Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
OR4D11	219986	broad.mit.edu	37	11	59271552	59271552	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr11:59271552C>A	ENST00000313253.1	+	1	504	c.504C>A	c.(502-504)ttC>ttA	p.F168L		NM_001004706.1	NP_001004706.1	Q8NGI4	OR4DB_HUMAN	olfactory receptor, family 4, subfamily D, member 11	168					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|large_intestine(3)|liver(2)|lung(17)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	29						CTCTCCCTTTCTGTGGACCCA	0.512000													19	80					1.40151e-16	5.61321e-15	0.000175454	1	0
SALL1	6299	broad.mit.edu	37	16	51173271	51173271	+	Silent	SNP	G	G	A			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr16:51173271G>A	ENST00000440970.1	-	2	3002	c.2571C>T	c.(2569-2571)agC>agT	p.S857S	SALL1_ENST00000541611.1_Intron|SALL1_ENST00000251020.4_Silent_p.S954S|SALL1_ENST00000566102.1_Intron	NM_001127892.1	NP_001121364.1	Q9NSC2	SALL1_HUMAN	spalt-like transcription factor 1	954					adrenal gland development|branching involved in ureteric bud morphogenesis|embryonic digestive tract development|embryonic digit morphogenesis|gonad development|histone deacetylation|inductive cell-cell signaling|mesenchymal to epithelial transition involved in metanephros morphogenesis|negative regulation of transcription from RNA polymerase II promoter|olfactory bulb interneuron differentiation|olfactory bulb mitral cell layer development|olfactory nerve development|outer ear morphogenesis|pituitary gland development|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway|ureteric bud invasion|ventricular septum development	chromocenter|cytoplasm|heterochromatin|nucleus	beta-catenin binding|DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.S954S(1)		NS(4)|breast(2)|central_nervous_system(2)|endometrium(3)|kidney(5)|large_intestine(25)|lung(61)|ovary(3)|prostate(6)|skin(12)|upper_aerodigestive_tract(3)	126		all_cancers(37;0.0322)	COAD - Colon adenocarcinoma(2;0.24)			TGGCAAACTCGCTTGGGACCG	0.517000													13	22					0	0	0.000151284	0	0
TUBG1	7283	broad.mit.edu	37	17	40766632	40766632	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr17:40766632G>A	ENST00000251413.3	+	10	1177	c.1115G>A	c.(1114-1116)cGg>cAg	p.R372Q		NM_001070.4	NP_001061.2	P23258	TBG1_HUMAN	tubulin, gamma 1	372					G2/M transition of mitotic cell cycle|meiotic spindle organization|protein polymerization	condensed nuclear chromosome|cytosol|gamma-tubulin complex|polar microtubule	GTP binding|GTPase activity|protein binding|structural constituent of cytoskeleton			endometrium(2)|kidney(2)|large_intestine(2)|lung(4)|ovary(1)|prostate(1)	12		Breast(137;0.00116)		BRCA - Breast invasive adenocarcinoma(366;0.129)		TCGGCCCACCGGGTCAGCGGG	0.592000													15	45					0	0	0.000175454	0	0
ZNF577	84765	broad.mit.edu	37	19	52383578	52383578	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr19:52383578C>G	ENST00000420592.1	-	3	1391	c.58G>C	c.(58-60)Gag>Cag	p.E20Q	ZNF577_ENST00000301399.5_Missense_Mutation_p.E20Q|ZNF577_ENST00000451628.2_Missense_Mutation_p.E20Q|ZNF577_ENST00000485702.1_Intron|ZNF577_ENST00000412216.1_Missense_Mutation_p.E20Q			Q9BSK1	ZN577_HUMAN	zinc finger protein 577	0					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|kidney(1)|large_intestine(5)|lung(9)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	21		all_neural(266;0.0602)		GBM - Glioblastoma multiforme(134;0.00161)|OV - Ovarian serous cystadenocarcinoma(262;0.019)		aaatttacctcccctgaagaa	0.423000													22	110					0	0	0.000117367	0	0
METTL25	84190	broad.mit.edu	37	12	82870447	82870447	+	Missense_Mutation	SNP	T	T	A			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr12:82870447T>A	ENST00000248306.3	+	10	1666	c.1597T>A	c.(1597-1599)Tac>Aac	p.Y533N		NM_032230.2	NP_115606.2			methyltransferase like 25																		TATAATGAACTACTACGAGAA	0.284000													18	95					0	0	9.7654e-05	0	0
CUBN	8029	broad.mit.edu	37	10	16870832	16870832	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr10:16870832G>A	ENST00000377833.4	-	66	10801	c.10736C>T	c.(10735-10737)tCt>tTt	p.S3579F		NM_001081.3	NP_001072.2	O60494	CUBN_HUMAN	cubilin (intrinsic factor-cobalamin receptor)	3579	CUB 27.				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			breast(8)|central_nervous_system(4)|cervix(1)|endometrium(18)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(42)|liver(1)|lung(107)|ovary(9)|pancreas(2)|prostate(3)|skin(9)|stomach(3)|upper_aerodigestive_tract(11)|urinary_tract(8)	241					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	AGAGGATGGAGAGCTGGCGTT	0.433000											OREG0020047	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	6	37					0	0	8.12818e-05	0	0
AK7	122481	broad.mit.edu	37	14	96864496	96864496	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr14:96864496C>A	ENST00000267584.4	+	2	234	c.190C>A	c.(190-192)Ctg>Atg	p.L64M	AK7_ENST00000555570.1_Missense_Mutation_p.L64M	NM_152327.3	NP_689540.2	Q96M32	KAD7_HUMAN	adenylate kinase 7	64					cell projection organization	cytosol	adenylate kinase activity|ATP binding|cytidylate kinase activity			breast(2)|cervix(2)|endometrium(3)|large_intestine(8)|lung(11)|ovary(1)|prostate(2)|skin(1)|urinary_tract(1)	31		all_cancers(154;0.0482)|all_epithelial(191;0.128)|Melanoma(154;0.155)		Epithelial(152;0.134)|COAD - Colon adenocarcinoma(157;0.228)		GTCAGCTATGCTGGAAGCTTC	0.488000													13	72					1.3612e-06	4.94594e-05	0.000308642	1	0
DDHD1	80821	broad.mit.edu	37	14	53527915	53527915	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr14:53527915T>C	ENST00000357758.3	-	8	1954	c.1771A>G	c.(1771-1773)Aag>Gag	p.K591E	DDHD1_ENST00000323669.5_Missense_Mutation_p.K591E|DDHD1_ENST00000395606.1_Missense_Mutation_p.K598E	NM_030637.2	NP_085140.2	Q8NEL9	DDHD1_HUMAN	DDHD domain containing 1	591					lipid catabolic process	cytoplasm	hydrolase activity|metal ion binding			breast(2)|cervix(1)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(4)|lung(11)|ovary(3)|prostate(1)	25	Breast(41;0.037)					TCTATTTCCTTCAGCCTAAGA	0.348000													15	79					0	0	5.01169e-05	0	0
LILRA6	79168	broad.mit.edu	37	19	54746049	54746049	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr19:54746049C>A	ENST00000440558.2	-	3	256	c.208G>T	c.(208-210)Gac>Tac	p.D70Y	LILRA6_ENST00000396365.2_Missense_Mutation_p.D70Y|LILRA6_ENST00000245621.5_Missense_Mutation_p.D70Y|LILRA6_ENST00000391735.3_Missense_Mutation_p.D70Y|LILRA6_ENST00000270464.5_Missense_Mutation_p.D70Y|LILRB3_ENST00000407860.2_Missense_Mutation_p.D70Y|LILRA6_ENST00000419410.2_Missense_Mutation_p.D70Y					leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6											central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(4)|lung(20)|ovary(3)|skin(2)|urinary_tract(2)	38	all_cancers(19;0.00723)|all_epithelial(19;0.00389)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		TTATTTCTGTCCAAGGGCTCT	0.567000													18	147					2.98393e-07	1.10124e-05	0.000375601	1	0
KIF4B	285643	broad.mit.edu	37	5	154394225	154394225	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr5:154394225G>A	ENST00000435029.4	+	1	966	c.806G>A	c.(805-807)tGc>tAc	p.C269Y		NM_001099293.1	NP_001092763.1	Q2VIQ3	KIF4B_HUMAN	kinesin family member 4B	269	Kinesin-motor.				axon guidance|blood coagulation|microtubule-based movement	cytosol|microtubule|nuclear matrix	ATP binding|DNA binding|microtubule motor activity			breast(1)|central_nervous_system(1)|endometrium(7)|kidney(6)|large_intestine(13)|lung(27)|ovary(2)|upper_aerodigestive_tract(1)	58	Renal(175;0.00488)	Medulloblastoma(196;0.0523)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)			GGCCTCCTATGCTTGGGAAAT	0.443000													15	58					0	0	0.000308642	0	0
NEFH	4744	broad.mit.edu	37	22	29885318	29885318	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr22:29885318G>T	ENST00000310624.6	+	4	1722	c.1689G>T	c.(1687-1689)gaG>gaT	p.E563D		NM_021076.3	NP_066554.2	P12036	NFH_HUMAN	neurofilament, heavy polypeptide	563	30 X 6 AA repeats of K-S-P-[AEPV]-[EAK]- [AEVK].|Tail.				cell death|nervous system development	neurofilament				cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(12)|ovary(2)|skin(3)	30						CACCGCCTGAGGCCAAGTCCC	0.572000													6	39					2.0095e-06	7.19033e-05	8.12818e-05	1	0
CRY1	1407	broad.mit.edu	37	12	107395137	107395137	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr12:107395137G>T	ENST00000008527.5	-	5	1472	c.605C>A	c.(604-606)aCa>aAa	p.T202K		NM_004075.3	NP_004066.1	Q16526	CRY1_HUMAN	cryptochrome 1 (photolyase-like)	202					DNA repair|protein-chromophore linkage|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	blue light photoreceptor activity|DNA photolyase activity|double-stranded DNA binding|nucleotide binding|protein binding			NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(11)|ovary(3)|skin(1)	29						TAAGCCATCTGTATCAAAACC	0.343000													5	73					0.000274275	0.0086698	0.000274275	1	0
MYOF	26509	broad.mit.edu	37	10	95072788	95072788	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr10:95072788G>C	ENST00000371501.4	-	51	6000	c.5878C>G	c.(5878-5880)Cgc>Ggc	p.R1960G	MYOF_ENST00000359263.4_Missense_Mutation_p.R1960G|MYOF_ENST00000371502.4_Missense_Mutation_p.R1950G|MYOF_ENST00000358334.5_Missense_Mutation_p.R1947G			Q9NZM1	MYOF_HUMAN	myoferlin	1960					blood circulation|muscle contraction|plasma membrane repair	caveola|cytoplasmic vesicle membrane|integral to membrane|nuclear membrane	phospholipid binding|protein binding			NS(2)|autonomic_ganglia(1)|breast(3)|endometrium(7)|kidney(7)|large_intestine(15)|lung(14)|ovary(4)|prostate(4)|skin(6)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	67						GCCATTACGCGGGCGCCATCT	0.458000													6	293					0	0	0.000157383	0	0
GPR98	84059	broad.mit.edu	37	5	90004696	90004696	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr5:90004696G>T	ENST00000405460.2	+	39	8890	c.8794G>T	c.(8794-8796)Gct>Tct	p.A2932S		NM_032119.3	NP_115495.3	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98	2932					cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(4)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(18)|large_intestine(46)|liver(2)|lung(80)|ovary(12)|pancreas(5)|prostate(1)|skin(50)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(6)	269		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		ACTTACCATGGCTGCTTCAAC	0.343000													32	52					6.05902e-23	2.4546e-21	0.000109025	1	0
PTPRM	5797	broad.mit.edu	37	18	8143677	8143677	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr18:8143677G>A	ENST00000332175.8	+	14	3237	c.2200G>A	c.(2200-2202)Gag>Aag	p.E734K	PTPRM_ENST00000444013.1_Missense_Mutation_p.E521K|PTPRM_ENST00000400053.4_Missense_Mutation_p.E672K|PTPRM_ENST00000580170.1_Missense_Mutation_p.E734K|PTPRM_ENST00000400060.4_Missense_Mutation_p.E734K	NM_002845.3	NP_002836.3	P28827	PTPRM_HUMAN	protein tyrosine phosphatase, receptor type, M	734					homophilic cell adhesion|negative regulation of angiogenesis|negative regulation of endothelial cell migration|negative regulation of endothelial cell proliferation|response to drug|retina layer formation|retinal ganglion cell axon guidance	cell-cell adherens junction|integral to plasma membrane|lamellipodium|perinuclear region of cytoplasm	cadherin binding|transmembrane receptor protein tyrosine phosphatase activity			breast(3)|central_nervous_system(1)|cervix(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(32)|lung(25)|ovary(2)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	90		Colorectal(10;0.234)				CCCAGAACCCGAGAAACAGAC	0.423000													12	60					0	0	0.000151284	0	0
PCDHA7	56141	broad.mit.edu	37	5	140216085	140216085	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr5:140216085C>T	ENST00000525929.1	+	1	2117	c.2117C>T	c.(2116-2118)gCg>gTg	p.A706V	PCDHA7_ENST00000378125.3_Missense_Mutation_p.A706V|PCDHA6_ENST00000527624.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA4_ENST00000512229.2_Intron	NM_018910.2	NP_061733.1														NS(2)|biliary_tract(1)|breast(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(27)|ovary(3)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	63			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCCATCTGCGCGGTGTCCAGT	0.617000													7	19					0	0	6.40141e-05	0	0
LARP1	23367	broad.mit.edu	37	5	154179306	154179306	+	Silent	SNP	C	C	T			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr5:154179306C>T	ENST00000336314.4	+	9	1326	c.1302C>T	c.(1300-1302)taC>taT	p.Y434Y		NM_015315.3	NP_056130.2	Q6PKG0	LARP1_HUMAN	La ribonucleoprotein domain family, member 1	511	HTH La-type RNA-binding.						protein binding|RNA binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(10)|lung(9)|ovary(3)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	33	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.147)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)			GTCAGCACTACCAAAAGGAGA	0.527000													18	26					0	0	9.7654e-05	0	0
SECISBP2	79048	broad.mit.edu	37	9	91963071	91963071	+	Silent	SNP	C	C	T			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr9:91963071C>T	ENST00000375807.3	+	12	1751	c.1680C>T	c.(1678-1680)gaC>gaT	p.D560D	SECISBP2_ENST00000339901.4_Silent_p.D487D|SECISBP2_ENST00000534113.2_Silent_p.D492D	NM_024077.3	NP_076982.3	Q96T21	SEBP2_HUMAN	SECIS binding protein 2	560					translation	nucleus	mRNA 3'-UTR binding			breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|liver(2)|lung(11)|ovary(3)|skin(2)	32						CCAGTGATGACACACAAGATG	0.403000													16	68					0	0	9.7654e-05	0	0
PCDH11X	27328	broad.mit.edu	37	X	91132758	91132758	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chrX:91132758C>A	ENST00000373094.1	+	2	2364	c.1519C>A	c.(1519-1521)Cct>Act	p.P507T	PCDH11X_ENST00000373088.1_Missense_Mutation_p.P507T|PCDH11X_ENST00000361655.2_Missense_Mutation_p.P507T|PCDH11X_ENST00000406881.1_Missense_Mutation_p.P507T|PCDH11X_ENST00000361724.1_Missense_Mutation_p.P507T|PCDH11X_ENST00000373097.1_Missense_Mutation_p.P507T|PCDH11X_ENST00000298274.8_Missense_Mutation_p.P507T|PCDH11X_ENST00000395337.2_Missense_Mutation_p.P507T|PCDH11X_ENST00000504220.1_Missense_Mutation_p.P507T	NM_032968.3	NP_116750.1	Q9BZA7	PC11X_HUMAN	protocadherin 11 X-linked	507	Cadherin 5.				homophilic cell adhesion	integral to plasma membrane	calcium ion binding			NS(1)|autonomic_ganglia(1)|biliary_tract(1)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(30)|liver(4)|lung(92)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	159						CCTGCTAGGCCCTGATGCTCC	0.423000													12	10					1.08611e-07	4.05078e-06	6.40141e-05	1	0
ACO2	50	broad.mit.edu	37	22	41895779	41895779	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr22:41895779G>C	ENST00000396512.3	+	2	103	c.86G>C	c.(85-87)cGg>cCg	p.R29P	ACO2_ENST00000216254.4_Missense_Mutation_p.R29P			Q99798	ACON_HUMAN	aconitase 2, mitochondrial	29					citrate metabolic process|tricarboxylic acid cycle	mitochondrial matrix|nucleus	4 iron, 4 sulfur cluster binding|aconitate hydratase activity|citrate hydro-lyase (cis-aconitate-forming) activity|iron ion binding|isocitrate hydro-lyase (cis-aconitate-forming) activity			breast(3)|endometrium(5)|large_intestine(2)|lung(6)|ovary(1)|prostate(1)|skin(2)|stomach(1)|urinary_tract(2)	23						CTGTGCCAACGGGCCAAGGTG	0.517000													4	131					0	0	0.00024832	0	0
SPOCD1	90853	broad.mit.edu	37	1	32264059	32264059	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr1:32264059C>T	ENST00000360482.2	-	8	2141	c.2012G>A	c.(2011-2013)cGg>cAg	p.R671Q	SPOCD1_ENST00000533231.1_Missense_Mutation_p.R671Q|SPOCD1_ENST00000257100.3_Missense_Mutation_p.R164Q|SPOCD1_ENST00000373648.2_3'UTR	NM_144569.4	NP_653170.3	Q6ZMY3	SPOC1_HUMAN	SPOC domain containing 1	671	TFIIS central.		R -> W (in a breast cancer sample; somatic mutation).		transcription, DNA-dependent					NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|liver(1)|lung(7)|ovary(6)|prostate(1)|skin(3)|stomach(1)|urinary_tract(2)	37		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.186)|Ovarian(437;0.199)		STAD - Stomach adenocarcinoma(196;0.18)		CCTGGGGTCCCGCAGGTTGAA	0.617000													12	21					0	0	0.00010058	0	0
IQSEC1	9922	broad.mit.edu	37	3	12977740	12977740	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr3:12977740G>A	ENST00000273221.4	-	3	1034	c.818C>T	c.(817-819)gCg>gTg	p.A273V		NM_014869.5	NP_055684.3	Q6DN90	IQEC1_HUMAN	IQ motif and Sec7 domain 1	273					regulation of ARF protein signal transduction	cytoplasm|nucleus	ARF guanyl-nucleotide exchange factor activity			breast(2)|endometrium(5)|kidney(1)|large_intestine(5)|lung(6)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	24						GGCCCGCGCCGCATCCAGGGC	0.642000													8	24					0	0	0.000274275	0	0
SMARCC1	6599	broad.mit.edu	37	3	47762163	47762163	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr3:47762163G>C	ENST00000254480.5	-	7	828	c.709C>G	c.(709-711)Cca>Gca	p.P237A	SMARCC1_ENST00000425518.1_5'UTR	NM_003074.3	NP_003065.3	Q92922	SMRC1_HUMAN	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1	237					chromatin remodeling|nervous system development|transcription, DNA-dependent	nBAF complex|npBAF complex|nucleoplasm|SWI/SNF complex|WINAC complex	DNA binding|protein N-terminus binding|transcription coactivator activity			breast(1)|endometrium(5)|kidney(2)|large_intestine(3)|lung(15)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	33				BRCA - Breast invasive adenocarcinoma(193;7.47e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.00862)|Kidney(197;0.01)		TACCTGTCTGGGTAAAAGCCC	0.363000													4	157					0	0	1.23904e-05	0	0
LMBRD2	92255	broad.mit.edu	37	5	36141228	36141228	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr5:36141228T>C	ENST00000296603.4	-	4	811	c.349A>G	c.(349-351)Acg>Gcg	p.T117A		NM_001007527.1	NP_001007528.1	Q68DH5	LMBD2_HUMAN	LMBR1 domain containing 2	117						integral to membrane				breast(2)|endometrium(4)|kidney(3)|large_intestine(7)|lung(12)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	35	all_lung(31;0.000146)		Epithelial(62;0.0396)|Lung(74;0.111)|all cancers(62;0.115)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			AATTGTGACGTCCAATACACT	0.313000													30	103					0	0	0.000339439	0	0
IP6K1	9807	broad.mit.edu	37	3	49775724	49775724	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr3:49775724G>C	ENST00000321599.4	-	3	656	c.355C>G	c.(355-357)Cgc>Ggc	p.R119G	IP6K1_ENST00000395238.1_5'UTR|IP6K1_ENST00000460540.1_5'UTR|IP6K1_ENST00000468463.1_Missense_Mutation_p.R119G	NM_001242829.1|NM_153273.3	NP_001229758.1|NP_695005.1	Q92551	IP6K1_HUMAN	inositol hexakisphosphate kinase 1	119					phosphatidylinositol phosphorylation	cytoplasm|nucleus	ATP binding|inositol hexakisphosphate 5-kinase activity|inositol trisphosphate 3-kinase activity	p.R119S(1)		breast(1)|endometrium(3)|kidney(1)|large_intestine(5)|liver(1)|lung(2)|skin(2)	15						AGGCTCCGGCGGGAGTGTTTG	0.542000													4	39					0	0	0.00024832	0	0
LRRC17	10234	broad.mit.edu	37	7	102574878	102574878	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr7:102574878C>T	ENST00000249377.4	+	2	799	c.518C>T	c.(517-519)aCg>aTg	p.T173M	FBXL13_ENST00000313221.4_Intron|FBXL13_ENST00000393772.2_Intron|FBXL13_ENST00000379308.3_Intron|FBXL13_ENST00000379305.3_Intron|FBXL13_ENST00000456695.1_Intron|LRRC17_ENST00000339431.4_Missense_Mutation_p.T173M|FBXL13_ENST00000455112.2_Intron|FBXL13_ENST00000379306.3_Intron|FBXL13_ENST00000436908.1_Intron	NM_005824.2	NP_005815.2	Q8N6Y2	LRC17_HUMAN	leucine rich repeat containing 17	173	LRRCT 1.				bone marrow development|negative regulation of osteoclast differentiation|ossification	extracellular space				NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(5)|liver(2)|lung(3)|ovary(1)|prostate(1)|urinary_tract(1)	17						GAGATAGAAACGCTTATTTCA	0.433000													12	103					0	0	0.000219431	0	0
HAVCR1	26762	broad.mit.edu	37	5	156469687	156469687	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr5:156469687T>C	ENST00000339252.3	-	5	1320	c.788A>G	c.(787-789)aAt>aGt	p.N263S	HAVCR1_ENST00000544197.1_Missense_Mutation_p.N263S|HAVCR1_ENST00000425854.1_Missense_Mutation_p.N263S|HAVCR1_ENST00000523175.1_Missense_Mutation_p.N263S|HAVCR1_ENST00000522693.1_Missense_Mutation_p.N263S|HAVCR1_ENST00000517644.1_5'UTR	NM_012206.2	NP_036338.2	Q96D42	HAVR1_HUMAN	hepatitis A virus cellular receptor 1	258					interspecies interaction between organisms	integral to membrane	receptor activity			endometrium(3)|large_intestine(2)|lung(17)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	28	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.0999)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			CACGGTGTCATTCCCATCTAC	0.353000													16	83					0	0	0.000132079	0	0
