laminin G-like 2.				angiogenesis|cell differentiation|intracellular signal transduction|positive regulation of peptidyl-tyrosine phosphorylation|tissue remodeling	apical plasma membrane|cell surface|integral to plasma membrane|intracellular|lamellipodium membrane	protein kinase binding|signal transducer activity			ovary(2)|pancreas(1)	3						AGACTGCCCCGTGGCTCCAGG	0.617		NA											12	7					0	0	0	0
HDGFRP3	50810	broad.mit.edu	37	15	83820108	83820108	+	Silent	SNP	G	G	A			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr15:83820108G>A	uc002bjs.1	-	5	620	c.465C>T	c.(463-465)TCC>TCT	p.S155S		NM_016073	NP_057157	Q9Y3E1	HDGR3_HUMAN	hepatoma-derived growth factor, related protein	155					cell proliferation	nucleus	growth factor activity				0						ACTGTTTAGAGGATTTCTAAA	0.393		NA											17	31					0	0	0	0
CACNA1H	8912	broad.mit.edu	37	16	1245997	1245997	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr16:1245997C>T	uc002cks.2	+	5	865	c.617C>T	c.(616-618)CCC>CTC	p.P206L	CACNA1H_uc002ckt.2_Missense_Mutation_p.P206L	NM_021098	NP_066921	O95180	CAC1H_HUMAN	calcium channel, voltage-dependent, T type,	206	Helical; Name=S4 of repeat I; (Potential).|I.				aldosterone biosynthetic process|axon guidance|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|muscle contraction|myoblast fusion|positive regulation of acrosome reaction|regulation of heart contraction	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(2)	2		Hepatocellular(780;0.00369)			Flunarizine(DB04841)|Mibefradil(DB01388)	GTGCTGCGGCCCCTCCGCGCC	0.657		NA											41	56					0	0	0	0
RAB26	25837	broad.mit.edu	37	16	2201695	2201695	+	Splice_Site	SNP	G	G	T			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr16:2201695G>T	uc002cou.2	+	4	483	c.349_splice	c.e4-1	p.M117_splice	RAB26_uc010bsf.2_Splice_Site_p.M51_splice	NM_014353	NP_055168	Q9ULW5	RAB26_HUMAN	RAB26, member RAS oncogene family						exocrine system development|protein transport|regulation of exocytosis|small GTPase mediated signal transduction	intrinsic to plasma membrane	GTP binding|protein binding				0						TGTCGCTGCAGATGTGGGACA	0.622		NA											16	31					7.05e-17	9.26e-17	1	0
RAB26	25837	broad.mit.edu	37	16	2203334	2203334	+	Missense_Mutation	SNP	G	G	A	rs149402189	byFrequency	TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr16:2203334G>A	uc002cou.2	+	9	817	c.683G>A	c.(682-684)CGC>CAC	p.R228H	RAB26_uc010bsf.2_Missense_Mutation_p.R162H|TRAF7_uc002cow.2_5'Flank	NM_014353	NP_055168	Q9ULW5	RAB26_HUMAN	RAB26, member RAS oncogene family	228					exocrine system development|protein transport|regulation of exocytosis|small GTPase mediated signal transduction	intrinsic to plasma membrane	GTP binding|protein binding				0						TTGAAGCAGCGCTCCATGAAG	0.642		NA											26	48					0	0	0	0
USP7	7874	broad.mit.edu	37	16	8990890	8990890	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr16:8990890C>G	uc002czl.2	-	26	2984	c.2785G>C	c.(2785-2787)GTG>CTG	p.V929L	USP7_uc010uyk.1_Missense_Mutation_p.V830L|USP7_uc002czj.2_RNA|USP7_uc010uyj.1_Missense_Mutation_p.V830L|USP7_uc002czk.2_Missense_Mutation_p.V913L	NM_003470	NP_003461	Q93009	UBP7_HUMAN	ubiquitin specific peptidase 7	929					interspecies interaction between organisms|multicellular organismal development|protein deubiquitination|regulation of sequence-specific DNA binding transcription factor activity|ubiquitin-dependent protein catabolic process	cytoplasm|PML body	cysteine-type endopeptidase activity|p53 binding|protein C-terminus binding|transcription factor binding|ubiquitin protein ligase binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(3)	3						CCAAGCTCCACGGCCTTTTTA	0.438		NA											13	251					0	0	0	0
CIITA	4261	broad.mit.edu	37	16	11004076	11004076	+	Nonsense_Mutation	SNP	G	G	T			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr16:11004076G>T	uc002dai.3	+	13	2981	c.2848G>T	c.(2848-2850)GAG>TAG	p.E950*	CIITA_uc002daj.3_Nonsense_Mutation_p.E951*|CIITA_uc002dak.3_Nonsense_Mutation_p.E366*|CIITA_uc010bup.1_Silent_p.G346G	NM_000246	NP_000237	P33076	C2TA_HUMAN	class II transactivator	950			Missing (in BLS2).		interferon-gamma-mediated signaling pathway|negative regulation of transcription from RNA polymerase II promoter|positive regulation of MHC class I biosynthetic process|positive regulation of transcription from RNA polymerase II promoter|response to antibiotic|transcription, DNA-dependent	nucleus	activating transcription factor binding|ATP binding|protein C-terminus binding|protein complex binding|transcription coactivator activity|transcription regulatory region DNA binding			central_nervous_system(1)	1						CACAGCTGGGGAGCTCCCTGC	0.557		NA	T	FLJ27352|CD274|CD273|RALGDS|RUNDC2A|C16orf75	PMBL|Hodgkin Lymphona|								11	22					0.00010058	0.000118119	1	0
MYH11	4629	broad.mit.edu	37	16	15797863	15797863	+	Silent	SNP	G	G	A			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr16:15797863G>A	uc002ddy.2	-	41	6011	c.5904C>T	c.(5902-5904)ACC>ACT	p.T1968T	MYH11_uc002ddv.2_3'UTR|MYH11_uc002ddw.2_3'UTR|MYH11_uc002ddx.2_Silent_p.T1975T|MYH11_uc010bvg.2_3'UTR|NDE1_uc010uzy.1_Intron|NDE1_uc002dds.2_Intron	NM_002474	NP_002465	P35749	MYH11_HUMAN	smooth muscle myosin heavy chain 11 isoform	1968	Carboxyl-terminal.				axon guidance|cardiac muscle fiber development|elastic fiber assembly|skeletal muscle myosin thick filament assembly|smooth muscle contraction	cytosol|melanosome|muscle myosin complex|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			ovary(6)|skin(3)|lung(2)|breast(2)|upper_aerodigestive_tract(1)|pancreas(1)	15						CACTGGCCTTGGTTCCATTGA	0.428		NA	T	CBFB	AML								111	153					0	0	0	0
ZNF768	79724	broad.mit.edu	37	16	30536326	30536326	+	Missense_Mutation	SNP	C	C	A			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr16:30536326C>A	uc002dyk.3	-	2	1311	c.1135G>T	c.(1135-1137)GGC>TGC	p.G379C	ZNF768_uc010vex.1_Missense_Mutation_p.G348C|uc002dyl.1_5'Flank|ZNF768_uc010vew.1_Missense_Mutation_p.G348C	NM_024671	NP_078947	Q9H5H4	ZN768_HUMAN	zinc finger protein 768	379	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	DNA-directed RNA polymerase II, core complex	DNA binding|zinc ion binding				0						TAGCACTTGCCGCACTCGGTG	0.637		NA											23	20					2.42e-17	3.18e-17	1	0
ITGAD	3681	broad.mit.edu	37	16	31422110	31422110	+	Missense_Mutation	SNP	G	G	T			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr16:31422110G>T	uc002ebv.1	+	12	1316	c.1267G>T	c.(1267-1269)GCC>TCC	p.A423S	ITGAD_uc010cap.1_Missense_Mutation_p.A423S	NM_005353	NP_005344	Q13349	ITAD_HUMAN	integrin, alpha D precursor	423	FG-GAP 4.|Extracellular (Potential).				cell-cell adhesion|cell-matrix adhesion|immune response|integrin-mediated signaling pathway	integrin complex	receptor activity			skin(1)	1						GGTCCTGGGGGCCCCCCGCTA	0.642		NA											25	53					7.38e-10	9.3e-10	1	0
RFWD3	55159	broad.mit.edu	37	16	74695292	74695292	+	Missense_Mutation	SNP	T	T	A			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr16:74695292T>A	uc002fda.2	-	2	154	c.56A>T	c.(55-57)CAA>CTA	p.Q19L	RFWD3_uc010cgq.2_Missense_Mutation_p.Q19L	NM_018124	NP_060594	Q6PCD5	RFWD3_HUMAN	ring finger and WD repeat domain 3	19					DNA repair|mitotic cell cycle G1/S transition DNA damage checkpoint|response to ionizing radiation	nucleus	MDM2 binding|p53 binding|ubiquitin-protein ligase activity|zinc ion binding			lung(2)|breast(1)	3						AGCTGGCTGTTGTTCGGCATG	0.483		NA											112	170					0	0	0	0
GAN	8139	broad.mit.edu	37	16	81399047	81399047	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr16:81399047C>T	uc002fgo.2	+	9	1614	c.1466C>T	c.(1465-1467)ACT>ATT	p.T489I		NM_022041	NP_071324	Q9H2C0	GAN_HUMAN	gigaxonin	489	Kelch 5.				cell death	cytoplasm|neurofilament	protein binding			ovary(2)	2		Colorectal(91;0.153)				GAGATGGTAACTTGCAAGTCC	0.468		NA											93	96					0	0	0	0
ITGAE	3682	broad.mit.edu	37	17	3631298	3631298	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr17:3631298C>T	uc002fwo.3	-	26	3098	c.2999G>A	c.(2998-3000)GGA>GAA	p.G1000E		NM_002208	NP_002199	P38570	ITAE_HUMAN	integrin, alpha E precursor	1000	Extracellular (Potential).				cell adhesion|integrin-mediated signaling pathway	integrin complex	receptor activity			large_intestine(2)|breast(1)|pancreas(1)	4				UCEC - Uterine corpus endometrioid carcinoma (3;0.0813)		GTATTCTGCTCCAAAGAGGTT	0.418		NA											36	42					0	0	0	0
TP53	7157	broad.mit.edu	37	17	7576928	7576928	+	Splice_Site	SNP	T	T	C			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr17:7576928T>C	uc002gim.2	-	9	1114	c.920_splice	c.e9-1	p.A307_splice	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Splice_Site_p.A307_splice|TP53_uc010cne.1_Splice_Site|TP53_uc010cnf.1_Splice_Site_p.A175_splice|TP53_uc010cng.1_Splice_Site_p.A175_splice|TP53_uc002gii.1_Splice_Site_p.A175_splice|TP53_uc010cnh.1_Splice_Site_p.A307_splice|TP53_uc010cni.1_Splice_Site_p.A307_splice|TP53_uc002gij.2_Splice_Site_p.A307_splice	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a						activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.?(14)|p.0?(7)|p.A307fs*34(1)|p.L308fs*31(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		TGGGCAGTGCTAGGAAAGAGG	0.493		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			46	45					0	0	0	0
NOS2	4843	broad.mit.edu	37	17	26125804	26125804	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr17:26125804G>C	uc002gzu.2	-	2	296	c.32C>G	c.(31-33)ACC>AGC	p.T11S	NOS2_uc010crh.1_Missense_Mutation_p.T11S|NOS2_uc010wab.1_Missense_Mutation_p.T11S	NM_000625	NP_000616	P35228	NOS2_HUMAN	nitric oxide synthase 2A	11					arginine catabolic process|defense response to Gram-negative bacterium|innate immune response in mucosa|nitric oxide biosynthetic process|peptidyl-cysteine S-nitrosylation|platelet activation|positive regulation of killing of cells of other organism|positive regulation of leukocyte mediated cytotoxicity|regulation of cellular respiration|regulation of insulin secretion|superoxide metabolic process	cytosol|nucleus	arginine binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|protein homodimerization activity|tetrahydrobiopterin binding			skin(2)|ovary(1)|breast(1)	4					Dexamethasone(DB01234)|Hydrocortisone(DB00741)|L-Arginine(DB00125)|L-Citrulline(DB00155)	GTGGAATTTGGTCTTGAACAG	0.458		NA											33	33					0	0	0	0
SUPT6H	6830	broad.mit.edu	37	17	27009843	27009843	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr17:27009843C>T	uc002hby.2	+	14	1786	c.1696C>T	c.(1696-1698)CCC>TCC	p.P566S	SUPT6H_uc010crt.2_Missense_Mutation_p.P566S	NM_003170	NP_003161	Q7KZ85	SPT6H_HUMAN	suppressor of Ty 6 homolog	566					chromatin remodeling|regulation of transcription elongation, DNA-dependent|regulation of transcription from RNA polymerase II promoter	nucleus	hydrolase activity, acting on ester bonds|RNA binding|sequence-specific DNA binding transcription factor activity			ovary(2)|skin(1)	3	Lung NSC(42;0.00431)					TCCCGCGGAGCCCTTGGAGCT	0.602		NA											33	46					0	0	0	0
AATF	26574	broad.mit.edu	37	17	35306512	35306512	+	Silent	SNP	G	G	A			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr17:35306512G>A	uc002hni.2	+	1	338	c.87G>A	c.(85-87)GAG>GAA	p.E29E	AATF_uc002hnj.2_RNA	NM_012138	NP_036270	Q9NY61	AATF_HUMAN	apoptosis antagonizing transcription factor	29					anti-apoptosis|apoptosis|induction of apoptosis by extracellular signals|negative regulation of superoxide anion generation|nerve growth factor receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to DNA damage stimulus	centrosome|focal adhesion|nucleolus	leucine zipper domain binding|sequence-specific DNA binding transcription factor activity				0		Breast(25;0.00607)				CGGACCCCGAGGAAGGTGAGG	0.746		NA											3	6					0	0	0	0
KRTAP4-11	653240	broad.mit.edu	37	17	39274113	39274113	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr17:39274113G>A	uc002hvz.2	-	1	494	c.455C>T	c.(454-456)TCC>TTC	p.S152F		NM_033059	NP_149048	Q9BYQ6	KR411_HUMAN	keratin associated protein 4-11	152	27 X 5 AA repeats of C-C-[GIKRQVHEL]- [SPTR]-[STVQRMC].|25.					keratin filament					0		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000371)			gcagcagctggattcacagca	0.239		NA											9	27					0	0	0	0
RNFT1	51136	broad.mit.edu	37	17	58042024	58042024	+	Missense_Mutation	SNP	T	T	C			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr17:58042024T>C	uc002iya.2	-	1	94	c.1A>G	c.(1-3)ATG>GTG	p.M1V	uc002iye.1_5'Flank|RNFT1_uc002iyb.2_RNA|RNFT1_uc002iyc.2_5'UTR|RNFT1_uc010wop.1_Missense_Mutation_p.M1V|RNFT1_uc002iyd.3_Missense_Mutation_p.M1V	NM_016125	NP_057209	Q5M7Z0	RNFT1_HUMAN	PTD016 protein	1						integral to membrane	zinc ion binding				0	all_cancers(5;1.58e-13)|Breast(5;2.91e-25)|all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		Epithelial(12;7.95e-12)|all cancers(12;1.34e-10)			AACAGCGGCATACACCGCCTC	0.701		NA											6	9					0	0	0	0
TLK2	11011	broad.mit.edu	37	17	60685501	60685501	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr17:60685501G>C	uc010ddp.2	+	22	2405	c.2137G>C	c.(2137-2139)GAA>CAA	p.E713Q	TLK2_uc002izx.3_Missense_Mutation_p.E539Q|TLK2_uc002izz.3_Missense_Mutation_p.E691Q|TLK2_uc002jaa.3_Missense_Mutation_p.E659Q|TLK2_uc010wpd.1_Missense_Mutation_p.E659Q	NM_006852	NP_006843	Q86UE8	TLK2_HUMAN	tousled-like kinase 2 isoform A	713	Protein kinase.				cell cycle|chromatin modification|intracellular signal transduction|regulation of chromatin assembly or disassembly|response to DNA damage stimulus	nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			stomach(1)|kidney(1)	2						AGTAACACCTGAAGCAAAGGT	0.433		NA											35	29					0	0	0	0
RECQL5	9400	broad.mit.edu	37	17	73624385	73624385	+	Silent	SNP	G	G	A			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr17:73624385G>A	uc010dgl.2	-	18	2874	c.2718C>T	c.(2716-2718)TCC>TCT	p.S906S	RECQL5_uc010dgk.2_Silent_p.S879S|RECQL5_uc002jot.3_Silent_p.S102S	NM_004259	NP_004250	O94762	RECQ5_HUMAN	RecQ protein-like 5 isoform 1	906					DNA recombination|DNA repair	cytoplasm|nuclear membrane|nucleolus|nucleoplasm	ATP binding|ATP-dependent helicase activity|DNA helicase activity|nucleic acid binding			kidney(3)	3	all_cancers(13;2.73e-08)|Breast(9;6.04e-09)|all_epithelial(9;6.79e-09)		all cancers(21;1.15e-06)|Epithelial(20;2.19e-06)|Lung(188;0.101)|LUSC - Lung squamous cell carcinoma(166;0.112)			CGCCAGGAGCGGAGAGCTGGA	0.597		NA						Other_identified_genes_with_known_or_suspected_DNA_repair_function					8	49					0	0	0	0
