Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	isArtifactMode	oxoGCut
HIVEP3	59269	broad.mit.edu	37	1	42047570	42047570	+	Missense_Mutation	SNP	G	G	A	rs141506685	byFrequency	TCGA-CV-7236-01A-11D-2012-08	TCGA-CV-7236-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dc220a9d-1f16-4fe3-8196-d837a909f038	360144da-2c0b-4e18-81b5-5dde9d7a3682	g.chr1:42047570G>A	uc001cgz.3	-	4	4112	c.2899C>T	c.(2899-2901)CGC>TGC	p.R967C	HIVEP3_uc001cha.3_Missense_Mutation_p.R967C|HIVEP3_uc001cgy.2_RNA	NM_024503	NP_078779	Q5T1R4	ZEP3_HUMAN	human immunodeficiency virus type I enhancer	967	No DNA binding activity or transactivation activity, but complete prevention of TRAF-dependent NF-Kappa-B activation; associates with TRAF2 and JUN (By similarity).				positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			ovary(4)|large_intestine(1)|central_nervous_system(1)	6	Ovarian(52;0.00769)|all_hematologic(146;0.109)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0367)				GGTTTGGGGCGCATGTCAGAT	0.612		NA											4	110					0	0	0	0
IPO13	9670	broad.mit.edu	37	1	44433123	44433123	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7236-01A-11D-2012-08	TCGA-CV-7236-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dc220a9d-1f16-4fe3-8196-d837a909f038	360144da-2c0b-4e18-81b5-5dde9d7a3682	g.chr1:44433123G>A	uc001ckx.2	+	19	3545	c.2750G>A	c.(2749-2751)CGC>CAC	p.R917H	IPO13_uc001cky.2_Missense_Mutation_p.R135H	NM_014652	NP_055467	O94829	IPO13_HUMAN	importin 13	917					protein import into nucleus	cytoplasm|nucleus	protein binding|protein transporter activity			central_nervous_system(1)	1	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0821)				CCCTCTGCCCGCCTCAGCCCT	0.617		NA											8	55					0	0	0	0
HRNR	388697	broad.mit.edu	37	1	152188024	152188024	+	Silent	SNP	C	C	T	rs142170860		TCGA-CV-7236-01A-11D-2012-08	TCGA-CV-7236-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dc220a9d-1f16-4fe3-8196-d837a909f038	360144da-2c0b-4e18-81b5-5dde9d7a3682	g.chr1:152188024C>T	uc001ezt.1	-	3	6157	c.6081G>A	c.(6079-6081)TCG>TCA	p.S2027S		NM_001009931	NP_001009931	Q86YZ3	HORN_HUMAN	hornerin	2027	22				keratinization		calcium ion binding|protein binding			skin(2)|ovary(1)	3	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GGCCACAGCTCGATGACTGTC	0.562		NA											56	618					0	0	0	0
SPTA1	6708	broad.mit.edu	37	1	158621162	158621162	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7236-01A-11D-2012-08	TCGA-CV-7236-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dc220a9d-1f16-4fe3-8196-d837a909f038	360144da-2c0b-4e18-81b5-5dde9d7a3682	g.chr1:158621162G>A	uc001fst.1	-	24	3671	c.3472C>T	c.(3472-3474)CGG>TGG	p.R1158W		NM_003126	NP_003117	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1	1158	Spectrin 11.				actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|breast(1)	8	all_hematologic(112;0.0378)					GTTACCTGCCGGATTTGAGCT	0.458		NA											21	194					0	0	0	0
USH2A	7399	broad.mit.edu	37	1	215847770	215847770	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7236-01A-11D-2012-08	TCGA-CV-7236-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dc220a9d-1f16-4fe3-8196-d837a909f038	360144da-2c0b-4e18-81b5-5dde9d7a3682	g.chr1:215847770G>A	uc001hku.1	-	63	13870	c.13483C>T	c.(13483-13485)CGT>TGT	p.R4495C		NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	4495	Fibronectin type-III 30.|Extracellular (Potential).				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		GTAAAATCACGATAGCGTGTT	0.458		NA								HNSCC(13;0.011)			28	165					0	0	0	0
PLCE1	51196	broad.mit.edu	37	10	96014690	96014690	+	Silent	SNP	C	C	A			TCGA-CV-7236-01A-11D-2012-08	TCGA-CV-7236-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dc220a9d-1f16-4fe3-8196-d837a909f038	360144da-2c0b-4e18-81b5-5dde9d7a3682	g.chr10:96014690C>A	uc001kjk.2	+	11	4072	c.3438C>A	c.(3436-3438)TCC>TCA	p.S1146S	PLCE1_uc010qnx.1_Silent_p.S1146S|PLCE1_uc001kjm.2_Silent_p.S838S	NM_016341	NP_057425	Q9P212	PLCE1_HUMAN	phospholipase C, epsilon 1 isoform 1	1146					activation of MAPK activity|activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|calcium-mediated signaling|cell proliferation|cytoskeleton organization|diacylglycerol biosynthetic process|elevation of cytosolic calcium ion concentration|epidermal growth factor receptor signaling pathway|glomerulus development|heart development|lipid catabolic process|Ras protein signal transduction|regulation of cell growth|regulation of G-protein coupled receptor protein signaling pathway|regulation of Ras protein signal transduction|regulation of smooth muscle contraction	cytosol|Golgi membrane|membrane fraction|plasma membrane	calcium ion binding|guanyl-nucleotide exchange factor activity|phosphatidylinositol phospholipase C activity|Ras GTPase binding|receptor signaling protein activity			ovary(2)|skin(1)	3		Colorectal(252;0.0458)				CCCTCCCTTCCAGAAGAGCCC	0.532		NA											21	200					2.71e-06	3.31e-06	1	0
MUC5B	727897	broad.mit.edu	37	11	1262890	1262890	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7236-01A-11D-2012-08	TCGA-CV-7236-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dc220a9d-1f16-4fe3-8196-d837a909f038	360144da-2c0b-4e18-81b5-5dde9d7a3682	g.chr11:1262890C>T	uc009ycr.1	+	47	6985	c.6859C>T	c.(6859-6861)CGG>TGG	p.R2287W	MUC5B_uc001ltb.2_Missense_Mutation_p.R1597W	NM_017511	NP_059981	Q9HC84	MUC5B_HUMAN	SubName: Full=Mucin 5AC, oligomeric mucus/gel-forming;	1594	7 X Cys-rich subdomain repeats.|Cys-rich subdomain 2.				cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding				0		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		CTACAGGATCCGGGTCCTCTG	0.637		NA											4	27					0	0	0	0
ZNF215	7762	broad.mit.edu	37	11	6977595	6977595	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CV-7236-01A-11D-2012-08	TCGA-CV-7236-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dc220a9d-1f16-4fe3-8196-d837a909f038	360144da-2c0b-4e18-81b5-5dde9d7a3682	g.chr11:6977595C>T	uc001mey.2	+	7	1975	c.1387C>T	c.(1387-1389)CAA>TAA	p.Q463*	ZNF215_uc010raw.1_3'UTR|ZNF215_uc010rax.1_Nonsense_Mutation_p.Q225*|ZNF215_uc001mez.1_Intron	NM_013250	NP_037382	Q9UL58	ZN215_HUMAN	zinc finger protein 215	463	C2H2-type 3.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0				Epithelial(150;6.33e-08)|BRCA - Breast invasive adenocarcinoma(625;0.134)		CAATTTCTATCAATGTGTTAA	0.398		NA											5	65					0	0	0	0
FSHB	2488	broad.mit.edu	37	11	30255210	30255210	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7236-01A-11D-2012-08	TCGA-CV-7236-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dc220a9d-1f16-4fe3-8196-d837a909f038	360144da-2c0b-4e18-81b5-5dde9d7a3682	g.chr11:30255210G>A	uc001msl.2	+	3	322	c.253G>A	c.(253-255)GCT>ACT	p.A85T	FSHB_uc001msm.2_Missense_Mutation_p.A85T|FSHB_uc001msn.2_Missense_Mutation_p.A85T	NM_000510	NP_000501	P01225	FSHB_HUMAN	follicle stimulating hormone, beta polypeptide	85					cellular nitrogen compound metabolic process|female gamete generation|female pregnancy|ovarian follicle development|peptide hormone processing|progesterone biosynthetic process|spermatogenesis|transforming growth factor beta receptor signaling pathway	cytoplasm|extracellular region|soluble fraction	follicle-stimulating hormone activity|protein heterodimerization activity			ovary(3)	3					Follitropin beta(DB00066)|Thyrotropin Alfa(DB00024)|Urofollitropin(DB00094)	GCCCGGCTGTGCTCACCATGC	0.527		NA											6	63					0	0	0	0