ECE1	1889	broad.mit.edu	37	1	21564651	21564651	+	Silent	SNP	G	G	A			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr1:21564651G>A	ENST00000415912.2	-	11	1442	c.1317C>T	c.(1315-1317)acC>acT	p.T439T	ECE1_ENST00000357071.4_Silent_p.T443T|ECE1_ENST00000528294.1_5'UTR|ECE1_ENST00000436918.2_Silent_p.T455T|ECE1_ENST00000264205.6_Silent_p.T452T|ECE1_ENST00000374893.6_Silent_p.T455T	NM_001113348.1	NP_001106819.1	P42892	ECE1_HUMAN	endothelin converting enzyme 1	455					bradykinin catabolic process|calcitonin catabolic process|ear development|embryonic digit morphogenesis|endothelin maturation|heart development|positive regulation of receptor recycling|substance P catabolic process	early endosome|external side of plasma membrane|integral to membrane|intrinsic to endosome membrane|membrane fraction|perinuclear region of cytoplasm|plasma membrane|Weibel-Palade body	metal ion binding|metalloendopeptidase activity|protein homodimerization activity			endometrium(5)|kidney(1)|large_intestine(7)|lung(8)|ovary(2)|prostate(1)|skin(1)	25		Lung NSC(340;1.14e-05)|all_lung(284;1.23e-05)|Colorectal(325;3.46e-05)|Renal(390;9.67e-05)|Breast(348;0.00147)|Ovarian(437;0.00432)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0183)|OV - Ovarian serous cystadenocarcinoma(117;4.83e-27)|COAD - Colon adenocarcinoma(152;1.36e-06)|GBM - Glioblastoma multiforme(114;1.47e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000162)|STAD - Stomach adenocarcinoma(196;0.00326)|KIRC - Kidney renal clear cell carcinoma(1967;0.00755)|READ - Rectum adenocarcinoma(331;0.0678)|Lung(427;0.206)		CCTCGGCGAAGGTTGCTTTGA	0.537000													8	18					0	0	0.000274275	0	0
DHCR7	1717	broad.mit.edu	37	11	71146483	71146483	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr11:71146483C>T	ENST00000355527.3	-	9	1642	c.1366G>A	c.(1366-1368)Ggc>Agc	p.G456S	DHCR7_ENST00000407721.2_Missense_Mutation_p.G456S	NM_001163817.1|NM_001360.2	NP_001157289.1|NP_001351.2	Q9UBM7	DHCR7_HUMAN	7-dehydrocholesterol reductase	456					cholesterol biosynthetic process	endoplasmic reticulum membrane|integral to membrane|nuclear outer membrane	7-dehydrocholesterol reductase activity|protein binding			endometrium(2)|kidney(1)|large_intestine(3)|liver(1)|lung(10)|ovary(1)|skin(1)	19					NADH(DB00157)	CAGTCCCGGCCGTACTTGCTG	0.657000									Smith-Lemli-Opitz syndrome				10	29					0	0	3.86212e-05	0	0
PRAMEF2	65122	broad.mit.edu	37	1	12920063	12920063	+	Missense_Mutation	SNP	A	A	G			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr1:12920063A>G	ENST00000240189.2	+	3	890	c.803A>G	c.(802-804)cAc>cGc	p.H268R		NM_023014.1	NP_075390.1	O60811	PRAM2_HUMAN	PRAME family member 2	268										breast(2)|endometrium(1)|kidney(2)|large_intestine(2)|lung(22)|prostate(6)|skin(3)|upper_aerodigestive_tract(4)	42	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.00224)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;2.4e-06)|Kidney(185;4.89e-05)|COAD - Colon adenocarcinoma(227;0.000152)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		AGGCTGGAACACCTCCAGTTG	0.463000													17	74					0	0	3.45872e-05	0	0
TRAPPC12	51112	broad.mit.edu	37	2	3405563	3405563	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr2:3405563G>C	ENST00000324266.5	+	3	1258	c.1063G>C	c.(1063-1065)Gac>Cac	p.D355H	TRAPPC12_ENST00000382110.2_Missense_Mutation_p.D355H	NM_016030.5	NP_057114.5	Q8WVT3	TTC15_HUMAN	trafficking protein particle complex 12	355							binding										TGCAGTTAAAGACTTGATGCT	0.378000													17	135					0	0	5.01169e-05	0	0
CYP4Z1	199974	broad.mit.edu	37	1	47564902	47564902	+	Missense_Mutation	SNP	A	A	G			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr1:47564902A>G	ENST00000334194.3	+	8	1016	c.1013A>G	c.(1012-1014)cAg>cGg	p.Q338R	CYP4A22-AS1_ENST00000444042.2_lincRNA	NM_178134.2	NP_835235.1	Q86W10	CP4Z1_HUMAN	cytochrome P450, family 4, subfamily Z, polypeptide 1	338						endoplasmic reticulum membrane|integral to membrane|microsome	aromatase activity|electron carrier activity|heme binding			cervix(1)|large_intestine(4)|lung(4)|skin(1)|stomach(1)	11						GAGCATCAGCAGAGATGCCGA	0.458000													3	35					0	0	0.00024832	0	0
PRSS1	5644	broad.mit.edu	37	7	142460848	142460848	+	Missense_Mutation	SNP	A	A	T	rs141554682	byFrequency	TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr7:142460848A>T	ENST00000486171.1	+	6	780	c.763A>T	c.(763-765)Aac>Tac	p.N255Y	PRSS1_ENST00000311737.7_Missense_Mutation_p.N241Y			P07477	TRY1_HUMAN	protease, serine, 1 (trypsin 1)	241					digestion|proteolysis	extracellular space	metal ion binding|protein binding|serine-type endopeptidase activity			central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(24)|prostate(2)	38	Melanoma(164;0.047)	all_cancers(3;2.14e-49)|Acute lymphoblastic leukemia(3;7.3e-185)|all_hematologic(3;1.1e-165)	all cancers(2;0.000126)|Colorectal(2;0.000157)|Epithelial(2;0.000191)|COAD - Colon adenocarcinoma(2;0.00189)			ATGGATTAAGAACACCATAGC	0.493000													7	32					0	0	8.12818e-05	0	0
ALMS1	7840	broad.mit.edu	37	2	73826530	73826530	+	Silent	SNP	A	A	G			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr2:73826530A>G	ENST00000264448.6	+	17	11658	c.11547A>G	c.(11545-11547)gtA>gtG	p.V3849V	ALMS1_ENST00000409009.1_Silent_p.V3807V	NM_015120.4	NP_055935.4	Q8TCU4	ALMS1_HUMAN	Alstrom syndrome 1	3849					G2/M transition of mitotic cell cycle	centrosome|cilium|cytosol|microtubule basal body|spindle pole				breast(4)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(31)|lung(68)|ovary(4)|pancreas(4)|prostate(3)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	147						TTTTCTAGGTAGCAAACCATG	0.368000													36	180					0	0	0.000374591	0	0
ABCC5	10057	broad.mit.edu	37	3	183663676	183663676	+	Silent	SNP	G	G	T			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr3:183663676G>T	ENST00000334444.6	-	24	3706	c.3466C>A	c.(3466-3468)Cga>Aga	p.R1156R	ABCC5_ENST00000265586.6_Silent_p.R1113R	NM_005688.2	NP_005679.2	O15440	MRP5_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 5	1156						integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of substances|organic anion transmembrane transporter activity			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(9)|lung(32)|ovary(3)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	62	all_cancers(143;1.85e-10)|Ovarian(172;0.0303)		Epithelial(37;1.74e-35)|OV - Ovarian serous cystadenocarcinoma(80;6.48e-22)			GAGGTGAATCGAGCTTCTGTC	0.448000													7	265					0.000274275	0.0086698	0.000274275	1	0
CDR2	1039	broad.mit.edu	37	16	22360714	22360714	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr16:22360714C>T	ENST00000268383.2	-	4	699	c.392G>A	c.(391-393)aGc>aAc	p.S131N		NM_001802.1	NP_001793.1	Q01850	CDR2_HUMAN	cerebellar degeneration-related protein 2, 62kDa	131						nucleus	protein binding			endometrium(3)|large_intestine(3)|lung(3)|skin(1)|urinary_tract(1)	11				GBM - Glioblastoma multiforme(48;0.0188)		CTCCACTTGGCTCTGGAGGTG	0.527000													27	60					0	0	0.000184323	0	0
CRB1	23418	broad.mit.edu	37	1	197316484	197316484	+	Missense_Mutation	SNP	G	G	A	rs148240351		TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr1:197316484G>A	ENST00000367400.3	+	4	998	c.863G>A	c.(862-864)tGc>tAc	p.C288Y	CRB1_ENST00000367399.2_Intron|CRB1_ENST00000538660.1_Missense_Mutation_p.C288Y|CRB1_ENST00000535699.1_Missense_Mutation_p.C219Y|CRB1_ENST00000543483.1_5'UTR	NM_201253.2	NP_957705.1	P82279	CRUM1_HUMAN	crumbs homolog 1 (Drosophila)	288	EGF-like 7; calcium-binding (Potential).				cell-cell signaling|establishment or maintenance of cell polarity	apical plasma membrane|extracellular region|integral to membrane	calcium ion binding|protein binding			NS(1)|breast(4)|central_nervous_system(2)|cervix(3)|endometrium(13)|kidney(4)|large_intestine(21)|lung(58)|ovary(7)|prostate(3)|skin(10)|upper_aerodigestive_tract(4)|urinary_tract(2)	132						AGCTGTAACTGCACGGGTAGT	0.388000													18	131					0	0	7.07596e-05	0	0
TNIK	23043	broad.mit.edu	37	3	170858204	170858204	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr3:170858204C>A	ENST00000436636.2	-	13	1660	c.1316G>T	c.(1315-1317)cGt>cTt	p.R439L	TNIK_ENST00000488470.1_Missense_Mutation_p.R439L|TNIK_ENST00000475336.1_Missense_Mutation_p.R439L|TNIK_ENST00000460047.1_Missense_Mutation_p.R439L|TNIK_ENST00000369326.5_Missense_Mutation_p.R439L|TNIK_ENST00000357327.5_Missense_Mutation_p.R439L|TNIK_ENST00000470834.1_Missense_Mutation_p.R439L|TNIK_ENST00000284483.8_Missense_Mutation_p.R439L|TNIK_ENST00000341852.6_Missense_Mutation_p.R439L|TNIK_ENST00000538048.1_Missense_Mutation_p.R439L	NM_015028.2	NP_055843.1	Q9UKE5	TNIK_HUMAN	TRAF2 and NCK interacting kinase	439	Mediates interaction with NEDD4.				actin cytoskeleton reorganization|activation of JNKK activity|protein autophosphorylation|regulation of dendrite morphogenesis|Wnt receptor signaling pathway	cytoskeleton|nucleus|recycling endosome	ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(14)|lung(22)|ovary(5)|pancreas(1)|prostate(4)|upper_aerodigestive_tract(2)	62	all_cancers(22;2.55e-19)|all_lung(20;2.22e-14)|Ovarian(172;0.00197)|Breast(254;0.122)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)			ATGCTCCGCACGCCTCCTCTC	0.652000													30	112					6.05902e-23	2.4546e-21	0.000109025	1	0
PTPRG	5793	broad.mit.edu	37	3	62153671	62153671	+	Silent	SNP	C	C	T			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr3:62153671C>T	ENST00000474889.1	+	8	1244	c.867C>T	c.(865-867)acC>acT	p.T289T	PTPRG_ENST00000295874.10_Silent_p.T289T	NM_002841.3	NP_002832.3	P23470	PTPRG_HUMAN	protein tyrosine phosphatase, receptor type, G	289	Alpha-carbonic anhydrase.				transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	identical protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(4)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(12)|liver(2)|lung(15)|ovary(7)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	62				BRCA - Breast invasive adenocarcinoma(55;0.000376)|KIRC - Kidney renal clear cell carcinoma(10;0.0499)|Kidney(10;0.065)		CCATCTTCACCACGGAGCAGC	0.473000													7	46					0	0	0.000274275	0	0
OR13D1	286365	broad.mit.edu	37	9	107456988	107456988	+	Nonsense_Mutation	SNP	G	G	T			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr9:107456988G>T	ENST00000318763.5	+	1	329	c.286G>T	c.(286-288)Gga>Tga	p.G96*		NM_001004484.1	NP_001004484.1	Q8NGV5	O13D1_HUMAN	olfactory receptor, family 13, subfamily D, member 1	96					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(4)|lung(10)|ovary(1)|prostate(2)|skin(2)	19						TTTCTTTCTTGGAAACCTCTC	0.413000													11	337					0.000219431	0.00709528	0.000219431	1	0
CACNG8	59283	broad.mit.edu	37	19	54466610	54466610	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr19:54466610G>A	ENST00000270458.2	+	1	317	c.214G>A	c.(214-216)Ggc>Agc	p.G72S		NM_031895.5	NP_114101.4	Q8WXS5	CCG8_HUMAN	calcium channel, voltage-dependent, gamma subunit 8	72					regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|endocytic vesicle membrane|postsynaptic density|postsynaptic membrane|voltage-gated calcium channel complex	voltage-gated calcium channel activity			kidney(1)|large_intestine(3)|lung(8)|urinary_tract(1)	13	all_cancers(19;0.0385)|all_epithelial(19;0.0207)|all_lung(19;0.145)|Lung NSC(19;0.168)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.162)		CGGGGGCGGCGGCGCCTCGGA	0.726000													3	7					0	0	0.00024832	0	0
DHRS4L1	728635	broad.mit.edu	37	14	24511906	24511906	+	RNA	SNP	C	C	T			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr14:24511906C>T	ENST00000558293.1	+	0	437					NR_102693.1				dehydrogenase/reductase (SDR family) member 4 like 1																		GGCTATGAAGCTTCATGGAGT	0.448000													18	98					0	0	9.7654e-05	0	0
XRN2	22803	broad.mit.edu	37	20	21336733	21336733	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr20:21336733T>C	ENST00000377191.3	+	22	2131	c.2036T>C	c.(2035-2037)cTt>cCt	p.L679P	XRN2_ENST00000430571.2_Missense_Mutation_p.L603P|XRN2_ENST00000539513.1_Missense_Mutation_p.L625P	NM_012255.3	NP_036387.2	Q9H0D6	XRN2_HUMAN	5'-3' exoribonuclease 2	679					cell growth|DNA catabolic process, exonucleolytic|mRNA processing|regulation of transcription, DNA-dependent|RNA catabolic process|spermatogenesis|transcription termination, DNA-dependent	nucleolus	5'-3' exoribonuclease activity|nucleic acid binding|protein binding|zinc ion binding			endometrium(5)|kidney(6)|large_intestine(10)|lung(12)|ovary(1)|skin(5)	39						AGAAACAGCCTTGGAGGTGAT	0.403000													7	55					0	0	0.000157383	0	0
HMBOX1	79618	broad.mit.edu	37	8	28906499	28906499	+	Silent	SNP	A	A	T			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr8:28906499A>T	ENST00000397358.3	+	10	1763	c.1059A>T	c.(1057-1059)atA>atT	p.I353I	HMBOX1_ENST00000444075.1_Silent_p.I352I|HMBOX1_ENST00000519047.1_Silent_p.I352I|HMBOX1_ENST00000523613.1_Silent_p.I353I|HMBOX1_ENST00000355231.5_Silent_p.I352I|HMBOX1_ENST00000558662.1_Silent_p.I352I|HMBOX1_ENST00000517386.1_3'UTR|HMBOX1_ENST00000287701.10_Silent_p.I353I|HMBOX1_ENST00000524238.1_Silent_p.I352I	NM_024567.3	NP_078843.2	Q6NT76	HMBX1_HUMAN	homeobox containing 1	353					negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent	cytoplasm|nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			cervix(1)|endometrium(5)|kidney(1)|large_intestine(1)|lung(2)|ovary(1)	11		Ovarian(32;0.0192)		KIRC - Kidney renal clear cell carcinoma(542;0.135)|Kidney(114;0.161)		GTCATGGGATAGATGTGCAGA	0.473000													13	127					0	0	7.07596e-05	0	0
POSTN	10631	broad.mit.edu	37	13	38138655	38138655	+	Splice_Site	SNP	C	C	T			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr13:38138655C>T	ENST00000379747.4	-	22	2591		c.e22+1		POSTN_ENST00000379743.4_Splice_Site|POSTN_ENST00000379742.4_Splice_Site|POSTN_ENST00000379749.4_Splice_Site|POSTN_ENST00000541179.1_Splice_Site|POSTN_ENST00000541481.1_Splice_Site	NM_006475.2	NP_006466.2	Q15063	POSTN_HUMAN	periostin, osteoblast specific factor						cell adhesion|skeletal system development	proteinaceous extracellular matrix	heparin binding			cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(16)|lung(22)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	59		Lung NSC(96;2.09e-05)|Prostate(109;0.0513)|Breast(139;0.0538)|Lung SC(185;0.0743)		all cancers(112;2.48e-08)|Epithelial(112;2.78e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000853)|BRCA - Breast invasive adenocarcinoma(63;0.013)|GBM - Glioblastoma multiforme(144;0.0154)		AATACACTTACCTTGAACTTT	0.323000													28	96					0	0	0.000339439	0	0
PTPRZ1	5803	broad.mit.edu	37	7	121701229	121701229	+	Silent	SNP	A	A	C			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr7:121701229A>C	ENST00000393386.2	+	30	7314	c.6903A>C	c.(6901-6903)gcA>gcC	p.A2301A	PTPRZ1_ENST00000449182.1_Silent_p.A1434A	NM_001206838.1|NM_002851.2	NP_001193767.1|NP_002842.2	P23471	PTPRZ_HUMAN	protein tyrosine phosphatase, receptor-type, Z polypeptide 1	2301					central nervous system development	integral to plasma membrane	protein binding|protein tyrosine/threonine phosphatase activity|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(3)|central_nervous_system(4)|cervix(1)|endometrium(4)|kidney(12)|large_intestine(17)|liver(1)|lung(42)|ovary(4)|prostate(5)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(2)	106						ATGGTGCAGCATTGCCTGATG	0.448000													24	38					0	0	7.16444e-05	0	0
PCDH10	57575	broad.mit.edu	37	4	134072296	134072296	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr4:134072296G>T	ENST00000264360.4	+	1	1827	c.1001G>T	c.(1000-1002)gGc>gTc	p.G334V		NM_032961.1	NP_116586.1	Q9P2E7	PCD10_HUMAN	protocadherin 10	334	Cadherin 3.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(2)|breast(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(30)|liver(1)|lung(72)|ovary(2)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(6)|urinary_tract(2)	136				LUSC - Lung squamous cell carcinoma(193;0.227)		AAGGACCTGGGCCCCAACGCC	0.597000													11	40					3.86212e-05	0.00133451	3.86212e-05	1	0
ATG2B	55102	broad.mit.edu	37	14	96772063	96772063	+	Silent	SNP	G	G	C			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr14:96772063G>C	ENST00000359933.4	-	31	5489	c.4596C>G	c.(4594-4596)acC>acG	p.T1532T	ATG2B_ENST00000261834.5_5'UTR	NM_018036.5	NP_060506.5	Q96BY7	ATG2B_HUMAN	autophagy related 2B	1532										breast(3)|cervix(2)|endometrium(7)|kidney(4)|large_intestine(11)|liver(1)|lung(26)|ovary(1)|prostate(1)|skin(1)|urinary_tract(7)	64		all_cancers(154;0.0462)|all_epithelial(191;0.123)|Melanoma(154;0.155)		Epithelial(152;0.21)|COAD - Colon adenocarcinoma(157;0.244)		TGCTCGTATCGGTCTTATTAA	0.403000													3	48					0	0	6.4e-05	0	0
SCRN1	9805	broad.mit.edu	37	7	29983623	29983623	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr7:29983623C>G	ENST00000426154.1	-	4	690	c.514G>C	c.(514-516)Ggg>Cgg	p.G172R	SCRN1_ENST00000416113.2_Missense_Mutation_p.G63R|SCRN1_ENST00000242059.5_Missense_Mutation_p.G172R|SCRN1_ENST00000409497.1_Missense_Mutation_p.G172R	NM_001145513.1	NP_001138985.1	Q12765	SCRN1_HUMAN	secernin 1	172					exocytosis|proteolysis	cytoplasm|nuclear membrane	dipeptidase activity			breast(2)|endometrium(3)|kidney(1)|large_intestine(1)|lung(12)|ovary(2)|prostate(2)|skin(2)	25						CAGTACTTCCCTATGGTCTCG	0.527000													7	45					0	0	8.12818e-05	0	0
ALG10	84920	broad.mit.edu	37	12	34175620	34175620	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr12:34175620G>T	ENST00000266483.2	+	1	405	c.86G>T	c.(85-87)cGg>cTg	p.R29L	ALG10_ENST00000538927.1_Missense_Mutation_p.R29L|RP11-847H18.2_ENST00000501954.2_RNA	NM_032834.3	NP_116223.3	Q5BKT4	AG10A_HUMAN	ALG10, alpha-1,2-glucosyltransferase	29					dolichol-linked oligosaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane|integral to membrane	dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity			NS(1)|breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(3)|lung(13)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	26	Lung NSC(5;3.82e-05)|Acute lymphoblastic leukemia(23;0.0142)|all_hematologic(23;0.0429)	Lung NSC(34;0.204)|all_lung(34;0.235)				GCCTTCAGCCGGGCGTTGCGA	0.597000													12	122					0.000151284	0.00500659	0.000151284	1	0
CCBL2	56267	broad.mit.edu	37	1	89426943	89426943	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr1:89426943T>C	ENST00000260508.4	-	8	1031	c.694A>G	c.(694-696)Att>Gtt	p.I232V	CCBL2_ENST00000446900.2_5'UTR|CCBL2_ENST00000370485.2_3'UTR|CCBL2_ENST00000370491.3_Missense_Mutation_p.I198V	NM_001008661.2	NP_001008661.1	Q6YP21	KAT3_HUMAN	cysteine conjugate-beta lyase 2	232					biosynthetic process|kynurenine metabolic process|tryptophan catabolic process		cysteine-S-conjugate beta-lyase activity|kynurenine-glyoxylate transaminase activity|kynurenine-oxoglutarate transaminase activity|pyridoxal phosphate binding			endometrium(3)|kidney(4)|large_intestine(2)|lung(4)|ovary(2)|skin(2)|soft_tissue(1)	18		Lung NSC(277;0.123)		all cancers(265;0.0117)|Epithelial(280;0.0341)	L-Glutamic Acid(DB00142)|Pyridoxal Phosphate(DB00114)	AGGTCAGCAATTACTTGCAGT	0.363000													17	85					0	0	3.45872e-05	0	0
VPS13B	157680	broad.mit.edu	37	8	100493917	100493917	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr8:100493917C>A	ENST00000395996.1	+	25	3868	c.3757C>A	c.(3757-3759)Cca>Aca	p.P1253T	VPS13B_ENST00000357162.2_Missense_Mutation_p.P1253T|VPS13B_ENST00000358544.2_Missense_Mutation_p.P1253T			Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13 homolog B (yeast)	1253					protein transport					NS(1)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(37)|lung(78)|ovary(8)|pancreas(3)|prostate(5)|skin(9)|upper_aerodigestive_tract(4)|urinary_tract(9)	193	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			TCCAACCTCTCCAGAGACCAT	0.483000													7	132					1.06961e-07	4.01048e-06	0.000157383	1	0
CCDC107	203260	broad.mit.edu	37	9	35660929	35660929	+	Silent	SNP	C	C	G			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr9:35660929C>G	ENST00000426546.2	+	5	663	c.597C>G	c.(595-597)ccC>ccG	p.P199P	ARHGEF39_ENST00000378387.3_3'UTR|ARHGEF39_ENST00000378395.2_3'UTR|CCDC107_ENST00000327351.2_Intron|CCDC107_ENST00000421582.2_3'UTR|CCDC107_ENST00000378406.1_3'UTR|CCDC107_ENST00000378407.3_3'UTR|CCDC107_ENST00000378409.3_Intron|ARHGEF39_ENST00000343259.3_3'UTR	NM_001195200.1|NM_001195201.1|NM_001195217.1|NM_174923.2	NP_001182129.1|NP_001182130.1|NP_001182146.1|NP_777583.2	Q8WV48	CC107_HUMAN	coiled-coil domain containing 107	199						integral to membrane				endometrium(1)|lung(3)|skin(1)	5	all_epithelial(49;0.217)		Lung(28;0.00276)|LUSC - Lung squamous cell carcinoma(32;0.00418)|STAD - Stomach adenocarcinoma(86;0.194)			TGATCTCTCCCCACACAGAGG	0.547000													4	120					0	0	3.59834e-05	0	0
GALNT8	26290	broad.mit.edu	37	12	4835909	4835909	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr12:4835909G>C	ENST00000252318.2	+	2	760	c.423G>C	c.(421-423)caG>caC	p.Q141H	RP11-234B24.6_ENST00000544741.2_3'UTR	NM_017417.1	NP_059113.1	Q9NY28	GALT8_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 8 (GalNAc-T8)	141						Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(13)|ovary(2)|pancreas(1)|prostate(4)|skin(2)|urinary_tract(1)	35						AGGCGGCCCAGGACCTCTTCC	0.547000													4	21					0	0	0.00024832	0	0
