Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
ZNF496	84838	broad.mit.edu	37	1	247464555	247464555	+	Nonsense_Mutation	SNP	C	C	A			TCGA-BA-A6DB-01A-11D-A30E-08	TCGA-BA-A6DB-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	041344f2-1b9f-4679-aa68-cc4b7c4b1c16	5ffe305e-72e6-46e1-be69-b42dca5ab179	g.chr1:247464555C>A	ENST00000294753.4	-	9	1494	c.1030G>T	c.(1030-1032)Gag>Tag	p.E344*	ZNF496_ENST00000462139.1_5'UTR|ZNF496_ENST00000366498.2_Nonsense_Mutation_p.E380*	NM_032752.1	NP_116141.1	Q96IT1	ZN496_HUMAN	zinc finger protein 496	344					positive regulation of transcription, DNA-dependent|viral reproduction		DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.E344Q(1)		NS(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(5)|lung(13)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	36	all_cancers(71;0.000136)|all_epithelial(71;2.62e-05)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0607)|Lung NSC(105;0.0661)		OV - Ovarian serous cystadenocarcinoma(106;0.00703)			AGGCTGTTCTCTAGAGATCGC	0.612000													6	130					8.12818e-05	8.12818e-05	1	1	0
GTF3C1	2975	broad.mit.edu	37	16	27518206	27518206	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-A6DB-01A-11D-A30E-08	TCGA-BA-A6DB-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	041344f2-1b9f-4679-aa68-cc4b7c4b1c16	5ffe305e-72e6-46e1-be69-b42dca5ab179	g.chr16:27518206C>T	ENST00000356183.4	-	9	1529	c.1514G>A	c.(1513-1515)cGg>cAg	p.R505Q	GTF3C1_ENST00000561623.1_Missense_Mutation_p.R505Q	NM_001520.3	NP_001511.2	Q12789	TF3C1_HUMAN	general transcription factor IIIC, polypeptide 1, alpha 220kDa	505						transcription factor TFIIIC complex	DNA binding|protein binding			breast(2)|central_nervous_system(4)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(14)|liver(3)|lung(28)|ovary(2)|pancreas(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)	80						GGTCTTGGGCCGGAGGTTTGC	0.622000													3	28					0	0	1	0	0
HELZ2	85441	broad.mit.edu	37	20	62196246	62196246	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-A6DB-01A-11D-A30E-08	TCGA-BA-A6DB-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	041344f2-1b9f-4679-aa68-cc4b7c4b1c16	5ffe305e-72e6-46e1-be69-b42dca5ab179	g.chr20:62196246G>A	ENST00000467148.1	-	8	3998	c.3929C>T	c.(3928-3930)cCg>cTg	p.P1310L	HELZ2_ENST00000427522.2_Missense_Mutation_p.P741L	NM_001037335.2	NP_001032412.2			helicase with zinc finger 2, transcriptional coactivator																		CTGGTCCGACGGGGGCACCCT	0.672000													7	72					0	0	1	0	0
LPIN2	9663	broad.mit.edu	37	18	2921574	2921574	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-A6DB-01A-11D-A30E-08	TCGA-BA-A6DB-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	041344f2-1b9f-4679-aa68-cc4b7c4b1c16	5ffe305e-72e6-46e1-be69-b42dca5ab179	g.chr18:2921574G>A	ENST00000261596.4	-	18	2637	c.2399C>T	c.(2398-2400)cCg>cTg	p.P800L		NM_014646.2	NP_055461.1	Q92539	LPIN2_HUMAN	lipin 2	800	C-LIP.				fatty acid metabolic process|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent|triglyceride biosynthetic process	cytosol|endoplasmic reticulum membrane|nucleus	phosphatidate phosphatase activity|transcription coactivator activity			autonomic_ganglia(1)|breast(1)|endometrium(2)|large_intestine(4)|lung(16)|ovary(1)|pancreas(1)|prostate(2)|skin(1)	29				READ - Rectum adenocarcinoma(2;0.0419)|Colorectal(6;0.156)		CTGCTTAGACGGGGCAAACAG	0.403000													9	94					0	0	1	0	0
NUDT2	318	broad.mit.edu	37	9	34343282	34343282	+	Silent	SNP	G	G	A			TCGA-BA-A6DB-01A-11D-A30E-08	TCGA-BA-A6DB-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	041344f2-1b9f-4679-aa68-cc4b7c4b1c16	5ffe305e-72e6-46e1-be69-b42dca5ab179	g.chr9:34343282G>A	ENST00000379158.2	+	5	646	c.288G>A	c.(286-288)gcG>gcA	p.A96A	NUDT2_ENST00000346365.4_Silent_p.A96A|NUDT2_ENST00000379155.5_Silent_p.A96A	NM_001161.4	NP_001152.1	P50583	AP4A_HUMAN	nudix (nucleoside diphosphate linked moiety X)-type motif 2	96	Nudix hydrolase.				induction of apoptosis|nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity|bis(5'-nucleosyl)-tetraphosphatase (symmetrical) activity|GTP binding			lung(3)	3			LUSC - Lung squamous cell carcinoma(29;0.0107)	GBM - Glioblastoma multiforme(74;0.126)		ACTGGCTGGCGGAGGTGAAGG	0.552000													5	154					0	0	1	0	0
TNFAIP8	25816	broad.mit.edu	37	5	118728831	118728831	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BA-A6DB-01A-11D-A30E-08	TCGA-BA-A6DB-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	041344f2-1b9f-4679-aa68-cc4b7c4b1c16	5ffe305e-72e6-46e1-be69-b42dca5ab179	g.chr5:118728831C>T	ENST00000504771.2	+	2	2129	c.352C>T	c.(352-354)Cag>Tag	p.Q118*	TNFAIP8_ENST00000274456.6_Nonsense_Mutation_p.Q108*|TNFAIP8_ENST00000504642.1_Nonsense_Mutation_p.Q120*|TNFAIP8_ENST00000503646.1_Nonsense_Mutation_p.Q118*|TNFAIP8_ENST00000513374.1_Nonsense_Mutation_p.Q130*|TNFAIP8_ENST00000415806.2_3'UTR	NM_014350.2	NP_055165.2	O95379	TFIP8_HUMAN	tumor necrosis factor, alpha-induced protein 8	118					anti-apoptosis|apoptosis|negative regulation of anti-apoptosis	cytoplasm	caspase inhibitor activity|protein binding			ovary(1)	1		all_cancers(142;0.0317)|Prostate(80;0.111)|Breast(839;0.231)		Epithelial(69;4.63e-83)|OV - Ovarian serous cystadenocarcinoma(64;1.39e-82)|all cancers(49;4.88e-75)|GBM - Glioblastoma multiforme(465;0.00338)|BRCA - Breast invasive adenocarcinoma(61;0.0148)|COAD - Colon adenocarcinoma(49;0.0829)		CAGTTTCCATCAGGTGGATTA	0.413000													16	57					0	0	1	0	0
TSSC2	650368	broad.mit.edu	37	11	3427845	3427845	+	RNA	SNP	C	C	T			TCGA-BA-A6DB-01A-11D-A30E-08	TCGA-BA-A6DB-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	041344f2-1b9f-4679-aa68-cc4b7c4b1c16	5ffe305e-72e6-46e1-be69-b42dca5ab179	g.chr11:3427845C>T	ENST00000529482.1	+	0	962																											CTTCAAGTGGCAGGAGCAGAA	0.587000													6	58					0	0	1	0	0