OR1S1	219959	broad.mit.edu	37	11	57982768	57982768	+	Missense_Mutation	SNP	C	C	A			TCGA-CV-7236-01A-11D-2012-08	TCGA-CV-7236-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dc220a9d-1f16-4fe3-8196-d837a909f038	360144da-2c0b-4e18-81b5-5dde9d7a3682	g.chr11:57982768C>A	uc010rkc.1	+	1	552	c.552C>A	c.(550-552)CAC>CAA	p.H184Q		NM_001004458	NP_001004458	Q8NH92	OR1S1_HUMAN	olfactory receptor, family 1, subfamily S,	184	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)	1		Breast(21;0.0589)				TCTGTAACCACAACACTCTCC	0.438		NA											35	117					1.22e-17	1.53e-17	1	0
MEN1	4221	broad.mit.edu	37	11	64572117	64572117	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CV-7236-01A-11D-2012-08	TCGA-CV-7236-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dc220a9d-1f16-4fe3-8196-d837a909f038	360144da-2c0b-4e18-81b5-5dde9d7a3682	g.chr11:64572117G>A	uc001obj.2	-	10	1610	c.1537C>T	c.(1537-1539)CAG>TAG	p.Q513*	MAP4K2_uc001obh.2_5'Flank|MAP4K2_uc001obi.2_5'Flank|MAP4K2_uc010rnp.1_5'Flank|MEN1_uc001obk.2_Nonsense_Mutation_p.Q513*|MEN1_uc001obl.2_Nonsense_Mutation_p.Q473*|MEN1_uc001obm.2_Nonsense_Mutation_p.Q508*|MEN1_uc001obn.2_Nonsense_Mutation_p.Q513*|MEN1_uc001obo.2_Nonsense_Mutation_p.Q513*|MEN1_uc001obp.2_Nonsense_Mutation_p.Q508*|MEN1_uc001obq.2_Nonsense_Mutation_p.Q513*|MEN1_uc001obr.2_Nonsense_Mutation_p.Q513*	NM_130800	NP_570712	O00255	MEN1_HUMAN	menin isoform 1	513					DNA repair|histone lysine methylation|MAPKKK cascade|negative regulation of cell proliferation|negative regulation of cyclin-dependent protein kinase activity|negative regulation of JNK cascade|negative regulation of osteoblast differentiation|negative regulation of protein phosphorylation|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of telomerase activity|negative regulation of transcription from RNA polymerase II promoter|osteoblast development|positive regulation of protein binding|positive regulation of transforming growth factor beta receptor signaling pathway|response to gamma radiation|response to UV|transcription, DNA-dependent	chromatin|cleavage furrow|cytosol|histone methyltransferase complex|nuclear matrix|soluble fraction	double-stranded DNA binding|four-way junction DNA binding|protein binding, bridging|protein N-terminus binding|R-SMAD binding|transcription regulatory region DNA binding|Y-form DNA binding			parathyroid(105)|pancreas(64)|gastrointestinal_tract_(site_indeterminate)(15)|small_intestine(13)|lung(9)|pituitary(7)|NS(7)|adrenal_gland(5)|soft_tissue(4)|central_nervous_system(4)|thymus(2)|stomach(1)|retroperitoneum(1)|skin(1)	238						ACTGCACCCTGGCCGGTGCCC	0.736		NA	D|Mis|N|F|S		parathyroid tumors|Pancreatic neuroendocrine tumors	parathyroid adenoma|pituitary adenoma|pancreatic islet cell|carcinoid			Hyperparathyroidism_Familial_Isolated|Multiple_Endocrine_Neoplasia_type_1				3	32					0	0	0	0
NCKAP5L	57701	broad.mit.edu	37	12	50191005	50191005	+	Missense_Mutation	SNP	C	C	A	rs78047311		TCGA-CV-7236-01A-11D-2012-08	TCGA-CV-7236-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dc220a9d-1f16-4fe3-8196-d837a909f038	360144da-2c0b-4e18-81b5-5dde9d7a3682	g.chr12:50191005C>A	uc009zlk.2	-	8	840	c.638G>T	c.(637-639)CGG>CTG	p.R213L	NCKAP5L_uc001rvc.3_5'Flank|NCKAP5L_uc001rvb.2_5'UTR	NM_001037806	NP_001032895	Q9HCH0	NCK5L_HUMAN	NCK-associated protein 5-like	209	Pro-rich.									central_nervous_system(1)	1						GCCTGGAGGCCGCCAGGGGGT	0.667		NA											5	55					1.24e-05	1.51e-05	1	0
C12orf56	115749	broad.mit.edu	37	12	64661051	64661051	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7236-01A-11D-2012-08	TCGA-CV-7236-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dc220a9d-1f16-4fe3-8196-d837a909f038	360144da-2c0b-4e18-81b5-5dde9d7a3682	g.chr12:64661051G>A	uc001ssa.3	-	11	1301	c.1301C>T	c.(1300-1302)CCA>CTA	p.P434L	uc001srx.2_Intron|C12orf56_uc001sry.2_Missense_Mutation_p.P176L|C12orf56_uc001srz.2_Missense_Mutation_p.P76L	NM_001099676	NP_001093146	Q8IXR9	CL056_HUMAN	hypothetical protein LOC115749	597											0			GBM - Glioblastoma multiforme(3;0.000582)	GBM - Glioblastoma multiforme(28;0.0259)		CTGCAAGGCTGGCATGTGAAT	0.353		NA											4	17					0	0	0	0
SFRS9	8683	broad.mit.edu	37	12	120901793	120901793	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7236-01A-11D-2012-08	TCGA-CV-7236-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dc220a9d-1f16-4fe3-8196-d837a909f038	360144da-2c0b-4e18-81b5-5dde9d7a3682	g.chr12:120901793G>A	uc001tyi.2	-	3	628	c.482C>T	c.(481-483)GCC>GTC	p.A161V		NM_003769	NP_003760	Q13242	SRSF9_HUMAN	splicing factor, arginine/serine-rich 9	161	RRM 2.				mRNA 3'-end processing|mRNA export from nucleus|mRNA splice site selection|termination of RNA polymerase II transcription	nucleoplasm	nucleotide binding|RNA binding				0	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					TTTACGCAGGGCATATTCCAT	0.488		NA											5	192					0	0	0	0
NUPL1	9818	broad.mit.edu	37	13	25875965	25875965	+	Silent	SNP	C	C	T			TCGA-CV-7236-01A-11D-2012-08	TCGA-CV-7236-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dc220a9d-1f16-4fe3-8196-d837a909f038	360144da-2c0b-4e18-81b5-5dde9d7a3682	g.chr13:25875965C>T	uc001uqi.2	+	1	300	c.54C>T	c.(52-54)GCC>GCT	p.A18A	NUPL1_uc001uqg.1_Silent_p.A18A|NUPL1_uc001uqj.2_Silent_p.A18A	NM_014089	NP_054808	Q9BVL2	NUPL1_HUMAN	nucleoporin like 1 isoform a	18	14 X 2 AA repeats of F-G.				carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear membrane|nuclear pore					0		Lung SC(185;0.0225)|Breast(139;0.0351)		all cancers(112;0.0092)|Epithelial(112;0.0477)|OV - Ovarian serous cystadenocarcinoma(117;0.165)|GBM - Glioblastoma multiforme(144;0.244)		CCACCGTGGCCGCCGGCGGGA	0.667		NA											4	34					0	0	0	0
GPC5	2262	broad.mit.edu	37	13	92346021	92346021	+	Silent	SNP	C	C	T			TCGA-CV-7236-01A-11D-2012-08	TCGA-CV-7236-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dc220a9d-1f16-4fe3-8196-d837a909f038	360144da-2c0b-4e18-81b5-5dde9d7a3682	g.chr13:92346021C>T	uc010tif.1	+	3	1272	c.906C>T	c.(904-906)CTC>CTT	p.L302L		NM_004466	NP_004457	P78333	GPC5_HUMAN	glypican 5 precursor	302						anchored to membrane|extracellular space|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding			ovary(2)|skin(2)|upper_aerodigestive_tract(1)	5	all_cancers(3;1.43e-07)|all_neural(89;0.0804)|Medulloblastoma(90;0.163)	Lung NSC(4;0.00454)				TGGAAGAACTCTCGGATGCAA	0.493		NA											17	76					0	0	0	0
OR4N2	390429	broad.mit.edu	37	14	20296100	20296100	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7236-01A-11D-2012-08	TCGA-CV-7236-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dc220a9d-1f16-4fe3-8196-d837a909f038	360144da-2c0b-4e18-81b5-5dde9d7a3682	g.chr14:20296100C>T	uc010tkv.1	+	1	493	c.493C>T	c.(493-495)CGC>TGC	p.R165C		NM_001004723	NP_001004723	Q8NGD1	OR4N2_HUMAN	olfactory receptor, family 4, subfamily N,	165	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|central_nervous_system(1)|skin(1)	4	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		CCTCATCCTCCGCTTGCCTTT	0.517		NA											14	239					0	0	0	0