SYNE2	23224	broad.mit.edu	37	14	64443439	64443439	+	Missense_Mutation	SNP	A	A	T			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr14:64443439A>T	ENST00000358025.3	+	12	1517	c.1287A>T	c.(1285-1287)ttA>ttT	p.L429F	SYNE2_ENST00000554584.1_Missense_Mutation_p.L429F|SYNE2_ENST00000357395.3_5'UTR|SYNE2_ENST00000344113.4_Missense_Mutation_p.L429F	NM_182914.2	NP_878918.2	Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	429					centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			NS(5)|breast(17)|central_nervous_system(3)|cervix(8)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(21)|large_intestine(34)|lung(75)|ovary(10)|pancreas(2)|prostate(8)|skin(8)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(4)	224				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		AAATGACTTTATTCAAGGTTG	0.383000													14	142					0	0	0.000132079	0	0
PCDHB11	56125	broad.mit.edu	37	5	140579439	140579439	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr5:140579439G>A	ENST00000354757.3	+	1	92	c.92G>A	c.(91-93)tGg>tAg	p.W31*	PCDHB11_ENST00000536699.1_Intron	NM_018931.2	NP_061754.1	Q9Y5F2	PCDBB_HUMAN		31					calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			NS(2)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(23)|ovary(4)|prostate(3)|skin(6)|upper_aerodigestive_tract(5)|urinary_tract(1)	63			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TCTGAAACCTGGAGCTTTTCT	0.527000													7	29					0	0	8.12818e-05	0	0
OR1N2	138882	broad.mit.edu	37	9	125315761	125315761	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr9:125315761C>G	ENST00000373688.2	+	1	371	c.313C>G	c.(313-315)Cag>Gag	p.Q105E		NM_001004457.1	NP_001004457.1	Q8NGR9	OR1N2_HUMAN	olfactory receptor, family 1, subfamily N, member 2	105					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|large_intestine(6)|lung(10)|ovary(2)|skin(3)|stomach(3)	26						CATTCATACCCAGAGTCAGAT	0.478000													4	133					0	0	1.23904e-05	0	0
SMCO1	255798	broad.mit.edu	37	3	196235135	196235135	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr3:196235135G>C	ENST00000397537.2	-	3	424	c.268C>G	c.(268-270)Cgt>Ggt	p.R90G		NM_001077657.1	NP_001071125.1			single-pass membrane protein with coiled-coil domains 1																		TCAAGCACACGAGTATGCAAG	0.423000													6	200					0	0	8.12818e-05	0	0
APLP2	334	broad.mit.edu	37	11	129996669	129996669	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr11:129996669C>A	ENST00000263574.5	+	8	1237	c.1165C>A	c.(1165-1167)Cgc>Agc	p.R389S	APLP2_ENST00000278756.7_Missense_Mutation_p.R399S|APLP2_ENST00000539648.1_Missense_Mutation_p.R177S|APLP2_ENST00000345598.5_Missense_Mutation_p.R160S|APLP2_ENST00000528499.1_Missense_Mutation_p.R333S|APLP2_ENST00000543137.1_Missense_Mutation_p.R296S|APLP2_ENST00000338167.5_Missense_Mutation_p.R389S	NM_001642.2	NP_001633.1	Q06481	APLP2_HUMAN	amyloid beta (A4) precursor-like protein 2	389					G-protein coupled receptor protein signaling pathway	integral to membrane|nucleus|plasma membrane	DNA binding|identical protein binding|serine-type endopeptidase inhibitor activity			NS(1)|breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(6)|ovary(4)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	31	all_hematologic(175;0.0429)	Breast(109;0.00586)|Lung NSC(97;0.00785)|all_lung(97;0.0154)|Medulloblastoma(222;0.0523)|all_neural(223;0.186)		OV - Ovarian serous cystadenocarcinoma(99;0.0197)|Lung(977;0.24)		TGAGCATGCTCGCTTCCAGAA	0.468000													7	104					0.000157383	0.00511242	0.000157383	1	0
DDX19B	11269	broad.mit.edu	37	16	70333201	70333201	+	Translation_Start_Site	SNP	A	A	G			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr16:70333201A>G	ENST00000288071.6	+	1	246	c.1A>G	c.(1-3)Atg>Gtg	p.M1V	RP11-529K1.3_ENST00000567706.1_Start_Codon_SNP_p.M1V|DDX19B_ENST00000570055.1_Intron|DDX19B_ENST00000568625.1_Intron|DDX19B_ENST00000393657.2_5'UTR|DDX19B_ENST00000563392.1_Intron|DDX19B_ENST00000355992.3_Start_Codon_SNP_p.M1V|DDX19B_ENST00000563206.1_Intron|DDX19B_ENST00000451014.3_Intron	NM_007242.5	NP_009173.1	Q9UMR2	DD19B_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 19B	1					mRNA export from nucleus|protein transport|transmembrane transport	cytoplasm|nuclear membrane|nuclear pore	ATP binding|ATP-dependent helicase activity|protein binding|RNA binding			cervix(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(1)|prostate(1)	9		Ovarian(137;0.0694)				GCCTGGGACCATGGCCACTGA	0.667000													3	4					0	0	6.4e-05	0	0
TDRKH	11022	broad.mit.edu	37	1	151748310	151748310	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr1:151748310C>G	ENST00000368822.1	-	9	1901	c.1268G>C	c.(1267-1269)cGg>cCg	p.R423P	TDRKH_ENST00000368827.6_Missense_Mutation_p.R423P|TDRKH_ENST00000368824.3_Missense_Mutation_p.R423P|TDRKH_ENST00000368823.1_Missense_Mutation_p.R419P|TDRKH_ENST00000368825.3_Missense_Mutation_p.R378P|TDRKH_ENST00000458431.2_Missense_Mutation_p.R423P|TDRKH_ENST00000440583.2_Missense_Mutation_p.R199P			Q9Y2W6	TDRKH_HUMAN	tudor and KH domain containing	423							RNA binding			breast(5)|cervix(2)|endometrium(1)|kidney(1)|large_intestine(4)|lung(7)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	26	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.14)		LUSC - Lung squamous cell carcinoma(543;0.181)			GGGAGCAATCCGTGCCAGACT	0.403000													4	165					0	0	8.12818e-05	0	0
LCE1C	353133	broad.mit.edu	37	1	152777761	152777761	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr1:152777761C>A	ENST00000368768.1	-	2	244	c.194G>T	c.(193-195)gGg>gTg	p.G65V	LCE1C_ENST00000607093.1_Missense_Mutation_p.G65V	NM_178351.3	NP_848128.1	Q5T751	LCE1C_HUMAN	late cornified envelope 1C	65	Gly-rich.				keratinization			p.G65V(1)		NS(1)|lung(4)|prostate(1)|skin(2)|urinary_tract(1)	9	Lung NSC(65;9.06e-30)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.171)			GCAGCATCCCCCAGAGCTGGA	0.662000													7	42					2.0095e-06	7.19033e-05	8.12818e-05	1	0
CCDC14	64770	broad.mit.edu	37	3	123665745	123665745	+	Missense_Mutation	SNP	T	T	A			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr3:123665745T>A	ENST00000485727.1	-	4	5242	c.650A>T	c.(649-651)gAt>gTt	p.D217V	CCDC14_ENST00000433542.2_Missense_Mutation_p.D376V|CCDC14_ENST00000488653.2_Missense_Mutation_p.D417V|CCDC14_ENST00000483247.1_Intron|CCDC14_ENST00000489746.1_Missense_Mutation_p.D217V|CCDC14_ENST00000310351.4_Missense_Mutation_p.D257V			Q49A88	CCD14_HUMAN	coiled-coil domain containing 14	417						centrosome				NS(1)|breast(2)|endometrium(2)|kidney(1)|large_intestine(5)|lung(10)	21		Lung NSC(201;0.0371)|Prostate(884;0.0405)|Myeloproliferative disorder(1037;0.205)		Lung(219;0.00942)|GBM - Glioblastoma multiforme(114;0.159)		CTTCTGTACATCCTTCACTGT	0.383000													29	157					0	0	0.000227799	0	0
C17orf66	256957	broad.mit.edu	37	17	34185928	34185928	+	Silent	SNP	C	C	T			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr17:34185928C>T	ENST00000311880.2	-	9	1051	c.903G>A	c.(901-903)caG>caA	p.Q301Q	C17orf66_ENST00000592980.1_Silent_p.Q261Q	NM_152781.2	NP_689994.2	A2RTY3	CQ066_HUMAN	chromosome 17 open reading frame 66	301							binding			breast(3)|central_nervous_system(1)|cervix(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(6)|lung(11)|skin(2)|stomach(4)	38		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0184)		GGCACAGGCACTGCAACAAGA	0.567000													9	55					0	0	3.86212e-05	0	0
ADSS	159	broad.mit.edu	37	1	244574694	244574694	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr1:244574694G>T	ENST00000366535.3	-	12	1529	c.1213C>A	c.(1213-1215)Ctc>Atc	p.L405I		NM_001126.3	NP_001117.2	P30520	PURA2_HUMAN	adenylosuccinate synthase	405					AMP biosynthetic process|immune system process|purine base metabolic process	cytosol|plasma membrane	adenylosuccinate synthase activity|GTP binding|magnesium ion binding|phosphate binding			endometrium(2)|kidney(1)|large_intestine(3)|lung(1)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	12	all_cancers(71;2.17e-05)|all_epithelial(71;0.00015)|all_neural(11;0.0269)|Breast(184;0.0654)|Glioma(6;0.0724)|Ovarian(71;0.0761)|all_lung(81;0.0874)|Lung NSC(105;0.121)	all_cancers(173;0.0896)|all_epithelial(177;0.172)	all cancers(7;9.71e-08)|GBM - Glioblastoma multiforme(7;1.28e-05)|OV - Ovarian serous cystadenocarcinoma(106;0.0014)		L-Aspartic Acid(DB00128)	CATCCTGGGAGAGTCTTATAT	0.343000													20	133					1.28384e-07	4.76304e-06	0.000229342	1	0
ZNF660	285349	broad.mit.edu	37	3	44636533	44636533	+	Missense_Mutation	SNP	T	T	A			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr3:44636533T>A	ENST00000322734.2	+	3	1181	c.848T>A	c.(847-849)tTc>tAc	p.F283Y	RP11-944L7.4_ENST00000457331.1_RNA	NM_173658.2	NP_775929.2	Q6AZW8	ZN660_HUMAN	zinc finger protein 660	283					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(2)|lung(4)	6				KIRC - Kidney renal clear cell carcinoma(197;0.0468)|Kidney(197;0.0585)		GGGAAAACCTTCAGGCAGACT	0.413000													11	25					0	0	0.000151284	0	0
MCOLN2	255231	broad.mit.edu	37	1	85395292	85395292	+	Missense_Mutation	SNP	T	T	A			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr1:85395292T>A	ENST00000370608.3	-	13	1680	c.1613A>T	c.(1612-1614)gAg>gTg	p.E538V	MCOLN2_ENST00000284027.5_Missense_Mutation_p.E510V	NM_153259.2	NP_694991.2	Q8IZK6	MCLN2_HUMAN	mucolipin 2	538						integral to membrane	ion channel activity			NS(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(7)|ovary(3)|prostate(1)|upper_aerodigestive_tract(2)	18				all cancers(265;0.0111)|Epithelial(280;0.0263)|OV - Ovarian serous cystadenocarcinoma(397;0.217)		TTTCTGATACTCTTCTTTGCT	0.438000													5	20					0	0	1.23904e-05	0	0
SAGE1	55511	broad.mit.edu	37	X	134994090	134994090	+	Silent	SNP	A	A	G			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chrX:134994090A>G	ENST00000535938.1	+	18	2666	c.2499A>G	c.(2497-2499)aaA>aaG	p.K833K	SAGE1_ENST00000324447.3_Silent_p.K833K|SAGE1_ENST00000537770.1_Silent_p.K457K|SAGE1_ENST00000370709.3_Silent_p.K833K	NM_018666.2	NP_061136.2	Q9NXZ1	SAGE1_HUMAN	sarcoma antigen 1	833										breast(5)|endometrium(5)|large_intestine(10)|lung(23)|ovary(3)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	55	Acute lymphoblastic leukemia(192;0.000127)					AATTAATGAAAGAAGTTCGAA	0.348000													14	61					0	0	3.45872e-05	0	0
AHNAK	79026	broad.mit.edu	37	11	62297926	62297926	+	Silent	SNP	G	G	T			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr11:62297926G>T	ENST00000378024.4	-	5	4237	c.3963C>A	c.(3961-3963)ccC>ccA	p.P1321P	AHNAK_ENST00000257247.7_Intron|AHNAK_ENST00000530124.1_Intron	NM_001620.1	NP_001611.1	Q09666	AHNK_HUMAN	AHNAK nucleoprotein	1321					nervous system development	nucleus	protein binding			NS(3)|autonomic_ganglia(1)|breast(10)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(33)|large_intestine(40)|liver(1)|lung(108)|ovary(13)|pancreas(4)|prostate(5)|skin(16)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(6)	268		Melanoma(852;0.155)				TGGAGATCTTGGGGGCCTTGA	0.517000													33	80					1.03484e-13	4.12122e-12	0.000191422	1	0
FAM179A	165186	broad.mit.edu	37	2	29240047	29240047	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr2:29240047C>G	ENST00000379558.4	+	9	1423	c.1072C>G	c.(1072-1074)Cgg>Ggg	p.R358G	FAM179A_ENST00000465300.1_Intron|FAM179A_ENST00000403861.2_Missense_Mutation_p.R358G	NM_199280.2	NP_954974.2	Q6ZUX3	F179A_HUMAN	family with sequence similarity 179, member A	358							binding			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(5)|lung(9)|ovary(3)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	26						CAAGTCTGCCCGGGAGAAGAT	0.517000													4	93					0	0	3.59834e-05	0	0
DGKD	8527	broad.mit.edu	37	2	234296984	234296984	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr2:234296984C>T	ENST00000264057.2	+	2	250	c.238C>T	c.(238-240)Cga>Tga	p.R80*	DGKD_ENST00000409813.3_Nonsense_Mutation_p.R36*|DGKD_ENST00000489613.1_3'UTR|AC019221.4_ENST00000442524.1_RNA	NM_152879.2	NP_690618.2	Q16760	DGKD_HUMAN	diacylglycerol kinase, delta 130kDa	80	PH.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|cell growth|diacylglycerol metabolic process|endocytosis|epidermal growth factor receptor signaling pathway|multicellular organismal development|platelet activation|protein homooligomerization|protein transport|response to organic substance|second-messenger-mediated signaling	cytoplasm|cytoplasmic membrane-bounded vesicle|plasma membrane	ATP binding|diacylglycerol binding|diacylglycerol kinase activity|metal ion binding|protein heterodimerization activity|protein homodimerization activity			central_nervous_system(2)|endometrium(4)|kidney(1)|large_intestine(13)|lung(15)|ovary(1)|pancreas(1)|skin(1)	38		Breast(86;0.0013)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0179)|Acute lymphoblastic leukemia(138;0.0326)|Lung NSC(271;0.0538)		Epithelial(121;1.31e-16)|BRCA - Breast invasive adenocarcinoma(100;0.000416)|Lung(119;0.00285)|LUSC - Lung squamous cell carcinoma(224;0.00655)	Phosphatidylserine(DB00144)	GCTTCGAGGGCGAACGCTTTA	0.507000													25	59					0	0	0.000117367	0	0
SNHG23	100507242	broad.mit.edu	37	14	101421764	101421764	+	RNA	SNP	C	C	T			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr14:101421764C>T	ENST00000556637.1	+	0	399				SNORD114-5_ENST00000362928.1_RNA																							GTGTCTAGAACTCTGAGGTCC	0.418000													10	34					0	0	6.40141e-05	0	0
INTS12	57117	broad.mit.edu	37	4	106621142	106621142	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr4:106621142C>A	ENST00000451321.2	-	2	500	c.21G>T	c.(19-21)ttG>ttT	p.L7F	INTS12_ENST00000340139.5_Missense_Mutation_p.L7F|INTS12_ENST00000394735.1_Missense_Mutation_p.L7F	NM_001142471.1	NP_001135943.1	Q96CB8	INT12_HUMAN	integrator complex subunit 12	7					snRNA processing	integrator complex	protein binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(6)|prostate(1)|skin(1)|urinary_tract(1)	14				OV - Ovarian serous cystadenocarcinoma(123;5.12e-07)		GATCAAGTTCCAAGTTCACAG	0.358000													10	168					0.000151284	0.00500659	0.000151284	1	0
ABCA12	26154	broad.mit.edu	37	2	215976352	215976352	+	Missense_Mutation	SNP	C	C	A	rs113648834		TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr2:215976352C>A	ENST00000272895.7	-	2	350	c.131G>T	c.(130-132)cGg>cTg	p.R44L	ABCA12_ENST00000412081.1_Missense_Mutation_p.R44L	NM_173076.2	NP_775099.2	Q86UK0	ABCAC_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 12	44					cellular homeostasis|lipid transport	integral to membrane	ATP binding|ATPase activity			NS(3)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(45)|lung(44)|ovary(8)|pancreas(2)|prostate(4)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	139		Renal(323;0.127)		Epithelial(149;1.01e-05)|all cancers(144;0.00112)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.011)		AAATTTGGTCCGAGTAATAGC	0.299000													6	103					0.000157383	0.00511242	0.000157383	1	0
MROH2B	133558	broad.mit.edu	37	5	40999824	40999824	+	Missense_Mutation	SNP	T	T	G			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr5:40999824T>G	ENST00000399564.4	-	40	4990	c.4540A>C	c.(4540-4542)Acc>Ccc	p.T1514P	MROH2B_ENST00000506092.2_Missense_Mutation_p.T1069P	NM_173489.4	NP_775760.3			maestro heat-like repeat family member 2B																		CAGGTGCTGGTGAAGAAGGTG	0.468000													3	63					0	0	1.23904e-05	0	0
RNF180	285671	broad.mit.edu	37	5	63509383	63509383	+	Splice_Site	SNP	A	A	T			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr5:63509383A>T	ENST00000389100.4	+	4	303		c.e4-1		RNF180_ENST00000381081.2_Intron|RNF180_ENST00000296615.6_Splice_Site	NM_001113561.1	NP_001107033.1	Q86T96	RN180_HUMAN	ring finger protein 180							integral to membrane|nuclear envelope	zinc ion binding			breast(1)|kidney(1)|large_intestine(4)|lung(9)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	20		Lung NSC(810;3.55e-06)|Prostate(74;0.0352)|Ovarian(174;0.0545)|Breast(144;0.0848)|Colorectal(97;0.234)		Lung(70;0.114)		TATTACCTGTAGGCCCAGTGG	0.398000													28	107					0	0	7.24521e-05	0	0
IQUB	154865	broad.mit.edu	37	7	123097503	123097503	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr7:123097503G>A	ENST00000466202.1	-	12	2701	c.2125C>T	c.(2125-2127)Ccc>Tcc	p.P709S	IQUB_ENST00000324698.6_Missense_Mutation_p.P709S|RP11-332K15.1_ENST00000419832.1_RNA			Q8NA54	IQUB_HUMAN	IQ motif and ubiquitin domain containing	709										breast(1)|endometrium(5)|kidney(3)|large_intestine(9)|lung(18)|ovary(3)|prostate(2)|stomach(3)|upper_aerodigestive_tract(1)	45						CAGTTCCAGGGGGACCACTCC	0.453000													18	96					0	0	0.000229342	0	0
HDAC9	9734	broad.mit.edu	37	7	18687544	18687544	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr7:18687544C>T	ENST00000406451.3	+	10	1313	c.1163C>T	c.(1162-1164)cCc>cTc	p.P388L	HDAC9_ENST00000441542.2_Missense_Mutation_p.P391L|HDAC9_ENST00000524023.1_Missense_Mutation_p.P311L|HDAC9_ENST00000401921.1_Missense_Mutation_p.P347L|HDAC9_ENST00000405010.3_Missense_Mutation_p.P388L|HDAC9_ENST00000432645.2_Missense_Mutation_p.P388L|HDAC9_ENST00000428307.2_Missense_Mutation_p.P344L|HDAC9_ENST00000417496.2_Missense_Mutation_p.P386L|HDAC9_ENST00000406072.1_Missense_Mutation_p.P375L|HDAC9_ENST00000456174.2_Missense_Mutation_p.P360L	NM_178423.1|NM_178425.2	NP_848510.1|NP_848512.1	Q9UKV0	HDAC9_HUMAN	histone deacetylase 9	388					B cell differentiation|cellular response to insulin stimulus|heart development|histone H3 deacetylation|histone H4 deacetylation|inflammatory response|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|peptidyl-lysine deacetylation|positive regulation of cell migration involved in sprouting angiogenesis|regulation of skeletal muscle fiber development|transcription, DNA-dependent	cytoplasm|histone deacetylase complex|histone methyltransferase complex|transcription factor complex	histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|protein binding|protein kinase C binding|repressing transcription factor binding|transcription corepressor activity			breast(3)|central_nervous_system(4)|cervix(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(18)|liver(2)|lung(37)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	82	all_lung(11;0.187)				Valproic Acid(DB00313)	GGAAAGCCACCCAACAGCAGC	0.502000													4	8					0	0	0.00024832	0	0
TTC3	7267	broad.mit.edu	37	21	38516833	38516833	+	Missense_Mutation	SNP	A	A	C			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr21:38516833A>C	ENST00000399017.2	+	21	4528	c.1781A>C	c.(1780-1782)gAa>gCa	p.E594A	TTC3_ENST00000355666.1_Missense_Mutation_p.E594A|TTC3_ENST00000354749.2_Missense_Mutation_p.E594A|TTC3_ENST00000479930.1_3'UTR|TTC3_ENST00000540756.1_Missense_Mutation_p.E284A	NM_003316.3	NP_003307.3	P53804	TTC3_HUMAN	tetratricopeptide repeat domain 3	594					protein K48-linked ubiquitination|ubiquitin-dependent protein catabolic process	nucleus	protein binding|ubiquitin-protein ligase activity|zinc ion binding			breast(5)|endometrium(7)|kidney(5)|large_intestine(17)|liver(1)|lung(18)|ovary(4)|prostate(2)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(5)	75		Myeloproliferative disorder(46;0.0412)				AGATTTCTAGAAGCTCTCAAT	0.373000													25	83					0	0	7.16444e-05	0	0
DPP10	57628	broad.mit.edu	37	2	116510785	116510785	+	Missense_Mutation	SNP	A	A	T			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr2:116510785A>T	ENST00000410059.1	+	11	1466	c.986A>T	c.(985-987)aAt>aTt	p.N329I	DPP10_ENST00000310323.8_Missense_Mutation_p.N322I|DPP10_ENST00000393147.2_Missense_Mutation_p.N333I|DPP10_ENST00000409163.1_Missense_Mutation_p.N279I	NM_001178037.1|NM_020868.3	NP_001171508.1|NP_065919.2	Q8N608	DPP10_HUMAN	dipeptidyl-peptidase 10 (non-functional)	329					proteolysis	integral to membrane|membrane fraction	serine-type peptidase activity			breast(4)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(24)|liver(2)|lung(48)|ovary(6)|prostate(1)|skin(5)|soft_tissue(1)	101						TGGGTAAGCAATACCAAGACT	0.363000													10	41					0	0	0.00010058	0	0
SHC2	25759	broad.mit.edu	37	19	436383	436383	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr19:436383T>C	ENST00000264554.6	-	6	822	c.823A>G	c.(823-825)Aga>Gga	p.R275G		NM_012435.2	NP_036567.2	P98077	SHC2_HUMAN	SHC (Src homology 2 domain containing) transforming protein 2	275	PID.				insulin receptor signaling pathway|nerve growth factor receptor signaling pathway|Ras protein signal transduction	cytosol				endometrium(2)|kidney(1)|large_intestine(2)|lung(13)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	21		all_cancers(10;1.13e-36)|all_epithelial(18;1.46e-23)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.1e-06)|all_lung(49;1.55e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GCCTCACCTCTCTGGTTGATG	0.716000													9	16					0	0	3.86212e-05	0	0