ZFHX3	463	broad.mit.edu	37	16	72821615	72821615	+	Silent	SNP	G	G	A			TCGA-BA-A6DB-01A-11D-A30E-08	TCGA-BA-A6DB-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	041344f2-1b9f-4679-aa68-cc4b7c4b1c16	5ffe305e-72e6-46e1-be69-b42dca5ab179	g.chr16:72821615G>A	ENST00000268489.5	-	10	11232	c.10560C>T	c.(10558-10560)ggC>ggT	p.G3520G	ZFHX3_ENST00000397992.5_Silent_p.G2606G|AC004943.1_ENST00000584072.1_RNA	NM_006885.3	NP_008816.3	Q15911	ZFHX3_HUMAN	zinc finger homeobox 3	3520	Poly-Gly.				muscle organ development|negative regulation of myoblast differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|positive regulation of myoblast differentiation	transcription factor complex	enzyme binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			NS(3)|breast(7)|cervix(2)|endometrium(18)|haematopoietic_and_lymphoid_tissue(5)|kidney(8)|large_intestine(22)|liver(1)|lung(46)|ovary(5)|pancreas(1)|prostate(15)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(11)	153		Ovarian(137;0.13)				cgccgccgccgccaccgccgc	0.706000													4	48					0	0	1	0	0
MTUS2	23281	broad.mit.edu	37	13	29608227	29608227	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-A6DB-01A-11D-A30E-08	TCGA-BA-A6DB-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	041344f2-1b9f-4679-aa68-cc4b7c4b1c16	5ffe305e-72e6-46e1-be69-b42dca5ab179	g.chr13:29608227C>A	ENST00000431530.3	+	2	2499	c.2441C>A	c.(2440-2442)aCa>aAa	p.T814K		NM_001033602.2	NP_001028774.2	Q5JR59	MTUS2_HUMAN	microtubule associated tumor suppressor candidate 2	804	Localization to the growing distal tip of microtubules.|Mediates interaction with MAPRE1.|Sufficient for interaction with KIF2C.					cytoplasm|microtubule	microtubule binding|protein homodimerization activity			NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(3)|prostate(1)|skin(1)	20						GGACCCATAACAACAGCCACC	0.493000													7	68					5.18039e-06	5.36216e-06	1	1	0
PADI1	29943	broad.mit.edu	37	1	17548859	17548859	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-A6DB-01A-11D-A30E-08	TCGA-BA-A6DB-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	041344f2-1b9f-4679-aa68-cc4b7c4b1c16	5ffe305e-72e6-46e1-be69-b42dca5ab179	g.chr1:17548859G>A	ENST00000375471.4	+	2	259	c.167G>A	c.(166-168)cGc>cAc	p.R56H		NM_013358.2	NP_037490.2	Q9ULC6	PADI1_HUMAN	peptidyl arginine deiminase, type I	56					peptidyl-citrulline biosynthetic process from peptidyl-arginine	cytoplasm	calcium ion binding|protein-arginine deiminase activity			haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(14)|ovary(1)|prostate(4)|skin(1)|stomach(1)|urinary_tract(1)	28		Colorectal(325;3.46e-05)|Breast(348;0.000162)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.00054)|Ovarian(437;0.00409)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00522)|BRCA - Breast invasive adenocarcinoma(304;1.3e-05)|COAD - Colon adenocarcinoma(227;1.31e-05)|Kidney(64;0.000212)|KIRC - Kidney renal clear cell carcinoma(64;0.003)|STAD - Stomach adenocarcinoma(196;0.0069)|READ - Rectum adenocarcinoma(331;0.0681)|Lung(427;0.197)	L-Citrulline(DB00155)	GTCTACAACCGCACACGTGTG	0.557000													6	153					0	0	1	0	0
ZMPSTE24	10269	broad.mit.edu	37	1	40758218	40758218	+	Silent	SNP	A	A	G			TCGA-BA-A6DB-01A-11D-A30E-08	TCGA-BA-A6DB-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	041344f2-1b9f-4679-aa68-cc4b7c4b1c16	5ffe305e-72e6-46e1-be69-b42dca5ab179	g.chr1:40758218A>G	ENST00000372759.3	+	10	1470	c.1305A>G	c.(1303-1305)ttA>ttG	p.L435L		NM_005857.4	NP_005848.2	O75844	FACE1_HUMAN	zinc metallopeptidase STE24	435						endoplasmic reticulum membrane|Golgi membrane|integral to membrane	metal ion binding|metalloexopeptidase activity			endometrium(3)|kidney(3)|large_intestine(4)|lung(4)|prostate(1)|skin(1)	16	Lung NSC(20;4.38e-06)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;6.3e-18)			ATTCTGCTTTAATCAAACTTA	0.393000													16	121					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179399635	179399635	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-A6DB-01A-11D-A30E-08	TCGA-BA-A6DB-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	041344f2-1b9f-4679-aa68-cc4b7c4b1c16	5ffe305e-72e6-46e1-be69-b42dca5ab179	g.chr2:179399635G>A	ENST00000589042.1	-	358	101931	c.101707C>T	c.(101707-101709)Cgc>Tgc	p.R33903C	TTN-AS1_ENST00000450692.2_RNA|TTN-AS1_ENST00000589842.1_RNA|TTN-AS1_ENST00000588716.1_RNA|TTN-AS1_ENST00000442329.2_RNA|TTN-AS1_ENST00000592836.1_RNA|TTN-AS1_ENST00000590040.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.R25030C|TTN-AS1_ENST00000592600.1_RNA|TTN-AS1_ENST00000589434.1_RNA|TTN-AS1_ENST00000591867.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.R24963C|TTN-AS1_ENST00000589391.1_RNA|TTN-AS1_ENST00000431259.2_RNA|TTN-AS1_ENST00000588804.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000592182.1_RNA|TTN-AS1_ENST00000586831.1_RNA|TTN-AS1_ENST00000585358.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN-AS1_ENST00000456053.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000591466.1_RNA|TTN-AS1_ENST00000586707.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.R24838C|TTN-AS1_ENST00000419746.1_RNA|TTN-AS1_ENST00000585487.1_RNA|TTN-AS1_ENST00000588257.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.R31335C|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.R32262C|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000588244.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	32262							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GTGTTAATGCGCTCAAATATG	0.343000													4	72					0	0	1	0	0
ALPK3	57538	broad.mit.edu	37	15	85400343	85400343	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-A6DB-01A-11D-A30E-08	TCGA-BA-A6DB-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	041344f2-1b9f-4679-aa68-cc4b7c4b1c16	5ffe305e-72e6-46e1-be69-b42dca5ab179	g.chr15:85400343G>C	ENST00000258888.5	+	6	3147	c.2980G>C	c.(2980-2982)Ggt>Cgt	p.G994R		NM_020778.4	NP_065829.3	Q96L96	ALPK3_HUMAN	alpha-kinase 3	994					heart development	nucleus	ATP binding|protein serine/threonine kinase activity			NS(3)|breast(2)|central_nervous_system(2)|endometrium(12)|kidney(4)|large_intestine(9)|lung(27)|ovary(3)|prostate(5)|skin(8)|stomach(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	81			BRCA - Breast invasive adenocarcinoma(143;0.0587)			AACTGTGCTGGGTCCCCTGTC	0.592000													11	103					0	0	1	0	0
