Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	isArtifactMode	oxoGCut
MTOR	2475	broad.mit.edu	37	1	11186691	11186691	+	Missense_Mutation	SNP	A	A	T			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr1:11186691A>T	uc001asd.2	-	46	6635	c.6514T>A	c.(6514-6516)TTG>ATG	p.L2172M	MTOR_uc001asc.2_Missense_Mutation_p.L377M	NM_004958	NP_004949	P42345	MTOR_HUMAN	FK506 binding protein 12-rapamycin associated	2172					cell growth|cellular response to hypoxia|insulin receptor signaling pathway|nerve growth factor receptor signaling pathway|peptidyl-serine phosphorylation|phosphatidylinositol-mediated signaling|protein autophosphorylation|protein catabolic process|response to amino acid stimulus|response to nutrient|T cell costimulation|TOR signaling cascade	endoplasmic reticulum membrane|Golgi membrane|lysosome|mitochondrial outer membrane|phosphatidylinositol 3-kinase complex|PML body|TORC1 complex|TORC2 complex	ATP binding|phosphoprotein binding|protein serine/threonine kinase activity			central_nervous_system(7)|lung(6)|ovary(6)|skin(3)|kidney(3)|large_intestine(2)|breast(2)	29						ATAAGTGTCAATTTCCGGGGC	0.512		NA											20	29					0	0	0	0
LOC440563	440563	broad.mit.edu	37	1	13183335	13183335	+	Missense_Mutation	SNP	G	G	T			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr1:13183335G>T	uc010obg.1	-	1	633	c.538C>A	c.(538-540)CTT>ATT	p.L180I		NM_001136561	NP_001130033	B2RXH8	B2RXH8_HUMAN	heterogeneous nuclear ribonucleoprotein C-like	180						ribonucleoprotein complex	nucleic acid binding|nucleotide binding				0						ATGGCCTGAAGGTCATCTCCT	0.453		NA											88	403					4.78e-37	5.58e-37	1	0
EPHB2	2048	broad.mit.edu	37	1	23235659	23235659	+	Nonsense_Mutation	SNP	C	C	T			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr1:23235659C>T	uc009vqj.1	+	13	2642	c.2497C>T	c.(2497-2499)CAG>TAG	p.Q833*	EPHB2_uc001bge.2_Nonsense_Mutation_p.Q834*|EPHB2_uc001bgf.2_Nonsense_Mutation_p.Q833*|EPHB2_uc010odu.1_Nonsense_Mutation_p.Q775*	NM_017449	NP_059145	P29323	EPHB2_HUMAN	ephrin receptor EphB2 isoform 1 precursor	833	Cytoplasmic (Potential).|Protein kinase.				axon guidance	integral to plasma membrane	ATP binding|transmembrane-ephrin receptor activity			ovary(3)|lung(1)|pancreas(1)	5		Colorectal(325;3.46e-05)|Lung NSC(340;3.7e-05)|all_lung(284;5.45e-05)|Renal(390;0.000228)|Breast(348;0.0027)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0258)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0348)|OV - Ovarian serous cystadenocarcinoma(117;3.67e-26)|Colorectal(126;3.23e-08)|COAD - Colon adenocarcinoma(152;9.32e-07)|GBM - Glioblastoma multiforme(114;2.93e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000606)|KIRC - Kidney renal clear cell carcinoma(1967;0.00371)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.126)|Lung(427;0.153)		CATGACCAACCAGGATGTAAG	0.592		NA							Hereditary_Prostate_Cancer				15	37					0	0	0	0
ELAVL4	1996	broad.mit.edu	37	1	50642774	50642774	+	Silent	SNP	G	G	T			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr1:50642774G>T	uc001csb.2	+	3	532	c.264G>T	c.(262-264)GGG>GGT	p.G88G	ELAVL4_uc001cry.3_Silent_p.G91G|ELAVL4_uc001crz.3_Silent_p.G88G|ELAVL4_uc001csa.3_Silent_p.G105G|ELAVL4_uc001csc.3_Silent_p.G88G|ELAVL4_uc009vyu.2_Silent_p.G93G|ELAVL4_uc010omz.1_Silent_p.G93G	NM_021952	NP_068771	P26378	ELAV4_HUMAN	ELAV-like 4 isoform 1	88	RRM 1.				mRNA processing		AU-rich element binding|mRNA 3'-UTR binding|nucleotide binding			ovary(1)|pancreas(1)	2						AGAGTTTAGGGTATGGATTTG	0.274		NA											16	29					6.32e-08	6.89e-08	1	0
DOCK7	85440	broad.mit.edu	37	1	63005526	63005526	+	Missense_Mutation	SNP	T	T	A			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr1:63005526T>A	uc001daq.2	-	26	3117	c.3083A>T	c.(3082-3084)AAA>ATA	p.K1028I	DOCK7_uc001dan.2_Missense_Mutation_p.K889I|DOCK7_uc001dao.2_Missense_Mutation_p.K889I|DOCK7_uc001dap.2_Missense_Mutation_p.K997I|DOCK7_uc001dam.2_Missense_Mutation_p.K208I	NM_033407	NP_212132	Q96N67	DOCK7_HUMAN	dedicator of cytokinesis 7	1028					activation of Rac GTPase activity|axonogenesis|establishment of neuroblast polarity|microtubule cytoskeleton organization|positive regulation of peptidyl-serine phosphorylation	axon|basal part of cell|growth cone	GTP binding|guanyl-nucleotide exchange factor activity|Rac GTPase binding			ovary(2)	2						AGCCTCAAGTTTATCATTAAA	0.328		NA											10	17					0	0	0	0
GBP1	2633	broad.mit.edu	37	1	89521862	89521862	+	Missense_Mutation	SNP	G	G	A			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr1:89521862G>A	uc001dmx.2	-	8	1425	c.1205C>T	c.(1204-1206)GCA>GTA	p.A402V		NM_002053	NP_002044	P32455	GBP1_HUMAN	guanylate binding protein 1,	402					interferon-gamma-mediated signaling pathway	plasma membrane	GTP binding|GTPase activity			ovary(1)|skin(1)	2		Lung NSC(277;0.123)		all cancers(265;0.0156)|Epithelial(280;0.0291)		ATCTGATGATGCTTCCTGATT	0.413		NA											48	98					0	0	0	0
SV2A	9900	broad.mit.edu	37	1	149880767	149880767	+	Silent	SNP	A	A	T			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr1:149880767A>T	uc001etg.2	-	8	1847	c.1356T>A	c.(1354-1356)GGT>GGA	p.G452G	SV2A_uc009wlk.2_5'Flank|SV2A_uc001eth.2_Silent_p.G452G	NM_014849	NP_055664	Q7L0J3	SV2A_HUMAN	synaptic vesicle glycoprotein 2	452	Helical; (Potential).				neurotransmitter transport	cell junction|endoplasmic reticulum|integral to membrane|synaptic vesicle membrane	transmembrane transporter activity			ovary(6)|pancreas(1)	7	Breast(34;0.00769)|all_hematologic(923;0.127)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.221)|STAD - Stomach adenocarcinoma(528;0.247)		Levetiracetam(DB01202)	TGAACCACACACCCATCATCA	0.532		NA											29	41					0	0	0	0
COPA	1314	broad.mit.edu	37	1	160267363	160267363	+	Missense_Mutation	SNP	C	C	T			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr1:160267363C>T	uc009wti.2	-	20	2544	c.2150G>A	c.(2149-2151)CGC>CAC	p.R717H	COPA_uc001fvv.3_Missense_Mutation_p.R726H	NM_004371	NP_004362	P53621	COPA_HUMAN	coatomer protein complex, subunit alpha isoform	717					COPI coating of Golgi vesicle|intracellular protein transport|pancreatic juice secretion|retrograde vesicle-mediated transport, Golgi to ER	COPI vesicle coat|cytosol|extracellular space|microsome|soluble fraction	hormone activity|structural molecule activity			ovary(1)|skin(1)	2	all_cancers(52;8.15e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			CATCATCTTGCGAAGTTTTTC	0.438		NA											26	66					0	0	0	0
PTPRC	5788	broad.mit.edu	37	1	198713186	198713186	+	Nonsense_Mutation	SNP	C	C	T			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr1:198713186C>T	uc001gur.1	+	26	2875	c.2695C>T	c.(2695-2697)CAG>TAG	p.Q899*	PTPRC_uc001gus.1_Nonsense_Mutation_p.Q851*|PTPRC_uc001gut.1_Nonsense_Mutation_p.Q738*	NM_002838	NP_002829	P08575	PTPRC_HUMAN	protein tyrosine phosphatase, receptor type, C	899	Cytoplasmic (Potential).|Tyrosine-protein phosphatase 1.				axon guidance|B cell proliferation|B cell receptor signaling pathway|defense response to virus|immunoglobulin biosynthetic process|negative regulation of cytokine-mediated signaling pathway|negative regulation of protein kinase activity|negative regulation of T cell mediated cytotoxicity|positive regulation of antigen receptor-mediated signaling pathway|positive regulation of B cell proliferation|positive regulation of protein kinase activity|positive regulation of T cell proliferation|regulation of S phase|release of sequestered calcium ion into cytosol|T cell differentiation|T cell receptor signaling pathway	focal adhesion|integral to plasma membrane|membrane raft	protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			breast(4)|skin(3)|ovary(2)|lung(1)|kidney(1)|pancreas(1)	12						ATTGTAGGCCCAGTACATCTT	0.328		NA											6	25					0	0	0	0
KLHL12	59349	broad.mit.edu	37	1	202887508	202887508	+	Missense_Mutation	SNP	G	G	T			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr1:202887508G>T	uc001gyo.1	-	4	558	c.358C>A	c.(358-360)CAA>AAA	p.Q120K	KLHL12_uc001gyn.1_5'UTR|KLHL12_uc010pqc.1_Missense_Mutation_p.Q158K|KLHL12_uc009xah.1_Missense_Mutation_p.Q120K	NM_021633	NP_067646	Q53G59	KLH12_HUMAN	kelch-like 12	120					Wnt receptor signaling pathway		protein binding				0			BRCA - Breast invasive adenocarcinoma(75;0.166)			CAGCAGGCTTGTTTCACACCT	0.428		NA											26	34					3.08e-08	3.39e-08	1	0
KLHDC8A	55220	broad.mit.edu	37	1	205308854	205308854	+	Missense_Mutation	SNP	G	G	T			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr1:205308854G>T	uc001hcf.1	-	3	1027	c.459C>A	c.(457-459)GAC>GAA	p.D153E	KLHDC8A_uc010prg.1_Missense_Mutation_p.D40E|KLHDC8A_uc001hcg.1_Missense_Mutation_p.D153E	NM_018203	NP_060673	Q8IYD2	KLD8A_HUMAN	kelch domain containing 8A	153	Kelch 4.									ovary(1)	1	Breast(84;0.23)		BRCA - Breast invasive adenocarcinoma(75;0.117)			ACACCCACATGTCCTTCAGCA	0.552		NA											9	28					3.1e-07	3.35e-07	1	0
PTPN14	5784	broad.mit.edu	37	1	214585062	214585062	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr1:214585062G>A	uc001hkk.1	-	5	746	c.475C>T	c.(475-477)CAA>TAA	p.Q159*	PTPN14_uc010pty.1_Nonsense_Mutation_p.Q60*	NM_005401	NP_005392	Q15678	PTN14_HUMAN	protein tyrosine phosphatase, non-receptor type	159	FERM.		Q -> E (in a breast cancer sample; somatic mutation).		lymphangiogenesis	cytoplasm|cytoskeleton	protein tyrosine phosphatase activity|receptor tyrosine kinase binding	p.Q159E(1)		breast(2)|ovary(1)|kidney(1)|skin(1)	5				OV - Ovarian serous cystadenocarcinoma(81;0.00181)|all cancers(67;0.00194)|Epithelial(68;0.0157)|GBM - Glioblastoma multiforme(131;0.155)		AGGAAATCTTGAGAATCAAAC	0.303		NA											14	25					0	0	0	0
MIA3	375056	broad.mit.edu	37	1	222803326	222803326	+	Missense_Mutation	SNP	G	G	C			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr1:222803326G>C	uc001hnl.2	+	4	2773	c.2764G>C	c.(2764-2766)GAC>CAC	p.D922H	MIA3_uc009xea.1_Missense_Mutation_p.D758H	NM_198551	NP_940953	Q5JRA6	MIA3_HUMAN	melanoma inhibitory activity family, member 3	922	Extracellular (Potential).				exocytosis|negative regulation of cell adhesion|negative regulation of cell migration|positive regulation of leukocyte migration|protein transport|wound healing	endoplasmic reticulum membrane|integral to membrane	protein binding			ovary(4)|central_nervous_system(1)	5				GBM - Glioblastoma multiforme(131;0.0199)		CAAGAGGGAGGACTTACTTAT	0.468		NA											6	49					0	0	0	0
OR2W3	343171	broad.mit.edu	37	1	248059405	248059405	+	Nonsense_Mutation	SNP	G	G	T	rs139271211		TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr1:248059405G>T	uc001idp.1	+	3	786	c.517G>T	c.(517-519)GAG>TAG	p.E173*	OR2W3_uc010pzb.1_Nonsense_Mutation_p.E173*	NM_001001957	NP_001001957	Q7Z3T1	OR2W3_HUMAN	olfactory receptor, family 2, subfamily W,	173	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|breast(1)|pancreas(1)	3	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0319)			TGGGCACCACGAGGTGGACCA	0.657		NA											27	33					2.37e-06	2.53e-06	1	0