WDR26	80232	broad.mit.edu	37	1	224607315	224607315	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr1:224607315T>C	ENST00000414423.2	-	5	960	c.767A>G	c.(766-768)tAt>tGt	p.Y256C	WDR26_ENST00000295024.6_Missense_Mutation_p.Y109C|WDR26_ENST00000366852.2_3'UTR	NM_001115113.2|NM_025160.6	NP_001108585.2|NP_079436.4	Q9H7D7	WDR26_HUMAN	WD repeat domain 26	256						cytoplasm|nucleus				biliary_tract(1)|breast(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(6)	18				GBM - Glioblastoma multiforme(131;0.0104)		ACACATCAGATACCTAAAAAT	0.378000													37	33					0	0	0.000270559	0	0
PSG8	440533	broad.mit.edu	37	19	43262160	43262160	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr19:43262160G>A	ENST00000404209.4	-	3	799	c.703C>T	c.(703-705)Ctc>Ttc	p.L235F	PSG8_ENST00000600709.1_5'UTR|PSG8_ENST00000306511.4_Missense_Mutation_p.L235F|PSG8_ENST00000406636.3_Missense_Mutation_p.L113F|PSG8_ENST00000401467.2_Intron	NM_001130167.1	NP_001123639.1	Q9UQ74	PSG8_HUMAN	pregnancy specific beta-1-glycoprotein 8	235						extracellular region				breast(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(9)|lung(19)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	40		Prostate(69;0.00899)				TCACGGAGGAGATTCAGGGTG	0.527000													24	117					0	0	0.000227799	0	0
STK32A	202374	broad.mit.edu	37	5	146752790	146752790	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr5:146752790C>A	ENST00000397936.3	+	10	1169	c.836C>A	c.(835-837)cCg>cAg	p.P279Q	STK32A_ENST00000398523.3_Missense_Mutation_p.P279Q	NM_001112724.1	NP_001106195.1	Q8WU08	ST32A_HUMAN	serine/threonine kinase 32A	279	Protein kinase.						ATP binding|metal ion binding|protein serine/threonine kinase activity	p.P279Q(1)		breast(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(7)|prostate(1)|skin(1)	13			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CAGAACTTCCCGTATATGAAT	0.398000													7	90					0.000157383	0.00511242	0.000157383	1	0
CXXC5	51523	broad.mit.edu	37	5	139060331	139060331	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr5:139060331C>T	ENST00000302517.3	+	2	937	c.223C>T	c.(223-225)Cgc>Tgc	p.R75C	CXXC5_ENST00000511048.1_Missense_Mutation_p.R75C	NM_016463.7	NP_057547.5	Q7LFL8	CXXC5_HUMAN	CXXC finger protein 5	75					positive regulation of I-kappaB kinase/NF-kappaB cascade	cytoplasm|nucleus	DNA binding|signal transducer activity|zinc ion binding	p.R75C(1)		central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(7)|upper_aerodigestive_tract(1)	12			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GAGCCTGCGCCGCTCCCGCCC	0.647000													7	24					0	0	0.000157383	0	0
PCDHA7	56141	broad.mit.edu	37	5	140216146	140216146	+	Silent	SNP	G	G	A			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr5:140216146G>A	ENST00000525929.1	+	1	2178	c.2178G>A	c.(2176-2178)ccG>ccA	p.P726P	PCDHA7_ENST00000378125.3_Silent_p.P726P|PCDHA6_ENST00000527624.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA4_ENST00000512229.2_Intron	NM_018910.2	NP_061733.1														NS(2)|biliary_tract(1)|breast(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(27)|ovary(3)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	63			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCTCAGCGCCGTCCTCTGAGG	0.612000													11	16					0	0	3.86212e-05	0	0
PRB3	5544	broad.mit.edu	37	12	11420146	11420146	+	RNA	SNP	G	G	C			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr12:11420146G>C	ENST00000381842.3	-	0	947				PRB3_ENST00000538488.1_RNA|PRB3_ENST00000279573.6_RNA|PRB3_ENST00000440870.3_RNA	NM_006249.4	NP_006240.4	Q04118	PRB3_HUMAN	proline-rich protein BstNI subfamily 3							extracellular region	Gram-negative bacterial cell surface binding			breast(2)|endometrium(1)|kidney(2)|large_intestine(1)|lung(13)|ovary(1)|skin(5)	25			OV - Ovarian serous cystadenocarcinoma(49;0.201)			GGCTGTCCCTGGGGAGGTCTG	0.552000													14	30					0	0	3.45872e-05	0	0
SPEF2	79925	broad.mit.edu	37	5	35641632	35641632	+	Silent	SNP	A	A	C			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr5:35641632A>C	ENST00000440995.2	+	3	261	c.261A>C	c.(259-261)acA>acC	p.T87T	SPEF2_ENST00000282469.6_Silent_p.T87T|SPEF2_ENST00000356031.3_Silent_p.T87T|SPEF2_ENST00000509059.1_Silent_p.T87T			Q9C093	SPEF2_HUMAN	sperm flagellar 2	87	CH.				nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		ATP binding|nucleobase, nucleoside, nucleotide kinase activity|protein dimerization activity			breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(15)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	37	all_lung(31;7.56e-05)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			GCATCATCACAGAAAAGCCTG	0.438000													10	83					0	0	6.40141e-05	0	0
PCDHGB6	56100	broad.mit.edu	37	5	140788007	140788007	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr5:140788007G>C	ENST00000520790.1	+	1	238	c.238G>C	c.(238-240)Gag>Cag	p.E80Q	PCDHGB2_ENST00000522605.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA9_ENST00000573521.1_Intron|PCDHGA8_ENST00000398604.2_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGA6_ENST00000517434.1_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGB3_ENST00000576222.1_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGB4_ENST00000519479.1_Intron|PCDHGA7_ENST00000518325.1_Intron	NM_018926.2|NM_032100.1	NP_061749.1|NP_115271.1														breast(2)|central_nervous_system(2)|endometrium(9)|kidney(1)|large_intestine(10)|lung(16)|ovary(1)|prostate(3)|stomach(2)|upper_aerodigestive_tract(2)	48			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGTAGACGCGGAGAGCGGGGA	0.537000													18	34					0	0	0.000295444	0	0
PLA2G4A	5321	broad.mit.edu	37	1	186839595	186839595	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr1:186839595C>T	ENST00000367466.3	+	3	214	c.62C>T	c.(61-63)aCg>aTg	p.T21M	PLA2G4A_ENST00000442353.2_Missense_Mutation_p.T21M|PLA2G4A_ENST00000466600.1_3'UTR	NM_024420.2	NP_077734.1	P47712	PA24A_HUMAN	phospholipase A2, group IVA (cytosolic, calcium-dependent)	21	C2.|Phospholipid binding (Probable).				phospholipid catabolic process|platelet activating factor biosynthetic process|platelet activation	cytosol|endoplasmic reticulum membrane	calcium ion binding|calcium-dependent phospholipid binding|lysophospholipase activity			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(9)|lung(22)|ovary(1)|prostate(3)|skin(4)|stomach(1)	53					Flunisolide(DB00180)|Fluocinolone Acetonide(DB00591)|Fluocinonide(DB01047)|Fluorometholone(DB00324)|Flurandrenolide(DB00846)|Fluticasone Propionate(DB00588)|Medrysone(DB00253)|Quinacrine(DB01103)	CACAAGTTTACGGTAGTGGTG	0.383000													9	29					0	0	6.40141e-05	0	0
BRCA2	675	broad.mit.edu	37	13	32971100	32971100	+	Silent	SNP	C	C	A			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr13:32971100C>A	ENST00000544455.1	+	26	9794	c.9567C>A	c.(9565-9567)ccC>ccA	p.P3189P	BRCA2_ENST00000380152.3_Silent_p.P3189P	NM_000059.3	NP_000050.2	P51587	BRCA2_HUMAN	breast cancer 2, early onset	3189					cell cycle cytokinesis|centrosome duplication|double-strand break repair via homologous recombination|negative regulation of mammary gland epithelial cell proliferation|nucleotide-excision repair|positive regulation of transcription, DNA-dependent|regulation of S phase of mitotic cell cycle	BRCA2-MAGE-D1 complex|centrosome|nucleoplasm|stored secretory granule	gamma-tubulin binding|H3 histone acetyltransferase activity|H4 histone acetyltransferase activity|protease binding|single-stranded DNA binding			NS(3)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(24)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(32)|liver(1)|lung(41)|oesophagus(5)|ovary(22)|pancreas(4)|prostate(3)|salivary_gland(1)|skin(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	183		Lung SC(185;0.0262)		all cancers(112;7.13e-07)|Epithelial(112;1.59e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.000732)|BRCA - Breast invasive adenocarcinoma(63;0.0291)|GBM - Glioblastoma multiforme(144;0.0704)		CAAATGATCCCAAGTGGTCCA	0.378000			"""D, Mis, N, F, S"""		"""breast, ovarian, pancreatic"""	"""breast, ovarian, pancreatic, leukemia  (FANCB, FANCD1)"""		Homologous recombination	Pancreatic Cancer, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Prostate Cancer;Hereditary Breast-Ovarian Cancer, BRCA2 type;Fanconi Anemia type D1, bi-allelic BRCA2 mutations;Fanconi Anemia	TCGA Ovarian(8;0.087)			10	192					0.00010058	0.00336013	0.00010058	1	0
SNX19	399979	broad.mit.edu	37	11	130785040	130785040	+	Silent	SNP	C	C	G			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr11:130785040C>G	ENST00000265909.4	-	1	1364	c.795G>C	c.(793-795)gtG>gtC	p.V265V	SNX19_ENST00000539184.1_Intron|SNX19_ENST00000530356.1_Intron|SNX19_ENST00000533214.1_Silent_p.V265V|SNX19_ENST00000533318.1_Intron|SNX19_ENST00000528555.1_Intron	NM_014758.2	NP_055573.2	Q92543	SNX19_HUMAN	sorting nexin 19	265	PXA.				cell communication|protein transport	cytoplasmic vesicle membrane	phosphatidylinositol binding|protein binding			central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(8)|ovary(3)|prostate(1)|skin(6)|urinary_tract(1)	35	all_hematologic(175;0.0597)	Lung NSC(97;0.000272)|all_lung(97;0.000608)|Breast(109;0.000962)|all_neural(223;0.0298)|Medulloblastoma(222;0.0425)		OV - Ovarian serous cystadenocarcinoma(99;0.0195)|Lung(977;0.233)		AAAAGATACCCACGAGTACAA	0.552000													4	65					0	0	0.00024832	0	0
LDB2	9079	broad.mit.edu	37	4	16760797	16760797	+	Silent	SNP	A	A	G			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr4:16760797A>G	ENST00000502640.1	-	2	367	c.219T>C	c.(217-219)gaT>gaC	p.D73D	LDB2_ENST00000441778.2_Silent_p.D73D|LDB2_ENST00000515064.1_Silent_p.D73D|LDB2_ENST00000304523.5_Silent_p.D73D			O43679	LDB2_HUMAN	LIM domain binding 2	73							LIM domain binding|transcription cofactor activity			breast(1)|endometrium(4)|kidney(1)|large_intestine(3)|lung(23)|urinary_tract(1)	33						GCTTTGGTCCATCTTCCAAAC	0.418000													11	52					0	0	6.40141e-05	0	0
RRN3	54700	broad.mit.edu	37	16	15157137	15157137	+	Silent	SNP	T	T	G			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr16:15157137T>G	ENST00000198767.6	-	17	1793	c.1710A>C	c.(1708-1710)tcA>tcC	p.S570S	PDXDC1_ENST00000535621.2_Intron|RRN3_ENST00000563559.1_Silent_p.S570S|RRN3_ENST00000540462.1_Silent_p.S388S|RRN3_ENST00000429751.2_Silent_p.S540S|RRN3_ENST00000327307.7_Silent_p.S537S	NM_018427.3	NP_060897.3	Q9NYV6	RRN3_HUMAN	RRN3 RNA polymerase I transcription factor homolog (S. cerevisiae)	570	Interaction with EIF3L.|Interaction with TWISTNB.				regulation of transcription, DNA-dependent|transcription initiation from RNA polymerase I promoter	nucleolus|nucleoplasm				NS(2)|central_nervous_system(3)|endometrium(1)|kidney(1)|large_intestine(2)|lung(7)|ovary(2)|prostate(2)	20						TGAATTTCTTTGACCTGTCAA	0.373000													18	96					0	0	0.000175454	0	0
CYP4Z2P	163720	broad.mit.edu	37	1	47325287	47325287	+	RNA	SNP	T	T	C			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr1:47325287T>C	ENST00000505841.1	-	0	1204					NR_002788.2																						AATCCAAACATAGCTGCATTG	0.388000													3	41					0	0	6.4e-05	0	0
DCLRE1B	64858	broad.mit.edu	37	1	114454676	114454676	+	Missense_Mutation	SNP	A	A	G			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr1:114454676A>G	ENST00000369563.3	+	4	1908	c.1462A>G	c.(1462-1464)Aag>Gag	p.K488E	DCLRE1B_ENST00000466480.1_Intron	NM_022836.3	NP_073747.1	Q9H816	DCR1B_HUMAN	DNA cross-link repair 1B	488					cell cycle checkpoint|DNA repair|protection from non-homologous end joining at telomere|telomeric 3' overhang formation|telomeric loop formation	centrosome|chromosome, telomeric region|nucleus	5'-3' exonuclease activity|protein binding			breast(1)|endometrium(4)|kidney(2)|large_intestine(2)|liver(2)|lung(6)|stomach(1)	18	Lung SC(450;0.184)	all_cancers(81;1.46e-05)|all_epithelial(167;2.42e-05)|all_lung(203;0.000353)|Lung NSC(69;0.000518)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		CCACAGCAGCAAGGGCACCCC	0.532000								Other identified genes with known or suspected DNA repair function					11	30					0	0	3.86212e-05	0	0
TTC14	151613	broad.mit.edu	37	3	180321093	180321093	+	Silent	SNP	A	A	T			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr3:180321093A>T	ENST00000412756.2	+	3	537	c.468A>T	c.(466-468)atA>atT	p.I156I	TTC14_ENST00000296015.4_Silent_p.I156I|TTC14_ENST00000382584.4_Silent_p.I156I	NM_001042601.2	NP_001036066.1	Q96N46	TTC14_HUMAN	tetratricopeptide repeat domain 14	156	S1 motif.						RNA binding			endometrium(3)|kidney(5)|large_intestine(9)|lung(24)|ovary(2)|pancreas(1)|skin(1)	45	all_cancers(143;9.31e-15)|Ovarian(172;0.0212)		OV - Ovarian serous cystadenocarcinoma(80;5.62e-23)|GBM - Glioblastoma multiforme(14;0.000558)			TGAGAGATATAGCCCACTTAG	0.358000													16	170					0	0	5.01169e-05	0	0
PCDHGA4	56111	broad.mit.edu	37	5	140735676	140735676	+	Silent	SNP	A	A	T			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr5:140735676A>T	ENST00000571252.1	+	1	909	c.909A>T	c.(907-909)atA>atT	p.I303I	PCDHGA1_ENST00000517417.1_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGA3_ENST00000253812.6_Intron	NM_018917.2	NP_061740.1														endometrium(1)|kidney(1)|lung(3)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ATATAACAATATTGGGGGGTC	0.443000													5	18					0	0	1.23904e-05	0	0
TRMT44	152992	broad.mit.edu	37	4	8469757	8469757	+	Nonsense_Mutation	SNP	G	G	A	rs35357682	byFrequency	TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr4:8469757G>A	ENST00000389737.4	+	9	1611	c.1611G>A	c.(1609-1611)tgG>tgA	p.W537*	TRMT44_ENST00000513449.2_Nonsense_Mutation_p.W296*	NM_152544.2	NP_689757.2			tRNA methyltransferase 44 homolog (S. cerevisiae)																		CACCTGGCTGGGAGCTTTCCC	0.587000													4	16					0	0	0.00024832	0	0
NINL	22981	broad.mit.edu	37	20	25484622	25484622	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr20:25484622C>G	ENST00000278886.6	-	7	900	c.827G>C	c.(826-828)cGg>cCg	p.R276P	NINL_ENST00000422516.1_Missense_Mutation_p.R276P	NM_025176.4	NP_079452.3	Q9Y2I6	NINL_HUMAN	ninein-like	276			R -> W (in dbSNP:rs13044759).		G2/M transition of mitotic cell cycle	cytosol|microtubule|microtubule organizing center	calcium ion binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(13)|lung(25)|ovary(2)|pancreas(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	57						CGGTTTAACCCGAGTGGAAGA	0.488000													4	91					0	0	0.00024832	0	0
CHRDL1	91851	broad.mit.edu	37	X	109919483	109919483	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chrX:109919483C>A	ENST00000218054.4	-	12	1543	c.1347G>T	c.(1345-1347)gaG>gaT	p.E449D	CHRDL1_ENST00000444321.2_Missense_Mutation_p.E450D|CHRDL1_ENST00000482160.1_Missense_Mutation_p.E371D|CHRDL1_ENST00000372042.1_Missense_Mutation_p.E451D|CHRDL1_ENST00000372045.1_Missense_Mutation_p.E443D|CHRDL1_ENST00000394797.4_Missense_Mutation_p.E449D|CHRDL1_ENST00000434224.1_Missense_Mutation_p.E370D	NM_001143981.1|NM_001143982.1|NM_145234.3	NP_001137453.1|NP_001137454.1|NP_660277.2	Q9BU40	CRDL1_HUMAN	chordin-like 1	443					BMP signaling pathway|cell differentiation|nervous system development|ossification	extracellular region				endometrium(1)|large_intestine(12)|liver(1)|lung(15)|prostate(1)|skin(1)	31						TTTCAGATCTCTCCAGGTACA	0.448000													29	44					2.46105e-21	9.91312e-20	0.000339439	1	0
HDAC4	9759	broad.mit.edu	37	2	240061464	240061464	+	Silent	SNP	G	G	A			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr2:240061464G>A	ENST00000345617.3	-	9	1685	c.894C>T	c.(892-894)tcC>tcT	p.S298S	HDAC4_ENST00000553145.1_5'UTR|HDAC4_ENST00000543185.1_5'UTR|HDAC4_ENST00000541256.1_Silent_p.S267S	NM_006037.3	NP_006028.2	P56524	HDAC4_HUMAN	histone deacetylase 4	298	Interaction with MEF2A.				B cell differentiation|cardiac muscle hypertrophy in response to stress|chromatin remodeling|histone H3 deacetylation|histone H4 deacetylation|inflammatory response|negative regulation of glycolysis|negative regulation of myotube differentiation|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|nervous system development|peptidyl-lysine deacetylation|positive regulation of cell proliferation|positive regulation of protein sumoylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of protein binding|response to denervation involved in regulation of muscle adaptation|response to interleukin-1|transcription, DNA-dependent	histone deacetylase complex|transcriptional repressor complex	activating transcription factor binding|histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|potassium ion binding|repressing transcription factor binding|zinc ion binding			NS(1)|biliary_tract(1)|breast(4)|endometrium(5)|kidney(2)|large_intestine(7)|lung(27)|ovary(3)|pancreas(1)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(5)	62		all_epithelial(40;1.45e-17)|Breast(86;1.53e-05)|Renal(207;0.000355)|all_lung(227;0.0121)|Ovarian(221;0.0183)|Lung NSC(271;0.0413)|Melanoma(123;0.0749)|all_hematologic(139;0.159)		Epithelial(121;6.38e-25)|OV - Ovarian serous cystadenocarcinoma(60;2.48e-12)|Kidney(56;6.04e-08)|KIRC - Kidney renal clear cell carcinoma(57;1.18e-06)|BRCA - Breast invasive adenocarcinoma(100;3.99e-05)|Lung(119;0.00942)|LUSC - Lung squamous cell carcinoma(224;0.04)		AGCTGGGTCCGGAGCCTGGGG	0.677000													16	28					0	0	9.7654e-05	0	0
SUGP1	57794	broad.mit.edu	37	19	19416690	19416690	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr19:19416690T>C	ENST00000247001.5	-	4	853	c.506A>G	c.(505-507)gAg>gGg	p.E169G	SUGP1_ENST00000334782.5_Missense_Mutation_p.E169G|SUGP1_ENST00000585763.1_5'UTR	NM_172231.3	NP_757386.2	Q8IWZ8	SUGP1_HUMAN	SURP and G patch domain containing 1	169					nuclear mRNA splicing, via spliceosome	nucleoplasm|spliceosomal complex	RNA binding			NS(1)|breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(7)|ovary(1)|prostate(1)|stomach(2)|urinary_tract(2)	22						ATAGTCCTCCTCCTCGTCCTC	0.647000													6	31					0	0	0.000274275	0	0
DEPDC5	9681	broad.mit.edu	37	22	32200153	32200153	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr22:32200153G>T	ENST00000400246.1	+	16	1229	c.1087G>T	c.(1087-1089)Ggt>Tgt	p.G363C	DEPDC5_ENST00000535622.1_Missense_Mutation_p.G363C|DEPDC5_ENST00000400249.2_Missense_Mutation_p.G363C|DEPDC5_ENST00000382111.2_Missense_Mutation_p.G363C|DEPDC5_ENST00000382105.2_Missense_Mutation_p.G363C|DEPDC5_ENST00000382112.3_Missense_Mutation_p.G363C|DEPDC5_ENST00000266091.3_Missense_Mutation_p.G363C|DEPDC5_ENST00000536766.1_Missense_Mutation_p.G335C|DEPDC5_ENST00000400248.1_Missense_Mutation_p.G363C|DEPDC5_ENST00000400242.3_Missense_Mutation_p.G363C			O75140	DEPD5_HUMAN	DEP domain containing 5	363					intracellular signal transduction					breast(1)|central_nervous_system(5)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(24)|ovary(5)|pancreas(2)|prostate(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	63						TTTAGGAATTGGTGTGGATTT	0.393000													7	69					8.12818e-05	0.00274141	8.12818e-05	1	0
STAG3	10734	broad.mit.edu	37	7	99800139	99800139	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr7:99800139G>T	ENST00000426455.1	+	25	3033	c.2626G>T	c.(2626-2628)Ggg>Tgg	p.G876W	STAG3_ENST00000440830.1_3'UTR|GATS_ENST00000436886.2_3'UTR|GATS_ENST00000543273.1_RNA|STAG3_ENST00000394018.2_Missense_Mutation_p.G818W|STAG3_ENST00000317296.5_Missense_Mutation_p.G876W			Q9UJ98	STAG3_HUMAN	stromal antigen 3	876					chromosome segregation|synaptonemal complex assembly	chromosome, centromeric region|meiotic cohesin complex|synaptonemal complex	binding			breast(1)|central_nervous_system(2)|endometrium(6)|kidney(3)|large_intestine(11)|lung(30)|ovary(5)|prostate(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)	66	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					CCTCCTAGCCGGGTTCTGCAA	0.507000													8	163					1.12685e-05	0.000393226	0.000274275	1	0
PHTF2	57157	broad.mit.edu	37	7	77569921	77569921	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr7:77569921G>T	ENST00000416283.2	+	13	1841	c.1715G>T	c.(1714-1716)cGg>cTg	p.R572L	PHTF2_ENST00000275575.7_Missense_Mutation_p.R568L|PHTF2_ENST00000422959.2_Missense_Mutation_p.R572L|PHTF2_ENST00000307305.8_Missense_Mutation_p.R568L|PHTF2_ENST00000248550.7_Missense_Mutation_p.R606L	NM_001127357.1|NM_020432.4	NP_001120829.1|NP_065165.3	Q8N3S3	PHTF2_HUMAN	putative homeodomain transcription factor 2	606					regulation of transcription, DNA-dependent|transcription, DNA-dependent	endoplasmic reticulum|nucleus	DNA binding	p.R572Q(1)|p.R606Q(1)		endometrium(2)|kidney(3)|large_intestine(3)|lung(9)|ovary(1)|prostate(1)	19						CCTCATTTCCGGTTGAAGAAA	0.378000													6	132					8.12818e-05	0.00274141	8.12818e-05	1	0
