Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	isArtifactMode	oxoGCut
CA6	765	broad.mit.edu	37	1	9034714	9034714	+	Missense_Mutation	SNP	T	T	G			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr1:9034714T>G	uc001apm.2	+	8	902	c.878T>G	c.(877-879)CTA>CGA	p.L293R	CA6_uc009vmn.2_Missense_Mutation_p.L233R	NM_001215	NP_001206	P23280	CAH6_HUMAN	carbonic anhydrase VI precursor	293					one-carbon metabolic process	extracellular region	carbonate dehydratase activity|zinc ion binding			ovary(2)	2	Ovarian(185;0.112)|all_lung(157;0.143)	all_epithelial(116;1.02e-19)|all_lung(118;3.6e-06)|Lung NSC(185;7.94e-06)|Renal(390;0.000147)|Breast(348;0.00123)|Colorectal(325;0.00205)|Hepatocellular(190;0.00825)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.9e-07)|COAD - Colon adenocarcinoma(227;8.28e-05)|Kidney(185;0.000268)|KIRC - Kidney renal clear cell carcinoma(229;0.000971)|STAD - Stomach adenocarcinoma(132;0.00184)|BRCA - Breast invasive adenocarcinoma(304;0.00192)|READ - Rectum adenocarcinoma(331;0.0649)		CAGTTTTACCTACATAAGATT	0.383		NA											8	10					0	0	0	0
SLC2A5	6518	broad.mit.edu	37	1	9097693	9097693	+	Silent	SNP	C	C	T			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr1:9097693C>T	uc001apo.2	-	12	1750	c.1458G>A	c.(1456-1458)CCG>CCA	p.P486P	SLC2A5_uc010nzy.1_Silent_p.P427P|SLC2A5_uc010nzz.1_Silent_p.P371P|SLC2A5_uc010oaa.1_Silent_p.P442P|SLC2A5_uc010oab.1_Silent_p.P486P	NM_003039	NP_003030	P22732	GTR5_HUMAN	solute carrier family 2 (facilitated	486	Cytoplasmic (Potential).				carbohydrate metabolic process	integral to membrane|plasma membrane	fructose transmembrane transporter activity|glucose transmembrane transporter activity			pancreas(2)|ovary(1)	3	Ovarian(185;0.112)|all_lung(157;0.185)	all_epithelial(116;1.34e-15)|all_lung(118;9.46e-05)|Lung NSC(185;0.000172)|Renal(390;0.000469)|Colorectal(325;0.0062)|Breast(348;0.00715)|Hepatocellular(190;0.0228)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.104)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;7.78e-07)|COAD - Colon adenocarcinoma(227;8.83e-05)|Kidney(185;0.000286)|KIRC - Kidney renal clear cell carcinoma(229;0.00103)|STAD - Stomach adenocarcinoma(132;0.0019)|BRCA - Breast invasive adenocarcinoma(304;0.00199)|READ - Rectum adenocarcinoma(331;0.0649)		CCTCCTTTTCCGGGTACACTT	0.507		NA											49	75					0	0	0	0
CLSTN1	22883	broad.mit.edu	37	1	9794124	9794124	+	Silent	SNP	C	C	G			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr1:9794124C>G	uc001aqh.2	-	15	2946	c.2187G>C	c.(2185-2187)CTG>CTC	p.L729L	CLSTN1_uc001aqi.2_Silent_p.L719L|CLSTN1_uc010oag.1_Silent_p.L710L|CLSTN1_uc001aqf.2_5'Flank	NM_001009566	NP_001009566	O94985	CSTN1_HUMAN	calsyntenin 1 isoform 1	729	Extracellular (Potential).				homophilic cell adhesion	cell junction|cell projection|endoplasmic reticulum membrane|Golgi membrane|integral to membrane|nucleus|postsynaptic membrane	calcium ion binding			skin(1)	1	all_lung(157;0.222)	all_lung(284;4.03e-05)|Lung NSC(185;6.93e-05)|Renal(390;0.000147)|Colorectal(325;0.00205)|Breast(348;0.00314)|Hepatocellular(190;0.00825)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0234)|Colorectal(212;8.36e-08)|COAD - Colon adenocarcinoma(227;1.93e-05)|Kidney(185;0.000342)|BRCA - Breast invasive adenocarcinoma(304;0.000949)|KIRC - Kidney renal clear cell carcinoma(229;0.00122)|STAD - Stomach adenocarcinoma(132;0.00644)|READ - Rectum adenocarcinoma(331;0.0419)		GCTCGTGGTTCAGCTCCTCTC	0.572		NA											18	30					0	0	0	0
CROCC	9696	broad.mit.edu	37	1	17266512	17266512	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr1:17266512G>A	uc001azt.2	+	13	1801	c.1732G>A	c.(1732-1734)GAC>AAC	p.D578N	CROCC_uc009voy.1_Missense_Mutation_p.D281N|CROCC_uc009voz.1_Missense_Mutation_p.D341N|CROCC_uc001azu.2_5'UTR	NM_014675	NP_055490	Q5TZA2	CROCC_HUMAN	ciliary rootlet coiled-coil	578	Potential.				cell cycle|cell projection organization|centrosome organization|protein localization	actin cytoskeleton|centriole|ciliary rootlet|plasma membrane	kinesin binding|structural molecule activity			ovary(2)|breast(2)|central_nervous_system(1)	5		Colorectal(325;3.46e-05)|Breast(348;0.000162)|Lung NSC(340;0.000174)|all_lung(284;0.000234)|Renal(390;0.000518)|Ovarian(437;0.00669)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.63e-06)|COAD - Colon adenocarcinoma(227;1.07e-05)|Kidney(64;0.000163)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.181)		GGACAAGACCGACGGCGCCAT	0.706		NA											6	33					0	0	0	0
YRDC	79693	broad.mit.edu	37	1	38272639	38272639	+	Missense_Mutation	SNP	T	T	C			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr1:38272639T>C	uc001cca.1	-	3	527	c.514A>G	c.(514-516)ATT>GTT	p.I172V	C1orf122_uc001ccb.1_5'Flank	NM_024640	NP_078916	Q86U90	YRDC_HUMAN	ischemia/reperfusion inducible protein	172	YrdC-like.				negative regulation of transport	membrane|mitochondrion					0	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0255)				GGAATCCGAATGCCTACAAGC	0.498		NA											17	20					0	0	0	0
ELOVL1	64834	broad.mit.edu	37	1	43830081	43830081	+	Missense_Mutation	SNP	T	T	C			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr1:43830081T>C	uc001ciz.2	-	8	775	c.532A>G	c.(532-534)ATG>GTG	p.M178V	ELOVL1_uc001cja.2_Missense_Mutation_p.M178V|ELOVL1_uc001cjb.2_Missense_Mutation_p.M178V|ELOVL1_uc001cjc.2_RNA|ELOVL1_uc010okh.1_Missense_Mutation_p.M151V	NM_022821	NP_073732	Q9BW60	ELOV1_HUMAN	elongation of very long chain fatty acids-like	178	Helical; (Potential).				fatty acid elongation, monounsaturated fatty acid|fatty acid elongation, saturated fatty acid|long-chain fatty-acyl-CoA biosynthetic process|sphingolipid biosynthetic process|triglyceride biosynthetic process|very long-chain fatty acid biosynthetic process	integral to endoplasmic reticulum membrane	fatty acid elongase activity|protein binding				0	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0333)				TACAGGTACATTATGACATGC	0.522		NA											66	105					0	0	0	0
CYP4A11	1579	broad.mit.edu	37	1	47403778	47403778	+	Missense_Mutation	SNP	T	T	G			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr1:47403778T>G	uc001cqp.3	-	2	278	c.227A>C	c.(226-228)CAG>CCG	p.Q76P	CYP4A11_uc001cqq.2_Missense_Mutation_p.Q76P|CYP4A11_uc010omm.1_RNA	NM_000778	NP_000769	Q02928	CP4AB_HUMAN	cytochrome P450, family 4, subfamily A,	76					long-chain fatty acid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	alkane 1-monooxygenase activity|electron carrier activity|heme binding|oxygen binding			ovary(2)|skin(2)	4					NADH(DB00157)	CACCCATTTCTGAATCCGTTG	0.488		NA											26	53					0	0	0	0
ZFYVE9	9372	broad.mit.edu	37	1	52759159	52759159	+	Silent	SNP	C	C	T			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr1:52759159C>T	uc001cto.2	+	11	3232	c.3060C>T	c.(3058-3060)TTC>TTT	p.F1020F	ZFYVE9_uc001ctp.2_Silent_p.F961F	NM_004799	NP_004790	O95405	ZFYV9_HUMAN	zinc finger, FYVE domain containing 9 isoform 3	1020					endocytosis|SMAD protein complex assembly|SMAD protein import into nucleus|transforming growth factor beta receptor signaling pathway	early endosome membrane	metal ion binding|protein binding|receptor activity|serine-type peptidase activity			ovary(2)|lung(2)|central_nervous_system(2)|skin(2)	8						ATTCCTTCTTCAGTCAAAGTT	0.348		NA											15	25					0	0	0	0
COL11A1	1301	broad.mit.edu	37	1	103427750	103427750	+	Missense_Mutation	SNP	T	T	A			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr1:103427750T>A	uc001dul.2	-	40	3414	c.3096A>T	c.(3094-3096)AGA>AGT	p.R1032S	COL11A1_uc001duk.2_Missense_Mutation_p.R228S|COL11A1_uc001dum.2_Missense_Mutation_p.R1044S|COL11A1_uc001dun.2_Missense_Mutation_p.R993S|COL11A1_uc009weh.2_Missense_Mutation_p.R916S	NM_001854	NP_001845	P12107	COBA1_HUMAN	alpha 1 type XI collagen isoform A	1032	Triple-helical region.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			ovary(6)|breast(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	12		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		CAGGAAGACCTCTTTCCCCTG	0.388		NA											26	7					0	0	0	0
NBPF10	100132406	broad.mit.edu	37	1	145302676	145302676	+	Missense_Mutation	SNP	G	G	T			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr1:145302676G>T	uc001end.3	+	8	1149	c.1114G>T	c.(1114-1116)GCT>TCT	p.A372S	NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|NBPF10_uc001emp.3_Intron|NBPF10_uc010oyi.1_5'UTR|NBPF10_uc001emq.1_Missense_Mutation_p.A101S	NM_001039703	NP_001034792	A6NDV3	A6NDV3_HUMAN	hypothetical protein LOC100132406	372											0	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		CCTGGTTCACGCTCAGGAACG	0.483		NA											3	36					0.004672	0.00475577	1	0
FCRL3	115352	broad.mit.edu	37	1	157666065	157666065	+	Silent	SNP	C	C	G			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr1:157666065C>G	uc001frb.2	-	7	1189	c.897G>C	c.(895-897)CTG>CTC	p.L299L	FCRL3_uc001fqx.3_RNA|FCRL3_uc001fqy.3_RNA|FCRL3_uc001fqz.3_Silent_p.L299L|FCRL3_uc009wsn.2_RNA|FCRL3_uc009wso.2_RNA|FCRL3_uc001fra.2_Silent_p.L25L|FCRL3_uc001frc.1_Silent_p.L299L	NM_052939	NP_443171	Q96P31	FCRL3_HUMAN	Fc receptor-like 3 precursor	299	Ig-like C2-type 4.|Extracellular (Potential).					integral to membrane|plasma membrane	receptor activity			ovary(3)|breast(1)	4	all_hematologic(112;0.0378)					CTCCTTCAATCAGCTGCCCTC	0.517		NA											7	95					0	0	0	0
ARHGAP30	257106	broad.mit.edu	37	1	161021182	161021182	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr1:161021182C>G	uc001fxl.2	-	10	1688	c.1342G>C	c.(1342-1344)GAG>CAG	p.E448Q	ARHGAP30_uc001fxk.2_Missense_Mutation_p.E448Q|ARHGAP30_uc001fxm.2_Missense_Mutation_p.E294Q|ARHGAP30_uc009wtx.2_Missense_Mutation_p.E121Q|ARHGAP30_uc001fxn.1_Missense_Mutation_p.E294Q	NM_001025598	NP_001020769	Q7Z6I6	RHG30_HUMAN	Rho GTPase activating protein 30 isoform 1	448					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			ovary(2)|upper_aerodigestive_tract(1)	3	all_cancers(52;8.05e-20)|Breast(13;0.00188)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00122)			GCAGGGCACTCAAGGCCACGG	0.433		NA											6	49					0	0	0	0
TOR1AIP2	163590	broad.mit.edu	37	1	179815318	179815318	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr1:179815318G>C	uc001gnk.2	-	6	1689	c.1301C>G	c.(1300-1302)TCC>TGC	p.S434C	TOR1AIP2_uc001gnl.2_Missense_Mutation_p.S434C	NM_145034	NP_659471	Q8NFQ8	TOIP2_HUMAN	torsin A interacting protein 2	434						endoplasmic reticulum membrane|integral to membrane	protein binding			ovary(1)	1						GTGGTTGAAGGAGGTGGGAGT	0.502		NA											5	61					0	0	0	0
DHX9	1660	broad.mit.edu	37	1	182845596	182845596	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr1:182845596C>G	uc001gpr.2	+	18	2207	c.2044C>G	c.(2044-2046)CAG>GAG	p.Q682E	DHX9_uc001gps.2_Missense_Mutation_p.Q468E|DHX9_uc001gpt.2_5'Flank	NM_001357	NP_001348	Q08211	DHX9_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 9	682	Helicase C-terminal.				CRD-mediated mRNA stabilization|nuclear mRNA splicing, via spliceosome	centrosome|CRD-mediated mRNA stability complex|nucleolus|nucleoplasm|ribonucleoprotein complex	ATP binding|ATP-dependent DNA helicase activity|ATP-dependent RNA helicase activity|DNA binding|double-stranded RNA binding|protein binding			ovary(2)	2						CCATCGGTATCAGATTCTACC	0.383		NA											6	56					0	0	0	0
CDK18	5129	broad.mit.edu	37	1	205499409	205499409	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr1:205499409C>T	uc001hcr.2	+	14	1553	c.1334C>T	c.(1333-1335)TCA>TTA	p.S445L	CDK18_uc001hcp.2_Missense_Mutation_p.S415L|CDK18_uc001hcq.2_Missense_Mutation_p.S415L|CDK18_uc010prj.1_Missense_Mutation_p.S326L|CDK18_uc001hcs.2_Missense_Mutation_p.S326L|CDK18_uc009xbm.1_3'UTR|CDK18_uc001hct.2_RNA	NM_212503	NP_997668	Q07002	CDK18_HUMAN	PCTAIRE protein kinase 3 isoform a	413	Protein kinase.						ATP binding|cyclin-dependent protein kinase activity|protein binding|signal transducer activity			stomach(2)	2						AGTCGCATGTCAGCAGAGGCT	0.622		NA											5	70					0	0	0	0
SLC26A9	115019	broad.mit.edu	37	1	205892256	205892256	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr1:205892256C>T	uc001hdq.2	-	16	1841	c.1727G>A	c.(1726-1728)AGA>AAA	p.R576K	SLC26A9_uc001hdo.2_Missense_Mutation_p.R244K|SLC26A9_uc001hdp.2_Missense_Mutation_p.R576K	NM_052934	NP_443166	Q7LBE3	S26A9_HUMAN	solute carrier family 26, member 9 isoform a	576	STAS.					integral to membrane	chloride channel activity|secondary active sulfate transmembrane transporter activity			ovary(1)|skin(1)	2	Breast(84;0.201)		BRCA - Breast invasive adenocarcinoma(75;0.0458)			GGGCCTCATTCTCCGCTTCTC	0.517		NA											28	78					0	0	0	0
CR1	1378	broad.mit.edu	37	1	207787831	207787831	+	Nonsense_Mutation	SNP	G	G	T			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr1:207787831G>T	uc001hfy.2	+	32	5448	c.5308G>T	c.(5308-5310)GAA>TAA	p.E1770*	CR1_uc001hfx.2_Nonsense_Mutation_p.E2220*	NM_000573	NP_000564	P17927	CR1_HUMAN	complement receptor 1 isoform F precursor	1770	Extracellular (Potential).|Sushi 27.				complement activation, classical pathway|innate immune response	integral to plasma membrane	complement receptor activity			ovary(3)	3						TCCAGTGTGTGAACGTGAGTA	0.408		NA											5	45					8.13e-05	8.38e-05	1	0
CAPN2	824	broad.mit.edu	37	1	223958200	223958200	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr1:223958200G>A	uc001hob.3	+	18	2100	c.1876G>A	c.(1876-1878)GAA>AAA	p.E626K	CAPN2_uc010puy.1_Missense_Mutation_p.E548K|CAPN2_uc001hoc.2_Missense_Mutation_p.E207K	NM_001748	NP_001739	P17655	CAN2_HUMAN	calpain 2 isoform 1	626	Domain IV.|EF-hand 2.|2.				proteolysis	cytoplasm|plasma membrane				lung(3)|breast(1)|skin(1)	5				GBM - Glioblastoma multiforme(131;0.109)		GAATTCCTATGAAATGCGGAA	0.393		NA											4	37					0	0	0	0
EXOC8	149371	broad.mit.edu	37	1	231473420	231473420	+	Silent	SNP	C	C	T			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr1:231473420C>T	uc001huq.2	-	1	159	c.72G>A	c.(70-72)GCG>GCA	p.A24A	C1orf124_uc001hur.2_5'Flank|C1orf124_uc001hus.2_5'Flank|C1orf124_uc001hut.2_5'Flank	NM_175876	NP_787072	Q8IYI6	EXOC8_HUMAN	exocyst complex 84-kDa subunit	24					exocytosis|protein transport	growth cone|nucleus	protein binding			skin(1)	1	Breast(184;0.0871)	all_cancers(173;0.151)|Prostate(94;0.183)				CGTACAGCCGCGCCTCAAAAC	0.677		NA											6	50					0	0	0	0
SIPA1L2	57568	broad.mit.edu	37	1	232615429	232615429	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr1:232615429C>T	uc001hvg.2	-	5	2187	c.2029G>A	c.(2029-2031)GAA>AAA	p.E677K		NM_020808	NP_065859	Q9P2F8	SI1L2_HUMAN	signal-induced proliferation-associated 1 like	677	Rap-GAP.				regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			ovary(2)|central_nervous_system(2)|pancreas(1)|skin(1)	6		all_cancers(173;0.00605)|Prostate(94;0.128)|all_epithelial(177;0.186)				AACATGAGTTCGTAGTCTTTG	0.458		NA											5	57					0	0	0	0
GPR137B	7107	broad.mit.edu	37	1	236347168	236347168	+	Missense_Mutation	SNP	G	G	A	rs147708340		TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr1:236347168G>A	uc001hxq.2	+	5	1019	c.928G>A	c.(928-930)GTT>ATT	p.V310I	GPR137B_uc001hxr.1_Missense_Mutation_p.V92I|GPR137B_uc009xge.2_RNA	NM_003272	NP_003263	O60478	G137B_HUMAN	G protein-coupled receptor 137B	310	Helical; (Potential).					integral to plasma membrane|membrane fraction					0	Ovarian(103;0.0634)|Breast(184;0.247)	all_cancers(173;0.197)|Prostate(94;0.219)|Acute lymphoblastic leukemia(190;0.226)	OV - Ovarian serous cystadenocarcinoma(106;0.00162)			CACCTTAGTCGTTTATTTCTT	0.373		NA											18	28					0	0	0	0
OR6F1	343169	broad.mit.edu	37	1	247875239	247875239	+	Silent	SNP	A	A	C			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr1:247875239A>C	uc001idj.1	-	1	819	c.819T>G	c.(817-819)GCT>GCG	p.A273A		NM_001005286	NP_001005286	Q8NGZ6	OR6F1_HUMAN	olfactory receptor, family 6, subfamily F,	273	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.0168)			GGACGTGGACAGCTTTGATCA	0.483		NA											43	55					0	0	0	0
LARP4B	23185	broad.mit.edu	37	10	882344	882344	+	Missense_Mutation	SNP	T	T	A			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr10:882344T>A	uc001ifs.1	-	7	790	c.749A>T	c.(748-750)GAA>GTA	p.E250V		NM_015155	NP_055970	Q92615	LAR4B_HUMAN	La ribonucleoprotein domain family, member 4B	250	RRM.						nucleotide binding|RNA binding			ovary(2)|central_nervous_system(1)	3						ATTACTTACTTCCACGGGGGT	0.363		NA											15	33					0	0	0	0
SLC39A12	221074	broad.mit.edu	37	10	18276458	18276458	+	Silent	SNP	C	C	T			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr10:18276458C>T	uc001ipo.2	+	7	1420	c.1147C>T	c.(1147-1149)CTG>TTG	p.L383L	SLC39A12_uc001ipn.2_Silent_p.L383L|SLC39A12_uc001ipp.2_Silent_p.L383L|SLC39A12_uc010qck.1_Silent_p.L249L	NM_001145195	NP_001138667	Q504Y0	S39AC_HUMAN	solute carrier family 39 (zinc transporter),	383	Helical; (Potential).				zinc ion transport	integral to membrane	metal ion transmembrane transporter activity			ovary(1)|breast(1)	2						GGGCTCCATGCTGGGGACAGC	0.557		NA											22	40					0	0	0	0
PDSS1	23590	broad.mit.edu	37	10	27035305	27035305	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr10:27035305G>A	uc001isv.2	+	12	1197	c.1151G>A	c.(1150-1152)TGC>TAC	p.C384Y	PDSS1_uc001isw.2_3'UTR|PDSS1_uc010qdf.1_Missense_Mutation_p.C122Y	NM_014317	NP_055132	Q5T2R2	DPS1_HUMAN	prenyl diphosphate synthase, subunit 1	384					isoprenoid biosynthetic process|ubiquinone biosynthetic process	mitochondrion	metal ion binding|protein heterodimerization activity				0						CAGCAGTACTGCCATGAAGCA	0.423		NA											6	49					0	0	0	0
ZNF248	57209	broad.mit.edu	37	10	38121209	38121209	+	Silent	SNP	C	C	G			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr10:38121209C>G	uc001izd.1	-	6	1573	c.1074G>C	c.(1072-1074)GGG>GGC	p.G358G	ZNF248_uc009xmc.2_Intron|ZNF248_uc001izb.2_Intron|ZNF248_uc001izc.2_Intron|ZNF248_uc010qeu.1_Silent_p.G358G	NM_021045	NP_066383	Q8NDW4	ZN248_HUMAN	zinc finger protein 248	358					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						TGAAATTACTCCCATTTTCAT	0.403		NA											29	58					0	0	0	0
HNRNPF	3185	broad.mit.edu	37	10	43882509	43882509	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr10:43882509C>T	uc009xmh.1	-	3	1311	c.824G>A	c.(823-825)AGA>AAA	p.R275K	HNRNPF_uc001jar.2_Missense_Mutation_p.R275K|HNRNPF_uc001jas.2_Missense_Mutation_p.R275K|HNRNPF_uc001jat.2_Missense_Mutation_p.R275K|HNRNPF_uc001jav.2_Missense_Mutation_p.R275K|HNRNPF_uc001jau.2_Missense_Mutation_p.R275K|uc010qfa.1_Missense_Mutation_p.S64F	NM_001098208	NP_001091678	P52597	HNRPF_HUMAN	heterogeneous nuclear ribonucleoprotein F	275					regulation of RNA splicing	catalytic step 2 spliceosome|cytoplasm|heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	nucleotide binding|protein binding|single-stranded RNA binding				0						GTCGCCGTATCTGTGGTCATA	0.562		NA											16	11					0	0	0	0
TMEM72	643236	broad.mit.edu	37	10	45430193	45430193	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr10:45430193G>C	uc001jbn.2	+	5	636	c.439G>C	c.(439-441)GAG>CAG	p.E147Q	uc001jbk.1_Intron|uc001jbl.2_Intron|TMEM72_uc009xmm.1_Missense_Mutation_p.E29Q	NM_001123376	NP_001116848	A0PK05	TMM72_HUMAN	transmembrane protein 72	147						integral to membrane					0						GGCCTCCCCAGAGCAGTACAC	0.612		NA											7	83					0	0	0	0
OR13A1	79290	broad.mit.edu	37	10	45799279	45799279	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr10:45799279C>T	uc001jcc.1	-	4	901	c.592G>A	c.(592-594)GAG>AAG	p.E198K	OR13A1_uc001jcd.1_Missense_Mutation_p.E194K	NM_001004297	NP_001004297	Q8NGR1	O13A1_HUMAN	olfactory receptor, family 13, subfamily A,	198	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						GGAGGGACCTCGCAGAAGAAA	0.567		NA											17	23					0	0	0	0
FAM21C	253725	broad.mit.edu	37	10	46250521	46250521	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr10:46250521G>A	uc001jcu.2	+	15	1477	c.1378G>A	c.(1378-1380)GAC>AAC	p.D460N	FAM21C_uc001jcs.1_Missense_Mutation_p.D405N|FAM21C_uc001jct.2_Missense_Mutation_p.D460N|FAM21C_uc010qfi.1_Missense_Mutation_p.D436N|FAM21C_uc010qfj.1_5'UTR|FAM21C_uc010qfk.1_5'Flank	NM_015262	NP_056077	A8K5W5	A8K5W5_HUMAN	hypothetical protein LOC253725	460										ovary(1)	1						tgatgatgatgacgaCTTTTT	0.438		NA											10	13					0	0	0	0
LRRC18	474354	broad.mit.edu	37	10	50122006	50122006	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr10:50122006G>C	uc001jhd.2	-	1	275	c.195C>G	c.(193-195)ATC>ATG	p.I65M	WDFY4_uc001jha.3_Intron|LRRC18_uc001jhe.1_Missense_Mutation_p.I65M	NM_001006939	NP_001006940	Q8N456	LRC18_HUMAN	leucine rich repeat containing 18	65	LRR 2.					cytoplasm				ovary(1)|pancreas(1)	2						TGGAGTCAGGGATCTTCCTGA	0.527		NA											10	22					0	0	0	0
CDH23	64072	broad.mit.edu	37	10	73326583	73326583	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr10:73326583C>T	uc001jrx.3	+	7	891	c.514C>T	c.(514-516)CAG>TAG	p.Q172*	CDH23_uc001jrw.3_Nonsense_Mutation_p.Q172*|CDH23_uc001jrv.2_Nonsense_Mutation_p.Q167*|CDH23_uc009xql.2_Nonsense_Mutation_p.Q217*	NM_022124	NP_071407	Q9H251	CAD23_HUMAN	cadherin-like 23 isoform 1 precursor	172	Cadherin 2.|Extracellular (Potential).				calcium ion transport|calcium-dependent cell-cell adhesion|cytosolic calcium ion homeostasis|equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	cytosol|integral to membrane|plasma membrane|stereocilium	calcium ion binding|protein binding			central_nervous_system(5)|large_intestine(4)|ovary(2)	11						CTACTCCTTCCAGCCCCCCTC	0.612		NA											3	42					0	0	0	0
ATAD1	84896	broad.mit.edu	37	10	89536107	89536107	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr10:89536107C>T	uc001key.1	-	5	944	c.661G>A	c.(661-663)GAT>AAT	p.D221N	ATAD1_uc010qmr.1_Missense_Mutation_p.D163N|ATAD1_uc009xth.1_RNA|ATAD1_uc001kez.1_Missense_Mutation_p.D221N	NM_032810	NP_116199	Q8NBU5	ATAD1_HUMAN	ATPase family, AAA domain containing 1	221						peroxisome	ATP binding|nucleoside-triphosphatase activity			large_intestine(1)|ovary(1)	2		all_cancers(4;6.78e-12)|Prostate(4;3.56e-12)|all_epithelial(4;5.58e-09)|Melanoma(5;0.0273)|Breast(4;0.0424)|all_hematologic(4;0.0846)|Colorectal(252;0.207)|Glioma(4;0.217)|all_neural(4;0.224)		UCEC - Uterine corpus endometrioid carcinoma (6;0.00131)|GBM - Glioblastoma multiforme(1;1.1e-32)|Lung(2;1.4e-05)|LUSC - Lung squamous cell carcinoma(2;2.69e-05)|Colorectal(12;7.09e-05)|COAD - Colon adenocarcinoma(12;0.000261)|STAD - Stomach adenocarcinoma(243;0.235)		TCCAATCCATCCCAGAGACTC	0.403		NA											41	31					0	0	0	0
DNTT	1791	broad.mit.edu	37	10	98064368	98064368	+	Silent	SNP	C	C	T			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr10:98064368C>T	uc001kmf.2	+	1	284	c.114C>T	c.(112-114)TTC>TTT	p.F38F	DNTT_uc001kmg.2_Silent_p.F38F	NM_004088	NP_004079	P04053	TDT_HUMAN	terminal deoxynucleotidyltransferase isoform 1	38	BRCT.				DNA modification	nucleus	DNA binding|DNA nucleotidylexotransferase activity|DNA-directed DNA polymerase activity|metal ion binding			ovary(1)	1		Colorectal(252;0.0815)|all_hematologic(284;0.224)		Epithelial(162;7.97e-08)|all cancers(201;1.89e-06)		TGGTCGTCTTCATTTTGGAGA	0.542		NA											13	12					0	0	0	0
SMC3	9126	broad.mit.edu	37	10	112360248	112360248	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr10:112360248C>G	uc001kze.2	+	22	2605	c.2479C>G	c.(2479-2481)CGA>GGA	p.R827G		NM_005445	NP_005436	Q9UQE7	SMC3_HUMAN	structural maintenance of chromosomes 3	827	Potential.				cell division|DNA mediated transformation|DNA repair|meiosis|mitotic metaphase/anaphase transition|mitotic prometaphase|mitotic spindle organization|negative regulation of DNA endoreduplication|signal transduction|sister chromatid cohesion	basement membrane|chromatin|chromosome, centromeric region|cytoplasm|meiotic cohesin complex|nuclear matrix|nucleoplasm|spindle pole	ATP binding|dynein binding|microtubule motor activity|protein heterodimerization activity			ovary(1)|central_nervous_system(1)|skin(1)	3		Breast(234;0.0848)|Lung NSC(174;0.238)		Epithelial(162;0.00206)|all cancers(201;0.0227)|BRCA - Breast invasive adenocarcinoma(275;0.127)		TATTATTACTCGAGTAGAGAC	0.328		NA											4	86					0	0	0	0
DOCK1	1793	broad.mit.edu	37	10	129224216	129224216	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr10:129224216G>C	uc001ljt.2	+	47	4856	c.4792G>C	c.(4792-4794)GAG>CAG	p.E1598Q	DOCK1_uc010qun.1_Missense_Mutation_p.E1619Q|DOCK1_uc009yaq.2_Missense_Mutation_p.E593Q	NM_001380	NP_001371	Q14185	DOCK1_HUMAN	dedicator of cytokinesis 1	1598	DHR-2.				apoptosis|axon guidance|blood coagulation|integrin-mediated signaling pathway|phagocytosis, engulfment|small GTPase mediated signal transduction	cytosol|membrane	GTP binding|GTPase activator activity|GTPase binding|guanyl-nucleotide exchange factor activity|SH3 domain binding			central_nervous_system(4)|ovary(2)|lung(1)|breast(1)|kidney(1)	9		all_epithelial(44;2.3e-07)|all_lung(145;0.00466)|Lung NSC(174;0.00685)|Colorectal(57;0.0107)|Renal(717;0.0113)|Breast(234;0.0492)|all_neural(114;0.108)|all_hematologic(284;0.14)		BRCA - Breast invasive adenocarcinoma(275;0.0221)|Colorectal(40;0.115)		CGAGAGGATGGAGGCCTGTTT	0.507		NA											27	93					0	0	0	0
CYP2E1	1571	broad.mit.edu	37	10	135346344	135346344	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr10:135346344C>G	uc001lnj.1	+	5	830	c.797C>G	c.(796-798)ACC>AGC	p.T266S	CYP2E1_uc001lnk.1_Missense_Mutation_p.T129S|CYP2E1_uc009ybl.1_Missense_Mutation_p.T67S|CYP2E1_uc009ybm.1_5'UTR|CYP2E1_uc001lnl.1_Missense_Mutation_p.T67S	NM_000773	NP_000764	P05181	CP2E1_HUMAN	cytochrome P450, family 2, subfamily E,	266					drug metabolic process|heterocycle metabolic process|monoterpenoid metabolic process|steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	electron carrier activity|enzyme binding|heme binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen|oxygen binding			central_nervous_system(3)	3		all_cancers(35;1.14e-09)|all_epithelial(44;5.79e-08)|Lung NSC(174;0.00263)|all_lung(145;0.0039)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.172)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;1.12e-06)|all cancers(32;1.43e-06)|Epithelial(32;1.71e-06)	Acetaminophen(DB00316)|Chlorzoxazone(DB00356)|Cinnarizine(DB00568)|Clofibrate(DB00636)|Dacarbazine(DB00851)|Dapsone(DB00250)|Enflurane(DB00228)|Eszopiclone(DB00402)|Ethanol(DB00898)|Ethosuximide(DB00593)|Fomepizole(DB01213)|Glutathione(DB00143)|Halothane(DB01159)|Hexobarbital(DB01355)|Isoflurane(DB00753)|Isoniazid(DB00951)|Menadione(DB00170)|Mephenytoin(DB00532)|Methoxyflurane(DB01028)|Midazolam(DB00683)|Mitoxantrone(DB01204)|Nicotine(DB00184)|Nifedipine(DB01115)|Nitrofurantoin(DB00698)|Orphenadrine(DB01173)|Phenelzine(DB00780)|Quinidine(DB00908)|S-Adenosylmethionine(DB00118)|Sevoflurane(DB01236)|Theophylline(DB00277)|Tolbutamide(DB01124)	CGGGACCTCACCGACTGCCTG	0.512		NA							Naso-/Oropharyngeal/Laryngeal_Cancer_Familial_Clustering_of				18	24					0	0	0	0
SYCE1	93426	broad.mit.edu	37	10	135370596	135370596	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr10:135370596C>G	uc001lno.2	-	7	544	c.439G>C	c.(439-441)GAG>CAG	p.E147Q	CYP2E1_uc001lnl.1_3'UTR|SYCE1_uc001lnm.2_Missense_Mutation_p.E19Q|SYCE1_uc009ybn.2_Missense_Mutation_p.E147Q|SYCE1_uc001lnn.2_Missense_Mutation_p.E111Q	NM_001143764	NP_001137236	Q8N0S2	SYCE1_HUMAN	synaptonemal complex central element protein 1	147	Potential.				cell division	central element				ovary(1)	1		all_cancers(35;7.01e-07)|all_epithelial(44;1.45e-05)|Lung NSC(174;0.027)|all_lung(145;0.0384)|all_neural(114;0.0726)|Glioma(114;0.172)|Melanoma(40;0.175)		OV - Ovarian serous cystadenocarcinoma(35;1.12e-06)|all cancers(32;1.43e-06)|Epithelial(32;1.71e-06)		TTGTTCTTCTCTTCTTCAATC	0.498		NA											14	290					0	0	0	0
