Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	isArtifactMode	oxoGCut
PRDM16	63976	broad.mit.edu	37	1	3322204	3322204	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr1:3322204C>T	uc001akf.2	+	8	1258	c.1178C>T	c.(1177-1179)CCT>CTT	p.P393L	PRDM16_uc001akc.2_Missense_Mutation_p.P393L|PRDM16_uc001akd.2_Missense_Mutation_p.P393L|PRDM16_uc001ake.2_Missense_Mutation_p.P393L|PRDM16_uc009vlh.2_Missense_Mutation_p.P94L	NM_022114	NP_071397	Q9HAZ2	PRD16_HUMAN	PR domain containing 16 isoform 1	393					brown fat cell differentiation|negative regulation of granulocyte differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transforming growth factor beta receptor signaling pathway|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|regulation of cellular respiration|transcription, DNA-dependent	transcriptional repressor complex	protein binding|sequence-specific DNA binding|transcription coactivator activity|zinc ion binding			lung(3)|ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	7	all_cancers(77;0.00208)|all_epithelial(69;0.000732)|Ovarian(185;0.0634)|Lung NSC(156;0.109)|all_lung(157;0.111)	all_epithelial(116;2.03e-21)|all_lung(118;7.55e-09)|Lung NSC(185;1.28e-06)|Breast(487;0.000792)|Renal(390;0.00137)|Hepatocellular(190;0.00515)|Myeloproliferative disorder(586;0.0267)|Ovarian(437;0.0365)|Lung SC(97;0.114)|Medulloblastoma(700;0.134)		Epithelial(90;5.59e-35)|OV - Ovarian serous cystadenocarcinoma(86;1.99e-20)|GBM - Glioblastoma multiforme(42;3.72e-11)|Colorectal(212;0.000425)|BRCA - Breast invasive adenocarcinoma(365;0.000946)|COAD - Colon adenocarcinoma(227;0.000968)|Kidney(185;0.00155)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0175)|Lung(427;0.137)		ACGGTGAAGCCTTTCATATGT	0.701		NA	T	EVI1	MDS|AML								14	76					0	0	0	0
CASZ1	54897	broad.mit.edu	37	1	10719786	10719786	+	Missense_Mutation	SNP	A	A	T			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr1:10719786A>T	uc001aro.2	-	6	1633	c.1313T>A	c.(1312-1314)ATC>AAC	p.I438N	CASZ1_uc001arp.1_Missense_Mutation_p.I438N|CASZ1_uc009vmx.2_Missense_Mutation_p.I462N|CASZ1_uc001arq.1_Missense_Mutation_p.I297N	NM_001079843	NP_001073312	Q86V15	CASZ1_HUMAN	castor homolog 1, zinc finger isoform a	438					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			skin(1)	1	Ovarian(185;0.203)|all_lung(157;0.204)	Lung NSC(185;4.96e-06)|all_lung(284;1.22e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00212)|Hepatocellular(190;0.00913)|Ovarian(437;0.0229)|Myeloproliferative disorder(586;0.0255)	STAD - Stomach adenocarcinoma(5;0.0224)	UCEC - Uterine corpus endometrioid carcinoma (279;0.0265)|Colorectal(212;3.54e-08)|COAD - Colon adenocarcinoma(227;9.56e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000219)|Kidney(185;0.00142)|KIRC - Kidney renal clear cell carcinoma(229;0.00381)|READ - Rectum adenocarcinoma(331;0.0419)|STAD - Stomach adenocarcinoma(132;0.0623)		CCCCGTGGTGATGGAGTCTGT	0.632		NA											13	60					0	0	0	0
RPF1	80135	broad.mit.edu	37	1	84946675	84946675	+	Missense_Mutation	SNP	A	A	G			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr1:84946675A>G	uc001djv.3	+	2	310	c.265A>G	c.(265-267)AGA>GGA	p.R89G		NM_025065	NP_079341	Q9H9Y2	RPF1_HUMAN	RNA processing factor 1	89					rRNA processing|translation	nucleolus	aminoacyl-tRNA ligase activity|ATP binding|rRNA binding				0						TAAAAAAGAAAGAGAGGCTCT	0.303		NA											29	35					0	0	0	0
COL11A1	1301	broad.mit.edu	37	1	103480090	103480090	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr1:103480090G>C	uc001dul.2	-	13	1867	c.1549C>G	c.(1549-1551)CAA>GAA	p.Q517E	COL11A1_uc001duk.2_5'UTR|COL11A1_uc001dum.2_Missense_Mutation_p.Q529E|COL11A1_uc001dun.2_Missense_Mutation_p.Q478E|COL11A1_uc009weh.2_Missense_Mutation_p.Q401E	NM_001854	NP_001845	P12107	COBA1_HUMAN	alpha 1 type XI collagen isoform A	517	Telopeptide.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			ovary(6)|breast(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	12		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		AGAATAGCTTGAGCCTGAGCT	0.418		NA											8	31					0	0	0	0
RPTN	126638	broad.mit.edu	37	1	152128471	152128471	+	Missense_Mutation	SNP	A	A	T			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr1:152128471A>T	uc001ezs.1	-	3	1169	c.1104T>A	c.(1102-1104)AGT>AGA	p.S368R		NM_001122965	NP_001116437	Q6XPR3	RPTN_HUMAN	repetin	368	Gln-rich.					proteinaceous extracellular matrix	calcium ion binding				0						TGTTTGGTTGACTGTAGTGGG	0.463		NA											151	749					0	0	0	0
NUP210L	91181	broad.mit.edu	37	1	154029336	154029336	+	Silent	SNP	C	C	T			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr1:154029336C>T	uc001fdw.2	-	23	3267	c.3195G>A	c.(3193-3195)AAG>AAA	p.K1065K	NUP210L_uc009woq.2_Intron|NUP210L_uc010peh.1_Silent_p.K1065K	NM_207308	NP_997191	Q5VU65	P210L_HUMAN	nucleoporin 210kDa-like isoform 1	1065						integral to membrane				skin(5)|ovary(4)|large_intestine(1)|central_nervous_system(1)	11	all_lung(78;9.35e-31)|Lung NSC(65;1.33e-28)|Hepatocellular(266;0.0877)|Melanoma(130;0.128)		LUSC - Lung squamous cell carcinoma(543;0.151)|Colorectal(543;0.198)			CCATCTTGTCCTTGGCAATAG	0.388		NA											6	66					0	0	0	0
FCRL4	83417	broad.mit.edu	37	1	157557696	157557696	+	Missense_Mutation	SNP	T	T	A			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr1:157557696T>A	uc001fqw.2	-	4	657	c.521A>T	c.(520-522)AAT>ATT	p.N174I	FCRL4_uc010phy.1_Intron	NM_031282	NP_112572	Q96PJ5	FCRL4_HUMAN	Fc receptor-like 4 precursor	174	Extracellular (Potential).|Ig-like C2-type 2.					integral to membrane|plasma membrane	receptor activity			ovary(2)|kidney(1)|skin(1)	4	all_hematologic(112;0.0378)|Hepatocellular(266;0.178)	Prostate(1639;0.245)				AAATACATCATTCTCGTCTCC	0.318		NA											6	19					0	0	0	0
KIRREL	55243	broad.mit.edu	37	1	158046036	158046036	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr1:158046036G>C	uc001frn.3	+	2	590	c.186G>C	c.(184-186)ATG>ATC	p.M62I	KIRREL_uc010pib.1_Intron|KIRREL_uc009wsq.2_Missense_Mutation_p.M1I	NM_018240	NP_060710	Q96J84	KIRR1_HUMAN	kin of IRRE like precursor	62	Extracellular (Potential).|Ig-like C2-type 1.					integral to membrane				ovary(1)	1	all_hematologic(112;0.0378)					CCCTGGGCATGGGCCAGGGCC	0.602		NA											40	98					0	0	0	0
USP21	27005	broad.mit.edu	37	1	161130531	161130531	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr1:161130531G>A	uc010pke.1	+	3	478	c.101G>A	c.(100-102)CGC>CAC	p.R34H	USP21_uc010pkc.1_Missense_Mutation_p.R34H|USP21_uc010pkd.1_Missense_Mutation_p.R34H|USP21_uc010pkf.1_Missense_Mutation_p.R34H	NM_001014443	NP_001014443	Q9UK80	UBP21_HUMAN	ubiquitin-specific protease 21	34					histone deubiquitination|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent|ubiquitin-dependent protein catabolic process	nucleus	metal ion binding|NEDD8-specific protease activity|protein binding|transcription coactivator activity|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(2)|lung(1)|prostate(1)|breast(1)	5	all_cancers(52;3.73e-19)|Breast(13;0.000577)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00275)			CCCAGGGCCCGCAGCAAGGAG	0.632		NA											43	88					0	0	0	0
PIK3C2B	5287	broad.mit.edu	37	1	204403072	204403072	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr1:204403072C>T	uc001haw.2	-	26	4171	c.3692G>A	c.(3691-3693)CGT>CAT	p.R1231H	PIK3C2B_uc010pqv.1_Missense_Mutation_p.R1203H	NM_002646	NP_002637	O00750	P3C2B_HUMAN	phosphoinositide-3-kinase, class 2 beta	1231	PI3K/PI4K.				cell communication|phosphatidylinositol-mediated signaling	endoplasmic reticulum|microsome|nucleus|phosphatidylinositol 3-kinase complex|plasma membrane	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity|protein binding			lung(2)|breast(2)|stomach(1)|prostate(1)|central_nervous_system(1)	7	all_cancers(21;0.00347)|all_neural(3;0.0218)|Glioma(3;0.0382)|all_epithelial(62;0.171)|Breast(84;0.179)|Prostate(682;0.227)		GBM - Glioblastoma multiforme(2;2.69e-45)|all cancers(3;1.66e-30)|KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.143)|Epithelial(59;0.193)			AAAGGGGGCACGGTCCCTGAG	0.557		NA											8	62					0	0	0	0
MTR	4548	broad.mit.edu	37	1	237060420	237060420	+	Splice_Site	SNP	T	T	C			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr1:237060420T>C	uc001hyi.3	+	32	4134	c.3711_splice	c.e32+2	p.Q1237_splice	MTR_uc010pxw.1_Splice_Site_p.Q830_splice|MTR_uc010pxx.1_Splice_Site_p.Q1186_splice|MTR_uc010pxy.1_Splice_Site_p.Q1091_splice	NM_000254	NP_000245	Q99707	METH_HUMAN	5-methyltetrahydrofolate-homocysteine						nervous system development|xenobiotic metabolic process	cytosol	cobalamin binding|homocysteine S-methyltransferase activity|methionine synthase activity|protein binding|zinc ion binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3	Ovarian(103;0.0634)|Breast(184;0.221)	all_cancers(173;2.79e-22)|all_epithelial(177;4.84e-14)|Breast(1374;0.00123)|Prostate(94;0.0181)|Lung SC(1967;0.0262)|Acute lymphoblastic leukemia(190;0.117)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)	KIRC - Kidney renal clear cell carcinoma(1967;0.248)	Hydroxocobalamin(DB00200)|L-Methionine(DB00134)|Tetrahydrofolic acid(DB00116)	AAGGATCAGGTAAGCTAGCTG	0.403		NA											19	99					0	0	0	0
SVIL	6840	broad.mit.edu	37	10	29824982	29824982	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr10:29824982G>C	uc001iut.1	-	7	1597	c.844C>G	c.(844-846)CAT>GAT	p.H282D	SVIL_uc001iuu.1_Intron|SVIL_uc009xld.1_Missense_Mutation_p.H282D	NM_021738	NP_068506	O95425	SVIL_HUMAN	supervillin isoform 2	282					cytoskeleton organization|skeletal muscle tissue development	cell junction|costamere|invadopodium|nucleus|podosome	actin filament binding			ovary(5)|upper_aerodigestive_tract(1)	6		Breast(68;0.103)				AACCACTCATGTTTGGGTTTC	0.433		NA									OREG0020098	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	9	49					0	0	0	0
BLNK	29760	broad.mit.edu	37	10	97976475	97976475	+	Missense_Mutation	SNP	G	G	T			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr10:97976475G>T	uc001kls.3	-	7	719	c.541C>A	c.(541-543)CCC>ACC	p.P181T	BLNK_uc001kme.3_Missense_Mutation_p.P99T|BLNK_uc001klt.3_Missense_Mutation_p.P95T|BLNK_uc009xvc.2_RNA|BLNK_uc001klu.3_Missense_Mutation_p.P99T|BLNK_uc001klv.3_Intron|BLNK_uc001klw.3_RNA|BLNK_uc001klx.3_Missense_Mutation_p.P181T|BLNK_uc001kly.3_Missense_Mutation_p.P181T|BLNK_uc001klz.3_RNA|BLNK_uc001kma.3_Missense_Mutation_p.P181T|BLNK_uc001kmb.3_5'UTR|BLNK_uc001kmc.3_RNA|BLNK_uc001kmd.3_Missense_Mutation_p.P99T|BLNK_uc009xvd.2_RNA	NM_013314	NP_037446	Q8WV28	BLNK_HUMAN	B-cell linker isoform 1	181	Pro-rich.				B cell differentiation|humoral immune response|inflammatory response|intracellular signal transduction	cytoplasm|plasma membrane	SH3/SH2 adaptor activity|transmembrane receptor protein tyrosine kinase adaptor activity			skin(2)	2		Colorectal(252;0.083)		Epithelial(162;7.89e-08)|all cancers(201;2.27e-06)		TCTTCCACGGGGACCACATAA	0.368		NA											8	27					0.000157383	0.000282733	1	0
SEMA4G	57715	broad.mit.edu	37	10	102740948	102740948	+	Missense_Mutation	SNP	A	A	G			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr10:102740948A>G	uc001krw.1	+	13	2051	c.1667A>G	c.(1666-1668)GAG>GGG	p.E556G	SEMA4G_uc001krv.2_RNA|SEMA4G_uc001krx.2_Missense_Mutation_p.E556G|MRPL43_uc001kry.1_Intron|MRPL43_uc010qpu.1_Intron	NM_017893	NP_060363	Q9NTN9	SEM4G_HUMAN	semaphorin 4G	551	Extracellular (Potential).|PSI.				cell differentiation|nervous system development	integral to membrane	receptor activity			breast(1)	1		Colorectal(252;0.234)		Epithelial(162;3.71e-09)|all cancers(201;2.1e-07)		CAGGACATAGAGAGAGGAAAT	0.483		NA											7	56					0	0	0	0
KCNQ1	3784	broad.mit.edu	37	11	2594162	2594162	+	Silent	SNP	C	C	T			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr11:2594162C>T	uc001lwn.2	+	6	975	c.867C>T	c.(865-867)AAC>AAT	p.N289N	KCNQ1_uc009ydp.1_Silent_p.N73N|KCNQ1_uc001lwo.2_Silent_p.N162N	NM_000218	NP_000209	P51787	KCNQ1_HUMAN	potassium voltage-gated channel, KQT-like	289	Extracellular (Potential).				blood circulation|membrane depolarization|muscle contraction|sensory perception of sound		delayed rectifier potassium channel activity|protein binding			ovary(1)	1		all_epithelial(84;3.26e-05)|Breast(177;0.001)|Medulloblastoma(188;0.00111)|Ovarian(85;0.00158)|all_neural(188;0.00725)|all_lung(207;0.11)|Lung NSC(207;0.159)		BRCA - Breast invasive adenocarcinoma(625;0.00251)|Lung(200;0.131)	Bepridil(DB01244)|Indapamide(DB00808)	ACGCGGTGAACGAGTCAGGCC	0.597		NA											15	19					0	0	0	0
OR5M9	390162	broad.mit.edu	37	11	56230205	56230205	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr11:56230205G>A	uc010rjj.1	-	1	673	c.673C>T	c.(673-675)CGC>TGC	p.R225C		NM_001004743	NP_001004743	Q8NGP3	OR5M9_HUMAN	olfactory receptor, family 5, subfamily M,	225	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)|central_nervous_system(1)	4	Esophageal squamous(21;0.00448)					GAGCGCATGCGTAGCACAGCT	0.478		NA											7	10					0	0	0	0
MUS81	80198	broad.mit.edu	37	11	65631092	65631092	+	Silent	SNP	G	G	C			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr11:65631092G>C	uc001ofv.3	+	9	1214	c.861G>C	c.(859-861)CTG>CTC	p.L287L	MUS81_uc001ofw.3_RNA|MUS81_uc001ofx.3_5'UTR	NM_025128	NP_079404	Q96NY9	MUS81_HUMAN	MUS81 endonuclease homolog	287	ERCC4.				DNA recombination|DNA repair	nucleolus	3'-flap endonuclease activity|DNA binding|metal ion binding|protein binding				0				READ - Rectum adenocarcinoma(159;0.166)		GGCCGGAGCTGCTCCGAGAGC	0.632		NA						Homologous_recombination					3	28					0	0	0	0