ANO5	203859	broad.mit.edu	37	11	22279232	22279232	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr11:22279232G>A	ENST00000324559.8	+	14	1656	c.1339G>A	c.(1339-1341)Gaa>Aaa	p.E447K		NM_001142649.1|NM_213599.2	NP_001136121.1|NP_998764.1	Q75V66	ANO5_HUMAN	anoctamin 5	447						chloride channel complex|endoplasmic reticulum membrane	chloride channel activity	p.E447K(1)		breast(2)|central_nervous_system(3)|endometrium(1)|kidney(2)|large_intestine(12)|lung(36)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	63						ACAGGAGATGGAACCTTACAT	0.378000													26	39					0	0	0.000184323	0	0
LTBR	4055	broad.mit.edu	37	12	6495602	6495602	+	Missense_Mutation	SNP	A	A	G			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr12:6495602A>G	ENST00000228918.4	+	6	985	c.659A>G	c.(658-660)gAg>gGg	p.E220G	LTBR_ENST00000543190.1_3'UTR|LTBR_ENST00000541102.1_Missense_Mutation_p.E113G|LTBR_ENST00000539925.1_Missense_Mutation_p.E201G	NM_002342.1	NP_002333.1	P36941	TNR3_HUMAN	lymphotoxin beta receptor (TNFR superfamily, member 3)	220					apoptosis|cellular response to mechanical stimulus|interspecies interaction between organisms|positive regulation of I-kappaB kinase/NF-kappaB cascade	integral to membrane	protein binding|receptor activity			breast(1)|cervix(1)|kidney(2)|large_intestine(4)|lung(4)|ovary(1)|prostate(2)	15						CTGCCCCCAGAGATGTCAGGT	0.547000													6	7					0	0	8.12818e-05	0	0
COL4A3	1285	broad.mit.edu	37	2	228173948	228173948	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr2:228173948G>A	ENST00000396578.3	+	50	4831	c.4669G>A	c.(4669-4671)Gcc>Acc	p.A1557T	AC097662.2_ENST00000433324.1_RNA|AC097662.2_ENST00000396588.2_RNA|AC097662.2_ENST00000439598.2_RNA	NM_000091.4	NP_000082.2	Q01955	CO4A3_HUMAN	collagen, type IV, alpha 3 (Goodpasture antigen)	1557	Collagen IV NC1.|Required for the anti-angiogenic activity of tumstatin.				activation of caspase activity|axon guidance|blood circulation|cell adhesion|cell proliferation|cell surface receptor linked signaling pathway|glomerular basement membrane development|induction of apoptosis|negative regulation of angiogenesis|negative regulation of cell proliferation|sensory perception of sound	collagen type IV	extracellular matrix structural constituent|integrin binding|metalloendopeptidase inhibitor activity			NS(4)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(24)|ovary(1)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	55		all_lung(227;0.00101)|Lung NSC(271;0.00278)|Renal(207;0.0112)|Ovarian(221;0.0129)|all_hematologic(139;0.211)|Esophageal squamous(248;0.247)		Epithelial(121;1.17e-46)|all cancers(144;6.87e-42)|Lung(261;0.0137)|LUSC - Lung squamous cell carcinoma(224;0.0187)		TCCTGCGATCGCCATAGCCGT	0.473000													10	39					0	0	0.000219431	0	0
FLG	2312	broad.mit.edu	37	1	152277266	152277266	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr1:152277266G>C	ENST00000368799.1	-	3	10131	c.10096C>G	c.(10096-10098)Cag>Gag	p.Q3366E	FLG-AS1_ENST00000593011.1_RNA|FLG-AS1_ENST00000420707.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	3366	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TGGTGGCTCTGCTGATGGGGC	0.582000									Ichthyosis				25	177					0	0	5.49717e-05	0	0
CELSR3	1951	broad.mit.edu	37	3	48694142	48694142	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr3:48694142G>C	ENST00000544264.1	-	2	4668	c.4388C>G	c.(4387-4389)cCg>cGg	p.P1463R	CELSR3_ENST00000164024.4_Missense_Mutation_p.P1463R			Q9NYQ7	CELR3_HUMAN	cadherin, EGF LAG seven-pass G-type receptor 3	1463	EGF-like 2; calcium-binding.				homophilic cell adhesion|multicellular organismal development|neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			NS(1)|biliary_tract(1)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(23)|ovary(9)|prostate(6)|skin(7)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	83				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		GGTGAAGCGCGGGCGGCAGAC	0.687000													2	1					0	0	6.4e-05	0	0
ARID4B	51742	broad.mit.edu	37	1	235346105	235346105	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr1:235346105G>A	ENST00000264183.3	-	20	2626	c.2129C>T	c.(2128-2130)tCt>tTt	p.S710F	ARID4B_ENST00000366603.2_Missense_Mutation_p.S710F|ARID4B_ENST00000349213.3_Missense_Mutation_p.S624F	NM_016374.5	NP_057458.4	Q4LE39	ARI4B_HUMAN	AT rich interactive domain 4B (RBP1-like)	710					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|protein binding			NS(1)|breast(2)|large_intestine(2)|lung(1)|ovary(2)	8	Ovarian(103;0.0473)|Breast(184;0.23)	all_cancers(173;0.000782)|Prostate(94;0.0132)|all_epithelial(177;0.0808)|Lung SC(1967;0.24)	OV - Ovarian serous cystadenocarcinoma(106;2.86e-05)			AGAACTTTCAGAAGCTAGAAA	0.373000													16	71					0	0	9.7654e-05	0	0
TIAL1	7073	broad.mit.edu	37	10	121336173	121336173	+	Silent	SNP	C	C	T			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr10:121336173C>T	ENST00000369092.4	-	12	1890	c.582G>A	c.(580-582)ccG>ccA	p.P194P	TIAL1_ENST00000369093.2_Silent_p.P334P|TIAL1_ENST00000436547.2_Silent_p.P317P|TIAL1_ENST00000463089.2_5'UTR			Q01085	TIAR_HUMAN	TIA1 cytotoxic granule-associated RNA binding protein-like 1	317					apoptosis|defense response|induction of apoptosis|regulation of transcription from RNA polymerase II promoter	lysosome|nucleus|stress granule	nucleotide binding|RNA binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(4)|liver(1)|lung(3)|ovary(1)	13		Lung NSC(174;0.094)|all_lung(145;0.123)		all cancers(201;0.00239)|BRCA - Breast invasive adenocarcinoma(275;0.0932)		CTCCATAAGGCGGTACTTGCC	0.428000													26	103					0	0	9.22233e-05	0	0
MTA1	9112	broad.mit.edu	37	14	105930441	105930441	+	Silent	SNP	G	G	T			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr14:105930441G>T	ENST00000331320.7	+	13	1363	c.1149G>T	c.(1147-1149)ccG>ccT	p.P383P	MTA1_ENST00000435036.2_5'UTR|MTA1_ENST00000405646.1_Silent_p.P366P|MTA1_ENST00000406191.1_Silent_p.P383P	NM_001203258.1|NM_004689.3	NP_001190187.1|NP_004680.2	Q13330	MTA1_HUMAN	metastasis associated 1	383					signal transduction	cytoplasm|nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|central_nervous_system(2)|endometrium(3)|kidney(1)|large_intestine(1)|lung(5)|stomach(1)	14		all_cancers(154;0.0293)|all_epithelial(191;0.128)|Melanoma(154;0.155)	OV - Ovarian serous cystadenocarcinoma(23;0.00897)|Epithelial(46;0.026)	Epithelial(152;0.19)		CGGGGGCGCCGGGCCAGAGCC	0.652000													15	40					5.01169e-05	0.00172329	5.01169e-05	1	0
MYO5B	4645	broad.mit.edu	37	18	47421488	47421488	+	Silent	SNP	G	G	C			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr18:47421488G>C	ENST00000285039.7	-	22	3167	c.2868C>G	c.(2866-2868)acC>acG	p.T956T	MYO5B_ENST00000324581.6_Silent_p.T97T	NM_001080467.2	NP_001073936.1	Q9ULV0	MYO5B_HUMAN	myosin VB	956					protein transport	myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			NS(1)|breast(6)|central_nervous_system(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(6)|lung(29)|ovary(3)|pancreas(1)|prostate(1)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(4)	87				READ - Rectum adenocarcinoma(32;0.103)		CTACCTCCATGGTGTATGTTG	0.552000													3	37					0	0	6.4e-05	0	0
KEAP1	9817	broad.mit.edu	37	19	10610177	10610177	+	Missense_Mutation	SNP	T	T	A			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr19:10610177T>A	ENST00000171111.5	-	2	1080	c.533A>T	c.(532-534)cAg>cTg	p.Q178L	KEAP1_ENST00000588024.1_5'UTR|KEAP1_ENST00000393623.2_Missense_Mutation_p.Q178L	NM_203500.1	NP_987096.1	Q14145	KEAP1_HUMAN	kelch-like ECH-associated protein 1	178					regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|midbody|nucleus	protein binding			breast(3)|endometrium(2)|kidney(4)|large_intestine(4)|liver(2)|lung(69)|ovary(2)|pancreas(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	92			OV - Ovarian serous cystadenocarcinoma(20;2.71e-09)|Epithelial(33;2.32e-06)|all cancers(31;1.42e-05)			GGGGTCCAGCTGCTGCACCAG	0.567000													6	9					0	0	8.12818e-05	0	0
UBTD2	92181	broad.mit.edu	37	5	171639129	171639129	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr5:171639129T>C	ENST00000393792.2	-	3	815	c.410A>G	c.(409-411)gAg>gGg	p.E137G		NM_152277.2	NP_689490.2	Q8WUN7	UBTD2_HUMAN	ubiquitin domain containing 2	137						cytoplasm				cervix(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(1)|prostate(1)|skin(1)	10	Renal(175;0.000159)|Lung NSC(126;0.00976)|all_lung(126;0.0156)	Medulloblastoma(196;0.00853)|all_neural(177;0.026)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			ATCCAGAGTCTCTATGTCGCT	0.488000													32	29					0	0	0.000270559	0	0
GAL3ST3	89792	broad.mit.edu	37	11	65810581	65810581	+	Silent	SNP	C	C	T			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr11:65810581C>T	ENST00000312006.4	-	3	974	c.693G>A	c.(691-693)gtG>gtA	p.V231V	GAL3ST3_ENST00000527878.1_Silent_p.V231V	NM_033036.2	NP_149025.1	Q96A11	G3ST3_HUMAN	galactose-3-O-sulfotransferase 3	231					monosaccharide metabolic process|oligosaccharide metabolic process|poly-N-acetyllactosamine metabolic process|proteoglycan biosynthetic process|sulfur compound metabolic process	Golgi cisterna membrane|integral to membrane	3'-phosphoadenosine 5'-phosphosulfate binding|carbohydrate binding|galactosylceramide sulfotransferase activity|proteoglycan sulfotransferase activity			kidney(1)|lung(9)|ovary(2)|skin(2)	14						AAACCTCCTCCACCTGGCGGA	0.662000													6	27					0	0	0.000157383	0	0
OR2T4	127074	broad.mit.edu	37	1	248525876	248525876	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr1:248525876G>C	ENST00000366475.1	+	1	994	c.994G>C	c.(994-996)Gct>Cct	p.A332P		NM_001004696.1	NP_001004696.1	Q8NH00	OR2T4_HUMAN	olfactory receptor, family 2, subfamily T, member 4	332					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(3)|liver(2)|lung(47)	56	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			TGTCATGGGGGCTCTGAAGAA	0.413000													25	109					0	0	7.24521e-05	0	0
RELN	5649	broad.mit.edu	37	7	103207105	103207105	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr7:103207105G>C	ENST00000428762.1	-	32	4849	c.4690C>G	c.(4690-4692)Ctg>Gtg	p.L1564V	RELN_ENST00000343529.5_Missense_Mutation_p.L1564V|RELN_ENST00000424685.2_Missense_Mutation_p.L1564V	NM_005045.3	NP_005036.2	P78509	RELN_HUMAN	reelin	1564					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			NS(3)|breast(8)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(43)|lung(101)|ovary(9)|pancreas(2)|prostate(4)|skin(14)|stomach(2)|upper_aerodigestive_tract(12)|urinary_tract(2)	227				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		TCCTGTGGCAGGTCAATGGAA	0.473000													7	41					0	0	8.12818e-05	0	0
SFSWAP	6433	broad.mit.edu	37	12	132238982	132238982	+	Silent	SNP	C	C	T			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr12:132238982C>T	ENST00000261674.4	+	9	1533	c.1392C>T	c.(1390-1392)gcC>gcT	p.A464A	SFSWAP_ENST00000541286.1_Silent_p.A464A	NM_004592.3	NP_004583.2	Q12872	SFSWA_HUMAN	splicing factor, suppressor of white-apricot homolog (Drosophila)	464					mRNA splice site selection|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding|RNA binding			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(8)|ovary(1)|skin(2)	25						ACAAGCTGGCCGAGTATGTCG	0.557000													4	33					0	0	0.00024832	0	0
EFTUD1	79631	broad.mit.edu	37	15	82512439	82512439	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr15:82512439G>T	ENST00000268206.7	-	13	1592	c.1424C>A	c.(1423-1425)cCa>cAa	p.P475Q	EFTUD1_ENST00000359445.3_Missense_Mutation_p.P424Q	NM_024580.5	NP_078856.4	Q7Z2Z2	ETUD1_HUMAN	elongation factor Tu GTP binding domain containing 1	475					mature ribosome assembly		GTP binding|GTPase activity|ribosome binding|translation elongation factor activity			cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(3)|lung(14)|ovary(1)|pancreas(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	32						CTCTCCTTTTGGACATGTTTC	0.493000													11	121					6.31663e-08	2.39387e-06	0.000308642	1	0
NRCAM	4897	broad.mit.edu	37	7	107866736	107866736	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr7:107866736G>C	ENST00000379028.3	-	9	1107	c.637C>G	c.(637-639)Cgc>Ggc	p.R213G	NRCAM_ENST00000425651.2_Missense_Mutation_p.R213G|NRCAM_ENST00000413765.2_Missense_Mutation_p.R213G|NRCAM_ENST00000379022.4_Missense_Mutation_p.R213G|NRCAM_ENST00000379024.4_Missense_Mutation_p.R213G|NRCAM_ENST00000351718.4_Missense_Mutation_p.R207G			Q92823	NRCAM_HUMAN	neuronal cell adhesion molecule	213	Ig-like 2.				angiogenesis|axon guidance|axonal fasciculation|cell-cell adhesion|central nervous system development|clustering of voltage-gated sodium channels|neuron migration|positive regulation of neuron differentiation|regulation of axon extension|synapse assembly	external side of plasma membrane|integral to plasma membrane	ankyrin binding			breast(4)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(8)|liver(1)|lung(36)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(4)	65						TAGTCTTCGCGGGTGTCCTCT	0.423000													4	154					0	0	1.23904e-05	0	0
CHD8	57680	broad.mit.edu	37	14	21874023	21874023	+	Splice_Site	SNP	C	C	A			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr14:21874023C>A	ENST00000399982.2	-	14	2972	c.2907_splice	c.e14-1	p.E970_splice	CHD8_ENST00000557364.1_Splice_Site_p.E970_splice|CHD8_ENST00000555962.1_Intron|CHD8_ENST00000430710.3_Splice_Site_p.E691_splice	NM_001170629.1	NP_001164100.1	Q9HCK8	CHD8_HUMAN	chromodomain helicase DNA binding protein 8	970	Helicase ATP-binding.				ATP-dependent chromatin remodeling|canonical Wnt receptor signaling pathway|negative regulation of transcription, DNA-dependent|negative regulation of Wnt receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase III promoter|transcription, DNA-dependent	MLL1 complex	ATP binding|beta-catenin binding|DNA binding|DNA helicase activity|DNA-dependent ATPase activity|methylated histone residue binding|p53 binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(4)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(8)|lung(33)|ovary(6)|prostate(7)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	85	all_cancers(95;0.00121)		Epithelial(56;2.55e-06)|all cancers(55;1.73e-05)	GBM - Glioblastoma multiforme(265;0.00424)		ACCTTGTGTTCCTAGAAATGG	0.338000													18	32					9.16793e-09	3.57043e-07	5.01169e-05	1	0
CLSTN2	64084	broad.mit.edu	37	3	140251222	140251222	+	Silent	SNP	C	C	A			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr3:140251222C>A	ENST00000458420.3	+	9	1591	c.1401C>A	c.(1399-1401)acC>acA	p.T467T		NM_022131.2	NP_071414.2	Q9H4D0	CSTN2_HUMAN	calsyntenin 2	467					homophilic cell adhesion	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(13)|liver(1)|lung(42)|pancreas(2)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(1)	87						CTGTGGTAACCTTATACATGG	0.413000										HNSCC(16;0.037)			17	124					5.35267e-07	1.96515e-05	9.7654e-05	1	0
OR11L1	391189	broad.mit.edu	37	1	248004731	248004731	+	Silent	SNP	G	G	A			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr1:248004731G>A	ENST00000355784.2	-	1	523	c.468C>T	c.(466-468)ggC>ggT	p.G156G		NM_001001959.1	NP_001001959.1	Q8NGX0	O11L1_HUMAN	olfactory receptor, family 11, subfamily L, member 1	156					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(4)|kidney(5)|large_intestine(5)|lung(35)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	57	all_cancers(71;8.78e-05)|all_epithelial(71;9.15e-06)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.0786)|Lung NSC(105;0.0858)		OV - Ovarian serous cystadenocarcinoma(106;0.0319)			AAGGCAGAAAGCCTGTGCTGA	0.577000													11	48					0	0	0.000308642	0	0
PTPRH	5794	broad.mit.edu	37	19	55718094	55718094	+	Silent	SNP	T	T	A			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr19:55718094T>A	ENST00000376350.3	-	3	337	c.315A>T	c.(313-315)ggA>ggT	p.G105G	PTPRH_ENST00000588559.1_5'UTR|PTPRH_ENST00000263434.5_Silent_p.G105G	NM_002842.3	NP_002833.3	Q9HD43	PTPRH_HUMAN	protein tyrosine phosphatase, receptor type, H	105	Fibronectin type-III 1.				apoptosis	cytoplasm|integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			breast(2)|central_nervous_system(3)|endometrium(4)|kidney(3)|large_intestine(8)|lung(27)|ovary(2)|prostate(5)|skin(10)|upper_aerodigestive_tract(1)|urinary_tract(2)	67		Renal(1328;0.245)	BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0479)		AGCTATTTACTCCGTCTTTCT	0.498000													14	80					0	0	5.01169e-05	0	0
ASGR2	433	broad.mit.edu	37	17	7017444	7017444	+	Missense_Mutation	SNP	A	A	G			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr17:7017444A>G	ENST00000380952.2	-	2	380	c.116T>C	c.(115-117)tTt>tCt	p.F39S	ASGR2_ENST00000446679.2_Intron|ASGR2_ENST00000254850.7_Intron|ASGR2_ENST00000355035.5_Missense_Mutation_p.F39S	NM_001181.4|NM_001201352.1|NM_080912.3	NP_001172.1|NP_001188281.1|NP_550434.1	P07307	ASGR2_HUMAN	asialoglycoprotein receptor 2	39					cell surface receptor linked signaling pathway|endocytosis	focal adhesion|integral to membrane|nucleolus	asialoglycoprotein receptor activity|protein binding|sugar binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(3)|ovary(1)|skin(3)|stomach(4)	18					Antihemophilic Factor(DB00025)	GCCTTTCAAAAATGGATTTCC	0.537000													10	46					0	0	6.40141e-05	0	0
SEMA3E	9723	broad.mit.edu	37	7	83035320	83035320	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr7:83035320G>C	ENST00000307792.3	-	8	1336	c.869C>G	c.(868-870)gCg>gGg	p.A290G	SEMA3E_ENST00000427262.1_Missense_Mutation_p.A230G	NM_012431.2	NP_036563.1	O15041	SEM3E_HUMAN	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E	290	Sema.				axon guidance	extracellular space|membrane	receptor activity			breast(1)|endometrium(3)|kidney(4)|large_intestine(12)|liver(1)|lung(19)|ovary(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(3)	51		Medulloblastoma(109;0.109)				AACGAGTCTCGCTTTTAGGAA	0.348000													6	154					0	0	0.000157383	0	0
PIKFYVE	200576	broad.mit.edu	37	2	209200049	209200049	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr2:209200049C>T	ENST00000264380.4	+	25	4320	c.4162C>T	c.(4162-4164)Ctt>Ttt	p.L1388F	PIKFYVE_ENST00000474721.1_3'UTR	NM_015040.3	NP_055855.2	Q9Y2I7	FYV1_HUMAN	phosphoinositide kinase, FYVE finger containing	1388					cellular protein metabolic process|intracellular signal transduction|protein localization to nucleus|retrograde transport, endosome to Golgi	early endosome membrane|membrane raft	1-phosphatidylinositol-3-phosphate 5-kinase activity|1-phosphatidylinositol-4-phosphate 5-kinase activity|ATP binding|metal ion binding|protein binding			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(14)|kidney(6)|large_intestine(25)|lung(40)|ovary(7)|pancreas(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	107						CATTCGGCTTCTTGAAGTATG	0.363000													71	134					0	0	0.000147903	0	0
KIAA1551	55196	broad.mit.edu	37	12	32135423	32135423	+	Nonsense_Mutation	SNP	A	A	T			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr12:32135423A>T	ENST00000312561.4	+	4	1948	c.1534A>T	c.(1534-1536)Aag>Tag	p.K512*	KIAA1551_ENST00000535596.1_Intron	NM_018169.3	NP_060639.3			KIAA1551																		CTATTCTGAAAAGCGGCCAAT	0.388000													10	55					0	0	3.86212e-05	0	0
TP53	7157	broad.mit.edu	37	17	7579312	7579312	+	Splice_Site	SNP	C	C	A	rs55863639		TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr17:7579312C>A	ENST00000420246.2	-	4	507	c.375_splice	c.e4+1	p.T125_splice	TP53_ENST00000455263.2_Splice_Site_p.T125_splice|TP53_ENST00000445888.2_Splice_Site_p.T125_splice|TP53_ENST00000413465.2_Splice_Site_p.T125_splice|TP53_ENST00000269305.4_Splice_Site_p.T125_splice|TP53_ENST00000359597.4_Splice_Site_p.T125_splice	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	125	Interaction with AXIN1 (By similarity).|Interaction with HIPK1 (By similarity).|Required for interaction with FBXO42.		T -> A (in a sporadic cancer; somatic mutation).|T -> K (in sporadic cancers; somatic mutation).|T -> M (in sporadic cancers; somatic mutation).|T -> P (in a sporadic cancer; somatic mutation).|T -> R (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.T125T(51)|p.0?(8)|p.?(2)|p.V73fs*9(1)|p.G105_T125del21(1)|p.Y126fs*11(1)|p.P13fs*18(1)|p.T125_Y126insX(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GGCAACTGACCGTGCAAGTCA	0.537000		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			15	25					2.94398e-08	1.12783e-06	9.7654e-05	1	0
PCDHA5	56143	broad.mit.edu	37	5	140202711	140202711	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr5:140202711G>A	ENST00000529859.1	+	1	1351	c.1351G>A	c.(1351-1353)Gct>Act	p.A451T	PCDHA5_ENST00000378126.3_Missense_Mutation_p.A451T|PCDHA5_ENST00000529619.1_Missense_Mutation_p.A451T|PCDHA2_ENST00000526136.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA4_ENST00000512229.2_Intron	NM_018908.2	NP_061731.1														NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(4)|kidney(6)|large_intestine(8)|liver(1)|lung(22)|ovary(2)|prostate(6)|skin(4)|upper_aerodigestive_tract(3)	60			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GAACGACAACGCTCCGGCGTT	0.667000													11	23					0	0	0.000151284	0	0