RNF213	57674	broad.mit.edu	37	17	78322014	78322014	+	Missense_Mutation	SNP	C	C	A			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr17:78322014C>A	uc002jyh.1	+	4	4321	c.4098C>A	c.(4096-4098)CAC>CAA	p.H1366Q		NM_020914	NP_065965	Q9HCF4	ALO17_HUMAN	ring finger protein 213	Error:Variant_position_missing_in_Q9HCF4_after_alignment										ovary(8)|lung(6)|breast(3)|large_intestine(2)|central_nervous_system(1)|pancreas(1)	21	all_neural(118;0.0538)		BRCA - Breast invasive adenocarcinoma(99;0.0252)|OV - Ovarian serous cystadenocarcinoma(97;0.057)			GACAGAGGCACAACTCCTTTG	0.597		NA											3	44					6.4e-05	7.63e-05	1	0
PTPRM	5797	broad.mit.edu	37	18	8296397	8296397	+	Missense_Mutation	SNP	A	A	C			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr18:8296397A>C	uc002knn.3	+	18	3250	c.2747A>C	c.(2746-2748)GAC>GCC	p.D916A	PTPRM_uc010dkv.2_Missense_Mutation_p.D929A|PTPRM_uc010wzl.1_Missense_Mutation_p.D703A	NM_002845	NP_002836	P28827	PTPRM_HUMAN	protein tyrosine phosphatase, receptor type, M	916	Tyrosine-protein phosphatase 1.|Cytoplasmic (Potential).				homophilic cell adhesion|negative regulation of angiogenesis|negative regulation of endothelial cell migration|negative regulation of endothelial cell proliferation|response to drug|retina layer formation|retinal ganglion cell axon guidance	cell-cell adherens junction|integral to plasma membrane|lamellipodium|perinuclear region of cytoplasm	cadherin binding|transmembrane receptor protein tyrosine phosphatase activity			lung(3)|ovary(2)|central_nervous_system(1)	6		Colorectal(10;0.234)				GCACCATGGGACTCGGCTAAG	0.423		NA											3	38					0	0	0	0
ZNF846	162993	broad.mit.edu	37	19	9868519	9868519	+	Missense_Mutation	SNP	G	G	T			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr19:9868519G>T	uc002mmb.1	-	6	1765	c.1234C>A	c.(1234-1236)CAT>AAT	p.H412N	ZNF846_uc010xky.1_Intron|ZNF846_uc010xkz.1_Intron|ZNF846_uc010dww.2_Intron|ZNF846_uc002mmc.1_Missense_Mutation_p.H283N	NM_001077624	NP_001071092	Q147U1	ZN846_HUMAN	zinc finger protein 846	412	C2H2-type 10.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						ATCCTTACATGTTGACTAAGC	0.403		NA											28	52					4.23e-11	5.38e-11	1	0
KRI1	65095	broad.mit.edu	37	19	10675688	10675688	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr19:10675688C>T	uc002moy.1	-	3	218	c.209G>A	c.(208-210)CGG>CAG	p.R70Q	KRI1_uc002mox.1_Missense_Mutation_p.R66Q	NM_023008	NP_075384	Q8N9T8	KRI1_HUMAN	KRI1 homolog	70										ovary(1)	1			Epithelial(33;9.2e-06)|all cancers(31;3.9e-05)			GTAAAAGTCCCGCTCCTGCTG	0.522		NA									OREG0025239	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	34	65					0	0	0	0
CCDC151	115948	broad.mit.edu	37	19	11537725	11537725	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr19:11537725C>G	uc002mrs.2	-	4	723	c.580G>C	c.(580-582)GAG>CAG	p.E194Q	CCDC151_uc002mrr.2_Missense_Mutation_p.E129Q|CCDC151_uc010dxz.2_Missense_Mutation_p.E168Q	NM_145045	NP_659482	A5D8V7	CC151_HUMAN	coiled-coil domain containing 151	194	Potential.									ovary(1)	1						TTTTGCGCCTCCGCCATCTCC	0.677		NA											30	45					0	0	0	0
OR7C2	26658	broad.mit.edu	37	19	15052714	15052714	+	Silent	SNP	C	C	A			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr19:15052714C>A	uc010xoc.1	+	1	414	c.414C>A	c.(412-414)CCC>CCA	p.P138P		NM_012377	NP_036509	O60412	OR7C2_HUMAN	olfactory receptor, family 7, subfamily C,	138	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3	Ovarian(108;0.203)					TCATGAACCCCCGGCTCTGTG	0.537		NA											64	115					2.9e-36	3.88e-36	1	0
NOTCH3	4854	broad.mit.edu	37	19	15288423	15288423	+	Missense_Mutation	SNP	T	T	C			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr19:15288423T>C	uc002nan.2	-	24	4392	c.4316A>G	c.(4315-4317)AAC>AGC	p.N1439S	NOTCH3_uc002nao.1_Missense_Mutation_p.N1387S	NM_000435	NP_000426	Q9UM47	NOTC3_HUMAN	Notch homolog 3 precursor	1439	Extracellular (Potential).|LNR 2.				Notch receptor processing|Notch signaling pathway|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			lung(8)|ovary(5)|skin(4)|prostate(2)|central_nervous_system(1)|breast(1)	21			OV - Ovarian serous cystadenocarcinoma(3;2.6e-20)|Epithelial(3;1.34e-16)|all cancers(3;5.13e-15)			GCAGCGGCTGTTGTTGAAGAG	0.701		NA											7	2					0	0	0	0
AKAP8L	26993	broad.mit.edu	37	19	15514345	15514345	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr19:15514345C>T	uc002naw.1	-	4	402	c.303G>A	c.(301-303)ATG>ATA	p.M101I	AKAP8L_uc002nax.1_RNA|AKAP8L_uc010xoh.1_Intron|AKAP8L_uc002nay.1_Missense_Mutation_p.M101I|AKAP8L_uc002naz.2_5'Flank	NM_014371	NP_055186	Q9ULX6	AKP8L_HUMAN	A kinase (PRKA) anchor protein 8-like	101						cytoplasm|nuclear matrix	DEAD/H-box RNA helicase binding|DNA binding|zinc ion binding			ovary(1)	1						AATGCGGCACCATATCTAAGC	0.537		NA											65	101					0	0	0	0
OR10H5	284433	broad.mit.edu	37	19	15905429	15905429	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr19:15905429G>A	uc010xos.1	+	1	571	c.571G>A	c.(571-573)GAT>AAT	p.D191N		NM_001004466	NP_001004466	Q8NGA6	O10H5_HUMAN	olfactory receptor, family 10, subfamily H,	191	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						GGCCTGTGGAGATGATGTGCT	0.572		NA											6	86					0	0	0	0
SLC5A5	6528	broad.mit.edu	37	19	17988641	17988641	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr19:17988641G>A	uc002nhr.3	+	6	1155	c.808G>A	c.(808-810)GTG>ATG	p.V270M		NM_000453	NP_000444	Q92911	SC5A5_HUMAN	solute carrier family 5 (sodium iodide	270	Cytoplasmic (Potential).				cellular nitrogen compound metabolic process|cellular response to cAMP|cellular response to gonadotropin stimulus|hormone biosynthetic process	integral to membrane|nucleus|plasma membrane	iodide transmembrane transporter activity|sodium:iodide symporter activity			skin(2)|ovary(1)|central_nervous_system(1)	4						GCAGCGCTACGTGGCTTGCCG	0.607		NA											45	67					0	0	0	0
KIAA1683	80726	broad.mit.edu	37	19	18368445	18368445	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr19:18368445C>T	uc002nin.2	-	4	3304	c.3088G>A	c.(3088-3090)GAC>AAC	p.D1030N	PDE4C_uc002nil.3_5'Flank|KIAA1683_uc010ebn.2_Missense_Mutation_p.D1217N|KIAA1683_uc010xqe.1_Missense_Mutation_p.D984N|KIAA1683_uc010xqf.1_RNA	NM_025249	NP_079525	Q9H0B3	K1683_HUMAN	KIAA1683 isoform b	1030						mitochondrion				ovary(2)	2						CAGCGATGGTCAGATACTGTC	0.657		NA											25	44					0	0	0	0
ZNF737	100129842	broad.mit.edu	37	19	20736633	20736633	+	Silent	SNP	C	C	T			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr19:20736633C>T	uc002npa.2	-	2	192	c.12G>A	c.(10-12)TTG>TTA	p.L4L		NM_001159293	NP_001152765	C9JHM3	C9JHM3_HUMAN	zinc finger protein 737	4					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding			ovary(1)	1						CTCTAAATTGCAATGGCCCCT	0.403		NA											36	44					0	0	0	0
ZNF507	22847	broad.mit.edu	37	19	32844322	32844322	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr19:32844322C>T	uc002nte.2	+	3	858	c.586C>T	c.(586-588)CCC>TCC	p.P196S	ZNF507_uc002ntc.2_Missense_Mutation_p.P196S|ZNF507_uc010xrn.1_Missense_Mutation_p.P196S|ZNF507_uc002ntd.2_Missense_Mutation_p.P196S	NM_001136156	NP_001129628	Q8TCN5	ZN507_HUMAN	zinc finger protein 507	196					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|pancreas(1)|kidney(1)|central_nervous_system(1)|skin(1)	5	Esophageal squamous(110;0.162)					GTGCGTAAGCCCCTCCAGCTC	0.468		NA											37	49					0	0	0	0
MLL4	9757	broad.mit.edu	37	19	36210733	36210733	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr19:36210733C>T	uc010eei.2	+	3	484	c.484C>T	c.(484-486)CCT>TCT	p.P162S		NM_014727	NP_055542	Q9UMN6	MLL4_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 4	162					chromatin-mediated maintenance of transcription		DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(6)|breast(2)|ovary(1)|kidney(1)|skin(1)	11	all_lung(56;3.33e-07)|Lung NSC(56;5.02e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			GACCCCCCTTCCTCCTCCTCG	0.607		NA											52	97					0	0	0	0
HNRNPL	3191	broad.mit.edu	37	19	39336596	39336596	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr19:39336596G>C	uc010xul.1	-	3	532	c.521C>G	c.(520-522)TCT>TGT	p.S174C	HNRNPL_uc010xum.1_Missense_Mutation_p.S41C|HNRNPL_uc010xun.1_5'Flank	NM_001533	NP_001524	P14866	HNRPL_HUMAN	heterogeneous nuclear ribonucleoprotein L	174	RRM 1.				nuclear mRNA splicing, via spliceosome	cytoplasm|heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	nucleotide binding|protein binding|RNA binding|transcription regulatory region DNA binding				0	all_cancers(60;6.83e-06)|Ovarian(47;0.0454)		Lung(45;0.00342)|LUSC - Lung squamous cell carcinoma(53;0.00575)			CTGGCTGGTAGAGTAGTTGAC	0.522		NA											51	98					0	0	0	0
CLPTM1	1209	broad.mit.edu	37	19	45496120	45496120	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr19:45496120C>T	uc002pai.2	+	14	1990	c.1975C>T	c.(1975-1977)CCT>TCT	p.P659S	CLPTM1_uc010xxf.1_Missense_Mutation_p.P557S|CLPTM1_uc010xxg.1_Missense_Mutation_p.P645S	NM_001294	NP_001285	O96005	CLPT1_HUMAN	cleft lip and palate associated transmembrane	659	Cytoplasmic (Potential).				cell differentiation|multicellular organismal development|regulation of T cell differentiation in thymus	external side of plasma membrane|integral to plasma membrane				ovary(1)	1		all_neural(266;0.224)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.00354)|Epithelial(262;0.187)		CCAGGAAGCCCCTCCAAAGCC	0.682		NA											20	33					0	0	0	0
CKM	1158	broad.mit.edu	37	19	45810135	45810135	+	Missense_Mutation	SNP	T	T	C			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr19:45810135T>C	uc002pbd.2	-	8	1093	c.1019A>G	c.(1018-1020)GAT>GGT	p.D340G		NM_001824	NP_001815	P06732	KCRM_HUMAN	muscle creatine kinase	340	Phosphagen kinase C-terminal.				creatine metabolic process	cytosol	ATP binding|creatine kinase activity			skin(1)	1		Ovarian(192;0.0336)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;2.29e-44)|Epithelial(262;1.05e-38)|GBM - Glioblastoma multiforme(486;3.56e-07)	Creatine(DB00148)	GCCCAGCCGATCAGCGTTGGA	0.582		NA											57	116					0	0	0	0
VASP	7408	broad.mit.edu	37	19	46027399	46027399	+	Missense_Mutation	SNP	A	A	T			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr19:46027399A>T	uc002pcg.2	+	10	1297	c.955A>T	c.(955-957)AGG>TGG	p.R319W	VASP_uc010eki.2_Missense_Mutation_p.R153W|VASP_uc002pci.2_Missense_Mutation_p.R305W	NM_003370	NP_003361	P50552	VASP_HUMAN	vasodilator-stimulated phosphoprotein	319	EVH2.				axon guidance|cell junction assembly|T cell receptor signaling pathway	actin cytoskeleton|cytosol|filopodium membrane|focal adhesion|lamellipodium membrane	actin binding|profilin binding|SH3 domain binding				0		Ovarian(192;0.051)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.0145)|GBM - Glioblastoma multiforme(486;0.154)		AACCTTGCCAAGGTAGGCCAT	0.323		NA									OREG0025556	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	31	29					0	0	0	0
MYH14	79784	broad.mit.edu	37	19	50713685	50713685	+	Silent	SNP	C	C	T			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr19:50713685C>T	uc002prr.1	+	2	110	c.63C>T	c.(61-63)CCC>CCT	p.P21P	MYH14_uc010enu.1_Silent_p.P21P|MYH14_uc002prq.1_Silent_p.P21P	NM_024729	NP_079005	Q7Z406	MYH14_HUMAN	myosin, heavy chain 14 isoform 2	21	Myosin head-like.				axon guidance|regulation of cell shape	myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			central_nervous_system(1)	1		all_neural(266;0.0571)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.00389)|GBM - Glioblastoma multiforme(134;0.0195)		GCCCAGTGCCCGAGGCGGCCC	0.756		NA											5	1					0	0	0	0
ZNF845	91664	broad.mit.edu	37	19	53854940	53854940	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr19:53854940C>G	uc010ydv.1	+	4	1129	c.1012C>G	c.(1012-1014)CAA>GAA	p.Q338E	ZNF845_uc010ydw.1_Missense_Mutation_p.Q338E	NM_138374	NP_612383	Q96IR2	ZN845_HUMAN	zinc finger protein 845	338	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						GACCTTCAGTCAAACGTCATA	0.388		NA											29	50					0	0	0	0
PRKCG	5582	broad.mit.edu	37	19	54401792	54401792	+	Silent	SNP	G	G	C			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr19:54401792G>C	uc002qcq.1	+	11	1473	c.1191G>C	c.(1189-1191)CTG>CTC	p.L397L	PRKCG_uc010yef.1_3'UTR|PRKCG_uc010yeg.1_Silent_p.L397L|PRKCG_uc010yeh.1_Silent_p.L284L	NM_002739	NP_002730	P05129	KPCG_HUMAN	protein kinase C, gamma	397	Protein kinase.				activation of phospholipase C activity|cell death|intracellular signal transduction|negative regulation of protein catabolic process|negative regulation of protein ubiquitination|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of mismatch repair|synaptic transmission	cytosol	ATP binding|protein kinase C activity|zinc ion binding			lung(4)|ovary(2)|pancreas(2)|large_intestine(1)	9	all_cancers(19;0.0462)|all_epithelial(19;0.0258)|all_lung(19;0.185)|Ovarian(34;0.19)|Lung NSC(19;0.218)			GBM - Glioblastoma multiforme(134;0.0521)		ACTGCACGCTGGTGGAGAAAC	0.637		NA											13	19					0	0	0	0
KIF3C	3797	broad.mit.edu	37	2	26203809	26203809	+	Silent	SNP	G	G	C			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr2:26203809G>C	uc002rgu.2	-	1	1635	c.978C>G	c.(976-978)CTC>CTG	p.L326L	KIF3C_uc010eyj.1_RNA|KIF3C_uc010ykr.1_Silent_p.L326L	NM_002254	NP_002245	O14782	KIF3C_HUMAN	kinesin family member 3C	326	Kinesin-motor.				blood coagulation|microtubule-based movement	cytosol|kinesin complex|microtubule	ATP binding|microtubule motor activity			ovary(3)|skin(1)	4	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GGGAGTCCTGGAGCAGCCGGG	0.607		NA											22	46					0	0	0	0
PRKD3	23683	broad.mit.edu	37	2	37506980	37506980	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr2:37506980C>T	uc002rqd.2	-	7	1636	c.1081G>A	c.(1081-1083)GAA>AAA	p.E361K	PRKD3_uc002rqe.1_5'Flank|PRKD3_uc002rqf.1_Missense_Mutation_p.E361K	NM_005813	NP_005804	O94806	KPCD3_HUMAN	protein kinase D3	361					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction	cytoplasm|membrane|nucleus	ATP binding|metal ion binding|protein binding|protein kinase C activity			lung(2)|ovary(1)|central_nervous_system(1)	4		all_hematologic(82;0.21)				GATGGCTCTTCTGTGTCATCC	0.398		NA											50	49					0	0	0	0
