Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	isArtifactMode	oxoGCut
PRAMEF11	440560	broad.mit.edu	37	1	12887612	12887612	+	Missense_Mutation	SNP	T	T	C	rs60558629		TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr1:12887612T>C	uc001auk.2	-	3	441	c.245A>G	c.(244-246)CAT>CGT	p.H82R		NM_001146344	NP_001139816	O60813	PRA11_HUMAN	PRAME family member 11	82											0						GAAGCACCCATGGGCCATAGC	0.488		NA											6	258					0	0	0	0
PLEKHM2	23207	broad.mit.edu	37	1	16059015	16059015	+	Nonsense_Mutation	SNP	C	C	G			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr1:16059015C>G	uc010obo.1	+	18	3023	c.2796C>G	c.(2794-2796)TAC>TAG	p.Y932*		NM_015164	NP_055979	Q8IWE5	PKHM2_HUMAN	pleckstrin homology domain containing, family M	932					Golgi organization	cytoplasm	kinesin binding			ovary(1)	1		Colorectal(325;0.000259)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.00057)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;9.18e-07)|COAD - Colon adenocarcinoma(227;4.5e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000133)|KIRC - Kidney renal clear cell carcinoma(229;0.00262)|STAD - Stomach adenocarcinoma(313;0.00774)|READ - Rectum adenocarcinoma(331;0.0657)		GCAAGGAGTACTGCGTCTTGG	0.632		NA											8	8					0	0	0	0
COL24A1	255631	broad.mit.edu	37	1	86361734	86361734	+	Silent	SNP	A	A	G			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr1:86361734A>G	uc001dlj.2	-	30	2889	c.2847T>C	c.(2845-2847)GAT>GAC	p.D949D	COL24A1_uc001dli.2_Silent_p.D85D|COL24A1_uc010osd.1_Silent_p.D249D|COL24A1_uc001dlk.2_RNA|COL24A1_uc010ose.1_RNA|COL24A1_uc010osf.1_RNA	NM_152890	NP_690850	Q17RW2	COOA1_HUMAN	collagen, type XXIV, alpha 1 precursor	949	Collagen-like 8.				cell adhesion	collagen	extracellular matrix structural constituent			ovary(3)|central_nervous_system(1)|skin(1)	5				all cancers(265;0.0627)|Epithelial(280;0.0689)		TTTTTCCTTGATCTCCTTTTT	0.318		NA											10	26					0	0	0	0
LRRC8D	55144	broad.mit.edu	37	1	90400516	90400516	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr1:90400516G>C	uc001dnm.2	+	3	2314	c.1889G>C	c.(1888-1890)AGC>ACC	p.S630T	LRRC8D_uc001dnn.2_Missense_Mutation_p.S630T	NM_001134479	NP_001127951	Q7L1W4	LRC8D_HUMAN	leucine rich repeat containing 8 family, member	630	LRR 5.					integral to membrane	protein binding			ovary(2)	2		all_lung(203;0.0894)|Lung NSC(277;0.227)		all cancers(265;0.0109)|Epithelial(280;0.0427)		GTACTGAACAGCCTTAAGAAA	0.418		NA											6	65					0	0	0	0
PSMB4	5692	broad.mit.edu	37	1	151373789	151373789	+	Nonsense_Mutation	SNP	C	C	A			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr1:151373789C>A	uc001eyc.1	+	5	674	c.651C>A	c.(649-651)TGC>TGA	p.C217*	PSMB4_uc010pda.1_3'UTR|PSMB4_uc001eyb.1_3'UTR	NM_002796	NP_002787	P28070	PSB4_HUMAN	proteasome beta 4 subunit	217					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|interspecies interaction between organisms|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	cytoplasm|nucleus|proteasome core complex	threonine-type endopeptidase activity			ovary(2)	2	Lung SC(34;0.00471)|Ovarian(49;0.00871)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)			TAGAACGCTGCATGCGAGTGC	0.577		NA											25	146					3.08e-08	3.45e-08	1	0
SMCP	4184	broad.mit.edu	37	1	152856943	152856943	+	Silent	SNP	C	C	T			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr1:152856943C>T	uc001fat.2	+	2	190	c.45C>T	c.(43-45)GGC>GGT	p.G15G		NM_030663	NP_109588	P49901	MCSP_HUMAN	sperm mitochondria-associated cysteine-rich	15	2.|7 X 7 (OR 8) AA approximate repeats.				penetration of zona pellucida|sperm motility	mitochondrial membrane					0	Lung NSC(65;3.97e-29)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.171)			CAGCAAAAGGCAATCAATGCT	0.458		NA											16	48					0	0	0	0
PRCC	5546	broad.mit.edu	37	1	156756890	156756890	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr1:156756890C>T	uc001fqa.2	+	3	1297	c.1007C>T	c.(1006-1008)CCT>CTT	p.P336L	PRCC_uc001fqb.2_Missense_Mutation_p.P336L	NM_005973	NP_005964	Q92733	PRCC_HUMAN	papillary renal cell carcinoma	336					cell cycle|mitotic cell cycle checkpoint	nucleus	protein binding		PRCC/TFE3(25)	kidney(25)|central_nervous_system(2)	27	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					CCTTGGATGCCTAAGCCTGGG	0.572		NA	T	TFE3	papillary renal 								89	181					0	0	0	0
CD1D	912	broad.mit.edu	37	1	158152716	158152716	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr1:158152716G>A	uc001frr.2	+	5	1155	c.656G>A	c.(655-657)CGT>CAT	p.R219H	CD1D_uc009wss.2_Intron	NM_001766	NP_001757	P15813	CD1D_HUMAN	CD1D antigen precursor	219	Ig-like.|Extracellular (Potential).				antigen processing and presentation, endogenous lipid antigen via MHC class Ib|detection of bacterium|innate immune response|interspecies interaction between organisms|positive regulation of innate immune response|T cell selection	endosome membrane|integral to plasma membrane|lysosomal membrane	beta-2-microglobulin binding|exogenous lipid antigen binding|histone binding			ovary(1)	1	all_hematologic(112;0.0378)					GGCCCTGGCCGTCTGCTGCTG	0.592		NA											12	95					0	0	0	0
ARHGAP30	257106	broad.mit.edu	37	1	161018149	161018149	+	Missense_Mutation	SNP	C	C	A			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr1:161018149C>A	uc001fxl.2	-	12	3008	c.2662G>T	c.(2662-2664)GTA>TTA	p.V888L	USF1_uc001fxi.2_5'Flank|USF1_uc001fxj.2_5'Flank|ARHGAP30_uc001fxk.2_Intron|ARHGAP30_uc001fxm.2_Missense_Mutation_p.V734L|ARHGAP30_uc009wtx.2_Missense_Mutation_p.V561L	NM_001025598	NP_001020769	Q7Z6I6	RHG30_HUMAN	Rho GTPase activating protein 30 isoform 1	888	Glu-rich.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			ovary(2)|upper_aerodigestive_tract(1)	3	all_cancers(52;8.05e-20)|Breast(13;0.00188)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00122)			TGTGGGGCTACCTCTTCCATC	0.587		NA											16	34					1.57e-10	1.79e-10	1	0
POGK	57645	broad.mit.edu	37	1	166818317	166818317	+	Silent	SNP	G	G	A			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr1:166818317G>A	uc001gdt.1	+	5	621	c.501G>A	c.(499-501)GGG>GGA	p.G167G	POGK_uc010ple.1_Silent_p.G82G|POGK_uc010plf.1_Silent_p.G49G	NM_017542	NP_060012	Q9P215	POGK_HUMAN	pogo transposable element with KRAB domain	167					multicellular organismal development|regulation of transcription, DNA-dependent	nucleus	DNA binding			ovary(1)	1						GGAGTGAGGGGTACCCCTTCT	0.577		NA											9	54					0	0	0	0
F5	2153	broad.mit.edu	37	1	169511310	169511310	+	Missense_Mutation	SNP	A	A	C			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr1:169511310A>C	uc001ggg.1	-	13	3163	c.3018T>G	c.(3016-3018)CAT>CAG	p.H1006Q		NM_000130	NP_000121	P12259	FA5_HUMAN	coagulation factor V precursor	1006	B.				cell adhesion|platelet activation|platelet degranulation	plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity			ovary(3)|large_intestine(1)|central_nervous_system(1)|skin(1)	6	all_hematologic(923;0.208)				Drotrecogin alfa(DB00055)	GTAGAGATTTATGTCTAACTC	0.463		NA											17	209					0	0	0	0
FMO1	2326	broad.mit.edu	37	1	171249964	171249964	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr1:171249964C>T	uc009wvz.2	+	6	803	c.667C>T	c.(667-669)CGA>TGA	p.R223*	FMO1_uc010pme.1_Nonsense_Mutation_p.R160*|FMO1_uc001ghl.2_Nonsense_Mutation_p.R223*|FMO1_uc001ghm.2_Nonsense_Mutation_p.R223*|FMO1_uc001ghn.2_Nonsense_Mutation_p.R223*	NM_002021	NP_002012	Q01740	FMO1_HUMAN	flavin containing monooxygenase 1	223					NADPH oxidation|organic acid metabolic process|toxin metabolic process|xenobiotic metabolic process	endoplasmic reticulum lumen|integral to membrane|intrinsic to endoplasmic reticulum membrane|microsome	flavin adenine dinucleotide binding|flavin-containing monooxygenase activity|NADP binding			skin(1)	1	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					GGTGATCAGCCGAATCTTTGA	0.517		NA											3	48					0	0	0	0
SLC26A9	115019	broad.mit.edu	37	1	205888028	205888028	+	Silent	SNP	G	G	A			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr1:205888028G>A	uc001hdq.2	-	19	2310	c.2196C>T	c.(2194-2196)GAC>GAT	p.D732D	SLC26A9_uc001hdm.2_5'Flank|SLC26A9_uc001hdn.2_5'Flank|SLC26A9_uc001hdo.2_Silent_p.D400D|SLC26A9_uc001hdp.2_Silent_p.D732D	NM_052934	NP_443166	Q7LBE3	S26A9_HUMAN	solute carrier family 26, member 9 isoform a	732	STAS.					integral to membrane	chloride channel activity|secondary active sulfate transmembrane transporter activity			ovary(1)|skin(1)	2	Breast(84;0.201)		BRCA - Breast invasive adenocarcinoma(75;0.0458)			AGAGGACTGCGTCATGTATGC	0.522		NA									OREG0014164	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	53	259					0	0	0	0
SERTAD4	56256	broad.mit.edu	37	1	210415025	210415025	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr1:210415025G>C	uc001hhy.2	+	4	593	c.414G>C	c.(412-414)AGG>AGC	p.R138S	SERTAD4_uc009xcw.2_Missense_Mutation_p.R138S	NM_019605	NP_062551	Q9NUC0	SRTD4_HUMAN	SERTA domain containing 4	138	SERTA.						protein binding			ovary(1)|pancreas(1)	2				OV - Ovarian serous cystadenocarcinoma(81;0.0237)|all cancers(67;0.127)		TGATGAAAAGGATCCATGGAG	0.428		NA											24	149					0	0	0	0
ANGEL2	90806	broad.mit.edu	37	1	213181634	213181634	+	Missense_Mutation	SNP	T	T	C			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr1:213181634T>C	uc001hjz.2	-	3	715	c.560A>G	c.(559-561)TAT>TGT	p.Y187C	ANGEL2_uc010pto.1_Missense_Mutation_p.Y61C|ANGEL2_uc010ptp.1_Missense_Mutation_p.Y61C|ANGEL2_uc001hka.2_Missense_Mutation_p.Y18C|ANGEL2_uc010ptq.1_RNA|ANGEL2_uc001hkb.2_Missense_Mutation_p.Y165C	NM_144567	NP_653168	Q5VTE6	ANGE2_HUMAN	LOC90806 protein	187											0				OV - Ovarian serous cystadenocarcinoma(81;0.00446)|all cancers(67;0.0169)|Epithelial(68;0.0921)|GBM - Glioblastoma multiforme(131;0.185)		GCAATGTCTATAAAGGTGAGA	0.353		NA											20	77					0	0	0	0
SIPA1L2	57568	broad.mit.edu	37	1	232600688	232600688	+	Silent	SNP	T	T	C			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr1:232600688T>C	uc001hvg.2	-	7	2876	c.2718A>G	c.(2716-2718)GGA>GGG	p.G906G	SIPA1L2_uc001hvf.2_5'Flank	NM_020808	NP_065859	Q9P2F8	SI1L2_HUMAN	signal-induced proliferation-associated 1 like	906					regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			ovary(2)|central_nervous_system(2)|pancreas(1)|skin(1)	6		all_cancers(173;0.00605)|Prostate(94;0.128)|all_epithelial(177;0.186)				TACTCACTAATCCAGATGTCC	0.428		NA											44	43					0	0	0	0
AKT3	10000	broad.mit.edu	37	1	243809217	243809217	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr1:243809217G>C	uc001iab.1	-	4	488	c.407C>G	c.(406-408)TCT>TGT	p.S136C	AKT3_uc001hzz.1_Missense_Mutation_p.S136C	NM_005465	NP_005456	Q9Y243	AKT3_HUMAN	AKT3 kinase isoform 1	136					signal transduction	Golgi apparatus|nucleus|plasma membrane	ATP binding|protein binding|protein serine/threonine kinase activity			stomach(1)|lung(1)|breast(1)|central_nervous_system(1)	4	all_cancers(71;0.000307)|all_epithelial(71;0.000374)|all_lung(81;0.0323)|Ovarian(71;0.0619)|all_neural(11;0.101)|Lung NSC(105;0.168)	all_cancers(173;0.0274)	all cancers(7;4.3e-08)|GBM - Glioblastoma multiforme(7;5.12e-06)|OV - Ovarian serous cystadenocarcinoma(106;0.00196)			ATGGGTTGTAGAGGCATCCAT	0.383		NA											8	61					0	0	0	0
PLXDC2	84898	broad.mit.edu	37	10	20335831	20335831	+	Missense_Mutation	SNP	A	A	G			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr10:20335831A>G	uc001iqg.1	+	3	995	c.358A>G	c.(358-360)ATA>GTA	p.I120V	PLXDC2_uc001iqh.1_Intron	NM_032812	NP_116201	Q6UX71	PXDC2_HUMAN	plexin domain containing 2 precursor	120	Extracellular (Potential).					integral to membrane				ovary(2)|central_nervous_system(1)|skin(1)	4						TATATCTCGAATATATGGTCC	0.328		NA											11	88					0	0	0	0
GPR158	57512	broad.mit.edu	37	10	25861578	25861578	+	Missense_Mutation	SNP	G	G	T			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr10:25861578G>T	uc001isj.2	+	7	1575	c.1515G>T	c.(1513-1515)AGG>AGT	p.R505S		NM_020752	NP_065803	Q5T848	GP158_HUMAN	G protein-coupled receptor 158 precursor	505	Helical; Name=3; (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(4)|large_intestine(2)|pancreas(1)|skin(1)	8						GCTTTTCTAGGGTTTTGAAGG	0.368		NA											12	67					1.58e-08	1.78e-08	1	0
PPYR1	5540	broad.mit.edu	37	10	47087866	47087866	+	Silent	SNP	C	C	A			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr10:47087866C>A	uc001jee.2	+	3	1502	c.1083C>A	c.(1081-1083)GTC>GTA	p.V361V	ANXA8_uc001jed.3_Intron|PPYR1_uc009xna.2_Silent_p.V361V	NM_005972	NP_005963	P50391	NPY4R_HUMAN	pancreatic polypeptide receptor 1	361	Cytoplasmic (Potential).				blood circulation|digestion|feeding behavior	integral to plasma membrane				ovary(1)|skin(1)	2						ATACGGAAGTCTCCAAAGGGT	0.567		NA											21	108					0.00465635	0.00487513	1	0