KCNB2	9312	broad.mit.edu	37	8	73480479	73480479	+	Silent	SNP	C	C	A			TCGA-BA-A6DB-01A-11D-A30E-08	TCGA-BA-A6DB-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	041344f2-1b9f-4679-aa68-cc4b7c4b1c16	5ffe305e-72e6-46e1-be69-b42dca5ab179	g.chr8:73480479C>A	ENST00000523207.1	+	2	1098	c.510C>A	c.(508-510)acC>acA	p.T170T		NM_004770.2	NP_004761.2	Q92953	KCNB2_HUMAN	potassium voltage-gated channel, Shab-related subfamily, member 2	170					regulation of smooth muscle contraction	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(20)|liver(2)|lung(31)|ovary(2)|pancreas(3)|prostate(2)|skin(8)|upper_aerodigestive_tract(4)|urinary_tract(1)	85	Breast(64;0.137)		Epithelial(68;0.105)			TTGATAATACCTGCTGCCCTG	0.453000													20	207					1.15919e-05	1.17917e-05	1	1	0
PCLO	27445	broad.mit.edu	37	7	82784965	82784965	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-A6DB-01A-11D-A30E-08	TCGA-BA-A6DB-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	041344f2-1b9f-4679-aa68-cc4b7c4b1c16	5ffe305e-72e6-46e1-be69-b42dca5ab179	g.chr7:82784965G>C	ENST00000423517.2	-	2	1329	c.992C>G	c.(991-993)cCc>cGc	p.P331R	PCLO_ENST00000333891.8_Missense_Mutation_p.P331R	NM_014510.2	NP_055325.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein	314	Gln-rich.|Pro-rich.				cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						CTGAGCTGGGGGCTTTGCAGG	0.567000													4	41					0	0	1	0	0
DNAH3	55567	broad.mit.edu	37	16	21145740	21145740	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-A6DB-01A-11D-A30E-08	TCGA-BA-A6DB-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	041344f2-1b9f-4679-aa68-cc4b7c4b1c16	5ffe305e-72e6-46e1-be69-b42dca5ab179	g.chr16:21145740G>A	ENST00000261383.3	-	7	921	c.922C>T	c.(922-924)Cgg>Tgg	p.R308W	DNAH3_ENST00000415178.1_Missense_Mutation_p.R308W	NM_017539.1	NP_060009.1	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	308	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity	p.R308W(2)		NS(3)|autonomic_ganglia(1)|breast(12)|central_nervous_system(3)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(42)|liver(2)|lung(57)|ovary(14)|pancreas(1)|prostate(7)|skin(11)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(6)	202				GBM - Glioblastoma multiforme(48;0.207)		ATAAAGAGCCGTTTTCTCTCC	0.507000													4	120					0	0	1	0	0
RNF123	63891	broad.mit.edu	37	3	49738118	49738118	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-A6DB-01A-11D-A30E-08	TCGA-BA-A6DB-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	041344f2-1b9f-4679-aa68-cc4b7c4b1c16	5ffe305e-72e6-46e1-be69-b42dca5ab179	g.chr3:49738118G>A	ENST00000327697.6	+	15	1397	c.1253G>A	c.(1252-1254)cGc>cAc	p.R418H	RNF123_ENST00000432042.1_Missense_Mutation_p.R272H	NM_022064.3	NP_071347.2	Q5XPI4	RN123_HUMAN	ring finger protein 123	418						cytoplasm	ligase activity|protein binding|zinc ion binding			NS(1)|breast(4)|cervix(2)|endometrium(4)|kidney(4)|large_intestine(6)|lung(11)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	38				BRCA - Breast invasive adenocarcinoma(193;4.71e-05)|Kidney(197;0.00227)|KIRC - Kidney renal clear cell carcinoma(197;0.00255)		GAGAAGTCCCGCAAGTTTCTG	0.597000													4	132					0	0	1	0	0
YLPM1	56252	broad.mit.edu	37	14	75248427	75248427	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-A6DB-01A-11D-A30E-08	TCGA-BA-A6DB-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	041344f2-1b9f-4679-aa68-cc4b7c4b1c16	5ffe305e-72e6-46e1-be69-b42dca5ab179	g.chr14:75248427C>T	ENST00000325680.7	+	4	1805	c.1681C>T	c.(1681-1683)Ccc>Tcc	p.P561S	YLPM1_ENST00000238571.3_Intron|YLPM1_ENST00000552421.1_Missense_Mutation_p.P561S	NM_019589.2	NP_062535.2	P49750	YLPM1_HUMAN	YLP motif containing 1	363					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear speck				breast(4)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(12)|lung(24)|ovary(3)|pancreas(1)|prostate(1)|skin(1)|urinary_tract(1)	62			KIRC - Kidney renal clear cell carcinoma(43;0.238)	BRCA - Breast invasive adenocarcinoma(234;0.00162)		ACCTGGCATGCCCCCACCTGT	0.612000													5	275					0	0	1	0	0
ANGPTL3	27329	broad.mit.edu	37	1	63069735	63069735	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-A6DB-01A-11D-A30E-08	TCGA-BA-A6DB-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	041344f2-1b9f-4679-aa68-cc4b7c4b1c16	5ffe305e-72e6-46e1-be69-b42dca5ab179	g.chr1:63069735C>T	ENST00000371129.3	+	6	1107	c.1027C>T	c.(1027-1029)Cat>Tat	p.H343Y	DOCK7_ENST00000404627.2_Intron|DOCK7_ENST00000340370.5_Intron|ANGPTL3_ENST00000493994.1_3'UTR|DOCK7_ENST00000251157.5_Intron	NM_014495.2	NP_055310.1	Q9Y5C1	ANGL3_HUMAN	angiopoietin-like 3	343	Fibrinogen C-terminal.				acylglycerol homeostasis|artery morphogenesis|cell-matrix adhesion|cholesterol homeostasis|cholesterol metabolic process|fatty acid metabolic process|glycerol metabolic process|integrin-mediated signaling pathway|lipid storage|negative regulation of lipoprotein lipase activity|negative regulation of phospholipase activity|phospholipid catabolic process|phospholipid homeostasis|positive regulation of angiogenesis|positive regulation of cell migration|positive regulation of lipid catabolic process|triglyceride homeostasis	extracellular space	cell surface binding|growth factor activity|integrin binding|phospholipase inhibitor activity			breast(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(3)|urinary_tract(1)	13						AGACAACAAACATTATATTGA	0.368000													10	239					0	0	1	0	0
CROCCP2	84809	broad.mit.edu	37	1	16959602	16959602	+	RNA	SNP	C	C	T	rs1807293	by1000genomes	TCGA-BA-A6DB-01A-11D-A30E-08	TCGA-BA-A6DB-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	041344f2-1b9f-4679-aa68-cc4b7c4b1c16	5ffe305e-72e6-46e1-be69-b42dca5ab179	g.chr1:16959602C>T	ENST00000412962.1	-	0	74																		p.A88A(2)									TCTGCAGTGACGCCTGCCTCA	0.602000													5	37					0	0	1	0	0
PPFIA4	8497	broad.mit.edu	37	1	203029424	203029424	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-A6DB-01A-11D-A30E-08	TCGA-BA-A6DB-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	041344f2-1b9f-4679-aa68-cc4b7c4b1c16	5ffe305e-72e6-46e1-be69-b42dca5ab179	g.chr1:203029424C>T	ENST00000367240.2	+	21	3127	c.2600C>T	c.(2599-2601)tCg>tTg	p.S867L	PPFIA4_ENST00000447715.2_Missense_Mutation_p.S866L|PPFIA4_ENST00000414050.2_Missense_Mutation_p.S595L|PPFIA4_ENST00000295706.4_Missense_Mutation_p.S382L|PPFIA4_ENST00000599966.1_Missense_Mutation_p.S382L|PPFIA4_ENST00000272198.6_Missense_Mutation_p.S382L			O75335	LIPA4_HUMAN	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4	382					cell communication	cell surface|cytoplasm	protein binding			NS(1)|autonomic_ganglia(1)|breast(3)|endometrium(6)|kidney(2)|large_intestine(8)|lung(20)|ovary(4)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	50						TCCGCTCTGTCGGACACAGAG	0.632000													4	105					0	0	1	0	0