ABCG8	64241	broad.mit.edu	37	2	44099198	44099198	+	Silent	SNP	C	C	T			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr2:44099198C>T	uc002rtq.2	+	7	1138	c.1048C>T	c.(1048-1050)CTA>TTA	p.L350L	ABCG8_uc010yoa.1_Silent_p.L350L	NM_022437	NP_071882	Q9H221	ABCG8_HUMAN	ATP-binding cassette sub-family G member 8	350	Cytoplasmic (Potential).				cholesterol efflux|cholesterol homeostasis|excretion|lipid metabolic process|negative regulation of intestinal cholesterol absorption|negative regulation of intestinal phytosterol absorption	apical plasma membrane|integral to membrane	ATP binding|ATPase activity|protein heterodimerization activity			skin(3)|ovary(1)	4		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)				AGCCCTGTTTCTAGAAAAAGT	0.537		NA											48	72					0	0	0	0
LRPPRC	10128	broad.mit.edu	37	2	44162018	44162018	+	Splice_Site	SNP	C	C	A			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr2:44162018C>A	uc002rtr.2	-	24	2563	c.2505_splice	c.e24-1	p.K835_splice	LRPPRC_uc010yob.1_Splice_Site_p.K735_splice	NM_133259	NP_573566	P42704	LPPRC_HUMAN	leucine-rich PPR motif-containing protein						mitochondrion transport along microtubule|mRNA transport|regulation of transcription, DNA-dependent|transcription, DNA-dependent	condensed nuclear chromosome|cytoskeleton|mitochondrial nucleoid|nuclear inner membrane|nuclear outer membrane|nucleoplasm|perinuclear region of cytoplasm	beta-tubulin binding|microtubule binding|RNA binding			ovary(2)|skin(1)	3		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)				TAGGTCGCCCCTTAGAAACAA	0.328		NA											23	38					2.22e-12	2.82e-12	1	0
EFEMP1	2202	broad.mit.edu	37	2	56149558	56149558	+	Silent	SNP	G	G	A			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr2:56149558G>A	uc002rzh.2	-	2	348	c.18C>T	c.(16-18)TTC>TTT	p.F6F	EFEMP1_uc002rzi.2_Silent_p.F6F|EFEMP1_uc002rzj.2_Silent_p.F6F|EFEMP1_uc010ypc.1_5'UTR	NM_004105	NP_004096	Q12805	FBLN3_HUMAN	EGF-containing fibulin-like extracellular matrix	6					negative regulation of chondrocyte differentiation|peptidyl-tyrosine phosphorylation|regulation of transcription, DNA-dependent|visual perception	extracellular space|proteinaceous extracellular matrix	calcium ion binding|epidermal growth factor receptor activity|epidermal growth factor receptor binding|growth factor activity			ovary(4)|pancreas(1)|skin(1)	6			LUSC - Lung squamous cell carcinoma(58;0.127)|Lung(47;0.132)			GCATAGTTAGGAAAAGGGCTT	0.428		NA											66	71					0	0	0	0
SLC5A7	60482	broad.mit.edu	37	2	108626706	108626706	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr2:108626706G>A	uc002tdv.2	+	9	1408	c.1132G>A	c.(1132-1134)GTT>ATT	p.V378I	SLC5A7_uc010ywm.1_Missense_Mutation_p.V131I|SLC5A7_uc010fjj.2_Missense_Mutation_p.V378I|SLC5A7_uc010ywn.1_Missense_Mutation_p.V265I	NM_021815	NP_068587	Q9GZV3	SC5A7_HUMAN	solute carrier family 5 (choline transporter),	378	Helical; (Potential).				acetylcholine biosynthetic process|neurotransmitter secretion	integral to membrane|plasma membrane	choline:sodium symporter activity	p.V378I(1)		ovary(2)|central_nervous_system(1)|skin(1)	4					Choline(DB00122)	CAAAGAAATCGTTTGGGTTAT	0.443		NA											42	60					0	0	0	0
LY75	4065	broad.mit.edu	37	2	160663608	160663608	+	Silent	SNP	G	G	C			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr2:160663608G>C	uc002ubc.3	-	34	4935	c.4866C>G	c.(4864-4866)GTC>GTG	p.V1622V	LY75_uc002ubb.3_Silent_p.V1622V|LY75_uc010fos.2_Intron	NM_002349	NP_002340	O60449	LY75_HUMAN	lymphocyte antigen 75 precursor	1622	Extracellular (Potential).|C-type lectin 10.				endocytosis|immune response|inflammatory response	integral to plasma membrane	receptor activity|sugar binding				0				COAD - Colon adenocarcinoma(177;0.132)		TTTCCCATTTGACAAATGTCA	0.343		NA											15	40					0	0	0	0
ITGB6	3694	broad.mit.edu	37	2	160994637	160994637	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr2:160994637C>T	uc002ubh.2	-	9	1197	c.1181G>A	c.(1180-1182)TGT>TAT	p.C394Y	ITGB6_uc010fou.2_Missense_Mutation_p.C394Y|ITGB6_uc010zcq.1_Missense_Mutation_p.C352Y|ITGB6_uc010fov.1_Missense_Mutation_p.C394Y	NM_000888	NP_000879	P18564	ITB6_HUMAN	integrin, beta 6 precursor	394	Extracellular (Potential).				cell-matrix adhesion|integrin-mediated signaling pathway|interspecies interaction between organisms|multicellular organismal development	integrin complex	receptor activity			ovary(1)|lung(1)|skin(1)	3						ACCGTTGTTACAGATGGCTGT	0.428		NA											6	134					0	0	0	0
KLHL23	151230	broad.mit.edu	37	2	170591601	170591601	+	Missense_Mutation	SNP	T	T	C			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr2:170591601T>C	uc002ufh.1	+	4	415	c.77T>C	c.(76-78)TTC>TCC	p.F26S	KLHL23_uc002ufi.1_Missense_Mutation_p.F26S	NM_144711	NP_653312	Q8NBE8	KLH23_HUMAN	kelch-like 23	26											0						CTGGATGCATTCAGAACATTT	0.363		NA											5	118					0	0	0	0
ITGA4	3676	broad.mit.edu	37	2	182387035	182387035	+	Silent	SNP	C	C	T			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr2:182387035C>T	uc002unu.2	+	18	2803	c.2040C>T	c.(2038-2040)CCC>CCT	p.P680P	ITGA4_uc010frj.1_Silent_p.P162P|ITGA4_uc002unv.2_5'UTR	NM_000885	NP_000876	P13612	ITA4_HUMAN	integrin alpha 4 precursor	680	Extracellular (Potential).				blood coagulation|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|regulation of immune response	integrin complex	identical protein binding|receptor activity			ovary(3)|lung(1)|central_nervous_system(1)|pancreas(1)	6			OV - Ovarian serous cystadenocarcinoma(117;0.0593)		Natalizumab(DB00108)	TCAAACTACCCGTGGGTCTTT	0.338		NA											25	47					0	0	0	0
ZNF804A	91752	broad.mit.edu	37	2	185801843	185801843	+	Missense_Mutation	SNP	G	G	T			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr2:185801843G>T	uc002uph.2	+	4	2314	c.1720G>T	c.(1720-1722)GAT>TAT	p.D574Y		NM_194250	NP_919226	Q7Z570	Z804A_HUMAN	zinc finger protein 804A	574						intracellular	zinc ion binding			ovary(6)|skin(3)|large_intestine(1)|pancreas(1)	11						GGACACTCTAGATGAAAAATA	0.299		NA											20	42					3.62e-10	4.58e-10	1	0
RAB17	64284	broad.mit.edu	37	2	238483689	238483689	+	Silent	SNP	C	C	T			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr2:238483689C>T	uc002vwz.1	-	6	1256	c.612G>A	c.(610-612)GCG>GCA	p.A204A	RAB17_uc002vxa.1_RNA|RAB17_uc002vxb.1_RNA	NM_022449	NP_071894	Q9H0T7	RAB17_HUMAN	RAB17, member RAS oncogene family	204					protein transport|small GTPase mediated signal transduction	intracellular|plasma membrane	GTP binding|protein binding				0		Renal(207;0.00272)|Breast(86;0.00297)|all_hematologic(139;0.182)|Ovarian(221;0.221)		Epithelial(121;9.36e-23)|OV - Ovarian serous cystadenocarcinoma(60;1.26e-10)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;0.000354)|Lung(119;0.011)|LUSC - Lung squamous cell carcinoma(224;0.026)		TGGCCTGCCTCGCGGGCCCCT	0.642		NA											30	39					0	0	0	0
FARP2	9855	broad.mit.edu	37	2	242380775	242380775	+	Silent	SNP	C	C	G			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr2:242380775C>G	uc002wbi.1	+	13	1332	c.1215C>G	c.(1213-1215)GCC>GCG	p.A405A	FARP2_uc010zoq.1_Silent_p.A405A|FARP2_uc010zor.1_Silent_p.A405A|uc002wbj.2_5'Flank	NM_014808	NP_055623	O94887	FARP2_HUMAN	FERM, RhoGEF and pleckstrin domain protein 2	405					axon guidance|neuron remodeling|Rac protein signal transduction|regulation of Rho protein signal transduction	cytoskeleton|cytosol|extrinsic to membrane	cytoskeletal protein binding|Rho guanyl-nucleotide exchange factor activity			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3		all_cancers(19;4.88e-34)|all_epithelial(40;4.81e-14)|Breast(86;0.000141)|Renal(207;0.0143)|all_lung(227;0.0344)|Lung NSC(271;0.0886)|Ovarian(221;0.0905)|Esophageal squamous(248;0.131)|all_hematologic(139;0.182)|Melanoma(123;0.238)		Epithelial(32;1.81e-33)|all cancers(36;1.61e-30)|OV - Ovarian serous cystadenocarcinoma(60;6.83e-15)|Kidney(56;1.19e-08)|KIRC - Kidney renal clear cell carcinoma(57;8.98e-08)|BRCA - Breast invasive adenocarcinoma(100;1.49e-06)|Lung(119;0.000152)|LUSC - Lung squamous cell carcinoma(224;0.00125)|Colorectal(34;0.0199)|COAD - Colon adenocarcinoma(134;0.121)		CAGCGAATGCCTTTTACTCGC	0.502		NA											27	56					0	0	0	0
C20orf27	54976	broad.mit.edu	37	20	3739186	3739186	+	Silent	SNP	G	G	C			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr20:3739186G>C	uc002wji.1	-	3	388	c.159C>G	c.(157-159)GTC>GTG	p.V53V	C20orf27_uc002wjf.1_Silent_p.V78V|C20orf27_uc002wjh.1_Silent_p.V78V	NM_001039140	NP_001034229	Q9GZN8	CT027_HUMAN	hypothetical protein LOC54976	53											0						CATGTACCTTGACCAGAAAGC	0.587		NA											7	142					0	0	0	0
RIN2	54453	broad.mit.edu	37	20	19937366	19937366	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr20:19937366G>A	uc002wro.1	+	3	302	c.266G>A	c.(265-267)CGG>CAG	p.R89Q	RIN2_uc010gcu.1_Missense_Mutation_p.R89Q|RIN2_uc010gcv.1_5'UTR	NM_018993	NP_061866	Q8WYP3	RIN2_HUMAN	Ras and Rab interactor 2	89					endocytosis|small GTPase mediated signal transduction	cytoplasm	GTPase activator activity|Rab guanyl-nucleotide exchange factor activity			lung(4)|ovary(1)	5						ATCTTGGACCGGCTCCTCCAC	0.607		NA											4	29					0	0	0	0
ENTPD6	955	broad.mit.edu	37	20	25197285	25197285	+	Silent	SNP	C	C	A			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr20:25197285C>A	uc002wuj.2	+	8	891	c.711C>A	c.(709-711)GGC>GGA	p.G237G	ENTPD6_uc010zsy.1_Silent_p.G237G|ENTPD6_uc010gdj.1_Silent_p.G209G|ENTPD6_uc010zsz.1_Silent_p.G19G|ENTPD6_uc002wum.2_Silent_p.G220G|ENTPD6_uc010zta.1_Silent_p.G237G|ENTPD6_uc002wun.2_Silent_p.G237G|ENTPD6_uc002wuk.2_Silent_p.G236G|ENTPD6_uc002wul.2_Silent_p.G236G|ENTPD6_uc010ztb.1_Silent_p.G209G|ENTPD6_uc010ztc.1_Silent_p.G209G|ENTPD6_uc002wuo.2_Intron|ENTPD6_uc010ztd.1_Silent_p.G19G	NM_001247	NP_001238	O75354	ENTP6_HUMAN	ectonucleoside triphosphate diphosphohydrolase 6	237	Lumenal (Potential).					Golgi membrane|integral to membrane	nucleoside-diphosphatase activity				0						GTGCTCCAGGCAGCTTGAAAA	0.572		NA											9	17					4.69e-08	5.81e-08	1	0
DEFB116	245930	broad.mit.edu	37	20	29891043	29891043	+	Missense_Mutation	SNP	G	G	T			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr20:29891043G>T	uc010ztm.1	-	2	281	c.281C>A	c.(280-282)ACA>AAA	p.T94K		NM_001037731	NP_001032820	Q30KQ4	DB116_HUMAN	beta-defensin 116 precursor	94					defense response to bacterium	extracellular region					0	all_hematologic(12;0.158)		Colorectal(19;0.00254)|COAD - Colon adenocarcinoma(19;0.0347)			TGAACTGTTTGTAACTGACAA	0.383		NA											83	183					3.76e-38	5.08e-38	1	0
SUN5	140732	broad.mit.edu	37	20	31587898	31587898	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr20:31587898G>C	uc002wyi.2	-	5	415	c.322C>G	c.(322-324)CTG>GTG	p.L108V		NM_080675	NP_542406	Q8TC36	SUN5_HUMAN	sperm associated antigen 4-like	108					spermatogenesis					skin(1)	1						CAGAGGAGCAGAATGCCTGTC	0.483		NA											13	71					0	0	0	0
PHF20	51230	broad.mit.edu	37	20	34505531	34505531	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr20:34505531G>A	uc002xek.1	+	13	2062	c.1951G>A	c.(1951-1953)GAG>AAG	p.E651K		NM_016436	NP_057520	Q9BVI0	PHF20_HUMAN	PHD finger protein 20	651					regulation of transcription, DNA-dependent|transcription, DNA-dependent	MLL1 complex	DNA binding|zinc ion binding			ovary(1)	1	Breast(12;0.00631)|all_lung(11;0.0145)					CTATGACTTCGAGGTGGTCCG	0.502		NA											21	52					0	0	0	0
SFRS6	6431	broad.mit.edu	37	20	42087030	42087030	+	Missense_Mutation	SNP	G	G	T			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr20:42087030G>T	uc010zwg.1	+	2	307	c.137G>T	c.(136-138)CGC>CTC	p.R46L	SFRS6_uc002xki.2_5'UTR|SFRS6_uc002xkk.2_Missense_Mutation_p.R46L	NM_006275	NP_006266	Q13247	SRSF6_HUMAN	arginine/serine-rich splicing factor 6	46	RRM 1.				mRNA 3'-end processing|mRNA export from nucleus|mRNA splice site selection|termination of RNA polymerase II transcription	nucleoplasm	nucleotide binding|protein binding|RNA binding				0		Myeloproliferative disorder(115;0.00452)	COAD - Colon adenocarcinoma(18;0.0031)			GAGGACTCCCGCGACGCCGAC	0.721		NA											4	0					0.00024832	0.00028956	1	0
ZNF831	128611	broad.mit.edu	37	20	57769026	57769026	+	Silent	SNP	G	G	T			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr20:57769026G>T	uc002yan.2	+	1	2952	c.2952G>T	c.(2950-2952)CTG>CTT	p.L984L		NM_178457	NP_848552	Q5JPB2	ZN831_HUMAN	zinc finger protein 831	984						intracellular	nucleic acid binding|zinc ion binding			skin(13)|ovary(1)	14	all_lung(29;0.0085)					GGTCAGGACTGGGGACCCCTC	0.632		NA											34	15					3.11e-16	4.07e-16	1	0
MORC3	23515	broad.mit.edu	37	21	37741537	37741537	+	Nonsense_Mutation	SNP	C	C	G			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr21:37741537C>G	uc002yvi.2	+	15	1947	c.1871C>G	c.(1870-1872)TCA>TGA	p.S624*		NM_015358	NP_056173	Q14149	MORC3_HUMAN	MORC family CW-type zinc finger 3	624					cell aging|maintenance of protein location in nucleus|negative regulation of fibroblast proliferation|peptidyl-serine phosphorylation|protein stabilization	aggresome|intermediate filament cytoskeleton|PML body	ATP binding|zinc ion binding			ovary(2)	2						CAGACTGGTTCAACAAGCACC	0.448		NA											33	78					0	0	0	0
SLC37A1	54020	broad.mit.edu	37	21	43962541	43962541	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr21:43962541G>A	uc002zbi.2	+	8	926	c.514G>A	c.(514-516)GGC>AGC	p.G172S	SLC37A1_uc002zbj.2_Missense_Mutation_p.G172S	NM_018964	NP_061837	P57057	GLPT_HUMAN	solute carrier family 37 member 1	172	Helical; (Potential).				carbohydrate transport|transmembrane transport	integral to membrane					0						GCAGACCACCGGCTGGCCCAG	0.577		NA											18	28					0	0	0	0
POTEH	23784	broad.mit.edu	37	22	16279295	16279295	+	Missense_Mutation	SNP	G	G	T			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr22:16279295G>T	uc010gqp.2	-	4	980	c.928C>A	c.(928-930)CTC>ATC	p.L310I	POTEH_uc002zlg.1_RNA|POTEH_uc002zlh.1_Missense_Mutation_p.L29I|POTEH_uc002zlj.1_Missense_Mutation_p.L145I	NM_001136213	NP_001129685	Q6S545	POTEH_HUMAN	ANKRD26-like family C, member 3	310	ANK 5.									skin(1)	1						AGTGGTGTGAGGCCATGCTGT	0.323		NA											36	510					2.22e-12	2.82e-12	1	0