GDF10	2662	broad.mit.edu	37	10	48428782	48428782	+	Silent	SNP	C	C	T			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr10:48428782C>T	uc001jfb.2	-	2	1560	c.1104G>A	c.(1102-1104)AAG>AAA	p.K368K	GDF10_uc009xnp.2_Silent_p.K367K|GDF10_uc009xnq.1_Silent_p.K368K	NM_004962	NP_004953	P55107	BMP3B_HUMAN	growth differentiation factor 10 precursor	368					growth|skeletal system development|transforming growth factor beta receptor signaling pathway	extracellular space	cytokine activity|growth factor activity			lung(1)|central_nervous_system(1)	2						CATCCCACTGCTTCCTCCGGG	0.572		NA											26	39					0	0	0	0
NRAP	4892	broad.mit.edu	37	10	115365978	115365978	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr10:115365978C>T	uc001laj.2	-	33	3930	c.3766G>A	c.(3766-3768)GAG>AAG	p.E1256K	NRAP_uc009xyb.2_Intron|NRAP_uc001lak.2_Missense_Mutation_p.E1221K|NRAP_uc001lal.3_Missense_Mutation_p.E1256K	NM_198060	NP_932326	Q86VF7	NRAP_HUMAN	nebulin-related anchoring protein isoform S	1256	Nebulin 33.					fascia adherens|muscle tendon junction	actin binding|muscle alpha-actinin binding|zinc ion binding			ovary(6)|central_nervous_system(3)|upper_aerodigestive_tract(1)	10		Colorectal(252;0.0233)|Breast(234;0.188)		Epithelial(162;0.00392)|all cancers(201;0.00569)		CGGATGAACTCGGGCAGACCC	0.438		NA											20	29					0	0	0	0
MRGPRX3	117195	broad.mit.edu	37	11	18158851	18158851	+	Silent	SNP	G	G	A			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr11:18158851G>A	uc001mnu.2	+	3	463	c.102G>A	c.(100-102)ACG>ACA	p.T34T		NM_054031	NP_473372	Q96LB0	MRGX3_HUMAN	MAS-related GPR, member X3	34	Helical; Name=1; (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(1)|pancreas(1)	2						CGGGGCTGACGTGCATCGTTT	0.572		NA											16	103					0	0	0	0
GAS2	2620	broad.mit.edu	37	11	22696395	22696395	+	Splice_Site	SNP	G	G	A			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr11:22696395G>A	uc009yie.2	+	2	287	c.-19_splice	c.e2-1		GAS2_uc001mqm.2_Splice_Site|GAS2_uc001mqn.2_Splice_Site|GAS2_uc001mqo.2_5'UTR	NM_001143830	NP_001137302	O43903	GAS2_HUMAN	growth arrest-specific 2						cell cycle arrest|cellular component disassembly involved in apoptosis|regulation of cell shape	actin filament|cytosol|membrane				ovary(1)|skin(1)	2						TTCCAAAACAGGTATTACAAG	0.418		NA											8	20					0	0	0	0
MRPL16	54948	broad.mit.edu	37	11	59575303	59575303	+	Missense_Mutation	SNP	T	T	G			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr11:59575303T>G	uc001noh.2	-	3	355	c.141A>C	c.(139-141)AAA>AAC	p.K47N		NM_017840	NP_060310	Q9NX20	RM16_HUMAN	mitochondrial ribosomal protein L16 precursor	47							rRNA binding			central_nervous_system(1)	1						TAAGCTTGGGTTTTTCAGGAA	0.368		NA											11	160					0	0	0	0
MS4A15	219995	broad.mit.edu	37	11	60543106	60543106	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr11:60543106G>A	uc009ynf.1	+	7	861	c.641G>A	c.(640-642)AGC>AAC	p.S214N	MS4A15_uc001npx.2_Missense_Mutation_p.S121N|MS4A15_uc001npy.2_RNA|MS4A15_uc009yng.1_Missense_Mutation_p.S173N	NM_001098835	NP_001092305	Q8N5U1	M4A15_HUMAN	membrane-spanning 4-domains, subfamily A, member	214						integral to membrane	receptor activity			lung(1)	1						AACGCCTTCAGCGCAGACTTC	0.577		NA									OREG0020991	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	45	156					0	0	0	0
AHNAK	79026	broad.mit.edu	37	11	62298958	62298958	+	Silent	SNP	G	G	A			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr11:62298958G>A	uc001ntl.2	-	5	3231	c.2931C>T	c.(2929-2931)GGC>GGT	p.G977G	AHNAK_uc001ntk.1_Intron	NM_001620	NP_001611	Q09666	AHNK_HUMAN	AHNAK nucleoprotein isoform 1	977					nervous system development	nucleus	protein binding			ovary(10)|pancreas(4)|skin(4)|upper_aerodigestive_tract(1)	19		Melanoma(852;0.155)				CTACTTTTGGGCCTTTCAGGT	0.463		NA											24	104					0	0	0	0
SLC22A12	116085	broad.mit.edu	37	11	64361159	64361159	+	Silent	SNP	T	T	C			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr11:64361159T>C	uc001oam.1	+	4	1461	c.714T>C	c.(712-714)TCT>TCC	p.S238S	SLC22A12_uc009ypr.1_Silent_p.S263S|SLC22A12_uc001oal.1_Silent_p.S17S|SLC22A12_uc009yps.1_Silent_p.S204S|SLC22A12_uc001oan.1_Intron|SLC22A12_uc009ypt.2_Silent_p.S56S	NM_144585	NP_653186	Q96S37	S22AC_HUMAN	urate anion exchanger 1 isoform a	238	Helical; (Potential).				cellular homeostasis|response to drug|urate metabolic process	apical plasma membrane|brush border membrane|integral to membrane	PDZ domain binding|urate transmembrane transporter activity			ovary(1)	1						CCTTGAACTCTCTGGGCTTCA	0.642		NA											10	29					0	0	0	0
ALKBH8	91801	broad.mit.edu	37	11	107427562	107427562	+	Silent	SNP	G	G	A			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr11:107427562G>A	uc010rvr.1	-	3	372	c.297C>T	c.(295-297)ACC>ACT	p.T99T	ALKBH8_uc010rvq.1_5'UTR|ALKBH8_uc009yxp.2_Silent_p.T99T|ALKBH8_uc001pjl.2_RNA	NM_138775	NP_620130	Q96BT7	ALKB8_HUMAN	alkB, alkylation repair homolog 8	99	RRM.				response to DNA damage stimulus	cytosol|nucleus	metal ion binding|nucleotide binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors|protein binding|RNA binding|tRNA (uracil) methyltransferase activity				0		Melanoma(852;0.000288)|Acute lymphoblastic leukemia(157;0.000966)|all_hematologic(158;0.00301)|all_epithelial(67;0.00512)|Breast(348;0.104)		BRCA - Breast invasive adenocarcinoma(274;3.53e-05)|Epithelial(105;0.00029)|all cancers(92;0.00518)		TTCCATTGAGGGTAACATAGG	0.348		NA											5	33					0	0	0	0
ARHGEF12	23365	broad.mit.edu	37	11	120346103	120346103	+	Missense_Mutation	SNP	A	A	T			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr11:120346103A>T	uc001pxl.1	+	33	3171	c.3164A>T	c.(3163-3165)GAT>GTT	p.D1055V	ARHGEF12_uc009zat.2_Missense_Mutation_p.D1036V|ARHGEF12_uc010rzn.1_Missense_Mutation_p.D952V|ARHGEF12_uc009zau.1_Missense_Mutation_p.D952V	NM_015313	NP_056128	Q9NZN5	ARHGC_HUMAN	Rho guanine nucleotide exchange factor (GEF) 12	1055	PH.				apoptosis|axon guidance|G-protein coupled receptor protein signaling pathway|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|membrane	G-protein-coupled receptor binding|GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			lung(2)|breast(2)|skin(2)|ovary(1)	7		Breast(109;0.000813)|Medulloblastoma(222;0.0425)|Hepatocellular(160;0.0831)|all_hematologic(192;0.107)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.231)		AAGCAGGATGATAGACTGGTT	0.333		NA	T	MLL	AML								8	69					0	0	0	0
ROBO3	64221	broad.mit.edu	37	11	124744033	124744033	+	Missense_Mutation	SNP	G	G	A	rs74787566	by1000genomes	TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr11:124744033G>A	uc001qbc.2	+	12	2044	c.1852G>A	c.(1852-1854)GGT>AGT	p.G618S	ROBO3_uc010saq.1_5'Flank|ROBO3_uc001qbd.2_5'Flank|ROBO3_uc010sar.1_5'Flank|ROBO3_uc001qbe.2_5'Flank	NM_022370	NP_071765	Q96MS0	ROBO3_HUMAN	roundabout, axon guidance receptor, homolog 3	618	Fibronectin type-III 1.|Extracellular (Potential).				axon midline choice point recognition	integral to membrane	receptor activity			breast(1)|central_nervous_system(1)	2	all_hematologic(175;0.215)	Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|Breast(109;0.0481)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.5e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0296)		CACAGTCAGCGGTCTGCAGCC	0.587		NA											6	73					0	0	0	0
B4GALNT3	283358	broad.mit.edu	37	12	653525	653525	+	Silent	SNP	G	G	A			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr12:653525G>A	uc001qii.1	+	4	372	c.372G>A	c.(370-372)CTG>CTA	p.L124L	B4GALNT3_uc001qij.1_Silent_p.L26L	NM_173593	NP_775864	Q6L9W6	B4GN3_HUMAN	beta	124	Lumenal (Potential).					Golgi cisterna membrane|integral to membrane	N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity			ovary(1)|skin(1)	2	all_cancers(10;0.0158)|all_epithelial(11;0.0274)|Ovarian(42;0.0512)|all_lung(10;0.154)|Lung NSC(10;0.215)		OV - Ovarian serous cystadenocarcinoma(31;0.00018)|BRCA - Breast invasive adenocarcinoma(9;0.0262)			GTGCCAACCTGCATGTGTTTG	0.632		NA											9	75					0	0	0	0
AQP2	359	broad.mit.edu	37	12	50344816	50344816	+	Missense_Mutation	SNP	A	A	C	rs104894331		TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr12:50344816A>C	uc001rvn.2	+	1	293	c.203A>C	c.(202-204)AAC>ACC	p.N68T		NM_000486	NP_000477	P41181	AQP2_HUMAN	aquaporin 2	68	Cytoplasmic (Potential).|NPA 1.		N -> S (in ANDI).		cellular response to copper ion|cellular response to mercury ion|excretion	apical plasma membrane|integral to membrane|transport vesicle membrane	glycerol transmembrane transporter activity|water channel activity			ovary(2)	2						GCCCACATCAACCCTGCCGTG	0.662		NA											9	35					0	0	0	0
ZBTB39	9880	broad.mit.edu	37	12	57396829	57396829	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr12:57396829G>A	uc001sml.1	-	2	1959	c.1873C>T	c.(1873-1875)CGG>TGG	p.R625W	RDH16_uc010sqx.1_5'Flank	NM_014830	NP_055645	O15060	ZBT39_HUMAN	zinc finger and BTB domain containing 39	625	C2H2-type 6.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)	1						GTGTGGATCCGCCGGTGGTAG	0.557		NA											9	70					0	0	0	0
TMEM132D	121256	broad.mit.edu	37	12	129569218	129569218	+	Silent	SNP	G	G	T			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr12:129569218G>T	uc009zyl.1	-	6	1801	c.1473C>A	c.(1471-1473)GTC>GTA	p.V491V	TMEM132D_uc001uia.2_Silent_p.V29V	NM_133448	NP_597705	Q14C87	T132D_HUMAN	transmembrane protein 132D precursor	491	Extracellular (Potential).					integral to membrane				ovary(10)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	14	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0934)|Breast(359;0.133)		OV - Ovarian serous cystadenocarcinoma(86;0.000288)|Epithelial(86;0.0116)|all cancers(50;0.0246)		CTTTCCCATTGACAAAGACGT	0.542		NA											7	28					2.01e-06	2.22e-06	1	0
ANKLE2	23141	broad.mit.edu	37	12	133319798	133319798	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr12:133319798G>A	uc001ukx.2	-	6	1362	c.1295C>T	c.(1294-1296)TCG>TTG	p.S432L	ANKLE2_uc001uky.3_Missense_Mutation_p.S370L	NM_015114	NP_055929	Q86XL3	ANKL2_HUMAN	ankyrin repeat and LEM domain containing 2	432	ANK.					cytoplasm|integral to membrane|nuclear envelope					0	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0176)|Lung NSC(355;0.204)		OV - Ovarian serous cystadenocarcinoma(86;2.3e-08)|Epithelial(86;1.56e-07)|all cancers(50;4.94e-06)		ATGGTGTGACGAAAGCACGTT	0.353		NA											6	25					0	0	0	0
OR4N2	390429	broad.mit.edu	37	14	20295720	20295720	+	Missense_Mutation	SNP	T	T	C			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr14:20295720T>C	uc010tkv.1	+	1	113	c.113T>C	c.(112-114)ATC>ACC	p.I38T		NM_001004723	NP_001004723	Q8NGD1	OR4N2_HUMAN	olfactory receptor, family 4, subfamily N,	38	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|central_nervous_system(1)|skin(1)	4	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		TACTTCATCATCCTCCCTGGA	0.438		NA											20	277					0	0	0	0
METTL3	56339	broad.mit.edu	37	14	21971333	21971333	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr14:21971333C>T	uc001wbc.2	-	3	798	c.706G>A	c.(706-708)GAA>AAA	p.E236K	METTL3_uc001wbb.2_Missense_Mutation_p.E81K|METTL3_uc010tlw.1_RNA|METTL3_uc010tlx.1_Missense_Mutation_p.E236K|METTL3_uc001wbd.1_Missense_Mutation_p.E236K	NM_019852	NP_062826	Q86U44	MTA70_HUMAN	methyltransferase like 3	236					gene expression	nuclear speck	mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity|RNA binding			pancreas(1)|skin(1)	2	all_cancers(95;0.000628)		Epithelial(56;6.61e-06)	GBM - Glioblastoma multiforme(265;0.0146)		CTCTGTTGTTCCTTAGTGGAC	0.448		NA											38	114					0	0	0	0
RTN1	6252	broad.mit.edu	37	14	60212930	60212930	+	Missense_Mutation	SNP	T	T	C			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr14:60212930T>C	uc001xen.1	-	2	720	c.511A>G	c.(511-513)ACT>GCT	p.T171A		NM_021136	NP_066959	Q16799	RTN1_HUMAN	reticulon 1 isoform A	171					neuron differentiation	integral to endoplasmic reticulum membrane	signal transducer activity			ovary(2)|central_nervous_system(2)	4				OV - Ovarian serous cystadenocarcinoma(108;0.0968)		TCTGCAGGAGTCATCTCTATT	0.507		NA											32	36					0	0	0	0
