Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
TTN	7273	broad.mit.edu	37	2	179444088	179444088	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr2:179444088C>T	ENST00000589042.1	-	320	67893	c.67669G>A	c.(67669-67671)Gat>Aat	p.D22557N	TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.D20916N|TTN-AS1_ENST00000590932.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000586831.1_RNA|TTN-AS1_ENST00000586707.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.D13492N|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000592600.1_RNA|RP11-171I2.2_ENST00000603521.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.D13684N|TTN-AS1_ENST00000456053.1_RNA|TTN-AS1_ENST00000438095.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.D13617N|TTN_ENST00000342992.6_Missense_Mutation_p.D19989N	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	20916	Fibronectin type-III 63.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TAGCACAAATCAGGTAGACCC	0.413000													5	57					0	0	1	0	0
PARP8	79668	broad.mit.edu	37	5	50091226	50091226	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr5:50091226C>G	ENST00000281631.5	+	12	1561	c.1403C>G	c.(1402-1404)tCt>tGt	p.S468C	PARP8_ENST00000503750.2_Missense_Mutation_p.S468C|PARP8_ENST00000511363.2_3'UTR|PARP8_ENST00000505554.1_Missense_Mutation_p.S447C|PARP8_ENST00000514342.2_Missense_Mutation_p.S221C|PARP8_ENST00000505697.2_Missense_Mutation_p.S468C|PARP8_ENST00000514067.2_Missense_Mutation_p.S468C	NM_001178056.1|NM_024615.3	NP_001171527.1|NP_078891.2	Q8N3A8	PARP8_HUMAN	poly (ADP-ribose) polymerase family, member 8	468	Poly-Ser.					intracellular	NAD+ ADP-ribosyltransferase activity			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(10)|lung(23)|ovary(1)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	49		Lung NSC(810;0.0305)|Breast(144;0.222)				CTAACACCATCTTCATCTTCA	0.408000													6	70					0	0	1	0	0
TLK1	9874	broad.mit.edu	37	2	171902835	171902835	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr2:171902835C>T	ENST00000442919.2	-	11	1489	c.874G>A	c.(874-876)Gaa>Aaa	p.E292K	TLK1_ENST00000360843.3_Missense_Mutation_p.E361K|TLK1_ENST00000521943.1_Missense_Mutation_p.E292K|TLK1_ENST00000434911.2_Missense_Mutation_p.E244K|TLK1_ENST00000431350.2_Missense_Mutation_p.E340K	NM_012290.4	NP_036422.3	Q9UKI8	TLK1_HUMAN	tousled-like kinase 1	340					cell cycle|chromatin modification|intracellular protein transport|intracellular signal transduction|regulation of chromatin assembly or disassembly|response to DNA damage stimulus	nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(8)|liver(3)|lung(10)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	33						CTTTGCCTTTCAATATCTTCC	0.378000													7	115					0	0	1	0	0
FRMD5	84978	broad.mit.edu	37	15	44181013	44181013	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr15:44181013C>G	ENST00000417257.1	-	9	962	c.786G>C	c.(784-786)caG>caC	p.Q262H	FRMD5_ENST00000402883.1_Missense_Mutation_p.Q262H|FRMD5_ENST00000484674.1_Intron	NM_032892.3	NP_116281.2	Q7Z6J6	FRMD5_HUMAN	FERM domain containing 5	262	FERM.					cytoplasm|cytoskeleton|extrinsic to membrane|integral to membrane	cytoskeletal protein binding			breast(2)|cervix(1)|endometrium(2)|large_intestine(1)|lung(5)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	14		all_cancers(109;2.29e-15)|all_epithelial(112;9.98e-13)|Lung NSC(122;4.89e-08)|all_lung(180;5.08e-07)|Melanoma(134;0.0275)		all cancers(107;8.63e-20)|GBM - Glioblastoma multiforme(94;3.63e-06)		TCACCTCTTTCTGACTTACGT	0.502000													17	105					0	0	1	0	0
RFX7	64864	broad.mit.edu	37	15	56387730	56387730	+	Silent	SNP	C	C	T			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr15:56387730C>T	ENST00000423270.1	-	9	2195	c.2196G>A	c.(2194-2196)ttG>ttA	p.L732L	RFX7_ENST00000317318.6_Silent_p.L732L|RFX7_ENST00000559447.2_Silent_p.L635L|RFX7_ENST00000422057.1_Silent_p.L635L	NM_022841.5	NP_073752.5	Q2KHR2	RFX7_HUMAN	regulatory factor X, 7	635					regulation of transcription, DNA-dependent	nucleus	DNA binding			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(3)|lung(7)|skin(1)|upper_aerodigestive_tract(1)	19						CAGAGGAATTCAAGGGTTGAT	0.413000													4	57					0	0	1	0	0
TMC5	79838	broad.mit.edu	37	16	19501762	19501762	+	Silent	SNP	C	C	T			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr16:19501762C>T	ENST00000396229.2	+	18	3368	c.2619C>T	c.(2617-2619)ctC>ctT	p.L873L	TMC5_ENST00000564959.1_Silent_p.L556L|TMC5_ENST00000561503.1_Silent_p.L514L|TMC5_ENST00000542583.2_Silent_p.L873L|TMC5_ENST00000541464.1_Silent_p.L821L|TMC5_ENST00000381414.4_Intron|TMC5_ENST00000219821.5_Silent_p.L627L	NM_001105248.1	NP_001098718.1	Q6UXY8	TMC5_HUMAN	transmembrane channel-like 5	873						integral to membrane				NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(3)|liver(2)|lung(12)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	31						GTCTGCCTCTCTTCATTCACT	0.483000													4	195					0	0	1	0	0
KIT	3815	broad.mit.edu	37	4	55603419	55603419	+	Silent	SNP	G	G	A			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr4:55603419G>A	ENST00000288135.5	+	20	2872	c.2775G>A	c.(2773-2775)gaG>gaA	p.E925E		NM_000222.2|NM_001093772.1	NP_000213.1|NP_001087241.1	P10721	KIT_HUMAN	v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog	925	Protein kinase.				male gonad development|transmembrane receptor protein tyrosine kinase signaling pathway	extracellular space|integral to membrane	ATP binding|protein binding|receptor signaling protein tyrosine kinase activity			NS(8)|autonomic_ganglia(1)|bone(21)|breast(2)|central_nervous_system(4)|endometrium(10)|eye(12)|genital_tract(18)|haematopoietic_and_lymphoid_tissue(1820)|kidney(17)|large_intestine(17)|lung(27)|ovary(23)|pancreas(4)|prostate(1)|salivary_gland(15)|skin(228)|soft_tissue(4117)|stomach(3)|testis(55)|thymus(7)|upper_aerodigestive_tract(1)	6411	all_cancers(7;0.00453)|all_lung(4;0.000565)|Lung NSC(11;0.00129)|all_epithelial(27;0.0104)|Glioma(25;0.08)|all_neural(26;0.101)		LUSC - Lung squamous cell carcinoma(32;0.000276)|Epithelial(7;0.209)	Colorectal(1;0.0276)|COAD - Colon adenocarcinoma(1;0.171)	Dasatinib(DB01254)|Imatinib(DB00619)|Sorafenib(DB00398)|Sunitinib(DB01268)	AGCTAATTGAGAAGCAGATTT	0.468000		1	"""Mis, O"""		"""GIST, AML, TGCT, mastocytosis, mucosal melanoma"""	"""GIST, epithelioma"""	Piebald trait		Piebaldism;Mast Cell disease, Familial Clustering of;Gastrointestinal Stromal Tumors, Sporadic Multiple Primary;Familial Gastrointestinal Stromal Tumors				4	105					0	0	1	0	0
GAB4	128954	broad.mit.edu	37	22	17472947	17472947	+	Silent	SNP	G	G	A			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr22:17472947G>A	ENST00000400588.1	-	2	401	c.294C>T	c.(292-294)ctC>ctT	p.L98L	GAB4_ENST00000523144.1_5'UTR	NM_001037814.1	NP_001032903.1	Q2WGN9	GAB4_HUMAN	GRB2-associated binding protein family, member 4	98	PH.									breast(2)|endometrium(2)|kidney(2)|large_intestine(6)|lung(24)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	44		all_epithelial(15;0.112)|Lung NSC(13;0.248)				GCTGCTCACAGAGGTTCAGGT	0.488000													13	343					0	0	1	0	0
COMTD1	118881	broad.mit.edu	37	10	76994481	76994481	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr10:76994481C>T	ENST00000372538.3	-	6	605	c.523G>A	c.(523-525)Gag>Aag	p.E175K	COMTD1_ENST00000460899.1_5'UTR	NM_144589.2	NP_653190.2	Q86VU5	CMTD1_HUMAN	catechol-O-methyltransferase domain containing 1	175						integral to membrane	O-methyltransferase activity			central_nervous_system(1)|large_intestine(1)|lung(1)	3	all_cancers(46;0.0642)|all_epithelial(25;0.00604)|Prostate(51;0.0112)|Ovarian(15;0.183)					GTGCCGGCCTCGCCCGCCGCC	0.746000													5	12					0	0	1	0	0
DNMT1	1786	broad.mit.edu	37	19	10257139	10257139	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr19:10257139C>G	ENST00000340748.4	-	27	2969	c.2734G>C	c.(2734-2736)Gag>Cag	p.E912Q	DNMT1_ENST00000359526.4_Missense_Mutation_p.E928Q|DNMT1_ENST00000540357.1_Missense_Mutation_p.E912Q			P26358	DNMT1_HUMAN	DNA (cytosine-5-)-methyltransferase 1	912					chromatin modification|maintenance of DNA methylation|negative regulation of histone H3-K9 methylation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of gene expression|positive regulation of histone H3-K4 methylation|transcription, DNA-dependent	nucleus	DNA (cytosine-5-)-methyltransferase activity|DNA binding|transcription factor binding			breast(5)|endometrium(8)|kidney(5)|large_intestine(21)|lung(11)|ovary(2)|pancreas(1)|prostate(10)|skin(5)|stomach(1)|urinary_tract(1)	70			OV - Ovarian serous cystadenocarcinoma(20;1.59e-09)|Epithelial(33;2.86e-06)|all cancers(31;6.68e-06)		Azacitidine(DB00928)|Decitabine(DB01262)|Flucytosine(DB01099)|Ifosfamide(DB01181)|Procainamide(DB01035)	TCGAGCTGCTCCAGGACCCTG	0.562000													5	101					0	0	1	0	0