CAMK1D	57118	broad.mit.edu	37	10	12856261	12856261	+	Missense_Mutation	SNP	G	G	A			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr10:12856261G>A	uc001ilo.2	+	7	944	c.709G>A	c.(709-711)GAA>AAA	p.E237K	CAMK1D_uc001iln.2_Missense_Mutation_p.E237K	NM_153498	NP_705718	Q8IU85	KCC1D_HUMAN	calcium/calmodulin-dependent protein kinase ID	237	Protein kinase.					calcium- and calmodulin-dependent protein kinase complex|cytoplasm|nucleus	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			ovary(1)|stomach(1)	2				GBM - Glioblastoma multiforme(1;3.16e-05)		CCTCAAGGCGGAATATGAGTT	0.522		NA											27	26					0	0	0	0
KIAA1217	56243	broad.mit.edu	37	10	24762687	24762687	+	Silent	SNP	G	G	A			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr10:24762687G>A	uc001iru.3	+	6	1780	c.1377G>A	c.(1375-1377)CCG>CCA	p.P459P	KIAA1217_uc001irs.2_Silent_p.P379P|KIAA1217_uc001irt.3_Silent_p.P459P|KIAA1217_uc010qcy.1_Silent_p.P459P|KIAA1217_uc010qcz.1_Silent_p.P459P|KIAA1217_uc001irv.1_Silent_p.P309P|KIAA1217_uc010qda.1_RNA|KIAA1217_uc001irw.2_Silent_p.P177P|KIAA1217_uc001irz.2_Silent_p.P177P|KIAA1217_uc001irx.2_Silent_p.P177P|KIAA1217_uc001iry.2_Silent_p.P177P	NM_019590	NP_062536	Q5T5P2	SKT_HUMAN	sickle tail isoform 1	459					embryonic skeletal system development	cytoplasm				ovary(5)|skin(2)	7						GGAAATATCCGGATAGCCATT	0.502		NA											5	51					0	0	0	0
C10orf91	170393	broad.mit.edu	37	10	134261557	134261557	+	Missense_Mutation	SNP	G	G	A			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr10:134261557G>A	uc001llm.2	+	3	470	c.430G>A	c.(430-432)GAA>AAA	p.E144K		NM_173541	NP_775812	Q5T1B1	CJ091_HUMAN	hypothetical protein LOC170393	144										ovary(1)	1		all_cancers(35;6.69e-12)|all_epithelial(44;1.55e-08)|Lung NSC(174;0.000845)|all_lung(145;0.00144)|all_neural(114;0.0299)|Breast(234;0.106)|Colorectal(31;0.109)|Melanoma(40;0.123)|Glioma(114;0.203)|all_hematologic(284;0.224)		OV - Ovarian serous cystadenocarcinoma(35;6.95e-05)|Epithelial(32;0.000142)|all cancers(32;0.000162)		TGCGGCCTTCGAAGCCTGAAG	0.662		NA											22	59					0	0	0	0
KCNQ1	3784	broad.mit.edu	37	11	2799262	2799262	+	Missense_Mutation	SNP	G	G	C			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr11:2799262G>C	uc001lwn.2	+	15	1897	c.1789G>C	c.(1789-1791)GAC>CAC	p.D597H	KCNQ1_uc009ydp.1_Missense_Mutation_p.D381H|KCNQ1_uc001lwo.2_Missense_Mutation_p.D470H	NM_000218	NP_000209	P51787	KCNQ1_HUMAN	potassium voltage-gated channel, KQT-like	597	Subunits assembly domain.|Cytoplasmic (Potential).				blood circulation|membrane depolarization|muscle contraction|sensory perception of sound		delayed rectifier potassium channel activity|protein binding			ovary(1)	1		all_epithelial(84;3.26e-05)|Breast(177;0.001)|Medulloblastoma(188;0.00111)|Ovarian(85;0.00158)|all_neural(188;0.00725)|all_lung(207;0.11)|Lung NSC(207;0.159)		BRCA - Breast invasive adenocarcinoma(625;0.00251)|Lung(200;0.131)	Bepridil(DB01244)|Indapamide(DB00808)	CCGAGTAGAAGACAAGGTAGG	0.612		NA											21	39					0	0	0	0
HBD	3045	broad.mit.edu	37	11	5255582	5255582	+	Missense_Mutation	SNP	C	C	G	rs35152987	byFrequency	TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr11:5255582C>G	uc001maf.1	-	1	277	c.82G>C	c.(82-84)GCC>CCC	p.A28P		NM_000519	NP_000510	P02042	HBD_HUMAN	delta globin	28					blood coagulation	hemoglobin complex	heme binding|oxygen binding|oxygen transporter activity			ovary(1)	1		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;5.69e-10)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CTGCCCAGGGCCTCACCACCA	0.517		NA											19	38					0	0	0	0
OR6A2	8590	broad.mit.edu	37	11	6815960	6815960	+	Missense_Mutation	SNP	A	A	G			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr11:6815960A>G	uc001mes.1	-	1	1180	c.980T>C	c.(979-981)GTA>GCA	p.V327A		NM_003696	NP_003687	O95222	OR6A2_HUMAN	olfactory receptor, family 6, subfamily A,	327	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(3)|central_nervous_system(1)|pancreas(1)	5		Medulloblastoma(188;0.0523)|all_neural(188;0.236)		Epithelial(150;4.78e-08)|BRCA - Breast invasive adenocarcinoma(625;0.129)		TCCCTTCTATACATTTCTGCT	0.458		NA											30	41					0	0	0	0
NLRP14	338323	broad.mit.edu	37	11	7081185	7081185	+	Missense_Mutation	SNP	C	C	A			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr11:7081185C>A	uc001mfb.1	+	9	3017	c.2694C>A	c.(2692-2694)CAC>CAA	p.H898Q		NM_176822	NP_789792	Q86W24	NAL14_HUMAN	NLR family, pyrin domain containing 14	898					cell differentiation|multicellular organismal development|spermatogenesis		ATP binding			ovary(3)|breast(2)|pancreas(1)|lung(1)|skin(1)	8				Epithelial(150;4.62e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0871)		CTCTTCTACACAACAAGAGCC	0.443		NA											42	86					4e-26	4.65e-26	1	0
USP47	55031	broad.mit.edu	37	11	11913622	11913622	+	Silent	SNP	C	C	G			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr11:11913622C>G	uc001mjq.1	+	5	1288	c.525C>G	c.(523-525)TCC>TCG	p.S175S	USP47_uc001mjr.2_Silent_p.S87S|USP47_uc001mjs.2_Silent_p.S155S	NM_017944	NP_060414	Q96K76	UBP47_HUMAN	ubiquitin specific protease 47	175					base-excision repair|cellular response to UV|monoubiquitinated protein deubiquitination|negative regulation of apoptosis|negative regulation of caspase activity|negative regulation of G2/M transition of mitotic cell cycle|negative regulation of transcription, DNA-dependent|positive regulation of cell growth|response to drug|ubiquitin-dependent protein catabolic process	cytoplasm|SCF ubiquitin ligase complex	ubiquitin thiolesterase activity|ubiquitin-specific protease activity|WD40-repeat domain binding			ovary(1)|skin(1)	2				Epithelial(150;0.000339)		AAAGCTACTCCTACTCATCTA	0.313		NA											29	71					0	0	0	0
SPTY2D1	144108	broad.mit.edu	37	11	18636404	18636404	+	Missense_Mutation	SNP	G	G	C			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr11:18636404G>C	uc001moy.2	-	3	1633	c.1417C>G	c.(1417-1419)CAT>GAT	p.H473D	SPTY2D1_uc010rdi.1_Missense_Mutation_p.H473D	NM_194285	NP_919261	Q68D10	SPT2_HUMAN	SPT2, Suppressor of Ty, domain containing 1	473	Ser-rich.									breast(1)	1						CGAAGTTCATGTGGACTGCTC	0.622		NA											12	49					0	0	0	0
TMEM132A	54972	broad.mit.edu	37	11	60702152	60702152	+	Silent	SNP	C	C	T			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr11:60702152C>T	uc001nqj.2	+	9	1945	c.1752C>T	c.(1750-1752)CAC>CAT	p.H584H	TMEM132A_uc001nqi.2_Silent_p.H585H|TMEM132A_uc001nqm.2_Translation_Start_Site	NM_178031	NP_821174	Q24JP5	T132A_HUMAN	transmembrane protein 132A isoform b	584	Extracellular (Potential).					endoplasmic reticulum membrane|Golgi membrane|integral to membrane				skin(1)	1						TGGCGCCACACGCCCGCGTGC	0.721		NA											10	9					0	0	0	0
AHNAK	79026	broad.mit.edu	37	11	62293458	62293458	+	Missense_Mutation	SNP	T	T	C			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr11:62293458T>C	uc001ntl.2	-	5	8731	c.8431A>G	c.(8431-8433)ATC>GTC	p.I2811V	AHNAK_uc001ntk.1_Intron	NM_001620	NP_001611	Q09666	AHNK_HUMAN	AHNAK nucleoprotein isoform 1	2811					nervous system development	nucleus	protein binding			ovary(10)|pancreas(4)|skin(4)|upper_aerodigestive_tract(1)	19		Melanoma(852;0.155)				GGTCCTTCGATATTCACATCG	0.448		NA											22	153					0	0	0	0
ACY3	91703	broad.mit.edu	37	11	67412797	67412797	+	Missense_Mutation	SNP	C	C	T			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr11:67412797C>T	uc001omq.2	-	5	658	c.487G>A	c.(487-489)GAG>AAG	p.E163K		NM_080658	NP_542389	Q96HD9	ACY3_HUMAN	aspartoacylase 3	163					interspecies interaction between organisms	apical plasma membrane|cytoplasm	hydrolase activity, acting on ester bonds|metal ion binding				0					L-Aspartic Acid(DB00128)	TTGTAGCTCTCCTCCCCAGAC	0.657		NA											6	19					0	0	0	0
C11orf54	28970	broad.mit.edu	37	11	93483549	93483549	+	Silent	SNP	C	C	A			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr11:93483549C>A	uc009ywi.2	+	4	424	c.93C>A	c.(91-93)GTC>GTA	p.V31V	C11orf54_uc001pee.1_Silent_p.V31V|C11orf54_uc001pef.2_Silent_p.V31V|C11orf54_uc001peg.2_Silent_p.V31V|C11orf54_uc001peh.2_Silent_p.V31V|C11orf54_uc001pei.2_Silent_p.V12V|C11orf54_uc001pej.2_Silent_p.V12V	NM_014039	NP_054758	Q9H0W9	CK054_HUMAN	hypothetical protein LOC28970	31						nucleus	hydrolase activity, acting on ester bonds|protein binding|zinc ion binding				0		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.0123)				TTGCTGATGTCCAGGTCTCTG	0.338		NA											20	14					3.6e-14	4.08e-14	1	0
TAS2R19	259294	broad.mit.edu	37	12	11174444	11174444	+	Silent	SNP	G	G	A			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr12:11174444G>A	uc010shj.1	-	1	727	c.727C>T	c.(727-729)CTG>TTG	p.L243L	PRR4_uc009zhp.2_Intron|PRH1_uc001qzb.3_Intron|PRH1_uc001qzc.2_Intron|PRB4_uc001qzf.1_Intron|PRH1_uc001qzj.2_Intron	NM_176888	NP_795369	P59542	T2R19_HUMAN	taste receptor, type 2, member 19	243	Helical; Name=6; (Potential).				sensory perception of taste	integral to membrane	G-protein coupled receptor activity			skin(1)	1						ATTATACACAGAAAGTAAATG	0.428		NA											35	95					0	0	0	0
PLEKHA5	54477	broad.mit.edu	37	12	19501415	19501415	+	Nonsense_Mutation	SNP	C	C	A			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr12:19501415C>A	uc001reb.2	+	19	2569	c.2483C>A	c.(2482-2484)TCA>TAA	p.S828*	PLEKHA5_uc010sie.1_Nonsense_Mutation_p.S989*|PLEKHA5_uc001rea.2_Nonsense_Mutation_p.S886*|PLEKHA5_uc009zin.2_Nonsense_Mutation_p.S586*|PLEKHA5_uc010sif.1_Nonsense_Mutation_p.S817*|PLEKHA5_uc010sig.1_Nonsense_Mutation_p.S810*|PLEKHA5_uc010sih.1_Nonsense_Mutation_p.S783*|PLEKHA5_uc001rec.1_Nonsense_Mutation_p.S637*|PLEKHA5_uc009zio.2_Intron	NM_019012	NP_061885	Q9HAU0	PKHA5_HUMAN	pleckstrin homology domain containing, family A	828							1-phosphatidylinositol binding|protein binding			ovary(1)|kidney(1)|skin(1)	3	Acute lymphoblastic leukemia(4;0.000455)|all_hematologic(4;0.00804)					GAAGAAAAATCAGAACCTGTT	0.353		NA											26	36					1.34e-20	1.55e-20	1	0
KRT86	3892	broad.mit.edu	37	12	52699102	52699102	+	Missense_Mutation	SNP	G	G	C			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr12:52699102G>C	uc010snq.1	+	6	947	c.814G>C	c.(814-816)GAC>CAC	p.D272H	KRT86_uc009zmg.2_Missense_Mutation_p.D272H|KRT81_uc001sac.2_Intron|KRT86_uc001sad.2_Missense_Mutation_p.D272H	NM_002284	NP_002275	O43790	KRT86_HUMAN	keratin 86	272	Rod.|Coil 2.				cytoskeleton organization	keratin filament	structural molecule activity			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(357;0.189)		CCTGAACATGGACTGCATCAT	0.592		NA											45	72					0	0	0	0
SMARCC2	6601	broad.mit.edu	37	12	56575309	56575309	+	Missense_Mutation	SNP	G	G	C			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr12:56575309G>C	uc001skb.2	-	10	1019	c.913C>G	c.(913-915)CCT>GCT	p.P305A	SMARCC2_uc001skd.2_Missense_Mutation_p.P305A|SMARCC2_uc001ska.2_Missense_Mutation_p.P305A|SMARCC2_uc001skc.2_Missense_Mutation_p.P305A|SMARCC2_uc010sqf.1_Missense_Mutation_p.P194A	NM_003075	NP_003066	Q8TAQ2	SMRC2_HUMAN	SWI/SNF-related matrix-associated	305					chromatin remodeling|negative regulation of transcription, DNA-dependent|nervous system development|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nBAF complex|npBAF complex|nucleoplasm|SWI/SNF complex	DNA binding|protein binding|transcription coactivator activity			lung(2)|central_nervous_system(2)|ovary(1)|skin(1)	6			OV - Ovarian serous cystadenocarcinoma(18;0.123)			GTTGGTGAAGGAGAGGGGGAG	0.507		NA											27	53					0	0	0	0