MYH7	4625	broad.mit.edu	37	14	23891477	23891477	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7236-01A-11D-2012-08	TCGA-CV-7236-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dc220a9d-1f16-4fe3-8196-d837a909f038	360144da-2c0b-4e18-81b5-5dde9d7a3682	g.chr14:23891477G>A	uc001wjx.2	-	25	3263	c.3157C>T	c.(3157-3159)CGG>TGG	p.R1053W		NM_000257	NP_000248	P12883	MYH7_HUMAN	myosin, heavy chain 7, cardiac muscle, beta	1053	Potential.				adult heart development|muscle filament sliding|regulation of heart rate|ventricular cardiac muscle tissue morphogenesis	focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(3)|skin(1)	4	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00725)		TCCAGCTTCCGCTTCGCTCGC	0.582		NA											9	61					0	0	0	0
PRKCH	5583	broad.mit.edu	37	14	61952305	61952305	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7236-01A-11D-2012-08	TCGA-CV-7236-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dc220a9d-1f16-4fe3-8196-d837a909f038	360144da-2c0b-4e18-81b5-5dde9d7a3682	g.chr14:61952305G>A	uc001xfn.2	+	10	1669	c.1364G>A	c.(1363-1365)CGA>CAA	p.R455Q	PRKCH_uc010tsa.1_Missense_Mutation_p.R294Q|PRKCH_uc010tsb.1_Missense_Mutation_p.R23Q	NM_006255	NP_006246	P24723	KPCL_HUMAN	protein kinase C, eta	455	Protein kinase.				intracellular signal transduction|platelet activation	cytosol|plasma membrane	ATP binding|enzyme binding|metal ion binding|protein kinase C activity			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|lung(1)|large_intestine(1)|skin(1)	6				OV - Ovarian serous cystadenocarcinoma(108;0.045)|BRCA - Breast invasive adenocarcinoma(234;0.0906)|KIRC - Kidney renal clear cell carcinoma(182;0.182)		GATGAAGCACGAGCTCGCTTC	0.433		NA											40	215					0	0	0	0
ABCD4	5826	broad.mit.edu	37	14	74757040	74757040	+	Silent	SNP	C	C	T			TCGA-CV-7236-01A-11D-2012-08	TCGA-CV-7236-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dc220a9d-1f16-4fe3-8196-d837a909f038	360144da-2c0b-4e18-81b5-5dde9d7a3682	g.chr14:74757040C>T	uc001xpr.2	-	12	1433	c.1281G>A	c.(1279-1281)AAG>AAA	p.K427K	ABCD4_uc001xps.2_Silent_p.K268K|ABCD4_uc001xpt.2_Silent_p.K268K|ABCD4_uc010tur.1_Silent_p.K323K|ABCD4_uc001xpu.2_Silent_p.K164K	NM_005050	NP_005041	O14678	ABCD4_HUMAN	ATP-binding cassette, sub-family D, member 4	427	ABC transporter.|ATP (Potential).					ATP-binding cassette (ABC) transporter complex|integral to membrane|peroxisomal membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			upper_aerodigestive_tract(2)|large_intestine(1)|ovary(1)	4				BRCA - Breast invasive adenocarcinoma(234;0.00153)		GCAAGGAGGTCTTGCCAGTGC	0.627		NA									OREG0022800	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	26	128					0	0	0	0
CASC5	57082	broad.mit.edu	37	15	40954309	40954309	+	Silent	SNP	C	C	T			TCGA-CV-7236-01A-11D-2012-08	TCGA-CV-7236-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dc220a9d-1f16-4fe3-8196-d837a909f038	360144da-2c0b-4e18-81b5-5dde9d7a3682	g.chr15:40954309C>T	uc010bbs.1	+	27	7113	c.6952C>T	c.(6952-6954)CTG>TTG	p.L2318L	CASC5_uc010bbt.1_Silent_p.L2292L	NM_170589	NP_733468	Q8NG31	CASC5_HUMAN	cancer susceptibility candidate 5 isoform 1	2318					acrosome assembly|attachment of spindle microtubules to kinetochore|cell division|CenH3-containing nucleosome assembly at centromere|mitotic prometaphase|spindle assembly checkpoint	acrosomal vesicle|condensed chromosome kinetochore|cytosol|nucleoplasm	protein binding			breast(3)|central_nervous_system(1)|skin(1)	5		all_cancers(109;2.03e-18)|all_epithelial(112;4.26e-15)|Lung NSC(122;1.12e-10)|all_lung(180;2.59e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.0946)		GBM - Glioblastoma multiforme(113;4.99e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0861)|COAD - Colon adenocarcinoma(120;0.211)		TAAAGTGCCACTGGAGAACAA	0.328		NA											17	84					0	0	0	0
ABHD2	11057	broad.mit.edu	37	15	89698752	89698752	+	Silent	SNP	C	C	T			TCGA-CV-7236-01A-11D-2012-08	TCGA-CV-7236-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dc220a9d-1f16-4fe3-8196-d837a909f038	360144da-2c0b-4e18-81b5-5dde9d7a3682	g.chr15:89698752C>T	uc002bnj.2	+	10	1442	c.525C>T	c.(523-525)CGC>CGT	p.R175R	ABHD2_uc002bnk.2_Silent_p.R175R	NM_007011	NP_008942	P08910	ABHD2_HUMAN	alpha/beta hydrolase domain containing protein	175						integral to membrane	carboxylesterase activity			ovary(1)|lung(1)	2	Lung NSC(78;0.0472)|all_lung(78;0.089)					CCTCGCCACGCATGTTCACCT	0.483		NA											27	96					0	0	0	0
TP53	7157	broad.mit.edu	37	17	7578503	7578503	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7236-01A-11D-2012-08	TCGA-CV-7236-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dc220a9d-1f16-4fe3-8196-d837a909f038	360144da-2c0b-4e18-81b5-5dde9d7a3682	g.chr17:7578503C>T	uc002gim.2	-	5	621	c.427G>A	c.(427-429)GTG>ATG	p.V143M	TP53_uc002gig.1_Missense_Mutation_p.V143M|TP53_uc002gih.2_Missense_Mutation_p.V143M|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.V11M|TP53_uc010cng.1_Missense_Mutation_p.V11M|TP53_uc002gii.1_Missense_Mutation_p.V11M|TP53_uc010cnh.1_Missense_Mutation_p.V143M|TP53_uc010cni.1_Missense_Mutation_p.V143M|TP53_uc002gij.2_Missense_Mutation_p.V143M|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.V50M|TP53_uc002gio.2_Missense_Mutation_p.V11M|TP53_uc010vug.1_Missense_Mutation_p.V104M	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	143	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		V -> G (in sporadic cancers; somatic mutation).|V -> A (in sporadic cancers; somatic mutation; strong DNA binding ability at 32.5 degrees Celsius; strong reduction of transcriptional activity at 37.5 degrees Celsius).|V -> E (in sporadic cancers; somatic mutation).|V -> M (in sporadic cancers; somatic mutation).|V -> L (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.V143M(16)|p.V143A(14)|p.0?(7)|p.V143E(4)|p.V143L(4)|p.V143V(2)|p.V143fs*27(2)|p.L137_W146del10(1)|p.V143fs*29(1)|p.P142_Q144delPVQ(1)|p.K139fs*4(1)|p.A138_V143delAKTCPV(1)|p.V143G(1)|p.V143_S149del(1)|p.C141fs*5(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CACAGCTGCACAGGGCAGGTC	0.587		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			10	46					0	0	0	0
TBC1D3B	414059	broad.mit.edu	37	17	34497333	34497333	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7236-01A-11D-2012-08	TCGA-CV-7236-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dc220a9d-1f16-4fe3-8196-d837a909f038	360144da-2c0b-4e18-81b5-5dde9d7a3682	g.chr17:34497333C>T	uc002hky.2	-	9	733	c.583G>A	c.(583-585)GCC>ACC	p.A195T	uc002khr.2_5'Flank|uc002hlc.2_5'Flank	NM_001001417	NP_001001417	Q8IZP1	TBC3A_HUMAN	TBC1 domain family, member 3B	195	Rab-GAP TBC.					intracellular	Rab GTPase activator activity				0		Breast(25;0.102)|Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		AGGAACAAGGCGGCGATGTGG	0.602		NA											12	191					0	0	0	0
GRIN2C	2905	broad.mit.edu	37	17	72851194	72851194	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7236-01A-11D-2012-08	TCGA-CV-7236-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dc220a9d-1f16-4fe3-8196-d837a909f038	360144da-2c0b-4e18-81b5-5dde9d7a3682	g.chr17:72851194G>A	uc002jlt.1	-	2	194	c.38C>T	c.(37-39)TCG>TTG	p.S13L	GRIN2C_uc010wrh.1_RNA|GRIN2C_uc002jlu.1_Missense_Mutation_p.S13L|GRIN2C_uc002jlv.1_Missense_Mutation_p.S13L	NM_000835	NP_000826	Q14957	NMDE3_HUMAN	N-methyl-D-aspartate receptor subunit 2C	13					glutamate signaling pathway	cell junction|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|N-methyl-D-aspartate selective glutamate receptor activity			ovary(2)|breast(2)	4	all_lung(278;0.172)|Lung NSC(278;0.207)				Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)	ACCGAAGAGCGAGGTGAGCAA	0.682		NA											12	35					0	0	0	0