KIAA1024	23251	broad.mit.edu	37	15	79755514	79755514	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-A6DB-01A-11D-A30E-08	TCGA-BA-A6DB-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	041344f2-1b9f-4679-aa68-cc4b7c4b1c16	5ffe305e-72e6-46e1-be69-b42dca5ab179	g.chr15:79755514C>T	ENST00000305428.3	+	3	2479	c.2404C>T	c.(2404-2406)Ctc>Ttc	p.L802F		NM_015206.2	NP_056021.1	Q9UPX6	K1024_HUMAN	KIAA1024	802						integral to membrane				central_nervous_system(2)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(13)|lung(23)|ovary(2)|pancreas(2)|prostate(1)	49						CCCTGCCTCCCTCAAGGCCCA	0.607000													5	102					0	0	1	0	0
HKR1	284459	broad.mit.edu	37	19	37854409	37854409	+	Missense_Mutation	SNP	A	A	T			TCGA-BA-A6DB-01A-11D-A30E-08	TCGA-BA-A6DB-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	041344f2-1b9f-4679-aa68-cc4b7c4b1c16	5ffe305e-72e6-46e1-be69-b42dca5ab179	g.chr19:37854409A>T	ENST00000591471.1	+	9	2534	c.893A>T	c.(892-894)cAc>cTc	p.H298L	HKR1_ENST00000541583.2_Missense_Mutation_p.H510L|HKR1_ENST00000544914.1_Missense_Mutation_p.H298L|HKR1_ENST00000392153.3_Missense_Mutation_p.H552L|HKR1_ENST00000324411.4_Missense_Mutation_p.H571L|HKR1_ENST00000591134.1_Intron|HKR1_ENST00000589392.1_Missense_Mutation_p.H553L			P10072	HKR1_HUMAN	HKR1, GLI-Kruppel zinc finger family member	571					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			cervix(1)|endometrium(3)|kidney(2)|large_intestine(10)|lung(9)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	29			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			CTGTTTAGGCACAAGAGGGCA	0.522000													12	53					0	0	1	0	0
FLG	2312	broad.mit.edu	37	1	152284263	152284263	+	Silent	SNP	G	G	A	rs146128865	byFrequency	TCGA-BA-A6DB-01A-11D-A30E-08	TCGA-BA-A6DB-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	041344f2-1b9f-4679-aa68-cc4b7c4b1c16	5ffe305e-72e6-46e1-be69-b42dca5ab179	g.chr1:152284263G>A	ENST00000368799.1	-	3	3134	c.3099C>T	c.(3097-3099)caC>caT	p.H1033H	FLG-AS1_ENST00000420707.1_RNA|FLG-AS1_ENST00000593011.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	1033	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GGCGGGATCCGTGTCTTTCTC	0.567000									Ichthyosis				7	779					0	0	1	0	0
TRPM7	54822	broad.mit.edu	37	15	50875314	50875314	+	Missense_Mutation	SNP	T	T	C			TCGA-BA-A6DB-01A-11D-A30E-08	TCGA-BA-A6DB-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	041344f2-1b9f-4679-aa68-cc4b7c4b1c16	5ffe305e-72e6-46e1-be69-b42dca5ab179	g.chr15:50875314T>C	ENST00000313478.7	-	29	4810	c.4529A>G	c.(4528-4530)gAa>gGa	p.E1510G	TRPM7_ENST00000560955.1_Missense_Mutation_p.E1509G	NM_017672.4	NP_060142.3	Q96QT4	TRPM7_HUMAN	transient receptor potential cation channel, subfamily M, member 7	1510					cell death	integral to membrane	ATP binding|calcium channel activity|metal ion binding|protein serine/threonine kinase activity			breast(3)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(17)|lung(13)|ovary(4)|pancreas(1)|skin(4)|stomach(3)	52				all cancers(107;0.000819)|GBM - Glioblastoma multiforme(94;0.0045)		GGAATCTACTTCATGAGTGTC	0.274000													4	59					0	0	1	0	0
PRR5	55615	broad.mit.edu	37	22	45133065	45133065	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-A6DB-01A-11D-A30E-08	TCGA-BA-A6DB-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	041344f2-1b9f-4679-aa68-cc4b7c4b1c16	5ffe305e-72e6-46e1-be69-b42dca5ab179	g.chr22:45133065C>T	ENST00000403581.1	+	10	1783	c.1174C>T	c.(1174-1176)Cgg>Tgg	p.R392W	PRR5-ARHGAP8_ENST00000352766.7_Intron|ARHGAP8_ENST00000389773.5_Intron|ARHGAP8_ENST00000517296.3_Intron|PRR5-ARHGAP8_ENST00000361473.5_Intron|PRR5_ENST00000336985.6_Missense_Mutation_p.R369W|PRR5_ENST00000477331.1_3'UTR	NM_001198721.1	NP_001185650.1			proline rich 5 (renal)											central_nervous_system(1)|endometrium(2)|lung(6)|prostate(1)|skin(1)	11		all_neural(38;0.00409)|Ovarian(80;0.024)|Glioma(61;0.0647)		UCEC - Uterine corpus endometrioid carcinoma (28;0.168)		TGACTTTGGCCGGGGCCGGGG	0.632000													10	122					0	0	1	0	0
INTS9	55756	broad.mit.edu	37	8	28625720	28625720	+	Silent	SNP	G	G	A	rs149143087		TCGA-BA-A6DB-01A-11D-A30E-08	TCGA-BA-A6DB-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	041344f2-1b9f-4679-aa68-cc4b7c4b1c16	5ffe305e-72e6-46e1-be69-b42dca5ab179	g.chr8:28625720G>A	ENST00000416984.2	-	16	2216	c.1857C>T	c.(1855-1857)gaC>gaT	p.D619D	INTS9_ENST00000397363.4_Silent_p.D534D|INTS9_ENST00000521022.1_Silent_p.D640D|INTS9_ENST00000521777.1_Silent_p.D616D	NM_001145159.2	NP_001138631.1	Q9NV88	INT9_HUMAN	integrator complex subunit 9	640					snRNA processing	integrator complex	protein binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(6)|pancreas(2)|prostate(1)|urinary_tract(2)	19		Ovarian(32;0.0439)		KIRC - Kidney renal clear cell carcinoma(542;0.127)|Kidney(114;0.152)		TGAGCATCTCGTCATTGTCGC	0.532000													5	344					0	0	1	0	0
TP53	7157	broad.mit.edu	37	17	7577121	7577121	+	Missense_Mutation	SNP	G	G	A	rs121913343		TCGA-BA-A6DB-01A-11D-A30E-08	TCGA-BA-A6DB-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	041344f2-1b9f-4679-aa68-cc4b7c4b1c16	5ffe305e-72e6-46e1-be69-b42dca5ab179	g.chr17:7577121G>A	ENST00000420246.2	-	8	949	c.817C>T	c.(817-819)Cgt>Tgt	p.R273C	TP53_ENST00000413465.2_Intron|TP53_ENST00000445888.2_Missense_Mutation_p.R273C|TP53_ENST00000269305.4_Missense_Mutation_p.R273C|TP53_ENST00000359597.4_Missense_Mutation_p.R273C|TP53_ENST00000455263.2_Missense_Mutation_p.R273C	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	273	Interaction with AXIN1 (By similarity).|Interaction with DNA.|Interaction with E4F1.|Interaction with HIPK1 (By similarity).		R -> C (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> G (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> H (in LFS; germline mutation and in sporadic cancers; somatic mutation; abolishes sequence-specific DNA binding; dbSNP:rs28934576).|R -> L (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> N (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|R -> P (in sporadic cancers; somatic mutation).