Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
DCUN1D1	54165	broad.mit.edu	37	3	182665102	182665102	+	Silent	SNP	T	T	G			TCGA-BA-A4IG-01A-11D-A25Y-08	TCGA-BA-A4IG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	200d5ad1-bd1f-4068-a4e4-4b6a3aaaf92d	df122b02-6d09-4441-af8a-cae70fd20fff	g.chr3:182665102T>G	ENST00000292782.4	-	6	777	c.624A>C	c.(622-624)atA>atC	p.I208I	DCUN1D1_ENST00000469954.1_Silent_p.I193I	NM_020640.2	NP_065691.2	Q96GG9	DCNL1_HUMAN	DCN1, defective in cullin neddylation 1, domain containing 1	208	DCUN1.					ubiquitin ligase complex	protein binding			endometrium(2)|large_intestine(4)|lung(8)|ovary(1)	15	all_cancers(143;9.04e-15)|Ovarian(172;0.0355)		all cancers(12;2.54e-44)|Epithelial(37;4.71e-38)|LUSC - Lung squamous cell carcinoma(7;5.04e-25)|Lung(8;5.03e-23)|OV - Ovarian serous cystadenocarcinoma(80;7.41e-21)			TGTCTTTTGGTATTGATCGTT	0.303000													4	40					0	0	1	0	0
TMC8	147138	broad.mit.edu	37	17	76133869	76133869	+	Silent	SNP	C	C	T			TCGA-BA-A4IG-01A-11D-A25Y-08	TCGA-BA-A4IG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	200d5ad1-bd1f-4068-a4e4-4b6a3aaaf92d	df122b02-6d09-4441-af8a-cae70fd20fff	g.chr17:76133869C>T	ENST00000318430.5	+	11	1697	c.1323C>T	c.(1321-1323)ttC>ttT	p.F441F	TMC8_ENST00000589691.1_Silent_p.F218F	NM_152468.4	NP_689681.2	Q8IU68	TMC8_HUMAN	transmembrane channel-like 8	441						endoplasmic reticulum membrane|integral to membrane				breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(2)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	12			BRCA - Breast invasive adenocarcinoma(99;0.00269)|Lung(188;0.0973)|OV - Ovarian serous cystadenocarcinoma(97;0.192)			CCGTGGCCTTCGCCTTCCTGG	0.662000													12	75					0	0	1	0	0
PMS2CL	441194	broad.mit.edu	37	7	6776956	6776956	+	RNA	SNP	A	A	G	rs7804542	by1000genomes	TCGA-BA-A4IG-01A-11D-A25Y-08	TCGA-BA-A4IG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	200d5ad1-bd1f-4068-a4e4-4b6a3aaaf92d	df122b02-6d09-4441-af8a-cae70fd20fff	g.chr7:6776956A>G	ENST00000486256.1	+	0	1083					NR_002217.1																						ATCTCTGACAAAGGCGTCCTG	0.557000													5	71					0	0	1	0	0
C9orf84	158401	broad.mit.edu	37	9	114500747	114500747	+	Silent	SNP	T	T	A			TCGA-BA-A4IG-01A-11D-A25Y-08	TCGA-BA-A4IG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	200d5ad1-bd1f-4068-a4e4-4b6a3aaaf92d	df122b02-6d09-4441-af8a-cae70fd20fff	g.chr9:114500747T>A	ENST00000394779.3	-	8	1165	c.921A>T	c.(919-921)atA>atT	p.I307I	C9orf84_ENST00000374287.3_Silent_p.I346I|C9orf84_ENST00000394777.4_Silent_p.I307I|C9orf84_ENST00000374283.5_Silent_p.I410I|C9orf84_ENST00000318737.4_Silent_p.I346I	NM_001080551.1	NP_001074020.1	Q5VXU9	CI084_HUMAN	chromosome 9 open reading frame 84	346										breast(1)|cervix(1)|endometrium(3)|kidney(7)|large_intestine(10)|liver(1)|lung(7)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	35						TAACAGAAAATATCTTTTTCA	0.333000													32	92					0	0	1	0	0
MYO3A	53904	broad.mit.edu	37	10	26463414	26463414	+	Silent	SNP	G	G	A			TCGA-BA-A4IG-01A-11D-A25Y-08	TCGA-BA-A4IG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	200d5ad1-bd1f-4068-a4e4-4b6a3aaaf92d	df122b02-6d09-4441-af8a-cae70fd20fff	g.chr10:26463414G>A	ENST00000265944.5	+	30	4387	c.4221G>A	c.(4219-4221)aaG>aaA	p.K1407K	MYO3A_ENST00000543632.1_Intron	NM_017433.4	NP_059129.3	Q8NEV4	MYO3A_HUMAN	myosin IIIA	1407					protein autophosphorylation|response to stimulus|sensory perception of sound|visual perception	cytoplasm|filamentous actin|filopodium|myosin complex	actin binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|plus-end directed microfilament motor activity|protein serine/threonine kinase activity			NS(2)|breast(9)|central_nervous_system(3)|endometrium(9)|kidney(10)|large_intestine(28)|liver(1)|lung(46)|ovary(11)|pancreas(1)|prostate(6)|skin(11)|stomach(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	146						ATAACATCAAGAAGAAGGATA	0.328000													28	79					0	0	1	0	0
CUBN	8029	broad.mit.edu	37	10	16873292	16873292	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-A4IG-01A-11D-A25Y-08	TCGA-BA-A4IG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	200d5ad1-bd1f-4068-a4e4-4b6a3aaaf92d	df122b02-6d09-4441-af8a-cae70fd20fff	g.chr10:16873292G>A	ENST00000377833.4	-	65	10552	c.10487C>T	c.(10486-10488)tCt>tTt	p.S3496F		NM_001081.3	NP_001072.2	O60494	CUBN_HUMAN	cubilin (intrinsic factor-cobalamin receptor)	3496	CUB 26.				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			breast(8)|central_nervous_system(4)|cervix(1)|endometrium(18)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(42)|liver(1)|lung(107)|ovary(9)|pancreas(2)|prostate(3)|skin(9)|stomach(3)|upper_aerodigestive_tract(11)|urinary_tract(8)	241					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	TCCACGATCAGAAGTTACACT	0.403000													22	70					0	0	1	0	0
DGKB	1607	broad.mit.edu	37	7	14647094	14647094	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-A4IG-01A-11D-A25Y-08	TCGA-BA-A4IG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	200d5ad1-bd1f-4068-a4e4-4b6a3aaaf92d	df122b02-6d09-4441-af8a-cae70fd20fff	g.chr7:14647094C>A	ENST00000403951.2	-	17	1820	c.1401G>T	c.(1399-1401)caG>caT	p.Q467H	DGKB_ENST00000402815.1_Missense_Mutation_p.Q466H|DGKB_ENST00000403963.1_5'UTR|DGKB_ENST00000258767.5_Missense_Mutation_p.Q467H|DGKB_ENST00000407950.1_Missense_Mutation_p.Q459H|DGKB_ENST00000444700.2_Missense_Mutation_p.Q448H|DGKB_ENST00000406247.3_Missense_Mutation_p.Q467H|DGKB_ENST00000399322.3_Missense_Mutation_p.Q467H			Q9Y6T7	DGKB_HUMAN	diacylglycerol kinase, beta 90kDa	467	DAGKc.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	cytoplasm|plasma membrane	ATP binding|calcium ion binding|diacylglycerol kinase activity|protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|liver(1)|lung(34)|ovary(4)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	72					Phosphatidylserine(DB00144)	GACTGTAAACCTGACGAGGAT	0.284000													6	31					0.00307968	0.00318587	1	1	0
EIF2B3	8891	broad.mit.edu	37	1	45407265	45407265	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-A4IG-01A-11D-A25Y-08	TCGA-BA-A4IG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	200d5ad1-bd1f-4068-a4e4-4b6a3aaaf92d	df122b02-6d09-4441-af8a-cae70fd20fff	g.chr1:45407265C>T	ENST00000360403.2	-	4	493	c.367G>A	c.(367-369)Gct>Act	p.A123T	EIF2B3_ENST00000480675.1_5'UTR|EIF2B3_ENST00000372183.3_Missense_Mutation_p.A123T	NM_001261418.1|NM_020365.4	NP_001248347.1|NP_065098.1	Q9NR50	EI2BG_HUMAN	eukaryotic translation initiation factor 2B, subunit 3 gamma, 58kDa	123					negative regulation of translational initiation in response to stress|oligodendrocyte development|response to glucose stimulus|response to heat|response to peptide hormone stimulus	cytosol|eukaryotic translation initiation factor 2B complex	nucleotidyltransferase activity|protein binding|translation initiation factor activity			endometrium(2)|large_intestine(3)|lung(10)|ovary(1)|prostate(1)	17	Acute lymphoblastic leukemia(166;0.155)					GCATCATAAGCTCTAAACAGG	0.428000													20	149					0	0	1	0	0
TMEM181	57583	broad.mit.edu	37	6	158957802	158957802	+	Silent	SNP	C	C	G			TCGA-BA-A4IG-01A-11D-A25Y-08	TCGA-BA-A4IG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	200d5ad1-bd1f-4068-a4e4-4b6a3aaaf92d	df122b02-6d09-4441-af8a-cae70fd20fff	g.chr6:158957802C>G	ENST00000367090.3	+	1	335	c.324C>G	c.(322-324)ctC>ctG	p.L108L		NM_020823.1	NP_065874.1	Q9P2C4	TM181_HUMAN	transmembrane protein 181	108					pathogenesis	integral to membrane	toxin binding			central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(4)|lung(8)|ovary(2)|skin(1)	22		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;8.15e-18)|BRCA - Breast invasive adenocarcinoma(81;1.38e-05)		AGCCCCCGCTCTGCAGCGAGC	0.701000													4	16					0	0	1	0	0
EIF6	3692	broad.mit.edu	37	20	33872144	33872144	+	Silent	SNP	C	C	G			TCGA-BA-A4IG-01A-11D-A25Y-08	TCGA-BA-A4IG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	200d5ad1-bd1f-4068-a4e4-4b6a3aaaf92d	df122b02-6d09-4441-af8a-cae70fd20fff	g.chr20:33872144C>G	ENST00000374443.3	-	2	196	c.147G>C	c.(145-147)gcG>gcC	p.A49A	EIF6_ENST00000462894.1_Intron|EIF6_ENST00000374436.3_Intron|EIF6_ENST00000374450.3_Intron	NM_181466.2	NP_852131.1	P56537	IF6_HUMAN	eukaryotic translation initiation factor 6	52					mature ribosome assembly	cytoplasm|nucleolus	protein binding|ribosome binding|translation initiation factor activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(3)|pancreas(1)|skin(1)	9			BRCA - Breast invasive adenocarcinoma(18;0.00252)			CTCCTGCGCACGCCTCCCCGC	0.662000													20	104					0	0	1	0	0
ZC3H4	23211	broad.mit.edu	37	19	47588319	47588319	+	Silent	SNP	G	G	A			TCGA-BA-A4IG-01A-11D-A25Y-08	TCGA-BA-A4IG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	200d5ad1-bd1f-4068-a4e4-4b6a3aaaf92d	df122b02-6d09-4441-af8a-cae70fd20fff	g.chr19:47588319G>A	ENST00000253048.5	-	8	1138	c.1101C>T	c.(1099-1101)gaC>gaT	p.D367D	ZC3H4_ENST00000594019.1_Intron	NM_015168.1	NP_055983.1	Q9UPT8	ZC3H4_HUMAN	zinc finger CCCH-type containing 4	367	Gly-rich.						nucleic acid binding|zinc ion binding			NS(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(6)|lung(13)|ovary(4)|prostate(2)|skin(7)|upper_aerodigestive_tract(1)	41		all_cancers(25;3.3e-08)|all_epithelial(76;2.28e-06)|all_lung(116;7.86e-06)|Lung NSC(112;2.31e-05)|all_neural(266;0.026)|Ovarian(192;0.0392)|Breast(70;0.0889)		OV - Ovarian serous cystadenocarcinoma(262;5.76e-05)|all cancers(93;7.69e-05)|Epithelial(262;0.00354)|GBM - Glioblastoma multiforme(486;0.0372)		TCACGCCCATGTCCTCGTCAT	0.537000													12	256					0	0	1	0	0
ATP8B1	5205	broad.mit.edu	37	18	55361887	55361887	+	Missense_Mutation	SNP	A	A	G			TCGA-BA-A4IG-01A-11D-A25Y-08	TCGA-BA-A4IG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	200d5ad1-bd1f-4068-a4e4-4b6a3aaaf92d	df122b02-6d09-4441-af8a-cae70fd20fff	g.chr18:55361887A>G	ENST00000536015.1	-	11	1075	c.956T>C	c.(955-957)aTa>aCa	p.I319T	RP11-35G9.5_ENST00000588925.1_RNA|ATP8B1_ENST00000283684.4_Missense_Mutation_p.I319T|RP11-35G9.3_ENST00000599199.1_RNA	NM_005603.4	NP_005594.1	O43520	AT8B1_HUMAN	ATPase, aminophospholipid transporter, class I, type 8B, member 1	319					ATP biosynthetic process|bile acid and bile salt transport|negative regulation of transcription, DNA-dependent	apical plasma membrane|integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			breast(6)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(11)|lung(19)|ovary(3)|prostate(1)	53		Colorectal(73;0.229)				ATTCTTCATTATTTTAGTGTC	0.328000													6	20					0	0	1	0	0
PALB2	79728	broad.mit.edu	37	16	23646717	23646717	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-A4IG-01A-11D-A25Y-08	TCGA-BA-A4IG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	200d5ad1-bd1f-4068-a4e4-4b6a3aaaf92d	df122b02-6d09-4441-af8a-cae70fd20fff	g.chr16:23646717C>T	ENST00000261584.4	-	4	1302	c.1150G>A	c.(1150-1152)Gaa>Aaa	p.E384K		NM_024675.3	NP_078951.2	Q86YC2	PALB2_HUMAN	partner and localizer of BRCA2	384					double-strand break repair via homologous recombination	nucleoplasm	DNA binding|protein binding			breast(5)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(11)|lung(21)|ovary(3)|pancreas(1)|prostate(3)|skin(1)|stomach(1)|urinary_tract(3)	55				GBM - Glioblastoma multiforme(48;0.0167)		GAGGTTGCTTCCAGGCTAAGA	0.413000			"""F, N, Mis"""			"""Wilms tumor, medulloblastoma, AML ,breast"""		Involved in tolerance or repair of DNA crosslinks					16	112					0	0	1	0	0
BCAR1	9564	broad.mit.edu	37	16	75263550	75263550	+	Silent	SNP	G	G	T			TCGA-BA-A4IG-01A-11D-A25Y-08	TCGA-BA-A4IG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	200d5ad1-bd1f-4068-a4e4-4b6a3aaaf92d	df122b02-6d09-4441-af8a-cae70fd20fff	g.chr16:75263550G>T	ENST00000546196.1	-	7	4037	c.2385C>A	c.(2383-2385)cgC>cgA	p.R795R	BCAR1_ENST00000393422.2_Silent_p.R842R|BCAR1_ENST00000542031.2_Silent_p.R822R|BCAR1_ENST00000162330.5_Silent_p.R824R|BCAR1_ENST00000538440.2_Silent_p.R824R|BCAR1_ENST00000535626.2_Silent_p.R676R|BCAR1_ENST00000418647.3_Silent_p.R870R|BCAR1_ENST00000566982.1_5'UTR|BCAR1_ENST00000393420.6_Silent_p.R842R|BCAR1_ENST00000420641.3_Silent_p.R842R			P56945	BCAR1_HUMAN	breast cancer anti-estrogen resistance 1	824	Divergent helix-loop-helix motif.				actin filament organization|B cell receptor signaling pathway|blood coagulation|cell adhesion|cell division|cell migration|cell proliferation|epidermal growth factor receptor signaling pathway|G-protein coupled receptor protein signaling pathway|insulin receptor signaling pathway|integrin-mediated signaling pathway|nerve growth factor receptor signaling pathway|platelet-derived growth factor receptor signaling pathway|positive regulation of cell migration|regulation of apoptosis|regulation of cell growth|T cell receptor signaling pathway	cytosol|focal adhesion|membrane fraction|ruffle	protein kinase binding|protein phosphatase binding|SH3 domain binding|signal transducer activity			breast(2)|central_nervous_system(5)|endometrium(1)|kidney(6)|large_intestine(1)|liver(1)|lung(13)|ovary(1)|prostate(3)|upper_aerodigestive_tract(2)	35				BRCA - Breast invasive adenocarcinoma(221;0.169)		CCACGATGCCGCGCAGGAGGT	0.662000													11	29					6.40141e-05	6.77796e-05	1	1	0
SP6	80320	broad.mit.edu	37	17	45924952	45924952	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-A4IG-01A-11D-A25Y-08	TCGA-BA-A4IG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	200d5ad1-bd1f-4068-a4e4-4b6a3aaaf92d	df122b02-6d09-4441-af8a-cae70fd20fff	g.chr17:45924952G>C	ENST00000536300.1	-	2	1175	c.844C>G	c.(844-846)Cgt>Ggt	p.R282G	SP6_ENST00000342234.2_Missense_Mutation_p.R282G	NM_001258248.1	NP_001245177.1	Q3SY56	SP6_HUMAN	Sp6 transcription factor	282					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)|lung(5)|prostate(1)|skin(1)	8						ACGAAGGGACGGTCGCCGCTG	0.642000													7	34					0	0	1	0	0
PTPN12	5782	broad.mit.edu	37	7	77221564	77221564	+	Missense_Mutation	SNP	A	A	C			TCGA-BA-A4IG-01A-11D-A25Y-08	TCGA-BA-A4IG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	200d5ad1-bd1f-4068-a4e4-4b6a3aaaf92d	df122b02-6d09-4441-af8a-cae70fd20fff	g.chr7:77221564A>C	ENST00000248594.6	+	6	755	c.483A>C	c.(481-483)aaA>aaC	p.K161N	PTPN12_ENST00000435495.2_Missense_Mutation_p.K31N|PTPN12_ENST00000415482.2_Missense_Mutation_p.K42N	NM_002835.3	NP_002826.3	Q05209	PTN12_HUMAN	protein tyrosine phosphatase, non-receptor type 12	161	Tyrosine-protein phosphatase.					soluble fraction	non-membrane spanning protein tyrosine phosphatase activity|SH3 domain binding			breast(2)|cervix(1)|endometrium(2)|kidney(4)|large_intestine(12)|lung(7)|ovary(3)|pancreas(1)|prostate(1)|skin(5)|urinary_tract(1)	39						CACCATTTAAAATTTCTTGTG	0.313000													24	55					0	0	1	0	0
CCDC42	146849	broad.mit.edu	37	17	8633486	8633486	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-A4IG-01A-11D-A25Y-08	TCGA-BA-A4IG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	200d5ad1-bd1f-4068-a4e4-4b6a3aaaf92d	df122b02-6d09-4441-af8a-cae70fd20fff	g.chr17:8633486C>G	ENST00000293845.3	-	7	1139	c.913G>C	c.(913-915)Gag>Cag	p.E305Q	CCDC42_ENST00000539522.2_Missense_Mutation_p.E231Q	NM_144681.2	NP_653282.2	Q96M95	CCD42_HUMAN	coiled-coil domain containing 42	305										kidney(1)|large_intestine(4)|lung(3)|ovary(1)	9						TTTTTCACCTCTGCCCAGATG	0.532000													8	24					0	0	1	0	0
SRRM2	23524	broad.mit.edu	37	16	2808538	2808538	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-A4IG-01A-11D-A25Y-08	TCGA-BA-A4IG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	200d5ad1-bd1f-4068-a4e4-4b6a3aaaf92d	df122b02-6d09-4441-af8a-cae70fd20fff	g.chr16:2808538G>C	ENST00000301740.8	+	5	1132	c.583G>C	c.(583-585)Gat>Cat	p.D195H		NM_016333.3	NP_057417.3	Q9UQ35	SRRM2_HUMAN	serine/arginine repetitive matrix 2	195	Lys-rich.|Ser-rich.			D -> K (in Ref. 6; AAH07752).		Cajal body|catalytic step 2 spliceosome|nuclear speck	C2H2 zinc finger domain binding|protein N-terminus binding|RNA binding			breast(3)|central_nervous_system(1)|cervix(3)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(20)|lung(34)|ovary(6)|pancreas(3)|prostate(2)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(7)	105						aaagaagaaAGATAGAGGACG	0.473000													15	161					0	0	1	0	0
FYB	2533	broad.mit.edu	37	5	39119657	39119657	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-A4IG-01A-11D-A25Y-08	TCGA-BA-A4IG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	200d5ad1-bd1f-4068-a4e4-4b6a3aaaf92d	df122b02-6d09-4441-af8a-cae70fd20fff	g.chr5:39119657C>A	ENST00000351578.6	-	14	2270	c.2080G>T	c.(2080-2082)Gac>Tac	p.D694Y	FYB_ENST00000512982.1_Missense_Mutation_p.D740Y|FYB_ENST00000515010.1_Missense_Mutation_p.D694Y|FYB_ENST00000540520.1_Missense_Mutation_p.D750Y|FYB_ENST00000505428.1_Missense_Mutation_p.D740Y	NM_199335.3	NP_955367.1	O15117	FYB_HUMAN	FYN binding protein	694					cell junction assembly|immune response|intracellular protein kinase cascade|NLS-bearing substrate import into nucleus|protein phosphorylation|T cell receptor signaling pathway	cytosol|nucleus	protein binding			endometrium(2)|kidney(4)|large_intestine(6)|liver(1)|lung(29)|ovary(2)|upper_aerodigestive_tract(1)	45	all_lung(31;0.000343)		Epithelial(62;0.235)			TTCCTGAAGTCTTTTTCTTCT	0.294000													3	4					0.115264	0.117218	1	1	0