PIP4K2C	79837	broad.mit.edu	37	12	57985144	57985144	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr12:57985144C>G	ENST00000354947.5	+	1	88	c.72C>G	c.(70-72)ttC>ttG	p.F24L	PIP4K2C_ENST00000540759.2_Missense_Mutation_p.F24L|PIP4K2C_ENST00000422156.3_Missense_Mutation_p.F24L|PIP4K2C_ENST00000550465.1_Missense_Mutation_p.F24L			Q8TBX8	PI42C_HUMAN	phosphatidylinositol-5-phosphate 4-kinase, type II, gamma	24						cytoplasm|membrane	1-phosphatidylinositol-5-phosphate 4-kinase activity|ATP binding|identical protein binding			autonomic_ganglia(1)|breast(3)|central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(3)|lung(13)|pancreas(2)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	33	Melanoma(17;0.122)					GTTTCGGCTTCGCCTCCAAGA	0.652000													5	154					0	0	1	0	0
CDC42BPG	55561	broad.mit.edu	37	11	64602888	64602888	+	Silent	SNP	C	C	G			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr11:64602888C>G	ENST00000342711.5	-	16	1883	c.1884G>C	c.(1882-1884)ccG>ccC	p.P628P		NM_017525.2	NP_059995.2	Q6DT37	MRCKG_HUMAN	CDC42 binding protein kinase gamma (DMPK-like)	628				P -> R (in Ref. 1; AAT67172).	actin cytoskeleton reorganization|intracellular signal transduction	cell leading edge|centrosome	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			central_nervous_system(1)|lung(3)	4						CCTTACCACTCGGCCTGGGGA	0.682000													19	225					0	0	1	0	0
ZBTB40	9923	broad.mit.edu	37	1	22837748	22837748	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr1:22837748C>T	ENST00000404138.1	+	11	2421	c.1910C>T	c.(1909-1911)tCa>tTa	p.S637L	ZBTB40_ENST00000374651.4_Missense_Mutation_p.S525L|ZBTB40_ENST00000375647.4_Missense_Mutation_p.S637L	NM_001083621.1	NP_001077090.1	Q9NUA8	ZBT40_HUMAN	zinc finger and BTB domain containing 40	637					bone mineralization|regulation of transcription, DNA-dependent|response to DNA damage stimulus|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(4)|kidney(4)|large_intestine(6)|lung(8)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	26		Colorectal(325;3.46e-05)|Lung NSC(340;6.55e-05)|all_lung(284;9.87e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;2.86e-26)|Colorectal(126;8.55e-08)|COAD - Colon adenocarcinoma(152;4.1e-06)|GBM - Glioblastoma multiforme(114;1.39e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000712)|KIRC - Kidney renal clear cell carcinoma(1967;0.00374)|STAD - Stomach adenocarcinoma(196;0.00645)|READ - Rectum adenocarcinoma(331;0.0693)|Lung(427;0.216)		ATGGAAAAATCAGTCCCGGCC	0.502000													5	111					0	0	1	0	0
GBP5	115362	broad.mit.edu	37	1	89730405	89730405	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr1:89730405G>C	ENST00000343435.5	-	8	1649	c.1113C>G	c.(1111-1113)ttC>ttG	p.F371L	GBP5_ENST00000370459.3_Missense_Mutation_p.F371L|GBP5_ENST00000481145.1_5'UTR|RP4-620F22.2_ENST00000437128.1_RNA	NM_001134486.2|NM_052942.3	NP_001127958.1|NP_443174.1	Q96PP8	GBP5_HUMAN	guanylate binding protein 5	371						plasma membrane	GTP binding|GTPase activity			breast(1)|endometrium(1)|large_intestine(6)|lung(14)|ovary(1)|prostate(1)	24				all cancers(265;0.00784)|Epithelial(280;0.0286)		CTACATCCTTGAAAGAGTTTT	0.453000													4	88					0	0	1	0	0
PI4KA	5297	broad.mit.edu	37	22	21104247	21104247	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr22:21104247C>T	ENST00000255882.6	-	28	3275	c.3189G>A	c.(3187-3189)atG>atA	p.M1063I	PI4KA_ENST00000572273.1_Missense_Mutation_p.M1005I	NM_058004.3	NP_477352.3	P42356	PI4KA_HUMAN	phosphatidylinositol 4-kinase, catalytic, alpha	1005					phosphatidylinositol biosynthetic process|phosphatidylinositol-mediated signaling|synaptic transmission	Golgi-associated vesicle	1-phosphatidylinositol 4-kinase activity|ATP binding|protein binding			breast(3)|endometrium(8)|kidney(9)|large_intestine(19)|lung(29)|ovary(1)|pancreas(1)|prostate(3)|salivary_gland(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	79	all_cancers(11;7.59e-25)|all_epithelial(7;1.34e-22)|Melanoma(16;0.000465)|Ovarian(15;0.00167)|Colorectal(54;0.0332)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.000536)|Lung(15;0.0108)|Epithelial(17;0.196)			CCTGGAGGATCATCCCACAGC	0.527000													3	30					0	0	1	0	0
GABRB3	2562	broad.mit.edu	37	15	27184489	27184489	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr15:27184489G>A	ENST00000541819.2	-	1	197	c.95C>T	c.(94-96)tCa>tTa	p.S32L	GABRA5_ENST00000335625.5_Intron|GABRA5_ENST00000355395.5_Intron|GABRA5_ENST00000400081.3_Intron			P28472	GBRB3_HUMAN	gamma-aminobutyric acid (GABA) A receptor, beta 3	0			G -> R (in ECA5; the mutant protein is hyperglycosylated and has reduced mean current densities compared to wild-type).		synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			NS(2)|breast(1)|central_nervous_system(1)|cervix(4)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(11)|liver(1)|lung(41)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	68		all_cancers(20;1.89e-22)|all_lung(180;6.35e-15)|Breast(32;0.000279)|Colorectal(260;0.232)		all cancers(64;1.46e-07)|Epithelial(43;2.89e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0251)|COAD - Colon adenocarcinoma(236;0.235)|Lung(196;0.243)	Ethchlorvynol(DB00189)|Flurazepam(DB00690)|Lorazepam(DB00186)|Midazolam(DB00683)	CATCGCCAATGAAATGCCCCC	0.577000													7	93					0	0	1	0	0
SLC4A4	8671	broad.mit.edu	37	4	72215774	72215774	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr4:72215774C>T	ENST00000340595.3	+	2	599	c.403C>T	c.(403-405)Ctc>Ttc	p.L135F	SLC4A4_ENST00000264485.5_Missense_Mutation_p.L179F|SLC4A4_ENST00000514331.1_3'UTR|SLC4A4_ENST00000425175.1_Missense_Mutation_p.L179F|SLC4A4_ENST00000512686.1_Missense_Mutation_p.L135F|SLC4A4_ENST00000351898.6_Missense_Mutation_p.L179F	NM_003759.3	NP_003750.1	Q9Y6R1	S4A4_HUMAN	solute carrier family 4 (sodium bicarbonate cotransporter), member 4	179						basolateral plasma membrane|integral to plasma membrane	inorganic anion exchanger activity|protein binding|sodium:bicarbonate symporter activity			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(9)|liver(1)|lung(21)|ovary(3)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	58			Lung(101;0.0739)|LUSC - Lung squamous cell carcinoma(112;0.225)			GGCTTCTTCTCTCCCACAGTT	0.453000													21	155					0	0	1	0	0
ATM	472	broad.mit.edu	37	11	108235920	108235920	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr11:108235920G>A	ENST00000278616.4	+	62	9347	c.8962G>A	c.(8962-8964)Gac>Aac	p.D2988N	C11orf65_ENST00000526725.1_Intron|C11orf65_ENST00000525729.1_Intron|ATM_ENST00000525178.1_3'UTR|ATM_ENST00000452508.2_Missense_Mutation_p.D2988N	NM_000051.3	NP_000042.3	Q13315	ATM_HUMAN	ataxia telangiectasia mutated	2988					cell cycle arrest|cellular response to gamma radiation|DNA damage induced protein phosphorylation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|double-strand break repair via homologous recombination|G2/M transition DNA damage checkpoint|histone mRNA catabolic process|mitotic cell cycle spindle assembly checkpoint|negative regulation of B cell proliferation|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|pre-B cell allelic exclusion|protein autophosphorylation|reciprocal meiotic recombination|replicative senescence	cytoplasmic membrane-bounded vesicle|nucleoplasm	1-phosphatidylinositol-3-kinase activity|ATP binding|DNA binding|DNA-dependent protein kinase activity|identical protein binding|protein complex binding|protein dimerization activity|protein N-terminus binding			NS(4)|breast(23)|central_nervous_system(11)|endometrium(10)|haematopoietic_and_lymphoid_tissue(227)|kidney(19)|large_intestine(53)|liver(5)|lung(62)|ovary(6)|pancreas(4)|prostate(13)|skin(4)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	448		all_cancers(61;9.64e-12)|all_epithelial(67;9.97e-08)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		Epithelial(105;9.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.06e-05)|all cancers(92;0.000208)|Colorectal(284;0.116)|OV - Ovarian serous cystadenocarcinoma(223;0.147)		GAATGCAGATGACCAAGAATG	0.413000			"""D, Mis, N, F, S"""		T-PLL	"""leukemia, lymphoma, medulloblastoma, glioma"""		Genes defective in diseases associated with sensitivity to DNA damaging agents	Ataxia Telangiectasia	TSP Lung(14;0.12)			8	113					0	0	1	0	0
C18orf54	162681	broad.mit.edu	37	18	51887043	51887043	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr18:51887043C>T	ENST00000300091.5	+	2	433	c.101C>T	c.(100-102)tCt>tTt	p.S34F	C18orf54_ENST00000578138.1_Intron|C18orf54_ENST00000382911.4_Missense_Mutation_p.S34F	NM_173529.4	NP_775800.3	Q8IYD9	CR054_HUMAN	chromosome 18 open reading frame 54	34						extracellular region				breast(1)|central_nervous_system(1)|endometrium(3)|large_intestine(3)|lung(5)|ovary(1)|skin(1)	15				Colorectal(16;0.0206)|READ - Rectum adenocarcinoma(59;0.186)		TCCTCTAATTCTGATGGCTCG	0.408000													10	139					0	0	1	0	0