NELFCD	51497	broad.mit.edu	37	20	57564012	57564012	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr20:57564012G>C	ENST00000602795.1	+	5	542	c.494G>C	c.(493-495)cGg>cCg	p.R165P	NELFCD_ENST00000344018.3_Missense_Mutation_p.R156P					negative elongation factor complex member C/D																		ACCACGTGGCGGGACCTTTTT	0.478000													3	46					0	0	0.00024832	0	0
PIK3CA	5290	broad.mit.edu	37	3	178948153	178948153	+	Missense_Mutation	SNP	A	A	T			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr3:178948153A>T	ENST00000263967.3	+	20	3082	c.2925A>T	c.(2923-2925)agA>agT	p.R975S		NM_006218.2	NP_006209.2	P42336	PK3CA_HUMAN	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha	975	PI3K/PI4K.				epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity			NS(16)|autonomic_ganglia(4)|biliary_tract(22)|bone(1)|breast(2150)|central_nervous_system(110)|cervix(33)|endometrium(473)|eye(1)|haematopoietic_and_lymphoid_tissue(35)|kidney(14)|large_intestine(1202)|liver(42)|lung(202)|meninges(1)|oesophagus(28)|ovary(235)|pancreas(17)|penis(8)|pituitary(12)|prostate(10)|skin(155)|small_intestine(1)|soft_tissue(18)|stomach(121)|thyroid(80)|upper_aerodigestive_tract(70)|urinary_tract(208)	5269	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			CAAAGACAAGAGAATTTGAGA	0.323000		57	Mis		"""colorectal, gastric, gliobastoma, breast"""					HNSCC(19;0.045)|TSP Lung(28;0.18)			12	245					0	0	0.000219431	0	0
RNF213	57674	broad.mit.edu	37	17	78319551	78319551	+	Silent	SNP	C	C	T	rs143772929		TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr17:78319551C>T	ENST00000582970.1	+	29	7559	c.7416C>T	c.(7414-7416)ttC>ttT	p.F2472F	RNF213_ENST00000508628.2_Silent_p.F2521F|RNF213_ENST00000336301.6_Silent_p.F545F	NM_001256071.1	NP_001243000.1	Q9HCF4	ALO17_HUMAN	ring finger protein 213	0										NS(1)|breast(7)|central_nervous_system(1)|cervix(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(23)|lung(36)|ovary(11)|pancreas(2)|prostate(4)|skin(3)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	130	all_neural(118;0.0538)		BRCA - Breast invasive adenocarcinoma(99;0.0252)|OV - Ovarian serous cystadenocarcinoma(97;0.057)			ATGTGGCCTTCGCCAATAAGG	0.463000													12	50					0	0	0.000151284	0	0
GRIP1	23426	broad.mit.edu	37	12	66770984	66770984	+	Silent	SNP	G	G	A			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr12:66770984G>A	ENST00000359742.4	-	21	2943	c.2703C>T	c.(2701-2703)tgC>tgT	p.C901C	GRIP1_ENST00000398016.3_Silent_p.C849C|GRIP1_ENST00000286445.7_Silent_p.C901C			Q9Y3R0	GRIP1_HUMAN	glutamate receptor interacting protein 1	901					androgen receptor signaling pathway|intracellular signal transduction|positive regulation of transcription, DNA-dependent|synaptic transmission	cell junction|cytoplasmic membrane-bounded vesicle|cytosol|endoplasmic reticulum|postsynaptic membrane	androgen receptor binding|beta-catenin binding|protein C-terminus binding|receptor signaling complex scaffold activity|transcription coactivator activity			NS(3)|breast(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(10)|lung(19)|ovary(2)|prostate(2)|skin(1)	50			GBM - Glioblastoma multiforme(2;0.00069)	GBM - Glioblastoma multiforme(28;0.0933)		CTGACTGTCCGCAGGTTTCCA	0.443000													37	166					0	0	0.000270559	0	0
SORCS1	114815	broad.mit.edu	37	10	108469071	108469071	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr10:108469071C>A	ENST00000263054.6	-	7	1060	c.1053G>T	c.(1051-1053)caG>caT	p.Q351H	SORCS1_ENST00000344440.6_Missense_Mutation_p.Q351H	NM_001206570.1|NM_052918.4	NP_001193499.1|NP_443150.3	Q8WY21	SORC1_HUMAN	sortilin-related VPS10 domain containing receptor 1	351						integral to membrane	neuropeptide receptor activity|protein binding			breast(5)|central_nervous_system(1)|cervix(2)|endometrium(9)|kidney(2)|large_intestine(24)|lung(69)|ovary(1)|prostate(8)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	127		Breast(234;0.0256)|Colorectal(252;0.09)|Lung NSC(174;0.168)		Epithelial(162;1.66e-05)|all cancers(201;0.000689)		CTGTACAGTTCTGCATTCGGC	0.403000													16	56					2.4624e-09	9.64302e-08	0.000132079	1	0
FASTKD2	22868	broad.mit.edu	37	2	207651558	207651558	+	Missense_Mutation	SNP	A	A	T			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr2:207651558A>T	ENST00000236980.6	+	8	1877	c.1529A>T	c.(1528-1530)tAc>tTc	p.Y510F	FASTKD2_ENST00000403094.3_Missense_Mutation_p.Y510F|FASTKD2_ENST00000402774.3_Missense_Mutation_p.Y510F	NM_014929.3	NP_055744.2	Q9NYY8	FAKD2_HUMAN	FAST kinase domains 2	510					apoptosis|cellular respiration	mitochondrion	ATP binding|protein kinase activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(7)|ovary(3)|prostate(1)|skin(2)	21				LUSC - Lung squamous cell carcinoma(261;0.0718)|Epithelial(149;0.119)|Lung(261;0.138)		TTGATGAATTACTTTCCCCTG	0.403000													35	80					0	0	0.000228196	0	0
HSPB9	94086	broad.mit.edu	37	17	40275302	40275302	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr17:40275302C>T	ENST00000355067.3	+	1	547	c.434C>T	c.(433-435)cCg>cTg	p.P145L	CTD-2132N18.3_ENST00000592574.1_Intron	NM_033194.2	NP_149971.1	Q9BQS6	HSPB9_HUMAN	heat shock protein, alpha-crystallin-related, B9	145					response to stress	cytoplasm|nucleus	protein binding			haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(2)	4		all_cancers(22;0.00064)|Breast(137;0.00104)|all_epithelial(22;0.00866)		BRCA - Breast invasive adenocarcinoma(366;0.124)		GGACCGTCCCCGAGACTCGGG	0.637000													9	26					0	0	2.17888e-05	0	0
ATP13A4	84239	broad.mit.edu	37	3	193166098	193166098	+	Silent	SNP	C	C	G			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr3:193166098C>G	ENST00000342695.4	-	18	2371	c.2049G>C	c.(2047-2049)ctG>ctC	p.L683L	ATP13A4_ENST00000392443.3_Silent_p.L664L	NM_032279.2	NP_115655.2	Q4VNC1	AT134_HUMAN	ATPase type 13A4	683					ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(9)|lung(27)|ovary(2)|prostate(3)|skin(11)|upper_aerodigestive_tract(2)	71	all_cancers(143;1.76e-08)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(49;2.72e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;0.000109)		CCAGAAATATCAGGTCTGATT	0.408000													33	97					0	0	0.000132358	0	0
ZNF229	7772	broad.mit.edu	37	19	44934288	44934288	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr19:44934288C>G	ENST00000291187.4	-	6	972	c.650G>C	c.(649-651)tGc>tCc	p.C217S	ZNF229_ENST00000588931.1_Missense_Mutation_p.C223S|ZNF229_ENST00000591289.1_Intron|CTC-512J12.4_ENST00000588655.1_RNA	NM_001278510.1	NP_001265439.1	Q9UJW7	ZN229_HUMAN	zinc finger protein 229	223					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(5)|central_nervous_system(2)|endometrium(6)|large_intestine(3)|lung(18)|ovary(1)|pancreas(1)|prostate(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(1)	45		Prostate(69;0.0352)				AGATATCCAGCAAAAGCTGTC	0.378000													5	94					0	0	3.59834e-05	0	0
KCNH8	131096	broad.mit.edu	37	3	19498349	19498349	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr3:19498349C>A	ENST00000328405.2	+	11	2181	c.1915C>A	c.(1915-1917)Ctc>Atc	p.L639I		NM_144633.2	NP_653234.2	Q96L42	KCNH8_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 8	639						integral to membrane	two-component sensor activity			NS(1)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|liver(3)|lung(37)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	77						CTACTGTGATCTCCAGTGTAT	0.403000													21	50					5.26018e-13	2.08309e-11	0.000229342	1	0
CEP85L	387119	broad.mit.edu	37	6	118790380	118790380	+	Silent	SNP	T	T	C	rs77465615		TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr6:118790380T>C	ENST00000368491.3	-	12	2730	c.2109A>G	c.(2107-2109)aaA>aaG	p.K703K	CEP85L_ENST00000368488.5_Silent_p.K706K	NM_001042475.2	NP_001035940.1	Q5SZL2	CF204_HUMAN	centrosomal protein 85kDa-like	703						centrosome											ATAGTGGCCGTTTGGAAAGAA	0.418000													30	99					0	0	7.24521e-05	0	0
TGM7	116179	broad.mit.edu	37	15	43585695	43585695	+	Silent	SNP	G	G	T			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr15:43585695G>T	ENST00000452443.2	-	2	149	c.145C>A	c.(145-147)Cga>Aga	p.R49R		NM_052955.2	NP_443187.1	Q96PF1	TGM7_HUMAN	transglutaminase 7	49					peptide cross-linking		acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(3)|large_intestine(8)|lung(16)|ovary(2)|prostate(4)|skin(1)	39		all_cancers(109;2.12e-14)|all_epithelial(112;1.99e-12)|Lung NSC(122;2.46e-08)|all_lung(180;2.75e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;9.14e-07)	L-Glutamine(DB00130)	TGGAAGGGTCGGCTGAAGCTC	0.617000													27	56					1.38267e-23	5.66653e-22	0.000117367	1	0
PLAA	9373	broad.mit.edu	37	9	26905576	26905576	+	Missense_Mutation	SNP	T	T	A			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr9:26905576T>A	ENST00000397292.3	-	14	2738	c.2321A>T	c.(2320-2322)aAg>aTg	p.K774M		NM_001031689.2	NP_001026859.1	Q9Y263	PLAP_HUMAN	phospholipase A2-activating protein	774	PUL.				phospholipid metabolic process|signal transduction		phospholipase A2 activator activity			breast(1)|endometrium(7)|kidney(2)|large_intestine(3)|lung(3)|prostate(1)	17		all_neural(3;3.53e-10)|Glioma(3;2.71e-09)		Lung(218;1.32e-05)|LUSC - Lung squamous cell carcinoma(38;0.00011)		TGAGGAATACTTTTTTATTTG	0.368000													24	98					0	0	5.49717e-05	0	0
FLNC	2318	broad.mit.edu	37	7	128492757	128492757	+	Silent	SNP	G	G	A			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr7:128492757G>A	ENST00000325888.8	+	36	6216	c.5955G>A	c.(5953-5955)tcG>tcA	p.S1985S	RP11-309L24.2_ENST00000469965.1_RNA|FLNC_ENST00000346177.6_Silent_p.S1952S	NM_001458.4	NP_001449.3	Q14315	FLNC_HUMAN	filamin C, gamma	1985					cell junction assembly	cytoskeleton|cytosol|plasma membrane|sarcomere	actin binding			biliary_tract(1)|breast(7)|central_nervous_system(1)|cervix(1)|endometrium(19)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(19)|lung(59)|ovary(2)|pancreas(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)	128						GTGCCCCCTCGGGCAACGAGG	0.657000													6	22					0	0	0.000157383	0	0
CPED1	79974	broad.mit.edu	37	7	120629688	120629688	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr7:120629688C>G	ENST00000310396.5	+	2	480	c.13C>G	c.(13-15)Cca>Gca	p.P5A	CPED1_ENST00000495036.1_3'UTR|CPED1_ENST00000340646.5_Missense_Mutation_p.P5A|CPED1_ENST00000450913.2_Missense_Mutation_p.P5A	NM_024913.4	NP_079189.4			cadherin-like and PC-esterase domain containing 1																		GGTCTGTCGCCCAGTGTTCCC	0.522000													10	59					0	0	6.40141e-05	0	0
PDZRN4	29951	broad.mit.edu	37	12	41966845	41966845	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr12:41966845C>A	ENST00000298919.7	+	10	1872	c.1484C>A	c.(1483-1485)tCc>tAc	p.S495Y	PDZRN4_ENST00000539469.2_Missense_Mutation_p.S497Y|PDZRN4_ENST00000402685.2_Missense_Mutation_p.S755Y			Q6ZMN7	PZRN4_HUMAN	PDZ domain containing ring finger 4	755							ubiquitin-protein ligase activity|zinc ion binding			breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(23)|lung(29)|ovary(3)|pancreas(1)|prostate(2)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	77	all_cancers(12;0.000673)	Lung NSC(34;0.0205)|all_lung(34;0.0264)				GTAGACCGTTCCCCTGACAGT	0.498000													8	35					1.12685e-05	0.000393226	0.000274275	1	0
CNTNAP2	26047	broad.mit.edu	37	7	147183067	147183067	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr7:147183067C>G	ENST00000361727.3	+	11	2227	c.1711C>G	c.(1711-1713)Caa>Gaa	p.Q571E		NM_014141.5	NP_054860.1	Q9UHC6	CNTP2_HUMAN	contactin associated protein-like 2	571	EGF-like 1.				behavior|cell adhesion|clustering of voltage-gated potassium channels|limbic system development|neuron recognition|signal transduction|striatum development|superior temporal gyrus development|thalamus development|transmission of nerve impulse	axolemma|cell body fiber|dendrite|juxtaparanode region of axon|voltage-gated potassium channel complex	receptor binding			NS(3)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(21)|lung(105)|ovary(9)|pancreas(2)|prostate(5)|skin(7)|stomach(3)|upper_aerodigestive_tract(6)|urinary_tract(3)	188	Melanoma(164;0.153)	all_cancers(3;3.51e-10)|all_epithelial(3;1.4e-05)|Myeloproliferative disorder(3;0.00452)|Lung NSC(3;0.0067)|all_lung(3;0.00794)	OV - Ovarian serous cystadenocarcinoma(82;0.0319)			AAAGTGCTCGCAAACATGGGA	0.443000										HNSCC(39;0.1)			17	77					0	0	9.7654e-05	0	0
MIR519E	574463	broad.mit.edu	37	19	54183211	54183211	+	RNA	SNP	C	C	A			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr19:54183211C>A	ENST00000385075.1	+	0	18					NR_030185.1																						CAGTCATTCTCCAAAAGGGAG	0.373000													13	66					7.93312e-07	2.89744e-05	0.000219431	1	0
MPDZ	8777	broad.mit.edu	37	9	13247788	13247788	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr9:13247788G>T	ENST00000319217.7	-	3	276	c.29C>A	c.(28-30)gCc>gAc	p.A10D	MPDZ_ENST00000381015.4_Missense_Mutation_p.A10D|MPDZ_ENST00000447879.1_Missense_Mutation_p.A10D|MPDZ_ENST00000546205.1_Missense_Mutation_p.A10D|MPDZ_ENST00000536827.1_Missense_Mutation_p.A10D|MPDZ_ENST00000541718.1_Missense_Mutation_p.A10D|MPDZ_ENST00000381022.2_Missense_Mutation_p.A10D	NM_001261406.1	NP_001248335.1	O75970	MPDZ_HUMAN	multiple PDZ domain protein	10	L27.				interspecies interaction between organisms	apical plasma membrane|dendrite|postsynaptic density|postsynaptic membrane|synaptosome|tight junction	protein C-terminus binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(14)|lung(15)|ovary(5)|prostate(7)|stomach(1)|urinary_tract(2)	61				GBM - Glioblastoma multiforme(50;2.03e-06)		TGCATGCAGGGCCCGATTTTT	0.468000													8	200					0.000274275	0.0086698	0.000274275	1	0
MTNR1A	4543	broad.mit.edu	37	4	187455231	187455231	+	Missense_Mutation	SNP	T	T	A			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr4:187455231T>A	ENST00000307161.5	-	2	866	c.665A>T	c.(664-666)aAa>aTa	p.K222I	RP11-215A19.2_ENST00000509111.1_Intron	NM_005958.3	NP_005949.1	P48039	MTR1A_HUMAN	melatonin receptor 1A	222					circadian rhythm|G-protein signaling, coupled to cyclic nucleotide second messenger|mating behavior	integral to plasma membrane	melatonin receptor activity			breast(1)|central_nervous_system(1)|endometrium(3)|large_intestine(1)|lung(4)|ovary(1)|pancreas(1)|prostate(1)|skin(1)	14		all_cancers(14;6.39e-56)|all_epithelial(14;1.48e-41)|all_lung(41;2.45e-15)|Lung NSC(41;7.26e-15)|Melanoma(20;1.91e-06)|Hepatocellular(41;0.00335)|Prostate(90;0.00996)|all_hematologic(60;0.014)|Colorectal(36;0.0161)|Renal(120;0.0183)|all_neural(102;0.202)		OV - Ovarian serous cystadenocarcinoma(60;7.63e-12)|BRCA - Breast invasive adenocarcinoma(30;6.68e-07)|GBM - Glioblastoma multiforme(59;3.44e-05)|LUSC - Lung squamous cell carcinoma(40;0.000106)|STAD - Stomach adenocarcinoma(60;0.000279)|READ - Rectum adenocarcinoma(43;0.159)	Melatonin(DB01065)|Ramelteon(DB00980)	GCGGTCAGGTTTCACCCTCTG	0.478000													14	78					0	0	3.45872e-05	0	0
SLC35G5	83650	broad.mit.edu	37	8	11189001	11189001	+	Missense_Mutation	SNP	A	A	G			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr8:11189001A>G	ENST00000382435.4	+	1	605	c.386A>G	c.(385-387)aAc>aGc	p.N129S		NM_054028.1	NP_473369.1	Q96KT7	AMCL2_HUMAN	solute carrier family 35, member G5	129	DUF6 1.					integral to membrane											CCCGCTGGCAACGCTGCCACT	0.612000													13	57					0	0	0.000151284	0	0
BRINP2	57795	broad.mit.edu	37	1	177250578	177250578	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr1:177250578G>T	ENST00000361539.4	+	8	2578	c.2266G>T	c.(2266-2268)Gtg>Ttg	p.V756L	FAM5B_ENST00000478325.1_3'UTR	NM_021165.2	NP_066988.1	Q9C0B6	FAM5B_HUMAN		756						extracellular region		p.V756M(1)		breast(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(21)|liver(1)|lung(41)|ovary(2)|prostate(1)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(1)	94						CAACAATGAGGTGGGCAGGAT	0.557000													5	42					1.024e-07	3.85999e-06	1.23904e-05	1	0
RHBDL3	162494	broad.mit.edu	37	17	30621436	30621436	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr17:30621436C>A	ENST00000269051.4	+	5	657	c.643C>A	c.(643-645)Ctg>Atg	p.L215M	RHBDL3_ENST00000538145.1_Missense_Mutation_p.L207M|RHBDL3_ENST00000536287.1_Missense_Mutation_p.L117M	NM_138328.2	NP_612201.1	P58872	RHBL3_HUMAN	rhomboid, veinlet-like 3 (Drosophila)	215					proteolysis	integral to membrane	calcium ion binding|serine-type endopeptidase activity			breast(1)|endometrium(1)|large_intestine(5)|lung(5)|ovary(1)|prostate(2)|skin(1)	16		Breast(31;0.116)|Ovarian(249;0.182)				TTGGCGCTACCTGACATACAT	0.463000													9	36					1.12685e-05	0.000393226	0.000274275	1	0
NFIB	4781	broad.mit.edu	37	9	14146797	14146797	+	Silent	SNP	G	G	T			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr9:14146797G>T	ENST00000380959.3	-	6	1289	c.816C>A	c.(814-816)ccC>ccA	p.P272P	NFIB_ENST00000380953.1_Silent_p.P272P|NFIB_ENST00000397579.2_Silent_p.P272P|NFIB_ENST00000380934.4_Silent_p.P298P|NFIB_ENST00000397581.2_Silent_p.P272P|NFIB_ENST00000380924.1_Silent_p.P20P|NFIB_ENST00000397575.3_Silent_p.P272P|NFIB_ENST00000543693.1_Silent_p.P20P	NM_005596.3	NP_005587.2	O00712	NFIB_HUMAN	nuclear factor I/B	272					anterior commissure morphogenesis|chondrocyte differentiation|Clara cell differentiation|commissural neuron axon guidance|DNA replication|glial cell differentiation|lung ciliated cell differentiation|negative regulation of DNA binding|negative regulation of epithelial cell proliferation involved in lung morphogenesis|negative regulation of mesenchymal cell proliferation involved in lung development|positive regulation of transcription from RNA polymerase II promoter|principal sensory nucleus of trigeminal nerve development|Type I pneumocyte differentiation|Type II pneumocyte differentiation	cerebellar mossy fiber|nucleolus|nucleus	RNA polymerase II transcription corepressor activity|sequence-specific DNA binding RNA polymerase II transcription factor activity			central_nervous_system(2)|endometrium(2)|large_intestine(7)|lung(5)|skin(1)	17				GBM - Glioblastoma multiforme(50;4.4e-08)|LUAD - Lung adenocarcinoma(58;0.119)|Lung(218;0.164)		ATATAGTTTTGGGTCTTTTGC	0.378000			T	"""MYB, HGMA2"""	"""adenoid cystic carcinoma, lipoma"""								10	223					0.00010058	0.00336013	0.00010058	1	0
NKAPL	222698	broad.mit.edu	37	6	28227756	28227756	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr6:28227756G>C	ENST00000343684.3	+	1	659	c.607G>C	c.(607-609)Gat>Cat	p.D203H		NM_001007531.1	NP_001007532.1	Q5M9Q1	NKAPL_HUMAN	NFKB activating protein-like	203	Lys-rich.									breast(2)|endometrium(2)|kidney(1)|large_intestine(8)|lung(8)|ovary(2)|prostate(4)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	31						GAAATATTCTGATAGTGACAG	0.333000													19	51					0	0	0.000375601	0	0
COPZ1	22818	broad.mit.edu	37	12	54744287	54744287	+	Missense_Mutation	SNP	A	A	G			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr12:54744287A>G	ENST00000262061.2	+	9	551	c.514A>G	c.(514-516)Aag>Gag	p.K172E	COPZ1_ENST00000455864.2_Missense_Mutation_p.K149E|COPZ1_ENST00000416254.2_Missense_Mutation_p.K121E|COPZ1_ENST00000549043.1_Missense_Mutation_p.K180E|COPZ1_ENST00000552362.1_Missense_Mutation_p.K155E|COPZ1_ENST00000552218.1_Missense_Mutation_p.K193E|COPZ1_ENST00000549116.1_Missense_Mutation_p.K114E|COPZ1_ENST00000551779.1_3'UTR|COPZ1_ENST00000548753.1_Missense_Mutation_p.K84E|COPZ1_ENST00000548281.1_3'UTR	NM_001271734.1|NM_001271736.1|NM_016057.1	NP_001258663.1|NP_001258665.1|NP_057141.1	P61923	COPZ1_HUMAN	coatomer protein complex, subunit zeta 1	172					COPI coating of Golgi vesicle|intra-Golgi vesicle-mediated transport|intracellular protein transport|retrograde vesicle-mediated transport, Golgi to ER	COPI vesicle coat|cytosol				kidney(1)|lung(4)	5						AGAACAGATCAAGTGGTCACT	0.493000													8	112					0	0	0.00010058	0	0
SRSF4	6429	broad.mit.edu	37	1	29475099	29475099	+	Silent	SNP	G	G	T			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr1:29475099G>T	ENST00000373795.4	-	6	1542	c.1308C>A	c.(1306-1308)acC>acA	p.T436T	SRSF4_ENST00000546138.1_3'UTR	NM_005626.4	NP_005617.2	Q08170	SRSF4_HUMAN	serine/arginine-rich splicing factor 4	436	Arg/Ser-rich (RS domain).			TNQ -> RNE (in Ref. 1; AAA36649).	mRNA 3'-end processing|mRNA export from nucleus|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	nuclear speck	nucleotide binding|RNA binding			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(8)|liver(1)|lung(8)|ovary(1)|prostate(1)	27						TCTCCTGATTGGTGCCAGCAT	0.522000													9	134					4.68919e-08	1.78671e-06	3.86212e-05	1	0