TRPA1	8989	broad.mit.edu	37	8	72975102	72975102	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-A4IG-01A-11D-A25Y-08	TCGA-BA-A4IG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	200d5ad1-bd1f-4068-a4e4-4b6a3aaaf92d	df122b02-6d09-4441-af8a-cae70fd20fff	g.chr8:72975102C>A	ENST00000262209.4	-	6	946	c.739G>T	c.(739-741)Gtg>Ttg	p.V247L		NM_007332.2	NP_015628.2	O75762	TRPA1_HUMAN	transient receptor potential cation channel, subfamily A, member 1	247						integral to plasma membrane				NS(1)|breast(2)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(26)|lung(44)|ovary(4)|prostate(6)|stomach(1)	98			Epithelial(68;0.223)		Menthol(DB00825)	CCATTTTGCACAGCCAGGTGG	0.398000													7	76					0.000157383	0.000165667	1	1	0
PPP4R4	57718	broad.mit.edu	37	14	94708174	94708174	+	Missense_Mutation	SNP	A	A	T			TCGA-BA-A4IG-01A-11D-A25Y-08	TCGA-BA-A4IG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	200d5ad1-bd1f-4068-a4e4-4b6a3aaaf92d	df122b02-6d09-4441-af8a-cae70fd20fff	g.chr14:94708174A>T	ENST00000304338.3	+	10	1180	c.1026A>T	c.(1024-1026)aaA>aaT	p.K342N		NM_058237.1	NP_478144.1	Q6NUP7	PP4R4_HUMAN	protein phosphatase 4, regulatory subunit 4	342						cytoplasm|protein serine/threonine phosphatase complex	protein binding			NS(1)|breast(2)|central_nervous_system(1)|kidney(2)|large_intestine(15)|lung(10)|skin(7)|upper_aerodigestive_tract(2)	40						TTTATAAGAAACTTTGTACAT	0.318000													24	86					0	0	1	0	0
C17orf74	201243	broad.mit.edu	37	17	7330242	7330242	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BA-A4IG-01A-11D-A25Y-08	TCGA-BA-A4IG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	200d5ad1-bd1f-4068-a4e4-4b6a3aaaf92d	df122b02-6d09-4441-af8a-cae70fd20fff	g.chr17:7330242G>A	ENST00000333870.3	+	3	1006	c.932G>A	c.(931-933)tGg>tAg	p.W311*	C17orf74_ENST00000574034.1_3'UTR|RP11-104H15.7_ENST00000575310.1_RNA	NM_175734.4	NP_783861.3	Q0P670	CQ074_HUMAN	chromosome 17 open reading frame 74	311						integral to membrane				cervix(1)|endometrium(5)|kidney(1)|large_intestine(3)|lung(6)|ovary(1)|pancreas(1)|prostate(1)|skin(3)	22		Prostate(122;0.157)				TATGACTCCTGGGATCAGCGG	0.706000													8	43					0	0	1	0	0
RAB19	401409	broad.mit.edu	37	7	140110835	140110835	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-A4IG-01A-11D-A25Y-08	TCGA-BA-A4IG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	200d5ad1-bd1f-4068-a4e4-4b6a3aaaf92d	df122b02-6d09-4441-af8a-cae70fd20fff	g.chr7:140110835G>A	ENST00000275874.5	+	3	462	c.264G>A	c.(262-264)atG>atA	p.M88I	RAB19_ENST00000356407.3_Intron|RAB19_ENST00000537763.1_Intron			A4D1S5	RAB19_HUMAN	RAB19, member RAS oncogene family	67					protein transport|small GTPase mediated signal transduction	plasma membrane	GTP binding			breast(3)|large_intestine(2)|lung(3)|upper_aerodigestive_tract(1)	9	Melanoma(164;0.0142)					CTCAAAAGATGAGCCCCCAAA	0.493000													26	117					0	0	1	0	0
PPP4R1	9989	broad.mit.edu	37	18	9550380	9550380	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-A4IG-01A-11D-A25Y-08	TCGA-BA-A4IG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	200d5ad1-bd1f-4068-a4e4-4b6a3aaaf92d	df122b02-6d09-4441-af8a-cae70fd20fff	g.chr18:9550380G>C	ENST00000400556.3	-	17	2381	c.2308C>G	c.(2308-2310)Cta>Gta	p.L770V	PPP4R1_ENST00000400555.3_Missense_Mutation_p.L753V	NM_001042388.2	NP_001035847.1	Q8TF05	PP4R1_HUMAN	protein phosphatase 4, regulatory subunit 1	770					protein phosphorylation|signal transduction	protein phosphatase 4 complex	protein binding|protein phosphatase type 4 regulator activity			large_intestine(1)|skin(2)	3						TATAACTCTAGAAGTAAAATC	0.333000													14	150					0	0	1	0	0
SLC4A5	57835	broad.mit.edu	37	2	74454961	74454961	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-A4IG-01A-11D-A25Y-08	TCGA-BA-A4IG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	200d5ad1-bd1f-4068-a4e4-4b6a3aaaf92d	df122b02-6d09-4441-af8a-cae70fd20fff	g.chr2:74454961G>A	ENST00000423644.1	-	25	3110	c.2713C>T	c.(2713-2715)Cgt>Tgt	p.R905C	SLC4A5_ENST00000483195.1_5'UTR|SLC4A5_ENST00000359484.4_Silent_p.G862G|SLC4A5_ENST00000394019.2_Silent_p.G964G|SLC4A5_ENST00000377632.1_Intron|RP11-287D1.3_ENST00000451608.2_3'UTR|SLC4A5_ENST00000377634.4_Silent_p.G964G|SLC4A5_ENST00000358683.4_Silent_p.G862G|SLC4A5_ENST00000357822.5_Silent_p.G964G|SLC4A5_ENST00000346834.4_Intron			Q9BY07	S4A5_HUMAN	solute carrier family 4 (sodium bicarbonate cotransporter), member 5	0						apical plasma membrane|integral to membrane	inorganic anion exchanger activity|sodium:bicarbonate symporter activity	p.G964G(1)		breast(5)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(12)|lung(13)|ovary(5)|pancreas(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	48						GGGAGGCCACGCCCATGTAGA	0.577000													3	14					0	0	1	0	0
ANO3	63982	broad.mit.edu	37	11	26681950	26681950	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-A4IG-01A-11D-A25Y-08	TCGA-BA-A4IG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	200d5ad1-bd1f-4068-a4e4-4b6a3aaaf92d	df122b02-6d09-4441-af8a-cae70fd20fff	g.chr11:26681950C>T	ENST00000256737.3	+	27	3757	c.2905C>T	c.(2905-2907)Cgg>Tgg	p.R969W	ANO3_ENST00000531568.1_Missense_Mutation_p.R823W|ANO3_ENST00000537978.1_Missense_Mutation_p.R953W|ANO3_ENST00000525139.1_Missense_Mutation_p.R953W	NM_031418.2	NP_113606.2	Q9BYT9	ANO3_HUMAN	anoctamin 3	969						chloride channel complex	chloride channel activity			breast(2)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(33)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	68						GCAACAACAACGGAGAAAAAG	0.428000													19	61					0	0	1	0	0
TICAM1	148022	broad.mit.edu	37	19	4817854	4817854	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-A4IG-01A-11D-A25Y-08	TCGA-BA-A4IG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	200d5ad1-bd1f-4068-a4e4-4b6a3aaaf92d	df122b02-6d09-4441-af8a-cae70fd20fff	g.chr19:4817854G>C	ENST00000248244.5	-	2	765	c.536C>G	c.(535-537)cCa>cGa	p.P179R		NM_182919.3	NP_891549.1	Q8IUC6	TCAM1_HUMAN	toll-like receptor adaptor molecule 1	179					apoptosis|I-kappaB kinase/NF-kappaB cascade|inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|endosome membrane|plasma membrane	protein kinase binding|signal transducer activity			NS(2)|breast(2)|endometrium(2)|kidney(2)|large_intestine(4)|lung(6)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	26				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0139)		AATGGGGCGTGGGAGGCTCCT	0.642000													19	131					0	0	1	0	0
IGLV2-28	28812	broad.mit.edu	37	22	23006961	23006961	+	RNA	SNP	C	C	T			TCGA-BA-A4IG-01A-11D-A25Y-08	TCGA-BA-A4IG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	200d5ad1-bd1f-4068-a4e4-4b6a3aaaf92d	df122b02-6d09-4441-af8a-cae70fd20fff	g.chr22:23006961C>T	ENST00000385099.1	+	0	64																											GGCTCTGCTCCTCCTCACCCT	0.627000													6	14					0	0	1	0	0
CYP4F8	11283	broad.mit.edu	37	19	15728889	15728889	+	RNA	SNP	G	G	A			TCGA-BA-A4IG-01A-11D-A25Y-08	TCGA-BA-A4IG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	200d5ad1-bd1f-4068-a4e4-4b6a3aaaf92d	df122b02-6d09-4441-af8a-cae70fd20fff	g.chr19:15728889G>A	ENST00000441682.2	+	0	341							P98187	CP4F8_HUMAN	cytochrome P450, family 4, subfamily F, polypeptide 8						prostaglandin metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	alkane 1-monooxygenase activity|aromatase activity|electron carrier activity|heme binding|oxygen binding|protein binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(14)|skin(1)	26						GAGGTGGTTGGGCCCCATCAC	0.597000													25	64					0	0	1	0	0
ZNF233	353355	broad.mit.edu	37	19	44778518	44778518	+	Missense_Mutation	SNP	T	T	C			TCGA-BA-A4IG-01A-11D-A25Y-08	TCGA-BA-A4IG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	200d5ad1-bd1f-4068-a4e4-4b6a3aaaf92d	df122b02-6d09-4441-af8a-cae70fd20fff	g.chr19:44778518T>C	ENST00000391958.2	+	5	1832	c.1705T>C	c.(1705-1707)Tgt>Cgt	p.C569R	ZNF233_ENST00000592581.1_3'UTR|ZNF233_ENST00000334152.1_Missense_Mutation_p.C551R|ZNF235_ENST00000589799.1_Intron	NM_181756.2	NP_861421.2	A6NK53	ZN233_HUMAN	zinc finger protein 233	569					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(4)|skin(3)|urinary_tract(1)	20		Prostate(69;0.0435)|all_neural(266;0.226)				ATGTGATGTGTGTGGGAAAGG	0.448000													6	100					0	0	1	0	0
NFATC3	4775	broad.mit.edu	37	16	68156551	68156551	+	Silent	SNP	G	G	T			TCGA-BA-A4IG-01A-11D-A25Y-08	TCGA-BA-A4IG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	200d5ad1-bd1f-4068-a4e4-4b6a3aaaf92d	df122b02-6d09-4441-af8a-cae70fd20fff	g.chr16:68156551G>T	ENST00000349223.5	+	2	989	c.765G>T	c.(763-765)ctG>ctT	p.L255L	NFATC3_ENST00000575270.1_Silent_p.L255L|NFATC3_ENST00000535127.2_3'UTR|NFATC3_ENST00000346183.3_Silent_p.L255L|NFATC3_ENST00000329524.4_Silent_p.L255L	NM_173163.2	NP_775186.1	Q12968	NFAC3_HUMAN	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3	255	3 X SP repeats.				inflammatory response|transcription from RNA polymerase II promoter	nucleolus|plasma membrane	DNA binding			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(7)|liver(1)|lung(19)|pancreas(1)|skin(3)|upper_aerodigestive_tract(2)	44		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0119)|Epithelial(162;0.0452)|all cancers(182;0.24)		AGAATTGGCTGAGCCCCAGGC	0.532000													8	111					5.4927e-09	6.14091e-09	1	1	0
MYH10	4628	broad.mit.edu	37	17	8383508	8383508	+	Silent	SNP	G	G	T			TCGA-BA-A4IG-01A-11D-A25Y-08	TCGA-BA-A4IG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	200d5ad1-bd1f-4068-a4e4-4b6a3aaaf92d	df122b02-6d09-4441-af8a-cae70fd20fff	g.chr17:8383508G>T	ENST00000360416.3	-	40	5655	c.5517C>A	c.(5515-5517)gtC>gtA	p.V1839V	MYH10_ENST00000396239.1_Silent_p.V1829V|MYH10_ENST00000379980.4_Silent_p.V1824V|MYH10_ENST00000269243.4_Silent_p.V1808V|NDEL1_ENST00000299734.7_Intron	NM_001256012.1	NP_001242941.1	P35580	MYH10_HUMAN	myosin, heavy chain 10, non-muscle	1808					actin filament-based movement|axon guidance|cytokinesis after mitosis|regulation of cell shape	cell cortex|cleavage furrow|midbody|myosin complex|stress fiber	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity			breast(5)|endometrium(9)|kidney(2)|large_intestine(16)|lung(9)|ovary(3)|prostate(3)|skin(4)|stomach(1)	52						ACTTAGACTTGACAGCACCCT	0.587000													12	63					1.61879e-10	1.82114e-10	1	1	0
TXLNGY	246126	broad.mit.edu	37	Y	21761644	21761644	+	RNA	SNP	A	A	T			TCGA-BA-A4IG-01A-11D-A25Y-08	TCGA-BA-A4IG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	200d5ad1-bd1f-4068-a4e4-4b6a3aaaf92d	df122b02-6d09-4441-af8a-cae70fd20fff	g.chrY:21761644A>T	ENST00000253320.4	+	0	4652							Q9BZA5	CY15A_HUMAN												haematopoietic_and_lymphoid_tissue(1)	1						TATATGGATAAGTTTGAAGAA	0.274000													6	5					0	0	1	0	0
RHOBTB2	23221	broad.mit.edu	37	8	22863632	22863632	+	Silent	SNP	C	C	T			TCGA-BA-A4IG-01A-11D-A25Y-08	TCGA-BA-A4IG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	200d5ad1-bd1f-4068-a4e4-4b6a3aaaf92d	df122b02-6d09-4441-af8a-cae70fd20fff	g.chr8:22863632C>T	ENST00000251822.6	+	4	993	c.456C>T	c.(454-456)gtC>gtT	p.V152V	RP11-875O11.1_ENST00000523884.1_RNA|RHOBTB2_ENST00000519685.1_Silent_p.V174V|RHOBTB2_ENST00000523918.1_3'UTR|RHOBTB2_ENST00000522948.1_Silent_p.V159V	NM_015178.2	NP_055993.2	Q9BYZ6	RHBT2_HUMAN	Rho-related BTB domain containing 2	152	Rho-like.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|plasma membrane	GTP binding			breast(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(6)|lung(11)|ovary(2)|prostate(2)|skin(1)|urinary_tract(1)	31		Prostate(55;0.0513)|Breast(100;0.214)		Colorectal(74;0.0157)|COAD - Colon adenocarcinoma(73;0.064)		TGGAGGCTGTCAACAGGGCTA	0.607000													21	222					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179413855	179413855	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-A4IG-01A-11D-A25Y-08	TCGA-BA-A4IG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	200d5ad1-bd1f-4068-a4e4-4b6a3aaaf92d	df122b02-6d09-4441-af8a-cae70fd20fff	g.chr2:179413855G>A	ENST00000589042.1	-	339	92722	c.92498C>T	c.(92497-92499)aCa>aTa	p.T30833I	TTN-AS1_ENST00000591332.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN-AS1_ENST00000586707.1_RNA|TTN-AS1_ENST00000586452.1_RNA|RP11-65L3.2_ENST00000603415.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.T21768I|TTN-AS1_ENST00000456053.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.T21893I|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000438095.1_RNA|TTN-AS1_ENST00000592600.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.T28265I|TTN_ENST00000591111.1_Missense_Mutation_p.T29192I|TTN-AS1_ENST00000590932.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.T21960I|TTN-AS1_ENST00000586831.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	29192	Fibronectin type-III 124.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TGTCTTTGATGTGTCTGTTAC	0.458000													33	93					0	0	1	0	0
HIRA	7290	broad.mit.edu	37	22	19363199	19363199	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-A4IG-01A-11D-A25Y-08	TCGA-BA-A4IG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	200d5ad1-bd1f-4068-a4e4-4b6a3aaaf92d	df122b02-6d09-4441-af8a-cae70fd20fff	g.chr22:19363199G>A	ENST00000263208.5	-	15	1986	c.1730C>T	c.(1729-1731)cCa>cTa	p.P577L	HIRA_ENST00000546308.1_Missense_Mutation_p.P533L|HIRA_ENST00000340170.4_Missense_Mutation_p.P577L|HIRA_ENST00000541063.1_Missense_Mutation_p.P533L	NM_003325.3	NP_003316.3	P54198	HIRA_HUMAN	histone cell cycle regulator	577	Interaction with CCNA1.				chromatin modification|regulation of transcription from RNA polymerase II promoter	PML body	chromatin binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(14)|ovary(2)|prostate(1)|skin(1)	37	Colorectal(54;0.0993)					AGGAGCACCTGGTGTGGCTTT	0.577000													9	69					0	0	1	0	0
TMPRSS11B	132724	broad.mit.edu	37	4	69096989	69096989	+	Silent	SNP	G	G	A			TCGA-BA-A4IG-01A-11D-A25Y-08	TCGA-BA-A4IG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	200d5ad1-bd1f-4068-a4e4-4b6a3aaaf92d	df122b02-6d09-4441-af8a-cae70fd20fff	g.chr4:69096989G>A	ENST00000332644.5	-	7	779	c.618C>T	c.(616-618)ggC>ggT	p.G206G		NM_182502.3	NP_872308.2	Q86T26	TM11B_HUMAN	transmembrane protease, serine 11B	206	Peptidase S1.				proteolysis	extracellular region|integral to plasma membrane	serine-type endopeptidase activity			breast(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(14)|ovary(1)|skin(1)	27						AGTAGTGACGGCCTTTCCATT	0.473000													9	53					0	0	1	0	0
TP63	8626	broad.mit.edu	37	3	189611999	189611999	+	Missense_Mutation	SNP	T	T	G			TCGA-BA-A4IG-01A-11D-A25Y-08	TCGA-BA-A4IG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	200d5ad1-bd1f-4068-a4e4-4b6a3aaaf92d	df122b02-6d09-4441-af8a-cae70fd20fff	g.chr3:189611999T>G	ENST00000264731.3	+	14	1840	c.1751T>G	c.(1750-1752)cTg>cGg	p.L584R	TP63_ENST00000392461.3_Silent_p.S410S|TP63_ENST00000320472.5_Silent_p.S504S|TP63_ENST00000392460.3_Missense_Mutation_p.W553G|TP63_ENST00000440651.2_Missense_Mutation_p.L580R|TP63_ENST00000354600.5_Missense_Mutation_p.L490R|TP63_ENST00000449992.1_Missense_Mutation_p.L405R|TP63_ENST00000382063.4_Missense_Mutation_p.L499R|TP63_ENST00000392463.2_Missense_Mutation_p.W459G|TP63_ENST00000456148.1_Missense_Mutation_p.L486R	NM_001114978.1|NM_003722.4	NP_001108450.1|NP_003713.3	Q9H3D4	P63_HUMAN	tumor protein p63	584	SAM.				anti-apoptosis|cellular response to UV|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|mitotic cell cycle G1/S transition DNA damage checkpoint|negative regulation of transcription from RNA polymerase II promoter|Notch signaling pathway|positive regulation of Notch signaling pathway|protein homotetramerization|regulation of neuron apoptosis|response to gamma radiation|response to X-ray	chromatin|cytosol|dendrite|Golgi apparatus|transcription factor complex	chromatin binding|damaged DNA binding|double-stranded DNA binding|identical protein binding|metal ion binding|p53 binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(7)|kidney(5)|large_intestine(12)|lung(15)|ovary(2)|skin(9)|upper_aerodigestive_tract(6)	61	all_cancers(143;3.35e-10)|Ovarian(172;0.0925)		Lung(62;3.33e-05)	GBM - Glioblastoma multiforme(93;0.0227)		GCACAGGATCTGGCAAGTCTG	0.502000										HNSCC(45;0.13)			10	81					0	0	1	0	0
ZNF558	148156	broad.mit.edu	37	19	8922717	8922717	+	Missense_Mutation	SNP	T	T	A			TCGA-BA-A4IG-01A-11D-A25Y-08	TCGA-BA-A4IG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	200d5ad1-bd1f-4068-a4e4-4b6a3aaaf92d	df122b02-6d09-4441-af8a-cae70fd20fff	g.chr19:8922717T>A	ENST00000601372.1	-	10	1160	c.449A>T	c.(448-450)aAa>aTa	p.K150I	ZNF558_ENST00000301475.1_Missense_Mutation_p.K150I|ZNF558_ENST00000444186.2_Missense_Mutation_p.K79I			Q96NG5	ZN558_HUMAN	zinc finger protein 558	150					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			central_nervous_system(1)|endometrium(2)|large_intestine(3)|lung(7)|prostate(1)|skin(1)	15						TTCATTGAGTTTCACTCCACG	0.338000													17	39					0	0	1	0	0
ERGIC2	51290	broad.mit.edu	37	12	29514592	29514592	+	Silent	SNP	C	C	T			TCGA-BA-A4IG-01A-11D-A25Y-08	TCGA-BA-A4IG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	200d5ad1-bd1f-4068-a4e4-4b6a3aaaf92d	df122b02-6d09-4441-af8a-cae70fd20fff	g.chr12:29514592C>T	ENST00000360150.4	-	6	435	c.360G>A	c.(358-360)caG>caA	p.Q120Q		NM_016570.2	NP_057654.2	Q96RQ1	ERGI2_HUMAN	ERGIC and golgi 2	120					vesicle-mediated transport	endoplasmic reticulum membrane|ER-Golgi intermediate compartment membrane|Golgi apparatus|integral to membrane|nucleus				endometrium(2)|kidney(1)|large_intestine(1)|lung(2)|ovary(1)|prostate(2)|urinary_tract(1)	10	Lung NSC(12;2.02e-08)|Acute lymphoblastic leukemia(23;0.00885)|all_hematologic(23;0.0155)|Lung SC(9;0.184)				Arsenic trioxide(DB01169)	GCCACTCTTTCTGCTGTGGTG	0.289000													30	87					0	0	1	0	0