ATHL1	80162	broad.mit.edu	37	11	294725	294725	+	Silent	SNP	C	C	G			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr11:294725C>G	uc010qvu.1	+	14	2305	c.2190C>G	c.(2188-2190)CTC>CTG	p.L730L	ATHL1_uc001lor.3_Silent_p.L482L|ATHL1_uc001lou.3_Silent_p.L305L|ATHL1_uc001lov.3_Silent_p.L191L	NM_025092	NP_079368	Q32M88	ATHL1_HUMAN	ATH1, acid trehalase-like 1	730					carbohydrate metabolic process		hydrolase activity, acting on glycosyl bonds			liver(1)|central_nervous_system(1)|skin(1)	3		all_cancers(49;1.12e-06)|all_epithelial(84;0.000375)|Breast(177;0.00122)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;5.38e-28)|Epithelial(43;3.25e-27)|OV - Ovarian serous cystadenocarcinoma(40;1.11e-20)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0327)|LUSC - Lung squamous cell carcinoma(625;0.122)		CCGAGTCACTCACTGTGGACC	0.627		NA											11	178					0	0	0	0
SLC25A22	79751	broad.mit.edu	37	11	794488	794488	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr11:794488G>A	uc001lri.2	-	4	514	c.172C>T	c.(172-174)CGC>TGC	p.R58C	SLC25A22_uc009yci.2_Missense_Mutation_p.R58C|SLC25A22_uc001lrj.2_Missense_Mutation_p.R58C|SLC25A22_uc009ycj.2_Missense_Mutation_p.R58C	NM_024698	NP_078974	Q9H936	GHC1_HUMAN	mitochondrial glutamate carrier 1	58	Solcar 1.					integral to membrane|mitochondrial inner membrane|nucleus	L-glutamate transmembrane transporter activity|protein binding|symporter activity				0		all_cancers(49;4.75e-06)|all_epithelial(84;0.00204)|Breast(177;0.00234)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;6.27e-26)|Epithelial(43;4.84e-25)|OV - Ovarian serous cystadenocarcinoma(40;2.72e-19)|BRCA - Breast invasive adenocarcinoma(625;4.23e-05)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)	L-Glutamic Acid(DB00142)	CCCTCGGAGCGGACGGTCTTG	0.692		NA											4	11					0	0	0	0
SYT8	90019	broad.mit.edu	37	11	1858629	1858629	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr11:1858629C>G	uc001lue.1	+	9	1302	c.1174C>G	c.(1174-1176)CTT>GTT	p.L392V	SYT8_uc001lud.2_Missense_Mutation_p.L392V|SYT8_uc001luf.1_Missense_Mutation_p.L378V|TNNI2_uc010qxc.1_5'Flank|TNNI2_uc010qxd.1_5'Flank|TNNI2_uc010qxe.1_5'Flank	NM_138567	NP_612634	Q8NBV8	SYT8_HUMAN	synaptotagmin VIII	392	Cytoplasmic (Potential).					acrosomal vesicle|integral to membrane|plasma membrane|synaptic vesicle	transporter activity			ovary(1)	1		all_epithelial(84;0.000138)|Breast(177;0.000962)|Ovarian(85;0.0014)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00136)|Lung(200;0.0681)|LUSC - Lung squamous cell carcinoma(625;0.082)		GCAGCCCCGCCTTCGCCTGCG	0.726		NA											9	7					0	0	0	0
SYT9	143425	broad.mit.edu	37	11	7335110	7335110	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr11:7335110C>G	uc001mfe.2	+	3	1219	c.982C>G	c.(982-984)CTA>GTA	p.L328V	SYT9_uc001mfd.2_RNA|SYT9_uc009yfi.2_Intron	NM_175733	NP_783860	Q86SS6	SYT9_HUMAN	synaptotagmin IX	328	Cytoplasmic (Potential).					cell junction|integral to membrane|synaptic vesicle membrane	metal ion binding|transporter activity			ovary(2)|large_intestine(1)	3				Epithelial(150;1.34e-07)|LUSC - Lung squamous cell carcinoma(625;0.0949)		GGATCACTTCCTAGACTTGGC	0.478		NA											46	77					0	0	0	0
NRIP3	56675	broad.mit.edu	37	11	9007292	9007292	+	Silent	SNP	G	G	A			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr11:9007292G>A	uc001mhg.2	-	4	642	c.528C>T	c.(526-528)GGC>GGT	p.G176G	NRIP3_uc010rbu.1_Intron	NM_020645	NP_065696	Q9NQ35	NRIP3_HUMAN	nuclear receptor interacting protein 3	176					proteolysis		aspartic-type endopeptidase activity				0				Epithelial(150;4.77e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0241)		GGCGGAGGGAGCCCAGTGTGA	0.542		NA											34	40					0	0	0	0
CSRP3	8048	broad.mit.edu	37	11	19209824	19209824	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr11:19209824G>A	uc001mpk.2	-	3	257	c.140C>T	c.(139-141)ACG>ATG	p.T47M		NM_003476	NP_003467	P50461	CSRP3_HUMAN	cysteine and glycine-rich protein 3	47	LIM zinc-binding 1.				cell differentiation|skeletal muscle tissue development	cytoskeleton|nucleus	protein binding|zinc ion binding				0						CGCGACTGTCGTGCTGTCAAG	0.557		NA											37	50					0	0	0	0
HARBI1	283254	broad.mit.edu	37	11	46625165	46625165	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr11:46625165G>A	uc001ncy.2	-	3	1213	c.965C>T	c.(964-966)CCG>CTG	p.P322L		NM_173811	NP_776172	Q96MB7	HARB1_HUMAN	harbinger transposase derived 1	322						cytoplasm|nucleus	metal ion binding|nuclease activity				0						CTCCTCTTCCGGGGGCTGTTC	0.512		NA											21	29					0	0	0	0
PTPRJ	5795	broad.mit.edu	37	11	48166647	48166647	+	Nonsense_Mutation	SNP	C	C	G			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr11:48166647C>G	uc001ngp.3	+	14	3237	c.2882C>G	c.(2881-2883)TCA>TGA	p.S961*		NM_002843	NP_002834	Q12913	PTPRJ_HUMAN	protein tyrosine phosphatase, receptor type, J	961	Extracellular (Potential).				contact inhibition|negative regulation of cell growth|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of MAP kinase activity|negative regulation of platelet-derived growth factor receptor signaling pathway|negative regulation of protein kinase B signaling cascade|negative regulation of T cell receptor signaling pathway|negative regulation of vascular permeability|platelet-derived growth factor receptor signaling pathway|positive chemotaxis|positive regulation of focal adhesion assembly|positive regulation of protein kinase B signaling cascade|positive regulation of survival gene product expression	cell surface|cell-cell junction|immunological synapse|integral to plasma membrane|ruffle membrane	beta-catenin binding|delta-catenin binding|gamma-catenin binding|mitogen-activated protein kinase binding|platelet-derived growth factor receptor binding|protein tyrosine phosphatase activity			breast(3)|kidney(3)|ovary(1)|skin(1)	8						AGTCGCTACTCAGATGCTGTT	0.537		NA											9	107					0	0	0	0
OR4S2	219431	broad.mit.edu	37	11	55419207	55419207	+	Silent	SNP	C	C	T			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr11:55419207C>T	uc001nhs.1	+	1	828	c.828C>T	c.(826-828)ATC>ATT	p.I276I		NM_001004059	NP_001004059	Q8NH73	OR4S2_HUMAN	olfactory receptor, family 4, subfamily S,	276	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)	3		all_epithelial(135;0.0748)				ACACCATTATCACTCCCATGT	0.408		NA											6	161					0	0	0	0
AHNAK	79026	broad.mit.edu	37	11	62297223	62297223	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr11:62297223C>G	uc001ntl.2	-	5	4966	c.4666G>C	c.(4666-4668)GAA>CAA	p.E1556Q	AHNAK_uc001ntk.1_Intron	NM_001620	NP_001611	Q09666	AHNK_HUMAN	AHNAK nucleoprotein isoform 1	1556					nervous system development	nucleus	protein binding			ovary(10)|pancreas(4)|skin(4)|upper_aerodigestive_tract(1)	19		Melanoma(852;0.155)				TCTGGAGCTTCAAGATTCACA	0.458		NA											54	109					0	0	0	0
CATSPER1	117144	broad.mit.edu	37	11	65789074	65789074	+	Silent	SNP	C	C	G			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr11:65789074C>G	uc001ogt.2	-	4	1722	c.1584G>C	c.(1582-1584)CTG>CTC	p.L528L		NM_053054	NP_444282	Q8NEC5	CTSR1_HUMAN	sperm-associated cation channel 1	528	Helical; Name=Segment S3; (Potential).				cell differentiation|multicellular organismal development|spermatogenesis	cilium|flagellar membrane|integral to membrane	protein binding			ovary(2)	2						GGGTCTGCATCAGCAAGAAGT	0.632		NA											9	6					0	0	0	0
SUV420H1	51111	broad.mit.edu	37	11	67941319	67941319	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr11:67941319C>G	uc001onm.1	-	6	861	c.605G>C	c.(604-606)AGA>ACA	p.R202T	SUV420H1_uc009yse.1_5'UTR|SUV420H1_uc001onn.1_Missense_Mutation_p.R30T|SUV420H1_uc009ysf.2_5'UTR|SUV420H1_uc001ono.1_Missense_Mutation_p.R202T|SUV420H1_uc001onp.2_Missense_Mutation_p.R202T|SUV420H1_uc010rqa.1_Missense_Mutation_p.R179T|SUV420H1_uc001onq.2_Missense_Mutation_p.R202T	NM_017635	NP_060105	Q4FZB7	SV421_HUMAN	suppressor of variegation 4-20 homolog 1 isoform	202	SET.				regulation of transcription, DNA-dependent|transcription, DNA-dependent		protein binding			ovary(2)|kidney(1)	3						TGATGAGTATCTATTACATGG	0.284		NA											22	34					0	0	0	0
C11orf24	53838	broad.mit.edu	37	11	68029521	68029521	+	Silent	SNP	G	G	A			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr11:68029521G>A	uc001onr.3	-	4	1384	c.942C>T	c.(940-942)ATC>ATT	p.I314I	C11orf24_uc001ons.2_Silent_p.I314I	NM_022338	NP_071733	Q96F05	CK024_HUMAN	hypothetical protein LOC53838 precursor	314	Extracellular (Potential).|Pro-rich.					integral to membrane					0						CCATCTCAGGGATTGGGCTGG	0.667		NA											10	34					0	0	0	0
AQP11	282679	broad.mit.edu	37	11	77301533	77301533	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr11:77301533G>A	uc001oyj.2	+	1	854	c.496G>A	c.(496-498)GCG>ACG	p.A166T	AQP11_uc009yuu.2_Intron	NM_173039	NP_766627	Q8NBQ7	AQP11_HUMAN	aquaporin 11	166	Helical; Name=4; (Potential).					cell surface|integral to membrane	transporter activity				0	all_cancers(14;1.75e-17)|all_epithelial(13;4.7e-20)|Ovarian(111;0.249)		Epithelial(5;4.73e-49)|BRCA - Breast invasive adenocarcinoma(5;1.4e-30)			CTTGCTCAAAGCGGTCATCAC	0.567		NA											30	14					0	0	0	0
CCDC90B	60492	broad.mit.edu	37	11	82985036	82985036	+	Splice_Site	SNP	C	C	G	rs11556842		TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr11:82985036C>G	uc001pae.2	-	5	789	c.427_splice	c.e5-1	p.K143_splice	CCDC90B_uc001pac.2_Splice_Site_p.K42_splice|CCDC90B_uc001pad.2_Splice_Site_p.K42_splice|CCDC90B_uc001paf.2_Splice_Site_p.K134_splice	NM_021825	NP_068597	Q9GZT6	CC90B_HUMAN	coiled-coil domain containing 90B precursor							integral to membrane|mitochondrion|mitochondrion					0		Acute lymphoblastic leukemia(157;0.103)				TTTTCATTTTCTAGGTACAGG	0.284		NA											6	5					0	0	0	0
KIAA1826	84437	broad.mit.edu	37	11	105880399	105880399	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr11:105880399C>G	uc001piy.2	-	3	1074	c.901G>C	c.(901-903)GAG>CAG	p.E301Q	KIAA1826_uc001piz.2_Missense_Mutation_p.E301Q	NM_032424	NP_115800	Q8NCY6	K1826_HUMAN	hypothetical protein LOC84437	301	Potential.					nucleus				breast(1)	1		Melanoma(852;0.000878)|Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0017)|Breast(348;0.0321)		BRCA - Breast invasive adenocarcinoma(274;5.56e-05)|Epithelial(105;0.00432)|all cancers(92;0.0309)		CGTTCTCGCTCAAGTTTTAAC	0.408		NA											6	74					0	0	0	0
OR10G8	219869	broad.mit.edu	37	11	123900988	123900988	+	Missense_Mutation	SNP	T	T	C			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr11:123900988T>C	uc001pzp.1	+	1	659	c.659T>C	c.(658-660)ATC>ACC	p.I220T		NM_001004464	NP_001004464	Q8NGN5	O10G8_HUMAN	olfactory receptor, family 10, subfamily G,	220	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0521)		TATGTGTCCATCGTCTGTTCC	0.542		NA											29	11					0	0	0	0
DCP1B	196513	broad.mit.edu	37	12	2061703	2061703	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr12:2061703G>C	uc001qjx.1	-	7	1483	c.1403C>G	c.(1402-1404)TCT>TGT	p.S468C	DCP1B_uc010sdy.1_Missense_Mutation_p.S366C	NM_152640	NP_689853	Q8IZD4	DCP1B_HUMAN	decapping enzyme Dcp1b	468					exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	cytosol|nucleus	hydrolase activity|protein binding			skin(1)	1			OV - Ovarian serous cystadenocarcinoma(31;0.00193)			TGGCCGGTTAGAGGCATGCAG	0.537		NA											6	67					0	0	0	0
TAS2R46	259292	broad.mit.edu	37	12	11214516	11214516	+	Silent	SNP	C	C	T			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr12:11214516C>T	uc001qzp.1	-	1	378	c.378G>A	c.(376-378)AAG>AAA	p.K126K	PRR4_uc009zhp.2_Intron|PRH1_uc001qzb.3_Intron|PRH1_uc001qzc.2_Intron|PRB4_uc001qzf.1_Intron|PRH1_uc001qzj.2_Intron	NM_176887	NP_795368	P59540	T2R46_HUMAN	taste receptor, type 2, member 46	126	Cytoplasmic (Potential).				sensory perception of taste	cilium membrane|integral to membrane	G-protein coupled receptor activity			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(49;0.0344)	BRCA - Breast invasive adenocarcinoma(232;0.196)		GAACAACACTCTTAACTCTCC	0.348		NA											33	59					0	0	0	0
GRIN2B	2904	broad.mit.edu	37	12	13764753	13764753	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr12:13764753C>T	uc001rbt.2	-	8	1865	c.1686G>A	c.(1684-1686)ATG>ATA	p.M562I		NM_000834	NP_000825	Q13224	NMDE2_HUMAN	N-methyl-D-aspartate receptor subunit 2B	562	Helical; (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	glycine binding|N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			central_nervous_system(4)|ovary(3)|skin(3)|lung(2)	12					Felbamate(DB00949)|Haloperidol(DB00502)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	GCATCACAAACATCATCACCC	0.478		NA											7	67					0	0	0	0
SLC38A2	54407	broad.mit.edu	37	12	46760703	46760703	+	Silent	SNP	C	C	T			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr12:46760703C>T	uc001rpg.2	-	7	947	c.507G>A	c.(505-507)GTG>GTA	p.V169V	SLC38A2_uc010sli.1_5'Flank|SLC38A2_uc001rph.2_Silent_p.V69V	NM_018976	NP_061849	Q96QD8	S38A2_HUMAN	solute carrier family 38, member 2	169	Helical; (Potential).				cellular nitrogen compound metabolic process|glutamate secretion|neurotransmitter secretion|sodium ion transport	integral to membrane|plasma membrane	amino acid transmembrane transporter activity|symporter activity			urinary_tract(1)|skin(1)	2	Lung SC(27;0.192)|Renal(347;0.236)		OV - Ovarian serous cystadenocarcinoma(5;0.0048)|Epithelial(2;0.0374)	GBM - Glioblastoma multiforme(48;0.226)		ACTCATATTTCACTATGAAGA	0.388		NA											14	37					0	0	0	0
GPD1	2819	broad.mit.edu	37	12	50500130	50500130	+	Silent	SNP	C	C	T			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr12:50500130C>T	uc001rvz.2	+	4	453	c.420C>T	c.(418-420)CTC>CTT	p.L140L	GPD1_uc001rwa.2_Silent_p.L117L	NM_005276	NP_005267	P21695	GPDA_HUMAN	glycerol-3-phosphate dehydrogenase 1 (soluble)	140					glycerol-3-phosphate catabolic process|triglyceride biosynthetic process	cytosol|glycerol-3-phosphate dehydrogenase complex	glycerol-3-phosphate dehydrogenase|protein homodimerization activity				0					NADH(DB00157)	GGGAGCGCCTCGGCATCCCCA	0.617		NA											11	10					0	0	0	0
TARBP2	6895	broad.mit.edu	37	12	53899914	53899914	+	Silent	SNP	C	C	T			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr12:53899914C>T	uc001sdo.2	+	9	1571	c.1083C>T	c.(1081-1083)ATC>ATT	p.I361I	TARBP2_uc001sdp.2_Silent_p.I340I|TARBP2_uc001sdq.2_Silent_p.I217I|TARBP2_uc001sdr.2_Silent_p.I217I|TARBP2_uc001sds.2_3'UTR|TARBP2_uc001sdt.2_Silent_p.I340I|TARBP2_uc001sdu.2_Silent_p.I217I|TARBP2_uc001sdv.2_RNA	NM_134323	NP_599150	Q15633	TRBP2_HUMAN	TAR RNA binding protein 2 isoform a	361	Sufficient for interaction with DICER1.|DRBM 3.|Sufficient for interaction with PRKRA.				miRNA loading onto RISC involved in gene silencing by miRNA|negative regulation of defense response to virus by host|negative regulation of protein kinase activity|positive regulation of viral genome replication|pre-miRNA processing|production of siRNA involved in RNA interference|regulation of transcription from RNA polymerase II promoter|regulation of translation|regulation of viral transcription|targeting of mRNA for destruction involved in RNA interference	cytosol|nucleus|perinuclear region of cytoplasm|RNA-induced silencing complex	double-stranded RNA binding|protein homodimerization activity|siRNA binding			central_nervous_system(1)	1						ACCTCAAGATCATGGCAGGCA	0.617		NA											7	21					0	0	0	0
HOXC13	3229	broad.mit.edu	37	12	54332775	54332775	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr12:54332775G>A	uc001sei.2	+	1	200	c.85G>A	c.(85-87)GGC>AGC	p.G29S	HOXC13_uc010sop.1_RNA	NM_017410	NP_059106	P31276	HXC13_HUMAN	homeobox C13	29	Gly-rich.					nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)	1						gagcggcatcggcggcggcgg	0.493		NA	T	NUP98	AML								5	5					0	0	0	0
MYO1A	4640	broad.mit.edu	37	12	57430774	57430774	+	Silent	SNP	C	C	T			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr12:57430774C>T	uc001smw.3	-	20	2400	c.2157G>A	c.(2155-2157)CTG>CTA	p.L719L	MYO1A_uc010sqz.1_Silent_p.L557L|MYO1A_uc009zpd.2_Silent_p.L719L	NM_005379	NP_005370	Q9UBC5	MYO1A_HUMAN	myosin IA	719	IQ 1.				sensory perception of sound|vesicle localization	brush border|cortical actin cytoskeleton|filamentous actin|lateral plasma membrane|microvillus|myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			skin(4)|ovary(2)|urinary_tract(1)	7						TCTTTCGCATCAGTTGGTAGT	0.522		NA											37	64					0	0	0	0
CRADD	8738	broad.mit.edu	37	12	94244018	94244018	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr12:94244018C>T	uc001tda.2	+	3	675	c.571C>T	c.(571-573)CCC>TCC	p.P191S	CRADD_uc010sur.1_Intron|CRADD_uc010sus.1_Intron	NM_003805	NP_003796	P78560	CRADD_HUMAN	CASP2 and RIPK1 domain containing adaptor with	191					apoptosis|cellular response to mechanical stimulus|induction of apoptosis via death domain receptors|signal transduction	intracellular	death domain binding|protease binding|protein binding, bridging			ovary(1)	1						GGAGGTGGACCCCTCGCTGCT	0.632		NA											11	26					0	0	0	0
CCDC63	160762	broad.mit.edu	37	12	111318961	111318961	+	Silent	SNP	G	G	A			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr12:111318961G>A	uc001trv.1	+	7	909	c.714G>A	c.(712-714)CAG>CAA	p.Q238Q	CCDC63_uc009zvt.1_Missense_Mutation_p.E93K|CCDC63_uc010sye.1_Silent_p.Q198Q|CCDC63_uc001trw.1_Silent_p.Q153Q	NM_152591	NP_689804	Q8NA47	CCD63_HUMAN	coiled-coil domain containing 63	238	Potential.									skin(6)|ovary(1)|pancreas(1)	8						AAGACCGCCAGAAGAAGGACA	0.557		NA											3	21					0	0	0	0
KSR2	283455	broad.mit.edu	37	12	117968797	117968797	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr12:117968797G>A	uc001two.2	-	12	1719	c.1664C>T	c.(1663-1665)ACG>ATG	p.T555M		NM_173598	NP_775869	Q6VAB6	KSR2_HUMAN	kinase suppressor of ras 2	584					intracellular signal transduction	cytoplasm|membrane	ATP binding|metal ion binding|protein serine/threonine kinase activity			lung(10)|central_nervous_system(2)|stomach(1)|large_intestine(1)|breast(1)	15	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					CCGGGTCGGCGTCTCCGGCAC	0.562		NA											45	72					0	0	0	0
SRRM4	84530	broad.mit.edu	37	12	119568510	119568510	+	Silent	SNP	G	G	A			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr12:119568510G>A	uc001txa.1	+	8	934	c.642G>A	c.(640-642)GGG>GGA	p.G214G		NM_194286	NP_919262	A7MD48	SRRM4_HUMAN	KIAA1853 protein	214	Ser-rich.				cell differentiation|mRNA processing|nervous system development|regulation of RNA splicing|RNA splicing	nucleus	mRNA binding			ovary(2)	2						CTGAGGAAGGGCAGAAGTCCC	0.652		NA											5	4					0	0	0	0
UBC	7316	broad.mit.edu	37	12	125397967	125397967	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr12:125397967C>G	uc001ugs.3	-	2	799	c.351G>C	c.(349-351)CAG>CAC	p.Q117H	UBC_uc001ugr.2_5'Flank|UBC_uc001ugu.1_Missense_Mutation_p.Q117H|UBC_uc001ugt.2_Missense_Mutation_p.Q117H|UBC_uc001ugv.2_Intron|UBC_uc001ugw.2_5'UTR	NM_021009	NP_066289	P0CG48	UBC_HUMAN	ubiquitin C	117	Ubiquitin-like 2.				activation of MAPK activity|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|anti-apoptosis|apoptosis|cellular membrane organization|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA repair|endosome transport|epidermal growth factor receptor signaling pathway|G1/S transition of mitotic cell cycle|I-kappaB kinase/NF-kappaB cascade|induction of apoptosis by extracellular signals|innate immune response|JNK cascade|M/G1 transition of mitotic cell cycle|mRNA metabolic process|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of type I interferon production|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|S phase of mitotic cell cycle|stress-activated MAPK cascade|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|viral reproduction	cytosol|endocytic vesicle membrane|endosome membrane|nucleoplasm|plasma membrane	protein binding			ovary(2)	2	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;6.17e-05)|Epithelial(86;0.000207)|all cancers(50;0.00308)		AGATCAACCTCTGCTGGTCAG	0.547		NA											60	112					0	0	0	0
USPL1	10208	broad.mit.edu	37	13	31233392	31233392	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr13:31233392G>C	uc001utc.2	+	9	3610	c.3178G>C	c.(3178-3180)GAT>CAT	p.D1060H	USPL1_uc001utd.2_Missense_Mutation_p.D731H|USPL1_uc001ute.1_Missense_Mutation_p.D731H	NM_005800	NP_005791	Q5W0Q7	USPL1_HUMAN	ubiquitin specific peptidase like 1	1060					ubiquitin-dependent protein catabolic process		ubiquitin thiolesterase activity			pancreas(2)|skin(1)	3		Lung SC(185;0.0257)|Breast(139;0.203)		all cancers(112;0.0306)|Epithelial(112;0.131)|OV - Ovarian serous cystadenocarcinoma(117;0.134)		GATGAAGACTGATATTTTCGA	0.378		NA											7	56					0	0	0	0
COG3	83548	broad.mit.edu	37	13	46092895	46092895	+	Splice_Site	SNP	A	A	G			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr13:46092895A>G	uc001vak.2	+	18	2032	c.1931_splice	c.e18-2	p.D644_splice	COG3_uc010tfv.1_Splice_Site_p.D481_splice|COG3_uc010aci.2_Splice_Site_p.D420_splice	NM_031431	NP_113619	Q96JB2	COG3_HUMAN	component of golgi transport complex 3						ER to Golgi vesicle-mediated transport|intra-Golgi vesicle-mediated transport|intracellular protein transport|protein glycosylation|protein localization to organelle|protein stabilization|retrograde vesicle-mediated transport, Golgi to ER	cis-Golgi network|Golgi cisterna membrane|Golgi transport complex	protein binding|protein transporter activity			breast(1)|skin(1)	2		Lung NSC(96;0.000145)|Breast(56;0.000596)|Prostate(109;0.00438)|Hepatocellular(98;0.0207)|Lung SC(185;0.0262)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;0.000124)		TTTGTTTCACAGATGCAGCAT	0.398		NA											6	56					0	0	0	0
LCP1	3936	broad.mit.edu	37	13	46732751	46732751	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr13:46732751C>G	uc001vaz.3	-	4	390	c.264G>C	c.(262-264)AAG>AAC	p.K88N	LCP1_uc001vba.3_Missense_Mutation_p.K88N	NM_002298	NP_002289	P13796	PLSL_HUMAN	L-plastin	88					regulation of intracellular protein transport|T cell activation involved in immune response	cell junction|cytosol|ruffle membrane	calcium ion binding			lung(4)|ovary(3)	7		Lung NSC(96;1.27e-05)|Breast(56;8.04e-05)|Prostate(109;0.00217)|Hepatocellular(98;0.0207)|Lung SC(185;0.0262)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;5.39e-05)		TTCTAAAGGTCTTGGCAACAT	0.398		NA	T	BCL6	NHL 								13	38					0	0	0	0
ARHGEF7	8874	broad.mit.edu	37	13	111919901	111919901	+	Silent	SNP	C	C	G			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr13:111919901C>G	uc001vrs.2	+	10	1270	c.1020C>G	c.(1018-1020)CCC>CCG	p.P340P	ARHGEF7_uc001vrr.2_Silent_p.P319P|ARHGEF7_uc001vrt.2_Silent_p.P290P|ARHGEF7_uc010tjn.1_RNA|ARHGEF7_uc001vru.1_Silent_p.P162P|ARHGEF7_uc001vrv.3_Silent_p.P162P|ARHGEF7_uc001vrw.3_Silent_p.P162P|ARHGEF7_uc001vrx.3_Silent_p.P162P|ARHGEF7_uc010tjo.1_Silent_p.P237P|ARHGEF7_uc010tjp.1_Silent_p.P84P|ARHGEF7_uc010agn.1_Silent_p.P84P	NM_001113511	NP_001106983	Q14155	ARHG7_HUMAN	PAK-interacting exchange factor beta isoform c	340	DH.				apoptosis|epidermal growth factor receptor signaling pathway|induction of apoptosis by extracellular signals|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	protein binding|Rho guanyl-nucleotide exchange factor activity			ovary(2)|skin(2)|pancreas(1)|lung(1)|kidney(1)	7	all_lung(23;3.96e-05)|Lung NSC(43;0.00156)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Medulloblastoma(90;0.163)		BRCA - Breast invasive adenocarcinoma(86;0.188)			CCAGGTTGCCCGAAGCTCAGC	0.453		NA											33	130					0	0	0	0
ATP11A	23250	broad.mit.edu	37	13	113481013	113481013	+	Silent	SNP	C	C	G			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr13:113481013C>G	uc001vsi.3	+	12	1117	c.1029C>G	c.(1027-1029)CTC>CTG	p.L343L	ATP11A_uc001vsj.3_Silent_p.L343L|ATP11A_uc001vsm.1_Silent_p.L219L	NM_015205	NP_056020	P98196	AT11A_HUMAN	ATPase, class VI, type 11A isoform a	343	Extracellular (Potential).				ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			large_intestine(2)|ovary(2)	4	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)	all_lung(25;0.134)|all_epithelial(44;0.141)				TGCAGTTCCTCAAGGCATTCA	0.537		NA											19	89					0	0	0	0
RNASE10	338879	broad.mit.edu	37	14	20978796	20978796	+	Missense_Mutation	SNP	A	A	T			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr14:20978796A>T	uc010tlj.1	+	1	166	c.166A>T	c.(166-168)ACT>TCT	p.T56S	RNASE10_uc001vxp.2_Missense_Mutation_p.T84S	NM_001012975	NP_001012993	Q5GAN6	RNS10_HUMAN	ribonuclease, RNase A family, 10 (non-active)	56						extracellular region	nucleic acid binding|pancreatic ribonuclease activity				0	all_cancers(95;0.00123)		Epithelial(56;1.81e-07)|all cancers(55;1.86e-06)	GBM - Glioblastoma multiforme(265;0.022)|READ - Rectum adenocarcinoma(17;0.191)		AGCTGAGGCCACTGAGGAGGG	0.488		NA											24	33					0	0	0	0
MMP14	4323	broad.mit.edu	37	14	23310776	23310776	+	Missense_Mutation	SNP	C	C	T	rs139231227		TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr14:23310776C>T	uc001whc.2	+	2	419	c.185C>T	c.(184-186)TCA>TTA	p.S62L		NM_004995	NP_004986	P50281	MMP14_HUMAN	matrix metalloproteinase 14 preproprotein	62						extracellular matrix|integral to plasma membrane|melanosome	calcium ion binding|metalloendopeptidase activity|zinc ion binding				0	all_cancers(95;9.47e-05)			GBM - Glioblastoma multiforme(265;0.00551)		CAGTCACTCTCAGCGGCCATC	0.557		NA											3	20					0	0	0	0
FOXG1	2290	broad.mit.edu	37	14	29237831	29237831	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr14:29237831C>T	uc001wqe.2	+	1	1545	c.1346C>T	c.(1345-1347)TCG>TTG	p.S449L		NM_005249	NP_005240	P55316	FOXG1_HUMAN	forkhead box G1	449				ST -> RP (in Ref. 1; CAA52239).|QAPST -> AGPPRP (in Ref. 1; CAA52240 and 2; CAA55038).	axon midline choice point recognition|central nervous system neuron development|dorsal/ventral pattern formation|embryo development ending in birth or egg hatching|hindbrain development|inner ear morphogenesis|negative regulation of neuron differentiation|negative regulation of transcription, DNA-dependent|nonmotile primary cilium assembly|nose development|positive regulation of cell cycle|positive regulation of neuroblast proliferation|positive regulation of transcription from RNA polymerase II promoter|regulation of mitotic cell cycle|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			ovary(2)|lung(2)	4			LUAD - Lung adenocarcinoma(48;0.011)|Lung(238;0.0575)	GBM - Glioblastoma multiforme(265;0.00413)		CAGGCCCCCTCGACCCTGCCC	0.582		NA											22	37					0	0	0	0
ARHGAP5	394	broad.mit.edu	37	14	32560615	32560615	+	Missense_Mutation	SNP	A	A	G			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr14:32560615A>G	uc001wrl.2	+	2	979	c.740A>G	c.(739-741)GAT>GGT	p.D247G	ARHGAP5_uc001wrm.2_Missense_Mutation_p.D247G|ARHGAP5_uc001wrn.2_Missense_Mutation_p.D247G|ARHGAP5_uc001wro.2_Intron|ARHGAP5_uc001wrp.2_Intron	NM_001173	NP_001025226	Q13017	RHG05_HUMAN	Rho GTPase activating protein 5 isoform b	247					cell adhesion|Rho protein signal transduction	cytosol|membrane	GTP binding|GTPase activity|Rho GTPase activator activity|SH2 domain binding			ovary(4)|central_nervous_system(1)	5	Hepatocellular(127;0.0604)|Prostate(35;0.15)|Breast(36;0.186)		LUAD - Lung adenocarcinoma(48;0.00192)|Lung(238;0.00714)|BRCA - Breast invasive adenocarcinoma(188;0.0952)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.00566)		CAAATGTTGGATAAAACTCGT	0.343		NA											55	92					0	0	0	0