MARK2	2011	broad.mit.edu	37	11	63671514	63671514	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr11:63671514C>T	ENST00000402010.2	+	15	2150	c.1571C>T	c.(1570-1572)gCg>gTg	p.A524V	MARK2_ENST00000425897.2_Intron|MARK2_ENST00000377809.4_Missense_Mutation_p.A524V|MARK2_ENST00000350490.7_Intron|MARK2_ENST00000508192.1_Intron|MARK2_ENST00000377810.3_Intron|MARK2_ENST00000361128.5_Intron|MARK2_ENST00000513765.2_Missense_Mutation_p.A491V|MARK2_ENST00000509502.2_Missense_Mutation_p.A490V|MARK2_ENST00000408948.3_Intron|MARK2_ENST00000502399.3_Missense_Mutation_p.A523V|MARK2_ENST00000315032.8_Missense_Mutation_p.A524V|MARK2_ENST00000413835.2_Intron	NM_001039469.2	NP_001034558.2	Q7KZI7	MARK2_HUMAN	MAP/microtubule affinity-regulating kinase 2	524					cell differentiation|establishment or maintenance of epithelial cell apical/basal polarity|intracellular protein kinase cascade|multicellular organismal development|response to oxidative stress	plasma membrane	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(13)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	33						GCAGTCTCTGCGGCCCGGCCC	0.662000													3	14					0	0	1	0	0
GPC5	2262	broad.mit.edu	37	13	92380913	92380913	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr13:92380913G>A	ENST00000377067.3	+	4	1520	c.1148G>A	c.(1147-1149)aGa>aAa	p.R383K	GPC5_ENST00000483422.1_3'UTR	NM_004466.4	NP_004457.1	P78333	GPC5_HUMAN	glypican 5	383						anchored to membrane|extracellular space|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding			NS(1)|breast(4)|endometrium(6)|kidney(4)|large_intestine(7)|lung(34)|ovary(2)|pancreas(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	69	all_cancers(3;1.43e-07)|all_neural(89;0.0804)|Medulloblastoma(90;0.163)	Lung NSC(4;0.00454)				CTTGCCAACAGAAGAAAGTAA	0.363000													7	84					0	0	1	0	0
ATP8A2	51761	broad.mit.edu	37	13	26127956	26127956	+	Silent	SNP	C	C	T			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr13:26127956C>T	ENST00000381655.2	+	12	1225	c.1083C>T	c.(1081-1083)taC>taT	p.Y361Y	ATP8A2_ENST00000255283.8_Silent_p.Y321Y	NM_016529.4	NP_057613.4	Q9NTI2	AT8A2_HUMAN	ATPase, aminophospholipid transporter, class I, type 8A, member 2	321					ATP biosynthetic process|negative regulation of cell proliferation	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			breast(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(17)|lung(31)|ovary(4)|skin(3)|stomach(1)|urinary_tract(1)	72		Breast(139;0.0201)|Lung SC(185;0.0225)		all cancers(112;0.043)|OV - Ovarian serous cystadenocarcinoma(117;0.0748)|Epithelial(112;0.079)		ATTTTGGATACAACCTACTGA	0.383000													9	168					0	0	1	0	0
RNF213	57674	broad.mit.edu	37	17	78363062	78363062	+	Silent	SNP	C	C	G			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr17:78363062C>G	ENST00000582970.1	+	65	15233	c.15090C>G	c.(15088-15090)gtC>gtG	p.V5030V	RNF213_ENST00000427003.3_3'UTR|RNF213_ENST00000508628.2_Silent_p.V5079V|CTD-2047H16.4_ENST00000575034.1_RNA|CTD-2047H16.4_ENST00000573394.1_RNA|CTD-2047H16.4_ENST00000572151.1_RNA|RNF213_ENST00000336301.6_Silent_p.V3103V	NM_001256071.1	NP_001243000.1	Q9HCF4	ALO17_HUMAN	ring finger protein 213	0										NS(1)|breast(7)|central_nervous_system(1)|cervix(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(23)|lung(36)|ovary(11)|pancreas(2)|prostate(4)|skin(3)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	130	all_neural(118;0.0538)		BRCA - Breast invasive adenocarcinoma(99;0.0252)|OV - Ovarian serous cystadenocarcinoma(97;0.057)			TCGTAGAAGTCACTCTGGGGT	0.522000													6	99					0	0	1	0	0
OTUD7B	56957	broad.mit.edu	37	1	149916876	149916876	+	Nonsense_Mutation	SNP	G	G	C			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr1:149916876G>C	ENST00000369135.3	-	12	1706	c.1412C>G	c.(1411-1413)tCa>tGa	p.S471*		NM_020205.2	NP_064590.2	Q6GQQ9	OTU7B_HUMAN	OTU domain containing 7B	471					negative regulation of I-kappaB kinase/NF-kappaB cascade	cytoplasm|microtubule cytoskeleton|nucleus	cysteine-type peptidase activity|DNA binding|protein binding|zinc ion binding			breast(1)|endometrium(6)|kidney(2)|large_intestine(5)|lung(18)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	39	Breast(34;0.0009)|Ovarian(49;0.0265)|all_hematologic(923;0.0597)|Hepatocellular(266;0.161)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.171)|STAD - Stomach adenocarcinoma(528;0.247)			GCTGCCAACTGACTCCTTGTC	0.602000													6	103					0	0	1	0	0
C14orf39	317761	broad.mit.edu	37	14	60935201	60935201	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr14:60935201C>G	ENST00000321731.3	-	9	888	c.729G>C	c.(727-729)aaG>aaC	p.K243N		NM_174978.2	NP_777638.2	Q08AQ4	Q08AQ4_HUMAN	chromosome 14 open reading frame 39	243										breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(5)|lung(7)|ovary(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	30				OV - Ovarian serous cystadenocarcinoma(108;0.0448)		TATTTTTGTTCTTTTCTTCCA	0.289000													4	159					0	0	1	0	0
NINL	22981	broad.mit.edu	37	20	25472104	25472104	+	Silent	SNP	C	C	T			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr20:25472104C>T	ENST00000278886.6	-	11	1441	c.1368G>A	c.(1366-1368)gcG>gcA	p.A456A	NINL_ENST00000422516.1_Silent_p.A456A	NM_025176.4	NP_079452.3	Q9Y2I6	NINL_HUMAN	ninein-like	456					G2/M transition of mitotic cell cycle	cytosol|microtubule|microtubule organizing center	calcium ion binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(13)|lung(25)|ovary(2)|pancreas(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	57						GCTCTCGCTCCGCCTCCACCT	0.652000													6	61					0	0	1	0	0
EIF2AK3	9451	broad.mit.edu	37	2	88885506	88885506	+	Silent	SNP	G	G	A			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr2:88885506G>A	ENST00000303236.3	-	9	1804	c.1503C>T	c.(1501-1503)ctC>ctT	p.L501L	EIF2AK3_ENST00000419748.1_Silent_p.L350L	NM_004836.5	NP_004827.4	Q9NZJ5	E2AK3_HUMAN	eukaryotic translation initiation factor 2-alpha kinase 3	501					activation of caspase activity|bone mineralization|calcium-mediated signaling|chondrocyte development|endocrine pancreas development|endoplasmic reticulum organization|endoplasmic reticulum unfolded protein response|ER overload response|insulin secretion|insulin-like growth factor receptor signaling pathway|negative regulation of myelination|negative regulation of translational initiation in response to stress|protein autophosphorylation|protein homooligomerization	endoplasmic reticulum membrane|integral to membrane	ATP binding|eukaryotic translation initiation factor 2alpha kinase activity|identical protein binding			ovary(3)	3						GTGGGTTGTCGAGGAATCTGA	0.353000													13	149					0	0	1	0	0
ZNF382	84911	broad.mit.edu	37	19	37117312	37117312	+	Silent	SNP	C	C	G			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr19:37117312C>G	ENST00000435416.1	+	3	2005	c.510C>G	c.(508-510)ctC>ctG	p.L170L	ZNF382_ENST00000292928.2_Silent_p.L171L|ZNF382_ENST00000439428.1_Silent_p.L170L|ZNF382_ENST00000423582.1_Silent_p.L122L			Q96SR6	ZN382_HUMAN	zinc finger protein 382	171	Represses transcription (By similarity).				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(12)|lung(9)|prostate(2)|skin(2)|upper_aerodigestive_tract(4)	34	Esophageal squamous(110;0.198)		COAD - Colon adenocarcinoma(19;0.0454)|Colorectal(19;0.065)			AGAAATCACTCCTCAATACCA	0.373000													12	200					0	0	1	0	0
NMD3	51068	broad.mit.edu	37	3	160960409	160960409	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr3:160960409C>G	ENST00000460469.1	+	10	1440	c.985C>G	c.(985-987)Cgt>Ggt	p.R329G	NMD3_ENST00000351193.2_Missense_Mutation_p.R329G|NMD3_ENST00000472947.1_Missense_Mutation_p.R329G			Q96D46	NMD3_HUMAN	NMD3 ribosome export adaptor	329					protein transport	cytoplasm|nucleolus|nucleoplasm				cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(7)|lung(10)|ovary(1)|skin(1)|urinary_tract(2)	25			Lung(72;0.00111)|LUSC - Lung squamous cell carcinoma(72;0.00156)			AGATATAAAACGTGCTGCAGG	0.408000													14	146					0	0	1	0	0
ZNF217	7764	broad.mit.edu	37	20	52199008	52199008	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr20:52199008C>T	ENST00000371471.2	-	2	783	c.358G>A	c.(358-360)Gaa>Aaa	p.E120K	ZNF217_ENST00000302342.3_Missense_Mutation_p.E120K			O75362	ZN217_HUMAN	zinc finger protein 217	120					negative regulation of transcription, DNA-dependent	histone deacetylase complex	protein binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			NS(1)|breast(3)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(13)|lung(17)|ovary(1)|prostate(4)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	50	all_cancers(1;6.75e-17)|all_epithelial(1;1.76e-18)|Breast(2;3.83e-14)|Lung NSC(4;9.04e-07)|all_lung(4;2.5e-06)|Ovarian(1;0.0398)		BRCA - Breast invasive adenocarcinoma(1;9.88e-17)|Epithelial(1;1.56e-14)|all cancers(1;9.44e-13)|STAD - Stomach adenocarcinoma(23;0.0474)|Colorectal(105;0.198)			CAATTCTTTTCCTTGGGAGGT	0.453000													9	233					0	0	1	0	0
CCDC150	284992	broad.mit.edu	37	2	197534573	197534573	+	Nonsense_Mutation	SNP	C	C	G			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr2:197534573C>G	ENST00000472405.2	+	5	563	c.353C>G	c.(352-354)tCa>tGa	p.S118*	CCDC150_ENST00000272831.7_5'UTR|CCDC150_ENST00000423093.2_Intron|CCDC150_ENST00000389175.4_Silent_p.L303L			Q8NCX0	CC150_HUMAN	coiled-coil domain containing 150	221										breast(3)|endometrium(6)|kidney(1)|large_intestine(6)|lung(14)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	33						GAGATGACCTCATTTCCAAGT	0.333000													8	129					0	0	1	0	0