HS6ST1	9394	broad.mit.edu	37	2	129026418	129026418	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-A4IG-01A-11D-A25Y-08	TCGA-BA-A4IG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	200d5ad1-bd1f-4068-a4e4-4b6a3aaaf92d	df122b02-6d09-4441-af8a-cae70fd20fff	g.chr2:129026418C>T	ENST00000259241.6	-	2	567	c.554G>A	c.(553-555)cGa>cAa	p.R185Q		NM_004807.2	NP_004798.3	O60243	H6ST1_HUMAN	heparan sulfate 6-O-sulfotransferase 1	185	3'-phosphate binding (Potential).				heparan sulfate proteoglycan biosynthetic process, enzymatic modification	integral to plasma membrane	sulfotransferase activity			endometrium(3)|liver(1)|lung(7)|pancreas(1)|prostate(2)|skin(1)	15	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.117)		CACGGGGTCTCGTAGCAGGGT	0.627000													10	38					0	0	1	0	0
TMCO3	55002	broad.mit.edu	37	13	114150217	114150217	+	Silent	SNP	A	A	G			TCGA-BA-A4IG-01A-11D-A25Y-08	TCGA-BA-A4IG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	200d5ad1-bd1f-4068-a4e4-4b6a3aaaf92d	df122b02-6d09-4441-af8a-cae70fd20fff	g.chr13:114150217A>G	ENST00000434316.2	+	2	680	c.321A>G	c.(319-321)gaA>gaG	p.E107E	TMCO3_ENST00000375391.1_Silent_p.E107E|TMCO3_ENST00000474393.1_3'UTR	NM_017905.4	NP_060375.4	Q6UWJ1	TMCO3_HUMAN	transmembrane and coiled-coil domains 3	107						integral to membrane	solute:hydrogen antiporter activity			NS(1)|endometrium(4)|large_intestine(9)|liver(1)|lung(8)|prostate(1)|stomach(1)	25	Lung NSC(43;0.0161)|all_neural(89;0.0337)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.0145)|all_epithelial(44;0.00286)|all_lung(25;0.0273)|Breast(118;0.0411)|Lung NSC(25;0.0983)	all cancers(43;0.0317)			ATGAAAGTGAAAATTCCGTTT	0.502000													17	20					0	0	1	0	0
TGS1	96764	broad.mit.edu	37	8	56708566	56708566	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-A4IG-01A-11D-A25Y-08	TCGA-BA-A4IG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	200d5ad1-bd1f-4068-a4e4-4b6a3aaaf92d	df122b02-6d09-4441-af8a-cae70fd20fff	g.chr8:56708566G>C	ENST00000260129.5	+	7	1874	c.1397G>C	c.(1396-1398)cGg>cCg	p.R466P		NM_024831.6	NP_079107.6	Q96RS0	TGS1_HUMAN	trimethylguanosine synthase 1	466					cellular lipid metabolic process|ncRNA metabolic process|regulation of transcription, DNA-dependent|RNA capping|spliceosomal snRNP assembly|transcription, DNA-dependent	Cajal body|cytosol	RNA trimethylguanosine synthase activity			breast(3)|central_nervous_system(1)|endometrium(4)|large_intestine(5)|lung(10)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	29		all_lung(136;0.119)|all_epithelial(80;0.125)|Lung NSC(129;0.147)	Epithelial(17;0.00027)|all cancers(17;0.00251)			TTCAGTCATCGGCAGGTCAGG	0.343000													21	67					0	0	1	0	0
OTUD6B	51633	broad.mit.edu	37	8	92083370	92083370	+	Missense_Mutation	SNP	A	A	T			TCGA-BA-A4IG-01A-11D-A25Y-08	TCGA-BA-A4IG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	200d5ad1-bd1f-4068-a4e4-4b6a3aaaf92d	df122b02-6d09-4441-af8a-cae70fd20fff	g.chr8:92083370A>T	ENST00000285420.4	+	2	276	c.177A>T	c.(175-177)aaA>aaT	p.K59N	OTUD6B_ENST00000404789.3_5'UTR	NM_016023.3	NP_057107.3	Q8N6M0	OTU6B_HUMAN	OTU domain containing 6B	29										endometrium(1)|kidney(1)|large_intestine(3)|lung(4)|ovary(2)	11			BRCA - Breast invasive adenocarcinoma(11;0.0187)			TTTCAGCCAAAATTCAGGGCA	0.438000													17	82					0	0	1	0	0
RASIP1	54922	broad.mit.edu	37	19	49225236	49225236	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-A4IG-01A-11D-A25Y-08	TCGA-BA-A4IG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	200d5ad1-bd1f-4068-a4e4-4b6a3aaaf92d	df122b02-6d09-4441-af8a-cae70fd20fff	g.chr19:49225236G>A	ENST00000222145.4	-	11	2771	c.2567C>T	c.(2566-2568)aCc>aTc	p.T856I		NM_017805.2	NP_060275.2	Q5U651	RAIN_HUMAN	Ras interacting protein 1	856	Dilute.				signal transduction	Golgi stack|perinuclear region of cytoplasm				central_nervous_system(1)|endometrium(2)|large_intestine(5)|lung(7)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	21		all_lung(116;4.89e-06)|all_epithelial(76;7.04e-06)|Lung NSC(112;9.34e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;9.98e-05)|all cancers(93;0.000272)|Epithelial(262;0.0155)|GBM - Glioblastoma multiforme(486;0.0222)		GGGGTGGTCGGTTCTTAGGCT	0.622000													19	48					0	0	1	0	0
LPHN2	23266	broad.mit.edu	37	1	82433849	82433849	+	Missense_Mutation	SNP	A	A	C			TCGA-BA-A4IG-01A-11D-A25Y-08	TCGA-BA-A4IG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	200d5ad1-bd1f-4068-a4e4-4b6a3aaaf92d	df122b02-6d09-4441-af8a-cae70fd20fff	g.chr1:82433849A>C	ENST00000370728.1	+	16	3122	c.2477A>C	c.(2476-2478)aAt>aCt	p.N826T	LPHN2_ENST00000319517.6_Missense_Mutation_p.N813T|LPHN2_ENST00000335786.5_Missense_Mutation_p.N826T|LPHN2_ENST00000370727.1_Missense_Mutation_p.N826T|LPHN2_ENST00000271029.4_Missense_Mutation_p.N826T|LPHN2_ENST00000370721.1_Missense_Mutation_p.N751T|LPHN2_ENST00000370713.1_Missense_Mutation_p.N813T|LPHN2_ENST00000469377.2_Intron|LPHN2_ENST00000370723.1_Missense_Mutation_p.N813T|LPHN2_ENST00000370715.1_Missense_Mutation_p.N813T|LPHN2_ENST00000370725.1_Missense_Mutation_p.N826T|LPHN2_ENST00000370717.2_Missense_Mutation_p.N826T|LPHN2_ENST00000359929.3_Missense_Mutation_p.N813T|LPHN2_ENST00000394879.1_Missense_Mutation_p.N813T|LPHN2_ENST00000370730.1_Missense_Mutation_p.N826T			O95490	LPHN2_HUMAN	latrophilin 2	826	GPS.				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|latrotoxin receptor activity|sugar binding	p.N813S(1)|p.N826S(1)		NS(3)|breast(6)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(18)|liver(2)|lung(37)|ovary(3)|pancreas(1)|prostate(3)|skin(22)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	119				all cancers(265;0.00142)|Epithelial(280;0.00829)|OV - Ovarian serous cystadenocarcinoma(397;0.077)|STAD - Stomach adenocarcinoma(256;0.248)		CACCTAACCAATTTTGCAATT	0.413000													37	70					0	0	1	0	0
ZNF600	162966	broad.mit.edu	37	19	53270816	53270816	+	Nonsense_Mutation	SNP	T	T	A			TCGA-BA-A4IG-01A-11D-A25Y-08	TCGA-BA-A4IG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	200d5ad1-bd1f-4068-a4e4-4b6a3aaaf92d	df122b02-6d09-4441-af8a-cae70fd20fff	g.chr19:53270816T>A	ENST00000338230.3	-	3	460	c.193A>T	c.(193-195)Aag>Tag	p.K65*		NM_198457.2	NP_940859.2	Q6ZNG1	ZN600_HUMAN	zinc finger protein 600	65					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(2)|kidney(4)|large_intestine(9)|liver(1)|lung(10)|prostate(1)|upper_aerodigestive_tract(1)	30				OV - Ovarian serous cystadenocarcinoma(262;0.0241)|GBM - Glioblastoma multiforme(134;0.0404)		CCAGTCAACTTTTTTATTTTT	0.378000													106	233					0	0	1	0	0
RSRC1	51319	broad.mit.edu	37	3	157841746	157841746	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-A4IG-01A-11D-A25Y-08	TCGA-BA-A4IG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	200d5ad1-bd1f-4068-a4e4-4b6a3aaaf92d	df122b02-6d09-4441-af8a-cae70fd20fff	g.chr3:157841746G>T	ENST00000464171.1	+	3	411	c.286G>T	c.(286-288)Gtt>Ttt	p.V96F	RSRC1_ENST00000295930.3_Missense_Mutation_p.V96F|RSRC1_ENST00000312179.6_Missense_Mutation_p.V96F|RSRC1_ENST00000480820.1_Missense_Mutation_p.V96F|RSRC1_ENST00000475278.2_Missense_Mutation_p.V96F	NM_001271834.1	NP_001258763.1	Q96IZ7	RSRC1_HUMAN	arginine/serine-rich coiled-coil 1	96	Arg/Ser-rich.				nucleocytoplasmic transport	cytoplasm|nuclear speck	protein binding			cervix(1)|endometrium(2)|large_intestine(3)|lung(11)|upper_aerodigestive_tract(1)	18			Lung(72;0.00416)|LUSC - Lung squamous cell carcinoma(72;0.00575)			ATCCTATAGAGTTCAGAGGTC	0.408000													12	90					1.08611e-07	1.19938e-07	1	1	0
FAM65B	9750	broad.mit.edu	37	6	24848286	24848286	+	Silent	SNP	C	C	T			TCGA-BA-A4IG-01A-11D-A25Y-08	TCGA-BA-A4IG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	200d5ad1-bd1f-4068-a4e4-4b6a3aaaf92d	df122b02-6d09-4441-af8a-cae70fd20fff	g.chr6:24848286C>T	ENST00000259698.4	-	12	1219	c.1044G>A	c.(1042-1044)ccG>ccA	p.P348P	FAM65B_ENST00000540914.1_Silent_p.P348P|FAM65B_ENST00000538035.1_Silent_p.P377P|FAM65B_ENST00000510784.2_Silent_p.P382P|FAM65B_ENST00000378023.4_Silent_p.P348P	NM_014722.2	NP_055537.2	Q9Y4F9	FA65B_HUMAN	family with sequence similarity 65, member B	348					cell differentiation|muscle organ development	cytoskeleton|filopodium|mitochondrion	binding			breast(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(10)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	25						TGGGCGTTTCCGGGGTACCCT	0.532000													5	40					0	0	1	0	0
KIF5C	3800	broad.mit.edu	37	2	149806902	149806902	+	Silent	SNP	C	C	A			TCGA-BA-A4IG-01A-11D-A25Y-08	TCGA-BA-A4IG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	200d5ad1-bd1f-4068-a4e4-4b6a3aaaf92d	df122b02-6d09-4441-af8a-cae70fd20fff	g.chr2:149806902C>A	ENST00000435030.1	+	10	1262	c.894C>A	c.(892-894)acC>acA	p.T298T	KIF5C_ENST00000397413.1_Silent_p.T66T|KIF5C_ENST00000464066.1_3'UTR|KIF5C_ENST00000414838.2_Silent_p.T203T			O60282	KIF5C_HUMAN	kinesin family member 5C	298	Kinesin-motor.|Microtubule-binding.				microtubule-based movement|organelle organization	cytoplasm|kinesin complex|microtubule	ATP binding|microtubule motor activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(13)|lung(12)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	36				BRCA - Breast invasive adenocarcinoma(221;0.108)		ACTGCAGAACCACCATCGTCA	0.478000													8	48					5.18039e-06	5.58366e-06	1	1	0
DOK6	220164	broad.mit.edu	37	18	67406319	67406319	+	Nonsense_Mutation	SNP	G	G	T			TCGA-BA-A4IG-01A-11D-A25Y-08	TCGA-BA-A4IG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	200d5ad1-bd1f-4068-a4e4-4b6a3aaaf92d	df122b02-6d09-4441-af8a-cae70fd20fff	g.chr18:67406319G>T	ENST00000382713.5	+	6	908	c.718G>T	c.(718-720)Gaa>Taa	p.E240*		NM_152721.5	NP_689934.2	Q6PKX4	DOK6_HUMAN	docking protein 6	240							insulin receptor binding			central_nervous_system(1)|cervix(1)|endometrium(1)|large_intestine(6)|lung(6)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	20		Colorectal(73;0.083)|Esophageal squamous(42;0.131)				ATTAATGCTAGAAATGGAACA	0.453000													41	94					8.69298e-16	9.90339e-16	1	1	0
ALK	238	broad.mit.edu	37	2	29940550	29940550	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-A4IG-01A-11D-A25Y-08	TCGA-BA-A4IG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	200d5ad1-bd1f-4068-a4e4-4b6a3aaaf92d	df122b02-6d09-4441-af8a-cae70fd20fff	g.chr2:29940550C>G	ENST00000389048.3	-	2	1587	c.681G>C	c.(679-681)ttG>ttC	p.L227F	ALK_ENST00000431873.1_Missense_Mutation_p.L227F	NM_004304.4	NP_004295.2	Q9UM73	ALK_HUMAN	anaplastic lymphoma receptor tyrosine kinase	227					protein autophosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity		ATIC/ALK(24)|FN1/ALK(2)|C2orf44/ALK(2)|TPM3/ALK(33)|KLC1/ALK(2)|VCL/ALK(4)|TPM4/ALK(12)|KIF5B/ALK(8)|RANBP2/ALK(34)|SQSTM1/ALK(2)|EML4/ALK(543)|PPFIBP1/ALK(3)|SEC31A/ALK(3)|NPM1/ALK(632)|CLTC/ALK(44)|CARS/ALK(5)|MSN/ALK(6)|TFG/ALK(9)	NS(2)|autonomic_ganglia(198)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(7)|kidney(4)|large_intestine(25)|lung(61)|ovary(6)|pancreas(1)|prostate(2)|skin(5)|soft_tissue(3)|stomach(2)|thyroid(2)	340	Acute lymphoblastic leukemia(172;0.155)				Adenosine triphosphate(DB00171)	TTGGTGATTCCAAGGAGCTAT	0.408000			"""T, Mis, A"""	"""NPM1, TPM3, TFG, TPM4, ATIC, CLTC, MSN, ALO17, CARS, EML4, KIF5B, C2orf22"""	"""ALCL, NSCLC, Neuroblastoma"""	neuroblastoma			Neuroblastoma, Familial Clustering of;Congenital Central Hypoventilation Syndrome				11	100					0	0	1	0	0
ZNF679	168417	broad.mit.edu	37	7	63720710	63720710	+	Missense_Mutation	SNP	A	A	G			TCGA-BA-A4IG-01A-11D-A25Y-08	TCGA-BA-A4IG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	200d5ad1-bd1f-4068-a4e4-4b6a3aaaf92d	df122b02-6d09-4441-af8a-cae70fd20fff	g.chr7:63720710A>G	ENST00000421025.1	+	3	420	c.151A>G	c.(151-153)Aac>Gac	p.N51D	ZNF679_ENST00000255746.4_Missense_Mutation_p.N51D	NM_001159524.1|NM_153363.2	NP_001152996.1|NP_699194.2	Q8IYX0	ZN679_HUMAN	zinc finger protein 679	51	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(2)|kidney(3)|lung(11)|skin(1)|stomach(1)	18						GAACTACAGAAACCTGGTCTC	0.373000													35	122					0	0	1	0	0
RIMS4	140730	broad.mit.edu	37	20	43386398	43386398	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-A4IG-01A-11D-A25Y-08	TCGA-BA-A4IG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	200d5ad1-bd1f-4068-a4e4-4b6a3aaaf92d	df122b02-6d09-4441-af8a-cae70fd20fff	g.chr20:43386398C>G	ENST00000372851.3	-	4	430	c.364G>C	c.(364-366)Ggt>Cgt	p.G122R	RIMS4_ENST00000541604.2_Missense_Mutation_p.G123R	NM_001205317.1|NM_182970.3	NP_001192246.1|NP_892015.1	Q9H426	RIMS4_HUMAN	regulating synaptic membrane exocytosis 4	122	C2.				exocytosis|neurotransmitter transport	cell junction|synapse				central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(11)|ovary(5)|urinary_tract(1)	29		Myeloproliferative disorder(115;0.0122)				TCCTGCAGACCGATCTCCACA	0.562000													5	75					0	0	1	0	0
LRRTM1	347730	broad.mit.edu	37	2	80530545	80530545	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-A4IG-01A-11D-A25Y-08	TCGA-BA-A4IG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	200d5ad1-bd1f-4068-a4e4-4b6a3aaaf92d	df122b02-6d09-4441-af8a-cae70fd20fff	g.chr2:80530545G>C	ENST00000295057.3	-	2	1056	c.400C>G	c.(400-402)Cgg>Ggg	p.R134G	CTNNA2_ENST00000361291.4_Intron|CTNNA2_ENST00000541047.1_Intron|CTNNA2_ENST00000466387.1_Intron|CTNNA2_ENST00000496558.1_Intron|CTNNA2_ENST00000540488.1_Intron|LRRTM1_ENST00000409148.1_Missense_Mutation_p.R134G|CTNNA2_ENST00000402739.4_Intron	NM_178839.4	NP_849161.2	Q86UE6	LRRT1_HUMAN	leucine rich repeat transmembrane neuronal 1	134						axon|endoplasmic reticulum membrane|growth cone|integral to membrane				NS(1)|breast(1)|endometrium(5)|large_intestine(7)|liver(1)|lung(33)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(5)|urinary_tract(2)	63						GGCATGGGCCGGAAGGTGGTG	0.627000										HNSCC(69;0.2)			8	88					0	0	1	0	0
PARPBP	55010	broad.mit.edu	37	12	102559554	102559554	+	Silent	SNP	T	T	C			TCGA-BA-A4IG-01A-11D-A25Y-08	TCGA-BA-A4IG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	200d5ad1-bd1f-4068-a4e4-4b6a3aaaf92d	df122b02-6d09-4441-af8a-cae70fd20fff	g.chr12:102559554T>C	ENST00000327680.2	+	7	934	c.471T>C	c.(469-471)taT>taC	p.Y157Y	PARPBP_ENST00000541394.1_Silent_p.Y315Y|PARPBP_ENST00000543784.1_Silent_p.Y124Y|PARPBP_ENST00000535811.1_Intron|PARPBP_ENST00000392911.2_Silent_p.Y157Y|PARPBP_ENST00000378128.3_Silent_p.Y238Y|PARPBP_ENST00000358383.5_Silent_p.Y238Y	NM_017915.3	NP_060385.3	Q9NWS1	PR1BP_HUMAN	PARP1 binding protein	238					response to DNA damage stimulus	cytoplasm|nucleus	DNA binding			endometrium(1)|lung(8)|urinary_tract(2)	11						GGAAAGGATATGCACCACCAC	0.338000													8	130					0	0	1	0	0
PBX4	80714	broad.mit.edu	37	19	19675809	19675809	+	Silent	SNP	C	C	T			TCGA-BA-A4IG-01A-11D-A25Y-08	TCGA-BA-A4IG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	200d5ad1-bd1f-4068-a4e4-4b6a3aaaf92d	df122b02-6d09-4441-af8a-cae70fd20fff	g.chr19:19675809C>T	ENST00000251203.8	-	6	1144	c.858G>A	c.(856-858)acG>acA	p.T286T		NM_025245.2	NP_079521.1	Q9BYU1	PBX4_HUMAN	pre-B-cell leukemia homeobox 4	286							sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			large_intestine(1)|lung(4)|ovary(1)|prostate(3)	9						TATCCACAGCCGTTTTACCCG	0.527000													22	263					0	0	1	0	0
JAK1	3716	broad.mit.edu	37	1	65304245	65304245	+	Missense_Mutation	SNP	T	T	G			TCGA-BA-A4IG-01A-11D-A25Y-08	TCGA-BA-A4IG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	200d5ad1-bd1f-4068-a4e4-4b6a3aaaf92d	df122b02-6d09-4441-af8a-cae70fd20fff	g.chr1:65304245T>G	ENST00000342505.4	-	21	3118	c.2870A>C	c.(2869-2871)gAa>gCa	p.E957A		NM_002227.2	NP_002218.2	P23458	JAK1_HUMAN	Janus kinase 1	957	Protein kinase 2.				interferon-gamma-mediated signaling pathway|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|response to antibiotic|type I interferon-mediated signaling pathway	cytoskeleton|cytosol|endomembrane system|membrane|nucleus	ATP binding|growth hormone receptor binding|non-membrane spanning protein tyrosine kinase activity			breast(5)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(48)|kidney(3)|large_intestine(8)|liver(2)|lung(19)|ovary(1)|prostate(12)|skin(1)|soft_tissue(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	120				BRCA - Breast invasive adenocarcinoma(111;0.0485)		AGGCAGAAATTCCATGATGAG	0.413000			Mis		ALL								18	51					0	0	1	0	0
ARMC5	79798	broad.mit.edu	37	16	31477197	31477197	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-A4IG-01A-11D-A25Y-08	TCGA-BA-A4IG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	200d5ad1-bd1f-4068-a4e4-4b6a3aaaf92d	df122b02-6d09-4441-af8a-cae70fd20fff	g.chr16:31477197G>T	ENST00000408912.3	+	7	2493	c.2176G>T	c.(2176-2178)Gtt>Ttt	p.V726F	ARMC5_ENST00000412665.2_Missense_Mutation_p.V275F|ARMC5_ENST00000538189.1_Missense_Mutation_p.V663F|ARMC5_ENST00000457010.2_3'UTR|ARMC5_ENST00000268314.4_Missense_Mutation_p.V631F|ARMC5_ENST00000563544.1_Missense_Mutation_p.V631F			Q96C12	ARMC5_HUMAN	armadillo repeat containing 5	631							binding			central_nervous_system(1)|endometrium(4)|large_intestine(3)|liver(2)|lung(12)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	28						GAACCTGACGGTTCAGGCTGA	0.637000													5	34					1	1	1	1	0