NETO1	81832	broad.mit.edu	37	18	70532113	70532113	+	Silent	SNP	T	T	C			TCGA-CV-7236-01A-11D-2012-08	TCGA-CV-7236-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dc220a9d-1f16-4fe3-8196-d837a909f038	360144da-2c0b-4e18-81b5-5dde9d7a3682	g.chr18:70532113T>C	uc002lkw.2	-	3	434	c.150A>G	c.(148-150)GGA>GGG	p.G50G	NETO1_uc002lkx.1_Silent_p.G49G|NETO1_uc002lky.1_Silent_p.G50G|NETO1_uc002lkz.2_Silent_p.G49G	NM_138966	NP_620416	Q8TDF5	NETO1_HUMAN	neuropilin- and tolloid-like protein 1 isoform 3	50	CUB 1.|Extracellular (Potential).				memory|regulation of long-term neuronal synaptic plasticity|visual learning	cell junction|excitatory synapse|extracellular region|integral to membrane|postsynaptic density|postsynaptic membrane	receptor activity			ovary(2)|skin(2)	4		Esophageal squamous(42;0.129)		READ - Rectum adenocarcinoma(1;0.0487)		TAAAGATACCTCCCTCTGCAT	0.423		NA											8	40					0	0	0	0
MED16	10025	broad.mit.edu	37	19	873494	873494	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7236-01A-11D-2012-08	TCGA-CV-7236-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dc220a9d-1f16-4fe3-8196-d837a909f038	360144da-2c0b-4e18-81b5-5dde9d7a3682	g.chr19:873494C>G	uc002lqd.1	-	11	2011	c.1860G>C	c.(1858-1860)TGG>TGC	p.W620C	MED16_uc010drw.1_Missense_Mutation_p.W445C|MED16_uc002lqe.2_Missense_Mutation_p.W609C|MED16_uc002lqf.2_Missense_Mutation_p.W609C|MED16_uc010xfv.1_RNA|MED16_uc010xfw.1_Missense_Mutation_p.W540C|MED16_uc010xfx.1_Missense_Mutation_p.W465C|MED16_uc010xfy.1_Missense_Mutation_p.W197C	NM_005481	NP_005472	Q9Y2X0	MED16_HUMAN	mediator complex subunit 16	620					androgen receptor signaling pathway|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	receptor activity|thyroid hormone receptor binding|thyroid hormone receptor coactivator activity|vitamin D receptor binding				0		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;6.59e-06)|all_lung(49;9.97e-06)|Breast(49;9.42e-05)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		AGTCGCCCACCCACTGCAAGA	0.597		NA											4	84					0	0	0	0
BEST2	54831	broad.mit.edu	37	19	12866479	12866479	+	Silent	SNP	C	C	T			TCGA-CV-7236-01A-11D-2012-08	TCGA-CV-7236-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dc220a9d-1f16-4fe3-8196-d837a909f038	360144da-2c0b-4e18-81b5-5dde9d7a3682	g.chr19:12866479C>T	uc002mux.2	+	6	765	c.765C>T	c.(763-765)CGC>CGT	p.R255R		NM_017682	NP_060152	Q8NFU1	BEST2_HUMAN	vitelliform macular dystrophy 2-like 1	255	Extracellular (Potential).				membrane depolarization|sensory perception of smell	chloride channel complex|cilium|plasma membrane	chloride channel activity			ovary(1)|pancreas(1)	2						TCATTGGTCGCCAGTTCCTGG	0.607		NA											16	88					0	0	0	0
MEGF8	1954	broad.mit.edu	37	19	42847639	42847639	+	Silent	SNP	G	G	A			TCGA-CV-7236-01A-11D-2012-08	TCGA-CV-7236-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dc220a9d-1f16-4fe3-8196-d837a909f038	360144da-2c0b-4e18-81b5-5dde9d7a3682	g.chr19:42847639G>A	uc002otl.3	+	9	2159	c.1524G>A	c.(1522-1524)GCG>GCA	p.A508A	MEGF8_uc002otm.3_Silent_p.A49A	NM_001410	NP_001401	Q7Z7M0	MEGF8_HUMAN	multiple EGF-like-domains 8	508	Extracellular (Potential).|Kelch 5.					integral to membrane	calcium ion binding|structural molecule activity			ovary(1)	1		Prostate(69;0.00682)				GCCGAGCAGCGCCTCCCAGTG	0.642		NA											7	59					0	0	0	0
LIPE	3991	broad.mit.edu	37	19	42914528	42914528	+	Silent	SNP	G	G	C	rs151324837	byFrequency	TCGA-CV-7236-01A-11D-2012-08	TCGA-CV-7236-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dc220a9d-1f16-4fe3-8196-d837a909f038	360144da-2c0b-4e18-81b5-5dde9d7a3682	g.chr19:42914528G>C	uc002otr.2	-	2	1627	c.1350C>G	c.(1348-1350)ACC>ACG	p.T450T	uc010eif.1_Intron|LIPE_uc002ots.1_Silent_p.T195T	NM_005357	NP_005348	Q05469	LIPS_HUMAN	hormone-sensitive lipase	450					cholesterol metabolic process|protein phosphorylation|triglyceride catabolic process	caveola|cytosol	hormone-sensitive lipase activity|protein binding			ovary(1)|breast(1)	2		Prostate(69;0.00682)				GGAAGTCGGCGGTGAGCCCCT	0.667		NA											3	26					0	0	0	0
MARK4	57787	broad.mit.edu	37	19	45762439	45762439	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7236-01A-11D-2012-08	TCGA-CV-7236-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dc220a9d-1f16-4fe3-8196-d837a909f038	360144da-2c0b-4e18-81b5-5dde9d7a3682	g.chr19:45762439G>A	uc002pbb.1	+	2	249	c.244G>A	c.(244-246)GGT>AGT	p.G82S	MARK4_uc002paz.1_Intron|MARK4_uc002pba.1_Missense_Mutation_p.G82S			Q96L34	MARK4_HUMAN	RecName: Full=MAP/microtubule affinity-regulating kinase 4;          EC=2.7.11.1; AltName: Full=MAP/microtubule affinity-regulating kinase-like 1;	82	Protein kinase.				microtubule bundle formation|nervous system development|positive regulation of programmed cell death	centrosome|neuron projection	ATP binding|gamma-tubulin binding|microtubule binding|protein serine/threonine kinase activity|tau-protein kinase activity|ubiquitin binding			central_nervous_system(2)|large_intestine(1)	3		all_neural(266;0.224)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.0102)		CATCCTCACTGGTCGGGAGGT	0.617		NA											3	27					0	0	0	0
MYH14	79784	broad.mit.edu	37	19	50805052	50805052	+	Silent	SNP	C	C	T			TCGA-CV-7236-01A-11D-2012-08	TCGA-CV-7236-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dc220a9d-1f16-4fe3-8196-d837a909f038	360144da-2c0b-4e18-81b5-5dde9d7a3682	g.chr19:50805052C>T	uc002prr.1	+	38	5528	c.5481C>T	c.(5479-5481)GCC>GCT	p.A1827A	MYH14_uc010enu.1_Silent_p.A1868A|MYH14_uc002prq.1_Silent_p.A1835A|MYH14_uc010ycb.1_Silent_p.A178A|MYH14_uc002prs.1_Silent_p.A178A	NM_024729	NP_079005	Q7Z406	MYH14_HUMAN	myosin, heavy chain 14 isoform 2	1827	Potential.				axon guidance|regulation of cell shape	myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			central_nervous_system(1)	1		all_neural(266;0.0571)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.00389)|GBM - Glioblastoma multiforme(134;0.0195)		GGGCCCGTGCCCGCCACAAGA	0.637		NA											6	33					0	0	0	0
C19orf51	352909	broad.mit.edu	37	19	55670685	55670685	+	Silent	SNP	G	G	A			TCGA-CV-7236-01A-11D-2012-08	TCGA-CV-7236-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dc220a9d-1f16-4fe3-8196-d837a909f038	360144da-2c0b-4e18-81b5-5dde9d7a3682	g.chr19:55670685G>A	uc002qji.1	-	12	1405	c.1371C>T	c.(1369-1371)TCC>TCT	p.S457S	TNNI3_uc002qjg.3_5'Flank|TNNI3_uc010yft.1_5'Flank|C19orf51_uc002qjh.1_Silent_p.S272S|C19orf51_uc002qjj.1_Silent_p.S504S|C19orf51_uc002qjk.1_Silent_p.S403S|C19orf51_uc002qjl.1_Silent_p.S524S			Q8N9W5	CS051_HUMAN	RecName: Full=UPF0470 protein C19orf51;	457											0			BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.044)		CTGATTCCTGGGACTTGCAGA	0.612		NA											9	51					0	0	0	0
BAZ2B	29994	broad.mit.edu	37	2	160206265	160206265	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7236-01A-11D-2012-08	TCGA-CV-7236-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dc220a9d-1f16-4fe3-8196-d837a909f038	360144da-2c0b-4e18-81b5-5dde9d7a3682	g.chr2:160206265G>A	uc002uao.2	-	28	5169	c.4817C>T	c.(4816-4818)GCT>GTT	p.A1606V	BAZ2B_uc002uap.2_Missense_Mutation_p.A1570V	NM_013450	NP_038478	Q9UIF8	BAZ2B_HUMAN	bromodomain adjacent to zinc finger domain, 2B	1606					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(3)|skin(1)	4						AGGATTCTGAGCAGAAGATCC	0.423		NA											3	62					0	0	0	0
