Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	isArtifactMode	oxoGCut
UBE4B	10277	broad.mit.edu	37	1	10239993	10239993	+	Silent	SNP	G	G	A			TCGA-CV-7413-01A-11D-2078-08	TCGA-CV-7413-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be482a19-0de0-4e60-a831-9ebe8545a6f3	741ec714-2c58-4d0c-a373-be69346da938	g.chr1:10239993G>A	uc001aqs.3	+	28	4601	c.3888G>A	c.(3886-3888)GAG>GAA	p.E1296E	UBE4B_uc001aqr.3_Silent_p.E1167E|UBE4B_uc010oai.1_RNA|UBE4B_uc010oaj.1_Silent_p.E751E|UBE4B_uc001aqu.2_Silent_p.E177E	NM_001105562	NP_001099032	O95155	UBE4B_HUMAN	ubiquitination factor E4B isoform 1	1296					apoptosis|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to UV	cytoplasm|ubiquitin ligase complex	enzyme binding			ovary(2)|skin(2)	4		all_lung(284;1.13e-05)|Lung NSC(185;1.74e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0268)|Colorectal(212;1.42e-07)|COAD - Colon adenocarcinoma(227;2.77e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000435)|Kidney(185;0.000482)|KIRC - Kidney renal clear cell carcinoma(229;0.00164)|STAD - Stomach adenocarcinoma(132;0.0117)|READ - Rectum adenocarcinoma(331;0.046)		GGATGAGAGAGAAACAGAACA	0.552		NA											8	40					0	0	0	0
PTCHD2	57540	broad.mit.edu	37	1	11561896	11561896	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7413-01A-11D-2078-08	TCGA-CV-7413-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be482a19-0de0-4e60-a831-9ebe8545a6f3	741ec714-2c58-4d0c-a373-be69346da938	g.chr1:11561896G>A	uc001ash.3	+	2	985	c.847G>A	c.(847-849)GGC>AGC	p.G283S	PTCHD2_uc001asi.1_Missense_Mutation_p.G283S	NM_020780	NP_065831	Q9P2K9	PTHD2_HUMAN	patched domain containing 2	283	Extracellular (Potential).				cholesterol homeostasis|regulation of lipid transport|smoothened signaling pathway	endoplasmic reticulum|integral to membrane|nuclear membrane	hedgehog receptor activity			skin(3)|ovary(2)|pancreas(1)|breast(1)	7	Ovarian(185;0.249)	Lung NSC(185;4.16e-05)|all_lung(284;4.76e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.13e-07)|COAD - Colon adenocarcinoma(227;4.83e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000325)|Kidney(185;0.000877)|KIRC - Kidney renal clear cell carcinoma(229;0.00273)|STAD - Stomach adenocarcinoma(313;0.00766)|READ - Rectum adenocarcinoma(331;0.0549)		CCTGGCGCGCGGCGACGCGGA	0.647		NA											5	20					0	0	0	0
ARHGEF10L	55160	broad.mit.edu	37	1	18023742	18023742	+	Missense_Mutation	SNP	G	G	T			TCGA-CV-7413-01A-11D-2078-08	TCGA-CV-7413-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be482a19-0de0-4e60-a831-9ebe8545a6f3	741ec714-2c58-4d0c-a373-be69346da938	g.chr1:18023742G>T	uc001ban.2	+	29	3866	c.3707G>T	c.(3706-3708)TGC>TTC	p.C1236F	ARHGEF10L_uc001bao.2_Missense_Mutation_p.C1197F|ARHGEF10L_uc001bap.2_Missense_Mutation_p.C1192F|ARHGEF10L_uc001baq.2_Missense_Mutation_p.C997F|ARHGEF10L_uc010ocs.1_Missense_Mutation_p.C1009F|ARHGEF10L_uc001bar.2_Missense_Mutation_p.C939F|ARHGEF10L_uc009vpf.2_RNA|ARHGEF10L_uc001bas.2_Missense_Mutation_p.C260F	NM_018125	NP_060595	Q9HCE6	ARGAL_HUMAN	Rho guanine nucleotide exchange factor (GEF)	1236					regulation of Rho protein signal transduction	cytoplasm	Rho guanyl-nucleotide exchange factor activity			large_intestine(1)|ovary(1)|pancreas(1)	3		Colorectal(325;3.46e-05)|Breast(348;0.000162)|all_lung(284;0.000337)|Lung NSC(340;0.000419)|Renal(390;0.000518)|Ovarian(437;0.00409)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00598)|COAD - Colon adenocarcinoma(227;1.62e-05)|BRCA - Breast invasive adenocarcinoma(304;1.68e-05)|Kidney(64;0.000269)|KIRC - Kidney renal clear cell carcinoma(64;0.00361)|STAD - Stomach adenocarcinoma(196;0.00656)|READ - Rectum adenocarcinoma(331;0.0718)|Lung(427;0.204)		AAGGAGATTTGCTCTGTGGCC	0.687		NA											13	31					7.04e-09	7.9e-09	1	0
KPNA6	23633	broad.mit.edu	37	1	32628883	32628883	+	Missense_Mutation	SNP	A	A	G			TCGA-CV-7413-01A-11D-2078-08	TCGA-CV-7413-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be482a19-0de0-4e60-a831-9ebe8545a6f3	741ec714-2c58-4d0c-a373-be69346da938	g.chr1:32628883A>G	uc001bug.2	+	10	1047	c.959A>G	c.(958-960)AAC>AGC	p.N320S	KPNA6_uc001buh.2_Missense_Mutation_p.N95S|KPNA6_uc010ogx.1_Missense_Mutation_p.N317S|KPNA6_uc010ogy.1_Missense_Mutation_p.N325S|KPNA6_uc009vtz.2_Missense_Mutation_p.N215S	NM_012316	NP_036448	O60684	IMA7_HUMAN	karyopherin alpha 6	320	NLS binding site (minor) (By similarity).|ARM 6.				NLS-bearing substrate import into nucleus	cytoplasm|nuclear pore	protein binding				0		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Ovarian(437;0.101)|Breast(348;0.174)				GCCGTGGGTAACATCGTCACT	0.542		NA											6	18					0	0	0	0
MAEL	84944	broad.mit.edu	37	1	166985521	166985521	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7413-01A-11D-2078-08	TCGA-CV-7413-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be482a19-0de0-4e60-a831-9ebe8545a6f3	741ec714-2c58-4d0c-a373-be69346da938	g.chr1:166985521C>T	uc001gdy.1	+	9	979	c.908C>T	c.(907-909)GCG>GTG	p.A303V	MAEL_uc001gdz.1_Missense_Mutation_p.A272V|MAEL_uc009wvf.1_RNA	NM_032858	NP_116247	Q96JY0	MAEL_HUMAN	maelstrom homolog	303					cell differentiation|DNA methylation involved in gamete generation|gene silencing by RNA|multicellular organismal development|piRNA metabolic process|spermatogenesis	piP-body	DNA binding			skin(1)	1						AAGAAGATTGCGTAAGTTGGG	0.368		NA											11	52					0	0	0	0
DUSP27	92235	broad.mit.edu	37	1	167095880	167095880	+	Silent	SNP	G	G	A			TCGA-CV-7413-01A-11D-2078-08	TCGA-CV-7413-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be482a19-0de0-4e60-a831-9ebe8545a6f3	741ec714-2c58-4d0c-a373-be69346da938	g.chr1:167095880G>A	uc001geb.1	+	5	1512	c.1512G>A	c.(1510-1512)GCG>GCA	p.A504A		NM_001080426	NP_001073895	Q5VZP5	DUS27_HUMAN	dual specificity phosphatase 27	504					protein dephosphorylation		protein tyrosine/serine/threonine phosphatase activity			ovary(3)	3						GAGAGGAGGCGGCAGACAGGA	0.602		NA											11	29					0	0	0	0
RASAL2	9462	broad.mit.edu	37	1	178411963	178411963	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7413-01A-11D-2078-08	TCGA-CV-7413-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be482a19-0de0-4e60-a831-9ebe8545a6f3	741ec714-2c58-4d0c-a373-be69346da938	g.chr1:178411963G>A	uc001glr.2	+	6	762	c.637G>A	c.(637-639)GGC>AGC	p.G213S	RASAL2_uc001glq.2_Missense_Mutation_p.G361S	NM_004841	NP_004832	Q9UJF2	NGAP_HUMAN	RAS protein activator like 2 isoform 1	213	C2.				negative regulation of Ras protein signal transduction|signal transduction	cytoplasm|intrinsic to internal side of plasma membrane	Ras GTPase activator activity			ovary(2)|breast(2)|large_intestine(1)	5						TATTTTCTGGGGCGAACATTT	0.388		NA											16	84					0	0	0	0
CYB5R1	51706	broad.mit.edu	37	1	202935050	202935050	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7413-01A-11D-2078-08	TCGA-CV-7413-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be482a19-0de0-4e60-a831-9ebe8545a6f3	741ec714-2c58-4d0c-a373-be69346da938	g.chr1:202935050C>T	uc001gyt.2	-	4	381	c.310G>A	c.(310-312)GAT>AAT	p.D104N	CYB5R1_uc010pqe.1_RNA	NM_016243	NP_057327	Q9UHQ9	NB5R1_HUMAN	cytochrome b5 reductase 1	104	FAD-binding FR-type.				sterol biosynthetic process	integral to membrane	cytochrome-b5 reductase activity			ovary(1)	1			BRCA - Breast invasive adenocarcinoma(75;0.141)			TGATCCTCATCACTGGTGACA	0.507		NA											6	26					0	0	0	0
GALNT2	2590	broad.mit.edu	37	1	230381875	230381875	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7413-01A-11D-2078-08	TCGA-CV-7413-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be482a19-0de0-4e60-a831-9ebe8545a6f3	741ec714-2c58-4d0c-a373-be69346da938	g.chr1:230381875G>A	uc010pwa.1	+	8	868	c.796G>A	c.(796-798)GCA>ACA	p.A266T	GALNT2_uc010pvy.1_Missense_Mutation_p.A228T|GALNT2_uc010pvz.1_RNA	NM_004481	NP_004472	Q10471	GALT2_HUMAN	polypeptide N-acetylgalactosaminyltransferase 2	266	Lumenal (Potential).				immunoglobulin biosynthetic process|protein O-linked glycosylation via serine|protein O-linked glycosylation via threonine	extracellular region|Golgi cisterna membrane|integral to Golgi membrane|perinuclear region of cytoplasm	manganese ion binding|polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			ovary(2)	2	Breast(184;0.193)|Ovarian(103;0.249)	all_cancers(173;0.156)|Prostate(94;0.179)				GTATGTGGGGGCATCTGCTGA	0.493		NA											9	45					0	0	0	0
