Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	isArtifactMode	oxoGCut
CASZ1	54897	broad.mit.edu	37	1	10699678	10699678	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7416-01A-11D-2078-08	TCGA-CV-7416-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	80c86be4-ccbe-4bf5-afcf-644cd337d37a	061150b2-1c4a-4126-9e7c-e9088d04db80	g.chr1:10699678C>T	uc001aro.2	-	21	4921	c.4601G>A	c.(4600-4602)CGC>CAC	p.R1534H		NM_001079843	NP_001073312	Q86V15	CASZ1_HUMAN	castor homolog 1, zinc finger isoform a	1534	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			skin(1)	1	Ovarian(185;0.203)|all_lung(157;0.204)	Lung NSC(185;4.96e-06)|all_lung(284;1.22e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00212)|Hepatocellular(190;0.00913)|Ovarian(437;0.0229)|Myeloproliferative disorder(586;0.0255)	STAD - Stomach adenocarcinoma(5;0.0224)	UCEC - Uterine corpus endometrioid carcinoma (279;0.0265)|Colorectal(212;3.54e-08)|COAD - Colon adenocarcinoma(227;9.56e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000219)|Kidney(185;0.00142)|KIRC - Kidney renal clear cell carcinoma(229;0.00381)|READ - Rectum adenocarcinoma(331;0.0419)|STAD - Stomach adenocarcinoma(132;0.0623)		GTGGTGCTTGCGATGCGCCGT	0.662		NA											5	7					0	0	0	0
PADI4	23569	broad.mit.edu	37	1	17682852	17682853	+	Missense_Mutation	DNP	GG	GG	AT			TCGA-CV-7416-01A-11D-2078-08	TCGA-CV-7416-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	80c86be4-ccbe-4bf5-afcf-644cd337d37a	061150b2-1c4a-4126-9e7c-e9088d04db80	g.chr1:17682852_17682853GG>AT	uc001baj.2	+	13	1484_1485	c.1456_1457GG>AT	c.(1456-1458)GGC>ATC	p.G486I		NM_012387	NP_036519	Q9UM07	PADI4_HUMAN	peptidyl arginine deiminase, type IV	486					chromatin modification|peptidyl-citrulline biosynthetic process from peptidyl-arginine|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	calcium ion binding|protein-arginine deiminase activity			ovary(1)|skin(1)	2		Colorectal(325;3.46e-05)|Breast(348;0.000162)|all_lung(284;0.000338)|Lung NSC(340;0.00042)|Renal(390;0.000518)|Ovarian(437;0.00409)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00537)|BRCA - Breast invasive adenocarcinoma(304;8.54e-06)|COAD - Colon adenocarcinoma(227;1.33e-05)|Kidney(64;0.000223)|KIRC - Kidney renal clear cell carcinoma(64;0.00313)|STAD - Stomach adenocarcinoma(196;0.00707)|READ - Rectum adenocarcinoma(331;0.0689)|Lung(427;0.199)	L-Citrulline(DB00155)	CTGCCTCCAGGGCTTCCGGCTG	0.609		NA											3	21					0	0	0	0
UBR4	23352	broad.mit.edu	37	1	19487581	19487581	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CV-7416-01A-11D-2078-08	TCGA-CV-7416-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	80c86be4-ccbe-4bf5-afcf-644cd337d37a	061150b2-1c4a-4126-9e7c-e9088d04db80	g.chr1:19487581G>A	uc001bbi.2	-	38	5240	c.5236C>T	c.(5236-5238)CAG>TAG	p.Q1746*	UBR4_uc001bbm.1_Nonsense_Mutation_p.Q957*	NM_020765	NP_065816	Q5T4S7	UBR4_HUMAN	retinoblastoma-associated factor 600	1746					interspecies interaction between organisms	cytoplasm|cytoskeleton|integral to membrane|nucleus	calmodulin binding|ubiquitin-protein ligase activity|zinc ion binding			kidney(10)|ovary(7)|breast(4)|pancreas(2)|skin(2)	25		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000328)|Lung NSC(340;0.000406)|Breast(348;0.000814)|Ovarian(437;0.00774)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00674)|BRCA - Breast invasive adenocarcinoma(304;5.43e-05)|Kidney(64;0.000337)|KIRC - Kidney renal clear cell carcinoma(64;0.00426)|STAD - Stomach adenocarcinoma(196;0.00715)|READ - Rectum adenocarcinoma(331;0.0816)		GGTTCACTCTGAAATGCCGAC	0.512		NA											3	23					0	0	0	0
GJA9	81025	broad.mit.edu	37	1	39341347	39341347	+	Silent	SNP	T	T	G			TCGA-CV-7416-01A-11D-2078-08	TCGA-CV-7416-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	80c86be4-ccbe-4bf5-afcf-644cd337d37a	061150b2-1c4a-4126-9e7c-e9088d04db80	g.chr1:39341347T>G	uc001cct.1	-	2	705	c.424A>C	c.(424-426)AGG>CGG	p.R142R	RRAGC_uc001ccr.2_5'Flank|MYCBP_uc001ccs.2_5'Flank	NM_030772	NP_110399	P57773	CXA9_HUMAN	gap junction protein, alpha 9, 59kDa	142	Cytoplasmic (Potential).				cell communication	connexon complex|integral to membrane					0	Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0393)	OV - Ovarian serous cystadenocarcinoma(33;8.23e-17)			TTTAGTTTCCTTTTCTCCAGC	0.433		NA											26	51					0	0	0	0
MSH4	4438	broad.mit.edu	37	1	76269464	76269464	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7416-01A-11D-2078-08	TCGA-CV-7416-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	80c86be4-ccbe-4bf5-afcf-644cd337d37a	061150b2-1c4a-4126-9e7c-e9088d04db80	g.chr1:76269464C>T	uc001dhd.1	+	2	334	c.293C>T	c.(292-294)TCA>TTA	p.S98L		NM_002440	NP_002431	O15457	MSH4_HUMAN	mutS homolog 4	98					chiasma assembly|homologous chromosome segregation|mismatch repair|reciprocal meiotic recombination	synaptonemal complex	ATP binding|DNA-dependent ATPase activity|mismatched DNA binding			lung(3)|ovary(2)	5						ACAGTTGCATCAAATTTTACT	0.328		NA						MMR					5	39					0	0	0	0
IGSF8	93185	broad.mit.edu	37	1	160062266	160062266	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7416-01A-11D-2078-08	TCGA-CV-7416-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	80c86be4-ccbe-4bf5-afcf-644cd337d37a	061150b2-1c4a-4126-9e7c-e9088d04db80	g.chr1:160062266C>T	uc001fva.2	-	5	1577	c.1532G>A	c.(1531-1533)CGG>CAG	p.R511Q	IGSF8_uc001fuz.2_Missense_Mutation_p.R511Q|IGSF8_uc009wtf.2_Missense_Mutation_p.R511Q	NM_052868	NP_443100	Q969P0	IGSF8_HUMAN	immunoglobulin superfamily, member 8	511	Ig-like C2-type 4.|Extracellular (Potential).				cell proliferation|cellular component movement|nervous system development|single fertilization|skeletal muscle tissue development	integral to membrane	protein binding				0	all_cancers(52;1.11e-16)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)|LUSC - Lung squamous cell carcinoma(543;0.246)			TCCTCCAGGCCGGACTCCCAG	0.662		NA											5	19					0	0	0	0
PFDN2	5202	broad.mit.edu	37	1	161071851	161071851	+	Missense_Mutation	SNP	T	T	C			TCGA-CV-7416-01A-11D-2078-08	TCGA-CV-7416-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	80c86be4-ccbe-4bf5-afcf-644cd337d37a	061150b2-1c4a-4126-9e7c-e9088d04db80	g.chr1:161071851T>C	uc001fxu.2	-	3	325	c.275A>G	c.(274-276)AAC>AGC	p.N92S		NM_012394	NP_036526	Q9UHV9	PFD2_HUMAN	prefoldin subunit 2	92					'de novo' posttranslational protein folding	prefoldin complex	unfolded protein binding				0	all_cancers(52;1.84e-19)|Breast(13;0.00188)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00165)			CTCCTTGTTGTTCTCCAAAGC	0.343		NA											6	22					0	0	0	0
SOX13	9580	broad.mit.edu	37	1	204085788	204085788	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7416-01A-11D-2078-08	TCGA-CV-7416-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	80c86be4-ccbe-4bf5-afcf-644cd337d37a	061150b2-1c4a-4126-9e7c-e9088d04db80	g.chr1:204085788C>T	uc001ham.2	+	5	1167	c.572C>T	c.(571-573)GCC>GTC	p.A191V	SOX13_uc001hal.2_Missense_Mutation_p.A191V|SOX13_uc010pqp.1_Missense_Mutation_p.A191V|SOX13_uc010pqq.1_Missense_Mutation_p.A58V	NM_005686	NP_005677	Q9UN79	SOX13_HUMAN	SRY-box 13	191	Gln-rich.				anatomical structure morphogenesis	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|central_nervous_system(1)	2	all_cancers(21;0.0754)|Breast(84;0.116)|all_epithelial(62;0.189)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.109)			ATGGAGCTTGCCCGGCAGCAG	0.587		NA											3	38					0	0	0	0
FBXO18	84893	broad.mit.edu	37	10	5951214	5951214	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7416-01A-11D-2078-08	TCGA-CV-7416-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	80c86be4-ccbe-4bf5-afcf-644cd337d37a	061150b2-1c4a-4126-9e7c-e9088d04db80	g.chr10:5951214C>T	uc001iis.2	+	5	1072	c.977C>T	c.(976-978)GCG>GTG	p.A326V	FBXO18_uc001iir.2_Missense_Mutation_p.A252V|FBXO18_uc009xig.2_Missense_Mutation_p.A252V|FBXO18_uc001iit.2_Missense_Mutation_p.A377V	NM_178150	NP_835363	Q8NFZ0	FBX18_HUMAN	F-box only protein, helicase, 18 isoform 2	326					DNA repair	nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding			ovary(2)|skin(1)	3						GAGGCTGAGGCGTGTGTGCGG	0.612		NA											11	19					0	0	0	0
KIAA1462	57608	broad.mit.edu	37	10	30317939	30317939	+	Missense_Mutation	SNP	C	C	A			TCGA-CV-7416-01A-11D-2078-08	TCGA-CV-7416-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	80c86be4-ccbe-4bf5-afcf-644cd337d37a	061150b2-1c4a-4126-9e7c-e9088d04db80	g.chr10:30317939C>A	uc001iux.2	-	2	1197	c.1138G>T	c.(1138-1140)GCT>TCT	p.A380S	KIAA1462_uc001iuy.2_Intron|KIAA1462_uc001iuz.2_Missense_Mutation_p.A242S|KIAA1462_uc009xle.1_Missense_Mutation_p.A380S	NM_020848	NP_065899	Q9P266	K1462_HUMAN	hypothetical protein LOC57608	380	Pro-rich.									ovary(4)	4						CTGGCCCCAGCCTTCTCGGTC	0.632		NA											7	90					8.13e-05	8.79e-05	1	0
COL17A1	1308	broad.mit.edu	37	10	105812854	105812854	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7416-01A-11D-2078-08	TCGA-CV-7416-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	80c86be4-ccbe-4bf5-afcf-644cd337d37a	061150b2-1c4a-4126-9e7c-e9088d04db80	g.chr10:105812854C>T	uc001kxr.2	-	23	2043	c.1874G>A	c.(1873-1875)CGA>CAA	p.R625Q	COL17A1_uc010qqv.1_Missense_Mutation_p.R609Q	NM_000494	NP_000485	Q9UMD9	COHA1_HUMAN	alpha 1 type XVII collagen	625	Extracellular (Potential).|Triple-helical region.				cell-matrix adhesion|epidermis development|hemidesmosome assembly	basement membrane|cell-cell junction|collagen|hemidesmosome|integral to plasma membrane	protein binding			ovary(4)|pancreas(1)	5		Colorectal(252;0.103)|Breast(234;0.122)		Epithelial(162;2.5e-09)|all cancers(201;7.94e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0165)		GGGGCCTTCTCGCCCTCTCTG	0.597		NA											34	50					0	0	0	0