EVX2	344191	broad.mit.edu	37	2	176947144	176947144	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7236-01A-11D-2012-08	TCGA-CV-7236-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dc220a9d-1f16-4fe3-8196-d837a909f038	360144da-2c0b-4e18-81b5-5dde9d7a3682	g.chr2:176947144G>A	uc010zeu.1	-	2	647	c.461C>T	c.(460-462)ACG>ATG	p.T154M		NM_001080458	NP_001073927	Q03828	EVX2_HUMAN	even-skipped homeobox 2	154						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(117;0.0207)|Epithelial(96;0.18)	READ - Rectum adenocarcinoma(9;0.0678)|Colorectal(32;0.115)		CGCCGACGTCGTGGTGCCGGC	0.711		NA											4	30					0	0	0	0
TTN	7273	broad.mit.edu	37	2	179411521	179411521	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7236-01A-11D-2012-08	TCGA-CV-7236-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dc220a9d-1f16-4fe3-8196-d837a909f038	360144da-2c0b-4e18-81b5-5dde9d7a3682	g.chr2:179411521C>T	uc010zfg.1	-	290	87154	c.86930G>A	c.(86929-86931)CGT>CAT	p.R28977H	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.R22672H|TTN_uc010zfi.1_Missense_Mutation_p.R22605H|TTN_uc010zfj.1_Missense_Mutation_p.R22480H	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	29904							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GACTGGCTTACGCTCTATGAT	0.498		NA											12	59					0	0	0	0
DNMT3B	1789	broad.mit.edu	37	20	31385069	31385069	+	Missense_Mutation	SNP	G	G	T			TCGA-CV-7236-01A-11D-2012-08	TCGA-CV-7236-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dc220a9d-1f16-4fe3-8196-d837a909f038	360144da-2c0b-4e18-81b5-5dde9d7a3682	g.chr20:31385069G>T	uc002wyc.2	+	14	1775	c.1454G>T	c.(1453-1455)CGA>CTA	p.R485L	DNMT3B_uc010ztx.1_RNA|DNMT3B_uc010zty.1_RNA|DNMT3B_uc002wyd.2_Missense_Mutation_p.R465L|DNMT3B_uc002wye.2_Missense_Mutation_p.R465L|DNMT3B_uc010gee.2_RNA|DNMT3B_uc010gef.2_RNA|DNMT3B_uc010ztz.1_Missense_Mutation_p.R423L|DNMT3B_uc010zua.1_Missense_Mutation_p.R389L|DNMT3B_uc002wyf.2_Missense_Mutation_p.R477L|DNMT3B_uc002wyg.2_Missense_Mutation_p.R184L	NM_006892	NP_008823	Q9UBC3	DNM3B_HUMAN	DNA cytosine-5 methyltransferase 3 beta isoform	485	PHD-type; atypical.|Interaction with the PRC2/EED-EZH2 complex (By similarity).|ADD.				negative regulation of histone H3-K9 methylation|positive regulation of gene expression|positive regulation of histone H3-K4 methylation		metal ion binding|protein binding|transcription corepressor activity			lung(3)|ovary(2)	5						TGCGAGGGCCGAGAGCTGCTG	0.587		NA											16	117					1.36e-06	1.68e-06	1	0
ZMYND8	23613	broad.mit.edu	37	20	45839455	45839455	+	Missense_Mutation	SNP	G	G	A	rs146133202		TCGA-CV-7236-01A-11D-2012-08	TCGA-CV-7236-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dc220a9d-1f16-4fe3-8196-d837a909f038	360144da-2c0b-4e18-81b5-5dde9d7a3682	g.chr20:45839455G>A	uc002xta.1	-	22	3766	c.3512C>T	c.(3511-3513)ACG>ATG	p.T1171M	ZMYND8_uc010ghq.1_Nonsense_Mutation_p.R808*|ZMYND8_uc010ghr.1_Missense_Mutation_p.T1101M|ZMYND8_uc002xst.1_Missense_Mutation_p.T1053M|ZMYND8_uc002xsu.1_Missense_Mutation_p.T1072M|ZMYND8_uc002xsv.1_Missense_Mutation_p.T1099M|ZMYND8_uc002xsw.1_Missense_Mutation_p.T905M|ZMYND8_uc002xsx.1_Missense_Mutation_p.T877M|ZMYND8_uc002xsy.1_Missense_Mutation_p.T1128M|ZMYND8_uc002xsz.1_Missense_Mutation_p.T1090M|ZMYND8_uc010zxy.1_Missense_Mutation_p.T1226M|ZMYND8_uc002xtb.1_Missense_Mutation_p.T1173M|ZMYND8_uc002xss.2_Missense_Mutation_p.T1171M|ZMYND8_uc010zxz.1_Missense_Mutation_p.T1039M|ZMYND8_uc002xtc.1_Missense_Mutation_p.T1145M|ZMYND8_uc002xtd.1_Missense_Mutation_p.T1120M|ZMYND8_uc002xte.1_Missense_Mutation_p.T1153M|ZMYND8_uc010zya.1_Missense_Mutation_p.T1199M|ZMYND8_uc002xtf.1_Missense_Mutation_p.T1219M|ZMYND8_uc002xsr.1_Missense_Mutation_p.T270M	NM_012408	NP_036540	Q9ULU4	PKCB1_HUMAN	zinc finger, MYND-type containing 8 isoform b	1171	Interacts with PRKCB1.						protein binding|zinc ion binding			central_nervous_system(2)|urinary_tract(1)|ovary(1)|skin(1)	5			Epithelial(1;0.0289)|all cancers(1;0.0962)|OV - Ovarian serous cystadenocarcinoma(1;0.154)			GAGGCTCTTCGTGCTGGTACT	0.542		NA											10	89					0	0	0	0
HIC2	23119	broad.mit.edu	37	22	21799898	21799898	+	Silent	SNP	C	C	T			TCGA-CV-7236-01A-11D-2012-08	TCGA-CV-7236-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dc220a9d-1f16-4fe3-8196-d837a909f038	360144da-2c0b-4e18-81b5-5dde9d7a3682	g.chr22:21799898C>T	uc002zur.3	+	3	944	c.714C>T	c.(712-714)AGC>AGT	p.S238S	HIC2_uc002zus.3_Silent_p.S238S	NM_015094	NP_055909	Q96JB3	HIC2_HUMAN	hypermethylated in cancer 2	238					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	focal adhesion|nucleus	DNA binding|protein C-terminus binding|zinc ion binding			skin(1)	1	Melanoma(16;0.000465)|Ovarian(15;0.00438)|Colorectal(54;0.0968)	Lung SC(17;0.0262)|all_lung(157;0.205)				ACGGGAGCAGCGGGGGCTGCG	0.697		NA											6	34					0	0	0	0
C22orf36	388886	broad.mit.edu	37	22	24982181	24982181	+	Silent	SNP	C	C	T	rs111248278		TCGA-CV-7236-01A-11D-2012-08	TCGA-CV-7236-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dc220a9d-1f16-4fe3-8196-d837a909f038	360144da-2c0b-4e18-81b5-5dde9d7a3682	g.chr22:24982181C>T	uc003aaq.2	-	4	650	c.621G>A	c.(619-621)CTG>CTA	p.L207L	GGT1_uc003aan.1_Intron|C22orf36_uc003aao.2_RNA|C22orf36_uc003aap.2_RNA	NM_207644	NP_997527	Q2VPJ9	LRC6X_HUMAN	hypothetical protein LOC388886	207	LRR 2.										0						TGAGGCGGGGCAGCGCCCACA	0.652		NA											27	95					0	0	0	0
CHL1	10752	broad.mit.edu	37	3	369940	369940	+	Silent	SNP	C	C	T			TCGA-CV-7236-01A-11D-2012-08	TCGA-CV-7236-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dc220a9d-1f16-4fe3-8196-d837a909f038	360144da-2c0b-4e18-81b5-5dde9d7a3682	g.chr3:369940C>T	uc003bou.2	+	5	559	c.288C>T	c.(286-288)AAC>AAT	p.N96N	CHL1_uc003bot.2_Silent_p.N96N|CHL1_uc003bow.1_Silent_p.N96N|CHL1_uc011asi.1_Silent_p.N96N	NM_006614	NP_006605	O00533	CHL1_HUMAN	cell adhesion molecule with homology to L1CAM	96	Ig-like C2-type 1.|Extracellular (Potential).				axon guidance|cell adhesion|signal transduction	integral to membrane|plasma membrane|proteinaceous extracellular matrix				skin(5)|central_nervous_system(4)|large_intestine(2)|ovary(1)	12		all_cancers(2;1.14e-06)|all_epithelial(2;0.00367)|all_lung(1;0.061)|Lung NSC(2;0.201)		Epithelial(13;5.36e-06)|all cancers(10;1.4e-05)|OV - Ovarian serous cystadenocarcinoma(96;0.00323)|COAD - Colon adenocarcinoma(1;0.00925)|Colorectal(20;0.0198)		GGATCCCAAACGAGGGGCACA	0.388		NA											14	80					0	0	0	0
FGD5	152273	broad.mit.edu	37	3	14942543	14942543	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7236-01A-11D-2012-08	TCGA-CV-7236-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dc220a9d-1f16-4fe3-8196-d837a909f038	360144da-2c0b-4e18-81b5-5dde9d7a3682	g.chr3:14942543G>A	uc003bzc.2	+	9	3349	c.3239G>A	c.(3238-3240)CGT>CAT	p.R1080H	FGD5_uc011avk.1_Missense_Mutation_p.R1080H|FGD5_uc003bzd.2_Missense_Mutation_p.R158H	NM_152536	NP_689749	Q6ZNL6	FGD5_HUMAN	FYVE, RhoGEF and PH domain containing 5	1080	DH.				actin cytoskeleton organization|filopodium assembly|regulation of Cdc42 GTPase activity|regulation of cell shape	cytoskeleton|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			ovary(3)|kidney(1)|pancreas(1)	5						GTCACAGACCGTGCCAACGAC	0.607		NA											22	101					0	0	0	0