ZNF649	65251	broad.mit.edu	37	19	52394790	52394790	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr19:52394790T>C	ENST00000354957.3	-	5	883	c.599A>G	c.(598-600)cAt>cGt	p.H200R	ZNF649_ENST00000600738.1_Missense_Mutation_p.H200R|CTC-429C10.2_ENST00000600329.1_RNA	NM_023074.3	NP_075562.2	Q9BS31	ZN649_HUMAN	zinc finger protein 649	200					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(12)|ovary(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)	29		all_neural(266;0.0602)		GBM - Glioblastoma multiforme(134;0.00152)|OV - Ovarian serous cystadenocarcinoma(262;0.0185)		CTTTCCTGTATGAATTCTCTT	0.463000													11	45					0	0	3.86212e-05	0	0
PRH1	5554	broad.mit.edu	37	12	11035684	11035684	+	Nonsense_Mutation	SNP	C	C	A			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr12:11035684C>A	ENST00000428168.2	-	2	113	c.76G>T	c.(76-78)Gaa>Taa	p.E26*	PRR4_ENST00000536668.1_5'UTR	NM_006250.3	NP_006241.2	P02810	PRPC_HUMAN	proline-rich protein HaeIII subfamily 1	26	Inhibits hydroxyapatite formation, binds to hydroxyapatite and calcium.					extracellular space	protein binding			endometrium(1)|kidney(1)|lung(2)|upper_aerodigestive_tract(1)	5				BRCA - Breast invasive adenocarcinoma(232;0.245)		GGAACATCTTCCTGGCTGACA	0.398000													15	54					2.94398e-08	1.12783e-06	9.7654e-05	1	0
COX10	1352	broad.mit.edu	37	17	14005488	14005488	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr17:14005488G>T	ENST00000261643.3	+	4	630	c.553G>T	c.(553-555)Gac>Tac	p.D185Y	COX10_ENST00000536205.1_Intron|COX10_ENST00000537334.1_5'UTR	NM_001303.3	NP_001294.2	Q12887	COX10_HUMAN	cytochrome c oxidase assembly homolog 10 (yeast)	185					heme a biosynthetic process|heme O biosynthetic process|respiratory chain complex IV assembly	integral to membrane|mitochondrial membrane	protoheme IX farnesyltransferase activity			cervix(1)|endometrium(3)|large_intestine(2)|lung(5)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	14		all_lung(20;0.06)|Lung SC(565;0.168)		UCEC - Uterine corpus endometrioid carcinoma (92;0.106)		GGGCCCTTTTGACTGGCCCTG	0.498000													8	110					1.58986e-06	5.74715e-05	3.86212e-05	1	0
COL4A4	1286	broad.mit.edu	37	2	227920692	227920692	+	Silent	SNP	A	A	G			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr2:227920692A>G	ENST00000396625.3	-	30	2892	c.2685T>C	c.(2683-2685)gaT>gaC	p.D895D	COL4A4_ENST00000329662.7_Silent_p.D895D	NM_000092.4	NP_000083.3	P53420	CO4A4_HUMAN	collagen, type IV, alpha 4	895	Triple-helical region.				axon guidance|glomerular basement membrane development	basal lamina|collagen type IV	extracellular matrix structural constituent|protein binding			breast(2)|central_nervous_system(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(15)|lung(35)|ovary(5)|pancreas(3)|prostate(2)|skin(12)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	98		Renal(207;0.00844)|all_lung(227;0.0187)|Lung NSC(271;0.0879)|all_hematologic(139;0.21)|Esophageal squamous(248;0.242)		Epithelial(121;6.7e-11)|all cancers(144;5.39e-08)|Lung(261;0.0132)|LUSC - Lung squamous cell carcinoma(224;0.0181)		GTAGCCCATCATCTCCAAAGG	0.582000													5	18					0	0	1.23904e-05	0	0
NUPL2	11097	broad.mit.edu	37	7	23240136	23240136	+	Silent	SNP	G	G	C			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr7:23240136G>C	ENST00000258742.5	+	7	1303	c.1044G>C	c.(1042-1044)ccG>ccC	p.P348P		NM_007342.2	NP_031368.1	O15504	NUPL2_HUMAN	nucleoporin like 2	348	Ser-rich.				carbohydrate metabolic process|glucose transport|mRNA transport|protein export from nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear membrane|nuclear pore	nuclear export signal receptor activity|nucleic acid binding|zinc ion binding			breast(1)|endometrium(1)|kidney(3)|large_intestine(3)|lung(4)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	19						TTGGTAGTCCGGGCTCACATT	0.507000													4	95					0	0	0.00024832	0	0
NUP98	4928	broad.mit.edu	37	11	3726504	3726504	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr11:3726504G>A	ENST00000324932.7	-	22	3428	c.3008C>T	c.(3007-3009)gCa>gTa	p.A1003V	NUP98_ENST00000355260.3_Missense_Mutation_p.A1003V|NUP98_ENST00000359171.4_Missense_Mutation_p.A1003V	NM_016320.4|NM_139132.3	NP_057404.2|NP_624358.2	P52948	NUP98_HUMAN	nucleoporin 98kDa	1020					carbohydrate metabolic process|DNA replication|glucose transport|interspecies interaction between organisms|mitotic prometaphase|mRNA transport|nuclear pore organization|protein import into nucleus, docking|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear membrane|nucleoplasm|Nup107-160 complex	protein binding|structural constituent of nuclear pore|transporter activity			NS(1)|autonomic_ganglia(1)|breast(8)|central_nervous_system(1)|endometrium(5)|kidney(5)|large_intestine(13)|liver(1)|lung(15)|ovary(2)|prostate(2)|skin(9)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	66		Medulloblastoma(188;0.0025)|Breast(177;0.00328)|all_neural(188;0.0227)		BRCA - Breast invasive adenocarcinoma(625;0.0403)|LUSC - Lung squamous cell carcinoma(625;0.116)|Lung(200;0.199)		AGAAGTATCTGCTTTGGAAGG	0.413000			T	"""HOXA9, NSD1, WHSC1L1, DDX10, TOP1, HOXD13, PMX1, HOXA13, HOXD11, HOXA11, RAP1GDS1, HOXC11"""	AML								26	62					0	0	9.22233e-05	0	0
OR5B12	390191	broad.mit.edu	37	11	58206944	58206944	+	Silent	SNP	G	G	C			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr11:58206944G>C	ENST00000302572.2	-	1	702	c.681C>G	c.(679-681)cgC>cgG	p.R227R		NM_001004733.2	NP_001004733.1	Q96R08	OR5BC_HUMAN	olfactory receptor, family 5, subfamily B, member 12	227					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(6)|liver(1)|lung(28)|ovary(1)|prostate(3)|skin(1)	40	Esophageal squamous(5;0.0027)	Breast(21;0.0778)				CTTCAGGTGAGCGCATCTTCA	0.398000													3	45					0	0	6.4e-05	0	0
CNTNAP4	85445	broad.mit.edu	37	16	76501310	76501310	+	Nonsense_Mutation	SNP	T	T	A			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr16:76501310T>A	ENST00000307431.8	+	11	1927	c.1542T>A	c.(1540-1542)tgT>tgA	p.C514*	CNTNAP4_ENST00000469589.1_3'UTR|CNTNAP4_ENST00000377504.4_Nonsense_Mutation_p.C466*|CNTNAP4_ENST00000476707.1_Nonsense_Mutation_p.C518*|CNTNAP4_ENST00000478060.1_Nonsense_Mutation_p.C442*	NM_033401.3	NP_207837.2	Q9C0A0	CNTP4_HUMAN	contactin associated protein-like 4	515	Laminin G-like 2.				cell adhesion|signal transduction	integral to membrane	receptor binding			breast(4)|central_nervous_system(1)|cervix(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(6)|lung(33)|ovary(2)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(1)	64						TTCAGGGATGTATGAGGCTCA	0.433000													11	25					0	0	6.40141e-05	0	0
PSG7	5676	broad.mit.edu	37	19	43430684	43430684	+	RNA	SNP	G	G	C			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr19:43430684G>C	ENST00000446844.3	-	0	983				PSG7_ENST00000406070.2_RNA			Q13046	PSG7_HUMAN	pregnancy specific beta-1-glycoprotein 7 (gene/pseudogene)						female pregnancy	extracellular region							Prostate(69;0.00682)				TCGTGACACTGGGTAGAATGA	0.502000													4	116					0	0	1.23904e-05	0	0
ABCB4	5244	broad.mit.edu	37	7	87069700	87069700	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr7:87069700C>A	ENST00000265723.4	-	13	1486	c.1375G>T	c.(1375-1377)Gat>Tat	p.D459Y	ABCB4_ENST00000359206.3_Missense_Mutation_p.D459Y|ABCB4_ENST00000358400.3_Missense_Mutation_p.D459Y|ABCB4_ENST00000545634.1_Missense_Mutation_p.D459Y|ABCB4_ENST00000453593.1_Missense_Mutation_p.D459Y	NM_000443.3|NM_018849.2	NP_000434.1|NP_061337.1	P21439	MDR3_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 4	459	ABC transporter 1.				cellular lipid metabolic process	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus|membrane fraction	ATP binding|xenobiotic-transporting ATPase activity			breast(5)|endometrium(7)|kidney(2)|large_intestine(15)|lung(32)|ovary(4)|pancreas(2)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	77	Esophageal squamous(14;0.0058)|all_lung(186;0.201)|Lung NSC(181;0.203)					TTCCTAATATCCTGCCCATCA	0.348000													9	46					5.68852e-11	2.24013e-09	0.000274275	1	0
RBAK	57786	broad.mit.edu	37	7	5103754	5103754	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr7:5103754C>G	ENST00000396912.1	+	5	1186	c.667C>G	c.(667-669)Cat>Gat	p.H223D	RBAK_ENST00000396904.2_Intron|RBAK_ENST00000407184.1_Intron|RBAK_ENST00000353796.3_Missense_Mutation_p.H223D	NM_021163.3	NP_066986.1	Q9NYW8	RBAK_HUMAN	RB-associated KRAB zinc finger	223	Required for interaction with RB1.				negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			NS(1)|kidney(1)|large_intestine(2)|ovary(4)|skin(1)|upper_aerodigestive_tract(1)	10		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0916)|OV - Ovarian serous cystadenocarcinoma(56;2.44e-14)		TTTTATTGCTCATAAGAGAGC	0.348000													12	45					0	0	0.00010058	0	0
MUC17	140453	broad.mit.edu	37	7	100681270	100681270	+	Silent	SNP	T	T	C			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr7:100681270T>C	ENST00000306151.4	+	3	6637	c.6573T>C	c.(6571-6573)ccT>ccC	p.P2191P		NM_001040105.1	NP_001035194.1	Q685J3	MUC17_HUMAN	mucin 17, cell surface associated	2191	59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			NS(3)|breast(14)|central_nervous_system(2)|cervix(2)|endometrium(27)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(28)|lung(179)|ovary(19)|pancreas(1)|prostate(13)|skin(26)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	343	Lung NSC(181;0.136)|all_lung(186;0.182)					CCAGCACACCTGTGACCAATT	0.483000													21	192					0	0	0.000375601	0	0
MOK	5891	broad.mit.edu	37	14	102717262	102717262	+	Silent	SNP	C	C	G	rs142858806		TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr14:102717262C>G	ENST00000361847.2	-	7	708	c.477G>C	c.(475-477)acG>acC	p.T159T	MOK_ENST00000524214.1_Silent_p.T129T|MOK_ENST00000522874.1_Silent_p.T158T|MOK_ENST00000193029.6_5'UTR	NM_014226.1	NP_055041.1	Q9UQ07	MOK_HUMAN	MOK protein kinase	159	Protein kinase.				signal transduction	Golgi apparatus	ATP binding|cyclin-dependent protein kinase activity|protein binding										AGATGTATTCCGTGTACGGCT	0.557000													3	49					0	0	0.00024832	0	0
TUSC3	7991	broad.mit.edu	37	8	15519695	15519695	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr8:15519695G>T	ENST00000382020.4	+	5	806	c.598G>T	c.(598-600)Ggt>Tgt	p.G200C	TUSC3_ENST00000503731.1_Missense_Mutation_p.G200C|TUSC3_ENST00000506802.1_Missense_Mutation_p.G200C|TUSC3_ENST00000503191.1_3'UTR|TUSC3_ENST00000509380.1_Missense_Mutation_p.G200C	NM_178234.2	NP_839952.1	Q13454	TUSC3_HUMAN	tumor suppressor candidate 3	200					cell redox homeostasis|post-translational protein modification|protein N-linked glycosylation via asparagine	integral to membrane|oligosaccharyltransferase complex				breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(10)|lung(10)|ovary(2)	28				Colorectal(111;0.113)		CAACTACTCTGGTACCATTGC	0.368000													8	117					0.000274275	0.0086698	0.000274275	1	0
MON2	23041	broad.mit.edu	37	12	62938684	62938684	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr12:62938684C>T	ENST00000393630.3	+	22	2867	c.2476C>T	c.(2476-2478)Cag>Tag	p.Q826*	MON2_ENST00000393629.2_Nonsense_Mutation_p.Q825*|MON2_ENST00000552738.1_Nonsense_Mutation_p.Q802*|MON2_ENST00000393632.2_Nonsense_Mutation_p.Q825*|MON2_ENST00000552115.1_Nonsense_Mutation_p.Q825*|MON2_ENST00000280379.6_Nonsense_Mutation_p.Q826*|MON2_ENST00000546600.1_Nonsense_Mutation_p.Q825*	NM_001278470.1|NM_001278472.1	NP_001265399.1|NP_001265401.1	Q7Z3U7	MON2_HUMAN	MON2 homolog (S. cerevisiae)	826					Golgi to endosome transport|protein transport	cytoplasm	ARF guanyl-nucleotide exchange factor activity|binding			NS(1)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(5)|kidney(3)|large_intestine(15)|lung(21)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	57			BRCA - Breast invasive adenocarcinoma(9;0.218)	GBM - Glioblastoma multiforme(28;0.128)		TCAGGTCTGCCAGCATCCAAA	0.333000													12	40					0	0	0.00010058	0	0
SLC22A5	6584	broad.mit.edu	37	5	131714117	131714117	+	Silent	SNP	C	C	T			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr5:131714117C>T	ENST00000245407.3	+	2	662	c.441C>T	c.(439-441)tcC>tcT	p.S147S	SLC22A5_ENST00000435065.2_Silent_p.S171S	NM_003060.3	NP_003051.1	O76082	S22A5_HUMAN	solute carrier family 22 (organic cation/carnitine transporter), member 5	147					positive regulation of intestinal epithelial structure maintenance|quorum sensing involved in interaction with host|sodium ion transport|sodium-dependent organic cation transport	apical plasma membrane|brush border membrane|integral to membrane	ATP binding|carnitine transporter activity|PDZ domain binding|symporter activity			NS(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(2)|stomach(1)	8		all_cancers(142;0.0751)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)		L-Carnitine(DB00583)	TCACAATCTCCTTGTTCTTCG	0.507000													18	117					0	0	0.000295444	0	0
ANPEP	290	broad.mit.edu	37	15	90347556	90347556	+	Silent	SNP	G	G	A			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr15:90347556G>A	ENST00000300060.6	-	6	1420	c.1107C>T	c.(1105-1107)ttC>ttT	p.F369F		NM_001150.2	NP_001141.2	P15144	AMPN_HUMAN	alanyl (membrane) aminopeptidase	369	Metalloprotease.				angiogenesis|cell differentiation|interspecies interaction between organisms	cytosol|ER-Golgi intermediate compartment|integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|receptor activity|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|liver(1)|lung(20)|ovary(3)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(3)	57	Lung NSC(78;0.0221)|all_lung(78;0.0448)		BRCA - Breast invasive adenocarcinoma(143;0.0146)|KIRC - Kidney renal clear cell carcinoma(17;0.0286)|Kidney(142;0.0514)|STAD - Stomach adenocarcinoma(125;0.169)		Ezetimibe(DB00973)	ACAGGGGGTCGAACAGCAGGG	0.632000													7	28					0	0	0.000274275	0	0
SLC35F2	54733	broad.mit.edu	37	11	107682478	107682478	+	Missense_Mutation	SNP	T	T	A			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr11:107682478T>A	ENST00000525071.1	-	6	917	c.329A>T	c.(328-330)aAg>aTg	p.K110M	SLC35F2_ENST00000525815.1_Missense_Mutation_p.K110M|SLC35F2_ENST00000265836.7_De_novo_Start_InFrame|SLC35F2_ENST00000375682.4_Missense_Mutation_p.K63M|SLC35F2_ENST00000429869.1_Missense_Mutation_p.K110M			Q8IXU6	S35F2_HUMAN	solute carrier family 35, member F2	110					transport	integral to membrane				breast(1)|central_nervous_system(1)|endometrium(1)|lung(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	8		all_cancers(61;9.46e-06)|Acute lymphoblastic leukemia(157;3.97e-05)|Melanoma(852;0.000111)|all_hematologic(158;0.000315)|all_epithelial(67;0.00197)|Breast(348;0.104)		BRCA - Breast invasive adenocarcinoma(274;3.28e-05)|Epithelial(105;0.000105)|all cancers(92;0.00217)		CAGGATGTACTTCCACCATTT	0.418000													33	122					0	0	0.000228196	0	0
PADI2	11240	broad.mit.edu	37	1	17422438	17422438	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr1:17422438C>G	ENST00000375486.4	-	4	440	c.377G>C	c.(376-378)cGg>cCg	p.R126P	PADI2_ENST00000375481.1_Missense_Mutation_p.R126P|PADI2_ENST00000444885.2_Missense_Mutation_p.R126P	NM_007365.2	NP_031391.2	Q9Y2J8	PADI2_HUMAN	peptidyl arginine deiminase, type II	126					peptidyl-citrulline biosynthetic process from peptidyl-arginine	cytoplasm	calcium ion binding|protein-arginine deiminase activity			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(12)|ovary(4)|pancreas(1)|skin(5)|urinary_tract(3)	29		Colorectal(325;3.46e-05)|Breast(348;0.000162)|Lung NSC(340;0.000422)|Renal(390;0.000518)|all_lung(284;0.000546)|Ovarian(437;0.00671)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00583)|BRCA - Breast invasive adenocarcinoma(304;1.49e-05)|COAD - Colon adenocarcinoma(227;1.54e-05)|Kidney(64;0.000258)|KIRC - Kidney renal clear cell carcinoma(64;0.00348)|STAD - Stomach adenocarcinoma(196;0.0072)|READ - Rectum adenocarcinoma(331;0.0698)|Lung(427;0.201)	L-Citrulline(DB00155)	CACACCATCCCGGTCTGCGTC	0.612000													3	50					0	0	6.4e-05	0	0
PLVAP	83483	broad.mit.edu	37	19	17476149	17476149	+	Silent	SNP	G	G	T			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr19:17476149G>T	ENST00000252590.4	-	3	1186	c.1125C>A	c.(1123-1125)ctC>ctA	p.L375L		NM_031310.1	NP_112600.1	Q9BX97	PLVAP_HUMAN	plasmalemma vesicle associated protein	375						caveola|integral to membrane|perinuclear region of cytoplasm				cervix(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(14)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	27						GCTCCATCCTGAGCTGCTCCG	0.617000													15	40					8.00594e-06	0.00028502	9.7654e-05	1	0
STXBP4	252983	broad.mit.edu	37	17	53084882	53084882	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr17:53084882G>T	ENST00000376352.2	+	8	797	c.590G>T	c.(589-591)tGg>tTg	p.W197L	STXBP4_ENST00000299341.4_Missense_Mutation_p.W122L|STXBP4_ENST00000398391.2_Missense_Mutation_p.W122L|STXBP4_ENST00000405898.1_Missense_Mutation_p.W197L|STXBP4_ENST00000434978.2_Missense_Mutation_p.W197L	NM_178509.5	NP_848604.3	Q6ZWJ1	STXB4_HUMAN	syntaxin binding protein 4	197						cytoplasm	calcium ion binding			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(8)|lung(4)|ovary(1)|upper_aerodigestive_tract(2)	19						GCTTCTGCCTGGACTGAAAAT	0.368000													13	427					1.49906e-05	0.000520535	0.000219431	1	0
MUC16	94025	broad.mit.edu	37	19	9069845	9069845	+	Silent	SNP	A	A	G			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr19:9069845A>G	ENST00000397910.4	-	3	17804	c.17601T>C	c.(17599-17601)ccT>ccC	p.P5867P		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	5869	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TAGTCCCTATAGGACCTGTTT	0.493000													3	79					0	0	6.4e-05	0	0
CNTRL	11064	broad.mit.edu	37	9	123911032	123911032	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr9:123911032G>A	ENST00000373855.1	+	24	3802	c.3542G>A	c.(3541-3543)cGc>cAc	p.R1181H	CNTRL_ENST00000373847.1_Missense_Mutation_p.R629H|CNTRL_ENST00000373850.1_Missense_Mutation_p.R629H|CNTRL_ENST00000238341.5_Missense_Mutation_p.R1181H			Q7Z7A1	CNTRL_HUMAN	centriolin	1181					cell division|G2/M transition of mitotic cell cycle	centrosome|cytosol	protein binding			haematopoietic_and_lymphoid_tissue(2)|large_intestine(9)|lung(2)|ovary(4)|skin(3)	20						AGAAAACCACGCCCTGGGCAG	0.512000													11	56					0	0	0.00010058	0	0
XIRP2	129446	broad.mit.edu	37	2	168107879	168107879	+	Missense_Mutation	SNP	T	T	A			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr2:168107879T>A	ENST00000409195.1	+	9	10066	c.9977T>A	c.(9976-9978)gTg>gAg	p.V3326E	XIRP2_ENST00000409273.1_Missense_Mutation_p.V3104E|XIRP2_ENST00000420519.1_Intron|XIRP2_ENST00000409756.2_Intron|XIRP2_ENST00000295237.9_Missense_Mutation_p.V3326E|XIRP2_ENST00000409605.1_Intron|XIRP2_ENST00000409728.1_Intron|XIRP2_ENST00000409043.1_Intron	NM_152381.5	NP_689594.4	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2	3151					actin cytoskeleton organization	cell junction	actin binding			NS(3)|biliary_tract(2)|breast(5)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(51)|lung(160)|ovary(7)|pancreas(3)|prostate(11)|skin(14)|stomach(5)|upper_aerodigestive_tract(8)|urinary_tract(7)	315						GAAAATTTCGTGAATGACCCT	0.443000													7	78					0	0	0.000157383	0	0
PTS	5805	broad.mit.edu	37	11	112101363	112101363	+	Silent	SNP	G	G	C			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr11:112101363G>C	ENST00000280362.3	+	4	280	c.201G>C	c.(199-201)acG>acC	p.T67T	PTS_ENST00000525803.1_Intron|PTS_ENST00000524931.1_5'UTR	NM_000317.2	NP_000308.1	Q03393	PTPS_HUMAN	6-pyruvoyltetrahydropterin synthase	67			T -> M (in HPABH4A).		cellular amino acid metabolic process|central nervous system development|tetrahydrobiopterin biosynthetic process	mitochondrion	6-pyruvoyltetrahydropterin synthase activity|metal ion binding			breast(1)|large_intestine(1)	2		all_cancers(61;2.51e-14)|all_epithelial(67;1.64e-08)|Melanoma(852;8.81e-06)|all_hematologic(158;0.000405)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0112)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		Epithelial(105;1.27e-06)|BRCA - Breast invasive adenocarcinoma(274;1.43e-06)|all cancers(92;2.1e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.0519)		ACCCTGCTACGGGAATGGTTA	0.383000													3	77					0	0	0.00024832	0	0
PEG3	5178	broad.mit.edu	37	19	57328305	57328305	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr19:57328305C>T	ENST00000326441.9	-	10	1868	c.1505G>A	c.(1504-1506)gGg>gAg	p.G502E	PEG3_ENST00000598410.1_Missense_Mutation_p.G378E|ZIM2_ENST00000599935.1_Intron|ZIM2_ENST00000601070.1_Intron|ZIM2_ENST00000593711.1_Intron|ZIM2_ENST00000391708.3_Intron|PEG3_ENST00000593695.1_Missense_Mutation_p.G376E|PEG3_ENST00000423103.2_Missense_Mutation_p.G502E|ZIM2_ENST00000221722.5_Intron	NM_006210.2	NP_006201.1	Q9GZU2	PEG3_HUMAN	paternally expressed 3	502					apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|biliary_tract(4)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(27)|lung(84)|ovary(8)|pancreas(5)|prostate(6)|skin(8)|stomach(2)|upper_aerodigestive_tract(6)	170		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)		AAAACGTTTCCCTCCAACCTG	0.453000													15	83					0	0	0.000132079	0	0