|R -> Q (in sporadic cancers; somatic mutation).|R -> S (in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> Y (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R273C(481)|p.R273S(16)|p.R273G(9)|p.0?(8)|p.?(2)|p.R273fs*72(2)|p.R273fs*33(2)|p.R273fs*32(2)|p.V272>?(2)|p.F270fs*72(1)|p.R273_C275delRVC(1)|p.L265_K305del41(1)|p.S269fs*21(1)|p.E258fs*71(1)|p.R273fs*71(1)|p.F270_D281del12(1)|p.E271_R273delEVR(1)|p.V272_K292del21(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GCACAAACACGCACCTCAAAG	0.542000	R273C(8MGBA_CENTRAL_NERVOUS_SYSTEM)|R273C(BL70_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273C(EFO27_OVARY)|R273C(KARPAS299_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273C(MFE319_ENDOMETRIUM)|R273C(NCIH1048_LUNG)|R273C(PANC0213_PANCREAS)|R273C(PF382_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273C(RDES_BONE)|R273C(RH30_SOFT_TISSUE)|R273C(RPMI8402_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273C(SH10TC_STOMACH)|R273C(SJRH30_SOFT_TISSUE)|R273C(SUDHL4_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273C(SW1710_URINARY_TRACT)|R273C(SW1783_CENTRAL_NERVOUS_SYSTEM)|R273C(TT2609C02_THYROID)	111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			6	31					0	0	1	0	0
KLHL6	89857	broad.mit.edu	37	3	183210454	183210454	+	Silent	SNP	G	G	A			TCGA-BA-A6DB-01A-11D-A30E-08	TCGA-BA-A6DB-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	041344f2-1b9f-4679-aa68-cc4b7c4b1c16	5ffe305e-72e6-46e1-be69-b42dca5ab179	g.chr3:183210454G>A	ENST00000341319.3	-	6	1427	c.1392C>T	c.(1390-1392)acC>acT	p.T464T		NM_130446.2	NP_569713.2	Q8WZ60	KLHL6_HUMAN	kelch-like family member 6	464										breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(7)|kidney(1)|large_intestine(6)|liver(1)|lung(16)|ovary(2)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	44	all_cancers(143;9.2e-12)|Ovarian(172;0.0172)		all cancers(12;1.29e-44)|Epithelial(37;1.24e-38)|LUSC - Lung squamous cell carcinoma(7;2.58e-24)|Lung(8;1.79e-22)|OV - Ovarian serous cystadenocarcinoma(80;2.32e-22)			TCTTATGGCTGGTGGCTGCAA	0.542000													9	81					0	0	1	0	0
PLCL1	5334	broad.mit.edu	37	2	198949735	198949735	+	Silent	SNP	G	G	A			TCGA-BA-A6DB-01A-11D-A30E-08	TCGA-BA-A6DB-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	041344f2-1b9f-4679-aa68-cc4b7c4b1c16	5ffe305e-72e6-46e1-be69-b42dca5ab179	g.chr2:198949735G>A	ENST00000428675.1	+	2	1892	c.1494G>A	c.(1492-1494)ccG>ccA	p.P498P	PLCL1_ENST00000437704.2_Silent_p.P400P	NM_006226.3	NP_006217.3	Q15111	PLCL1_HUMAN	phospholipase C-like 1	498	PI-PLC X-box.				intracellular signal transduction|lipid metabolic process	cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(8)|kidney(1)|large_intestine(14)|lung(44)|ovary(1)|pancreas(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	80					Quinacrine(DB01103)	GCTCCTTGCCGCAGCAGAAGG	0.418000													4	52					0	0	1	0	0
TRO	7216	broad.mit.edu	37	X	54957319	54957319	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-A6DB-01A-11D-A30E-08	TCGA-BA-A6DB-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	041344f2-1b9f-4679-aa68-cc4b7c4b1c16	5ffe305e-72e6-46e1-be69-b42dca5ab179	g.chrX:54957319G>A	ENST00000173898.7	+	12	4274	c.4162G>A	c.(4162-4164)Ggt>Agt	p.G1388S	TRO_ENST00000375041.2_Missense_Mutation_p.G991S|TRO_ENST00000375022.4_Intron|TRO_ENST00000399736.1_Intron|TRO_ENST00000319167.8_Intron|TRO_ENST00000420798.2_Missense_Mutation_p.G919S	NM_001039705.1	NP_001034794.1	Q12816	TROP_HUMAN	trophinin	1388	62 X 10 AA approximate tandem repeats.				embryo implantation|homophilic cell adhesion	integral to plasma membrane				breast(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(19)|ovary(2)|skin(2)|urinary_tract(1)	37						TGGCTTCAGCGGTGGACCGAG	0.612000													4	194					0	0	1	0	0
APCDD1	147495	broad.mit.edu	37	18	10471888	10471888	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-A6DB-01A-11D-A30E-08	TCGA-BA-A6DB-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	041344f2-1b9f-4679-aa68-cc4b7c4b1c16	5ffe305e-72e6-46e1-be69-b42dca5ab179	g.chr18:10471888G>A	ENST00000355285.4	+	3	958	c.604G>A	c.(604-606)Gtg>Atg	p.V202M	APCDD1_ENST00000578882.1_Intron|APCDD1_ENST00000584596.1_3'UTR	NM_153000.4	NP_694545.1	Q8J025	APCD1_HUMAN	adenomatosis polyposis coli down-regulated 1	202					hair follicle development|negative regulation of Wnt receptor signaling pathway|Wnt receptor signaling pathway	integral to plasma membrane	Wnt-protein binding			NS(1)|breast(1)|endometrium(3)|large_intestine(5)|lung(7)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	22				READ - Rectum adenocarcinoma(15;0.08)		CACCAAGGCCGTGAACTTTGC	0.607000													5	276					0	0	1	0	0
SSH1	54434	broad.mit.edu	37	12	109201543	109201543	+	Silent	SNP	G	G	A			TCGA-BA-A6DB-01A-11D-A30E-08	TCGA-BA-A6DB-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	041344f2-1b9f-4679-aa68-cc4b7c4b1c16	5ffe305e-72e6-46e1-be69-b42dca5ab179	g.chr12:109201543G>A	ENST00000326495.5	-	8	690	c.597C>T	c.(595-597)ccC>ccT	p.P199P	SSH1_ENST00000360239.3_5'UTR|SSH1_ENST00000551165.1_Silent_p.P199P|SSH1_ENST00000326470.5_Silent_p.P210P	NM_018984.3	NP_061857.3	Q8WYL5	SSH1_HUMAN	slingshot protein phosphatase 1	199					actin cytoskeleton organization|cell morphogenesis|cellular response to ATP|regulation of actin polymerization or depolymerization|regulation of axonogenesis|regulation of cellular protein metabolic process|regulation of lamellipodium assembly	cleavage furrow|cytoplasm|cytoskeleton|lamellipodium|midbody|plasma membrane	actin binding|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			breast(1)|endometrium(5)|kidney(3)|large_intestine(9)|lung(8)|ovary(4)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	38						CTACACCCCCGGGGAAGTAGT	0.612000													4	83					0	0	1	0	0