LRIG3	121227	broad.mit.edu	37	12	59277366	59277366	+	Missense_Mutation	SNP	T	T	A			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr12:59277366T>A	uc001sqr.2	-	11	1498	c.1252A>T	c.(1252-1254)AGT>TGT	p.S418C	LRIG3_uc009zqh.2_Missense_Mutation_p.S358C|LRIG3_uc010ssh.1_RNA	NM_153377	NP_700356	Q6UXM1	LRIG3_HUMAN	leucine-rich repeats and immunoglobulin-like	418	LRR 15.					integral to membrane				skin(3)|ovary(1)	4			GBM - Glioblastoma multiforme(1;1.17e-18)			GCGTTGTCACTCAGGTCTCTG	0.413		NA											19	38					0	0	0	0
LIN7A	8825	broad.mit.edu	37	12	81331433	81331433	+	Silent	SNP	G	G	C			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr12:81331433G>C	uc001szj.1	-	1	262	c.69C>G	c.(67-69)CTC>CTG	p.L23L	LIN7A_uc001szk.1_RNA|MIR618_hsa-mir-618|MI0003632_5'Flank	NM_004664	NP_004655	O14910	LIN7A_HUMAN	lin-7 homolog A	23	Kinase interacting site.				exocytosis|protein complex assembly|protein transport	basolateral plasma membrane|postsynaptic density|postsynaptic membrane|synaptosome|tight junction	L27 domain binding			ovary(1)|skin(1)	2						TGTCCAGGGTGAGCGGCTGGA	0.612		NA											7	9					0	0	0	0
MED13L	23389	broad.mit.edu	37	12	116444184	116444184	+	Silent	SNP	A	A	G			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr12:116444184A>G	uc001tvw.2	-	12	2326	c.2271T>C	c.(2269-2271)ACT>ACC	p.T757T		NM_015335	NP_056150	Q71F56	MD13L_HUMAN	mediator complex subunit 13-like	757					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent					skin(4)|ovary(2)|upper_aerodigestive_tract(1)|lung(1)	8	all_neural(191;0.117)|Medulloblastoma(191;0.163)			BRCA - Breast invasive adenocarcinoma(302;0.0407)		GACCTGGTGTAGTGACATCCT	0.418		NA											23	46					0	0	0	0
TEP1	7011	broad.mit.edu	37	14	20852263	20852263	+	Silent	SNP	C	C	T			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr14:20852263C>T	uc001vxe.2	-	24	3508	c.3468G>A	c.(3466-3468)CTG>CTA	p.L1156L	TEP1_uc010ahk.2_Silent_p.L506L|TEP1_uc010tlf.1_RNA|TEP1_uc010tlg.1_Silent_p.L1048L|TEP1_uc010tlh.1_5'Flank	NM_007110	NP_009041	Q99973	TEP1_HUMAN	telomerase-associated protein 1	1156					telomere maintenance via recombination	chromosome, telomeric region|cytoplasm|nuclear matrix|soluble fraction|telomerase holoenzyme complex	ATP binding|RNA binding			ovary(5)	5	all_cancers(95;0.00123)	all_lung(585;0.235)	Epithelial(56;7.42e-08)|all cancers(55;6.46e-07)	GBM - Glioblastoma multiforme(265;0.028)|READ - Rectum adenocarcinoma(17;0.233)		GGGGCAGCATCAGCCGTTGCA	0.647		NA											36	42					0	0	0	0
JUB	84962	broad.mit.edu	37	14	23444271	23444271	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr14:23444271G>A	uc001whz.2	-	5	1658	c.1282C>T	c.(1282-1284)CGA>TGA	p.R428*	JUB_uc001why.2_Nonsense_Mutation_p.R11*	NM_032876	NP_116265	Q96IF1	JUB_HUMAN	ajuba isoform 1	428	LIM zinc-binding 2.				cell cycle|gene silencing by miRNA|positive regulation of protein complex assembly	cell-cell junction|cytoplasmic mRNA processing body|microtubule organizing center	alpha-catenin binding|zinc ion binding				0	all_cancers(95;4.6e-05)			GBM - Glioblastoma multiforme(265;0.0122)		ACAATGCATCGGAAACAGCCT	0.532		NA											52	20					0	0	0	0
SYNE2	23224	broad.mit.edu	37	14	64519707	64519707	+	Missense_Mutation	SNP	G	G	C			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr14:64519707G>C	uc001xgm.2	+	48	9306	c.9076G>C	c.(9076-9078)GAA>CAA	p.E3026Q	SYNE2_uc001xgl.2_Missense_Mutation_p.E3026Q|SYNE2_uc010apw.1_5'Flank	NM_015180	NP_055995	Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	3026	Potential.|Cytoplasmic (Potential).				centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			ovary(8)|breast(4)|central_nervous_system(1)|pancreas(1)	14				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		CCAAGTATTTGAAAAAGAAAA	0.318		NA											25	37					0	0	0	0
SYNE2	23224	broad.mit.edu	37	14	64519931	64519931	+	Missense_Mutation	SNP	G	G	C			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr14:64519931G>C	uc001xgm.2	+	48	9530	c.9300G>C	c.(9298-9300)GAG>GAC	p.E3100D	SYNE2_uc001xgl.2_Missense_Mutation_p.E3100D|SYNE2_uc010apw.1_5'Flank	NM_015180	NP_055995	Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	3100	Potential.|Cytoplasmic (Potential).				centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			ovary(8)|breast(4)|central_nervous_system(1)|pancreas(1)	14				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		TATGTGATGAGATAATAAAGA	0.333		NA											19	30					0	0	0	0
MGA	23269	broad.mit.edu	37	15	41961802	41961802	+	Missense_Mutation	SNP	C	C	T			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr15:41961802C>T	uc001zog.1	+	2	801	c.710C>T	c.(709-711)ACA>ATA	p.T237I	MGA_uc010ucy.1_Missense_Mutation_p.T237I|MGA_uc010ucz.1_Missense_Mutation_p.T237I	NM_001080541	NP_001074010	Q8IWI9	MGAP_HUMAN	MAX-interacting protein isoform 2	237	T-box.					MLL1 complex	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(6)|kidney(3)|upper_aerodigestive_tract(1)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	12		all_cancers(109;0.00356)|all_epithelial(112;0.0413)|all_lung(180;0.18)|Ovarian(310;0.238)		OV - Ovarian serous cystadenocarcinoma(18;1.41e-18)|GBM - Glioblastoma multiforme(113;2.15e-06)|COAD - Colon adenocarcinoma(120;0.031)|Lung(196;0.0721)|BRCA - Breast invasive adenocarcinoma(123;0.0964)|Colorectal(105;0.0998)|LUSC - Lung squamous cell carcinoma(244;0.235)		TTTGCAGTAACAGCTTATCAG	0.428		NA											15	19					0	0	0	0
USP8	9101	broad.mit.edu	37	15	50733619	50733619	+	Missense_Mutation	SNP	T	T	G			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr15:50733619T>G	uc001zym.3	+	4	678	c.178T>G	c.(178-180)TAT>GAT	p.Y60D	USP8_uc001zyk.1_5'UTR|USP8_uc001zyl.3_Missense_Mutation_p.Y60D|USP8_uc001zyn.3_Missense_Mutation_p.Y60D|USP8_uc010ufh.1_Intron|USP8_uc010bev.1_5'UTR	NM_001128611	NP_001122083	P40818	UBP8_HUMAN	ubiquitin specific peptidase 8	60	MIT.				cell cycle|cell proliferation|endosome organization|protein K48-linked deubiquitination|protein K63-linked deubiquitination|ubiquitin-dependent protein catabolic process	cytosol|early endosome|extrinsic to plasma membrane|nucleus	cysteine-type endopeptidase activity|SH3 domain binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			lung(1)|central_nervous_system(1)	2				all cancers(107;0.000225)|GBM - Glioblastoma multiforme(94;0.000771)		GGAAAGGGCCTATGTACTATA	0.323		NA											12	23					0	0	0	0
NR2F2	7026	broad.mit.edu	37	15	96875682	96875682	+	Silent	SNP	C	C	A			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr15:96875682C>A	uc010uri.1	+	1	1572	c.348C>A	c.(346-348)CGC>CGA	p.R116R	NR2F2_uc002btp.2_Intron|NR2F2_uc010urj.1_5'Flank|MIR1469_hsa-mir-1469|MI0007074_5'Flank|NR2F2_uc010urk.1_5'Flank	NM_021005	NP_066285	P24468	COT2_HUMAN	nuclear receptor subfamily 2, group F, member 2	116	NR C4-type.|Nuclear receptor.				lipid metabolic process|negative regulation of cyclin-dependent protein kinase activity|negative regulation of endothelial cell migration|negative regulation of endothelial cell proliferation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|regulation of transcription involved in lymphatic endothelial cell fate commitment	nucleus	ligand-regulated transcription factor activity|protein homodimerization activity|retinoic acid binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|transcription corepressor activity|zinc ion binding			ovary(2)|breast(1)	3	Lung NSC(78;0.0186)|Melanoma(26;0.0195)|all_lung(78;0.0297)		OV - Ovarian serous cystadenocarcinoma(32;0.0856)			ACACGTGCCGCGCCAACCGGA	0.602		NA											18	23					1.34e-09	1.49e-09	1	0
SPNS1	83985	broad.mit.edu	37	16	28992919	28992919	+	Silent	SNP	G	G	A			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr16:28992919G>A	uc010vdi.1	+	7	932	c.792G>A	c.(790-792)CTG>CTA	p.L264L	uc010vct.1_Intron|SPNS1_uc002drx.2_Silent_p.L191L|SPNS1_uc002dsa.2_Silent_p.L264L|SPNS1_uc002drz.2_Silent_p.L264L|SPNS1_uc010byp.2_Silent_p.L242L|SPNS1_uc010byq.1_Silent_p.L196L	NM_001142448	NP_001135920	Q9H2V7	SPNS1_HUMAN	spinster homolog 1 isoform 1	264					lipid transport|transmembrane transport	integral to membrane|mitochondrial inner membrane	protein binding				0						GGGCAGATCTGAGGGCTCTGG	0.592		NA									OREG0023712	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	31	54					0	0	0	0
RNF40	9810	broad.mit.edu	37	16	30780713	30780713	+	Silent	SNP	G	G	A			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr16:30780713G>A	uc002dzq.2	+	16	2577	c.2454G>A	c.(2452-2454)AAG>AAA	p.K818K	RNF40_uc010caa.2_Silent_p.K818K|RNF40_uc010cab.2_Silent_p.K718K|RNF40_uc010vfa.1_Silent_p.K150K|RNF40_uc002dzr.2_Silent_p.K818K|RNF40_uc010vfb.1_Silent_p.K510K|RNF40_uc010vfc.1_Silent_p.K150K	NM_014771	NP_055586	O75150	BRE1B_HUMAN	ring finger protein 40	818	Potential.				histone H2B ubiquitination|histone monoubiquitination|ubiquitin-dependent protein catabolic process	nucleus|synaptosome|ubiquitin ligase complex	protein homodimerization activity|ubiquitin protein ligase binding|zinc ion binding			central_nervous_system(1)	1			Colorectal(24;0.198)			TTGGCCTCAAGTCCCAGGTAT	0.597		NA											23	42					0	0	0	0
NUP93	9688	broad.mit.edu	37	16	56878497	56878497	+	Silent	SNP	G	G	A			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr16:56878497G>A	uc002eka.2	+	22	2557	c.2436G>A	c.(2434-2436)GTG>GTA	p.V812V	NUP93_uc002ekb.2_Silent_p.V689V|NUP93_uc010vhi.1_Silent_p.V689V	NM_014669	NP_055484	Q8N1F7	NUP93_HUMAN	nucleoporin 93kDa	812					carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear pore	protein binding			ovary(1)|lung(1)	2						CGAGGCTGGTGCAGATGGAGG	0.537		NA											22	42					0	0	0	0
GLG1	2734	broad.mit.edu	37	16	74499652	74499652	+	Silent	SNP	T	T	C			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr16:74499652T>C	uc002fcy.3	-	19	2639	c.2589A>G	c.(2587-2589)GTA>GTG	p.V863V	GLG1_uc002fcx.2_Silent_p.V863V|GLG1_uc002fcw.3_Silent_p.V852V|GLG1_uc002fcz.3_Silent_p.V280V	NM_001145667	NP_001139139	Q92896	GSLG1_HUMAN	golgi apparatus protein 1 isoform 3	863	Cys-rich GLG1 13.|Extracellular (Potential).					Golgi membrane|integral to membrane	receptor binding			ovary(1)|breast(1)	2						GCAGCTTAAATACTTTTTGGT	0.458		NA											65	194					0	0	0	0
ABR	29	broad.mit.edu	37	17	1028566	1028566	+	Silent	SNP	G	G	A	rs143549153	byFrequency	TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr17:1028566G>A	uc002fsd.2	-	2	308	c.198C>T	c.(196-198)GGC>GGT	p.G66G	ABR_uc002fse.2_Silent_p.G20G|ABR_uc010cjq.1_Silent_p.G78G	NM_021962	NP_068781	Q12979	ABR_HUMAN	active breakpoint cluster region-related	66					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|protein binding|Rho guanyl-nucleotide exchange factor activity			upper_aerodigestive_tract(1)	1				UCEC - Uterine corpus endometrioid carcinoma (25;0.0228)		CATCCCCCCCGCCCTGGCTGC	0.672		NA											44	49					0	0	0	0
MYH1	4619	broad.mit.edu	37	17	10401226	10401226	+	Missense_Mutation	SNP	A	A	T			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr17:10401226A>T	uc002gmo.2	-	31	4284	c.4190T>A	c.(4189-4191)CTG>CAG	p.L1397Q	uc002gml.1_Intron	NM_005963	NP_005954	P12882	MYH1_HUMAN	myosin, heavy chain 1, skeletal muscle, adult	1397	Potential.					muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			ovary(10)|skin(6)|breast(3)|upper_aerodigestive_tract(1)|kidney(1)	21						ACGCTGAGCCAGCTTCTTCCT	0.453		NA											5	30					0	0	0	0