DOT1L	84444	broad.mit.edu	37	19	2216347	2216347	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-A4IG-01A-11D-A25Y-08	TCGA-BA-A4IG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	200d5ad1-bd1f-4068-a4e4-4b6a3aaaf92d	df122b02-6d09-4441-af8a-cae70fd20fff	g.chr19:2216347C>T	ENST00000398665.3	+	20	2027	c.1991C>T	c.(1990-1992)cCg>cTg	p.P664L		NM_032482.2	NP_115871.1	Q8TEK3	DOT1L_HUMAN	DOT1-like histone H3K79 methyltransferase	664						nucleus	DNA binding|histone-lysine N-methyltransferase activity|protein binding			NS(1)|breast(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(3)|lung(14)|ovary(2)|pancreas(2)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(9)	42		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TCCTGTGTGCCGCCTGACGAC	0.682000													21	67					0	0	1	0	0
TRIM59	286827	broad.mit.edu	37	3	160156358	160156358	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-A4IG-01A-11D-A25Y-08	TCGA-BA-A4IG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	200d5ad1-bd1f-4068-a4e4-4b6a3aaaf92d	df122b02-6d09-4441-af8a-cae70fd20fff	g.chr3:160156358G>A	ENST00000543469.1	-	2	828	c.614C>T	c.(613-615)aCg>aTg	p.T205M	TRIM59_ENST00000309784.4_Missense_Mutation_p.T205M|RP11-432B6.3_ENST00000483754.1_Missense_Mutation_p.T205M			Q8IWR1	TRI59_HUMAN	tripartite motif containing 59	205						integral to membrane|intracellular	zinc ion binding			breast(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(2)|lung(2)|ovary(1)|urinary_tract(3)	15			Lung(72;0.00334)|LUSC - Lung squamous cell carcinoma(72;0.00523)			ACAGAGAGCCGTTAGGAAACT	0.358000													117	133					0	0	1	0	0
MRPS15	64960	broad.mit.edu	37	1	36926340	36926340	+	Missense_Mutation	SNP	T	T	C			TCGA-BA-A4IG-01A-11D-A25Y-08	TCGA-BA-A4IG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	200d5ad1-bd1f-4068-a4e4-4b6a3aaaf92d	df122b02-6d09-4441-af8a-cae70fd20fff	g.chr1:36926340T>C	ENST00000373116.5	-	5	499	c.338A>G	c.(337-339)aAg>aGg	p.K113R		NM_031280.3	NP_112570.2	P82914	RT15_HUMAN	mitochondrial ribosomal protein S15	113					translation	mitochondrial small ribosomal subunit|nuclear membrane	structural constituent of ribosome			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(1)|lung(6)|ovary(1)	14		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				AACAATCTTCTTCATAAACTG	0.512000													21	46					0	0	1	0	0
ZNF358	140467	broad.mit.edu	37	19	7585034	7585034	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-A4IG-01A-11D-A25Y-08	TCGA-BA-A4IG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	200d5ad1-bd1f-4068-a4e4-4b6a3aaaf92d	df122b02-6d09-4441-af8a-cae70fd20fff	g.chr19:7585034G>C	ENST00000597229.1	+	2	1076	c.906G>C	c.(904-906)caG>caC	p.Q302H	CTD-2207O23.11_ENST00000602083.1_RNA|ZNF358_ENST00000394341.2_Missense_Mutation_p.Q302H	NM_018083.4	NP_060553.4	Q9NW07	ZN358_HUMAN	zinc finger protein 358	302					embryonic forelimb morphogenesis|neural tube development|regulation of transcription, DNA-dependent|stem cell maintenance|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|kidney(1)|lung(1)|skin(2)	8						CCTTCGGGCAGAGCTCGGCGC	0.701000													18	38					0	0	1	0	0
ANKLE2	23141	broad.mit.edu	37	12	133327346	133327346	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-A4IG-01A-11D-A25Y-08	TCGA-BA-A4IG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	200d5ad1-bd1f-4068-a4e4-4b6a3aaaf92d	df122b02-6d09-4441-af8a-cae70fd20fff	g.chr12:133327346C>T	ENST00000539605.1	-	2	7228	c.544G>A	c.(544-546)Gaa>Aaa	p.E182K	ANKLE2_ENST00000337516.5_Missense_Mutation_p.E244K|ANKLE2_ENST00000357997.5_Missense_Mutation_p.E244K			Q86XL3	ANKL2_HUMAN	ankyrin repeat and LEM domain containing 2	244						cytoplasm|integral to membrane|nuclear envelope				NS(2)|autonomic_ganglia(1)|breast(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(4)|lung(20)|ovary(1)|urinary_tract(2)	45	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0176)|Lung NSC(355;0.204)		OV - Ovarian serous cystadenocarcinoma(86;2.3e-08)|Epithelial(86;1.56e-07)|all cancers(50;4.94e-06)		TCAGCGTCTTCTCTGGTAGAA	0.393000													33	86					0	0	1	0	0
ZNF334	55713	broad.mit.edu	37	20	45130958	45130958	+	Missense_Mutation	SNP	G	G	C	rs35251052		TCGA-BA-A4IG-01A-11D-A25Y-08	TCGA-BA-A4IG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	200d5ad1-bd1f-4068-a4e4-4b6a3aaaf92d	df122b02-6d09-4441-af8a-cae70fd20fff	g.chr20:45130958G>C	ENST00000457685.2	-	6	2229	c.906C>G	c.(904-906)ttC>ttG	p.F302L	ZNF334_ENST00000347606.4_Missense_Mutation_p.F340L|ZNF334_ENST00000593880.1_Missense_Mutation_p.F363L			Q9HCZ1	ZN334_HUMAN	zinc finger protein 334	340					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(8)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	32		Myeloproliferative disorder(115;0.0122)				TGTGTGACCTGAAATGTTCAG	0.438000													16	239					0	0	1	0	0
SMARCD2	6603	broad.mit.edu	37	17	61910996	61910996	+	Missense_Mutation	SNP	A	A	G			TCGA-BA-A4IG-01A-11D-A25Y-08	TCGA-BA-A4IG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	200d5ad1-bd1f-4068-a4e4-4b6a3aaaf92d	df122b02-6d09-4441-af8a-cae70fd20fff	g.chr17:61910996A>G	ENST00000448276.2	-	10	1533	c.1268T>C	c.(1267-1269)tTt>tCt	p.F423S	SMARCD2_ENST00000323347.10_Missense_Mutation_p.F375S|SMARCD2_ENST00000225742.9_Missense_Mutation_p.F348S	NM_001098426.1	NP_001091896.1	Q92925	SMRD2_HUMAN	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2	423					chromatin modification|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	SWI/SNF complex	protein binding|transcription coactivator activity			central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(1)|lung(1)	8						AGAGGCCAGAAAATTGCTCAT	0.582000													18	87					0	0	1	0	0
INPPL1	3636	broad.mit.edu	37	11	71946742	71946742	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-A4IG-01A-11D-A25Y-08	TCGA-BA-A4IG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	200d5ad1-bd1f-4068-a4e4-4b6a3aaaf92d	df122b02-6d09-4441-af8a-cae70fd20fff	g.chr11:71946742G>A	ENST00000298229.2	+	24	2887	c.2683G>A	c.(2683-2685)Gag>Aag	p.E895K	INPPL1_ENST00000541756.1_Missense_Mutation_p.E653K|INPPL1_ENST00000538751.1_Missense_Mutation_p.E653K	NM_001567.3	NP_001558.3	O15357	SHIP2_HUMAN	inositol polyphosphate phosphatase-like 1	895					actin filament organization|cell adhesion|endocytosis	actin cortical patch|cytosol	actin binding|SH2 domain binding|SH3 domain binding			breast(2)|endometrium(9)|kidney(1)|large_intestine(7)|lung(12)|ovary(1)|pancreas(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	44						TGATAAGGATGAGGCAGGAGC	0.602000													27	51					0	0	1	0	0
SDE2	163859	broad.mit.edu	37	1	226173192	226173192	+	Silent	SNP	C	C	T			TCGA-BA-A4IG-01A-11D-A25Y-08	TCGA-BA-A4IG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	200d5ad1-bd1f-4068-a4e4-4b6a3aaaf92d	df122b02-6d09-4441-af8a-cae70fd20fff	g.chr1:226173192C>T	ENST00000272091.7	-	7	1185	c.1167G>A	c.(1165-1167)gcG>gcA	p.A389A	SDE2_ENST00000366817.1_Silent_p.A294A	NM_152608.3	NP_689821.3			SDE2 telomere maintenance homolog (S. pombe)									p.A377A(1)|p.A389A(1)									CAGAGGTGAACGCCAATAAAT	0.428000													19	70					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179593405	179593405	+	Silent	SNP	C	C	A			TCGA-BA-A4IG-01A-11D-A25Y-08	TCGA-BA-A4IG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	200d5ad1-bd1f-4068-a4e4-4b6a3aaaf92d	df122b02-6d09-4441-af8a-cae70fd20fff	g.chr2:179593405C>A	ENST00000589042.1	-	66	19472	c.19248G>T	c.(19246-19248)gtG>gtT	p.V6416V	TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron|TTN_ENST00000359218.5_Intron|TTN_ENST00000342992.6_Silent_p.V5172V|TTN_ENST00000591111.1_Silent_p.V6099V|TTN_ENST00000342175.6_Intron	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	6099	Ig-like 45.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TAAGCCATTTCACTTTGAGTT	0.393000													25	44					6.21321e-17	7.16909e-17	1	1	0
KCNK15	60598	broad.mit.edu	37	20	43379120	43379120	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-A4IG-01A-11D-A25Y-08	TCGA-BA-A4IG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	200d5ad1-bd1f-4068-a4e4-4b6a3aaaf92d	df122b02-6d09-4441-af8a-cae70fd20fff	g.chr20:43379120G>C	ENST00000372861.3	+	2	765	c.634G>C	c.(634-636)Gag>Cag	p.E212Q		NM_022358.3	NP_071753.2	Q9H427	KCNKF_HUMAN	potassium channel, subfamily K, member 15	212						integral to membrane	potassium channel activity|voltage-gated ion channel activity			NS(1)|endometrium(1)|large_intestine(2)|lung(4)|upper_aerodigestive_tract(2)	10		Myeloproliferative disorder(115;0.0122)				GCAGAGCGGCGAGGCGCTGCA	0.622000													9	57					0	0	1	0	0
PRCC	5546	broad.mit.edu	37	1	156756871	156756871	+	Missense_Mutation	SNP	A	A	G			TCGA-BA-A4IG-01A-11D-A25Y-08	TCGA-BA-A4IG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	200d5ad1-bd1f-4068-a4e4-4b6a3aaaf92d	df122b02-6d09-4441-af8a-cae70fd20fff	g.chr1:156756871A>G	ENST00000271526.4	+	3	1260	c.988A>G	c.(988-990)Agt>Ggt	p.S330G	PRCC_ENST00000491853.1_3'UTR|PRCC_ENST00000353233.3_Missense_Mutation_p.S330G	NM_005973.4	NP_005964.3	Q92733	PRCC_HUMAN	papillary renal cell carcinoma (translocation-associated)	330					cell cycle|mitotic cell cycle checkpoint	nucleus	protein binding		PRCC/TFE3(25)	breast(1)|central_nervous_system(3)|endometrium(1)|kidney(2)|large_intestine(1)|liver(1)|lung(5)|upper_aerodigestive_tract(1)	15	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					AGCAGGTTCAAGTGGGGCCCC	0.567000			T	TFE3	papillary renal								41	251					0	0	1	0	0
NUP155	9631	broad.mit.edu	37	5	37363995	37363995	+	Silent	SNP	C	C	T			TCGA-BA-A4IG-01A-11D-A25Y-08	TCGA-BA-A4IG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	200d5ad1-bd1f-4068-a4e4-4b6a3aaaf92d	df122b02-6d09-4441-af8a-cae70fd20fff	g.chr5:37363995C>T	ENST00000231498.3	-	3	590	c.387G>A	c.(385-387)gaG>gaA	p.E129E	NUP155_ENST00000513532.1_Silent_p.E129E|NUP155_ENST00000381843.2_Silent_p.E70E	NM_153485.1	NP_705618.1	O75694	NU155_HUMAN	nucleoporin 155kDa	129					carbohydrate metabolic process|glucose transport|mRNA transport|nucleocytoplasmic transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear membrane|nuclear pore	protein binding|structural constituent of nuclear pore|transporter activity			endometrium(1)|kidney(16)|large_intestine(5)|lung(29)|ovary(2)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	62	all_lung(31;0.000137)		COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			CATACCCATCCTCATAGTTCC	0.393000													41	52					0	0	1	0	0
ACY1	95	broad.mit.edu	37	3	52022615	52022615	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-A4IG-01A-11D-A25Y-08	TCGA-BA-A4IG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	200d5ad1-bd1f-4068-a4e4-4b6a3aaaf92d	df122b02-6d09-4441-af8a-cae70fd20fff	g.chr3:52022615G>A	ENST00000458031.2	+	15	1498	c.1267G>A	c.(1267-1269)Gat>Aat	p.D423N	ABHD14A-ACY1_ENST00000463937.1_Missense_Mutation_p.D434N|ACY1_ENST00000494103.1_Missense_Mutation_p.D261N|ACY1_ENST00000404366.2_Missense_Mutation_p.D333N|ACY1_ENST00000476854.1_Missense_Mutation_p.D268N|ACY1_ENST00000476351.1_Missense_Mutation_p.D298N			Q03154	ACY1_HUMAN	aminoacylase 1	333					cellular amino acid metabolic process|proteolysis	cytosol	aminoacylase activity|metal ion binding|metallopeptidase activity			breast(1)|endometrium(1)|large_intestine(3)|lung(4)|ovary(1)|skin(1)	11				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.000534)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)	L-Aspartic Acid(DB00128)	GGTCTGCAAGGATATGTGAGC	0.592000													12	81					0	0	1	0	0
ABCC11	85320	broad.mit.edu	37	16	48256716	48256716	+	Silent	SNP	T	T	C			TCGA-BA-A4IG-01A-11D-A25Y-08	TCGA-BA-A4IG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	200d5ad1-bd1f-4068-a4e4-4b6a3aaaf92d	df122b02-6d09-4441-af8a-cae70fd20fff	g.chr16:48256716T>C	ENST00000394747.1	-	5	919	c.570A>G	c.(568-570)gaA>gaG	p.E190E	ABCC11_ENST00000356608.2_Silent_p.E190E|ABCC11_ENST00000537808.1_Silent_p.E190E|ABCC11_ENST00000394748.1_Silent_p.E190E|ABCC11_ENST00000353782.5_Silent_p.E190E	NM_033151.3	NP_149163.2	Q96J66	ABCCB_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 11	190	ABC transmembrane type-1 1.					integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(3)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(42)|ovary(3)|prostate(2)|skin(5)|urinary_tract(2)	83		all_cancers(37;0.127)|all_lung(18;0.132)|Breast(268;0.166)				CTTCTGAATATTCCAGGATCT	0.443000													16	45					0	0	1	0	0
VPS13B	157680	broad.mit.edu	37	8	100779109	100779109	+	Silent	SNP	C	C	T			TCGA-BA-A4IG-01A-11D-A25Y-08	TCGA-BA-A4IG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	200d5ad1-bd1f-4068-a4e4-4b6a3aaaf92d	df122b02-6d09-4441-af8a-cae70fd20fff	g.chr8:100779109C>T	ENST00000358544.2	+	40	7344	c.7233C>T	c.(7231-7233)atC>atT	p.I2411I	VPS13B_ENST00000357162.2_Silent_p.I2386I|VPS13B_ENST00000395996.1_3'UTR	NM_017890.4	NP_060360.3	Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13 homolog B (yeast)	2411					protein transport					NS(1)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(37)|lung(78)|ovary(8)|pancreas(3)|prostate(5)|skin(9)|upper_aerodigestive_tract(4)|urinary_tract(9)	193	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			TGCCGGATATCAATCTCGTGA	0.383000													8	87					0	0	1	0	0
FIGNL1	63979	broad.mit.edu	37	7	50514663	50514663	+	Missense_Mutation	SNP	T	T	C			TCGA-BA-A4IG-01A-11D-A25Y-08	TCGA-BA-A4IG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	200d5ad1-bd1f-4068-a4e4-4b6a3aaaf92d	df122b02-6d09-4441-af8a-cae70fd20fff	g.chr7:50514663T>C	ENST00000419119.1	-	2	1876	c.323A>G	c.(322-324)aAt>aGt	p.N108S	FIGNL1_ENST00000435566.1_3'UTR|FIGNL1_ENST00000433017.1_Missense_Mutation_p.N108S|FIGNL1_ENST00000395556.2_Missense_Mutation_p.N108S|FIGNL1_ENST00000356889.4_Missense_Mutation_p.N108S			Q6PIW4	FIGL1_HUMAN	fidgetin-like 1	108					ATP metabolic process|negative regulation of apoptosis|osteoblast differentiation|osteoblast proliferation|regulation of cell cycle	cytoplasm|nucleus	ATP binding|magnesium ion binding|nucleoside-triphosphatase activity			endometrium(3)|kidney(1)|large_intestine(5)|lung(13)|ovary(3)|prostate(3)|upper_aerodigestive_tract(1)	29	Glioma(55;0.08)|all_neural(89;0.245)	Acute lymphoblastic leukemia(4;3.73e-08)|all_hematologic(4;7.51e-06)				TTTGAAAACATTATTTATTGA	0.368000													43	70					0	0	1	0	0
CFB	629	broad.mit.edu	37	6	31907070	31907070	+	Missense_Mutation	SNP	A	A	G			TCGA-BA-A4IG-01A-11D-A25Y-08	TCGA-BA-A4IG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	200d5ad1-bd1f-4068-a4e4-4b6a3aaaf92d	df122b02-6d09-4441-af8a-cae70fd20fff	g.chr6:31907070A>G	ENST00000456570.1	+	6	788	c.733A>G	c.(733-735)Atc>Gtc	p.I245V	C2_ENST00000299367.5_Missense_Mutation_p.I398V|CFB_ENST00000556679.1_Missense_Mutation_p.I245V|C2_ENST00000469372.1_Missense_Mutation_p.I152V|CFB_ENST00000477310.1_Missense_Mutation_p.I216V|C2_ENST00000442278.2_Missense_Mutation_p.I266V|C2_ENST00000452323.2_Missense_Mutation_p.I184V			P00751	CFAB_HUMAN	complement factor B	411					complement activation, alternative pathway|proteolysis	extracellular region|plasma membrane	complement binding|serine-type endopeptidase activity			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(10)|pancreas(1)|skin(1)|urinary_tract(1)	21						GATCCTGAACATCAACCAGAA	0.468000													9	68					0	0	1	0	0
APOBEC3D	140564	broad.mit.edu	37	22	39427873	39427873	+	Missense_Mutation	SNP	A	A	G			TCGA-BA-A4IG-01A-11D-A25Y-08	TCGA-BA-A4IG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	200d5ad1-bd1f-4068-a4e4-4b6a3aaaf92d	df122b02-6d09-4441-af8a-cae70fd20fff	g.chr22:39427873A>G	ENST00000216099.7	+	6	1344	c.937A>G	c.(937-939)Acc>Gcc	p.T313A	APOBEC3D_ENST00000427494.2_Missense_Mutation_p.T129A|APOBEC3D_ENST00000381568.4_Missense_Mutation_p.T313A	NM_152426.3	NP_689639.2	Q96AK3	ABC3D_HUMAN	apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D	313					negative regulation of transposition		hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines|zinc ion binding			breast(1)|cervix(1)|endometrium(2)|large_intestine(2)|lung(3)|prostate(2)	11	Melanoma(58;0.04)					CGTGAATCTCACCATCTTCAC	0.587000													24	104					0	0	1	0	0
SEMA3G	56920	broad.mit.edu	37	3	52469793	52469793	+	Nonsense_Mutation	SNP	G	G	T			TCGA-BA-A4IG-01A-11D-A25Y-08	TCGA-BA-A4IG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	200d5ad1-bd1f-4068-a4e4-4b6a3aaaf92d	df122b02-6d09-4441-af8a-cae70fd20fff	g.chr3:52469793G>T	ENST00000231721.2	-	16	2174	c.2175C>A	c.(2173-2175)taC>taA	p.Y725*		NM_020163.1	NP_064548.1	Q9NS98	SEM3G_HUMAN	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G	725					multicellular organismal development	extracellular region|membrane	receptor activity			kidney(1)|large_intestine(5)|lung(8)|ovary(2)|prostate(1)|skin(1)	18				BRCA - Breast invasive adenocarcinoma(193;1.69e-05)|Kidney(197;0.00173)|KIRC - Kidney renal clear cell carcinoma(197;0.00196)|OV - Ovarian serous cystadenocarcinoma(275;0.0333)		CGCGCTCACAGTACTCATCCA	0.687000													26	75					3.6726e-16	4.21063e-16	1	1	0
KIAA0319L	79932	broad.mit.edu	37	1	35936496	35936496	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-A4IG-01A-11D-A25Y-08	TCGA-BA-A4IG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	200d5ad1-bd1f-4068-a4e4-4b6a3aaaf92d	df122b02-6d09-4441-af8a-cae70fd20fff	g.chr1:35936496C>A	ENST00000325722.3	-	6	1315	c.1081G>T	c.(1081-1083)Ggg>Tgg	p.G361W	KIAA0319L_ENST00000485551.1_5'UTR	NM_024874.4	NP_079150.3	Q8IZA0	K319L_HUMAN	KIAA0319-like	361	PKD 1.					cytoplasmic vesicle part|integral to membrane	protein binding			breast(1)|endometrium(2)|kidney(3)|large_intestine(7)|lung(12)|pancreas(1)|prostate(2)|skin(4)|stomach(1)|urinary_tract(1)	34		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				GAATGTTTCCCTTCCATTTCT	0.418000													10	98					6.40141e-05	6.77796e-05	1	1	0