NCOA3	8202	broad.mit.edu	37	20	46267869	46267869	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-A6DB-01A-11D-A30E-08	TCGA-BA-A6DB-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	041344f2-1b9f-4679-aa68-cc4b7c4b1c16	5ffe305e-72e6-46e1-be69-b42dca5ab179	g.chr20:46267869C>T	ENST00000372004.3	+	14	2846	c.2630C>T	c.(2629-2631)cCc>cTc	p.P877L	NCOA3_ENST00000341724.6_Intron|NCOA3_ENST00000371997.3_Missense_Mutation_p.P887L|NCOA3_ENST00000371998.3_Missense_Mutation_p.P877L	NM_001174087.1|NM_001174088.1|NM_006534.3|NM_181659.2	NP_001167558.1|NP_001167559.1|NP_006525.2|NP_858045.1	Q9Y6Q9	NCOA3_HUMAN	nuclear receptor coactivator 3	877					androgen receptor signaling pathway|cellular lipid metabolic process|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleoplasm	androgen receptor binding|histone acetyltransferase activity|ligand-dependent nuclear receptor binding|protein N-terminus binding|signal transducer activity|thyroid hormone receptor binding			breast(3)|endometrium(3)|kidney(4)|large_intestine(12)|lung(19)|ovary(4)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	52						AGTGCTTTCCCCATGTTACCA	0.428000													12	112					0	0	1	0	0
ETV3L	440695	broad.mit.edu	37	1	157068581	157068581	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-A6DB-01A-11D-A30E-08	TCGA-BA-A6DB-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	041344f2-1b9f-4679-aa68-cc4b7c4b1c16	5ffe305e-72e6-46e1-be69-b42dca5ab179	g.chr1:157068581G>A	ENST00000454449.2	-	3	687	c.403C>T	c.(403-405)Cgg>Tgg	p.R135W		NM_001004341.2	NP_001004341.1	Q6ZN32	ETV3L_HUMAN	ets variant 3-like	135						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(9)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	24	Hepatocellular(266;0.158)	Prostate(1639;0.184)				GGCGGCGCCCGCACTTCCCAC	0.577000													4	143					0	0	1	0	0
NLRP12	91662	broad.mit.edu	37	19	54313442	54313442	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-A6DB-01A-11D-A30E-08	TCGA-BA-A6DB-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	041344f2-1b9f-4679-aa68-cc4b7c4b1c16	5ffe305e-72e6-46e1-be69-b42dca5ab179	g.chr19:54313442C>T	ENST00000324134.6	-	3	1639	c.1471G>A	c.(1471-1473)Gtc>Atc	p.V491I	NLRP12_ENST00000535162.1_Missense_Mutation_p.V491I|NLRP12_ENST00000354278.3_Missense_Mutation_p.V491I|NLRP12_ENST00000345770.5_Missense_Mutation_p.V491I|NLRP12_ENST00000391772.1_Missense_Mutation_p.V491I|NLRP12_ENST00000391773.1_Missense_Mutation_p.V491I|NLRP12_ENST00000391775.3_Missense_Mutation_p.V491I|NLRP12_ENST00000351894.4_Missense_Mutation_p.V491I	NM_001277126.1|NM_144687.2	NP_001264055.1|NP_653288.1	P59046	NAL12_HUMAN	NLR family, pyrin domain containing 12	491	NACHT.				negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of interleukin-1 secretion|negative regulation of interleukin-6 biosynthetic process|negative regulation of protein autophosphorylation|negative regulation of Toll signaling pathway|positive regulation of inflammatory response|positive regulation of interleukin-1 beta secretion|regulation of interleukin-18 biosynthetic process|release of cytoplasmic sequestered NF-kappaB	cytoplasm	ATP binding|caspase activator activity|protein binding	p.V491I(1)		NS(1)|breast(4)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|liver(1)|lung(36)|ovary(5)|pancreas(2)|skin(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	80	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.026)		AAGGCAGAGACGTCTTCCCCG	0.512000													4	161					0	0	1	0	0
ZFHX3	463	broad.mit.edu	37	16	72821618	72821618	+	Silent	SNP	A	A	G	rs112443847		TCGA-BA-A6DB-01A-11D-A30E-08	TCGA-BA-A6DB-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	041344f2-1b9f-4679-aa68-cc4b7c4b1c16	5ffe305e-72e6-46e1-be69-b42dca5ab179	g.chr16:72821618A>G	ENST00000268489.5	-	10	11229	c.10557T>C	c.(10555-10557)ggT>ggC	p.G3519G	ZFHX3_ENST00000397992.5_Silent_p.G2605G|AC004943.1_ENST00000584072.1_RNA	NM_006885.3	NP_008816.3	Q15911	ZFHX3_HUMAN	zinc finger homeobox 3	3519	Poly-Gly.				muscle organ development|negative regulation of myoblast differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|positive regulation of myoblast differentiation	transcription factor complex	enzyme binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|zinc ion binding	p.G3519G(3)		NS(3)|breast(7)|cervix(2)|endometrium(18)|haematopoietic_and_lymphoid_tissue(5)|kidney(8)|large_intestine(22)|liver(1)|lung(46)|ovary(5)|pancreas(1)|prostate(15)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(11)	153		Ovarian(137;0.13)				cgccgccgccaccgccgccgc	0.716000													4	44					0	0	1	0	0
PAGE1	8712	broad.mit.edu	37	X	49454129	49454129	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-A6DB-01A-11D-A30E-08	TCGA-BA-A6DB-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	041344f2-1b9f-4679-aa68-cc4b7c4b1c16	5ffe305e-72e6-46e1-be69-b42dca5ab179	g.chrX:49454129C>T	ENST00000376150.3	-	5	442	c.310G>A	c.(310-312)Gat>Aat	p.D104N		NM_003785.3	NP_003776.2	O75459	GAGB1_HUMAN	P antigen family, member 1 (prostate associated)	104					cellular defense response					endometrium(1)|large_intestine(2)|lung(2)|skin(1)|urinary_tract(1)	7	Ovarian(276;0.236)					TCCTGGCTATCCGCTTCAGGC	0.363000													11	125					0	0	1	0	0
SLAMF6	114836	broad.mit.edu	37	1	160466091	160466091	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-A6DB-01A-11D-A30E-08	TCGA-BA-A6DB-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	041344f2-1b9f-4679-aa68-cc4b7c4b1c16	5ffe305e-72e6-46e1-be69-b42dca5ab179	g.chr1:160466091C>G	ENST00000368059.3	-	2	211	c.142G>C	c.(142-144)Gag>Cag	p.E48Q	SLAMF6_ENST00000368057.3_Missense_Mutation_p.E48Q|SLAMF6_ENST00000368055.1_Intron	NM_001184714.1|NM_001184715.1|NM_001184716.1|NM_052931.4	NP_001171643.1|NP_001171644.1|NP_001171645.1|NP_443163.1	Q96DU3	SLAF6_HUMAN	SLAM family member 6	48						integral to membrane|plasma membrane	receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(8)|ovary(1)|pancreas(1)|skin(4)	22	all_cancers(52;1.05e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.0923)			TTGACCTTCTCTCCTGCAGGA	0.453000													13	261					0	0	1	0	0
IGKV1-9	28941	broad.mit.edu	37	2	89309575	89309575	+	RNA	SNP	G	G	A			TCGA-BA-A6DB-01A-11D-A30E-08	TCGA-BA-A6DB-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	041344f2-1b9f-4679-aa68-cc4b7c4b1c16	5ffe305e-72e6-46e1-be69-b42dca5ab179	g.chr2:89309575G>A	ENST00000493819.1	-	0	312																											ATCCACTGCCGCTGAACCTTG	0.478000													5	310					0	0	1	0	0