SCN2A	6326	broad.mit.edu	37	2	166210926	166210926	+	Silent	SNP	A	A	G			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr2:166210926A>G	ENST00000375437.2	+	17	3434	c.3144A>G	c.(3142-3144)aaA>aaG	p.K1048K	SCN2A_ENST00000375427.2_Silent_p.K1048K|SCN2A_ENST00000357398.3_Silent_p.K1048K|SCN2A_ENST00000283256.6_Silent_p.K1048K	NM_001040142.1	NP_001035232.1	Q99250	SCN2A_HUMAN	sodium channel, voltage-gated, type II, alpha subunit	1048					myelination	node of Ranvier|voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(1)|breast(7)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(27)|liver(2)|lung(49)|ovary(6)|pancreas(1)|prostate(2)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	118					Lamotrigine(DB00555)	TAAATAATAAAAAAGACAGCT	0.343000													7	77					0	0	1	0	0
MASTL	84930	broad.mit.edu	37	10	27459503	27459503	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr10:27459503G>A	ENST00000375946.4	+	8	2218	c.1615G>A	c.(1615-1617)Gac>Aac	p.D539N	MASTL_ENST00000375940.4_Missense_Mutation_p.D539N|MASTL_ENST00000477034.1_3'UTR|MASTL_ENST00000342386.6_Missense_Mutation_p.D539N	NM_001172303.1|NM_032844.3	NP_001165774.1|NP_116233.2	Q96GX5	GWL_HUMAN	microtubule associated serine/threonine kinase-like	539	Protein kinase.				cell division|G2/M transition of mitotic cell cycle|mitosis|negative regulation of protein phosphatase type 2A activity|regulation of cell cycle|response to DNA damage stimulus	centrosome|cleavage furrow|nucleus	ATP binding|protein phosphatase 2A binding|protein serine/threonine kinase activity			breast(3)|cervix(2)|endometrium(2)|large_intestine(7)|lung(9)|ovary(1)|pancreas(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29						ACTCGATGAAGACTGTGAAAA	0.313000													6	107					0	0	1	0	0
ZNF814	730051	broad.mit.edu	37	19	58385546	58385546	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr19:58385546G>T	ENST00000435989.2	-	3	1446	c.1212C>A	c.(1210-1212)gaC>gaA	p.D404E	ZNF814_ENST00000597342.1_Intron|ZNF814_ENST00000596604.1_Intron|ZNF814_ENST00000597832.1_Intron|ZNF814_ENST00000595295.1_Intron|ZNF814_ENST00000600634.1_Intron	NM_001144989.1	NP_001138461.1	B7Z6K7	ZN814_HUMAN	zinc finger protein 814	404					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding	p.D404E(10)		NS(1)|central_nervous_system(2)|endometrium(3)|kidney(9)|lung(2)|prostate(4)|skin(1)|urinary_tract(3)	25						AATGTTTTTTGTCAGTGTGAA	0.393000													4	25					0.014758	0.0148404	1	1	0
RIMS2	9699	broad.mit.edu	37	8	105260960	105260960	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr8:105260960G>A	ENST00000507740.1	+	19	3186	c.2950G>A	c.(2950-2952)Gat>Aat	p.D984N	RIMS2_ENST00000406091.3_Missense_Mutation_p.D1170N|RIMS2_ENST00000436393.2_Missense_Mutation_p.D1188N|RIMS2_ENST00000262231.10_Missense_Mutation_p.D1009N|RIMS2_ENST00000339750.2_Missense_Mutation_p.D106N	NM_014677.4	NP_055492.3	Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	1232					intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			NS(1)|breast(4)|central_nervous_system(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(22)|liver(1)|lung(68)|ovary(6)|pancreas(2)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(10)|urinary_tract(1)	144			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			CTTGGCCTCTGATAGCCAGTT	0.463000										HNSCC(12;0.0054)			6	123					0	0	1	0	0
ZBTB9	221504	broad.mit.edu	37	6	33424102	33424102	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr6:33424102C>T	ENST00000395064.2	+	2	1493	c.1225C>T	c.(1225-1227)Cgg>Tgg	p.R409W		NM_152735.3	NP_689948.1	Q96C00	ZBTB9_HUMAN	zinc finger and BTB domain containing 9	409					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|lung(6)|skin(1)|upper_aerodigestive_tract(2)	11						CTTCAGCCTTCGGCCTTTTGG	0.567000													7	41					0	0	1	0	0
ZNF429	353088	broad.mit.edu	37	19	21719223	21719223	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr19:21719223G>A	ENST00000358491.4	+	4	576	c.368G>A	c.(367-369)tGt>tAt	p.C123Y	ZNF429_ENST00000594022.1_3'UTR|ZNF429_ENST00000597078.1_Intron	NM_001001415.2	NP_001001415.2	Q86V71	ZN429_HUMAN	zinc finger protein 429	123					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(2)|kidney(2)|large_intestine(13)|lung(10)|ovary(2)|pancreas(1)|prostate(1)|soft_tissue(1)|upper_aerodigestive_tract(2)	34						GTAGGTGATTGTAAGCTATAC	0.328000													7	92					0	0	1	0	0
MTBP	27085	broad.mit.edu	37	8	121500404	121500404	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr8:121500404G>A	ENST00000305949.1	+	12	1216	c.1171G>A	c.(1171-1173)Gat>Aat	p.D391N		NM_022045.3	NP_071328.2	Q96DY7	MTBP_HUMAN	Mdm2, transformed 3T3 cell double minute 2, p53 binding protein (mouse) binding protein, 104kDa	391					cell cycle arrest					NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(10)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	30	Lung NSC(37;5.68e-08)|Ovarian(258;0.00769)|all_neural(195;0.0804)|Hepatocellular(40;0.161)		STAD - Stomach adenocarcinoma(47;0.00503)			TTTAGTTCCAGATGTTGAAGT	0.328000													9	77					0	0	1	0	0
MLH3	27030	broad.mit.edu	37	14	75513215	75513215	+	Silent	SNP	G	G	A			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr14:75513215G>A	ENST00000355774.2	-	2	3359	c.3144C>T	c.(3142-3144)ttC>ttT	p.F1048F	MLH3_ENST00000556740.1_Silent_p.F1048F|MLH3_ENST00000555671.1_5'UTR|MLH3_ENST00000556257.1_Silent_p.F1048F|MLH3_ENST00000544985.1_Silent_p.F43F|MLH3_ENST00000238662.7_Silent_p.F1048F|MLH3_ENST00000380968.2_5'UTR	NM_001040108.1	NP_001035197.1	Q9UHC1	MLH3_HUMAN	mutL homolog 3	1048					mismatch repair|reciprocal meiotic recombination	chiasma|MutLbeta complex|synaptonemal complex	ATP binding|ATPase activity|mismatched DNA binding|protein binding|satellite DNA binding			breast(5)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|liver(1)|lung(16)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	44				BRCA - Breast invasive adenocarcinoma(234;0.00688)		GGGCTACATCGAAATGCCGCT	0.433000								Mismatch excision repair (MMR)					11	127					0	0	1	0	0
CYP4Z1	199974	broad.mit.edu	37	1	47571830	47571830	+	Silent	SNP	G	G	A	rs151236717	byFrequency	TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr1:47571830G>A	ENST00000334194.3	+	9	1101	c.1098G>A	c.(1096-1098)acG>acA	p.T366T	CYP4A22-AS1_ENST00000444042.2_lincRNA	NM_178134.2	NP_835235.1	Q86W10	CP4Z1_HUMAN	cytochrome P450, family 4, subfamily Z, polypeptide 1	366						endoplasmic reticulum membrane|integral to membrane|microsome	aromatase activity|electron carrier activity|heme binding	p.T366T(1)		cervix(1)|large_intestine(4)|lung(4)|skin(1)|stomach(1)	11						CTTACACCACGATGTGCATCA	0.522000													6	150					0	0	1	0	0
HOXB3	3213	broad.mit.edu	37	17	46629701	46629701	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr17:46629701C>T	ENST00000470495.1	-	1	1583	c.136G>A	c.(136-138)Gac>Aac	p.D46N	HOXB-AS3_ENST00000465846.2_RNA|HOXB3_ENST00000498678.1_Missense_Mutation_p.D46N|HOXB3_ENST00000472863.1_5'UTR|HOXB3_ENST00000460160.1_Intron|HOXB3_ENST00000490677.1_Intron|HOXB3_ENST00000311626.4_Missense_Mutation_p.D46N|HOXB3_ENST00000489475.1_5'UTR|HOXB3_ENST00000485909.2_Intron|HOXB3_ENST00000476342.1_Missense_Mutation_p.D46N			P14651	HXB3_HUMAN	homeobox B3	46					angiogenesis	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(4)|kidney(2)|large_intestine(2)|lung(16)|prostate(4)|upper_aerodigestive_tract(1)	30						CGCTGGTAGTCGCCCTCCAGG	0.647000													4	51					0	0	1	0	0
MUC3A	4584	broad.mit.edu	37	7	100551290	100551290	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr7:100551290C>T	ENST00000319509.7	+	1	41	c.41C>T	c.(40-42)tCa>tTa	p.S14L						mucin 3A, cell surface associated											breast(3)|central_nervous_system(3)|endometrium(1)|kidney(1)|large_intestine(1)|lung(32)|prostate(3)	44						GCCATCACCTCACATTTTACT	0.517000													12	122					0	0	1	0	0
RPAP3	79657	broad.mit.edu	37	12	48075550	48075550	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr12:48075550G>A	ENST00000005386.3	-	10	1158	c.1043C>T	c.(1042-1044)tCa>tTa	p.S348L	RPAP3_ENST00000380650.4_Missense_Mutation_p.S348L|RPAP3_ENST00000432584.3_Missense_Mutation_p.S189L	NM_024604.2	NP_078880.2	Q9H6T3	RPAP3_HUMAN	RNA polymerase II associated protein 3	348							binding			endometrium(2)|large_intestine(4)|liver(1)|lung(6)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	16	Lung SC(27;0.192)					TTTAGAATATGAGCCATCTAA	0.363000													4	91					0	0	1	0	0
STK32A	202374	broad.mit.edu	37	5	146730662	146730662	+	Silent	SNP	G	G	A			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr5:146730662G>A	ENST00000397936.3	+	7	840	c.507G>A	c.(505-507)gcG>gcA	p.A169A	STK32A_ENST00000398523.3_Silent_p.A169A	NM_001112724.1	NP_001106195.1	Q8WU08	ST32A_HUMAN	serine/threonine kinase 32A	169	Protein kinase.						ATP binding|metal ion binding|protein serine/threonine kinase activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(7)|prostate(1)|skin(1)	13			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ACATTGCTGCGATGCTGCCCA	0.463000													5	89					0	0	1	0	0