AKAP6	9472	broad.mit.edu	37	14	33004796	33004796	+	Missense_Mutation	SNP	A	A	G			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr14:33004796A>G	uc001wrq.2	+	3	531	c.361A>G	c.(361-363)ATC>GTC	p.I121V	AKAP6_uc010aml.2_Missense_Mutation_p.I118V	NM_004274	NP_004265	Q13023	AKAP6_HUMAN	A-kinase anchor protein 6	121					protein targeting	calcium channel complex|nuclear membrane|sarcoplasmic reticulum	protein kinase A binding|receptor binding			breast(6)|ovary(5)|lung(4)|skin(3)|large_intestine(2)|pancreas(1)	21	Breast(36;0.0388)|Prostate(35;0.15)		LUAD - Lung adenocarcinoma(48;0.00107)|Lung(238;0.00677)|STAD - Stomach adenocarcinoma(7;0.116)	GBM - Glioblastoma multiforme(265;0.019)		TGTTGAGCAAATCCATGCCCT	0.473		NA											30	63					0	0	0	0
RALGAPA1	253959	broad.mit.edu	37	14	36103865	36103865	+	Silent	SNP	A	A	G			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr14:36103865A>G	uc001wti.2	-	32	4783	c.4392T>C	c.(4390-4392)TTT>TTC	p.F1464F	RALGAPA1_uc010amp.2_RNA|RALGAPA1_uc001wtj.2_Silent_p.F1464F|RALGAPA1_uc010tpv.1_Silent_p.F1477F|RALGAPA1_uc010tpw.1_Silent_p.F1511F	NM_014990	NP_055805	Q6GYQ0	RGPA1_HUMAN	Ral GTPase activating protein, alpha subunit 1	1464	Minimal domain that binds to TCF3/E12 (By similarity).				activation of Ral GTPase activity	cytosol|mitochondrion|nucleus	protein heterodimerization activity|Ral GTPase activator activity			ovary(3)|breast(1)	4						CCAAATGCATAAAAGGATCAT	0.423		NA											16	35					0	0	0	0
FRMD6	122786	broad.mit.edu	37	14	52156612	52156612	+	Missense_Mutation	SNP	A	A	G			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr14:52156612A>G	uc001wzd.2	+	2	343	c.58A>G	c.(58-60)ATT>GTT	p.I20V	FRMD6_uc001wzb.2_Missense_Mutation_p.I20V|FRMD6_uc001wzc.2_Missense_Mutation_p.I20V	NM_152330	NP_689543	Q96NE9	FRMD6_HUMAN	FERM domain containing 6	20	FERM.					cytoskeleton|mitochondrion|plasma membrane	binding			ovary(1)|breast(1)|central_nervous_system(1)	3	all_epithelial(31;0.0163)|Breast(41;0.089)					CAGTGTGTGCATTTTCCTTCC	0.433		NA											23	21					0	0	0	0
PTGDR	5729	broad.mit.edu	37	14	52741596	52741596	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr14:52741596C>T	uc001wzq.2	+	2	1096	c.994C>T	c.(994-996)CGG>TGG	p.R332W		NM_000953	NP_000944	Q13258	PD2R_HUMAN	prostaglandin D2 receptor	332	Cytoplasmic (Potential).					integral to membrane|plasma membrane	prostaglandin D receptor activity|protein binding			ovary(1)|lung(1)|central_nervous_system(1)|skin(1)	4	Breast(41;0.0639)|all_epithelial(31;0.0887)				Nedocromil(DB00716)	TCCAGTATTTCGGATATTTTT	0.413		NA											11	13					0	0	0	0
RTN1	6252	broad.mit.edu	37	14	60072193	60072193	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr14:60072193G>A	uc001xen.1	-	5	2214	c.2005C>T	c.(2005-2007)CAG>TAG	p.Q669*	RTN1_uc001xem.1_Nonsense_Mutation_p.Q249*|RTN1_uc001xek.1_Nonsense_Mutation_p.Q101*|RTN1_uc001xel.1_RNA|RTN1_uc010apl.1_Nonsense_Mutation_p.Q86*	NM_021136	NP_066959	Q16799	RTN1_HUMAN	reticulon 1 isoform A	669	Reticulon.				neuron differentiation	integral to endoplasmic reticulum membrane	signal transducer activity			ovary(2)|central_nervous_system(2)	4				OV - Ovarian serous cystadenocarcinoma(108;0.0968)		ATCTGCTCCTGAGAAAGGGTG	0.517		NA											13	35					0	0	0	0
ZBTB1	22890	broad.mit.edu	37	14	64988268	64988268	+	Missense_Mutation	SNP	A	A	T			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr14:64988268A>T	uc001xhh.3	+	4	477	c.46A>T	c.(46-48)AAC>TAC	p.N16Y	ZBTB1_uc010aqg.2_Missense_Mutation_p.N16Y|ZBTB1_uc001xhi.2_Missense_Mutation_p.N16Y	NM_001123329	NP_001116801	Q9Y2K1	ZBTB1_HUMAN	zinc finger and BTB domain containing 1 isoform	16					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1		all_lung(585;0.000567)|Myeloproliferative disorder(585;0.0255)|all_neural(303;0.0294)		UCEC - Uterine corpus endometrioid carcinoma (185;0.0182)|all cancers(60;3.78e-43)|OV - Ovarian serous cystadenocarcinoma(108;1.22e-20)|BRCA - Breast invasive adenocarcinoma(234;6.75e-06)|KIRC - Kidney renal clear cell carcinoma(182;0.00269)|STAD - Stomach adenocarcinoma(64;0.012)		GCAGCTAAACAACCAAAGAGA	0.393		NA											26	42					0	0	0	0
RDH11	51109	broad.mit.edu	37	14	68151825	68151825	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr14:68151825G>C	uc001xjv.3	-	6	851	c.761C>G	c.(760-762)TCC>TGC	p.S254C	RDH11_uc001xjw.3_Missense_Mutation_p.S241C|RDH11_uc001xjx.3_Missense_Mutation_p.S184C	NM_016026	NP_057110	Q8TC12	RDH11_HUMAN	retinol dehydrogenase 11	254	Cytoplasmic (Potential).				retinol metabolic process|steroid metabolic process	endoplasmic reticulum membrane|integral to membrane	binding|NADP-retinol dehydrogenase activity|retinol dehydrogenase activity			ovary(1)	1				all cancers(60;0.00047)|OV - Ovarian serous cystadenocarcinoma(108;0.00206)|BRCA - Breast invasive adenocarcinoma(234;0.00924)	Vitamin A(DB00162)	GATGAAAAAGGAGAAAAGCCA	0.493		NA											4	64					0	0	0	0
RDH12	145226	broad.mit.edu	37	14	68196078	68196078	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr14:68196078C>G	uc001xjz.3	+	8	1153	c.829C>G	c.(829-831)CTG>GTG	p.L277V		NM_152443	NP_689656	Q96NR8	RDH12_HUMAN	retinol dehydrogenase 12	277					photoreceptor cell maintenance|response to stimulus|retinol metabolic process	intracellular	binding|retinol dehydrogenase activity			ovary(1)	1				all cancers(60;0.000704)|OV - Ovarian serous cystadenocarcinoma(108;0.00161)|BRCA - Breast invasive adenocarcinoma(234;0.00953)	Vitamin A(DB00162)	CCTGGAGCCCCTGAGTGGCAA	0.642		NA											5	86					0	0	0	0
SIPA1L1	26037	broad.mit.edu	37	14	72138364	72138364	+	Silent	SNP	T	T	C			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr14:72138364T>C	uc001xms.2	+	8	3132	c.2784T>C	c.(2782-2784)AGT>AGC	p.S928S	SIPA1L1_uc001xmt.2_Silent_p.S928S|SIPA1L1_uc001xmu.2_Silent_p.S928S|SIPA1L1_uc001xmv.2_Silent_p.S928S|SIPA1L1_uc010ttm.1_Silent_p.S403S	NM_015556	NP_056371	O43166	SI1L1_HUMAN	signal-induced proliferation-associated 1 like	928					actin cytoskeleton reorganization|activation of Rap GTPase activity|regulation of dendritic spine morphogenesis	cell junction|cytoplasm|dendritic spine|postsynaptic density|postsynaptic membrane|synaptosome	GTPase activator activity			ovary(3)|breast(1)	4				all cancers(60;0.00169)|BRCA - Breast invasive adenocarcinoma(234;0.00912)|OV - Ovarian serous cystadenocarcinoma(108;0.0109)		CAGTGGGTAGTTTTATTAACA	0.398		NA											53	35					0	0	0	0
RGS6	9628	broad.mit.edu	37	14	72939626	72939626	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr14:72939626C>G	uc001xna.3	+	9	1106	c.583C>G	c.(583-585)CAA>GAA	p.Q195E	RGS6_uc010ttn.1_Missense_Mutation_p.Q195E|RGS6_uc001xmx.3_Missense_Mutation_p.Q195E|RGS6_uc010tto.1_RNA|RGS6_uc001xmy.3_Missense_Mutation_p.Q195E|RGS6_uc010ttp.1_Missense_Mutation_p.Q126E|RGS6_uc001xmz.1_Missense_Mutation_p.Q56E|RGS6_uc010arg.2_RNA	NM_004296	NP_004287	P49758	RGS6_HUMAN	regulator of G-protein signalling 6	195					G-protein coupled receptor protein signaling pathway|intracellular signal transduction|negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway	cytoplasm|heterotrimeric G-protein complex	GTPase activator activity|signal transducer activity			upper_aerodigestive_tract(1)|lung(1)|skin(1)	3				all cancers(60;0.00309)|BRCA - Breast invasive adenocarcinoma(234;0.0281)|STAD - Stomach adenocarcinoma(64;0.0302)|OV - Ovarian serous cystadenocarcinoma(108;0.0476)		TTTGGATAGTCAAGAACGAGC	0.363		NA											11	219					0	0	0	0
SPTLC2	9517	broad.mit.edu	37	14	78028787	78028787	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr14:78028787G>C	uc001xub.2	-	6	990	c.802C>G	c.(802-804)CTG>GTG	p.L268V		NM_004863	NP_004854	O15270	SPTC2_HUMAN	serine palmitoyltransferase, long chain base	268						integral to membrane|serine C-palmitoyltransferase complex	pyridoxal phosphate binding|serine C-palmitoyltransferase activity|transferase activity, transferring nitrogenous groups			upper_aerodigestive_tract(1)|ovary(1)	2			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0346)	L-Serine(DB00133)|Pyridoxal Phosphate(DB00114)	CTGGCTCCCAGAACCAGTGAT	0.453		NA											32	42					0	0	0	0
TDP1	55775	broad.mit.edu	37	14	90446954	90446954	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr14:90446954G>C	uc001xxy.2	+	8	1161	c.862G>C	c.(862-864)GAC>CAC	p.D288H	TDP1_uc010atm.2_RNA|TDP1_uc001xxz.2_Missense_Mutation_p.D288H|TDP1_uc010atn.2_Missense_Mutation_p.D288H|TDP1_uc001xya.2_Missense_Mutation_p.D49H|TDP1_uc001xyb.2_RNA|TDP1_uc010ato.2_Missense_Mutation_p.D288H	NM_018319	NP_060789	Q9NUW8	TYDP1_HUMAN	tyrosyl-DNA phosphodiesterase 1	288					cell death|double-strand break repair|single strand break repair	cytoplasm|nucleus	3'-tyrosyl-DNA phosphodiesterase activity|double-stranded DNA binding|exonuclease activity|protein binding|single-stranded DNA binding			ovary(2)	2		all_cancers(154;0.185)		COAD - Colon adenocarcinoma(157;0.23)		CATCCATGCTGACTGGCACCA	0.453		NA						Repair_of_DNA-protein_crosslinks					8	42					0	0	0	0
C14orf102	55051	broad.mit.edu	37	14	90783141	90783141	+	Nonsense_Mutation	SNP	G	G	C			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr14:90783141G>C	uc001xyi.1	-	3	219	c.188C>G	c.(187-189)TCA>TGA	p.S63*	C14orf102_uc001xyj.1_Intron	NM_017970	NP_060440	Q9H7Z3	CN102_HUMAN	hypothetical protein LOC55051 isoform 1	63	Potential.						protein binding			ovary(2)|lung(1)	3		all_cancers(154;0.118)		COAD - Colon adenocarcinoma(157;0.218)		TGAAGACTCTGATTTCAGATG	0.194		NA											11	50					0	0	0	0
PRIMA1	145270	broad.mit.edu	37	14	94245530	94245530	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr14:94245530G>C	uc001ybw.1	-	3	263	c.221C>G	c.(220-222)TCC>TGC	p.S74C	PRIMA1_uc001ybx.1_RNA	NM_178013	NP_821092	Q86XR5	PRIMA_HUMAN	proline rich membrane anchor 1 precursor	74	Extracellular (Potential).				neurotransmitter catabolic process	cell junction|integral to membrane|synapse				large_intestine(1)|skin(1)	2		all_cancers(154;0.127)		Epithelial(152;0.138)|COAD - Colon adenocarcinoma(157;0.229)		ACCTggggcggagaggagtct	0.368		NA											3	7					0	0	0	0
MAGEL2	54551	broad.mit.edu	37	15	23890666	23890666	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr15:23890666G>A	uc001ywj.3	-	1	510	c.415C>T	c.(415-417)CGC>TGC	p.R139C		NM_019066	NP_061939			MAGE-like protein 2												0		all_cancers(20;1.78e-24)|all_epithelial(15;7.75e-22)|Lung NSC(15;2.96e-18)|all_lung(15;2.8e-17)|Breast(32;0.000625)|Colorectal(260;0.14)		all cancers(64;1.84e-06)|Epithelial(43;1.2e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00177)		GGGGCCCTGCGCTCCTTCGAG	0.577		NA											10	15					0	0	0	0
C15orf2	23742	broad.mit.edu	37	15	24923324	24923324	+	Silent	SNP	T	T	A			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr15:24923324T>A	uc001ywo.2	+	1	2784	c.2310T>A	c.(2308-2310)CCT>CCA	p.P770P		NM_018958	NP_061831	Q9NZP6	CO002_HUMAN	hypothetical protein LOC23742	770					cell differentiation|multicellular organismal development|spermatogenesis					ovary(2)|large_intestine(2)|skin(2)|kidney(1)|central_nervous_system(1)	8		all_cancers(20;2.14e-21)|all_epithelial(15;4.77e-19)|Lung NSC(15;1.43e-14)|all_lung(15;9.57e-14)|Breast(32;0.00086)		all cancers(64;3.19e-24)|Epithelial(43;2.67e-17)|GBM - Glioblastoma multiforme(186;7.36e-07)|BRCA - Breast invasive adenocarcinoma(123;0.000273)|Lung(196;0.229)		GAGCCACCCCTCAACCCAAAT	0.562		NA											55	112					0	0	0	0
TP53BP1	7158	broad.mit.edu	37	15	43708450	43708450	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr15:43708450G>C	uc001zrs.2	-	22	4979	c.4831C>G	c.(4831-4833)CTT>GTT	p.L1611V	TP53BP1_uc010udp.1_Missense_Mutation_p.L1611V|TP53BP1_uc001zrq.3_Missense_Mutation_p.L1616V|TP53BP1_uc001zrr.3_Missense_Mutation_p.L1616V|TP53BP1_uc010udq.1_Missense_Mutation_p.L1616V|TP53BP1_uc001zrp.2_Missense_Mutation_p.L28V	NM_005657	NP_005648	Q12888	TP53B_HUMAN	tumor protein p53 binding protein 1 isoform 3	1611					double-strand break repair via homologous recombination|positive regulation of transcription from RNA polymerase II promoter	condensed chromosome kinetochore|cytoplasm|nucleoplasm	p53 binding|RNA polymerase II activating transcription factor binding|RNA polymerase II transcription cofactor activity			ovary(2)|skin(2)|large_intestine(1)|pancreas(1)|kidney(1)	7		all_cancers(109;6.94e-11)|all_epithelial(112;2.69e-09)|Lung NSC(122;7.86e-07)|all_lung(180;7.84e-06)|Melanoma(134;0.0728)		GBM - Glioblastoma multiforme(94;1.59e-06)		GCCTTTGTAAGAGGTGTTACT	0.483		NA						Direct_reversal_of_damage|Other_conserved_DNA_damage_response_genes					5	75					0	0	0	0
SLC27A2	11001	broad.mit.edu	37	15	50494767	50494767	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr15:50494767G>A	uc001zxw.2	+	3	1004	c.772G>A	c.(772-774)GAT>AAT	p.D258N	SLC27A2_uc010bes.2_Intron|SLC27A2_uc001zxx.2_Missense_Mutation_p.D23N	NM_003645	NP_003636	O14975	S27A2_HUMAN	solute carrier family 27 (fatty acid	258	Lumenal (Potential).				bile acid biosynthetic process|fatty acid alpha-oxidation	endoplasmic reticulum membrane|integral to membrane|peroxisomal matrix|peroxisomal membrane	ATP binding|long-chain fatty acid-CoA ligase activity|phytanate-CoA ligase activity|pristanate-CoA ligase activity			ovary(1)|skin(1)	2		all_lung(180;0.00177)		all cancers(107;1.16e-06)|GBM - Glioblastoma multiforme(94;0.000113)		GAAGGCAGATGATGTCATCTA	0.428		NA											7	89					0	0	0	0
TRPM7	54822	broad.mit.edu	37	15	50940979	50940979	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr15:50940979C>G	uc001zyt.3	-	4	490	c.226G>C	c.(226-228)GAA>CAA	p.E76Q	TRPM7_uc010bew.1_Missense_Mutation_p.E76Q	NM_017672	NP_060142	Q96QT4	TRPM7_HUMAN	transient receptor potential cation channel,	76	Cytoplasmic (Potential).				cell death	integral to membrane	ATP binding|calcium channel activity|metal ion binding|protein serine/threonine kinase activity			ovary(4)|stomach(3)|breast(1)|central_nervous_system(1)|skin(1)	10				all cancers(107;0.000819)|GBM - Glioblastoma multiforme(94;0.0045)		GACCATTCTTCTATTGCCTGA	0.413		NA											36	95					0	0	0	0
MYO5C	55930	broad.mit.edu	37	15	52515861	52515861	+	Silent	SNP	C	C	T			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr15:52515861C>T	uc010bff.2	-	29	3644	c.3507G>A	c.(3505-3507)TTG>TTA	p.L1169L	MYO5C_uc010uga.1_RNA	NM_018728	NP_061198	Q9NQX4	MYO5C_HUMAN	myosin VC	1169	Potential.					myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			ovary(7)|central_nervous_system(3)|large_intestine(2)|skin(2)	14				all cancers(107;0.0137)		CTTTGAAGTTCAAAGCTTCAA	0.398		NA											19	39					0	0	0	0
WDR72	256764	broad.mit.edu	37	15	53994481	53994481	+	Silent	SNP	G	G	C			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr15:53994481G>C	uc002acj.2	-	12	1461	c.1419C>G	c.(1417-1419)CTC>CTG	p.L473L	WDR72_uc010bfi.1_Silent_p.L473L	NM_182758	NP_877435	Q3MJ13	WDR72_HUMAN	WD repeat domain 72	473	WD 6.									lung(1)|skin(1)	2				all cancers(107;0.0511)		ATTTCGAAGAGAGACCATGTG	0.378		NA											6	98					0	0	0	0
CCPG1	9236	broad.mit.edu	37	15	55653023	55653023	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr15:55653023C>G	uc002acv.1	-	8	1113	c.948G>C	c.(946-948)AAG>AAC	p.K316N	CCPG1_uc002acy.2_Missense_Mutation_p.K316N|CCPG1_uc002acu.1_Missense_Mutation_p.K172N|CCPG1_uc002acw.1_Missense_Mutation_p.K41N|CCPG1_uc002acx.2_Intron|CCPG1_uc010bfk.1_Missense_Mutation_p.K316N|CCPG1_uc002acz.1_Missense_Mutation_p.K316N	NM_020739	NP_065790	Q9ULG6	CCPG1_HUMAN	cell cycle progression 1 isoform 2	316	Potential.|Lumenal (Potential).				cell cycle	integral to membrane				ovary(1)	1				all cancers(107;0.0354)		CTTTTTCTTCCTTCTCCAAGG	0.358		NA											3	54					0	0	0	0
VPS13C	54832	broad.mit.edu	37	15	62258317	62258317	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr15:62258317G>A	uc002agz.2	-	30	3090	c.3016C>T	c.(3016-3018)CAA>TAA	p.Q1006*	VPS13C_uc002aha.2_Nonsense_Mutation_p.Q963*|VPS13C_uc002ahb.1_Nonsense_Mutation_p.Q1006*|VPS13C_uc002ahc.1_Nonsense_Mutation_p.Q963*	NM_020821	NP_065872	Q709C8	VP13C_HUMAN	vacuolar protein sorting 13C protein isoform 2A	1006					protein localization					ovary(2)	2						AAAGCAGTTTGAAAACTAGGT	0.308		NA											14	22					0	0	0	0
TLN2	83660	broad.mit.edu	37	15	63017195	63017195	+	Silent	SNP	G	G	C			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr15:63017195G>C	uc002alb.3	+	24	3147	c.3147G>C	c.(3145-3147)CCG>CCC	p.P1049P		NM_015059	NP_055874	Q9Y4G6	TLN2_HUMAN	talin 2	1049	Ala-rich.				cell adhesion|cell-cell junction assembly|cytoskeletal anchoring at plasma membrane	actin cytoskeleton|cytoplasm|focal adhesion|ruffle|synapse	actin binding|insulin receptor binding|structural constituent of cytoskeleton			ovary(5)|upper_aerodigestive_tract(2)|lung(2)|breast(2)	11						CTTGTGGTCCGATGGAAATCG	0.493		NA											16	24					0	0	0	0
DIS3L	115752	broad.mit.edu	37	15	66601162	66601162	+	Missense_Mutation	SNP	G	G	T			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr15:66601162G>T	uc010ujm.1	+	4	553	c.538G>T	c.(538-540)GTA>TTA	p.V180L	DIS3L_uc010ujl.1_5'UTR|DIS3L_uc002app.2_Missense_Mutation_p.V97L|DIS3L_uc002apq.2_Missense_Mutation_p.V180L|DIS3L_uc010bho.2_Missense_Mutation_p.V46L	NM_001143688	NP_001137160	Q8TF46	DI3L1_HUMAN	DIS3 mitotic control homolog (S.	180					rRNA catabolic process	cytoplasm|exosome (RNase complex)	exonuclease activity|protein binding|ribonuclease activity|RNA binding			ovary(2)	2						AACAGAAGGAGTATTCGTGAT	0.398		NA											33	58					1.84e-18	1.96e-18	1	0
LRRC49	54839	broad.mit.edu	37	15	71302304	71302304	+	Silent	SNP	C	C	T			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr15:71302304C>T	uc002asw.2	+	13	1813	c.1566C>T	c.(1564-1566)TTC>TTT	p.F522F	LRRC49_uc002asu.2_Silent_p.F512F|LRRC49_uc002asx.2_Silent_p.F478F|LRRC49_uc010ukf.1_Silent_p.F527F|LRRC49_uc002asy.2_Silent_p.F228F|LRRC49_uc002asz.2_Silent_p.F494F	NM_017691	NP_060161	Q8IUZ0	LRC49_HUMAN	leucine rich repeat containing 49	522						cytoplasm|microtubule				ovary(1)	1						TAAGCCATTTCAGTATGCAGA	0.318		NA											17	22					0	0	0	0
CCDC33	80125	broad.mit.edu	37	15	74536424	74536424	+	Silent	SNP	C	C	T			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr15:74536424C>T	uc002axo.2	+	2	514	c.120C>T	c.(118-120)ACC>ACT	p.T40T		NM_025055	NP_079331	Q8N5R6	CCD33_HUMAN	coiled-coil domain containing 33 isoform 1	243	C2.						protein binding			ovary(3)|skin(2)	5						TCATGGTCACCCTCCATGGGG	0.607		NA											20	31					0	0	0	0
MTHFS	10588	broad.mit.edu	37	15	80181621	80181621	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr15:80181621C>G	uc002bex.3	-	2	233	c.193G>C	c.(193-195)GAA>CAA	p.E65Q		NM_006441	NP_006432	P49914	MTHFS_HUMAN	5,10-methenyltetrahydrofolate synthetase	65					folic acid-containing compound biosynthetic process|formate metabolic process|tetrahydrofolate metabolic process	cytosol|Golgi apparatus|plasma membrane	5-formyltetrahydrofolate cyclo-ligase activity|ATP binding|folic acid binding				0				all cancers(203;0.00467)		ATGATCTCTTCTGTCTCAATT	0.408		NA											30	45					0	0	0	0
AGBL1	123624	broad.mit.edu	37	15	86697725	86697725	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr15:86697725G>C	uc002blz.1	+	3	269	c.189G>C	c.(187-189)AGG>AGC	p.R63S		NM_152336	NP_689549	Q96MI9	CBPC4_HUMAN	ATP/GTP binding protein-like 1	63					C-terminal protein deglutamylation|protein side chain deglutamylation|proteolysis	cytosol	metallocarboxypeptidase activity|tubulin binding|zinc ion binding				0						TTCTGGCCAGGAAGAACCTAT	0.478		NA											7	15					0	0	0	0
BTBD12	84464	broad.mit.edu	37	16	3656527	3656527	+	Silent	SNP	C	C	T			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr16:3656527C>T	uc002cvp.2	-	3	1335	c.708G>A	c.(706-708)GCG>GCA	p.A236A	BTBD12_uc002cvq.1_Silent_p.A236A	NM_032444	NP_115820	Q8IY92	SLX4_HUMAN	BTB (POZ) domain containing 12	236	Interaction with C20orf94, ERCC4 and MSH2.				DNA double-strand break processing involved in repair via single-strand annealing|double-strand break repair via homologous recombination|nucleotide-excision repair	Slx1-Slx4 complex	enzyme activator activity|protein binding				0						TTTCTTCCCGCGCAGCCTCGA	0.512		NA						Direct_reversal_of_damage|Homologous_recombination	Fanconi_Anemia				69	122					0	0	0	0
DNAJA3	9093	broad.mit.edu	37	16	4491549	4491549	+	Missense_Mutation	SNP	C	C	G	rs141103865		TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr16:4491549C>G	uc002cwk.2	+	4	628	c.603C>G	c.(601-603)TTC>TTG	p.F201L	DNAJA3_uc002cwl.2_Missense_Mutation_p.F201L|DNAJA3_uc010uxk.1_Missense_Mutation_p.F48L	NM_005147	NP_005138	Q96EY1	DNJA3_HUMAN	DnaJ (Hsp40) homolog, subfamily A, member 3	201					activation of caspase activity|negative regulation of apoptosis|negative regulation of caspase activity|negative regulation of cell proliferation|negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of interferon-gamma-mediated signaling pathway|negative regulation of NF-kappaB transcription factor activity|negative regulation of protein kinase activity|neuromuscular junction development|positive regulation of apoptosis|positive regulation of protein ubiquitination|protein folding|protein folding|protein stabilization|response to heat|response to interferon-gamma	cytosol|mitochondrial matrix|mitochondrial nucleoid|nucleus	ATP binding|heat shock protein binding|interferon-gamma receptor binding|metal ion binding|NF-kappaB binding|protein kinase binding			ovary(2)|breast(2)	4						TTGGAGATTTCCAGACCGTGT	0.443		NA											14	40					0	0	0	0
NAGPA	51172	broad.mit.edu	37	16	5081854	5081854	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr16:5081854C>T	uc002cyg.2	-	3	595	c.574G>A	c.(574-576)GAG>AAG	p.E192K	ALG1_uc002cyj.2_5'Flank|NAGPA_uc010buc.2_5'Flank|NAGPA_uc002cyf.2_Missense_Mutation_p.E50K|NAGPA_uc002cyh.2_RNA|NAGPA_uc002cyi.2_Intron|NAGPA_uc010uxx.1_3'UTR	NM_016256	NP_057340	Q9UK23	NAGPA_HUMAN	N-acetylglucosamine-1-phosphodiester	192	Lumenal (Potential).				carbohydrate metabolic process|lysosome organization|protein modification process|protein targeting to lysosome	Golgi cisterna membrane|integral to membrane	N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase activity				0					N-Acetyl-D-glucosamine(DB00141)	AATGGGTTCTCAGTGTCCAGC	0.557		NA											8	93					0	0	0	0
RRN3	54700	broad.mit.edu	37	16	15180300	15180300	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr16:15180300G>C	uc002dde.2	-	4	332	c.264C>G	c.(262-264)ATC>ATG	p.I88M	PDXDC1_uc002ddc.2_Intron|RRN3_uc010uzp.1_Translation_Start_Site|RRN3_uc010uzq.1_Intron|RRN3_uc002ddf.1_Missense_Mutation_p.I88M	NM_018427	NP_060897	Q9NYV6	RRN3_HUMAN	RRN3 RNA polymerase I transcription factor	88					regulation of transcription, DNA-dependent|transcription initiation from RNA polymerase I promoter	nucleolus|nucleoplasm				ovary(1)	1						GCCAGTTGATGATCTGGTCAT	0.303		NA											4	73					0	0	0	0
SMG1	23049	broad.mit.edu	37	16	18887543	18887543	+	Missense_Mutation	SNP	T	T	A			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr16:18887543T>A	uc002dfm.2	-	13	2156	c.1793A>T	c.(1792-1794)AAG>ATG	p.K598M	SMG1_uc010bwb.2_Missense_Mutation_p.K458M	NM_015092	NP_055907	Q96Q15	SMG1_HUMAN	PI-3-kinase-related kinase SMG-1	598	Interaction with SMG8 and SMG9.				DNA repair|mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|peptidyl-serine phosphorylation|phosphatidylinositol phosphorylation|protein autophosphorylation	cytoplasm|nucleus	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			breast(5)|stomach(4)|lung(4)|kidney(2)|ovary(1)	16						CACATGATTCTTAAAAGCCTC	0.373		NA											28	62					0	0	0	0
C16orf62	57020	broad.mit.edu	37	16	19663399	19663399	+	Missense_Mutation	SNP	G	G	T			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr16:19663399G>T	uc002dgn.1	+	26	2220	c.2208G>T	c.(2206-2208)CAG>CAT	p.Q736H	C16orf62_uc002dgo.1_Missense_Mutation_p.Q643H|C16orf62_uc002dgp.1_Missense_Mutation_p.Q485H	NM_020314	NP_064710	Q7Z3J2	CP062_HUMAN	hypothetical protein LOC57020	736						integral to membrane				ovary(1)	1						TGGCCAACCAGTGCCTCTCCC	0.542		NA											7	6					5.18e-06	5.38e-06	1	0
USP31	57478	broad.mit.edu	37	16	23116857	23116857	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr16:23116857G>C	uc002dll.2	-	5	994	c.994C>G	c.(994-996)CAC>GAC	p.H332D		NM_020718	NP_065769	Q70CQ4	UBP31_HUMAN	ubiquitin specific peptidase 31	332					ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity			ovary(3)|lung(3)|breast(2)|pancreas(1)|skin(1)	10				GBM - Glioblastoma multiforme(48;0.0187)		CTCATGCAGTGAGAACATTTG	0.438		NA											10	33					0	0	0	0
COG7	91949	broad.mit.edu	37	16	23436072	23436072	+	Missense_Mutation	SNP	A	A	T			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr16:23436072A>T	uc002dlo.2	-	7	1195	c.1007T>A	c.(1006-1008)CTA>CAA	p.L336Q		NM_153603	NP_705831	P83436	COG7_HUMAN	component of oligomeric golgi complex 7	336					intracellular protein transport|protein glycosylation|protein localization in Golgi apparatus|protein stabilization|retrograde vesicle-mediated transport, Golgi to ER	Golgi membrane|Golgi transport complex	protein binding				0				GBM - Glioblastoma multiforme(48;0.0401)		ATGTTTACGTAGGTGGGGGAG	0.557		NA											31	59					0	0	0	0
CORO1A	11151	broad.mit.edu	37	16	30199516	30199516	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr16:30199516C>G	uc002dww.2	+	9	1133	c.1011C>G	c.(1009-1011)TTC>TTG	p.F337L	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|CORO1A_uc010bzq.2_Missense_Mutation_p.F337L|CORO1A_uc010bzr.2_Missense_Mutation_p.F337L|CORO1A_uc002dwx.2_Missense_Mutation_p.F231L|CORO1A_uc002dwy.1_3'UTR|LOC606724_uc002dwz.1_5'Flank	NM_007074	NP_009005	P31146	COR1A_HUMAN	coronin, actin binding protein, 1A	337	WD 7.				cell-substrate adhesion|innate immune response|leukocyte chemotaxis|negative regulation of actin nucleation|phagolysosome assembly|positive chemotaxis|regulation of cell shape|uropod organization	actin filament|cortical actin cytoskeleton|lamellipodium|phagocytic cup|phagocytic vesicle membrane	actin filament binding|phosphatidylinositol 3-kinase binding|protein C-terminus binding|protein homodimerization activity				0						CCCACAGGTTCTACAAGCTGC	0.662		NA											3	39					0	0	0	0
ZNF423	23090	broad.mit.edu	37	16	49559375	49559375	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr16:49559375C>T	uc002efs.2	-	7	3906	c.3608G>A	c.(3607-3609)TGC>TAC	p.C1203Y	ZNF423_uc010vgn.1_Missense_Mutation_p.C1086Y	NM_015069	NP_055884	Q2M1K9	ZN423_HUMAN	zinc finger protein 423	1203	C2H2-type 28.				cell differentiation|negative regulation of transcription, DNA-dependent|nervous system development|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(1)|lung(1)|kidney(1)|pancreas(1)	4		all_cancers(37;0.0155)				CATCTGGTTGCACAGCTTACA	0.572		NA											4	22					0	0	0	0
NUP93	9688	broad.mit.edu	37	16	56875739	56875739	+	Silent	SNP	C	C	T			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr16:56875739C>T	uc002eka.2	+	21	2464	c.2343C>T	c.(2341-2343)CGC>CGT	p.R781R	NUP93_uc002ekb.2_Silent_p.R658R|NUP93_uc010vhi.1_Silent_p.R658R	NM_014669	NP_055484	Q8N1F7	NUP93_HUMAN	nucleoporin 93kDa	781					carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear pore	protein binding			ovary(1)|lung(1)	2						TCGAGGACCGCGACTCTGTAA	0.512		NA											21	10					0	0	0	0
CDH11	1009	broad.mit.edu	37	16	65032599	65032599	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr16:65032599G>A	uc002eoi.2	-	4	823	c.389C>T	c.(388-390)GCG>GTG	p.A130V	CDH11_uc010cdn.2_RNA|CDH11_uc002eoj.2_Missense_Mutation_p.A130V|CDH11_uc010vin.1_Missense_Mutation_p.A4V|CDH11_uc010vio.1_Missense_Mutation_p.A130V	NM_001797	NP_001788	P55287	CAD11_HUMAN	cadherin 11, type 2 preproprotein	130	Extracellular (Potential).|Cadherin 1.				adherens junction organization|cell junction assembly|homophilic cell adhesion|ossification|skeletal system development	integral to membrane|plasma membrane	calcium ion binding|protein binding			lung(10)|ovary(3)|skin(1)	14		Ovarian(137;0.0973)		OV - Ovarian serous cystadenocarcinoma(108;0.205)		CCTGTCCACCGCCTGAGCCAT	0.527		NA	T	USP6	aneurysmal bone cysts					TSP Lung(24;0.17)			17	7					0	0	0	0