CELF2	10659	broad.mit.edu	37	10	11370983	11370983	+	Silent	SNP	G	G	A			TCGA-CV-7413-01A-11D-2078-08	TCGA-CV-7413-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be482a19-0de0-4e60-a831-9ebe8545a6f3	741ec714-2c58-4d0c-a373-be69346da938	g.chr10:11370983G>A	uc001iki.3	+	13	1586	c.1494G>A	c.(1492-1494)CTG>CTA	p.L498L	CELF2_uc010qbj.1_Silent_p.L504L|CELF2_uc001ikk.2_Silent_p.L523L|CELF2_uc001ikl.3_Silent_p.L511L|CELF2_uc010qbl.1_Silent_p.L474L|CELF2_uc010qbm.1_Silent_p.L270L|CELF2_uc001iko.3_Silent_p.L478L|CELF2_uc001ikp.3_Silent_p.L480L|CELF2_uc010qbn.1_Silent_p.L486L|CELF2_uc010qbo.1_Silent_p.L393L|CELF2_uc010qbp.1_Silent_p.L270L	NM_001025077	NP_001020248	O95319	CELF2_HUMAN	CUG triplet repeat, RNA binding protein 2	498	RRM 3.|Necessary for RNA-binding, TNNT2 exon 5 and NMDA R1 exon 21 inclusion.				mRNA processing|regulation of heart contraction	cytoplasm|nucleus	nucleotide binding|protein binding|RNA binding				0						AGGTGCAGCTGAAGCGTTCCA	0.488		NA											12	59					0	0	0	0
SEC61A2	55176	broad.mit.edu	37	10	12191922	12191922	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7413-01A-11D-2078-08	TCGA-CV-7413-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be482a19-0de0-4e60-a831-9ebe8545a6f3	741ec714-2c58-4d0c-a373-be69346da938	g.chr10:12191922G>A	uc001ile.2	+	6	571	c.424G>A	c.(424-426)GAA>AAA	p.E142K	SEC61A2_uc010qbq.1_Missense_Mutation_p.E120K|SEC61A2_uc001ilf.3_RNA|SEC61A2_uc001ilh.3_RNA|SEC61A2_uc001ilg.3_Missense_Mutation_p.E142K	NM_018144	NP_060614	Q9H9S3	S61A2_HUMAN	Sec61 alpha form 2 isoform a	142	Lumenal (Potential).					endoplasmic reticulum membrane|integral to membrane	P-P-bond-hydrolysis-driven protein transmembrane transporter activity			ovary(1)	1		Renal(717;0.228)				GGACCCTGCAGAAATGGGTGC	0.428		NA											15	60					0	0	0	0
HPS6	79803	broad.mit.edu	37	10	103826339	103826339	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7413-01A-11D-2078-08	TCGA-CV-7413-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be482a19-0de0-4e60-a831-9ebe8545a6f3	741ec714-2c58-4d0c-a373-be69346da938	g.chr10:103826339G>A	uc001kuj.2	+	1	1193	c.1108G>A	c.(1108-1110)GAG>AAG	p.E370K		NM_024747	NP_079023	Q86YV9	HPS6_HUMAN	Hermansky-Pudlak syndrome-6	370						cytosol|early endosome membrane|endoplasmic reticulum|microsome					0		Colorectal(252;0.122)		Epithelial(162;5.93e-08)|all cancers(201;1.03e-06)		GGAAGAGCTGGAGACCCGAGG	0.582		NA							Hermansky-Pudlak_syndrome				12	47					0	0	0	0
SORCS3	22986	broad.mit.edu	37	10	106899230	106899230	+	Missense_Mutation	SNP	T	T	C			TCGA-CV-7413-01A-11D-2078-08	TCGA-CV-7413-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be482a19-0de0-4e60-a831-9ebe8545a6f3	741ec714-2c58-4d0c-a373-be69346da938	g.chr10:106899230T>C	uc001kyi.1	+	8	1515	c.1288T>C	c.(1288-1290)TAC>CAC	p.Y430H		NM_014978	NP_055793	Q9UPU3	SORC3_HUMAN	VPS10 domain receptor protein SORCS 3 precursor	430	Lumenal (Potential).					integral to membrane	neuropeptide receptor activity			ovary(6)|skin(3)|central_nervous_system(1)	10		Colorectal(252;0.134)|Breast(234;0.142)|Lung NSC(174;0.191)		Epithelial(162;1.58e-07)|all cancers(201;1.02e-05)|BRCA - Breast invasive adenocarcinoma(275;0.0628)		GCTGCCTAAGTACTCGTTGCC	0.512		NA											14	53					0	0	0	0
SIRT3	23410	broad.mit.edu	37	11	219014	219014	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7413-01A-11D-2078-08	TCGA-CV-7413-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be482a19-0de0-4e60-a831-9ebe8545a6f3	741ec714-2c58-4d0c-a373-be69346da938	g.chr11:219014C>T	uc001lok.3	-	6	1031	c.997G>A	c.(997-999)GCC>ACC	p.A333T	SIRT3_uc001loj.3_Missense_Mutation_p.A191T|SIRT3_uc010qvm.1_Missense_Mutation_p.A269T|SIRT3_uc010qvn.1_Missense_Mutation_p.A252T|SIRT3_uc010qvo.1_Missense_Mutation_p.A333T|SIRT3_uc010qvp.1_Missense_Mutation_p.A279T|SIRT3_uc010qvq.1_Missense_Mutation_p.A191T	NM_012239	NP_036371	Q9NTG7	SIRT3_HUMAN	sirtuin 3 isoform a	333	Deacetylase sirtuin-type.				chromatin silencing|protein ADP-ribosylation|protein deacetylation	mitochondrial matrix	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides|NAD+ ADP-ribosyltransferase activity|NAD+ binding|protein binding|zinc ion binding			urinary_tract(1)	1		all_cancers(49;1.58e-09)|all_epithelial(84;2.71e-06)|Breast(177;0.000162)|Ovarian(85;0.000626)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.0538)|all_lung(207;0.0713)		all cancers(45;3.66e-27)|Epithelial(43;2.02e-26)|OV - Ovarian serous cystadenocarcinoma(40;2.9e-21)|BRCA - Breast invasive adenocarcinoma(625;3.88e-05)|Lung(200;0.111)|LUSC - Lung squamous cell carcinoma(625;0.129)		CTCCGCACGGCCTCGGTCAAG	0.612		NA											8	13					0	0	0	0
ACSM4	341392	broad.mit.edu	37	12	7469847	7469847	+	Silent	SNP	C	C	T			TCGA-CV-7413-01A-11D-2078-08	TCGA-CV-7413-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be482a19-0de0-4e60-a831-9ebe8545a6f3	741ec714-2c58-4d0c-a373-be69346da938	g.chr12:7469847C>T	uc001qsx.1	+	4	735	c.735C>T	c.(733-735)AGC>AGT	p.S245S		NM_001080454	NP_001073923	P0C7M7	ACSM4_HUMAN	acyl-CoA synthetase medium-chain family member 4	245					fatty acid metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|metal ion binding				0						CTCAGAGCAGCCTCGGCATTG	0.393		NA											4	4					0	0	0	0
CLEC9A	283420	broad.mit.edu	37	12	10213747	10213747	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7413-01A-11D-2078-08	TCGA-CV-7413-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be482a19-0de0-4e60-a831-9ebe8545a6f3	741ec714-2c58-4d0c-a373-be69346da938	g.chr12:10213747C>T	uc001qxa.2	+	6	807	c.194C>T	c.(193-195)GCG>GTG	p.A65V		NM_207345	NP_997228	Q6UXN8	CLC9A_HUMAN	C-type lectin domain family 9, member A	65	Extracellular (Potential).				positive regulation of cytokine secretion|receptor-mediated endocytosis	cell surface|integral to membrane	receptor activity|sugar binding			ovary(1)	1						TCCACCATTGCGATGCAGCAG	0.403		NA											5	16					0	0	0	0
KRT79	338785	broad.mit.edu	37	12	53217762	53217762	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7413-01A-11D-2078-08	TCGA-CV-7413-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be482a19-0de0-4e60-a831-9ebe8545a6f3	741ec714-2c58-4d0c-a373-be69346da938	g.chr12:53217762C>T	uc001sbb.2	-	6	1088	c.1055G>A	c.(1054-1056)GGG>GAG	p.G352E	KRT79_uc001sba.2_Missense_Mutation_p.G123E	NM_175834	NP_787028	Q5XKE5	K2C79_HUMAN	keratin 6L	352	Rod.|Coil 2.					keratin filament	structural molecule activity			ovary(2)|skin(2)	4						CAGGTTGTCCCCATGCTTCCC	0.612		NA											10	33					0	0	0	0
OR6C4	341418	broad.mit.edu	37	12	55945682	55945682	+	Silent	SNP	G	G	T			TCGA-CV-7413-01A-11D-2078-08	TCGA-CV-7413-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be482a19-0de0-4e60-a831-9ebe8545a6f3	741ec714-2c58-4d0c-a373-be69346da938	g.chr12:55945682G>T	uc010spp.1	+	1	672	c.672G>T	c.(670-672)CTG>CTT	p.L224L		NM_001005494	NP_001005494	Q8NGE1	OR6C4_HUMAN	olfactory receptor, family 6, subfamily C,	224	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						GGACTATTCTGAGGATCCCTT	0.468		NA											13	64					4.37e-10	4.93e-10	1	0
OAS2	4939	broad.mit.edu	37	12	113444282	113444282	+	Silent	SNP	A	A	G			TCGA-CV-7413-01A-11D-2078-08	TCGA-CV-7413-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be482a19-0de0-4e60-a831-9ebe8545a6f3	741ec714-2c58-4d0c-a373-be69346da938	g.chr12:113444282A>G	uc001tuj.2	+	8	1673	c.1533A>G	c.(1531-1533)AAA>AAG	p.K511K	OAS2_uc001tui.1_Silent_p.K511K	NM_016817	NP_058197	P29728	OAS2_HUMAN	2'-5'-oligoadenylate synthetase 2 isoform 1	511	OAS domain 2.				interferon-gamma-mediated signaling pathway|nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|type I interferon-mediated signaling pathway	endoplasmic reticulum|membrane|microsome|mitochondrion|nucleus	ATP binding|nucleotidyltransferase activity|RNA binding			ovary(1)	1						ATCTGTATAAATCCTCGGACC	0.512		NA											26	69					0	0	0	0
RIMBP2	23504	broad.mit.edu	37	12	130892282	130892282	+	Missense_Mutation	SNP	C	C	T	rs142858015	byFrequency	TCGA-CV-7413-01A-11D-2078-08	TCGA-CV-7413-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be482a19-0de0-4e60-a831-9ebe8545a6f3	741ec714-2c58-4d0c-a373-be69346da938	g.chr12:130892282C>T	uc001uil.2	-	16	3078	c.2914G>A	c.(2914-2916)GTC>ATC	p.V972I		NM_015347	NP_056162	O15034	RIMB2_HUMAN	RIM-binding protein 2	972	SH3 3.					cell junction|synapse				upper_aerodigestive_tract(3)|ovary(3)|large_intestine(2)|central_nervous_system(2)|pancreas(1)	11	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.213)		OV - Ovarian serous cystadenocarcinoma(86;4.29e-06)|all cancers(50;4.56e-05)|Epithelial(86;5.41e-05)		TCGACATCGACGTTGGGCGAG	0.567		NA											52	186					0	0	0	0