DPP3	10072	broad.mit.edu	37	11	66262860	66262860	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr11:66262860G>C	uc001oig.1	+	14	1539	c.1477G>C	c.(1477-1479)GAG>CAG	p.E493Q	DPP3_uc001oif.1_Missense_Mutation_p.E493Q|DPP3_uc010rpe.1_Missense_Mutation_p.E482Q|DPP3_uc001oih.1_5'Flank	NM_005700	NP_005691	Q9NY33	DPP3_HUMAN	dipeptidyl peptidase III	493					proteolysis	cytoplasm	aminopeptidase activity|dipeptidyl-peptidase activity|metal ion binding|metallopeptidase activity			ovary(1)|skin(1)	2						TCGGAGCGGGGAGACCTGGGA	0.622		NA											4	27					0	0	0	0
ACTN3	89	broad.mit.edu	37	11	66326764	66326764	+	Missense_Mutation	SNP	G	G	T			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr11:66326764G>T	uc001oio.1	+	12	1352	c.1334G>T	c.(1333-1335)CGG>CTG	p.R445L	ACTN3_uc010rpi.1_RNA	NM_001104	NP_001095	Q08043	ACTN3_HUMAN	actinin, alpha 3	445	Spectrin 2.				focal adhesion assembly|muscle filament sliding|regulation of apoptosis	actin filament|cytosol|focal adhesion|pseudopodium	actin binding|calcium ion binding|integrin binding|protein homodimerization activity|structural constituent of muscle				0						CAGGAGGTGCGGGCGTTGCTG	0.647		NA											9	44					1.77e-08	3.36e-08	1	0
PC	5091	broad.mit.edu	37	11	66617734	66617734	+	Missense_Mutation	SNP	T	T	C			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr11:66617734T>C	uc001ojn.1	-	17	2724	c.2675A>G	c.(2674-2676)AAG>AGG	p.K892R	PC_uc001ojo.1_Missense_Mutation_p.K892R|PC_uc001ojp.1_Missense_Mutation_p.K892R|PC_uc001ojm.1_5'Flank	NM_022172	NP_071504	P11498	PYC_HUMAN	pyruvate carboxylase precursor	892					gluconeogenesis|lipid biosynthetic process	mitochondrial matrix	ATP binding|biotin binding|biotin carboxylase activity|metal ion binding|pyruvate carboxylase activity			ovary(2)|lung(1)|kidney(1)	4		Melanoma(852;0.0525)		Lung(977;0.153)|LUSC - Lung squamous cell carcinoma(976;0.227)	Biotin(DB00121)|Pyruvic acid(DB00119)	CACATAGGCCTTCTTGACCTC	0.602		NA											11	41					0	0	0	0
CHKA	1119	broad.mit.edu	37	11	67821473	67821473	+	Silent	SNP	C	C	T			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr11:67821473C>T	uc001onj.2	-	12	1570	c.1356G>A	c.(1354-1356)AAG>AAA	p.K452K	CHKA_uc001onk.2_Silent_p.K434K	NM_001277	NP_001268	P35790	CHKA_HUMAN	choline kinase alpha isoform a	452					lipid transport|phosphatidylethanolamine biosynthetic process	cytoplasm	ATP binding|choline kinase activity|drug binding|ethanolamine kinase activity|signal transducer activity			ovary(1)|central_nervous_system(1)	2					Choline(DB00122)	CAAGCTTCCTCTTCTGGTGGA	0.577		NA											5	16					0	0	0	0
VPS11	55823	broad.mit.edu	37	11	118938701	118938701	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr11:118938701G>A	uc010ryx.1	+	1	209	c.167G>A	c.(166-168)CGA>CAA	p.R56Q	VPS11_uc010ryy.1_5'UTR	NM_021729	NP_068375	Q9H270	VPS11_HUMAN	vacuolar protein sorting 11	56					protein transport	endocytic vesicle|HOPS complex|late endosome membrane|lysosomal membrane	nucleotide binding|protein binding|zinc ion binding			ovary(2)|central_nervous_system(1)	3	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.88e-05)		GACTCAGGCCGAGGGAGCCTG	0.577		NA											4	10					0	0	0	0
ERC1	23085	broad.mit.edu	37	12	1289706	1289706	+	Missense_Mutation	SNP	A	A	C			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr12:1289706A>C	uc001qjb.2	+	9	1979	c.1738A>C	c.(1738-1740)ATT>CTT	p.I580L	ERC1_uc001qiz.2_RNA|ERC1_uc001qjc.2_Missense_Mutation_p.I552L|ERC1_uc001qja.2_RNA|ERC1_uc001qjd.2_RNA|ERC1_uc001qjf.2_Missense_Mutation_p.I580L|ERC1_uc010sdv.1_Missense_Mutation_p.I328L|ERC1_uc009zdp.2_Missense_Mutation_p.I220L	NM_178040	NP_829884	Q8IUD2	RB6I2_HUMAN	RAB6-interacting protein 2 isoform epsilon	580	Potential.				I-kappaB phosphorylation|multicellular organismal development|positive regulation of anti-apoptosis|positive regulation of NF-kappaB transcription factor activity|protein transport	Golgi membrane|IkappaB kinase complex|presynaptic membrane	leucine zipper domain binding			ovary(2)|lung(2)|breast(1)	5	all_epithelial(11;0.0698)|Ovarian(42;0.107)		OV - Ovarian serous cystadenocarcinoma(31;0.00239)|BRCA - Breast invasive adenocarcinoma(9;0.0567)			GTACATTTAGATTGAAAATCT	0.368		NA											17	32					0	0	0	0
GDF3	9573	broad.mit.edu	37	12	7843292	7843292	+	Missense_Mutation	SNP	G	G	T			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr12:7843292G>T	uc001qte.2	-	2	313	c.277C>A	c.(277-279)CTT>ATT	p.L93I		NM_020634	NP_065685	Q9NR23	GDF3_HUMAN	growth differentiation factor 3 precursor	93					eye development|growth|skeletal system development	extracellular space	cytokine activity|growth factor activity			skin(3)|ovary(1)|lung(1)|central_nervous_system(1)	6						TTTGGGTAAAGAAAGAAACCT	0.403		NA											28	56					4.88e-14	9.43e-14	1	0
SLCO1C1	53919	broad.mit.edu	37	12	20876088	20876088	+	Missense_Mutation	SNP	C	C	A			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr12:20876088C>A	uc001rej.3	+	10	1441	c.1086C>A	c.(1084-1086)AGC>AGA	p.S362R	SLCO1C1_uc010sii.1_Missense_Mutation_p.S362R|SLCO1C1_uc010sij.1_Missense_Mutation_p.S313R|SLCO1C1_uc009zip.2_Missense_Mutation_p.S196R|SLCO1C1_uc001rei.2_Missense_Mutation_p.S362R|SLCO1C1_uc010sik.1_Missense_Mutation_p.S244R	NM_017435	NP_059131	Q9NYB5	SO1C1_HUMAN	solute carrier organic anion transporter family,	362	Helical; Name=7; (Potential).				sodium-independent organic anion transport	integral to membrane|plasma membrane	thyroid hormone transmembrane transporter activity			ovary(5)|pancreas(1)|skin(1)	7	Esophageal squamous(101;0.149)					TATGTACAAGCACTGTTCAGT	0.378		NA											28	71					4.88e-14	9.43e-14	1	0
SLC38A1	81539	broad.mit.edu	37	12	46592498	46592498	+	Silent	SNP	T	T	C			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr12:46592498T>C	uc001rpa.2	-	14	1290	c.1032A>G	c.(1030-1032)AAA>AAG	p.K344K	SLC38A1_uc001rpb.2_Silent_p.K344K|SLC38A1_uc001rpc.2_Silent_p.K344K|SLC38A1_uc001rpd.2_Silent_p.K344K|SLC38A1_uc001rpe.2_Silent_p.K344K|SLC38A1_uc009zkj.1_Silent_p.K344K	NM_030674	NP_109599	Q9H2H9	S38A1_HUMAN	amino acid transporter system A1	344	Extracellular (Potential).				cellular nitrogen compound metabolic process|neurotransmitter uptake	integral to membrane|plasma membrane	sodium:amino acid symporter activity			ovary(2)|skin(2)|central_nervous_system(1)	5	Lung SC(27;0.137)|Renal(347;0.236)		all cancers(1;0.00805)|OV - Ovarian serous cystadenocarcinoma(5;0.0106)|Epithelial(2;0.0344)			TACTCTGATATTTGTGAAGGA	0.428		NA											16	42					0	0	0	0
SCN8A	6334	broad.mit.edu	37	12	52200796	52200796	+	Silent	SNP	C	C	A			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr12:52200796C>A	uc001ryw.2	+	27	5704	c.5526C>A	c.(5524-5526)ATC>ATA	p.I1842I	uc001rzb.1_5'Flank	NM_014191	NP_055006	Q9UQD0	SCN8A_HUMAN	sodium channel, voltage gated, type VIII, alpha	1842					axon guidance|myelination|peripheral nervous system development	cytoplasmic membrane-bounded vesicle|node of Ranvier	ATP binding|voltage-gated sodium channel activity			ovary(7)	7				BRCA - Breast invasive adenocarcinoma(357;0.181)	Lamotrigine(DB00555)	GGGATCGCATCCACTGCTTGG	0.567		NA											43	110					7.63e-17	1.49e-16	1	0
CALCOCO1	57658	broad.mit.edu	37	12	54106918	54106918	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr12:54106918G>C	uc001sef.2	-	14	2008	c.1864C>G	c.(1864-1866)CCT>GCT	p.P622A	CALCOCO1_uc001see.2_Missense_Mutation_p.P123A|CALCOCO1_uc010som.1_Missense_Mutation_p.P537A|CALCOCO1_uc010son.1_Missense_Mutation_p.P499A|CALCOCO1_uc001seh.2_Missense_Mutation_p.P622A|CALCOCO1_uc009znd.2_Missense_Mutation_p.P621A|CALCOCO1_uc001seg.2_Missense_Mutation_p.P447A	NM_020898	NP_065949	Q9P1Z2	CACO1_HUMAN	coiled-coil transcriptional coactivator isoform	622	C-terminal AD (CTNNB1 binding site) (By similarity).				steroid hormone receptor signaling pathway|transcription, DNA-dependent|Wnt receptor signaling pathway	cytoplasm	armadillo repeat domain binding|beta-catenin binding|ligand-dependent nuclear receptor transcription coactivator activity|protein C-terminus binding|sequence-specific DNA binding|transcription regulatory region DNA binding			ovary(1)	1						CCCAGTTCAGGAAGCAGTAAG	0.577		NA											31	69					0	0	0	0
OR6C70	390327	broad.mit.edu	37	12	55863389	55863389	+	Silent	SNP	G	G	A			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr12:55863389G>A	uc010spn.1	-	1	534	c.534C>T	c.(532-534)GAC>GAT	p.D178D		NM_001005499	NP_001005499	A6NIJ9	O6C70_HUMAN	olfactory receptor, family 6, subfamily C,	178	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						TAAGAGAAATGTCACAAATGA	0.348		NA											32	94					0	0	0	0
LRP1	4035	broad.mit.edu	37	12	57592066	57592066	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr12:57592066C>T	uc001snd.2	+	59	9876	c.9410C>T	c.(9409-9411)ACG>ATG	p.T3137M		NM_002332	NP_002323	Q07954	LRP1_HUMAN	low density lipoprotein-related protein 1	3137	LDL-receptor class B 27.|Extracellular (Potential).				aorta morphogenesis|apoptotic cell clearance|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of Wnt receptor signaling pathway|positive regulation of cholesterol efflux|regulation of actin cytoskeleton organization|regulation of phospholipase A2 activity	coated pit|integral to plasma membrane|nucleus	apolipoprotein E binding|calcium ion binding|lipoprotein transporter activity|protein complex binding|receptor activity			ovary(8)|lung(3)|breast(3)|large_intestine(2)|central_nervous_system(2)|skin(2)|pancreas(2)	22				BRCA - Breast invasive adenocarcinoma(357;0.0103)	Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Becaplermin(DB00102)|Coagulation Factor IX(DB00100)|Tenecteplase(DB00031)	GCCTATCGGACGGTGCTGGTC	0.637		NA											11	32					0	0	0	0
CPSF6	11052	broad.mit.edu	37	12	69656338	69656338	+	Nonstop_Mutation	SNP	A	A	G			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr12:69656338A>G	uc001sut.3	+	9	1765	c.1655A>G	c.(1654-1656)TAG>TGG	p.*552W	CPSF6_uc001suu.3_Nonstop_Mutation_p.*589W|CPSF6_uc010stk.1_Nonstop_Mutation_p.*184W	NM_007007	NP_008938	Q16630	CPSF6_HUMAN	cleavage and polyadenylation specific factor 6,	552					mRNA polyadenylation|protein tetramerization	mRNA cleavage factor complex|paraspeckles|ribonucleoprotein complex	mRNA binding|nucleotide binding|protein binding				0	all_epithelial(5;2.47e-36)|Lung NSC(4;1.1e-32)|all_lung(4;6.26e-31)|Breast(13;1.59e-06)|Esophageal squamous(21;0.187)		Epithelial(6;4.89e-17)|BRCA - Breast invasive adenocarcinoma(5;8.5e-10)|Lung(24;6.04e-05)|LUAD - Lung adenocarcinoma(15;0.00107)|STAD - Stomach adenocarcinoma(21;0.0151)|LUSC - Lung squamous cell carcinoma(43;0.171)|Kidney(9;0.241)			CGTCATCGTTAGAAGGTGGGT	0.313		NA											6	33					0	0	0	0
VEZT	55591	broad.mit.edu	37	12	95694417	95694417	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr12:95694417G>C	uc001tdz.2	+	12	2413	c.2308G>C	c.(2308-2310)GAA>CAA	p.E770Q	VEZT_uc009ztb.1_RNA|VEZT_uc009ztc.1_Missense_Mutation_p.E135Q|VEZT_uc001tdy.2_RNA	NM_017599	NP_060069	Q9HBM0	VEZA_HUMAN	vezatin, adherens junctions transmembrane	770						acrosomal vesicle|adherens junction|integral to membrane|nucleus				ovary(1)	1						ACAAATAATAGAAGAAAATAA	0.383		NA											3	32					0	0	0	0
NAA25	80018	broad.mit.edu	37	12	112518864	112518864	+	Missense_Mutation	SNP	T	T	G			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr12:112518864T>G	uc001ttm.2	-	5	497	c.477A>C	c.(475-477)CAA>CAC	p.Q159H	NAA25_uc001ttn.3_RNA|NAA25_uc009zvz.1_Missense_Mutation_p.Q131H|NAA25_uc009zwa.1_Missense_Mutation_p.Q159H	NM_024953	NP_079229	Q14CX7	NAA25_HUMAN	mitochondrial distribution and morphology 20	159						cytoplasm	protein binding			ovary(1)|breast(1)|pancreas(1)	3						CCATACTCACTTGCATAATTA	0.323		NA											35	157					0	0	0	0
UBC	7316	broad.mit.edu	37	12	125397805	125397805	+	Silent	SNP	G	G	C			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr12:125397805G>C	uc001ugs.3	-	2	961	c.513C>G	c.(511-513)CCC>CCG	p.P171P	UBC_uc001ugr.2_5'Flank|UBC_uc001ugu.1_Silent_p.P171P|UBC_uc001ugt.2_Silent_p.P171P|UBC_uc001ugv.2_Intron|UBC_uc001ugw.2_Silent_p.P19P	NM_021009	NP_066289	P0CG48	UBC_HUMAN	ubiquitin C	171	Ubiquitin-like 3.				activation of MAPK activity|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|anti-apoptosis|apoptosis|cellular membrane organization|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA repair|endosome transport|epidermal growth factor receptor signaling pathway|G1/S transition of mitotic cell cycle|I-kappaB kinase/NF-kappaB cascade|induction of apoptosis by extracellular signals|innate immune response|JNK cascade|M/G1 transition of mitotic cell cycle|mRNA metabolic process|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of type I interferon production|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|S phase of mitotic cell cycle|stress-activated MAPK cascade|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|viral reproduction	cytosol|endocytic vesicle membrane|endosome membrane|nucleoplasm|plasma membrane	protein binding			ovary(2)	2	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;6.17e-05)|Epithelial(86;0.000207)|all cancers(50;0.00308)		TGGTGTCACTGGGCTCCACCT	0.517		NA											4	84					0	0	0	0
LCP1	3936	broad.mit.edu	37	13	46716545	46716545	+	Missense_Mutation	SNP	A	A	C			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr13:46716545A>C	uc001vaz.3	-	13	1510	c.1384T>G	c.(1384-1386)TAC>GAC	p.Y462D	LCP1_uc010ack.2_Missense_Mutation_p.Y31D|LCP1_uc001vay.3_Missense_Mutation_p.Y59D|LCP1_uc001vba.3_Missense_Mutation_p.Y462D	NM_002298	NP_002289	P13796	PLSL_HUMAN	L-plastin	462	Actin-binding 2.|CH 3.				regulation of intracellular protein transport|T cell activation involved in immune response	cell junction|cytosol|ruffle membrane	calcium ion binding			lung(4)|ovary(3)	7		Lung NSC(96;1.27e-05)|Breast(56;8.04e-05)|Prostate(109;0.00217)|Hepatocellular(98;0.0207)|Lung SC(185;0.0262)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;5.39e-05)		TCTACCGCGTAGTTACAATTC	0.373		NA	T	BCL6	NHL 								10	28					0	0	0	0