ZNF280A	129025	broad.mit.edu	37	22	22868743	22868743	+	Silent	SNP	C	C	T			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr22:22868743C>T	uc002zwe.2	-	2	1465	c.1212G>A	c.(1210-1212)TCG>TCA	p.S404S	LOC96610_uc011aim.1_Intron	NM_080740	NP_542778	P59817	Z280A_HUMAN	zinc finger protein 280A	404					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1	all_hematologic(9;0.0135)|Acute lymphoblastic leukemia(84;0.17)	all_hematologic(6;1.74e-30)|Acute lymphoblastic leukemia(6;7.75e-22)		READ - Rectum adenocarcinoma(21;0.145)		CAGCAAAGACCGACGATCTGT	0.413		NA											6	116					0	0	0	0
TCF20	6942	broad.mit.edu	37	22	42606032	42606032	+	Silent	SNP	G	G	A			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr22:42606032G>A	uc003bcj.1	-	1	5414	c.5280C>T	c.(5278-5280)TCC>TCT	p.S1760S	TCF20_uc003bck.1_Silent_p.S1760S|TCF20_uc003bnt.2_Silent_p.S1760S	NM_005650	NP_005641	Q9UGU0	TCF20_HUMAN	transcription factor 20 isoform 1	1760					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|transcription coactivator activity|zinc ion binding			ovary(4)|skin(1)	5						TGTCCGTCTTGGAGCCATTAG	0.557		NA											42	88					0	0	0	0
EDEM1	9695	broad.mit.edu	37	3	5246816	5246816	+	Silent	SNP	G	G	A			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr3:5246816G>A	uc003bqi.2	+	6	1239	c.1107G>A	c.(1105-1107)CTG>CTA	p.L369L	EDEM1_uc011asz.1_Silent_p.L147L|EDEM1_uc003bqh.2_Silent_p.L369L	NM_014674	NP_055489	Q92611	EDEM1_HUMAN	ER degradation enhancer, mannosidase alpha-like	369	Lumenal (Potential).				ER-associated protein catabolic process|post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine|response to unfolded protein	integral to endoplasmic reticulum membrane	calcium ion binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity|misfolded protein binding			ovary(2)|breast(1)	3				Epithelial(13;0.0588)|OV - Ovarian serous cystadenocarcinoma(96;0.0682)		GTGCCGGGCTGGACTCCTTCT	0.453		NA											62	29					0	0	0	0
GRIP2	80852	broad.mit.edu	37	3	14565164	14565164	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr3:14565164C>T	uc011avi.1	-	6	736	c.736G>A	c.(736-738)GTC>ATC	p.V246I	GRIP2_uc011avh.1_5'UTR|GRIP2_uc003byu.1_3'UTR|GRIP2_uc003byv.1_Missense_Mutation_p.V149I	NM_001080423	NP_001073892	Q9C0E4	GRIP2_HUMAN	glutamate receptor interacting protein 2	149	PDZ 2.				synaptic transmission	cytosol|plasma membrane	protein binding			pancreas(1)	1						TAGAGGGAGACGTCCACTGTC	0.498		NA											7	3					0	0	0	0
DALRD3	55152	broad.mit.edu	37	3	49053902	49053902	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr3:49053902G>A	uc003cvk.1	-	8	1126	c.1106C>T	c.(1105-1107)ACC>ATC	p.T369I	DALRD3_uc003cvl.1_Missense_Mutation_p.T369I|DALRD3_uc003cvm.1_Missense_Mutation_p.T202I|DALRD3_uc010hko.1_Missense_Mutation_p.T202I|DALRD3_uc011bca.1_Missense_Mutation_p.T369I	NM_001009996	NP_001009996	Q5D0E6	DALD3_HUMAN	DALR anticodon binding domain containing 3	369					arginyl-tRNA aminoacylation	cytoplasm	arginine-tRNA ligase activity|ATP binding				0				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00218)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)		AAACTTGATGGTGGCCACAGA	0.577		NA											22	8					0	0	0	0
CCDC36	339834	broad.mit.edu	37	3	49278823	49278823	+	Splice_Site	SNP	G	G	T			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr3:49278823G>T	uc003cwk.2	+	6	782	c.395_splice	c.e6+1	p.S132_splice	CCDC36_uc003cwl.3_Splice_Site_p.S132_splice|CCDC36_uc011bck.1_Splice_Site_p.S132_splice	NM_178173	NP_835467	Q8IYA8	CCD36_HUMAN	coiled-coil domain containing 36											ovary(1)|kidney(1)	2				BRCA - Breast invasive adenocarcinoma(193;9.11e-05)|Kidney(197;0.00248)|KIRC - Kidney renal clear cell carcinoma(197;0.00262)		AATGTGACAGGTATGTAAACC	0.343		NA											13	6					1.05e-09	1.32e-09	1	0
KIAA2018	205717	broad.mit.edu	37	3	113375182	113375182	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr3:113375182G>A	uc003eam.2	-	7	5758	c.5347C>T	c.(5347-5349)CCC>TCC	p.P1783S	KIAA2018_uc003eal.2_Missense_Mutation_p.P1727S	NM_001009899	NP_001009899	Q68DE3	K2018_HUMAN	hypothetical protein LOC205717	1783					regulation of transcription, DNA-dependent	membrane|nucleus	calcium ion binding|DNA binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity			skin(2)|ovary(1)	3						ATTGGTGGGGGGCCAGTGTTT	0.418		NA											99	260					0	0	0	0
PIK3R4	30849	broad.mit.edu	37	3	130425836	130425836	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr3:130425836C>G	uc003enj.2	-	11	3258	c.2677G>C	c.(2677-2679)GAG>CAG	p.E893Q		NM_014602	NP_055417	Q99570	PI3R4_HUMAN	phosphoinositide-3-kinase, regulatory subunit 4	893					fibroblast growth factor receptor signaling pathway|innate immune response|insulin receptor signaling pathway	cytosol	ATP binding|protein binding|protein serine/threonine kinase activity			ovary(3)|lung(2)|breast(2)|skin(2)|stomach(1)|central_nervous_system(1)|kidney(1)	12						GCAGAGGACTCGGAACGAGGA	0.502		NA											3	53					0	0	0	0
PIK3CB	5291	broad.mit.edu	37	3	138400825	138400825	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr3:138400825C>T	uc011bmq.1	-	17	2488	c.2488G>A	c.(2488-2490)GCT>ACT	p.A830T	PIK3CB_uc011bmn.1_Missense_Mutation_p.A342T|PIK3CB_uc011bmo.1_Missense_Mutation_p.A281T|PIK3CB_uc011bmp.1_Missense_Mutation_p.A417T	NM_006219	NP_006210	P42338	PK3CB_HUMAN	catalytic phosphatidylinositol 3-kinase beta	830	PI3K/PI4K.				activation of MAPK activity|chemotaxis|fibroblast growth factor receptor signaling pathway|G-protein coupled receptor protein signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell receptor signaling pathway	phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity			breast(2)|ovary(1)|lung(1)|skin(1)	5						TCCAAACCAGCTTCTTTCCAG	0.363		NA											17	37					0	0	0	0
MRPS22	56945	broad.mit.edu	37	3	139069822	139069822	+	Missense_Mutation	SNP	A	A	G			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr3:139069822A>G	uc003etb.2	+	5	660	c.652A>G	c.(652-654)ATG>GTG	p.M218V	MRPS22_uc003etc.2_RNA|MRPS22_uc003etd.2_Missense_Mutation_p.M217V|MRPS22_uc003ete.2_Missense_Mutation_p.M177V	NM_020191	NP_064576	P82650	RT22_HUMAN	mitochondrial ribosomal protein S22	218						mitochondrial small ribosomal subunit	protein binding|structural constituent of ribosome			ovary(2)|skin(1)	3						GTTTTAGACTATGTATAGCCA	0.468		NA											29	86					0	0	0	0
PIK3CA	5290	broad.mit.edu	37	3	178936091	178936091	+	Missense_Mutation	SNP	G	G	A	rs104886003		TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr3:178936091G>A	uc003fjk.2	+	10	1790	c.1633G>A	c.(1633-1635)GAG>AAG	p.E545K		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	545	PI3K helical.		E -> G (in KERSEB).|E -> A (in cancer).|E -> K (in KERSEB; shows an increase in lipid kinase activity; oncogenic in vivo; occurs in the interface between the PI3K helical domain and the nSH2 (N-terminal SH2) region of the p85 regulatory subunit and may reduce the inhibitory effect of p85; requires interaction with RAS to induce cellular transformation; enhances invadopodia-mediated extracellular matrix degradation and invasion in breast cancer cells).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.E545K(735)|p.E545A(75)|p.E545G(55)|p.E545?(19)|p.E545D(15)|p.E545Q(12)|p.E545V(4)		breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			TGAAATCACTGAGCAGGAGAA	0.353	E545K(RERFLCSQ1_LUNG)|E545K(KYSE510_OESOPHAGUS)|E545K(NCIH508_LARGE_INTESTINE)|E545K(HCC202_BREAST)|E545K(BFTC909_KIDNEY)|E545K(HCT15_LARGE_INTESTINE)|E545K(NCIH596_LUNG)|E545K(L363_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|E545K(DLD1_LARGE_INTESTINE)|E545K(ESS1_ENDOMETRIUM)|E545K(MDAMB361_BREAST)|E545K(MKN1_STOMACH)|E545K(MCF7_BREAST)|E545K(NCIH460_LUNG)|E545K(TCCSUP_URINARY_TRACT)|E545K(HSC4_UPPER_AERODIGESTIVE_TRACT)|E545K(BC3C_URINARY_TRACT)|E545K(HUH28_BILIARY_TRACT)|E545K(HT1197_URINARY_TRACT)|E545K(TE5_OESOPHAGUS)	57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			13	79					0	0	0	0
DVL3	1857	broad.mit.edu	37	3	183885748	183885748	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr3:183885748C>T	uc003fms.2	+	13	1533	c.1393C>T	c.(1393-1395)CGC>TGC	p.R465C	DVL3_uc011bqw.1_Missense_Mutation_p.R448C|DVL3_uc003fmt.2_Missense_Mutation_p.R136C|DVL3_uc003fmu.2_Missense_Mutation_p.R297C	NM_004423	NP_004414	Q92997	DVL3_HUMAN	dishevelled 3	465	DEP.			R -> P (in Ref. 1; AAB47447).	canonical Wnt receptor signaling pathway|intracellular signal transduction|positive regulation of JUN kinase activity|positive regulation of protein phosphorylation|positive regulation of transcription, DNA-dependent	cytoplasm	beta-catenin binding|frizzled binding|protease binding|protein heterodimerization activity|signal transducer activity			ovary(1)|lung(1)|breast(1)	3	all_cancers(143;1.12e-10)|Ovarian(172;0.0339)		Epithelial(37;2.08e-34)|OV - Ovarian serous cystadenocarcinoma(80;1.31e-22)			GAGGGAGGCCCGCAAGTATGC	0.577		NA											41	117					0	0	0	0
ABCF3	55324	broad.mit.edu	37	3	183907447	183907447	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr3:183907447C>T	uc003fmz.2	+	13	1349	c.1216C>T	c.(1216-1218)CGG>TGG	p.R406W	ABCF3_uc003fna.2_Missense_Mutation_p.R400W|ABCF3_uc003fnb.2_Missense_Mutation_p.R87W	NM_018358	NP_060828	Q9NUQ8	ABCF3_HUMAN	ATP-binding cassette, sub-family F (GCN20),	406	ABC transporter 1.						ATP binding|ATPase activity			ovary(3)|lung(1)	4	all_cancers(143;1.12e-10)|Ovarian(172;0.0339)		Epithelial(37;2.35e-34)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			AGATGGTTACCGGGGAGACTT	0.572		NA											20	41					0	0	0	0
PIGG	54872	broad.mit.edu	37	4	499519	499519	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr4:499519G>A	uc003gak.3	+	3	509	c.373G>A	c.(373-375)GGG>AGG	p.G125R	PIGG_uc003gaj.3_Missense_Mutation_p.G125R|PIGG_uc011bux.1_RNA|PIGG_uc010ibf.2_Intron|PIGG_uc003gal.3_Missense_Mutation_p.G36R|PIGG_uc003gai.2_RNA|PIGG_uc011buw.1_Missense_Mutation_p.G3R|PIGG_uc003gam.2_Missense_Mutation_p.G36R|PIGG_uc003gan.2_Missense_Mutation_p.G36R	NM_001127178	NP_001120650	Q5H8A4	PIGG_HUMAN	phosphatidylinositol glycan anchor biosynthesis,	125	Lumenal (Potential).				C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane	CP2 mannose-ethanolamine phosphotransferase activity			central_nervous_system(2)|ovary(1)|skin(1)	4						ATTGATGACGGGGAGCCTTCC	0.428		NA											3	50					0	0	0	0
DCAF16	54876	broad.mit.edu	37	4	17805431	17805431	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr4:17805431C>T	uc003gpn.2	-	3	1395	c.334G>A	c.(334-336)GAA>AAA	p.E112K	DCAF16_uc003gpo.2_RNA	NM_017741	NP_060211	Q9NXF7	DCA16_HUMAN	DDB1 and CUL4 associated factor 16	112						CUL4 RING ubiquitin ligase complex				ovary(1)	1						GGGGGCCATTCAGGAATTGGT	0.493		NA											64	55					0	0	0	0
TLR1	7096	broad.mit.edu	37	4	38798908	38798908	+	Missense_Mutation	SNP	C	C	A			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr4:38798908C>A	uc003gtl.2	-	4	1819	c.1545G>T	c.(1543-1545)AAG>AAT	p.K515N		NM_003263	NP_003254	Q15399	TLR1_HUMAN	toll-like receptor 1 precursor	515	Extracellular (Potential).				cellular response to triacyl bacterial lipopeptide|detection of triacyl bacterial lipopeptide|inflammatory response|innate immune response|macrophage activation|positive regulation of interleukin-6 biosynthetic process|positive regulation of tumor necrosis factor biosynthetic process	integral to plasma membrane|phagocytic vesicle membrane|Toll-like receptor 1-Toll-like receptor 2 protein complex	protein heterodimerization activity|transmembrane receptor activity			lung(2)|skin(2)|prostate(1)	5						TTGACCTCATCTTCTGGCAGC	0.433		NA											121	37					1.51e-44	2.05e-44	1	0
ATP8A1	10396	broad.mit.edu	37	4	42618055	42618055	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr4:42618055G>A	uc003gwr.2	-	5	636	c.404C>T	c.(403-405)ACG>ATG	p.T135M	ATP8A1_uc003gws.2_Missense_Mutation_p.T135M|ATP8A1_uc011byz.1_Missense_Mutation_p.T135M	NM_006095	NP_006086	Q9Y2Q0	AT8A1_HUMAN	ATPase, aminophospholipid transporter (APLT),	135	Cytoplasmic (Potential).				ATP biosynthetic process	chromaffin granule membrane|integral to membrane|plasma membrane	aminophospholipid transporter activity|ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|cation-transporting ATPase activity|magnesium ion binding|phospholipid-translocating ATPase activity			skin(2)|central_nervous_system(1)	3					Phosphatidylserine(DB00144)	CCTACCTTGCGTTTGTTTCTT	0.284		NA											23	10					0	0	0	0
GRSF1	2926	broad.mit.edu	37	4	71702029	71702029	+	Silent	SNP	C	C	T			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr4:71702029C>T	uc010iia.1	-	2	443	c.360G>A	c.(358-360)GAG>GAA	p.E120E	GRSF1_uc011caz.1_Silent_p.E2E|GRSF1_uc003hfs.2_5'UTR	NM_002092	NP_002083	Q12849	GRSF1_HUMAN	G-rich RNA sequence binding factor 1 isoform 1	120					mRNA polyadenylation		mRNA binding|nucleotide binding				0		all_hematologic(202;0.21)	Lung(101;0.235)			TAGTTTTGGACTCCTTCCAAA	0.368		NA											29	53					0	0	0	0
PPEF2	5470	broad.mit.edu	37	4	76813090	76813090	+	Missense_Mutation	SNP	A	A	C			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr4:76813090A>C	uc003hix.2	-	3	454	c.97T>G	c.(97-99)TAC>GAC	p.Y33D	PPEF2_uc003hiy.2_RNA|PPEF2_uc003hiz.1_Missense_Mutation_p.Y33D	NM_006239	NP_006230	O14830	PPE2_HUMAN	serine/threonine protein phosphatase with	33	IQ.				detection of stimulus involved in sensory perception|negative regulation of MAPKKK cascade|negative regulation of peptidyl-threonine phosphorylation|protein dephosphorylation|visual perception	cytoplasm|photoreceptor inner segment|photoreceptor outer segment	calcium ion binding|Hsp70 protein binding|Hsp90 protein binding|iron ion binding|manganese ion binding|mitogen-activated protein kinase kinase kinase binding|protein serine/threonine phosphatase activity			ovary(2)|lung(1)|central_nervous_system(1)	4			Lung(101;0.0809)|LUSC - Lung squamous cell carcinoma(112;0.0934)			CGGGCCACGTAGCGCCGGTAC	0.577		NA											28	72					0	0	0	0