PRKCI	5584	broad.mit.edu	37	3	169940505	169940505	+	Silent	SNP	C	C	T			TCGA-BA-A4IG-01A-11D-A25Y-08	TCGA-BA-A4IG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	200d5ad1-bd1f-4068-a4e4-4b6a3aaaf92d	df122b02-6d09-4441-af8a-cae70fd20fff	g.chr3:169940505C>T	ENST00000295797.4	+	1	353	c.48C>T	c.(46-48)ggC>ggT	p.G16G		NM_002740.5	NP_002731.4	P41743	KPCI_HUMAN	protein kinase C, iota	16	Regulatory domain.|Required for interaction with RAB2.				anti-apoptosis|cellular membrane organization|cellular response to insulin stimulus|establishment or maintenance of epithelial cell apical/basal polarity|intracellular signal transduction|nerve growth factor receptor signaling pathway|positive regulation of establishment of protein localization in plasma membrane|positive regulation of glucose import|protein targeting to membrane|secretion|tight junction assembly|vesicle-mediated transport	cytosol|endosome|nucleus|polarisome	ATP binding|phospholipid binding|protein binding|protein kinase C activity|zinc ion binding			breast(2)|endometrium(5)|kidney(1)|large_intestine(4)|lung(16)|ovary(2)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	36	all_cancers(22;6.45e-23)|all_epithelial(15;8.52e-28)|all_lung(20;6.31e-17)|Lung NSC(18;2.61e-16)|Ovarian(172;0.000337)|Breast(254;0.169)		Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.197)			CGGTCGCAGGCGGCGGCAGCG	0.721000													3	10					0	0	1	0	0
POTEA	340441	broad.mit.edu	37	8	43173690	43173690	+	RNA	SNP	G	G	C			TCGA-BA-A4IG-01A-11D-A25Y-08	TCGA-BA-A4IG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	200d5ad1-bd1f-4068-a4e4-4b6a3aaaf92d	df122b02-6d09-4441-af8a-cae70fd20fff	g.chr8:43173690G>C	ENST00000522175.2	+	0	976							Q6S8J7	POTEA_HUMAN	POTE ankyrin domain family, member A											breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(27)|ovary(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	46						GGTGATGGTGGATTAGTTCCA	0.413000													74	70					0	0	1	0	0
NCAN	1463	broad.mit.edu	37	19	19338281	19338281	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-A4IG-01A-11D-A25Y-08	TCGA-BA-A4IG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	200d5ad1-bd1f-4068-a4e4-4b6a3aaaf92d	df122b02-6d09-4441-af8a-cae70fd20fff	g.chr19:19338281C>T	ENST00000252575.5	+	8	1895	c.1852C>T	c.(1852-1854)Ccc>Tcc	p.P618S	NCAN_ENST00000538881.1_Missense_Mutation_p.P69S	NM_004386.2	NP_004377.2	O14594	NCAN_HUMAN	neurocan	618					axon guidance|cell adhesion	extracellular region	calcium ion binding|hyaluronic acid binding|sugar binding			breast(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(32)|ovary(5)|pancreas(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	64			Epithelial(12;0.00544)			CAGCCCTGCCCCCTGGGAGGC	0.647000													5	69					0	0	1	0	0
ZNF608	57507	broad.mit.edu	37	5	123983485	123983485	+	Silent	SNP	C	C	A			TCGA-BA-A4IG-01A-11D-A25Y-08	TCGA-BA-A4IG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	200d5ad1-bd1f-4068-a4e4-4b6a3aaaf92d	df122b02-6d09-4441-af8a-cae70fd20fff	g.chr5:123983485C>A	ENST00000306315.5	-	4	3027	c.2592G>T	c.(2590-2592)ctG>ctT	p.L864L	ZNF608_ENST00000504926.1_Silent_p.L437L	NM_020747.2	NP_065798.2	Q9ULD9	ZN608_HUMAN	zinc finger protein 608	864						intracellular	zinc ion binding			breast(4)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(8)|lung(12)|ovary(3)|skin(6)|urinary_tract(1)	46		all_cancers(142;0.186)|Prostate(80;0.081)	KIRC - Kidney renal clear cell carcinoma(527;0.159)|Kidney(363;0.221)	OV - Ovarian serous cystadenocarcinoma(64;0.00126)|Epithelial(69;0.00238)|all cancers(49;0.00783)		GTCCATTTGCCAGCCCTTCAT	0.502000													16	98					2.23348e-06	2.43653e-06	1	1	0
ZNF551	90233	broad.mit.edu	37	19	58198984	58198984	+	Nonsense_Mutation	SNP	T	T	A			TCGA-BA-A4IG-01A-11D-A25Y-08	TCGA-BA-A4IG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	200d5ad1-bd1f-4068-a4e4-4b6a3aaaf92d	df122b02-6d09-4441-af8a-cae70fd20fff	g.chr19:58198984T>A	ENST00000282296.5	+	3	1526	c.1341T>A	c.(1339-1341)taT>taA	p.Y447*	AC003006.7_ENST00000596085.1_Intron|AC003006.7_ENST00000599221.1_Intron|ZNF551_ENST00000356715.4_Nonsense_Mutation_p.Y431*	NM_001270938.1	NP_001257867.1	Q7Z340	ZN551_HUMAN	zinc finger protein 551	447					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(4)|large_intestine(5)|lung(4)|ovary(1)|prostate(1)	15		Colorectal(82;0.000256)|all_neural(62;0.0577)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0257)		AAAGACCTTATGAATGCAGAG	0.433000													34	89					0	0	1	0	0
ERBB2IP	55914	broad.mit.edu	37	5	65350591	65350591	+	Missense_Mutation	SNP	A	A	T			TCGA-BA-A4IG-01A-11D-A25Y-08	TCGA-BA-A4IG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	200d5ad1-bd1f-4068-a4e4-4b6a3aaaf92d	df122b02-6d09-4441-af8a-cae70fd20fff	g.chr5:65350591A>T	ENST00000284037.5	+	21	3834	c.3445A>T	c.(3445-3447)Att>Ttt	p.I1149F	ERBB2IP_ENST00000380936.1_Missense_Mutation_p.I1149F|ERBB2IP_ENST00000506030.1_Missense_Mutation_p.I1149F|ERBB2IP_ENST00000380938.2_Missense_Mutation_p.I1149F|ERBB2IP_ENST00000416865.2_Intron|ERBB2IP_ENST00000380943.2_Missense_Mutation_p.I1149F|ERBB2IP_ENST00000511297.1_Missense_Mutation_p.I1145F|ERBB2IP_ENST00000508515.1_Missense_Mutation_p.I1149F|ERBB2IP_ENST00000380935.1_Missense_Mutation_p.I1149F|ERBB2IP_ENST00000380939.2_Missense_Mutation_p.I1149F	NM_001253697.1	NP_001240626.1	Q96RT1	LAP2_HUMAN	erbb2 interacting protein	1149					basal protein localization|cell adhesion|cell cycle|cell growth|epidermal growth factor receptor signaling pathway|establishment or maintenance of epithelial cell apical/basal polarity|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization	basement membrane|cytoplasm|hemidesmosome|nucleus	ErbB-2 class receptor binding|integrin binding|structural constituent of cytoskeleton			breast(2)|central_nervous_system(2)|endometrium(3)|kidney(5)|large_intestine(8)|lung(11)|ovary(3)|skin(2)	36		Lung NSC(167;9.45e-06)|Prostate(74;0.0139)|Ovarian(174;0.0547)|Breast(144;0.093)|Colorectal(97;0.234)		UCEC - Uterine corpus endometrioid carcinoma (4;0.0767)|Lung(70;0.00191)		TCGACCCTCTATTAATGAAAT	0.433000													11	55					0	0	1	0	0
EVA1A	84141	broad.mit.edu	37	2	75720529	75720529	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-A4IG-01A-11D-A25Y-08	TCGA-BA-A4IG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	200d5ad1-bd1f-4068-a4e4-4b6a3aaaf92d	df122b02-6d09-4441-af8a-cae70fd20fff	g.chr2:75720529G>A	ENST00000233712.1	-	4	729	c.292C>T	c.(292-294)Cgg>Tgg	p.R98W	EVA1A_ENST00000410113.1_Missense_Mutation_p.R98W|EVA1A_ENST00000393913.3_Missense_Mutation_p.R98W|EVA1A_ENST00000410071.1_Missense_Mutation_p.R98W|EVA1A_ENST00000410010.1_Missense_Mutation_p.R86W|EVA1A_ENST00000490746.1_Intron	NM_032181.2	NP_115557.1			eva-1 homolog A (C. elegans)																		CGGTGTCTCCGCACGGAGAGA	0.637000													19	46					0	0	1	0	0
OR10S1	219873	broad.mit.edu	37	11	123847864	123847864	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-A4IG-01A-11D-A25Y-08	TCGA-BA-A4IG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	200d5ad1-bd1f-4068-a4e4-4b6a3aaaf92d	df122b02-6d09-4441-af8a-cae70fd20fff	g.chr11:123847864G>A	ENST00000531945.1	-	1	624	c.535C>T	c.(535-537)Cgc>Tgc	p.R179C		NM_001004474.1	NP_001004474.1	Q8NGN2	O10S1_HUMAN	olfactory receptor, family 10, subfamily S, member 1	179					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.R179C(1)		endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(16)|ovary(1)|prostate(2)|skin(2)|urinary_tract(1)	36		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0399)		TAGAGCAGGCGGAAGGTGAGG	0.552000													17	33					0	0	1	0	0
ARID2	196528	broad.mit.edu	37	12	46245425	46245425	+	Silent	SNP	C	C	A			TCGA-BA-A4IG-01A-11D-A25Y-08	TCGA-BA-A4IG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	200d5ad1-bd1f-4068-a4e4-4b6a3aaaf92d	df122b02-6d09-4441-af8a-cae70fd20fff	g.chr12:46245425C>A	ENST00000334344.6	+	15	3691	c.3519C>A	c.(3517-3519)acC>acA	p.T1173T	ARID2_ENST00000444670.1_Silent_p.T783T|ARID2_ENST00000422737.1_Silent_p.T1024T|ARID2_ENST00000479608.1_3'UTR	NM_152641.2	NP_689854.2	Q68CP9	ARID2_HUMAN	AT rich interactive domain 2 (ARID, RFX-like)	1173					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(7)|central_nervous_system(3)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(21)|liver(20)|lung(34)|ovary(7)|pancreas(1)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	116	Lung SC(27;0.192)|Renal(347;0.236)	Lung NSC(34;0.106)|all_lung(34;0.22)	OV - Ovarian serous cystadenocarcinoma(5;0.00691)	GBM - Glioblastoma multiforme(48;0.0153)		ACCAGGTAACCATAACAGTTG	0.468000			"""N, S, F"""		hepatocellular carcinoma								7	90					1.06961e-07	1.18846e-07	1	1	0
KIAA1407	57577	broad.mit.edu	37	3	113723568	113723568	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-A4IG-01A-11D-A25Y-08	TCGA-BA-A4IG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	200d5ad1-bd1f-4068-a4e4-4b6a3aaaf92d	df122b02-6d09-4441-af8a-cae70fd20fff	g.chr3:113723568C>T	ENST00000295878.3	-	11	2040	c.1894G>A	c.(1894-1896)Gaa>Aaa	p.E632K	KIAA1407_ENST00000545063.1_Missense_Mutation_p.E463K	NM_020817.1	NP_065868.1	Q8NCU4	K1407_HUMAN	KIAA1407	632										endometrium(9)|large_intestine(7)|lung(19)|ovary(2)|pancreas(1)|prostate(1)|urinary_tract(1)	40						CTTCTGCCTTCAGTCCCAGGG	0.453000													31	175					0	0	1	0	0
MTFR1	9650	broad.mit.edu	37	8	66619352	66619352	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-A4IG-01A-11D-A25Y-08	TCGA-BA-A4IG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	200d5ad1-bd1f-4068-a4e4-4b6a3aaaf92d	df122b02-6d09-4441-af8a-cae70fd20fff	g.chr8:66619352G>C	ENST00000262146.4	+	6	751	c.625G>C	c.(625-627)Gat>Cat	p.D209H	MTFR1_ENST00000517944.1_3'UTR|MTFR1_ENST00000458689.2_Missense_Mutation_p.D176H	NM_014637.3	NP_055452.3	Q15390	MTFR1_HUMAN	mitochondrial fission regulator 1	209						mitochondrion|plasma membrane				cervix(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(1)|pancreas(1)|urinary_tract(1)	11			Epithelial(68;0.0526)|BRCA - Breast invasive adenocarcinoma(89;0.156)|all cancers(69;0.171)|OV - Ovarian serous cystadenocarcinoma(28;0.194)			ATCTGCTGTTGATCTGATTAA	0.483000													19	100					0	0	1	0	0
MAP3K9	4293	broad.mit.edu	37	14	71205062	71205062	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-A4IG-01A-11D-A25Y-08	TCGA-BA-A4IG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	200d5ad1-bd1f-4068-a4e4-4b6a3aaaf92d	df122b02-6d09-4441-af8a-cae70fd20fff	g.chr14:71205062C>G	ENST00000554752.2	-	8	1743	c.1744G>C	c.(1744-1746)Gag>Cag	p.E582Q	MAP3K9_ENST00000553414.1_Missense_Mutation_p.E324Q|MAP3K9_ENST00000555993.2_Missense_Mutation_p.E582Q|MAP3K9_ENST00000554146.1_Missense_Mutation_p.E319Q|MAP3K9_ENST00000381250.4_Missense_Mutation_p.E582Q			P80192	M3K9_HUMAN	mitogen-activated protein kinase kinase kinase 9	582					activation of JUN kinase activity|protein autophosphorylation		ATP binding|JUN kinase kinase kinase activity|MAP kinase kinase activity|protein homodimerization activity			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(25)|ovary(2)|prostate(1)|skin(3)|stomach(2)	46				all cancers(60;0.00779)|BRCA - Breast invasive adenocarcinoma(234;0.00884)|OV - Ovarian serous cystadenocarcinoma(108;0.08)		TCCCCTTCCTCCTTTGGGACG	0.572000													17	85					0	0	1	0	0
RAPGEF1	2889	broad.mit.edu	37	9	134526228	134526228	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-A4IG-01A-11D-A25Y-08	TCGA-BA-A4IG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	200d5ad1-bd1f-4068-a4e4-4b6a3aaaf92d	df122b02-6d09-4441-af8a-cae70fd20fff	g.chr9:134526228G>A	ENST00000372195.1	-	2	413	c.170C>T	c.(169-171)tCc>tTc	p.S57F	RAPGEF1_ENST00000372189.3_Missense_Mutation_p.S40F|RAPGEF1_ENST00000372190.3_Missense_Mutation_p.S58F			Q13905	RPGF1_HUMAN	Rap guanine nucleotide exchange factor (GEF) 1	40					activation of MAPKK activity|nerve growth factor receptor signaling pathway|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|endosome	guanyl-nucleotide exchange factor activity|SH3 domain binding			NS(2)|breast(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|large_intestine(8)|lung(9)|ovary(2)|prostate(4)|skin(1)|urinary_tract(1)	39		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;2.19e-05)|Epithelial(140;0.000364)		AATCTTTACGGACACCTCAGC	0.458000													14	150					0	0	1	0	0
ZNF335	63925	broad.mit.edu	37	20	44581078	44581078	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-A4IG-01A-11D-A25Y-08	TCGA-BA-A4IG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	200d5ad1-bd1f-4068-a4e4-4b6a3aaaf92d	df122b02-6d09-4441-af8a-cae70fd20fff	g.chr20:44581078C>T	ENST00000322927.2	-	20	2997	c.2897G>A	c.(2896-2898)gGa>gAa	p.G966E	ZNF335_ENST00000426788.1_Missense_Mutation_p.G811E	NM_022095.3	NP_071378.1	Q9H4Z2	ZN335_HUMAN	zinc finger protein 335	966					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(2)|endometrium(3)|kidney(1)|large_intestine(13)|lung(17)|ovary(2)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	51		Myeloproliferative disorder(115;0.0122)				TCTGGGCAGTCCCCCACACTG	0.632000													18	58					0	0	1	0	0
HIF1AN	55662	broad.mit.edu	37	10	102295856	102295856	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-A4IG-01A-11D-A25Y-08	TCGA-BA-A4IG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	200d5ad1-bd1f-4068-a4e4-4b6a3aaaf92d	df122b02-6d09-4441-af8a-cae70fd20fff	g.chr10:102295856G>C	ENST00000299163.5	+	1	241	c.141G>C	c.(139-141)caG>caC	p.Q47H		NM_017902.2	NP_060372.2	Q9NWT6	HIF1N_HUMAN	hypoxia inducible factor 1, alpha subunit inhibitor	47	Interaction with VHL.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|peptide-aspartate beta-dioxygenase activity|protein binding			NS(1)|breast(1)|endometrium(2)|large_intestine(2)|lung(1)|prostate(2)|urinary_tract(1)	10		Colorectal(252;0.234)		Epithelial(162;6.75e-10)|all cancers(201;4.88e-08)		GTCTGAGTCAGAGCGACCCCC	0.642000											OREG0020442	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	9	14					0	0	1	0	0
IARS	3376	broad.mit.edu	37	9	95027389	95027389	+	Missense_Mutation	SNP	T	T	G			TCGA-BA-A4IG-01A-11D-A25Y-08	TCGA-BA-A4IG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	200d5ad1-bd1f-4068-a4e4-4b6a3aaaf92d	df122b02-6d09-4441-af8a-cae70fd20fff	g.chr9:95027389T>G	ENST00000375643.3	-	16	1788	c.1522A>C	c.(1522-1524)Att>Ctt	p.I508L	IARS_ENST00000443024.2_Missense_Mutation_p.I508L|IARS_ENST00000375629.3_5'UTR|IARS_ENST00000447699.2_Missense_Mutation_p.I398L	NM_013417.2	NP_038203.2	P41252	SYIC_HUMAN	isoleucyl-tRNA synthetase	508					isoleucyl-tRNA aminoacylation	cytosol|nucleus|soluble fraction	ATP binding|isoleucine-tRNA ligase activity|protein binding			breast(3)|endometrium(2)|kidney(4)|large_intestine(7)|lung(14)|ovary(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	35					L-Isoleucine(DB00167)	CGTGAAGGAATGGTCAGGTGG	0.433000													6	23					0	0	1	0	0
KIAA1432	57589	broad.mit.edu	37	9	5769097	5769097	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-A4IG-01A-11D-A25Y-08	TCGA-BA-A4IG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	200d5ad1-bd1f-4068-a4e4-4b6a3aaaf92d	df122b02-6d09-4441-af8a-cae70fd20fff	g.chr9:5769097G>A	ENST00000414202.2	+	22	3456	c.3265G>A	c.(3265-3267)Gaa>Aaa	p.E1089K	KIAA1432_ENST00000418622.3_Missense_Mutation_p.E1010K|KIAA1432_ENST00000251879.6_Missense_Mutation_p.E1089K|KIAA1432_ENST00000449720.2_Missense_Mutation_p.E973K|KIAA1432_ENST00000381532.2_Missense_Mutation_p.E1010K	NM_001206557.1|NM_020829.3	NP_001193486.1|NP_065880.2	Q4ADV7	RIC1_HUMAN	KIAA1432	1089						integral to membrane				breast(2)|cervix(2)|endometrium(6)|kidney(4)|large_intestine(6)|lung(23)|prostate(1)|upper_aerodigestive_tract(1)	45		Acute lymphoblastic leukemia(23;0.154)		GBM - Glioblastoma multiforme(50;0.000525)|Lung(218;0.122)		GCTGGGCTTTGAACTAATTAG	0.498000													18	178					0	0	1	0	0
SEPT8	23176	broad.mit.edu	37	5	132096852	132096852	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-A4IG-01A-11D-A25Y-08	TCGA-BA-A4IG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	200d5ad1-bd1f-4068-a4e4-4b6a3aaaf92d	df122b02-6d09-4441-af8a-cae70fd20fff	g.chr5:132096852C>G	ENST00000296873.7	-	8	1351	c.1068G>C	c.(1066-1068)gaG>gaC	p.E356D	SEPT8_ENST00000378719.2_Missense_Mutation_p.E356D|SEPT8_ENST00000378721.4_Missense_Mutation_p.E354D|SEPT8_ENST00000458488.2_Missense_Mutation_p.E356D|SEPT8_ENST00000448933.1_Missense_Mutation_p.E296D|SEPT8_ENST00000378699.2_Missense_Mutation_p.E296D|SEPT8_ENST00000378701.1_Missense_Mutation_p.E354D|SEPT8_ENST00000378706.1_Missense_Mutation_p.E356D	NM_001098812.1|NM_015146.1	NP_001092282.1|NP_055961.1	Q92599	SEPT8_HUMAN	septin 8	356					cell cycle	septin complex	GTP binding|protein binding		SEPT8/AFF4(2)	kidney(2)|lung(5)|ovary(2)|skin(1)|urinary_tract(1)	11		all_cancers(142;0.0751)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			TCAGCTCCAGCTCTGTCTCCT	0.562000													5	42					0	0	1	0	0
BAI3	577	broad.mit.edu	37	6	70082307	70082307	+	Missense_Mutation	SNP	T	T	A			TCGA-BA-A4IG-01A-11D-A25Y-08	TCGA-BA-A4IG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	200d5ad1-bd1f-4068-a4e4-4b6a3aaaf92d	df122b02-6d09-4441-af8a-cae70fd20fff	g.chr6:70082307T>A	ENST00000370598.1	+	30	5070	c.4249T>A	c.(4249-4251)Tca>Aca	p.S1417T	BAI3_ENST00000238918.8_Missense_Mutation_p.S623T|BAI3_ENST00000546190.1_Missense_Mutation_p.S381T	NM_001704.2	NP_001695.1	O60242	BAI3_HUMAN	brain-specific angiogenesis inhibitor 3	1417					negative regulation of angiogenesis|neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(2)|breast(4)|central_nervous_system(5)|endometrium(5)|kidney(2)|large_intestine(28)|liver(1)|lung(111)|ovary(10)|pancreas(4)|prostate(7)|skin(22)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	210		all_lung(197;0.212)				GAGAAGAAAATCACGATATTC	0.214000													7	23					0	0	1	0	0