WDR49	151790	broad.mit.edu	37	3	167240197	167240197	+	Nonsense_Mutation	SNP	T	T	A			TCGA-CV-7236-01A-11D-2012-08	TCGA-CV-7236-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dc220a9d-1f16-4fe3-8196-d837a909f038	360144da-2c0b-4e18-81b5-5dde9d7a3682	g.chr3:167240197T>A	uc003fev.1	-	12	1930	c.1624A>T	c.(1624-1626)AAG>TAG	p.K542*	WDR49_uc003feu.1_Nonsense_Mutation_p.K367*|WDR49_uc011bpd.1_Intron|WDR49_uc003few.1_Intron	NM_178824	NP_849146	Q8IV35	WDR49_HUMAN	WD repeat domain 49	542										large_intestine(1)|ovary(1)|skin(1)	3						GAAATTTCCTTTTGAATCTCA	0.318		NA											21	40					0	0	0	0
ENPEP	2028	broad.mit.edu	37	4	111398075	111398075	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7236-01A-11D-2012-08	TCGA-CV-7236-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dc220a9d-1f16-4fe3-8196-d837a909f038	360144da-2c0b-4e18-81b5-5dde9d7a3682	g.chr4:111398075G>A	uc003iab.3	+	1	847	c.505G>A	c.(505-507)GTG>ATG	p.V169M		NM_001977	NP_001968	Q07075	AMPE_HUMAN	glutamyl aminopeptidase	169	Extracellular (Potential).				cell migration|cell proliferation|cell-cell signaling|proteolysis	integral to plasma membrane	aminopeptidase activity|metalloexopeptidase activity|zinc ion binding			skin(3)|ovary(1)|breast(1)	5		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.0031)	L-Glutamic Acid(DB00142)	GCAGGAGTACGTGGTGGTCGA	0.632		NA											31	165					0	0	0	0
RAPGEF2	9693	broad.mit.edu	37	4	160251524	160251524	+	Silent	SNP	G	G	A			TCGA-CV-7236-01A-11D-2012-08	TCGA-CV-7236-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dc220a9d-1f16-4fe3-8196-d837a909f038	360144da-2c0b-4e18-81b5-5dde9d7a3682	g.chr4:160251524G>A	uc003iqg.3	+	7	1168	c.858G>A	c.(856-858)GAG>GAA	p.E286E		NM_014247	NP_055062	Q9Y4G8	RPGF2_HUMAN	Rap guanine nucleotide exchange factor 2	286	N-terminal Ras-GEF.				cAMP-mediated signaling|MAPKKK cascade|small GTPase mediated signal transduction	integral to plasma membrane|intracellular	calcium ion binding|diacylglycerol binding|Rap GTPase activator activity|Rap guanyl-nucleotide exchange factor activity|signal transducer activity			lung(2)|upper_aerodigestive_tract(1)|skin(1)	4	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.0817)		TGGTGGAAGAGCATTCAGTAG	0.313		NA											17	88					0	0	0	0
HAND2	9464	broad.mit.edu	37	4	174449919	174449919	+	Silent	SNP	G	G	A			TCGA-CV-7236-01A-11D-2012-08	TCGA-CV-7236-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dc220a9d-1f16-4fe3-8196-d837a909f038	360144da-2c0b-4e18-81b5-5dde9d7a3682	g.chr4:174449919G>A	uc003ith.1	-	1	1460	c.522C>T	c.(520-522)ACC>ACT	p.T174T	NBLA00301_uc011ckd.1_5'Flank|NBLA00301_uc003itl.3_5'Flank|NBLA00301_uc003itj.2_5'Flank|NBLA00301_uc010irf.2_5'Flank|NBLA00301_uc010irg.2_5'Flank|NBLA00301_uc010irh.2_5'Flank|NBLA00301_uc010iri.2_5'Flank|NBLA00301_uc010irj.2_5'Flank|NBLA00301_uc010irk.2_5'Flank|NBLA00301_uc010irl.2_5'Flank|NBLA00301_uc010irm.2_5'Flank|NBLA00301_uc010irn.2_5'Flank|NBLA00301_uc003itk.2_5'Flank|HAND2_uc003itg.1_Nonsense_Mutation_p.R140*|HAND2_uc010ire.1_Silent_p.T174T	NM_021973	NP_068808	P61296	HAND2_HUMAN	basic helix-loop-helix transcription factor	174					adult heart development|angiogenesis|apoptosis|cardiac neural crest cell development involved in outflow tract morphogenesis|heart looping|in utero embryonic development|negative regulation of cardiac muscle cell apoptosis|noradrenergic neuron differentiation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription regulatory region DNA binding|regulation of secondary heart field cardioblast proliferation|thymus development	nuclear chromatin|transcription factor complex	activating transcription factor binding|protein homodimerization activity|RNA polymerase II regulatory region sequence-specific DNA binding|transcription coactivator activity			skin(1)	1		Prostate(90;0.00601)|Renal(120;0.0183)|Melanoma(52;0.0749)|all_neural(102;0.0837)|all_hematologic(60;0.107)		all cancers(43;1.37e-18)|Epithelial(43;5.5e-17)|OV - Ovarian serous cystadenocarcinoma(60;3.3e-10)|STAD - Stomach adenocarcinoma(60;0.00273)|GBM - Glioblastoma multiforme(59;0.0064)|LUSC - Lung squamous cell carcinoma(193;0.0903)|Kidney(143;0.249)		CTTTCACGTCGGTCTTCTTGA	0.627		NA											14	34					0	0	0	0
HIST1H2BK	85236	broad.mit.edu	37	6	27114571	27114571	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7236-01A-11D-2012-08	TCGA-CV-7236-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dc220a9d-1f16-4fe3-8196-d837a909f038	360144da-2c0b-4e18-81b5-5dde9d7a3682	g.chr6:27114571C>T	uc003nix.1	-	1	49	c.7G>A	c.(7-9)GAA>AAA	p.E3K	HIST1H2AH_uc003niz.2_5'Flank|hsa-mir-3143|MI0014167_5'Flank	NM_080593	NP_542160	O60814	H2B1K_HUMAN	histone cluster 1, H2bk	3					defense response to bacterium|nucleosome assembly	nucleosome|nucleus	DNA binding				0						TTCGCTGGTTCCGGCATGTTG	0.567		NA											8	84					0	0	0	0
EPDR1	54749	broad.mit.edu	37	7	37988614	37988614	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7236-01A-11D-2012-08	TCGA-CV-7236-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dc220a9d-1f16-4fe3-8196-d837a909f038	360144da-2c0b-4e18-81b5-5dde9d7a3682	g.chr7:37988614G>A	uc003tfp.2	+	2	821	c.802G>A	c.(802-804)GTC>ATC	p.V268I	EPDR1_uc003tfq.2_Intron|EPDR1_uc010kxh.2_Missense_Mutation_p.V87I	NM_017549	NP_060019	Q9UM22	EPDR1_HUMAN	ependymin related protein 1 precursor	148					cell-matrix adhesion	extracellular region	calcium ion binding			upper_aerodigestive_tract(1)	1						GCAGATCACCGTCCAGGAGTG	0.493		NA											7	85					0	0	0	0
POM121	9883	broad.mit.edu	37	7	72418901	72418901	+	Silent	SNP	G	G	A			TCGA-CV-7236-01A-11D-2012-08	TCGA-CV-7236-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dc220a9d-1f16-4fe3-8196-d837a909f038	360144da-2c0b-4e18-81b5-5dde9d7a3682	g.chr7:72418901G>A	uc010lam.1	+	16	3933	c.2892G>A	c.(2890-2892)CCG>CCA	p.P964P	NSUN5P2_uc003twl.2_RNA|NSUN5P2_uc003twm.2_3'UTR|NSUN5P2_uc003twn.2_3'UTR|NSUN5P2_uc003two.2_3'UTR|NSUN5P2_uc003twq.2_3'UTR|NSUN5P2_uc010lan.1_3'UTR|NSUN5P2_uc003twp.2_3'UTR	NM_172020	NP_742017	Q96HA1	P121A_HUMAN	nuclear pore membrane protein 121	1003	Pore side (Potential).				carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	endoplasmic reticulum membrane|nuclear membrane|nuclear pore					0		Lung NSC(55;0.163)				AACACAGCCCGAGGAAGGGAC	0.488		NA											14	85					0	0	0	0
ZNF777	27153	broad.mit.edu	37	7	149152729	149152729	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7236-01A-11D-2012-08	TCGA-CV-7236-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dc220a9d-1f16-4fe3-8196-d837a909f038	360144da-2c0b-4e18-81b5-5dde9d7a3682	g.chr7:149152729C>T	uc003wfv.2	-	2	548	c.385G>A	c.(385-387)GTT>ATT	p.V129I		NM_015694	NP_056509	Q9ULD5	ZN777_HUMAN	zinc finger protein 777	129					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1	Melanoma(164;0.165)		OV - Ovarian serous cystadenocarcinoma(82;0.00358)			GGGGAGTGAACGGGGGCTTCC	0.617		NA											23	174					0	0	0	0