PDLIM5	10611	broad.mit.edu	37	4	95376534	95376534	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr4:95376534G>A	uc003hti.2	+	2	246	c.95G>A	c.(94-96)AGT>AAT	p.S32N	PDLIM5_uc003htf.2_Missense_Mutation_p.S32N|PDLIM5_uc003htg.2_Missense_Mutation_p.S32N|PDLIM5_uc011cdx.1_Missense_Mutation_p.S32N|PDLIM5_uc003hth.2_Missense_Mutation_p.S32N|PDLIM5_uc003htj.2_5'UTR|PDLIM5_uc003htk.2_Missense_Mutation_p.S32N|PDLIM5_uc011cdy.1_5'UTR	NM_006457	NP_006448	Q96HC4	PDLI5_HUMAN	PDZ and LIM domain 5 isoform a	32	PDZ.				regulation of dendritic spine morphogenesis|regulation of synaptogenesis	actin cytoskeleton|cell junction|cytosol|postsynaptic density|postsynaptic membrane|synaptosome	actin binding|actinin binding|protein kinase C binding|zinc ion binding			ovary(1)|skin(1)	2		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;1.84e-09)		ACAATCTCTAGTGTAAGTAAA	0.428		NA											15	11					0	0	0	0
FBXW7	55294	broad.mit.edu	37	4	153247289	153247289	+	Missense_Mutation	SNP	G	G	C	rs149680468		TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr4:153247289G>C	uc003ims.2	-	10	1662	c.1513C>G	c.(1513-1515)CGC>GGC	p.R505G	FBXW7_uc011cii.1_Missense_Mutation_p.R505G|FBXW7_uc003imt.2_Missense_Mutation_p.R505G|FBXW7_uc011cih.1_Missense_Mutation_p.R329G|FBXW7_uc003imq.2_Missense_Mutation_p.R425G|FBXW7_uc003imr.2_Missense_Mutation_p.R387G	NM_033632	NP_361014	Q969H0	FBXW7_HUMAN	F-box and WD repeat domain containing 7 isoform	505	WD 4.		R -> L (in an ovarian cancer cell line).		interspecies interaction between organisms|lipid homeostasis|negative regulation of DNA endoreduplication|negative regulation of hepatocyte proliferation|negative regulation of Notch signaling pathway|negative regulation of triglyceride biosynthetic process|positive regulation of epidermal growth factor receptor activity|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein stabilization|protein ubiquitination|regulation of lipid storage|regulation of protein localization|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|sister chromatid cohesion|vasculature development	nucleolus|nucleolus|nucleoplasm|nucleoplasm|SCF ubiquitin ligase complex	protein binding|protein binding	p.R505C(36)|p.R505L(6)|p.R505G(4)|p.R425C(2)|p.R425G(2)|p.R266G(2)|p.R505H(2)|p.R505S(1)|p.R505P(1)|p.R266C(1)		haematopoietic_and_lymphoid_tissue(125)|large_intestine(99)|stomach(16)|lung(14)|endometrium(13)|ovary(9)|biliary_tract(8)|upper_aerodigestive_tract(5)|central_nervous_system(3)|kidney(3)|skin(3)|pancreas(3)|breast(2)|prostate(2)|cervix(1)|NS(1)|bone(1)	308	all_hematologic(180;0.093)	Acute lymphoblastic leukemia(8;0.000629)|all_hematologic(8;0.067)				TGAACACAGCGGACTGCTGCA	0.468		NA	Mis|N|D|F		colorectal|endometrial|T-ALL								55	17					0	0	0	0
VEGFC	7424	broad.mit.edu	37	4	177605120	177605120	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr4:177605120C>T	uc003ius.1	-	7	1650	c.1220G>A	c.(1219-1221)CGT>CAT	p.R407H		NM_005429	NP_005420	P49767	VEGFC_HUMAN	vascular endothelial growth factor C	407					angiogenesis|induction of positive chemotaxis|platelet activation|platelet degranulation|positive regulation of cell division|positive regulation of mast cell chemotaxis|substrate-dependent cell migration|vascular endothelial growth factor receptor signaling pathway	membrane|platelet alpha granule lumen	chemoattractant activity|growth factor activity			lung(5)	5		Breast(14;0.000223)|Renal(120;0.00988)|Prostate(90;0.00996)|Melanoma(52;0.0101)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;1.59e-18)|Epithelial(43;3.68e-16)|OV - Ovarian serous cystadenocarcinoma(60;8.52e-09)|GBM - Glioblastoma multiforme(59;0.000546)|STAD - Stomach adenocarcinoma(60;0.00308)|Colorectal(24;0.025)|COAD - Colon adenocarcinoma(29;0.0359)|LUSC - Lung squamous cell carcinoma(193;0.0397)		AGGGACACAACGACACACTTC	0.418		NA											28	59					0	0	0	0
CDKN2AIP	55602	broad.mit.edu	37	4	184366790	184366790	+	Silent	SNP	G	G	A			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr4:184366790G>A	uc003ivp.1	+	2	537	c.375G>A	c.(373-375)GTG>GTA	p.V125V	CDKN2AIP_uc003ivq.1_Intron	NM_017632	NP_060102	Q9NXV6	CARF_HUMAN	CDKN2A interacting protein	125					negative regulation of cell growth|positive regulation of signal transduction|regulation of protein stability	granular component|nucleoplasm	double-stranded RNA binding|p53 binding				0		all_lung(41;6.9e-12)|Lung NSC(41;1.28e-11)|Colorectal(36;0.00435)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|all_hematologic(60;0.0749)		all cancers(43;1.15e-26)|Epithelial(43;2.98e-22)|OV - Ovarian serous cystadenocarcinoma(60;7.64e-10)|GBM - Glioblastoma multiforme(59;4.22e-06)|Colorectal(24;5.87e-06)|STAD - Stomach adenocarcinoma(60;2.09e-05)|COAD - Colon adenocarcinoma(29;5.15e-05)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.155)		TTGCCAAGGTGAAGAAAAGAG	0.363		NA											17	8					0	0	0	0
CCT5	22948	broad.mit.edu	37	5	10256236	10256236	+	Silent	SNP	G	G	A			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr5:10256236G>A	uc003jeq.2	+	4	672	c.501G>A	c.(499-501)CAG>CAA	p.Q167Q	CCT5_uc011cmq.1_Intron|CCT5_uc003jer.2_Silent_p.Q167Q|CCT5_uc010its.2_Silent_p.Q167Q|CCT5_uc011cmr.1_Silent_p.Q112Q|CCT5_uc011cms.1_Silent_p.Q129Q|CCT5_uc011cmt.1_Silent_p.Q74Q	NM_012073	NP_036205	P48643	TCPE_HUMAN	chaperonin containing TCP1, subunit 5 (epsilon)	167					'de novo' posttranslational protein folding|response to virus	microtubule organizing center|nucleolus	ATP binding|unfolded protein binding			ovary(2)	2						CCCTGATTCAGACAGCAAAAA	0.468		NA											22	26					0	0	0	0
COL4A3BP	10087	broad.mit.edu	37	5	74801935	74801935	+	Missense_Mutation	SNP	T	T	C			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr5:74801935T>C	uc011csu.1	-	2	525	c.103A>G	c.(103-105)AAC>GAC	p.N35D	COL4A3BP_uc003kds.2_Missense_Mutation_p.N35D|COL4A3BP_uc003kdt.2_Missense_Mutation_p.N163D|COL4A3BP_uc003kdu.2_Missense_Mutation_p.N35D	NM_005713	NP_005704	Q9Y5P4	C43BP_HUMAN	alpha 3 type IV collagen binding protein isoform	35	PH.				ER to Golgi ceramide transport|immune response	cytosol|endoplasmic reticulum membrane|Golgi apparatus	ceramide binding|phosphatidylinositol-4-phosphate binding|protein binding|protein kinase activity			skin(1)	1		all_lung(232;0.00101)|Lung NSC(167;0.00278)|Ovarian(174;0.0129)|Prostate(461;0.174)		OV - Ovarian serous cystadenocarcinoma(47;1e-53)		TGAATGTAGTTTGTCCACTGG	0.378		NA											26	4					0	0	0	0
ZFYVE16	9765	broad.mit.edu	37	5	79770505	79770505	+	Silent	SNP	G	G	A			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr5:79770505G>A	uc003kgr.3	+	18	4619	c.4317G>A	c.(4315-4317)CAG>CAA	p.Q1439Q	ZFYVE16_uc003kgq.3_Silent_p.Q1439Q|ZFYVE16_uc003kgs.3_Silent_p.Q1439Q|ZFYVE16_uc003kgt.3_Silent_p.Q527Q|ZFYVE16_uc003kgu.3_Silent_p.Q191Q	NM_001105251	NP_001098721	Q7Z3T8	ZFY16_HUMAN	zinc finger, FYVE domain containing 16	1439					BMP signaling pathway|endosome transport|protein targeting to lysosome|regulation of endocytosis|vesicle organization	early endosome membrane	1-phosphatidylinositol binding|metal ion binding|phosphatidylinositol-3,4,5-trisphosphate binding|protein binding|protein transporter activity				0		Lung NSC(167;0.00428)|all_lung(232;0.00455)|Ovarian(174;0.0261)		OV - Ovarian serous cystadenocarcinoma(54;1.6e-46)|Epithelial(54;2.02e-41)|all cancers(79;5.05e-36)		TAAAGGACCAGGATTTATCTA	0.333		NA											29	17					0	0	0	0
MEF2C	4208	broad.mit.edu	37	5	88018742	88018742	+	Silent	SNP	T	T	C			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr5:88018742T>C	uc003kjj.2	-	11	1774	c.1101A>G	c.(1099-1101)GGA>GGG	p.G367G	MEF2C_uc003kji.2_Silent_p.G359G|MEF2C_uc003kjk.2_Silent_p.G367G|MEF2C_uc003kjm.2_Silent_p.G357G|MEF2C_uc003kjl.2_Silent_p.G377G	NM_002397	NP_002388	Q06413	MEF2C_HUMAN	myocyte enhancer factor 2C isoform 1	367					apoptosis|B cell proliferation|innate immune response|learning or memory|muscle cell differentiation|muscle organ development|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|nerve growth factor receptor signaling pathway|neuron development|positive regulation of muscle cell differentiation|positive regulation of survival gene product expression|positive regulation of transcription from RNA polymerase II promoter|regulation of germinal center formation|regulation of megakaryocyte differentiation|regulation of synaptic activity|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	nuclear speck	activating transcription factor binding|protein heterodimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			lung(3)|breast(2)|ovary(1)|large_intestine(1)	7		all_cancers(142;6.67e-05)|all_epithelial(76;7.77e-07)|Lung NSC(167;0.00566)|all_lung(232;0.00732)|Colorectal(57;0.0959)|Ovarian(174;0.1)		OV - Ovarian serous cystadenocarcinoma(54;1.04e-33)|Epithelial(54;1.6e-28)|all cancers(79;2.9e-25)		TAGTGCAAGCTCTGTAGGAGG	0.463		NA								HNSCC(66;0.2)			4	7					0	0	0	0
GPR98	84059	broad.mit.edu	37	5	89988434	89988434	+	Missense_Mutation	SNP	C	C	A			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr5:89988434C>A	uc003kju.2	+	32	7060	c.6964C>A	c.(6964-6966)CAA>AAA	p.Q2322K	GPR98_uc003kjt.2_Missense_Mutation_p.Q28K|GPR98_uc003kjv.2_5'Flank	NM_032119	NP_115495	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98 precursor	2322	Calx-beta 16.|Extracellular (Potential).				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(11)|central_nervous_system(3)|pancreas(2)	16		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		TATCCAAGTGCAACTAACTGA	0.348		NA											9	4					0.00829132	0.00940253	1	0
APC	324	broad.mit.edu	37	5	112175991	112175991	+	Nonsense_Mutation	SNP	C	C	G			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr5:112175991C>G	uc010jby.2	+	16	5080	c.4700C>G	c.(4699-4701)TCA>TGA	p.S1567*	APC_uc011cvt.1_Nonsense_Mutation_p.S1549*|APC_uc003kpz.3_Nonsense_Mutation_p.S1567*|APC_uc003kpy.3_Nonsense_Mutation_p.S1567*|APC_uc010jbz.2_Nonsense_Mutation_p.S1284*|APC_uc010jca.2_Nonsense_Mutation_p.S867*	NM_001127511	NP_001120983	P25054	APC_HUMAN	adenomatous polyposis coli	1567	Ser-rich.|Asp/Glu-rich (acidic).				canonical Wnt receptor signaling pathway|cell adhesion|cell cycle arrest|cell migration|cellular component disassembly involved in apoptosis|cytokinesis after mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cyclin-dependent protein kinase activity|negative regulation of microtubule depolymerization|positive regulation of apoptosis|positive regulation of cell migration|positive regulation of pseudopodium assembly|protein complex assembly|regulation of attachment of spindle microtubules to kinetochore|response to DNA damage stimulus|tight junction assembly	adherens junction|APC-Axin-1-beta-catenin complex|Axin-APC-beta-catenin-GSK3B complex|beta-catenin destruction complex|centrosome|cytosol|kinetochore|lamellipodium|lateral plasma membrane|nucleus|ruffle membrane|tight junction	beta-catenin binding|gamma-catenin binding|microtubule plus-end binding|protein kinase binding|protein kinase regulator activity	p.K1192fs*3(1)|p.?(1)		large_intestine(2123)|stomach(123)|soft_tissue(55)|small_intestine(34)|breast(26)|pancreas(25)|urinary_tract(20)|lung(19)|thyroid(18)|liver(13)|central_nervous_system(10)|ovary(9)|skin(7)|upper_aerodigestive_tract(6)|adrenal_gland(6)|bone(6)|NS(5)|prostate(4)|endometrium(3)|kidney(1)|oesophagus(1)|biliary_tract(1)	2515		all_cancers(142;3.01e-27)|all_epithelial(76;2.3e-18)|all_hematologic(541;4.32e-09)|Ovarian(225;1.78e-06)|Lung NSC(167;0.000195)|Breast(839;0.000231)|all_lung(232;0.000247)|Colorectal(10;0.000355)|Prostate(80;0.00133)		OV - Ovarian serous cystadenocarcinoma(64;1.09e-113)|Epithelial(69;3.79e-112)|all cancers(49;1.67e-104)|BRCA - Breast invasive adenocarcinoma(61;0.00136)|COAD - Colon adenocarcinoma(37;0.00155)|Colorectal(14;0.00191)		TTAGATGATTCAGATGATGAT	0.358		12	D|Mis|N|F|S		colorectal|pancreatic|desmoid|hepatoblastoma|glioma|other CNS	colorectal|pancreatic|desmoid|hepatoblastoma|glioma|other CNS			Hereditary_Desmoid_Disease|Familial_Adenomatous_Polyposis|Turcot_syndrome	TSP Lung(16;0.13)			32	16					0	0	0	0
KIF3A	11127	broad.mit.edu	37	5	132052070	132052070	+	Missense_Mutation	SNP	T	T	C			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr5:132052070T>C	uc003kxo.2	-	7	975	c.821A>G	c.(820-822)AAT>AGT	p.N274S	KIF3A_uc003kxn.2_Missense_Mutation_p.N233S|KIF3A_uc011cxf.1_Missense_Mutation_p.N274S|KIF3A_uc003kxp.2_Missense_Mutation_p.N274S	NM_007054	NP_008985	Q9Y496	KIF3A_HUMAN	kinesin family member 3A	274	Kinesin-motor.				blood coagulation|organelle organization|plus-end-directed vesicle transport along microtubule	centrosome|cytosol|kinesin II complex|spindle microtubule	ATP binding|plus-end-directed microtubule motor activity|protein binding			pancreas(1)	1		all_cancers(142;0.0751)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			AAGTGAAAGATTGATTTTTGT	0.398		NA											3	80					0	0	0	0
SLC23A1	9963	broad.mit.edu	37	5	138707837	138707837	+	Missense_Mutation	SNP	A	A	G			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr5:138707837A>G	uc003leh.2	-	14	1752	c.1655T>C	c.(1654-1656)ATA>ACA	p.I552T	SLC23A1_uc003leg.2_Missense_Mutation_p.I556T	NM_005847	NP_005838	Q9UHI7	S23A1_HUMAN	solute carrier family 23 (nucleobase	552					brain development|nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|response to toxin|transepithelial L-ascorbic acid transport|water-soluble vitamin metabolic process	apical plasma membrane|cytoplasm|integral to plasma membrane|intracellular organelle|membrane fraction	dehydroascorbic acid transporter activity|L-ascorbate:sodium symporter activity|nucleobase transmembrane transporter activity|protein binding|sodium-dependent L-ascorbate transmembrane transporter activity				0			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00325)		Vitamin C(DB00126)	TCTTTTTACTATGCCCATCCC	0.443		NA											43	47					0	0	0	0
PCDHB11	56125	broad.mit.edu	37	5	140580820	140580820	+	Silent	SNP	C	C	A			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr5:140580820C>A	uc003liy.2	+	1	1473	c.1473C>A	c.(1471-1473)CTC>CTA	p.L491L	PCDHB11_uc011daj.1_Silent_p.L126L	NM_018931	NP_061754	Q9Y5F2	PCDBB_HUMAN	protocadherin beta 11 precursor	491	Extracellular (Potential).|Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			skin(3)|ovary(2)|upper_aerodigestive_tract(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			ACTCGCTACTCCCGCCCCAGG	0.642		NA											85	117					1.32e-40	1.79e-40	1	0