MYO1C	4641	broad.mit.edu	37	17	1373933	1373933	+	Missense_Mutation	SNP	G	G	T			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr17:1373933G>T	uc002fsp.2	-	22	2483	c.2263C>A	c.(2263-2265)CTC>ATC	p.L755I	MYO1C_uc002fsn.2_Missense_Mutation_p.L736I|MYO1C_uc002fso.2_Missense_Mutation_p.L720I|MYO1C_uc010vqj.1_Missense_Mutation_p.L720I|MYO1C_uc010vqk.1_Missense_Mutation_p.L731I	NM_001080779	NP_001074248	O00159	MYO1C_HUMAN	myosin IC isoform a	755	IQ 1.				mRNA transport|protein transport|transmembrane transport	basal plasma membrane|cytoplasm|filamentous actin|lateral plasma membrane|nuclear pore|nucleolus|nucleoplasm|stereocilium membrane	actin binding|ATP binding|calmodulin binding|motor activity				0				UCEC - Uterine corpus endometrioid carcinoma (25;0.0822)		TTCACCCGGAGGAATTTCTGC	0.622		NA											10	21					0.000219431	0.000225544	1	0
ZZEF1	23140	broad.mit.edu	37	17	3928237	3928237	+	Silent	SNP	C	C	T			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr17:3928237C>T	uc002fxe.2	-	43	7132	c.7068G>A	c.(7066-7068)CTG>CTA	p.L2356L	ZZEF1_uc002fxh.2_Silent_p.L670L|ZZEF1_uc002fxi.2_Silent_p.L591L	NM_015113	NP_055928	O43149	ZZEF1_HUMAN	zinc finger, ZZ type with EF hand domain 1	2356							calcium ion binding|zinc ion binding			ovary(2)|central_nervous_system(1)|pancreas(1)	4						ACAATCCTTTCAGGGCCAGGG	0.493		NA											8	108					0	0	0	0
POLR2A	5430	broad.mit.edu	37	17	7404130	7404130	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr17:7404130G>A	uc002ghf.3	+	11	2078	c.1844G>A	c.(1843-1845)AGT>AAT	p.S615N		NM_000937	NP_000928	P24928	RPB1_HUMAN	DNA-directed RNA polymerase II A	615					mRNA capping|nuclear mRNA splicing, via spliceosome|positive regulation of viral transcription|protein phosphorylation|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	DNA-directed RNA polymerase II, core complex	DNA binding|DNA-directed RNA polymerase activity|metal ion binding|RNA-directed RNA polymerase activity|ubiquitin protein ligase binding			pancreas(1)	1		Prostate(122;0.173)				GATGAAGACAGTGGCCCTTAC	0.547		NA											98	7					0	0	0	0
TP53	7157	broad.mit.edu	37	17	7577085	7577085	+	Missense_Mutation	SNP	C	C	T	rs112431538		TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr17:7577085C>T	uc002gim.2	-	8	1047	c.853G>A	c.(853-855)GAG>AAG	p.E285K	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Missense_Mutation_p.E285K|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.E153K|TP53_uc010cng.1_Missense_Mutation_p.E153K|TP53_uc002gii.1_Missense_Mutation_p.E153K|TP53_uc010cnh.1_Missense_Mutation_p.E285K|TP53_uc010cni.1_Missense_Mutation_p.E285K|TP53_uc002gij.2_Missense_Mutation_p.E285K	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	285	|Interaction with E4F1.|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		E -> K (in sporadic cancers; somatic mutation).|E -> V (in sporadic cancers; somatic mutation).|E -> Q (in LFS; germline mutation and in sporadic cancers; somatic mutation).|E -> A (in a sporadic cancer; somatic mutation).|E -> G (in sporadic cancers; somatic mutation).|E -> D (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.E285K(95)|p.E285*(16)|p.E285V(13)|p.0?(7)|p.E285Q(4)|p.E285E(3)|p.E285G(3)|p.E285A(2)|p.?(2)|p.R283fs*16(2)|p.E285_N288delEEEN(1)|p.R282_E287delRRTEEE(1)|p.T284_G293del10(1)|p.G279fs*59(1)|p.E285fs*13(1)|p.L265_K305del41(1)|p.T284fs*57(1)|p.R283fs*56(1)|p.V272_K292del21(1)|p.R283fs*59(1)|p.C275fs*20(1)|p.E285_L289delEEENL(1)|p.E285fs*60(1)|p.E285fs*20(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		TTCTCTTCCTCTGTGCGCCGG	0.562		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			28	9					0	0	0	0
DNAH2	146754	broad.mit.edu	37	17	7735024	7735024	+	Silent	SNP	C	C	G			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr17:7735024C>G	uc002giu.1	+	81	12671	c.12657C>G	c.(12655-12657)GTC>GTG	p.V4219V	DNAH2_uc010cnm.1_Silent_p.V1157V	NM_020877	NP_065928	Q9P225	DYH2_HUMAN	dynein heavy chain domain 3	4219					ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(6)|skin(6)|central_nervous_system(1)	13		all_cancers(10;4.66e-07)|Prostate(122;0.081)				GTCTCATCGTCATGTCTACAA	0.488		NA											11	48					0	0	0	0
NCOR1	9611	broad.mit.edu	37	17	16024584	16024584	+	Splice_Site	SNP	C	C	T			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr17:16024584C>T	uc002gpo.2	-	16	1875	c.1635_splice	c.e16-1	p.K545_splice	NCOR1_uc002gpn.2_Splice_Site_p.K545_splice|NCOR1_uc002gpp.1_Splice_Site_p.K436_splice|NCOR1_uc002gpr.2_Splice_Site_p.K436_splice	NM_006311	NP_006302	O75376	NCOR1_HUMAN	nuclear receptor co-repressor 1						cellular lipid metabolic process|chromatin modification|negative regulation of JNK cascade|regulation of glycolysis by negative regulation of transcription from an RNA polymerase II promoter|regulation of lipid transport by negative regulation of transcription from an RNA polymerase II promoter|spindle assembly|transcription from RNA polymerase II promoter	nuclear chromatin|spindle microtubule|transcriptional repressor complex	histone deacetylase binding|transcription corepressor activity|transcription regulatory region DNA binding			upper_aerodigestive_tract(2)|ovary(1)|central_nervous_system(1)|kidney(1)	5				UCEC - Uterine corpus endometrioid carcinoma (92;0.101)		GGTATTTTCTCTGGACACAAA	0.383		NA											5	132					0	0	0	0
MYO15A	51168	broad.mit.edu	37	17	18023707	18023707	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr17:18023707C>G	uc010vxh.1	+	2	1931	c.1593C>G	c.(1591-1593)TTC>TTG	p.F531L		NM_016239	NP_057323	Q9UKN7	MYO15_HUMAN	myosin XV	531	Myosin head-like.				sensory perception of sound	cytoplasm|myosin complex|stereocilium	actin binding|ATP binding|calmodulin binding|motor activity			skin(4)|ovary(2)|pancreas(1)|breast(1)|central_nervous_system(1)	9	all_neural(463;0.228)					GCCACCCTTTCTGGGGCTTCC	0.706		NA											4	9					0	0	0	0
SHMT1	6470	broad.mit.edu	37	17	18238931	18238931	+	Silent	SNP	A	A	C			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr17:18238931A>C	uc002gta.2	-	8	1063	c.873T>G	c.(871-873)CTT>CTG	p.L291L	SHMT1_uc002gsz.2_Silent_p.L66L|SHMT1_uc002gtb.2_Intron|SHMT1_uc010cqb.2_Silent_p.L291L|SHMT1_uc010vxt.1_Silent_p.L153L|SHMT1_uc002gtc.1_5'Flank|SHMT1_uc002gtd.1_Silent_p.L291L	NM_004169	NP_004160	P34896	GLYC_HUMAN	serine hydroxymethyltransferase 1 (soluble)	291					carnitine biosynthetic process|folic acid metabolic process|L-serine catabolic process|one-carbon metabolic process|purine base biosynthetic process	cytosol|nucleus	glycine hydroxymethyltransferase activity|protein homodimerization activity|pyridoxal phosphate binding			ovary(1)	1					Glycine(DB00145)|Mimosine(DB01055)|Pyridoxal Phosphate(DB00114)|Tetrahydrofolic acid(DB00116)	CAGAATTGATAAGAGACTCCA	0.502		NA											102	92					0	0	0	0
TRIM16L	147166	broad.mit.edu	37	17	18638380	18638380	+	Missense_Mutation	SNP	G	G	T			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr17:18638380G>T	uc002gug.1	+	10	1341	c.654G>T	c.(652-654)GAG>GAT	p.E218D	TRIM16L_uc010vyf.1_Missense_Mutation_p.E272D|TRIM16L_uc002guh.1_Missense_Mutation_p.E218D|TRIM16L_uc010cqg.1_Missense_Mutation_p.E320D|TRIM16L_uc002gui.1_Missense_Mutation_p.E218D|TRIM16L_uc010vyg.1_Missense_Mutation_p.E218D|TRIM16L_uc010vyh.1_Missense_Mutation_p.R131I	NM_001037330	NP_001032407	Q309B1	TR16L_HUMAN	tripartite motif-containing 16-like	218	B30.2/SPRY.					cytoplasm					0						TTGAGGTGGAGATCTTCGGGG	0.587		NA											42	2					1.42e-22	1.52e-22	1	0
ATAD5	79915	broad.mit.edu	37	17	29220591	29220591	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr17:29220591G>C	uc002hfs.1	+	21	5066	c.4720G>C	c.(4720-4722)GAT>CAT	p.D1574H		NM_024857	NP_079133	Q96QE3	ATAD5_HUMAN	ATPase family, AAA domain containing 5	1574					response to DNA damage stimulus	nucleus	ATP binding|nucleoside-triphosphatase activity			ovary(3)	3		all_hematologic(16;0.0202)|Acute lymphoblastic leukemia(14;0.0238)|Myeloproliferative disorder(56;0.0393)				GGTAATATTAGATGATAGTGA	0.358		NA											11	46					0	0	0	0
ATAD5	79915	broad.mit.edu	37	17	29221718	29221718	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr17:29221718G>C	uc002hfs.1	+	22	5780	c.5434G>C	c.(5434-5436)GAA>CAA	p.E1812Q		NM_024857	NP_079133	Q96QE3	ATAD5_HUMAN	ATPase family, AAA domain containing 5	1812					response to DNA damage stimulus	nucleus	ATP binding|nucleoside-triphosphatase activity			ovary(3)	3		all_hematologic(16;0.0202)|Acute lymphoblastic leukemia(14;0.0238)|Myeloproliferative disorder(56;0.0393)				GAAGCTAAAAGAACAAGGAAA	0.303		NA											7	36					0	0	0	0
FBXL20	84961	broad.mit.edu	37	17	37421664	37421664	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr17:37421664G>A	uc010wed.1	-	13	1197	c.976C>T	c.(976-978)CGA>TGA	p.R326*	FBXL20_uc002hrt.2_Nonsense_Mutation_p.R326*|FBXL20_uc010cvu.2_Nonsense_Mutation_p.R294*	NM_032875	NP_116264	Q96IG2	FXL20_HUMAN	F-box and leucine-rich repeat protein 20	326	LRR 10.					cytoplasm				ovary(1)	1			LUAD - Lung adenocarcinoma(14;0.146)			ACTTGAAGTCGAGGACAGTGT	0.338		NA											16	101					0	0	0	0
MED1	5469	broad.mit.edu	37	17	37565028	37565028	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr17:37565028G>A	uc002hrv.3	-	17	3658	c.3446C>T	c.(3445-3447)TCT>TTT	p.S1149F	MED1_uc010wee.1_Missense_Mutation_p.S977F|MED1_uc002hru.2_Intron	NM_004774	NP_004765	Q15648	MED1_HUMAN	mediator complex subunit 1	1149	Ser-rich.				androgen biosynthetic process|androgen receptor signaling pathway|cellular lipid metabolic process|fat cell differentiation|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|transcription initiation from RNA polymerase II promoter	mediator complex	DNA binding|estrogen receptor binding|ligand-dependent nuclear receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|peroxisome proliferator activated receptor binding|receptor activity|retinoic acid receptor binding|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			lung(2)|ovary(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	8		Ovarian(249;1.78e-06)|Lung SC(565;0.0262)	Lung(15;0.0178)|LUAD - Lung adenocarcinoma(14;0.146)	UCEC - Uterine corpus endometrioid carcinoma (308;6.64e-05)|BRCA - Breast invasive adenocarcinoma(366;0.00136)|READ - Rectum adenocarcinoma(1115;0.0649)		CTTCCCCCCAGACTGGGATGA	0.478		NA								HNSCC(31;0.082)			9	74					0	0	0	0
MED1	5469	broad.mit.edu	37	17	37565889	37565889	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr17:37565889C>T	uc002hrv.3	-	17	2797	c.2585G>A	c.(2584-2586)GGA>GAA	p.G862E	MED1_uc010wee.1_Missense_Mutation_p.G690E|MED1_uc002hru.2_Intron	NM_004774	NP_004765	Q15648	MED1_HUMAN	mediator complex subunit 1	862	Interaction with ESR1.				androgen biosynthetic process|androgen receptor signaling pathway|cellular lipid metabolic process|fat cell differentiation|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|transcription initiation from RNA polymerase II promoter	mediator complex	DNA binding|estrogen receptor binding|ligand-dependent nuclear receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|peroxisome proliferator activated receptor binding|receptor activity|retinoic acid receptor binding|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			lung(2)|ovary(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	8		Ovarian(249;1.78e-06)|Lung SC(565;0.0262)	Lung(15;0.0178)|LUAD - Lung adenocarcinoma(14;0.146)	UCEC - Uterine corpus endometrioid carcinoma (308;6.64e-05)|BRCA - Breast invasive adenocarcinoma(366;0.00136)|READ - Rectum adenocarcinoma(1115;0.0649)		GAAATCTACTCCATCATGAAA	0.388		NA								HNSCC(31;0.082)			31	223					0	0	0	0
KRT26	353288	broad.mit.edu	37	17	38928008	38928008	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr17:38928008C>G	uc002hvf.2	-	1	404	c.358G>C	c.(358-360)GAG>CAG	p.E120Q		NM_181539	NP_853517	Q7Z3Y9	K1C26_HUMAN	keratin 26	120	Rod.|Linker 1.					intermediate filament	structural molecule activity				0		Breast(137;0.00526)				TCACATTTCTCGTACCAGCCC	0.498		NA											10	104					0	0	0	0
WNK4	65266	broad.mit.edu	37	17	40932738	40932738	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr17:40932738G>C	uc002ibj.2	+	1	43	c.22G>C	c.(22-24)GAG>CAG	p.E8Q	WNK4_uc010wgx.1_5'UTR|WNK4_uc002ibk.1_5'Flank	NM_032387	NP_115763	Q96J92	WNK4_HUMAN	WNK lysine deficient protein kinase 4	8					intracellular protein kinase cascade	tight junction	ATP binding|protein serine/threonine kinase activity			ovary(3)|skin(3)|stomach(1)	7		Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.0749)		CCCGGCCACGGAGACCACCGT	0.711		NA											9	6					0	0	0	0
CACNA1G	8913	broad.mit.edu	37	17	48678415	48678416	+	Missense_Mutation	DNP	CC	CC	TT			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr17:48678415_48678416CC>TT	uc002irk.1	+	19	4167_4168	c.3795_3796CC>TT	c.(3793-3798)TTCCGC>TTTTGC	p.R1266C	CACNA1G_uc002iri.1_Missense_Mutation_p.R1266C|CACNA1G_uc002irj.1_Missense_Mutation_p.R1243C|CACNA1G_uc002irl.1_Missense_Mutation_p.R1243C|CACNA1G_uc002irm.1_Missense_Mutation_p.R1243C|CACNA1G_uc002irn.1_Missense_Mutation_p.R1243C|CACNA1G_uc002iro.1_Missense_Mutation_p.R1243C|CACNA1G_uc002irp.1_Missense_Mutation_p.R1266C|CACNA1G_uc002irq.1_Missense_Mutation_p.R1243C|CACNA1G_uc002irr.1_Missense_Mutation_p.R1266C|CACNA1G_uc002irs.1_Missense_Mutation_p.R1266C|CACNA1G_uc002irt.1_Missense_Mutation_p.R1266C|CACNA1G_uc002irv.1_Missense_Mutation_p.R1266C|CACNA1G_uc002irw.1_Missense_Mutation_p.R1243C|CACNA1G_uc002iru.1_Missense_Mutation_p.R1243C|CACNA1G_uc002irx.1_Missense_Mutation_p.R1179C|CACNA1G_uc002iry.1_Missense_Mutation_p.R1179C|CACNA1G_uc002irz.1_Missense_Mutation_p.R1179C|CACNA1G_uc002isa.1_Missense_Mutation_p.R1179C|CACNA1G_uc002isb.1_Missense_Mutation_p.R1179C|CACNA1G_uc002isc.1_Missense_Mutation_p.R1179C|CACNA1G_uc002isd.1_Missense_Mutation_p.R1179C|CACNA1G_uc002ise.1_Missense_Mutation_p.R1179C|CACNA1G_uc002isf.1_Missense_Mutation_p.R1179C|CACNA1G_uc002isg.1_Missense_Mutation_p.R1179C|CACNA1G_uc002ish.1_Missense_Mutation_p.R1179C|CACNA1G_uc002isi.1_Missense_Mutation_p.R1156C|CACNA1G_uc002isj.2_5'UTR	NM_018896	NP_061496	O43497	CAC1G_HUMAN	voltage-dependent calcium channel alpha 1G	1266	Cytoplasmic (Potential).|III.				axon guidance	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(1)	1	Breast(11;6.7e-17)		BRCA - Breast invasive adenocarcinoma(22;7.52e-09)		Ethosuximide(DB00593)|Flunarizine(DB04841)|Levetiracetam(DB01202)|Mibefradil(DB01388)|Pimozide(DB01100)|Trimethadione(DB00347)|Verapamil(DB00661)|Zonisamide(DB00909)	TGGGCAGGTTCCGCCTCCTGTG	0.639		NA											3	47					0	0	0	0
SPAG9	9043	broad.mit.edu	37	17	49057213	49057213	+	Silent	SNP	G	G	C	rs149696370		TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr17:49057213G>C	uc002itc.2	-	26	3512	c.3303C>G	c.(3301-3303)GGC>GGG	p.G1101G	SPAG9_uc002itb.2_Silent_p.G1087G|SPAG9_uc002itd.2_Silent_p.G1091G|SPAG9_uc002ita.2_Silent_p.G944G	NM_001130528	NP_001124000	O60271	JIP4_HUMAN	sperm associated antigen 9 isoform 1	1101					positive regulation of cell migration|positive regulation of muscle cell differentiation|retrograde transport, endosome to Golgi|spermatogenesis	acrosomal vesicle|integral to membrane|perinuclear region of cytoplasm				lung(4)|breast(1)	5			BRCA - Breast invasive adenocarcinoma(22;4.24e-07)			AGACCCACACGCCATCCCCCA	0.473		NA											26	14					0	0	0	0
CSH2	1443	broad.mit.edu	37	17	61949939	61949939	+	Missense_Mutation	SNP	C	C	A			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr17:61949939C>A	uc002jch.2	-	4	569	c.454G>T	c.(454-456)GGG>TGG	p.G152W	CSH2_uc002jcg.2_Intron|CSH2_uc002jci.2_Missense_Mutation_p.G152W|GH2_uc002jcj.2_Intron|CSH2_uc002jck.2_Missense_Mutation_p.G152W	NM_020991	NP_066271	P01243	CSH_HUMAN	chorionic somatomammotropin hormone 2 isoform 1	152					female pregnancy|signal transduction	extracellular region	hormone activity|metal ion binding				0						ACCCTCACCCCCATCAGCGTT	0.582		NA											14	84					8.6e-14	9.13e-14	1	0
PRKCA	5578	broad.mit.edu	37	17	64299066	64299066	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr17:64299066G>C	uc002jfp.1	+	1	141	c.97G>C	c.(97-99)GAG>CAG	p.E33Q	PRKCA_uc002jfo.1_5'UTR	NM_002737	NP_002728	P17252	KPCA_HUMAN	protein kinase C, alpha	33					activation of phospholipase C activity|energy reserve metabolic process|induction of apoptosis by extracellular signals|intracellular signal transduction|mRNA metabolic process|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of blood vessel endothelial cell migration|regulation of insulin secretion|response to interleukin-1|synaptic transmission	cytosol|endoplasmic reticulum|membrane fraction|nucleoplasm|plasma membrane	ATP binding|enzyme binding|histone kinase activity (H3-T6 specific)|protein kinase C activity|zinc ion binding			central_nervous_system(4)|large_intestine(1)|stomach(1)|lung(1)|breast(1)|ovary(1)	9			BRCA - Breast invasive adenocarcinoma(6;4.68e-09)		Phosphatidylserine(DB00144)|Vitamin E(DB00163)	GAACGTGCACGAGGTGAAGGA	0.627		NA											21	40					0	0	0	0
HELZ	9931	broad.mit.edu	37	17	65119122	65119122	+	Silent	SNP	G	G	C			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr17:65119122G>C	uc010wqk.1	-	26	3784	c.3597C>G	c.(3595-3597)GTC>GTG	p.V1199V	HELZ_uc002jfv.3_RNA|HELZ_uc002jfx.3_Silent_p.V1198V	NM_014877	NP_055692			helicase with zinc finger domain											ovary(1)|pancreas(1)	2	all_cancers(12;1.24e-11)|Breast(2;1.05e-17)|all_epithelial(3;3.87e-13)					TCCCTCCATAGACAGCAGGTA	0.408		NA											9	86					0	0	0	0
QRICH2	84074	broad.mit.edu	37	17	74287156	74287156	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr17:74287156C>G	uc002jrd.1	-	4	3334	c.3154G>C	c.(3154-3156)GAT>CAT	p.D1052H	QRICH2_uc010wsz.1_Missense_Mutation_p.D978H|QRICH2_uc010dgw.1_Intron	NM_032134	NP_115510	Q9H0J4	QRIC2_HUMAN	glutamine rich 2	1052							protein binding			ovary(1)|pancreas(1)|lung(1)|central_nervous_system(1)|skin(1)	5						TGCTCCTCATCCAGATCCTTC	0.527		NA											32	63					0	0	0	0
ENPP7	339221	broad.mit.edu	37	17	77710865	77710865	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr17:77710865G>A	uc002jxa.2	+	4	1072	c.1052G>A	c.(1051-1053)GGG>GAG	p.G351E		NM_178543	NP_848638	Q6UWV6	ENPP7_HUMAN	ectonucleotide pyrophosphatase/phosphodiesterase	351					negative regulation of cell proliferation|negative regulation of DNA replication|sphingomyelin metabolic process	Golgi apparatus|integral to membrane|microvillus	sphingomyelin phosphodiesterase activity			central_nervous_system(2)|ovary(1)	3			OV - Ovarian serous cystadenocarcinoma(97;0.016)|BRCA - Breast invasive adenocarcinoma(99;0.0224)			TTCAACAATGGGGAGCACGGC	0.602		NA											28	6					0	0	0	0
RNF213	57674	broad.mit.edu	37	17	78321903	78321903	+	Silent	SNP	G	G	A			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr17:78321903G>A	uc002jyh.1	+	4	4210	c.3987G>A	c.(3985-3987)TCG>TCA	p.S1329S		NM_020914	NP_065965	Q9HCF4	ALO17_HUMAN	ring finger protein 213	Error:Variant_position_missing_in_Q9HCF4_after_alignment										ovary(8)|lung(6)|breast(3)|large_intestine(2)|central_nervous_system(1)|pancreas(1)	21	all_neural(118;0.0538)		BRCA - Breast invasive adenocarcinoma(99;0.0252)|OV - Ovarian serous cystadenocarcinoma(97;0.057)			AGGCCAAATCGATCCTGCTGA	0.642		NA											37	6					0	0	0	0
ZNF750	79755	broad.mit.edu	37	17	80789425	80789425	+	Nonsense_Mutation	SNP	G	G	C			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr17:80789425G>C	uc002kga.2	-	2	1217	c.906C>G	c.(904-906)TAC>TAG	p.Y302*	TBCD_uc002kfx.1_Intron|TBCD_uc002kfy.1_Intron|TBCD_uc002kfz.2_Intron	NM_024702	NP_078978	Q32MQ0	ZN750_HUMAN	zinc finger protein 750	302						intracellular	zinc ion binding			central_nervous_system(1)	1	Breast(20;0.000523)|all_neural(118;0.0779)	all_cancers(8;0.0514)|all_epithelial(8;0.0748)	OV - Ovarian serous cystadenocarcinoma(97;0.0868)|BRCA - Breast invasive adenocarcinoma(99;0.149)			TGTAGTGATCGTATGTGGCTG	0.547		NA											115	31					0	0	0	0
COLEC12	81035	broad.mit.edu	37	18	346848	346848	+	Silent	SNP	C	C	T			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr18:346848C>T	uc002kkm.2	-	5	989	c.774G>A	c.(772-774)CTG>CTA	p.L258L		NM_130386	NP_569057	Q5KU26	COL12_HUMAN	collectin sub-family member 12	258	Potential.|Extracellular (Potential).				carbohydrate mediated signaling|innate immune response|phagocytosis, recognition|protein homooligomerization	collagen|integral to membrane	galactose binding|low-density lipoprotein particle binding|metal ion binding|pattern recognition receptor activity|scavenger receptor activity			ovary(1)|pancreas(1)	2		all_cancers(4;0.0442)|Myeloproliferative disorder(11;0.0426)				CTTTCTCCTTCAGCCAATCCG	0.512		NA											9	30					0	0	0	0
CTAGE1	64693	broad.mit.edu	37	18	19995601	19995601	+	Missense_Mutation	SNP	G	G	T			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr18:19995601G>T	uc002ktv.1	-	1	2278	c.2174C>A	c.(2173-2175)CCG>CAG	p.P725Q		NM_172241	NP_758441	Q96RT6	CTGE2_HUMAN	cutaneous T-cell lymphoma-associated antigen 1	725	Pro-rich.					integral to membrane				ovary(1)	1	all_cancers(21;0.000361)|all_epithelial(16;9.61e-06)|Colorectal(14;0.0533)|Lung NSC(20;0.0605)|Ovarian(2;0.116)|all_lung(20;0.135)					AAAACCTCTCGGTAAATAGAC	0.498		NA											22	26					5.26e-13	5.57e-13	1	0
KIAA1012	22878	broad.mit.edu	37	18	29437875	29437875	+	Missense_Mutation	SNP	T	T	C			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr18:29437875T>C	uc002kxc.3	-	20	3180	c.2816A>G	c.(2815-2817)AAT>AGT	p.N939S	KIAA1012_uc002kxb.3_Missense_Mutation_p.N885S|KIAA1012_uc002kxd.3_Intron	NM_014939	NP_055754	Q9Y2L5	TPPC8_HUMAN	hypothetical protein LOC22878	939					ER to Golgi vesicle-mediated transport	cis-Golgi network					0						TTTGCTGACATTGACAAATTC	0.378		NA											58	98					0	0	0	0
SETBP1	26040	broad.mit.edu	37	18	42532870	42532870	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr18:42532870C>T	uc010dni.2	+	4	3861	c.3565C>T	c.(3565-3567)CGG>TGG	p.R1189W		NM_015559	NP_056374	Q9Y6X0	SETBP_HUMAN	SET binding protein 1 isoform a	1189						nucleus	DNA binding			upper_aerodigestive_tract(2)|large_intestine(1)	3				Colorectal(1;0.0622)|COAD - Colon adenocarcinoma(74;0.201)		CCTGAGCGAGCGGCTGAGTAG	0.552		NA							Schinzel-Giedion_syndrome				3	43					0	0	0	0
CDH7	1005	broad.mit.edu	37	18	63489364	63489364	+	Missense_Mutation	SNP	C	C	A			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr18:63489364C>A	uc002ljz.2	+	5	998	c.673C>A	c.(673-675)CAG>AAG	p.Q225K	CDH7_uc002lka.2_Missense_Mutation_p.Q225K|CDH7_uc002lkb.2_Missense_Mutation_p.Q225K	NM_033646	NP_387450	Q9ULB5	CADH7_HUMAN	cadherin 7, type 2 preproprotein	225	Extracellular (Potential).|Cadherin 2.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)|pancreas(1)|skin(1)	4		Esophageal squamous(42;0.129)				GGCTAAAGACCAGTATTTGCT	0.403		NA											18	34					5.35e-07	5.59e-07	1	0
CTDP1	9150	broad.mit.edu	37	18	77513778	77513778	+	Silent	SNP	C	C	T			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr18:77513778C>T	uc002lnh.1	+	13	3021	c.2874C>T	c.(2872-2874)AAC>AAT	p.N958N	CTDP1_uc002lni.1_3'UTR|CTDP1_uc010drd.1_3'UTR	NM_004715	NP_004706	Q9Y5B0	CTDP1_HUMAN	CTD (carboxy-terminal domain, RNA polymerase II,	958					positive regulation of viral transcription|protein dephosphorylation|transcription elongation from RNA polymerase II promoter|viral reproduction	nucleoplasm	CTD phosphatase activity|DNA-directed RNA polymerase activity				0		Esophageal squamous(42;0.0157)|Melanoma(33;0.144)		OV - Ovarian serous cystadenocarcinoma(15;5.2e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0277)		CGGAGCTCAACGACCTCATGT	0.687		NA											9	13					0	0	0	0
APC2	10297	broad.mit.edu	37	19	1462153	1462153	+	Silent	SNP	C	C	T			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr19:1462153C>T	uc002lsr.1	+	14	2038	c.1830C>T	c.(1828-1830)CTC>CTT	p.L610L	APC2_uc002lss.1_Silent_p.L192L|APC2_uc002lst.1_Silent_p.L610L|APC2_uc002lsu.1_Silent_p.L609L|C19orf25_uc010xgn.1_Intron	NM_005883	NP_005874	O95996	APC2_HUMAN	adenomatosis polyposis coli 2	610					negative regulation of canonical Wnt receptor signaling pathway|negative regulation of catenin import into nucleus|Wnt receptor signaling pathway	actin filament|catenin complex|cytoplasmic microtubule|Golgi membrane|lamellipodium membrane|perinuclear region of cytoplasm	beta-catenin binding|microtubule binding			breast(3)|pancreas(1)	4		Acute lymphoblastic leukemia(61;3.02e-13)|all_hematologic(61;4.32e-09)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TGTCCAGCCTCGTCGCCACCC	0.692		NA											4	5					0	0	0	0
ADAMTSL5	339366	broad.mit.edu	37	19	1510410	1510410	+	Missense_Mutation	SNP	G	G	C	rs149832091		TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr19:1510410G>C	uc002ltd.2	-	4	653	c.209C>G	c.(208-210)CCG>CGG	p.P70R	ADAMTSL5_uc010dsl.2_5'UTR|ADAMTSL5_uc010xgq.1_Missense_Mutation_p.P80R	NM_213604	NP_998769	Q6ZMM2	ATL5_HUMAN	ADAMTS-like 5 precursor	70	TSP type-1.					proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding				0		Acute lymphoblastic leukemia(61;5.61e-13)|all_hematologic(61;2.65e-08)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TCCCCAGCACGGTTCTTCCCC	0.672		NA											4	12					0	0	0	0
S1PR4	8698	broad.mit.edu	37	19	3179237	3179237	+	Silent	SNP	G	G	A			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr19:3179237G>A	uc002lxg.2	+	1	472	c.447G>A	c.(445-447)CGG>CGA	p.R149R		NM_003775	NP_003766	O95977	S1PR4_HUMAN	sphingosine-1-phosphate receptor 4 precursor	149	Cytoplasmic (By similarity).				activation of phospholipase C activity|elevation of cytosolic calcium ion concentration|immune response	integral to plasma membrane	lipid binding|lysosphingolipid and lysophosphatidic acid receptor activity			lung(1)|skin(1)	2						CCATGGTGCGGCCGGTGGCCG	0.692		NA											4	66					0	0	0	0
PLIN3	10226	broad.mit.edu	37	19	4859609	4859609	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr19:4859609G>A	uc002mbj.2	-	4	518	c.341C>T	c.(340-342)ACG>ATG	p.T114M	PLIN3_uc002mbk.2_Missense_Mutation_p.T114M|PLIN3_uc002mbl.3_Missense_Mutation_p.T114M	NM_005817	NP_005808	O60664	PLIN3_HUMAN	mannose 6 phosphate receptor binding protein 1	114					vesicle-mediated transport	endosome membrane|Golgi apparatus|lipid particle	protein binding				0					Galsulfase(DB01279)|Idursulfase(DB01271)	TACCTTCTCCGTGGGCTGCTG	0.572		NA											21	29					0	0	0	0
MUC16	94025	broad.mit.edu	37	19	9085082	9085082	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr19:9085082C>T	uc002mkp.2	-	1	6937	c.6733G>A	c.(6733-6735)GAG>AAG	p.E2245K		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	2245	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GGAATACTCTCAGCCCCATCT	0.448		NA											11	19					0	0	0	0
ZNF699	374879	broad.mit.edu	37	19	9407596	9407596	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr19:9407596C>G	uc002mlc.1	-	5	484	c.484G>C	c.(484-486)GAG>CAG	p.E162Q		NM_198535	NP_940937	Q32M78	ZN699_HUMAN	zinc finger protein 699	162					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						TAGATGTTCTCTACCATATGA	0.299		NA											5	18					0	0	0	0
MAN2B1	4125	broad.mit.edu	37	19	12776599	12776599	+	Silent	SNP	C	C	T			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr19:12776599C>T	uc002mub.2	-	2	256	c.180G>A	c.(178-180)CCG>CCA	p.P60P	MAN2B1_uc010dyv.1_Silent_p.P60P|WDR83_uc002mue.3_5'Flank|WDR83_uc002muc.2_5'Flank	NM_000528	NP_000519	O00754	MA2B1_HUMAN	mannosidase, alpha, class 2B, member 1	60					protein deglycosylation	lysosome	alpha-mannosidase activity|zinc ion binding			ovary(4)|central_nervous_system(2)	6						TCAGCATGTTCGGCTGCACTG	0.547		NA											15	33					0	0	0	0