AKAP10	11216	broad.mit.edu	37	17	19843030	19843030	+	Missense_Mutation	SNP	C	C	T			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr17:19843030C>T	uc002gwo.2	-	8	1455	c.1318G>A	c.(1318-1320)GAC>AAC	p.D440N	AKAP10_uc002gwp.1_Missense_Mutation_p.D440N|AKAP10_uc010cqw.1_Missense_Mutation_p.D440N	NM_007202	NP_009133	O43572	AKA10_HUMAN	A-kinase anchor protein 10 precursor	440	RGS 2.				blood coagulation|protein localization	cytosol|mitochondrion|plasma membrane	signal transducer activity			skin(1)	1	all_cancers(12;2.08e-05)|all_epithelial(12;0.00158)|Breast(13;0.165)					ACTCACTTGTCATATAAAATC	0.264		NA											15	39					0	0	0	0
CACNG1	786	broad.mit.edu	37	17	65050172	65050172	+	Missense_Mutation	SNP	T	T	A			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr17:65050172T>A	uc002jfu.2	+	2	361	c.290T>A	c.(289-291)TTC>TAC	p.F97Y		NM_000727	NP_000718	Q06432	CCG1_HUMAN	voltage-dependent calcium channel gamma-1	97					muscle contraction	voltage-gated calcium channel complex	voltage-gated calcium channel activity				0	all_cancers(12;1.04e-10)|Breast(2;1.45e-16)|all_epithelial(3;4.81e-12)				Amlodipine(DB00381)|Diltiazem(DB00343)|Ibutilide(DB00308)|Lercanidipine(DB00528)|Magnesium Sulfate(DB00653)|Nimodipine(DB00393)|Nitrendipine(DB01054)|Verapamil(DB00661)	ATCTTCGAATTCACCACTCAG	0.537		NA											29	40					0	0	0	0
ABCA9	10350	broad.mit.edu	37	17	67045471	67045471	+	Missense_Mutation	SNP	G	G	C			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr17:67045471G>C	uc002jhu.2	-	3	400	c.257C>G	c.(256-258)ACT>AGT	p.T86S	ABCA9_uc010dez.2_Missense_Mutation_p.T86S|ABCA9_uc002jhv.2_Missense_Mutation_p.T86S	NM_080283	NP_525022	Q8IUA7	ABCA9_HUMAN	ATP-binding cassette, sub-family A, member 9	86					transport	integral to membrane	ATP binding|ATPase activity			ovary(4)|upper_aerodigestive_tract(1)|central_nervous_system(1)	6	Breast(10;1.47e-12)					CTCTTGGGTAGTTTTGGATTC	0.368		NA											31	50					0	0	0	0
TTYH2	94015	broad.mit.edu	37	17	72209806	72209806	+	Missense_Mutation	SNP	T	T	C			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr17:72209806T>C	uc002jkc.2	+	1	111	c.80T>C	c.(79-81)CTG>CCG	p.L27P	TTYH2_uc010wqw.1_5'Flank|MGC16275_uc002jkb.2_5'Flank	NM_032646	NP_116035	Q9BSA4	TTYH2_HUMAN	tweety 2 isoform 1	27	Extracellular (Potential).					chloride channel complex|plasma membrane	chloride channel activity|protein binding			ovary(3)|large_intestine(1)	4						GGCCTGCGCCTGCAGCCCGTG	0.701		NA											16	16					0	0	0	0
QRICH2	84074	broad.mit.edu	37	17	74273270	74273270	+	Missense_Mutation	SNP	T	T	C			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr17:74273270T>C	uc002jrd.1	-	16	4921	c.4741A>G	c.(4741-4743)ACT>GCT	p.T1581A	QRICH2_uc010wsz.1_Intron|QRICH2_uc010dgw.1_Missense_Mutation_p.T425A	NM_032134	NP_115510	Q9H0J4	QRIC2_HUMAN	glutamine rich 2	1581							protein binding			ovary(1)|pancreas(1)|lung(1)|central_nervous_system(1)|skin(1)	5						ATCTCTTCAGTAGGATACAGG	0.637		NA											27	50					0	0	0	0
TNRC6C	57690	broad.mit.edu	37	17	76094475	76094475	+	Missense_Mutation	SNP	C	C	A			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr17:76094475C>A	uc002jud.2	+	18	4958	c.4358C>A	c.(4357-4359)ACG>AAG	p.T1453K	TNRC6C_uc002juf.2_Missense_Mutation_p.T1489K	NM_018996	NP_061869	Q9HCJ0	TNR6C_HUMAN	trinucleotide repeat containing 6C isoform 2	1453	Sufficient for translational repression when tethered to a target mRNA.				gene silencing by RNA|regulation of translation		nucleotide binding|RNA binding			ovary(1)|central_nervous_system(1)	2			BRCA - Breast invasive adenocarcinoma(99;0.00269)|Lung(188;0.0973)			ACCTCCCACACGCAAGCCTCT	0.527		NA											11	21					4.69e-08	5.13e-08	1	0
STARD6	147323	broad.mit.edu	37	18	51851189	51851189	+	Nonsense_Mutation	SNP	A	A	T			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr18:51851189A>T	uc010xdt.1	-	6	536	c.536T>A	c.(535-537)TTG>TAG	p.L179*		NM_139171	NP_631910	P59095	STAR6_HUMAN	START domain containing protein 6	179	START.				lipid transport		lipid binding			ovary(1)	1				Colorectal(16;0.021)|READ - Rectum adenocarcinoma(59;0.188)		TGATGGGGACAATTTTCCTCT	0.348		NA											19	32					0	0	0	0
ZNF558	148156	broad.mit.edu	37	19	8932738	8932738	+	Missense_Mutation	SNP	G	G	T			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr19:8932738G>T	uc002mkn.1	-	2	291	c.61C>A	c.(61-63)CAA>AAA	p.Q21K	ZNF558_uc010xkh.1_5'Flank|ZNF558_uc010dwg.1_Missense_Mutation_p.Q21K	NM_144693	NP_653294	Q96NG5	ZN558_HUMAN	zinc finger protein 558	21					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			central_nervous_system(1)	1						TGTCCTTTTTGCTGAGAGGCT	0.522		NA											3	70					0.00024832	0.000258733	1	0
DNMT1	1786	broad.mit.edu	37	19	10249209	10249209	+	Missense_Mutation	SNP	G	G	A			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr19:10249209G>A	uc002mng.2	-	34	4153	c.3973C>T	c.(3973-3975)CCT>TCT	p.P1325S	DNMT1_uc002mne.2_RNA|DNMT1_uc002mnf.2_Missense_Mutation_p.P249S|DNMT1_uc010xlc.1_Missense_Mutation_p.P1341S|DNMT1_uc002mnh.2_Missense_Mutation_p.P1220S|DNMT1_uc010xld.1_Missense_Mutation_p.P1325S	NM_001379	NP_001370	P26358	DNMT1_HUMAN	DNA (cytosine-5-)-methyltransferase 1 isoform b	1325	Catalytic.|Interaction with the PRC2/EED-EZH2 complex (By similarity).				chromatin modification|maintenance of DNA methylation|negative regulation of histone H3-K9 methylation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of gene expression|positive regulation of histone H3-K4 methylation|transcription, DNA-dependent	nucleus	DNA (cytosine-5-)-methyltransferase activity|DNA binding|transcription factor binding			ovary(2)|prostate(1)|lung(1)|breast(1)|skin(1)	6			OV - Ovarian serous cystadenocarcinoma(20;1.59e-09)|Epithelial(33;2.86e-06)|all cancers(31;6.68e-06)		Azacitidine(DB00928)|Decitabine(DB01262)|Flucytosine(DB01099)|Ifosfamide(DB01181)|Procainamide(DB01035)	GGGAACAGAGGGAGCTTCTCT	0.637		NA											10	39					0	0	0	0
KEAP1	9817	broad.mit.edu	37	19	10600446	10600446	+	Missense_Mutation	SNP	C	C	T			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr19:10600446C>T	uc002moq.1	-	4	1565	c.1409G>A	c.(1408-1410)CGT>CAT	p.R470H	KEAP1_uc002mop.1_Missense_Mutation_p.R188H|KEAP1_uc002mor.1_Missense_Mutation_p.R470H	NM_012289	NP_036421	Q14145	KEAP1_HUMAN	kelch-like ECH-associated protein 1	470	Kelch 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|midbody|nucleus	protein binding			lung(12)|breast(3)|ovary(1)|pancreas(1)	17			OV - Ovarian serous cystadenocarcinoma(20;2.71e-09)|Epithelial(33;2.32e-06)|all cancers(31;1.42e-05)			ATAAAGGAGACGATTGAGGAC	0.562		NA											15	20					0	0	0	0
LPPR2	64748	broad.mit.edu	37	19	11470232	11470232	+	Silent	SNP	C	C	T			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr19:11470232C>T	uc002mre.1	+	4	428	c.91C>T	c.(91-93)CTG>TTG	p.L31L	LPPR2_uc002mrf.1_Intron|LPPR2_uc010dxy.1_5'Flank	NM_022737	NP_073574	Q96GM1	LPPR2_HUMAN	lipid phosphate phosphatase-related protein type	31	Helical; (Potential).					integral to membrane	phosphatidate phosphatase activity			large_intestine(1)	1						CATTGTGATCCTGCTTGCTTA	0.597		NA											14	20					0	0	0	0
ZNF101	94039	broad.mit.edu	37	19	19790752	19790752	+	Silent	SNP	C	C	G			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr19:19790752C>G	uc002nni.1	+	4	1064	c.954C>G	c.(952-954)GTC>GTG	p.V318V	ZNF101_uc010ecg.1_Silent_p.V198V|ZNF101_uc002nnj.1_Silent_p.V198V	NM_033204	NP_149981	Q8IZC7	ZN101_HUMAN	zinc finger protein 101	318	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2						GTGCCAAAGTCTTTAGATGTC	0.398		NA											23	21					0	0	0	0
ZNF708	7562	broad.mit.edu	37	19	21477105	21477105	+	Silent	SNP	C	C	T			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr19:21477105C>T	uc002npq.1	-	4	861	c.663G>A	c.(661-663)GAG>GAA	p.E221E	ZNF708_uc002npr.1_Silent_p.E157E|ZNF708_uc010ecs.1_Silent_p.E157E	NM_021269	NP_067092	P17019	ZN708_HUMAN	zinc finger protein 708	221					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(4)|skin(2)	6						TGTAGGGTTTCTCTCCAGTAT	0.343		NA											5	26					0	0	0	0
ZNF99	7652	broad.mit.edu	37	19	22941528	22941528	+	Missense_Mutation	SNP	T	T	G			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr19:22941528T>G	uc010xrh.1	-	5	910	c.910A>C	c.(910-912)AAA>CAA	p.K304Q		NM_001080409	NP_001073878			zinc finger protein 99											ovary(1)|skin(1)	2		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.102)				TTGTAGGGTTTCTGTCCAGTA	0.363		NA											8	45					0	0	0	0
PPP1R15A	23645	broad.mit.edu	37	19	49379062	49379062	+	Silent	SNP	C	C	G			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr19:49379062C>G	uc002pky.3	+	3	2126	c.1857C>G	c.(1855-1857)CTC>CTG	p.L619L		NM_014330	NP_055145	O75807	PR15A_HUMAN	protein phosphatase 1, regulatory subunit 15A	619					apoptosis|cell cycle arrest|regulation of translation|response to DNA damage stimulus	endoplasmic reticulum	protein binding			lung(1)	1		all_epithelial(76;5.29e-07)|all_lung(116;1.7e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.000244)|all cancers(93;0.000694)|GBM - Glioblastoma multiforme(486;0.0222)|Epithelial(262;0.033)		GGGCACGCCTCAGGAACCCAC	0.687		NA											107	132					0	0	0	0
ZNF347	84671	broad.mit.edu	37	19	53644812	53644812	+	Silent	SNP	G	G	A			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr19:53644812G>A	uc002qbb.1	-	5	1338	c.1269C>T	c.(1267-1269)CAC>CAT	p.H423H	ZNF347_uc010eql.1_Silent_p.H424H|ZNF347_uc002qbc.1_Silent_p.H424H	NM_032584	NP_115973	Q96SE7	ZN347_HUMAN	zinc finger protein 347	423	C2H2-type 6.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				GBM - Glioblastoma multiforme(134;0.0179)		TCTCTCCAGTGTGAATTCTCC	0.428		NA											46	57					0	0	0	0
LILRA3	11026	broad.mit.edu	37	19	54802685	54802685	+	Silent	SNP	G	G	A			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr19:54802685G>A	uc002qfd.2	-	5	821	c.756C>T	c.(754-756)TAC>TAT	p.Y252Y	LILRA6_uc002qew.1_Intron|LILRA3_uc010erk.2_Silent_p.Y188Y	NM_006865	NP_006856	Q8N6C8	LIRA3_HUMAN	leukocyte immunoglobulin-like receptor,	252	Ig-like C2-type 3.				defense response	extracellular region|plasma membrane	antigen binding|receptor activity			ovary(1)	1	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		CAAATCTGTCGTAGCCGGCAT	0.627		NA											5	49					0	0	0	0
LILRA3	11026	broad.mit.edu	37	19	54802692	54802692	+	Missense_Mutation	SNP	G	G	A			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr19:54802692G>A	uc002qfd.2	-	5	814	c.749C>T	c.(748-750)GCC>GTC	p.A250V	LILRA6_uc002qew.1_Intron|LILRA3_uc010erk.2_Missense_Mutation_p.A186V	NM_006865	NP_006856	Q8N6C8	LIRA3_HUMAN	leukocyte immunoglobulin-like receptor,	250	Ig-like C2-type 3.			A -> T (in Ref. 4; AAM18037).	defense response	extracellular region|plasma membrane	antigen binding|receptor activity			ovary(1)	1	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		GTCGTAGCCGGCATCAGAGCC	0.612		NA											4	51					0	0	0	0