C14orf174	161394	broad.mit.edu	37	14	77844099	77844099	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7413-01A-11D-2078-08	TCGA-CV-7413-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be482a19-0de0-4e60-a831-9ebe8545a6f3	741ec714-2c58-4d0c-a373-be69346da938	g.chr14:77844099G>A	uc001xtq.1	+	1	338	c.338G>A	c.(337-339)AGA>AAA	p.R113K	TMED8_uc010ast.1_5'Flank|TMED8_uc001xto.1_5'Flank	NM_001010860	NP_001010860	Q9P1V8	SAM15_HUMAN	hypothetical protein LOC161394	113											0			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0278)		GAAACATCCAGAGAGATGGGA	0.493		NA											19	125					0	0	0	0
ACSBG1	23205	broad.mit.edu	37	15	78526821	78526821	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7413-01A-11D-2078-08	TCGA-CV-7413-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be482a19-0de0-4e60-a831-9ebe8545a6f3	741ec714-2c58-4d0c-a373-be69346da938	g.chr15:78526821C>T	uc002bdh.2	-	1	79	c.23G>A	c.(22-24)GGA>GAA	p.G8E	ACSBG1_uc010umw.1_Missense_Mutation_p.G8E|ACSBG1_uc010umx.1_5'UTR|ACSBG1_uc010umy.1_5'UTR	NM_015162	NP_055977	Q96GR2	ACBG1_HUMAN	lipidosin	8					long-chain fatty acid metabolic process|myelination|very long-chain fatty acid metabolic process	cytoplasmic membrane-bounded vesicle|endoplasmic reticulum|microsome	ATP binding|long-chain fatty acid-CoA ligase activity|very long-chain fatty acid-CoA ligase activity			ovary(1)	1						GCAGCCGTATCCAGCTCCAGA	0.597		NA											38	195					0	0	0	0
AGBL1	123624	broad.mit.edu	37	15	87531246	87531246	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7413-01A-11D-2078-08	TCGA-CV-7413-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be482a19-0de0-4e60-a831-9ebe8545a6f3	741ec714-2c58-4d0c-a373-be69346da938	g.chr15:87531246C>G	uc002blz.1	+	23	3192	c.3112C>G	c.(3112-3114)CAT>GAT	p.H1038D		NM_152336	NP_689549	Q96MI9	CBPC4_HUMAN	ATP/GTP binding protein-like 1	1038					C-terminal protein deglutamylation|protein side chain deglutamylation|proteolysis	cytosol	metallocarboxypeptidase activity|tubulin binding|zinc ion binding				0						cctgccaaagcatatttggtt	0		NA											43	104					0	0	0	0
ADAMTS17	170691	broad.mit.edu	37	15	100657103	100657103	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7413-01A-11D-2078-08	TCGA-CV-7413-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be482a19-0de0-4e60-a831-9ebe8545a6f3	741ec714-2c58-4d0c-a373-be69346da938	g.chr15:100657103C>T	uc002bvv.1	-	13	1916	c.1837G>A	c.(1837-1839)GAC>AAC	p.D613N	ADAMTS17_uc002bvx.1_Missense_Mutation_p.D370N	NM_139057	NP_620688	Q8TE56	ATS17_HUMAN	ADAM metallopeptidase with thrombospondin type 1	613	Cys-rich.				proteolysis	intracellular|proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(2)|central_nervous_system(1)	3	Lung NSC(78;0.00299)|all_lung(78;0.00457)|Melanoma(26;0.00571)		OV - Ovarian serous cystadenocarcinoma(32;0.0013)|LUSC - Lung squamous cell carcinoma(107;0.132)|Lung(145;0.161)	COAD - Colon adenocarcinoma(1;0.111)|all cancers(203;0.219)		CTCAGCCGGTCGTGTGCCTGG	0.627		NA											22	38					0	0	0	0
PDXDC1	23042	broad.mit.edu	37	16	15128328	15128328	+	Silent	SNP	G	G	A			TCGA-CV-7413-01A-11D-2078-08	TCGA-CV-7413-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be482a19-0de0-4e60-a831-9ebe8545a6f3	741ec714-2c58-4d0c-a373-be69346da938	g.chr16:15128328G>A	uc002dda.3	+	21	2144	c.1920G>A	c.(1918-1920)CAG>CAA	p.Q640Q	PDXDC1_uc010uzl.1_Silent_p.Q625Q|PDXDC1_uc010uzm.1_Silent_p.Q549Q|PDXDC1_uc002ddb.3_Silent_p.Q613Q|PDXDC1_uc010uzn.1_Silent_p.Q612Q|PDXDC1_uc002ddc.2_Intron	NM_015027	NP_055842	Q6P996	PDXD1_HUMAN	pyridoxal-dependent decarboxylase domain	640					carboxylic acid metabolic process		carboxy-lyase activity|protein binding|pyridoxal phosphate binding			skin(1)	1					Pyridoxal Phosphate(DB00114)	TGTTGCGGCAGATCCCTGTAG	0.602		NA											30	105					0	0	0	0
TAOK2	9344	broad.mit.edu	37	16	29994159	29994159	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7413-01A-11D-2078-08	TCGA-CV-7413-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be482a19-0de0-4e60-a831-9ebe8545a6f3	741ec714-2c58-4d0c-a373-be69346da938	g.chr16:29994159G>A	uc002dva.1	+	11	1719	c.936G>A	c.(934-936)ATG>ATA	p.M312I	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|TAOK2_uc002dvb.1_Missense_Mutation_p.M312I|TAOK2_uc002dvc.1_Missense_Mutation_p.M312I|TAOK2_uc010bzm.1_Missense_Mutation_p.M312I|TAOK2_uc002dvd.1_Missense_Mutation_p.M139I	NM_016151	NP_057235	Q9UL54	TAOK2_HUMAN	TAO kinase 2 isoform 2	312					actin cytoskeleton organization|activation of MAPKK activity|apoptosis|cell migration|focal adhesion assembly|positive regulation of JNK cascade|protein targeting to membrane|regulation of cell growth|regulation of cell shape|response to stress	cytoplasmic vesicle membrane|cytoskeleton|dendrite|integral to membrane|nucleolus	ATP binding|protein serine/threonine kinase activity			ovary(1)	1						ACCGCAAGATGAAGAAGATCC	0.607		NA											20	61					0	0	0	0
THAP11	57215	broad.mit.edu	37	16	67876720	67876720	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7413-01A-11D-2078-08	TCGA-CV-7413-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be482a19-0de0-4e60-a831-9ebe8545a6f3	741ec714-2c58-4d0c-a373-be69346da938	g.chr16:67876720G>C	uc002euo.2	+	1	508	c.263G>C	c.(262-264)CGC>CCC	p.R88P	CENPT_uc002eun.3_Intron	NM_020457	NP_065190	Q96EK4	THA11_HUMAN	THAP domain containing 11	88					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|identical protein binding|metal ion binding				0		Acute lymphoblastic leukemia(13;0.000299)|all_hematologic(13;0.0184)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.00412)|Epithelial(162;0.018)|all cancers(182;0.118)		GTCAATGAGCGCAAAGTAGCG	0.408		NA											7	17					0	0	0	0
TP53	7157	broad.mit.edu	37	17	7579374	7579374	+	Missense_Mutation	SNP	C	C	A			TCGA-CV-7413-01A-11D-2078-08	TCGA-CV-7413-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be482a19-0de0-4e60-a831-9ebe8545a6f3	741ec714-2c58-4d0c-a373-be69346da938	g.chr17:7579374C>A	uc002gim.2	-	4	507	c.313G>T	c.(313-315)GGC>TGC	p.G105C	TP53_uc002gig.1_Missense_Mutation_p.G105C|TP53_uc002gih.2_Missense_Mutation_p.G105C|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_5'Flank|TP53_uc010cng.1_5'Flank|TP53_uc002gii.1_5'Flank|TP53_uc010cnh.1_Missense_Mutation_p.G105C|TP53_uc010cni.1_Missense_Mutation_p.G105C|TP53_uc002gij.2_Missense_Mutation_p.G105C|TP53_uc010cnj.1_5'Flank|TP53_uc002gin.2_Intron|TP53_uc002gio.2_Intron|TP53_uc010vug.1_Missense_Mutation_p.G66C|TP53_uc010cnk.1_Missense_Mutation_p.G120C	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	105	Interaction with HIPK1 (By similarity).||Interaction with WWOX.		G -> D (in sporadic cancers; somatic mutation).|G -> S (in a sporadic cancer; somatic mutation).|G -> V (in sporadic cancers; somatic mutation).|G -> C (in LFS; germline mutation and in sporadic cancers; somatic mutation).|G -> R (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.0?(7)|p.G105C(5)|p.G105fs*18(3)|p.G59fs*23(3)|p.G105R(2)|p.V73fs*9(1)|p.G105_T125del21(1)|p.G105A(1)|p.G105S(1)|p.G105V(1)|p.W91fs*13(1)|p.Y103_G112>C(1)|p.P13fs*18(1)|p.S33fs*23(1)|p.G105G(1)|p.G105D(1)|p.Y103_L111>L(1)|p.Y103fs*15(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CCGTAGCTGCCCTGGTAGGTT	0.627		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			31	38					3.99e-17	4.57e-17	1	0
RAI1	10743	broad.mit.edu	37	17	17696924	17696924	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7413-01A-11D-2078-08	TCGA-CV-7413-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be482a19-0de0-4e60-a831-9ebe8545a6f3	741ec714-2c58-4d0c-a373-be69346da938	g.chr17:17696924C>T	uc002grm.2	+	3	1131	c.662C>T	c.(661-663)ACC>ATC	p.T221I	RAI1_uc002grn.1_Missense_Mutation_p.T221I	NM_030665	NP_109590	Q7Z5J4	RAI1_HUMAN	retinoic acid induced 1	221	Gln-rich.					cytoplasm|nucleus	zinc ion binding			central_nervous_system(1)|skin(1)	2				READ - Rectum adenocarcinoma(1115;0.0276)		ACCTCCTCCACCTACTCCTCC	0.627		NA											36	68					0	0	0	0
ARHGAP27	201176	broad.mit.edu	37	17	43472974	43472974	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7413-01A-11D-2078-08	TCGA-CV-7413-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be482a19-0de0-4e60-a831-9ebe8545a6f3	741ec714-2c58-4d0c-a373-be69346da938	g.chr17:43472974G>A	uc002iix.2	-	17	1944	c.1495C>T	c.(1495-1497)CGC>TGC	p.R499C	ARHGAP27_uc010dak.2_Missense_Mutation_p.R472C	NM_199282	NP_954976	Q6ZUM4	RHG27_HUMAN	Rho GTPase activating protein 27 isoform a	840	Rho-GAP.				positive regulation of Cdc42 GTPase activity|receptor-mediated endocytosis|signal transduction	cytoplasm|membrane	Rac GTPase activator activity|SH3 domain binding				0	Renal(3;0.0405)					ACCGACATGCGGTTCTGCTCG	0.667		NA											3	9					0	0	0	0