DHPS	1725	broad.mit.edu	37	19	12790281	12790281	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr19:12790281C>T	uc002muh.1	-	5	765	c.668G>A	c.(667-669)TGG>TAG	p.W223*	DHPS_uc002muf.1_Nonsense_Mutation_p.W100*|DHPS_uc002mug.1_Nonsense_Mutation_p.W181*|DHPS_uc002mui.1_Nonsense_Mutation_p.W223*|DHPS_uc002muj.1_Nonsense_Mutation_p.W223*|DHPS_uc002muk.1_RNA|DHPS_uc010xmn.1_RNA	NM_001930	NP_001921	P49366	DHYS_HUMAN	deoxyhypusine synthase isoform a	223					peptidyl-lysine modification to hypusine|positive regulation of cell proliferation|post-translational protein modification|spermidine catabolic process to deoxyhypusine, using deoxyhypusine synthase|translation	cytosol	deoxyhypusine synthase activity|protein binding			central_nervous_system(1)	1					Sulfadoxine(DB01299)	CTTCTGGGCCCAGTAATACAC	0.398		NA											72	98					0	0	0	0
CC2D1A	54862	broad.mit.edu	37	19	14038078	14038078	+	Missense_Mutation	SNP	G	G	T			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr19:14038078G>T	uc002mxo.2	+	22	2615	c.2316G>T	c.(2314-2316)GAG>GAT	p.E772D	CC2D1A_uc002mxp.2_Missense_Mutation_p.E772D|CC2D1A_uc010dzh.2_Missense_Mutation_p.E341D|CC2D1A_uc002mxq.1_3'UTR	NM_017721	NP_060191	Q6P1N0	C2D1A_HUMAN	coiled-coil and C2 domain containing 1A	772					positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus|plasma membrane	DNA binding|signal transducer activity				0			OV - Ovarian serous cystadenocarcinoma(19;3.49e-23)			AGATCCTTGAGGTGAGAGGTG	0.547		NA											3	48					6.4e-05	6.61e-05	1	0
TSSK6	83983	broad.mit.edu	37	19	19626011	19626011	+	Missense_Mutation	SNP	A	A	G			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr19:19626011A>G	uc002nmr.2	-	1	459	c.226T>C	c.(226-228)TTC>CTC	p.F76L	TSSK6_uc002nmq.2_RNA|NDUFA13_uc002nms.2_5'Flank|NDUFA13_uc010xqx.1_5'Flank|NDUFA13_uc010xqy.1_5'Flank	NM_032037	NP_114426	Q9BXA6	TSSK6_HUMAN	testis-specific serine kinase 6	76	Protein kinase.				multicellular organismal development|sperm chromatin condensation		ATP binding|magnesium ion binding|protein serine/threonine kinase activity			stomach(1)	1						ATGAACTCGAAGACGTGCACG	0.667		NA											11	26					0	0	0	0
ZNF91	7644	broad.mit.edu	37	19	23544721	23544721	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr19:23544721C>G	uc002nre.2	-	4	1173	c.1060G>C	c.(1060-1062)GAA>CAA	p.E354Q	ZNF91_uc010xrj.1_Missense_Mutation_p.E322Q	NM_003430	NP_003421	Q05481	ZNF91_HUMAN	zinc finger protein 91	354	C2H2-type 8.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		all_lung(12;0.0349)|Lung NSC(12;0.0538)|all_epithelial(12;0.0611)				TTGCCACATTCTTTACATTTG	0.368		NA											14	32					0	0	0	0
ZNF536	9745	broad.mit.edu	37	19	30935350	30935350	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr19:30935350G>A	uc002nsu.1	+	2	1019	c.881G>A	c.(880-882)CGC>CAC	p.R294H	ZNF536_uc010edd.1_Missense_Mutation_p.R294H	NM_014717	NP_055532	O15090	ZN536_HUMAN	zinc finger protein 536	294	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(7)|large_intestine(2)|skin(2)	11	Esophageal squamous(110;0.0834)					CGCCACATCCGCATCTTGCAC	0.647		NA											33	45					0	0	0	0
FCGBP	8857	broad.mit.edu	37	19	40363228	40363228	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr19:40363228C>T	uc002omp.3	-	32	14850	c.14842G>A	c.(14842-14844)GAG>AAG	p.E4948K		NM_003890	NP_003881	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein precursor	4948	VWFD 12.					extracellular region	protein binding			ovary(4)|skin(4)|central_nervous_system(1)	9	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			TTTCGGCCCTCGGCGGTCACC	0.662		NA											10	13					0	0	0	0
ZNF226	7769	broad.mit.edu	37	19	44680376	44680376	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr19:44680376C>T	uc002oyp.2	+	6	1105	c.961C>T	c.(961-963)CAT>TAT	p.H321Y	ZNF226_uc002oyq.2_Missense_Mutation_p.H204Y|ZNF226_uc002oyr.2_Missense_Mutation_p.H204Y|ZNF226_uc010ejg.2_3'UTR|ZNF226_uc002oys.2_Missense_Mutation_p.H321Y|ZNF226_uc002oyt.2_Missense_Mutation_p.H321Y	NM_001032373	NP_001027545	Q9NYT6	ZN226_HUMAN	zinc finger protein 226 isoform a	321	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Prostate(69;0.0352)|all_neural(266;0.202)				TCAGGGCGCTCATCTACAGAC	0.428		NA											5	38					0	0	0	0
ZNF320	162967	broad.mit.edu	37	19	53385154	53385154	+	Silent	SNP	C	C	T			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr19:53385154C>T	uc002qag.2	-	4	416	c.225G>A	c.(223-225)CAG>CAA	p.Q75Q	ZNF320_uc010eqh.1_5'Flank|ZNF320_uc010eqi.1_Intron|ZNF320_uc002qah.2_Silent_p.Q21Q|ZNF320_uc002qai.2_Silent_p.Q75Q	NM_207333	NP_997216	A2RRD8	ZN320_HUMAN	zinc finger protein 320	75	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				GBM - Glioblastoma multiforme(134;0.0534)		TTGCTTGTCTCTGCAATGTCC	0.393		NA											11	149					0	0	0	0
ZNF347	84671	broad.mit.edu	37	19	53652521	53652521	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr19:53652521C>G	uc002qbb.1	-	3	184	c.115G>C	c.(115-117)GAG>CAG	p.E39Q	ZNF347_uc010eql.1_Missense_Mutation_p.E39Q|ZNF347_uc002qbc.1_Missense_Mutation_p.E39Q	NM_032584	NP_115973	Q96SE7	ZN347_HUMAN	zinc finger protein 347	39	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				GBM - Glioblastoma multiforme(134;0.0179)		CTATAATTCTCCAACATCACG	0.517		NA											41	71					0	0	0	0
NLRP7	199713	broad.mit.edu	37	19	55451377	55451377	+	Silent	SNP	G	G	A			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr19:55451377G>A	uc002qih.3	-	4	886	c.810C>T	c.(808-810)TGC>TGT	p.C270C	NLRP7_uc002qig.3_Silent_p.C270C|NLRP7_uc002qii.3_Silent_p.C270C|NLRP7_uc010esk.2_Silent_p.C270C|NLRP7_uc010esl.2_Silent_p.C298C	NM_206828	NP_996611	Q8WX94	NALP7_HUMAN	NACHT, leucine rich repeat and PYD containing 7	270	NACHT.						ATP binding			large_intestine(1)|breast(1)|central_nervous_system(1)	3				GBM - Glioblastoma multiforme(193;0.0325)		CCCAGTCCCCGCAGATGTCCT	0.592		NA											28	38					0	0	0	0
U2AF2	11338	broad.mit.edu	37	19	56166482	56166482	+	Silent	SNP	C	C	T			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr19:56166482C>T	uc002qlu.2	+	1	1067	c.12C>T	c.(10-12)TTC>TTT	p.F4F	U2AF2_uc002qlt.2_Silent_p.F4F	NM_007279	NP_009210	P26368	U2AF2_HUMAN	U2 (RNU2) small nuclear RNA auxiliary factor 2	4					mRNA 3'-end processing|mRNA export from nucleus|termination of RNA polymerase II transcription	nucleoplasm|spliceosomal complex	enzyme binding|nucleotide binding|RNA binding			ovary(1)	1		Colorectal(82;0.00244)|Ovarian(87;0.133)	BRCA - Breast invasive adenocarcinoma(297;0.18)	GBM - Glioblastoma multiforme(193;0.107)		TGTCGGACTTCGACGAGTTCG	0.692		NA											6	15					0	0	0	0
SNTG2	54221	broad.mit.edu	37	2	1251141	1251141	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr2:1251141G>A	uc002qwq.2	+	12	1059	c.931G>A	c.(931-933)GAC>AAC	p.D311N	SNTG2_uc010ewi.2_Missense_Mutation_p.D184N	NM_018968	NP_061841	Q9NY99	SNTG2_HUMAN	syntrophin, gamma 2	311	PH.				central nervous system development	cytoplasm|cytoskeleton|sarcolemma|syntrophin complex	actin binding|PDZ domain binding			ovary(1)|large_intestine(1)|breast(1)	3	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.00469)		all cancers(51;0.0178)|OV - Ovarian serous cystadenocarcinoma(76;0.07)|Epithelial(75;0.0864)|GBM - Glioblastoma multiforme(21;0.173)		CCAAGGAGCTGACTCCTCTCA	0.502		NA											11	22					0	0	0	0
GREB1	9687	broad.mit.edu	37	2	11733135	11733135	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr2:11733135G>A	uc002rbk.1	+	11	1879	c.1579G>A	c.(1579-1581)GAG>AAG	p.E527K	GREB1_uc002rbo.1_Missense_Mutation_p.E161K	NM_014668	NP_055483	Q4ZG55	GREB1_HUMAN	growth regulation by estrogen in breast cancer 1	527						integral to membrane				ovary(1)	1	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.115)|OV - Ovarian serous cystadenocarcinoma(76;0.186)		CTCCCTGGCCGAGGGCCTCTC	0.667		NA											3	11					0	0	0	0
ITSN2	50618	broad.mit.edu	37	2	24480764	24480764	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr2:24480764G>A	uc002rfe.2	-	23	3139	c.2881C>T	c.(2881-2883)CGG>TGG	p.R961W	ITSN2_uc002rff.2_Missense_Mutation_p.R934W|ITSN2_uc002rfg.2_Missense_Mutation_p.R961W|ITSN2_uc002rfh.1_RNA	NM_006277	NP_006268	Q9NZM3	ITSN2_HUMAN	intersectin 2 isoform 1	961					endocytosis|regulation of Rho protein signal transduction	cytoplasm	calcium ion binding|Rho guanyl-nucleotide exchange factor activity|SH3/SH2 adaptor activity			kidney(2)|ovary(1)|central_nervous_system(1)	4	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TACTCTTCCCGTTTTACTTCA	0.403		NA											27	43					0	0	0	0
ITSN2	50618	broad.mit.edu	37	2	24494796	24494796	+	Missense_Mutation	SNP	C	C	A			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr2:24494796C>A	uc002rfe.2	-	19	2354	c.2096G>T	c.(2095-2097)GGA>GTA	p.G699V	ITSN2_uc002rff.2_Missense_Mutation_p.G672V|ITSN2_uc002rfg.2_Missense_Mutation_p.G699V	NM_006277	NP_006268	Q9NZM3	ITSN2_HUMAN	intersectin 2 isoform 1	699	Potential.				endocytosis|regulation of Rho protein signal transduction	cytoplasm	calcium ion binding|Rho guanyl-nucleotide exchange factor activity|SH3/SH2 adaptor activity			kidney(2)|ovary(1)|central_nervous_system(1)	4	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					gttttcttttccttgctttgc	0.104		NA											16	5					1.36e-06	1.42e-06	1	0
PLB1	151056	broad.mit.edu	37	2	28812554	28812554	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr2:28812554G>A	uc002rmb.1	+	28	1933	c.1933G>A	c.(1933-1935)GAC>AAC	p.D645N	PLB1_uc010ezj.1_Missense_Mutation_p.D634N|PLB1_uc002rmc.2_Missense_Mutation_p.D333N|PLB1_uc002rmd.1_Missense_Mutation_p.D155N	NM_153021	NP_694566	Q6P1J6	PLB1_HUMAN	phospholipase B1 precursor	645	4 X 308-326 AA approximate repeats.|2.|Extracellular (Potential).				lipid catabolic process|retinoid metabolic process|steroid metabolic process	apical plasma membrane|integral to membrane	lysophospholipase activity|phospholipase A2 activity|retinyl-palmitate esterase activity			ovary(4)|large_intestine(2)|skin(2)|breast(1)	9	Acute lymphoblastic leukemia(172;0.155)					AGGATTGCCTGACAACTCTTT	0.498		NA											7	72					0	0	0	0
C2orf71	388939	broad.mit.edu	37	2	29294945	29294945	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr2:29294945C>G	uc002rmt.1	-	1	2183	c.2183G>C	c.(2182-2184)AGA>ACA	p.R728T		NM_001029883	NP_001025054	A6NGG8	CB071_HUMAN	hypothetical protein LOC388939	728					response to stimulus|visual perception	photoreceptor outer segment				skin(1)	1						GACGGATGTTCTGGTGGGACA	0.547		NA											5	80					0	0	0	0
PRKD3	23683	broad.mit.edu	37	2	37520323	37520323	+	Nonsense_Mutation	SNP	G	G	C			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr2:37520323G>C	uc002rqd.2	-	2	935	c.380C>G	c.(379-381)TCA>TGA	p.S127*	PRKD3_uc002rqf.1_Nonsense_Mutation_p.S127*	NM_005813	NP_005804	O94806	KPCD3_HUMAN	protein kinase D3	127					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction	cytoplasm|membrane|nucleus	ATP binding|metal ion binding|protein binding|protein kinase C activity			lung(2)|ovary(1)|central_nervous_system(1)	4		all_hematologic(82;0.21)				TTCATCTGCTGAGGTAATCAG	0.408		NA											6	76					0	0	0	0
TMEM178	130733	broad.mit.edu	37	2	39944277	39944277	+	Silent	SNP	C	C	T			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr2:39944277C>T	uc002rrt.2	+	4	805	c.780C>T	c.(778-780)TGC>TGT	p.C260C	TMEM178_uc010fam.1_Silent_p.C214C	NM_152390	NP_689603	Q8NBL3	TM178_HUMAN	transmembrane protein 178 precursor	260	Helical; (Potential).					integral to membrane					0		all_hematologic(82;0.248)				CCATCTTTTGCGCCTGGTGCA	0.493		NA											55	71					0	0	0	0
GKN1	56287	broad.mit.edu	37	2	69206027	69206027	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr2:69206027C>T	uc002sfc.2	+	4	334	c.271C>T	c.(271-273)CAA>TAA	p.Q91*		NM_019617	NP_062563	Q9NS71	GKN1_HUMAN	18 kDa antrum mucosa protein precursor	91	BRICHOS.				digestion|positive regulation of cell division	extracellular region				breast(1)	1						CAGACTCTTTCAAAAGAAGAC	0.433		NA											4	53					0	0	0	0
POLR1A	25885	broad.mit.edu	37	2	86302279	86302279	+	Silent	SNP	G	G	A			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr2:86302279G>A	uc002sqs.2	-	12	1864	c.1485C>T	c.(1483-1485)TCC>TCT	p.S495S		NM_015425	NP_056240	O95602	RPA1_HUMAN	DNA-directed RNA polymerase I A	495					termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription initiation from RNA polymerase I promoter	DNA-directed RNA polymerase I complex|nucleoplasm	DNA binding|DNA-directed RNA polymerase activity|protein binding|zinc ion binding			ovary(2)|skin(1)	3						TGATGACCATGGAGGCTCCTG	0.602		NA											20	6					0	0	0	0
AFF3	3899	broad.mit.edu	37	2	100266105	100266105	+	Silent	SNP	G	G	A			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr2:100266105G>A	uc002tag.2	-	12	1403	c.1167C>T	c.(1165-1167)CTC>CTT	p.L389L	AFF3_uc002taf.2_Silent_p.L414L|AFF3_uc010fiq.1_Silent_p.L389L|AFF3_uc010yvr.1_Silent_p.L542L|AFF3_uc002tah.1_Silent_p.L414L	NM_002285	NP_002276	P51826	AFF3_HUMAN	AF4/FMR2 family, member 3 isoform 1	389					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(2)|pancreas(1)|lung(1)|kidney(1)|skin(1)	6						AGAGAGCGCGGAGAGCCGTTC	0.363		NA											8	76					0	0	0	0
FOXD4L1	200350	broad.mit.edu	37	2	114257406	114257406	+	Silent	SNP	C	C	T			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr2:114257406C>T	uc002tjw.3	+	1	746	c.573C>T	c.(571-573)TTC>TTT	p.F191F		NM_012184	NP_036316	Q9NU39	FX4L1_HUMAN	forkhead box D4-like 1	191	Fork-head.				axon extension involved in axon guidance|cartilage development|dichotomous subdivision of terminal units involved in ureteric bud branching|embryo development|enteric nervous system development|iridophore differentiation|lateral line nerve glial cell development|melanocyte differentiation|neural crest cell migration|pattern specification process|peripheral nervous system development|positive regulation of BMP signaling pathway|positive regulation of kidney development|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity|sympathetic nervous system development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding				0						AGGACATGTTCGACAATGGCA	0.652		NA											13	180					0	0	0	0
TMEM177	80775	broad.mit.edu	37	2	120439145	120439145	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr2:120439145C>G	uc010flg.1	+	2	1189	c.716C>G	c.(715-717)TCT>TGT	p.S239C	TMEM177_uc002tme.2_Intron|TMEM177_uc002tmc.1_Missense_Mutation_p.S239C|TMEM177_uc002tmd.2_Missense_Mutation_p.S239C|TMEM177_uc010flh.2_Intron	NM_001105198	NP_001098668	Q53S58	TM177_HUMAN	transmembrane protein 177	239						integral to membrane				ovary(1)	1	Colorectal(110;0.196)					GCCTCCCTCTCTGCAGCCTAT	0.607		NA											16	33					0	0	0	0
NEB	4703	broad.mit.edu	37	2	152398055	152398055	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr2:152398055C>T	uc010fnx.2	-	108	15676	c.15485G>A	c.(15484-15486)AGA>AAA	p.R5162K	NEB_uc002txr.2_Missense_Mutation_p.R1585K	NM_004543	NP_004534	P20929	NEBU_HUMAN	nebulin isoform 3	5162	Nebulin 140.				muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			ovary(8)|large_intestine(5)|breast(3)|central_nervous_system(2)|skin(1)|pancreas(1)	20				BRCA - Breast invasive adenocarcinoma(221;0.219)		GCCTGCAGCTCTGTAGACCAG	0.358		NA											7	90					0	0	0	0
BAZ2B	29994	broad.mit.edu	37	2	160194092	160194092	+	Silent	SNP	C	C	T			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr2:160194092C>T	uc002uao.2	-	32	5998	c.5646G>A	c.(5644-5646)CGG>CGA	p.R1882R	BAZ2B_uc002uap.2_Silent_p.R1846R	NM_013450	NP_038478	Q9UIF8	BAZ2B_HUMAN	bromodomain adjacent to zinc finger domain, 2B	1882					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(3)|skin(1)	4						TTTCAATGTTCCGCTCCAAAT	0.488		NA											37	84					0	0	0	0
XIRP2	129446	broad.mit.edu	37	2	168107133	168107133	+	Missense_Mutation	SNP	G	G	T			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr2:168107133G>T	uc002udx.2	+	8	9249	c.9231G>T	c.(9229-9231)GAG>GAT	p.E3077D	XIRP2_uc010fpn.2_Intron|XIRP2_uc010fpo.2_Intron|XIRP2_uc010fpp.2_Intron|XIRP2_uc002udy.2_Missense_Mutation_p.E2902D|XIRP2_uc010fpq.2_Missense_Mutation_p.E2855D|XIRP2_uc010fpr.2_Intron	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	2902					actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14						TTGCCAAAGAGAAAACAGTAC	0.353		NA											55	18					1.28e-28	1.38e-28	1	0
ZAK	51776	broad.mit.edu	37	2	174131080	174131080	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr2:174131080G>C	uc002uhz.2	+	20	2205	c.2005G>C	c.(2005-2007)GAG>CAG	p.E669Q	uc002uib.2_Intron	NM_016653	NP_057737	Q9NYL2	MLTK_HUMAN	MLK-related kinase isoform 1	669					activation of JUN kinase activity|activation of MAPKK activity|cell cycle arrest|cell death|cell differentiation|cell proliferation|DNA damage checkpoint|positive regulation of apoptosis|response to radiation	cytoplasm|nucleus	ATP binding|identical protein binding|magnesium ion binding|MAP kinase kinase kinase activity|protein binding			lung(3)|stomach(1)|ovary(1)|skin(1)	6			OV - Ovarian serous cystadenocarcinoma(117;0.176)			CACCTCTTCAGAGAGGGGTCG	0.458		NA											17	61					0	0	0	0
TTN	7273	broad.mit.edu	37	2	179413442	179413442	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr2:179413442C>G	uc010zfg.1	-	288	85431	c.85207G>C	c.(85207-85209)GAT>CAT	p.D28403H	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.D22098H|TTN_uc010zfi.1_Missense_Mutation_p.D22031H|TTN_uc010zfj.1_Missense_Mutation_p.D21906H	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	29330							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GTATGGATATCAGCCCGAAGG	0.478		NA											5	73					0	0	0	0
TRAK2	66008	broad.mit.edu	37	2	202285154	202285154	+	Missense_Mutation	SNP	G	G	A	rs146913241	byFrequency	TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr2:202285154G>A	uc002uyb.3	-	2	523	c.77C>T	c.(76-78)TCG>TTG	p.S26L	TRAK2_uc002uyc.2_Missense_Mutation_p.S26L	NM_015049	NP_055864	O60296	TRAK2_HUMAN	trafficking protein, kinesin binding 2	26						early endosome|plasma membrane	GABA receptor binding				0						GATGCTCTCCGAGTCTCTGTG	0.398		NA											11	88					0	0	0	0
ILKAP	80895	broad.mit.edu	37	2	239079271	239079271	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr2:239079271C>T	uc002vxv.2	-	12	1215	c.1085G>A	c.(1084-1086)CGC>CAC	p.R362H	ILKAP_uc010zns.1_Missense_Mutation_p.R294H|ILKAP_uc002vxw.2_Missense_Mutation_p.R242H	NM_030768	NP_110395	Q9H0C8	ILKAP_HUMAN	integrin-linked kinase-associated protein	362	PP2C-like.					cytoplasm|protein serine/threonine phosphatase complex	metal ion binding|protein binding			ovary(3)	3		Breast(86;7.61e-05)|Renal(207;0.00183)|Ovarian(221;0.0481)|all_lung(227;0.152)|all_hematologic(139;0.158)|Melanoma(123;0.203)|Hepatocellular(293;0.244)		Epithelial(121;5.49e-24)|OV - Ovarian serous cystadenocarcinoma(60;3.93e-12)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;6.82e-08)|BRCA - Breast invasive adenocarcinoma(100;0.00012)|Lung(119;0.00942)|LUSC - Lung squamous cell carcinoma(224;0.0163)		TGCTTCGTAGCGGGCGTCGGC	0.612		NA											20	27					0	0	0	0
SIRPD	128646	broad.mit.edu	37	20	1517864	1517864	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr20:1517864C>G	uc002wfi.2	-	3	558	c.514G>C	c.(514-516)GAG>CAG	p.E172Q		NM_178460	NP_848555	Q9H106	SIRPD_HUMAN	signal-regulatory protein delta precursor	172						extracellular region				ovary(1)|kidney(1)|skin(1)	3						CTGTTTCTCTCAGGCAGGGCC	0.602		NA											5	83					0	0	0	0
SLC4A11	83959	broad.mit.edu	37	20	3210904	3210904	+	Missense_Mutation	SNP	G	G	A	rs121909388		TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr20:3210904G>A	uc002wig.2	-	12	1514	c.1466C>T	c.(1465-1467)TCG>TTG	p.S489L	SLC4A11_uc010zqe.1_Missense_Mutation_p.S516L|SLC4A11_uc002wih.2_RNA|SLC4A11_uc010zqf.1_Missense_Mutation_p.S473L	NM_032034	NP_114423	Q8NBS3	S4A11_HUMAN	solute carrier family 4 member 11	489	Membrane (bicarbonate transporter).		S -> L (in CHED2; affects protein processing and transport to the cell surface).		cellular cation homeostasis|fluid transport|phosphoenolpyruvate-dependent sugar phosphotransferase system	basolateral plasma membrane|integral to membrane	bicarbonate transmembrane transporter activity|borate transmembrane transporter activity|hydrogen ion channel activity|inorganic anion exchanger activity|sodium channel activity|sugar:hydrogen symporter activity			ovary(1)	1						CTCCTCCGTCGACCTGCCAGG	0.637		NA											14	20					0	0	0	0
NKX2-2	4821	broad.mit.edu	37	20	21494272	21494272	+	Silent	SNP	G	G	A			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr20:21494272G>A	uc002wsi.2	-	1	393	c.36C>T	c.(34-36)GTC>GTT	p.V12V		NM_002509	NP_002500	O95096	NKX22_HUMAN	NK2 transcription factor related, locus 2	12					brain development|positive regulation of sequence-specific DNA binding transcription factor activity	nucleus	chromatin binding|core promoter proximal region DNA binding|transcription coactivator activity			pancreas(1)|skin(1)	2						AGATGTCCTTGACCGAAAACC	0.572		NA											6	51					0	0	0	0
PLUNC	51297	broad.mit.edu	37	20	31829196	31829196	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr20:31829196G>A	uc002wyv.2	+	6	657	c.587G>A	c.(586-588)GGC>GAC	p.G196D	PLUNC_uc002wyt.3_Missense_Mutation_p.G196D|PLUNC_uc002wyu.3_Missense_Mutation_p.G196D	NM_130852	NP_570913	Q9NP55	PLUNC_HUMAN	palate, lung and nasal epithelium associated	196					innate immune response	extracellular region	lipid binding				0						TTCAGACTTGGCCCCCTCCCC	0.542		NA											97	165					0	0	0	0
EIF2S2	8894	broad.mit.edu	37	20	32677564	32677564	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr20:32677564C>T	uc002xaf.2	-	9	1143	c.974G>A	c.(973-975)CGA>CAA	p.R325Q	EIF2S2_uc002xag.2_Missense_Mutation_p.R322Q|EIF2S2_uc010ges.2_Missense_Mutation_p.R265Q	NM_003908	NP_003899	P20042	IF2B_HUMAN	eukaryotic translation initiation factor 2 beta	325						cytosol|eukaryotic translation initiation factor 2 complex	metal ion binding|protein binding|translation initiation factor activity			large_intestine(1)	1						GAGCTGTGCTCGCTTGCCCGT	0.473		NA											23	40					0	0	0	0
LBP	3929	broad.mit.edu	37	20	36993299	36993299	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr20:36993299G>A	uc002xic.1	+	8	849	c.814G>A	c.(814-816)GAA>AAA	p.E272K		NM_004139	NP_004130	P18428	LBP_HUMAN	lipopolysaccharide-binding protein precursor	272					acute-phase response|cellular defense response|cellular response to lipoteichoic acid|defense response to Gram-negative bacterium|defense response to Gram-positive bacterium|detection of molecule of bacterial origin|innate immune response|lipid transport|lipopolysaccharide transport|lipopolysaccharide-mediated signaling pathway|macrophage activation involved in immune response|negative regulation of tumor necrosis factor production|opsonization|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of macrophage activation|positive regulation of respiratory burst involved in inflammatory response|positive regulation of toll-like receptor 4 signaling pathway|positive regulation of tumor necrosis factor production|Toll signaling pathway	extracellular space	Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|lipid binding|lipopolysaccharide binding|lipoteichoic acid binding|receptor binding			ovary(1)|central_nervous_system(1)	2		Myeloproliferative disorder(115;0.00878)				CCTTCCTGAGGAACACAACAA	0.468		NA											45	84					0	0	0	0
CHD6	84181	broad.mit.edu	37	20	40050616	40050616	+	Silent	SNP	G	G	C			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr20:40050616G>C	uc002xka.1	-	31	4837	c.4659C>G	c.(4657-4659)CTC>CTG	p.L1553L		NM_032221	NP_115597	Q8TD26	CHD6_HUMAN	chromodomain helicase DNA binding protein 6	1553					chromatin remodeling|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding			ovary(6)|skin(5)|lung(2)|central_nervous_system(1)	14		Myeloproliferative disorder(115;0.00425)				GAGGGCACTTGAGCACTTGCT	0.562		NA											14	39					0	0	0	0
RBPJL	11317	broad.mit.edu	37	20	43942191	43942191	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr20:43942191G>C	uc002xns.2	+	7	775	c.703G>C	c.(703-705)GAT>CAT	p.D235H	RBPJL_uc002xnt.2_Missense_Mutation_p.D235H	NM_014276	NP_055091	Q9UBG7	RBPJL_HUMAN	recombining binding protein L	235					signal transduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1		Myeloproliferative disorder(115;0.0122)				CTCTGTGGAGGATGGGGCCTT	0.453		NA											7	15					0	0	0	0
ZNF335	63925	broad.mit.edu	37	20	44577711	44577711	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr20:44577711C>G	uc002xqw.2	-	28	4033	c.3910G>C	c.(3910-3912)GAT>CAT	p.D1304H	ZNF335_uc002xqv.2_Missense_Mutation_p.D416H|ZNF335_uc010zxk.1_Missense_Mutation_p.D1149H	NM_022095	NP_071378	Q9H4Z2	ZN335_HUMAN	zinc finger protein 335	1304	Gln-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(3)|ovary(1)	4		Myeloproliferative disorder(115;0.0122)				ATGGCAGCATCAGCCACTGCT	0.597		NA											6	32					0	0	0	0
CD40	958	broad.mit.edu	37	20	44757575	44757575	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr20:44757575G>C	uc002xrg.1	+	9	807	c.730G>C	c.(730-732)GGC>CGC	p.G244R	CD40_uc002xrh.1_3'UTR|CD40_uc002xri.1_3'UTR|CD40_uc002xrj.1_RNA|CD40_uc002xrk.1_RNA|CD40_uc002xrl.1_RNA	NM_001250	NP_001241	P25942	TNR5_HUMAN	CD40 antigen isoform 1 precursor	244	Cytoplasmic (Potential).				B cell proliferation|cellular response to mechanical stimulus|inflammatory response|platelet activation|positive regulation of endothelial cell apoptosis|positive regulation of I-kappaB kinase/NF-kappaB cascade|protein complex assembly	CD40 receptor complex|extracellular region	enzyme binding|receptor activity			lung(1)|skin(1)	2		Myeloproliferative disorder(115;0.0122)			Simvastatin(DB00641)	CGATCTTCCTGGCTCCAACAC	0.597		NA							Immune_Deficiency_with_Hyper-IgM		OREG0025991	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	17	28					0	0	0	0
ARFGEF2	10564	broad.mit.edu	37	20	47633821	47633821	+	Silent	SNP	T	T	C			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr20:47633821T>C	uc002xtx.3	+	32	4503	c.4351T>C	c.(4351-4353)TTA>CTA	p.L1451L	ARFGEF2_uc010zyf.1_Silent_p.L744L	NM_006420	NP_006411	Q9Y6D5	BIG2_HUMAN	ADP-ribosylation factor guanine	1451					exocytosis|intracellular signal transduction|regulation of ARF protein signal transduction	cytosol|Golgi membrane	ARF guanyl-nucleotide exchange factor activity			breast(3)|upper_aerodigestive_tract(1)	4			BRCA - Breast invasive adenocarcinoma(12;0.00148)|Colorectal(8;0.198)			TACAAATTGCTTAGAAAACTT	0.368		NA											23	32					0	0	0	0
ZNF217	7764	broad.mit.edu	37	20	52198233	52198233	+	Missense_Mutation	SNP	G	G	T			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr20:52198233G>T	uc002xwq.3	-	1	1404	c.1133C>A	c.(1132-1134)TCC>TAC	p.S378Y	ZNF217_uc010gij.1_Missense_Mutation_p.S370Y	NM_006526	NP_006517	O75362	ZN217_HUMAN	zinc finger protein 217	378	C2H2-type 5.				negative regulation of transcription, DNA-dependent	histone deacetylase complex	protein binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			skin(2)|ovary(1)|large_intestine(1)|lung(1)|breast(1)	6	all_cancers(1;6.75e-17)|all_epithelial(1;1.76e-18)|Breast(2;3.83e-14)|Lung NSC(4;9.04e-07)|all_lung(4;2.5e-06)|Ovarian(1;0.0398)		BRCA - Breast invasive adenocarcinoma(1;9.88e-17)|Epithelial(1;1.56e-14)|all cancers(1;9.44e-13)|STAD - Stomach adenocarcinoma(23;0.0474)|Colorectal(105;0.198)			GCCGCACTCGGAGCAGTGAGT	0.607		NA											6	57					0.00198382	0.00202778	1	0