NRBP1	29959	broad.mit.edu	37	2	27662654	27662654	+	Nonsense_Mutation	SNP	C	C	T			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr2:27662654C>T	uc002rko.2	+	12	1757	c.925C>T	c.(925-927)CAG>TAG	p.Q309*	NRBP1_uc002rkq.2_Nonsense_Mutation_p.Q308*|NRBP1_uc002rkp.2_Nonsense_Mutation_p.Q309*|NRBP1_uc002rkr.2_Nonsense_Mutation_p.Q100*|KRTCAP3_uc002rks.2_5'Flank|KRTCAP3_uc010ylr.1_5'Flank|KRTCAP3_uc002rkt.2_5'Flank	NM_013392	NP_037524	Q9UHY1	NRBP_HUMAN	nuclear receptor binding protein	309	Protein kinase.				ER to Golgi vesicle-mediated transport|gene expression|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	cell cortex|endomembrane system|lamellipodium|membrane|nucleoplasm	ATP binding|protein homodimerization activity|protein kinase activity			ovary(2)|lung(1)	3	Acute lymphoblastic leukemia(172;0.155)					AAAGTGCCTGCAGTCTGAGCC	0.458		NA											18	133					0	0	0	0
ABCG8	64241	broad.mit.edu	37	2	44104782	44104782	+	Nonsense_Mutation	SNP	T	T	A	rs147582834	byFrequency	TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr2:44104782T>A	uc002rtq.2	+	12	1929	c.1839T>A	c.(1837-1839)TAT>TAA	p.Y613*	ABCG8_uc010yoa.1_Nonsense_Mutation_p.Y612*	NM_022437	NP_071882	Q9H221	ABCG8_HUMAN	ATP-binding cassette sub-family G member 8	613	ABC transmembrane type-2.|Extracellular (Potential).				cholesterol efflux|cholesterol homeostasis|excretion|lipid metabolic process|negative regulation of intestinal cholesterol absorption|negative regulation of intestinal phytosterol absorption	apical plasma membrane|integral to membrane	ATP binding|ATPase activity|protein heterodimerization activity			skin(3)|ovary(1)	4		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)				GAAGAACTTATAAAATGCCTC	0.522		NA									OREG0014582	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	39	33					0	0	0	0
ABCG8	64241	broad.mit.edu	37	2	44104784	44104784	+	Missense_Mutation	SNP	A	A	T			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr2:44104784A>T	uc002rtq.2	+	12	1931	c.1841A>T	c.(1840-1842)AAA>ATA	p.K614I	ABCG8_uc010yoa.1_Missense_Mutation_p.K613I	NM_022437	NP_071882	Q9H221	ABCG8_HUMAN	ATP-binding cassette sub-family G member 8	614	ABC transmembrane type-2.|Extracellular (Potential).				cholesterol efflux|cholesterol homeostasis|excretion|lipid metabolic process|negative regulation of intestinal cholesterol absorption|negative regulation of intestinal phytosterol absorption	apical plasma membrane|integral to membrane	ATP binding|ATPase activity|protein heterodimerization activity			skin(3)|ovary(1)	4		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)				AGAACTTATAAAATGCCTCTC	0.517		NA									OREG0014582	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	40	32					0	0	0	0
EGR4	1961	broad.mit.edu	37	2	73518918	73518918	+	Silent	SNP	G	G	A			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr2:73518918G>A	uc010yrj.1	-	2	1512	c.1437C>T	c.(1435-1437)CAC>CAT	p.H479H	EGR4_uc010yrk.1_Silent_p.H478H	NM_001965	NP_001956	Q05215	EGR4_HUMAN	early growth response 4	375						intracellular	nucleic acid binding|zinc ion binding				0						AGGCCTTGGCGTGCGGCCGCG	0.716		NA											5	14					0	0	0	0
THSD7B	80731	broad.mit.edu	37	2	137814025	137814025	+	Missense_Mutation	SNP	G	G	A			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr2:137814025G>A	uc002tva.1	+	2	82	c.82G>A	c.(82-84)GGA>AGA	p.G28R	THSD7B_uc010zbj.1_RNA|THSD7B_uc002tvb.2_5'UTR	NM_001080427	NP_001073896			thrombospondin, type I, domain containing 7B											ovary(4)|central_nervous_system(2)|pancreas(1)	7				BRCA - Breast invasive adenocarcinoma(221;0.19)		CTGTGGTCCCGGAGGAGTCCA	0.493		NA											16	30					0	0	0	0
RIF1	55183	broad.mit.edu	37	2	152311418	152311418	+	Missense_Mutation	SNP	G	G	A			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr2:152311418G>A	uc002txm.2	+	22	2484	c.2354G>A	c.(2353-2355)AGA>AAA	p.R785K	RIF1_uc002txl.2_Missense_Mutation_p.R785K|RIF1_uc010fnv.1_Missense_Mutation_p.R749K|RIF1_uc002txn.2_Missense_Mutation_p.R785K|RIF1_uc002txo.2_Missense_Mutation_p.R785K	NM_018151	NP_060621	Q5UIP0	RIF1_HUMAN	RAP1 interacting factor 1	785					cell cycle|response to DNA damage stimulus	chromosome, telomeric region|cytoplasm|nucleus|spindle	binding			ovary(5)|breast(4)|skin(3)|lung(2)|kidney(1)	15				BRCA - Breast invasive adenocarcinoma(221;0.0429)		GCACCACAGAGACCTTCAGAT	0.318		NA											6	34					0	0	0	0
PDE1A	5136	broad.mit.edu	37	2	183066183	183066183	+	Missense_Mutation	SNP	C	C	T			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr2:183066183C>T	uc002uos.2	-	11	1240	c.1156G>A	c.(1156-1158)GAG>AAG	p.E386K	PDE1A_uc010zfp.1_Missense_Mutation_p.E282K|PDE1A_uc002uoq.1_Missense_Mutation_p.E386K|PDE1A_uc010zfq.1_Missense_Mutation_p.E386K|PDE1A_uc002uor.2_Missense_Mutation_p.E370K|PDE1A_uc002uou.2_Missense_Mutation_p.E352K	NM_001003683	NP_001003683	P54750	PDE1A_HUMAN	phosphodiesterase 1A isoform 2	386	Catalytic (By similarity).				activation of phospholipase C activity|nerve growth factor receptor signaling pathway|platelet activation	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|calmodulin binding|calmodulin-dependent cyclic-nucleotide phosphodiesterase activity|metal ion binding			skin(2)|ovary(1)	3			OV - Ovarian serous cystadenocarcinoma(117;0.061)			AAAAACTCCTCCATTAGGGCC	0.483		NA											35	40					0	0	0	0
HECW2	57520	broad.mit.edu	37	2	197138837	197138837	+	Missense_Mutation	SNP	T	T	A			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr2:197138837T>A	uc002utm.1	-	16	3329	c.3146A>T	c.(3145-3147)GAT>GTT	p.D1049V	HECW2_uc002utl.1_Missense_Mutation_p.D693V	NM_020760	NP_065811	Q9P2P5	HECW2_HUMAN	HECT, C2 and WW domain containing E3 ubiquitin	1049	Interaction with TP73.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm	ubiquitin-protein ligase activity			skin(5)|ovary(5)|lung(4)|pancreas(2)|central_nervous_system(1)|kidney(1)	18						ATGTCGAGAATCTTCTCCTAC	0.438		NA											14	15					0	0	0	0
ALS2CR8	79800	broad.mit.edu	37	2	203817391	203817391	+	Missense_Mutation	SNP	A	A	G			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr2:203817391A>G	uc002uzo.2	+	5	696	c.416A>G	c.(415-417)AAT>AGT	p.N139S	ALS2CR8_uc002uzn.2_Missense_Mutation_p.N37S|ALS2CR8_uc002uzm.2_Missense_Mutation_p.N139S|ALS2CR8_uc010zhy.1_Missense_Mutation_p.N139S|ALS2CR8_uc010zhz.1_RNA|ALS2CR8_uc010ftu.1_RNA|ALS2CR8_uc010zia.1_Missense_Mutation_p.N63S|ALS2CR8_uc010zib.1_Missense_Mutation_p.N63S|ALS2CR8_uc010zic.1_Missense_Mutation_p.N51S|ALS2CR8_uc002uzp.2_Missense_Mutation_p.N139S	NM_001104586	NP_001098056	Q8N187	AL2S8_HUMAN	amyotrophic lateral sclerosis 2 (juvenile)	139										large_intestine(1)|ovary(1)	2						GTGGATGTGAATAGTCCTCGG	0.418		NA											30	38					0	0	0	0
ADAM33	80332	broad.mit.edu	37	20	3654911	3654911	+	Missense_Mutation	SNP	C	C	A			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr20:3654911C>A	uc002wit.2	-	7	708	c.621G>T	c.(619-621)AGG>AGT	p.R207S	ADAM33_uc002wir.1_Missense_Mutation_p.R207S|ADAM33_uc002wis.2_5'Flank|ADAM33_uc002wiu.2_Missense_Mutation_p.R207S|ADAM33_uc002wiw.1_RNA|ADAM33_uc010gba.1_Intron|ADAM33_uc010gbb.1_Intron|ADAM33_uc002wix.1_Missense_Mutation_p.R130S|ADAM33_uc010zqg.1_Missense_Mutation_p.R219S|ADAM33_uc010zqh.1_Missense_Mutation_p.R207S	NM_025220	NP_079496	Q9BZ11	ADA33_HUMAN	ADAM metallopeptidase domain 33 isoform alpha	207	Extracellular (Potential).				proteolysis	integral to membrane	metalloendopeptidase activity|zinc ion binding			large_intestine(2)|ovary(1)|skin(1)	4						ACTTCCGGGTCCTGCGCGCTT	0.642		NA											17	49					2.23e-06	2.4e-06	1	0
DEFB115	245929	broad.mit.edu	37	20	29847327	29847327	+	Missense_Mutation	SNP	G	G	C			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr20:29847327G>C	uc002wvp.1	+	2	159	c.159G>C	c.(157-159)GAG>GAC	p.E53D		NM_001037730	NP_001032819	Q30KQ5	DB115_HUMAN	beta-defensin 115 precursor	53					defense response to bacterium	extracellular region				ovary(1)	1			Colorectal(19;0.00445)|COAD - Colon adenocarcinoma(19;0.0347)			AAGAAATTGAGAGGAAGAAAG	0.353		NA											19	26					0	0	0	0
PLCG1	5335	broad.mit.edu	37	20	39797452	39797452	+	Missense_Mutation	SNP	G	G	C			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr20:39797452G>C	uc002xjp.1	+	21	2546	c.2425G>C	c.(2425-2427)GAG>CAG	p.E809Q	PLCG1_uc002xjo.1_Missense_Mutation_p.E809Q|PLCG1_uc010zwe.1_Missense_Mutation_p.E435Q|PLCG1_uc010ggf.2_Missense_Mutation_p.E133Q	NM_182811	NP_877963	P19174	PLCG1_HUMAN	phospholipase C, gamma 1 isoform b	809	SH3.				activation of phospholipase C activity|axon guidance|blood coagulation|cellular response to epidermal growth factor stimulus|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|interspecies interaction between organisms|intracellular signal transduction|leukocyte migration|nerve growth factor receptor signaling pathway|phospholipid catabolic process|positive regulation of angiogenesis|positive regulation of blood vessel endothelial cell migration|positive regulation of epithelial cell migration|T cell receptor signaling pathway	cytosol|lamellipodium|plasma membrane|ruffle	calcium ion binding|phosphatidylinositol phospholipase C activity|protein binding|receptor signaling protein activity			lung(3)|breast(3)|skin(2)	8		Myeloproliferative disorder(115;0.00878)				GAGGGAGGACGAGCTGACCTT	0.577		NA											6	17					0	0	0	0
APP	351	broad.mit.edu	37	21	27348289	27348289	+	Missense_Mutation	SNP	G	G	A			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr21:27348289G>A	uc002ylz.2	-	10	1477	c.1277C>T	c.(1276-1278)GCT>GTT	p.A426V	APP_uc010glk.2_Missense_Mutation_p.A402V|APP_uc002yma.2_Missense_Mutation_p.A407V|APP_uc011ach.1_Missense_Mutation_p.A370V|APP_uc002ymb.2_Missense_Mutation_p.A351V|APP_uc010glj.2_Missense_Mutation_p.A295V|APP_uc011aci.1_Missense_Mutation_p.A316V	NM_000484	NP_000475	P05067	A4_HUMAN	amyloid beta A4 protein isoform a precursor	426	Extracellular (Potential).				adult locomotory behavior|axon cargo transport|axon midline choice point recognition|cell adhesion|cellular copper ion homeostasis|collateral sprouting in absence of injury|dendrite development|endocytosis|extracellular matrix organization|G2 phase of mitotic cell cycle|innate immune response|ionotropic glutamate receptor signaling pathway|mating behavior|mRNA polyadenylation|neuron apoptosis|neuron remodeling|Notch signaling pathway|platelet activation|platelet degranulation|positive regulation of mitotic cell cycle|protein phosphorylation|regulation of epidermal growth factor receptor activity|regulation of multicellular organism growth|regulation of synapse structure and activity|regulation of translation|visual learning	axon|cell surface|coated pit|dendritic shaft|dendritic spine|extracellular region|Golgi apparatus|integral to plasma membrane|platelet alpha granule lumen	acetylcholine receptor binding|DNA binding|heparin binding|identical protein binding|metal ion binding|protein binding|protein binding|PTB domain binding|serine-type endopeptidase inhibitor activity			ovary(1)	1		Breast(209;0.00295)				CTTCTTATCAGCTTTAGGCAA	0.378		NA											12	34					0	0	0	0
GART	2618	broad.mit.edu	37	21	34889435	34889435	+	Silent	SNP	G	G	A			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr21:34889435G>A	uc002yrx.2	-	16	2103	c.1968C>T	c.(1966-1968)CTC>CTT	p.L656L	GART_uc002yrz.2_Silent_p.L656L|GART_uc010gmd.2_Silent_p.L318L|GART_uc002yry.2_Silent_p.L656L	NM_000819	NP_000810	P22102	PUR2_HUMAN	phosphoribosylglycinamide formyltransferase,	656	AIRS.				'de novo' IMP biosynthetic process|purine base biosynthetic process	cytosol	ATP binding|metal ion binding|methyltransferase activity|phosphoribosylamine-glycine ligase activity|phosphoribosylformylglycinamidine cyclo-ligase activity|phosphoribosylglycinamide formyltransferase activity|protein binding			ovary(1)	1					Pemetrexed(DB00642)	TGGTAGGCGTGAGAAGTAAGT	0.423		NA											70	34					0	0	0	0