WDR44	54521	broad.mit.edu	37	X	117538393	117538393	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-A4IG-01A-11D-A25Y-08	TCGA-BA-A4IG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	200d5ad1-bd1f-4068-a4e4-4b6a3aaaf92d	df122b02-6d09-4441-af8a-cae70fd20fff	g.chrX:117538393G>C	ENST00000254029.3	+	9	1762	c.1367G>C	c.(1366-1368)aGt>aCt	p.S456T	WDR44_ENST00000371822.5_Missense_Mutation_p.S431T|WDR44_ENST00000371825.3_Missense_Mutation_p.S456T	NM_019045.4	NP_061918.3	Q5JSH3	WDR44_HUMAN	WD repeat domain 44	456						cytosol|endosome membrane|Golgi apparatus|perinuclear region of cytoplasm				breast(4)|endometrium(2)|kidney(1)|large_intestine(4)|lung(16)|ovary(1)|pancreas(1)|prostate(1)|stomach(2)|upper_aerodigestive_tract(1)	33						AAAGTTAAAAGTGTTAGAGAT	0.318000													9	23					0	0	1	0	0
OR4M1	441670	broad.mit.edu	37	14	20249099	20249099	+	Silent	SNP	C	C	A			TCGA-BA-A4IG-01A-11D-A25Y-08	TCGA-BA-A4IG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	200d5ad1-bd1f-4068-a4e4-4b6a3aaaf92d	df122b02-6d09-4441-af8a-cae70fd20fff	g.chr14:20249099C>A	ENST00000315957.4	+	1	699	c.618C>A	c.(616-618)atC>atA	p.I206I		NM_001005500.1	NP_001005500.1	Q8NGD0	OR4M1_HUMAN	olfactory receptor, family 4, subfamily M, member 1	206					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|endometrium(1)|large_intestine(4)|lung(32)|prostate(1)|skin(2)	42	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		GTGGTCTGATCTCTGTGGTGT	0.473000													21	333					1.50039e-11	1.69856e-11	1	1	0
SLC38A11	151258	broad.mit.edu	37	2	165796058	165796058	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-A4IG-01A-11D-A25Y-08	TCGA-BA-A4IG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	200d5ad1-bd1f-4068-a4e4-4b6a3aaaf92d	df122b02-6d09-4441-af8a-cae70fd20fff	g.chr2:165796058C>G	ENST00000303735.4	-	4	535	c.205G>C	c.(205-207)Gaa>Caa	p.E69Q	SLC38A11_ENST00000409149.3_Missense_Mutation_p.E91Q|SLC38A11_ENST00000409058.1_Missense_Mutation_p.E122Q|SLC38A11_ENST00000409662.1_Missense_Mutation_p.E91Q	NM_173512.2	NP_775783.1	Q08AI6	S38AB_HUMAN	solute carrier family 38, member 11	91					amino acid transport|sodium ion transport	integral to membrane				endometrium(2)|large_intestine(4)|lung(8)|ovary(1)	15						AACACGTTTTCAGGATCAACT	0.328000													6	60					0	0	1	0	0
ANKLE2	23141	broad.mit.edu	37	12	133327347	133327347	+	Missense_Mutation	SNP	T	T	A			TCGA-BA-A4IG-01A-11D-A25Y-08	TCGA-BA-A4IG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	200d5ad1-bd1f-4068-a4e4-4b6a3aaaf92d	df122b02-6d09-4441-af8a-cae70fd20fff	g.chr12:133327347T>A	ENST00000539605.1	-	2	7227	c.543A>T	c.(541-543)agA>agT	p.R181S	ANKLE2_ENST00000337516.5_Missense_Mutation_p.R243S|ANKLE2_ENST00000357997.5_Missense_Mutation_p.R243S			Q86XL3	ANKL2_HUMAN	ankyrin repeat and LEM domain containing 2	243						cytoplasm|integral to membrane|nuclear envelope				NS(2)|autonomic_ganglia(1)|breast(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(4)|lung(20)|ovary(1)|urinary_tract(2)	45	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0176)|Lung NSC(355;0.204)		OV - Ovarian serous cystadenocarcinoma(86;2.3e-08)|Epithelial(86;1.56e-07)|all cancers(50;4.94e-06)		CAGCGTCTTCTCTGGTAGAAA	0.388000													33	88					0	0	1	0	0
VNN1	8876	broad.mit.edu	37	6	133014383	133014383	+	Silent	SNP	G	G	T			TCGA-BA-A4IG-01A-11D-A25Y-08	TCGA-BA-A4IG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	200d5ad1-bd1f-4068-a4e4-4b6a3aaaf92d	df122b02-6d09-4441-af8a-cae70fd20fff	g.chr6:133014383G>T	ENST00000367928.4	-	4	619	c.606C>A	c.(604-606)acC>acA	p.T202T		NM_004666.2	NP_004657.2	O95497	VNN1_HUMAN	vanin 1	202	CN hydrolase.				acute inflammatory response|anti-apoptosis|cell-cell adhesion|cellular component movement|chronic inflammatory response|innate immune response|pantothenate metabolic process|positive regulation of T cell differentiation in thymus|response to oxidative stress	anchored to membrane|integral to membrane|plasma membrane	GPI anchor binding|pantetheine hydrolase activity			NS(2)|endometrium(3)|kidney(2)|large_intestine(8)|lung(10)|ovary(4)|prostate(1)|upper_aerodigestive_tract(1)	31	Breast(56;0.135)			OV - Ovarian serous cystadenocarcinoma(155;0.0027)|GBM - Glioblastoma multiforme(226;0.0189)		AACTTCCAAAGGTGGTATTGA	0.383000													5	79					3.59834e-05	3.85536e-05	1	1	0
GBP7	388646	broad.mit.edu	37	1	89607325	89607325	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-A4IG-01A-11D-A25Y-08	TCGA-BA-A4IG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	200d5ad1-bd1f-4068-a4e4-4b6a3aaaf92d	df122b02-6d09-4441-af8a-cae70fd20fff	g.chr1:89607325C>T	ENST00000294671.2	-	9	1510	c.1372G>A	c.(1372-1374)Gag>Aag	p.E458K		NM_207398.2	NP_997281.2	Q8N8V2	GBP7_HUMAN	guanylate binding protein 7	458						integral to membrane	GTP binding|GTPase activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(2)|large_intestine(9)|lung(5)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	27		Lung NSC(277;0.0908)		all cancers(265;0.00835)|Epithelial(280;0.0322)		TGGAGGACCTCGTCTGCCTGA	0.488000													10	61					0	0	1	0	0
TMEM39A	55254	broad.mit.edu	37	3	119153706	119153706	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-A4IG-01A-11D-A25Y-08	TCGA-BA-A4IG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	200d5ad1-bd1f-4068-a4e4-4b6a3aaaf92d	df122b02-6d09-4441-af8a-cae70fd20fff	g.chr3:119153706G>C	ENST00000319172.5	-	8	1556	c.1136C>G	c.(1135-1137)cCt>cGt	p.P379R		NM_018266.1	NP_060736.1	Q9NV64	TM39A_HUMAN	transmembrane protein 39A	379						integral to membrane				NS(1)|breast(1)|endometrium(1)|large_intestine(2)|lung(5)|ovary(2)|skin(1)	13				GBM - Glioblastoma multiforme(114;0.244)		CACCCCTTGAGGCCATATTGT	0.453000													22	101					0	0	1	0	0
RNF213	57674	broad.mit.edu	37	17	78293223	78293223	+	Silent	SNP	A	A	T			TCGA-BA-A4IG-01A-11D-A25Y-08	TCGA-BA-A4IG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	200d5ad1-bd1f-4068-a4e4-4b6a3aaaf92d	df122b02-6d09-4441-af8a-cae70fd20fff	g.chr17:78293223A>T	ENST00000319921.4	+	17	3276	c.3135A>T	c.(3133-3135)tcA>tcT	p.S1045S	RNF213_ENST00000456466.1_Intron|RNF213_ENST00000508628.2_Intron|RNF213_ENST00000582970.1_Intron	NM_020954.3	NP_066005.2	Q9HCF4	ALO17_HUMAN	ring finger protein 213	0										NS(1)|breast(7)|central_nervous_system(1)|cervix(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(23)|lung(36)|ovary(11)|pancreas(2)|prostate(4)|skin(3)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	130	all_neural(118;0.0538)		BRCA - Breast invasive adenocarcinoma(99;0.0252)|OV - Ovarian serous cystadenocarcinoma(97;0.057)			CCGCTAACTCAGAGATTGGGA	0.587000													12	79					0	0	1	0	0
ZNF44	51710	broad.mit.edu	37	19	12384064	12384064	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-A4IG-01A-11D-A25Y-08	TCGA-BA-A4IG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	200d5ad1-bd1f-4068-a4e4-4b6a3aaaf92d	df122b02-6d09-4441-af8a-cae70fd20fff	g.chr19:12384064G>C	ENST00000356109.5	-	5	1268	c.1150C>G	c.(1150-1152)Cct>Gct	p.P384A	ZNF44_ENST00000355684.5_Missense_Mutation_p.P336A	NM_001164276.1	NP_001157748.1	P15621	ZNF44_HUMAN	zinc finger protein 44	384					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|microtubule cytoskeleton|nucleus	DNA binding|protein binding|zinc ion binding			ovary(1)	1		Renal(1328;0.157)		GBM - Glioblastoma multiforme(1328;0.0164)|Lung(535;0.179)		CATTTATGAGGTCCATCTCCA	0.408000													40	146					0	0	1	0	0
PARP14	54625	broad.mit.edu	37	3	122420291	122420291	+	Missense_Mutation	SNP	G	G	A	rs76716529		TCGA-BA-A4IG-01A-11D-A25Y-08	TCGA-BA-A4IG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	200d5ad1-bd1f-4068-a4e4-4b6a3aaaf92d	df122b02-6d09-4441-af8a-cae70fd20fff	g.chr3:122420291G>A	ENST00000474629.2	+	6	3156	c.2890G>A	c.(2890-2892)Gag>Aag	p.E964K		NM_017554.2	NP_060024.2	Q460N5	PAR14_HUMAN	poly (ADP-ribose) polymerase family, member 14	964	Macro 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	NAD+ ADP-ribosyltransferase activity			NS(2)|breast(5)|cervix(2)|endometrium(7)|kidney(5)|large_intestine(8)|lung(14)|ovary(2)|pancreas(1)|prostate(2)|skin(1)|urinary_tract(1)	50				GBM - Glioblastoma multiforme(114;0.0531)		GGATGTATCTGAGAAGACTGT	0.493000													13	51					0	0	1	0	0
ATAD2	29028	broad.mit.edu	37	8	124346146	124346146	+	Silent	SNP	C	C	T	rs147456124	byFrequency	TCGA-BA-A4IG-01A-11D-A25Y-08	TCGA-BA-A4IG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	200d5ad1-bd1f-4068-a4e4-4b6a3aaaf92d	df122b02-6d09-4441-af8a-cae70fd20fff	g.chr8:124346146C>T	ENST00000287394.5	-	24	3557	c.3450G>A	c.(3448-3450)ccG>ccA	p.P1150P	ATAD2_ENST00000521903.1_Silent_p.P468P	NM_014109.3	NP_054828.2	Q6PL18	ATAD2_HUMAN	ATPase family, AAA domain containing 2	1150					regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrion|nucleus	ATP binding|ATPase activity			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(12)|lung(16)|ovary(3)|prostate(3)|skin(1)|urinary_tract(2)	48	Lung NSC(37;1.25e-09)|Ovarian(258;0.00838)		STAD - Stomach adenocarcinoma(47;0.00288)			CAGGAGTACTCGGTGTCTTTA	0.388000													44	67					0	0	1	0	0
MME	4311	broad.mit.edu	37	3	154802000	154802000	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-A4IG-01A-11D-A25Y-08	TCGA-BA-A4IG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	200d5ad1-bd1f-4068-a4e4-4b6a3aaaf92d	df122b02-6d09-4441-af8a-cae70fd20fff	g.chr3:154802000C>T	ENST00000460393.1	+	2	164	c.44C>T	c.(43-45)aCt>aTt	p.T15I	MME_ENST00000493237.1_Missense_Mutation_p.T15I|MME_ENST00000462745.1_Missense_Mutation_p.T15I|MME_ENST00000360490.2_Missense_Mutation_p.T15I|MME_ENST00000492661.1_Missense_Mutation_p.T15I|MME_ENST00000382989.3_Missense_Mutation_p.T15I	NM_000902.3|NM_007287.2	NP_000893.2|NP_009218.2	P08473	NEP_HUMAN	membrane metallo-endopeptidase	15					cell-cell signaling|proteolysis	integral to plasma membrane	metal ion binding|metalloendopeptidase activity|protein binding			central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(31)|ovary(3)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	64		all_neural(597;0.00391)|Myeloproliferative disorder(1037;0.0122)	LUSC - Lung squamous cell carcinoma(72;0.114)|Lung(72;0.135)		Candoxatril(DB00616)	GATATCAACACTCCAAAGCCA	0.393000													11	202					0	0	1	0	0
DCT	1638	broad.mit.edu	37	13	95092186	95092186	+	Missense_Mutation	SNP	T	T	C			TCGA-BA-A4IG-01A-11D-A25Y-08	TCGA-BA-A4IG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	200d5ad1-bd1f-4068-a4e4-4b6a3aaaf92d	df122b02-6d09-4441-af8a-cae70fd20fff	g.chr13:95092186T>C	ENST00000377028.5	-	8	1939	c.1526A>G	c.(1525-1527)cAt>cGt	p.H509R	DCT_ENST00000446125.1_Missense_Mutation_p.H542R	NM_001922.3	NP_001913.2	P40126	TYRP2_HUMAN	dopachrome tautomerase	509					epidermis development|melanin biosynthetic process from tyrosine	cytosol|integral to membrane|melanosome membrane|microsome	copper ion binding|dopachrome isomerase activity|oxidoreductase activity			NS(1)|breast(1)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(14)|liver(1)|lung(16)|ovary(2)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	50	all_neural(89;0.0684)|Medulloblastoma(90;0.163)	all_cancers(2;3.71e-42)|all_epithelial(2;3.76e-31)|all_lung(2;5.16e-14)|Lung NSC(4;1.33e-13)|Breast(118;0.0013)|Hepatocellular(115;0.00886)|Renal(2;0.00988)		COAD - Colon adenocarcinoma(199;7.07e-05)|GBM - Glioblastoma multiforme(99;0.000472)		GCTGCTTAAATGTGTCTCCAT	0.453000													25	60					0	0	1	0	0
SURF2	6835	broad.mit.edu	37	9	136227943	136227943	+	Silent	SNP	C	C	G			TCGA-BA-A4IG-01A-11D-A25Y-08	TCGA-BA-A4IG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	200d5ad1-bd1f-4068-a4e4-4b6a3aaaf92d	df122b02-6d09-4441-af8a-cae70fd20fff	g.chr9:136227943C>G	ENST00000371964.4	+	6	740	c.699C>G	c.(697-699)ggC>ggG	p.G233G		NM_017503.3	NP_059973.3	Q15527	SURF2_HUMAN	surfeit 2	233							protein binding			breast(1)|large_intestine(1)|lung(4)	6				OV - Ovarian serous cystadenocarcinoma(145;4.87e-07)|Epithelial(140;4.02e-06)|all cancers(34;3.71e-05)		AGCAGTTGGGCTCGTTGAAAA	0.493000													10	162					0	0	1	0	0
TREM2	54209	broad.mit.edu	37	6	41130791	41130791	+	Silent	SNP	G	G	C			TCGA-BA-A4IG-01A-11D-A25Y-08	TCGA-BA-A4IG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	200d5ad1-bd1f-4068-a4e4-4b6a3aaaf92d	df122b02-6d09-4441-af8a-cae70fd20fff	g.chr6:41130791G>C	ENST00000373113.3	-	1	123	c.30C>G	c.(28-30)ctC>ctG	p.L10L	TREM2_ENST00000373122.4_Silent_p.L10L|TREM2_ENST00000338469.3_Silent_p.L10L	NM_018965.2	NP_061838.1	Q9NZC2	TREM2_HUMAN	triggering receptor expressed on myeloid cells 2	10					axon guidance|humoral immune response	extracellular region|integral to membrane|plasma membrane	receptor activity			breast(1)|endometrium(2)|large_intestine(4)|lung(2)|ovary(1)|pancreas(1)	11	Ovarian(28;0.0418)|Colorectal(47;0.196)					CTGTGACAAAGAGTAAGATGA	0.582000													7	25					0	0	1	0	0
AGO4	192670	broad.mit.edu	37	1	36282503	36282503	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BA-A4IG-01A-11D-A25Y-08	TCGA-BA-A4IG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	200d5ad1-bd1f-4068-a4e4-4b6a3aaaf92d	df122b02-6d09-4441-af8a-cae70fd20fff	g.chr1:36282503C>T	ENST00000373210.3	+	2	285	c.40C>T	c.(40-42)Cag>Tag	p.Q14*		NM_017629.3	NP_060099.2			argonaute RISC catalytic component 4																		TAGCCTGTTTCAGCCACCTCG	0.358000													12	97					0	0	1	0	0
ANGPTL7	10218	broad.mit.edu	37	1	11254561	11254561	+	Missense_Mutation	SNP	T	T	A			TCGA-BA-A4IG-01A-11D-A25Y-08	TCGA-BA-A4IG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	200d5ad1-bd1f-4068-a4e4-4b6a3aaaf92d	df122b02-6d09-4441-af8a-cae70fd20fff	g.chr1:11254561T>A	ENST00000376819.3	+	4	955	c.716T>A	c.(715-717)gTt>gAt	p.V239D	ANGPTL7_ENST00000476934.1_Intron|MTOR_ENST00000361445.4_Intron	NM_021146.2	NP_066969.1	O43827	ANGL7_HUMAN	angiopoietin-like 7	239	Fibrinogen C-terminal.				response to oxidative stress|signal transduction	extracellular region	receptor binding			endometrium(2)|kidney(1)|large_intestine(1)|lung(3)|skin(2)|stomach(1)	10	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.000818)|all_lung(284;0.00105)|Colorectal(325;0.0062)|Breast(348;0.0139)|Hepatocellular(190;0.0305)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;1.39e-06)|COAD - Colon adenocarcinoma(227;0.000244)|BRCA - Breast invasive adenocarcinoma(304;0.000294)|Kidney(185;0.000728)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0487)		AGCCACTTTGTTTTGGGCAAT	0.527000													13	166					0	0	1	0	0
NTN4	59277	broad.mit.edu	37	12	96107023	96107023	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-A4IG-01A-11D-A25Y-08	TCGA-BA-A4IG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	200d5ad1-bd1f-4068-a4e4-4b6a3aaaf92d	df122b02-6d09-4441-af8a-cae70fd20fff	g.chr12:96107023C>T	ENST00000343702.4	-	4	1406	c.958G>A	c.(958-960)Gat>Aat	p.D320N	NTN4_ENST00000538383.1_Missense_Mutation_p.D283N|NTN4_ENST00000344911.4_Missense_Mutation_p.D283N|NTN4_ENST00000553059.1_Missense_Mutation_p.D320N	NM_021229.3	NP_067052.2	Q9HB63	NET4_HUMAN	netrin 4	320	Laminin EGF-like 1.				axon guidance	basement membrane|plasma membrane				NS(2)|breast(1)|kidney(1)|large_intestine(7)|lung(8)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	25						GTTTTGCCATCAGCTGCCTCC	0.517000													10	55					0	0	1	0	0
CNGB3	54714	broad.mit.edu	37	8	87641148	87641148	+	Splice_Site	SNP	T	T	C			TCGA-BA-A4IG-01A-11D-A25Y-08	TCGA-BA-A4IG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	200d5ad1-bd1f-4068-a4e4-4b6a3aaaf92d	df122b02-6d09-4441-af8a-cae70fd20fff	g.chr8:87641148T>C	ENST00000320005.5	-	12	1526	c.1480_splice	c.e12+1	p.L493_splice		NM_019098.4	NP_061971.3	Q9NQW8	CNGB3_HUMAN	cyclic nucleotide gated channel beta 3	493					signal transduction|visual perception	integral to membrane	cGMP binding			NS(1)|breast(2)|endometrium(4)|kidney(6)|large_intestine(15)|lung(44)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	80						CATGCTTACCTAGCATTCTTT	0.383000													14	198					0	0	1	0	0
CDC5L	988	broad.mit.edu	37	6	44413455	44413455	+	Missense_Mutation	SNP	A	A	T			TCGA-BA-A4IG-01A-11D-A25Y-08	TCGA-BA-A4IG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	200d5ad1-bd1f-4068-a4e4-4b6a3aaaf92d	df122b02-6d09-4441-af8a-cae70fd20fff	g.chr6:44413455A>T	ENST00000371477.3	+	15	2454	c.2155A>T	c.(2155-2157)Att>Ttt	p.I719F		NM_001253.3	NP_001244.1	Q99459	CDC5L_HUMAN	cell division cycle 5-like	719	Interaction with PLRG1.				cell cycle|regulation of transcription, DNA-dependent|transcription, DNA-dependent	catalytic step 2 spliceosome|cytoplasm|nuclear speck|nucleolus	DNA binding|RNA binding			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(3)|lung(14)|ovary(1)|skin(4)	29	all_lung(25;0.00433)|Ovarian(13;0.0273)|all_hematologic(164;0.208)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)			GAAGATGAAAATTTTGCTTGG	0.463000													18	65					0	0	1	0	0