ADAM12	8038	broad.mit.edu	37	10	127786990	127786990	+	Missense_Mutation	SNP	C	C	A			TCGA-CV-7416-01A-11D-2078-08	TCGA-CV-7416-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	80c86be4-ccbe-4bf5-afcf-644cd337d37a	061150b2-1c4a-4126-9e7c-e9088d04db80	g.chr10:127786990C>A	uc001ljk.2	-	10	1413	c.1000G>T	c.(1000-1002)GTC>TTC	p.V334F	ADAM12_uc010qul.1_Missense_Mutation_p.V285F|ADAM12_uc001ljm.2_Missense_Mutation_p.V334F|ADAM12_uc001ljn.2_Missense_Mutation_p.V331F|ADAM12_uc001ljl.3_Missense_Mutation_p.V331F	NM_003474	NP_003465	O43184	ADA12_HUMAN	ADAM metallopeptidase domain 12 isoform 1	334	Extracellular (Potential).|Peptidase M12B.				cell adhesion|epidermal growth factor receptor signaling pathway|myoblast fusion|proteolysis	extracellular region|integral to membrane|plasma membrane	metalloendopeptidase activity|protein binding|SH3 domain binding|zinc ion binding			breast(4)|ovary(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	9		all_epithelial(44;7.06e-05)|all_lung(145;0.00563)|Lung NSC(174;0.00834)|Colorectal(57;0.102)|all_neural(114;0.107)|Breast(234;0.22)		COAD - Colon adenocarcinoma(40;0.141)|Colorectal(40;0.216)		CTTACCATGACAATTCCCCCA	0.483		NA											43	75					2.02e-29	2.29e-29	1	0
OR51I1	390063	broad.mit.edu	37	11	5461808	5461808	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7416-01A-11D-2078-08	TCGA-CV-7416-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	80c86be4-ccbe-4bf5-afcf-644cd337d37a	061150b2-1c4a-4126-9e7c-e9088d04db80	g.chr11:5461808G>C	uc010qze.1	-	1	937	c.937C>G	c.(937-939)CAG>GAG	p.Q313E	HBG2_uc001mak.1_Intron|HBE1_uc001mam.1_Intron|OR51B5_uc001maq.1_Intron	NM_001005288	NP_001005288	Q9H343	O51I1_HUMAN	olfactory receptor, family 51, subfamily I,	313	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;1.92e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CCTCAGGCCTGGGATTTATGG	0.463		NA											7	34					0	0	0	0
KCNC1	3746	broad.mit.edu	37	11	17793574	17793574	+	Silent	SNP	C	C	T	rs76882721	byFrequency	TCGA-CV-7416-01A-11D-2078-08	TCGA-CV-7416-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	80c86be4-ccbe-4bf5-afcf-644cd337d37a	061150b2-1c4a-4126-9e7c-e9088d04db80	g.chr11:17793574C>T	uc001mnk.3	+	2	988	c.933C>T	c.(931-933)CGC>CGT	p.R311R	KCNC1_uc009yhc.1_Silent_p.R311R	NM_004976	NP_004967	P48547	KCNC1_HUMAN	Shaw-related voltage-gated potassium channel	311	Helical; Voltage-sensor; Name=Segment S4; (Potential).					voltage-gated potassium channel complex	voltage-gated potassium channel activity			upper_aerodigestive_tract(1)	1						GCTTCCTGCGCGTCGTCCGCT	0.627		NA											3	19					0	0	0	0
HTATIP2	10553	broad.mit.edu	37	11	20404742	20404742	+	Silent	SNP	C	C	G			TCGA-CV-7416-01A-11D-2078-08	TCGA-CV-7416-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	80c86be4-ccbe-4bf5-afcf-644cd337d37a	061150b2-1c4a-4126-9e7c-e9088d04db80	g.chr11:20404742C>G	uc009yia.1	+	6	786	c.720C>G	c.(718-720)CTC>CTG	p.L240L	HTATIP2_uc009yib.1_Silent_p.L240L|HTATIP2_uc001mpx.2_Silent_p.L274L|HTATIP2_uc001mpz.2_Silent_p.L240L	NM_006410	NP_006401	Q9BUP3	HTAI2_HUMAN	HIV-1 Tat interactive protein 2, 30kDa isoform	240					angiogenesis|anti-apoptosis|apoptosis|cell differentiation|cellular amino acid metabolic process|induction of apoptosis|interspecies interaction between organisms|nuclear import|regulation of angiogenesis|regulation of transcription from RNA polymerase II promoter	cytoplasm|nuclear envelope	NAD binding|oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor|protein binding|transcription coactivator activity				0						ATGGCTCTCTCAAGCCATGAC	0.443		NA											4	5					0	0	0	0
OR8H3	390152	broad.mit.edu	37	11	55890111	55890111	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7416-01A-11D-2078-08	TCGA-CV-7416-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	80c86be4-ccbe-4bf5-afcf-644cd337d37a	061150b2-1c4a-4126-9e7c-e9088d04db80	g.chr11:55890111C>T	uc001nii.1	+	1	263	c.263C>T	c.(262-264)ACT>ATT	p.T88I		NM_001005201	NP_001005201	Q8N146	OR8H3_HUMAN	olfactory receptor, family 8, subfamily H,	88	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	Esophageal squamous(21;0.00693)					AACTTACTGACTTCCAACTAT	0.423		NA											69	290					0	0	0	0
PGA5	5222	broad.mit.edu	37	11	61018663	61018663	+	Missense_Mutation	SNP	G	G	T			TCGA-CV-7416-01A-11D-2078-08	TCGA-CV-7416-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	80c86be4-ccbe-4bf5-afcf-644cd337d37a	061150b2-1c4a-4126-9e7c-e9088d04db80	g.chr11:61018663G>T	uc001nqz.2	+	9	1107	c.1077G>T	c.(1075-1077)GAG>GAT	p.E359D		NM_014224	NP_055039	P00790	PEPA_HUMAN	pepsinogen 5, group I precursor	359					digestion|proteolysis	extracellular region	aspartic-type endopeptidase activity			skin(1)	1						AATCTGGAGAGCTTTGGATCC	0.552		NA											31	139					4.63e-21	5.2e-21	1	0
OR9K2	441639	broad.mit.edu	37	12	55523868	55523868	+	Missense_Mutation	SNP	G	G	T			TCGA-CV-7416-01A-11D-2078-08	TCGA-CV-7416-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	80c86be4-ccbe-4bf5-afcf-644cd337d37a	061150b2-1c4a-4126-9e7c-e9088d04db80	g.chr12:55523868G>T	uc010spe.1	+	1	316	c.316G>T	c.(316-318)GCT>TCT	p.A106S		NM_001005243	NP_001005243	Q8NGE7	OR9K2_HUMAN	olfactory receptor, family 9, subfamily K,	106	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|pancreas(1)	2						TGAACCCAAGGCTATGATCAA	0.423		NA											19	70					2.35e-11	2.57e-11	1	0
ORAI1	84876	broad.mit.edu	37	12	122079507	122079507	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7416-01A-11D-2078-08	TCGA-CV-7416-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	80c86be4-ccbe-4bf5-afcf-644cd337d37a	061150b2-1c4a-4126-9e7c-e9088d04db80	g.chr12:122079507C>G	uc010szz.1	+	3	1057	c.864C>G	c.(862-864)CAC>CAG	p.H288Q		NM_032790	NP_116179	Q96D31	CRCM1_HUMAN	calcium release-activated calcium channel	288	Cytoplasmic (Potential).				platelet activation|positive regulation of calcium ion transport	integral to plasma membrane	protein binding|store-operated calcium channel activity				0	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)			OV - Ovarian serous cystadenocarcinoma(86;0.000415)|Epithelial(86;0.00148)		AGCTGGACCACAGAGGGGACC	0.612		NA											19	62					0	0	0	0
DGKH	160851	broad.mit.edu	37	13	42761205	42761205	+	Missense_Mutation	SNP	A	A	C			TCGA-CV-7416-01A-11D-2078-08	TCGA-CV-7416-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	80c86be4-ccbe-4bf5-afcf-644cd337d37a	061150b2-1c4a-4126-9e7c-e9088d04db80	g.chr13:42761205A>C	uc001uyl.1	+	14	1580	c.1559A>C	c.(1558-1560)AAG>ACG	p.K520T	DGKH_uc010tfh.1_Missense_Mutation_p.K520T|DGKH_uc001uym.1_Missense_Mutation_p.K520T|DGKH_uc010tfi.1_Missense_Mutation_p.K275T|DGKH_uc010tfj.1_Missense_Mutation_p.K375T|DGKH_uc001uyn.1_RNA|DGKH_uc001uyo.1_Missense_Mutation_p.K375T|DGKH_uc001uyp.2_RNA	NM_178009	NP_821077	Q86XP1	DGKH_HUMAN	diacylglycerol kinase, eta isoform 2	520					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation|protein oligomerization	endosome|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			ovary(2)	2		Lung NSC(96;1.02e-05)|Prostate(109;0.0168)|Lung SC(185;0.0262)|Breast(139;0.0709)|Hepatocellular(98;0.114)		OV - Ovarian serous cystadenocarcinoma(117;5.88e-05)|GBM - Glioblastoma multiforme(144;0.000935)|BRCA - Breast invasive adenocarcinoma(63;0.109)		GAAACTGTAAAGGACTTCGTT	0.373		NA											14	51					0	0	0	0
NRXN3	9369	broad.mit.edu	37	14	80164200	80164200	+	Missense_Mutation	SNP	A	A	C			TCGA-CV-7416-01A-11D-2078-08	TCGA-CV-7416-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	80c86be4-ccbe-4bf5-afcf-644cd337d37a	061150b2-1c4a-4126-9e7c-e9088d04db80	g.chr14:80164200A>C	uc001xun.2	+	15	3216	c.2725A>C	c.(2725-2727)ATG>CTG	p.M909L	NRXN3_uc001xum.1_RNA|NRXN3_uc001xup.2_RNA|NRXN3_uc001xuq.2_Missense_Mutation_p.M277L|NRXN3_uc010asw.2_Missense_Mutation_p.M307L|NRXN3_uc001xur.3_Missense_Mutation_p.M277L	NM_004796	NP_004787	Q9Y4C0	NRX3A_HUMAN	neurexin 3 isoform 1 precursor	1282	Extracellular (Potential).				axon guidance|cell adhesion	integral to plasma membrane	metal ion binding|receptor activity			ovary(3)|upper_aerodigestive_tract(2)|pancreas(2)|central_nervous_system(1)|breast(1)|skin(1)	10		Renal(4;0.00876)		BRCA - Breast invasive adenocarcinoma(234;0.00544)|Kidney(3;0.029)|KIRC - Kidney renal clear cell carcinoma(182;0.223)		GCCACCAGAAATGTCTACTAC	0.453		NA											8	47					0	0	0	0
HERC2	8924	broad.mit.edu	37	15	28517376	28517376	+	Silent	SNP	G	G	A	rs141677977		TCGA-CV-7416-01A-11D-2078-08	TCGA-CV-7416-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	80c86be4-ccbe-4bf5-afcf-644cd337d37a	061150b2-1c4a-4126-9e7c-e9088d04db80	g.chr15:28517376G>A	uc001zbj.2	-	9	1174	c.1068C>T	c.(1066-1068)TCC>TCT	p.S356S	HERC2_uc001zbl.1_Silent_p.S51S	NM_004667	NP_004658	O95714	HERC2_HUMAN	hect domain and RLD 2	356					DNA repair|intracellular protein transport|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	guanyl-nucleotide exchange factor activity|heme binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(4)|lung(4)|skin(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	13		all_lung(180;1.3e-11)|Breast(32;0.000194)|Colorectal(260;0.227)		all cancers(64;3.93e-09)|Epithelial(43;9.99e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0271)|GBM - Glioblastoma multiforme(186;0.0497)|Lung(196;0.199)		TGTCGCCCTCGGAGTGGGGTG	0.527		NA											3	24					0	0	0	0