ANKRD30B	374860	broad.mit.edu	37	18	14782606	14782606	+	Missense_Mutation	SNP	A	A	C			TCGA-CV-7413-01A-11D-2078-08	TCGA-CV-7413-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be482a19-0de0-4e60-a831-9ebe8545a6f3	741ec714-2c58-4d0c-a373-be69346da938	g.chr18:14782606A>C	uc010dlo.2	+	12	1743	c.1563A>C	c.(1561-1563)GAA>GAC	p.E521D	ANKRD30B_uc010xak.1_RNA	NM_001145029	NP_001138501	Q9BXX2	AN30B_HUMAN	ankyrin repeat domain 30B	521										ovary(1)|skin(1)	2						TAAATAGAGAAGTAGAAGGTA	0.313		NA											6	13					0	0	0	0
LAMA3	3909	broad.mit.edu	37	18	21444832	21444832	+	Silent	SNP	G	G	A			TCGA-CV-7413-01A-11D-2078-08	TCGA-CV-7413-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be482a19-0de0-4e60-a831-9ebe8545a6f3	741ec714-2c58-4d0c-a373-be69346da938	g.chr18:21444832G>A	uc002kuq.2	+	36	4754	c.4668G>A	c.(4666-4668)CCG>CCA	p.P1556P	LAMA3_uc002kur.2_Silent_p.P1556P	NM_198129	NP_937762	Q16787	LAMA3_HUMAN	laminin alpha 3 subunit isoform 1	1556	Laminin IV type A.				cell adhesion|epidermis development|hemidesmosome assembly|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|skin(2)|central_nervous_system(1)	11	all_cancers(21;7.81e-05)|all_epithelial(16;4.45e-07)|Lung NSC(20;0.00156)|all_lung(20;0.00508)|Colorectal(14;0.0202)|Ovarian(20;0.17)				Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	AAAAGAAGCCGGATGTACAGC	0.448		NA											3	51					0	0	0	0
DSEL	92126	broad.mit.edu	37	18	65179933	65179933	+	Missense_Mutation	SNP	T	T	A			TCGA-CV-7413-01A-11D-2078-08	TCGA-CV-7413-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be482a19-0de0-4e60-a831-9ebe8545a6f3	741ec714-2c58-4d0c-a373-be69346da938	g.chr18:65179933T>A	uc002lke.1	-	2	3167	c.1943A>T	c.(1942-1944)GAT>GTT	p.D648V		NM_032160	NP_115536	Q8IZU8	DSEL_HUMAN	dermatan sulfate epimerase-like	638						integral to membrane	isomerase activity|sulfotransferase activity			ovary(3)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	6		Esophageal squamous(42;0.129)				GCCATGATGATCAAACCAAAA	0.348		NA											12	44					0	0	0	0
CARM1	10498	broad.mit.edu	37	19	11018790	11018790	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7413-01A-11D-2078-08	TCGA-CV-7413-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be482a19-0de0-4e60-a831-9ebe8545a6f3	741ec714-2c58-4d0c-a373-be69346da938	g.chr19:11018790C>T	uc002mpz.2	+	3	548	c.422C>T	c.(421-423)ACG>ATG	p.T141M	CARM1_uc010dxn.2_RNA	NM_199141	NP_954592	Q86X55	CARM1_HUMAN	coactivator-associated arginine	141					cellular lipid metabolic process|histone H3-R2 methylation|interspecies interaction between organisms|pathogenesis|positive regulation of fat cell differentiation|regulation of estrogen receptor signaling pathway|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nucleoplasm	beta-catenin binding|histone acetyl-lysine binding|histone methyltransferase activity (H3-R17 specific)|ligand-dependent nuclear receptor transcription coactivator activity|protein-arginine omega-N asymmetric methyltransferase activity|transcription regulatory region DNA binding				0						AGCGAGCGGACGGAGGAGTCT	0.637		NA											15	77					0	0	0	0
KANK2	25959	broad.mit.edu	37	19	11280802	11280802	+	Silent	SNP	G	G	A			TCGA-CV-7413-01A-11D-2078-08	TCGA-CV-7413-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be482a19-0de0-4e60-a831-9ebe8545a6f3	741ec714-2c58-4d0c-a373-be69346da938	g.chr19:11280802G>A	uc010dxv.2	-	13	2892	c.2334C>T	c.(2332-2334)TGC>TGT	p.C778C	KANK2_uc002mqm.2_Silent_p.C786C|KANK2_uc002mqo.3_Silent_p.C778C|KANK2_uc002mqp.1_Silent_p.C587C	NM_015493	NP_056308	Q63ZY3	KANK2_HUMAN	ankyrin repeat domain 25 isoform 1	778	ANK 4.										0						GCTCACAGGCGCACATGAGGG	0.637		NA											15	44					0	0	0	0
PAF1	54623	broad.mit.edu	37	19	39879970	39879970	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7413-01A-11D-2078-08	TCGA-CV-7413-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be482a19-0de0-4e60-a831-9ebe8545a6f3	741ec714-2c58-4d0c-a373-be69346da938	g.chr19:39879970G>A	uc002old.2	-	6	588	c.413C>T	c.(412-414)TCC>TTC	p.S138F	PAF1_uc002ole.1_Missense_Mutation_p.S128F|PAF1_uc010xuv.1_RNA|MED29_uc010xuw.1_5'Flank|MED29_uc002olf.2_5'Flank|MED29_uc010xux.1_5'Flank	NM_019088	NP_061961	Q8N7H5	PAF1_HUMAN	Paf1, RNA polymerase II associated factor,	138					histone H2B ubiquitination|histone monoubiquitination|regulation of transcription, DNA-dependent|transcription, DNA-dependent	Cdc73/Paf1 complex	protein binding			pancreas(1)	1	all_cancers(60;9.14e-07)|all_lung(34;4.03e-08)|Lung NSC(34;4.66e-08)|all_epithelial(25;1.88e-06)|Ovarian(47;0.0512)		Epithelial(26;9.6e-28)|all cancers(26;9.14e-25)|Lung(45;0.000168)|LUSC - Lung squamous cell carcinoma(53;0.000199)			GAACTCAGTGGAGATGTACTC	0.517		NA											11	53					0	0	0	0
KIR2DL3	3804	broad.mit.edu	37	19	55250985	55250985	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7413-01A-11D-2078-08	TCGA-CV-7413-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be482a19-0de0-4e60-a831-9ebe8545a6f3	741ec714-2c58-4d0c-a373-be69346da938	g.chr19:55250985G>A	uc002qgv.2	+	2	85	c.67G>A	c.(67-69)GAG>AAG	p.E23K	KIR2DL3_uc002qgx.2_Missense_Mutation_p.E23K|KIR2DL3_uc002qgy.2_Missense_Mutation_p.E23K|KIR2DL3_uc010erw.1_Missense_Mutation_p.E23K|KIR2DL1_uc002qgz.1_5'UTR|KIR2DL3_uc002qha.1_5'Flank	NM_015868	NP_056952	P43628	KI2L3_HUMAN	killer cell immunoglobulin-like receptor, two	23	Extracellular (Potential).				immune response|regulation of immune response	integral to plasma membrane	antigen binding|protein binding|receptor activity			ovary(2)	2				GBM - Glioblastoma multiforme(193;0.0192)		CTGGCCACATGAGGGTGAGTC	0.542		NA											19	77					0	0	0	0
NLRP7	199713	broad.mit.edu	37	19	55450492	55450492	+	Silent	SNP	C	C	G			TCGA-CV-7413-01A-11D-2078-08	TCGA-CV-7413-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be482a19-0de0-4e60-a831-9ebe8545a6f3	741ec714-2c58-4d0c-a373-be69346da938	g.chr19:55450492C>G	uc002qih.3	-	4	1771	c.1695G>C	c.(1693-1695)GTG>GTC	p.V565V	NLRP7_uc002qig.3_Silent_p.V565V|NLRP7_uc002qii.3_Silent_p.V565V|NLRP7_uc010esk.2_Silent_p.V565V|NLRP7_uc010esl.2_Silent_p.V593V	NM_206828	NP_996611	Q8WX94	NALP7_HUMAN	NACHT, leucine rich repeat and PYD containing 7	565							ATP binding			large_intestine(1)|breast(1)|central_nervous_system(1)	3				GBM - Glioblastoma multiforme(193;0.0325)		TCAGGTCGGTCACGGATAAGG	0.527		NA											21	39					0	0	0	0
NT5C1B	93034	broad.mit.edu	37	2	18757571	18757571	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7413-01A-11D-2078-08	TCGA-CV-7413-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be482a19-0de0-4e60-a831-9ebe8545a6f3	741ec714-2c58-4d0c-a373-be69346da938	g.chr2:18757571C>T	uc002rcz.2	-	9	1492	c.1388G>A	c.(1387-1389)CGT>CAT	p.R463H	NT5C1B_uc002rcy.2_Missense_Mutation_p.R463H|NT5C1B_uc010exr.2_Missense_Mutation_p.R405H|NT5C1B_uc010yju.1_Missense_Mutation_p.R403H|NT5C1B_uc002rda.2_Missense_Mutation_p.R403H|NT5C1B_uc010yjv.1_Missense_Mutation_p.R480H|NT5C1B_uc010yjw.1_Missense_Mutation_p.R446H|NT5C1B_uc010exs.2_Missense_Mutation_p.R465H	NM_001002006	NP_001002006	Q96P26	5NT1B_HUMAN	5' nucleotidase, cytosolic IB isoform 1	463					purine base metabolic process|purine nucleotide catabolic process	cytosol	5'-nucleotidase activity|magnesium ion binding|nucleotide binding			skin(2)|ovary(1)	3	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.177)	Ovarian(717;0.208)				AAAGGCTACACGGAGCTGAGT	0.443		NA											11	31					0	0	0	0
VWA3B	200403	broad.mit.edu	37	2	98914449	98914449	+	Silent	SNP	C	C	T			TCGA-CV-7413-01A-11D-2078-08	TCGA-CV-7413-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be482a19-0de0-4e60-a831-9ebe8545a6f3	741ec714-2c58-4d0c-a373-be69346da938	g.chr2:98914449C>T	uc002syo.2	+	24	3501	c.3237C>T	c.(3235-3237)TCC>TCT	p.S1079S	VWA3B_uc002syn.1_RNA|VWA3B_uc010yvi.1_Silent_p.S736S|VWA3B_uc002syp.1_Silent_p.S471S|VWA3B_uc002syq.1_Silent_p.S355S|VWA3B_uc002syr.1_Silent_p.S396S|VWA3B_uc002sys.2_RNA	NM_144992	NP_659429	Q502W6	VWA3B_HUMAN	von Willebrand factor A domain containing 3B	1079										ovary(3)|large_intestine(2)|skin(1)	6						TGTCCACCTCCTTCATCACGC	0.577		NA											9	59					0	0	0	0
LRP1B	53353	broad.mit.edu	37	2	141806672	141806672	+	Missense_Mutation	SNP	G	G	T			TCGA-CV-7413-01A-11D-2078-08	TCGA-CV-7413-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be482a19-0de0-4e60-a831-9ebe8545a6f3	741ec714-2c58-4d0c-a373-be69346da938	g.chr2:141806672G>T	uc002tvj.1	-	11	2644	c.1672C>A	c.(1672-1674)CCT>ACT	p.P558T	LRP1B_uc010fnl.1_Intron	NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	558	Extracellular (Potential).				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		AAAGCACGAGGGTTTACCAGA	0.438		NA								TSP Lung(27;0.18)			31	116					1.62e-16	1.84e-16	1	0