KRTAP27-1	643812	broad.mit.edu	37	21	31709900	31709900	+	Silent	SNP	G	G	T			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr21:31709900G>T	uc002ynx.1	-	1	113	c.87C>A	c.(85-87)ACC>ACA	p.T29T		NM_001077711	NP_001071179	Q3LI81	KR271_HUMAN	keratin associated protein 27-1	29						intermediate filament				ovary(2)	2						TGTCTTCAAAGGTTATAGGAT	0.468		NA											44	99					7.05e-23	7.56e-23	1	0
MRAP	56246	broad.mit.edu	37	21	33686872	33686872	+	Missense_Mutation	SNP	G	G	T	rs150983600		TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr21:33686872G>T	uc002ypk.2	+	5	404	c.217G>T	c.(217-219)GAT>TAT	p.D73Y	URB1_uc002ypn.2_3'UTR	NM_206898	NP_996781	Q8TCY5	MRAP_HUMAN	melanocortin 2 receptor accessory protein	Error:Variant_position_missing_in_Q8TCY5_after_alignment					positive regulation of cAMP biosynthetic process|protein localization at cell surface	endoplasmic reticulum|integral to membrane|perinuclear region of cytoplasm|plasma membrane	corticotropin hormone receptor binding|type 1 melanocortin receptor binding|type 3 melanocortin receptor binding|type 4 melanocortin receptor binding|type 5 melanocortin receptor binding				0						CTTTAACACAGATGAATCTCT	0.378		NA											23	28					3.29e-13	3.48e-13	1	0
ZNF295	49854	broad.mit.edu	37	21	43412300	43412300	+	Silent	SNP	C	C	G			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr21:43412300C>G	uc002zab.3	-	3	2119	c.1905G>C	c.(1903-1905)CTG>CTC	p.L635L	ZNF295_uc002yzz.3_Intron|ZNF295_uc002yzy.3_Silent_p.L635L|ZNF295_uc002zaa.3_Silent_p.L635L	NM_001098402	NP_001091872	Q9ULJ3	ZN295_HUMAN	zinc finger protein 295 isoform L	635					negative regulation of transcription, DNA-dependent|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|nucleus	methyl-CpG binding|protein binding|zinc ion binding			ovary(1)|central_nervous_system(1)|skin(1)	3						ACTTAATGATCAGGGCCTTCT	0.458		NA											4	81					0	0	0	0
TMPRSS3	64699	broad.mit.edu	37	21	43795836	43795836	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr21:43795836C>T	uc002zbb.2	-	12	1537	c.1336G>A	c.(1336-1338)GAG>AAG	p.E446K	TMPRSS3_uc002zay.2_Missense_Mutation_p.E203K|TMPRSS3_uc002zaz.2_Missense_Mutation_p.E319K|TMPRSS3_uc002zba.2_Missense_Mutation_p.E319K|TMPRSS3_uc002zbc.2_Missense_Mutation_p.E445K	NM_024022	NP_076927	P57727	TMPS3_HUMAN	transmembrane protease, serine 3 isoform 1	446	Peptidase S1.|Extracellular (Potential).				cellular sodium ion homeostasis|proteolysis	endoplasmic reticulum membrane|integral to membrane	scavenger receptor activity|serine-type endopeptidase activity|sodium channel regulator activity			ovary(2)|breast(1)	3						TCCATCTGCTCGTGGATCCAG	0.582		NA											37	78					0	0	0	0
ATP6V1E1	529	broad.mit.edu	37	22	18083871	18083871	+	Missense_Mutation	SNP	C	C	A			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr22:18083871C>A	uc002zmr.1	-	5	540	c.353G>T	c.(352-354)GGA>GTA	p.G118V	ATP6V1E1_uc002zms.1_Intron|ATP6V1E1_uc002zmt.1_Missense_Mutation_p.G96V	NM_001696	NP_001687	P36543	VATE1_HUMAN	vacuolar H+ ATPase E1 isoform a	118					cellular iron ion homeostasis|insulin receptor signaling pathway|transferrin transport	apical plasma membrane|cytosol|endosome|proton-transporting two-sector ATPase complex, catalytic domain	protein binding|proton-transporting ATPase activity, rotational mechanism			large_intestine(1)|central_nervous_system(1)	2		all_epithelial(15;0.206)		Lung(27;0.19)		GAGAACCAGTCCATCCAGCAG	0.393		NA											41	69					3.05e-18	3.25e-18	1	0
SF3A1	10291	broad.mit.edu	37	22	30730681	30730681	+	Missense_Mutation	SNP	T	T	C			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr22:30730681T>C	uc003ahl.2	-	16	2416	c.2284A>G	c.(2284-2286)ATC>GTC	p.I762V		NM_005877	NP_005868	Q15459	SF3A1_HUMAN	splicing factor 3a, subunit 1, 120kDa isoform 1	762	Ubiquitin-like.				nuclear mRNA 3'-splice site recognition	catalytic step 2 spliceosome|nucleoplasm|U2-type spliceosomal complex	protein binding|RNA binding			ovary(3)|large_intestine(1)|pancreas(1)	5						TTGATGAAGATACCCTGGAAA	0.537		NA											26	46					0	0	0	0
CSF2RB	1439	broad.mit.edu	37	22	37334191	37334191	+	Missense_Mutation	SNP	A	A	T			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr22:37334191A>T	uc003aqa.3	+	14	2558	c.2341A>T	c.(2341-2343)AGG>TGG	p.R781W	CSF2RB_uc003aqc.3_Missense_Mutation_p.R787W	NM_000395	NP_000386	P32927	IL3RB_HUMAN	colony stimulating factor 2 receptor, beta	781	Cytoplasmic (Potential).				respiratory gaseous exchange	granulocyte macrophage colony-stimulating factor receptor complex	cytokine receptor activity			skin(2)|pancreas(1)	3					Sargramostim(DB00020)	CAGGTCACCAAGGAACAATCC	0.652		NA											15	32					0	0	0	0
WNT7B	7477	broad.mit.edu	37	22	46319005	46319005	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr22:46319005G>C	uc003bgo.2	-	4	1155	c.781C>G	c.(781-783)CAG>GAG	p.Q261E	WNT7B_uc010haa.2_Missense_Mutation_p.Q265E	NM_058238	NP_478679	P56706	WNT7B_HUMAN	wingless-type MMTV integration site family,	261					activation of JUN kinase activity|anterior/posterior pattern formation|axis specification|axonogenesis|canonical Wnt receptor signaling pathway|cell-cell signaling|cellular response to retinoic acid|central nervous system vasculogenesis|chorio-allantoic fusion|developmental growth involved in morphogenesis|embryonic placenta morphogenesis|establishment or maintenance of polarity of embryonic epithelium|fibroblast proliferation|forebrain regionalization|inner medullary collecting duct development|lens fiber cell development|lobar bronchus development|lung epithelium development|lung morphogenesis|lung-associated mesenchyme development|mammary gland epithelium development|metanephric collecting duct development|metanephric loop of Henle development|metanephros morphogenesis|negative regulation of smoothened signaling pathway|outer medullary collecting duct development|oxygen homeostasis|positive regulation of JNK cascade|positive regulation of osteoblast differentiation|renal inner medulla development|renal outer medulla development|stem cell proliferation|synapse organization|trachea cartilage morphogenesis|Wnt receptor signaling pathway, calcium modulating pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	extracellular matrix structural constituent|frizzled binding|signal transducer activity			lung(1)	1		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0178)|LUAD - Lung adenocarcinoma(64;0.247)		ATGGGCTTCTGATAGCTGCGC	0.647		NA											7	62					0	0	0	0
BRPF1	7862	broad.mit.edu	37	3	9786777	9786777	+	Silent	SNP	G	G	C			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr3:9786777G>C	uc003bse.2	+	10	3387	c.2988G>C	c.(2986-2988)CGG>CGC	p.R996R	BRPF1_uc003bsf.2_Silent_p.R1002R|BRPF1_uc003bsg.2_Silent_p.R995R|BRPF1_uc011ati.1_Silent_p.R901R	NM_004634	NP_004625	P55201	BRPF1_HUMAN	bromodomain and PHD finger-containing protein 1	996	Required for RUNX1 and RUNX2 transcriptional activation.				histone H3 acetylation|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|MOZ/MORF histone acetyltransferase complex|plasma membrane	DNA binding|zinc ion binding			ovary(2)|central_nervous_system(1)	3	Medulloblastoma(99;0.227)					GCCTTCCCCGGAGCAGCTCAG	0.557		NA											11	18					0	0	0	0
SLC6A1	6529	broad.mit.edu	37	3	11072889	11072889	+	Silent	SNP	T	T	C			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr3:11072889T>C	uc010hdq.2	+	13	1761	c.1350T>C	c.(1348-1350)TTT>TTC	p.F450F		NM_003042	NP_003033	P30531	SC6A1_HUMAN	solute carrier family 6 (neurotransmitter	450					neurotransmitter secretion	integral to plasma membrane	gamma-aminobutyric acid:sodium symporter activity|neurotransmitter:sodium symporter activity			ovary(1)|skin(1)	2		Ovarian(110;0.0392)		OV - Ovarian serous cystadenocarcinoma(96;0.00099)	Cocaine(DB00907)|Tiagabine(DB00906)	TCAAACTCTTTGACTACTACT	0.498		NA											25	95					0	0	0	0
C3orf20	84077	broad.mit.edu	37	3	14799082	14799082	+	Silent	SNP	C	C	T			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr3:14799082C>T	uc003byy.2	+	13	2549	c.2145C>T	c.(2143-2145)ATC>ATT	p.I715I	C3orf20_uc003byz.2_Silent_p.I593I|C3orf20_uc003bza.2_Silent_p.I593I|C3orf20_uc003bzb.1_Silent_p.I216I|C3orf20_uc011avj.1_Silent_p.I42I	NM_032137	NP_115513	Q8ND61	CC020_HUMAN	hypothetical protein LOC84077	715						cytoplasm|integral to membrane				ovary(3)|skin(1)	4						TGTTTGGGATCATCTCAAGCC	0.637		NA											4	28					0	0	0	0
KAT2B	8850	broad.mit.edu	37	3	20181763	20181763	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr3:20181763C>G	uc003cbq.2	+	13	2357	c.1911C>G	c.(1909-1911)ATC>ATG	p.I637M		NM_003884	NP_003875	Q92831	KAT2B_HUMAN	K(lysine) acetyltransferase 2B	637	N-acetyltransferase.				cell cycle arrest|cellular response to insulin stimulus|chromatin remodeling|histone H3 acetylation|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|negative regulation of cell proliferation|transcription initiation from RNA polymerase I promoter	Ada2/Gcn5/Ada3 transcription activator complex|chromatin remodeling complex|PCAF complex	cyclin-dependent protein kinase inhibitor activity|histone acetyltransferase activity|histone deacetylase binding|protein kinase binding|transcription coactivator activity|transcription factor binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3						TTGGCTATATCAAGGATTATG	0.328		NA											5	44					0	0	0	0
SCN11A	11280	broad.mit.edu	37	3	38888469	38888469	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr3:38888469C>G	uc011ays.1	-	26	5291	c.5092G>C	c.(5092-5094)GAT>CAT	p.D1698H		NM_014139	NP_054858	Q9UI33	SCNBA_HUMAN	sodium channel, voltage-gated, type XI, alpha	1698					response to drug	voltage-gated sodium channel complex	voltage-gated sodium channel activity			skin(6)|ovary(1)|haematopoietic_and_lymphoid_tissue(1)|pancreas(1)	9				Kidney(284;0.00202)|KIRC - Kidney renal clear cell carcinoma(284;0.00226)	Cocaine(DB00907)	TCTAGGCCATCAGAGCCACCG	0.453		NA											4	74					0	0	0	0
SCN11A	11280	broad.mit.edu	37	3	38941542	38941542	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr3:38941542G>C	uc011ays.1	-	13	2064	c.1865C>G	c.(1864-1866)GCA>GGA	p.A622G		NM_014139	NP_054858	Q9UI33	SCNBA_HUMAN	sodium channel, voltage-gated, type XI, alpha	622	II.|Helical; Name=S2 of repeat II; (By similarity).				response to drug	voltage-gated sodium channel complex	voltage-gated sodium channel activity			skin(6)|ovary(1)|haematopoietic_and_lymphoid_tissue(1)|pancreas(1)	9				Kidney(284;0.00202)|KIRC - Kidney renal clear cell carcinoma(284;0.00226)	Cocaine(DB00907)	GCACATTTCTGCTATAAAAAT	0.428		NA											3	19					0	0	0	0
XCR1	2829	broad.mit.edu	37	3	46062824	46062824	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr3:46062824C>T	uc003cpe.2	-	3	840	c.616G>A	c.(616-618)GTG>ATG	p.V206M	uc003cpd.1_5'Flank|XCR1_uc003cpf.2_Missense_Mutation_p.V206M	NM_005283	NP_005274	P46094	XCR1_HUMAN	XC chemokine receptor 1	206	Helical; Name=5; (Potential).				chemotaxis|G-protein signaling, coupled to cyclic nucleotide second messenger|inflammatory response	integral to plasma membrane	chemokine receptor activity			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.00113)|KIRC - Kidney renal clear cell carcinoma(197;0.0172)|Kidney(197;0.0203)		AGGATCTCCACGTAGCAGAAC	0.587		NA											9	12					0	0	0	0
BSN	8927	broad.mit.edu	37	3	49699342	49699342	+	Nonsense_Mutation	SNP	C	C	G			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr3:49699342C>G	uc003cxe.3	+	6	10178	c.10064C>G	c.(10063-10065)TCA>TGA	p.S3355*		NM_003458	NP_003449	Q9UPA5	BSN_HUMAN	bassoon protein	3355					synaptic transmission	cell junction|cytoplasm|cytoskeleton|nucleus|synaptosome	metal ion binding			ovary(5)|pancreas(1)|central_nervous_system(1)|skin(1)	8				BRCA - Breast invasive adenocarcinoma(193;6.66e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.0032)|Kidney(197;0.00336)		GCCATCTCCTCAAAGCGCAGC	0.572		NA											3	29					0	0	0	0
TEX264	51368	broad.mit.edu	37	3	51708516	51708516	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr3:51708516G>C	uc010hls.2	+	3	365	c.196G>C	c.(196-198)GAG>CAG	p.E66Q	TEX264_uc003dbk.3_Missense_Mutation_p.E66Q|TEX264_uc010hlt.2_Intron|TEX264_uc003dbl.3_Missense_Mutation_p.E66Q|TEX264_uc003dbm.3_Missense_Mutation_p.E105Q	NM_001129884	NP_001123356	Q9Y6I9	TX264_HUMAN	testis expressed 264 precursor	66						extracellular region					0				BRCA - Breast invasive adenocarcinoma(193;8.53e-05)|Kidney(197;0.000594)|KIRC - Kidney renal clear cell carcinoma(197;0.000759)		GCTTTTCACTGAGAGCTGCAG	0.587		NA											4	39					0	0	0	0
RYBP	23429	broad.mit.edu	37	3	72428559	72428559	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr3:72428559G>A	uc003dpe.2	-	2	265	c.148C>T	c.(148-150)CAG>TAG	p.Q50*		NM_012234	NP_036366	Q8N488	RYBP_HUMAN	RING1 and YY1 binding protein	60					apoptosis|histone H2A monoubiquitination|multicellular organismal development|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|nucleoplasm	DNA binding|protein binding|transcription corepressor activity|zinc ion binding				0		Prostate(10;0.00174)|Lung NSC(201;0.0659)|Myeloproliferative disorder(1037;0.204)		BRCA - Breast invasive adenocarcinoma(55;0.000197)|Epithelial(33;0.00068)|LUSC - Lung squamous cell carcinoma(21;0.00228)|Lung(16;0.00677)|KIRC - Kidney renal clear cell carcinoma(39;0.198)|Kidney(39;0.232)		GCCACCAGCTGAGAATTGATC	0.388		NA											16	18					0	0	0	0
DPPA2	151871	broad.mit.edu	37	3	109028157	109028157	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr3:109028157C>T	uc003dxo.2	-	4	449	c.202G>A	c.(202-204)GAG>AAG	p.E68K		NM_138815	NP_620170	Q7Z7J5	DPPA2_HUMAN	developmental pluripotency associated 2	68						nucleus	nucleic acid binding			ovary(2)|upper_aerodigestive_tract(1)	3						GTAAATTGCTCATTTGTTTGA	0.363		NA											5	112					0	0	0	0
MUC13	56667	broad.mit.edu	37	3	124646819	124646819	+	Nonsense_Mutation	SNP	G	G	C			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr3:124646819G>C	uc003ehq.1	-	2	95	c.71C>G	c.(70-72)TCA>TGA	p.S24*		NM_033049	NP_149038	Q9H3R2	MUC13_HUMAN	mucin 13, epithelial transmembrane	24	Extracellular (Potential).					extracellular region|integral to membrane|plasma membrane					0						AGCATCAGCTGAGTTGCCTTG	0.428		NA											5	110					0	0	0	0
MSL2	55167	broad.mit.edu	37	3	135870295	135870295	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr3:135870295G>C	uc003eqx.1	-	2	2161	c.1428C>G	c.(1426-1428)TGC>TGG	p.C476W	MSL2_uc011bmb.1_Missense_Mutation_p.C402W	NM_018133	NP_060603	Q9HCI7	MSL2_HUMAN	ring finger protein 184 isoform 1	476					histone H4-K16 acetylation	MSL complex	zinc ion binding			central_nervous_system(1)	1						GTTGGCCTCGGCATGTAAGAA	0.478		NA											21	48					0	0	0	0
A4GNT	51146	broad.mit.edu	37	3	137850006	137850006	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr3:137850006G>C	uc003ers.2	-	2	295	c.93C>G	c.(91-93)TTC>TTG	p.F31L		NM_016161	NP_057245	Q9UNA3	A4GCT_HUMAN	alpha-1,4-N-acetylglucosaminyltransferase	31	Lumenal (Potential).				protein O-linked glycosylation	Golgi membrane|Golgi stack|integral to membrane|membrane fraction	acetylglucosaminyltransferase activity|galactosyltransferase activity			central_nervous_system(1)	1						AAGGCAAACAGAAGAGGCAGC	0.562		NA											5	90					0	0	0	0
COPB2	9276	broad.mit.edu	37	3	139093347	139093347	+	Silent	SNP	G	G	A			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr3:139093347G>A	uc003etf.3	-	7	865	c.735C>T	c.(733-735)ATC>ATT	p.I245I	COPB2_uc011bmv.1_Silent_p.I216I|COPB2_uc010hui.2_Silent_p.I216I|COPB2_uc011bmw.1_Silent_p.I245I	NM_004766	NP_004757	P35606	COPB2_HUMAN	coatomer protein complex, subunit beta 2 (beta	245	WD 6.				COPI coating of Golgi vesicle|intra-Golgi vesicle-mediated transport|intracellular protein transport|retrograde vesicle-mediated transport, Golgi to ER	COPI vesicle coat|cytosol	protein binding|structural molecule activity			ovary(2)	2						CTGAACCTGTGATAATGATTG	0.388		NA											33	72					0	0	0	0
PTX3	5806	broad.mit.edu	37	3	157160376	157160376	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr3:157160376G>C	uc003fbl.3	+	3	897	c.754G>C	c.(754-756)GAG>CAG	p.E252Q	VEPH1_uc003fbj.1_Intron|VEPH1_uc003fbk.1_Intron|VEPH1_uc010hvu.1_Intron	NM_002852	NP_002843	P26022	PTX3_HUMAN	pentraxin 3 precursor	252	Pentaxin.				inflammatory response	extracellular region				central_nervous_system(1)	1			Lung(72;0.0272)|LUSC - Lung squamous cell carcinoma(72;0.0461)			GGTGGGTGGAGAGGAGAACAA	0.488		NA											39	78					0	0	0	0
SI	6476	broad.mit.edu	37	3	164785231	164785231	+	Missense_Mutation	SNP	T	T	G			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr3:164785231T>G	uc003fei.2	-	6	594	c.532A>C	c.(532-534)AAA>CAA	p.K178Q		NM_001041	NP_001032	P14410	SUIS_HUMAN	sucrase-isomaltase	178	Lumenal.|Isomaltase.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			ovary(7)|upper_aerodigestive_tract(4)|skin(2)|pancreas(1)	14		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	GTAAACTCTTTTACATACTGA	0.343		NA								HNSCC(35;0.089)			33	79					0	0	0	0
PRKCI	5584	broad.mit.edu	37	3	170011198	170011198	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr3:170011198G>C	uc003fgs.2	+	14	1557	c.1319G>C	c.(1318-1320)GGA>GCA	p.G440A	PRKCI_uc003fgt.2_5'UTR	NM_002740	NP_002731	P41743	KPCI_HUMAN	protein kinase C, iota	440	Protein kinase.				anti-apoptosis|cellular membrane organization|cellular response to insulin stimulus|establishment or maintenance of epithelial cell apical/basal polarity|intracellular signal transduction|nerve growth factor receptor signaling pathway|positive regulation of establishment of protein localization in plasma membrane|positive regulation of glucose import|protein targeting to membrane|secretion|tight junction assembly|vesicle-mediated transport	cytosol|endosome|nucleus|polarisome	ATP binding|phospholipid binding|protein binding|protein kinase C activity|zinc ion binding			lung(2)|ovary(1)|breast(1)|skin(1)	5	all_cancers(22;6.45e-23)|all_epithelial(15;8.52e-28)|all_lung(20;6.31e-17)|Lung NSC(18;2.61e-16)|Ovarian(172;0.000337)|Breast(254;0.169)		Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.197)			TGGGCTCTTGGAGTGCTCATG	0.393		NA											21	71					0	0	0	0
MCF2L2	23101	broad.mit.edu	37	3	182923993	182923993	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr3:182923993G>C	uc003fli.1	-	24	2812	c.2722C>G	c.(2722-2724)CTT>GTT	p.L908V		NM_015078	NP_055893	Q86YR7	MF2L2_HUMAN	Rho family guanine-nucleotide exchange factor	908	PH.				regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			ovary(2)|large_intestine(2)|breast(1)	5	all_cancers(143;1.26e-12)|Ovarian(172;0.0355)		all cancers(12;3.35e-44)|Epithelial(37;6.48e-38)|LUSC - Lung squamous cell carcinoma(7;7.12e-25)|Lung(8;6.39e-23)|OV - Ovarian serous cystadenocarcinoma(80;6.75e-21)			CGAATTGAAAGTGTCATCAGC	0.408		NA											8	95					0	0	0	0
EIF4A2	1974	broad.mit.edu	37	3	186504984	186504984	+	Silent	SNP	C	C	G			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr3:186504984C>G	uc003fqs.2	+	8	879	c.840C>G	c.(838-840)CTC>CTG	p.L280L	EIF4A2_uc003fqt.2_RNA|EIF4A2_uc003fqu.2_Silent_p.L281L|EIF4A2_uc003fqv.2_Silent_p.L185L|EIF4A2_uc003fqw.2_Silent_p.L185L|EIF4A2_uc011bsb.1_Silent_p.L153L|SNORA63_uc010hyw.1_5'Flank|SNORA4_uc010hyx.1_5'Flank	NM_001967	NP_001958	Q14240	IF4A2_HUMAN	eukaryotic translation initiation factor 4A2	280	Helicase C-terminal.				interspecies interaction between organisms|nuclear-transcribed mRNA poly(A) tail shortening|regulation of translational initiation	cytosol|eukaryotic translation initiation factor 4F complex	ATP binding|ATP-dependent helicase activity|protein binding|translation initiation factor activity			ovary(2)|breast(2)	4	all_cancers(143;2.68e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;1.07e-20)	GBM - Glioblastoma multiforme(93;0.0704)		TTATTTTTCTCAATACGAGGC	0.423		NA	T	BCL6	NHL								27	139					0	0	0	0
ZNF595	152687	broad.mit.edu	37	4	59346	59346	+	Silent	SNP	G	G	A			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr4:59346G>A	uc003fzv.1	+	2	183	c.27G>A	c.(25-27)GTG>GTA	p.V9V	ZNF595_uc003fzu.1_RNA|ZNF718_uc003fzt.3_Silent_p.V9V|ZNF595_uc010iay.1_RNA|ZNF595_uc011bus.1_5'UTR|ZNF595_uc011but.1_Intron	NM_182524	NP_872330	Q7Z3I0	Q7Z3I0_HUMAN	zinc finger protein 595	9					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding				0		all_cancers(4;0.0738)|all_epithelial(65;0.139)		Lung(54;0.0654)|Epithelial(2;0.0921)|all cancers(2;0.146)|LUSC - Lung squamous cell carcinoma(95;0.173)		TCAGGGATGTGGCCATAGAAT	0.413		NA											53	173					0	0	0	0
JAKMIP1	152789	broad.mit.edu	37	4	6055779	6055779	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr4:6055779C>T	uc003giu.3	-	13	2080	c.1804G>A	c.(1804-1806)GAA>AAA	p.E602K	JAKMIP1_uc010idb.1_Missense_Mutation_p.E602K|JAKMIP1_uc010idc.1_Missense_Mutation_p.E417K|JAKMIP1_uc010idd.1_Intron|JAKMIP1_uc011bwc.1_Missense_Mutation_p.E437K|JAKMIP1_uc003giv.3_Missense_Mutation_p.E602K|JAKMIP1_uc010ide.2_3'UTR	NM_144720	NP_653321	Q96N16	JKIP1_HUMAN	janus kinase and microtubule interacting protein	602	Mediates interaction with TYK2 and GABBR1.|Potential.				protein transport	cytoplasm|membrane|microtubule|peripheral to membrane of membrane fraction|ribonucleoprotein complex	GABA receptor binding|RNA binding			large_intestine(1)|pancreas(1)|ovary(1)|skin(1)	4						TCTCTTACTTCGAGTTCTAGC	0.403		NA											9	135					0	0	0	0
MAN2B2	23324	broad.mit.edu	37	4	6606982	6606982	+	Silent	SNP	G	G	A			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr4:6606982G>A	uc003gjf.1	+	11	1776	c.1740G>A	c.(1738-1740)TTG>TTA	p.L580L	MAN2B2_uc003gje.1_Silent_p.L580L|MAN2B2_uc011bwf.1_Silent_p.L529L	NM_015274	NP_056089	Q9Y2E5	MA2B2_HUMAN	mannosidase, alpha, class 2B, member 2	580					mannose metabolic process	extracellular region	alpha-mannosidase activity|carbohydrate binding|zinc ion binding			ovary(2)	2						GCAGGTACTTGGTGCCTGTGG	0.612		NA											39	7					0	0	0	0
SORCS2	57537	broad.mit.edu	37	4	7714493	7714493	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr4:7714493G>C	uc003gkb.3	+	15	1902	c.1902G>C	c.(1900-1902)TGG>TGC	p.W634C	SORCS2_uc011bwi.1_Missense_Mutation_p.W462C	NM_020777	NP_065828	Q96PQ0	SORC2_HUMAN	VPS10 domain receptor protein SORCS 2 precursor	634	Lumenal (Potential).					integral to membrane	neuropeptide receptor activity			ovary(1)|central_nervous_system(1)	2						GCTCCGATTGGGAGCTGGTCA	0.597		NA											18	20					0	0	0	0
NSUN7	79730	broad.mit.edu	37	4	40752793	40752793	+	Missense_Mutation	SNP	C	C	A			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr4:40752793C>A	uc003gvj.3	+	2	578	c.83C>A	c.(82-84)TCC>TAC	p.S28Y	NSUN7_uc003gvh.2_Missense_Mutation_p.S28Y|NSUN7_uc003gvi.3_Missense_Mutation_p.S28Y	NM_024677	NP_078953			NOL1/NOP2/Sun domain family, member 7												0						CTGCCTCTGTCCGGTGGGAAA	0.527		NA											54	52					3.68e-26	3.96e-26	1	0
FRYL	285527	broad.mit.edu	37	4	48581067	48581067	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr4:48581067G>C	uc003gyh.1	-	23	3056	c.2451C>G	c.(2449-2451)CAC>CAG	p.H817Q	FRYL_uc003gyk.2_Missense_Mutation_p.H817Q	NM_015030	NP_055845	O94915	FRYL_HUMAN	furry-like	817					regulation of transcription, DNA-dependent|transcription, DNA-dependent		protein binding			skin(1)	1						CTGTAGAGCAGTGTTTAGGAA	0.393		NA											40	62					0	0	0	0
REST	5978	broad.mit.edu	37	4	57777137	57777137	+	Silent	SNP	G	G	C			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr4:57777137G>C	uc003hch.2	+	2	680	c.333G>C	c.(331-333)CTG>CTC	p.L111L	REST_uc003hci.2_Silent_p.L111L|REST_uc003hcj.1_Silent_p.L111L|REST_uc010ihf.2_5'UTR	NM_005612	NP_005603	Q13127	REST_HUMAN	RE1-silencing transcription factor	111	Interaction with SIN3A.				cardiac muscle cell myoblast differentiation|cellular response to drug|cellular response to electrical stimulus|cellular response to glucocorticoid stimulus|histone H4 deacetylation|negative regulation by host of viral transcription|negative regulation of aldosterone biosynthetic process|negative regulation of calcium ion-dependent exocytosis|negative regulation of cell proliferation|negative regulation of cortisol biosynthetic process|negative regulation of dense core granule biogenesis|negative regulation of insulin secretion|negative regulation of mesenchymal stem cell differentiation|negative regulation of neurogenesis|negative regulation of neuron differentiation|positive regulation of apoptosis|positive regulation of caspase activity|positive regulation of transcription, DNA-dependent	cytoplasm|transcriptional repressor complex	calcium channel activity|chromatin binding|core promoter proximal region sequence-specific DNA binding|core promoter sequence-specific DNA binding|outward rectifier potassium channel activity|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|zinc ion binding			skin(5)|upper_aerodigestive_tract(1)|ovary(1)|lung(1)|central_nervous_system(1)	9	Glioma(25;0.08)|all_neural(26;0.181)					ACATGGAACTGAGAAGTTTGG	0.433		NA											19	56					0	0	0	0
ENAM	10117	broad.mit.edu	37	4	71509397	71509397	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr4:71509397G>A	uc011caw.1	+	9	2535	c.2254G>A	c.(2254-2256)GCT>ACT	p.A752T		NM_031889	NP_114095	Q9NRM1	ENAM_HUMAN	enamelin precursor	752					bone mineralization|odontogenesis	proteinaceous extracellular matrix	structural constituent of tooth enamel			ovary(3)	3			Lung(101;0.235)			TAATAATGCCGCTGGACCAGA	0.453		NA											27	38					0	0	0	0
MAPK10	5602	broad.mit.edu	37	4	87028405	87028405	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr4:87028405C>T	uc003hpq.2	-	4	404	c.337G>A	c.(337-339)GTC>ATC	p.V113I	MAPK10_uc010ikg.2_Missense_Mutation_p.V75I|MAPK10_uc003hpr.2_Missense_Mutation_p.V75I|MAPK10_uc003hps.2_Missense_Mutation_p.V113I|MAPK10_uc003hpt.2_Missense_Mutation_p.V113I|MAPK10_uc003hpu.2_Missense_Mutation_p.V113I|MAPK10_uc003hpv.2_5'UTR|MAPK10_uc010ikh.1_RNA|MAPK10_uc003hpo.2_5'UTR|MAPK10_uc011ccw.1_5'UTR|MAPK10_uc003hpp.2_5'UTR	NM_138982	NP_620448	P53779	MK10_HUMAN	mitogen-activated protein kinase 10 isoform 2	113	Protein kinase.				innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|regulation of sequence-specific DNA binding transcription factor activity|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|JUN kinase activity|MAP kinase kinase activity|protein binding			stomach(1)|breast(1)|central_nervous_system(1)	3		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.243)		OV - Ovarian serous cystadenocarcinoma(123;0.002)		TTCATGAGGACCAGCTCCCGG	0.438		NA											28	36					0	0	0	0
SLC10A6	345274	broad.mit.edu	37	4	87754557	87754557	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr4:87754557G>A	uc003hqd.2	-	2	546	c.398C>T	c.(397-399)TCC>TTC	p.S133F		NM_197965	NP_932069	Q3KNW5	SOAT_HUMAN	sodium-dependent organic anion transporter	133	Cytoplasmic (Potential).					integral to membrane|plasma membrane	bile acid:sodium symporter activity				0		Acute lymphoblastic leukemia(40;0.244)|all_hematologic(202;0.248)		OV - Ovarian serous cystadenocarcinoma(123;0.00099)		GGCCACGGTGGAACAGGTTGT	0.443		NA											19	61					0	0	0	0
ADH4	127	broad.mit.edu	37	4	100048496	100048496	+	Splice_Site	SNP	C	C	G			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr4:100048496C>G	uc003hun.2	-	7	920	c.844_splice	c.e7-1	p.K282_splice	uc003hum.1_Intron|ADH4_uc011ced.1_Splice_Site_p.K301_splice	NM_000670	NP_000661	P08319	ADH4_HUMAN	class II alcohol dehydrogenase, pi subunit						alcohol catabolic process|cellular aldehyde metabolic process|ethanol oxidation|quinone cofactor metabolic process|retinol metabolic process|xenobiotic metabolic process	cytosol|microtubule cytoskeleton	alcohol dehydrogenase activity, zinc-dependent|all-trans retinal binding|benzaldehyde dehydrogenase activity|NAD binding|NADPH:quinone reductase activity|retinol binding|retinol dehydrogenase activity|zinc ion binding			skin(2)	2				OV - Ovarian serous cystadenocarcinoma(123;4.48e-08)	NADH(DB00157)	GGGCTGCTTTCTGTGATGGAG	0.284		NA											10	45					0	0	0	0