UBR1	197131	broad.mit.edu	37	15	43330042	43330042	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7416-01A-11D-2078-08	TCGA-CV-7416-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	80c86be4-ccbe-4bf5-afcf-644cd337d37a	061150b2-1c4a-4126-9e7c-e9088d04db80	g.chr15:43330042G>A	uc001zqq.2	-	17	2017	c.1951C>T	c.(1951-1953)CGT>TGT	p.R651C	UBR1_uc010udk.1_Missense_Mutation_p.R651C	NM_174916	NP_777576	Q8IWV7	UBR1_HUMAN	ubiquitin protein ligase E3 component n-recognin	651					cellular response to leucine|negative regulation of TOR signaling cascade	cytosol	leucine binding|zinc ion binding			lung(1)	1		all_cancers(109;4.32e-15)|all_epithelial(112;4.05e-13)|Lung NSC(122;1.75e-08)|all_lung(180;2e-07)|Melanoma(134;0.0179)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;4.08e-07)|COAD - Colon adenocarcinoma(120;0.185)|Colorectal(105;0.214)		ACCAGACAACGTAAAGGATAT	0.393		NA											4	22					0	0	0	0
ITGA11	22801	broad.mit.edu	37	15	68624774	68624774	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7416-01A-11D-2078-08	TCGA-CV-7416-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	80c86be4-ccbe-4bf5-afcf-644cd337d37a	061150b2-1c4a-4126-9e7c-e9088d04db80	g.chr15:68624774C>T	uc002ari.2	-	13	1555	c.1468G>A	c.(1468-1470)GAC>AAC	p.D490N	ITGA11_uc010bib.2_Missense_Mutation_p.D490N	NM_001004439	NP_001004439	Q9UKX5	ITA11_HUMAN	integrin, alpha 11 precursor	490	FG-GAP 5.|Potential.|Extracellular (Potential).				cell-matrix adhesion|integrin-mediated signaling pathway|muscle organ development	integrin complex	collagen binding|receptor activity			kidney(2)|pancreas(1)	3					Tirofiban(DB00775)	CCGTCGCCGTCGATGTCCACC	0.602		NA											6	9					0	0	0	0
C15orf27	123591	broad.mit.edu	37	15	76496314	76496314	+	Silent	SNP	G	G	A			TCGA-CV-7416-01A-11D-2078-08	TCGA-CV-7416-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	80c86be4-ccbe-4bf5-afcf-644cd337d37a	061150b2-1c4a-4126-9e7c-e9088d04db80	g.chr15:76496314G>A	uc002bbq.2	+	11	1409	c.1254G>A	c.(1252-1254)CCG>CCA	p.P418P	C15orf27_uc010bkp.2_Silent_p.P234P|C15orf27_uc002bbr.2_Silent_p.P234P|C15orf27_uc002bbs.2_Silent_p.P96P	NM_152335	NP_689548	Q2M3C6	CO027_HUMAN	hypothetical protein LOC123591	418						integral to membrane					0						GCGAGGAGCCGTCCTCTGAGC	0.701		NA											10	28					0	0	0	0
SCAPER	49855	broad.mit.edu	37	15	76957999	76957999	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7416-01A-11D-2078-08	TCGA-CV-7416-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	80c86be4-ccbe-4bf5-afcf-644cd337d37a	061150b2-1c4a-4126-9e7c-e9088d04db80	g.chr15:76957999G>C	uc002bby.2	-	20	2699	c.2640C>G	c.(2638-2640)AAC>AAG	p.N880K	SCAPER_uc010bkr.2_Missense_Mutation_p.N188K|SCAPER_uc002bbx.2_Missense_Mutation_p.N634K|SCAPER_uc002bbz.1_Missense_Mutation_p.N751K|SCAPER_uc002bca.1_Missense_Mutation_p.N745K	NM_020843	NP_065894	Q9BY12	SCAPE_HUMAN	S-phase cyclin A-associated protein in the ER	879						endoplasmic reticulum|nucleus	zinc ion binding			large_intestine(1)|lung(1)|ovary(1)	3						GGTACCTGAAGTTCATCCGGG	0.328		NA											2	3					0	0	0	0
IL16	3603	broad.mit.edu	37	15	81598782	81598782	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7416-01A-11D-2078-08	TCGA-CV-7416-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	80c86be4-ccbe-4bf5-afcf-644cd337d37a	061150b2-1c4a-4126-9e7c-e9088d04db80	g.chr15:81598782C>T	uc002bgh.3	+	18	4077	c.3701C>T	c.(3700-3702)ACG>ATG	p.T1234M	IL16_uc010blq.1_Missense_Mutation_p.T1188M|IL16_uc002bge.3_RNA|IL16_uc010unp.1_Missense_Mutation_p.T1275M|IL16_uc002bgg.2_Missense_Mutation_p.T1233M|IL16_uc002bgi.1_Missense_Mutation_p.T623M|IL16_uc002bgj.2_Missense_Mutation_p.T727M|IL16_uc002bgk.2_Missense_Mutation_p.T533M|IL16_uc002bgl.1_Missense_Mutation_p.T533M|IL16_uc010unq.1_Missense_Mutation_p.T532M	NM_172217	NP_757366	Q14005	IL16_HUMAN	interleukin 16 isoform 2	1234	PDZ 4.				immune response|interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|extracellular space|nucleus|plasma membrane	cytokine activity			ovary(2)|lung(1)|skin(1)	4						ACAGTCTGCACGGTGACACTG	0.577		NA											5	100					0	0	0	0
C15orf32	145858	broad.mit.edu	37	15	93016181	93016181	+	Splice_Site	SNP	A	A	G			TCGA-CV-7416-01A-11D-2078-08	TCGA-CV-7416-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	80c86be4-ccbe-4bf5-afcf-644cd337d37a	061150b2-1c4a-4126-9e7c-e9088d04db80	g.chr15:93016181A>G	uc002brc.1	+	2	847	c.375_splice	c.e2-2	p.R125_splice	C15orf32_uc010bod.1_Splice_Site	NM_153040	NP_694585	Q32M92	CO032_HUMAN	hypothetical protein LOC145858											ovary(1)	1	Lung NSC(78;0.0893)|all_lung(78;0.125)		BRCA - Breast invasive adenocarcinoma(143;0.0493)|OV - Ovarian serous cystadenocarcinoma(32;0.125)			TGTTTTCCACAGACACATCCT	0.493		NA											21	68					0	0	0	0
MTSS1L	92154	broad.mit.edu	37	16	70712271	70712271	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7416-01A-11D-2078-08	TCGA-CV-7416-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	80c86be4-ccbe-4bf5-afcf-644cd337d37a	061150b2-1c4a-4126-9e7c-e9088d04db80	g.chr16:70712271C>T	uc002ezj.2	-	8	768	c.508G>A	c.(508-510)GAC>AAC	p.D170N	MTSS1L_uc002ezk.1_Missense_Mutation_p.D87N	NM_138383	NP_612392	Q765P7	MTSSL_HUMAN	metastasis suppressor 1-like	170	IMD.				filopodium assembly|signal transduction		actin binding|cytoskeletal adaptor activity|SH3 domain binding			central_nervous_system(1)	1						TCGTTGACGTCCTGCAGGGCA	0.662		NA											12	46					0	0	0	0
CHST6	4166	broad.mit.edu	37	16	75512907	75512907	+	Missense_Mutation	SNP	C	C	T	rs72547538		TCGA-CV-7416-01A-11D-2078-08	TCGA-CV-7416-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	80c86be4-ccbe-4bf5-afcf-644cd337d37a	061150b2-1c4a-4126-9e7c-e9088d04db80	g.chr16:75512907C>T	uc002fef.2	-	3	1000	c.820G>A	c.(820-822)GAG>AAG	p.E274K	CHST6_uc002feg.1_RNA|CHST6_uc002feh.1_Missense_Mutation_p.E274K	NM_021615	NP_067628	Q9GZX3	CHST6_HUMAN	carbohydrate (N-acetylglucosamine 6-O)	274	Lumenal (Potential).		E -> K (in MCD; abolishes ability to sulfate keratan).		keratan sulfate biosynthetic process|N-acetylglucosamine metabolic process	Golgi membrane|integral to membrane	N-acetylglucosamine 6-O-sulfotransferase activity				0						GCCAGGTCCTCGAAGCGCACC	0.672		NA											5	60					0	0	0	0
CNTNAP4	85445	broad.mit.edu	37	16	76513352	76513352	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7416-01A-11D-2078-08	TCGA-CV-7416-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	80c86be4-ccbe-4bf5-afcf-644cd337d37a	061150b2-1c4a-4126-9e7c-e9088d04db80	g.chr16:76513352G>A	uc002feu.1	+	14	2184	c.1799G>A	c.(1798-1800)AGA>AAA	p.R600K	CNTNAP4_uc002fev.1_Missense_Mutation_p.R464K|CNTNAP4_uc010chb.1_Missense_Mutation_p.R527K|CNTNAP4_uc002fex.1_Missense_Mutation_p.R603K|CNTNAP4_uc002few.2_Missense_Mutation_p.R575K	NM_033401	NP_207837	Q9C0A0	CNTP4_HUMAN	cell recognition protein CASPR4 isoform 1	600	Extracellular (Potential).|Fibrinogen C-terminal.				cell adhesion|signal transduction	integral to membrane	receptor binding			ovary(1)|pancreas(1)	2						TATAAGCACAGAGGAAATACT	0.343		NA											16	81					0	0	0	0
TP53	7157	broad.mit.edu	37	17	7578406	7578406	+	Missense_Mutation	SNP	C	C	T	rs28934578		TCGA-CV-7416-01A-11D-2078-08	TCGA-CV-7416-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	80c86be4-ccbe-4bf5-afcf-644cd337d37a	061150b2-1c4a-4126-9e7c-e9088d04db80	g.chr17:7578406C>T	uc002gim.2	-	5	718	c.524G>A	c.(523-525)CGC>CAC	p.R175H	TP53_uc002gig.1_Missense_Mutation_p.R175H|TP53_uc002gih.2_Missense_Mutation_p.R175H|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.R43H|TP53_uc010cng.1_Missense_Mutation_p.R43H|TP53_uc002gii.1_Missense_Mutation_p.R43H|TP53_uc010cnh.1_Missense_Mutation_p.R175H|TP53_uc010cni.1_Missense_Mutation_p.R175H|TP53_uc002gij.2_Missense_Mutation_p.R175H|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.R82H|TP53_uc002gio.2_Missense_Mutation_p.R43H|TP53_uc010vug.1_Missense_Mutation_p.R136H	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	175	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		R -> L (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> Q (in a sporadic cancer; somatic mutation).|R -> P (in sporadic cancers; somatic mutation).|R -> G (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> C (in sporadic cancers; somatic mutation).|R -> S (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R175H(729)|p.R175L(19)|p.R175C(12)|p.R175G(11)|p.0?(7)|p.R175P(5)|p.R175S(5)|p.R43H(5)|p.R82H(5)|p.R175R(4)|p.R174fs*24(3)|p.R175_E180delRCPHHE(3)|p.R175fs*5(2)|p.V173fs*59(2)|p.R174fs*1(2)|p.V157_C176del20(1)|p.K164_P219del(1)|p.V173fs*69(1)|p.E171fs*61(1)|p.V173fs*23(1)|p.R174_H178>S(1)|p.V172_E180delVVRRCPHHE(1)|p.R174_H179delRRCPHH(1)|p.E171fs*1(1)|p.R175_H178>X(1)|p.R175fs*6(1)|p.R42fs*24(1)|p.R174_C176delRRC(1)|p.H168fs*69(1)|p.R175fs*72(1)|p.R174fs*70(1)|p.E171_H179delEVVRRCPHH(1)|p.R81fs*24(1)|p.R174_E180>K(1)|p.R174fs*3(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GTGGGGGCAGCGCCTCACAAC	0.652	R175H(KMS26_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R175H(HCC1395_BREAST)|R175H(KLE_ENDOMETRIUM)|R175H(NCIH196_LUNG)|R175H(AU565_BREAST)|R175H(TYKNU_OVARY)|R175H(DETROIT562_UPPER_AERODIGESTIVE_TRACT)|R175H(SKUT1_SOFT_TISSUE)|R175H(CAL33_UPPER_AERODIGESTIVE_TRACT)|R175H(LS123_LARGE_INTESTINE)|R175H(SKBR3_BREAST)|R175H(RKN_OVARY)|R175H(HUCCT1_BILIARY_TRACT)	111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			26	21					0	0	0	0