PCDHGA7	56108	broad.mit.edu	37	5	140763371	140763371	+	Nonsense_Mutation	SNP	C	C	A			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr5:140763371C>A	uc003lka.1	+	1	905	c.905C>A	c.(904-906)TCA>TAA	p.S302*	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003ljz.1_Nonsense_Mutation_p.S302*	NM_018920	NP_061743	Q9Y5G6	PCDG7_HUMAN	protocadherin gamma subfamily A, 7 isoform 1	302	Cadherin 3.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGAGAAATATCAACTTTAGAA	0.403		NA											19	36					7.08e-05	8.41e-05	1	0
FAM8A1	51439	broad.mit.edu	37	6	17600920	17600920	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr6:17600920G>A	uc003ncc.2	+	1	403	c.280G>A	c.(280-282)GAG>AAG	p.E94K		NM_016255	NP_057339	Q9UBU6	FA8A1_HUMAN	family with sequence similarity 8, member A1	94						integral to membrane					0	Breast(50;0.0259)|Ovarian(93;0.0584)	all_hematologic(90;0.143)	all cancers(50;0.176)|Epithelial(50;0.204)			GGCGGGCTGCGAGGCGCCCGA	0.731		NA											18	11					0	0	0	0
BTN3A3	10384	broad.mit.edu	37	6	26452390	26452390	+	Missense_Mutation	SNP	G	G	T			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr6:26452390G>T	uc003nhz.2	+	11	1686	c.1506G>T	c.(1504-1506)TTG>TTT	p.L502F	BTN3A3_uc003nia.2_Missense_Mutation_p.L460F|BTN3A3_uc011dkn.1_Missense_Mutation_p.L453F	NM_006994	NP_008925	O00478	BT3A3_HUMAN	butyrophilin, subfamily 3, member A3 isoform a	502	B30.2/SPRY.|Cytoplasmic (Potential).					integral to membrane					0						TCAGAATTTTGACCTTGGAGC	0.488		NA											43	123					7.53e-24	1e-23	1	0
TRIM27	5987	broad.mit.edu	37	6	28871930	28871930	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr6:28871930G>C	uc003nlr.2	-	8	1818	c.1459C>G	c.(1459-1461)CTG>GTG	p.L487V	TRIM27_uc003nls.2_3'UTR|TRIM27_uc003nlt.1_3'UTR	NM_006510	NP_006501	P14373	TRI27_HUMAN	ret finger protein	487	B30.2/SPRY.				cell proliferation|negative regulation of gene expression, epigenetic|negative regulation of transcription from RNA polymerase II promoter|protein trimerization|spermatogenesis|transcription, DNA-dependent	cytoplasm|integral to plasma membrane|membrane fraction|nuclear membrane|PML body	DNA binding|protein binding|transmembrane receptor protein tyrosine kinase activity|zinc ion binding			ovary(1)	1						CAGATGATCAGAGGAGCTGCA	0.527		NA	T	RET	papillary thyroid								57	63					0	0	0	0
TRIM40	135644	broad.mit.edu	37	6	30105123	30105123	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr6:30105123G>A	uc003npk.2	+	2	696	c.310G>A	c.(310-312)GAA>AAA	p.E104K	TRIM40_uc003npl.1_RNA|TRIM40_uc003npm.2_Missense_Mutation_p.E104K	NM_138700	NP_619645	Q6P9F5	TRI40_HUMAN	tripartite motif-containing 40	104	B box-type.					intracellular	zinc ion binding			ovary(1)	1						GTCTCATCATGAACTGACCAT	0.552		NA											61	76					0	0	0	0
PRR3	80742	broad.mit.edu	37	6	30530165	30530165	+	Splice_Site	SNP	G	G	T	rs79542230		TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr6:30530165G>T	uc003nqi.1	+	4	827	c.461_splice	c.e4-1	p.D154_splice	PRR3_uc003nqj.1_Splice_Site_p.D133_splice	NM_025263	NP_079539	P79522	PRR3_HUMAN	proline-rich protein 3 isoform a								nucleic acid binding|zinc ion binding				0						CTTGTTCACAGACAAATCCGA	0.453		NA											77	199					7.63e-38	1.03e-37	1	0
DHX16	8449	broad.mit.edu	37	6	30624230	30624230	+	Missense_Mutation	SNP	G	G	T			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr6:30624230G>T	uc003nqz.2	-	15	2580	c.2368C>A	c.(2368-2370)CTG>ATG	p.L790M	DHX16_uc003nqy.2_Missense_Mutation_p.L309M|DHX16_uc011dmo.1_Missense_Mutation_p.L730M	NM_003587	NP_003578	O60231	DHX16_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 16	790					mRNA processing|RNA splicing	nucleus	ATP binding|ATP-dependent helicase activity|nucleic acid binding|RNA helicase activity			ovary(2)|kidney(2)	4						AAAGCCAGCAGCAGTGTCTCA	0.547		NA											11	51					0.000673444	0.000779777	1	0
HTR1B	3351	broad.mit.edu	37	6	78172918	78172918	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr6:78172918G>A	uc003pil.1	-	1	203	c.203C>T	c.(202-204)GCC>GTC	p.A68V		NM_000863	NP_000854	P28222	5HT1B_HUMAN	5-hydroxytryptamine (serotonin) receptor 1B	68	Helical; Name=1; (By similarity).				G-protein signaling, coupled to cyclic nucleotide second messenger|negative regulation of cAMP biosynthetic process|synaptic transmission	integral to plasma membrane	protein binding|serotonin receptor activity				0		all_cancers(76;0.0867)|Acute lymphoblastic leukemia(125;0.00119)|all_hematologic(105;0.0332)		BRCA - Breast invasive adenocarcinoma(397;0.205)	Almotriptan(DB00918)|Dexfenfluramine(DB01191)|Dihydroergotamine(DB00320)|Eletriptan(DB00216)|Ergotamine(DB00696)|Frovatriptan(DB00998)|Naratriptan(DB00952)|Pindolol(DB00960)|Propranolol(DB00571)|Rizatriptan(DB00953)|Sumatriptan(DB00669)|Venlafaxine(DB00285)|Zolmitriptan(DB00315)	AATCACAAAGGCATTGGAGAG	0.562		NA											74	121					0	0	0	0
SLC35F1	222553	broad.mit.edu	37	6	118556746	118556746	+	Missense_Mutation	SNP	G	G	T			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr6:118556746G>T	uc003pxx.3	+	3	625	c.424G>T	c.(424-426)GCA>TCA	p.A142S		NM_001029858	NP_001025029	Q5T1Q4	S35F1_HUMAN	solute carrier family 35, member F1	142	Helical; (Potential).				transport	integral to membrane				breast(1)	1				GBM - Glioblastoma multiforme(226;0.217)		AGACCTGGAAGCAAATTATCT	0.423		NA											23	37					1.28e-07	1.58e-07	1	0
TCF21	6943	broad.mit.edu	37	6	134210616	134210616	+	Silent	SNP	G	G	A			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr6:134210616G>A	uc003qei.3	+	1	357	c.81G>A	c.(79-81)TCG>TCA	p.S27S	uc003qeg.1_5'Flank|TCF21_uc003qej.2_Silent_p.S27S	NM_003206	NP_003197	O43680	TCF21_HUMAN	transcription factor 21	27					branching involved in ureteric bud morphogenesis|mesoderm development|negative regulation of androgen receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent	nucleus	androgen receptor binding|E-box binding|protein dimerization activity|sequence-specific DNA binding transcription factor activity				0	Colorectal(23;0.221)|Breast(56;0.247)			GBM - Glioblastoma multiforme(68;0.00518)|OV - Ovarian serous cystadenocarcinoma(155;0.00783)		AAATGGATTCGAACAAGGAAT	0.562		NA											44	57					0	0	0	0
FBXO30	84085	broad.mit.edu	37	6	146126431	146126431	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr6:146126431C>T	uc003qla.2	-	2	1310	c.1111G>A	c.(1111-1113)GAC>AAC	p.D371N	uc003qky.1_Intron	NM_032145	NP_115521	Q8TB52	FBX30_HUMAN	F-box only protein 30	371							ubiquitin-protein ligase activity|zinc ion binding			ovary(2)|large_intestine(1)	3		Ovarian(120;0.0776)		OV - Ovarian serous cystadenocarcinoma(155;1.95e-07)|GBM - Glioblastoma multiforme(68;0.0149)		TCCCCTAAGTCTACTTTTTTC	0.388		NA											53	76					0	0	0	0
CARD11	84433	broad.mit.edu	37	7	2962348	2962348	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr7:2962348G>A	uc003smv.2	-	17	2593	c.2189C>T	c.(2188-2190)ACA>ATA	p.T730I		NM_032415	NP_115791	Q9BXL7	CAR11_HUMAN	caspase recruitment domain family, member 11	730	PDZ.				positive regulation of cytokine production|positive regulation of NF-kappaB transcription factor activity|regulation of apoptosis|T cell costimulation|T cell receptor signaling pathway	cytosol|membrane raft|plasma membrane	CARD domain binding|guanylate kinase activity			haematopoietic_and_lymphoid_tissue(43)|ovary(2)|kidney(2)|skin(2)|central_nervous_system(1)	50		Ovarian(82;0.0115)		OV - Ovarian serous cystadenocarcinoma(56;8.44e-14)		TTTGGTGCATGTGTCCAACGG	0.622		NA	Mis		DLBCL								7	48					0	0	0	0
RADIL	55698	broad.mit.edu	37	7	4917456	4917456	+	Silent	SNP	C	C	T			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr7:4917456C>T	uc003snj.1	-	2	488	c.315G>A	c.(313-315)AGG>AGA	p.R105R	RADIL_uc003sng.1_RNA|RADIL_uc011jwd.1_RNA	NM_018059	NP_060529	Q96JH8	RADIL_HUMAN	Rap GTPase interactor	105	Ras-associating.				cell adhesion|multicellular organismal development|signal transduction		protein binding			lung(2)|central_nervous_system(2)|pancreas(2)|breast(1)	7		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0986)|OV - Ovarian serous cystadenocarcinoma(56;7.41e-15)		GGCCGGCCTGCCTGGGGTCCA	0.682		NA											38	74					0	0	0	0
FSCN1	6624	broad.mit.edu	37	7	5632776	5632776	+	Missense_Mutation	SNP	T	T	A			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr7:5632776T>A	uc003sou.2	+	1	323	c.209T>A	c.(208-210)CTG>CAG	p.L70Q		NM_003088	NP_003079	Q16658	FSCN1_HUMAN	fascin 1	70					actin filament bundle assembly|cell migration|cell proliferation	cell junction|cytoplasm|filopodium|invadopodium|stress fiber	actin filament binding|drug binding|protein binding, bridging			ovary(1)	1		Ovarian(82;0.0694)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0986)|OV - Ovarian serous cystadenocarcinoma(56;1.21e-13)		GGCCGCTACCTGGCGGCGGAC	0.706		NA											4	10					0	0	0	0
RSPH10B2	728194	broad.mit.edu	37	7	5968017	5968017	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr7:5968017C>T	uc003sph.1	-	20	2513	c.2242G>A	c.(2242-2244)GAG>AAG	p.E748K	RSPH10B2_uc003spg.1_Missense_Mutation_p.E595K|RSPH10B2_uc010ktd.1_Missense_Mutation_p.E748K|RSPH10B2_uc011jwk.1_Missense_Mutation_p.M369I	NM_173565	NP_775836	B2RC85	R10B2_HUMAN	radial spoke head 10 homolog B	748										ovary(1)|pancreas(1)|skin(1)	3						TTGGGTCTCTCATATTTCTCT	0.443		NA											67	172					0	0	0	0
AOAH	313	broad.mit.edu	37	7	36633994	36633994	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr7:36633994C>G	uc003tfh.3	-	12	1290	c.889G>C	c.(889-891)GAC>CAC	p.D297H	AOAH_uc010kxf.2_Missense_Mutation_p.D297H|AOAH_uc011kba.1_Missense_Mutation_p.D265H	NM_001637	NP_001628	P28039	AOAH_HUMAN	acyloxyacyl hydrolase precursor	297					inflammatory response|lipid metabolic process	extracellular region	acyloxyacyl hydrolase activity|lipoprotein lipase activity			skin(1)	1						TGGGGCCAGTCAAGCTCGTTG	0.408		NA											31	79					0	0	0	0
RFC2	5982	broad.mit.edu	37	7	73649972	73649972	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr7:73649972G>A	uc003uaj.2	-	10	869	c.844C>T	c.(844-846)CTT>TTT	p.L282F	RFC2_uc011kfa.1_RNA|RFC2_uc003uak.2_Missense_Mutation_p.L248F|RFC2_uc010lbp.2_Missense_Mutation_p.L211F|RFC2_uc003ual.2_Missense_Mutation_p.L181F	NM_181471	NP_852136	P35250	RFC2_HUMAN	replication factor C 2 isoform 1	282					cell cycle checkpoint|DNA strand elongation involved in DNA replication|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	DNA replication factor C complex|nucleoplasm	ATP binding|DNA clamp loader activity|protein binding			liver(1)|central_nervous_system(1)	2						AAGTGAGCAAGAATCTAGACA	0.448		NA											37	64					0	0	0	0
PCLO	27445	broad.mit.edu	37	7	82584860	82584860	+	Silent	SNP	A	A	G			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr7:82584860A>G	uc003uhx.2	-	5	5698	c.5409T>C	c.(5407-5409)TCT>TCC	p.S1803S	PCLO_uc003uhv.2_Silent_p.S1803S	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	1734					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						ATTTTTTACTAGAACTCTTTC	0.378		NA											60	81					0	0	0	0
CCDC132	55610	broad.mit.edu	37	7	92869194	92869194	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr7:92869194C>G	uc003umo.2	+	2	177	c.49C>G	c.(49-51)CAA>GAA	p.Q17E	CCDC132_uc003umq.2_RNA|CCDC132_uc003ump.2_5'UTR|CCDC132_uc003umr.2_RNA|CCDC132_uc011khz.1_Missense_Mutation_p.Q17E|CCDC132_uc003umn.2_Missense_Mutation_p.Q17E	NM_017667	NP_060137	Q96JG6	CC132_HUMAN	coiled-coil domain containing 132 isoform a	17											0	all_cancers(62;2.64e-11)|all_epithelial(64;1.4e-10)|Breast(17;0.000675)|Lung NSC(181;0.0618)|all_lung(186;0.0837)		STAD - Stomach adenocarcinoma(171;0.000302)			GAAAAGCCCTCAAGAAAGCCT	0.378		NA											62	113					0	0	0	0
TAF6	6878	broad.mit.edu	37	7	99711345	99711345	+	Silent	SNP	G	G	A			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr7:99711345G>A	uc003uti.2	-	4	372	c.291C>T	c.(289-291)GCC>GCT	p.A97A	TAF6_uc003utg.2_Silent_p.A38A|TAF6_uc003uth.2_Silent_p.A154A|TAF6_uc003utk.2_Silent_p.A97A|TAF6_uc011kji.1_Silent_p.A134A|TAF6_uc003utj.2_Silent_p.A87A|TAF6_uc003utl.2_Silent_p.A97A|TAF6_uc003utm.2_Silent_p.A97A|TAF6_uc003utn.1_RNA	NM_139315	NP_647476	P49848	TAF6_HUMAN	TBP-associated factor 6 isoform alpha	97					negative regulation of cell cycle|negative regulation of cell proliferation|regulation of sequence-specific DNA binding transcription factor activity|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	cytoplasm|MLL1 complex|transcription factor TFIID complex|transcription factor TFIID complex|transcription factor TFTC complex	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(1)|central_nervous_system(1)	2	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					CCCCACCAGAGGCGAAGCGGA	0.607		NA											5	29					0	0	0	0
MUC17	140453	broad.mit.edu	37	7	100677499	100677499	+	Silent	SNP	G	G	A			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr7:100677499G>A	uc003uxp.1	+	3	2855	c.2802G>A	c.(2800-2802)ACG>ACA	p.T934T	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	934	Extracellular (Potential).|Ser-rich.|59 X approximate tandem repeats.|13.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					ACAGCACCACGCCGGTAGTCA	0.512		NA											257	346					0	0	0	0
EXOC4	60412	broad.mit.edu	37	7	133689722	133689722	+	Silent	SNP	G	G	T			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr7:133689722G>T	uc003vrk.2	+	16	2441	c.2406G>T	c.(2404-2406)GTG>GTT	p.V802V	EXOC4_uc011kpo.1_Silent_p.V701V|EXOC4_uc003vrl.2_Silent_p.V412V|EXOC4_uc011kpp.1_Silent_p.V334V|EXOC4_uc011kpq.1_Silent_p.V90V	NM_021807	NP_068579	Q96A65	EXOC4_HUMAN	SEC8 protein isoform a	802					vesicle docking involved in exocytosis	exocyst	protein N-terminus binding			ovary(4)|large_intestine(3)|upper_aerodigestive_tract(1)|skin(1)	9		Esophageal squamous(399;0.129)				ATGCCATTGTGGCTAATGTGG	0.463		NA											7	99					2.01e-06	2.45e-06	1	0
UBN2	254048	broad.mit.edu	37	7	138968956	138968956	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr7:138968956G>C	uc011kqr.1	+	15	3305	c.3305G>C	c.(3304-3306)AGC>ACC	p.S1102T		NM_173569	NP_775840	Q6ZU65	UBN2_HUMAN	ubinuclein 2	1102	Ser-rich.									ovary(1)|skin(1)	2						GCCCAGGGTAGCCACTCCAGC	0.473		NA											59	66					0	0	0	0