KLHL1	57626	broad.mit.edu	37	13	70535472	70535472	+	Missense_Mutation	SNP	G	G	A	rs139916031		TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr13:70535472G>A	uc001vip.2	-	3	1579	c.785C>T	c.(784-786)GCT>GTT	p.A262V	KLHL1_uc010thm.1_Missense_Mutation_p.A201V	NM_020866	NP_065917	Q9NR64	KLHL1_HUMAN	kelch-like 1 protein	262	BTB.				actin cytoskeleton organization	cytoplasm|cytoskeleton	actin binding				0		Breast(118;0.000162)		COAD - Colon adenocarcinoma(199;0.000193)|GBM - Glioblastoma multiforme(99;0.000211)		GTCCCAGAGAGCATTGGGGTC	0.388		NA											18	33					0	0	0	0
MYCBP2	23077	broad.mit.edu	37	13	77742684	77742684	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr13:77742684G>C	uc001vkf.2	-	41	5970	c.5879C>G	c.(5878-5880)TCG>TGG	p.S1960W	MYCBP2_uc010aev.2_Missense_Mutation_p.S1364W	NM_015057	NP_055872	O75592	MYCB2_HUMAN	MYC binding protein 2	1960					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ligase activity|protein binding|zinc ion binding			ovary(4)|breast(4)|skin(3)|lung(2)|pancreas(1)	14		Breast(118;0.212)|Acute lymphoblastic leukemia(28;0.22)		GBM - Glioblastoma multiforme(99;0.109)		GCTATCTGTCGACTGATTAGG	0.493		NA											18	72					0	0	0	0
CTAGE5	4253	broad.mit.edu	37	14	39769088	39769088	+	Silent	SNP	A	A	T			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr14:39769088A>T	uc001wvg.3	+	9	1029	c.693A>T	c.(691-693)GTA>GTT	p.V231V	CTAGE5_uc010tqe.1_Silent_p.V193V|CTAGE5_uc001wuz.3_Silent_p.V219V|CTAGE5_uc001wuy.3_Silent_p.V151V|CTAGE5_uc001wvb.3_Silent_p.V202V|CTAGE5_uc001wvc.3_Silent_p.V176V|CTAGE5_uc001wva.3_Silent_p.V202V|CTAGE5_uc001wve.1_Silent_p.V207V|CTAGE5_uc001wvh.3_Silent_p.V231V|CTAGE5_uc001wvf.3_Silent_p.V156V|CTAGE5_uc001wvi.3_Silent_p.V236V|CTAGE5_uc010amz.2_5'UTR|CTAGE5_uc001wvj.3_Silent_p.V202V	NM_005930	NP_005921	O15320	CTGE5_HUMAN	CTAGE family, member 5 isoform 1	231	Potential.						enzyme activator activity|protein binding				0	Hepatocellular(127;0.213)		LUAD - Lung adenocarcinoma(48;0.000565)|Lung(238;0.000711)	GBM - Glioblastoma multiforme(112;0.0475)		AAGCTGAAGTATGGAAAGAAC	0.318		NA											8	75					0	0	0	0
PRKCH	5583	broad.mit.edu	37	14	61997130	61997130	+	Silent	SNP	C	C	A			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr14:61997130C>A	uc001xfn.2	+	12	1883	c.1578C>A	c.(1576-1578)CTC>CTA	p.L526L	PRKCH_uc010tsa.1_Silent_p.L365L|PRKCH_uc010tsb.1_Silent_p.L94L	NM_006255	NP_006246	P24723	KPCL_HUMAN	protein kinase C, eta	526	Protein kinase.				intracellular signal transduction|platelet activation	cytosol|plasma membrane	ATP binding|enzyme binding|metal ion binding|protein kinase C activity			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|lung(1)|large_intestine(1)|skin(1)	6				OV - Ovarian serous cystadenocarcinoma(108;0.045)|BRCA - Breast invasive adenocarcinoma(234;0.0906)|KIRC - Kidney renal clear cell carcinoma(182;0.182)		CACAGATCCTCCAGGAAATGC	0.483		NA											30	138					3.99e-17	7.85e-17	1	0
RGS6	9628	broad.mit.edu	37	14	72925015	72925015	+	Missense_Mutation	SNP	A	A	C			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr14:72925015A>C	uc001xna.3	+	5	795	c.272A>C	c.(271-273)CAG>CCG	p.Q91P	RGS6_uc010ttn.1_Missense_Mutation_p.Q91P|RGS6_uc001xmx.3_Missense_Mutation_p.Q91P|RGS6_uc010tto.1_RNA|RGS6_uc001xmy.3_Missense_Mutation_p.Q91P|RGS6_uc010ttp.1_Missense_Mutation_p.Q22P|RGS6_uc001xmz.1_5'Flank|RGS6_uc010arg.2_RNA	NM_004296	NP_004287	P49758	RGS6_HUMAN	regulator of G-protein signalling 6	91	DEP.				G-protein coupled receptor protein signaling pathway|intracellular signal transduction|negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway	cytoplasm|heterotrimeric G-protein complex	GTPase activator activity|signal transducer activity			upper_aerodigestive_tract(1)|lung(1)|skin(1)	3				all cancers(60;0.00309)|BRCA - Breast invasive adenocarcinoma(234;0.0281)|STAD - Stomach adenocarcinoma(64;0.0302)|OV - Ovarian serous cystadenocarcinoma(108;0.0476)		ATCGCTGCCCAGGGCTACATC	0.458		NA											26	53					0	0	0	0
TECPR2	9895	broad.mit.edu	37	14	102931608	102931608	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr14:102931608G>C	uc001ylw.1	+	17	3919	c.3771G>C	c.(3769-3771)ATG>ATC	p.M1257I	TECPR2_uc010awl.2_Missense_Mutation_p.M1257I|TECPR2_uc010txx.1_Missense_Mutation_p.M420I	NM_014844	NP_055659	O15040	TCPR2_HUMAN	tectonin beta-propeller repeat containing 2	1257	TECPR 4.						protein binding			lung(1)|central_nervous_system(1)|skin(1)	3						CCTGGATAATGATTGAGCCAC	0.502		NA											13	45					0	0	0	0
RYR3	6263	broad.mit.edu	37	15	33955093	33955093	+	Nonsense_Mutation	SNP	G	G	T			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr15:33955093G>T	uc001zhi.2	+	35	5432	c.5362G>T	c.(5362-5364)GAG>TAG	p.E1788*	RYR3_uc010bar.2_Nonsense_Mutation_p.E1788*	NM_001036	NP_001027	Q15413	RYR3_HUMAN	ryanodine receptor 3	1788	4 X approximate repeats.|Cytoplasmic (By similarity).				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(5)|central_nervous_system(4)|lung(1)	10		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		GGCCGGCAAGGAGGCTCCTGT	0.562		NA											29	179					1.31e-18	2.59e-18	1	0
HERC1	8925	broad.mit.edu	37	15	63904544	63904544	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr15:63904544C>T	uc002amp.2	-	77	14454	c.14306G>A	c.(14305-14307)CGG>CAG	p.R4769Q	HERC1_uc002amo.2_5'Flank	NM_003922	NP_003913	Q15751	HERC1_HUMAN	hect domain and RCC1-like domain 1	4769	HECT.				protein modification process|transport	cytosol|Golgi apparatus|membrane	acid-amino acid ligase activity|ARF guanyl-nucleotide exchange factor activity			ovary(6)|breast(6)|lung(5)|central_nervous_system(2)	19						GAAAAGCACCCGCTCCTCATT	0.493		NA											6	44					0	0	0	0
ISL2	64843	broad.mit.edu	37	15	76629267	76629267	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr15:76629267G>A	uc002bbw.1	+	1	121	c.43G>A	c.(43-45)GGT>AGT	p.G15S		NM_145805	NP_665804	Q96A47	ISL2_HUMAN	ISL LIM homeobox 2	15						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0						GGGTGCTATGGGTGATCATTC	0.443		NA											52	330					0	0	0	0
SRRM2	23524	broad.mit.edu	37	16	2817671	2817671	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr16:2817671C>G	uc002crk.2	+	11	7691	c.7142C>G	c.(7141-7143)ACC>AGC	p.T2381S	SRRM2_uc002crj.1_Missense_Mutation_p.T2285S|SRRM2_uc002crl.1_Missense_Mutation_p.T2381S|SRRM2_uc010bsu.1_Missense_Mutation_p.T2285S	NM_016333	NP_057417	Q9UQ35	SRRM2_HUMAN	splicing coactivator subunit SRm300	2381	Ser-rich.					Cajal body|catalytic step 2 spliceosome|nuclear speck	C2H2 zinc finger domain binding|protein N-terminus binding|RNA binding			ovary(1)|pancreas(1)|central_nervous_system(1)|skin(1)	4						GCAAACCTCACCAGCCCCAGG	0.632		NA											34	87					0	0	0	0
C16orf88	400506	broad.mit.edu	37	16	19718478	19718478	+	Silent	SNP	G	G	C			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr16:19718478G>C	uc002dgq.2	-	5	1146	c.1131C>G	c.(1129-1131)CTC>CTG	p.L377L		NM_001012991	NP_001013009	Q1ED39	CP088_HUMAN	hypothetical protein LOC400506	377	Interaction with ZFP106 (By similarity).					nucleolus					0						CCATAAGTCTGAGAAATTTCA	0.532		NA											25	61					0	0	0	0
XPO6	23214	broad.mit.edu	37	16	28167615	28167615	+	Missense_Mutation	SNP	T	T	C			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr16:28167615T>C	uc002dpa.1	-	7	1378	c.877A>G	c.(877-879)AAC>GAC	p.N293D	XPO6_uc002dpb.1_Missense_Mutation_p.N279D|XPO6_uc010vcp.1_Missense_Mutation_p.N293D	NM_015171	NP_055986	Q96QU8	XPO6_HUMAN	exportin 6	293					protein export from nucleus		protein binding|protein transporter activity			ovary(1)|skin(1)	2						CTGCTGCCGTTAACTGACGCC	0.577		NA											29	67					0	0	0	0
APOB48R	55911	broad.mit.edu	37	16	28508717	28508717	+	Silent	SNP	G	G	C			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr16:28508717G>C	uc002dqb.1	+	3	2338	c.2328G>C	c.(2326-2328)GTG>GTC	p.V776V	uc010vct.1_Intron|APOB48R_uc010byg.1_Silent_p.V314V	NM_018690	NP_061160	Q0VD83	APOBR_HUMAN	apolipoprotein B48 receptor	776	Glu-rich.				cholesterol metabolic process|lipid transport	chylomicron|low-density lipoprotein particle|plasma membrane|very-low-density lipoprotein particle					0						TGGAAGGGGTGCTTGGGCAAG	0.587		NA											11	24					0	0	0	0
SIAH1	6477	broad.mit.edu	37	16	48395697	48395697	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr16:48395697G>A	uc002efo.1	-	2	760	c.643C>T	c.(643-645)CGC>TGC	p.R215C	uc002efk.1_RNA|SIAH1_uc002efl.2_RNA|SIAH1_uc002efn.1_Missense_Mutation_p.R246C	NM_003031	NP_003022	Q8IUQ4	SIAH1_HUMAN	seven in absentia homolog 1 isoform a	215	SBD.			TR->AA: In mutant D; does not impair its ability to interact with CACYBP and degrade CTNNB1 and PML; when associated with A-124; A-231 and A-232.	axon guidance|cell cycle|neuron apoptosis|proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|spermatogenesis	beta-catenin destruction complex|cytosol|nucleus	protein C-terminus binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)	1		all_cancers(37;0.157)|all_lung(18;0.11)|Breast(268;0.238)				GCTTGCTTGCGTGTTCCTATC	0.443		NA											14	66					0	0	0	0
CX3CL1	6376	broad.mit.edu	37	16	57416529	57416529	+	Missense_Mutation	SNP	T	T	A			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr16:57416529T>A	uc002eli.2	+	3	846	c.779T>A	c.(778-780)CTG>CAG	p.L260Q		NM_002996	NP_002987	P78423	X3CL1_HUMAN	chemokine (C-X3-C motif) ligand 1 precursor	260	Mucin-like stalk.|Extracellular (Potential).				cell adhesion|cytokine-mediated signaling pathway|defense response|immune response|leukocyte adhesive activation|positive regulation of calcium-independent cell-cell adhesion|positive regulation of inflammatory response	cell surface|extracellular space|integral to membrane|plasma membrane	chemokine activity				0						GAGAACTCTCTGGAGCGGGAG	0.667		NA											22	44					0	0	0	0
COG4	25839	broad.mit.edu	37	16	70551611	70551611	+	Missense_Mutation	SNP	T	T	C			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr16:70551611T>C	uc002ezc.2	-	3	298	c.287A>G	c.(286-288)AAG>AGG	p.K96R	COG4_uc010cfu.2_RNA|COG4_uc002ezd.2_Missense_Mutation_p.K96R|COG4_uc002eze.2_5'UTR	NM_015386	NP_056201	Q9H9E3	COG4_HUMAN	component of oligomeric golgi complex 4	92	Interacts with STX5.				Golgi organization|Golgi vesicle prefusion complex stabilization|protein transport|retrograde vesicle-mediated transport, Golgi to ER	Golgi membrane|Golgi transport complex	protein binding				0		Ovarian(137;0.0694)				AGCCAGCTGCTTTGCATCTCC	0.443		NA											32	62					0	0	0	0
FBXO31	79791	broad.mit.edu	37	16	87365007	87365007	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr16:87365007G>C	uc002fjw.2	-	9	1551	c.1507C>G	c.(1507-1509)CTG>GTG	p.L503V	FBXO31_uc010vot.1_Missense_Mutation_p.L331V|FBXO31_uc002fjv.2_Missense_Mutation_p.L395V	NM_024735	NP_079011	Q5XUX0	FBX31_HUMAN	F-box protein 31	503					cell cycle|cyclin catabolic process|mitotic cell cycle G1/S transition DNA damage checkpoint|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	SCF ubiquitin ligase complex	cyclin binding			lung(1)	1				BRCA - Breast invasive adenocarcinoma(80;0.0272)		AAGGATTTCAGCTCCAGCCAG	0.622		NA											13	24					0	0	0	0
ATP1B2	482	broad.mit.edu	37	17	7557506	7557506	+	Silent	SNP	C	C	T			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr17:7557506C>T	uc002gif.1	+	4	1066	c.483C>T	c.(481-483)TCC>TCT	p.S161S		NM_001678	NP_001669	P14415	AT1B2_HUMAN	Na+/K+ -ATPase beta 2 subunit	161	Extracellular (Potential).				ATP biosynthetic process|blood coagulation|leukocyte migration	integral to membrane|plasma membrane	protein binding|sodium:potassium-exchanging ATPase activity	p.0?(2)|p.?(1)		central_nervous_system(1)|pancreas(1)	2		all_cancers(10;0.000178)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;2.55e-06)|READ - Rectum adenocarcinoma(115;0.168)		GCAACTGCTCCGGCATTGGGG	0.562		NA											149	122					0	0	0	0
TNFRSF13B	23495	broad.mit.edu	37	17	16875383	16875383	+	Missense_Mutation	SNP	C	C	A			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr17:16875383C>A	uc002gqs.1	-	1	20	c.7G>T	c.(7-9)GGC>TGC	p.G3C	TNFRSF13B_uc010vwt.1_RNA|TNFRSF13B_uc002gqt.1_Missense_Mutation_p.G3C|TNFRSF13B_uc010vwu.1_Missense_Mutation_p.G3C	NM_012452	NP_036584	O14836	TR13B_HUMAN	tumor necrosis factor receptor 13B	3	Extracellular (Potential).				cell surface receptor linked signaling pathway	integral to plasma membrane	protein binding|receptor activity			kidney(2)	2						CGGCCCAGGCCACTCATTACT	0.582		NA							IgA_Deficiency_Selective				13	43					9.31e-06	1.7e-05	1	0
NFE2L1	4779	broad.mit.edu	37	17	46128746	46128746	+	Missense_Mutation	SNP	C	C	A			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr17:46128746C>A	uc002imz.3	+	2	917	c.266C>A	c.(265-267)GCC>GAC	p.A89D	NFE2L1_uc002ina.3_Missense_Mutation_p.A89D|NFE2L1_uc002inb.3_Missense_Mutation_p.A89D|NFE2L1_uc002inc.1_Missense_Mutation_p.A89D	NM_003204	NP_003195	Q14494	NF2L1_HUMAN	nuclear factor erythroid 2-like 1	89					anatomical structure morphogenesis|heme biosynthetic process|inflammatory response|transcription from RNA polymerase II promoter	nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription cofactor activity			skin(1)	1						CAGGTGAGGGCCCTGGACAGG	0.582		NA											25	94					3.08e-08	5.83e-08	1	0