TCF20	6942	broad.mit.edu	37	22	42607723	42607723	+	Missense_Mutation	SNP	G	G	C	rs144735319		TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr22:42607723G>C	ENST00000359486.3	-	1	3725	c.3589C>G	c.(3589-3591)Cca>Gca	p.P1197A	TCF20_ENST00000335626.4_Missense_Mutation_p.P1197A	NM_005650.1	NP_005641.1	Q9UGU0	TCF20_HUMAN	transcription factor 20 (AR1)	1197					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|transcription coactivator activity|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(7)|large_intestine(13)|lung(22)|ovary(5)|prostate(1)|skin(2)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(5)	66						CTTTTGGCTGGAGAAGTTTGC	0.498000													5	84					0	0	1	0	0
ARHGAP18	93663	broad.mit.edu	37	6	129929118	129929118	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr6:129929118C>T	ENST00000368149.2	-	9	1290	c.1202G>A	c.(1201-1203)aGc>aAc	p.S401N		NM_033515.2	NP_277050.2	Q8N392	RHG18_HUMAN	Rho GTPase activating protein 18	401	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|protein binding	p.S401N(1)		NS(2)|endometrium(1)|large_intestine(4)|lung(4)|ovary(2)|prostate(2)|skin(3)	18				OV - Ovarian serous cystadenocarcinoma(136;0.0621)|GBM - Glioblastoma multiforme(226;0.0638)|all cancers(137;0.074)		CTTCAGCAGGCTGGCGGCATC	0.458000													6	94					0	0	1	0	0
PCDHB15	56121	broad.mit.edu	37	5	140625549	140625549	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr5:140625549G>A	ENST00000231173.3	+	1	403	c.403G>A	c.(403-405)Gaa>Aaa	p.E135K		NM_018935.2	NP_061758.1	Q9Y5E8	PCDBF_HUMAN		135					homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			NS(1)|breast(3)|endometrium(8)|kidney(3)|large_intestine(14)|liver(1)|lung(18)|ovary(3)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)	61			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TGAGTTTCCTGAAAGAGAAAT	0.418000													7	157					0	0	1	0	0
KIAA1109	84162	broad.mit.edu	37	4	123267827	123267827	+	Silent	SNP	C	C	T			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr4:123267827C>T	ENST00000264501.4	+	75	13156	c.12783C>T	c.(12781-12783)ctC>ctT	p.L4261L	KIAA1109_ENST00000388738.3_Silent_p.L4261L			Q2LD37	K1109_HUMAN	KIAA1109	4261					regulation of cell growth|regulation of epithelial cell differentiation	integral to membrane|nucleus				breast(7)|central_nervous_system(1)|cervix(1)|endometrium(16)|kidney(6)|large_intestine(33)|liver(4)|lung(74)|ovary(9)|pancreas(1)|prostate(5)|skin(6)|upper_aerodigestive_tract(6)|urinary_tract(3)	172						TGCGCCGACTCAGTGAAATTC	0.353000													6	188					0	0	1	0	0
GRIN2C	2905	broad.mit.edu	37	17	72842377	72842377	+	Silent	SNP	G	G	A			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr17:72842377G>A	ENST00000293190.5	-	11	2324	c.2178C>T	c.(2176-2178)ttC>ttT	p.F726F	GRIN2C_ENST00000347612.4_Silent_p.F726F	NM_000835.3	NP_000826.2	Q14957	NMDE3_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 2C	726					glutamate signaling pathway	cell junction|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|N-methyl-D-aspartate selective glutamate receptor activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(2)|large_intestine(6)|lung(15)|ovary(2)|skin(2)|urinary_tract(1)	33	all_lung(278;0.172)|Lung NSC(278;0.207)				Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)	CATCATAGATGAAGGCATCCA	0.582000													5	79					0	0	1	0	0
CPAMD8	27151	broad.mit.edu	37	19	17057938	17057938	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr19:17057938C>G	ENST00000443236.1	-	21	2780	c.2749G>C	c.(2749-2751)Gag>Cag	p.E917Q		NM_015692.2	NP_056507.2	Q8IZJ3	CPMD8_HUMAN	C3 and PZP-like, alpha-2-macroglobulin domain containing 8	870						extracellular space|plasma membrane	serine-type endopeptidase inhibitor activity			breast(11)|central_nervous_system(3)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(17)|lung(14)|ovary(7)|pancreas(2)|prostate(4)|skin(5)	82						CAGATGGGCTCAGCCTCCCCG	0.597000													9	235					0	0	1	0	0
ZBTB6	10773	broad.mit.edu	37	9	125673418	125673418	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr9:125673418G>A	ENST00000373659.3	-	2	1022	c.934C>T	c.(934-936)Cat>Tat	p.H312Y		NM_006626.5	NP_006617.1	Q15916	ZBTB6_HUMAN	zinc finger and BTB domain containing 6	312					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(3)|endometrium(3)|kidney(1)|large_intestine(2)|lung(1)|skin(1)	11						TTTTCAACATGAAGAAAGCCT	0.418000													9	134					0	0	1	0	0
MYO1D	4642	broad.mit.edu	37	17	31082662	31082662	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr17:31082662G>C	ENST00000318217.5	-	11	1619	c.1315C>G	c.(1315-1317)Cag>Gag	p.Q439E	MYO1D_ENST00000579584.1_Missense_Mutation_p.Q439E|MYO1D_ENST00000394649.4_Missense_Mutation_p.Q351E|MYO1D_ENST00000584232.1_5'UTR	NM_015194.1	NP_056009.1	O94832	MYO1D_HUMAN	myosin ID	439	Myosin head-like.					myosin complex	actin binding|ATP binding|calmodulin binding			breast(1)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(8)|lung(14)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	39			BRCA - Breast invasive adenocarcinoma(9;0.0362)			ACAATGATCTGATTGTTGAAG	0.453000													4	45					0	0	1	0	0
DFFA	1676	broad.mit.edu	37	1	10523546	10523546	+	Silent	SNP	G	G	A			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr1:10523546G>A	ENST00000377038.3	-	4	640	c.573C>T	c.(571-573)ctC>ctT	p.L191L	DFFA_ENST00000377036.2_Silent_p.L191L	NM_004401.2	NP_004392.1	O00273	DFFA_HUMAN	DNA fragmentation factor, 45kDa, alpha polypeptide	191					DNA fragmentation involved in apoptotic nuclear change|intracellular signal transduction|negative regulation of apoptosis	cytosol|mitochondrion|nucleoplasm|plasma membrane	deoxyribonuclease activity|identical protein binding			large_intestine(3)|lung(2)	5	Ovarian(185;0.203)	all_lung(284;1.31e-05)|Lung NSC(185;2.19e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.25e-07)|COAD - Colon adenocarcinoma(227;7.25e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000296)|Kidney(185;0.00074)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(132;0.0167)|READ - Rectum adenocarcinoma(331;0.0487)		ACAGCTGCAGGAGCTGCTTGG	0.562000													7	162					0	0	1	0	0
ZNF468	90333	broad.mit.edu	37	19	53344689	53344689	+	Silent	SNP	G	G	A			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr19:53344689G>A	ENST00000595646.1	-	4	978	c.858C>T	c.(856-858)ctC>ctT	p.L286L	ZNF468_ENST00000396409.4_Silent_p.L233L|ZNF468_ENST00000243639.4_3'UTR|ZNF468_ENST00000390651.4_Silent_p.L233L|ZNF28_ENST00000594602.1_Intron			Q5VIY5	ZN468_HUMAN	zinc finger protein 468	286					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(5)|lung(5)|ovary(2)|skin(1)|stomach(3)|urinary_tract(1)	23				GBM - Glioblastoma multiforme(134;0.0358)		TGTGAATGAAGAGGGATGAAT	0.418000													14	202					0	0	1	0	0
DAXX	1616	broad.mit.edu	37	6	33286925	33286925	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr6:33286925G>A	ENST00000374542.5	-	7	2216	c.2012C>T	c.(2011-2013)tCc>tTc	p.S671F	DAXX_ENST00000414083.2_Missense_Mutation_p.S596F|DAXX_ENST00000266000.6_Missense_Mutation_p.S671F	NM_001141969.1|NM_001141970.1|NM_001350.4	NP_001135441.1|NP_001135442.1|NP_001341.1	Q9UER7	DAXX_HUMAN	death-domain associated protein	671	Interaction with SPOP.				activation of JUN kinase activity|androgen receptor signaling pathway|apoptosis|induction of apoptosis via death domain receptors|interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|regulation of protein ubiquitination|transcription, DNA-dependent	chromosome, centromeric region|cytosol|nucleolus|PML body	androgen receptor binding|heat shock protein binding|p53 binding|protein homodimerization activity|protein N-terminus binding|receptor signaling protein activity|transcription factor binding|ubiquitin protein ligase binding			breast(1)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(2)|lung(7)|ovary(3)|pancreas(18)|prostate(3)|skin(4)|upper_aerodigestive_tract(4)|urinary_tract(1)	55						AGCCAAGGGGGAAGGTGGGCT	0.542000			"""Mis, F, N"""		Pancreatic neuroendocrine tumors. Paediatric GBM								7	108					0	0	1	0	0
CENPV	201161	broad.mit.edu	37	17	16247996	16247996	+	Silent	SNP	G	G	A			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr17:16247996G>A	ENST00000476243.1	-	4	1276	c.147C>T	c.(145-147)ttC>ttT	p.F49F	PIGL_ENST00000581006.1_Intron|CENPV_ENST00000299736.4_Silent_p.F203F			Q7Z7K6	CENPV_HUMAN	centromere protein V	206					cell division|centromeric heterochromatin formation|mitosis|positive regulation of cytokinesis|regulation of chromosome organization	condensed chromosome kinetochore|cytoplasm|nucleus|spindle midzone	carbon-sulfur lyase activity			endometrium(1)|large_intestine(2)	3						TGTGAGTATTGAACGTGTAAG	0.388000													5	144					0	0	1	0	0