ZNF775	285971	broad.mit.edu	37	7	150094922	150094922	+	Silent	SNP	C	C	T			TCGA-CV-7236-01A-11D-2012-08	TCGA-CV-7236-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dc220a9d-1f16-4fe3-8196-d837a909f038	360144da-2c0b-4e18-81b5-5dde9d7a3682	g.chr7:150094922C>T	uc003whf.1	+	3	1478	c.1353C>T	c.(1351-1353)TGC>TGT	p.C451C	LOC728743_uc003whg.2_5'Flank	NM_173680	NP_775951	Q96BV0	ZN775_HUMAN	zinc finger protein 775	451	C2H2-type 9.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	Ovarian(565;0.183)|Melanoma(164;0.226)		OV - Ovarian serous cystadenocarcinoma(82;0.0173)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		GCAACGAGTGCGGCAAGAGCT	0.731		NA											5	14					0	0	0	0
SLCO5A1	81796	broad.mit.edu	37	8	70585202	70585202	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7236-01A-11D-2012-08	TCGA-CV-7236-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dc220a9d-1f16-4fe3-8196-d837a909f038	360144da-2c0b-4e18-81b5-5dde9d7a3682	g.chr8:70585202C>T	uc003xyl.2	-	10	3156	c.2449G>A	c.(2449-2451)GCA>ACA	p.A817T	SLCO5A1_uc010lzb.2_Missense_Mutation_p.A762T|SLCO5A1_uc011lfa.1_RNA|SLCO5A1_uc003xyk.2_3'UTR	NM_030958	NP_112220	Q9H2Y9	SO5A1_HUMAN	solute carrier organic anion transporter family,	817						integral to membrane|plasma membrane	transporter activity			ovary(3)|upper_aerodigestive_tract(1)	4	Breast(64;0.0654)		Epithelial(68;0.0141)|OV - Ovarian serous cystadenocarcinoma(28;0.0315)|all cancers(69;0.0594)			GTCTGTGCTGCGCACTGGATC	0.617		NA											11	79					0	0	0	0
HNF4G	3174	broad.mit.edu	37	8	76471035	76471035	+	Splice_Site	SNP	G	G	A			TCGA-CV-7236-01A-11D-2012-08	TCGA-CV-7236-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dc220a9d-1f16-4fe3-8196-d837a909f038	360144da-2c0b-4e18-81b5-5dde9d7a3682	g.chr8:76471035G>A	uc003yaq.2	+	9	1016	c.746_splice	c.e9-1	p.D249_splice	HNF4G_uc003yar.2_Splice_Site_p.D286_splice	NM_004133	NP_004124	Q14541	HNF4G_HUMAN	hepatocyte nuclear factor 4, gamma						endocrine pancreas development|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			ovary(1)	1	Breast(64;0.0448)		BRCA - Breast invasive adenocarcinoma(89;0.161)			TCCTTTGTTAGATGCAAAAGG	0.353		NA											13	28					0	0	0	0
PLEC	5339	broad.mit.edu	37	8	144993755	144993755	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7236-01A-11D-2012-08	TCGA-CV-7236-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dc220a9d-1f16-4fe3-8196-d837a909f038	360144da-2c0b-4e18-81b5-5dde9d7a3682	g.chr8:144993755C>T	uc003zaf.1	-	32	10815	c.10645G>A	c.(10645-10647)GCC>ACC	p.A3549T	PLEC_uc003zab.1_Missense_Mutation_p.A3412T|PLEC_uc003zac.1_Missense_Mutation_p.A3416T|PLEC_uc003zad.2_Missense_Mutation_p.A3412T|PLEC_uc003zae.1_Missense_Mutation_p.A3380T|PLEC_uc003zag.1_Missense_Mutation_p.A3390T|PLEC_uc003zah.2_Missense_Mutation_p.A3398T|PLEC_uc003zaj.2_Missense_Mutation_p.A3439T	NM_201380	NP_958782	Q15149	PLEC_HUMAN	plectin isoform 1	3549	Plectin 13.|Globular 2.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle|structural constituent of muscle			large_intestine(2)|ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	9						GCCTTCACGGCCTCGTGGACA	0.687		NA											13	38					0	0	0	0
ZNF510	22869	broad.mit.edu	37	9	99521423	99521423	+	Silent	SNP	C	C	T			TCGA-CV-7236-01A-11D-2012-08	TCGA-CV-7236-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dc220a9d-1f16-4fe3-8196-d837a909f038	360144da-2c0b-4e18-81b5-5dde9d7a3682	g.chr9:99521423C>T	uc004awn.1	-	6	1878	c.1689G>A	c.(1687-1689)CAG>CAA	p.Q563Q	ZNF510_uc004awo.1_Silent_p.Q563Q	NM_014930	NP_055745	Q9Y2H8	ZN510_HUMAN	zinc finger protein 510	563	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Acute lymphoblastic leukemia(62;0.0527)				TGTGAGTTTTCTGATGTTGAA	0.423		NA											9	120					0	0	0	0
GOLGA2	2801	broad.mit.edu	37	9	131019939	131019939	+	Silent	SNP	G	G	T			TCGA-CV-7236-01A-11D-2012-08	TCGA-CV-7236-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dc220a9d-1f16-4fe3-8196-d837a909f038	360144da-2c0b-4e18-81b5-5dde9d7a3682	g.chr9:131019939G>T	uc011maw.1	-	24	2591	c.2578C>A	c.(2578-2580)CGG>AGG	p.R860R	GOLGA2_uc010mxw.2_Silent_p.R183R|GOLGA2_uc004buh.2_Intron	NM_004486	NP_004477	Q08379	GOGA2_HUMAN	Golgi autoantigen, golgin subfamily a, 2	860	Potential.					Golgi cisterna membrane	protein binding			ovary(1)	1						TCCCGGTGCCGCTCCTTCAGC	0.622		NA											19	202					1.34e-09	1.66e-09	1	0
RAPGEF1	2889	broad.mit.edu	37	9	134458080	134458080	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7236-01A-11D-2012-08	TCGA-CV-7236-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dc220a9d-1f16-4fe3-8196-d837a909f038	360144da-2c0b-4e18-81b5-5dde9d7a3682	g.chr9:134458080C>T	uc004cbc.2	-	22	2996	c.2866G>A	c.(2866-2868)GAG>AAG	p.E956K	RAPGEF1_uc004cbb.2_Missense_Mutation_p.E974K	NM_005312	NP_005303	Q13905	RPGF1_HUMAN	guanine nucleotide-releasing factor 2 isoform a	956	Ras-GEF.				activation of MAPKK activity|nerve growth factor receptor signaling pathway|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|endosome	guanyl-nucleotide exchange factor activity|SH3 domain binding			lung(3)|ovary(2)|breast(1)|skin(1)	7		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;2.19e-05)|Epithelial(140;0.000364)		GTGCAGTACTCGGCCAGGCCC	0.562		NA											19	90					0	0	0	0
NOTCH1	4851	broad.mit.edu	37	9	139412252	139412252	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7236-01A-11D-2012-08	TCGA-CV-7236-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dc220a9d-1f16-4fe3-8196-d837a909f038	360144da-2c0b-4e18-81b5-5dde9d7a3682	g.chr9:139412252C>T	uc004chz.2	-	8	1393	c.1393G>A	c.(1393-1395)GCC>ACC	p.A465T		NM_017617	NP_060087	P46531	NOTC1_HUMAN	notch1 preproprotein	465	Extracellular (Potential).|EGF-like 12; calcium-binding (Potential).				aortic valve morphogenesis|immune response|negative regulation of BMP signaling pathway|negative regulation of cell-substrate adhesion|negative regulation of myoblast differentiation|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-dependent|Notch receptor processing	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			haematopoietic_and_lymphoid_tissue(791)|upper_aerodigestive_tract(29)|lung(13)|central_nervous_system(10)|breast(9)|large_intestine(1)|skin(1)|oesophagus(1)|pancreas(1)	856	all_cancers(76;0.223)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.34e-06)|Epithelial(140;7.77e-06)		AGGCAGGTGGCGTCGTTCTGG	0.672		NA	T|Mis|O	TRB@	T-ALL					HNSCC(8;0.001)			20	74					0	0	0	0
P2RY10	27334	broad.mit.edu	37	X	78217018	78217018	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7236-01A-11D-2012-08	TCGA-CV-7236-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dc220a9d-1f16-4fe3-8196-d837a909f038	360144da-2c0b-4e18-81b5-5dde9d7a3682	g.chrX:78217018G>C	uc004ede.2	+	4	1370	c.1001G>C	c.(1000-1002)GGT>GCT	p.G334A	P2RY10_uc004edf.2_Missense_Mutation_p.G334A	NM_014499	NP_055314	O00398	P2Y10_HUMAN	G-protein coupled purinergic receptor P2Y10	334	Cytoplasmic (Potential).					integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			ovary(2)|lung(2)|breast(1)	5						AAGGAGAGTGGTTCATCAATG	0.418		NA											18	133					0	0	0	0