BAHCC1	57597	broad.mit.edu	37	17	79410355	79410355	+	Silent	SNP	C	C	T			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr17:79410355C>T	uc002kaf.2	+	3	1980	c.1980C>T	c.(1978-1980)GCC>GCT	p.A660A	BAHCC1_uc002kae.2_5'Flank	NM_001080519	NP_001073988	Q9P281	BAHC1_HUMAN	BAH domain and coiled-coil containing 1	660							DNA binding			ovary(1)	1	all_neural(118;0.0804)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0224)|OV - Ovarian serous cystadenocarcinoma(97;0.116)			GCCTCAAGGCCAGCTGCATCC	0.642		NA											6	14					0	0	0	0
CDH7	1005	broad.mit.edu	37	18	63547834	63547834	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr18:63547834C>T	uc002ljz.2	+	12	2387	c.2062C>T	c.(2062-2064)CCA>TCA	p.P688S	CDH7_uc002lkb.2_Missense_Mutation_p.P688S	NM_033646	NP_387450	Q9ULB5	CADH7_HUMAN	cadherin 7, type 2 preproprotein	688	Cytoplasmic (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)|pancreas(1)|skin(1)	4		Esophageal squamous(42;0.129)				GGATGTGACTCCAGAAATTCA	0.478		NA											13	42					0	0	0	0
DSEL	92126	broad.mit.edu	37	18	65180979	65180979	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr18:65180979C>G	uc002lke.1	-	2	2121	c.897G>C	c.(895-897)CAG>CAC	p.Q299H		NM_032160	NP_115536	Q8IZU8	DSEL_HUMAN	dermatan sulfate epimerase-like	289						integral to membrane	isomerase activity|sulfotransferase activity			ovary(3)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	6		Esophageal squamous(42;0.129)				GAAAAACATACTGTGTGACGG	0.388		NA											14	69					0	0	0	0
FBN3	84467	broad.mit.edu	37	19	8131097	8131097	+	Silent	SNP	C	C	T			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr19:8131097C>T	uc002mjf.2	-	63	8157	c.8136G>A	c.(8134-8136)CTG>CTA	p.L2712L	FBN3_uc002mje.2_Silent_p.L508L	NM_032447	NP_115823	Q75N90	FBN3_HUMAN	fibrillin 3 precursor	2712						proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			ovary(6)|skin(3)|pancreas(1)|central_nervous_system(1)	11						GTGAGAGGTTCAGGCCCAAGG	0.662		NA											8	15					0	0	0	0
FBN3	84467	broad.mit.edu	37	19	8188397	8188397	+	Silent	SNP	G	G	A	rs145240162	byFrequency	TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr19:8188397G>A	uc002mjf.2	-	23	3054	c.3033C>T	c.(3031-3033)TGC>TGT	p.C1011C		NM_032447	NP_115823	Q75N90	FBN3_HUMAN	fibrillin 3 precursor	1011	EGF-like 12; calcium-binding.					proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			ovary(6)|skin(3)|pancreas(1)|central_nervous_system(1)	11						CCGCACAGGCGCAGTGGAAGC	0.597		NA											16	26					0	0	0	0
OR2Z1	284383	broad.mit.edu	37	19	8842012	8842012	+	Missense_Mutation	SNP	A	A	C			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr19:8842012A>C	uc010xkg.1	+	1	622	c.622A>C	c.(622-624)ATG>CTG	p.M208L		NM_001004699	NP_001004699	Q8NG97	OR2Z1_HUMAN	olfactory receptor, family 2, subfamily Z,	208	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|skin(1)	2						GCTGATCCTAATGCTCCCTCT	0.582		NA											34	51					0	0	0	0
MUC16	94025	broad.mit.edu	37	19	9049680	9049680	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr19:9049680C>G	uc002mkp.2	-	5	32155	c.31951G>C	c.(31951-31953)GCA>CCA	p.A10651P		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	10653	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GGGGTCAGTGCATCTAGTTCA	0.473		NA											14	63					0	0	0	0
SLC44A2	57153	broad.mit.edu	37	19	10753954	10753954	+	Splice_Site	SNP	G	G	A			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr19:10753954G>A	uc002mpf.2	+	22	2154	c.2015_splice	c.e22-1	p.L672_splice	SLC44A2_uc002mpe.3_Splice_Site_p.L670_splice|SLC44A2_uc002mpg.1_3'UTR|SLC44A2_uc002mph.2_Splice_Site_p.L221_splice|SLC44A2_uc002mpi.2_Splice_Site	NM_020428	NP_065161	Q8IWA5	CTL2_HUMAN	solute carrier family 44, member 2 isoform 1						positive regulation of I-kappaB kinase/NF-kappaB cascade	integral to membrane|plasma membrane	choline transmembrane transporter activity|signal transducer activity			ovary(1)	1			Epithelial(33;8.7e-06)|all cancers(31;2.77e-05)		Choline(DB00122)	TCTCTCCACAGTGGAGGACCT	0.592		NA											7	6					0	0	0	0
ZNF844	284391	broad.mit.edu	37	19	12186456	12186456	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr19:12186456G>A	uc002mtb.2	+	4	664	c.521G>A	c.(520-522)TGT>TAT	p.C174Y	ZNF844_uc010dym.1_Missense_Mutation_p.C17Y	NM_001136501	NP_001129973	Q08AG5	ZN844_HUMAN	zinc finger protein 844	174	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						TGTAAAGAATGTGGAAAAACC	0.383		NA											12	20					0	0	0	0
ZNF564	163050	broad.mit.edu	37	19	12639154	12639154	+	Missense_Mutation	SNP	A	A	C			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr19:12639154A>C	uc002mty.2	-	3	365	c.155T>G	c.(154-156)ATT>AGT	p.I52S	ZNF709_uc002mtx.3_Intron	NM_144976	NP_659413	Q8TBZ8	ZN564_HUMAN	zinc finger protein 564	52	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						CCAATCTTCAATGCTCTGGTC	0.299		NA											5	32					0	0	0	0
CD97	976	broad.mit.edu	37	19	14513676	14513676	+	Splice_Site	SNP	T	T	C			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr19:14513676T>C	uc002myl.2	+	12	1572	c.1449_splice	c.e12+2	p.K483_splice	CD97_uc002mym.2_Splice_Site_p.K434_splice|CD97_uc002myn.2_Splice_Site_p.K390_splice	NM_078481	NP_510966	P48960	CD97_HUMAN	CD97 antigen isoform 1 precursor						cell adhesion|cell-cell signaling|cellular component movement|immune response|inflammatory response|neuropeptide signaling pathway	extracellular space|integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			ovary(3)|breast(1)	4						CCTGCCAAGGTCTCTGCTCAC	0.368		NA											18	45					0	0	0	0
CYP4F2	8529	broad.mit.edu	37	19	15989681	15989681	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr19:15989681C>T	uc002nbs.1	-	13	1513	c.1463G>A	c.(1462-1464)CGC>CAC	p.R488H	CYP4F2_uc010xot.1_Missense_Mutation_p.R339H	NM_001082	NP_001073	P78329	CP4F2_HUMAN	cytochrome P450, family 4, subfamily F,	488					leukotriene metabolic process|long-chain fatty acid metabolic process|very long-chain fatty acid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	alkane 1-monooxygenase activity|electron carrier activity|heme binding|leukotriene-B4 20-monooxygenase activity|oxygen binding|protein binding			ovary(1)|skin(1)	2						GACGCGGAAGCGCAGCAGCGT	0.677		NA											9	68					0	0	0	0
KCNN1	3780	broad.mit.edu	37	19	18084991	18084991	+	Silent	SNP	G	G	C			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr19:18084991G>C	uc002nht.2	+	3	604	c.294G>C	c.(292-294)GCG>GCC	p.A98A	KCNN1_uc010xqa.1_Silent_p.A98A	NM_002248	NP_002239	Q92952	KCNN1_HUMAN	potassium intermediate/small conductance	98					synaptic transmission	voltage-gated potassium channel complex	calmodulin binding|small conductance calcium-activated potassium channel activity				0						ACCGGCGGGCGCTCTTCGAGA	0.627		NA											4	17					0	0	0	0
IL12RB1	3594	broad.mit.edu	37	19	18191667	18191667	+	Silent	SNP	C	C	T			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr19:18191667C>T	uc002nhw.1	-	4	448	c.384G>A	c.(382-384)GAG>GAA	p.E128E	IL12RB1_uc010xqb.1_Silent_p.E128E|IL12RB1_uc002nhx.1_Silent_p.E168E|IL12RB1_uc002nhy.2_Silent_p.E128E	NM_005535	NP_005526	P42701	I12R1_HUMAN	interleukin 12 receptor, beta 1 isoform 1	128	Extracellular (Potential).|Fibronectin type-III 1.				cellular response to interferon-gamma|interleukin-12-mediated signaling pathway|positive regulation of activated T cell proliferation|positive regulation of defense response to virus by host|positive regulation of interferon-gamma production|positive regulation of memory T cell differentiation|positive regulation of T cell mediated cytotoxicity|positive regulation of T-helper 1 type immune response|positive regulation of T-helper 17 cell lineage commitment|positive regulation of T-helper 17 type immune response	interleukin-12 receptor complex|interleukin-23 receptor complex	cytokine receptor activity			pancreas(1)	1						GCAGGGTCACCTCAGGAGACT	0.582		NA											14	76					0	0	0	0
ZNF45	7596	broad.mit.edu	37	19	44418581	44418582	+	Missense_Mutation	DNP	GC	GC	AT			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr19:44418581_44418582GC>AT	uc002oxu.1	-	4	1105_1106	c.1006_1007GC>AT	c.(1006-1008)GCA>ATA	p.A336I	ZNF45_uc002oxw.1_Missense_Mutation_p.A336I|ZNF45_uc002oxv.1_Missense_Mutation_p.A336I	NM_003425	NP_003416	Q02386	ZNF45_HUMAN	zinc finger protein 45	336	C2H2-type 7.				multicellular organismal development	nucleoplasm	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1						CTTGCCACATGCATTGCATTTG	0.455		NA											22	48					0	0	0	0
CEACAM20	125931	broad.mit.edu	37	19	45016078	45016078	+	Missense_Mutation	SNP	T	T	A			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr19:45016078T>A	uc010ejn.1	-	10	1588	c.1572A>T	c.(1570-1572)GAA>GAT	p.E524D	CEACAM20_uc010ejo.1_Missense_Mutation_p.E524D|CEACAM20_uc010ejp.1_Missense_Mutation_p.E431D|CEACAM20_uc010ejq.1_Missense_Mutation_p.E431D	NM_001102597	NP_001096067	Q6UY09	CEA20_HUMAN	carcinoembryonic antigen-related cell adhesion	524	Cytoplasmic (Potential).					integral to membrane				large_intestine(2)	2		Prostate(69;0.0352)				CACTCACCAGTTCGACTCTGA	0.488		NA											3	10					0	0	0	0
ZNF616	90317	broad.mit.edu	37	19	52618924	52618924	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr19:52618924C>T	uc002pym.2	-	4	1776	c.1493G>A	c.(1492-1494)TGT>TAT	p.C498Y	ZNF616_uc002pyn.2_RNA	NM_178523	NP_848618	Q08AN1	ZN616_HUMAN	zinc finger protein 616	498	C2H2-type 12.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				GBM - Glioblastoma multiforme(134;0.00392)|OV - Ovarian serous cystadenocarcinoma(262;0.0189)		GACCTTGCCACATTCATTGCA	0.403		NA											13	97					0	0	0	0
NLRP7	199713	broad.mit.edu	37	19	55441964	55441964	+	Missense_Mutation	SNP	G	G	T			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr19:55441964G>T	uc002qih.3	-	9	2789	c.2713C>A	c.(2713-2715)CTC>ATC	p.L905I	NLRP7_uc002qig.3_Missense_Mutation_p.L877I|NLRP7_uc002qii.3_Missense_Mutation_p.L905I|NLRP7_uc010esk.2_Missense_Mutation_p.L905I|NLRP7_uc010esl.2_Missense_Mutation_p.L933I	NM_206828	NP_996611	Q8WX94	NALP7_HUMAN	NACHT, leucine rich repeat and PYD containing 7	905	LRR 8.						ATP binding			large_intestine(1)|breast(1)|central_nervous_system(1)	3				GBM - Glioblastoma multiforme(193;0.0325)		AGGTTTGTGAGGCTGCAGGCT	0.463		NA											50	66					3.32e-32	6.59e-32	1	0
ZNF470	388566	broad.mit.edu	37	19	57089845	57089845	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr19:57089845G>A	uc002qnl.3	+	6	2724	c.2048G>A	c.(2047-2049)GGA>GAA	p.G683E	ZNF470_uc010etn.2_Intron	NM_001001668	NP_001001668	Q6ECI4	ZN470_HUMAN	zinc finger protein 470	683	C2H2-type 17.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|pancreas(1)	2		Colorectal(82;5.46e-05)|Ovarian(87;0.0822)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0294)		AAAGAATGTGGAAAAGCCTTC	0.343		NA											11	47					0	0	0	0
ZNF547	284306	broad.mit.edu	37	19	57879930	57879930	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr19:57879930G>A	uc002qol.2	+	2	200	c.7G>A	c.(7-9)GAA>AAA	p.E3K	ZNF547_uc010ygx.1_Missense_Mutation_p.E3K	NM_173631	NP_775902	Q8IVP9	ZN547_HUMAN	zinc finger protein 547	3					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|central_nervous_system(1)	2		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0694)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		GGCGATGGCAGAAATGAACCC	0.493		NA											7	56					0	0	0	0
A1BG	1	broad.mit.edu	37	19	58862944	58862944	+	Missense_Mutation	SNP	G	G	T	rs117988784	by1000genomes	TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr19:58862944G>T	uc002qsd.3	-	5	785	c.723C>A	c.(721-723)TTC>TTA	p.F241L	NCRNA00181_uc002qse.2_Intron|A1BG_uc002qsf.1_RNA|NCRNA00181_uc002qsg.2_5'Flank	NM_130786	NP_570602	P04217	A1BG_HUMAN	alpha 1B-glycoprotein precursor	241	Ig-like V-type 3.					extracellular region					0		all_cancers(17;3.04e-16)|all_epithelial(17;7.77e-12)|Lung NSC(17;3.25e-05)|Colorectal(82;5.46e-05)|all_lung(17;0.000129)|all_neural(62;0.0182)|Ovarian(87;0.0443)|Breast(46;0.0889)|Renal(17;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0269)		GCCGTAGCTGGAAGTCCACTC	0.637		NA											15	23					1.63e-17	3.21e-17	1	0
SLC27A5	10998	broad.mit.edu	37	19	59011917	59011917	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr19:59011917G>A	uc002qtc.2	-	5	1449	c.1339C>T	c.(1339-1341)CGC>TGC	p.R447C	SLC27A5_uc002qtb.2_5'Flank	NM_012254	NP_036386	Q9Y2P5	S27A5_HUMAN	solute carrier family 27 (fatty acid	447	Cytoplasmic (Probable).				bile acid and bile salt transport|bile acid biosynthetic process|very long-chain fatty acid metabolic process	endoplasmic reticulum membrane|integral to membrane	ATP binding|cholate-CoA ligase activity|long-chain fatty acid-CoA ligase activity				0		all_cancers(17;4.4e-22)|all_epithelial(17;2.15e-16)|Lung NSC(17;1.24e-06)|all_lung(17;5.41e-06)|Colorectal(82;3.46e-05)|Renal(17;0.00179)|all_neural(62;0.00607)|Ovarian(87;0.0443)|Breast(46;0.0928)|Medulloblastoma(540;0.184)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0168)|Lung(386;0.181)		GCCCCGCAGCGCCCCACATAG	0.602		NA											10	32					0	0	0	0
LTBP1	4052	broad.mit.edu	37	2	33412051	33412051	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr2:33412051C>T	uc002ros.2	+	6	1330	c.1330C>T	c.(1330-1332)CAG>TAG	p.Q444*	LTBP1_uc002rot.2_Nonsense_Mutation_p.Q118*|LTBP1_uc002rou.2_Nonsense_Mutation_p.Q118*|LTBP1_uc002rov.2_Nonsense_Mutation_p.Q118*|LTBP1_uc010ymz.1_Nonsense_Mutation_p.Q118*|LTBP1_uc010yna.1_Nonsense_Mutation_p.Q118*	NM_206943	NP_996826	Q14766	LTBP1_HUMAN	latent transforming growth factor beta binding	444					negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta	proteinaceous extracellular matrix	calcium ion binding|growth factor binding|transforming growth factor beta receptor activity			ovary(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|central_nervous_system(1)	8	all_hematologic(175;0.115)	Medulloblastoma(90;0.215)				TAAACTTTATCAGCATTCCCA	0.512		NA											18	50					0	0	0	0