CECR2	27443	broad.mit.edu	37	22	18022014	18022014	+	Nonsense_Mutation	SNP	C	C	T			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr22:18022014C>T	uc010gqw.1	+	15	2242	c.2116C>T	c.(2116-2118)CAG>TAG	p.Q706*	CECR2_uc010gqv.1_Nonsense_Mutation_p.Q565*|CECR2_uc002zml.2_Nonsense_Mutation_p.Q565*	NM_031413	NP_113601	Q9BXF3	CECR2_HUMAN	cat eye syndrome chromosome region, candidate 2	748					chromatin modification|cytokinesis|cytoskeleton organization|DNA fragmentation involved in apoptotic nuclear change|vesicle-mediated transport		protein binding			ovary(1)|skin(1)	2		all_epithelial(15;0.139)		Lung(27;0.146)		TGCTCCAGCTCAGTTCCAGCC	0.572		NA											6	12					0	0	0	0
EMID1	129080	broad.mit.edu	37	22	29627089	29627089	+	Silent	SNP	C	C	A			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr22:29627089C>A	uc003aen.2	+	6	615	c.540C>A	c.(538-540)CCC>CCA	p.P180P	EMID1_uc003aem.2_Silent_p.P182P|EMID1_uc003aeo.2_Silent_p.P182P|EMID1_uc003aep.2_Silent_p.P182P	NM_133455	NP_597712	Q96A84	EMID1_HUMAN	EMI domain containing 1	180	Collagen-like.					collagen					0						TCTGGGGTCCCCCTCCTGCCC	0.537		NA											29	48					1.75e-13	1.96e-13	1	0
FBXO7	25793	broad.mit.edu	37	22	32889111	32889111	+	Silent	SNP	A	A	G			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr22:32889111A>G	uc003amq.2	+	7	1270	c.987A>G	c.(985-987)GTA>GTG	p.V329V	FBXO7_uc003amr.2_Silent_p.V215V|FBXO7_uc003ams.2_Silent_p.V173V|FBXO7_uc003amt.2_Silent_p.V250V|FBXO7_uc003amu.2_Silent_p.V215V|FBXO7_uc003amv.2_Silent_p.V28V	NM_012179	NP_036311	Q9Y3I1	FBX7_HUMAN	F-box only protein 7 isoform 1	329	F-box.				cell death|regulation of protein stability|ubiquitin-dependent protein catabolic process	ubiquitin ligase complex	protein binding|ubiquitin-protein ligase activity			ovary(1)	1						TACCAGATGTATTTGGGTTGG	0.438		NA											42	91					0	0	0	0
OXSR1	9943	broad.mit.edu	37	3	38271893	38271893	+	Missense_Mutation	SNP	C	C	A			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr3:38271893C>A	uc003chy.2	+	10	1265	c.923C>A	c.(922-924)GCA>GAA	p.A308E	OXSR1_uc010hhb.2_Missense_Mutation_p.A242E|OXSR1_uc010hha.1_Missense_Mutation_p.A240E	NM_005109	NP_005100	O95747	OXSR1_HUMAN	oxidative-stress responsive 1	308					intracellular protein kinase cascade|response to oxidative stress		ATP binding|identical protein binding|magnesium ion binding|protein serine/threonine kinase activity			skin(1)	1				KIRC - Kidney renal clear cell carcinoma(284;0.0588)|Kidney(284;0.0738)		TTGCAGAGAGCACCAACCATT	0.289		NA											25	26					5.62e-17	6.44e-17	1	0
PHLDB2	90102	broad.mit.edu	37	3	111681154	111681154	+	Missense_Mutation	SNP	C	C	G			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr3:111681154C>G	uc010hqa.2	+	13	3483	c.3072C>G	c.(3070-3072)ATC>ATG	p.I1024M	PHLDB2_uc003dyc.2_Missense_Mutation_p.I1008M|PHLDB2_uc003dyd.2_Missense_Mutation_p.I981M|PHLDB2_uc003dyg.2_Missense_Mutation_p.I1024M|PHLDB2_uc003dyh.2_Missense_Mutation_p.I981M|PHLDB2_uc003dyi.2_Missense_Mutation_p.I515M|PHLDB2_uc003dyj.2_Missense_Mutation_p.I79M	NM_001134438	NP_001127910	Q86SQ0	PHLB2_HUMAN	pleckstrin homology-like domain, family B,	1024						cytoplasm|intermediate filament cytoskeleton|plasma membrane				ovary(4)|skin(2)	6						CAGACAACATCTCTAGGTAAG	0.438		NA											13	39					0	0	0	0
KALRN	8997	broad.mit.edu	37	3	124103785	124103785	+	Nonsense_Mutation	SNP	C	C	T			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr3:124103785C>T	uc003ehg.2	+	11	1985	c.1858C>T	c.(1858-1860)CGA>TGA	p.R620*	KALRN_uc010hrv.1_Nonsense_Mutation_p.R620*|KALRN_uc003ehf.1_Nonsense_Mutation_p.R620*|KALRN_uc011bjy.1_Nonsense_Mutation_p.R620*|KALRN_uc003ehh.1_5'UTR	NM_001024660	NP_001019831	O60229	KALRN_HUMAN	kalirin, RhoGEF kinase isoform 1	620	Spectrin 3.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|vesicle-mediated transport	actin cytoskeleton|cytosol	ATP binding|GTPase activator activity|metal ion binding|protein binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			large_intestine(2)|ovary(2)|central_nervous_system(1)|skin(1)	6						CAAGGCAGCTCGACACCTGGA	0.567		NA											23	39					0	0	0	0
PIK3CB	5291	broad.mit.edu	37	3	138431123	138431123	+	Missense_Mutation	SNP	A	A	T			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr3:138431123A>T	uc011bmq.1	-	8	1326	c.1326T>A	c.(1324-1326)AAT>AAA	p.N442K	PIK3CB_uc011bmo.1_5'UTR|PIK3CB_uc011bmp.1_Missense_Mutation_p.N46K	NM_006219	NP_006210	P42338	PK3CB_HUMAN	catalytic phosphatidylinositol 3-kinase beta	442	C2 PI3K-type.				activation of MAPK activity|chemotaxis|fibroblast growth factor receptor signaling pathway|G-protein coupled receptor protein signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell receptor signaling pathway	phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity			breast(2)|ovary(1)|lung(1)|skin(1)	5						AAACCATCGTATTTACCCACG	0.343		NA											7	21					0	0	0	0
SGEF	26084	broad.mit.edu	37	3	153840682	153840682	+	Missense_Mutation	SNP	G	G	T			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr3:153840682G>T	uc011bog.1	+	2	1112	c.901G>T	c.(901-903)GAC>TAC	p.D301Y	uc003ezu.1_5'Flank|SGEF_uc011boh.1_Missense_Mutation_p.D301Y	NM_015595	NP_056410	Q96DR7	ARHGQ_HUMAN	Src homology 3 domain-containing guanine	301					regulation of Rho protein signal transduction	intracellular|ruffle	Rho guanyl-nucleotide exchange factor activity			large_intestine(1)	1			LUSC - Lung squamous cell carcinoma(72;0.114)|Lung(72;0.173)			GGTCGATAACGACGTGGATAG	0.592		NA											5	9					1.24e-05	1.3e-05	1	0
GUF1	60558	broad.mit.edu	37	4	44684387	44684387	+	Missense_Mutation	SNP	G	G	A			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr4:44684387G>A	uc003gww.3	+	5	751	c.544G>A	c.(544-546)GCC>ACC	p.A182T	GUF1_uc010ifz.1_RNA	NM_021927	NP_068746	Q8N442	GUF1_HUMAN	GUF1 GTPase homolog	182					translation	mitochondrial inner membrane	GTP binding|GTPase activity			upper_aerodigestive_tract(1)	1						CTTCTTTCTTGCCTTCGAAGC	0.318		NA											23	69					0	0	0	0
AASDH	132949	broad.mit.edu	37	4	57244333	57244333	+	Missense_Mutation	SNP	G	G	C			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr4:57244333G>C	uc003hbn.2	-	4	802	c.649C>G	c.(649-651)CCA>GCA	p.P217A	AASDH_uc010ihb.2_5'UTR|AASDH_uc011caa.1_Missense_Mutation_p.P64A|AASDH_uc003hbo.2_Missense_Mutation_p.P117A|AASDH_uc011cab.1_Intron|AASDH_uc010ihc.2_Missense_Mutation_p.P217A|AASDH_uc003hbp.2_Missense_Mutation_p.P217A	NM_181806	NP_861522	Q4L235	ACSF4_HUMAN	aminoadipate-semialdehyde dehydrogenase	217					fatty acid metabolic process		acid-thiol ligase activity|acyl carrier activity|ATP binding|cofactor binding			ovary(4)	4	Glioma(25;0.08)|all_neural(26;0.101)	all_hematologic(202;0.0017)				TGGATATTTGGTACTATACAC	0.313		NA											32	46					0	0	0	0
CNOT6L	246175	broad.mit.edu	37	4	78641683	78641683	+	Missense_Mutation	SNP	G	G	A			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr4:78641683G>A	uc011ccd.1	-	12	1701	c.1570C>T	c.(1570-1572)CAC>TAC	p.H524Y	CNOT6L_uc003hks.2_Missense_Mutation_p.H524Y	NM_144571	NP_653172	Q96LI5	CNO6L_HUMAN	CCR4-NOT transcription complex, subunit 6-like	524					nuclear-transcribed mRNA poly(A) tail shortening	cytosol	exonuclease activity|protein binding			large_intestine(1)	1						GAAGGGATGTGAGGGTGTGGA	0.488		NA											30	131					0	0	0	0
GRID2	2895	broad.mit.edu	37	4	94377080	94377080	+	Missense_Mutation	SNP	C	C	G			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr4:94377080C>G	uc011cdt.1	+	11	2071	c.1813C>G	c.(1813-1815)CTC>GTC	p.L605V	GRID2_uc011cdu.1_Missense_Mutation_p.L510V	NM_001510	NP_001501	O43424	GRID2_HUMAN	glutamate receptor, ionotropic, delta 2	605	Cytoplasmic (Potential).				glutamate signaling pathway	cell junction|integral to plasma membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			ovary(3)|skin(2)|large_intestine(1)	6		Hepatocellular(203;0.114)|all_hematologic(202;0.177)		OV - Ovarian serous cystadenocarcinoma(123;3.22e-06)|LUSC - Lung squamous cell carcinoma(81;0.185)|Lung(65;0.191)	L-Glutamic Acid(DB00142)	GTCTACTACTCTCTACAACTC	0.403		NA											29	47					0	0	0	0
NAF1	92345	broad.mit.edu	37	4	164050333	164050333	+	Missense_Mutation	SNP	T	T	C			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr4:164050333T>C	uc003iqj.2	-	8	1395	c.1201A>G	c.(1201-1203)ATG>GTG	p.M401V	NAF1_uc010iqw.1_Intron	NM_138386	NP_612395	Q96HR8	NAF1_HUMAN	nuclear assembly factor 1 homolog isoform a	401					rRNA processing|snRNA pseudouridine synthesis	cytoplasm|nucleus|small nucleolar ribonucleoprotein complex	protein binding|snoRNA binding			ovary(2)	2	all_hematologic(180;0.166)	Prostate(90;0.109)				TGAGATACCATATGTTCTGAG	0.433		NA											21	24					0	0	0	0
DNAH5	1767	broad.mit.edu	37	5	13900460	13900460	+	Missense_Mutation	SNP	T	T	A			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr5:13900460T>A	uc003jfd.2	-	15	2156	c.2114A>T	c.(2113-2115)GAA>GTA	p.E705V		NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	705	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					TACAAACAATTCCCCTGTGCC	0.428		NA							Kartagener_syndrome				24	55					0	0	0	0
PRKAA1	5562	broad.mit.edu	37	5	40765031	40765031	+	Silent	SNP	G	G	A			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr5:40765031G>A	uc003jmc.2	-	7	1137	c.1131C>T	c.(1129-1131)TTC>TTT	p.F377F	PRKAA1_uc003jmb.2_Silent_p.F392F	NM_006251	NP_006242	Q13131	AAPK1_HUMAN	protein kinase, AMP-activated, alpha 1 catalytic	377					activation of MAPK activity|cell cycle arrest|cholesterol biosynthetic process|fatty acid biosynthetic process|insulin receptor signaling pathway|negative regulation of glucosylceramide biosynthetic process|positive regulation of anti-apoptosis|positive regulation of cholesterol biosynthetic process|regulation of fatty acid oxidation|response to hypoxia	cytosol	ATP binding|cAMP-dependent protein kinase activity|metal ion binding|protein binding			breast(1)	1					Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)|Phenformin(DB00914)	CAGCAACCAAGAATGGTACTC	0.428		NA											8	34					0	0	0	0
PRKAA1	5562	broad.mit.edu	37	5	40765109	40765109	+	Silent	SNP	G	G	A	rs116338283	by1000genomes	TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr5:40765109G>A	uc003jmc.2	-	7	1059	c.1053C>T	c.(1051-1053)TTC>TTT	p.F351F	PRKAA1_uc003jmb.2_Silent_p.F366F	NM_006251	NP_006242	Q13131	AAPK1_HUMAN	protein kinase, AMP-activated, alpha 1 catalytic	351					activation of MAPK activity|cell cycle arrest|cholesterol biosynthetic process|fatty acid biosynthetic process|insulin receptor signaling pathway|negative regulation of glucosylceramide biosynthetic process|positive regulation of anti-apoptosis|positive regulation of cholesterol biosynthetic process|regulation of fatty acid oxidation|response to hypoxia	cytosol	ATP binding|cAMP-dependent protein kinase activity|metal ion binding|protein binding			breast(1)	1					Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)|Phenformin(DB00914)	TCGCCAAATAGAAATCTTTGG	0.433		NA											18	57					0	0	0	0