SYNE2	23224	broad.mit.edu	37	14	64486767	64486767	+	Missense_Mutation	SNP	A	A	G			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr14:64486767A>G	uc001xgm.2	+	35	5337	c.5107A>G	c.(5107-5109)ATA>GTA	p.I1703V	SYNE2_uc001xgl.2_Missense_Mutation_p.I1703V	NM_015180	NP_055995	Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	1703	Cytoplasmic (Potential).|Potential.				centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			ovary(8)|breast(4)|central_nervous_system(1)|pancreas(1)	14				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		AGTGGCTGAAATACAGTTTTT	0.249		NA											14	72					0	0	0	0
ITPK1	3705	broad.mit.edu	37	14	93412779	93412779	+	Silent	SNP	G	G	A			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr14:93412779G>A	uc001ybg.2	-	10	1087	c.798C>T	c.(796-798)TCC>TCT	p.S266S	ITPK1_uc001ybe.2_Silent_p.S266S|ITPK1_uc001ybf.2_Silent_p.S147S|ITPK1_uc001ybh.2_Silent_p.S266S	NM_014216	NP_055031	Q13572	ITPK1_HUMAN	inositol 1,3,4-triphosphate 5/6 kinase isoform	266	ATP-grasp.				blood coagulation|inositol trisphosphate metabolic process|signal transduction	cytosol	ATP binding|hydrolase activity|inositol tetrakisphosphate 1-kinase activity|inositol-1,3,4-trisphosphate 5/6-kinase activity|isomerase activity|ligase activity|magnesium ion binding				0		all_cancers(154;0.077)|all_epithelial(191;0.247)		Epithelial(152;0.124)|all cancers(159;0.169)		GCAGGGCCCGGGAGAGCTCCC	0.617		NA											12	43					0	0	0	0
VPS33B	26276	broad.mit.edu	37	15	91557634	91557634	+	Missense_Mutation	SNP	T	T	C			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr15:91557634T>C	uc002bqp.1	-	4	623	c.269A>G	c.(268-270)AAG>AGG	p.K90R	VPS33B_uc002bqq.1_5'UTR|VPS33B_uc010uqu.1_Missense_Mutation_p.K63R	NM_018668	NP_061138	Q9H267	VP33B_HUMAN	vacuolar protein sorting 33B (yeast homolog))	90					cellular membrane fusion|lysosome localization|melanosome localization|platelet alpha granule organization|protein transport|vesicle docking involved in exocytosis	late endosome membrane|lysosomal membrane|perinuclear region of cytoplasm|platelet alpha granule	protein binding			ovary(2)	2	Lung NSC(78;0.0987)|all_lung(78;0.175)					TCGCATATTCTTGATGCGGGG	0.428		NA											33	144					0	0	0	0
MSLNL	401827	broad.mit.edu	37	16	830539	830539	+	Silent	SNP	C	C	T			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr16:830539C>T	uc002cjz.1	-	3	462	c.462G>A	c.(460-462)CCG>CCA	p.P154P		NM_001025190	NP_001020361	Q96KJ4	MSLNL_HUMAN	mesothelin-like	Error:Variant_position_missing_in_Q96KJ4_after_alignment					cell adhesion	integral to membrane				breast(3)|ovary(1)	4						ACAGTGTGCACGGGTAGGTGA	0.562		NA											12	93					0	0	0	0
TNRC6A	27327	broad.mit.edu	37	16	24826581	24826581	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr16:24826581C>T	uc002dmm.2	+	19	4900	c.4786C>T	c.(4786-4788)CGT>TGT	p.R1596C	TNRC6A_uc010bxs.2_Missense_Mutation_p.R1343C|TNRC6A_uc002dmn.2_Missense_Mutation_p.R1294C|TNRC6A_uc002dmo.2_Missense_Mutation_p.R1235C|TNRC6A_uc002dmp.2_Missense_Mutation_p.R197C|TNRC6A_uc002dmq.2_Missense_Mutation_p.R263C	NM_014494	NP_055309	Q8NDV7	TNR6A_HUMAN	trinucleotide repeat containing 6A	1596					negative regulation of translation involved in gene silencing by miRNA	cytoplasmic mRNA processing body|micro-ribonucleoprotein complex	nucleotide binding|RNA binding			ovary(2)	2				GBM - Glioblastoma multiforme(48;0.0394)		TGGCTGGCCACGTGCCAAATC	0.448		NA											7	31					0	0	0	0
CDH16	1014	broad.mit.edu	37	16	66945163	66945163	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr16:66945163C>T	uc002eql.2	-	14	1919	c.1846G>A	c.(1846-1848)GAG>AAG	p.E616K	CDH16_uc010cdy.2_Missense_Mutation_p.E616K|CDH16_uc002eqm.2_Missense_Mutation_p.E519K	NM_004062	NP_004053	O75309	CAD16_HUMAN	cadherin 16 precursor	616	Extracellular (Potential).|Cadherin 6.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)|upper_aerodigestive_tract(1)	3		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0877)|Epithelial(162;0.203)		GTGTGCACCTCCCCGGAGAAT	0.597		NA											3	18					0	0	0	0
PMFBP1	83449	broad.mit.edu	37	16	72173223	72173223	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr16:72173223G>A	uc002fcc.3	-	7	1055	c.883C>T	c.(883-885)CCT>TCT	p.P295S	PMFBP1_uc002fcd.2_Missense_Mutation_p.P295S|PMFBP1_uc002fce.2_RNA|PMFBP1_uc002fcf.2_Missense_Mutation_p.P150S	NM_031293	NP_112583	Q8TBY8	PMFBP_HUMAN	polyamine modulated factor 1 binding protein 1	295										ovary(2)	2		Ovarian(137;0.179)				GAGGAGCTAGGAGGGTATCTG	0.463		NA											4	15					0	0	0	0
PKD1L2	114780	broad.mit.edu	37	16	81142842	81142842	+	Missense_Mutation	SNP	T	T	C			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr16:81142842T>C	uc002fgh.1	-	43	7043	c.7043A>G	c.(7042-7044)GAG>GGG	p.E2348G	PKD1L2_uc002fgf.1_Missense_Mutation_p.E148G|PKD1L2_uc002fgg.1_RNA	NM_052892	NP_443124	Q7Z442	PK1L2_HUMAN	polycystin 1-like 2 isoform a	2348	Channel pore-region.|Cytoplasmic (Potential).				neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity|sugar binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3						GACCATCGTCTCCGCCGCATC	0.398		NA											4	9					0	0	0	0
SLC25A35	399512	broad.mit.edu	37	17	8197904	8197904	+	Silent	SNP	G	G	A			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr17:8197904G>A	uc002gla.3	-	1	267	c.222C>T	c.(220-222)TTC>TTT	p.F74F	SLC25A35_uc002gku.1_Silent_p.F74F|SLC25A35_uc002gkt.2_Silent_p.F74F|SLC25A35_uc002gkz.1_RNA	NM_201520	NP_958928	Q3KQZ1	S2535_HUMAN	solute carrier family 25, member 35	74	Solcar 1.|Helical; Name=2; (Potential).				transport	integral to membrane|mitochondrial inner membrane					0						CATTCATCAGGAACTGGTACA	0.627		NA											9	37					0	0	0	0
MYH8	4626	broad.mit.edu	37	17	10296168	10296168	+	Missense_Mutation	SNP	T	T	C			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr17:10296168T>C	uc002gmm.2	-	37	5538	c.5443A>G	c.(5443-5445)ATC>GTC	p.I1815V	uc002gml.1_Intron	NM_002472	NP_002463	P13535	MYH8_HUMAN	myosin, heavy chain 8, skeletal muscle,	1815	Potential.				muscle filament sliding	cytosol|muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			skin(6)|ovary(3)|breast(2)	11						AGTTTCTGGATCTGCTTCTTC	0.552		NA							Trismus-Pseudocamptodactyly_Syndrome_with_Cardiac_Myxoma_and_Freckling				18	121					0	0	0	0
NCOR1	9611	broad.mit.edu	37	17	15971267	15971267	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr17:15971267C>T	uc002gpo.2	-	32	4922	c.4682G>A	c.(4681-4683)CGG>CAG	p.R1561Q	NCOR1_uc002gpn.2_Missense_Mutation_p.R1577Q|NCOR1_uc002gpm.2_Missense_Mutation_p.R82Q|NCOR1_uc010vwb.1_Missense_Mutation_p.R145Q|NCOR1_uc010coy.2_Missense_Mutation_p.R469Q|NCOR1_uc010vwc.1_Missense_Mutation_p.R372Q	NM_006311	NP_006302	O75376	NCOR1_HUMAN	nuclear receptor co-repressor 1	1561	Interaction with ETO.|Interaction with C1D (By similarity).			R -> W (in Ref. 1; AAC33550).	cellular lipid metabolic process|chromatin modification|negative regulation of JNK cascade|regulation of glycolysis by negative regulation of transcription from an RNA polymerase II promoter|regulation of lipid transport by negative regulation of transcription from an RNA polymerase II promoter|spindle assembly|transcription from RNA polymerase II promoter	nuclear chromatin|spindle microtubule|transcriptional repressor complex	histone deacetylase binding|transcription corepressor activity|transcription regulatory region DNA binding			upper_aerodigestive_tract(2)|ovary(1)|central_nervous_system(1)|kidney(1)	5				UCEC - Uterine corpus endometrioid carcinoma (92;0.101)		CAGGTGGCTCCGATAAACCTC	0.512		NA											9	40					0	0	0	0
MYO15A	51168	broad.mit.edu	37	17	18052259	18052259	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr17:18052259C>T	uc010vxh.1	+	32	7287	c.6949C>T	c.(6949-6951)CCC>TCC	p.P2317S		NM_016239	NP_057323	Q9UKN7	MYO15_HUMAN	myosin XV	2317	Tail.				sensory perception of sound	cytoplasm|myosin complex|stereocilium	actin binding|ATP binding|calmodulin binding|motor activity			skin(4)|ovary(2)|pancreas(1)|breast(1)|central_nervous_system(1)	9	all_neural(463;0.228)					CAGGGGAGGCCCCAAAGTGTA	0.642		NA											2	4					0	0	0	0
ACCN1	40	broad.mit.edu	37	17	32483504	32483504	+	Silent	SNP	G	G	A			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr17:32483504G>A	uc002hhu.2	-	1	322	c.48C>T	c.(46-48)AGC>AGT	p.S16S		NM_001094	NP_001085	Q16515	ACCN1_HUMAN	amiloride-sensitive cation channel 1, neuronal	16	Cytoplasmic (By similarity).				central nervous system development|peripheral nervous system development|synaptic transmission	integral to plasma membrane	ligand-gated sodium channel activity|protein binding			ovary(2)|large_intestine(1)|central_nervous_system(1)	4		Breast(31;0.042)|Ovarian(249;0.202)		UCEC - Uterine corpus endometrioid carcinoma (308;0.13)|BRCA - Breast invasive adenocarcinoma(366;0.215)	Amiloride(DB00594)	AGATCTGGATGCTAGAAGGTT	0.587		NA											14	25					0	0	0	0
C17orf66	256957	broad.mit.edu	37	17	34185484	34185484	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr17:34185484C>T	uc002hke.1	-	10	1134	c.985G>A	c.(985-987)GTC>ATC	p.V329I	C17orf66_uc010wck.1_RNA|C17orf66_uc010wcl.1_Missense_Mutation_p.V289I|C17orf66_uc010wcm.1_Missense_Mutation_p.V295I	NM_152781	NP_689994	A2RTY3	CQ066_HUMAN	hypothetical protein LOC256957	329							binding			breast(2)|skin(1)	3		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0184)		GCCTTGATGACTGGGGCTGAG	0.572		NA											3	24					0	0	0	0
ACACA	31	broad.mit.edu	37	17	35600372	35600372	+	Missense_Mutation	SNP	G	G	T			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr17:35600372G>T	uc002hnm.2	-	22	2926	c.2735C>A	c.(2734-2736)CCC>CAC	p.P912H	ACACA_uc002hnk.2_Missense_Mutation_p.P834H|ACACA_uc002hnl.2_Missense_Mutation_p.P854H|ACACA_uc002hnn.2_Missense_Mutation_p.P912H|ACACA_uc002hno.2_Missense_Mutation_p.P949H|ACACA_uc010cuz.2_Missense_Mutation_p.P912H	NM_198836	NP_942133	Q13085	ACACA_HUMAN	acetyl-Coenzyme A carboxylase alpha isoform 2	912					acetyl-CoA metabolic process|energy reserve metabolic process|fatty acid biosynthetic process|long-chain fatty-acyl-CoA biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|triglyceride biosynthetic process	cytosol	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			large_intestine(1)|ovary(1)	2		Breast(25;0.00157)|Ovarian(249;0.15)			Biotin(DB00121)	CTCCACATTGGGGGGAATGCG	0.468		NA											20	128					1.34e-09	1.52e-09	1	0
CACNG5	27091	broad.mit.edu	37	17	64876725	64876725	+	Missense_Mutation	SNP	T	T	G			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr17:64876725T>G	uc010wqi.1	+	4	572	c.335T>G	c.(334-336)TTC>TGC	p.F112C	CACNG5_uc002jfr.2_Missense_Mutation_p.F112C|CACNG5_uc010wqj.1_Missense_Mutation_p.F112C	NM_145811	NP_665810	Q9UF02	CCG5_HUMAN	voltage-dependent calcium channel gamma-5	112	Helical; (Potential).				regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|postsynaptic density|postsynaptic membrane	voltage-gated calcium channel activity			pancreas(1)|skin(1)	2			BRCA - Breast invasive adenocarcinoma(6;1.61e-08)			TTCTTCATGTTCATTGGGTTT	0.512		NA											21	78					0	0	0	0
POTEC	388468	broad.mit.edu	37	18	14542833	14542833	+	Missense_Mutation	SNP	A	A	C			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr18:14542833A>C	uc010dln.2	-	1	767	c.313T>G	c.(313-315)TGC>GGC	p.C105G	POTEC_uc010xaj.1_RNA	NM_001137671	NP_001131143	B2RU33	POTEC_HUMAN	ANKRD26-like family B, member 2	105										skin(3)	3						CAGGGGAAGCAGTGACAGCAC	0.617		NA											11	147					0	0	0	0
ONECUT2	9480	broad.mit.edu	37	18	55143819	55143819	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr18:55143819C>T	uc002lgo.2	+	2	1411	c.1379C>T	c.(1378-1380)TCC>TTC	p.S460F		NM_004852	NP_004843	O95948	ONEC2_HUMAN	one cut domain, family member 2	460	Homeobox.				organ morphogenesis	nucleus	sequence-specific DNA binding			ovary(2)|central_nervous_system(1)	3		Colorectal(73;0.234)		READ - Rectum adenocarcinoma(59;0.227)|Colorectal(16;0.245)		ATCACCATTTCCCAGCAGCTG	0.582		NA											15	39					0	0	0	0
MYO1F	4542	broad.mit.edu	37	19	8618065	8618065	+	Silent	SNP	G	G	A			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr19:8618065G>A	uc002mkg.2	-	6	576	c.462C>T	c.(460-462)TTC>TTT	p.F154F	MYO1F_uc002mkh.2_Silent_p.F154F|MYO1F_uc010xkf.1_Silent_p.F154F	NM_012335	NP_036467	O00160	MYO1F_HUMAN	myosin IF	154	Myosin head-like.					unconventional myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			ovary(2)|skin(1)	3						TGGCGTTGCCGAAGGCCTCGA	0.567		NA											8	67					0	0	0	0
PBX4	80714	broad.mit.edu	37	19	19681616	19681616	+	Missense_Mutation	SNP	C	C	T	rs147300531		TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr19:19681616C>T	uc002nmy.2	-	3	221	c.220G>A	c.(220-222)GAA>AAA	p.E74K	PBX4_uc010xqz.1_RNA|PBX4_uc010xra.1_5'UTR	NM_025245	NP_079521	Q9BYU1	PBX4_HUMAN	pre-B-cell leukemia homeobox 4	74							sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			large_intestine(1)|ovary(1)	2						GGGGGATCTTCGTCTTGAATG	0.537		NA											7	65					0	0	0	0