MYH7	4625	broad.mit.edu	37	14	23887583	23887583	+	Silent	SNP	C	C	T	rs144465613	byFrequency	TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr14:23887583C>T	ENST00000355349.3	-	30	4167	c.4005G>A	c.(4003-4005)tcG>tcA	p.S1335S		NM_000257.2	NP_000248.2	P12883	MYH7_HUMAN	myosin, heavy chain 7, cardiac muscle, beta	1335					adult heart development|muscle filament sliding|regulation of heart rate|ventricular cardiac muscle tissue morphogenesis	focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle	p.S1335S(3)		NS(3)|breast(4)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(19)|lung(57)|ovary(5)|prostate(9)|skin(5)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	137	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00725)		CATGCCGGGCCGACTGCAGTG	0.662000													5	66					0	0	1	0	0
ZNF366	167465	broad.mit.edu	37	5	71756606	71756606	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr5:71756606C>G	ENST00000318442.5	-	2	1208	c.718G>C	c.(718-720)Gac>Cac	p.D240H		NM_152625.1	NP_689838.1	Q8N895	ZN366_HUMAN	zinc finger protein 366	240					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(9)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	35		Lung NSC(167;0.0247)|Ovarian(174;0.0908)|Prostate(461;0.155)		OV - Ovarian serous cystadenocarcinoma(47;2.51e-53)		TAGTAGCTGTCATCGATCTGC	0.632000													7	185					0	0	1	0	0
DHX16	8449	broad.mit.edu	37	6	30640519	30640519	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr6:30640519C>T	ENST00000376442.3	-	1	295	c.100G>A	c.(100-102)Gca>Aca	p.A34T		NM_001164239.1|NM_003587.4	NP_001157711.1|NP_003578.2	O60231	DHX16_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 16	34					mRNA processing|RNA splicing	nucleus	ATP binding|ATP-dependent helicase activity|nucleic acid binding|RNA helicase activity			kidney(2)|ovary(2)	4						CAGCGCTGTGCGGTACCGATC	0.662000													4	63					0	0	1	0	0
EPG5	57724	broad.mit.edu	37	18	43467785	43467785	+	Silent	SNP	G	G	A			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr18:43467785G>A	ENST00000282041.5	-	29	5074	c.5040C>T	c.(5038-5040)gtC>gtT	p.V1680V	EPG5_ENST00000585906.1_5'UTR	NM_020964.2	NP_066015.2	Q9HCE0	EPG5_HUMAN	ectopic P-granules autophagy protein 5 homolog (C. elegans)	1680					autophagy					NS(1)|breast(9)|central_nervous_system(3)|cervix(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(22)|lung(35)|ovary(2)|pancreas(1)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	95						TCTCATCGCTGACGTAATCCA	0.458000													11	149					0	0	1	0	0
BAI2	576	broad.mit.edu	37	1	32210257	32210257	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr1:32210257G>A	ENST00000373658.3	-	5	1255	c.914C>T	c.(913-915)gCg>gTg	p.A305V	BAI2_ENST00000527361.1_Missense_Mutation_p.A305V|BAI2_ENST00000440175.2_Missense_Mutation_p.A2V|BAI2_ENST00000398538.1_Missense_Mutation_p.A293V|BAI2_ENST00000398542.1_Missense_Mutation_p.A293V|BAI2_ENST00000398547.1_Missense_Mutation_p.A293V|BAI2_ENST00000398556.3_Missense_Mutation_p.A308V|BAI2_ENST00000257070.4_Missense_Mutation_p.A305V|BAI2_ENST00000373655.2_Missense_Mutation_p.A305V	NM_001703.2	NP_001694.2	O60241	BAI2_HUMAN	brain-specific angiogenesis inhibitor 2	305					negative regulation of angiogenesis|neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(5)|central_nervous_system(2)|endometrium(1)|large_intestine(7)|liver(2)|lung(24)|ovary(7)|pancreas(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	55		Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0606)|all_neural(195;0.0837)|Breast(348;0.174)		STAD - Stomach adenocarcinoma(196;0.0557)		ACCTGTCTGCGCCATGTATAG	0.632000													4	26					0	0	1	0	0
KIAA1407	57577	broad.mit.edu	37	3	113697717	113697717	+	Silent	SNP	C	C	T			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr3:113697717C>T	ENST00000295878.3	-	15	2594	c.2448G>A	c.(2446-2448)caG>caA	p.Q816Q	KIAA1407_ENST00000545063.1_3'UTR	NM_020817.1	NP_065868.1	Q8NCU4	K1407_HUMAN	KIAA1407	816										endometrium(9)|large_intestine(7)|lung(19)|ovary(2)|pancreas(1)|prostate(1)|urinary_tract(1)	40						GTAGCCAGCTCTGGATGACTC	0.428000													14	202					0	0	1	0	0
KCNH5	27133	broad.mit.edu	37	14	63174643	63174643	+	Silent	SNP	C	C	T			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr14:63174643C>T	ENST00000322893.7	-	11	2818	c.2550G>A	c.(2548-2550)gaG>gaA	p.E850E	KCNH5_ENST00000420622.2_3'UTR	NM_139318.3	NP_647479.2	Q8NCM2	KCNH5_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 5	850					regulation of transcription, DNA-dependent	integral to membrane	calmodulin binding|two-component sensor activity|voltage-gated potassium channel activity			NS(1)|biliary_tract(1)|breast(3)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(22)|lung(33)|ovary(5)|prostate(2)|skin(17)|upper_aerodigestive_tract(4)|urinary_tract(2)	99				OV - Ovarian serous cystadenocarcinoma(108;0.00958)|BRCA - Breast invasive adenocarcinoma(234;0.168)		TCACACTGTTCTCTGAATCAC	0.453000													5	217					0	0	1	0	0
SDPR	8436	broad.mit.edu	37	2	192701254	192701254	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr2:192701254C>T	ENST00000304141.4	-	2	1002	c.673G>A	c.(673-675)Gaa>Aaa	p.E225K		NM_004657.5	NP_004648.1	O95810	SDPR_HUMAN	serum deprivation response	225						caveola|cytosol	phosphatidylserine binding|protein binding			NS(1)|central_nervous_system(1)|cervix(1)|large_intestine(6)|lung(9)|ovary(1)|pancreas(1)|urinary_tract(3)	23			OV - Ovarian serous cystadenocarcinoma(117;0.0647)		Phosphatidylserine(DB00144)	GCCCTACTTTCTTCCACCTTT	0.488000													10	201					0	0	1	0	0
ADM	133	broad.mit.edu	37	11	10327878	10327878	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr11:10327878G>A	ENST00000530439.1	+	2	808	c.44G>A	c.(43-45)aGc>aAc	p.S15N	ADM_ENST00000526492.1_Silent_p.Q93Q|ADM_ENST00000528655.1_Splice_Site|ADM_ENST00000534464.1_Splice_Site|ADM_ENST00000525063.1_Splice_Site|ADM_ENST00000278175.5_Splice_Site	NM_001124.1	NP_001115.1	P35318	ADML_HUMAN	adrenomedullin	83					blood circulation|cAMP biosynthetic process|female pregnancy|negative regulation of vasoconstriction|progesterone biosynthetic process|response to wounding	cytoplasm|extracellular space|soluble fraction	hormone activity			central_nervous_system(1)|large_intestine(2)|lung(2)|ovary(1)	6				all cancers(16;3.51e-65)|Epithelial(150;1.52e-62)|BRCA - Breast invasive adenocarcinoma(625;0.0257)		CCCGCCCGCAGCAGTCCGGAT	0.647000													7	35					0	0	1	0	0
TGM3	7053	broad.mit.edu	37	20	2321172	2321172	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr20:2321172C>T	ENST00000381458.5	+	13	2090	c.2027C>T	c.(2026-2028)tCc>tTc	p.S676F		NM_003245.3	NP_003236.3	Q08188	TGM3_HUMAN	transglutaminase 3	676					cell envelope organization|hair follicle morphogenesis|keratinization|peptide cross-linking|protein tetramerization	cytoplasm|extrinsic to internal side of plasma membrane	acyltransferase activity|calcium ion binding|GDP binding|GTP binding|GTPase activity|magnesium ion binding|protein-glutamine gamma-glutamyltransferase activity			breast(3)|cervix(1)|endometrium(1)|kidney(4)|large_intestine(11)|lung(10)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(2)	39					L-Glutamine(DB00130)	GCCGACTTCTCCTGCAACAAG	0.602000													6	93					0	0	1	0	0
PRRG1	5638	broad.mit.edu	37	X	37285197	37285197	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chrX:37285197G>A	ENST00000542554.1	+	4	387	c.115G>A	c.(115-117)Gaa>Aaa	p.E39K	PRRG1_ENST00000463135.1_Missense_Mutation_p.E39K|PRRG1_ENST00000543642.1_Missense_Mutation_p.E39K|PRRG1_ENST00000449135.2_Missense_Mutation_p.E39K|TM4SF2_ENST00000465127.1_Missense_Mutation_p.E39K|PRRG1_ENST00000378628.4_Missense_Mutation_p.E39K|PRRG1_ENST00000491253.1_Intron	NM_001173489.1	NP_001166960.1	O14668	TMG1_HUMAN	proline rich Gla (G-carboxyglutamic acid) 1	39	Gla.					extracellular region|integral to plasma membrane	calcium ion binding			breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(4)|ovary(3)|prostate(1)|upper_aerodigestive_tract(1)	15						TGAGTGCAAAGAAGAATTCTG	0.368000													7	40					0	0	1	0	0
UBA2	10054	broad.mit.edu	37	19	34929559	34929559	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr19:34929559G>A	ENST00000439527.2	+	6	679	c.181G>A	c.(181-183)Gag>Aag	p.E61K	UBA2_ENST00000246548.4_Missense_Mutation_p.E157K			Q9UBT2	SAE2_HUMAN	ubiquitin-like modifier activating enzyme 2	157					protein sumoylation	nucleus	ATP binding|enzyme activator activity|ligase activity|metal ion binding|protein heterodimerization activity|SUMO activating enzyme activity			breast(2)|endometrium(5)|kidney(1)|large_intestine(5)|lung(5)|ovary(1)|upper_aerodigestive_tract(1)	20	Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.211)			GGGTGTGACCGAGTGTTATGA	0.398000													15	206					0	0	1	0	0