CTNNA2	1496	broad.mit.edu	37	2	80097053	80097053	+	Missense_Mutation	SNP	A	A	G			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr2:80097053A>G	uc010ysh.1	+	4	582	c.577A>G	c.(577-579)AGA>GGA	p.R193G	CTNNA2_uc010yse.1_Missense_Mutation_p.R193G|CTNNA2_uc010ysf.1_Missense_Mutation_p.R193G|CTNNA2_uc010ysg.1_Missense_Mutation_p.R193G	NM_004389	NP_004380	P26232	CTNA2_HUMAN	catenin, alpha 2 isoform 1	193					axonogenesis|brain morphogenesis|cell-cell adhesion|dendrite morphogenesis|muscle cell differentiation|positive regulation of muscle cell differentiation|prepulse inhibition|radial glia guided migration of Purkinje cell|regulation of synapse structural plasticity	actin cytoskeleton|axon|cytosol	cadherin binding|structural constituent of cytoskeleton			pancreas(4)|lung(3)|breast(1)|skin(1)	9						AGCAGCAAGAAGACAACAGGT	0.403		NA											16	68					0	0	0	0
NEB	4703	broad.mit.edu	37	2	152586143	152586143	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr2:152586143C>T	uc010fnx.2	-	4	255	c.64G>A	c.(64-66)GAG>AAG	p.E22K		NM_004543	NP_004534	P20929	NEBU_HUMAN	nebulin isoform 3	22					muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			ovary(8)|large_intestine(5)|breast(3)|central_nervous_system(2)|skin(1)|pancreas(1)	20				BRCA - Breast invasive adenocarcinoma(221;0.219)		CCCGGCACCTCTTCGTAAACC	0.493		NA											42	65					0	0	0	0
SCN9A	6335	broad.mit.edu	37	2	167060716	167060716	+	Missense_Mutation	SNP	A	A	G			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr2:167060716A>G	uc010fpl.2	-	26	4831	c.4490T>C	c.(4489-4491)ATA>ACA	p.I1497T	uc002udp.2_Intron	NM_002977	NP_002968	Q15858	SCN9A_HUMAN	sodium channel, voltage-gated, type IX, alpha	1508						voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|central_nervous_system(5)|skin(2)	13					Lamotrigine(DB00555)|Lidocaine(DB00281)	TAGGTCAAATATACATCCTTG	0.318		NA											17	24					0	0	0	0
TTN	7273	broad.mit.edu	37	2	179528604	179528604	+	Silent	SNP	G	G	A			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr2:179528604G>A	uc010zfk.1	-	15	1376	c.828C>T	c.(826-828)ATC>ATT	p.I276I	TTN_uc010zfg.1_Intron|TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Intron|TTN_uc010fre.1_Intron			Q8WZ42	TITIN_HUMAN	SubName: Full=Titin; Flags: Fragment;	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCTCTTCGCGGATAACCTCTT	0.423		NA											84	202					0	0	0	0
COL5A2	1290	broad.mit.edu	37	2	189906418	189906418	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr2:189906418C>T	uc002uqk.2	-	50	3802	c.3527G>A	c.(3526-3528)GGT>GAT	p.G1176D	COL5A2_uc010frx.2_Missense_Mutation_p.G752D	NM_000393	NP_000384	P05997	CO5A2_HUMAN	alpha 2 type V collagen preproprotein	1176					axon guidance|collagen fibril organization|eye morphogenesis|skin development	collagen type V	extracellular matrix structural constituent			ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.127)			GCCTGGAGGACCCTGCAAGAA	0.448		NA											29	74					0	0	0	0
DNAH7	56171	broad.mit.edu	37	2	196718132	196718132	+	Missense_Mutation	SNP	C	C	A			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr2:196718132C>A	uc002utj.3	-	46	8817	c.8716G>T	c.(8716-8718)GGG>TGG	p.G2906W		NM_018897	NP_061720	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	2906					ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			skin(10)|ovary(2)	12						AGGATATCCCCAGTCAAGTTG	0.507		NA											22	23					1.28e-07	2.41e-07	1	0
MDH1B	130752	broad.mit.edu	37	2	207605810	207605810	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr2:207605810G>A	uc002vbs.2	-	10	1482	c.1427C>T	c.(1426-1428)CCT>CTT	p.P476L	MDH1B_uc010ziw.1_RNA|MDH1B_uc010fui.2_Missense_Mutation_p.P476L|MDH1B_uc010fuj.2_Missense_Mutation_p.P378L|MDH1B_uc002vbt.2_RNA	NM_001039845	NP_001034934	Q5I0G3	MDH1B_HUMAN	malate dehydrogenase 1B, NAD (soluble)	476					carbohydrate metabolic process|malate metabolic process|tricarboxylic acid cycle		binding|malate dehydrogenase activity			ovary(3)|kidney(1)	4				LUSC - Lung squamous cell carcinoma(261;0.0763)|Epithelial(149;0.131)|Lung(261;0.145)		TTCTTCATCAGGGACCAGATC	0.333		NA											20	25					0	0	0	0
C20orf54	113278	broad.mit.edu	37	20	745904	745904	+	Missense_Mutation	SNP	A	A	G			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr20:745904A>G	uc002wed.3	-	2	854	c.515T>C	c.(514-516)ATA>ACA	p.I172T	C20orf54_uc002wee.2_Missense_Mutation_p.I172T	NM_033409	NP_212134	Q9NQ40	RFT2_HUMAN	hypothetical protein LOC113278 precursor	172					sensory perception of sound	integral to plasma membrane	riboflavin transporter activity			ovary(2)	2						GCTGTCTGATATCTCAGTGAC	0.577		NA											15	73					0	0	0	0
ITPA	3704	broad.mit.edu	37	20	3202541	3202541	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr20:3202541C>T	uc002wid.2	+	7	608	c.466C>T	c.(466-468)CAG>TAG	p.Q156*	ITPA_uc002wie.2_Nonsense_Mutation_p.Q139*|ITPA_uc002wif.2_RNA	NM_033453	NP_258412	Q9BY32	ITPA_HUMAN	inosine triphosphatase isoform a	156					nucleotide metabolic process	cytoplasm	metal ion binding|nucleoside-triphosphate diphosphatase activity|nucleotide binding			ovary(1)	1						CCCCTGCTTTCAGCCTGATGG	0.617		NA											9	41					0	0	0	0
PROCR	10544	broad.mit.edu	37	20	33764086	33764086	+	Silent	SNP	G	G	A			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr20:33764086G>A	uc002xbt.2	+	3	622	c.438G>A	c.(436-438)GAG>GAA	p.E146E	EDEM2_uc010zuv.1_Intron|PROCR_uc010zuw.1_Silent_p.E183E	NM_006404	NP_006395	Q9UNN8	EPCR_HUMAN	endothelial protein C receptor precursor	146	Extracellular (Potential).				antigen processing and presentation|blood coagulation|immune response	integral to plasma membrane|MHC class I protein complex	receptor activity				0			BRCA - Breast invasive adenocarcinoma(18;0.0152)		Drotrecogin alfa(DB00055)	TCCGGCCGGAGAGAGCCTTGT	0.607		NA											40	76					0	0	0	0
CD40	958	broad.mit.edu	37	20	44756788	44756788	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr20:44756788C>T	uc002xrg.1	+	7	648	c.571C>T	c.(571-573)CGG>TGG	p.R191W	CD40_uc002xrh.1_Missense_Mutation_p.S170L|CD40_uc002xri.1_Missense_Mutation_p.S204L|CD40_uc002xrj.1_RNA|CD40_uc002xrk.1_RNA|CD40_uc002xrl.1_RNA	NM_001250	NP_001241	P25942	TNR5_HUMAN	CD40 antigen isoform 1 precursor	191	Extracellular (Potential).				B cell proliferation|cellular response to mechanical stimulus|inflammatory response|platelet activation|positive regulation of endothelial cell apoptosis|positive regulation of I-kappaB kinase/NF-kappaB cascade|protein complex assembly	CD40 receptor complex|extracellular region	enzyme binding|receptor activity			lung(1)|skin(1)	2		Myeloproliferative disorder(115;0.0122)			Simvastatin(DB00641)	TCCCCAGGATCGGCTGAGAGC	0.547		NA							Immune_Deficiency_with_Hyper-IgM		OREG0025991	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	14	102					0	0	0	0
SULF2	55959	broad.mit.edu	37	20	46301111	46301111	+	Silent	SNP	C	C	A			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr20:46301111C>A	uc002xto.2	-	11	1737	c.1407G>T	c.(1405-1407)ACG>ACT	p.T469T	SULF2_uc002xtr.2_Silent_p.T469T|SULF2_uc002xtq.2_Silent_p.T469T	NM_018837	NP_061325	Q8IWU5	SULF2_HUMAN	sulfatase 2 isoform a precursor	469					bone development|heparan sulfate proteoglycan metabolic process|kidney development|negative regulation of fibroblast growth factor receptor signaling pathway	cell surface|endoplasmic reticulum|extracellular space|Golgi stack	arylsulfatase activity|calcium ion binding			ovary(2)|breast(2)|pancreas(1)|skin(1)	6						TCAGCTTCCCCGTGGCGTCCT	0.652		NA											4	31					0.00024832	0.000444785	1	0
COMT	1312	broad.mit.edu	37	22	19950331	19950331	+	Silent	SNP	C	C	T			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr22:19950331C>T	uc002zqu.2	+	3	531	c.282C>T	c.(280-282)GAC>GAT	p.D94D	COMT_uc002zqt.2_Silent_p.D94D|COMT_uc002zqv.2_Silent_p.D94D|COMT_uc002zqw.2_Silent_p.D94D|COMT_uc011ahd.1_Silent_p.D94D|COMT_uc002zqx.2_Silent_p.D94D	NM_000754	NP_000745	P21964	COMT_HUMAN	catechol-O-methyltransferase isoform MB-COMT	94					neurotransmitter biosynthetic process|neurotransmitter catabolic process|xenobiotic metabolic process	cytosol|integral to membrane|intracellular membrane-bounded organelle|microsome|plasma membrane|soluble fraction	catechol O-methyltransferase activity|magnesium ion binding|protein binding			ovary(1)	1	Colorectal(54;0.0993)				Carbidopa(DB00190)|Conjugated Estrogens(DB00286)|Diethylstilbestrol(DB00255)|Dobutamine(DB00841)|Dopamine(DB00988)|Entacapone(DB00494)|Folic Acid(DB00158)|L-Valine(DB00161)|Levodopa(DB01235)|Methyldopa(DB00968)|Modafinil(DB00745)|Morphine(DB00295)|S-Adenosylmethionine(DB00118)|Tolcapone(DB00323)	ACGTGGGCGACAAGAAAGGTG	0.612		NA											7	35					0	0	0	0
HIC2	23119	broad.mit.edu	37	22	21800083	21800083	+	Missense_Mutation	SNP	G	G	T			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr22:21800083G>T	uc002zur.3	+	3	1129	c.899G>T	c.(898-900)GGC>GTC	p.G300V	HIC2_uc002zus.3_Missense_Mutation_p.G300V	NM_015094	NP_055909	Q96JB3	HIC2_HUMAN	hypermethylated in cancer 2	300					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	focal adhesion|nucleus	DNA binding|protein C-terminus binding|zinc ion binding			skin(1)	1	Melanoma(16;0.000465)|Ovarian(15;0.00438)|Colorectal(54;0.0968)	Lung SC(17;0.0262)|all_lung(157;0.205)				GAGCTGGGGGGCACCCCTGAT	0.677		NA											15	41					8.6e-14	1.66e-13	1	0
RGL4	266747	broad.mit.edu	37	22	24034239	24034239	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr22:24034239C>G	uc002zxn.2	+	1	1192	c.22C>G	c.(22-24)CTG>GTG	p.L8V	LOC91316_uc002zxh.3_RNA|LOC91316_uc002zxi.3_RNA|LOC91316_uc002zxk.3_Intron|LOC91316_uc010gua.2_Intron|LOC91316_uc002zxl.3_Intron|LOC91316_uc011aiz.1_Intron|LOC91316_uc002zxm.3_Intron|RGL4_uc002zxo.2_Missense_Mutation_p.L8V|RGL4_uc002zxp.1_Translation_Start_Site|RGL4_uc002zxq.2_Translation_Start_Site	NM_153615	NP_705843	Q8IZJ4	RGDSR_HUMAN	ral guanine nucleotide dissociation	8					small GTPase mediated signal transduction	cytoplasmic membrane-bounded vesicle	guanyl-nucleotide exchange factor activity			ovary(1)	1						GCTCACAAATCTGCCTGCAGC	0.612		NA											23	31					0	0	0	0
TBC1D5	9779	broad.mit.edu	37	3	17418038	17418038	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr3:17418038G>C	uc003cbf.2	-	10	2345	c.680C>G	c.(679-681)GCC>GGC	p.A227G	TBC1D5_uc010hev.2_Missense_Mutation_p.A227G|TBC1D5_uc003cbe.2_Missense_Mutation_p.A227G|TBC1D5_uc010hew.1_Missense_Mutation_p.A179G	NM_014744	NP_055559	Q92609	TBCD5_HUMAN	TBC1 domain family, member 5 isoform b	227	Rab-GAP TBC.					intracellular	protein binding|Rab GTPase activator activity			ovary(1)	1						AGACTCACTGGCATGTAGAAA	0.403		NA											19	36					0	0	0	0
AZI2	64343	broad.mit.edu	37	3	28365639	28365639	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr3:28365639C>T	uc003ceb.2	-	8	1605	c.1073G>A	c.(1072-1074)AGT>AAT	p.S358N	AZI2_uc003cec.2_Missense_Mutation_p.S246N|AZI2_uc003ced.2_3'UTR	NM_022461	NP_071906	Q9H6S1	AZI2_HUMAN	5-azacytidine induced 2 isoform a	358						mitochondrion|plasma membrane				ovary(2)	2						TGCTGTCTCACTTGATTTAGG	0.398		NA											32	43					0	0	0	0
SEMA3B	7869	broad.mit.edu	37	3	50313227	50313227	+	Silent	SNP	G	G	A			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr3:50313227G>A	uc003cyu.2	+	18	2039	c.1797G>A	c.(1795-1797)GCG>GCA	p.A599A	SEMA3B_uc003cyt.2_Silent_p.A598A|SEMA3B_uc003cyv.2_Silent_p.A486A|SEMA3B_uc003cyw.2_Silent_p.A322A|SEMA3B_uc010hli.2_Silent_p.A491A|SEMA3B_uc003cyx.2_Silent_p.A485A|SEMA3B_uc003cyy.2_Silent_p.A256A|SEMA3B_uc011bdo.1_Silent_p.A256A	NM_004636	NP_004627	Q13214	SEM3B_HUMAN	semaphorin 3B isoform 1 precursor	599	Ig-like C2-type.				axon guidance|cell-cell signaling	endoplasmic reticulum|extracellular region|membrane	receptor activity			lung(2)|central_nervous_system(2)|kidney(1)|skin(1)	6				BRCA - Breast invasive adenocarcinoma(193;0.000272)|KIRC - Kidney renal clear cell carcinoma(197;0.00544)|Kidney(197;0.00605)		CGCTGCAGGCGCGCGTGGAGT	0.692		NA											13	19					0	0	0	0
OR5H14	403273	broad.mit.edu	37	3	97868655	97868655	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr3:97868655C>G	uc003dsg.1	+	1	426	c.426C>G	c.(424-426)ATC>ATG	p.I142M		NM_001005514	NP_001005514	A6NHG9	O5H14_HUMAN	olfactory receptor, family 5, subfamily H,	142	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						GACTGTGCATCCGGCTATTAA	0.393		NA											16	162					0	0	0	0
ABI3BP	25890	broad.mit.edu	37	3	100493490	100493490	+	Missense_Mutation	SNP	G	G	T			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr3:100493490G>T	uc003dun.2	-	28	2442	c.2357C>A	c.(2356-2358)CCA>CAA	p.P786Q	ABI3BP_uc003duj.2_Missense_Mutation_p.P366Q|ABI3BP_uc003duk.2_Missense_Mutation_p.P495Q|ABI3BP_uc003dul.2_Missense_Mutation_p.P616Q|ABI3BP_uc011bhd.1_Missense_Mutation_p.P740Q|ABI3BP_uc003dum.2_Missense_Mutation_p.P197Q	NM_015429	NP_056244	Q7Z7G0	TARSH_HUMAN	ABI gene family, member 3 (NESH) binding protein	786						extracellular space				ovary(2)|large_intestine(1)|haematopoietic_and_lymphoid_tissue(1)	4						TTCTCTTGTTGGGCTTGAGCT	0.343		NA											3	8					0.004672	0.0082471	1	0