ZNF585B	92285	broad.mit.edu	37	19	37677052	37677052	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr19:37677052C>T	uc002ofq.2	-	5	1641	c.1387G>A	c.(1387-1389)GAA>AAA	p.E463K	uc002ofp.1_5'Flank|ZNF585B_uc002ofr.1_Missense_Mutation_p.E277K	NM_152279	NP_689492	Q52M93	Z585B_HUMAN	zinc finger protein 585B	463					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			ovary(1)	1			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			TAGGGCTTTTCTCCTGTGTGA	0.368		NA											17	296					0	0	0	0
ZNF383	163087	broad.mit.edu	37	19	37726884	37726884	+	Missense_Mutation	SNP	T	T	G			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr19:37726884T>G	uc002oft.1	+	7	720	c.140T>G	c.(139-141)CTT>CGT	p.L47R	ZNF383_uc002ofs.1_5'UTR|ZNF383_uc002ofu.1_Missense_Mutation_p.L47R	NM_152604	NP_689817	Q8NA42	ZN383_HUMAN	zinc finger protein 383	47	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			ovary(1)|skin(1)	2			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			TGAGCAGGACTTTACACTCCT	0.483		NA											9	153					0	0	0	0
SLC17A7	57030	broad.mit.edu	37	19	49933917	49933917	+	Silent	SNP	G	G	A			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr19:49933917G>A	uc002pnp.2	-	12	1714	c.1542C>T	c.(1540-1542)GAC>GAT	p.D514D	SLC17A7_uc002pno.2_Silent_p.D176D	NM_020309	NP_064705	Q9P2U7	VGLU1_HUMAN	solute carrier family 17, member 7	514	Cytoplasmic (Potential).				glutamate secretion|neurotransmitter secretion	cell junction|clathrin sculpted glutamate transport vesicle membrane|integral to membrane|synaptic vesicle membrane|synaptosome	L-glutamate transmembrane transporter activity|sodium-dependent phosphate transmembrane transporter activity|sodium:inorganic phosphate symporter activity			ovary(1)|pancreas(1)|skin(1)	3		all_lung(116;1.62e-07)|Lung NSC(112;8.47e-07)|all_neural(266;0.0381)|Ovarian(192;0.0392)		OV - Ovarian serous cystadenocarcinoma(262;0.00153)|GBM - Glioblastoma multiforme(486;0.0245)		CAGCCAGCTGGTCATGGCCAA	0.627		NA											11	47					0	0	0	0
PXDN	7837	broad.mit.edu	37	2	1653341	1653341	+	Silent	SNP	G	G	A			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr2:1653341G>A	uc002qxa.2	-	17	2275	c.2211C>T	c.(2209-2211)TTC>TTT	p.F737F		NM_012293	NP_036425	Q92626	PXDN_HUMAN	peroxidasin precursor	737					extracellular matrix organization|hydrogen peroxide catabolic process|immune response	endoplasmic reticulum|extracellular space|proteinaceous extracellular matrix	extracellular matrix structural constituent|heme binding|interleukin-1 receptor antagonist activity|peroxidase activity			pancreas(6)|ovary(2)	8	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.0845)|Lung NSC(108;0.00641)|all_epithelial(98;0.00716)		all cancers(51;0.0492)|OV - Ovarian serous cystadenocarcinoma(76;0.0973)|Epithelial(75;0.17)|GBM - Glioblastoma multiforme(21;0.228)		ACTTCTGGTGGAAGCACATGT	0.612		NA											24	87					0	0	0	0
PXDN	7837	broad.mit.edu	37	2	1664729	1664729	+	Silent	SNP	T	T	C			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr2:1664729T>C	uc002qxa.2	-	14	1825	c.1761A>G	c.(1759-1761)GCA>GCG	p.A587A	PXDN_uc002qxb.1_Silent_p.A587A	NM_012293	NP_036425	Q92626	PXDN_HUMAN	peroxidasin precursor	587	Ig-like C2-type 4.				extracellular matrix organization|hydrogen peroxide catabolic process|immune response	endoplasmic reticulum|extracellular space|proteinaceous extracellular matrix	extracellular matrix structural constituent|heme binding|interleukin-1 receptor antagonist activity|peroxidase activity			pancreas(6)|ovary(2)	8	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.0845)|Lung NSC(108;0.00641)|all_epithelial(98;0.00716)		all cancers(51;0.0492)|OV - Ovarian serous cystadenocarcinoma(76;0.0973)|Epithelial(75;0.17)|GBM - Glioblastoma multiforme(21;0.228)		GACCTGCGTCTGCAGGGCCAA	0.522		NA											10	32					0	0	0	0
APOB	338	broad.mit.edu	37	2	21231328	21231328	+	Silent	SNP	G	G	A			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr2:21231328G>A	uc002red.2	-	26	8540	c.8412C>T	c.(8410-8412)CTC>CTT	p.L2804L		NM_000384	NP_000375	P04114	APOB_HUMAN	apolipoprotein B precursor	2804					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			ovary(11)|skin(9)|central_nervous_system(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	AATCAAAATTGAGAACTTCTA	0.448		NA											30	114					0	0	0	0
CCDC121	79635	broad.mit.edu	37	2	27850176	27850176	+	Missense_Mutation	SNP	A	A	G			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr2:27850176A>G	uc002rle.2	-	2	672	c.491T>C	c.(490-492)CTA>CCA	p.L164P	ZNF512_uc010yly.1_Intron|CCDC121_uc010eze.2_Missense_Mutation_p.L328P|CCDC121_uc002rld.2_Missense_Mutation_p.L326P|GPN1_uc010ezf.2_5'Flank|GPN1_uc010yma.1_5'Flank|GPN1_uc010ymb.1_5'Flank|GPN1_uc010ymc.1_5'Flank|GPN1_uc010ymd.1_5'Flank|GPN1_uc010yme.1_5'Flank|GPN1_uc010ezg.1_5'Flank	NM_024584	NP_078860	Q6ZUS5	CC121_HUMAN	coiled-coil domain containing 121 isoform 3	164	Potential.										0	Acute lymphoblastic leukemia(172;0.155)					CTTTCCCAGTAGCCTCCTGTC	0.483		NA											24	84					0	0	0	0
C2orf42	54980	broad.mit.edu	37	2	70408542	70408542	+	Silent	SNP	T	T	C			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr2:70408542T>C	uc002sgh.2	-	3	904	c.576A>G	c.(574-576)AAA>AAG	p.K192K		NM_017880	NP_060350	Q9NWW7	CB042_HUMAN	hypothetical protein LOC54980	192											0						TTGCCTTGCATTTCACCACCA	0.512		NA											14	102					0	0	0	0
TSGA10	80705	broad.mit.edu	37	2	99720536	99720536	+	Missense_Mutation	SNP	T	T	C			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr2:99720536T>C	uc002szg.3	-	8	1133	c.505A>G	c.(505-507)AAG>GAG	p.K169E	TSGA10_uc002szh.3_Missense_Mutation_p.K169E|TSGA10_uc002szi.3_Missense_Mutation_p.K169E|TSGA10_uc010fin.1_Missense_Mutation_p.K169E|TSGA10_uc010yvn.1_Missense_Mutation_p.K169E	NM_182911	NP_878915	Q9BZW7	TSG10_HUMAN	testis specific, 10	169					spermatogenesis	cytoplasm|nuclear membrane				ovary(1)|central_nervous_system(1)	2						ATGGTTTCCTTCATCAAAGTC	0.363		NA											22	55					0	0	0	0
IL18RAP	8807	broad.mit.edu	37	2	103068292	103068292	+	Missense_Mutation	SNP	A	A	G			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr2:103068292A>G	uc002tbx.2	+	12	1935	c.1451A>G	c.(1450-1452)AAC>AGC	p.N484S	IL18RAP_uc010fiz.2_Missense_Mutation_p.N342S	NM_003853	NP_003844	O95256	I18RA_HUMAN	interleukin 18 receptor accessory protein	484	TIR.|Cytoplasmic (Potential).				cell surface receptor linked signaling pathway|inflammatory response|innate immune response	integral to membrane	transmembrane receptor activity			skin(3)|ovary(2)	5						TTGAGCCCCAACTATGTCAAT	0.353		NA											12	86					0	0	0	0
CLASP1	23332	broad.mit.edu	37	2	122155929	122155929	+	Missense_Mutation	SNP	A	A	G			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr2:122155929A>G	uc002tnc.2	-	28	3338	c.2948T>C	c.(2947-2949)ATT>ACT	p.I983T	CLASP1_uc010yyv.1_Missense_Mutation_p.I68T|CLASP1_uc002tmz.2_Missense_Mutation_p.I68T|CLASP1_uc002tna.2_Missense_Mutation_p.I68T|CLASP1_uc010yyw.1_RNA|CLASP1_uc002tnb.2_RNA|CLASP1_uc010yyx.1_RNA|CLASP1_uc010yyy.1_RNA|CLASP1_uc010yyz.1_Missense_Mutation_p.I963T|CLASP1_uc010yza.1_Missense_Mutation_p.I955T|CLASP1_uc010yzb.1_RNA|CLASP1_uc010yzc.1_RNA	NM_015282	NP_056097	Q7Z460	CLAP1_HUMAN	CLIP-associating protein 1 isoform 1	983	HEAT 5.				axon guidance|cell division|establishment or maintenance of cell polarity|exit from mitosis|G2/M transition of mitotic cell cycle|microtubule anchoring|microtubule bundle formation|microtubule nucleation|microtubule organizing center organization|mitotic prometaphase|negative regulation of microtubule depolymerization	centrosomal corona|condensed chromosome kinetochore|cortical microtubule cytoskeleton|cytoplasmic microtubule|cytosol|Golgi apparatus|kinetochore microtubule	kinetochore binding|microtubule plus-end binding			ovary(1)|central_nervous_system(1)	2	Renal(3;0.0496)					TTGATCCACAATAAATCTCAT	0.269		NA											3	3					0	0	0	0
LCT	3938	broad.mit.edu	37	2	136566291	136566291	+	Missense_Mutation	SNP	T	T	G			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr2:136566291T>G	uc002tuu.1	-	8	3637	c.3626A>C	c.(3625-3627)TAC>TCC	p.Y1209S		NM_002299	NP_002290	P09848	LPH_HUMAN	lactase-phlorizin hydrolase preproprotein	1209	3.|Extracellular (Potential).|4 X approximate repeats.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|integral to plasma membrane|membrane fraction	cation binding|glycosylceramidase activity|lactase activity			ovary(7)|central_nervous_system(2)|skin(2)|pancreas(1)|lung(1)	13				BRCA - Breast invasive adenocarcinoma(221;0.169)		TCTGGAGTAGTACGTGTTGAG	0.577		NA											45	96					0	0	0	0
LRP1B	53353	broad.mit.edu	37	2	141533735	141533735	+	Missense_Mutation	SNP	G	G	T			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr2:141533735G>T	uc002tvj.1	-	33	6404	c.5432C>A	c.(5431-5433)CCC>CAC	p.P1811H		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	1811	Extracellular (Potential).|LDL-receptor class B 18.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		TAGGATGGTGGGGTTTCTTCC	0.408		NA								TSP Lung(27;0.18)			14	31					3.27e-08	3.65e-08	1	0
FMNL2	114793	broad.mit.edu	37	2	153471451	153471451	+	Silent	SNP	A	A	G			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr2:153471451A>G	uc002tye.2	+	12	1516	c.1149A>G	c.(1147-1149)GAA>GAG	p.E383E		NM_052905	NP_443137	Q96PY5	FMNL2_HUMAN	formin-like 2	383	GBD/FH3.				actin cytoskeleton organization	cytoplasm	actin binding|Rho GTPase binding			central_nervous_system(2)|ovary(1)	3						CTCTACTGGAAGATGCTGAAA	0.398		NA											13	40					0	0	0	0
BAZ2B	29994	broad.mit.edu	37	2	160204060	160204060	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr2:160204060C>G	uc002uao.2	-	31	5743	c.5391G>C	c.(5389-5391)TTG>TTC	p.L1797F	BAZ2B_uc002uap.2_Missense_Mutation_p.L1761F	NM_013450	NP_038478	Q9UIF8	BAZ2B_HUMAN	bromodomain adjacent to zinc finger domain, 2B	1797					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(3)|skin(1)	4						GAAGGACACTCAAATCCATTT	0.353		NA											3	56					0	0	0	0
COBLL1	22837	broad.mit.edu	37	2	165557131	165557131	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr2:165557131G>C	uc010zcw.1	-	13	1800	c.1676C>G	c.(1675-1677)ACA>AGA	p.T559R	COBLL1_uc002ucp.2_Missense_Mutation_p.T493R|COBLL1_uc002ucq.2_Missense_Mutation_p.T454R|COBLL1_uc010zcx.1_Missense_Mutation_p.T500R|COBLL1_uc002ucs.1_RNA|COBLL1_uc002ucn.2_5'Flank|COBLL1_uc002uco.2_Missense_Mutation_p.T223R	NM_014900	NP_055715	Q53SF7	COBL1_HUMAN	COBL-like 1	531										ovary(2)|pancreas(1)	3						ATTTTTCAGTGTATTTATTAT	0.373		NA											12	87					0	0	0	0
TTN	7273	broad.mit.edu	37	2	179433970	179433970	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr2:179433970C>T	uc010zfg.1	-	275	69409	c.69185G>A	c.(69184-69186)GGA>GAA	p.G23062E	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.G16757E|TTN_uc010zfi.1_Missense_Mutation_p.G16690E|TTN_uc010zfj.1_Missense_Mutation_p.G16565E	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	23989							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TATTTTGGATCCCCCATCCAA	0.393		NA											20	416					0	0	0	0
TTN	7273	broad.mit.edu	37	2	179457754	179457754	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr2:179457754C>T	uc010zfg.1	-	249	51612	c.51388G>A	c.(51388-51390)GAT>AAT	p.D17130N	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.D10825N|TTN_uc010zfi.1_Missense_Mutation_p.D10758N|TTN_uc010zfj.1_Missense_Mutation_p.D10633N	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	18057							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CAAGTTAGATCGACTGAATTG	0.393		NA											7	216					0	0	0	0
TTN	7273	broad.mit.edu	37	2	179640277	179640277	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr2:179640277G>A	uc010zfg.1	-	28	6538	c.6314C>T	c.(6313-6315)CCA>CTA	p.P2105L	TTN_uc010zfh.1_Missense_Mutation_p.P2059L|TTN_uc010zfi.1_Missense_Mutation_p.P2059L|TTN_uc010zfj.1_Missense_Mutation_p.P2059L|TTN_uc002unb.2_Missense_Mutation_p.P2105L|uc002unc.1_5'Flank	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	2105							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTCGGGGTCTGGTTTCCCCAC	0.478		NA											5	96					0	0	0	0