HTR5A	3361	broad.mit.edu	37	7	154862903	154862903	+	Silent	SNP	G	G	A			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr7:154862903G>A	uc003wlu.1	+	1	358	c.294G>A	c.(292-294)CTG>CTA	p.L98L	uc011kvt.1_Silent_p.T37T|uc003wlt.2_Silent_p.T37T	NM_024012	NP_076917	P47898	5HT5A_HUMAN	5-hydroxytryptamine receptor 5A	98	Helical; Name=2; (By similarity).					integral to plasma membrane	serotonin receptor activity			ovary(2)|large_intestine(1)	3	all_neural(206;0.119)	all_hematologic(28;0.0592)	OV - Ovarian serous cystadenocarcinoma(82;0.0238)	UCEC - Uterine corpus endometrioid carcinoma (81;0.171)		CGCTGAGCCTGGTGCACGAGC	0.672		NA											8	31					0	0	0	0
SGK223	157285	broad.mit.edu	37	8	8234394	8234394	+	Nonsense_Mutation	SNP	C	C	A			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr8:8234394C>A	uc003wsh.3	-	2	1525	c.1525G>T	c.(1525-1527)GAG>TAG	p.E509*		NM_001080826	NP_001074295	Q86YV5	SG223_HUMAN	pragmin	509							ATP binding|non-membrane spanning protein tyrosine kinase activity				0						TCACCTACCTCGGAGTTCTGG	0.652		NA											13	8					0.000219431	0.000256781	1	0
BAG4	9530	broad.mit.edu	37	8	38034614	38034614	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr8:38034614G>A	uc003xky.1	+	1	509	c.227G>A	c.(226-228)GGA>GAA	p.G76E	LSM1_uc003xkw.2_5'Flank|LSM1_uc003xkx.2_5'Flank|BAG4_uc003xkz.1_Missense_Mutation_p.G76E	NM_004874	NP_004865	O95429	BAG4_HUMAN	BCL2-associated athanogene 4	76					anti-apoptosis|apoptosis|protein folding	cytoplasm|nucleus	receptor signaling protein activity			ovary(1)	1	Colorectal(12;0.000442)	all_lung(54;0.00787)|Lung NSC(58;0.0295)|Hepatocellular(245;0.121)				TATCCCTCGGGAGGCGCCTGG	0.706		NA											21	6					0	0	0	0
XKR4	114786	broad.mit.edu	37	8	56270346	56270346	+	Silent	SNP	G	G	T			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr8:56270346G>T	uc003xsf.2	+	2	947	c.915G>T	c.(913-915)CTG>CTT	p.L305L		NM_052898	NP_443130	Q5GH76	XKR4_HUMAN	XK, Kell blood group complex subunit-related	305						integral to membrane				pancreas(2)	2			Epithelial(17;0.000117)|all cancers(17;0.000836)			TGAGTATGCTGCATTTGCTAG	0.473		NA											43	37					2.2e-31	2.94e-31	1	0
CLVS1	157807	broad.mit.edu	37	8	62212732	62212732	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr8:62212732C>T	uc003xuh.2	+	2	670	c.346C>T	c.(346-348)CCC>TCC	p.P116S	CLVS1_uc003xug.2_Missense_Mutation_p.P116S|CLVS1_uc003xui.2_Intron|CLVS1_uc010lyp.2_Missense_Mutation_p.P116S	NM_173519	NP_775790	Q8IUQ0	CLVS1_HUMAN	retinaldehyde binding protein 1-like 1	116					lysosome organization	clathrin-coated vesicle|early endosome membrane|trans-Golgi network	phosphatidylinositol-3,5-bisphosphate binding|transporter activity			skin(4)|ovary(1)	5						GGCAGATGATCCCGGCATTAA	0.507		NA											21	60					0	0	0	0
PREX2	80243	broad.mit.edu	37	8	68934274	68934274	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr8:68934274G>A	uc003xxv.1	+	4	367	c.340G>A	c.(340-342)GAC>AAC	p.D114N	PREX2_uc003xxu.1_Missense_Mutation_p.D114N|PREX2_uc011lez.1_Missense_Mutation_p.D49N	NM_024870	NP_079146	Q70Z35	PREX2_HUMAN	DEP domain containing 2 isoform a	114	DH.				G-protein coupled receptor protein signaling pathway|intracellular signal transduction	intracellular	protein binding|Rac GTPase activator activity|Rac guanyl-nucleotide exchange factor activity			skin(6)|large_intestine(4)|pancreas(3)|lung(2)|ovary(1)|kidney(1)	17						TTCACAGAAAGACAAGTTTCG	0.259		NA											19	29					0	0	0	0
E2F5	1875	broad.mit.edu	37	8	86121536	86121536	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr8:86121536C>G	uc003ycz.3	+	6	812	c.775C>G	c.(775-777)CCA>GCA	p.P259A	E2F5_uc003yda.3_Missense_Mutation_p.P259A|E2F5_uc010mab.2_Missense_Mutation_p.P98A|E2F5_uc003ydb.3_Missense_Mutation_p.P78A	NM_001951	NP_001942	Q15329	E2F5_HUMAN	E2F transcription factor 5 isoform 1	259					G1 phase of mitotic cell cycle	transcription factor complex	DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding			ovary(1)	1						GTCCTTGACTCCAGTGACTCC	0.488		NA											5	94					0	0	0	0
PSKH2	85481	broad.mit.edu	37	8	87076791	87076791	+	Silent	SNP	G	G	T			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr8:87076791G>T	uc011lfy.1	-	2	255	c.255C>A	c.(253-255)ACC>ACA	p.T85T		NM_033126	NP_149117	Q96QS6	KPSH2_HUMAN	protein serine kinase H2	85	Protein kinase.						ATP binding|protein serine/threonine kinase activity			stomach(2)|lung(2)|ovary(1)	5			STAD - Stomach adenocarcinoma(118;0.129)			AAGGTTTCTTGGTGGTCTTCT	0.483		NA											28	109					8.58e-18	1.13e-17	1	0
FAM82B	51115	broad.mit.edu	37	8	87519250	87519250	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr8:87519250G>A	uc003ydu.2	-	2	381	c.221C>T	c.(220-222)GCT>GTT	p.A74V	FAM82B_uc011lfz.1_Missense_Mutation_p.A74V|FAM82B_uc011lga.1_Missense_Mutation_p.A74V	NM_016033	NP_057117	Q96DB5	RMD1_HUMAN	regulator of microtubule dynamics 1	74						microtubule|spindle pole	binding			ovary(1)	1						AACCACAGCAGCCTGAGAGAT	0.368		NA											93	150					0	0	0	0
RUNX1T1	862	broad.mit.edu	37	8	92999130	92999130	+	Missense_Mutation	SNP	C	C	A			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr8:92999130C>A	uc003yfd.2	-	7	1146	c.1062G>T	c.(1060-1062)TGG>TGT	p.W354C	RUNX1T1_uc003yfc.1_Missense_Mutation_p.W327C|RUNX1T1_uc003yfe.1_Missense_Mutation_p.W317C|RUNX1T1_uc010mao.2_Missense_Mutation_p.W327C|RUNX1T1_uc011lgi.1_Missense_Mutation_p.W365C|RUNX1T1_uc010man.1_5'UTR|RUNX1T1_uc003yfb.1_Missense_Mutation_p.W317C	NM_175634	NP_783552	Q06455	MTG8_HUMAN	acute myelogenous leukemia 1 translocation 1	354	Important for oligomerization.				generation of precursor metabolites and energy	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(9)|large_intestine(3)|breast(2)|central_nervous_system(1)|pancreas(1)	16			BRCA - Breast invasive adenocarcinoma(11;0.0141)			CAAGATGTTTCCACTCTTCTG	0.378		NA											6	215					0.00116845	0.00134585	1	0
FAM92A1	137392	broad.mit.edu	37	8	94713483	94713483	+	Missense_Mutation	SNP	G	G	T			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr8:94713483G>T	uc010maq.2	+	2	161	c.58G>T	c.(58-60)GTC>TTC	p.V20F	FAM92A1_uc003yfu.1_RNA|FAM92A1_uc003yfv.3_RNA	NM_145269	NP_660312	A1XBS5	F92A1_HUMAN	hypothetical protein LOC137392	20											0	Breast(36;2.4e-06)		BRCA - Breast invasive adenocarcinoma(8;0.0168)			GCAAACAGCTGTCTCAAATGT	0.453		NA											10	41					2.81e-09	3.52e-09	1	0
VPS13B	157680	broad.mit.edu	37	8	100513954	100513954	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr8:100513954G>A	uc003yiv.2	+	26	4021	c.3910G>A	c.(3910-3912)GAT>AAT	p.D1304N	VPS13B_uc003yiw.2_Missense_Mutation_p.D1304N|VPS13B_uc003yiu.1_Missense_Mutation_p.D1304N|VPS13B_uc003yix.1_Missense_Mutation_p.D774N	NM_017890	NP_060360	Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13B isoform 5	1304					protein transport					ovary(7)|skin(4)|lung(3)|central_nervous_system(2)|pancreas(2)|breast(1)|kidney(1)	20	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			ACCATTCTCAGATTCTGTGAC	0.368		NA											95	129					0	0	0	0
EIF3E	3646	broad.mit.edu	37	8	109252300	109252300	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr8:109252300C>G	uc003ymu.2	-	3	238	c.210G>C	c.(208-210)TTG>TTC	p.L70F	EIF3E_uc003ymt.2_Missense_Mutation_p.L21F|EIF3E_uc003ymv.2_5'UTR|EIF3E_uc010mci.1_Missense_Mutation_p.L70F|EIF3E_uc010mcj.1_Missense_Mutation_p.L70F	NM_001568	NP_001559	P60228	EIF3E_HUMAN	eukaryotic translation initiation factor 3,	70	Sufficient for interaction with TRIM27.|Sufficient for interaction with EPAS1.				negative regulation of translational initiation|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	cytosol|eukaryotic translation initiation factor 3 complex|PML body	protein N-terminus binding			ovary(2)|kidney(1)	3			OV - Ovarian serous cystadenocarcinoma(57;6.84e-10)			TTTTCTCTCTCAAAGCTAATT	0.358		NA											30	126					0	0	0	0
CSMD3	114788	broad.mit.edu	37	8	113323395	113323395	+	Missense_Mutation	SNP	G	G	T			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr8:113323395G>T	uc003ynu.2	-	50	7856	c.7697C>A	c.(7696-7698)GCT>GAT	p.A2566D	CSMD3_uc003yns.2_Missense_Mutation_p.A1768D|CSMD3_uc003ynt.2_Missense_Mutation_p.A2526D|CSMD3_uc011lhx.1_Missense_Mutation_p.A2462D|CSMD3_uc003ynw.1_Missense_Mutation_p.A277D	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	2566	CUB 14.|Extracellular (Potential).					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						ACAGTAGAAAGCTTTTCAAAA	0.398		NA								HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			15	59					4.93e-13	6.34e-13	1	0
MYC	4609	broad.mit.edu	37	8	128753051	128753051	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr8:128753051G>C	uc003ysi.2	+	3	1737	c.1212G>C	c.(1210-1212)AAG>AAC	p.K404N		NM_002467	NP_002458	P01106	MYC_HUMAN	myc proto-oncogene protein	389	Helix-loop-helix motif.				branching involved in ureteric bud morphogenesis|cell cycle arrest|cell proliferation|cellular iron ion homeostasis|positive regulation of metanephric cap mesenchymal cell proliferation|positive regulation of transcription, DNA-dependent|regulation of telomere maintenance|regulation of transcription from RNA polymerase II promoter|response to drug	nucleolus|nucleoplasm	E-box binding|protein binding|sequence-specific DNA binding transcription factor activity			lung(3)|ovary(1)|central_nervous_system(1)|pancreas(1)	6	all_cancers(1;6.19e-134)|all_epithelial(1;1.75e-119)|all_lung(1;5.66e-51)|Breast(1;1.08e-22)|all_neural(1;4.45e-21)|Medulloblastoma(1;1.88e-20)|Colorectal(1;1.92e-09)|Lung SC(1;4.52e-07)|Ovarian(5;0.000122)|Esophageal squamous(12;0.000995)|Renal(1;0.0921)|Hepatocellular(40;0.108)|Myeloproliferative disorder(2;0.135)|Melanoma(291;0.185)	Myeloproliferative disorder(644;0.0255)|Ovarian(118;0.0654)|Breast(495;0.212)|Acute lymphoblastic leukemia(644;0.22)	Epithelial(1;1.63e-94)|all cancers(1;5.82e-87)|OV - Ovarian serous cystadenocarcinoma(1;2.12e-71)|BRCA - Breast invasive adenocarcinoma(1;4.3e-14)|Lung(2;0.000381)|Colorectal(2;0.0102)|LUAD - Lung adenocarcinoma(14;0.0172)|READ - Rectum adenocarcinoma(2;0.0723)|LUSC - Lung squamous cell carcinoma(258;0.151)	KIRC - Kidney renal clear cell carcinoma(542;0.248)		ACAATGAAAAGGCCCCCAAGG	0.502		3	A|T	IGK@|BCL5|BCL7A |BTG1|TRA@|IGH@	Burkitt lymphoma| amplified in other cancers|B-CLL								64	305					0	0	0	0
ASAP1	50807	broad.mit.edu	37	8	131073299	131073299	+	Silent	SNP	T	T	C			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr8:131073299T>C	uc003yta.1	-	27	2746	c.2718A>G	c.(2716-2718)ACA>ACG	p.T906T	ASAP1_uc003ysz.1_Silent_p.T717T|ASAP1_uc011liw.1_Silent_p.T899T	NM_018482	NP_060952	Q9ULH1	ASAP1_HUMAN	development and differentiation enhancing factor	906	Pro-rich.				cilium morphogenesis|filopodium assembly|regulation of ARF GTPase activity|signal transduction	cytoplasm|membrane	ARF GTPase activator activity|cytoskeletal adaptor activity|SH3 domain binding|zinc ion binding			ovary(4)	4						AGAGATGATCTGTTTTCCTTA	0.493		NA											83	271					0	0	0	0
OC90	729330	broad.mit.edu	37	8	133036916	133036916	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr8:133036916G>A	uc003ytg.2	-	13	1246	c.1246C>T	c.(1246-1248)CTC>TTC	p.L416F	OC90_uc011lix.1_Missense_Mutation_p.L416F	NM_001080399	NP_001073868	Q02509	OC90_HUMAN	otoconin 90	432	Phospholipase A2-like 3.				lipid catabolic process|phospholipid metabolic process		calcium ion binding|phospholipase A2 activity			ovary(2)|skin(1)	3	Esophageal squamous(12;0.00693)|Ovarian(258;0.00769)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000805)			GGGCACCCGAGTCTGCTTGGG	0.627		NA											10	36					0	0	0	0
KDM4C	23081	broad.mit.edu	37	9	6805612	6805612	+	Missense_Mutation	SNP	A	A	T			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr9:6805612A>T	uc003zkh.2	+	3	738	c.158A>T	c.(157-159)AAG>ATG	p.K53M	KDM4C_uc010mhu.2_Missense_Mutation_p.K75M|KDM4C_uc010mhw.2_Missense_Mutation_p.K53M|KDM4C_uc011lmi.1_Missense_Mutation_p.K53M|KDM4C_uc011lmj.1_RNA|KDM4C_uc003zkg.2_Missense_Mutation_p.K53M|KDM4C_uc011lmk.1_Intron|KDM4C_uc010mhv.2_Missense_Mutation_p.K53M	NM_015061	NP_055876	Q9H3R0	KDM4C_HUMAN	jumonji domain containing 2C isoform 1	53	JmjN.				positive regulation of cell proliferation|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|transcription, DNA-dependent	nuclear chromatin	androgen receptor binding|enzyme binding|histone demethylase activity (H3-K9 specific)|nucleic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|zinc ion binding			ovary(1)	1						ATTCCTCCTAAGGAGTGGAAG	0.358		NA											19	4					0	0	0	0
CYLC2	1539	broad.mit.edu	37	9	105767308	105767308	+	Nonsense_Mutation	SNP	C	C	G			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr9:105767308C>G	uc004bbs.2	+	5	465	c.395C>G	c.(394-396)TCA>TGA	p.S132*		NM_001340	NP_001331	Q14093	CYLC2_HUMAN	cylicin 2	132	31 X 3 AA repeats of K-K-X.				cell differentiation|multicellular organismal development|spermatogenesis	cytoskeletal calyx	structural constituent of cytoskeleton			skin(1)	1		all_hematologic(171;0.125)				GATTCGGAATCAGAATTAaaa	0.179		NA											6	27					0	0	0	0
PTPN3	5774	broad.mit.edu	37	9	112168829	112168829	+	Missense_Mutation	SNP	C	C	G	rs59324117	byFrequency	TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr9:112168829C>G	uc004bed.2	-	18	1817	c.1705G>C	c.(1705-1707)GAA>CAA	p.E569Q	PTPN3_uc004beb.2_Missense_Mutation_p.E438Q|PTPN3_uc004bec.2_Missense_Mutation_p.E393Q|PTPN3_uc010mtu.2_RNA|PTPN3_uc011lwg.1_Missense_Mutation_p.E524Q|PTPN3_uc011lwh.1_Missense_Mutation_p.E415Q|PTPN3_uc011lwd.1_Missense_Mutation_p.E37Q|PTPN3_uc011lwe.1_Missense_Mutation_p.E282Q|PTPN3_uc011lwf.1_Missense_Mutation_p.E237Q	NM_002829	NP_002820	P26045	PTN3_HUMAN	protein tyrosine phosphatase, non-receptor type	569	PDZ.				negative regulation of membrane protein ectodomain proteolysis|negative regulation of mitotic cell cycle	cytoplasm|cytoskeleton|internal side of plasma membrane	ATPase binding|cytoskeletal protein binding|phosphotyrosine binding|protein tyrosine phosphatase activity			ovary(3)	3						TGCGTGTGTTCTGAGATGTCC	0.557		NA											87	134					0	0	0	0