TAOK1	57551	broad.mit.edu	37	17	27849481	27849481	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CV-7416-01A-11D-2078-08	TCGA-CV-7416-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	80c86be4-ccbe-4bf5-afcf-644cd337d37a	061150b2-1c4a-4126-9e7c-e9088d04db80	g.chr17:27849481C>T	uc002hdz.1	+	17	2286	c.2092C>T	c.(2092-2094)CGA>TGA	p.R698*	TAOK1_uc010wbe.1_Intron|TAOK1_uc010wbf.1_Nonsense_Mutation_p.R698*	NM_020791	NP_065842	Q7L7X3	TAOK1_HUMAN	TAO kinase 1	698					mitotic prometaphase	cytosol|intracellular membrane-bounded organelle	ATP binding|protein serine/threonine kinase activity			upper_aerodigestive_tract(1)|lung(1)|central_nervous_system(1)|skin(1)	4			Colorectal(6;0.198)			GCGAAGAGAACGAGAACTAAG	0.428		NA											12	48					0	0	0	0
KRT24	192666	broad.mit.edu	37	17	38855898	38855898	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7416-01A-11D-2078-08	TCGA-CV-7416-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	80c86be4-ccbe-4bf5-afcf-644cd337d37a	061150b2-1c4a-4126-9e7c-e9088d04db80	g.chr17:38855898C>T	uc002hvd.2	-	6	1216	c.1159G>A	c.(1159-1161)GGA>AGA	p.G387R		NM_019016	NP_061889	Q2M2I5	K1C24_HUMAN	keratin 24	387	Rod.|Coil 2.					cytoplasm|intermediate filament	structural molecule activity				0		Breast(137;0.00526)				GCCAGGGTTCCCTCCAGGGAG	0.423		NA											29	55					0	0	0	0
KIF19	124602	broad.mit.edu	37	17	72322500	72322500	+	Silent	SNP	C	C	T			TCGA-CV-7416-01A-11D-2078-08	TCGA-CV-7416-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	80c86be4-ccbe-4bf5-afcf-644cd337d37a	061150b2-1c4a-4126-9e7c-e9088d04db80	g.chr17:72322500C>T	uc002jkm.3	+	1	150	c.12C>T	c.(10-12)AGC>AGT	p.S4S	KIF19_uc002jkj.2_Silent_p.S4S|KIF19_uc002jkk.2_Silent_p.S4S|KIF19_uc002jkl.2_Silent_p.S4S	NM_153209	NP_694941	Q2TAC6	KIF19_HUMAN	kinesin family member 19	4					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity				0						TGAAGGACAGCGGGGACTCCA	0.672		NA											11	51					0	0	0	0
CCDC40	55036	broad.mit.edu	37	17	78073373	78073373	+	Silent	SNP	G	G	A			TCGA-CV-7416-01A-11D-2078-08	TCGA-CV-7416-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	80c86be4-ccbe-4bf5-afcf-644cd337d37a	061150b2-1c4a-4126-9e7c-e9088d04db80	g.chr17:78073373G>A	uc010dht.2	+	20	3255	c.3228G>A	c.(3226-3228)CAG>CAA	p.Q1076Q	CCDC40_uc002jxm.3_Silent_p.Q859Q|CCDC40_uc002jxn.3_Silent_p.Q472Q|GAA_uc002jxo.2_5'Flank|GAA_uc002jxp.2_5'Flank|GAA_uc002jxq.2_5'Flank	NM_017950	NP_060420	Q4G0X9	CCD40_HUMAN	coiled-coil domain containing 40	1076					axonemal dynein complex assembly|ciliary cell motility|cilium movement involved in determination of left/right asymmetry|flagellar cell motility	cilium|cytoplasm				ovary(3)	3	all_neural(118;0.167)		OV - Ovarian serous cystadenocarcinoma(97;0.0292)|BRCA - Breast invasive adenocarcinoma(99;0.149)			AGCACCTGCAGGCTGTGAAGG	0.572		NA											13	41					0	0	0	0
TMEM161A	54929	broad.mit.edu	37	19	19231608	19231608	+	Silent	SNP	G	G	A			TCGA-CV-7416-01A-11D-2078-08	TCGA-CV-7416-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	80c86be4-ccbe-4bf5-afcf-644cd337d37a	061150b2-1c4a-4126-9e7c-e9088d04db80	g.chr19:19231608G>A	uc002nlg.2	-	11	1182	c.1152C>T	c.(1150-1152)CTC>CTT	p.L384L	TMEM161A_uc010eca.2_RNA|TMEM161A_uc002nlh.2_Silent_p.L359L|TMEM161A_uc002nli.2_Silent_p.L281L|TMEM161A_uc002nlj.2_Silent_p.L259L	NM_017814	NP_060284	Q9NX61	T161A_HUMAN	transmembrane protein 161A precursor	384	Helical; (Potential).				cellular response to oxidative stress|cellular response to UV|negative regulation of apoptosis|positive regulation of DNA repair|response to retinoic acid	integral to membrane				breast(2)	2			OV - Ovarian serous cystadenocarcinoma(5;1.19e-05)|Epithelial(12;0.0011)			AGTTGAGGGTGAGGATGAGCG	0.612		NA											7	46					0	0	0	0
ZNF493	284443	broad.mit.edu	37	19	21607093	21607093	+	Silent	SNP	C	C	A			TCGA-CV-7416-01A-11D-2078-08	TCGA-CV-7416-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	80c86be4-ccbe-4bf5-afcf-644cd337d37a	061150b2-1c4a-4126-9e7c-e9088d04db80	g.chr19:21607093C>A	uc002npx.2	+	2	1528	c.1248C>A	c.(1246-1248)CCC>CCA	p.P416P	ZNF493_uc002npw.2_Silent_p.P544P|ZNF493_uc002npy.2_Silent_p.P416P	NM_175910	NP_787106	Q6ZR52	ZN493_HUMAN	zinc finger protein 493 isoform 1	416					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						GAGAAAAACCCTACAAATGTG	0.358		NA											4	11					0.00909568	0.00939147	1	0
RYR1	6261	broad.mit.edu	37	19	38948883	38948883	+	Silent	SNP	C	C	T			TCGA-CV-7416-01A-11D-2078-08	TCGA-CV-7416-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	80c86be4-ccbe-4bf5-afcf-644cd337d37a	061150b2-1c4a-4126-9e7c-e9088d04db80	g.chr19:38948883C>T	uc002oit.2	+	18	2248	c.2118C>T	c.(2116-2118)GTC>GTT	p.V706V	RYR1_uc002oiu.2_Silent_p.V706V	NM_000540	NP_000531	P21817	RYR1_HUMAN	skeletal muscle ryanodine receptor isoform 1	706	Cytoplasmic.|B30.2/SPRY 1.				muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(7)|pancreas(2)|breast(1)|central_nervous_system(1)|skin(1)	12	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	GCAACGGGGTCGGCGATGACC	0.657		NA											24	51					0	0	0	0
KPTN	11133	broad.mit.edu	37	19	47984035	47984035	+	Missense_Mutation	SNP	A	A	G			TCGA-CV-7416-01A-11D-2078-08	TCGA-CV-7416-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	80c86be4-ccbe-4bf5-afcf-644cd337d37a	061150b2-1c4a-4126-9e7c-e9088d04db80	g.chr19:47984035A>G	uc002pgy.2	-	6	685	c.581T>C	c.(580-582)CTG>CCG	p.L194P	KPTN_uc010xys.1_RNA	NM_007059	NP_008990	Q9Y664	KPTN_HUMAN	kaptin (actin binding protein)	194					actin filament organization|cellular component movement|sensory perception of sound	actin cytoskeleton|growth cone|microtubule organizing center|nucleus|perinuclear region of cytoplasm|stereocilium	actin binding			ovary(1)	1		all_cancers(25;1.55e-10)|all_epithelial(76;3.4e-08)|all_lung(116;1.73e-07)|Lung NSC(112;3.95e-07)|Ovarian(192;0.0139)|all_neural(266;0.026)|Breast(70;0.0503)		OV - Ovarian serous cystadenocarcinoma(262;0.000428)|all cancers(93;0.000631)|Epithelial(262;0.0153)|GBM - Glioblastoma multiforme(486;0.0694)		CAGGTTCGTCAGCTCTGGGAA	0.587		NA											25	101					0	0	0	0
DBP	1628	broad.mit.edu	37	19	49134221	49134221	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7416-01A-11D-2078-08	TCGA-CV-7416-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	80c86be4-ccbe-4bf5-afcf-644cd337d37a	061150b2-1c4a-4126-9e7c-e9088d04db80	g.chr19:49134221G>A	uc002pjx.3	-	4	1239	c.851C>T	c.(850-852)TCG>TTG	p.S284L	DBP_uc002pjy.2_3'UTR	NM_001352	NP_001343	Q10586	DBP_HUMAN	D site of albumin promoter (albumin D-box)	284					regulation of transcription from RNA polymerase II promoter|rhythmic process	nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0		all_lung(116;0.000125)|Lung NSC(112;0.000202)|all_epithelial(76;0.000283)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;9.98e-05)|all cancers(93;0.000112)|GBM - Glioblastoma multiforme(486;0.00615)|Epithelial(262;0.0155)		CGCCCGCACCGATATCTGGTT	0.647		NA											3	8					0	0	0	0
PPP2R1A	5518	broad.mit.edu	37	19	52722988	52722988	+	Silent	SNP	G	G	A			TCGA-CV-7416-01A-11D-2078-08	TCGA-CV-7416-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	80c86be4-ccbe-4bf5-afcf-644cd337d37a	061150b2-1c4a-4126-9e7c-e9088d04db80	g.chr19:52722988G>A	uc002pyp.2	+	10	1332	c.1173G>A	c.(1171-1173)GTG>GTA	p.V391V	PPP2R1A_uc010ydk.1_Silent_p.V336V|PPP2R1A_uc002pyq.2_Silent_p.V212V	NM_014225	NP_055040	P30153	2AAA_HUMAN	alpha isoform of regulatory subunit A, protein	391	PP2A subunit B binding.|HEAT 10.				ceramide metabolic process|chromosome segregation|G2/M transition of mitotic cell cycle|inactivation of MAPK activity|induction of apoptosis|negative regulation of cell growth|negative regulation of tyrosine phosphorylation of Stat3 protein|protein complex assembly|protein dephosphorylation|regulation of cell adhesion|regulation of cell differentiation|regulation of DNA replication|regulation of transcription, DNA-dependent|regulation of Wnt receptor signaling pathway|response to organic substance|RNA splicing|second-messenger-mediated signaling	chromosome, centromeric region|cytosol|membrane|microtubule cytoskeleton|mitochondrion|nucleus|protein phosphatase type 2A complex|soluble fraction	antigen binding|protein heterodimerization activity|protein phosphatase type 2A regulator activity			endometrium(31)|ovary(28)|lung(2)|breast(2)|skin(1)|kidney(1)|pancreas(1)	66				GBM - Glioblastoma multiforme(134;0.00456)|OV - Ovarian serous cystadenocarcinoma(262;0.015)		TGGACTGTGTGAACGAGGTGA	0.577		NA	Mis		clear cell ovarian carcinoma								11	22					0	0	0	0