PRCP	5547	broad.mit.edu	37	11	82536060	82536060	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-A6DB-01A-11D-A30E-08	TCGA-BA-A6DB-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	041344f2-1b9f-4679-aa68-cc4b7c4b1c16	5ffe305e-72e6-46e1-be69-b42dca5ab179	g.chr11:82536060C>T	ENST00000313010.3	-	9	1573	c.1379G>A	c.(1378-1380)cGc>cAc	p.R460H	PRCP_ENST00000535099.1_Missense_Mutation_p.R355H|PRCP_ENST00000393399.2_Missense_Mutation_p.R481H|PRCP_ENST00000525772.1_5'UTR	NM_005040.2	NP_005031.1	P42785	PCP_HUMAN	prolylcarboxypeptidase (angiotensinase C)	460					blood coagulation, intrinsic pathway|proteolysis	lysosome|plasma membrane	protein binding|serine-type carboxypeptidase activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(7)|prostate(1)|skin(2)|urinary_tract(1)	17						ATTCTTGGTGCGGAGATCTAA	0.502000													6	51					0	0	1	0	0
TLR9	54106	broad.mit.edu	37	3	52257252	52257252	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-A6DB-01A-11D-A30E-08	TCGA-BA-A6DB-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	041344f2-1b9f-4679-aa68-cc4b7c4b1c16	5ffe305e-72e6-46e1-be69-b42dca5ab179	g.chr3:52257252G>A	ENST00000494383.1	-	5	1539	c.1540C>T	c.(1540-1542)Cgg>Tgg	p.R514W	TLR9_ENST00000360658.2_Silent_p.F360F|TLR9_ENST00000597542.1_Silent_p.F384F			Q9NR96	TLR9_HUMAN	toll-like receptor 9	0					defense response to bacterium|fibroblast growth factor receptor signaling pathway|I-kappaB phosphorylation|inflammatory response|innate immune response|insulin receptor signaling pathway|maintenance of gastrointestinal epithelium|negative regulation of interleukin-6 production|negative regulation of interleukin-8 production|negative regulation of NF-kappaB transcription factor activity|negative regulation of toll-like receptor signaling pathway|positive regulation of chemokine production|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of interferon-beta production|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-10 production|positive regulation of interleukin-12 production|positive regulation of interleukin-18 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of JUN kinase activity|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of toll-like receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|response to molecule of bacterial origin	apical plasma membrane|basolateral plasma membrane|early phagosome|endoplasmic reticulum membrane|endosome membrane|extracellular region|integral to membrane|lysosome	interleukin-1 receptor binding|siRNA binding|transmembrane receptor activity			endometrium(4)|large_intestine(11)|lung(9)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	30				BRCA - Breast invasive adenocarcinoma(193;2.41e-05)|Kidney(197;0.000537)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)	Chloroquine(DB00608)	CCAGGCTCCCGAAGGAAGGGG	0.612000													4	113					0	0	1	0	0
EGFL7	51162	broad.mit.edu	37	9	139563123	139563123	+	Silent	SNP	C	C	T			TCGA-BA-A6DB-01A-11D-A30E-08	TCGA-BA-A6DB-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	041344f2-1b9f-4679-aa68-cc4b7c4b1c16	5ffe305e-72e6-46e1-be69-b42dca5ab179	g.chr9:139563123C>T	ENST00000371699.1	+	4	1106	c.195C>T	c.(193-195)taC>taT	p.Y65Y	EGFL7_ENST00000371698.3_Silent_p.Y65Y|EGFL7_ENST00000492002.1_3'UTR|EGFL7_ENST00000308874.7_Silent_p.Y65Y|EGFL7_ENST00000406555.3_Silent_p.Y65Y			Q9UHF1	EGFL7_HUMAN	EGF-like-domain, multiple 7	65	EMI.				angiogenesis|vasculogenesis		calcium ion binding			kidney(2)|ovary(1)|prostate(2)|urinary_tract(1)	6	all_cancers(76;0.109)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;9.87e-06)|Epithelial(140;0.000123)		GCAGCACCTACCGGTGAGTGC	0.687000													4	147					0	0	1	0	0
RGPD8	727851	broad.mit.edu	37	2	113127775	113127775	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-A6DB-01A-11D-A30E-08	TCGA-BA-A6DB-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	041344f2-1b9f-4679-aa68-cc4b7c4b1c16	5ffe305e-72e6-46e1-be69-b42dca5ab179	g.chr2:113127775G>C	ENST00000302558.3	-	23	5469	c.5278C>G	c.(5278-5280)Cct>Gct	p.P1760A	RGPD8_ENST00000409750.1_Missense_Mutation_p.P1620A	NM_001164463.1	NP_001157935.1			RANBP2-like and GRIP domain containing 8									p.P1760A(12)		endometrium(4)|kidney(1)|lung(1)|prostate(3)|urinary_tract(1)	10						GAACGGGAAGGATTTTCTTCC	0.308000													4	27					0	0	1	0	0
KRTAP4-11	653240	broad.mit.edu	37	17	39274087	39274087	+	Missense_Mutation	SNP	G	G	C	rs141357429	by1000genomes	TCGA-BA-A6DB-01A-11D-A30E-08	TCGA-BA-A6DB-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	041344f2-1b9f-4679-aa68-cc4b7c4b1c16	5ffe305e-72e6-46e1-be69-b42dca5ab179	g.chr17:39274087G>C	ENST00000391413.2	-	1	519	c.481C>G	c.(481-483)Ctg>Gtg	p.L161V		NM_033059.3	NP_149048.2	Q9BYQ6	KR411_HUMAN	keratin associated protein 4-11	161	27 X 5 AA repeats of C-C-[GIKRQVHEL]- [SPTR]-[STVQRMC].					keratin filament		p.L161V(1)		endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|lung(8)|prostate(5)|skin(1)	33		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000371)			ACTGGACGCAGGcagcagcag	0.657000													3	25					0	0	1	0	0
TYR	7299	broad.mit.edu	37	11	88911771	88911771	+	Missense_Mutation	SNP	G	G	A	rs61754365		TCGA-BA-A6DB-01A-11D-A30E-08	TCGA-BA-A6DB-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	041344f2-1b9f-4679-aa68-cc4b7c4b1c16	5ffe305e-72e6-46e1-be69-b42dca5ab179	g.chr11:88911771G>A	ENST00000263321.5	+	1	1152	c.650G>A	c.(649-651)cGg>cAg	p.R217Q	TYR_ENST00000526139.1_3'UTR	NM_000372.4	NP_000363.1	P14679	TYRO_HUMAN	tyrosinase	217			Missing (in OCA1A).|R -> G (in OCA1A).|R -> Q (in OCA1A).|R -> S (in OCA1A).|R -> W (in OCA1A).		eye pigment biosynthetic process|melanin biosynthetic process from tyrosine|visual perception	Golgi-associated vesicle|integral to membrane|lysosome|melanosome membrane|perinuclear region of cytoplasm	copper ion binding|monophenol monooxygenase activity|protein heterodimerization activity|protein homodimerization activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(25)|ovary(2)|pancreas(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	48		Acute lymphoblastic leukemia(157;2.33e-05)|all_hematologic(158;0.0033)			Azelaic Acid(DB00548)|Mimosine(DB01055)|NADH(DB00157)	TTCTTGTTGCGGTGGGAACAA	0.463000													4	172					0	0	1	0	0