PALM2-AKAP2	445815	broad.mit.edu	37	9	112899008	112899008	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr9:112899008G>A	uc004bei.2	+	9	2072	c.1880G>A	c.(1879-1881)CGA>CAA	p.R627Q	PALM2-AKAP2_uc004bek.3_Missense_Mutation_p.R395Q|PALM2-AKAP2_uc004bej.3_Missense_Mutation_p.R395Q|PALM2-AKAP2_uc004bel.1_Missense_Mutation_p.R205Q|AKAP2_uc011lwi.1_Missense_Mutation_p.R253Q|AKAP2_uc004bem.2_Missense_Mutation_p.R253Q|PALM2-AKAP2_uc010mtw.1_Missense_Mutation_p.R213Q|AKAP2_uc011lwj.1_Missense_Mutation_p.R164Q|PALM2-AKAP2_uc004ben.2_Missense_Mutation_p.R164Q	NM_001136562	NP_001130034	Q9Y2D5	AKAP2_HUMAN	A kinase (PRKA) anchor protein 2 isoform 2	164							enzyme binding			ovary(3)|central_nervous_system(2)|skin(1)	6						TGTTCTTCCCGAGATGGAGAG	0.572		NA											47	9					0	0	0	0
DBC1	1620	broad.mit.edu	37	9	121929820	121929820	+	Missense_Mutation	SNP	T	T	G			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr9:121929820T>G	uc004bkc.2	-	8	2284	c.1828A>C	c.(1828-1830)ACA>CCA	p.T610P		NM_014618	NP_055433	O60477	DBC1_HUMAN	deleted in bladder cancer 1 precursor	610					cell cycle arrest|cell death	cytoplasm	protein binding			skin(3)|ovary(2)|central_nervous_system(2)|large_intestine(1)	8						TCGAAAAATGTTTTCCACCGA	0.557		NA											116	29					0	0	0	0
MAGEB6	158809	broad.mit.edu	37	X	26212041	26212041	+	Silent	SNP	G	G	C			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chrX:26212041G>C	uc004dbr.2	+	2	227	c.78G>C	c.(76-78)ACG>ACC	p.T26T	MAGEB6_uc010ngc.1_5'UTR	NM_173523	NP_775794	Q8N7X4	MAGB6_HUMAN	melanoma antigen family B, 6	26										ovary(3)	3						AGGGTCTCACGGGTCCCCAGG	0.572		NA											30	16					0	0	0	0
MAGED1	9500	broad.mit.edu	37	X	51639730	51639730	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chrX:51639730C>T	uc004dpm.2	+	4	1074	c.979C>T	c.(979-981)CAG>TAG	p.Q327*	MAGED1_uc004dpn.2_Nonsense_Mutation_p.Q383*|MAGED1_uc004dpo.2_Nonsense_Mutation_p.Q327*	NM_001005332	NP_001005332	Q9Y5V3	MAGD1_HUMAN	melanoma antigen family D, 1 isoform b	327	Pro-rich.|22 X 6 AA tandem repeats of W-[PQ]-X-P-X- X.				apoptosis|induction of apoptosis by extracellular signals|negative regulation of epithelial cell proliferation|nerve growth factor receptor signaling pathway|regulation of transcription, DNA-dependent	cytoplasm|plasma membrane|protein complex	protein binding			ovary(3)	3	Ovarian(276;0.236)					TCCAGCTAGGCAGACCCCACC	0.602		NA								Multiple Myeloma(10;0.10)			30	9					0	0	0	0
NRK	203447	broad.mit.edu	37	X	105179222	105179222	+	Missense_Mutation	SNP	T	T	C			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chrX:105179222T>C	uc004emd.2	+	21	3863	c.3560T>C	c.(3559-3561)GTT>GCT	p.V1187A	NRK_uc010npc.1_Missense_Mutation_p.V855A	NM_198465	NP_940867	Q7Z2Y5	NRK_HUMAN	Nik related kinase	1187							ATP binding|protein serine/threonine kinase activity|small GTPase regulator activity			breast(7)|ovary(3)|lung(2)|large_intestine(1)|central_nervous_system(1)	14						GAAGTCAATGTTAACCCACTC	0.418		NA								HNSCC(51;0.14)			61	26					0	0	0	0
GPR112	139378	broad.mit.edu	37	X	135439890	135439890	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chrX:135439890G>C	uc004ezu.1	+	10	7246	c.6955G>C	c.(6955-6957)GCT>CCT	p.A2319P	GPR112_uc010nsb.1_Missense_Mutation_p.A2114P|GPR112_uc010nsc.1_Intron	NM_153834	NP_722576	Q8IZF6	GP112_HUMAN	G-protein coupled receptor 112	2319	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(5)|large_intestine(2)|skin(2)|lung(1)|breast(1)|pancreas(1)	12	Acute lymphoblastic leukemia(192;0.000127)					ACAAGAAATGGCTACAATTTC	0.348		NA											5	126					0	0	0	0
AHDC1	27245	broad.mit.edu	37	1	27875791	27875792	+	Frame_Shift_Ins	INS	-	-	G			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr1:27875791_27875792insG	uc009vsy.2	-	6	3804_3805	c.2835_2836insC	c.(2833-2838)CCCAAGfs	p.P945fs	AHDC1_uc009vsz.1_Frame_Shift_Ins_p.P945fs	NM_001029882	NP_001025053	Q5TGY3	AHDC1_HUMAN	AT hook, DNA binding motif, containing 1	945_946							DNA binding			central_nervous_system(1)	1		all_lung(284;1.06e-05)|Lung NSC(340;1.86e-05)|Colorectal(325;3.46e-05)|Renal(390;0.0007)|Breast(348;0.0021)|Ovarian(437;0.00503)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0434)|OV - Ovarian serous cystadenocarcinoma(117;8.48e-25)|Colorectal(126;9.17e-09)|COAD - Colon adenocarcinoma(152;1.84e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.00192)|BRCA - Breast invasive adenocarcinoma(304;0.00259)|STAD - Stomach adenocarcinoma(196;0.00311)|READ - Rectum adenocarcinoma(331;0.0291)		GGCACCAGCTTGGGGAAGGTCT	0.678		NA											56	33	---	---	---	---	NA	NA	NA	NA
SLC6A9	6536	broad.mit.edu	37	1	44467092	44467094	+	In_Frame_Del	DEL	GAA	GAA	-			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr1:44467092_44467094delGAA	uc001cll.2	-	9	1579_1581	c.1387_1389delTTC	c.(1387-1389)TTCdel	p.F463del	SLC6A9_uc009vxe.2_In_Frame_Del_p.F319del|SLC6A9_uc010okm.1_In_Frame_Del_p.F390del|SLC6A9_uc001clm.2_In_Frame_Del_p.F409del|SLC6A9_uc009vxd.2_RNA|SLC6A9_uc010okn.1_In_Frame_Del_p.F394del|SLC6A9_uc001cln.2_In_Frame_Del_p.F390del|SLC6A9_uc010oko.1_In_Frame_Del_p.F279del|SLC6A9_uc010okp.1_RNA	NM_201649	NP_964012	P48067	SC6A9_HUMAN	solute carrier family 6 member 9 isoform 2	463	Helical; Name=8; (Potential).					integral to plasma membrane|membrane fraction	glycine:sodium symporter activity|neurotransmitter:sodium symporter activity				0	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0511)			Glycine(DB00145)	GGATAAGCATGAAGAAGAAGAGC	0.64		NA											29	68	---	---	---	---	NA	NA	NA	NA
SLITRK5	26050	broad.mit.edu	37	13	88328028	88328029	+	Frame_Shift_Ins	INS	-	-	G			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr13:88328028_88328029insG	uc001vln.2	+	2	604_605	c.385_386insG	c.(385-387)CGGfs	p.R129fs	SLITRK5_uc010tic.1_Intron	NM_015567	NP_056382	O94991	SLIK5_HUMAN	SLIT and NTRK-like family, member 5 precursor	129	Extracellular (Potential).					integral to membrane				ovary(2)|pancreas(2)|central_nervous_system(1)	5	all_neural(89;0.101)|Medulloblastoma(90;0.163)					CCATGGGCTACGGGGTTTGAGG	0.45		NA											71	108	---	---	---	---	NA	NA	NA	NA
TP53	7157	broad.mit.edu	37	17	7577032	7577033	+	Frame_Shift_Del	DEL	CC	CC	-			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr17:7577032_7577033delCC	uc002gim.2	-	8	1099_1100	c.905_906delGG	c.(904-906)GGGfs	p.G302fs	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Frame_Shift_Del_p.G302fs|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Frame_Shift_Del_p.G170fs|TP53_uc010cng.1_Frame_Shift_Del_p.G170fs|TP53_uc002gii.1_Frame_Shift_Del_p.G170fs|TP53_uc010cnh.1_Frame_Shift_Del_p.G302fs|TP53_uc010cni.1_Frame_Shift_Del_p.G302fs|TP53_uc002gij.2_Frame_Shift_Del_p.G302fs	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	302	Interaction with HIPK1 (By similarity).|Interaction with CARM1.		G -> R (in a sporadic cancer; somatic mutation).|G -> E (in sporadic cancers; somatic mutation).|G -> A (in a sporadic cancer; somatic mutation).|G -> V (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.0?(7)|p.G302fs*4(4)|p.?(3)|p.G302E(3)|p.G302G(3)|p.P301_S303delPGS(1)|p.L299fs*2(1)|p.L265_K305del41(1)|p.G302fs*2(1)|p.S303fs*42(1)|p.G293fs*1(1)|p.H296_S303delHHELPPGS(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GCTTAGTGCTCCCTGGGGGCAG	0.554		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			43	70	---	---	---	---	NA	NA	NA	NA
AKAP1	8165	broad.mit.edu	37	17	55189196	55189197	+	Frame_Shift_Ins	INS	-	-	T			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr17:55189196_55189197insT	uc002iux.2	+	4	2117_2118	c.1886_1887insT	c.(1885-1887)TATfs	p.Y629fs	AKAP1_uc010wnl.1_Frame_Shift_Ins_p.Y629fs|AKAP1_uc002iuy.2_RNA|AKAP1_uc010dcm.2_Frame_Shift_Ins_p.Y629fs	NM_003488	NP_003479	Q92667	AKAP1_HUMAN	A-kinase anchor protein 1 precursor	629	KH.				blood coagulation	cytosol|integral to membrane|mitochondrial outer membrane	protein binding|RNA binding			ovary(1)	1	Breast(9;5.46e-08)					CAGGGGCGCTATGTGAGTTTTC	0.48		NA											86	100	---	---	---	---	NA	NA	NA	NA
MARK4	57787	broad.mit.edu	37	19	45762300	45762300	+	Frame_Shift_Del	DEL	C	C	-			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr19:45762300delC	uc002pbb.1	+	2	110	c.105delC	c.(103-105)AGCfs	p.S35fs	MARK4_uc002paz.1_Intron|MARK4_uc002pba.1_Frame_Shift_Del_p.S35fs			Q96L34	MARK4_HUMAN	RecName: Full=MAP/microtubule affinity-regulating kinase 4;          EC=2.7.11.1; AltName: Full=MAP/microtubule affinity-regulating kinase-like 1;	35					microtubule bundle formation|nervous system development|positive regulation of programmed cell death	centrosome|neuron projection	ATP binding|gamma-tubulin binding|microtubule binding|protein serine/threonine kinase activity|tau-protein kinase activity|ubiquitin binding			central_nervous_system(2)|large_intestine(1)	3		all_neural(266;0.224)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.0102)		CCTGGTCCAGCCGCTCACTGG	0.662		NA											16	28	---	---	---	---	NA	NA	NA	NA
ACSS2	55902	broad.mit.edu	37	20	33502206	33502206	+	Frame_Shift_Del	DEL	C	C	-			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr20:33502206delC	uc002xbd.2	+	7	921	c.800delC	c.(799-801)TCCfs	p.S267fs	ACSS2_uc002xbc.2_Frame_Shift_Del_p.S172fs|ACSS2_uc010zum.1_Intron|ACSS2_uc010gey.2_Frame_Shift_Del_p.S267fs|ACSS2_uc002xbe.2_Intron|ACSS2_uc002xbf.2_Intron	NM_018677	NP_061147	Q9NR19	ACSA_HUMAN	acyl-CoA synthetase short-chain family member 2	267					ethanol oxidation|lipid biosynthetic process|xenobiotic metabolic process	cytosol|nucleus	acetate-CoA ligase activity|ATP binding|protein binding				0					Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)	ACCAGCCAGTCCCCCCCAATT	0.537		NA											20	64	---	---	---	---	NA	NA	NA	NA
ETV5	2119	broad.mit.edu	37	3	185797720	185797721	+	Frame_Shift_Ins	INS	-	-	G			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr3:185797720_185797721insG	uc003fpz.2	-	7	782_783	c.535_536insC	c.(535-537)CATfs	p.H179fs	ETV5_uc003fpy.2_Frame_Shift_Ins_p.H221fs	NM_004454	NP_004445	P41161	ETV5_HUMAN	ets variant gene 5 (ets-related molecule)	179					cellular response to oxidative stress	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			ovary(2)|skin(2)|breast(1)	5	all_cancers(143;4.06e-12)|Ovarian(172;0.0386)|Breast(254;0.247)		OV - Ovarian serous cystadenocarcinoma(80;1.62e-24)			TGGAAGCGAATGGGGGGCGGGG	0.614		NA	T	TMPRSS2|SCL45A3	Prostate 								40	181	---	---	---	---	NA	NA	NA	NA
RREB1	6239	broad.mit.edu	37	6	7211049	7211071	+	Frame_Shift_Del	DEL	CCATGAGAAGGACCCTAACAGTG	CCATGAGAAGGACCCTAACAGTG	-	rs145494137		TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr6:7211049_7211071delCCATGAGAAGGACCCTAACAGTG	uc003mxc.2	+	7	828_850	c.438_460delCCATGAGAAGGACCCTAACAGTG	c.(436-462)ATCCATGAGAAGGACCCTAACAGTGCCfs	p.I146fs	RREB1_uc010jnw.2_Frame_Shift_Del_p.I146fs|RREB1_uc003mxb.2_Frame_Shift_Del_p.I146fs|RREB1_uc010jnx.2_Frame_Shift_Del_p.I146fs|RREB1_uc003mxd.2_Frame_Shift_Del_p.I146fs	NM_001003698	NP_001003698	Q92766	RREB1_HUMAN	ras responsive element binding protein 1 isoform	146_154					multicellular organismal development|positive regulation of transcription, DNA-dependent|Ras protein signal transduction|transcription from RNA polymerase II promoter	cytoplasm|nuclear speck	DNA binding|zinc ion binding			ovary(4)|large_intestine(2)|pancreas(2)|skin(2)|breast(1)	11	Ovarian(93;0.0398)	all_hematologic(90;0.0384)|Prostate(151;0.191)				ATATGAAGATCCATGAGAAGGACCCTAACAGTGCCACAGCCAC	0.439		NA											12	87	---	---	---	---	NA	NA	NA	NA
HIST1H1B	3009	broad.mit.edu	37	6	27835121	27835121	+	Frame_Shift_Del	DEL	C	C	-			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr6:27835121delC	uc003njx.2	-	1	239	c.187delG	c.(187-189)GCAfs	p.A63fs		NM_005322	NP_005313	P16401	H15_HUMAN	histone cluster 1, H1b	63	H15.				nucleosome assembly	nucleosome|nucleus	DNA binding			large_intestine(2)|lung(1)	3						TTAAGGGCTGCCAAAGAAAGG	0.607		NA											14	166	---	---	---	---	NA	NA	NA	NA
RP1L1	94137	broad.mit.edu	37	8	10467489	10467503	+	In_Frame_Del	DEL	CTGCACCCCCTCTTC	CTGCACCCCCTCTTC	-	rs146799763	by1000genomes	TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr8:10467489_10467503delCTGCACCCCCTCTTC	uc003wtc.2	-	4	4334_4348	c.4105_4119delGAAGAGGGGGTGCAG	c.(4105-4119)GAAGAGGGGGTGCAGdel	p.EEGVQ1369del		NM_178857	NP_849188	Q8IWN7	RP1L1_HUMAN	retinitis pigmentosa 1-like 1	1369_1373					intracellular signal transduction					ovary(4)|breast(3)|central_nervous_system(1)	8				COAD - Colon adenocarcinoma(149;0.0811)		CTTCCTCTAACTGCACCCCCTCTTCTTGCAGCCct	0.307		NA											10	201	---	---	---	---	NA	NA	NA	NA
PLEC	5339	broad.mit.edu	37	8	144992466	144992479	+	Frame_Shift_Del	DEL	GCTGGGCTCTGACA	GCTGGGCTCTGACA	-			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr8:144992466_144992479delGCTGGGCTCTGACA	uc003zaf.1	-	32	12091_12104	c.11921_11934delTGTCAGAGCCCAGC	c.(11920-11934)CTGTCAGAGCCCAGCfs	p.L3974fs	PLEC_uc003zab.1_Frame_Shift_Del_p.L3837fs|PLEC_uc003zac.1_Frame_Shift_Del_p.L3841fs|PLEC_uc003zad.2_Frame_Shift_Del_p.L3837fs|PLEC_uc003zae.1_Frame_Shift_Del_p.L3805fs|PLEC_uc003zag.1_Frame_Shift_Del_p.L3815fs|PLEC_uc003zah.2_Frame_Shift_Del_p.L3823fs|PLEC_uc003zaj.2_Frame_Shift_Del_p.L3864fs	NM_201380	NP_958782	Q15149	PLEC_HUMAN	plectin isoform 1	3974_3978	Plectin 21.|Globular 2.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle|structural constituent of muscle			large_intestine(2)|ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	9						TGCGCACCTCGCTGGGCTCTGACAGCTGGTCGTG	0.692		NA											9	26	---	---	---	---	NA	NA	NA	NA
LRRC19	64922	broad.mit.edu	37	9	26999638	26999640	+	In_Frame_Del	DEL	ATA	ATA	-			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr9:26999638_26999640delATA	uc003zqh.2	-	2	164_166	c.53_55delTAT	c.(52-57)TTATCA>TCA	p.L18del	IFT74_uc010mja.2_Intron|IFT74_uc010mjb.2_Intron|IFT74_uc003zqf.3_Intron|IFT74_uc003zqg.3_Intron	NM_022901	NP_075052	Q9H756	LRC19_HUMAN	leucine rich repeat containing 19 precursor	18						integral to membrane					0		all_neural(11;1.81e-09)		Lung(218;1.06e-05)|LUSC - Lung squamous cell carcinoma(38;0.0001)		ATTTTGTCTGATAATAATATCAT	0.291		NA											14	20	---	---	---	---	NA	NA	NA	NA