FIGN	55137	broad.mit.edu	37	2	164467771	164467771	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7413-01A-11D-2078-08	TCGA-CV-7413-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be482a19-0de0-4e60-a831-9ebe8545a6f3	741ec714-2c58-4d0c-a373-be69346da938	g.chr2:164467771C>T	uc002uck.1	-	3	882	c.571G>A	c.(571-573)GGA>AGA	p.G191R		NM_018086	NP_060556	Q5HY92	FIGN_HUMAN	fidgetin	191						nuclear matrix	ATP binding|nucleoside-triphosphatase activity			large_intestine(2)|ovary(1)|skin(1)	4						AAATATGATCCGTTGTATCCT	0.507		NA											6	39					0	0	0	0
CASP8	841	broad.mit.edu	37	2	202131394	202131394	+	Missense_Mutation	SNP	T	T	C			TCGA-CV-7413-01A-11D-2078-08	TCGA-CV-7413-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be482a19-0de0-4e60-a831-9ebe8545a6f3	741ec714-2c58-4d0c-a373-be69346da938	g.chr2:202131394T>C	uc002uxr.1	+	3	394	c.185T>C	c.(184-186)CTG>CCG	p.L62P	CASP8_uc010ftc.1_Missense_Mutation_p.L62P|CASP8_uc002uxo.1_Missense_Mutation_p.L62P|CASP8_uc002uxp.1_Missense_Mutation_p.L62P|CASP8_uc002uxq.1_Missense_Mutation_p.L62P|CASP8_uc002uxs.1_Missense_Mutation_p.L62P|CASP8_uc002uxt.1_Missense_Mutation_p.L121P|CASP8_uc002uxu.1_RNA|CASP8_uc010ftd.1_Intron|CASP8_uc002uxv.1_Missense_Mutation_p.L62P|CASP8_uc002uxw.1_Missense_Mutation_p.L62P|CASP8_uc002uxy.1_Missense_Mutation_p.L62P|CASP8_uc002uxx.1_Missense_Mutation_p.L62P|CASP8_uc010ftf.2_Missense_Mutation_p.L62P	NM_033355	NP_203519	Q14790	CASP8_HUMAN	caspase 8 isoform B precursor	62	DED 1.				activation of caspase activity|activation of pro-apoptotic gene products|cellular component disassembly involved in apoptosis|cellular response to mechanical stimulus|induction of apoptosis by extracellular signals|induction of apoptosis by intracellular signals|positive regulation of I-kappaB kinase/NF-kappaB cascade|proteolysis involved in cellular protein catabolic process|response to tumor necrosis factor	centrosome|cytosol|mitochondrial outer membrane	cysteine-type endopeptidase activity|protein binding|protein binding			upper_aerodigestive_tract(2)|ovary(1)|breast(1)|skin(1)	5						CTGTCCTTCCTGAAGGAGCTG	0.453		NA								HNSCC(4;0.00038)			6	23					0	0	0	0
NFATC2	4773	broad.mit.edu	37	20	50140118	50140118	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7413-01A-11D-2078-08	TCGA-CV-7413-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be482a19-0de0-4e60-a831-9ebe8545a6f3	741ec714-2c58-4d0c-a373-be69346da938	g.chr20:50140118G>A	uc002xwd.2	-	2	882	c.662C>T	c.(661-663)TCA>TTA	p.S221L	NFATC2_uc002xwc.2_Missense_Mutation_p.S221L|NFATC2_uc010zyv.1_Missense_Mutation_p.S2L|NFATC2_uc010zyw.1_Missense_Mutation_p.S2L|NFATC2_uc010zyx.1_Missense_Mutation_p.S201L|NFATC2_uc010zyy.1_Missense_Mutation_p.S2L|NFATC2_uc010zyz.1_Missense_Mutation_p.S2L|NFATC2_uc002xwe.2_Missense_Mutation_p.S201L	NM_173091	NP_775114	Q13469	NFAC2_HUMAN	nuclear factor of activated T-cells,	221	3 X approximate SP repeats.|2.				B cell receptor signaling pathway|positive regulation of B cell proliferation|response to DNA damage stimulus|response to drug	actin cytoskeleton|nucleus|plasma membrane	protein binding|sequence-specific DNA binding transcription factor activity			ovary(2)	2	Hepatocellular(150;0.248)					GGTTCGAGGTGACATTATTGG	0.652		NA											20	71					0	0	0	0
KRTAP6-3	337968	broad.mit.edu	37	21	31965096	31965096	+	Silent	SNP	G	G	A			TCGA-CV-7413-01A-11D-2078-08	TCGA-CV-7413-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be482a19-0de0-4e60-a831-9ebe8545a6f3	741ec714-2c58-4d0c-a373-be69346da938	g.chr21:31965096G>A	uc002yom.2	+	1	338	c.332G>A	c.(331-333)TGA>TAA	p.*111*		NM_181605	NP_853636			keratin associated protein 6-3												0						TACTACTATTGAGGACACCAT	0.443		NA											3	11					0	0	0	0
CECR1	51816	broad.mit.edu	37	22	17669265	17669265	+	Missense_Mutation	SNP	C	C	T	rs74317375	byFrequency	TCGA-CV-7413-01A-11D-2078-08	TCGA-CV-7413-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be482a19-0de0-4e60-a831-9ebe8545a6f3	741ec714-2c58-4d0c-a373-be69346da938	g.chr22:17669265C>T	uc002zmk.1	-	6	1257	c.1045G>A	c.(1045-1047)GTT>ATT	p.V349I	CECR1_uc010gqu.1_Missense_Mutation_p.V349I|CECR1_uc011agi.1_Missense_Mutation_p.V307I|CECR1_uc002zmj.1_Missense_Mutation_p.V108I	NM_017424	NP_059120	Q9NZK5	CECR1_HUMAN	cat eye syndrome critical region protein 1	349					adenosine catabolic process|hypoxanthine salvage|inosine biosynthetic process|multicellular organismal development|purine ribonucleoside monophosphate biosynthetic process	extracellular space|Golgi apparatus	adenosine deaminase activity|adenosine receptor binding|growth factor activity|heparin binding|protein homodimerization activity|proteoglycan binding|zinc ion binding			ovary(1)	1		all_epithelial(15;0.0152)|Lung NSC(13;0.0875)|all_lung(157;0.106)				GGCAGCTTAACGCCATCCTTG	0.607		NA											3	51					0	0	0	0
ERC2	26059	broad.mit.edu	37	3	56044571	56044571	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7413-01A-11D-2078-08	TCGA-CV-7413-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be482a19-0de0-4e60-a831-9ebe8545a6f3	741ec714-2c58-4d0c-a373-be69346da938	g.chr3:56044571C>T	uc003dhr.1	-	9	2082	c.1826G>A	c.(1825-1827)CGG>CAG	p.R609Q	ERC2_uc003dht.1_Missense_Mutation_p.R80Q	NM_015576	NP_056391	O15083	ERC2_HUMAN	cytomatrix protein p110	609	Potential.					cell junction|cytoplasm|cytoskeleton|growth cone|presynaptic membrane|synaptosome	protein binding			ovary(2)	2				KIRC - Kidney renal clear cell carcinoma(284;0.0667)|Kidney(284;0.0873)|OV - Ovarian serous cystadenocarcinoma(275;0.219)		TAGTCTTTCCCGATCATCTCT	0.413		NA											13	49					0	0	0	0
TIPARP	25976	broad.mit.edu	37	3	156396202	156396202	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7413-01A-11D-2078-08	TCGA-CV-7413-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be482a19-0de0-4e60-a831-9ebe8545a6f3	741ec714-2c58-4d0c-a373-be69346da938	g.chr3:156396202G>A	uc003fav.2	+	2	964	c.716G>A	c.(715-717)GGA>GAA	p.G239E	LOC100287227_uc011boq.1_5'Flank|TIPARP_uc003faw.2_Missense_Mutation_p.G239E	NM_015508	NP_056323	Q7Z3E1	PARPT_HUMAN	TCDD-inducible poly(ADP-ribose) polymerase	239	C3H1-type.						NAD+ ADP-ribosyltransferase activity|nucleic acid binding|protein binding|zinc ion binding			ovary(1)|breast(1)	2			LUSC - Lung squamous cell carcinoma(72;0.0461)|Lung(72;0.0465)			CAAGAGAACGGAATTGAAATT	0.458		NA											22	127					0	0	0	0
FAT4	79633	broad.mit.edu	37	4	126371855	126371855	+	Silent	SNP	G	G	C			TCGA-CV-7413-01A-11D-2078-08	TCGA-CV-7413-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be482a19-0de0-4e60-a831-9ebe8545a6f3	741ec714-2c58-4d0c-a373-be69346da938	g.chr4:126371855G>C	uc003ifj.3	+	9	9684	c.9684G>C	c.(9682-9684)GTG>GTC	p.V3228V	FAT4_uc011cgp.1_Silent_p.V1526V|FAT4_uc003ifi.1_Silent_p.V706V	NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	3228	Cadherin 31.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18						CAAATGCTGTGATTGCGTATA	0.428		NA											9	50					0	0	0	0
LRBA	987	broad.mit.edu	37	4	151842388	151842388	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7413-01A-11D-2078-08	TCGA-CV-7413-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be482a19-0de0-4e60-a831-9ebe8545a6f3	741ec714-2c58-4d0c-a373-be69346da938	g.chr4:151842388G>A	uc010ipj.2	-	5	1081	c.607C>T	c.(607-609)CCT>TCT	p.P203S	LRBA_uc003ilu.3_Missense_Mutation_p.P203S|LRBA_uc010ipk.1_Missense_Mutation_p.P122S	NM_006726	NP_006717	P50851	LRBA_HUMAN	LPS-responsive vesicle trafficking, beach and	203						endoplasmic reticulum|Golgi apparatus|integral to membrane|lysosome|plasma membrane	protein binding			ovary(3)|breast(3)|skin(1)	7	all_hematologic(180;0.151)					AAGGCATCAGGACCATACTTC	0.383		NA											25	52					0	0	0	0
FAT1	2195	broad.mit.edu	37	4	187549812	187549812	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CV-7413-01A-11D-2078-08	TCGA-CV-7413-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be482a19-0de0-4e60-a831-9ebe8545a6f3	741ec714-2c58-4d0c-a373-be69346da938	g.chr4:187549812G>A	uc003izf.2	-	8	4617	c.4429C>T	c.(4429-4431)CAA>TAA	p.Q1477*		NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor	1477	Extracellular (Potential).|Cadherin 13.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12						GCACTGATTTGCAAAATTTCT	0.393		NA								HNSCC(5;0.00058)			9	27					0	0	0	0