ZNF667	63934	broad.mit.edu	37	19	56952582	56952582	+	Silent	SNP	C	C	A			TCGA-CV-7416-01A-11D-2078-08	TCGA-CV-7416-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	80c86be4-ccbe-4bf5-afcf-644cd337d37a	061150b2-1c4a-4126-9e7c-e9088d04db80	g.chr19:56952582C>A	uc002qnd.2	-	5	1944	c.1782G>T	c.(1780-1782)CGG>CGT	p.R594R	ZNF667_uc010etl.2_Silent_p.R376R|ZNF667_uc002qne.2_Silent_p.R594R|ZNF667_uc010etm.2_Silent_p.R537R	NM_022103	NP_071386	Q5HYK9	ZN667_HUMAN	zinc finger protein 667	594	C2H2-type 15.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			pancreas(1)	1		Colorectal(82;0.000256)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0615)		GGGATGAACTCCGACTATATG	0.388		NA											21	42					7.88e-14	8.77e-14	1	0
ZNF329	79673	broad.mit.edu	37	19	58639326	58639326	+	Silent	SNP	C	C	T			TCGA-CV-7416-01A-11D-2078-08	TCGA-CV-7416-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	80c86be4-ccbe-4bf5-afcf-644cd337d37a	061150b2-1c4a-4126-9e7c-e9088d04db80	g.chr19:58639326C>T	uc002qrn.2	-	4	1782	c.1545G>A	c.(1543-1545)CAG>CAA	p.Q515Q	ZNF329_uc010euk.1_RNA|ZNF329_uc002qro.1_RNA|ZNF329_uc002qrp.1_RNA	NM_024620	NP_078896	Q86UD4	ZN329_HUMAN	zinc finger protein 329	515	C2H2-type 12.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1		Colorectal(82;5.46e-05)|all_neural(62;0.0182)|Breast(46;0.029)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.017)|Lung(386;0.216)		TTTTTCCACACTGAGGACACC	0.512		NA											29	72					0	0	0	0
KHK	3795	broad.mit.edu	37	2	27317367	27317367	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7416-01A-11D-2078-08	TCGA-CV-7416-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	80c86be4-ccbe-4bf5-afcf-644cd337d37a	061150b2-1c4a-4126-9e7c-e9088d04db80	g.chr2:27317367C>T	uc002ril.2	+	3	749	c.232C>T	c.(232-234)CGC>TGC	p.R78C	KHK_uc002rim.2_Intron|KHK_uc002rin.2_Missense_Mutation_p.R79C|KHK_uc002rio.2_Intron	NM_000221	NP_000212	P50053	KHK_HUMAN	ketohexokinase isoform a	78					fructose catabolic process	cytosol	ATP binding|ketohexokinase activity|protein binding				0	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TGACCTCCGCCGCTATTCTGT	0.597		NA											20	51					0	0	0	0
FBXO11	80204	broad.mit.edu	37	2	48066041	48066041	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7416-01A-11D-2078-08	TCGA-CV-7416-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	80c86be4-ccbe-4bf5-afcf-644cd337d37a	061150b2-1c4a-4126-9e7c-e9088d04db80	g.chr2:48066041C>T	uc010fbl.2	-	4	406	c.292G>A	c.(292-294)GTA>ATA	p.V98I	FBXO11_uc002rwe.2_Missense_Mutation_p.V98I|FBXO11_uc002rwf.2_Missense_Mutation_p.V98I|FBXO11_uc002rwg.1_Missense_Mutation_p.V98I	NM_025133	NP_079409	Q86XK2	FBX11_HUMAN	F-box only protein 11 isoform 1	182	F-box.				ubiquitin-dependent protein catabolic process	cytoplasm|nucleolus|ubiquitin ligase complex	protein binding|protein-arginine N-methyltransferase activity|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|lung(1)	2		Acute lymphoblastic leukemia(82;0.0299)|all_hematologic(82;0.0358)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)			CGTTTACATACACAAGCTGCT	0.378		NA											3	40					0	0	0	0
POLR1A	25885	broad.mit.edu	37	2	86279995	86279995	+	Silent	SNP	G	G	A			TCGA-CV-7416-01A-11D-2078-08	TCGA-CV-7416-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	80c86be4-ccbe-4bf5-afcf-644cd337d37a	061150b2-1c4a-4126-9e7c-e9088d04db80	g.chr2:86279995G>A	uc002sqs.2	-	16	2716	c.2337C>T	c.(2335-2337)ACC>ACT	p.T779T	POLR1A_uc010ytb.1_Silent_p.T145T	NM_015425	NP_056240	O95602	RPA1_HUMAN	DNA-directed RNA polymerase I A	779					termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription initiation from RNA polymerase I promoter	DNA-directed RNA polymerase I complex|nucleoplasm	DNA binding|DNA-directed RNA polymerase activity|protein binding|zinc ion binding			ovary(2)|skin(1)	3						GGGCCAGGCAGGTTAGAACCT	0.642		NA											11	19					0	0	0	0
TBR1	10716	broad.mit.edu	37	2	162273105	162273105	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CV-7416-01A-11D-2078-08	TCGA-CV-7416-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	80c86be4-ccbe-4bf5-afcf-644cd337d37a	061150b2-1c4a-4126-9e7c-e9088d04db80	g.chr2:162273105C>T	uc002ubw.1	+	1	486	c.184C>T	c.(184-186)CAG>TAG	p.Q62*	TBR1_uc010foy.2_5'Flank	NM_006593	NP_006584	Q16650	TBR1_HUMAN	T-box, brain, 1	62						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|central_nervous_system(1)	2						GATGACGAATCAGTCAGATAC	0.493		NA											13	38					0	0	0	0
WIPF1	7456	broad.mit.edu	37	2	175431842	175431842	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7416-01A-11D-2078-08	TCGA-CV-7416-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	80c86be4-ccbe-4bf5-afcf-644cd337d37a	061150b2-1c4a-4126-9e7c-e9088d04db80	g.chr2:175431842G>A	uc002uiy.2	-	8	1744	c.1412C>T	c.(1411-1413)ACG>ATG	p.T471M	uc002uiw.2_Intron|uc002uix.1_Intron|WIPF1_uc002uja.2_Missense_Mutation_p.T471M|WIPF1_uc010fqt.1_Missense_Mutation_p.T471M|WIPF1_uc002uiz.2_Missense_Mutation_p.T471M|WIPF1_uc002ujb.1_Missense_Mutation_p.T471M	NM_003387	NP_003378	O43516	WIPF1_HUMAN	WAS/WASL interacting protein family, member 1	471					actin polymerization or depolymerization|protein complex assembly	cytoplasmic membrane-bounded vesicle	actin binding|profilin binding			ovary(1)|skin(1)	2						ACTTTTGGTCGTTTGTACATA	0.458		NA											14	33					0	0	0	0
C2orf67	151050	broad.mit.edu	37	2	211018847	211018847	+	Missense_Mutation	SNP	C	C	A			TCGA-CV-7416-01A-11D-2078-08	TCGA-CV-7416-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	80c86be4-ccbe-4bf5-afcf-644cd337d37a	061150b2-1c4a-4126-9e7c-e9088d04db80	g.chr2:211018847C>A	uc002vds.2	-	2	668	c.460G>T	c.(460-462)GAT>TAT	p.D154Y	C2orf67_uc002vdt.2_Missense_Mutation_p.D154Y|C2orf67_uc002vdw.2_Missense_Mutation_p.D154Y|C2orf67_uc002vdy.1_Missense_Mutation_p.D154Y|C2orf67_uc002vdv.2_Missense_Mutation_p.D154Y|C2orf67_uc002vdx.1_Missense_Mutation_p.D154Y	NM_152519	NP_689732	A0AUZ9	CB067_HUMAN	hypothetical protein LOC151050	154										ovary(3)	3		Renal(323;0.202)		Epithelial(149;0.00435)|Lung(261;0.0529)|LUSC - Lung squamous cell carcinoma(261;0.0551)|all cancers(144;0.0696)		ATATTTGAATCCAGAATAATT	0.348		NA											8	23					0.000274275	0.000293949	1	0
CXCR2	3579	broad.mit.edu	37	2	219000421	219000421	+	Silent	SNP	C	C	T	rs13306439		TCGA-CV-7416-01A-11D-2078-08	TCGA-CV-7416-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	80c86be4-ccbe-4bf5-afcf-644cd337d37a	061150b2-1c4a-4126-9e7c-e9088d04db80	g.chr2:219000421C>T	uc002vgz.1	+	4	1122	c.897C>T	c.(895-897)ACC>ACT	p.T299T	CXCR2_uc002vha.1_Silent_p.T299T|CXCR2_uc002vhb.1_Silent_p.T299T	NM_001557	NP_001548	P25025	CXCR2_HUMAN	interleukin 8 receptor beta	299	Helical; Name=7; (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|cellular defense response|dendritic cell chemotaxis|inflammatory response|neutrophil activation|neutrophil chemotaxis|positive regulation of cell proliferation	cell surface|integral to plasma membrane|mast cell granule	interleukin-8 receptor activity			lung(1)|breast(1)	2						TGGATGCCACCGAGATTCTGG	0.567		NA											9	60					0	0	0	0
WDFY1	57590	broad.mit.edu	37	2	224743419	224743419	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7416-01A-11D-2078-08	TCGA-CV-7416-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	80c86be4-ccbe-4bf5-afcf-644cd337d37a	061150b2-1c4a-4126-9e7c-e9088d04db80	g.chr2:224743419C>T	uc002vnq.2	-	12	1253	c.1202G>A	c.(1201-1203)TGC>TAC	p.C401Y		NM_020830	NP_065881	Q8IWB7	WDFY1_HUMAN	WD repeat and FYVE domain containing 1	401	WD 7.					cytosol|early endosome|nucleus	1-phosphatidylinositol binding|zinc ion binding			lung(1)	1		all_lung(227;0.00682)|Lung NSC(271;0.00859)|Renal(207;0.0112)|all_hematologic(139;0.189)		Epithelial(121;5.34e-10)|all cancers(144;1.67e-07)|Lung(261;0.00807)|LUSC - Lung squamous cell carcinoma(224;0.00843)		CGCCAGACTGCAGCCCACCAC	0.542		NA											4	15					0	0	0	0
COL4A4	1286	broad.mit.edu	37	2	227945173	227945173	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7416-01A-11D-2078-08	TCGA-CV-7416-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	80c86be4-ccbe-4bf5-afcf-644cd337d37a	061150b2-1c4a-4126-9e7c-e9088d04db80	g.chr2:227945173C>G	uc010zlt.1	-	24	2443	c.1789G>C	c.(1789-1791)GAT>CAT	p.D597H		NM_000092	NP_000083	P53420	CO4A4_HUMAN	alpha 4 type IV collagen precursor	597	Triple-helical region.				axon guidance|glomerular basement membrane development	basal lamina|collagen type IV	extracellular matrix structural constituent|protein binding			ovary(5)|central_nervous_system(3)|pancreas(1)|breast(1)|skin(1)	11		Renal(207;0.00844)|all_lung(227;0.0187)|Lung NSC(271;0.0879)|all_hematologic(139;0.21)|Esophageal squamous(248;0.242)		Epithelial(121;6.7e-11)|all cancers(144;5.39e-08)|Lung(261;0.0132)|LUSC - Lung squamous cell carcinoma(224;0.0181)		GGTCCTGGATCCCCTTTTTCT	0.463		NA											15	54					0	0	0	0
COL18A1	80781	broad.mit.edu	37	21	46899995	46899995	+	Silent	SNP	G	G	A			TCGA-CV-7416-01A-11D-2078-08	TCGA-CV-7416-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	80c86be4-ccbe-4bf5-afcf-644cd337d37a	061150b2-1c4a-4126-9e7c-e9088d04db80	g.chr21:46899995G>A	uc011afs.1	+	10	2589	c.2568G>A	c.(2566-2568)GGG>GGA	p.G856G	COL18A1_uc002zhg.2_Silent_p.G441G|COL18A1_uc002zhi.2_Silent_p.G621G	NM_130444	NP_569711	P39060	COIA1_HUMAN	alpha 1 type XVIII collagen isoform 3 precursor	856	Triple-helical region 2 (COL2).				cell adhesion|negative regulation of cell proliferation|organ morphogenesis|visual perception	collagen|extracellular space	extracellular matrix structural constituent|metal ion binding|protein binding			central_nervous_system(1)	1				Colorectal(79;0.0157)|READ - Rectum adenocarcinoma(84;0.0929)		GAGACCCTGGGGTTGGAGAGA	0.502		NA											3	47					0	0	0	0