MGAT5B	146664	broad.mit.edu	37	17	74928764	74928764	+	Silent	SNP	C	C	T	rs141461687	byFrequency	TCGA-BA-A6DB-01A-11D-A30E-08	TCGA-BA-A6DB-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	041344f2-1b9f-4679-aa68-cc4b7c4b1c16	5ffe305e-72e6-46e1-be69-b42dca5ab179	g.chr17:74928764C>T	ENST00000569840.2	+	11	1903	c.1329C>T	c.(1327-1329)tcC>tcT	p.S443S	MGAT5B_ENST00000428789.2_Silent_p.S454S|MGAT5B_ENST00000301618.4_Silent_p.S443S	NM_001199172.1	NP_001186101.1	Q3V5L5	MGT5B_HUMAN	mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase, isozyme B	443						Golgi membrane|integral to membrane	alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase activity|metal ion binding			breast(1)|endometrium(4)|kidney(1)|large_intestine(2)|lung(15)|ovary(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29						GCTTCGTGTCCGAGGAGCTCA	0.622000													19	121					0	0	1	0	0
ARMC9	80210	broad.mit.edu	37	2	232127058	232127058	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-A6DB-01A-11D-A30E-08	TCGA-BA-A6DB-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	041344f2-1b9f-4679-aa68-cc4b7c4b1c16	5ffe305e-72e6-46e1-be69-b42dca5ab179	g.chr2:232127058G>A	ENST00000349938.4	+	12	1260	c.1066G>A	c.(1066-1068)Gtt>Att	p.V356I	ARMC9_ENST00000483477.1_3'UTR	NM_001271466.1|NM_025139.3	NP_001258395.1|NP_079415.3	Q7Z3E5	ARMC9_HUMAN	armadillo repeat containing 9	356							binding			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(5)|ovary(2)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	22		Renal(207;0.0112)|all_lung(227;0.0744)|all_hematologic(139;0.0749)|Acute lymphoblastic leukemia(138;0.167)|Medulloblastoma(418;0.184)|Lung NSC(271;0.205)		Epithelial(121;1.43e-10)|LUSC - Lung squamous cell carcinoma(224;0.017)|Lung(119;0.0189)		GAGGGAGACCGTTCTGCAAGC	0.493000													4	120					0	0	1	0	0
RFPL4B	442247	broad.mit.edu	37	6	112671339	112671339	+	Silent	SNP	C	C	T			TCGA-BA-A6DB-01A-11D-A30E-08	TCGA-BA-A6DB-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	041344f2-1b9f-4679-aa68-cc4b7c4b1c16	5ffe305e-72e6-46e1-be69-b42dca5ab179	g.chr6:112671339C>T	ENST00000441065.2	+	3	741	c.429C>T	c.(427-429)tcC>tcT	p.S143S		NM_001013734.2	NP_001013756.2	Q6ZWI9	RFPLB_HUMAN	ret finger protein-like 4B	143	B30.2/SPRY.						zinc ion binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(8)|skin(1)	14		all_cancers(87;9.44e-05)|all_hematologic(75;0.000114)|all_epithelial(87;0.00265)|Colorectal(196;0.0209)		all cancers(137;0.0202)|OV - Ovarian serous cystadenocarcinoma(136;0.0477)|Epithelial(106;0.0646)|GBM - Glioblastoma multiforme(226;0.0866)|BRCA - Breast invasive adenocarcinoma(108;0.244)		GCTTCTCCTCCGGCCAACATT	0.532000													7	76					0	0	1	0	0
ZNF227	7770	broad.mit.edu	37	19	44739946	44739946	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-A6DB-01A-11D-A30E-08	TCGA-BA-A6DB-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	041344f2-1b9f-4679-aa68-cc4b7c4b1c16	5ffe305e-72e6-46e1-be69-b42dca5ab179	g.chr19:44739946C>T	ENST00000313040.7	+	6	1568	c.1363C>T	c.(1363-1365)Cgg>Tgg	p.R455W	ZNF227_ENST00000589005.1_Missense_Mutation_p.R404W|ZNF227_ENST00000391961.2_Missense_Mutation_p.R404W	NM_182490.1	NP_872296.1	Q86WZ6	ZN227_HUMAN	zinc finger protein 227	455					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|kidney(3)|large_intestine(4)|lung(12)|ovary(2)|stomach(1)|urinary_tract(1)	24		Prostate(69;0.0435)				AATATGCCATCGGAGAGTCCA	0.468000													4	154					0	0	1	0	0
PAK7	57144	broad.mit.edu	37	20	9561503	9561503	+	Silent	SNP	C	C	T			TCGA-BA-A6DB-01A-11D-A30E-08	TCGA-BA-A6DB-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	041344f2-1b9f-4679-aa68-cc4b7c4b1c16	5ffe305e-72e6-46e1-be69-b42dca5ab179	g.chr20:9561503C>T	ENST00000378429.3	-	5	825	c.279G>A	c.(277-279)tcG>tcA	p.S93S	PAK7_ENST00000378423.1_Silent_p.S93S|PAK7_ENST00000353224.5_Silent_p.S93S	NM_020341.3	NP_065074.1	Q9P286	PAK7_HUMAN	p21 protein (Cdc42/Rac)-activated kinase 7	93	Linker.						ATP binding|protein binding|protein serine/threonine kinase activity			NS(1)|central_nervous_system(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(44)|ovary(2)|skin(13)|stomach(1)|upper_aerodigestive_tract(3)	81			COAD - Colon adenocarcinoma(9;0.194)			AGCGAGTCACCGAGATGTTGT	0.512000													5	271					0	0	1	0	0
SACS	26278	broad.mit.edu	37	13	23939316	23939316	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-A6DB-01A-11D-A30E-08	TCGA-BA-A6DB-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	041344f2-1b9f-4679-aa68-cc4b7c4b1c16	5ffe305e-72e6-46e1-be69-b42dca5ab179	g.chr13:23939316G>A	ENST00000382298.3	-	6	1034	c.446C>T	c.(445-447)gCg>gTg	p.A149V	SACS_ENST00000402364.1_5'UTR|SACS_ENST00000382292.3_Missense_Mutation_p.A149V	NM_014363.4	NP_055178.3	Q9NZJ4	SACS_HUMAN	spastic ataxia of Charlevoix-Saguenay (sacsin)	149					cell death|negative regulation of inclusion body assembly|protein folding	axon|cell body fiber|dendrite|mitochondrion|nucleus	ATP binding|chaperone binding|Hsp70 protein binding|proteasome binding			NS(1)|biliary_tract(1)|breast(3)|central_nervous_system(2)|endometrium(22)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(54)|lung(49)|ovary(7)|pancreas(1)|prostate(4)|skin(10)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(11)	189		all_cancers(29;1.51e-22)|all_epithelial(30;7.82e-19)|all_lung(29;4.71e-18)|Lung SC(185;0.0225)|Breast(139;0.128)		all cancers(112;0.00197)|Epithelial(112;0.00854)|OV - Ovarian serous cystadenocarcinoma(117;0.0298)|Lung(94;0.189)		CTGATATGGCGCCATATCTTT	0.328000													4	49					0	0	1	0	0
RP11-439I14.2	0	broad.mit.edu	37	16	64770704	64770705	+	RNA	INS	-	-	CCAGTGATGGTCACCT	rs140029302	by1000genomes	TCGA-BA-A6DB-01A-11D-A30E-08	TCGA-BA-A6DB-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	041344f2-1b9f-4679-aa68-cc4b7c4b1c16	5ffe305e-72e6-46e1-be69-b42dca5ab179	g.chr16:64770704_64770705insCCAGTGATGGTCACCT	ENST00000564293.1	+	0	453_454																											TGTCACCACTGCCACCTTGTTC	0.371													4	8	---	---	---	---					
SERHL	94009	broad.mit.edu	37	22	42898665	42898666	+	RNA	INS	-	-	C			TCGA-BA-A6DB-01A-11D-A30E-08	TCGA-BA-A6DB-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	041344f2-1b9f-4679-aa68-cc4b7c4b1c16	5ffe305e-72e6-46e1-be69-b42dca5ab179	g.chr22:42898665_42898666insC	ENST00000359906.2	+	0	409					NR_027786.1				serine hydrolase-like											endometrium(1)|large_intestine(1)	2						CCCATATGGTGCCCCCCCCCCA	0.589													2	4	---	---	---	---