CLEC18B	497190	broad.mit.edu	37	16	74447558	74447558	+	Nonsense_Mutation	SNP	G	G	C			TCGA-BA-A4IG-01A-11D-A25Y-08	TCGA-BA-A4IG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	200d5ad1-bd1f-4068-a4e4-4b6a3aaaf92d	df122b02-6d09-4441-af8a-cae70fd20fff	g.chr16:74447558G>C	ENST00000339953.5	-	4	594	c.473C>G	c.(472-474)tCa>tGa	p.S158*		NM_001011880.2	NP_001011880.2	Q6UXF7	CL18B_HUMAN	C-type lectin domain family 18, member B	158	SCP.					extracellular region	sugar binding			endometrium(3)|kidney(9)|large_intestine(3)|lung(7)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	27						CAGCTGGCTTGAGGTGGCCCA	0.602000													23	147					0	0	1	0	0
NBPF10	100132406	broad.mit.edu	37	1	145367739	145367739	+	Silent	SNP	A	A	G	rs146714035	by1000genomes	TCGA-BA-A4IG-01A-11D-A25Y-08	TCGA-BA-A4IG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	200d5ad1-bd1f-4068-a4e4-4b6a3aaaf92d	df122b02-6d09-4441-af8a-cae70fd20fff	g.chr1:145367739A>G	ENST00000342960.5	+	83	10370	c.10335A>G	c.(10333-10335)aaA>aaG	p.K3445K	NBPF10_ENST00000369339.2_Intron|NBPF10_ENST00000369338.1_Intron	NM_001039703.4	NP_001034792.4	A6NDV3	A6NDV3_HUMAN	neuroblastoma breakpoint family, member 10	3445								p.K3445K(4)		NS(3)|breast(1)|central_nervous_system(3)|endometrium(12)|kidney(23)|lung(15)|ovary(1)|prostate(7)|skin(6)|urinary_tract(2)	73	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		ggaaggggaaaaaaagaaggg	0.413000													6	111					0	0	1	0	0
NUBP2	10101	broad.mit.edu	37	16	1838664	1838664	+	Silent	SNP	C	C	A	rs147565674		TCGA-BA-A4IG-01A-11D-A25Y-08	TCGA-BA-A4IG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	200d5ad1-bd1f-4068-a4e4-4b6a3aaaf92d	df122b02-6d09-4441-af8a-cae70fd20fff	g.chr16:1838664C>A	ENST00000262302.9	+	7	885	c.765C>A	c.(763-765)ctC>ctA	p.L255L	NUBP2_ENST00000543305.1_Silent_p.L114L|NUBP2_ENST00000565987.1_Silent_p.L195L|NUBP2_ENST00000568706.1_Silent_p.L114L	NM_012225.2	NP_036357.1	Q9Y5Y2	NUBP2_HUMAN	nucleotide binding protein 2	255						microtubule organizing center|nucleus	4 iron, 4 sulfur cluster binding|ATP binding|metal ion binding|protein binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|lung(2)|skin(1)|upper_aerodigestive_tract(1)	6						TCGCTGCACTCACCTCCATAG	0.667000													7	21					2.0095e-06	2.20555e-06	1	1	0
RUSC2	9853	broad.mit.edu	37	9	35555103	35555103	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-A4IG-01A-11D-A25Y-08	TCGA-BA-A4IG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	200d5ad1-bd1f-4068-a4e4-4b6a3aaaf92d	df122b02-6d09-4441-af8a-cae70fd20fff	g.chr9:35555103G>C	ENST00000455600.1	+	3	2630	c.2061G>C	c.(2059-2061)caG>caC	p.Q687H		NM_001135999.1	NP_001129471.1	Q8N2Y8	RUSC2_HUMAN	RUN and SH3 domain containing 2	687						cytosol				NS(1)|breast(3)|endometrium(4)|kidney(1)|large_intestine(9)|lung(4)|ovary(2)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	32			Lung(28;0.000837)|LUSC - Lung squamous cell carcinoma(32;0.00109)|STAD - Stomach adenocarcinoma(86;0.194)			GCAAGGAACAGAGGCCAACCA	0.582000													32	89					0	0	1	0	0
OCM	654231	broad.mit.edu	37	7	5922148	5922148	+	Missense_Mutation	SNP	A	A	T			TCGA-BA-A4IG-01A-11D-A25Y-08	TCGA-BA-A4IG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	200d5ad1-bd1f-4068-a4e4-4b6a3aaaf92d	df122b02-6d09-4441-af8a-cae70fd20fff	g.chr7:5922148A>T	ENST00000242104.5	+	2	178	c.86A>T	c.(85-87)aAa>aTa	p.K29I	OCM_ENST00000416608.1_Missense_Mutation_p.K29I	NM_001097622.1	NP_001091091.1	P0CE72	ONCO_HUMAN	oncomodulin	29							calcium ion binding			endometrium(1)|large_intestine(3)|lung(2)	6		Ovarian(82;0.0694)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0978)|OV - Ovarian serous cystadenocarcinoma(56;2.11e-14)		GAACCCCAAAAATTCTTCCAG	0.453000													34	94					0	0	1	0	0
HNRNPA3	220988	broad.mit.edu	37	2	178082558	178082558	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-A4IG-01A-11D-A25Y-08	TCGA-BA-A4IG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	200d5ad1-bd1f-4068-a4e4-4b6a3aaaf92d	df122b02-6d09-4441-af8a-cae70fd20fff	g.chr2:178082558G>A	ENST00000411529.2	+	8	931	c.880G>A	c.(880-882)Gga>Aga	p.G294R	HNRNPA3_ENST00000435711.1_Missense_Mutation_p.G316R|HNRNPA3_ENST00000392524.2_Missense_Mutation_p.G316R	NM_194247.2	NP_919223.1	P51991	ROA3_HUMAN	heterogeneous nuclear ribonucleoprotein A3	316	Gly-rich.					catalytic step 2 spliceosome|nucleolus|nucleoplasm	nucleotide binding|protein binding|RNA binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(3)|ovary(2)|urinary_tract(1)	16						CAATGAAGGAGGAAATTTTGG	0.403000													34	125					0	0	1	0	0
APP	351	broad.mit.edu	37	21	27269970	27269970	+	Missense_Mutation	SNP	T	T	C			TCGA-BA-A4IG-01A-11D-A25Y-08	TCGA-BA-A4IG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	200d5ad1-bd1f-4068-a4e4-4b6a3aaaf92d	df122b02-6d09-4441-af8a-cae70fd20fff	g.chr21:27269970T>C	ENST00000358918.3	-	15	2124	c.1925A>G	c.(1924-1926)aAt>aGt	p.N642S	APP_ENST00000354192.3_Missense_Mutation_p.N529S|APP_ENST00000359726.3_Missense_Mutation_p.N604S|APP_ENST00000348990.5_Missense_Mutation_p.N585S|APP_ENST00000448388.2_Missense_Mutation_p.N550S|APP_ENST00000357903.3_Missense_Mutation_p.N641S|APP_ENST00000346798.3_Missense_Mutation_p.N660S|APP_ENST00000439274.2_Missense_Mutation_p.N604S|APP_ENST00000440126.3_Missense_Mutation_p.N636S	NM_001204301.1|NM_001204302.1	NP_001191230.1|NP_001191231.1	P05067	A4_HUMAN	amyloid beta (A4) precursor protein	660					adult locomotory behavior|axon cargo transport|axon midline choice point recognition|cell adhesion|cellular copper ion homeostasis|collateral sprouting in absence of injury|dendrite development|endocytosis|extracellular matrix organization|G2 phase of mitotic cell cycle|innate immune response|ionotropic glutamate receptor signaling pathway|mating behavior|mRNA polyadenylation|neuron apoptosis|neuron remodeling|Notch signaling pathway|platelet activation|platelet degranulation|positive regulation of mitotic cell cycle|protein phosphorylation|regulation of epidermal growth factor receptor activity|regulation of multicellular organism growth|regulation of synapse structure and activity|regulation of translation|visual learning	axon|cell surface|coated pit|dendritic shaft|dendritic spine|extracellular region|Golgi apparatus|integral to plasma membrane|platelet alpha granule lumen	acetylcholine receptor binding|DNA binding|heparin binding|identical protein binding|metal ion binding|protein binding|PTB domain binding|serine-type endopeptidase inhibitor activity			endometrium(5)|large_intestine(3)|lung(11)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	22		Breast(209;0.00295)				CGTCTTGATATTTGTCAACCC	0.348000													40	117					0	0	1	0	0
CCDC39	339829	broad.mit.edu	37	3	180337659	180337659	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-A4IG-01A-11D-A25Y-08	TCGA-BA-A4IG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	200d5ad1-bd1f-4068-a4e4-4b6a3aaaf92d	df122b02-6d09-4441-af8a-cae70fd20fff	g.chr3:180337659G>C	ENST00000442201.2	-	15	2217	c.2098C>G	c.(2098-2100)Caa>Gaa	p.Q700E	CCDC39_ENST00000273654.4_Intron	NM_181426.1	NP_852091.1	Q9UFE4	CCD39_HUMAN	coiled-coil domain containing 39	700					axonemal dynein complex assembly|ciliary cell motility|cilium movement involved in determination of left/right asymmetry|flagellar cell motility	cilium axoneme|cytoplasm|cytoskeleton				NS(1)|breast(1)|endometrium(4)|large_intestine(9)|lung(22)|ovary(6)|prostate(2)	45	all_cancers(143;9.31e-15)|Ovarian(172;0.0212)		OV - Ovarian serous cystadenocarcinoma(80;5.62e-23)|GBM - Glioblastoma multiforme(14;0.000558)			TTCAGCACTTGAAGGGTATTT	0.348000													10	34					0	0	1	0	0
ALPK3	57538	broad.mit.edu	37	15	85399943	85399943	+	Silent	SNP	G	G	A			TCGA-BA-A4IG-01A-11D-A25Y-08	TCGA-BA-A4IG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	200d5ad1-bd1f-4068-a4e4-4b6a3aaaf92d	df122b02-6d09-4441-af8a-cae70fd20fff	g.chr15:85399943G>A	ENST00000258888.5	+	6	2747	c.2580G>A	c.(2578-2580)caG>caA	p.Q860Q		NM_020778.4	NP_065829.3	Q96L96	ALPK3_HUMAN	alpha-kinase 3	860					heart development	nucleus	ATP binding|protein serine/threonine kinase activity			NS(3)|breast(2)|central_nervous_system(2)|endometrium(12)|kidney(4)|large_intestine(9)|lung(27)|ovary(3)|prostate(5)|skin(8)|stomach(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	81			BRCA - Breast invasive adenocarcinoma(143;0.0587)			GGAGTGCACAGAAGGGCATGA	0.542000													5	46					0	0	1	0	0
SLC2A3	6515	broad.mit.edu	37	12	8077033	8077033	+	Silent	SNP	C	C	G			TCGA-BA-A4IG-01A-11D-A25Y-08	TCGA-BA-A4IG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	200d5ad1-bd1f-4068-a4e4-4b6a3aaaf92d	df122b02-6d09-4441-af8a-cae70fd20fff	g.chr12:8077033C>G	ENST00000075120.7	-	8	1281	c.1041G>C	c.(1039-1041)acG>acC	p.T347T		NM_006931.2	NP_008862.1	P11169	GTR3_HUMAN	solute carrier family 2 (facilitated glucose transporter), member 3	347					carbohydrate metabolic process|water-soluble vitamin metabolic process	integral to membrane|plasma membrane	D-glucose transmembrane transporter activity|dehydroascorbic acid transporter activity			central_nervous_system(1)|cervix(2)|endometrium(1)|kidney(3)|large_intestine(2)|lung(14)|ovary(3)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	30				Kidney(36;0.0866)		CAGTCATGAGCGTGGAACAAA	0.438000													12	59					0	0	1	0	0
LINC00264	645528	broad.mit.edu	37	10	26880266	26880266	+	RNA	SNP	G	G	A	rs138111133	by1000genomes	TCGA-BA-A4IG-01A-11D-A25Y-08	TCGA-BA-A4IG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	200d5ad1-bd1f-4068-a4e4-4b6a3aaaf92d	df122b02-6d09-4441-af8a-cae70fd20fff	g.chr10:26880266G>A	ENST00000412114.1	+	0	501					NR_026793.1																						ACCAAGCCCAGTGGACAGATG	0.443000													6	43					0	0	1	0	0
PBDC1	51260	broad.mit.edu	37	X	75395436	75395436	+	Silent	SNP	A	A	G			TCGA-BA-A4IG-01A-11D-A25Y-08	TCGA-BA-A4IG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	200d5ad1-bd1f-4068-a4e4-4b6a3aaaf92d	df122b02-6d09-4441-af8a-cae70fd20fff	g.chrX:75395436A>G	ENST00000373358.3	+	4	488	c.285A>G	c.(283-285)gaA>gaG	p.E95E	PBDC1_ENST00000373357.3_Silent_p.E95E	NM_016500.3	NP_057584.2			polysaccharide biosynthesis domain containing 1																		TCAAGTCAGAATCAGCCAAAG	0.328000													13	17					0	0	1	0	0
ARHGEF3	50650	broad.mit.edu	37	3	56766330	56766330	+	Silent	SNP	G	G	A			TCGA-BA-A4IG-01A-11D-A25Y-08	TCGA-BA-A4IG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	200d5ad1-bd1f-4068-a4e4-4b6a3aaaf92d	df122b02-6d09-4441-af8a-cae70fd20fff	g.chr3:56766330G>A	ENST00000413728.2	-	9	1725	c.1182C>T	c.(1180-1182)gaC>gaT	p.D394D	ARHGEF3_ENST00000496106.1_Silent_p.D394D|ARHGEF3_ENST00000296315.3_Silent_p.D388D|ARHGEF3_ENST00000338458.4_Silent_p.D420D|ARHGEF3_ENST00000497267.1_Silent_p.D359D|ARHGEF3_ENST00000495373.1_Silent_p.D388D	NM_001128616.1	NP_001122088.1	Q9NR81	ARHG3_HUMAN	Rho guanine nucleotide exchange factor (GEF) 3	388	PH.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|Rho protein signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity			cervix(1)|endometrium(3)|kidney(3)|large_intestine(4)|lung(11)|ovary(1)|prostate(1)|urinary_tract(1)	25				KIRC - Kidney renal clear cell carcinoma(284;0.0161)|Kidney(284;0.019)|OV - Ovarian serous cystadenocarcinoma(275;0.193)		CATCCTGGAGGTCTTCCAGCA	0.542000													26	87					0	0	1	0	0
GINS2	51659	broad.mit.edu	37	16	85721167	85721167	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-A4IG-01A-11D-A25Y-08	TCGA-BA-A4IG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	200d5ad1-bd1f-4068-a4e4-4b6a3aaaf92d	df122b02-6d09-4441-af8a-cae70fd20fff	g.chr16:85721167G>C	ENST00000253462.3	-	2	204	c.104C>G	c.(103-105)cCt>cGt	p.P35R		NM_016095.2	NP_057179.1	Q9Y248	PSF2_HUMAN	GINS complex subunit 2 (Psf2 homolog)	35					DNA strand elongation involved in DNA replication|S phase of mitotic cell cycle	nucleoplasm	protein binding			endometrium(2)|large_intestine(2)|lung(2)	6						AGGGTTAAAAGGCCCCAGGTC	0.468000													7	55					0	0	1	0	0
HECTD4	283450	broad.mit.edu	37	12	112673334	112673334	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-A4IG-01A-11D-A25Y-08	TCGA-BA-A4IG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	200d5ad1-bd1f-4068-a4e4-4b6a3aaaf92d	df122b02-6d09-4441-af8a-cae70fd20fff	g.chr12:112673334G>A	ENST00000550722.1	-	36	5656	c.5261C>T	c.(5260-5262)gCa>gTa	p.A1754V	HECTD4_ENST00000377560.5_Missense_Mutation_p.A1728V|HECTD4_ENST00000430131.2_Missense_Mutation_p.A1478V	NM_001109662.3	NP_001103132.3			HECT domain containing E3 ubiquitin protein ligase 4																		TGCCAGCTTTGCTAAGAGCAG	0.567000													16	43					0	0	1	0	0
RANBP2	5903	broad.mit.edu	37	2	109382596	109382596	+	Silent	SNP	A	A	G			TCGA-BA-A4IG-01A-11D-A25Y-08	TCGA-BA-A4IG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	200d5ad1-bd1f-4068-a4e4-4b6a3aaaf92d	df122b02-6d09-4441-af8a-cae70fd20fff	g.chr2:109382596A>G	ENST00000283195.6	+	20	5727	c.5601A>G	c.(5599-5601)gaA>gaG	p.E1867E		NM_006267.4	NP_006258.3	P49792	RBP2_HUMAN	RAN binding protein 2	1867					carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA transport|protein folding|protein import into nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear pore	peptidyl-prolyl cis-trans isomerase activity|Ran GTPase binding|zinc ion binding		RANBP2/ALK(34)	NS(1)|biliary_tract(1)|breast(3)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(21)|large_intestine(19)|lung(51)|pancreas(1)|prostate(8)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(1)	129						TGGATCAAGAAAATTCACCTT	0.358000													85	203					0	0	1	0	0
SRSF6	6431	broad.mit.edu	37	20	42088499	42088499	+	Missense_Mutation	SNP	A	A	T			TCGA-BA-A4IG-01A-11D-A25Y-08	TCGA-BA-A4IG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	200d5ad1-bd1f-4068-a4e4-4b6a3aaaf92d	df122b02-6d09-4441-af8a-cae70fd20fff	g.chr20:42088499A>T	ENST00000244020.3	+	3	451	c.345A>T	c.(343-345)gaA>gaT	p.E115D		NM_006275.5	NP_006266.2	Q13247	SRSF6_HUMAN	serine/arginine-rich splicing factor 6	115	RRM 2.				mRNA 3'-end processing|mRNA export from nucleus|mRNA splice site selection|termination of RNA polymerase II transcription	nucleoplasm	nucleotide binding|protein binding|RNA binding			haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|upper_aerodigestive_tract(2)	5						TTATTGTAGAAAATCTTTCTA	0.378000													39	103					0	0	1	0	0
TLR9	54106	broad.mit.edu	37	3	52263740	52263740	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BA-A4IG-01A-11D-A25Y-08	TCGA-BA-A4IG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	200d5ad1-bd1f-4068-a4e4-4b6a3aaaf92d	df122b02-6d09-4441-af8a-cae70fd20fff	g.chr3:52263740G>A	ENST00000494383.1	-	4	399	c.400C>T	c.(400-402)Cag>Tag	p.Q134*	TWF2_ENST00000305533.5_Silent_p.S273S|TWF2_ENST00000499914.2_Intron|TLR9_ENST00000597542.1_Silent_p.S4S			Q9NR96	TLR9_HUMAN	toll-like receptor 9	0					defense response to bacterium|fibroblast growth factor receptor signaling pathway|I-kappaB phosphorylation|inflammatory response|innate immune response|insulin receptor signaling pathway|maintenance of gastrointestinal epithelium|negative regulation of interleukin-6 production|negative regulation of interleukin-8 production|negative regulation of NF-kappaB transcription factor activity|negative regulation of toll-like receptor signaling pathway|positive regulation of chemokine production|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of interferon-beta production|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-10 production|positive regulation of interleukin-12 production|positive regulation of interleukin-18 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of JUN kinase activity|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of toll-like receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|response to molecule of bacterial origin	apical plasma membrane|basolateral plasma membrane|early phagosome|endoplasmic reticulum membrane|endosome membrane|extracellular region|integral to membrane|lysosome	interleukin-1 receptor binding|siRNA binding|transmembrane receptor activity			endometrium(4)|large_intestine(11)|lung(9)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	30				BRCA - Breast invasive adenocarcinoma(193;2.41e-05)|Kidney(197;0.000537)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)	Chloroquine(DB00608)	TCTTGCAGCTGGAGTAGAGCA	0.622000													13	67					0	0	1	0	0
C1QTNF3	114899	broad.mit.edu	37	5	34033477	34033477	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BA-A4IG-01A-11D-A25Y-08	TCGA-BA-A4IG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	200d5ad1-bd1f-4068-a4e4-4b6a3aaaf92d	df122b02-6d09-4441-af8a-cae70fd20fff	g.chr5:34033477G>A	ENST00000382065.3	-	3	1208	c.502C>T	c.(502-504)Cga>Tga	p.R168*	C1QTNF3_ENST00000231338.7_Nonsense_Mutation_p.R95*	NM_181435.5	NP_852100.3	Q9BXJ4	C1QT3_HUMAN	C1q and tumor necrosis factor related protein 3	95	C1q.					collagen				breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(7)|prostate(3)|stomach(1)|urinary_tract(1)	17	all_lung(31;0.0207)					CGCTCCCCTCGAGGCCCCAGG	0.562000													22	78					0	0	1	0	0