KIAA1109	84162	broad.mit.edu	37	4	123160874	123160874	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr4:123160874C>G	uc003ieh.2	+	27	4082	c.4037C>G	c.(4036-4038)TCT>TGT	p.S1346C	KIAA1109_uc003iei.1_Missense_Mutation_p.S1099C|KIAA1109_uc010ins.1_Missense_Mutation_p.S689C|KIAA1109_uc003iek.2_5'UTR	NM_015312	NP_056127	Q2LD37	K1109_HUMAN	fragile site-associated protein	1346					regulation of cell growth|regulation of epithelial cell differentiation	integral to membrane|nucleus				ovary(8)|skin(2)|pancreas(1)|central_nervous_system(1)	12						AGTGATGTCTCTCGAAGTGAT	0.433		NA											6	129					0	0	0	0
KIAA0922	23240	broad.mit.edu	37	4	154502640	154502640	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr4:154502640G>C	uc003inm.3	+	9	872	c.820G>C	c.(820-822)GAA>CAA	p.E274Q	KIAA0922_uc010ipp.2_Missense_Mutation_p.E274Q|KIAA0922_uc010ipq.2_Missense_Mutation_p.E126Q	NM_015196	NP_056011	A2VDJ0	T131L_HUMAN	hypothetical protein LOC23240 isoform 2	274	Extracellular (Potential).					integral to membrane				upper_aerodigestive_tract(1)|ovary(1)	2	all_hematologic(180;0.093)	Renal(120;0.118)				AAAAGAATTTGAAGAAAACAC	0.343		NA											3	33					0	0	0	0
SORBS2	8470	broad.mit.edu	37	4	186567862	186567862	+	Missense_Mutation	SNP	T	T	C			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr4:186567862T>C	uc003iyl.2	-	10	1502	c.644A>G	c.(643-645)TAT>TGT	p.Y215C	SORBS2_uc003iyh.2_Missense_Mutation_p.Y394C|SORBS2_uc011ckw.1_Missense_Mutation_p.Y284C|SORBS2_uc003iyi.2_Missense_Mutation_p.Y301C|SORBS2_uc011ckx.1_Missense_Mutation_p.Y261C|SORBS2_uc003iyk.2_Missense_Mutation_p.Y286C|SORBS2_uc003iym.2_Missense_Mutation_p.Y315C|SORBS2_uc003iyn.1_Missense_Mutation_p.Y261C|SORBS2_uc011cky.1_Missense_Mutation_p.Y278C|SORBS2_uc003iyp.2_Missense_Mutation_p.Y315C|SORBS2_uc011cku.1_Missense_Mutation_p.Y134C|SORBS2_uc011ckv.1_Missense_Mutation_p.Y119C|SORBS2_uc003iyd.2_Missense_Mutation_p.Y394C|SORBS2_uc003iye.2_Missense_Mutation_p.Y215C|SORBS2_uc003iya.2_Missense_Mutation_p.Y215C|SORBS2_uc003iyb.2_Missense_Mutation_p.Y215C|SORBS2_uc003iyc.2_Missense_Mutation_p.Y200C|SORBS2_uc003iyg.2_Missense_Mutation_p.Y301C|SORBS2_uc003iyf.2_Missense_Mutation_p.Y278C|SORBS2_uc003iyo.1_Missense_Mutation_p.Y119C	NM_021069	NP_066547	O94875	SRBS2_HUMAN	sorbin and SH3 domain containing 2 isoform 2	215						actin cytoskeleton|nucleus|perinuclear region of cytoplasm|Z disc	cytoskeletal adaptor activity|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			ovary(1)	1		all_cancers(14;4.27e-52)|all_epithelial(14;6.58e-39)|all_lung(41;1.42e-13)|Lung NSC(41;3.73e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.00692)|Hepatocellular(41;0.00826)|Renal(120;0.00994)|Prostate(90;0.0101)|all_hematologic(60;0.0174)|all_neural(102;0.244)		OV - Ovarian serous cystadenocarcinoma(60;1.54e-09)|BRCA - Breast invasive adenocarcinoma(30;0.000232)|GBM - Glioblastoma multiforme(59;0.000385)|STAD - Stomach adenocarcinoma(60;0.00109)|LUSC - Lung squamous cell carcinoma(40;0.0205)		GCCAGGTTCATATTCAAAAAT	0.428		NA											26	12					0	0	0	0
KLKB1	3818	broad.mit.edu	37	4	187173205	187173205	+	Silent	SNP	A	A	G			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr4:187173205A>G	uc003iyy.2	+	11	1250	c.1179A>G	c.(1177-1179)GGA>GGG	p.G393G	KLKB1_uc011clc.1_Silent_p.G191G|KLKB1_uc011cld.1_Silent_p.G355G	NM_000892	NP_000883	P03952	KLKB1_HUMAN	plasma kallikrein B1 precursor	393	Peptidase S1.				blood coagulation, intrinsic pathway|Factor XII activation|fibrinolysis|plasminogen activation|positive regulation of fibrinolysis	cytoplasm|extracellular space|plasma membrane	serine-type endopeptidase activity			ovary(1)	1		all_cancers(14;1.55e-52)|all_epithelial(14;7.69e-39)|all_lung(41;1.34e-13)|Lung NSC(41;3.58e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.00664)|Hepatocellular(41;0.00886)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|all_neural(102;0.243)		OV - Ovarian serous cystadenocarcinoma(60;1.29e-10)|BRCA - Breast invasive adenocarcinoma(30;3.8e-05)|GBM - Glioblastoma multiforme(59;0.000131)|STAD - Stomach adenocarcinoma(60;0.000292)|LUSC - Lung squamous cell carcinoma(40;0.00241)|READ - Rectum adenocarcinoma(43;0.168)		GCATTGTTGGAGGAACAAACT	0.507		NA											25	15					0	0	0	0
LRRC14B	389257	broad.mit.edu	37	5	192316	192316	+	Silent	SNP	C	C	T			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr5:192316C>T	uc003jal.1	+	1	691	c.663C>T	c.(661-663)AAC>AAT	p.N221N		NM_001080478	NP_001073947	A6NHZ5	LR14B_HUMAN	leucine rich repeat containing 14B	221										skin(1)	1						TGGTGCACAACGTGCGGCTGC	0.716		NA											3	4					0	0	0	0
DNAH5	1767	broad.mit.edu	37	5	13885256	13885256	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr5:13885256G>A	uc003jfd.2	-	19	2867	c.2825C>T	c.(2824-2826)ACG>ATG	p.T942M		NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	942	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					CTTTTTCCTCGTGACTGTCGT	0.423		NA							Kartagener_syndrome				27	42					0	0	0	0
RANBP3L	202151	broad.mit.edu	37	5	36265071	36265071	+	Missense_Mutation	SNP	G	G	T			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr5:36265071G>T	uc003jkh.2	-	6	963	c.470C>A	c.(469-471)ACA>AAA	p.T157K	RANBP3L_uc011cow.1_Missense_Mutation_p.T182K	NM_145000	NP_659437	Q86VV4	RNB3L_HUMAN	RAN binding protein 3-like isoform 2	157					intracellular transport					ovary(1)	1	all_lung(31;4.52e-05)		Epithelial(62;0.0543)|Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|all cancers(62;0.149)|Colorectal(62;0.202)			CTTATTATTTGTTTTTTCTTT	0.418		NA											36	63					1.36e-19	1.45e-19	1	0
RASA1	5921	broad.mit.edu	37	5	86672284	86672284	+	Missense_Mutation	SNP	A	A	G			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr5:86672284A>G	uc003kiw.2	+	16	2204	c.2086A>G	c.(2086-2088)ATA>GTA	p.I696V	RASA1_uc010jav.2_RNA|RASA1_uc003kix.2_Missense_Mutation_p.I519V|RASA1_uc011ctv.1_Missense_Mutation_p.I529V|RASA1_uc011ctw.1_Missense_Mutation_p.I530V|RASA1_uc010jaw.2_Missense_Mutation_p.I518V	NM_002890	NP_002881	P20936	RASA1_HUMAN	RAS p21 protein activator 1 isoform 1	696					cytokinesis|embryo development|intracellular signal transduction|negative regulation of cell-matrix adhesion|negative regulation of neuron apoptosis|negative regulation of Ras protein signal transduction|positive regulation of anti-apoptosis|regulation of actin filament polymerization|regulation of cell shape|regulation of RNA metabolic process|vasculogenesis	cytosol|intrinsic to internal side of plasma membrane	glycoprotein binding|GTPase binding|potassium channel inhibitor activity|Ras GTPase activator activity|receptor binding			upper_aerodigestive_tract(3)|ovary(1)|lung(1)	5		all_cancers(142;8.25e-07)|Lung NSC(167;0.000185)|all_lung(232;0.000222)|Colorectal(57;0.00542)|Ovarian(174;0.0423)		OV - Ovarian serous cystadenocarcinoma(54;4.72e-41)|Epithelial(54;1.51e-36)|all cancers(79;3.76e-31)		CAGCTCCCATATACCATTAAA	0.423		NA											6	24					0	0	0	0
ARSK	153642	broad.mit.edu	37	5	94938983	94938983	+	Missense_Mutation	SNP	A	A	C			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr5:94938983A>C	uc003kld.2	+	8	1522	c.1364A>C	c.(1363-1365)AAA>ACA	p.K455T	ARSK_uc010jbg.2_Missense_Mutation_p.K296T|ARSK_uc011cum.1_RNA	NM_198150	NP_937793	Q6UWY0	ARSK_HUMAN	arylsulfatase K precursor	455						extracellular region	arylsulfatase activity|metal ion binding			pancreas(1)	1		all_cancers(142;3.38e-06)|all_epithelial(76;6.57e-09)|all_lung(232;0.00307)|Lung NSC(167;0.00452)|Ovarian(225;0.00473)		all cancers(79;6.5e-16)		GTTGCTGTAAAATTTCCAGAA	0.308		NA											3	3					0	0	0	0
TRIM36	55521	broad.mit.edu	37	5	114469606	114469606	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr5:114469606G>C	uc003kqs.2	-	8	1994	c.1485C>G	c.(1483-1485)ATC>ATG	p.I495M	TRIM36_uc011cwc.1_Missense_Mutation_p.I483M|TRIM36_uc003kqt.2_Missense_Mutation_p.I340M	NM_018700	NP_061170	Q9NQ86	TRI36_HUMAN	tripartite motif-containing 36 isoform 1	495	Fibronectin type-III.					acrosomal vesicle|cytoskeleton	ligase activity|zinc ion binding			ovary(4)|lung(2)|breast(2)	8		all_cancers(142;0.00133)|all_epithelial(76;2.41e-05)|Prostate(80;0.00955)|Ovarian(225;0.0443)|Breast(839;0.195)		OV - Ovarian serous cystadenocarcinoma(64;3.62e-08)|Epithelial(69;7.69e-08)|all cancers(49;9.33e-06)		AAGGACTACAGATTGAACCCT	0.388		NA											7	38					0	0	0	0
HSPA4	3308	broad.mit.edu	37	5	132427045	132427045	+	Silent	SNP	T	T	C			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr5:132427045T>C	uc003kyj.2	+	12	1820	c.1539T>C	c.(1537-1539)GAT>GAC	p.D513D		NM_002154	NP_002145	P34932	HSP74_HUMAN	heat shock 70kDa protein 4	513					cellular chaperone-mediated protein complex assembly|protein import into mitochondrial outer membrane|response to unfolded protein	cytoplasm|nucleus	ATP binding			lung(1)|breast(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			TGGAAACAGATCAGAATGCAA	0.438		NA											15	28					0	0	0	0
PCDHB6	56130	broad.mit.edu	37	5	140531735	140531735	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr5:140531735G>A	uc003lir.2	+	1	1897	c.1897G>A	c.(1897-1899)GCA>ACA	p.A633T	PCDHB6_uc011dah.1_Missense_Mutation_p.A497T	NM_018939	NP_061762	Q9Y5E3	PCDB6_HUMAN	protocadherin beta 6 precursor	633	Cadherin 6.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			skin(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CGAGCGAGACGCAGCCAAGCA	0.677		NA											9	26					0	0	0	0
ARHGAP26	23092	broad.mit.edu	37	5	142500686	142500686	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr5:142500686G>C	uc011dbj.1	+	18	1707	c.1672G>C	c.(1672-1674)GAG>CAG	p.E558Q	ARHGAP26_uc003lmt.2_Missense_Mutation_p.E558Q|ARHGAP26_uc003lmw.2_Missense_Mutation_p.E558Q	NM_015071	NP_055886	Q9UNA1	RHG26_HUMAN	GTPase regulator associated with the focal	558	Rho-GAP.				actin cytoskeleton organization|filopodium assembly|nervous system development|small GTPase mediated signal transduction	cytoskeleton|cytosol|focal adhesion	cytoskeletal adaptor activity|Rho GTPase activator activity|SH3 domain binding			ovary(1)	1		all_hematologic(541;0.0416)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			CATTGTCATTGAGATCCTAAT	0.443		NA											10	35					0	0	0	0
FBXO38	81545	broad.mit.edu	37	5	147807315	147807315	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr5:147807315C>G	uc003lpf.1	+	15	2578	c.2458C>G	c.(2458-2460)CTG>GTG	p.L820V	FBXO38_uc003lpg.1_Intron|FBXO38_uc003lph.2_Intron	NM_205836	NP_995308	Q6PIJ6	FBX38_HUMAN	F-box protein 38 isoform b	820						cytoplasm|nucleus				ovary(4)|skin(2)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTTTAGGACTCTGCCACAAGG	0.577		NA											13	4					0	0	0	0
FOXI1	2299	broad.mit.edu	37	5	169532981	169532981	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr5:169532981C>T	uc003mai.3	+	1	65	c.20C>T	c.(19-21)CCG>CTG	p.P7L	FOXI1_uc003maj.3_Missense_Mutation_p.P7L	NM_012188	NP_036320	Q12951	FOXI1_HUMAN	forkhead box I1 isoform a	7	Pro-rich.				epidermal cell fate specification|otic placode formation|pattern specification process|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|transcription regulatory region DNA binding			breast(3)|central_nervous_system(1)	4	Renal(175;0.000159)|Lung NSC(126;0.0267)|all_lung(126;0.04)	Medulloblastoma(196;0.0109)|all_neural(177;0.0298)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			TTCGACCTGCCGGCGCCCTCC	0.697		NA							Pendred_syndrome				8	3					0	0	0	0
HUS1B	135458	broad.mit.edu	37	6	656504	656504	+	Silent	SNP	C	C	T			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr6:656504C>T	uc003mtg.2	-	1	461	c.441G>A	c.(439-441)CCG>CCA	p.P147P	EXOC2_uc003mtd.2_Intron|EXOC2_uc003mte.2_Intron|EXOC2_uc011dho.1_Intron	NM_148959	NP_683762	Q8NHY5	HUS1B_HUMAN	HUS1 checkpoint protein B	147											0	Ovarian(93;0.0733)	Breast(5;0.00139)|all_lung(73;0.0691)|all_hematologic(90;0.0895)		OV - Ovarian serous cystadenocarcinoma(45;0.041)|BRCA - Breast invasive adenocarcinoma(62;0.0965)		GCAGGCTGGGCGGCAGGCAGT	0.716		NA											15	24					0	0	0	0
DSP	1832	broad.mit.edu	37	6	7569532	7569532	+	Silent	SNP	C	C	T			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr6:7569532C>T	uc003mxp.1	+	12	1812	c.1533C>T	c.(1531-1533)ATC>ATT	p.I511I	DSP_uc003mxq.1_Silent_p.I511I	NM_004415	NP_004406	P15924	DESP_HUMAN	desmoplakin isoform I	511	Globular 1.|Interacts with plakophilin 1 and junction plakoglobin.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			central_nervous_system(6)|ovary(2)|skin(1)	9	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		TGGGGCTGATCATCCCTCCTC	0.577		NA											21	45					0	0	0	0
MRS2	57380	broad.mit.edu	37	6	24409763	24409763	+	Missense_Mutation	SNP	A	A	G			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr6:24409763A>G	uc003neb.2	+	4	498	c.376A>G	c.(376-378)ATC>GTC	p.I126V	MRS2_uc003nea.2_Missense_Mutation_p.I126V|MRS2_uc011djl.1_Missense_Mutation_p.I126V|MRS2_uc011djm.1_RNA|MRS2_uc011djn.1_Intron|MRS2_uc003nec.2_Missense_Mutation_p.I3V	NM_020662	NP_065713	Q9HD23	MRS2_HUMAN	MRS2-like, magnesium homeostasis factor	126	Mitochondrial matrix (Potential).				ion transport	integral to membrane|mitochondrial inner membrane					0						TGTAATGAGTATCACAGTCAG	0.313		NA											22	39					0	0	0	0
FAM65B	9750	broad.mit.edu	37	6	24843781	24843781	+	Nonsense_Mutation	SNP	G	G	C			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr6:24843781G>C	uc003neo.1	-	14	1405	c.1229C>G	c.(1228-1230)TCA>TGA	p.S410*	FAM65B_uc011djs.1_Nonsense_Mutation_p.S389*|FAM65B_uc011dju.1_Nonsense_Mutation_p.S394*|FAM65B_uc003nep.2_Nonsense_Mutation_p.S360*|FAM65B_uc011djt.1_Nonsense_Mutation_p.S360*	NM_014722	NP_055537	Q9Y4F9	FA65B_HUMAN	hypothetical protein LOC9750 isoform 1	410					cell differentiation|muscle organ development	cytoskeleton|filopodium|mitochondrion	binding			ovary(1)	1						AGGTAGATTTGACTATAGATA	0.413		NA											3	17					0	0	0	0
HIST1H4C	8364	broad.mit.edu	37	6	26104378	26104378	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr6:26104378G>C	uc003ngi.2	+	1	203	c.203G>C	c.(202-204)CGA>CCA	p.R68P		NM_003542	NP_003533	P62805	H4_HUMAN	histone cluster 1, H4c	68					CenH3-containing nucleosome assembly at centromere|negative regulation of megakaryocyte differentiation|phosphatidylinositol-mediated signaling|telomere maintenance	nucleoplasm|nucleosome	DNA binding|protein binding				0						AACGTTATTCGAGACGCCGTC	0.527		NA											9	29					0	0	0	0
BRPF3	27154	broad.mit.edu	37	6	36193116	36193116	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr6:36193116G>C	uc003olv.3	+	11	3478	c.3254G>C	c.(3253-3255)CGA>CCA	p.R1085P	BRPF3_uc010jwb.2_Missense_Mutation_p.R815P|BRPF3_uc011dtj.1_RNA|BRPF3_uc010jwc.2_Intron|BRPF3_uc011dtk.1_Missense_Mutation_p.R751P|BRPF3_uc010jwd.2_5'UTR	NM_015695	NP_056510	Q9ULD4	BRPF3_HUMAN	bromodomain and PHD finger containing, 3	1085	PWWP.				histone H3 acetylation|platelet activation|platelet degranulation	cytosol|extracellular region|MOZ/MORF histone acetyltransferase complex	protein binding|zinc ion binding			ovary(1)|skin(1)	2						GCCAAGTGCCGAGGCTACCCC	0.642		NA											4	26					0	0	0	0
KIF6	221458	broad.mit.edu	37	6	39311516	39311516	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr6:39311516G>C	uc003oot.2	-	22	2492	c.2397C>G	c.(2395-2397)ATC>ATG	p.I799M	KIF6_uc003oos.2_Missense_Mutation_p.I250M|KIF6_uc010jwz.1_Missense_Mutation_p.I174M|KIF6_uc010jxa.1_Missense_Mutation_p.I573M|KIF6_uc011dua.1_Missense_Mutation_p.I782M|KIF6_uc010jxb.1_Missense_Mutation_p.I743M	NM_145027	NP_659464	Q6ZMV9	KIF6_HUMAN	kinesin family member 6	799					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity|protein binding			breast(2)|central_nervous_system(1)	3						GTCTGGCCTTGATGAAGGCGA	0.582		NA											15	35					0	0	0	0
HSP90AB1	3326	broad.mit.edu	37	6	44216418	44216418	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr6:44216418C>G	uc003oxa.1	+	2	136	c.52C>G	c.(52-54)CAG>GAG	p.Q18E	HSP90AB1_uc011dvr.1_Missense_Mutation_p.Q18E|HSP90AB1_uc003oxb.1_Missense_Mutation_p.Q18E|HSP90AB1_uc011dvs.1_5'UTR|HSP90AB1_uc003oxc.1_5'Flank	NM_007355	NP_031381	P08238	HS90B_HUMAN	heat shock 90kDa protein 1, beta	18					axon guidance|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of nitric oxide biosynthetic process|protein folding|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|response to unfolded protein	cytosol|melanosome	ATP binding|nitric-oxide synthase regulator activity|TPR domain binding|unfolded protein binding	p.Q18*(1)		lung(3)|breast(1)	4	all_cancers(18;1.7e-05)|all_lung(25;0.00747)|Hepatocellular(11;0.00908)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)			TTTTGCCTTTCAGGCAGAAAT	0.423		NA											15	115					0	0	0	0
ELOVL5	60481	broad.mit.edu	37	6	53156755	53156755	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr6:53156755C>G	uc003pbq.1	-	3	513	c.65G>C	c.(64-66)AGA>ACA	p.R22T	ELOVL5_uc003pbr.1_Missense_Mutation_p.R22T|ELOVL5_uc011dwx.1_Missense_Mutation_p.R22T|ELOVL5_uc003pbs.1_Missense_Mutation_p.R22T	NM_021814	NP_068586	Q9NYP7	ELOV5_HUMAN	elongation of very long chain fatty acids-like	22					fatty acid elongation, monounsaturated fatty acid|fatty acid elongation, polyunsaturated fatty acid|long-chain fatty-acyl-CoA biosynthetic process|triglyceride biosynthetic process|very long-chain fatty acid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	fatty acid elongase activity|protein binding				0	Lung NSC(77;0.116)					TCCTTTTACTCTAGTATCTGa	0.274		NA											30	26					0	0	0	0
DOPEY1	23033	broad.mit.edu	37	6	83863897	83863897	+	Splice_Site	SNP	A	A	T			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr6:83863897A>T	uc003pjs.1	+	33	6650	c.6390_splice	c.e33-2	p.H2130_splice	DOPEY1_uc011dyy.1_Splice_Site_p.H2121_splice|DOPEY1_uc010kbl.1_Splice_Site_p.H2121_splice|DOPEY1_uc003pjt.2_Splice_Site	NM_015018	NP_055833	Q5JWR5	DOP1_HUMAN	dopey family member 1						protein transport					ovary(2)|breast(1)|central_nervous_system(1)	4		all_cancers(76;2.29e-06)|Acute lymphoblastic leukemia(125;3.41e-06)|all_hematologic(105;0.000865)|all_epithelial(107;0.00203)		BRCA - Breast invasive adenocarcinoma(397;0.053)		TATCTCTTTCAGTTGGAGAGC	0.363		NA											23	39					0	0	0	0
TSPYL4	23270	broad.mit.edu	37	6	116574228	116574228	+	Missense_Mutation	SNP	T	T	C			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr6:116574228T>C	uc003pwn.2	-	1	1034	c.944A>G	c.(943-945)TAT>TGT	p.Y315C	DSE_uc011ebf.1_5'Flank|TSPYL4_uc011ebe.1_Missense_Mutation_p.Y143C|uc003pwo.1_5'Flank	NM_021648	NP_067680	Q9UJ04	TSYL4_HUMAN	TSPY-like 4	315					nucleosome assembly	nucleus					0		all_cancers(87;0.0144)|all_epithelial(87;0.021)|Colorectal(196;0.234)		all cancers(137;0.045)|OV - Ovarian serous cystadenocarcinoma(136;0.0666)|GBM - Glioblastoma multiforme(226;0.095)|Epithelial(106;0.125)		TCTGCGTTCATATTCCTTGAC	0.552		NA											17	29					0	0	0	0
GRM1	2911	broad.mit.edu	37	6	146673517	146673517	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr6:146673517G>C	uc010khw.1	+	5	1788	c.1318G>C	c.(1318-1320)GAT>CAT	p.D440H	GRM1_uc010khv.1_Missense_Mutation_p.D440H|GRM1_uc003qll.2_Missense_Mutation_p.D440H|GRM1_uc011edz.1_Missense_Mutation_p.D440H|GRM1_uc011eea.1_Missense_Mutation_p.D440H	NM_000838	NP_000829	Q13255	GRM1_HUMAN	glutamate receptor, metabotropic 1 isoform alpha	440	Extracellular (Potential).				synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			lung(8)|ovary(4)|central_nervous_system(3)|large_intestine(2)|breast(2)	19		Ovarian(120;0.0387)		OV - Ovarian serous cystadenocarcinoma(155;5.35e-08)|GBM - Glioblastoma multiforme(68;0.00762)	Acamprosate(DB00659)|L-Glutamic Acid(DB00142)	GGGCCTCTGCGATGCCATGAA	0.547		NA											10	89					0	0	0	0
PNLDC1	154197	broad.mit.edu	37	6	160222146	160222146	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr6:160222146C>G	uc003qsx.1	+	3	274	c.103C>G	c.(103-105)CTT>GTT	p.L35V	PNLDC1_uc003qsy.1_Missense_Mutation_p.L46V	NM_173516	NP_775787	Q8NA58	PNDC1_HUMAN	poly(A)-specific ribonuclease (PARN)-like domain	35	Cytoplasmic (Potential).					integral to membrane|nucleus	nucleic acid binding				0		Breast(66;0.00519)|Ovarian(120;0.123)		OV - Ovarian serous cystadenocarcinoma(65;1.55e-18)|BRCA - Breast invasive adenocarcinoma(81;5.87e-06)		TGTTCACAGTCTTTTTGATTT	0.483		NA											5	117					0	0	0	0
MAP3K4	4216	broad.mit.edu	37	6	161469773	161469773	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr6:161469773C>G	uc003qtn.2	+	3	611	c.469C>G	c.(469-471)CAT>GAT	p.H157D	MAP3K4_uc010kkc.1_Missense_Mutation_p.R157G|MAP3K4_uc003qto.2_Missense_Mutation_p.H157D|MAP3K4_uc011efz.1_RNA|MAP3K4_uc011ega.1_Translation_Start_Site	NM_005922	NP_005913	Q9Y6R4	M3K4_HUMAN	mitogen-activated protein kinase kinase kinase 4	157					activation of MAPKK activity|JNK cascade|positive regulation of JUN kinase activity	perinuclear region of cytoplasm	ATP binding|MAP kinase kinase kinase activity|metal ion binding|protein binding			ovary(3)|lung(3)|skin(2)|stomach(1)	9		Breast(66;0.000776)|Ovarian(120;0.0367)|Prostate(117;0.0771)		OV - Ovarian serous cystadenocarcinoma(65;1.85e-18)|BRCA - Breast invasive adenocarcinoma(81;3.04e-05)		AGAGCGTGATCGTAAAAAAAA	0.403		NA											7	75					0	0	0	0
DLL1	28514	broad.mit.edu	37	6	170592437	170592437	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr6:170592437C>T	uc003qxm.2	-	9	2400	c.1930G>A	c.(1930-1932)GTG>ATG	p.V644M		NM_005618	NP_005609	O00548	DLL1_HUMAN	delta-like 1 precursor	644	Cytoplasmic (Potential).				cell communication|cell fate determination|hemopoiesis|Notch receptor processing|Notch signaling pathway|regulation of cell adhesion	extracellular region|integral to plasma membrane	calcium ion binding|Notch binding			lung(4)|ovary(1)	5		Breast(66;5.08e-05)|Ovarian(120;0.125)|Esophageal squamous(34;0.246)		OV - Ovarian serous cystadenocarcinoma(33;6.71e-23)|BRCA - Breast invasive adenocarcinoma(81;4.81e-06)|GBM - Glioblastoma multiforme(31;0.0584)		AGGTCCTGCACGAGGTTATAG	0.627		NA											28	57					0	0	0	0
ETV1	2115	broad.mit.edu	37	7	14027742	14027742	+	Silent	SNP	G	G	A			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr7:14027742G>A	uc011jxq.1	-	4	841	c.102C>T	c.(100-102)TTC>TTT	p.F34F	ETV1_uc011jxn.1_5'Flank|ETV1_uc011jxo.1_5'Flank|ETV1_uc011jxp.1_5'Flank|ETV1_uc003ssw.3_Silent_p.F34F|ETV1_uc003ssx.2_RNA|ETV1_uc011jxr.1_Silent_p.F34F|ETV1_uc011jxs.1_Silent_p.F34F|ETV1_uc010ktv.2_5'Flank	NM_004956	NP_004947	P50549	ETV1_HUMAN	ets variant gene 1 isoform a	34					transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		TMPRSS2/ETV1(24)|EWSR1/ETV1(7)	prostate(24)|soft_tissue(4)|bone(3)|lung(2)|central_nervous_system(1)|ovary(1)	35						CTCTGTTAATGAATTTTCTTT	0.378		NA	T	EWSR1|TMPRSS2|SLC45A3|C15orf21|HNRNPA2B1. ACSL3	Ewing sarcoma|prostate								4	36					0	0	0	0
DNAH11	8701	broad.mit.edu	37	7	21745088	21745088	+	Missense_Mutation	SNP	T	T	G			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr7:21745088T>G	uc003svc.2	+	40	6531	c.6500T>G	c.(6499-6501)CTT>CGT	p.L2167R		NM_003777	NP_003768	Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	2167	AAA 2 (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(8)|large_intestine(3)|pancreas(3)|central_nervous_system(1)	15						GTTGTCCAGCTTGAGGAACTG	0.433		NA							Kartagener_syndrome				7	12					0	0	0	0
FZD9	8326	broad.mit.edu	37	7	72849813	72849813	+	Silent	SNP	A	A	G			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr7:72849813A>G	uc003tyb.2	+	1	1705	c.1476A>G	c.(1474-1476)GGA>GGG	p.G492G		NM_003508	NP_003499	O00144	FZD9_HUMAN	frizzled 9 precursor	492	Extracellular (Potential).				B cell differentiation|brain development|canonical Wnt receptor signaling pathway|embryo development|gonad development|neuroblast proliferation|vasculature development	cell surface|filopodium membrane|integral to membrane|perinuclear region of cytoplasm	G-protein coupled receptor activity|PDZ domain binding|protein heterodimerization activity|protein homodimerization activity|Wnt receptor activity|Wnt-protein binding			central_nervous_system(1)	1		Lung NSC(55;0.0659)|all_lung(88;0.152)				CGGGGCCCGGAGGCCGGAGGG	0.652		NA											4	40					0	0	0	0
GTF2IRD1	9569	broad.mit.edu	37	7	73952488	73952488	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr7:73952488G>A	uc003uaq.2	+	12	1825	c.1432G>A	c.(1432-1434)GAA>AAA	p.E478K	GTF2IRD1_uc010lbq.2_Missense_Mutation_p.E510K|GTF2IRD1_uc003uap.2_Missense_Mutation_p.E478K|GTF2IRD1_uc003uar.1_Missense_Mutation_p.E478K	NM_016328	NP_057412	Q9UHL9	GT2D1_HUMAN	GTF2I repeat domain containing 1 isoform 1	478						nucleus	DNA binding|protein binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity			ovary(4)	4						CAGCATGTCTGAAGACTGTGG	0.642		NA											5	65					0	0	0	0
CACNA2D1	781	broad.mit.edu	37	7	81964507	81964507	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr7:81964507C>G	uc003uhr.1	-	3	494	c.238G>C	c.(238-240)GAA>CAA	p.E80Q		NM_000722	NP_000713	P54289	CA2D1_HUMAN	calcium channel, voltage-dependent, alpha	80	Extracellular (Potential).					voltage-gated calcium channel complex	metal ion binding			ovary(5)|pancreas(1)	6					Felodipine(DB01023)|Gabapentin(DB00996)|Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Nifedipine(DB01115)	GCTGCAATTTCTACCAGCTGG	0.343		NA											57	106					0	0	0	0
PCLO	27445	broad.mit.edu	37	7	82595320	82595320	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr7:82595320G>A	uc003uhx.2	-	4	4073	c.3784C>T	c.(3784-3786)CAT>TAT	p.H1262Y	PCLO_uc003uhv.2_Missense_Mutation_p.H1262Y	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	1201					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						AGTAAGTCATGTTTCTGTTCT	0.418		NA											74	96					0	0	0	0
C7orf63	79846	broad.mit.edu	37	7	89929196	89929196	+	Missense_Mutation	SNP	T	T	A			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr7:89929196T>A	uc010lep.2	+	17	2124	c.1873T>A	c.(1873-1875)TTC>ATC	p.F625I	C7orf63_uc003ukf.2_RNA|C7orf63_uc003ukg.2_Missense_Mutation_p.F300I|C7orf63_uc011khj.1_Missense_Mutation_p.F607I|C7orf63_uc011khk.1_Missense_Mutation_p.F187I	NM_001039706	NP_001034795	A5D8W1	CG063_HUMAN	hypothetical protein LOC79846 isoform 1	625							binding			ovary(1)	1						CCAAAAAAAATTCTGTAATCT	0.323		NA											8	10					0	0	0	0
FAM133B	257415	broad.mit.edu	37	7	92195342	92195342	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr7:92195342G>A	uc003umc.2	-	10	744	c.643C>T	c.(643-645)CGA>TGA	p.R215*	FAM133B_uc003umb.2_Nonsense_Mutation_p.R205*|FAM133B_uc003umd.2_RNA	NM_152789	NP_690002	Q5BKY9	F133B_HUMAN	hypothetical protein LOC257415 isoform 1	215	Lys-rich.							p.R215Q(1)		ovary(1)	1	all_cancers(62;7.39e-11)|all_epithelial(64;7.03e-10)|Breast(17;0.00201)|all_lung(186;0.0384)|Lung NSC(181;0.053)|all_hematologic(106;0.237)		STAD - Stomach adenocarcinoma(4;6.16e-07)|GBM - Glioblastoma multiforme(5;9.78e-06)|all cancers(6;1.67e-05)|Epithelial(20;0.113)|LUSC - Lung squamous cell carcinoma(200;0.225)|Lung(22;0.23)			GCTTTTTCTCGTTCTTCACTG	0.323		NA											11	16					0	0	0	0
SPDYE3	441272	broad.mit.edu	37	7	99917593	99917593	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr7:99917593G>C	uc003uug.1	+	5	739	c.499G>C	c.(499-501)GAT>CAT	p.D167H	uc011kjm.1_5'Flank	NM_001004351	NP_001004351	A6NKU9	SPDE3_HUMAN	speedy homolog E3	544											0						GTGGGCGCGAGATCGCGCCCA	0.582		NA											9	59					0	0	0	0