ILDR1	286676	broad.mit.edu	37	3	121712107	121712107	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr3:121712107G>A	uc003ees.2	-	7	1595	c.1489C>T	c.(1489-1491)CGC>TGC	p.R497C	ILDR1_uc003eeq.2_Missense_Mutation_p.R465C|ILDR1_uc003eer.2_Missense_Mutation_p.R453C|ILDR1_uc010hrg.2_Missense_Mutation_p.R408C	NM_175924	NP_787120	Q86SU0	ILDR1_HUMAN	immunoglobulin-like domain containing receptor	497	Cytoplasmic (Potential).					cytosol|integral to membrane|plasma membrane	receptor activity			skin(1)	1				GBM - Glioblastoma multiforme(114;0.156)		TGCGAGCCGCGGCGGTGGGCC	0.632		NA											10	27					0	0	0	0
SHOX2	6474	broad.mit.edu	37	3	157815817	157815817	+	Silent	SNP	C	C	T			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr3:157815817C>T	uc003fbr.2	-	5	1134	c.995G>A	c.(994-996)TGA>TAA	p.*332*	SHOX2_uc003fbs.2_Silent_p.*356*|SHOX2_uc010hvw.2_Silent_p.*320*	NM_006884	NP_006875	O60902	SHOX2_HUMAN	short stature homeobox 2 isoform a	332					nervous system development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0			Lung(72;0.00318)|LUSC - Lung squamous cell carcinoma(72;0.0043)			GCGTTGGCGTCACAGACCCAG	0.657		NA											141	470					0	0	0	0
NLGN1	22871	broad.mit.edu	37	3	173996813	173996813	+	Missense_Mutation	SNP	A	A	T			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr3:173996813A>T	uc003fio.1	+	6	1445	c.1022A>T	c.(1021-1023)GAA>GTA	p.E341V	NLGN1_uc010hww.1_Missense_Mutation_p.E381V|NLGN1_uc003fip.1_Missense_Mutation_p.E341V	NM_014932	NP_055747	Q8N2Q7	NLGN1_HUMAN	neuroligin 1	358	Extracellular (Potential).				calcium-dependent cell-cell adhesion|neuron cell-cell adhesion|neuronal signal transduction|positive regulation of dendritic spine development|positive regulation of excitatory postsynaptic membrane potential|positive regulation of intracellular protein kinase cascade|positive regulation of synaptogenesis|protein targeting|regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|regulation of N-methyl-D-aspartate selective glutamate receptor activity|synapse assembly|synaptic vesicle targeting	cell junction|cell surface|dendrite|integral to plasma membrane|postsynaptic density|postsynaptic membrane	cell adhesion molecule binding|neurexin binding|receptor activity			lung(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)|ovary(1)|pancreas(1)	7	Ovarian(172;0.0025)		LUSC - Lung squamous cell carcinoma(14;5.36e-13)|Lung(28;9.49e-13)			CCTTACAAAGAACTTGTTGAC	0.423		NA											43	123					0	0	0	0
ATP13A3	79572	broad.mit.edu	37	3	194152587	194152587	+	Missense_Mutation	SNP	T	T	A			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr3:194152587T>A	uc003fty.3	-	21	2682	c.2280A>T	c.(2278-2280)AGA>AGT	p.R760S	ATP13A3_uc003ftz.1_Missense_Mutation_p.R466S	NM_024524	NP_078800	Q9H7F0	AT133_HUMAN	ATPase type 13A3	760					ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			ovary(1)	1	all_cancers(143;6.01e-09)|Ovarian(172;0.0634)	Melanoma(1037;0.211)	OV - Ovarian serous cystadenocarcinoma(49;3.83e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;5.98e-05)		TTCCACAATCTCTGGCCACAG	0.353		NA											10	44					0	0	0	0
DLG1	1739	broad.mit.edu	37	3	197009585	197009585	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr3:197009585C>G	uc003fxo.3	-	4	473	c.283G>C	c.(283-285)GAG>CAG	p.E95Q	DLG1_uc011bud.1_5'UTR|DLG1_uc003fxn.3_Missense_Mutation_p.E95Q|DLG1_uc011bue.1_Missense_Mutation_p.E95Q|DLG1_uc010ial.2_Missense_Mutation_p.E95Q|DLG1_uc011buf.1_RNA|DLG1_uc003fxp.2_RNA|DLG1_uc010iam.1_Missense_Mutation_p.E95Q	NM_001098424	NP_001091894	Q12959	DLG1_HUMAN	discs, large homolog 1 isoform 1	95					actin filament organization|axon guidance|cell-cell adhesion|cortical actin cytoskeleton organization|endothelial cell proliferation|establishment or maintenance of cell polarity|interspecies interaction between organisms|mitotic cell cycle G1/S transition checkpoint|negative regulation of mitotic cell cycle|protein localization in plasma membrane|synaptic transmission|tight junction assembly	basolateral plasma membrane|cytosol|endoplasmic reticulum membrane|immunological synapse|MPP7-DLG1-LIN7 complex|nucleus|postsynaptic density|postsynaptic membrane|sarcolemma|tight junction	cytoskeletal protein binding|guanylate kinase activity|L27 domain binding|phosphatase binding|phosphoprotein phosphatase activity|potassium channel regulator activity|protein binding|protein C-terminus binding|protein kinase binding			ovary(3)	3	all_cancers(143;6.22e-10)|Ovarian(172;0.0418)|Breast(254;0.0589)	Lung NSC(153;0.133)	Epithelial(36;3.23e-24)|all cancers(36;2.15e-22)|OV - Ovarian serous cystadenocarcinoma(49;3.88e-19)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.0148)		GGCAGTGTCTCTGAAGTCACA	0.398		NA											14	150					0	0	0	0
TADA2B	93624	broad.mit.edu	37	4	7056447	7056447	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr4:7056447C>T	uc003gjw.3	+	2	1080	c.929C>T	c.(928-930)GCA>GTA	p.A310V	TADA2B_uc010idi.2_Missense_Mutation_p.A235V	NM_152293	NP_689506	Q86TJ2	TAD2B_HUMAN	transcriptional adaptor 2 (ADA2 homolog,	310					regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|zinc ion binding				0						GAGTACGAGGCAGCGCGGCAT	0.557		NA											28	36					0	0	0	0
POU4F2	5458	broad.mit.edu	37	4	147560567	147560567	+	Missense_Mutation	SNP	T	T	A			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr4:147560567T>A	uc003ikv.2	+	1	523	c.275T>A	c.(274-276)CTT>CAT	p.L92H		NM_004575	NP_004566	Q12837	PO4F2_HUMAN	Brn3b POU domain transcription factor	92					estrogen receptor signaling pathway|MAPKKK cascade|negative regulation of transcription from RNA polymerase II promoter	nuclear speck	RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription			breast(1)	1	all_hematologic(180;0.151)					AGAGCCTGTCTTCCAACCCCA	0.308		NA											14	22					0	0	0	0
TMEM192	201931	broad.mit.edu	37	4	166000814	166000814	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr4:166000814G>C	uc003iqz.3	-	6	911	c.812C>G	c.(811-813)ACG>AGG	p.T271R		NM_001100389	NP_001093859	Q8IY95	TM192_HUMAN	transmembrane protein 192	271	Cytoplasmic (Potential).					Golgi apparatus|integral to membrane|late endosome|lysosomal membrane|nucleus				skin(1)	1	all_hematologic(180;0.221)	Prostate(90;0.0959)|Melanoma(52;0.18)		GBM - Glioblastoma multiforme(119;0.0926)		AGCCTCTCACGTTCTACTTGG	0.527		NA											6	17					0	0	0	0
FAT1	2195	broad.mit.edu	37	4	187627774	187627774	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr4:187627774G>A	uc003izf.2	-	2	3396	c.3208C>T	c.(3208-3210)CGA>TGA	p.R1070*	FAT1_uc010iso.1_Nonsense_Mutation_p.R1070*	NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor	1070	Extracellular (Potential).|Cadherin 9.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12						ATGGAGTATCGGATCTCCCCA	0.443		NA								HNSCC(5;0.00058)			49	70					0	0	0	0
DNAH5	1767	broad.mit.edu	37	5	13719088	13719088	+	Silent	SNP	A	A	G			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr5:13719088A>G	uc003jfd.2	-	72	12444	c.12402T>C	c.(12400-12402)GCT>GCC	p.A4134A	DNAH5_uc003jfc.2_Silent_p.A302A	NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	4134	AAA 6 (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					ACTGCTTATGAGCCTCGGTGG	0.468		NA							Kartagener_syndrome				25	115					0	0	0	0
TRIO	7204	broad.mit.edu	37	5	14387624	14387624	+	Silent	SNP	G	G	A			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr5:14387624G>A	uc003jff.2	+	22	3654	c.3648G>A	c.(3646-3648)GAG>GAA	p.E1216E	TRIO_uc003jfg.2_RNA|TRIO_uc011cna.1_Silent_p.E1167E|TRIO_uc003jfh.1_Silent_p.E865E	NM_007118	NP_009049	O75962	TRIO_HUMAN	triple functional domain (PTPRF interacting)	1216	Spectrin 4.				apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|transmembrane receptor protein tyrosine phosphatase signaling pathway	cytosol	ATP binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			skin(4)|central_nervous_system(3)|ovary(3)|large_intestine(2)|stomach(2)|breast(2)|upper_aerodigestive_tract(1)|kidney(1)	18	Lung NSC(4;0.000742)					ATGCGGCAGAGATAAAAAAAT	0.438		NA											5	137					0	0	0	0
LMBRD2	92255	broad.mit.edu	37	5	36124341	36124341	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr5:36124341G>C	uc003jkb.1	-	7	1189	c.774C>G	c.(772-774)ATC>ATG	p.I258M		NM_001007527	NP_001007528	Q68DH5	LMBD2_HUMAN	LMBR1 domain containing 2	258	Cytoplasmic (Potential).|Potential.					integral to membrane					0	all_lung(31;0.000146)		Epithelial(62;0.0396)|Lung(74;0.111)|all cancers(62;0.115)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			GATTATACTTGATGCTTTCAT	0.269		NA											5	30					0	0	0	0
NIPBL	25836	broad.mit.edu	37	5	37057315	37057315	+	Missense_Mutation	SNP	A	A	G			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr5:37057315A>G	uc003jkl.3	+	43	7790	c.7291A>G	c.(7291-7293)ATA>GTA	p.I2431V	NIPBL_uc003jkk.3_Missense_Mutation_p.I2431V|NIPBL_uc003jkn.2_Missense_Mutation_p.I124V	NM_133433	NP_597677	Q6KC79	NIPBL_HUMAN	delangin isoform A	2431					brain development|cellular protein localization|cellular response to X-ray|cognition|developmental growth|ear morphogenesis|embryonic arm morphogenesis|embryonic digestive tract morphogenesis|external genitalia morphogenesis|eye morphogenesis|face morphogenesis|gall bladder development|maintenance of mitotic sister chromatid cohesion|metanephros development|negative regulation of transcription from RNA polymerase II promoter|outflow tract morphogenesis|positive regulation of histone deacetylation|regulation of developmental growth|regulation of embryonic development|regulation of hair cycle|response to DNA damage stimulus|sensory perception of sound|uterus morphogenesis	SMC loading complex	chromo shadow domain binding|histone deacetylase binding|protein C-terminus binding|protein N-terminus binding			ovary(4)|lung(2)|large_intestine(1)|breast(1)|kidney(1)	9	all_lung(31;0.000447)|Hepatocellular(1;0.108)		Epithelial(62;0.072)|COAD - Colon adenocarcinoma(61;0.14)|all cancers(62;0.191)|Colorectal(62;0.202)			GCTCTTGTATATAGCAGACAA	0.358		NA											13	49					0	0	0	0
ADAMTS6	11174	broad.mit.edu	37	5	64521916	64521916	+	Nonsense_Mutation	SNP	G	G	T			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr5:64521916G>T	uc003jtp.2	-	16	2878	c.2064C>A	c.(2062-2064)TGC>TGA	p.C688*	ADAMTS6_uc003jto.2_RNA|ADAMTS6_uc003jtq.2_RNA|ADAMTS6_uc003jtr.1_Nonsense_Mutation_p.C309*	NM_197941	NP_922932	Q9UKP5	ATS6_HUMAN	ADAM metallopeptidase with thrombospondin type 1	688					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding				0		Lung NSC(167;2.44e-06)|Prostate(74;0.014)|Ovarian(174;0.0549)|Breast(144;0.111)|Colorectal(97;0.235)		Lung(70;0.00942)		GAGCAACCTTGCATTCTCCAT	0.373		NA											14	14					9.05e-12	1.74e-11	1	0
COL4A3BP	10087	broad.mit.edu	37	5	74696051	74696051	+	Silent	SNP	C	C	G			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr5:74696051C>G	uc011csu.1	-	10	1511	c.1089G>C	c.(1087-1089)GGG>GGC	p.G363G	COL4A3BP_uc003kds.2_Silent_p.G363G|COL4A3BP_uc003kdt.2_Silent_p.G491G|COL4A3BP_uc003kdu.2_Silent_p.G363G	NM_005713	NP_005704	Q9Y5P4	C43BP_HUMAN	alpha 3 type IV collagen binding protein isoform	363					ER to Golgi ceramide transport|immune response	cytosol|endoplasmic reticulum membrane|Golgi apparatus	ceramide binding|phosphatidylinositol-4-phosphate binding|protein binding|protein kinase activity			skin(1)	1		all_lung(232;0.00101)|Lung NSC(167;0.00278)|Ovarian(174;0.0129)|Prostate(461;0.174)		OV - Ovarian serous cystadenocarcinoma(47;1e-53)		ATCTATGTGTCCCCACAGAAG	0.348		NA											7	10					0	0	0	0
PCDHA13	56136	broad.mit.edu	37	5	140263365	140263365	+	Silent	SNP	G	G	A			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr5:140263365G>A	uc003lif.2	+	1	1512	c.1512G>A	c.(1510-1512)CTG>CTA	p.L504L	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc003lia.2_Intron|PCDHA12_uc003lic.2_Intron|PCDHA13_uc003lie.1_Silent_p.L504L|PCDHA13_uc003lid.2_Silent_p.L504L	NM_018904	NP_061727	Q9Y5I0	PCDAD_HUMAN	protocadherin alpha 13 isoform 1 precursor	504	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|skin(2)|central_nervous_system(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGCGTGCGCTGTCGAGCTACG	0.672		NA											37	61					0	0	0	0
FCHSD1	89848	broad.mit.edu	37	5	141026991	141026991	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr5:141026991G>A	uc003llk.2	-	9	853	c.802C>T	c.(802-804)CAC>TAC	p.H268Y	FCHSD1_uc010jgg.2_5'UTR|FCHSD1_uc003llj.2_RNA	NM_033449	NP_258260	Q86WN1	FCSD1_HUMAN	FCH and double SH3 domains 1	268									FCHSD1/BRAF(2)	skin(2)|ovary(1)|central_nervous_system(1)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCCCCGCGGTGGGCATGCTCC	0.622		NA											9	10					0	0	0	0
HLA-DOA	3111	broad.mit.edu	37	6	32975992	32975992	+	Silent	SNP	G	G	A			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr6:32975992G>A	uc003ocr.2	-	2	205	c.129C>T	c.(127-129)GGC>GGT	p.G43G	HLA-DOA_uc010juj.2_Silent_p.G13G|HLA-DOA_uc010jui.2_Silent_p.G43G	NM_002119	NP_002110	P06340	DOA_HUMAN	major histocompatibility complex, class II, DO	43	Extracellular (Potential).|Alpha-1.				antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|interferon-gamma-mediated signaling pathway|T cell costimulation|T cell receptor signaling pathway	endosome membrane|integral to membrane|lysosomal membrane|MHC class II protein complex	MHC class II receptor activity				0						GGCCCGAGGCGCCGTAAGACT	0.537		NA											14	47					0	0	0	0
ZNF318	24149	broad.mit.edu	37	6	43322436	43322436	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr6:43322436G>A	uc003oux.2	-	4	2714	c.2636C>T	c.(2635-2637)TCT>TTT	p.S879F	ZNF318_uc003ouw.2_RNA	NM_014345	NP_055160	Q5VUA4	ZN318_HUMAN	zinc finger protein 318	879	Potential.				meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	nucleic acid binding|zinc ion binding			ovary(3)|breast(2)|central_nervous_system(1)|skin(1)	7			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0171)|OV - Ovarian serous cystadenocarcinoma(102;0.0579)			CTTCTCATCAGAGATCTTCTC	0.438		NA											24	43					0	0	0	0