TRIO	7204	broad.mit.edu	37	5	14488246	14488246	+	Silent	SNP	G	G	C			TCGA-CV-7413-01A-11D-2078-08	TCGA-CV-7413-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be482a19-0de0-4e60-a831-9ebe8545a6f3	741ec714-2c58-4d0c-a373-be69346da938	g.chr5:14488246G>C	uc003jff.2	+	48	7515	c.7509G>C	c.(7507-7509)CCG>CCC	p.P2503P	TRIO_uc003jfg.2_Intron|TRIO_uc003jfh.1_Silent_p.P2152P	NM_007118	NP_009049	O75962	TRIO_HUMAN	triple functional domain (PTPRF interacting)	2503					apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|transmembrane receptor protein tyrosine phosphatase signaling pathway	cytosol	ATP binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			skin(4)|central_nervous_system(3)|ovary(3)|large_intestine(2)|stomach(2)|breast(2)|upper_aerodigestive_tract(1)|kidney(1)	18	Lung NSC(4;0.000742)					TCACCTTCCCGGGGGACAGCG	0.721		NA											4	15					0	0	0	0
GPBP1	65056	broad.mit.edu	37	5	56546884	56546884	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7413-01A-11D-2078-08	TCGA-CV-7413-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be482a19-0de0-4e60-a831-9ebe8545a6f3	741ec714-2c58-4d0c-a373-be69346da938	g.chr5:56546884C>T	uc003jrh.3	+	10	2350	c.1076C>T	c.(1075-1077)GCC>GTC	p.A359V	GPBP1_uc010iwg.2_Missense_Mutation_p.A379V|GPBP1_uc003jri.3_Missense_Mutation_p.A188V|GPBP1_uc003jrj.3_Missense_Mutation_p.A351V|GPBP1_uc003jrk.3_Missense_Mutation_p.A366V|GPBP1_uc003jrl.3_RNA	NM_022913	NP_075064	Q86WP2	GPBP1_HUMAN	GC-rich promoter binding protein 1 isoform 1	359					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding			large_intestine(1)|central_nervous_system(1)	2		Lung NSC(810;0.000861)|Prostate(74;0.0305)|Breast(144;0.222)		OV - Ovarian serous cystadenocarcinoma(10;7.64e-39)		AATGGCAATGCCTCAGTGATT	0.393		NA											19	37					0	0	0	0
RASA1	5921	broad.mit.edu	37	5	86681171	86681171	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CV-7413-01A-11D-2078-08	TCGA-CV-7413-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be482a19-0de0-4e60-a831-9ebe8545a6f3	741ec714-2c58-4d0c-a373-be69346da938	g.chr5:86681171C>T	uc003kiw.2	+	22	2930	c.2812C>T	c.(2812-2814)CAG>TAG	p.Q938*	RASA1_uc010jav.2_RNA|RASA1_uc003kix.2_Nonsense_Mutation_p.Q761*|RASA1_uc011ctv.1_Nonsense_Mutation_p.Q771*|RASA1_uc011ctw.1_Nonsense_Mutation_p.Q772*|RASA1_uc010jaw.2_Nonsense_Mutation_p.Q760*	NM_002890	NP_002881	P20936	RASA1_HUMAN	RAS p21 protein activator 1 isoform 1	938	Ras-GAP.				cytokinesis|embryo development|intracellular signal transduction|negative regulation of cell-matrix adhesion|negative regulation of neuron apoptosis|negative regulation of Ras protein signal transduction|positive regulation of anti-apoptosis|regulation of actin filament polymerization|regulation of cell shape|regulation of RNA metabolic process|vasculogenesis	cytosol|intrinsic to internal side of plasma membrane	glycoprotein binding|GTPase binding|potassium channel inhibitor activity|Ras GTPase activator activity|receptor binding			upper_aerodigestive_tract(3)|ovary(1)|lung(1)	5		all_cancers(142;8.25e-07)|Lung NSC(167;0.000185)|all_lung(232;0.000222)|Colorectal(57;0.00542)|Ovarian(174;0.0423)		OV - Ovarian serous cystadenocarcinoma(54;4.72e-41)|Epithelial(54;1.51e-36)|all cancers(79;3.76e-31)		TAAATCTGTGCAGAACTTAGC	0.353		NA											4	24					0	0	0	0
AFF4	27125	broad.mit.edu	37	5	132269973	132269973	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7413-01A-11D-2078-08	TCGA-CV-7413-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be482a19-0de0-4e60-a831-9ebe8545a6f3	741ec714-2c58-4d0c-a373-be69346da938	g.chr5:132269973C>T	uc003kyd.2	-	3	1192	c.784G>A	c.(784-786)GGA>AGA	p.G262R	AFF4_uc011cxk.1_5'UTR|AFF4_uc003kye.1_Missense_Mutation_p.G262R|AFF4_uc003kyf.3_Missense_Mutation_p.G262R	NM_014423	NP_055238	Q9UHB7	AFF4_HUMAN	ALL1 fused gene from 5q31	262	Ser-rich.				transcription from RNA polymerase II promoter	mitochondrion|nucleolus	protein binding|sequence-specific DNA binding transcription factor activity			ovary(2)|kidney(2)|skin(1)	5		all_cancers(142;0.145)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			GACTCCTGTCCGTCCATGGGC	0.512		NA											15	61					0	0	0	0
PCDHB2	56133	broad.mit.edu	37	5	140475797	140475797	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7413-01A-11D-2078-08	TCGA-CV-7413-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be482a19-0de0-4e60-a831-9ebe8545a6f3	741ec714-2c58-4d0c-a373-be69346da938	g.chr5:140475797G>A	uc003lil.2	+	1	1561	c.1423G>A	c.(1423-1425)GTC>ATC	p.V475I	PCDHB2_uc003lim.1_Missense_Mutation_p.V136I	NM_018936	NP_061759	Q9Y5E7	PCDB2_HUMAN	protocadherin beta 2 precursor	475	Extracellular (Potential).|Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			ovary(3)|upper_aerodigestive_tract(2)|pancreas(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CATCGGCAGCGTCAGCGCCAC	0.667		NA											34	117					0	0	0	0
PCDHB2	56133	broad.mit.edu	37	5	140476357	140476357	+	Silent	SNP	C	C	T			TCGA-CV-7413-01A-11D-2078-08	TCGA-CV-7413-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be482a19-0de0-4e60-a831-9ebe8545a6f3	741ec714-2c58-4d0c-a373-be69346da938	g.chr5:140476357C>T	uc003lil.2	+	1	2121	c.1983C>T	c.(1981-1983)CAC>CAT	p.H661H	PCDHB2_uc003lim.1_Silent_p.H322H	NM_018936	NP_061759	Q9Y5E7	PCDB2_HUMAN	protocadherin beta 2 precursor	661	Cadherin 6.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			ovary(3)|upper_aerodigestive_tract(2)|pancreas(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CCACGCTGCACGTGCTCCTGG	0.711		NA											5	58					0	0	0	0
PCDHB13	56123	broad.mit.edu	37	5	140595724	140595724	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7413-01A-11D-2078-08	TCGA-CV-7413-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be482a19-0de0-4e60-a831-9ebe8545a6f3	741ec714-2c58-4d0c-a373-be69346da938	g.chr5:140595724G>C	uc003lja.1	+	1	2216	c.2029G>C	c.(2029-2031)GCC>CCC	p.A677P		NM_018933	NP_061756	Q9Y5F0	PCDBD_HUMAN	protocadherin beta 13 precursor	677	Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			skin(2)|ovary(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CCCGGAGGCGGCCCCGACCCA	0.682		NA											36	114					0	0	0	0
ODZ2	57451	broad.mit.edu	37	5	167673804	167673804	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7413-01A-11D-2078-08	TCGA-CV-7413-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be482a19-0de0-4e60-a831-9ebe8545a6f3	741ec714-2c58-4d0c-a373-be69346da938	g.chr5:167673804G>A	uc010jjd.2	+	27	5833	c.5833G>A	c.(5833-5835)GAG>AAG	p.E1945K	ODZ2_uc003lzr.3_Missense_Mutation_p.E1715K|ODZ2_uc003lzt.3_Missense_Mutation_p.E1318K|ODZ2_uc010jje.2_Missense_Mutation_p.E1209K	NM_001122679	NP_001116151			odz, odd Oz/ten-m homolog 2											ovary(6)|central_nervous_system(4)	10	Renal(175;0.00124)|Lung NSC(126;0.136)|all_lung(126;0.242)	Medulloblastoma(196;0.0241)|all_neural(177;0.026)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0444)|OV - Ovarian serous cystadenocarcinoma(192;0.0694)|Epithelial(171;0.124)		GTATATATTTGAGTATGACTC	0.512		NA											68	223					0	0	0	0
HIST1H4F	8361	broad.mit.edu	37	6	26240713	26240713	+	Silent	SNP	C	C	T			TCGA-CV-7413-01A-11D-2078-08	TCGA-CV-7413-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be482a19-0de0-4e60-a831-9ebe8545a6f3	741ec714-2c58-4d0c-a373-be69346da938	g.chr6:26240713C>T	uc003nhe.1	+	1	60	c.60C>T	c.(58-60)CGC>CGT	p.R20R		NM_003540	NP_003531	P62805	H4_HUMAN	histone cluster 1, H4f	20					CenH3-containing nucleosome assembly at centromere|negative regulation of megakaryocyte differentiation|phosphatidylinositol-mediated signaling|telomere maintenance	nucleoplasm|nucleosome	DNA binding|protein binding				0		all_hematologic(11;0.0945)|Acute lymphoblastic leukemia(11;0.167)				AGCGCCATCGCAAAGTGCTGC	0.537		NA											5	18					0	0	0	0
HIST1H1B	3009	broad.mit.edu	37	6	27834874	27834874	+	Missense_Mutation	SNP	G	G	T			TCGA-CV-7413-01A-11D-2078-08	TCGA-CV-7413-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be482a19-0de0-4e60-a831-9ebe8545a6f3	741ec714-2c58-4d0c-a373-be69346da938	g.chr6:27834874G>T	uc003njx.2	-	1	486	c.434C>A	c.(433-435)GCT>GAT	p.A145D		NM_005322	NP_005313	P16401	H15_HUMAN	histone cluster 1, H1b	145					nucleosome assembly	nucleosome|nucleus	DNA binding			large_intestine(2)|lung(1)	3						CGCCCCTGCAGCCTTCTTGGC	0.617		NA											41	192					9.85e-19	1.13e-18	1	0
TCTE1	202500	broad.mit.edu	37	6	44254022	44254022	+	Silent	SNP	C	C	T			TCGA-CV-7413-01A-11D-2078-08	TCGA-CV-7413-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be482a19-0de0-4e60-a831-9ebe8545a6f3	741ec714-2c58-4d0c-a373-be69346da938	g.chr6:44254022C>T	uc003oxi.2	-	3	681	c.525G>A	c.(523-525)GCG>GCA	p.A175A	SPATS1_uc003oxg.2_Intron|TMEM151B_uc003oxf.2_Intron	NM_182539	NP_872345	Q5JU00	TCTE1_HUMAN	t-complex-associated testis expressed 1	175										ovary(2)|skin(2)	4	Hepatocellular(11;0.00908)|all_lung(25;0.0101)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)			CGAGGATCACCGCAGGGTCTG	0.652		NA											20	41					0	0	0	0