MUC17	140453	broad.mit.edu	37	7	100686712	100686712	+	Silent	SNP	G	G	A			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr7:100686712G>A	uc003uxp.1	+	3	12068	c.12015G>A	c.(12013-12015)GTG>GTA	p.V4005V	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	4005	Extracellular (Potential).					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					TCACATATGTGACCATGTCTA	0.488		NA											11	318					0	0	0	0
MUC17	140453	broad.mit.edu	37	7	100686943	100686943	+	Silent	SNP	G	G	A			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr7:100686943G>A	uc003uxp.1	+	3	12299	c.12246G>A	c.(12244-12246)ACG>ACA	p.T4082T	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	4082	Extracellular (Potential).					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					CCTCCTCCACGACTGTGAACC	0.572		NA											40	280					0	0	0	0
PLOD3	8985	broad.mit.edu	37	7	100855553	100855553	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr7:100855553C>T	uc003uyd.2	-	10	1564	c.1108G>A	c.(1108-1110)GAG>AAG	p.E370K	PLOD3_uc010lhs.2_5'UTR	NM_001084	NP_001075	O60568	PLOD3_HUMAN	procollagen-lysine, 2-oxoglutarate 5-dioxygenase	370					protein modification process	rough endoplasmic reticulum membrane	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-lysine 5-dioxygenase activity|protein binding			ovary(1)|skin(1)	2	Lung NSC(181;0.168)|all_lung(186;0.215)				Succinic acid(DB00139)|Vitamin C(DB00126)	TCCCTGGCCTCGCCTGGGCTC	0.667		NA											23	165					0	0	0	0
PLOD3	8985	broad.mit.edu	37	7	100859523	100859523	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr7:100859523C>G	uc003uyd.2	-	4	879	c.423G>C	c.(421-423)GAG>GAC	p.E141D	ZNHIT1_uc003uye.2_5'Flank|ZNHIT1_uc003uyf.2_5'Flank	NM_001084	NP_001075	O60568	PLOD3_HUMAN	procollagen-lysine, 2-oxoglutarate 5-dioxygenase	141					protein modification process	rough endoplasmic reticulum membrane	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-lysine 5-dioxygenase activity|protein binding			ovary(1)|skin(1)	2	Lung NSC(181;0.168)|all_lung(186;0.215)				Succinic acid(DB00139)|Vitamin C(DB00126)	AGCAGAAGCTCTCTGCAGAGA	0.637		NA											17	97					0	0	0	0
KIAA1549	57670	broad.mit.edu	37	7	138602191	138602191	+	Silent	SNP	G	G	A			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr7:138602191G>A	uc011kql.1	-	2	2230	c.2181C>T	c.(2179-2181)CTC>CTT	p.L727L	KIAA1549_uc003vuk.3_Silent_p.L677L|KIAA1549_uc011kqj.1_Silent_p.L727L	NM_020910	NP_065961	Q9HCM3	K1549_HUMAN	hypothetical protein LOC57670 isoform 1	727	Ser-rich.					integral to membrane			KIAA1549/BRAF(229)	central_nervous_system(229)|pancreas(1)	230						CAACAAACTCGAGAGAATCAG	0.468		NA	O	BRAF	pilocytic astrocytoma								4	26					0	0	0	0
ASH2L	9070	broad.mit.edu	37	8	37964677	37964677	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr8:37964677G>C	uc003xkt.3	+	3	452	c.394G>C	c.(394-396)GAT>CAT	p.D132H	ASH2L_uc011lbk.1_Intron|ASH2L_uc003xku.3_Missense_Mutation_p.D38H|ASH2L_uc010lwa.2_Missense_Mutation_p.D38H	NM_004674	NP_004665	Q9UBL3	ASH2L_HUMAN	ash2-like isoform a	132	C4-type.				hemopoiesis|histone H3-K4 methylation|positive regulation of cell proliferation|regulation of transcription, DNA-dependent|response to estrogen stimulus|transcription from RNA polymerase II promoter	Set1C/COMPASS complex	metal ion binding|protein binding|transcription regulatory region DNA binding			ovary(1)|lung(1)	2	Colorectal(12;0.000501)	Lung NSC(58;0.0295)|all_lung(54;0.0413)				ATTTGGCATAGATACCTCGTG	0.433		NA											12	228					0	0	0	0
WHSC1L1	54904	broad.mit.edu	37	8	38172976	38172976	+	Silent	SNP	C	C	T			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr8:38172976C>T	uc003xli.2	-	11	2591	c.2073G>A	c.(2071-2073)TCG>TCA	p.S691S	WHSC1L1_uc011lbm.1_Silent_p.S691S|WHSC1L1_uc010lwe.2_Silent_p.S691S	NM_023034	NP_075447	Q9BZ95	NSD3_HUMAN	WHSC1L1 protein isoform long	691					cell differentiation|cell growth|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome	histone-lysine N-methyltransferase activity|zinc ion binding			breast(1)	1	Colorectal(12;0.000442)|Esophageal squamous(3;0.0725)	all_lung(54;0.00787)|Lung NSC(58;0.0295)|Hepatocellular(245;0.065)	Epithelial(3;3.12e-43)|all cancers(3;1.72e-38)|BRCA - Breast invasive adenocarcinoma(5;2.84e-27)|LUSC - Lung squamous cell carcinoma(2;2.79e-25)|Lung(2;5.03e-23)|COAD - Colon adenocarcinoma(9;0.0511)			TGCCTCTTCTCGACAAACTTG	0.428		NA	T	NUP98	AML								29	271					0	0	0	0
CEBPD	1052	broad.mit.edu	37	8	48650425	48650425	+	Silent	SNP	G	G	A			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr8:48650425G>A	uc003xqh.1	-	1	302	c.258C>T	c.(256-258)TTC>TTT	p.F86F	KIAA0146_uc003xqg.1_Intron	NM_005195	NP_005186	P49716	CEBPD_HUMAN	CCAAT/enhancer binding protein delta	86					transcription from RNA polymerase II promoter	nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0		all_cancers(86;0.0782)|Lung NSC(58;0.00363)|all_epithelial(80;0.0042)|all_lung(54;0.00914)				GATTGCTGTTGAAGAGGTCGG	0.612		NA											5	5					0	0	0	0
PXDNL	137902	broad.mit.edu	37	8	52320812	52320812	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr8:52320812C>G	uc003xqu.3	-	17	3473	c.3372G>C	c.(3370-3372)CAG>CAC	p.Q1124H	PXDNL_uc003xqt.3_RNA	NM_144651	NP_653252	A1KZ92	PXDNL_HUMAN	peroxidasin homolog-like precursor	1124					hydrogen peroxide catabolic process	extracellular space	heme binding|peroxidase activity			ovary(1)|pancreas(1)	2		all_cancers(86;0.107)|Lung NSC(129;0.00641)|all_epithelial(80;0.00716)|all_lung(136;0.015)				AGAAGAGCCTCTGGGTCAGCT	0.577		NA											11	64					0	0	0	0
NSMAF	8439	broad.mit.edu	37	8	59511881	59511881	+	Missense_Mutation	SNP	T	T	C			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr8:59511881T>C	uc003xtt.2	-	19	1709	c.1495A>G	c.(1495-1497)AGC>GGC	p.S499G	NSMAF_uc011lee.1_Missense_Mutation_p.S530G	NM_003580	NP_003571	Q92636	FAN_HUMAN	neutral sphingomyelinase (N-SMase) activation	499	BEACH.				ceramide metabolic process	cytoplasm|soluble fraction	protein binding|receptor signaling protein activity			ovary(1)	1		all_lung(136;0.174)|Lung NSC(129;0.2)				ACATAATTGCTTTCCAATGCA	0.393		NA											49	73					0	0	0	0
CSPP1	79848	broad.mit.edu	37	8	68071344	68071344	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr8:68071344G>C	uc003xxi.2	+	21	2631	c.2600G>C	c.(2599-2601)AGA>ACA	p.R867T	CSPP1_uc003xxh.1_RNA|CSPP1_uc003xxj.2_Missense_Mutation_p.R832T|CSPP1_uc003xxk.2_Missense_Mutation_p.R487T	NM_001077204	NP_001070672	Q1MSJ5	CSPP1_HUMAN	centrosome spindle pole associated protein 1	867						centrosome|microtubule|spindle				ovary(3)|breast(2)	5	Breast(64;0.214)	Lung NSC(129;0.0908)|all_lung(136;0.152)	Epithelial(68;0.00145)|OV - Ovarian serous cystadenocarcinoma(28;0.00589)|all cancers(69;0.0069)|BRCA - Breast invasive adenocarcinoma(89;0.153)			TACTGTGAAAGAGACAATTTG	0.279		NA											8	107					0	0	0	0
FAM92A1	137392	broad.mit.edu	37	8	94740469	94740469	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr8:94740469G>A	uc010maq.2	+	8	917	c.814G>A	c.(814-816)GAA>AAA	p.E272K	FAM92A1_uc003yfv.3_RNA|FAM92A1_uc003yfx.3_RNA|FAM92A1_uc003yfw.3_RNA|FAM92A1_uc010mar.2_Missense_Mutation_p.E79K	NM_145269	NP_660312	A1XBS5	F92A1_HUMAN	hypothetical protein LOC137392	272											0	Breast(36;2.4e-06)		BRCA - Breast invasive adenocarcinoma(8;0.0168)			TCAACAAGCAGAAGATGATGA	0.279		NA											5	46					0	0	0	0
KIAA1429	25962	broad.mit.edu	37	8	95550492	95550492	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr8:95550492C>G	uc003ygo.1	-	3	275	c.262G>C	c.(262-264)GGA>CGA	p.G88R	KIAA1429_uc003ygp.2_Missense_Mutation_p.G88R	NM_015496	NP_056311	Q69YN4	VIR_HUMAN	hypothetical protein LOC25962 isoform 1	88					mRNA processing|RNA splicing	nucleus				ovary(1)|skin(1)	2	Breast(36;3.29e-05)		BRCA - Breast invasive adenocarcinoma(8;0.00185)			ACATACCTTCCCAACCTATCG	0.368		NA											21	38					0	0	0	0
MTDH	92140	broad.mit.edu	37	8	98735238	98735238	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr8:98735238G>C	uc003yhz.2	+	11	1981	c.1653G>C	c.(1651-1653)AAG>AAC	p.K551N	MTDH_uc010mbf.2_RNA	NM_178812	NP_848927	Q86UE4	LYRIC_HUMAN	metadherin	551	Cytoplasmic (Potential).				lipopolysaccharide-mediated signaling pathway|negative regulation of apoptosis|negative regulation of transcription from RNA polymerase II promoter|positive regulation of angiogenesis|positive regulation of autophagy|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of protein kinase B signaling cascade	apical plasma membrane|endoplasmic reticulum membrane|integral to membrane|intercellular canaliculus|nuclear body|nuclear membrane|nucleolus|perinuclear region of cytoplasm|tight junction	NF-kappaB binding|RNA polymerase II transcription factor binding|transcription coactivator activity			liver(1)|central_nervous_system(1)	2	Breast(36;2.56e-06)		OV - Ovarian serous cystadenocarcinoma(57;0.178)			CAAATACCAAGCAAAATAGTG	0.373		NA											32	95					0	0	0	0
VPS13B	157680	broad.mit.edu	37	8	100847876	100847876	+	Silent	SNP	A	A	G			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr8:100847876A>G	uc003yiv.2	+	54	10038	c.9927A>G	c.(9925-9927)TTA>TTG	p.L3309L	VPS13B_uc003yiw.2_Silent_p.L3284L	NM_017890	NP_060360	Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13B isoform 5	3309					protein transport					ovary(7)|skin(4)|lung(3)|central_nervous_system(2)|pancreas(2)|breast(1)|kidney(1)	20	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			CCAAAGACTTACTTCCAAGCC	0.428		NA											21	48					0	0	0	0
PABPC1	26986	broad.mit.edu	37	8	101733737	101733737	+	Silent	SNP	C	C	G			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr8:101733737C>G	uc003yjs.1	-	1	579	c.75G>C	c.(73-75)GCG>GCC	p.A25A	PABPC1_uc011lhc.1_Silent_p.A25A|PABPC1_uc011lhd.1_Intron|PABPC1_uc003yjt.1_Silent_p.A25A|PABPC1_uc003yju.2_RNA	NM_002568	NP_002559	P11940	PABP1_HUMAN	poly(A) binding protein, cytoplasmic 1	25	RRM 1.				mRNA polyadenylation|mRNA stabilization|negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA poly(A) tail shortening|translation	catalytic step 2 spliceosome|cytosol	nucleotide binding|poly(A) RNA binding|protein C-terminus binding|translation activator activity				0	all_cancers(14;6.8e-05)|all_epithelial(15;3.16e-07)|Lung NSC(17;0.000453)|all_lung(17;0.00125)		Epithelial(11;6.37e-11)|all cancers(13;1.11e-08)|OV - Ovarian serous cystadenocarcinoma(57;3.91e-05)|STAD - Stomach adenocarcinoma(118;0.206)			CGTAGAGCATCGCCTCGGTCA	0.672		NA											7	43					0	0	0	0
KLF10	7071	broad.mit.edu	37	8	103664280	103664280	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr8:103664280G>C	uc011lhk.1	-	3	434	c.280C>G	c.(280-282)CCA>GCA	p.P94A	KLF10_uc011lhj.1_Missense_Mutation_p.P83A	NM_005655	NP_005646	Q13118	KLF10_HUMAN	Kruppel-like factor 10 isoform a	94					cell proliferation|cell-cell signaling|negative regulation of cell proliferation|negative regulation of transcription from RNA polymerase II promoter|skeletal system development|transforming growth factor beta receptor signaling pathway	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0	all_epithelial(15;5.63e-07)|Lung NSC(17;8.18e-05)|all_lung(17;0.000169)		OV - Ovarian serous cystadenocarcinoma(57;0.000112)|STAD - Stomach adenocarcinoma(118;0.0826)			CTGTAAGGTGGAGTCAAACAC	0.343		NA									OREG0018913	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	42	32					0	0	0	0
CSMD3	114788	broad.mit.edu	37	8	114031357	114031357	+	Silent	SNP	G	G	A			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr8:114031357G>A	uc003ynu.2	-	6	1128	c.969C>T	c.(967-969)CTC>CTT	p.L323L	CSMD3_uc003ynt.2_Silent_p.L283L|CSMD3_uc011lhx.1_Silent_p.L323L|CSMD3_uc010mcx.1_Silent_p.L323L	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	323	Extracellular (Potential).|CUB 2.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						AATGCAGTCTGAGCCAGTTTT	0.353		NA								HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			6	115					0	0	0	0
ZC3H3	23144	broad.mit.edu	37	8	144621302	144621302	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr8:144621302G>A	uc003yyd.2	-	2	264	c.235C>T	c.(235-237)CGG>TGG	p.R79W		NM_015117	NP_055932	Q8IXZ2	ZC3H3_HUMAN	zinc finger CCCH-type containing 3	79					mRNA polyadenylation|poly(A)+ mRNA export from nucleus|regulation of mRNA export from nucleus	nucleus	nucleic acid binding|zinc ion binding			skin(1)	1	all_cancers(97;8.64e-11)|all_epithelial(106;6.43e-09)|Lung NSC(106;0.000202)|all_lung(105;0.000548)|Ovarian(258;0.0212)|Acute lymphoblastic leukemia(118;0.155)		Colorectal(110;0.107)|BRCA - Breast invasive adenocarcinoma(115;0.107)			CCCGGGGGCCGATTCACGAGG	0.672		NA											62	46					0	0	0	0
ZNF251	90987	broad.mit.edu	37	8	145947498	145947498	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr8:145947498C>T	uc003zdv.3	-	5	1803	c.1547G>A	c.(1546-1548)CGT>CAT	p.R516H		NM_138367	NP_612376	Q9BRH9	ZN251_HUMAN	zinc finger protein 251	516					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_cancers(97;3.54e-11)|all_epithelial(106;2.65e-10)|Lung NSC(106;4.08e-05)|all_lung(105;0.000125)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.75e-39)|Epithelial(56;7.54e-38)|all cancers(56;6.19e-33)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.11)	GBM - Glioblastoma multiforme(99;0.198)		TCTGCACTTACGAGTCTCTCC	0.532		NA											28	62					0	0	0	0
CDKN2A	1029	broad.mit.edu	37	9	21971029	21971029	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr9:21971029C>T	uc003zpk.2	-	2	541	c.329G>A	c.(328-330)TGG>TAG	p.W110*	MTAP_uc003zpi.1_Intron|CDKN2A_uc003zpj.2_3'UTR|CDKN2A_uc010miu.2_RNA|CDKN2A_uc003zpl.2_Silent_p.L165L	NM_000077	NP_000068	P42771	CD2A1_HUMAN	cyclin-dependent kinase inhibitor 2A isoform 1	110	ANK 4.				cell cycle arrest|cell cycle checkpoint|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of cell-matrix adhesion|negative regulation of cyclin-dependent protein kinase activity|negative regulation of NF-kappaB transcription factor activity|positive regulation of macrophage apoptosis|positive regulation of smooth muscle cell apoptosis|Ras protein signal transduction|replicative senescence	cytosol|nucleus	cyclin-dependent protein kinase inhibitor activity|NF-kappaB binding|protein binding|protein binding|protein kinase binding	p.0?(1112)|p.W110*(38)|p.?(13)|p.H83fs*2(2)|p.W110fs*9(1)|p.D105fs*8(1)|p.A68fs*3(1)|p.R107fs*33(1)|p.W110fs*36(1)|p.W110C(1)		haematopoietic_and_lymphoid_tissue(647)|skin(419)|upper_aerodigestive_tract(414)|central_nervous_system(381)|lung(325)|pancreas(244)|oesophagus(230)|urinary_tract(225)|pleura(94)|liver(91)|soft_tissue(79)|bone(77)|ovary(76)|biliary_tract(71)|stomach(46)|breast(46)|kidney(39)|NS(28)|thyroid(24)|cervix(23)|meninges(18)|genital_tract(15)|endometrium(13)|prostate(11)|autonomic_ganglia(10)|salivary_gland(10)|large_intestine(9)|adrenal_gland(6)|eye(4)|vulva(2)|small_intestine(1)	3678		all_cancers(5;0)|Acute lymphoblastic leukemia(3;0)|all_hematologic(3;0)|all_epithelial(2;2.37e-290)|Lung NSC(2;1.26e-139)|all_lung(2;4.48e-131)|Glioma(2;3.26e-60)|all_neural(2;2.1e-52)|Renal(3;1.07e-46)|Esophageal squamous(3;3.83e-46)|Melanoma(2;2.74e-34)|Breast(3;1.14e-11)|Ovarian(3;0.000128)|Hepatocellular(5;0.00162)|Colorectal(97;0.172)		all cancers(2;0)|GBM - Glioblastoma multiforme(3;0)|Lung(2;4.07e-74)|Epithelial(2;1.08e-61)|LUSC - Lung squamous cell carcinoma(2;3.82e-48)|LUAD - Lung adenocarcinoma(2;4.56e-26)|OV - Ovarian serous cystadenocarcinoma(39;7.64e-10)|BRCA - Breast invasive adenocarcinoma(2;5.01e-09)|STAD - Stomach adenocarcinoma(4;4.63e-07)|Kidney(2;5.79e-07)|KIRC - Kidney renal clear cell carcinoma(2;7.27e-07)|COAD - Colon adenocarcinoma(8;5.15e-05)		CAGACGGCCCCAGGCATCGCG	0.731		17							Uveal_Melanoma_Familial|Familial_Malignant_Melanoma_and_Tumors_of_the_Nervous_System|Hereditary_Melanoma	HNSCC(2;<9.43e_08)|TSP Lung(5;3.83e-07)			26	7					0	0	0	0
FAM75A6	389730	broad.mit.edu	37	9	43628678	43628678	+	Silent	SNP	C	C	G			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr9:43628678C>G	uc011lrb.1	-	3	293	c.264G>C	c.(262-264)CCG>CCC	p.P88P		NM_001145196	NP_001138668	Q5VVP1	F75A6_HUMAN	hypothetical protein LOC389730	88						integral to membrane					0						CCAGGCCTCTCGGGCACTCTC	0.587		NA											30	21					0	0	0	0
GNAQ	2776	broad.mit.edu	37	9	80537224	80537224	+	Silent	SNP	C	C	T			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr9:80537224C>T	uc004akw.2	-	2	215	c.174G>A	c.(172-174)CAG>CAA	p.Q58Q		NM_002072	NP_002063	P50148	GNAQ_HUMAN	guanine nucleotide binding protein (G protein),	58					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity by dopamine receptor signaling pathway|glutamate signaling pathway|negative regulation of protein kinase activity|platelet activation|protein ADP-ribosylation|protein stabilization|regulation of action potential|regulation of catenin import into nucleus	cytoplasm|heterotrimeric G-protein complex	G-protein beta/gamma-subunit complex binding|G-protein-coupled receptor binding|GTP binding|GTPase activator activity|GTPase activity|signal transducer activity			eye(136)|skin(44)|meninges(11)|ovary(1)|kidney(1)	193						TGATTCTCATCTGCTTGATAA	0.463		NA	Mis		uveal melanoma								66	82					0	0	0	0
COL27A1	85301	broad.mit.edu	37	9	117015171	117015171	+	Missense_Mutation	SNP	A	A	C			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr9:117015171A>C	uc011lxl.1	+	27	3100	c.3100A>C	c.(3100-3102)ATG>CTG	p.M1034L	COL27A1_uc004bii.2_RNA	NM_032888	NP_116277	Q8IZC6	CORA1_HUMAN	collagen, type XXVII, alpha 1 precursor	1034	Pro-rich.|Collagen-like 7.|Triple-helical region.				cell adhesion		extracellular matrix structural constituent			ovary(3)|skin(1)	4						TCATCCTGGAATGCCAGGTGG	0.552		NA											21	31					0	0	0	0
TNC	3371	broad.mit.edu	37	9	117797486	117797486	+	Silent	SNP	G	G	C			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr9:117797486G>C	uc004bjj.3	-	22	6146	c.5784C>G	c.(5782-5784)GTC>GTG	p.V1928V	TNC_uc010mvf.2_Silent_p.V1655V	NM_002160	NP_002151	P24821	TENA_HUMAN	tenascin C precursor	1928	Fibronectin type-III 15.				cell adhesion|response to wounding|signal transduction	extracellular space	receptor binding|syndecan binding			central_nervous_system(4)|upper_aerodigestive_tract(1)|ovary(1)|skin(1)	7						AAAATACCTTGACTGTGCCAT	0.468		NA											8	73					0	0	0	0
CDK5RAP2	55755	broad.mit.edu	37	9	123169396	123169396	+	Silent	SNP	G	G	C			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr9:123169396G>C	uc004bkf.2	-	32	5038	c.4857C>G	c.(4855-4857)CTC>CTG	p.L1619L	CDK5RAP2_uc010mvi.2_Silent_p.L628L|CDK5RAP2_uc004bke.2_Silent_p.L904L|CDK5RAP2_uc004bkg.2_Intron|CDK5RAP2_uc011lxw.1_Silent_p.L884L|CDK5RAP2_uc011lxx.1_RNA|CDK5RAP2_uc011lxy.1_RNA|CDK5RAP2_uc011lxz.1_Silent_p.L884L|CDK5RAP2_uc011lya.1_Silent_p.L884L|CDK5RAP2_uc004bkh.1_Silent_p.L1389L|CDK5RAP2_uc004bki.2_3'UTR	NM_018249	NP_060719	Q96SN8	CK5P2_HUMAN	CDK5 regulatory subunit associated protein 2	1619					brain development|centrosome organization|chromosome segregation|G2/M transition of mitotic cell cycle|microtubule bundle formation|negative regulation of centriole replication|positive regulation of transcription, DNA-dependent|regulation of neuron differentiation|regulation of spindle checkpoint	cytosol|Golgi apparatus|microtubule|pericentriolar material|perinuclear region of cytoplasm|spindle pole	calmodulin binding|microtubule binding|neuronal Cdc2-like kinase binding|transcription regulatory region DNA binding			ovary(2)|lung(1)|skin(1)	4						GCTGTTCCTTGAGCCTGCTCT	0.592		NA											18	56					0	0	0	0
PTGS1	5742	broad.mit.edu	37	9	125154519	125154519	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr9:125154519C>T	uc004bmg.1	+	11	1631	c.1496C>T	c.(1495-1497)GCG>GTG	p.A499V	PTGS1_uc011lys.1_Missense_Mutation_p.A437V|PTGS1_uc010mwb.1_Missense_Mutation_p.A353V|PTGS1_uc004bmf.1_Missense_Mutation_p.A462V|PTGS1_uc004bmh.1_Missense_Mutation_p.A390V|PTGS1_uc011lyt.1_Missense_Mutation_p.A390V	NM_000962	NP_000953	P23219	PGH1_HUMAN	prostaglandin-endoperoxide synthase 1 isoform 1	499					cyclooxygenase pathway|hormone biosynthetic process|regulation of blood pressure|response to oxidative stress|xenobiotic metabolic process	endoplasmic reticulum membrane|Golgi apparatus|microsome|plasma membrane	heme binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|peroxidase activity|prostaglandin-endoperoxide synthase activity			ovary(1)|skin(1)	2					Acetaminophen(DB00316)|Aspirin(DB00945)|Balsalazide(DB01014)|Bromfenac(DB00963)|Ciclopirox(DB01188)|Diclofenac(DB00586)|Diflunisal(DB00861)|Dipyrone(DB04817)|Etodolac(DB00749)|Fenoprofen(DB00573)|Flurbiprofen(DB00712)|gamma-Homolinolenic acid(DB00154)|Ibuprofen(DB01050)|Icosapent(DB00159)|Indomethacin(DB00328)|Ketoprofen(DB01009)|Ketorolac(DB00465)|Lumiracoxib(DB01283)|Meclofenamic acid(DB00939)|Mefenamic acid(DB00784)|Mesalazine(DB00244)|Minoxidil(DB00350)|Nabumetone(DB00461)|Naproxen(DB00788)|Phenacetin(DB03783)|Piroxicam(DB00554)|Rofecoxib(DB00533)|Salicyclic acid(DB00936)|Salsalate(DB01399)|Sulindac(DB00605)|Suprofen(DB00870)|Tenoxicam(DB00469)|Tolmetin(DB00500)	GACATTGATGCGTTGGAGTTC	0.468		NA											5	57					0	0	0	0
GOLGA2	2801	broad.mit.edu	37	9	131022404	131022404	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr9:131022404C>G	uc011maw.1	-	18	1755	c.1742G>C	c.(1741-1743)GGA>GCA	p.G581A	GOLGA2_uc010mxw.2_Intron|GOLGA2_uc004buh.2_Missense_Mutation_p.G54A	NM_004486	NP_004477	Q08379	GOGA2_HUMAN	Golgi autoantigen, golgin subfamily a, 2	581	Potential.					Golgi cisterna membrane	protein binding			ovary(1)	1						CAGCTTCTTTCCCAGCTCCCT	0.612		NA											7	124					0	0	0	0
NUP188	23511	broad.mit.edu	37	9	131745290	131745290	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr9:131745290C>G	uc004bws.1	+	17	1801	c.1779C>G	c.(1777-1779)ATC>ATG	p.I593M	NUP188_uc004bwu.2_5'Flank	NM_015354	NP_056169	Q5SRE5	NU188_HUMAN	nucleoporin 188kDa	593					carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear pore	protein binding			ovary(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)|kidney(1)|breast(1)	7						CATCTCGCATCTACATGCTGC	0.532		NA											40	65					0	0	0	0
SETX	23064	broad.mit.edu	37	9	135204799	135204799	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr9:135204799C>G	uc004cbk.2	-	10	2369	c.2186G>C	c.(2185-2187)AGA>ACA	p.R729T	SETX_uc004cbj.2_Missense_Mutation_p.R348T|SETX_uc010mzt.2_Missense_Mutation_p.R348T	NM_015046	NP_055861	Q7Z333	SETX_HUMAN	senataxin	729					cell death|double-strand break repair|RNA processing	cytoplasm|nucleolus|nucleoplasm	ATP binding|DNA helicase activity			ovary(2)|skin(1)	3		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;6.82e-06)|Epithelial(140;0.000171)		TGGACCATTTCTTGAAGTACA	0.363		NA											9	106					0	0	0	0
FAM9B	171483	broad.mit.edu	37	X	8995923	8995923	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chrX:8995923C>G	uc011mhu.1	-	6	567	c.478G>C	c.(478-480)GAC>CAC	p.D160H	FAM9B_uc011mhv.1_RNA|FAM9B_uc004csh.2_Missense_Mutation_p.D200H	NM_205849	NP_995321	Q8IZU0	FAM9B_HUMAN	family with sequence similarity 9, member B	160						nucleus					0		Hepatocellular(5;0.219)				ACGAATTGGTCACGTAGCAGC	0.358		NA											4	30					0	0	0	0
CXorf21	80231	broad.mit.edu	37	X	30578057	30578057	+	Nonsense_Mutation	SNP	G	G	T			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chrX:30578057G>T	uc004dcg.1	-	3	692	c.416C>A	c.(415-417)TCA>TAA	p.S139*		NM_025159	NP_079435	Q9HAI6	CX021_HUMAN	hypothetical protein LOC80231	139										ovary(1)	1						TGTTGTCACTGAATTAATGGC	0.433		NA											36	9					4.23e-30	4.56e-30	1	0
AR	367	broad.mit.edu	37	X	66905872	66905872	+	Missense_Mutation	SNP	G	G	A	rs137852569		TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chrX:66905872G>A	uc004dwu.1	+	3	2904	c.1789G>A	c.(1789-1791)GCC>ACC	p.A597T	AR_uc011mpd.1_Missense_Mutation_p.A597T|AR_uc011mpe.1_RNA|AR_uc011mpf.1_Missense_Mutation_p.A597T|AR_uc004dwv.1_Missense_Mutation_p.A65T	NM_000044	NP_000035	P10275	ANDR_HUMAN	androgen receptor isoform 1	596	NR C4-type.|Interaction with HIPK3 (By similarity).|Nuclear receptor.		A -> T (in AIS; abolishes dimerization).		cell death|cell growth|cell proliferation|cell-cell signaling|negative regulation of apoptosis|negative regulation of integrin biosynthetic process|positive regulation of cell proliferation|positive regulation of integrin biosynthetic process|positive regulation of NF-kappaB transcription factor activity|positive regulation of phosphorylation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase III promoter|regulation of establishment of protein localization in plasma membrane|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|transport	cytoplasm|nuclear chromatin|nucleoplasm	androgen binding|androgen receptor activity|beta-catenin binding|enzyme binding|ligand-regulated transcription factor activity|protein dimerization activity|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription regulatory region DNA binding|zinc ion binding			ovary(3)|lung(2)|breast(2)|central_nervous_system(1)	8	all_cancers(1;0.173)|Prostate(1;2.27e-16)|all_epithelial(1;0.102)	all_lung(315;1.3e-11)			Bicalutamide(DB01128)|Cyproterone(DB04839)|Dromostanolone(DB00858)|Finasteride(DB01216)|Fluoxymesterone(DB01185)|Flutamide(DB00499)|Nandrolone(DB00984)|Nilutamide(DB00665)|Oxandrolone(DB00621)|Testosterone(DB00624)	GTACCTGTGCGCCAGCAGAAA	0.413		NA							Androgen_Insensitivity_Syndrome				3	33					0	0	0	0
KIAA2022	340533	broad.mit.edu	37	X	73964209	73964209	+	Silent	SNP	G	G	A			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chrX:73964209G>A	uc004eby.2	-	3	800	c.183C>T	c.(181-183)CCC>CCT	p.P61P		NM_001008537	NP_001008537	Q5QGS0	K2022_HUMAN	hypothetical protein LOC340533	61					base-excision repair, gap-filling|DNA replication proofreading|DNA replication, removal of RNA primer|nucleotide-excision repair, DNA gap filling|regulation of mitotic cell cycle|S phase of mitotic cell cycle	delta DNA polymerase complex	3'-5'-exodeoxyribonuclease activity|DNA-directed DNA polymerase activity			ovary(7)|large_intestine(4)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	15						GGAGACCTCTGGGATACATCA	0.537		NA											3	9					0	0	0	0
PKN1	5585	broad.mit.edu	37	19	14562741	14562741	+	Frame_Shift_Del	DEL	C	C	-			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr19:14562741delC	uc002myp.2	+	7	1239	c.1071delC	c.(1069-1071)CGCfs	p.R357fs	PKN1_uc002myq.2_Frame_Shift_Del_p.R363fs	NM_002741	NP_002732	Q16512	PKN1_HUMAN	protein kinase N1 isoform 2	357	C2.				activation of JUN kinase activity|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|transcription, DNA-dependent	endosome|nucleus|plasma membrane	androgen receptor binding|ATP binding|chromatin binding|GTP-Rho binding|histone binding|histone deacetylase binding|histone kinase activity (H3-T11 specific)|ligand-dependent nuclear receptor transcription coactivator activity|protein kinase C activity|protein kinase C binding|Rac GTPase binding			ovary(2)|breast(2)|skin(2)|large_intestine(1)|central_nervous_system(1)	8						CAGACAGCCGCCCCCCCTTCC	0.667		NA											11	10	---	---	---	---	NA	NA	NA	NA
FAT1	2195	broad.mit.edu	37	4	187539265	187539266	+	Frame_Shift_Ins	INS	-	-	C			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr4:187539265_187539266insC	uc003izf.2	-	10	8662_8663	c.8474_8475insG	c.(8473-8475)GGAfs	p.G2825fs		NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor	2825	Extracellular (Potential).|Cadherin 26.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12						TTACTCTACTTCCCCCTGGCAG	0.436		NA								HNSCC(5;0.00058)			29	24	---	---	---	---	NA	NA	NA	NA