POLH	5429	broad.mit.edu	37	6	43582058	43582058	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr6:43582058G>A	uc003ovq.3	+	11	2210	c.1906G>A	c.(1906-1908)GAG>AAG	p.E636K	POLH_uc010jyu.2_Missense_Mutation_p.E512K|POLH_uc011dvl.1_RNA|POLH_uc003ovr.3_Missense_Mutation_p.E537K	NM_006502	NP_006493	Q9Y253	POLH_HUMAN	DNA-directed DNA polymerase eta	636					DNA replication|DNA synthesis involved in DNA repair|regulation of DNA repair|response to UV-C	cytoplasm|nucleoplasm	damaged DNA binding|DNA-directed DNA polymerase activity|metal ion binding			breast(2)	2	all_cancers(18;1.89e-05)|Lung NSC(15;0.00161)|all_lung(25;0.004)		all cancers(41;0.000753)|Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|STAD - Stomach adenocarcinoma(11;0.0826)|OV - Ovarian serous cystadenocarcinoma(102;0.167)			AGTGCCCTGTGAGAAGTGTGG	0.502		NA						DNA_polymerases_(catalytic_subunits)	Xeroderma_Pigmentosum				32	136					0	0	0	0
PGK2	5232	broad.mit.edu	37	6	49754449	49754449	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr6:49754449C>T	uc003ozu.2	-	1	559	c.452G>A	c.(451-453)CGA>CAA	p.R151Q		NM_138733	NP_620061	P07205	PGK2_HUMAN	phosphoglycerate kinase 2	151					glycolysis	cytosol	ATP binding|phosphoglycerate kinase activity			ovary(1)	1	Lung NSC(77;0.0402)					AAGTGATGCTCGGAAGGCTTC	0.498		NA											19	83					0	0	0	0
GCLC	2729	broad.mit.edu	37	6	53373486	53373486	+	Silent	SNP	G	G	T	rs17879847	byFrequency	TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr6:53373486G>T	uc003pbw.1	-	8	1240	c.852C>A	c.(850-852)CCC>CCA	p.P284P	GCLC_uc003pbv.1_Silent_p.P8P	NM_001498	NP_001489	P48506	GSH1_HUMAN	glutamate-cysteine ligase, catalytic subunit	284					anti-apoptosis|cell redox homeostasis|cysteine metabolic process|glutamate metabolic process|glutathione biosynthetic process|negative regulation of transcription, DNA-dependent|regulation of blood vessel size|response to heat|response to hormone stimulus|response to oxidative stress|xenobiotic metabolic process	cytosol	ADP binding|ATP binding|coenzyme binding|glutamate binding|glutamate-cysteine ligase activity|magnesium ion binding			ovary(1)|central_nervous_system(1)	2	Lung NSC(77;0.0137)				L-Cysteine(DB00151)|L-Glutamic Acid(DB00142)	CTCGGTAAAAGGGAGATGCAG	0.443		NA											13	95					3.27e-08	6.17e-08	1	0
ZBTB2	57621	broad.mit.edu	37	6	151686959	151686959	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr6:151686959G>C	uc003qoh.2	-	3	1377	c.1242C>G	c.(1240-1242)AGC>AGG	p.S414R		NM_020861	NP_065912	Q8N680	ZBTB2_HUMAN	zinc finger and BTB domain containing 2	414					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1			BRCA - Breast invasive adenocarcinoma(37;0.175)	OV - Ovarian serous cystadenocarcinoma(155;2.63e-11)		AAGTGTCGATGCTCTGGTTGA	0.512		NA											7	49					0	0	0	0
TMEM106B	54664	broad.mit.edu	37	7	12263954	12263954	+	Silent	SNP	A	A	G			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr7:12263954A>G	uc011jxk.1	+	5	784	c.384A>G	c.(382-384)GTA>GTG	p.V128V	TMEM106B_uc003ssh.2_Silent_p.V128V	NM_018374	NP_060844	Q9NUM4	T106B_HUMAN	transmembrane protein 106B	128						integral to membrane					0				UCEC - Uterine corpus endometrioid carcinoma (126;0.185)		ACATTGGTGTAAAATCAGCCT	0.343		NA											44	105					0	0	0	0
NPC1L1	29881	broad.mit.edu	37	7	44579405	44579406	+	Missense_Mutation	DNP	GC	GC	AA			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr7:44579405_44579406GC>AA	uc003tlb.2	-	2	646_647	c.590_591GC>TT	c.(589-591)TGC>TTT	p.C197F	NPC1L1_uc003tlc.2_Missense_Mutation_p.C197F|NPC1L1_uc011kbw.1_Missense_Mutation_p.C197F|NPC1L1_uc003tld.2_Missense_Mutation_p.C197F	NM_013389	NP_037521	Q9UHC9	NPCL1_HUMAN	Niemann-Pick C1-like protein 1 isoform 1	197	Extracellular (Potential).				cholesterol biosynthetic process|intestinal cholesterol absorption|lipoprotein metabolic process	apical plasma membrane|cytoplasmic vesicle membrane|integral to membrane	hedgehog receptor activity|protein binding			ovary(3)|central_nervous_system(1)|skin(1)	5					Ezetimibe(DB00973)	GCTGGGCATTGCAAAGGGCAGA	0.634		NA											25	66					0	0	0	0
SLC25A13	10165	broad.mit.edu	37	7	95775995	95775995	+	Missense_Mutation	SNP	T	T	A			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr7:95775995T>A	uc003uof.3	-	14	1516	c.1325A>T	c.(1324-1326)CAG>CTG	p.Q442L	SLC25A13_uc003uog.3_Missense_Mutation_p.Q443L|SLC25A13_uc011kik.1_Missense_Mutation_p.Q334L	NM_014251	NP_055066	Q9UJS0	CMC2_HUMAN	solute carrier family 25, member 13 isoform 2	442	Solcar 2.|Helical; Name=3; (Potential).				ATP biosynthetic process|gluconeogenesis|malate-aspartate shuttle|response to calcium ion	integral to plasma membrane|mitochondrial inner membrane	calcium ion binding|L-aspartate transmembrane transporter activity|L-glutamate transmembrane transporter activity			central_nervous_system(3)|skin(1)	4	all_cancers(62;7.75e-08)|all_epithelial(64;1.16e-07)		STAD - Stomach adenocarcinoma(171;0.194)		L-Aspartic Acid(DB00128)	GAAAATCACCTGGGAGCCTCC	0.433		NA											63	73					0	0	0	0
MYOM2	9172	broad.mit.edu	37	8	2040177	2040177	+	Missense_Mutation	SNP	T	T	C			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr8:2040177T>C	uc003wpx.3	+	16	1970	c.1832T>C	c.(1831-1833)GTC>GCC	p.V611A	MYOM2_uc011kwi.1_Missense_Mutation_p.V36A	NM_003970	NP_003961	P54296	MYOM2_HUMAN	myomesin 2	611					muscle contraction	myosin filament	structural constituent of muscle			ovary(4)|central_nervous_system(1)|skin(1)	6		Ovarian(12;0.0572)|Colorectal(14;0.0844)|Hepatocellular(245;0.217)		BRCA - Breast invasive adenocarcinoma(11;1.85e-05)|Colorectal(4;0.0101)|READ - Rectum adenocarcinoma(4;0.148)|COAD - Colon adenocarcinoma(4;0.179)		CGAAAAGTTGTCCCTTCTGCT	0.557		NA											103	144					0	0	0	0
PRSS55	203074	broad.mit.edu	37	8	10388887	10388887	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr8:10388887C>T	uc003wta.2	+	3	445	c.430C>T	c.(430-432)CTT>TTT	p.L144F	uc010lru.2_Intron|PRSS55_uc003wtb.2_RNA	NM_198464	NP_940866	Q6UWB4	PRS55_HUMAN	hypothetical protein LOC203074 precursor	144	Extracellular (Potential).|Peptidase S1.				proteolysis	integral to membrane	serine-type endopeptidase activity			ovary(1)	1						CAGCATCATTCTTCACAAAGA	0.517		NA											34	155					0	0	0	0
WRN	7486	broad.mit.edu	37	8	30977842	30977842	+	Missense_Mutation	SNP	C	C	A			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr8:30977842C>A	uc003xio.3	+	21	3320	c.2532C>A	c.(2530-2532)GAC>GAA	p.D844E	WRN_uc010lvk.2_Missense_Mutation_p.D311E	NM_000553	NP_000544	Q14191	WRN_HUMAN	Werner syndrome protein	844	Helicase C-terminal.				base-excision repair|cellular response to starvation|DNA recombination|DNA synthesis involved in DNA repair|multicellular organismal aging|nucleolus to nucleoplasm transport|positive regulation of hydrolase activity|regulation of apoptosis|replication fork processing|response to oxidative stress|response to UV-C|telomere maintenance	centrosome|nucleolus|nucleoplasm	3'-5' exonuclease activity|ATP binding|ATP-dependent 3'-5' DNA helicase activity|bubble DNA binding|four-way junction helicase activity|G-quadruplex DNA binding|magnesium ion binding|manganese ion binding|protein complex binding|protein homodimerization activity|Y-form DNA binding			ovary(2)|kidney(2)|large_intestine(1)|lung(1)|skin(1)	7		Breast(100;0.195)		KIRC - Kidney renal clear cell carcinoma(542;0.147)|Kidney(114;0.176)|Colorectal(111;0.192)		CTCCTAAGGACATGGAATCAT	0.423		NA	Mis|N|F|S			osteosarcoma|meningioma|others		Genes_defective_in_diseases_associated_with_sensitivity_to_DNA_damaging_agents	Werner_syndrome				31	72					8.17e-17	1.59e-16	1	0
ARFGEF1	10565	broad.mit.edu	37	8	68150679	68150679	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr8:68150679C>G	uc003xxo.1	-	22	3578	c.3188G>C	c.(3187-3189)GGA>GCA	p.G1063A	ARFGEF1_uc003xxl.1_Missense_Mutation_p.G517A|ARFGEF1_uc003xxn.1_Missense_Mutation_p.G46A	NM_006421	NP_006412	Q9Y6D6	BIG1_HUMAN	brefeldin A-inhibited guanine	1063					exocytosis|regulation of ARF protein signal transduction	cytoplasm	ARF guanyl-nucleotide exchange factor activity|myosin binding			ovary(4)|upper_aerodigestive_tract(1)|large_intestine(1)|lung(1)|kidney(1)	8	Breast(64;0.214)	Lung NSC(129;0.0908)|all_lung(136;0.152)	Epithelial(68;0.0043)|OV - Ovarian serous cystadenocarcinoma(28;0.00578)|all cancers(69;0.0173)|BRCA - Breast invasive adenocarcinoma(89;0.206)			AGGTTTCACTCCAGTTCCTAT	0.393		NA											18	37					0	0	0	0
KCNB2	9312	broad.mit.edu	37	8	73850088	73850088	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr8:73850088G>C	uc003xzb.2	+	3	3086	c.2498G>C	c.(2497-2499)TGC>TCC	p.C833S		NM_004770	NP_004761	Q92953	KCNB2_HUMAN	potassium voltage-gated channel, Shab-related	833	Cytoplasmic (Potential).				regulation of smooth muscle contraction	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|protein binding			skin(3)|large_intestine(1)|pancreas(1)|ovary(1)|central_nervous_system(1)	7	Breast(64;0.137)		Epithelial(68;0.105)			AGCCCAAATTGCTTTGCAGAT	0.537		NA											21	51					0	0	0	0
ZFHX4	79776	broad.mit.edu	37	8	77767248	77767248	+	Silent	SNP	G	G	A			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr8:77767248G>A	uc003yav.2	+	10	8343	c.7956G>A	c.(7954-7956)CGG>CGA	p.R2652R	ZFHX4_uc003yau.1_Silent_p.R2697R|ZFHX4_uc003yaw.1_Silent_p.R2652R	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	2652	C2H2-type 17.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			TTCGCTCTCGGCACTGGAATG	0.512		NA								HNSCC(33;0.089)			17	60					0	0	0	0
OSGIN2	734	broad.mit.edu	37	8	90926441	90926441	+	Silent	SNP	G	G	A			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr8:90926441G>A	uc003yeg.2	+	3	550	c.204G>A	c.(202-204)CAG>CAA	p.Q68Q	OSGIN2_uc003yeh.2_Silent_p.Q112Q	NM_004337	NP_004328	Q9Y236	OSGI2_HUMAN	oxidative stress induced growth inhibitor family	68					germ cell development|meiosis						0			BRCA - Breast invasive adenocarcinoma(11;0.0344)			TTGTTGATCAGGTATTATTTC	0.274		NA											9	29					0	0	0	0
RNF19A	25897	broad.mit.edu	37	8	101299760	101299760	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr8:101299760C>T	uc003yjj.1	-	3	960	c.643G>A	c.(643-645)GAT>AAT	p.D215N	RNF19A_uc003yjk.1_Missense_Mutation_p.D215N|RNF19A_uc003yjl.1_Missense_Mutation_p.D215N	NM_015435	NP_056250	Q9NV58	RN19A_HUMAN	ring finger protein 19	215	IBR-type.				microtubule cytoskeleton organization|protein modification process	centrosome|integral to membrane	ligase activity|transcription factor binding|zinc ion binding			ovary(2)|central_nervous_system(1)|skin(1)	4	all_cancers(14;3.5e-05)|all_epithelial(15;8.91e-08)|Lung NSC(17;0.000615)|all_lung(17;0.00166)		Epithelial(11;3.06e-11)|all cancers(13;5.78e-09)|OV - Ovarian serous cystadenocarcinoma(57;2.24e-05)|STAD - Stomach adenocarcinoma(118;0.0525)			CACCTACAATCAGGATCTGCA	0.358		NA											28	59					0	0	0	0
CSMD3	114788	broad.mit.edu	37	8	113267646	113267646	+	Nonsense_Mutation	SNP	A	A	T			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr8:113267646A>T	uc003ynu.2	-	62	10032	c.9873T>A	c.(9871-9873)TGT>TGA	p.C3291*	CSMD3_uc003yns.2_Nonsense_Mutation_p.C2493*|CSMD3_uc003ynt.2_Nonsense_Mutation_p.C3251*|CSMD3_uc011lhx.1_Nonsense_Mutation_p.C3122*	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	3291	Extracellular (Potential).|Sushi 26.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						CAGGGTCACCACAAAACTTTG	0.363		NA								HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			10	52					0	0	0	0
TRPS1	7227	broad.mit.edu	37	8	116631670	116631670	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr8:116631670C>T	uc003ynz.2	-	2	1075	c.616G>A	c.(616-618)GTG>ATG	p.V206M	TRPS1_uc011lhy.1_Missense_Mutation_p.V210M|TRPS1_uc003yny.2_Missense_Mutation_p.V219M|TRPS1_uc010mcy.2_Missense_Mutation_p.V206M	NM_014112	NP_054831	Q9UHF7	TRPS1_HUMAN	zinc finger transcription factor TRPS1	206					negative regulation of transcription from RNA polymerase II promoter|NLS-bearing substrate import into nucleus|regulation of chondrocyte differentiation|skeletal system development|transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)|skin(2)|pancreas(1)|lung(1)|kidney(1)	7	all_cancers(13;5.44e-23)|all_epithelial(1;2.14e-27)|Lung NSC(37;2.55e-05)|Ovarian(258;0.0219)		Epithelial(1;9.78e-37)|all cancers(1;3.14e-31)|BRCA - Breast invasive adenocarcinoma(1;2.56e-12)			TTGTCATTCACCAGTAAGTCA	0.468		NA							Langer-Giedion_syndrome				29	121					0	0	0	0
COL22A1	169044	broad.mit.edu	37	8	139642988	139642988	+	Missense_Mutation	SNP	C	C	A			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr8:139642988C>A	uc003yvd.2	-	50	4060	c.3613G>T	c.(3613-3615)GCA>TCA	p.A1205S	COL22A1_uc011ljo.1_Missense_Mutation_p.A485S	NM_152888	NP_690848	Q8NFW1	COMA1_HUMAN	collagen, type XXII, alpha 1	1205	Pro-rich.|Gly-rich.|Collagen-like 11.				cell adhesion	collagen|cytoplasm	structural molecule activity			ovary(11)|pancreas(1)|skin(1)	13	all_epithelial(106;1.55e-12)|Lung NSC(106;1.67e-05)|all_lung(105;3.39e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0517)			ATTCCATCTGCCCCCTAAAAA	0.418		NA								HNSCC(7;0.00092)			35	109					4.9e-10	9.39e-10	1	0
PIP5K1B	8395	broad.mit.edu	37	9	71555671	71555671	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr9:71555671C>G	uc004agu.2	+	14	1772	c.1467C>G	c.(1465-1467)CAC>CAG	p.H489Q	PIP5K1B_uc011lrq.1_Missense_Mutation_p.H489Q|PIP5K1B_uc004agv.2_RNA	NM_003558	NP_003549	O14986	PI51B_HUMAN	phosphatidylinositol-4-phosphate 5-kinase, type	489						endomembrane system|membrane|uropod	1-phosphatidylinositol-4-phosphate 5-kinase activity|ATP binding|protein binding			stomach(1)	1				Lung(182;0.133)		TCAATGAGCACTATCCACACG	0.478		NA											33	56					0	0	0	0