DNAJC10	54431	broad.mit.edu	37	2	183616441	183616441	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr2:183616441G>A	uc002uow.1	+	15	1778	c.1363G>A	c.(1363-1365)GTT>ATT	p.V455I	DNAJC10_uc002uox.1_RNA|DNAJC10_uc002uoy.1_RNA|DNAJC10_uc002uoz.1_Missense_Mutation_p.V409I|DNAJC10_uc010fro.1_RNA	NM_018981	NP_061854	Q8IXB1	DJC10_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 10	455	Thioredoxin 2.				apoptosis in response to endoplasmic reticulum stress|cell redox homeostasis|ER-associated protein catabolic process|glycerol ether metabolic process|negative regulation of protein phosphorylation|protein folding|response to endoplasmic reticulum stress	endoplasmic reticulum chaperone complex|endoplasmic reticulum lumen|extracellular region	ATPase activator activity|ATPase binding|chaperone binding|electron carrier activity|heat shock protein binding|misfolded protein binding|protein disulfide oxidoreductase activity|unfolded protein binding			ovary(1)|large_intestine(1)|breast(1)|skin(1)	4			OV - Ovarian serous cystadenocarcinoma(117;0.0942)|Epithelial(96;0.209)			GAATTCTCATGTTACCACGCT	0.353		NA											20	276					0	0	0	0
NCKAP1	10787	broad.mit.edu	37	2	183845983	183845983	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr2:183845983C>G	uc002upc.2	-	13	1732	c.1330G>C	c.(1330-1332)GAA>CAA	p.E444Q	NCKAP1_uc002upb.2_Missense_Mutation_p.E450Q	NM_013436	NP_038464	Q9Y2A7	NCKP1_HUMAN	NCK-associated protein 1 isoform 1	444					apoptosis|central nervous system development	integral to membrane|lamellipodium membrane	protein binding			ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(117;0.0942)|Epithelial(96;0.209)			TGCACGAGTTCATTGAGGACA	0.383		NA											5	110					0	0	0	0
NCKAP1	10787	broad.mit.edu	37	2	183866755	183866755	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr2:183866755G>C	uc002upc.2	-	6	931	c.529C>G	c.(529-531)CGC>GGC	p.R177G	NCKAP1_uc002upb.2_Missense_Mutation_p.R183G	NM_013436	NP_038464	Q9Y2A7	NCKP1_HUMAN	NCK-associated protein 1 isoform 1	177					apoptosis|central nervous system development	integral to membrane|lamellipodium membrane	protein binding			ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(117;0.0942)|Epithelial(96;0.209)			TGGCCAAGGCGTGGGTATTCT	0.363		NA											6	108					0	0	0	0
ZNF142	7701	broad.mit.edu	37	2	219507041	219507041	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr2:219507041G>C	uc002vin.2	-	8	4634	c.4198C>G	c.(4198-4200)CTG>GTG	p.L1400V	ZNF142_uc002vil.2_Missense_Mutation_p.L1361V|ZNF142_uc010fvt.2_Missense_Mutation_p.L1237V|ZNF142_uc002vim.2_Missense_Mutation_p.L1237V	NM_001105537	NP_001099007	P52746	ZN142_HUMAN	zinc finger protein 142	1400	C2H2-type 23.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|ovary(1)|skin(1)	4		Renal(207;0.0474)		Epithelial(149;5.21e-07)|all cancers(144;0.000106)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)		TGCTGTTCCAGGTAGTGCTTT	0.612		NA											17	43					0	0	0	0
SLC4A3	6508	broad.mit.edu	37	2	220494312	220494312	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr2:220494312G>A	uc002vmp.3	+	5	775	c.506G>A	c.(505-507)GGA>GAA	p.G169E	SLC4A3_uc002vmn.2_Missense_Mutation_p.G169E|SLC4A3_uc002vmo.3_Missense_Mutation_p.G169E|SLC4A3_uc010fwm.2_5'UTR|SLC4A3_uc010fwn.1_5'Flank	NM_005070	NP_005061	P48751	B3A3_HUMAN	solute carrier family 4, anion exchanger, member	169	Cytoplasmic.				bicarbonate transport	integral to plasma membrane|membrane fraction	inorganic anion exchanger activity			ovary(2)|upper_aerodigestive_tract(1)|breast(1)|skin(1)	5		Renal(207;0.0183)		Epithelial(149;2.53e-07)|all cancers(144;5.57e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		TTCTCCATTGGAAGTGACGAG	0.637		NA											13	22					0	0	0	0
FARP2	9855	broad.mit.edu	37	2	242401976	242401976	+	Silent	SNP	G	G	A			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr2:242401976G>A	uc002wbi.1	+	15	1743	c.1626G>A	c.(1624-1626)GAG>GAA	p.E542E	FARP2_uc010zoq.1_Silent_p.E542E|FARP2_uc010zor.1_Silent_p.E542E	NM_014808	NP_055623	O94887	FARP2_HUMAN	FERM, RhoGEF and pleckstrin domain protein 2	542	DH.				axon guidance|neuron remodeling|Rac protein signal transduction|regulation of Rho protein signal transduction	cytoskeleton|cytosol|extrinsic to membrane	cytoskeletal protein binding|Rho guanyl-nucleotide exchange factor activity			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3		all_cancers(19;4.88e-34)|all_epithelial(40;4.81e-14)|Breast(86;0.000141)|Renal(207;0.0143)|all_lung(227;0.0344)|Lung NSC(271;0.0886)|Ovarian(221;0.0905)|Esophageal squamous(248;0.131)|all_hematologic(139;0.182)|Melanoma(123;0.238)		Epithelial(32;1.81e-33)|all cancers(36;1.61e-30)|OV - Ovarian serous cystadenocarcinoma(60;6.83e-15)|Kidney(56;1.19e-08)|KIRC - Kidney renal clear cell carcinoma(57;8.98e-08)|BRCA - Breast invasive adenocarcinoma(100;1.49e-06)|Lung(119;0.000152)|LUSC - Lung squamous cell carcinoma(224;0.00125)|Colorectal(34;0.0199)|COAD - Colon adenocarcinoma(134;0.121)		TAGTCAAAGAGATTCTCGCTA	0.453		NA											9	50					0	0	0	0
NINL	22981	broad.mit.edu	37	20	25477346	25477346	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr20:25477346C>T	uc002wux.1	-	10	1337	c.1263G>A	c.(1261-1263)ATG>ATA	p.M421I	NINL_uc010gdn.1_Missense_Mutation_p.M421I|NINL_uc010gdo.1_Missense_Mutation_p.M204I|NINL_uc010ztf.1_Missense_Mutation_p.M437I	NM_025176	NP_079452	Q9Y2I6	NINL_HUMAN	ninein-like	421	Potential.				G2/M transition of mitotic cell cycle	cytosol|microtubule|microtubule organizing center	calcium ion binding			ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	5						GGCAGTCGTCCATCTCTTTCA	0.602		NA											6	37					0	0	0	0
ERG	2078	broad.mit.edu	37	21	39947591	39947591	+	Missense_Mutation	SNP	T	T	C			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr21:39947591T>C	uc010gnw.2	-	3	329	c.34A>G	c.(34-36)ATC>GTC	p.I12V	ERG_uc010gnv.2_Translation_Start_Site|ERG_uc010gnx.2_Missense_Mutation_p.I12V|ERG_uc011ael.1_Missense_Mutation_p.I12V|ERG_uc002yxb.2_Missense_Mutation_p.I12V|ERG_uc002yxc.3_Missense_Mutation_p.I12V|ERG_uc010gnz.2_RNA	NM_001136155	NP_001129627	P11308	ERG_HUMAN	ets-related isoform 4	12					cell proliferation|multicellular organismal development|protein phosphorylation	cytoplasm|nucleus|ribonucleoprotein complex	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|signal transducer activity		TMPRSS2/ERG(2499)|FUS/ERG(163)|EWSR1/ERG(162)	prostate(2499)|bone(167)|haematopoietic_and_lymphoid_tissue(153)|soft_tissue(5)|lung(2)|skin(1)|ovary(1)	2828		Prostate(19;3.6e-06)				CTTACCTTGATATGAGCTGCT	0.507		NA											3	29					0	0	0	0
DSCAM	1826	broad.mit.edu	37	21	41496129	41496129	+	Missense_Mutation	SNP	T	T	C			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr21:41496129T>C	uc002yyq.1	-	20	4141	c.3689A>G	c.(3688-3690)TAT>TGT	p.Y1230C	DSCAM_uc002yyr.1_RNA	NM_001389	NP_001380	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule isoform	1230	Fibronectin type-III 4.|Extracellular (Potential).				cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			ovary(6)|skin(4)|upper_aerodigestive_tract(1)	11		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				TACTGTGGGATAGGGGTGGGA	0.552		NA											15	133					0	0	0	0
DSCAM	1826	broad.mit.edu	37	21	41711195	41711195	+	Missense_Mutation	SNP	T	T	C			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr21:41711195T>C	uc002yyq.1	-	7	1810	c.1358A>G	c.(1357-1359)CAC>CGC	p.H453R	DSCAM_uc002yyr.1_RNA	NM_001389	NP_001380	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule isoform	453	Extracellular (Potential).|Ig-like C2-type 5.				cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			ovary(6)|skin(4)|upper_aerodigestive_tract(1)	11		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				GCTGATGCGGTGACTGCCACC	0.607		NA											3	36					0	0	0	0
PFKL	5211	broad.mit.edu	37	21	45730967	45730967	+	Splice_Site	SNP	G	G	T			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr21:45730967G>T	uc002zel.2	+	3	296	c.237_splice	c.e3+1	p.L79_splice	PFKL_uc002zek.2_Splice_Site_p.L126_splice|PFKL_uc011afd.1_Splice_Site_p.L126_splice	NM_002626	NP_002617	P17858	K6PL_HUMAN	liver phosphofructokinase						fructose 6-phosphate metabolic process|glycolysis|protein oligomerization	6-phosphofructokinase complex	6-phosphofructokinase activity|ATP binding|fructose-6-phosphate binding|identical protein binding|kinase binding|metal ion binding				0				Colorectal(79;0.0811)		CATCCAGCTGGTGAGGCCTGG	0.483		NA											6	20					3.6e-05	3.91e-05	1	0
GGTLC2	91227	broad.mit.edu	37	22	22988944	22988944	+	Silent	SNP	C	C	G			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr22:22988944C>G	uc010gtt.2	+	1	163	c.129C>G	c.(127-129)GTC>GTG	p.V43V	LOC96610_uc011aim.1_Intron|POM121L1P_uc011ait.1_5'Flank|GGTLC2_uc010gts.2_Silent_p.V43V	NM_199127	NP_954578	Q14390	GGTL2_HUMAN	gamma-glutamyltransferase-like 4 isoform 1	43					glutathione biosynthetic process		gamma-glutamyltransferase activity			ovary(1)	1	all_hematologic(9;0.0135)|Acute lymphoblastic leukemia(84;0.17)	all_hematologic(6;1.3e-31)|Acute lymphoblastic leukemia(6;5.54e-23)		READ - Rectum adenocarcinoma(21;0.145)		TGTCTGTCGTCGCAGAGGACG	0.652		NA											2	7					0	0	0	0
SFI1	9814	broad.mit.edu	37	22	32011159	32011159	+	Nonsense_Mutation	SNP	C	C	G			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr22:32011159C>G	uc003ale.2	+	29	3587	c.3194C>G	c.(3193-3195)TCA>TGA	p.S1065*	SFI1_uc003alf.2_Nonsense_Mutation_p.S1034*|SFI1_uc003alg.2_Nonsense_Mutation_p.S983*|SFI1_uc011alp.1_Nonsense_Mutation_p.S971*|SFI1_uc011alq.1_Nonsense_Mutation_p.S1010*|SFI1_uc003alh.2_RNA|SFI1_uc010gwi.2_RNA|SFI1_uc003ali.2_Nonsense_Mutation_p.S157*|SFI1_uc003alj.2_Nonsense_Mutation_p.S199*	NM_001007467	NP_001007468	A8K8P3	SFI1_HUMAN	spindle assembly associated Sfi1 homolog isoform	1065					G2/M transition of mitotic cell cycle	centriole|cytosol				central_nervous_system(1)	1						GGGGCCCTGTCAAGCGCCCCT	0.716		NA											6	29					0	0	0	0
SLC5A4	6527	broad.mit.edu	37	22	32650129	32650129	+	Silent	SNP	C	C	T			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr22:32650129C>T	uc003ami.2	-	2	209	c.207G>A	c.(205-207)CCG>CCA	p.P69P		NM_014227	NP_055042	Q9NY91	SC5A4_HUMAN	solute carrier family 5 (low affinity glucose	69	Helical; (Potential).				carbohydrate transport|sodium ion transport	integral to membrane	symporter activity				0						ATCCACTTACCGGCCACCAGG	0.403		NA											29	35					0	0	0	0
ZIC1	7545	broad.mit.edu	37	3	147128517	147128517	+	Silent	SNP	G	G	A			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr3:147128517G>A	uc003ewe.2	+	1	1337	c.618G>A	c.(616-618)GCG>GCA	p.A206A		NM_003412	NP_003403	Q15915	ZIC1_HUMAN	zinc finger protein of the cerebellum 1	206					behavior|brain development|cell differentiation|inner ear morphogenesis|pattern specification process|positive regulation of protein import into nucleus|positive regulation of transcription, DNA-dependent|regulation of smoothened signaling pathway	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2						ACATGGCCGCGCATCACGGCG	0.652		NA											14	48					0	0	0	0
SI	6476	broad.mit.edu	37	3	164741544	164741544	+	Silent	SNP	T	T	A			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr3:164741544T>A	uc003fei.2	-	26	2975	c.2913A>T	c.(2911-2913)GCA>GCT	p.A971A		NM_001041	NP_001032	P14410	SUIS_HUMAN	sucrase-isomaltase	971	Lumenal.|P-type 2.|Isomaltase.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			ovary(7)|upper_aerodigestive_tract(4)|skin(2)|pancreas(1)	14		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	AACACTCAGGTGCTTTGGATA	0.363		NA								HNSCC(35;0.089)			18	90					0	0	0	0
EVC	2121	broad.mit.edu	37	4	5755517	5755517	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr4:5755517G>A	uc003gil.1	+	10	1505	c.1321G>A	c.(1321-1323)GTC>ATC	p.V441I	EVC_uc003gim.1_RNA|CRMP1_uc003gin.1_Intron	NM_153717	NP_714928	P57679	EVC_HUMAN	Ellis van Creveld syndrome protein	441					muscle organ development	integral to membrane				ovary(1)|skin(1)	2		Myeloproliferative disorder(84;0.117)				CCCAGAGTTTGTCCAGCGAGG	0.552		NA											5	91					0	0	0	0
ZNF518B	85460	broad.mit.edu	37	4	10444982	10444982	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr4:10444982G>A	uc003gmn.2	-	3	3458	c.2971C>T	c.(2971-2973)CGC>TGC	p.R991C		NM_053042	NP_444270	Q9C0D4	Z518B_HUMAN	zinc finger protein 518B	991					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)|upper_aerodigestive_tract(1)	4						TAGGTCAGGCGTACATGATGC	0.383		NA											16	51					0	0	0	0