GAPDH	2597	broad.mit.edu	37	12	6646520	6646520	+	Silent	SNP	C	C	T			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr12:6646520C>T	ENST00000229239.5	+	7	1155	c.489C>T	c.(487-489)gtC>gtT	p.V163V	GAPDH_ENST00000396858.1_Silent_p.V121V|GAPDH_ENST00000396861.1_Silent_p.V163V|GAPDH_ENST00000396856.1_Silent_p.V88V|GAPDH_ENST00000396859.1_Silent_p.V163V	NM_002046.4	NP_002037.2	P04406	G3P_HUMAN	glyceraldehyde-3-phosphate dehydrogenase	163					gluconeogenesis|glycolysis|neuron apoptosis|peptidyl-cysteine S-trans-nitrosylation|protein stabilization	cytosol|membrane|nucleus|perinuclear region of cytoplasm	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity|NAD binding|peptidyl-cysteine S-nitrosylase activity|protein binding			central_nervous_system(1)|cervix(1)|endometrium(1)|lung(4)	7					NADH(DB00157)	TGGCCAAGGTCATCCATGACA	0.577000													5	56					0	0	1	0	0
TMEM2	23670	broad.mit.edu	37	9	74360248	74360248	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr9:74360248C>G	ENST00000377044.4	-	4	1259	c.720G>C	c.(718-720)tgG>tgC	p.W240C	TMEM2_ENST00000377066.5_Missense_Mutation_p.W240C	NM_001135820.1|NM_013390.2	NP_001129292.1|NP_037522.1	Q9UHN6	TMEM2_HUMAN	transmembrane protein 2	240	G8.					integral to membrane				central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(15)|liver(1)|lung(19)|ovary(2)|prostate(5)|skin(1)|stomach(1)|urinary_tract(2)	56		all_epithelial(88;4.56e-14)|Myeloproliferative disorder(762;0.0255)		GBM - Glioblastoma multiforme(74;7.45e-21)|OV - Ovarian serous cystadenocarcinoma(323;1.02e-16)		CCAACAACGTCCACGATGCCT	0.507000													7	151					0	0	1	0	0
CDKL5	6792	broad.mit.edu	37	X	18626935	18626935	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chrX:18626935G>A	ENST00000379989.3	+	14	2234	c.1949G>A	c.(1948-1950)gGa>gAa	p.G650E	CDKL5_ENST00000379996.3_Missense_Mutation_p.G650E|CDKL5_ENST00000463994.1_3'UTR	NM_001037343.1	NP_001032420.1	O76039	CDKL5_HUMAN	cyclin-dependent kinase-like 5	650					neuron migration|positive regulation of axon extension|positive regulation of dendrite morphogenesis|positive regulation of Rac GTPase activity|protein autophosphorylation	dendrite cytoplasm|dendritic growth cone|nucleus	ATP binding|cyclin-dependent protein kinase activity|Rac GTPase binding			NS(2)|breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(12)|ovary(4)|skin(5)|stomach(1)	44	Hepatocellular(33;0.183)					TTCCAGCCTGGAGAACAGCTC	0.463000													5	35					0	0	1	0	0
DEPDC1B	55789	broad.mit.edu	37	5	59982922	59982922	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr5:59982922G>C	ENST00000265036.5	-	2	248	c.181C>G	c.(181-183)Caa>Gaa	p.Q61E	DEPDC1B_ENST00000545085.1_Missense_Mutation_p.Q34E|DEPDC1B_ENST00000453022.2_Missense_Mutation_p.Q61E	NM_018369.2	NP_060839.2	Q8WUY9	DEP1B_HUMAN	DEP domain containing 1B	61	DEP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity	p.Q61K(1)		endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(6)|ovary(1)|pancreas(2)|skin(2)	17		Lung NSC(810;0.000214)|Prostate(74;0.0147)|Breast(144;0.0991)|Ovarian(174;0.17)				CCGAAGTTTTGACTGCACCTC	0.488000													4	153					0	0	1	0	0
UNC45A	55898	broad.mit.edu	37	15	91478818	91478818	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr15:91478818C>G	ENST00000394275.2	+	5	886	c.51C>G	c.(49-51)ttC>ttG	p.F17L	UNC45A_ENST00000553671.2_3'UTR|UNC45A_ENST00000418476.2_Missense_Mutation_p.F32L	NM_001039675.1	NP_001034764.1	Q9H3U1	UN45A_HUMAN	unc-45 homolog A (C. elegans)	32					cell differentiation|muscle organ development	nucleus|perinuclear region of cytoplasm	protein binding			breast(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(7)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	25	Lung NSC(78;0.0771)|all_lung(78;0.137)		Lung(145;0.189)			ATGAGCTGTTCAAATGTGGAG	0.682000													7	104					0	0	1	0	0
TUBB6	84617	broad.mit.edu	37	18	12325401	12325401	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr18:12325401G>A	ENST00000317702.5	+	4	847	c.613G>A	c.(613-615)Gag>Aag	p.E205K	TUBB6_ENST00000591909.1_Intron|TUBB6_ENST00000591208.1_3'UTR|TUBB6_ENST00000590967.1_Intron			Q9BUF5	TBB6_HUMAN	tubulin, beta 6 class V	205					'de novo' posttranslational protein folding|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|structural molecule activity			endometrium(2)|kidney(1)|large_intestine(5)|lung(5)|prostate(1)	14				READ - Rectum adenocarcinoma(1;0.0649)		CATCGACAACGAGGCGCTCTA	0.602000													4	163					0	0	1	0	0
MAPKBP1	23005	broad.mit.edu	37	15	42113896	42113896	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr15:42113896G>A	ENST00000457542.2	+	24	3119	c.2833G>A	c.(2833-2835)Gaa>Aaa	p.E945K	MAPKBP1_ENST00000514566.1_Missense_Mutation_p.E945K|MAPKBP1_ENST00000260357.7_Missense_Mutation_p.E784K|MAPKBP1_ENST00000221214.6_Missense_Mutation_p.E828K|MAPKBP1_ENST00000456763.2_Missense_Mutation_p.E951K	NM_014994.2	NP_055809.2	O60336	MABP1_HUMAN	mitogen-activated protein kinase binding protein 1	951										breast(6)|central_nervous_system(5)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(11)|ovary(1)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	56		all_cancers(109;7.71e-14)|all_epithelial(112;5.15e-12)|Lung NSC(122;3.74e-08)|all_lung(180;1.81e-07)|Melanoma(134;0.0262)		OV - Ovarian serous cystadenocarcinoma(18;3.95e-17)|GBM - Glioblastoma multiforme(94;5.71e-07)|Lung(196;0.0436)|BRCA - Breast invasive adenocarcinoma(123;0.203)|LUSC - Lung squamous cell carcinoma(244;0.225)		TGCACCCATTGAAGATGGTAT	0.562000													8	78					0	0	1	0	0
TNFAIP8L3	388121	broad.mit.edu	37	15	51350317	51350317	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr15:51350317C>G	ENST00000327536.5	-	3	739	c.640G>C	c.(640-642)Gaa>Caa	p.E214Q	RP11-108K3.1_ENST00000559909.1_lincRNA	NM_207381.2	NP_997264.2	Q5GJ75	TP8L3_HUMAN	tumor necrosis factor, alpha-induced protein 8-like 3	214										endometrium(1)|kidney(1)|large_intestine(3)|lung(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	11				all cancers(107;0.000389)|GBM - Glioblastoma multiforme(94;0.00338)		AAGGTGTATTCCACCTCATAG	0.547000													8	112					0	0	1	0	0
ANKRD12	23253	broad.mit.edu	37	18	9254483	9254483	+	Silent	SNP	C	C	T			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr18:9254483C>T	ENST00000383440.2	+	8	1406	c.1149C>T	c.(1147-1149)ttC>ttT	p.F383F	ANKRD12_ENST00000400020.3_Silent_p.F383F|ANKRD12_ENST00000262126.3_Silent_p.F406F	NM_001083625.2	NP_001077094.1	Q6UB98	ANR12_HUMAN	ankyrin repeat domain 12	406						nucleus				NS(1)|breast(3)|central_nervous_system(2)|endometrium(8)|kidney(2)|large_intestine(20)|lung(18)|ovary(3)|pancreas(1)|prostate(4)|skin(1)|urinary_tract(2)	65						AGAAAGCCTTCTATCCTAAAT	0.308000													8	129					0	0	1	0	0
ARHGEF28	64283	broad.mit.edu	37	5	73091192	73091192	+	Nonsense_Mutation	SNP	G	G	T			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr5:73091192G>T	ENST00000545377.1	+	9	1176	c.1000G>T	c.(1000-1002)Gaa>Taa	p.E334*	ARHGEF28_ENST00000426542.2_Nonsense_Mutation_p.E334*|ARHGEF28_ENST00000437974.1_Nonsense_Mutation_p.E334*|ARHGEF28_ENST00000296794.6_Nonsense_Mutation_p.E334*|ARHGEF28_ENST00000287898.5_Nonsense_Mutation_p.E334*|ARHGEF28_ENST00000513042.2_Nonsense_Mutation_p.E334*	NM_001080479.2	NP_001073948.2			Rho guanine nucleotide exchange factor (GEF) 28																		CAATGAACATGAAGACCAGCA	0.388000													10	131					3.07112e-06	3.13498e-06	1	1	0
ELP3	55140	broad.mit.edu	37	8	27987062	27987062	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr8:27987062G>C	ENST00000256398.8	+	8	1038	c.661G>C	c.(661-663)Gaa>Caa	p.E221Q	ELP3_ENST00000380353.4_Missense_Mutation_p.E129Q|ELP3_ENST00000521015.1_Missense_Mutation_p.E207Q|ELP3_ENST00000537665.1_Missense_Mutation_p.E102Q|ELP3_ENST00000542181.1_Missense_Mutation_p.E92Q|ELP3_ENST00000524103.1_Missense_Mutation_p.E149Q	NM_018091.5	NP_060561.3	Q9H9T3	ELP3_HUMAN	elongator acetyltransferase complex subunit 3	221					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|DNA-directed RNA polymerase II, holoenzyme|nucleolus|transcription elongation factor complex	histone acetyltransferase activity|iron-sulfur cluster binding|metal ion binding|phosphorylase kinase regulator activity|protein binding			kidney(2)|large_intestine(3)|lung(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	10		Ovarian(32;0.0218)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0228)|KIRC - Kidney renal clear cell carcinoma(542;0.127)|Kidney(114;0.151)|Colorectal(74;0.183)		AATTACTATTGAAACCAGACC	0.398000													4	160					0	0	1	0	0
BAI3	577	broad.mit.edu	37	6	70048882	70048882	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr6:70048882C>T	ENST00000370598.1	+	25	4084	c.3263C>T	c.(3262-3264)tCa>tTa	p.S1088L	BAI3_ENST00000546190.1_Missense_Mutation_p.S52L|BAI3_ENST00000238918.8_Missense_Mutation_p.S294L	NM_001704.2	NP_001695.1	O60242	BAI3_HUMAN	brain-specific angiogenesis inhibitor 3	1088					negative regulation of angiogenesis|neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(2)|breast(4)|central_nervous_system(5)|endometrium(5)|kidney(2)|large_intestine(28)|liver(1)|lung(111)|ovary(10)|pancreas(4)|prostate(7)|skin(22)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	210		all_lung(197;0.212)				ACAGCTTTGTCAGCCACCACC	0.418000													8	200					0	0	1	0	0