TEX10	54881	broad.mit.edu	37	9	103090242	103090242	+	Missense_Mutation	SNP	T	T	C			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr9:103090242T>C	uc004bas.2	-	8	1843	c.1628A>G	c.(1627-1629)TAT>TGT	p.Y543C	TEX10_uc011lvf.1_Missense_Mutation_p.Y382C|TEX10_uc011lvg.1_Missense_Mutation_p.Y546C	NM_017746	NP_060216	Q9NXF1	TEX10_HUMAN	testis expressed 10 isoform 1	543						integral to membrane|MLL1 complex|nuclear membrane|nucleolus	binding			ovary(1)|skin(1)	2		Acute lymphoblastic leukemia(62;0.0527)		OV - Ovarian serous cystadenocarcinoma(323;0.157)		TTTACTACGATATCTTAGAAA	0.328		NA											4	9					0	0	0	0
TUBB2C	10383	broad.mit.edu	37	9	140137973	140137973	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr9:140137973G>A	uc004cmh.1	+	4	1405	c.1303G>A	c.(1303-1305)GAG>AAG	p.E435K	TUBB2C_uc004cmg.1_Missense_Mutation_p.E289K	NM_006088	NP_006079	P68371	TBB2C_HUMAN	tubulin, beta, 2	435					'de novo' posttranslational protein folding|cellular component movement|G2/M transition of mitotic cell cycle|microtubule-based movement|natural killer cell mediated cytotoxicity|protein polymerization	cytosol|microtubule	GTP binding|GTPase activity|MHC class I protein binding|structural molecule activity|unfolded protein binding			ovary(1)	1	all_cancers(76;0.0926)		STAD - Stomach adenocarcinoma(284;0.0698)	OV - Ovarian serous cystadenocarcinoma(145;6.37e-05)|Epithelial(140;0.00057)		GGAGGAGGGCGAGTTCGAGGA	0.587		NA											48	45					0	0	0	0
SLC25A6	293	broad.mit.edu	37	X	1508618	1508618	+	Silent	SNP	G	G	C			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chrX:1508618G>C	uc004cpt.2	-	2	210	c.114C>G	c.(112-114)GTC>GTG	p.V38V	SLC25A6_uc004cpu.2_RNA	NM_001636	NP_001627	P12236	ADT3_HUMAN	adenine nucleotide translocator 3	38	Solcar 1.|Helical; Name=1; (By similarity).				active induction of host immune response by virus|apoptosis|energy reserve metabolic process|regulation of insulin secretion|viral infectious cycle	integral to membrane|mitochondrial inner membrane presequence translocase complex	ATP:ADP antiporter activity|protein binding				0		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)			Clodronate(DB00720)	TGGCGTGCTGGACCTGGGGGA	0.552		NA											26	199					0	0	0	0
FRMPD4	9758	broad.mit.edu	37	X	12735807	12735807	+	Silent	SNP	G	G	A			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chrX:12735807G>A	uc004cuz.1	+	16	3368	c.2862G>A	c.(2860-2862)CCG>CCA	p.P954P	FRMPD4_uc011mij.1_Silent_p.P946P	NM_014728	NP_055543	Q14CM0	FRPD4_HUMAN	FERM and PDZ domain containing 4	954					positive regulation of synapse structural plasticity	cytoskeleton|dendritic spine	phosphatidylinositol-4,5-bisphosphate binding|protein binding			central_nervous_system(5)|ovary(3)|skin(2)|large_intestine(1)|lung(1)|pancreas(1)	13						CCGAGTTCCCGGCCTCCAAGA	0.612		NA											76	42					0	0	0	0
ACOT9	23597	broad.mit.edu	37	X	23724804	23724804	+	Silent	SNP	G	G	A			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chrX:23724804G>A	uc004dap.2	-	10	902	c.756C>T	c.(754-756)GCC>GCT	p.A252A	ACOT9_uc004dan.2_Silent_p.A2A|ACOT9_uc004dao.2_Silent_p.A261A|ACOT9_uc004daq.2_Silent_p.A210A|ACOT9_uc004dar.2_Silent_p.A192A|ACOT9_uc011mjt.1_RNA|ACOT9_uc004das.2_Silent_p.A192A	NM_001033583	NP_001028755	Q9Y305	ACOT9_HUMAN	acyl-Coenzyme A thioesterase 2, mitochondrial	252					acyl-CoA metabolic process	mitochondrion	acetyl-CoA hydrolase activity|carboxylesterase activity			ovary(2)|pancreas(1)	3						CAGCGCTGGGGGCCATTTTCA	0.488		NA											16	44					0	0	0	0
SAT1	6303	broad.mit.edu	37	X	23801827	23801827	+	Splice_Site	SNP	G	G	A			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chrX:23801827G>A	uc004dau.2	+	2	312	c.118_splice	c.e2+1	p.D40_splice	SAT1_uc010nfv.2_Splice_Site_p.D40_splice|SAT1_uc004dav.2_Splice_Site	NM_002970	NP_002961	P21673	SAT1_HUMAN	diamine N-acetyltransferase 1						angiogenesis|polyamine biosynthetic process	cytosol	diamine N-acetyltransferase activity|protein binding				0					Spermine(DB00127)	ACTGAAAAAGGTAATTCAACA	0.488		NA											10	11					0	0	0	0
TRO	7216	broad.mit.edu	37	X	54955857	54955857	+	Silent	SNP	T	T	G			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chrX:54955857T>G	uc004dtq.2	+	12	2807	c.2700T>G	c.(2698-2700)GGT>GGG	p.G900G	TRO_uc004dts.2_Intron|TRO_uc004dtr.2_Intron|TRO_uc004dtt.2_Intron|TRO_uc004dtu.2_Intron|TRO_uc004dtv.2_Intron|TRO_uc011mok.1_Silent_p.G431G|TRO_uc004dtw.2_Silent_p.G503G|TRO_uc004dtx.2_Silent_p.G283G	NM_001039705	NP_001034794	Q12816	TROP_HUMAN	trophinin isoform 5	900	62 X 10 AA approximate tandem repeats.				embryo implantation|homophilic cell adhesion	integral to plasma membrane				ovary(1)	1						TCTGTTTTGGTGGCTCTCCCA	0.557		NA											3	51					0	0	0	0
NAP1L3	4675	broad.mit.edu	37	X	92927031	92927031	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chrX:92927031C>T	uc004efq.2	-	1	1578	c.1273G>A	c.(1273-1275)GGA>AGA	p.G425R	FAM133A_uc004efr.1_5'Flank	NM_004538	NP_004529	Q99457	NP1L3_HUMAN	nucleosome assembly protein 1-like 3	425					nucleosome assembly	chromatin assembly complex				ovary(1)|skin(1)	2						TCAATTTCTCCAGTAGCAGTT	0.443		NA											6	4					0	0	0	0
LUZP4	51213	broad.mit.edu	37	X	114540929	114540929	+	Missense_Mutation	SNP	A	A	G			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chrX:114540929A>G	uc004eqa.2	+	4	536	c.502A>G	c.(502-504)AGA>GGA	p.R168G	LUZP4_uc004eqb.2_Missense_Mutation_p.R86G	NM_016383	NP_057467	Q9P127	LUZP4_HUMAN	leucine zipper protein 4	168						nucleus				ovary(2)	2						CCACTTAGAGAGATCTCTTTC	0.448		NA											41	18					0	0	0	0
RERE	473	broad.mit.edu	37	1	8716109	8716109	+	Frame_Shift_Del	DEL	T	T	-			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr1:8716109delT	uc001ape.2	-	3	1058	c.248delA	c.(247-249)AAGfs	p.K83fs	RERE_uc001apf.2_Frame_Shift_Del_p.K83fs|RERE_uc001aph.1_Frame_Shift_Del_p.K83fs	NM_012102	NP_036234	Q9P2R6	RERE_HUMAN	atrophin-1 like protein isoform a	83					multicellular organismal development|NLS-bearing substrate import into nucleus	mitochondrion	poly-glutamine tract binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2	Ovarian(185;0.0661)	all_epithelial(116;1.17e-21)|all_lung(118;1.4e-06)|Lung NSC(185;3.06e-06)|Renal(390;0.000147)|Breast(348;0.000206)|Colorectal(325;0.00187)|Hepatocellular(190;0.00825)|Ovarian(437;0.0253)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;9.64e-67)|GBM - Glioblastoma multiforme(8;9.89e-33)|Colorectal(212;1.45e-07)|COAD - Colon adenocarcinoma(227;3.42e-05)|Kidney(185;6e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000533)|KIRC - Kidney renal clear cell carcinoma(229;0.00106)|STAD - Stomach adenocarcinoma(132;0.00118)|READ - Rectum adenocarcinoma(331;0.0419)|Lung(427;0.195)		ATAACGAGACTTTTTTTTCGG	0.453		NA											9	367	---	---	---	---	NA	NA	NA	NA
RBBP4	5928	broad.mit.edu	37	1	33134662	33134664	+	In_Frame_Del	DEL	AGA	AGA	-			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr1:33134662_33134664delAGA	uc001bvr.2	+	6	849_851	c.690_692delAGA	c.(688-693)GTAGAA>GTA	p.E231del	RBBP4_uc001bvs.2_In_Frame_Del_p.E230del|RBBP4_uc010ohj.1_5'UTR|RBBP4_uc010ohk.1_In_Frame_Del_p.E196del	NM_005610	NP_005601	Q09028	RBBP4_HUMAN	retinoblastoma binding protein 4 isoform a	231	WD 3.				cell cycle|CenH3-containing nucleosome assembly at centromere|DNA replication|negative regulation of cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	CAF-1 complex|ESC/E(Z) complex|NuRD complex|NURF complex|Sin3 complex	histone binding|histone deacetylase binding			ovary(1)	1		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)				CGGCAGTAGTAGAAGATGTTTCC	0.433		NA											24	60	---	---	---	---	NA	NA	NA	NA
PRPF38B	55119	broad.mit.edu	37	1	109241970	109241980	+	Frame_Shift_Del	DEL	GGGGTTAGAAC	GGGGTTAGAAC	-	rs3210429		TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr1:109241970_109241980delGGGGTTAGAAC	uc001dvv.3	+	6	1251_1261	c.969_979delGGGGTTAGAAC	c.(967-981)CGGGGGTTAGAACGCfs	p.R323fs	PRPF38B_uc001dvw.3_Frame_Shift_Del_p.R212fs|PRPF38B_uc010ouz.1_Frame_Shift_Del_p.R126fs	NM_018061	NP_060531	Q5VTL8	PR38B_HUMAN	PRP38 pre-mRNA processing factor 38 (yeast)	323_327	Arg-rich.				mRNA processing|RNA splicing	spliceosomal complex					0		all_epithelial(167;0.000154)|all_lung(203;0.00026)|Lung NSC(277;0.000508)		Colorectal(144;0.0149)|Lung(183;0.0888)|COAD - Colon adenocarcinoma(174;0.113)|Epithelial(280;0.161)		GTATTGACCGGGGGTTAGAACGCAGGCGCAG	0.422		NA											22	42	---	---	---	---	NA	NA	NA	NA
SYT16	83851	broad.mit.edu	37	14	62541956	62541957	+	Frame_Shift_Ins	INS	-	-	A			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr14:62541956_62541957insA	uc001xfu.1	+	3	1037_1038	c.840_841insA	c.(838-843)GCCAAAfs	p.A280fs	SYT16_uc010tsd.1_Frame_Shift_Ins_p.A280fs	NM_031914	NP_114120	Q17RD7	SYT16_HUMAN	synaptotagmin XIV-like	280_281										central_nervous_system(1)	1				OV - Ovarian serous cystadenocarcinoma(108;0.0438)|BRCA - Breast invasive adenocarcinoma(234;0.118)		GAGGGGATGCCAAACACCACGG	0.545		NA											12	26	---	---	---	---	NA	NA	NA	NA
HYDIN	54768	broad.mit.edu	37	16	71212876	71212876	+	Frame_Shift_Del	DEL	G	G	-			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr16:71212876delG	uc002ezr.2	-	4	464	c.336delC	c.(334-336)CCCfs	p.P112fs	HYDIN_uc010cfz.1_5'UTR|HYDIN_uc002ezv.2_Frame_Shift_Del_p.P112fs|HYDIN_uc010vmc.1_Frame_Shift_Del_p.P129fs|HYDIN_uc010vmd.1_Frame_Shift_Del_p.P139fs|HYDIN_uc002ezw.3_Frame_Shift_Del_p.P129fs	NM_032821	NP_116210	Q4G0P3	HYDIN_HUMAN	hydrocephalus inducing isoform a	112										ovary(1)|skin(1)	2		Ovarian(137;0.0654)				AGACTTCACAGGGAGTGTAGT	0.388		NA											13	122	---	---	---	---	NA	NA	NA	NA
TP53	7157	broad.mit.edu	37	17	7579718	7579718	+	Frame_Shift_Del	DEL	A	A	-			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr17:7579718delA	uc002gim.2	-	3	272	c.78delT	c.(76-78)CTTfs	p.L26fs	TP53_uc002gig.1_Frame_Shift_Del_p.L26fs|TP53_uc002gih.2_Frame_Shift_Del_p.L26fs|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_5'Flank|TP53_uc010cng.1_5'Flank|TP53_uc002gii.1_5'Flank|TP53_uc010cnh.1_Frame_Shift_Del_p.L26fs|TP53_uc010cni.1_Frame_Shift_Del_p.L26fs|TP53_uc002gij.2_Frame_Shift_Del_p.L26fs|TP53_uc010cnj.1_5'Flank|TP53_uc002gin.2_Frame_Shift_Del_p.L26fs|TP53_uc002gio.2_Intron|TP53_uc010vug.1_5'UTR|TP53_uc010cnk.1_Frame_Shift_Del_p.L41fs	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	26	Transcription activation (acidic).|Interaction with HRMT1L2.				activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.0?(7)|p.L26fs*18(1)|p.P13fs*18(1)|p.L26fs*11(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		TGTTTTCAGGAAGTCTGAAAG	0.408		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			23	28	---	---	---	---	NA	NA	NA	NA
C4orf21	55345	broad.mit.edu	37	4	113540154	113540155	+	Frame_Shift_Del	DEL	TG	TG	-			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr4:113540154_113540155delTG	uc003iau.2	-	6	1254_1255	c.1043_1044delCA	c.(1042-1044)ACAfs	p.T348fs	C4orf21_uc003iaw.2_Frame_Shift_Del_p.T348fs	NM_018392	NP_060862	Q6ZU11	YD002_HUMAN	prematurely terminated mRNA decay factor-like	Error:Variant_position_missing_in_Q6ZU11_after_alignment						integral to membrane	zinc ion binding				0		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.000676)		GTTTCCTTTCTGTATCATTCCC	0.366		NA											23	41	---	---	---	---	NA	NA	NA	NA
LRP12	29967	broad.mit.edu	37	8	105503080	105503081	+	Frame_Shift_Ins	INS	-	-	TGAG			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr8:105503080_105503081insTGAG	uc003yma.2	-	7	2495_2496	c.2400_2401insCTCA	c.(2398-2403)TCAGATfs	p.S800fs	LRP12_uc003ymb.2_Frame_Shift_Ins_p.S781fs|LRP12_uc003ylz.2_Frame_Shift_Ins_p.S206fs	NM_013437	NP_038465	Q9Y561	LRP12_HUMAN	low density lipoprotein-related protein 12	800_801	Cytoplasmic (Potential).				endocytosis|regulation of growth	coated pit|integral to plasma membrane	low-density lipoprotein receptor activity|protein binding				0			OV - Ovarian serous cystadenocarcinoma(57;1.21e-06)|STAD - Stomach adenocarcinoma(118;0.229)			TGTCCTTGATCTGAGGCAAGAT	0.441		NA											26	80	---	---	---	---	NA	NA	NA	NA
CSMD3	114788	broad.mit.edu	37	8	113259327	113259328	+	Frame_Shift_Ins	INS	-	-	T	rs142018478		TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr8:113259327_113259328insT	uc003ynu.2	-	64	10302_10303	c.10143_10144insA	c.(10141-10146)AAAGGAfs	p.K3381fs	CSMD3_uc003yns.2_Frame_Shift_Ins_p.K2583fs|CSMD3_uc003ynt.2_Frame_Shift_Ins_p.K3341fs|CSMD3_uc011lhx.1_Frame_Shift_Ins_p.K3212fs	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	3381_3382	Extracellular (Potential).|Sushi 27.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						AGAAGGTGTCCTTTTTTGCAAT	0.406		NA								HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			17	49	---	---	---	---	NA	NA	NA	NA
LHX6	26468	broad.mit.edu	37	9	124989225	124989225	+	Frame_Shift_Del	DEL	C	C	-			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr9:124989225delC	uc010mvw.2	-	2	263	c.154delG	c.(154-156)GTCfs	p.V52fs	LHX6_uc004blx.3_Frame_Shift_Del_p.V81fs|LHX6_uc004bly.3_Frame_Shift_Del_p.V81fs	NM_014368	NP_055183	Q9UPM6	LHX6_HUMAN	LIM homeobox protein 6 isoform 1	52					cell maturation|cerebral cortex GABAergic interneuron migration|cerebral cortex radially oriented cell migration|cerebral cortex tangential migration	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0						GGTGAGCAGACAGATGGCGTG	0.662		NA											2	4	---	---	---	---	NA	NA	NA	NA