IRF2	3660	broad.mit.edu	37	4	185340660	185340660	+	Silent	SNP	T	T	C			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr4:185340660T>C	uc003iwf.3	-	3	350	c.150A>G	c.(148-150)AAA>AAG	p.K50K		NM_002199	NP_002190	P14316	IRF2_HUMAN	interferon regulatory factor 2	50	IRF tryptophan pentad repeat.				blood coagulation|cell proliferation|interferon-gamma-mediated signaling pathway|negative regulation of transcription from RNA polymerase II promoter|type I interferon-mediated signaling pathway	focal adhesion|nucleoplasm	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1		all_lung(41;7.86e-14)|Lung NSC(41;1.87e-13)|Colorectal(36;0.00146)|Hepatocellular(41;0.00826)|Renal(120;0.00992)|Prostate(90;0.0115)|all_neural(102;0.0573)|all_hematologic(60;0.0592)		all cancers(43;3.94e-27)|Epithelial(43;5.3e-24)|OV - Ovarian serous cystadenocarcinoma(60;1.06e-10)|Colorectal(24;7.98e-07)|STAD - Stomach adenocarcinoma(60;3.95e-05)|GBM - Glioblastoma multiforme(59;8.3e-05)|COAD - Colon adenocarcinoma(29;0.000106)|BRCA - Breast invasive adenocarcinoma(30;0.000311)|LUSC - Lung squamous cell carcinoma(40;0.0128)|READ - Rectum adenocarcinoma(43;0.0419)		GTGGTGCATCTTTTTCCACAT	0.398		NA											11	82					0	0	0	0
ADCY2	108	broad.mit.edu	37	5	7695903	7695903	+	Missense_Mutation	SNP	C	C	A			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr5:7695903C>A	uc003jdz.1	+	6	975	c.908C>A	c.(907-909)GCA>GAA	p.A303E	ADCY2_uc011cmo.1_Missense_Mutation_p.A123E	NM_020546	NP_065433	Q08462	ADCY2_HUMAN	adenylate cyclase 2	303	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	cytoplasm|dendrite|integral to membrane|plasma membrane	ATP binding|metal ion binding			ovary(5)|pancreas(1)|skin(1)	7						ACCCGGCTGGCAAGTGACTGC	0.428		NA											15	14					2.32e-09	2.62e-09	1	0
SEMA5A	9037	broad.mit.edu	37	5	9224908	9224908	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr5:9224908G>C	uc003jek.2	-	8	1236	c.524C>G	c.(523-525)GCT>GGT	p.A175G		NM_003966	NP_003957	Q13591	SEM5A_HUMAN	semaphorin 5A precursor	175	Sema.|Extracellular (Potential).				cell adhesion|cell-cell signaling	integral to membrane|plasma membrane				ovary(1)|central_nervous_system(1)	2						CTCCCCACCAGCTGTGAGGAG	0.572		NA											15	19					0	0	0	0
RICTOR	253260	broad.mit.edu	37	5	38950400	38950400	+	Missense_Mutation	SNP	T	T	G			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr5:38950400T>G	uc003jlp.2	-	31	3574	c.3550A>C	c.(3550-3552)AAA>CAA	p.K1184Q	RICTOR_uc003jlo.2_Missense_Mutation_p.K1184Q|RICTOR_uc010ivf.2_Missense_Mutation_p.K899Q	NM_152756	NP_689969	Q6R327	RICTR_HUMAN	rapamycin-insensitive companion of mTOR	1184					actin cytoskeleton reorganization|embryo development|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of TOR signaling cascade|regulation of protein kinase B signaling cascade|T cell costimulation	cytosol|TORC2 complex	protein binding			ovary(3)|lung(3)|skin(2)|kidney(1)|central_nervous_system(1)	10	all_lung(31;0.000396)					TTGGTGAATTTTAAGTCATTT	0.368		NA											29	137					0	0	0	0
CCNB1	891	broad.mit.edu	37	5	68467126	68467126	+	Missense_Mutation	SNP	A	A	C			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr5:68467126A>C	uc003jvm.2	+	4	570	c.393A>C	c.(391-393)GAA>GAC	p.E131D	CCNB1_uc011crd.1_Missense_Mutation_p.E131D|CCNB1_uc010ixb.2_Missense_Mutation_p.E131D	NM_031966	NP_114172	P14635	CCNB1_HUMAN	cyclin B1	131					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|G1/S transition of mitotic cell cycle|G2/M transition of mitotic cell cycle|mitotic cell cycle spindle checkpoint|mitotic metaphase plate congression|mitotic prometaphase|mitotic spindle stabilization|positive regulation of attachment of spindle microtubules to kinetochore|positive regulation of mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of cyclin-dependent protein kinase activity	condensed nuclear chromosome outer kinetochore|cytosol|microtubule organizing center|nucleoplasm|spindle pole					0		Lung NSC(167;5.51e-05)|Prostate(74;0.00634)|Ovarian(174;0.0448)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;1.24e-56)|Epithelial(20;1.12e-52)|all cancers(19;2.63e-48)|Lung(70;0.0177)		GCCCAATGGAAACATCTGGAT	0.423		NA											3	46					0	0	0	0
FER	2241	broad.mit.edu	37	5	108233448	108233448	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr5:108233448G>C	uc003kop.1	+	10	1519	c.1135G>C	c.(1135-1137)GCA>CCA	p.A379P	FER_uc011cvf.1_Intron|FER_uc011cvg.1_Missense_Mutation_p.A204P	NM_005246	NP_005237	P16591	FER_HUMAN	fer (fps/fes related) tyrosine kinase	379	Potential.				intracellular signal transduction|peptidyl-tyrosine phosphorylation	cytoplasm|nucleus	ATP binding|non-membrane spanning protein tyrosine kinase activity			lung(2)|stomach(1)|ovary(1)|kidney(1)	5		all_cancers(142;2.86e-06)|all_epithelial(76;9.81e-08)|Prostate(80;0.00972)|Lung NSC(167;0.039)|Ovarian(225;0.0448)|all_lung(232;0.0496)|Colorectal(57;0.0986)|Breast(839;0.152)		OV - Ovarian serous cystadenocarcinoma(64;6.77e-10)|Epithelial(69;4.13e-08)|COAD - Colon adenocarcinoma(37;0.0174)		AAAGTTTTCAGCACAGAAGGA	0.398		NA											4	23					0	0	0	0
PCDHA1	56147	broad.mit.edu	37	5	140167440	140167440	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr5:140167440C>T	uc003lhb.2	+	1	1565	c.1565C>T	c.(1564-1566)CCC>CTC	p.P522L	PCDHA1_uc003lha.2_Missense_Mutation_p.P522L|PCDHA1_uc003lgz.2_Missense_Mutation_p.P522L	NM_018900	NP_061723	Q9Y5I3	PCDA1_HUMAN	protocadherin alpha 1 isoform 1 precursor	522	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	extracellular region|integral to plasma membrane	calcium ion binding|protein binding			skin(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCACTGCAGCCCCTGGACCAC	0.677		NA											39	35					0	0	0	0
DOCK2	1794	broad.mit.edu	37	5	169508940	169508940	+	Missense_Mutation	SNP	C	C	A			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr5:169508940C>A	uc003maf.2	+	51	5462	c.5382C>A	c.(5380-5382)GAC>GAA	p.D1794E	DOCK2_uc011der.1_RNA|DOCK2_uc010jjm.2_Missense_Mutation_p.D1286E|DOCK2_uc003mah.2_Missense_Mutation_p.D350E	NM_004946	NP_004937	Q92608	DOCK2_HUMAN	dedicator of cytokinesis 2	1794					actin cytoskeleton organization|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|endomembrane system|membrane	electron carrier activity|GTP binding|GTPase binding|heme binding|Rac guanyl-nucleotide exchange factor activity|T cell receptor binding			ovary(5)|pancreas(2)	7	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			CAGATGGTGACAAGAAGACAC	0.542		NA											5	38					0.000602214	0.000643315	1	0
RANBP17	64901	broad.mit.edu	37	5	170668104	170668104	+	Silent	SNP	T	T	G			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr5:170668104T>G	uc003mba.2	+	23	2611	c.2595T>G	c.(2593-2595)GCT>GCG	p.A865A	RANBP17_uc003mbb.2_Silent_p.A190A|RANBP17_uc003mbd.2_Silent_p.A228A|RANBP17_uc010jjs.2_RNA	NM_022897	NP_075048	Q9H2T7	RBP17_HUMAN	RAN binding protein 17	865					mRNA transport|protein import into nucleus|transmembrane transport	cytoplasm|nuclear pore	GTP binding|protein transporter activity			ovary(2)|central_nervous_system(1)	3	Renal(175;0.000159)|Lung NSC(126;0.00751)|all_lung(126;0.0123)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			TACTCCAGGCTTTTGTCAAAA	0.438		NA	T	TRD@	ALL								32	96					0	0	0	0
DDX41	51428	broad.mit.edu	37	5	176939861	176939861	+	Missense_Mutation	SNP	T	T	C			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr5:176939861T>C	uc003mho.2	-	13	1340	c.1319A>G	c.(1318-1320)GAG>GGG	p.E440G	DOK3_uc003mhi.3_5'Flank|DOK3_uc003mhj.3_5'Flank|DOK3_uc003mhl.2_5'Flank|DDX41_uc003mhm.2_Missense_Mutation_p.E220G|DDX41_uc003mhn.2_Missense_Mutation_p.E309G|DDX41_uc003mhp.2_Missense_Mutation_p.E309G|DDX41_uc003mhq.1_Missense_Mutation_p.E220G	NM_016222	NP_057306	Q9UJV9	DDX41_HUMAN	DEAD-box protein abstrakt	440	Helicase C-terminal.				apoptosis|multicellular organismal development	catalytic step 2 spliceosome	ATP binding|ATP-dependent helicase activity|protein binding|RNA binding|zinc ion binding				0	all_cancers(89;0.00033)|Renal(175;0.000269)|Lung NSC(126;0.00161)|all_lung(126;0.00286)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)|Epithelial(233;0.191)			TGCCTTCTTCTCTGCAAAGAT	0.607		NA											11	68					0	0	0	0
HIST1H1T	3010	broad.mit.edu	37	6	26107762	26107762	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr6:26107762G>A	uc003ngj.2	-	1	603	c.560C>T	c.(559-561)GCT>GTT	p.A187V		NM_005323	NP_005314	P22492	H1T_HUMAN	histone cluster 1, H1t	187					cell differentiation|multicellular organismal development|nucleosome assembly|spermatogenesis	nucleosome	DNA binding			ovary(2)	2						TGACTTCGAAGCCCTTGCCTT	0.468		NA											20	99					0	0	0	0
HIST1H2AL	8332	broad.mit.edu	37	6	27833180	27833180	+	Silent	SNP	G	G	A			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr6:27833180G>A	uc003njw.2	+	1	74	c.48G>A	c.(46-48)AAG>AAA	p.K16K		NM_003511	NP_003502	P0C0S8	H2A1_HUMAN	histone cluster 1, H2al	16					nucleosome assembly	nucleosome|nucleus	DNA binding|enzyme binding				0						CCAAAGCCAAGACCCGCTCTT	0.637		NA											13	101					0	0	0	0
PGBD1	84547	broad.mit.edu	37	6	28268549	28268549	+	Silent	SNP	G	G	A			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr6:28268549G>A	uc003nky.2	+	7	1288	c.918G>A	c.(916-918)AGG>AGA	p.R306R	PGBD1_uc003nkz.2_Silent_p.R306R	NM_032507	NP_115896	Q96JS3	PGBD1_HUMAN	piggyBac transposable element derived 1	306					viral reproduction	membrane|nucleus	scavenger receptor activity|sequence-specific DNA binding transcription factor activity			ovary(4)	4						CTACTGAAAGGACAGTTGCAC	0.448		NA											4	53					0	0	0	0
OR12D3	81797	broad.mit.edu	37	6	29342160	29342160	+	Missense_Mutation	SNP	T	T	G			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr6:29342160T>G	uc003nme.2	-	1	909	c.905A>C	c.(904-906)AAA>ACA	p.K302T		NM_030959	NP_112221	Q9UGF7	O12D3_HUMAN	olfactory receptor, family 12, subfamily D,	302	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|breast(1)	3						ACCAAAGATTTTCTTCAGAGC	0.428		NA											4	132					0	0	0	0
COL11A2	1302	broad.mit.edu	37	6	33156845	33156845	+	Missense_Mutation	SNP	C	C	G	rs41268014		TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr6:33156845C>G	uc003ocx.1	-	3	581	c.353G>C	c.(352-354)CGA>CCA	p.R118P	COL11A2_uc003ocy.1_Missense_Mutation_p.R118P|COL11A2_uc003ocz.1_Missense_Mutation_p.R118P|COL11A2_uc003oda.2_Missense_Mutation_p.R118P	NM_080680	NP_542411	P13942	COBA2_HUMAN	collagen, type XI, alpha 2 isoform 1	118	TSP N-terminal.				cartilage development|cell adhesion|collagen fibril organization|sensory perception of sound|soft palate development	collagen type XI	extracellular matrix structural constituent conferring tensile strength|protein binding, bridging			ovary(3)|skin(2)	5						GCGGACAGGTCGGCCCAGCTC	0.617		NA											4	84					0	0	0	0
SLC26A8	116369	broad.mit.edu	37	6	35919038	35919038	+	Missense_Mutation	SNP	C	C	T	rs115071158	by1000genomes	TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr6:35919038C>T	uc003olm.2	-	19	2485	c.2374G>A	c.(2374-2376)GTG>ATG	p.V792M	SLC26A8_uc010jwa.2_RNA|SLC26A8_uc003olk.2_Missense_Mutation_p.V374M|SLC26A8_uc003oln.2_Missense_Mutation_p.V792M|SLC26A8_uc003oll.2_Missense_Mutation_p.V687M	NM_052961	NP_443193	Q96RN1	S26A8_HUMAN	solute carrier family 26, member 8 isoform a	792	Interaction with RACGAP1.|STAS.|Cytoplasmic (Potential).				cell differentiation|meiosis|multicellular organismal development|spermatogenesis	integral to membrane|plasma membrane	anion:anion antiporter activity|chloride channel activity|oxalate transmembrane transporter activity|protein binding|sulfate transmembrane transporter activity			ovary(2)	2						GCAAACAGCACGGCGTCGTGA	0.488		NA											12	50					0	0	0	0
TCTE1	202500	broad.mit.edu	37	6	44253954	44253954	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr6:44253954G>A	uc003oxi.2	-	3	749	c.593C>T	c.(592-594)CCG>CTG	p.P198L	SPATS1_uc003oxg.2_Intron|TMEM151B_uc003oxf.2_Intron	NM_182539	NP_872345	Q5JU00	TCTE1_HUMAN	t-complex-associated testis expressed 1	198										ovary(2)|skin(2)	4	Hepatocellular(11;0.00908)|all_lung(25;0.0101)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)			CTGCACCGGCGGAAGGAACTG	0.657		NA											6	33					0	0	0	0
MDN1	23195	broad.mit.edu	37	6	90482425	90482425	+	Silent	SNP	G	G	A			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr6:90482425G>A	uc003pnn.1	-	14	2066	c.1950C>T	c.(1948-1950)TTC>TTT	p.F650F	MDN1_uc003pno.1_Silent_p.F68F	NM_014611	NP_055426	Q9NU22	MDN1_HUMAN	MDN1, midasin homolog	650					protein complex assembly|regulation of protein complex assembly	nucleus	ATP binding|ATPase activity|unfolded protein binding			ovary(8)|skin(2)	10		all_cancers(76;1.47e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00246)		BRCA - Breast invasive adenocarcinoma(108;0.0193)		GTGTAGCAGCGAAAGTGAACT	0.498		NA											10	51					0	0	0	0