CECR1	51816	broad.mit.edu	37	22	17670900	17670900	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7416-01A-11D-2078-08	TCGA-CV-7416-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	80c86be4-ccbe-4bf5-afcf-644cd337d37a	061150b2-1c4a-4126-9e7c-e9088d04db80	g.chr22:17670900C>T	uc002zmk.1	-	5	1116	c.904G>A	c.(904-906)GCA>ACA	p.A302T	CECR1_uc010gqu.1_Missense_Mutation_p.A302T|CECR1_uc011agi.1_Missense_Mutation_p.A260T|CECR1_uc011agj.1_3'UTR|CECR1_uc002zmj.1_Missense_Mutation_p.A61T	NM_017424	NP_059120	Q9NZK5	CECR1_HUMAN	cat eye syndrome critical region protein 1	302					adenosine catabolic process|hypoxanthine salvage|inosine biosynthetic process|multicellular organismal development|purine ribonucleoside monophosphate biosynthetic process	extracellular space|Golgi apparatus	adenosine deaminase activity|adenosine receptor binding|growth factor activity|heparin binding|protein homodimerization activity|proteoglycan binding|zinc ion binding			ovary(1)	1		all_epithelial(15;0.0152)|Lung NSC(13;0.0875)|all_lung(157;0.106)				ATGGATTCTGCGATGACAGCC	0.577		NA											10	37					0	0	0	0
GNB1L	54584	broad.mit.edu	37	22	19789706	19789706	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7416-01A-11D-2078-08	TCGA-CV-7416-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	80c86be4-ccbe-4bf5-afcf-644cd337d37a	061150b2-1c4a-4126-9e7c-e9088d04db80	g.chr22:19789706C>T	uc002zqe.1	-	6	944	c.550G>A	c.(550-552)GGC>AGC	p.G184S	GNB1L_uc002zqd.1_Missense_Mutation_p.G40S|GNB1L_uc002zqf.1_Missense_Mutation_p.G184S	NM_053004	NP_443730	Q9BYB4	GNB1L_HUMAN	guanine nucleotide binding protein	184	WD 3.				G-protein coupled receptor protein signaling pathway|intracellular signal transduction	internal side of plasma membrane|intracellular				breast(1)	1	Colorectal(54;0.0993)					TCCTCATAGCCGGCCAGAAGG	0.622		NA											12	31					0	0	0	0
DCLK3	85443	broad.mit.edu	37	3	36779850	36779850	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7416-01A-11D-2078-08	TCGA-CV-7416-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	80c86be4-ccbe-4bf5-afcf-644cd337d37a	061150b2-1c4a-4126-9e7c-e9088d04db80	g.chr3:36779850C>T	uc003cgi.2	-	2	792	c.301G>A	c.(301-303)GAG>AAG	p.E101K		NM_033403	NP_208382	Q9C098	DCLK3_HUMAN	doublecortin-like kinase 3	101						cytoplasm|nucleus	ATP binding|protein serine/threonine kinase activity			lung(3)|large_intestine(2)|breast(1)|skin(1)|ovary(1)|kidney(1)	9						GGTTCTGGCTCCCATTTCCCC	0.592		NA											46	85					0	0	0	0
DCLK3	85443	broad.mit.edu	37	3	36779895	36779895	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7416-01A-11D-2078-08	TCGA-CV-7416-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	80c86be4-ccbe-4bf5-afcf-644cd337d37a	061150b2-1c4a-4126-9e7c-e9088d04db80	g.chr3:36779895C>G	uc003cgi.2	-	2	747	c.256G>C	c.(256-258)GAT>CAT	p.D86H		NM_033403	NP_208382	Q9C098	DCLK3_HUMAN	doublecortin-like kinase 3	86						cytoplasm|nucleus	ATP binding|protein serine/threonine kinase activity			lung(3)|large_intestine(2)|breast(1)|skin(1)|ovary(1)|kidney(1)	9						GCTCTGTCATCTAGTGAAAGC	0.622		NA											51	100					0	0	0	0
PLCD1	5333	broad.mit.edu	37	3	38050888	38050888	+	Missense_Mutation	SNP	T	T	C			TCGA-CV-7416-01A-11D-2078-08	TCGA-CV-7416-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	80c86be4-ccbe-4bf5-afcf-644cd337d37a	061150b2-1c4a-4126-9e7c-e9088d04db80	g.chr3:38050888T>C	uc003chn.2	-	10	1605	c.1481A>G	c.(1480-1482)GAC>GGC	p.D494G	PLCD1_uc003chm.2_Missense_Mutation_p.D515G	NM_006225	NP_006216	P51178	PLCD1_HUMAN	phospholipase C, delta 1 isoform 2	494	PI-PLC Y-box.				intracellular signal transduction|lipid catabolic process|phospholipid metabolic process	cytoplasm	calcium ion binding|GTPase activating protein binding|phosphatidylinositol phospholipase C activity|signal transducer activity			skin(1)	1				KIRC - Kidney renal clear cell carcinoma(284;0.0519)|Kidney(284;0.0653)		AATGACCATGTCAGAGAGCTC	0.577		NA											17	14					0	0	0	0
CACNA2D2	9254	broad.mit.edu	37	3	50402370	50402370	+	Silent	SNP	C	C	T			TCGA-CV-7416-01A-11D-2078-08	TCGA-CV-7416-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	80c86be4-ccbe-4bf5-afcf-644cd337d37a	061150b2-1c4a-4126-9e7c-e9088d04db80	g.chr3:50402370C>T	uc003daq.2	-	38	3299	c.3261G>A	c.(3259-3261)CAG>CAA	p.Q1087Q	CACNA2D2_uc003dap.2_Silent_p.Q1080Q|CACNA2D2_uc003dao.2_Silent_p.Q160Q	NM_006030	NP_006021	Q9NY47	CA2D2_HUMAN	calcium channel, voltage-dependent, alpha	1087	Extracellular (Potential).				energy reserve metabolic process|regulation of insulin secretion	integral to membrane|plasma membrane	calcium channel activity|metal ion binding|voltage-gated ion channel activity			lung(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.000365)|KIRC - Kidney renal clear cell carcinoma(197;0.00862)|Kidney(197;0.01)	Gabapentin(DB00996)	ATCGCGGTCTCTGCACTAGCT	0.453		NA											8	30					0	0	0	0
MYH15	22989	broad.mit.edu	37	3	108117636	108117636	+	Nonsense_Mutation	SNP	C	C	A			TCGA-CV-7416-01A-11D-2078-08	TCGA-CV-7416-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	80c86be4-ccbe-4bf5-afcf-644cd337d37a	061150b2-1c4a-4126-9e7c-e9088d04db80	g.chr3:108117636C>A	uc003dxa.1	-	36	5098	c.5041G>T	c.(5041-5043)GAG>TAG	p.E1681*		NM_014981	NP_055796	Q9Y2K3	MYH15_HUMAN	myosin, heavy polypeptide 15	1681	Potential.					myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			ovary(5)|central_nervous_system(2)	7						GCCACCTGCTCCTTCAGATCA	0.537		NA											9	163					0.000673444	0.00071571	1	0
SEMA5B	54437	broad.mit.edu	37	3	122647874	122647874	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7416-01A-11D-2078-08	TCGA-CV-7416-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	80c86be4-ccbe-4bf5-afcf-644cd337d37a	061150b2-1c4a-4126-9e7c-e9088d04db80	g.chr3:122647874C>T	uc003efz.1	-	6	810	c.506G>A	c.(505-507)CGC>CAC	p.R169H	SEMA5B_uc011bju.1_Missense_Mutation_p.R111H|SEMA5B_uc003ega.1_RNA|SEMA5B_uc003egb.1_Missense_Mutation_p.R169H|SEMA5B_uc010hro.1_Missense_Mutation_p.R111H|SEMA5B_uc010hrp.1_RNA	NM_001031702	NP_001026872	Q9P283	SEM5B_HUMAN	semaphorin 5B isoform 1	169	Extracellular (Potential).|Sema.				cell differentiation|nervous system development	integral to membrane	receptor activity			ovary(2)|breast(2)|pancreas(2)|central_nervous_system(1)	7				GBM - Glioblastoma multiforme(114;0.0367)		GCAGGAGCGGCGCGTGTCCTC	0.617		NA											8	30					0	0	0	0
MTTP	4547	broad.mit.edu	37	4	100543978	100543978	+	Silent	SNP	G	G	A			TCGA-CV-7416-01A-11D-2078-08	TCGA-CV-7416-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	80c86be4-ccbe-4bf5-afcf-644cd337d37a	061150b2-1c4a-4126-9e7c-e9088d04db80	g.chr4:100543978G>A	uc003hvc.3	+	19	2914	c.2658G>A	c.(2656-2658)CCG>CCA	p.P886P	MTTP_uc011cej.1_Silent_p.P913P	NM_000253	NP_000244	P55157	MTP_HUMAN	microsomal triglyceride transfer protein large	886					lipid metabolic process|lipoprotein metabolic process	endoplasmic reticulum lumen	lipid binding|lipid transporter activity			ovary(3)|central_nervous_system(1)	4				OV - Ovarian serous cystadenocarcinoma(123;6.04e-09)	Hesperetin(DB01094)	CCCCTCAGCCGGATAGTACTT	0.443		NA											24	55					0	0	0	0
NKD2	85409	broad.mit.edu	37	5	1032273	1032273	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7416-01A-11D-2078-08	TCGA-CV-7416-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	80c86be4-ccbe-4bf5-afcf-644cd337d37a	061150b2-1c4a-4126-9e7c-e9088d04db80	g.chr5:1032273C>T	uc003jbt.1	+	4	153	c.148C>T	c.(148-150)CCC>TCC	p.P50S	NKD2_uc010itf.1_Missense_Mutation_p.P50S	NM_033120	NP_149111	Q969F2	NKD2_HUMAN	naked cuticle homolog 2	50	Targeting to the basolateral cell membrane.				exocytosis|Wnt receptor signaling pathway	cytoplasmic membrane-bounded vesicle|plasma membrane	calcium ion binding|ubiquitin protein ligase binding				0	Lung NSC(6;2.47e-13)|all_lung(6;1.67e-12)|all_epithelial(6;3.28e-09)		Epithelial(17;0.00093)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|all cancers(22;0.00417)|Lung(60;0.165)			GCAGGAGCTGCCCAATGGGGA	0.662		NA											22	204					0	0	0	0
RXFP3	51289	broad.mit.edu	37	5	33937016	33937016	+	Silent	SNP	G	G	A			TCGA-CV-7416-01A-11D-2078-08	TCGA-CV-7416-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	80c86be4-ccbe-4bf5-afcf-644cd337d37a	061150b2-1c4a-4126-9e7c-e9088d04db80	g.chr5:33937016G>A	uc003jic.1	+	1	528	c.171G>A	c.(169-171)CCG>CCA	p.P57P		NM_016568	NP_057652	Q9NSD7	RL3R1_HUMAN	relaxin/insulin-like family peptide receptor 3	57	Extracellular (Potential).					integral to plasma membrane	N-formyl peptide receptor activity			upper_aerodigestive_tract(1)	1						TGGAGTTGCCGGACGGCGCGC	0.687		NA											14	153					0	0	0	0