LTK	4058	broad.mit.edu	37	15	41804923	41804923	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-A4IG-01A-11D-A25Y-08	TCGA-BA-A4IG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	200d5ad1-bd1f-4068-a4e4-4b6a3aaaf92d	df122b02-6d09-4441-af8a-cae70fd20fff	g.chr15:41804923G>C	ENST00000263800.6	-	3	437	c.341C>G	c.(340-342)cCg>cGg	p.P114R	LTK_ENST00000355166.5_Missense_Mutation_p.P114R|LTK_ENST00000561619.1_Intron|LTK_ENST00000453182.2_Missense_Mutation_p.P114R	NM_002344.5	NP_002335.2	P29376	LTK_HUMAN	leukocyte receptor tyrosine kinase	114					apoptosis|cell proliferation|phosphatidylinositol 3-kinase cascade|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane|soluble fraction	ATP binding|transmembrane receptor protein tyrosine kinase activity			NS(1)|breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(2)|lung(16)|skin(3)|urinary_tract(1)	26		all_cancers(109;1.89e-19)|all_epithelial(112;2.28e-16)|Lung NSC(122;5.34e-11)|all_lung(180;1.33e-09)|Melanoma(134;0.0179)|Ovarian(310;0.143)|Colorectal(260;0.172)		OV - Ovarian serous cystadenocarcinoma(18;2.1e-17)|GBM - Glioblastoma multiforme(113;1.34e-06)|Colorectal(105;0.0148)|BRCA - Breast invasive adenocarcinoma(123;0.113)		GCCAGGGCCCGGCACGCGCCA	0.662000										TSP Lung(18;0.14)			6	20					0	0	1	0	0
ASPM	259266	broad.mit.edu	37	1	197073087	197073087	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-A4IG-01A-11D-A25Y-08	TCGA-BA-A4IG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	200d5ad1-bd1f-4068-a4e4-4b6a3aaaf92d	df122b02-6d09-4441-af8a-cae70fd20fff	g.chr1:197073087C>G	ENST00000367409.4	-	18	5550	c.5294G>C	c.(5293-5295)aGa>aCa	p.R1765T	ASPM_ENST00000367408.1_Intron|ASPM_ENST00000294732.7_Intron	NM_018136.4	NP_060606.3	Q8IZT6	ASPM_HUMAN	asp (abnormal spindle) homolog, microcephaly associated (Drosophila)	1765	IQ 7.				mitosis	cytoplasm|nucleus	calmodulin binding			breast(6)|central_nervous_system(2)|cervix(2)|endometrium(10)|kidney(9)|large_intestine(28)|liver(1)|lung(87)|ovary(5)|pancreas(2)|prostate(6)|skin(4)|urinary_tract(3)	165						CCGAGCCTTTCTCATTCTGAA	0.358000													48	167					0	0	1	0	0
OR6B2	389090	broad.mit.edu	37	2	240969460	240969460	+	Silent	SNP	C	C	T			TCGA-BA-A4IG-01A-11D-A25Y-08	TCGA-BA-A4IG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	200d5ad1-bd1f-4068-a4e4-4b6a3aaaf92d	df122b02-6d09-4441-af8a-cae70fd20fff	g.chr2:240969460C>T	ENST00000402971.2	-	1	446	c.387G>A	c.(385-387)ccG>ccA	p.P129P		NM_001005853.1	NP_001005853.1	Q6IFH4	OR6B2_HUMAN	olfactory receptor, family 6, subfamily B, member 2	129					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|large_intestine(4)|lung(9)|prostate(1)	15		all_epithelial(40;1.64e-11)|Breast(86;0.000327)|Renal(207;0.00571)|Ovarian(221;0.104)|all_hematologic(139;0.182)|all_lung(227;0.229)|Melanoma(123;0.238)		Epithelial(121;3.4e-29)|all cancers(36;2.08e-27)|OV - Ovarian serous cystadenocarcinoma(60;4.63e-14)|Kidney(56;2.99e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;1.56e-05)|Lung(119;0.00344)|LUSC - Lung squamous cell carcinoma(224;0.0148)		GGTAGCGCAGCGGGTGGCAGA	0.597000													4	31					0	0	1	0	0
ACTL8	81569	broad.mit.edu	37	1	18149579	18149579	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BA-A4IG-01A-11D-A25Y-08	TCGA-BA-A4IG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	200d5ad1-bd1f-4068-a4e4-4b6a3aaaf92d	df122b02-6d09-4441-af8a-cae70fd20fff	g.chr1:18149579C>T	ENST00000375406.1	+	2	292	c.76C>T	c.(76-78)Cag>Tag	p.Q26*		NM_030812.2	NP_110439.2	Q9H568	ACTL8_HUMAN	actin-like 8	26						cytoplasm|cytoskeleton				NS(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(4)|liver(1)|lung(10)|ovary(4)|prostate(1)|skin(1)|urinary_tract(1)	28		Colorectal(325;0.000147)|Renal(390;0.00145)|Breast(348;0.00186)|all_lung(284;0.0054)|Lung NSC(340;0.00566)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0439)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00583)|BRCA - Breast invasive adenocarcinoma(304;6.43e-06)|Kidney(64;0.000258)|KIRC - Kidney renal clear cell carcinoma(64;0.00348)|STAD - Stomach adenocarcinoma(196;0.00652)|READ - Rectum adenocarcinoma(331;0.0698)|Lung(427;0.201)		GAATGAGCCTCAGATGGTCTT	0.597000													21	59					0	0	1	0	0
GRK4	2868	broad.mit.edu	37	4	3031042	3031042	+	Missense_Mutation	SNP	A	A	T			TCGA-BA-A4IG-01A-11D-A25Y-08	TCGA-BA-A4IG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	200d5ad1-bd1f-4068-a4e4-4b6a3aaaf92d	df122b02-6d09-4441-af8a-cae70fd20fff	g.chr4:3031042A>T	ENST00000398052.4	+	12	1518	c.1175A>T	c.(1174-1176)aAa>aTa	p.K392I	GRK4_ENST00000509545.1_3'UTR|GRK4_ENST00000398051.4_Missense_Mutation_p.K360I|GRK4_ENST00000345167.6_Missense_Mutation_p.K360I|GRK4_ENST00000504933.1_Missense_Mutation_p.K392I	NM_182982.2	NP_892027.2	P32298	GRK4_HUMAN	G protein-coupled receptor kinase 4	392	Protein kinase.					cell cortex	ATP binding|G-protein coupled receptor kinase activity|signal transducer activity			lung(1)|upper_aerodigestive_tract(1)	2				UCEC - Uterine corpus endometrioid carcinoma (64;0.168)		TACAAAGAGAAAGTCAAATGG	0.393000													23	53					0	0	1	0	0
ALPK2	115701	broad.mit.edu	37	18	56246469	56246469	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-A4IG-01A-11D-A25Y-08	TCGA-BA-A4IG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	200d5ad1-bd1f-4068-a4e4-4b6a3aaaf92d	df122b02-6d09-4441-af8a-cae70fd20fff	g.chr18:56246469C>G	ENST00000361673.3	-	4	1752	c.1539G>C	c.(1537-1539)gaG>gaC	p.E513D		NM_052947.3	NP_443179.3	Q86TB3	ALPK2_HUMAN	alpha-kinase 2	513							ATP binding|protein serine/threonine kinase activity			NS(1)|central_nervous_system(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(13)|lung(33)|ovary(7)|prostate(1)|skin(10)|upper_aerodigestive_tract(2)	84						CAGCTGCCGTCTCCCAACACT	0.517000											OREG0025011	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	9	158					0	0	1	0	0
NBAS	51594	broad.mit.edu	37	2	15496481	15496481	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-A4IG-01A-11D-A25Y-08	TCGA-BA-A4IG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	200d5ad1-bd1f-4068-a4e4-4b6a3aaaf92d	df122b02-6d09-4441-af8a-cae70fd20fff	g.chr2:15496481G>A	ENST00000281513.5	-	33	3902	c.3877C>T	c.(3877-3879)Cgc>Tgc	p.R1293C	NBAS_ENST00000441750.1_Missense_Mutation_p.R1173C	NM_015909.3	NP_056993.2	A2RRP1	NBAS_HUMAN	neuroblastoma amplified sequence	1293										NS(4)|breast(4)|central_nervous_system(3)|endometrium(6)|kidney(5)|large_intestine(12)|liver(1)|lung(54)|ovary(2)|pancreas(3)|prostate(9)|skin(6)|stomach(3)	112						TCATGGAAGCGAAGTGCCTGC	0.448000													18	42					0	0	1	0	0
PEX11G	92960	broad.mit.edu	37	19	7550722	7550722	+	Splice_Site	SNP	A	A	C			TCGA-BA-A4IG-01A-11D-A25Y-08	TCGA-BA-A4IG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	200d5ad1-bd1f-4068-a4e4-4b6a3aaaf92d	df122b02-6d09-4441-af8a-cae70fd20fff	g.chr19:7550722A>C	ENST00000593942.1	-	4	542		c.e4+1		PEX11G_ENST00000221480.1_Splice_Site			Q96HA9	PX11C_HUMAN	peroxisomal biogenesis factor 11 gamma							integral to membrane|peroxisomal membrane				central_nervous_system(1)|cervix(1)|endometrium(1)|lung(1)|ovary(1)|prostate(1)|skin(1)	7						AAACCCTGTTACCTGTGCCCC	0.512000													7	108					0	0	1	0	0
IGKV5-2	28907	broad.mit.edu	37	2	89197097	89197097	+	RNA	SNP	G	G	A			TCGA-BA-A4IG-01A-11D-A25Y-08	TCGA-BA-A4IG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	200d5ad1-bd1f-4068-a4e4-4b6a3aaaf92d	df122b02-6d09-4441-af8a-cae70fd20fff	g.chr2:89197097G>A	ENST00000390244.2	+	0	205																											AGCCAGCCAAGACATTGATGA	0.463000													36	88					0	0	1	0	0
PLCB1	23236	broad.mit.edu	37	20	8639305	8639305	+	Missense_Mutation	SNP	A	A	C			TCGA-BA-A4IG-01A-11D-A25Y-08	TCGA-BA-A4IG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	200d5ad1-bd1f-4068-a4e4-4b6a3aaaf92d	df122b02-6d09-4441-af8a-cae70fd20fff	g.chr20:8639305A>C	ENST00000378641.3	+	9	1291	c.816A>C	c.(814-816)caA>caC	p.Q272H	PLCB1_ENST00000378637.2_Missense_Mutation_p.Q272H|PLCB1_ENST00000338037.6_Missense_Mutation_p.Q272H	NM_182734.1	NP_877398.1	Q9NQ66	PLCB1_HUMAN	phospholipase C, beta 1 (phosphoinositide-specific)	272					activation of meiosis involved in egg activation|CD24 biosynthetic process|cerebral cortex development|G1 phase|G2/M transition of mitotic cell cycle|glutamate signaling pathway|insulin-like growth factor receptor signaling pathway|interleukin-1-mediated signaling pathway|interleukin-12-mediated signaling pathway|interleukin-15-mediated signaling pathway|intracellular signal transduction|lipid catabolic process|memory|muscarinic acetylcholine receptor signaling pathway|negative regulation of monocyte extravasation|negative regulation of transcription, DNA-dependent|phosphatidylinositol metabolic process|positive regulation of acrosome reaction|positive regulation of developmental growth|positive regulation of embryonic development|positive regulation of interleukin-12 production|positive regulation of JNK cascade|positive regulation of myoblast differentiation|positive regulation of transcription, DNA-dependent|regulation of fertilization|regulation of G-protein coupled receptor protein signaling pathway|synaptic transmission	cytosol|nuclear chromatin|nuclear speck	calcium ion binding|calmodulin binding|enzyme binding|GTPase activator activity|phosphatidylinositol phospholipase C activity|phosphatidylinositol-4,5-bisphosphate binding|protein homodimerization activity|signal transducer activity			NS(2)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(11)|liver(2)|lung(41)|ovary(4)|prostate(3)|skin(12)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(4)	95						AGCAAGTCCAAGTATTGATTG	0.413000													36	87					0	0	1	0	0
NHLRC1	378884	broad.mit.edu	37	6	18122653	18122653	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-A4IG-01A-11D-A25Y-08	TCGA-BA-A4IG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	200d5ad1-bd1f-4068-a4e4-4b6a3aaaf92d	df122b02-6d09-4441-af8a-cae70fd20fff	g.chr6:18122653C>T	ENST00000340650.3	-	1	198	c.185G>A	c.(184-186)cGc>cAc	p.R62H		NM_198586.2	NP_940988.2	Q6VVB1	NHLC1_HUMAN	NHL repeat containing 1	62					proteasomal ubiquitin-dependent protein catabolic process|protein polyubiquitination	endoplasmic reticulum|nucleus	protein binding|ubiquitin-protein ligase activity|zinc ion binding			breast(1)|kidney(1)|large_intestine(3)|lung(3)|skin(1)|urinary_tract(2)	11	Ovarian(93;0.016)|Breast(50;0.0245)	all_hematologic(90;0.165)	all cancers(50;0.0451)|Epithelial(50;0.0493)			GGCCAGAGTGCGCGGGTGCGC	0.701000													3	17					0	0	1	0	0
OBSCN	84033	broad.mit.edu	37	1	228558406	228558406	+	Frame_Shift_Del	DEL	C	C	-			TCGA-BA-A4IG-01A-11D-A25Y-08	TCGA-BA-A4IG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	200d5ad1-bd1f-4068-a4e4-4b6a3aaaf92d	df122b02-6d09-4441-af8a-cae70fd20fff	g.chr1:228558406delC	ENST00000570156.2	+	104	23138	c.23064delC	c.(23062-23064)cafs	p.H7688fs	OBSCN_ENST00000422127.1_Frame_Shift_Del_p.H6731fs|OBSCN_ENST00000366707.4_Frame_Shift_Del_p.H4365fs	NM_001271223.2	NP_001258152.2	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	6731	Protein kinase 2.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			NS(2)|breast(7)|central_nervous_system(5)|cervix(2)|endometrium(30)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(37)|lung(89)|ovary(8)|pancreas(3)|prostate(13)|skin(6)|stomach(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	223		Prostate(94;0.0405)				AGGAGGCCCACTTCATCAACA	0.612													11	89	---	---	---	---					
CHML	1122	broad.mit.edu	37	1	241798371	241798381	+	Frame_Shift_Del	DEL	AAATCAATATT	AAATCAATATT	-			TCGA-BA-A4IG-01A-11D-A25Y-08	TCGA-BA-A4IG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	200d5ad1-bd1f-4068-a4e4-4b6a3aaaf92d	df122b02-6d09-4441-af8a-cae70fd20fff	g.chr1:241798371_241798381delAAATCAATATT	ENST00000366553.1	-	1	851_861	c.688_698delAATATTGATTT	c.(688-699)gfs	p.NIDL230fs	OPN3_ENST00000469376.1_Intron|OPN3_ENST00000331838.5_Intron|OPN3_ENST00000366554.2_Intron	NM_001821.3	NP_001812.2	P26374	RAE2_HUMAN	choroideremia-like (Rab escort protein 2)	230					intracellular protein transport|visual perception	Rab-protein geranylgeranyltransferase complex	GTPase activator activity|Rab geranylgeranyltransferase activity			breast(2)|endometrium(1)|kidney(2)|large_intestine(6)|lung(7)|ovary(4)|skin(3)|stomach(1)	26	Ovarian(103;0.103)|all_lung(81;0.23)	all_cancers(173;0.0231)	OV - Ovarian serous cystadenocarcinoma(106;0.0125)			TTTTGACACCAAATCAATATTAAACCTCCTG	0.313													39	128	---	---	---	---					
AC011747.6	0	broad.mit.edu	37	2	8743629	8743629	+	RNA	DEL	A	A	-			TCGA-BA-A4IG-01A-11D-A25Y-08	TCGA-BA-A4IG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	200d5ad1-bd1f-4068-a4e4-4b6a3aaaf92d	df122b02-6d09-4441-af8a-cae70fd20fff	g.chr2:8743629delA	ENST00000425678.1	-	0	439																											TGTTTGTACTAAAAAAAAAAA	0.289													3	3	---	---	---	---					
PUS10	150962	broad.mit.edu	37	2	61181120	61181120	+	Frame_Shift_Del	DEL	T	T	-			TCGA-BA-A4IG-01A-11D-A25Y-08	TCGA-BA-A4IG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	200d5ad1-bd1f-4068-a4e4-4b6a3aaaf92d	df122b02-6d09-4441-af8a-cae70fd20fff	g.chr2:61181120delT	ENST00000316752.6	-	14	1399	c.1138delA	c.(1138-1140)ttfs	p.I380fs	PUS10_ENST00000407787.1_Frame_Shift_Del_p.I380fs	NM_144709.2	NP_653310.2	Q3MIT2	PUS10_HUMAN	pseudouridylate synthase 10	380					pseudouridine synthesis|tRNA processing		pseudouridine synthase activity|RNA binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(8)|lung(8)|ovary(2)	22			LUSC - Lung squamous cell carcinoma(5;1.56e-06)|Lung(5;2.48e-05)|Epithelial(17;0.113)			GAGTTATTAATTTTCTGTAGT	0.378													13	69	---	---	---	---					
DNAJC13	23317	broad.mit.edu	37	3	132249931	132249931	+	Frame_Shift_Del	DEL	A	A	-			TCGA-BA-A4IG-01A-11D-A25Y-08	TCGA-BA-A4IG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	200d5ad1-bd1f-4068-a4e4-4b6a3aaaf92d	df122b02-6d09-4441-af8a-cae70fd20fff	g.chr3:132249931delA	ENST00000260818.6	+	55	6863	c.6615delA	c.(6613-6615)ggfs	p.G2205fs		NM_015268.3	NP_056083.3	O75165	DJC13_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 13	2205							heat shock protein binding			breast(4)|endometrium(2)|kidney(2)|large_intestine(5)|lung(15)|ovary(1)|pancreas(2)|prostate(2)|urinary_tract(1)	34						AAACAGCAGGATACCTCACAG	0.413													10	100	---	---	---	---					
LINC01322	103695433	broad.mit.edu	37	3	165320478	165320481	+	RNA	DEL	TATA	TATA	-	rs150429698		TCGA-BA-A4IG-01A-11D-A25Y-08	TCGA-BA-A4IG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	200d5ad1-bd1f-4068-a4e4-4b6a3aaaf92d	df122b02-6d09-4441-af8a-cae70fd20fff	g.chr3:165320478_165320481delTATA	ENST00000496693.1	+	0	508																											atttttattttatatatatatata	0.314													6	10	---	---	---	---					
UBAP2	55833	broad.mit.edu	37	9	33943557	33943560	+	Frame_Shift_Del	DEL	AACC	AACC	-			TCGA-BA-A4IG-01A-11D-A25Y-08	TCGA-BA-A4IG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	200d5ad1-bd1f-4068-a4e4-4b6a3aaaf92d	df122b02-6d09-4441-af8a-cae70fd20fff	g.chr9:33943557_33943560delAACC	ENST00000379238.1	-	15	1690_1693	c.1573_1576delGGTT	c.(1573-1578)cafs	p.GS525fs	UBAP2_ENST00000539807.1_Frame_Shift_Del_p.GS280fs|UBAP2_ENST00000379239.4_Frame_Shift_Del_p.GS258fs|UBAP2_ENST00000360802.1_Frame_Shift_Del_p.GS525fs|UBAP2_ENST00000379225.1_Frame_Shift_Del_p.GS158fs|UBAP2_ENST00000449054.1_Frame_Shift_Del_p.GS525fs|UBAP2_ENST00000418786.2_Frame_Shift_Del_p.GS472fs			Q5T6F2	UBAP2_HUMAN	ubiquitin associated protein 2	525										endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(7)|lung(13)|ovary(3)|stomach(1)	32			LUSC - Lung squamous cell carcinoma(29;0.00575)	GBM - Glioblastoma multiforme(74;0.168)		ACATCTGCTGAACCAGGCATTTCC	0.471													12	71	---	---	---	---					
ARHGAP5	394	broad.mit.edu	37	14	32560921	32560921	+	Frame_Shift_Del	DEL	T	T	-			TCGA-BA-A4IG-01A-11D-A25Y-08	TCGA-BA-A4IG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	200d5ad1-bd1f-4068-a4e4-4b6a3aaaf92d	df122b02-6d09-4441-af8a-cae70fd20fff	g.chr14:32560921delT	ENST00000345122.3	+	2	1361	c.1046delT	c.(1045-1047)ctfs	p.L350fs	ARHGAP5_ENST00000432921.1_Frame_Shift_Del_p.L350fs|ARHGAP5_ENST00000433497.1_Intron|ARHGAP5_ENST00000539826.2_Frame_Shift_Del_p.L350fs|ARHGAP5_ENST00000556611.1_Frame_Shift_Del_p.L350fs|ARHGAP5_ENST00000396582.2_Intron	NM_001030055.1	NP_001025226.1	Q13017	RHG05_HUMAN	Rho GTPase activating protein 5	350					cell adhesion|Rho protein signal transduction	cytosol|membrane	GTP binding|GTPase activity|Rho GTPase activator activity|SH2 domain binding			NS(2)|breast(10)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(10)|lung(12)|ovary(4)|skin(1)|stomach(1)|urinary_tract(4)	55	Hepatocellular(127;0.0604)|Prostate(35;0.15)|Breast(36;0.186)		LUAD - Lung adenocarcinoma(48;0.00192)|Lung(238;0.00714)|BRCA - Breast invasive adenocarcinoma(188;0.0952)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.00566)		TTTAACACTCTTTTGCCAAAT	0.313													60	171	---	---	---	---					
RP5-991G20.1	0	broad.mit.edu	37	16	72763869	72763870	+	RNA	DEL	AA	AA	-			TCGA-BA-A4IG-01A-11D-A25Y-08	TCGA-BA-A4IG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	200d5ad1-bd1f-4068-a4e4-4b6a3aaaf92d	df122b02-6d09-4441-af8a-cae70fd20fff	g.chr16:72763869_72763870delAA	ENST00000563328.2	+	0	164																											GGTCCAAAACAAAAAAAAAAAA	0.431													2	4	---	---	---	---					
ZNF699	374879	broad.mit.edu	37	19	9407234	9407255	+	Frame_Shift_Del	DEL	TTTACATTCATAGTTTGTCTTT	TTTACATTCATAGTTTGTCTTT	-			TCGA-BA-A4IG-01A-11D-A25Y-08	TCGA-BA-A4IG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	200d5ad1-bd1f-4068-a4e4-4b6a3aaaf92d	df122b02-6d09-4441-af8a-cae70fd20fff	g.chr19:9407234_9407255delTTTACATTCATAGTTTGTCTTT	ENST00000591998.1	-	6	1053_1074	c.825_846delAAAGACAAACTATGAATGTAAA	c.(823-846)ggfs	p.GKTNYECK275fs	ZNF699_ENST00000308650.3_Frame_Shift_Del_p.GKTNYECK275fs			Q32M78	ZN699_HUMAN	zinc finger protein 699	275					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(7)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	24						TCCCACATTCTTTACATTCATAGTTTGTCTTTCCGATGTGAA	0.410													7	113	---	---	---	---