GPR63	81491	broad.mit.edu	37	6	97246956	97246956	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr6:97246956G>A	uc010kcl.2	-	3	1130	c.652C>T	c.(652-654)CCC>TCC	p.P218S	GPR63_uc003pou.2_Missense_Mutation_p.P218S	NM_001143957	NP_001137429	Q9BZJ6	GPR63_HUMAN	G protein-coupled receptor 63	218	Extracellular (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity|protein binding			upper_aerodigestive_tract(1)|ovary(1)	2		all_cancers(76;6.89e-05)|Acute lymphoblastic leukemia(125;7.02e-10)|all_hematologic(75;1.23e-06)|all_epithelial(107;0.0618)|Colorectal(196;0.0721)		BRCA - Breast invasive adenocarcinoma(108;0.0912)		TGCAGGTCGGGGTTTCCTACG	0.463		NA											11	52					0	0	0	0
SYNE1	23345	broad.mit.edu	37	6	152651117	152651117	+	Silent	SNP	C	C	T			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr6:152651117C>T	uc010kiw.2	-	78	15305	c.14703G>A	c.(14701-14703)AGG>AGA	p.R4901R	SYNE1_uc003qot.3_Silent_p.R4830R|SYNE1_uc003qou.3_Silent_p.R4901R|SYNE1_uc010kiz.2_Silent_p.R656R	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	4901	Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		CCTTCACTCTCCTCAGCCAGT	0.517		NA								HNSCC(10;0.0054)			23	59					0	0	0	0
ZNF716	441234	broad.mit.edu	37	7	57528634	57528634	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr7:57528634C>T	uc011kdi.1	+	4	579	c.467C>T	c.(466-468)ACA>ATA	p.T156I		NM_001159279	NP_001152751			zinc finger protein 716											ovary(2)	2						CAAAACAAAACATTTCAGACT	0.323		NA											6	10					0	0	0	0
ZNF804B	219578	broad.mit.edu	37	7	88963965	88963965	+	Missense_Mutation	SNP	A	A	C			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr7:88963965A>C	uc011khi.1	+	4	2207	c.1669A>C	c.(1669-1671)AGT>CGT	p.S557R		NM_181646	NP_857597	A4D1E1	Z804B_HUMAN	zinc finger protein 804B	557						intracellular	zinc ion binding			ovary(5)|skin(3)|pancreas(2)|upper_aerodigestive_tract(1)	11	all_hematologic(106;0.125)|Lung NSC(181;0.15)|all_lung(186;0.151)		STAD - Stomach adenocarcinoma(171;0.0513)			TTTGGACTACAGTGATTCTGA	0.343		NA								HNSCC(36;0.09)			7	48					0	0	0	0
TRRAP	8295	broad.mit.edu	37	7	98580905	98580905	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr7:98580905G>A	uc003upp.2	+	59	9033	c.8824G>A	c.(8824-8826)GAA>AAA	p.E2942K	TRRAP_uc011kis.1_Missense_Mutation_p.E2924K|TRRAP_uc003upr.2_Missense_Mutation_p.E2641K	NM_003496	NP_003487	Q9Y4A5	TRRAP_HUMAN	transformation/transcription domain-associated	2942	FAT.				histone deubiquitination|histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|PCAF complex|STAGA complex|transcription factor TFTC complex	phosphotransferase activity, alcohol group as acceptor|protein binding|transcription cofactor activity			ovary(9)|large_intestine(8)|central_nervous_system(6)|skin(6)|stomach(5)|upper_aerodigestive_tract(1)|lung(1)|liver(1)	37	all_cancers(62;6.96e-09)|all_epithelial(64;4.86e-09)|Lung NSC(181;0.01)|all_lung(186;0.016)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)			GCAAATCATCGAACTCCAGGA	0.517		NA											6	19					0	0	0	0
CUX1	1523	broad.mit.edu	37	7	101559503	101559503	+	Nonsense_Mutation	SNP	G	G	T			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr7:101559503G>T	uc003uyx.3	+	2	177	c.139G>T	c.(139-141)GAG>TAG	p.E47*	CUX1_uc003uys.3_Nonsense_Mutation_p.E58*|CUX1_uc003uyt.2_Nonsense_Mutation_p.E58*|CUX1_uc011kkn.1_Intron|CUX1_uc003uyw.2_Nonsense_Mutation_p.E58*|CUX1_uc003uyv.2_Nonsense_Mutation_p.E58*|CUX1_uc003uyu.2_Nonsense_Mutation_p.E58*	NM_181552	NP_853530	P39880	CUX1_HUMAN	cut-like homeobox 1 isoform a	47	Potential.				negative regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(5)|pancreas(1)|central_nervous_system(1)|skin(1)	8						GAACACTCCAGAGGTGAGGCG	0.532		NA											7	55					0.00198382	0.00209435	1	0
FBXL13	222235	broad.mit.edu	37	7	102523890	102523890	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr7:102523890G>C	uc003vaq.2	-	14	1677	c.1250C>G	c.(1249-1251)TCC>TGC	p.S417C	FBXL13_uc010liq.1_Intron|FBXL13_uc010lir.1_Missense_Mutation_p.S417C|FBXL13_uc003var.2_RNA|FBXL13_uc003vas.2_Missense_Mutation_p.S417C	NM_145032	NP_659469	Q8NEE6	FXL13_HUMAN	F-box and leucine-rich repeat protein 13 isoform	417	LRR 8.										0						AAATTTGAAGGATGCATCAGT	0.343		NA											14	37					0	0	0	0
RELN	5649	broad.mit.edu	37	7	103138354	103138354	+	Missense_Mutation	SNP	G	G	A	rs114501042	by1000genomes	TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr7:103138354G>A	uc003vca.2	-	55	9023	c.8863C>T	c.(8863-8865)CGC>TGC	p.R2955C	RELN_uc010liz.2_Missense_Mutation_p.R2955C	NM_005045	NP_005036	P78509	RELN_HUMAN	reelin isoform a	2955					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			ovary(8)|upper_aerodigestive_tract(5)|large_intestine(2)|central_nervous_system(2)|skin(1)|pancreas(1)	19				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		CTACCGATGCGCCCCCAGTAT	0.468		NA											11	37					0	0	0	0
TFEC	22797	broad.mit.edu	37	7	115580975	115580975	+	Missense_Mutation	SNP	A	A	C			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr7:115580975A>C	uc003vhj.1	-	8	858	c.674T>G	c.(673-675)ATT>AGT	p.I225S	TFEC_uc003vhk.1_Missense_Mutation_p.I196S|TFEC_uc003vhl.3_3'UTR|TFEC_uc011kmw.1_3'UTR	NM_012252	NP_036384	O14948	TFEC_HUMAN	transcription factor EC isoform a	225						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity			large_intestine(1)	1			STAD - Stomach adenocarcinoma(10;0.00878)			ACGAGCCTGAATTTCTAGTTC	0.388		NA											9	61					0	0	0	0
FEZF1	389549	broad.mit.edu	37	7	121943895	121943895	+	Silent	SNP	G	G	A			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr7:121943895G>A	uc003vkd.2	-	1	671	c.597C>T	c.(595-597)GCC>GCT	p.A199A	FEZF1_uc003vkc.2_Silent_p.A149A|uc010lko.1_RNA|uc003vkf.1_5'Flank	NM_001024613	NP_001019784	A0PJY2	FEZF1_HUMAN	FEZ family zinc finger 1 isoform 1	199					cell differentiation|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|breast(1)	3						TATTCCTTTCGGCTAAATACG	0.557		NA											4	42					0	0	0	0
GRM8	2918	broad.mit.edu	37	7	126882949	126882949	+	Missense_Mutation	SNP	C	C	G	rs147289844		TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr7:126882949C>G	uc003vlr.2	-	1	621	c.310G>C	c.(310-312)GAC>CAC	p.D104H	GRM8_uc003vls.2_RNA|GRM8_uc011kof.1_RNA|GRM8_uc003vlt.2_Missense_Mutation_p.D104H|GRM8_uc010lkz.1_RNA	NM_000845	NP_000836	O00222	GRM8_HUMAN	glutamate receptor, metabotropic 8 isoform a	104	Extracellular (Potential).				negative regulation of cAMP biosynthetic process|sensory perception of smell|visual perception	integral to plasma membrane				lung(15)|ovary(5)|pancreas(1)|breast(1)|skin(1)	23		Prostate(267;0.186)			L-Glutamic Acid(DB00142)	GAGCACGTGTCGAGGATGCGG	0.478		NA								HNSCC(24;0.065)			11	39					0	0	0	0
GRM8	2918	broad.mit.edu	37	7	126883115	126883115	+	Silent	SNP	C	C	T			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr7:126883115C>T	uc003vlr.2	-	1	455	c.144G>A	c.(142-144)TTG>TTA	p.L48L	GRM8_uc003vls.2_RNA|GRM8_uc011kof.1_RNA|GRM8_uc003vlt.2_Silent_p.L48L|GRM8_uc010lkz.1_RNA	NM_000845	NP_000836	O00222	GRM8_HUMAN	glutamate receptor, metabotropic 8 isoform a	48	Extracellular (Potential).				negative regulation of cAMP biosynthetic process|sensory perception of smell|visual perception	integral to plasma membrane				lung(15)|ovary(5)|pancreas(1)|breast(1)|skin(1)	23		Prostate(267;0.186)			L-Glutamic Acid(DB00142)	AGAGACCCCCCAAAATAATGT	0.527		NA								HNSCC(24;0.065)			13	84					0	0	0	0
ERICH1	157697	broad.mit.edu	37	8	614671	614671	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr8:614671C>T	uc003wph.2	-	6	1329	c.1264G>A	c.(1264-1266)GCC>ACC	p.A422T	ERICH1_uc011kwh.1_Intron|ERICH1_uc003wpe.1_Intron	NM_207332	NP_997215	Q86X53	ERIC1_HUMAN	glutamate-rich 1	422										large_intestine(2)	2		Colorectal(14;0.158)|Ovarian(12;0.17)|Myeloproliferative disorder(644;0.185)|Hepatocellular(245;0.236)		Epithelial(5;3.29e-14)|BRCA - Breast invasive adenocarcinoma(11;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(5;3.65e-06)|READ - Rectum adenocarcinoma(1;0.0325)		ATTACTCTGGCATGGTCTAGA	0.313		NA											4	43					0	0	0	0
TRIM35	23087	broad.mit.edu	37	8	27146779	27146779	+	Missense_Mutation	SNP	C	C	A			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr8:27146779C>A	uc003xfl.1	-	5	886	c.804G>T	c.(802-804)GAG>GAT	p.E268D	TRIM35_uc010lup.1_Missense_Mutation_p.A229S	NM_171982	NP_741983	Q9UPQ4	TRI35_HUMAN	tripartite motif-containing 35 isoform 2	268					apoptosis|induction of apoptosis|negative regulation of mitotic cell cycle	cytoplasm|nucleus	zinc ion binding				0		Ovarian(32;2.61e-05)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0213)|Epithelial(17;9.34e-10)|Colorectal(74;0.141)		CTGGCTCTGGCTCCATGGTGC	0.567		NA											3	15					0.004672	0.00487513	1	0
EYA1	2138	broad.mit.edu	37	8	72211931	72211931	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr8:72211931C>T	uc003xys.3	-	7	868	c.581G>A	c.(580-582)GGA>GAA	p.G194E	EYA1_uc003xyr.3_Missense_Mutation_p.G189E|EYA1_uc003xyt.3_Missense_Mutation_p.G161E|EYA1_uc010lzf.2_Missense_Mutation_p.G121E|EYA1_uc003xyu.2_Missense_Mutation_p.G194E|EYA1_uc011lfe.1_Missense_Mutation_p.G188E|EYA1_uc003xyv.2_Missense_Mutation_p.G72E	NM_172058	NP_742055	Q99502	EYA1_HUMAN	eyes absent 1 isoform b	194					double-strand break repair|histone dephosphorylation|positive regulation of DNA repair|protein sumoylation|regulation of transcription, DNA-dependent|response to ionizing radiation|sensory perception of sound|transcription, DNA-dependent	cytoplasm|nucleus	metal ion binding|protein tyrosine phosphatase activity			ovary(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	5	Breast(64;0.046)		Epithelial(68;0.0837)|all cancers(69;0.247)			TGTATATATTCCTGATGATGT	0.303		NA											37	55					0	0	0	0
ZFHX4	79776	broad.mit.edu	37	8	77764068	77764068	+	Silent	SNP	C	C	T			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr8:77764068C>T	uc003yav.2	+	10	5163	c.4776C>T	c.(4774-4776)AGC>AGT	p.S1592S	ZFHX4_uc003yau.1_Silent_p.S1637S|ZFHX4_uc003yaw.1_Silent_p.S1592S	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	1592						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			GTGGGCACAGCATTGCAGCAA	0.488		NA								HNSCC(33;0.089)			4	45					0	0	0	0
PTPRD	5789	broad.mit.edu	37	9	8507393	8507393	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr9:8507393C>G	uc003zkk.2	-	21	2296	c.1585G>C	c.(1585-1587)GAA>CAA	p.E529Q	PTPRD_uc003zkp.2_Missense_Mutation_p.E529Q|PTPRD_uc003zkq.2_Missense_Mutation_p.E529Q|PTPRD_uc003zkr.2_Missense_Mutation_p.E523Q|PTPRD_uc003zks.2_Missense_Mutation_p.E519Q|PTPRD_uc003zkl.2_Missense_Mutation_p.E529Q|PTPRD_uc003zkm.2_Missense_Mutation_p.E516Q|PTPRD_uc003zkn.2_Missense_Mutation_p.E529Q|PTPRD_uc003zko.2_Missense_Mutation_p.E526Q	NM_002839	NP_002830	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	529	Fibronectin type-III 3.|Extracellular (Potential).				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			lung(14)|large_intestine(3)|ovary(2)|breast(2)|urinary_tract(1)	22		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		ATACTTGTTTCAGACTCAGGT	0.448		NA								TSP Lung(15;0.13)			7	261					0	0	0	0
FREM1	158326	broad.mit.edu	37	9	14842546	14842546	+	Silent	SNP	G	G	A			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr9:14842546G>A	uc003zlm.2	-	9	2096	c.1506C>T	c.(1504-1506)GGC>GGT	p.G502G	FREM1_uc010mic.2_RNA	NM_144966	NP_659403	Q5H8C1	FREM1_HUMAN	FRAS1 related extracellular matrix 1 precursor	502	CSPG 2.				cell communication|multicellular organismal development	basement membrane|integral to membrane	metal ion binding|sugar binding			ovary(2)|breast(2)|pancreas(1)	5				GBM - Glioblastoma multiforme(50;3.53e-06)		TGCTGTGATGGCCATCAAATA	0.507		NA											10	278					0	0	0	0
KIF27	55582	broad.mit.edu	37	9	86495230	86495230	+	Silent	SNP	C	C	T			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr9:86495230C>T	uc004ana.2	-	11	2769	c.2625G>A	c.(2623-2625)CGG>CGA	p.R875R	KIF27_uc010mpw.2_Intron|KIF27_uc010mpx.2_Silent_p.R875R	NM_017576	NP_060046	Q86VH2	KIF27_HUMAN	kinesin family member 27	875	Potential.				cilium assembly|microtubule-based movement	cilium|cytoplasm|microtubule	ATP binding|microtubule motor activity			lung(4)|skin(1)	5						TTTGCTGGTCCCGCTTAATTA	0.353		NA											4	77					0	0	0	0