ACTBL2	345651	broad.mit.edu	37	5	56777724	56777724	+	Missense_Mutation	SNP	C	C	G			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr5:56777724C>G	uc003jrm.2	-	1	913	c.811G>C	c.(811-813)GAG>CAG	p.E271Q		NM_001017992	NP_001017992	Q562R1	ACTBL_HUMAN	actin, beta-like 2	271						cytoplasm|cytoskeleton	ATP binding			ovary(3)	3		Lung NSC(810;0.000135)|Prostate(74;0.055)|Breast(144;0.0707)|Ovarian(174;0.182)		OV - Ovarian serous cystadenocarcinoma(10;4.24e-37)		CCACTGGACTCAATGCCCAGA	0.502		NA											10	30					0	0	0	0
PCDHA2	56146	broad.mit.edu	37	5	140176801	140176801	+	Missense_Mutation	SNP	C	C	G			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr5:140176801C>G	uc003lhd.2	+	1	2358	c.2252C>G	c.(2251-2253)TCG>TGG	p.S751W	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhc.1_Missense_Mutation_p.S751W|PCDHA2_uc011czy.1_Missense_Mutation_p.S751W	NM_018905	NP_061728	Q9Y5H9	PCDA2_HUMAN	protocadherin alpha 2 isoform 1 precursor	751	Cytoplasmic (Potential).|5 X 4 AA repeats of P-X-X-P.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(4)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGGTCTTACTCGCAGCAGAGG	0.667		NA											16	28					0	0	0	0
HAVCR1	26762	broad.mit.edu	37	5	156464353	156464353	+	Missense_Mutation	SNP	C	C	A			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr5:156464353C>A	uc010jij.1	-	7	1042	c.857G>T	c.(856-858)AGT>ATT	p.S286I	HAVCR1_uc011ddl.1_Missense_Mutation_p.S117I|HAVCR1_uc003lwi.2_Missense_Mutation_p.S286I	NM_001099414	NP_001092884	Q96D42	HAVR1_HUMAN	hepatitis A virus cellular receptor 1	281	Extracellular (Potential).				interspecies interaction between organisms	integral to membrane	receptor activity			ovary(1)|skin(1)	2	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.0999)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			CGTCAGTAGACTATGTTCTAG	0.398		NA											33	36					8.89e-20	1.03e-19	1	0
CNOT6	57472	broad.mit.edu	37	5	179980420	179980420	+	Missense_Mutation	SNP	C	C	G			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr5:179980420C>G	uc003mlx.2	+	4	683	c.334C>G	c.(334-336)CTA>GTA	p.L112V	CNOT6_uc010jld.2_Missense_Mutation_p.L112V|CNOT6_uc010jle.2_Missense_Mutation_p.L112V	NM_015455	NP_056270	Q9ULM6	CNOT6_HUMAN	CCR4-NOT transcription complex, subunit 6	112	LRR 3.				nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nucleus	exonuclease activity|metal ion binding|protein binding|RNA binding				0	all_cancers(89;3.3e-05)|all_epithelial(37;7.38e-06)|Renal(175;0.000159)|Lung NSC(126;0.00199)|all_lung(126;0.00351)|Breast(19;0.114)	all_cancers(40;0.00543)|Medulloblastoma(196;0.0133)|all_neural(177;0.0199)|all_hematologic(541;0.163)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	OV - Ovarian serous cystadenocarcinoma(192;0.023)		GTTACGAGTTCTACCTTTTGA	0.353		NA											5	23					0	0	0	0
RING1	6015	broad.mit.edu	37	6	33180132	33180132	+	Missense_Mutation	SNP	C	C	T			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr6:33180132C>T	uc003odk.2	+	7	1371	c.1177C>T	c.(1177-1179)CGG>TGG	p.R393W	RING1_uc003odl.2_Missense_Mutation_p.R364W	NM_002931	NP_002922	Q06587	RING1_HUMAN	ring finger protein 1	393	Necessary for interaction with CBX2 (By similarity).				histone H2A monoubiquitination|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nuclear speck|PcG protein complex	protein binding|zinc ion binding			ovary(1)|skin(1)	2						GAAGGTGTCCCGGCCACTGGA	0.478		NA											4	7					0	0	0	0
ABCC10	89845	broad.mit.edu	37	6	43413617	43413617	+	Missense_Mutation	SNP	A	A	G			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr6:43413617A>G	uc003ouy.1	+	15	3526	c.3311A>G	c.(3310-3312)TAT>TGT	p.Y1104C	ABCC10_uc003ouz.1_Missense_Mutation_p.Y1076C|ABCC10_uc010jyo.1_Missense_Mutation_p.Y210C	NM_033450	NP_258261	Q5T3U5	MRP7_HUMAN	ATP-binding cassette, sub-family C, member 10	1104	ABC transmembrane type-1 2.					integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(6)|central_nervous_system(1)	7	all_lung(25;0.00536)		Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0152)|OV - Ovarian serous cystadenocarcinoma(102;0.0804)			TCTCCACTGTATAGCCATCTG	0.637		NA											21	43					0	0	0	0
GFRAL	389400	broad.mit.edu	37	6	55223758	55223758	+	Nonsense_Mutation	SNP	C	C	A			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr6:55223758C>A	uc003pcm.1	+	6	860	c.774C>A	c.(772-774)TGC>TGA	p.C258*		NM_207410	NP_997293	Q6UXV0	GFRAL_HUMAN	GDNF family receptor alpha like precursor	258	Extracellular (Potential).					integral to membrane	receptor activity			ovary(1)|breast(1)	2	Lung NSC(77;0.0875)|Renal(3;0.122)		LUSC - Lung squamous cell carcinoma(124;0.23)			ATGAGAATTGCATTAGCACCT	0.413		NA											28	51					8.25e-16	9.41e-16	1	0
HDAC9	9734	broad.mit.edu	37	7	18688255	18688255	+	Missense_Mutation	SNP	G	G	C			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr7:18688255G>C	uc003suh.2	+	10	1448	c.1407G>C	c.(1405-1407)CAG>CAC	p.Q469H	HDAC9_uc003sue.2_Missense_Mutation_p.Q469H|HDAC9_uc011jyd.1_Missense_Mutation_p.Q469H|HDAC9_uc003sui.2_Missense_Mutation_p.Q472H|HDAC9_uc003suj.2_Missense_Mutation_p.Q428H|HDAC9_uc011jya.1_Missense_Mutation_p.Q466H|HDAC9_uc003sua.1_Missense_Mutation_p.Q447H|HDAC9_uc011jyb.1_Missense_Mutation_p.Q425H|HDAC9_uc003sud.1_Missense_Mutation_p.Q469H|HDAC9_uc011jyc.1_Missense_Mutation_p.Q428H|HDAC9_uc003suf.1_Missense_Mutation_p.Q500H|HDAC9_uc010kud.1_Missense_Mutation_p.Q472H|HDAC9_uc011jye.1_Missense_Mutation_p.Q441H|HDAC9_uc011jyf.1_Missense_Mutation_p.Q392H|HDAC9_uc010kue.1_Missense_Mutation_p.Q212H	NM_058176	NP_478056	Q9UKV0	HDAC9_HUMAN	histone deacetylase 9 isoform 1	469					B cell differentiation|cellular response to insulin stimulus|heart development|histone H3 deacetylation|histone H4 deacetylation|inflammatory response|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|peptidyl-lysine deacetylation|positive regulation of cell migration involved in sprouting angiogenesis|regulation of skeletal muscle fiber development|transcription, DNA-dependent	cytoplasm|histone deacetylase complex|histone methyltransferase complex|transcription factor complex	histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|histone deacetylase binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|protein binding|protein kinase C binding|repressing transcription factor binding|transcription corepressor activity			lung(2)|central_nervous_system(2)|kidney(1)	5	all_lung(11;0.187)				Valproic Acid(DB00313)	AGCAACACCAGCAATTCTTGG	0.498		NA											16	23					0	0	0	0
HNRNPA2B1	3181	broad.mit.edu	37	7	26232879	26232879	+	Missense_Mutation	SNP	T	T	C			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr7:26232879T>C	uc003sxr.3	-	10	1208	c.992A>G	c.(991-993)TAT>TGT	p.Y331C	HNRNPA2B1_uc003sxs.3_Missense_Mutation_p.Y319C	NM_031243	NP_112533	P22626	ROA2_HUMAN	heterogeneous nuclear ribonucleoprotein A2/B1	331	Gly-rich.|Nuclear targeting sequence (By similarity).				RNA transport	catalytic step 2 spliceosome|cytoplasm|heterogeneous nuclear ribonucleoprotein complex|nucleolus|nucleoplasm	nucleotide binding|protein binding|protein binding|RNA binding|single-stranded telomeric DNA binding			ovary(1)|central_nervous_system(1)|skin(1)	3						ACCTCCACCATATGGTCCCCC	0.358		NA	T	ETV1	prostate								29	59					0	0	0	0
SFRP4	6424	broad.mit.edu	37	7	37955807	37955807	+	Silent	SNP	G	G	A			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr7:37955807G>A	uc003tfo.3	-	1	719	c.333C>T	c.(331-333)CTC>CTT	p.L111L		NM_003014	NP_003005	Q6FHJ7	SFRP4_HUMAN	secreted frizzled-related  protein 4 precursor	111	FZ.				brain development|cell differentiation|decidualization|embryo development|epithelium development|gonad development|mammary gland involution|menstrual cycle phase|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cell proliferation|negative regulation of JNK cascade|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of sodium-dependent phosphate transport|phosphate ion homeostasis|positive regulation of apoptosis|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of epidermal cell differentiation|positive regulation of gene expression|positive regulation of receptor internalization|vasculature development|Wnt receptor signaling pathway	cell surface|cytoplasm|extracellular space|nucleus	PDZ domain binding|Wnt receptor activity|Wnt-protein binding			lung(1)	1						ACATCTTCATGAGGGGCTCGC	0.627		NA											19	33					0	0	0	0
SEMA3A	10371	broad.mit.edu	37	7	83643661	83643661	+	Missense_Mutation	SNP	T	T	A			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr7:83643661T>A	uc003uhz.2	-	7	989	c.674A>T	c.(673-675)AAG>ATG	p.K225M		NM_006080	NP_006071	Q14563	SEM3A_HUMAN	semaphorin 3A precursor	225	Sema.				axon guidance	extracellular region|membrane	receptor activity			ovary(2)|breast(1)|kidney(1)	4						ACTAATGAACTTTGGATCTGA	0.333		NA											11	11					0	0	0	0
BLK	640	broad.mit.edu	37	8	11412840	11412840	+	Splice_Site	SNP	G	G	C			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr8:11412840G>C	uc003wty.2	+	8	1201	c.620_splice	c.e8-1	p.K207_splice	BLK_uc003wtz.2_Splice_Site_p.K136_splice	NM_001715	NP_001706	P51451	BLK_HUMAN	B lymphoid tyrosine kinase						intracellular protein kinase cascade|positive regulation of insulin secretion		ATP binding|non-membrane spanning protein tyrosine kinase activity			large_intestine(1)|stomach(1)|ovary(1)	3			STAD - Stomach adenocarcinoma(15;0.00391)	COAD - Colon adenocarcinoma(149;0.207)		CCCTAATGCAGAGAAGGGGGA	0.627		NA											42	69					0	0	0	0
LZTS1	11178	broad.mit.edu	37	8	20107757	20107757	+	Missense_Mutation	SNP	G	G	A			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr8:20107757G>A	uc003wzr.2	-	3	1378	c.1267C>T	c.(1267-1269)CGG>TGG	p.R423W	LZTS1_uc010ltg.1_Missense_Mutation_p.R423W	NM_021020	NP_066300	Q9Y250	LZTS1_HUMAN	leucine zipper, putative tumor suppressor 1	423					cell cycle|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase III promoter	cell junction|dendritic spine|Golgi apparatus|nucleolus|nucleoplasm|postsynaptic density|postsynaptic membrane	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1				Colorectal(74;0.0511)|COAD - Colon adenocarcinoma(73;0.207)		AGCTTGCCCCGCGTGTCCTTC	0.647		NA											67	113					0	0	0	0
CSMD3	114788	broad.mit.edu	37	8	113871401	113871401	+	Missense_Mutation	SNP	C	C	G			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr8:113871401C>G	uc003ynu.2	-	11	1887	c.1728G>C	c.(1726-1728)TGG>TGC	p.W576C	CSMD3_uc003ynt.2_Missense_Mutation_p.W536C|CSMD3_uc011lhx.1_Missense_Mutation_p.W472C	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	576	Extracellular (Potential).|CUB 3.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						CTGTGATGACCCAGACACATT	0.373		NA								HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			27	54					0	0	0	0
SLC30A8	169026	broad.mit.edu	37	8	118170016	118170016	+	Missense_Mutation	SNP	C	C	G			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr8:118170016C>G	uc003yoh.2	+	4	735	c.505C>G	c.(505-507)CCT>GCT	p.P169A	SLC30A8_uc010mcz.2_Missense_Mutation_p.P120A|SLC30A8_uc011lia.1_Missense_Mutation_p.P120A|SLC30A8_uc003yog.2_Missense_Mutation_p.P120A	NM_173851	NP_776250	Q8IWU4	ZNT8_HUMAN	solute carrier family 30 member 8	169	Extracellular (Potential).				insulin secretion|positive regulation of insulin secretion|regulation of sequestering of zinc ion|regulation of vesicle-mediated transport|response to glucose stimulus|sequestering of zinc ion	integral to membrane|plasma membrane|secretory granule membrane|transport vesicle membrane	protein homodimerization activity|zinc ion transmembrane transporter activity			ovary(2)|skin(2)	4	all_cancers(13;2.11e-22)|Lung NSC(37;6.08e-05)|Ovarian(258;0.0173)		STAD - Stomach adenocarcinoma(47;0.203)			CCTGCTGTATCCTGATTACCA	0.552		NA											81	116					0	0	0	0