GRM8	2918	broad.mit.edu	37	7	126746580	126746580	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7413-01A-11D-2078-08	TCGA-CV-7413-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be482a19-0de0-4e60-a831-9ebe8545a6f3	741ec714-2c58-4d0c-a373-be69346da938	g.chr7:126746580C>T	uc003vlr.2	-	2	1008	c.697G>A	c.(697-699)GAG>AAG	p.E233K	GRM8_uc003vls.2_RNA|GRM8_uc011kof.1_RNA|GRM8_uc003vlt.2_Missense_Mutation_p.E233K|GRM8_uc010lkz.1_RNA|GRM8_uc003vlu.1_5'UTR	NM_000845	NP_000836	O00222	GRM8_HUMAN	glutamate receptor, metabotropic 8 isoform a	233	Extracellular (Potential).				negative regulation of cAMP biosynthetic process|sensory perception of smell|visual perception	integral to plasma membrane				lung(15)|ovary(5)|pancreas(1)|breast(1)|skin(1)	23		Prostate(267;0.186)			L-Glutamic Acid(DB00142)	GTGAAGGCCTCCACACCGCTC	0.498		NA								HNSCC(24;0.065)			7	20					0	0	0	0
TNKS	8658	broad.mit.edu	37	8	9605599	9605599	+	Silent	SNP	G	G	A	rs35491087	byFrequency	TCGA-CV-7413-01A-11D-2078-08	TCGA-CV-7413-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be482a19-0de0-4e60-a831-9ebe8545a6f3	741ec714-2c58-4d0c-a373-be69346da938	g.chr8:9605599G>A	uc003wss.2	+	18	2714	c.2709G>A	c.(2707-2709)GCG>GCA	p.A903A	TNKS_uc011kww.1_Silent_p.A666A|TNKS_uc010lrt.1_RNA	NM_003747	NP_003738	O95271	TNKS1_HUMAN	tankyrase, TRF1-interacting ankyrin-related	903	ANK 15.				mitotic spindle organization|mRNA transport|negative regulation of DNA binding|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of telomere maintenance via telomerase|protein auto-ADP-ribosylation|protein localization to chromosome, telomeric region|protein poly-ADP-ribosylation|protein polyubiquitination|protein transport|spindle assembly|transmembrane transport|Wnt receptor signaling pathway	chromosome, centromeric region|Golgi membrane|microsome|nuclear chromosome, telomeric region|nuclear membrane|nuclear pore|pericentriolar material	NAD+ ADP-ribosyltransferase activity|protein binding|zinc ion binding			lung(4)|ovary(2)|kidney(1)	7				COAD - Colon adenocarcinoma(149;0.0467)		ATAAGTGGGCGTTTACTCCCC	0.473		NA											8	31					0	0	0	0
HR	55806	broad.mit.edu	37	8	21976769	21976769	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7413-01A-11D-2078-08	TCGA-CV-7413-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be482a19-0de0-4e60-a831-9ebe8545a6f3	741ec714-2c58-4d0c-a373-be69346da938	g.chr8:21976769C>T	uc003xas.2	-	15	3670	c.3005G>A	c.(3004-3006)GGG>GAG	p.G1002E	HR_uc003xat.2_Missense_Mutation_p.G1002E	NM_005144	NP_005135	O43593	HAIR_HUMAN	hairless protein isoform a	1002	JmjC.						DNA binding|metal ion binding|sequence-specific DNA binding transcription factor activity			large_intestine(1)|ovary(1)	2		Breast(100;0.000162)|Acute lymphoblastic leukemia(644;0.0775)|Prostate(55;0.116)		KIRC - Kidney renal clear cell carcinoma(542;1.19e-05)|BRCA - Breast invasive adenocarcinoma(99;3.56e-05)|Colorectal(74;0.00191)|COAD - Colon adenocarcinoma(73;0.0615)|READ - Rectum adenocarcinoma(644;0.1)		GTTCTTGGTCCCCAGGTGTCC	0.502		NA											6	34					0	0	0	0
ADAM28	10863	broad.mit.edu	37	8	24209561	24209561	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7413-01A-11D-2078-08	TCGA-CV-7413-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be482a19-0de0-4e60-a831-9ebe8545a6f3	741ec714-2c58-4d0c-a373-be69346da938	g.chr8:24209561C>G	uc003xdy.2	+	21	2323	c.2240C>G	c.(2239-2241)TCT>TGT	p.S747C	ADAM28_uc011laa.1_RNA|ADAM28_uc010lua.2_Missense_Mutation_p.S434C	NM_014265	NP_055080	Q9UKQ2	ADA28_HUMAN	ADAM metallopeptidase domain 28 isoform 1	747	Cytoplasmic (Potential).				proteolysis|spermatogenesis	extracellular region|integral to membrane|plasma membrane	metalloendopeptidase activity|zinc ion binding			skin(3)|lung(1)|central_nervous_system(1)	5		Prostate(55;0.0959)		Colorectal(74;0.0129)|COAD - Colon adenocarcinoma(73;0.0434)|BRCA - Breast invasive adenocarcinoma(99;0.175)		CCCCCAGCCTCTTTTGTGAGT	0.408		NA											9	58					0	0	0	0
RBM12B	389677	broad.mit.edu	37	8	94746535	94746535	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7413-01A-11D-2078-08	TCGA-CV-7413-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be482a19-0de0-4e60-a831-9ebe8545a6f3	741ec714-2c58-4d0c-a373-be69346da938	g.chr8:94746535G>A	uc003yfz.2	-	3	2297	c.2104C>T	c.(2104-2106)CCC>TCC	p.P702S		NM_203390	NP_976324	Q8IXT5	RB12B_HUMAN	RNA binding motif protein 12B	702							nucleotide binding|RNA binding				0	Breast(36;4.14e-07)		BRCA - Breast invasive adenocarcinoma(8;0.0168)			TCCTCTGGGGGCCGCCTGAAG	0.642		NA											34	124					0	0	0	0
KCNQ3	3786	broad.mit.edu	37	8	133141591	133141591	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7413-01A-11D-2078-08	TCGA-CV-7413-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be482a19-0de0-4e60-a831-9ebe8545a6f3	741ec714-2c58-4d0c-a373-be69346da938	g.chr8:133141591G>A	uc003ytj.2	-	15	2762	c.2537C>T	c.(2536-2538)ACG>ATG	p.T846M	KCNQ3_uc010mdt.2_Missense_Mutation_p.T834M|uc003yti.2_5'Flank	NM_004519	NP_004510	O43525	KCNQ3_HUMAN	potassium voltage-gated channel KQT-like protein	846					axon guidance|synaptic transmission	voltage-gated potassium channel complex	voltage-gated potassium channel activity			ovary(2)|breast(1)|central_nervous_system(1)|skin(1)	5	Esophageal squamous(12;0.00507)|Ovarian(258;0.00579)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000311)			GCCGCTGGGCGTGAAGGGGTC	0.572		NA											8	34					0	0	0	0
OPLAH	26873	broad.mit.edu	37	8	145107418	145107418	+	Silent	SNP	G	G	A			TCGA-CV-7413-01A-11D-2078-08	TCGA-CV-7413-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be482a19-0de0-4e60-a831-9ebe8545a6f3	741ec714-2c58-4d0c-a373-be69346da938	g.chr8:145107418G>A	uc003zar.3	-	23	3319	c.3237C>T	c.(3235-3237)AAC>AAT	p.N1079N		NM_017570	NP_060040	O14841	OPLA_HUMAN	5-oxoprolinase (ATP-hydrolysing)	1079							5-oxoprolinase (ATP-hydrolyzing) activity|ATP binding				0	all_cancers(97;1.06e-10)|all_epithelial(106;1.5e-09)|Lung NSC(106;5.89e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;6.79e-41)|Epithelial(56;1.02e-39)|all cancers(56;2.24e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)		L-Glutamic Acid(DB00142)	ACGTGAGCACGTTGCCGCCCA	0.771		NA											3	7					0	0	0	0
DOCK8	81704	broad.mit.edu	37	9	382632	382632	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7413-01A-11D-2078-08	TCGA-CV-7413-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be482a19-0de0-4e60-a831-9ebe8545a6f3	741ec714-2c58-4d0c-a373-be69346da938	g.chr9:382632G>A	uc003zgf.2	+	22	2837	c.2725G>A	c.(2725-2727)GCG>ACG	p.A909T	DOCK8_uc010mgu.2_Missense_Mutation_p.A211T|DOCK8_uc010mgv.2_Missense_Mutation_p.A841T|DOCK8_uc010mgw.1_Missense_Mutation_p.A211T|DOCK8_uc003zgk.2_Missense_Mutation_p.A367T	NM_203447	NP_982272	Q8NF50	DOCK8_HUMAN	dedicator of cytokinesis 8	909					blood coagulation	cytosol	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			ovary(3)|central_nervous_system(3)	6		all_cancers(5;2.13e-17)|all_epithelial(5;2.15e-12)|all_lung(10;6.69e-11)|Lung NSC(10;1.08e-10)|Acute lymphoblastic leukemia(5;0.000242)|all_hematologic(5;0.00317)|Breast(48;0.0151)|Prostate(43;0.128)		all cancers(5;9.3e-07)|GBM - Glioblastoma multiforme(5;2.41e-06)|Epithelial(6;0.00557)|Lung(218;0.00942)		CCCAGACCTCGCGGGGACACA	0.542		NA											7	30					0	0	0	0