RGL1	23179	broad.mit.edu	37	1	183895366	183895366	+	Silent	SNP	G	G	A			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr1:183895366G>A	ENST00000304685.3	+	19	2813	c.2352G>A	c.(2350-2352)acG>acA	p.T784T	RGL1_ENST00000367531.1_Silent_p.T784T|RGL1_ENST00000360851.3_Silent_p.T749T|RGL1_ENST00000536277.1_Silent_p.T747T|RGL1_ENST00000539189.1_Silent_p.T720T	NM_015149.3	NP_055964.3	Q9NZL6	RGL1_HUMAN	ral guanine nucleotide dissociation stimulator-like 1	749					cellular lipid metabolic process|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	intracellular	protein binding|Ral guanyl-nucleotide exchange factor activity			breast(5)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(12)|liver(1)|lung(17)|ovary(4)|prostate(3)|stomach(1)	51						CCAGCTTGACGTTGCCCAGGA	0.502000													23	32					0	0	5.49717e-05	0	0
CDH11	1009	broad.mit.edu	37	16	65005485	65005485	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr16:65005485G>A	ENST00000394156.3	-	11	2092	c.1639C>T	c.(1639-1641)Cga>Tga	p.R547*	CDH11_ENST00000566827.1_Nonsense_Mutation_p.R421*|CDH11_ENST00000268603.4_Nonsense_Mutation_p.R547*			P55287	CAD11_HUMAN	cadherin 11, type 2, OB-cadherin (osteoblast)	547	Cadherin 5.				adherens junction organization|cell junction assembly|homophilic cell adhesion|ossification|skeletal system development	integral to membrane|plasma membrane	calcium ion binding|protein binding	p.R547G(1)		NS(1)|breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(5)|kidney(5)|large_intestine(19)|lung(40)|ovary(3)|prostate(3)|skin(2)|urinary_tract(2)	88		Ovarian(137;0.0973)		OV - Ovarian serous cystadenocarcinoma(108;0.205)		TACAAACCTCGGTTGTCTCTG	0.398000			T	USP6	aneurysmal bone cysts					TSP Lung(24;0.17)			10	50					0	0	6.40141e-05	0	0
AHNAK	79026	broad.mit.edu	37	11	62287710	62287710	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr11:62287710C>T	ENST00000378024.4	-	5	14453	c.14179G>A	c.(14179-14181)Gac>Aac	p.D4727N	AHNAK_ENST00000257247.7_Intron|AHNAK_ENST00000530124.1_Intron	NM_001620.1	NP_001611.1	Q09666	AHNK_HUMAN	AHNAK nucleoprotein	4727					nervous system development	nucleus	protein binding			NS(3)|autonomic_ganglia(1)|breast(10)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(33)|large_intestine(40)|liver(1)|lung(108)|ovary(13)|pancreas(4)|prostate(5)|skin(16)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(6)	268		Melanoma(852;0.155)				AGGTTTAAGTCAATATCAGGC	0.498000													12	117					0	0	0.000151284	0	0
PEX2	5828	broad.mit.edu	37	8	77896369	77896369	+	Nonsense_Mutation	SNP	T	T	A			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr8:77896369T>A	ENST00000419564.2	-	4	510	c.46A>T	c.(46-48)Aga>Tga	p.R16*	PEX2_ENST00000357039.4_Nonsense_Mutation_p.R16*|PEX2_ENST00000520103.1_Nonsense_Mutation_p.R16*|PEX2_ENST00000522527.1_Nonsense_Mutation_p.R16*	NM_001172087.1	NP_001165558.1	P28328	PEX2_HUMAN	peroxisomal biogenesis factor 2	16					peroxisome organization	integral to peroxisomal membrane	protein binding|zinc ion binding			NS(1)|breast(2)|endometrium(1)|kidney(1)|large_intestine(2)|lung(6)|ovary(1)	14						TGGCTTATTCTTAGCACTCTG	0.423000													14	104					0	0	7.07596e-05	0	0
NR0B1	190	broad.mit.edu	37	X	30322942	30322942	+	Splice_Site	SNP	T	T	A			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chrX:30322942T>A	ENST00000378970.4	-	2	1403		c.e2-2			NM_000475.4	NP_000466.2	P51843	NR0B1_HUMAN	nuclear receptor subfamily 0, group B, member 1						adrenal gland development|hypothalamus development|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of steroid hormone receptor signaling pathway|pituitary gland development|protein localization|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|steroid biosynthetic process	cytoplasm|membrane fraction|nucleoplasm|nucleus|polysomal ribosome	AF-2 domain binding|DNA hairpin binding|ligand-regulated transcription factor activity|protein domain specific binding|protein homodimerization activity|RNA binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|steroid hormone receptor binding|transcription corepressor activity|transcription factor binding			central_nervous_system(2)|endometrium(2)|large_intestine(4)|lung(13)|ovary(1)|skin(2)	24					Dexamethasone(DB01234)|Tretinoin(DB00755)	CCGGCACGTCTGGAGGGAGAA	0.473000													5	7					0	0	1.23904e-05	0	0
TFB1M	51106	broad.mit.edu	37	6	155632378	155632378	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr6:155632378C>A	ENST00000367166.4	-	2	284	c.229G>T	c.(229-231)Gac>Tac	p.D77Y	TFB1M_ENST00000480390.1_5'UTR	NM_016020.3	NP_057104.2	Q8WVM0	TFB1M_HUMAN	transcription factor B1, mitochondrial	77					regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrial nucleoid	DNA binding|protein binding|rRNA (adenine-N6,N6-)-dimethyltransferase activity			lung(11)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	16		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;1.48e-12)|BRCA - Breast invasive adenocarcinoma(81;0.0131)		TCAGCGACGTCGGCATTAAGA	0.438000													22	61					1.96895e-08	7.62589e-07	0.000375601	1	0
FRMPD2	143162	broad.mit.edu	37	10	49409355	49409355	+	Missense_Mutation	SNP	T	T	A			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr10:49409355T>A	ENST00000374201.3	-	15	2172	c.1870A>T	c.(1870-1872)Agt>Tgt	p.S624C	FRMPD2_ENST00000305531.3_Missense_Mutation_p.S599C|FRMPD2_ENST00000407470.4_Missense_Mutation_p.S592C	NM_001018071.3	NP_001018081.3	Q68DX3	FRPD2_HUMAN	FERM and PDZ domain containing 2	624	FERM.			S -> G (in Ref. 3; CAH18097).	tight junction assembly	basolateral plasma membrane|cytoplasm|cytoskeleton|tight junction	1-phosphatidylinositol binding|protein binding			NS(2)|autonomic_ganglia(2)|breast(5)|cervix(1)|endometrium(3)|kidney(7)|large_intestine(15)|lung(24)|ovary(2)|prostate(1)|skin(3)|urinary_tract(1)	66				Kidney(211;0.201)		AAGTATTTACTGGTCTTGGCT	0.448000													9	73					0	0	3.86212e-05	0	0
CPS1	1373	broad.mit.edu	37	2	211539654	211539654	+	Missense_Mutation	SNP	T	T	A			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr2:211539654T>A	ENST00000233072.5	+	35	4326	c.4130T>A	c.(4129-4131)gTg>gAg	p.V1377E	CPS1_ENST00000451903.2_Missense_Mutation_p.V926E|CPS1_ENST00000430249.2_Missense_Mutation_p.V1383E	NM_001875.4	NP_001866.2	P31327	CPSM_HUMAN	carbamoyl-phosphate synthase 1, mitochondrial	1377					carbamoyl phosphate biosynthetic process|citrulline biosynthetic process|glutamine metabolic process|glycogen catabolic process|nitric oxide metabolic process|positive regulation of vasodilation|response to lipopolysaccharide|triglyceride catabolic process|urea cycle	mitochondrial nucleoid	ATP binding|carbamoyl-phosphate synthase (ammonia) activity			breast(1)|central_nervous_system(4)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(17)|lung(85)|ovary(8)|pancreas(1)|prostate(6)|skin(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	142				Epithelial(149;0.00697)|Lung(261;0.0521)|LUSC - Lung squamous cell carcinoma(261;0.0544)|all cancers(144;0.0843)		TTCCTTGGTGTGGCTGAACAA	0.343000													18	121					0	0	0.000229342	0	0
GPRASP2	114928	broad.mit.edu	37	X	101969805	101969805	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chrX:101969805G>C	ENST00000543253.1	+	5	927	c.8G>C	c.(7-9)gGg>gCg	p.G3A	GPRASP2_ENST00000535209.1_Missense_Mutation_p.G3A|GPRASP2_ENST00000332262.5_Missense_Mutation_p.G3A	NM_001004051.3|NM_001184874.2|NM_001184876.2	NP_001004051.1|NP_001171803.1|NP_001171805.1			G protein-coupled receptor associated sorting protein 2											breast(3)|endometrium(5)|kidney(2)|large_intestine(6)|lung(12)|ovary(1)|upper_aerodigestive_tract(1)	30						accatgactGGGGCAGAGATT	0.498000													3	39					0	0	6.4e-05	0	0
COL16A1	1307	broad.mit.edu	37	1	32165642	32165642	+	Splice_Site	SNP	C	C	T			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr1:32165642C>T	ENST00000373672.3	-	3	664	c.148_splice	c.e3+1	p.G50_splice	COL16A1_ENST00000373668.3_Splice_Site_p.G50_splice|COL16A1_ENST00000271069.6_Splice_Site_p.G50_splice	NM_001856.3	NP_001847.3	Q07092	COGA1_HUMAN	collagen, type XVI, alpha 1	50	TSP N-terminal.				cell adhesion|female pregnancy|integrin-mediated signaling pathway	collagen type XVI	integrin binding|structural molecule activity			breast(4)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(7)|lung(15)|ovary(8)|prostate(4)	48		Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0423)|all_neural(195;0.0837)|Breast(348;0.116)		STAD - Stomach adenocarcinoma(196;0.059)		GGGTGCTCACCAGTCACGTTG	0.572000													11	21					0	0	0.000151284	0	0
GSC	145258	broad.mit.edu	37	14	95234883	95234883	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr14:95234883G>A	ENST00000238558.3	-	3	928	c.719C>T	c.(718-720)gCg>gTg	p.A240V		NM_173849.2	NP_776248.1	P56915	GSC_HUMAN	goosecoid homeobox	240					gastrulation|middle ear morphogenesis		sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			skin(1)	1		all_cancers(154;0.0896)|all_epithelial(191;0.219)		COAD - Colon adenocarcinoma(157;0.202)|Epithelial(152;0.239)		CTCCGGTGACGCCTTCGACGA	0.572000													13	105					0	0	0.000219431	0	0
VWF	7450	broad.mit.edu	37	12	6220090	6220090	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr12:6220090C>A	ENST00000261405.5	-	4	519	c.265G>T	c.(265-267)Ggg>Tgg	p.G89W	VWF_ENST00000572068.1_Missense_Mutation_p.G126W	NM_000552.3	NP_000543.2	P04275	VWF_HUMAN	von Willebrand factor	89	VWFD 1.				blood coagulation, intrinsic pathway|cell-substrate adhesion|platelet activation|platelet degranulation|protein homooligomerization	endoplasmic reticulum|platelet alpha granule lumen|proteinaceous extracellular matrix|Weibel-Palade body	chaperone binding|collagen binding|glycoprotein binding|immunoglobulin binding|integrin binding|protease binding|protein homodimerization activity|protein N-terminus binding			NS(1)|breast(6)|central_nervous_system(5)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(25)|lung(41)|ovary(7)|pancreas(2)|prostate(6)|skin(15)|stomach(1)|upper_aerodigestive_tract(5)	129					Antihemophilic Factor(DB00025)	AAAAATTCCCCAAGATACACG	0.428000													7	81					0.000274275	0.0086698	0.000274275	1	0
HSD17B7P2	158160	broad.mit.edu	37	10	38654432	38654432	+	RNA	SNP	A	A	G	rs2257765		TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr10:38654432A>G	ENST00000494540.1	+	0	599					NR_003086.1																						TCATCTCGCAATGCAAGGAAA	0.453000													5	64					0	0	3.59834e-05	0	0
SORCS1	114815	broad.mit.edu	37	10	108469072	108469072	+	Missense_Mutation	SNP	T	T	G			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr10:108469072T>G	ENST00000263054.6	-	7	1059	c.1052A>C	c.(1051-1053)cAg>cCg	p.Q351P	SORCS1_ENST00000344440.6_Missense_Mutation_p.Q351P	NM_001206570.1|NM_052918.4	NP_001193499.1|NP_443150.3	Q8WY21	SORC1_HUMAN	sortilin-related VPS10 domain containing receptor 1	351						integral to membrane	neuropeptide receptor activity|protein binding			breast(5)|central_nervous_system(1)|cervix(2)|endometrium(9)|kidney(2)|large_intestine(24)|lung(69)|ovary(1)|prostate(8)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	127		Breast(234;0.0256)|Colorectal(252;0.09)|Lung NSC(174;0.168)		Epithelial(162;1.66e-05)|all cancers(201;0.000689)		TGTACAGTTCTGCATTCGGCA	0.408000													15	56					0	0	9.7654e-05	0	0
XIRP1	165904	broad.mit.edu	37	3	39227609	39227609	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr3:39227609C>A	ENST00000340369.3	-	2	3556	c.3328G>T	c.(3328-3330)Gat>Tat	p.D1110Y	XIRP1_ENST00000421646.1_Intron|XIRP1_ENST00000396251.1_Missense_Mutation_p.D1110Y	NM_194293.2	NP_919269.2	Q702N8	XIRP1_HUMAN	xin actin-binding repeat containing 1	1110							actin binding			breast(4)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(14)|lung(22)|ovary(4)|pancreas(1)|prostate(2)|skin(6)	71				KIRC - Kidney renal clear cell carcinoma(284;0.0517)|Kidney(284;0.065)		ATCCGGGGATCACTTCCACCC	0.607000													12	28					6.40141e-05	0.00219046	6.40141e-05	1	0
ELAVL2	1993	broad.mit.edu	37	9	23704954	23704954	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr9:23704954C>G	ENST00000397312.2	-	4	723	c.449G>C	c.(448-450)cGc>cCc	p.R150P	ELAVL2_ENST00000380110.4_Missense_Mutation_p.R179P|ELAVL2_ENST00000380117.1_Missense_Mutation_p.R150P|ELAVL2_ENST00000223951.6_Missense_Mutation_p.R150P|ELAVL2_ENST00000544538.1_Missense_Mutation_p.R150P	NM_004432.3	NP_004423.2	Q12926	ELAV2_HUMAN	ELAV like neuron-specific RNA binding protein 2	150	RRM 2.				regulation of transcription, DNA-dependent		mRNA 3'-UTR binding|nucleotide binding|protein binding			breast(1)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(20)|ovary(2)|skin(1)|stomach(1)|urinary_tract(1)	39				GBM - Glioblastoma multiforme(1;2.18e-156)|Lung(42;2.15e-28)|LUSC - Lung squamous cell carcinoma(38;1.02e-19)		AGTAATAATGCGTCCATATTG	0.423000													9	120					0	0	0.000274275	0	0
YWHAG	7532	broad.mit.edu	37	7	75958917	75958917	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr7:75958917C>T	ENST00000307630.3	-	2	943	c.721G>A	c.(721-723)Gat>Aat	p.D241N		NM_012479.3	NP_036611.2	P61981	1433G_HUMAN	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide	241					G2/M transition of mitotic cell cycle|regulation of neuron differentiation|regulation of signal transduction|regulation of synaptic plasticity	cytosol	insulin-like growth factor receptor binding|protein kinase C binding|protein kinase C inhibitor activity			endometrium(2)|large_intestine(1)|lung(2)|ovary(2)|prostate(1)	8						TCGCCGCCATCGTCGTCCTGC	0.587000													8	8					0	0	0.000274275	0	0
CAMSAP2	23271	broad.mit.edu	37	1	200822401	200822401	+	Splice_Site	SNP	A	A	G			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr1:200822401A>G	ENST00000358823.2	+	13	3872		c.e13-1		CAMSAP2_ENST00000413307.2_Splice_Site|CAMSAP2_ENST00000236925.4_Splice_Site	NM_203459.1	NP_982284.1	Q08AD1	CAMP2_HUMAN	calmodulin regulated spectrin-associated protein family, member 2							cytoplasm|microtubule	protein binding										TTGATTTCTTAGGCGTAAAAC	0.358000													3	109					0	0	0.00024832	0	0
LRRIQ3	127255	broad.mit.edu	37	1	74575212	74575213	+	Frame_Shift_Ins	INS	-	-	T			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr1:74575212_74575213insT	ENST00000354431.4	-	5	923_924	c.732_733insA	c.(730-735)aaagcafs	p.A245fs	LRRIQ3_ENST00000395089.1_Frame_Shift_Ins_p.A245fs|LRRIQ3_ENST00000370909.2_Frame_Shift_Ins_p.A137fs|LRRIQ3_ENST00000468759.1_5'UTR	NM_001105659.1	NP_001099129.1	A6PVS8	LRIQ3_HUMAN	leucine-rich repeats and IQ motif containing 3	245				QQEKII -> TAGKNY (in Ref. 1; BAD18621).						NS(2)|breast(1)|central_nervous_system(2)|endometrium(7)|kidney(5)|large_intestine(13)|liver(1)|lung(27)|ovary(3)|prostate(1)|skin(5)|soft_tissue(1)|upper_aerodigestive_tract(5)	73						TTTTCCTGCTGTTTTTTTTTGT	0.327													7	132	---	---	---	---					
SEMA3F	6405	broad.mit.edu	37	3	50212549	50212549	+	Frame_Shift_Del	DEL	T	T	-			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr3:50212549delT	ENST00000002829.3	+	6	961	c.477delT	c.(475-477)acfs	p.T159fs	SEMA3F_ENST00000413852.1_Intron|SEMA3F_ENST00000434342.1_Intron	NM_004186.3	NP_004177.3	Q13275	SEM3F_HUMAN	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F	159	Sema.			Missing (in Ref. 2).	axon guidance	extracellular space|membrane	chemorepellent activity|receptor activity			central_nervous_system(1)|kidney(1)|large_intestine(2)|lung(9)|ovary(1)|prostate(1)|skin(2)	17				BRCA - Breast invasive adenocarcinoma(193;0.00013)|KIRC - Kidney renal clear cell carcinoma(197;0.00599)|Kidney(197;0.00688)		GGACCCAGACTCAGGCGGTCA	0.697													2	4	---	---	---	---					
RP11-608O21.1	0	broad.mit.edu	37	4	19815895	19815896	+	RNA	DEL	AA	AA	-	rs145239076		TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr4:19815895_19815896delAA	ENST00000511431.1	+	0	288																											TCTGGGCTGTaaaaaaaaaaaa	0.411													2	4	---	---	---	---					
CDKL2	8999	broad.mit.edu	37	4	76539579	76539580	+	Frame_Shift_Ins	INS	-	-	T			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr4:76539579_76539580insT	ENST00000429927.2	-	3	925_926	c.222_223insA	c.(220-225)aagatgfs	p.M75fs	CDKL2_ENST00000307465.4_Frame_Shift_Ins_p.M75fs	NM_003948.3	NP_003939.1	Q92772	CDKL2_HUMAN	cyclin-dependent kinase-like 2 (CDC2-related kinase)	75	Protein kinase.				sex differentiation|signal transduction	cytoplasm|nucleus	ATP binding|cyclin-dependent protein kinase activity			breast(3)|endometrium(1)|large_intestine(4)|lung(6)|ovary(2)|prostate(2)|skin(2)|stomach(2)	22			Lung(101;0.0973)|LUSC - Lung squamous cell carcinoma(112;0.122)			AGGTACCATCGTTTTTTTTTCT	0.322													7	300	---	---	---	---					
FABP6	2172	broad.mit.edu	37	5	159659192	159659192	+	Frame_Shift_Del	DEL	A	A	-			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr5:159659192delA	ENST00000393980.4	+	5	448	c.302delA	c.(301-303)cgfs	p.Q101fs	FABP6_ENST00000393982.1_Frame_Shift_Del_p.Q101fs|FABP6_ENST00000402432.3_Frame_Shift_Del_p.Q52fs	NM_001130958.1	NP_001124430.1	P51161	FABP6_HUMAN	fatty acid binding protein 6, ileal	52					bile acid and bile salt transport|bile acid metabolic process|negative regulation of cell proliferation	cytosol	transporter activity			breast(1)|kidney(1)|large_intestine(1)|lung(2)	5	Renal(175;0.00196)	Medulloblastoma(196;0.0354)|all_neural(177;0.116)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			ACTTGGTCCCAGCACTACTCC	0.567													2	4	---	---	---	---					
UPF2	26019	broad.mit.edu	37	10	12001252	12001253	+	Frame_Shift_Ins	INS	-	-	T			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr10:12001252_12001253insT	ENST00000356352.2	-	11	2760_2761	c.2287_2288insA	c.(2287-2289)cgtfs	p.R763fs	UPF2_ENST00000357604.5_Frame_Shift_Ins_p.R763fs|UPF2_ENST00000397053.2_Frame_Shift_Ins_p.R763fs			Q9HAU5	RENT2_HUMAN	UPF2 regulator of nonsense transcripts homolog (yeast)	763	Sufficient for interaction with EIF4A1 and EIF1.|Sufficient for interaction with UPF3A and UPF3B.				mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	exon-exon junction complex|perinuclear region of cytoplasm	identical protein binding|RNA binding			breast(3)|central_nervous_system(3)|cervix(1)|endometrium(5)|kidney(6)|large_intestine(14)|lung(17)|ovary(2)|skin(3)|urinary_tract(2)	56		Renal(717;0.228)				CTTTTTCACGGTTTTTTCAGCT	0.416													17	115	---	---	---	---					
SOCS7	30837	broad.mit.edu	37	17	36508743	36508743	+	Frame_Shift_Del	DEL	C	C	-			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr17:36508743delC	ENST00000577233.1	+	1	616	c.616delC	c.(616-618)ggfs	p.R206fs	SOCS7_ENST00000331159.5_Frame_Shift_Del_p.R206fs	NM_014598.2	NP_055413.1	O14512	SOCS7_HUMAN	suppressor of cytokine signaling 7	206	Mediates interaction with SORBS3.				intracellular signal transduction|negative regulation of signal transduction|regulation of growth	cytoplasm|nucleus|plasma membrane	protein binding|SH3 domain binding			central_nervous_system(1)|endometrium(1)|kidney(1)|prostate(1)|skin(5)	9	Breast(7;3.47e-17)					GGGTCCTTCTCGGAAGGGCTC	0.697													2	4	---	---	---	---					
SIN3B	23309	broad.mit.edu	37	19	16977273	16977273	+	Frame_Shift_Del	DEL	C	C	-			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr19:16977273delC	ENST00000379803.1	+	13	1822	c.1808delC	c.(1807-1809)tcfs	p.S603fs	SIN3B_ENST00000595541.1_Frame_Shift_Del_p.S161fs|SIN3B_ENST00000248054.5_Frame_Shift_Del_p.S571fs	NM_015260.2	NP_056075.1	O75182	SIN3B_HUMAN	SIN3 transcription regulator family member B	603					cellular lipid metabolic process|transcription, DNA-dependent	nucleoplasm	protein binding			endometrium(4)|kidney(2)|large_intestine(8)|lung(8)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	26						TACCTCAAGTCCCTTGACCAC	0.587													8	26	---	---	---	---					
ZNF784	147808	broad.mit.edu	37	19	56133788	56133789	+	Frame_Shift_Ins	INS	-	-	C			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr19:56133788_56133789insC	ENST00000325351.4	-	2	339_340	c.300_301insG	c.(298-303)ccgccgfs	p.P101fs	ZNF784_ENST00000591479.1_3'UTR	NM_203374.1	NP_976308.1	Q8NCA9	ZN784_HUMAN	zinc finger protein 784	101					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.S101fs*140(1)		upper_aerodigestive_tract(1)	1			BRCA - Breast invasive adenocarcinoma(297;0.18)	GBM - Glioblastoma multiforme(193;0.105)		TGGCACCGGCTCGGGTCCCCAC	0.728													3	4	---	---	---	---					
IGLV3-12	28802	broad.mit.edu	37	22	23114748	23114749	+	RNA	INS	-	-	T	rs58165270		TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr22:23114748_23114749insT	ENST00000390313.2	+	0	55																											CCATCCTCTCCTTTTTTTTTTT	0.495													6	10	---	---	---	---					
RNA5-8SP6	100873336	broad.mit.edu	37	Y	10037863	10037863	+	RNA	DEL	C	C	-			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chrY:10037863delC	ENST00000515896.1	+	0	100																											ATCGACACTTCGAACGCACTT	0.552													2	4	---	---	---	---