MARVELD2	153562	broad.mit.edu	37	5	68716051	68716051	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7416-01A-11D-2078-08	TCGA-CV-7416-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	80c86be4-ccbe-4bf5-afcf-644cd337d37a	061150b2-1c4a-4126-9e7c-e9088d04db80	g.chr5:68716051G>A	uc003jwq.2	+	2	898	c.839G>A	c.(838-840)CGG>CAG	p.R280Q	MARVELD2_uc010ixf.2_Missense_Mutation_p.R280Q|MARVELD2_uc003jwr.1_Missense_Mutation_p.R280Q|MARVELD2_uc003jws.1_Intron	NM_001038603	NP_001033692	Q8N4S9	MALD2_HUMAN	MARVEL domain containing 2 isoform 1	280	MARVEL.|Extracellular (Potential).				sensory perception of sound	integral to membrane|tight junction					0		Lung NSC(167;0.000937)|Prostate(74;0.0187)|Ovarian(174;0.16)		OV - Ovarian serous cystadenocarcinoma(47;7.31e-57)|Epithelial(20;1.05e-52)|all cancers(19;2.63e-48)|Lung(70;0.0183)		ATGTATTACCGGACCATTCTT	0.433		NA											15	55					0	0	0	0
PCDHA4	56144	broad.mit.edu	37	5	140187182	140187182	+	Missense_Mutation	SNP	A	A	C	rs144914662	byFrequency	TCGA-CV-7416-01A-11D-2078-08	TCGA-CV-7416-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	80c86be4-ccbe-4bf5-afcf-644cd337d37a	061150b2-1c4a-4126-9e7c-e9088d04db80	g.chr5:140187182A>C	uc003lhi.2	+	1	511	c.410A>C	c.(409-411)CAA>CCA	p.Q137P	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhh.1_Missense_Mutation_p.Q137P|PCDHA4_uc011daa.1_Missense_Mutation_p.Q137P	NM_018907	NP_061730	Q9UN74	PCDA4_HUMAN	protocadherin alpha 4 isoform 1 precursor	137	Extracellular (Potential).|Cadherin 2.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			ovary(4)|skin(2)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCAGCAACACAAAAGAACCTG	0.572		NA											4	82					0	0	0	0
ZFAND3	60685	broad.mit.edu	37	6	38084407	38084407	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7416-01A-11D-2078-08	TCGA-CV-7416-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	80c86be4-ccbe-4bf5-afcf-644cd337d37a	061150b2-1c4a-4126-9e7c-e9088d04db80	g.chr6:38084407G>C	uc003onx.2	+	5	836	c.421G>C	c.(421-423)GAA>CAA	p.E141Q		NM_021943	NP_068762	Q9H8U3	ZFAN3_HUMAN	zinc finger, AN1-type domain 3	141							DNA binding|zinc ion binding			ovary(1)	1						TGAGAATACGGAACGGTCCGA	0.498		NA											14	33					0	0	0	0
SLC22A7	10864	broad.mit.edu	37	6	43267656	43267656	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7416-01A-11D-2078-08	TCGA-CV-7416-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	80c86be4-ccbe-4bf5-afcf-644cd337d37a	061150b2-1c4a-4126-9e7c-e9088d04db80	g.chr6:43267656G>C	uc003out.2	+	5	778	c.679G>C	c.(679-681)GAG>CAG	p.E227Q	SLC22A7_uc010jyl.1_Missense_Mutation_p.E228Q|SLC22A7_uc003ous.2_Missense_Mutation_p.E225Q	NM_153320	NP_696961	Q9Y694	S22A7_HUMAN	solute carrier family 22 member 7 isoform b	227						basolateral plasma membrane|integral to plasma membrane|membrane fraction	anion:anion antiporter activity|sodium-independent organic anion transmembrane transporter activity				0			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.00998)|OV - Ovarian serous cystadenocarcinoma(102;0.0305)			GCTGGATGTGGAGCACCGCAC	0.607		NA											17	42					0	0	0	0
HNRNPA2B1	3181	broad.mit.edu	37	7	26233291	26233291	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7416-01A-11D-2078-08	TCGA-CV-7416-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	80c86be4-ccbe-4bf5-afcf-644cd337d37a	061150b2-1c4a-4126-9e7c-e9088d04db80	g.chr7:26233291C>T	uc003sxr.3	-	9	997	c.781G>A	c.(781-783)GGT>AGT	p.G261S	HNRNPA2B1_uc003sxs.3_Missense_Mutation_p.G249S	NM_031243	NP_112533	P22626	ROA2_HUMAN	heterogeneous nuclear ribonucleoprotein A2/B1	261	Gly-rich.				RNA transport	catalytic step 2 spliceosome|cytoplasm|heterogeneous nuclear ribonucleoprotein complex|nucleolus|nucleoplasm	nucleotide binding|protein binding|protein binding|RNA binding|single-stranded telomeric DNA binding			ovary(1)|central_nervous_system(1)|skin(1)	3						CCTCCATAACCGGGGCTACCT	0.448		NA	T	ETV1	prostate								20	55					0	0	0	0
AUTS2	26053	broad.mit.edu	37	7	70254942	70254942	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7416-01A-11D-2078-08	TCGA-CV-7416-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	80c86be4-ccbe-4bf5-afcf-644cd337d37a	061150b2-1c4a-4126-9e7c-e9088d04db80	g.chr7:70254942G>A	uc003tvw.3	+	19	3483	c.2740G>A	c.(2740-2742)GGC>AGC	p.G914S	AUTS2_uc003tvx.3_Missense_Mutation_p.G890S|AUTS2_uc011keg.1_Missense_Mutation_p.G366S	NM_015570	NP_056385	Q8WXX7	AUTS2_HUMAN	autism susceptibility candidate 2 isoform 1	914										ovary(2)|central_nervous_system(1)	3		all_cancers(73;0.0264)|all_epithelial(88;0.0198)|Lung NSC(55;0.0599)|all_lung(88;0.093)		LUSC - Lung squamous cell carcinoma(90;0.082)|Lung(90;0.186)		GGCGAAAGAGGGCCACCTGCC	0.687		NA											3	15					0	0	0	0
FLNC	2318	broad.mit.edu	37	7	128497288	128497288	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7416-01A-11D-2078-08	TCGA-CV-7416-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	80c86be4-ccbe-4bf5-afcf-644cd337d37a	061150b2-1c4a-4126-9e7c-e9088d04db80	g.chr7:128497288G>A	uc003vnz.3	+	46	7887	c.7678G>A	c.(7678-7680)GTG>ATG	p.V2560M	FLNC_uc003voa.3_Missense_Mutation_p.V2527M	NM_001458	NP_001449	Q14315	FLNC_HUMAN	gamma filamin isoform a	2560	Interaction with INPPL1.|Filamin 23.				cell junction assembly	cytoskeleton|cytosol|plasma membrane|sarcomere	actin binding			breast(5)|large_intestine(3)|ovary(2)|central_nervous_system(1)|skin(1)	12						TGAGGGCCATGTGGTCACTTA	0.607		NA											16	71					0	0	0	0
SSPO	23145	broad.mit.edu	37	7	149509044	149509044	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7416-01A-11D-2078-08	TCGA-CV-7416-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	80c86be4-ccbe-4bf5-afcf-644cd337d37a	061150b2-1c4a-4126-9e7c-e9088d04db80	g.chr7:149509044C>G	uc010lpk.2	+	69	9590	c.9590C>G	c.(9589-9591)GCC>GGC	p.A3197G		NM_198455	NP_940857	A2VEC9	SSPO_HUMAN	SCO-spondin precursor	3197	TSP type-1 11.				cell adhesion	extracellular space	peptidase inhibitor activity				0	Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			CAGTGTTCAGCCTCCTGTGGC	0.697		NA											3	53					0	0	0	0
MLL3	58508	broad.mit.edu	37	7	151879181	151879181	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7416-01A-11D-2078-08	TCGA-CV-7416-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	80c86be4-ccbe-4bf5-afcf-644cd337d37a	061150b2-1c4a-4126-9e7c-e9088d04db80	g.chr7:151879181G>C	uc003wla.2	-	36	5983	c.5764C>G	c.(5764-5766)CCA>GCA	p.P1922A	MLL3_uc003wkz.2_Missense_Mutation_p.P983A	NM_170606	NP_733751	Q8NEZ4	MLL3_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 3	1922	Pro-rich.				intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			large_intestine(27)|pancreas(13)|ovary(9)|central_nervous_system(8)|breast(3)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	63	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)		TTTTCCACTGGTGCAGCAGAA	0.463		NA	N		medulloblastoma								17	56					0	0	0	0
PKHD1L1	93035	broad.mit.edu	37	8	110441662	110441662	+	Silent	SNP	C	C	T			TCGA-CV-7416-01A-11D-2078-08	TCGA-CV-7416-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	80c86be4-ccbe-4bf5-afcf-644cd337d37a	061150b2-1c4a-4126-9e7c-e9088d04db80	g.chr8:110441662C>T	uc003yne.2	+	26	3198	c.3094C>T	c.(3094-3096)CTA>TTA	p.L1032L		NM_177531	NP_803875	Q86WI1	PKHL1_HUMAN	fibrocystin L precursor	1032	Extracellular (Potential).				immune response	cytosol|extracellular space|integral to membrane	receptor activity			ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			ACTTGGAGACCTACTTCGTAC	0.323		NA								HNSCC(38;0.096)			4	8					0	0	0	0
GTF3C4	9329	broad.mit.edu	37	9	135553693	135553693	+	Silent	SNP	G	G	A	rs138509726	byFrequency	TCGA-CV-7416-01A-11D-2078-08	TCGA-CV-7416-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	80c86be4-ccbe-4bf5-afcf-644cd337d37a	061150b2-1c4a-4126-9e7c-e9088d04db80	g.chr9:135553693G>A	uc010mzv.2	+	2	945	c.687G>A	c.(685-687)CCG>CCA	p.P229P	GTF3C4_uc010mzw.2_RNA	NM_012204	NP_036336	Q9UKN8	TF3C4_HUMAN	general transcription factor IIIC 4	229					transcription initiation from RNA polymerase III promoter	transcription factor TFIIIC complex	DNA binding|enzyme activator activity|histone acetyltransferase activity|protein binding			ovary(1)|central_nervous_system(1)	2				OV - Ovarian serous cystadenocarcinoma(145;8.15e-07)|Epithelial(140;2.6e-05)		ATGAGGCCCCGGAAGGAAATC	0.517		NA											37	29					0	0	0	0
POLA1	5422	broad.mit.edu	37	X	24745918	24745918	+	Silent	SNP	C	C	G			TCGA-CV-7416-01A-11D-2078-08	TCGA-CV-7416-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	80c86be4-ccbe-4bf5-afcf-644cd337d37a	061150b2-1c4a-4126-9e7c-e9088d04db80	g.chrX:24745918C>G	uc004dbl.2	+	15	1556	c.1533C>G	c.(1531-1533)GTC>GTG	p.V511V	POLA1_uc004dbm.2_Silent_p.V517V|POLA1_uc004dbn.2_Silent_p.V375V	NM_016937	NP_058633	P09884	DPOLA_HUMAN	DNA-directed DNA polymerase alpha 1	511					cell proliferation|DNA replication checkpoint|DNA replication, synthesis of RNA primer|DNA-dependent DNA replication initiation|double-strand break repair via nonhomologous end joining|interspecies interaction between organisms|lagging strand elongation|leading strand elongation|M/G1 transition of mitotic cell cycle|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication	alpha DNA polymerase:primase complex|cytoplasm|nuclear envelope|nuclear matrix|nucleolus|nucleoplasm	chromatin binding|DNA-directed DNA polymerase activity|metal ion binding|nucleoside binding			ovary(2)|skin(1)	3					Clofarabine(DB00631)|Fludarabine(DB01073)	ATCAGCCAGTCAGTTGGTGTA	0.388		NA											8	46					0	0	0	0