CDKN2A	1029	broad.mit.edu	37	9	21971028	21971028	+	Nonsense_Mutation	SNP	C	C	T	rs121913389		TCGA-CV-7413-01A-11D-2078-08	TCGA-CV-7413-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be482a19-0de0-4e60-a831-9ebe8545a6f3	741ec714-2c58-4d0c-a373-be69346da938	g.chr9:21971028C>T	uc003zpk.2	-	2	542	c.330G>A	c.(328-330)TGG>TGA	p.W110*	MTAP_uc003zpi.1_Intron|CDKN2A_uc003zpj.2_3'UTR|CDKN2A_uc010miu.2_RNA|CDKN2A_uc003zpl.2_Missense_Mutation_p.G166R	NM_000077	NP_000068	P42771	CD2A1_HUMAN	cyclin-dependent kinase inhibitor 2A isoform 1	110	ANK 4.				cell cycle arrest|cell cycle checkpoint|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of cell-matrix adhesion|negative regulation of cyclin-dependent protein kinase activity|negative regulation of NF-kappaB transcription factor activity|positive regulation of macrophage apoptosis|positive regulation of smooth muscle cell apoptosis|Ras protein signal transduction|replicative senescence	cytosol|nucleus	cyclin-dependent protein kinase inhibitor activity|NF-kappaB binding|protein binding|protein binding|protein kinase binding	p.0?(1112)|p.W110*(38)|p.?(13)|p.H83fs*2(2)|p.W110fs*9(1)|p.D105fs*8(1)|p.A68fs*3(1)|p.R107fs*33(1)|p.W110fs*36(1)|p.W110C(1)		haematopoietic_and_lymphoid_tissue(647)|skin(419)|upper_aerodigestive_tract(414)|central_nervous_system(381)|lung(325)|pancreas(244)|oesophagus(230)|urinary_tract(225)|pleura(94)|liver(91)|soft_tissue(79)|bone(77)|ovary(76)|biliary_tract(71)|stomach(46)|breast(46)|kidney(39)|NS(28)|thyroid(24)|cervix(23)|meninges(18)|genital_tract(15)|endometrium(13)|prostate(11)|autonomic_ganglia(10)|salivary_gland(10)|large_intestine(9)|adrenal_gland(6)|eye(4)|vulva(2)|small_intestine(1)	3678		all_cancers(5;0)|Acute lymphoblastic leukemia(3;0)|all_hematologic(3;0)|all_epithelial(2;2.37e-290)|Lung NSC(2;1.26e-139)|all_lung(2;4.48e-131)|Glioma(2;3.26e-60)|all_neural(2;2.1e-52)|Renal(3;1.07e-46)|Esophageal squamous(3;3.83e-46)|Melanoma(2;2.74e-34)|Breast(3;1.14e-11)|Ovarian(3;0.000128)|Hepatocellular(5;0.00162)|Colorectal(97;0.172)		all cancers(2;0)|GBM - Glioblastoma multiforme(3;0)|Lung(2;4.07e-74)|Epithelial(2;1.08e-61)|LUSC - Lung squamous cell carcinoma(2;3.82e-48)|LUAD - Lung adenocarcinoma(2;4.56e-26)|OV - Ovarian serous cystadenocarcinoma(39;7.64e-10)|BRCA - Breast invasive adenocarcinoma(2;5.01e-09)|STAD - Stomach adenocarcinoma(4;4.63e-07)|Kidney(2;5.79e-07)|KIRC - Kidney renal clear cell carcinoma(2;7.27e-07)|COAD - Colon adenocarcinoma(8;5.15e-05)		GCAGACGGCCCCAGGCATCGC	0.736		17							Uveal_Melanoma_Familial|Familial_Malignant_Melanoma_and_Tumors_of_the_Nervous_System|Hereditary_Melanoma	HNSCC(2;<9.43e_08)|TSP Lung(5;3.83e-07)			10	17					0	0	0	0
CCDC107	203260	broad.mit.edu	37	9	35658653	35658653	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7413-01A-11D-2078-08	TCGA-CV-7413-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be482a19-0de0-4e60-a831-9ebe8545a6f3	741ec714-2c58-4d0c-a373-be69346da938	g.chr9:35658653G>A	uc011lox.1	+	2	253	c.187G>A	c.(187-189)GCC>ACC	p.A63T	RMRP_uc003zxh.1_5'Flank|CCDC107_uc010mkx.1_Missense_Mutation_p.A63T|CCDC107_uc011loy.1_Missense_Mutation_p.A63T|CCDC107_uc003zxj.2_Missense_Mutation_p.A63T|CCDC107_uc003zxk.2_Missense_Mutation_p.A63T	NM_174923	NP_777583	Q8WV48	CC107_HUMAN	coiled-coil domain containing 107 precursor	63						integral to membrane					0	all_epithelial(49;0.217)		Lung(28;0.00276)|LUSC - Lung squamous cell carcinoma(32;0.00418)|STAD - Stomach adenocarcinoma(86;0.194)			GCGGACCCGGGCCGGGTCGCT	0.716		NA											8	13					0	0	0	0
ZNF189	7743	broad.mit.edu	37	9	104170879	104170879	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7413-01A-11D-2078-08	TCGA-CV-7413-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be482a19-0de0-4e60-a831-9ebe8545a6f3	741ec714-2c58-4d0c-a373-be69346da938	g.chr9:104170879G>A	uc004bbh.1	+	3	1105	c.829G>A	c.(829-831)GAG>AAG	p.E277K	ZNF189_uc004bbg.1_Missense_Mutation_p.E235K|ZNF189_uc004bbi.1_Missense_Mutation_p.E263K|ZNF189_uc011lvk.1_Missense_Mutation_p.E262K	NM_003452	NP_003443	O75820	ZN189_HUMAN	zinc finger protein 189 isoform 1	277	C2H2-type 5.				negative regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)|skin(2)|kidney(1)|central_nervous_system(1)	6		Acute lymphoblastic leukemia(62;0.0559)				ACACCTTATTGAGCATCAAAG	0.393		NA											55	106					0	0	0	0
PSMB7	5695	broad.mit.edu	37	9	127177670	127177670	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7413-01A-11D-2078-08	TCGA-CV-7413-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be482a19-0de0-4e60-a831-9ebe8545a6f3	741ec714-2c58-4d0c-a373-be69346da938	g.chr9:127177670C>T	uc004boj.2	-	1	52	c.35G>A	c.(34-36)GGA>GAA	p.G12E	PSMB7_uc010mwm.2_Missense_Mutation_p.G12E	NM_002799	NP_002790	Q99436	PSB7_HUMAN	proteasome beta 7 subunit proprotein	12					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|interspecies interaction between organisms|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	cytoplasm|nucleus|proteasome core complex	threonine-type endopeptidase activity				0						AGAGAAGCCTCCAACTGGTGG	0.607		NA									OREG0019476	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	7	13					0	0	0	0
NHS	4810	broad.mit.edu	37	X	17744146	17744146	+	Silent	SNP	G	G	A			TCGA-CV-7413-01A-11D-2078-08	TCGA-CV-7413-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be482a19-0de0-4e60-a831-9ebe8545a6f3	741ec714-2c58-4d0c-a373-be69346da938	g.chrX:17744146G>A	uc004cxx.2	+	6	2195	c.1857G>A	c.(1855-1857)ACG>ACA	p.T619T	NHS_uc011mix.1_Silent_p.T640T|NHS_uc004cxy.2_Silent_p.T463T|NHS_uc004cxz.2_Silent_p.T442T|NHS_uc004cya.2_Silent_p.T342T	NM_198270	NP_938011	Q6T4R5	NHS_HUMAN	Nance-Horan syndrome protein isoform 1	619						nucleus				skin(3)|ovary(2)|breast(1)|central_nervous_system(1)	7	Hepatocellular(33;0.183)					GCAGCTCCACGTGCCCCTCGC	0.582		NA											26	100					0	0	0	0
ZCCHC13	389874	broad.mit.edu	37	X	73524270	73524270	+	Missense_Mutation	SNP	G	G	T			TCGA-CV-7413-01A-11D-2078-08	TCGA-CV-7413-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be482a19-0de0-4e60-a831-9ebe8545a6f3	741ec714-2c58-4d0c-a373-be69346da938	g.chrX:73524270G>T	uc004ebs.3	+	1	246	c.169G>T	c.(169-171)GCT>TCT	p.A57S		NM_203303	NP_976048	Q8WW36	ZCH13_HUMAN	zinc finger, CCHC domain containing 13	57	CCHC-type 2; degenerate.						nucleic acid binding|zinc ion binding				0						CGGTCGTAATGCTAAGAACTG	0.527		NA											6	27					0.00116845	0.00124669	1	0
RNF128	79589	broad.mit.edu	37	X	105937342	105937342	+	Missense_Mutation	SNP	A	A	G			TCGA-CV-7413-01A-11D-2078-08	TCGA-CV-7413-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be482a19-0de0-4e60-a831-9ebe8545a6f3	741ec714-2c58-4d0c-a373-be69346da938	g.chrX:105937342A>G	uc004emk.2	+	1	275	c.110A>G	c.(109-111)TAC>TGC	p.Y37C		NM_024539	NP_078815	Q8TEB7	RN128_HUMAN	ring finger protein 128 isoform 2	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment						endomembrane system|integral to membrane|perinuclear region of cytoplasm	zinc ion binding			ovary(1)|central_nervous_system(1)	2						GTGACTTATTACAATGAAACC	0.388		NA											24	90					0	0	0	0
AFF2	2334	broad.mit.edu	37	X	148055022	148055022	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7413-01A-11D-2078-08	TCGA-CV-7413-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be482a19-0de0-4e60-a831-9ebe8545a6f3	741ec714-2c58-4d0c-a373-be69346da938	g.chrX:148055022G>A	uc004fcp.2	+	16	3768	c.3289G>A	c.(3289-3291)GTG>ATG	p.V1097M	AFF2_uc004fcq.2_Missense_Mutation_p.V1087M|AFF2_uc004fcr.2_Missense_Mutation_p.V1058M|AFF2_uc011mxb.1_Missense_Mutation_p.V1062M|AFF2_uc004fcs.2_Missense_Mutation_p.V1062M|AFF2_uc011mxc.1_Missense_Mutation_p.V738M	NM_002025	NP_002016	P51816	AFF2_HUMAN	fragile X mental retardation 2	1097					brain development|mRNA processing|regulation of RNA splicing|RNA splicing	nuclear speck	G-quadruplex RNA binding|protein binding			ovary(3)|pancreas(2)	5	Acute lymphoblastic leukemia(192;6.56e-05)					TGGCAAAGCTGTGAATTATGC	0.408		NA											25	85					0	0	0	0
APOLD1	81575	broad.mit.edu	37	12	12940351	12940353	+	In_Frame_Del	DEL	TCT	TCT	-			TCGA-CV-7413-01A-11D-2078-08	TCGA-CV-7413-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be482a19-0de0-4e60-a831-9ebe8545a6f3	741ec714-2c58-4d0c-a373-be69346da938	g.chr12:12940351_12940353delTCT	uc001rau.3	+	2	689_691	c.605_607delTCT	c.(604-609)GTCTTC>GTC	p.F204del	DDX47_uc001rav.2_Intron|APOLD1_uc001raw.3_In_Frame_Del_p.F173del	NM_001130415	NP_001123887	Q96LR9	APLD1_HUMAN	apolipoprotein L domain containing 1 isoform 1	204	Helical; (Potential).				angiogenesis|cell differentiation|lipid transport|lipoprotein metabolic process	extracellular region|integral to membrane|plasma membrane	lipid binding			ovary(1)	1		Prostate(47;0.0632)		BRCA - Breast invasive adenocarcinoma(232;0.0338)|GBM - Glioblastoma multiforme(207;0.149)		TACTTCATCGTCTTCTTTGGCTC	0.616		NA											45	129	---	---	---	---	NA	NA	NA	NA
MORC4	79710	broad.mit.edu	37	X	106228467	106228468	+	Frame_Shift_Ins	INS	-	-	T			TCGA-CV-7413-01A-11D-2078-08	TCGA-CV-7413-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be482a19-0de0-4e60-a831-9ebe8545a6f3	741ec714-2c58-4d0c-a373-be69346da938	g.chrX:106228467_106228468insT	uc004emu.3	-	5	775_776	c.532_533insA	c.(532-534)ATGfs	p.M178fs	MORC4_uc004emp.3_Intron|MORC4_uc004emv.3_Frame_Shift_Ins_p.M178fs|MORC4_uc004emw.3_Intron	NM_024657	NP_078933	Q8TE76	MORC4_HUMAN	zinc finger, CW type with coiled-coil domain 2	178							ATP binding|zinc ion binding			ovary(1)	1						GGTAATAATCATTTTTTGTAAA	0.361		NA											15	54	---	---	---	---	NA	NA	NA	NA