UBE2J2	118424	broad.mit.edu	37	1	1191442	1191443	+	Frame_Shift_Del	DEL	AT	AT	-			TCGA-CV-7236-01A-11D-2012-08	TCGA-CV-7236-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dc220a9d-1f16-4fe3-8196-d837a909f038	360144da-2c0b-4e18-81b5-5dde9d7a3682	g.chr1:1191442_1191443delAT	uc001adn.2	-	6	787_788	c.477_478delAT	c.(475-480)TTATTTfs	p.L159fs	UBE2J2_uc001adm.2_Frame_Shift_Del_p.L124fs|UBE2J2_uc001ado.2_Frame_Shift_Del_p.L175fs|UBE2J2_uc001adp.2_Frame_Shift_Del_p.L159fs|UBE2J2_uc001adq.2_Frame_Shift_Del_p.L107fs|UBE2J2_uc001adr.2_Frame_Shift_Del_p.L107fs|UBE2J2_uc001ads.2_Frame_Shift_Del_p.L107fs	NM_194458	NP_919440	Q8N2K1	UB2J2_HUMAN	ubiquitin conjugating enzyme E2, J2 isoform 3	159_160	Cytoplasmic (Potential).				response to unfolded protein	endoplasmic reticulum membrane|integral to membrane	ATP binding|ubiquitin-protein ligase activity				0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;6.66e-35)|OV - Ovarian serous cystadenocarcinoma(86;3.53e-21)|Colorectal(212;0.00019)|COAD - Colon adenocarcinoma(227;0.000215)|Kidney(185;0.00255)|BRCA - Breast invasive adenocarcinoma(365;0.00266)|STAD - Stomach adenocarcinoma(132;0.00645)|KIRC - Kidney renal clear cell carcinoma(229;0.0371)|Lung(427;0.205)		ACTTCAGGAAATAATTCACAAA	0.401		NA											16	100	---	---	---	---	NA	NA	NA	NA
ODF2L	57489	broad.mit.edu	37	1	86850380	86850382	+	In_Frame_Del	DEL	AAG	AAG	-			TCGA-CV-7236-01A-11D-2012-08	TCGA-CV-7236-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dc220a9d-1f16-4fe3-8196-d837a909f038	360144da-2c0b-4e18-81b5-5dde9d7a3682	g.chr1:86850380_86850382delAAG	uc001dll.1	-	4	689_691	c.349_351delCTT	c.(349-351)CTTdel	p.L117del	ODF2L_uc001dlm.1_In_Frame_Del_p.L117del|ODF2L_uc001dln.2_In_Frame_Del_p.L117del|ODF2L_uc001dlo.2_5'UTR|ODF2L_uc001dlp.2_In_Frame_Del_p.L117del|ODF2L_uc010osg.1_In_Frame_Del_p.L117del|ODF2L_uc001dlq.1_Intron|ODF2L_uc009wcr.1_Intron	NM_020729	NP_065780	Q9ULJ1	ODF2L_HUMAN	outer dense fiber of sperm tails 2-like isoform	117						centrosome				ovary(1)	1				all cancers(265;0.0313)|Epithelial(280;0.0611)		CTCTCTTTCTAAGAAGATGTTCT	0.286		NA											7	73	---	---	---	---	NA	NA	NA	NA
RASSF8	11228	broad.mit.edu	37	12	26217656	26217656	+	Frame_Shift_Del	DEL	C	C	-			TCGA-CV-7236-01A-11D-2012-08	TCGA-CV-7236-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dc220a9d-1f16-4fe3-8196-d837a909f038	360144da-2c0b-4e18-81b5-5dde9d7a3682	g.chr12:26217656delC	uc001rgx.2	+	3	550	c.329delC	c.(328-330)GCTfs	p.A110fs	RASSF8_uc001rgy.2_Frame_Shift_Del_p.A110fs|RASSF8_uc001rgz.2_Frame_Shift_Del_p.A110fs|RASSF8_uc009zjd.1_Frame_Shift_Del_p.A110fs|RASSF8_uc009zje.1_Frame_Shift_Del_p.A110fs	NM_007211	NP_009142	Q8NHQ8	RASF8_HUMAN	Ras association (RalGDS/AF-6) domain family	110					signal transduction						0	Colorectal(261;0.0847)					CCCCCCTTAGCTAAACTGAGG	0.468		NA											12	122	---	---	---	---	NA	NA	NA	NA
FAM98A	25940	broad.mit.edu	37	2	33820638	33820638	+	Frame_Shift_Del	DEL	G	G	-			TCGA-CV-7236-01A-11D-2012-08	TCGA-CV-7236-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dc220a9d-1f16-4fe3-8196-d837a909f038	360144da-2c0b-4e18-81b5-5dde9d7a3682	g.chr2:33820638delG	uc002rpa.1	-	2	194	c.120delC	c.(118-120)CCCfs	p.P40fs	FAM98A_uc010yne.1_5'UTR	NM_015475	NP_056290	Q8NCA5	FA98A_HUMAN	hypothetical protein LOC25940	40										ovary(1)	1	all_hematologic(175;0.115)					TGGTAAACTCGGGGGAACTGG	0.448		NA											10	105	---	---	---	---	NA	NA	NA	NA
EGFR	1956	broad.mit.edu	37	7	55221819	55221831	+	Frame_Shift_Del	DEL	GTGCCACCTGCGT	GTGCCACCTGCGT	-	rs149840192		TCGA-CV-7236-01A-11D-2012-08	TCGA-CV-7236-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dc220a9d-1f16-4fe3-8196-d837a909f038	360144da-2c0b-4e18-81b5-5dde9d7a3682	g.chr7:55221819_55221831delGTGCCACCTGCGT	uc003tqk.2	+	7	1109_1121	c.863_875delGTGCCACCTGCGT	c.(862-876)GGTGCCACCTGCGTGfs	p.G288fs	EGFR_uc003tqh.2_Frame_Shift_Del_p.G288fs|EGFR_uc003tqi.2_Frame_Shift_Del_p.G288fs|EGFR_uc003tqj.2_Frame_Shift_Del_p.G288fs|EGFR_uc010kzg.1_Frame_Shift_Del_p.G243fs|EGFR_uc011kco.1_Frame_Shift_Del_p.G235fs|EGFR_uc011kcp.1_5'Flank|EGFR_uc011kcq.1_5'Flank	NM_005228	NP_005219	P00533	EGFR_HUMAN	epidermal growth factor receptor isoform a	288_292	Approximate.|Extracellular (Potential).				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.A289V(20)|p.V30_R297>G(5)|p.A289T(3)|p.A289D(3)|p.V292L(1)		lung(9213)|central_nervous_system(103)|stomach(41)|upper_aerodigestive_tract(39)|prostate(32)|ovary(31)|thyroid(24)|breast(11)|peritoneum(9)|oesophagus(9)|salivary_gland(9)|large_intestine(8)|kidney(8)|urinary_tract(6)|skin(5)|adrenal_gland(5)|soft_tissue(4)|bone(3)|NS(2)|pancreas(2)|haematopoietic_and_lymphoid_tissue(2)|thymus(2)|liver(2)|eye(1)	9571	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	TACAGCTTTGGTGCCACCTGCGTGAAGAAGTGT	0.592		8	A|O|Mis		glioma|NSCLC	NSCLC			Lung_Cancer_Familial_Clustering_of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			8	318	---	---	---	---	NA	NA	NA	NA
PKHD1L1	93035	broad.mit.edu	37	8	110455173	110455174	+	Splice_Site	INS	-	-	G			TCGA-CV-7236-01A-11D-2012-08	TCGA-CV-7236-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dc220a9d-1f16-4fe3-8196-d837a909f038	360144da-2c0b-4e18-81b5-5dde9d7a3682	g.chr8:110455173_110455174insG	uc003yne.2	+	36	4498	c.4394_splice	c.e36-1	p.G1465_splice		NM_177531	NP_803875	Q86WI1	PKHL1_HUMAN	fibrocystin L precursor						immune response	cytosol|extracellular space|integral to membrane	receptor activity			ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			ATTTTATGGCAGGTTCATTTTC	0.322		NA								HNSCC(38;0.096)			9	119	---	---	---	---	NA	NA	NA	NA
COL22A1	169044	broad.mit.edu	37	8	139824126	139824127	+	In_Frame_Ins	INS	-	-	GGTGGA			TCGA-CV-7236-01A-11D-2012-08	TCGA-CV-7236-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dc220a9d-1f16-4fe3-8196-d837a909f038	360144da-2c0b-4e18-81b5-5dde9d7a3682	g.chr8:139824126_139824127insGGTGGA	uc003yvd.2	-	9	1811_1812	c.1364_1365insTCCACC	c.(1363-1365)CCC>CCTCCACCC	p.455_455P>PPP		NM_152888	NP_690848	Q8NFW1	COMA1_HUMAN	collagen, type XXII, alpha 1	455	Pro-rich.				cell adhesion	collagen|cytoplasm	structural molecule activity			ovary(11)|pancreas(1)|skin(1)	13	all_epithelial(106;1.55e-12)|Lung NSC(106;1.67e-05)|all_lung(105;3.39e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0517)			GCTGGGGTGGGGGTGGAGGTGG	0.599		NA								HNSCC(7;0.00092)			3	6	---	---	---	---	NA	NA	NA	NA
WNK3	65267	broad.mit.edu	37	X	54263432	54263434	+	In_Frame_Del	DEL	CAC	CAC	-			TCGA-CV-7236-01A-11D-2012-08	TCGA-CV-7236-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dc220a9d-1f16-4fe3-8196-d837a909f038	360144da-2c0b-4e18-81b5-5dde9d7a3682	g.chrX:54263432_54263434delCAC	uc004dtd.1	-	20	4863_4865	c.4424_4426delGTG	c.(4423-4428)AGTGAT>AAT	p.1475_1476SD>N	WNK3_uc004dtc.1_In_Frame_Del_p.1522_1523SD>N	NM_001002838	NP_001002838	Q9BYP7	WNK3_HUMAN	WNK lysine deficient protein kinase 3 isoform 2	1475_1476					intracellular protein kinase cascade|positive regulation of establishment of protein localization in plasma membrane|positive regulation of peptidyl-threonine phosphorylation|positive regulation of rubidium ion transmembrane transporter activity|positive regulation of rubidium ion transport|positive regulation of sodium ion transmembrane transporter activity|positive regulation of sodium ion transport|protein autophosphorylation	adherens junction|tight junction	ATP binding|protein binding|protein serine/threonine kinase activity|rubidium ion transmembrane transporter activity|sodium ion transmembrane transporter activity			lung(4)|ovary(3)|kidney(2)|central_nervous_system(2)	11						GATTCATCATCACTGCTCATTGG	0.433		NA											34	240	---	---	---	---	NA	NA	NA	NA