FAM155B	27112	broad.mit.edu	37	X	68749788	68749788	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7416-01A-11D-2078-08	TCGA-CV-7416-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	80c86be4-ccbe-4bf5-afcf-644cd337d37a	061150b2-1c4a-4126-9e7c-e9088d04db80	g.chrX:68749788C>T	uc004dxk.2	+	3	1456	c.1408C>T	c.(1408-1410)CGG>TGG	p.R470W		NM_015686	NP_056501	O75949	F155B_HUMAN	transmembrane protein 28	471						integral to membrane				ovary(1)|breast(1)	2						GGGCCTGACACGGGAAGAGTG	0.632		NA											3	21					0	0	0	0
BRWD3	254065	broad.mit.edu	37	X	79960224	79960224	+	Nonsense_Mutation	SNP	T	T	A			TCGA-CV-7416-01A-11D-2078-08	TCGA-CV-7416-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	80c86be4-ccbe-4bf5-afcf-644cd337d37a	061150b2-1c4a-4126-9e7c-e9088d04db80	g.chrX:79960224T>A	uc004edt.2	-	23	2937	c.2674A>T	c.(2674-2676)AAG>TAG	p.K892*	BRWD3_uc010nmi.1_RNA|BRWD3_uc004edo.2_Nonsense_Mutation_p.K488*|BRWD3_uc004edp.2_Nonsense_Mutation_p.K721*|BRWD3_uc004edq.2_Nonsense_Mutation_p.K488*|BRWD3_uc010nmj.1_Nonsense_Mutation_p.K488*|BRWD3_uc004edr.2_Nonsense_Mutation_p.K562*|BRWD3_uc004eds.2_Nonsense_Mutation_p.K488*|BRWD3_uc004edu.2_Nonsense_Mutation_p.K562*|BRWD3_uc004edv.2_Nonsense_Mutation_p.K488*|BRWD3_uc004edw.2_Nonsense_Mutation_p.K488*|BRWD3_uc004edx.2_Nonsense_Mutation_p.K488*|BRWD3_uc004edy.2_Nonsense_Mutation_p.K488*|BRWD3_uc004edz.2_Nonsense_Mutation_p.K562*|BRWD3_uc004eea.2_Nonsense_Mutation_p.K562*|BRWD3_uc004eeb.2_Nonsense_Mutation_p.K488*	NM_153252	NP_694984	Q6RI45	BRWD3_HUMAN	bromodomain and WD repeat domain containing 3	892										ovary(4)	4						TCTAGGGACTTCAAATTTTCC	0.348		NA											16	444					0	0	0	0
BRWD3	254065	broad.mit.edu	37	X	80001189	80001189	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7416-01A-11D-2078-08	TCGA-CV-7416-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	80c86be4-ccbe-4bf5-afcf-644cd337d37a	061150b2-1c4a-4126-9e7c-e9088d04db80	g.chrX:80001189C>T	uc004edt.2	-	7	733	c.470G>A	c.(469-471)CGC>CAC	p.R157H	BRWD3_uc004edo.2_5'UTR|BRWD3_uc004edp.2_5'UTR|BRWD3_uc004edq.2_5'UTR|BRWD3_uc010nmj.1_Intron|BRWD3_uc004edr.2_5'UTR|BRWD3_uc004eds.2_5'UTR|BRWD3_uc004edu.2_5'UTR|BRWD3_uc004edv.2_5'UTR|BRWD3_uc004edw.2_5'UTR|BRWD3_uc004edx.2_5'UTR|BRWD3_uc004edy.2_5'UTR|BRWD3_uc004edz.2_5'UTR|BRWD3_uc004eea.2_5'UTR|BRWD3_uc004eeb.2_Intron	NM_153252	NP_694984	Q6RI45	BRWD3_HUMAN	bromodomain and WD repeat domain containing 3	157										ovary(4)	4						ATGACCAAAGCGACTACAGCC	0.373		NA											184	15					0	0	0	0
POU3F4	5456	broad.mit.edu	37	X	82763808	82763808	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7416-01A-11D-2078-08	TCGA-CV-7416-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	80c86be4-ccbe-4bf5-afcf-644cd337d37a	061150b2-1c4a-4126-9e7c-e9088d04db80	g.chrX:82763808C>T	uc004eeg.2	+	1	540	c.476C>T	c.(475-477)GCA>GTA	p.A159V		NM_000307	NP_000298	P49335	PO3F4_HUMAN	POU domain, class 3, transcription factor 4	159					sensory perception of sound	nucleus	sequence-specific DNA binding transcription factor activity			ovary(1)	1						GCCGCCTCTGCACAGAGCCTG	0.657		NA											6	63					0	0	0	0
TEX13A	56157	broad.mit.edu	37	X	104463741	104463741	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7416-01A-11D-2078-08	TCGA-CV-7416-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	80c86be4-ccbe-4bf5-afcf-644cd337d37a	061150b2-1c4a-4126-9e7c-e9088d04db80	g.chrX:104463741C>T	uc004ema.2	-	5	1247	c.1135G>A	c.(1135-1137)GAC>AAC	p.D379N	IL1RAPL2_uc004elz.1_Intron|TEX13A_uc004emb.2_3'UTR	NM_031274	NP_112564	Q9BXU3	TX13A_HUMAN	testis expressed sequence 13A	379	RanBP2-type.					intracellular	zinc ion binding			ovary(2)	2						CAGTCCCAGTCCCCTGGCCTG	0.532		NA											11	83					0	0	0	0
MAGEC1	9947	broad.mit.edu	37	X	140995293	140995293	+	Silent	SNP	A	A	T	rs147024850		TCGA-CV-7416-01A-11D-2078-08	TCGA-CV-7416-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	80c86be4-ccbe-4bf5-afcf-644cd337d37a	061150b2-1c4a-4126-9e7c-e9088d04db80	g.chrX:140995293A>T	uc004fbt.2	+	4	2389	c.2103A>T	c.(2101-2103)GGA>GGT	p.G701G	MAGEC1_uc010nsl.1_Intron	NM_005462	NP_005453	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	701							protein binding			ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	4	Acute lymphoblastic leukemia(192;6.56e-05)					CTCTTGAGGGAGAGGACTCCC	0.567		NA								HNSCC(15;0.026)			19	43					0	0	0	0
CACNA2D4	93589	broad.mit.edu	37	12	1995395	1995405	+	Frame_Shift_Del	DEL	GATATTAATGA	GATATTAATGA	-	rs10735005	by1000genomes	TCGA-CV-7416-01A-11D-2078-08	TCGA-CV-7416-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	80c86be4-ccbe-4bf5-afcf-644cd337d37a	061150b2-1c4a-4126-9e7c-e9088d04db80	g.chr12:1995395_1995405delGATATTAATGA	uc001qjp.2	-	8	1208_1218	c.977_987delTCATTAATATC	c.(976-987)TTCATTAATATCfs	p.F326fs	CACNA2D4_uc009zds.1_RNA|CACNA2D4_uc009zdt.1_Intron	NM_172364	NP_758952	Q7Z3S7	CA2D4_HUMAN	voltage-gated calcium channel alpha(2)delta-4	326_329	VWFA.|Extracellular (Potential).					integral to membrane	calcium channel activity|metal ion binding|voltage-gated ion channel activity			ovary(1)	1	Ovarian(42;0.107)	Myeloproliferative disorder(1001;0.206)	OV - Ovarian serous cystadenocarcinoma(31;0.00113)	Kidney(2;0.0205)|KIRC - Kidney renal clear cell carcinoma(2;0.0451)		TTACCGCTATGATATTAATGAAGTCATTCTC	0.498		NA											8	38	---	---	---	---	NA	NA	NA	NA
TRMT5	57570	broad.mit.edu	37	14	61442681	61442696	+	Frame_Shift_Del	DEL	TTCTTTGCTACTGGAA	TTCTTTGCTACTGGAA	-			TCGA-CV-7416-01A-11D-2078-08	TCGA-CV-7416-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	80c86be4-ccbe-4bf5-afcf-644cd337d37a	061150b2-1c4a-4126-9e7c-e9088d04db80	g.chr14:61442681_61442696delTTCTTTGCTACTGGAA	uc001xff.3	-	4	1032_1047	c.941_956delTTCCAGTAGCAAAGAA	c.(940-957)ATTCCAGTAGCAAAGAAAfs	p.I314fs		NM_020810	NP_065861	Q32P41	TRMT5_HUMAN	tRNA methyltransferase 5	314_319						cytoplasm	tRNA (guanine-N1-)-methyltransferase activity			central_nervous_system(2)|large_intestine(1)	3				OV - Ovarian serous cystadenocarcinoma(108;0.0873)		AGTGCAGTTTTTCTTTGCTACTGGAATGGCAAAGGG	0.417		NA											7	117	---	---	---	---	NA	NA	NA	NA
OR1D2	4991	broad.mit.edu	37	17	2995956	2995966	+	Frame_Shift_Del	DEL	TTGTCCAGGGC	TTGTCCAGGGC	-	rs138671819		TCGA-CV-7416-01A-11D-2078-08	TCGA-CV-7416-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	80c86be4-ccbe-4bf5-afcf-644cd337d37a	061150b2-1c4a-4126-9e7c-e9088d04db80	g.chr17:2995956_2995966delTTGTCCAGGGC	uc010vrb.1	-	1	325_335	c.325_335delGCCCTGGACAA	c.(325-336)GCCCTGGACAACfs	p.A109fs		NM_002548	NP_002539	P34982	OR1D2_HUMAN	olfactory receptor, family 1, subfamily D,	109_112	Helical; Name=3; (Potential).				cellular component movement|chemotaxis|protein import into nucleus, translocation|sensory perception of smell|single fertilization	integral to plasma membrane	olfactory receptor activity			ovary(1)	1						CAGGATGAGGTTGTCCAGGGCCACCAAGGAG	0.54		NA											22	73	---	---	---	---	NA	NA	NA	NA
SHKBP1	92799	broad.mit.edu	37	19	41086523	41086527	+	Frame_Shift_Del	DEL	GGATC	GGATC	-			TCGA-CV-7416-01A-11D-2078-08	TCGA-CV-7416-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	80c86be4-ccbe-4bf5-afcf-644cd337d37a	061150b2-1c4a-4126-9e7c-e9088d04db80	g.chr19:41086523_41086527delGGATC	uc002oob.2	+	8	663_667	c.614_618delGGATC	c.(613-618)TGGATCfs	p.W205fs	SHKBP1_uc002ooc.2_Frame_Shift_Del_p.W205fs|SHKBP1_uc002ood.2_Frame_Shift_Del_p.W205fs|SHKBP1_uc010xvl.1_Frame_Shift_Del_p.W128fs|SHKBP1_uc002ooe.2_Frame_Shift_Del_p.W42fs|SHKBP1_uc002oof.2_Frame_Shift_Del_p.W42fs|SHKBP1_uc010xvm.1_Frame_Shift_Del_p.W42fs|SHKBP1_uc010xvn.1_Frame_Shift_Del_p.W83fs	NM_138392	NP_612401	Q8TBC3	SHKB1_HUMAN	SH3KBP1 binding protein 1	205_206						voltage-gated potassium channel complex	voltage-gated potassium channel activity			ovary(1)|pancreas(1)	2			Lung(22;0.000114)|LUSC - Lung squamous cell carcinoma(20;0.000384)			CACCATAATTGGATCGCTGTGGCCT	0.595		NA											8	41	---	---	---	---	NA	NA	NA	NA
SAMHD1	25939	broad.mit.edu	37	20	35580031	35580032	+	In_Frame_Ins	INS	-	-	ATC			TCGA-CV-7416-01A-11D-2078-08	TCGA-CV-7416-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	80c86be4-ccbe-4bf5-afcf-644cd337d37a	061150b2-1c4a-4126-9e7c-e9088d04db80	g.chr20:35580031_35580032insATC	uc002xgh.1	-	1	145_146	c.15_16insGAT	c.(13-18)insGAT	p.5_6insD		NM_015474	NP_056289	Q9Y3Z3	SAMH1_HUMAN	SAM domain- and HD domain-containing protein 1	5_6					defense response to virus|innate immune response|regulation of innate immune response	nucleus	metal ion binding|phosphoric diester hydrolase activity				0		Myeloproliferative disorder(115;0.00878)				GGCTGCTCGGAATCGGCTCGCT	0.693		NA											42	282	---	---	---	---	NA	NA	NA	NA
MCAT	27349	broad.mit.edu	37	22	43539128	43539128	+	Frame_Shift_Del	DEL	C	C	-			TCGA-CV-7416-01A-11D-2078-08	TCGA-CV-7416-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	80c86be4-ccbe-4bf5-afcf-644cd337d37a	061150b2-1c4a-4126-9e7c-e9088d04db80	g.chr22:43539128delC	uc003bdl.1	-	1	276	c.227delG	c.(226-228)GGCfs	p.G76fs	MCAT_uc003bdm.1_Frame_Shift_Del_p.G76fs	NM_173467	NP_775738	Q8IVS2	FABD_HUMAN	mitochondrial malonyltransferase isoform a	76					fatty acid biosynthetic process	mitochondrion	[acyl-carrier-protein] S-malonyltransferase activity|binding			ovary(1)	1		Ovarian(80;0.0694)				GCGGCCCATGCCCACCACCTG	0.746		NA											2	4	---	---	---	---	NA	NA	NA	NA