SMARCA2	6595	broad.mit.edu	37	9	2101568	2101568	+	Splice_Site	SNP	A	A	G			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr9:2101568A>G	uc003zhc.2	+	22	3178	c.3079_splice	c.e22-2	p.E1027_splice	SMARCA2_uc003zhd.2_Splice_Site_p.E1027_splice|SMARCA2_uc010mha.2_Splice_Site_p.E960_splice	NM_003070	NP_003061	P51531	SMCA2_HUMAN	SWI/SNF-related matrix-associated						chromatin remodeling|negative regulation of cell growth|negative regulation of transcription from RNA polymerase II promoter|nervous system development	intermediate filament cytoskeleton|nBAF complex|npBAF complex|nuclear chromatin|nucleoplasm|SWI/SNF complex|WINAC complex	ATP binding|DNA-dependent ATPase activity|helicase activity|protein binding|RNA polymerase II transcription coactivator activity|transcription regulatory region DNA binding			ovary(2)|central_nervous_system(1)	3		all_lung(10;2.06e-09)|Lung NSC(10;2.43e-09)		GBM - Glioblastoma multiforme(50;0.0475)		TCTCTTTTAAAGGAATCCTTT	0.274		NA											2	17					0	0	0	0
TRAF2	7186	broad.mit.edu	37	9	139815644	139815644	+	Missense_Mutation	SNP	G	G	A			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr9:139815644G>A	uc010nbu.2	+	10	1288	c.1115G>A	c.(1114-1116)CGC>CAC	p.R372H	TRAF2_uc004cjv.2_Missense_Mutation_p.R372H|TRAF2_uc011mek.1_Missense_Mutation_p.R361H|TRAF2_uc010nbw.2_Missense_Mutation_p.R347H	NM_021138	NP_066961	Q12933	TRAF2_HUMAN	TNF receptor-associated factor 2	372	MATH.				activation of caspase activity|activation of NF-kappaB-inducing kinase activity|activation of pro-apoptotic gene products|cellular protein complex assembly|induction of apoptosis by extracellular signals|positive regulation of interleukin-2 production|positive regulation of JUN kinase activity|positive regulation of NF-kappaB transcription factor activity|positive regulation of T cell cytokine production|protein autoubiquitination|protein homotrimerization|protein K63-linked ubiquitination|tumor necrosis factor-mediated signaling pathway	CD40 receptor complex|cytosol|internal side of plasma membrane	CD40 receptor binding|enzyme binding|protein binding|signal transducer activity|sphingolipid binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|lung(1)|breast(1)|skin(1)	4	all_cancers(76;0.11)	Myeloproliferative disorder(178;0.0511)	STAD - Stomach adenocarcinoma(284;0.229)	OV - Ovarian serous cystadenocarcinoma(145;4.48e-06)|Epithelial(140;9.55e-06)		GTGGCTGGCCGCATACCCGCC	0.592		NA											4	63					0	0	0	0
PLCXD1	55344	broad.mit.edu	37	X	208211	208211	+	Missense_Mutation	SNP	G	G	A			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chrX:208211G>A	uc004cpc.2	+	5	751	c.439G>A	c.(439-441)GAG>AAG	p.E147K	PLCXD1_uc011mgx.1_RNA	NM_018390	NP_060860	Q9NUJ7	PLCX1_HUMAN	phosphatidylinositol-specific phospholipase C, X	147	PI-PLC X-box.				intracellular signal transduction|lipid metabolic process		phospholipase C activity				0		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				GCATCCACGCGAGGTGGTCAT	0.607		NA											16	46					0	0	0	0
GUCY2F	2986	broad.mit.edu	37	X	108641866	108641866	+	Missense_Mutation	SNP	A	A	C	rs113612238		TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chrX:108641866A>C	uc004eod.3	-	11	2463	c.2187T>G	c.(2185-2187)TTT>TTG	p.F729L	GUCY2F_uc011msq.1_RNA	NM_001522	NP_001513	P51841	GUC2F_HUMAN	guanylate cyclase 2F precursor	729	Protein kinase.|Cytoplasmic (Potential).				intracellular signal transduction|receptor guanylyl cyclase signaling pathway|visual perception	integral to plasma membrane|nuclear outer membrane	ATP binding|GTP binding|guanylate cyclase activity|protein kinase activity|receptor activity			lung(4)|breast(3)|central_nervous_system(1)	8						CATCTCCTGCAAAAGAACCTA	0.502		NA											25	11					0	0	0	0
FMR1	2332	broad.mit.edu	37	X	147014272	147014272	+	Missense_Mutation	SNP	G	G	T			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chrX:147014272G>T	uc010nst.2	+	9	1059	c.870G>T	c.(868-870)AGG>AGT	p.R290S	FMR1_uc011mwz.1_Missense_Mutation_p.R290S|FMR1_uc004fcj.2_Missense_Mutation_p.R290S|FMR1_uc004fck.3_Missense_Mutation_p.R290S|FMR1_uc004fcl.3_Missense_Mutation_p.R151S|FMR1_uc011mxa.1_5'UTR	NM_002024	NP_002015	Q06787	FMR1_HUMAN	fragile X mental retardation 1	290	KH 2.				mRNA transport|negative regulation of translational initiation	cytoplasm|mRNA cap binding complex|nucleolus|nucleoplasm|soluble fraction	mRNA binding|protein binding			ovary(2)|pancreas(1)	3	Acute lymphoblastic leukemia(192;6.56e-05)					AAGTTCCAAGGAACTTAGTAG	0.318		NA							Fragile_X_syndrome				6	38					0.00116845	0.00121353	1	0
IPO8	10526	broad.mit.edu	37	12	30787082	30787082	+	Frame_Shift_Del	DEL	A	A	-			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr12:30787082delA	uc001rjd.2	-	23	3004	c.2834delT	c.(2833-2835)TTCfs	p.F945fs	IPO8_uc001rje.1_Frame_Shift_Del_p.F434fs|IPO8_uc010sjt.1_Frame_Shift_Del_p.F740fs	NM_006390	NP_006381	O15397	IPO8_HUMAN	importin 8	945					intracellular protein transport|signal transduction	cytoplasm|nucleus	protein transporter activity|Ran GTPase binding			skin(2)|central_nervous_system(1)	3	all_lung(12;6.66e-10)|Lung NSC(12;4.84e-08)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0355)|Lung SC(12;0.0905)|Esophageal squamous(101;0.233)					TGGAGTACTGAACCCCTCAAG	0.413		NA											28	38	---	---	---	---	NA	NA	NA	NA
GPR172B	55065	broad.mit.edu	37	17	4936879	4936880	+	Frame_Shift_Ins	INS	-	-	T			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr17:4936879_4936880insT	uc002gap.3	-	3	1617_1618	c.904_905insA	c.(904-906)AGCfs	p.S302fs	GPR172B_uc002gao.3_Frame_Shift_Ins_p.S302fs|GPR172B_uc010ckw.2_Frame_Shift_Ins_p.S180fs|GPR172B_uc010ckx.2_Frame_Shift_Ins_p.S302fs	NM_001104577	NP_001098047	Q9NWF4	RFT_HUMAN	G protein-coupled receptor 172B precursor	302						integral to plasma membrane	receptor activity|riboflavin transporter activity				0						ACAGGAAAAGCTCTGCACAGAA	0.644		NA											19	28	---	---	---	---	NA	NA	NA	NA
TP53	7157	broad.mit.edu	37	17	7578398	7578398	+	Frame_Shift_Del	DEL	G	G	-	rs68130327		TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr17:7578398delG	uc002gim.2	-	5	726	c.532delC	c.(532-534)CACfs	p.H178fs	TP53_uc002gig.1_Frame_Shift_Del_p.H178fs|TP53_uc002gih.2_Frame_Shift_Del_p.H178fs|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Frame_Shift_Del_p.H46fs|TP53_uc010cng.1_Frame_Shift_Del_p.H46fs|TP53_uc002gii.1_Frame_Shift_Del_p.H46fs|TP53_uc010cnh.1_Frame_Shift_Del_p.H178fs|TP53_uc010cni.1_Frame_Shift_Del_p.H178fs|TP53_uc002gij.2_Frame_Shift_Del_p.H178fs|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Frame_Shift_Del_p.H85fs|TP53_uc002gio.2_Frame_Shift_Del_p.H46fs|TP53_uc010vug.1_Frame_Shift_Del_p.H139fs	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	178	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		H -> L (in a sporadic cancer; somatic mutation).|H -> Y (in sporadic cancers; somatic mutation).|H -> P (in sporadic cancers; somatic mutation).|HH -> QS (in a sporadic cancer; somatic mutation).|H -> Q (in sporadic cancers; somatic mutation).|H -> N (in sporadic cancers; somatic mutation).|H -> HPHP (in a Burkitt lymphoma).|H -> D (in sporadic cancers; somatic mutation).|H -> R (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.H178fs*69(13)|p.P177_C182delPHHERC(8)|p.H178Y(8)|p.0?(7)|p.H178P(6)|p.H178fs*3(5)|p.H178Q(5)|p.H178D(4)|p.C176_R181delCPHHER(3)|p.R174fs*24(3)|p.R175_E180delRCPHHE(3)|p.H178N(3)|p.P177fs*3(2)|p.V173fs*59(2)|p.R174fs*1(2)|p.H178H(2)|p.K164_P219del(1)|p.C176fs*65(1)|p.V173fs*69(1)|p.C176fs*68(1)|p.P177_H179delPHH(1)|p.V173fs*23(1)|p.R174_H178>S(1)|p.V172_E180delVVRRCPHHE(1)|p.R174_H179delRRCPHH(1)|p.E171fs*1(1)|p.P177fs*69(1)|p.R175_H178>X(1)|p.H178_H179>QY(1)|p.H168fs*69(1)|p.E171_H179delEVVRRCPHH(1)|p.R81fs*24(1)|p.H178del(1)|p.R174_E180>K(1)|p.H178fs*6(1)|p.P177_E180delPHHE(1)|p.R42fs*24(1)|p.H178L(1)|p.R174fs*3(1)|p.E171fs*61(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CGCTCATGGTGGGGGCAGCGC	0.642		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			23	22	---	---	---	---	NA	NA	NA	NA
SIPA1L3	23094	broad.mit.edu	37	19	38590721	38590721	+	Frame_Shift_Del	DEL	C	C	-			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr19:38590721delC	uc002ohk.2	+	5	2294	c.1785delC	c.(1783-1785)ATCfs	p.I595fs		NM_015073	NP_055888	O60292	SI1L3_HUMAN	signal-induced proliferation-associated 1 like	595					regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			ovary(1)|central_nervous_system(1)	2			Lung(45;0.000246)|LUSC - Lung squamous cell carcinoma(53;0.000292)			AGCTCAACATCCACTGCCTGC	0.642		NA											36	35	---	---	---	---	NA	NA	NA	NA
PLSCR4	57088	broad.mit.edu	37	3	145913053	145913053	+	Frame_Shift_Del	DEL	C	C	-			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr3:145913053delC	uc010huy.2	-	8	1132	c.803delG	c.(802-804)GGCfs	p.G268fs	PLSCR4_uc010huz.2_Frame_Shift_Del_p.G268fs|PLSCR4_uc003evt.3_Frame_Shift_Del_p.G268fs|PLSCR4_uc010hva.2_Frame_Shift_Del_p.G178fs|PLSCR4_uc003evu.3_Frame_Shift_Del_p.G163fs	NM_001128305	NP_001121777	Q9NRQ2	PLS4_HUMAN	phospholipid scramblase 4 isoform a	268	Cytoplasmic (By similarity).				blood coagulation|phospholipid scrambling	integral to membrane	calcium ion binding|phospholipid scramblase activity|SH3 domain binding				0						GTTGGATATGCCATCAAGGGA	0.398		NA											36	38	---	---	---	---	NA	NA	NA	NA
CDO1	1036	broad.mit.edu	37	5	115148957	115148958	+	Splice_Site	INS	-	-	A			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr5:115148957_115148958insA	uc003krg.2	-	2	482	c.171_splice	c.e2-1	p.R57_splice		NM_001801	NP_001792	Q16878	CDO1_HUMAN	cysteine dioxygenase						inflammatory response|sulfur amino acid biosynthetic process|taurine biosynthetic process	cytosol	cysteine dioxygenase activity			large_intestine(1)|skin(1)	2		all_cancers(142;0.0046)|all_epithelial(76;0.000161)|Prostate(80;0.0132)|Ovarian(225;0.0776)		OV - Ovarian serous cystadenocarcinoma(64;7.8e-08)|Epithelial(69;7.32e-07)|all cancers(49;3.24e-05)	L-Cysteine(DB00151)|NADH(DB00157)	CGGGTATACCTAAAAAAAAACA	0.332		NA											8	21	---	---	---	---	NA	NA	NA	NA
LGI3	203190	broad.mit.edu	37	8	22013886	22013889	+	Frame_Shift_Del	DEL	GCCT	GCCT	-			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr8:22013886_22013889delGCCT	uc003xav.2	-	1	456_459	c.167_170delAGGC	c.(166-171)AAGGCGfs	p.K56fs	SFTPC_uc003xaw.3_5'Flank|LGI3_uc010ltu.2_Frame_Shift_Del_p.K56fs	NM_139278	NP_644807	Q8N145	LGI3_HUMAN	leucine-rich repeat LGI family, member 3	56_57	LRRNT.				exocytosis	cell junction|extracellular region|synaptic vesicle|synaptosome				ovary(1)	1				Colorectal(74;0.00189)|COAD - Colon adenocarcinoma(73;0.0612)|READ - Rectum adenocarcinoma(644;0.0999)		CCTGGGCACCGCCTTTGAGTCCAC	0.672		NA											8	23	---	---	---	---	NA	NA	NA	NA