SECISBP2	79048	broad.mit.edu	37	9	91953402	91953402	+	Missense_Mutation	SNP	A	A	T			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr9:91953402A>T	uc004aqj.1	+	8	1199	c.1119A>T	c.(1117-1119)GAA>GAT	p.E373D	SECISBP2_uc010mqn.1_Missense_Mutation_p.E334D|SECISBP2_uc004aqi.1_Missense_Mutation_p.E261D|SECISBP2_uc011ltk.1_Missense_Mutation_p.E372D|SECISBP2_uc004aqk.1_Missense_Mutation_p.E300D|SECISBP2_uc010mqo.1_Missense_Mutation_p.E78D|SECISBP2_uc011ltl.1_Missense_Mutation_p.E305D	NM_024077	NP_076982	Q96T21	SEBP2_HUMAN	SECIS binding protein 2	373					translation	nucleus	mRNA 3'-UTR binding			ovary(2)|skin(1)	3						GTGACCTTGAACAAAATGAAG	0.333		NA											8	60					0	0	0	0
FANCC	2176	broad.mit.edu	37	9	97897696	97897696	+	Nonsense_Mutation	SNP	C	C	A			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr9:97897696C>A	uc004avh.2	-	8	1037	c.775G>T	c.(775-777)GAA>TAA	p.E259*	FANCC_uc004avi.3_Nonsense_Mutation_p.E259*	NM_000136	NP_000127	Q00597	FANCC_HUMAN	Fanconi anemia, complementation group C	259					protein complex assembly	cytosol|nucleoplasm	protein binding			kidney(1)	1		Acute lymphoblastic leukemia(62;0.138)				ATTAGCTTTTCAAAAAGATGC	0.428		NA	D|Mis|N|F|S			AML|leukemia		Genes_defective_in_diseases_associated_with_sensitivity_to_DNA_damaging_agents|Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				8	39					0.000442599	0.000475629	1	0
LRRC8A	56262	broad.mit.edu	37	9	131670584	131670584	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr9:131670584C>G	uc004bwl.3	+	3	1395	c.1141C>G	c.(1141-1143)CAA>GAA	p.Q381E	LRRC8A_uc010myp.2_Missense_Mutation_p.Q381E|LRRC8A_uc010myq.2_Missense_Mutation_p.Q381E	NM_019594	NP_062540	Q8IWT6	LRC8A_HUMAN	leucine rich repeat containing 8 family, member	381	LRR 1.				pre-B cell differentiation	integral to membrane					0						CCTCATTGACCAATACGACCC	0.562		NA											6	65					0	0	0	0
EHMT1	79813	broad.mit.edu	37	9	140637837	140637837	+	Missense_Mutation	SNP	G	G	T			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr9:140637837G>T	uc011mfc.1	+	5	875	c.838G>T	c.(838-840)GTT>TTT	p.V280F	EHMT1_uc004coa.2_Missense_Mutation_p.V280F|EHMT1_uc004cob.1_Missense_Mutation_p.V249F|EHMT1_uc010ncn.1_RNA	NM_024757	NP_079033	Q9H9B1	EHMT1_HUMAN	euchromatic histone-lysine N-methyltransferase 1	280					DNA methylation|embryo development|peptidyl-lysine dimethylation|peptidyl-lysine monomethylation	chromosome|nucleus	histone methyltransferase activity (H3-K27 specific)|histone methyltransferase activity (H3-K9 specific)|p53 binding|zinc ion binding			breast(2)|pancreas(1)	3	all_cancers(76;0.164)			OV - Ovarian serous cystadenocarcinoma(145;0.000183)|Epithelial(140;0.000728)		cttgccttttgttttAGCAGC	0.264		NA											7	34					5.18e-06	5.7e-06	1	0
RS1	6247	broad.mit.edu	37	X	18660205	18660205	+	Silent	SNP	G	G	A			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chrX:18660205G>A	uc004cyo.2	-	6	629	c.594C>T	c.(592-594)TTC>TTT	p.F198F	CDKL5_uc004cym.2_Intron|CDKL5_uc004cyn.2_Intron	NM_000330	NP_000321	O15537	XLRS1_HUMAN	X-linked juvenile retinoschisis protein	198	F5/8 type C.				cell adhesion|multicellular organismal development|response to stimulus|visual perception	extracellular space				ovary(2)	2	Hepatocellular(33;0.183)					TGAGGCGGATGAAGCGGGAGA	0.617		NA											11	48					0	0	0	0
MBTPS2	51360	broad.mit.edu	37	X	21896226	21896226	+	Missense_Mutation	SNP	C	C	A			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chrX:21896226C>A	uc004dae.2	+	8	1234	c.1037C>A	c.(1036-1038)TCC>TAC	p.S346Y	MBTPS2_uc010nfr.2_Intron	NM_015884	NP_056968	O43462	MBTP2_HUMAN	membrane-bound transcription factor peptidase,	346	Cys-rich.|Lumenal (Probable).				cholesterol metabolic process|proteolysis	Golgi membrane|integral to membrane	metal ion binding|metalloendopeptidase activity			ovary(1)	1						GTGTGCTTTTCCTACAGAAAT	0.343		NA											8	44					0.000157383	0.000170144	1	0
SUV39H1	6839	broad.mit.edu	37	X	48564702	48564702	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chrX:48564702G>A	uc004dkn.2	+	4	920	c.875G>A	c.(874-876)CGT>CAT	p.R292H	SUV39H1_uc011mmf.1_Missense_Mutation_p.R303H|SUV39H1_uc011mmg.1_RNA	NM_003173	NP_003164	O43463	SUV91_HUMAN	suppressor of variegation 3-9 homolog 1	292	Mediates interaction with MECOM (By similarity).|SET.				cell cycle|cell differentiation|chromatin silencing at rDNA|interspecies interaction between organisms|rRNA processing|transcription, DNA-dependent	chromatin silencing complex|chromosome, centromeric region|condensed nuclear chromosome|rDNA heterochromatin	chromatin binding|histone methyltransferase activity (H3-K9 specific)|protein N-terminus binding|zinc ion binding				0						ATCTACGACCGTCAGGGCGCC	0.582		NA											4	45					0	0	0	0
DGKK	139189	broad.mit.edu	37	X	50134545	50134545	+	Silent	SNP	G	G	A			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chrX:50134545G>A	uc010njr.1	-	11	1794	c.1734C>T	c.(1732-1734)ACC>ACT	p.T578T		NM_001013742	NP_001013764	Q5KSL6	DGKK_HUMAN	diacylglycerol kinase kappa	578	DAGKc.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|diacylglycerol metabolic process|intracellular signal transduction|platelet activation|response to oxidative stress	cytoplasm|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			ovary(1)|kidney(1)	2	Ovarian(276;0.236)					GATCATTGCCGGTTCCAAGTG	0.512		NA											7	45					0	0	0	0
ARR3	407	broad.mit.edu	37	X	69496004	69496004	+	Missense_Mutation	SNP	A	A	T			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chrX:69496004A>T	uc004dyb.2	+	6	286	c.218A>T	c.(217-219)AAA>ATA	p.K73I	ARR3_uc004dya.2_Missense_Mutation_p.K73I	NM_004312	NP_004303	P36575	ARRC_HUMAN	arrestin 3, retinal (X-arrestin)	73					signal transduction|visual perception	cytoplasm|soluble fraction				large_intestine(2)|ovary(2)	4						ACGTTCCGAAAAGATCTGTAT	0.542		NA											6	20					0	0	0	0
TCEAL8	90843	broad.mit.edu	37	X	102508843	102508843	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chrX:102508843C>T	uc004ejx.2	-	3	292	c.65G>A	c.(64-66)CGC>CAC	p.R22H	TCEAL8_uc004ejy.2_Missense_Mutation_p.R22H	NM_153333	NP_699164	Q8IYN2	TCAL8_HUMAN	transcription elongation factor A (SII)-like 8	22					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				ovary(1)	1						CTCCAAAGGGCGATCTTCCTC	0.443		NA											9	139					0	0	0	0
ATP1B4	23439	broad.mit.edu	37	X	119509241	119509241	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chrX:119509241C>G	uc004esr.2	+	5	661	c.577C>G	c.(577-579)CTT>GTT	p.L193V	ATP1B4_uc004esq.2_Missense_Mutation_p.L189V|ATP1B4_uc011mtx.1_Missense_Mutation_p.L158V|ATP1B4_uc011mty.1_Missense_Mutation_p.L150V	NM_001142447	NP_001135919	Q9UN42	AT1B4_HUMAN	ATPase, (Na+)/K+ transporting, beta 4	193	Perinuclear space (Potential).				ATP biosynthetic process|regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to plasma membrane|nuclear inner membrane	sodium:potassium-exchanging ATPase activity			ovary(1)|skin(1)	2						TAATGACAGTCTTCAAGAGGA	0.488		NA											10	80					0	0	0	0
GPR112	139378	broad.mit.edu	37	X	135431431	135431431	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chrX:135431431C>G	uc004ezu.1	+	6	5857	c.5566C>G	c.(5566-5568)CCC>GCC	p.P1856A	GPR112_uc010nsb.1_Missense_Mutation_p.P1651A|GPR112_uc010nsc.1_Missense_Mutation_p.P1623A	NM_153834	NP_722576	Q8IZF6	GP112_HUMAN	G-protein coupled receptor 112	1856	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(5)|large_intestine(2)|skin(2)|lung(1)|breast(1)|pancreas(1)	12	Acute lymphoblastic leukemia(192;0.000127)					CTCTCCTCCTCCCACATCCCA	0.448		NA											17	85					0	0	0	0
MCF2	4168	broad.mit.edu	37	X	138680607	138680607	+	Silent	SNP	G	G	C			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chrX:138680607G>C	uc004fau.2	-	17	2181	c.1887C>G	c.(1885-1887)CTC>CTG	p.L629L	MCF2_uc004fav.2_Silent_p.L645L|MCF2_uc011mwl.1_Silent_p.L606L|MCF2_uc010nsh.1_Silent_p.L629L|MCF2_uc011mwm.1_Silent_p.L590L|MCF2_uc011mwn.1_Silent_p.L774L|MCF2_uc004faw.2_Silent_p.L689L|MCF2_uc011mwo.1_Silent_p.L705L	NM_005369	NP_005360	P10911	MCF2_HUMAN	MCF.2 cell line derived transforming sequence	629	DH.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytoskeleton|cytosol|membrane|membrane fraction	protein binding|Rho guanyl-nucleotide exchange factor activity			lung(1)|pleura(1)	2	Acute lymphoblastic leukemia(192;0.000127)					GCACTGGTTTGAGTAAATAGG	0.299		NA											7	43					0	0	0	0
OR4K17	390436	broad.mit.edu	37	14	20586188	20586188	+	Frame_Shift_Del	DEL	T	T	-			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr14:20586188delT	uc001vwo.1	+	1	623	c.623delT	c.(622-624)ATTfs	p.I208fs		NM_001004715	NP_001004715	Q8NGC6	OR4KH_HUMAN	olfactory receptor, family 4, subfamily K,	180	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(3)	3	all_cancers(95;0.00108)		Epithelial(56;7.58e-07)|all cancers(55;3.77e-06)	GBM - Glioblastoma multiforme(265;0.0144)		GTAGACAGCATTTTTTGTGAC	0.448		NA											17	150	---	---	---	---	NA	NA	NA	NA
CASC5	57082	broad.mit.edu	37	15	40915007	40915010	+	Frame_Shift_Del	DEL	GGAA	GGAA	-			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr15:40915007_40915010delGGAA	uc010bbs.1	+	11	2784_2787	c.2623_2626delGGAA	c.(2623-2628)GGAAGGfs	p.G875fs	CASC5_uc010ucq.1_Frame_Shift_Del_p.G699fs|CASC5_uc001zme.2_Frame_Shift_Del_p.G849fs|CASC5_uc010bbt.1_Frame_Shift_Del_p.G849fs	NM_170589	NP_733468	Q8NG31	CASC5_HUMAN	cancer susceptibility candidate 5 isoform 1	875_876	2 X 104 AA approximate repeats.				acrosome assembly|attachment of spindle microtubules to kinetochore|cell division|CenH3-containing nucleosome assembly at centromere|mitotic prometaphase|spindle assembly checkpoint	acrosomal vesicle|condensed chromosome kinetochore|cytosol|nucleoplasm	protein binding			breast(3)|central_nervous_system(1)|skin(1)	5		all_cancers(109;2.03e-18)|all_epithelial(112;4.26e-15)|Lung NSC(122;1.12e-10)|all_lung(180;2.59e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.0946)		GBM - Glioblastoma multiforme(113;4.99e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0861)|COAD - Colon adenocarcinoma(120;0.211)		CAAAATTTGGGGAAGGAAAAGTGT	0.319		NA											7	39	---	---	---	---	NA	NA	NA	NA
ZNF638	27332	broad.mit.edu	37	2	71653593	71653596	+	Frame_Shift_Del	DEL	CCAT	CCAT	-			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr2:71653593_71653596delCCAT	uc002shx.2	+	24	4913_4916	c.4594_4597delCCAT	c.(4594-4599)CCATTAfs	p.P1532fs	ZNF638_uc002shy.2_Frame_Shift_Del_p.P1532fs|ZNF638_uc002shz.2_Frame_Shift_Del_p.P1532fs|ZNF638_uc002sia.2_Frame_Shift_Del_p.P1532fs|ZNF638_uc002sib.1_Frame_Shift_Del_p.S1123fs|ZNF638_uc010fed.2_Intron|ZNF638_uc002sic.2_Frame_Shift_Del_p.P629fs|ZNF638_uc002sid.2_5'UTR	NM_014497	NP_055312	Q14966	ZN638_HUMAN	zinc finger protein 638	1532_1533					RNA splicing	cytoplasm|nuclear speck	double-stranded DNA binding|nucleotide binding|RNA binding|zinc ion binding			pancreas(2)|ovary(1)|skin(1)	4						CCAACAGGAGCCATTATTTCCATT	0.353		NA											7	52	---	---	---	---	NA	NA	NA	NA
NICN1	84276	broad.mit.edu	37	3	49462293	49462293	+	Frame_Shift_Del	DEL	A	A	-			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr3:49462293delA	uc003cwz.1	-	6	700	c.615delT	c.(613-615)TATfs	p.Y205fs	AMT_uc011bcn.1_5'Flank|AMT_uc003cww.2_5'Flank|AMT_uc003cwx.2_5'Flank|AMT_uc011bco.1_5'Flank|AMT_uc003cwy.2_5'Flank|AMT_uc011bcp.1_5'Flank|AMT_uc011bcq.1_5'Flank|NICN1_uc003cxa.2_RNA|NICN1_uc011bcr.1_Frame_Shift_Del_p.Y167fs	NM_032316	NP_115692	Q9BSH3	NICN1_HUMAN	nicolin 1	205						microtubule|nucleus					0				BRCA - Breast invasive adenocarcinoma(193;4.52e-05)|Kidney(197;0.00217)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)		AGTTCAGGTCATAACAGCCAT	0.507		NA											17	15	---	---	---	---	NA	NA	NA	NA
KIAA0226	9711	broad.mit.edu	37	3	197423824	197423845	+	Splice_Site	DEL	CCATATTCCATGTACAGAGAGC	CCATATTCCATGTACAGAGAGC	-			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr3:197423824_197423845delCCATATTCCATGTACAGAGAGC	uc003fyc.2	-	8	1540	c.1357_splice	c.e8+1	p.E453_splice	KIAA0226_uc003fyd.3_Splice_Site_p.E408_splice|KIAA0226_uc003fye.1_Splice_Site_p.E160_splice|KIAA0226_uc003fyf.2_Splice_Site_p.E301_splice	NM_014687	NP_055502	Q92622	RUBIC_HUMAN	hypothetical protein LOC9711 isoform 2.						autophagy|endocytosis|negative regulation of autophagy|negative regulation of endocytosis	early endosome|late endosome|lysosome	protein binding				0	all_cancers(143;8.26e-10)|Ovarian(172;0.0418)|Breast(254;0.0976)		Epithelial(36;2.19e-23)|all cancers(36;1.39e-21)|OV - Ovarian serous cystadenocarcinoma(49;1.21e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(93;0.0446)		CTAGTACTCACCATATTCCATGTACAGAGAGCTGGGTGTGCT	0.486		NA											7	27	---	---	---	---	NA	NA	NA	NA