SENP5	205564	broad.mit.edu	37	3	196650379	196650379	+	Nonsense_Mutation	SNP	C	C	G			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr3:196650379C>G	ENST00000323460.5	+	7	2228	c.1979C>G	c.(1978-1980)tCa>tGa	p.S660*	SENP5_ENST00000445299.2_Intron|SENP5_ENST00000419026.1_Nonsense_Mutation_p.S150*	NM_152699.4	NP_689912.2	Q96HI0	SENP5_HUMAN	SUMO1/sentrin specific peptidase 5	660	Protease.				cell cycle|cell division|proteolysis	nucleolus	cysteine-type peptidase activity			NS(1)|breast(2)|endometrium(2)|kidney(3)|large_intestine(9)|lung(14)|skin(1)	32	all_cancers(143;1.8e-08)|Ovarian(172;0.0634)|Breast(254;0.135)		Epithelial(36;3.14e-24)|all cancers(36;2.1e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.03e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.004)		CGAATTATTTCATTTTATGAT	0.333000													7	156					0	0	1	0	0
IMP4	92856	broad.mit.edu	37	2	131102966	131102966	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr2:131102966G>C	ENST00000259239.3	+	4	922	c.214G>C	c.(214-216)Gat>Cat	p.D72H	IMP4_ENST00000409935.1_Missense_Mutation_p.D72H	NM_033416.1	NP_219484.1	Q96G21	IMP4_HUMAN	IMP4, U3 small nucleolar ribonucleoprotein, homolog (yeast)	72					rRNA processing|translation	nucleolus|ribonucleoprotein complex	aminoacyl-tRNA ligase activity|ATP binding|protein binding			central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(7)|skin(1)|urinary_tract(1)	18	Colorectal(110;0.1)					CAGCCACGTGGATGATGAATA	0.547000													6	36					0	0	1	0	0
MAP3K10	4294	broad.mit.edu	37	19	40715015	40715015	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr19:40715015G>C	ENST00000253055.3	+	6	1729	c.1441G>C	c.(1441-1443)Gag>Cag	p.E481Q		NM_002446.3	NP_002437.2	Q02779	M3K10_HUMAN	mitogen-activated protein kinase kinase kinase 10	481					activation of JUN kinase activity|induction of apoptosis|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription, DNA-dependent|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of JNK cascade|protein autophosphorylation|smoothened signaling pathway	cytoplasm	ATP binding|bHLH transcription factor binding|JUN kinase kinase kinase activity|protein homodimerization activity|transcription corepressor activity			NS(1)|breast(1)|endometrium(4)|kidney(3)|large_intestine(4)|lung(5)|ovary(2)|pancreas(1)|prostate(1)|skin(2)	24						TGCAGGCTTTGAGCATAAGAT	0.502000													11	143					0	0	1	0	0
WDR5B	54554	broad.mit.edu	37	3	122134192	122134192	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr3:122134192C>T	ENST00000330689.4	-	1	690	c.184G>A	c.(184-186)Gat>Aat	p.D62N		NM_019069.3	NP_061942.2	Q86VZ2	WDR5B_HUMAN	WD repeat domain 5B	62										kidney(2)|large_intestine(4)|lung(2)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)	13				GBM - Glioblastoma multiforme(114;0.0704)		ATTAGCCTATCAGCAGAAGAA	0.403000													19	312					0	0	1	0	0
DNAH3	55567	broad.mit.edu	37	16	21147730	21147730	+	Silent	SNP	C	C	T			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr16:21147730C>T	ENST00000261383.3	-	6	800	c.801G>A	c.(799-801)ctG>ctA	p.L267L	DNAH3_ENST00000415178.1_Silent_p.L267L	NM_017539.1	NP_060009.1	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	267	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(3)|autonomic_ganglia(1)|breast(12)|central_nervous_system(3)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(42)|liver(2)|lung(57)|ovary(14)|pancreas(1)|prostate(7)|skin(11)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(6)	202				GBM - Glioblastoma multiforme(48;0.207)		AGGGACTCGTCAGCAGCGTGT	0.498000													7	156					0	0	1	0	0
ARHGEF17	9828	broad.mit.edu	37	11	73071382	73071382	+	Silent	SNP	G	G	A			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr11:73071382G>A	ENST00000263674.3	+	11	4574	c.4224G>A	c.(4222-4224)ctG>ctA	p.L1408L		NM_014786.3	NP_055601.2	Q96PE2	ARHGH_HUMAN	Rho guanine nucleotide exchange factor (GEF) 17	1408					actin cytoskeleton organization|apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(15)|ovary(2)|skin(2)	32						ACGATGCACTGCGGGACCTCT	0.652000													12	129					0	0	1	0	0
NEK7	140609	broad.mit.edu	37	1	198233296	198233296	+	Silent	SNP	C	C	T			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr1:198233296C>T	ENST00000367385.4	+	5	645	c.303C>T	c.(301-303)ttC>ttT	p.F101F	NEK7_ENST00000538004.1_Silent_p.F101F	NM_133494.2	NP_598001.1	Q8TDX7	NEK7_HUMAN	NIMA-related kinase 7	101	Protein kinase.					cytoplasm	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			endometrium(3)|kidney(2)|large_intestine(5)|lung(2)|ovary(1)|pancreas(1)|prostate(3)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)	21						ATGCATCATTCATTGAAGATA	0.313000													10	176					0	0	1	0	0
DNAH7	56171	broad.mit.edu	37	2	196664127	196664127	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr2:196664127C>G	ENST00000312428.6	-	55	10346	c.10246G>C	c.(10246-10248)Gat>Cat	p.D3416H		NM_018897.2	NP_061720.2	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	3416	AAA 6 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity	p.D3416N(1)		NS(4)|breast(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(28)|liver(3)|lung(100)|ovary(4)|prostate(5)|skin(26)|upper_aerodigestive_tract(2)|urinary_tract(3)	205						TTGGCTAAATCAAAGGGGGGT	0.438000													8	161					0	0	1	0	0
TMPRSS11A	339967	broad.mit.edu	37	4	68810254	68810254	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr4:68810254C>T	ENST00000508048.1	-	3	267	c.232G>A	c.(232-234)Gag>Aag	p.E78K	TMPRSS11A_ENST00000334830.7_Missense_Mutation_p.E79K|TMPRSS11A_ENST00000396188.2_Missense_Mutation_p.E79K|RP11-453E17.1_ENST00000500538.2_RNA			Q6ZMR5	TM11A_HUMAN	transmembrane protease, serine 11A	79	SEA.				cell cycle|proteolysis	extracellular region|integral to plasma membrane	serine-type endopeptidase activity			breast(1)|cervix(2)|kidney(1)|large_intestine(8)|lung(11)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)	29						TCGGTCGTCTCTCGTAAGTCC	0.338000													4	124					0	0	1	0	0
CSRNP2	81566	broad.mit.edu	37	12	51467818	51467818	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr12:51467818G>A	ENST00000228515.1	-	3	496	c.199C>T	c.(199-201)Cgc>Tgc	p.R67C		NM_030809.2	NP_110436.1	Q9H175	CSRN2_HUMAN	cysteine-serine-rich nuclear protein 2	67					apoptosis|positive regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(5)|urinary_tract(1)	14						TGGTCAAAGCGTACATTCTTC	0.493000													12	113					0	0	1	0	0
NFE2L1	4779	broad.mit.edu	37	17	46128846	46128846	+	Silent	SNP	C	C	T			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr17:46128846C>T	ENST00000362042.3	+	2	982	c.366C>T	c.(364-366)ctC>ctT	p.L122L	NFE2L1_ENST00000357480.5_Silent_p.L122L|NFE2L1_ENST00000585291.1_Silent_p.L122L|NFE2L1_ENST00000361665.3_Silent_p.L122L	NM_003204.2	NP_003195.1	Q14494	NF2L1_HUMAN	nuclear factor, erythroid 2-like 1	122					anatomical structure morphogenesis|heme biosynthetic process|inflammatory response|transcription from RNA polymerase II promoter	nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription cofactor activity			cervix(1)|endometrium(3)|kidney(9)|large_intestine(7)|lung(7)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	32						ACTCAGGCCTCGCCCTCGAGA	0.592000													4	87					0	0	1	0	0
GALR1	2587	broad.mit.edu	37	18	74963085	74963085	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr18:74963085C>T	ENST00000299727.3	+	1	581	c.581C>T	c.(580-582)cCt>cTt	p.P194L		NM_001480.3	NP_001471.2	P47211	GALR1_HUMAN	galanin receptor 1	194					digestion|negative regulation of adenylate cyclase activity	integral to membrane|plasma membrane	galanin receptor activity	p.P194N(2)		breast(2)|endometrium(1)|kidney(1)|large_intestine(3)|lung(13)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	24		Prostate(75;0.0865)|Esophageal squamous(42;0.129)|Melanoma(33;0.211)		OV - Ovarian serous cystadenocarcinoma(15;1.03e-06)|BRCA - Breast invasive adenocarcinoma(31;0.104)		TGGCCCGACCCTCGCCACAAG	0.662000													6	131					0	0	1	0	0
S1PR1	1901	broad.mit.edu	37	1	101704651	101704651	+	Silent	SNP	C	C	T			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr1:101704651C>T	ENST00000305352.6	+	2	486	c.111C>T	c.(109-111)atC>atT	p.I37I	S1PR1_ENST00000475821.1_3'UTR	NM_001400.4	NP_001391.2	P21453	S1PR1_HUMAN	sphingosine-1-phosphate receptor 1	37					cell adhesion	integral to membrane	lysosphingolipid and lysophosphatidic acid receptor activity			NS(1)|autonomic_ganglia(1)|breast(1)|large_intestine(7)|lung(23)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(4)	43						AGCTGAATATCAGCGCGGACA	0.502000											OREG0013620	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	79					0	0	1	0	0
PAPD4	167153	broad.mit.edu	37	5	78936984	78936984	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr5:78936984G>A	ENST00000453514.1	+	6	1330	c.637G>A	c.(637-639)Gat>Aat	p.D213N	PAPD4_ENST00000504233.1_Missense_Mutation_p.D213N|PAPD4_ENST00000296783.3_Missense_Mutation_p.D213N|PAPD4_ENST00000423041.2_Missense_Mutation_p.D213N|PAPD4_ENST00000428308.2_Missense_Mutation_p.D213N	NM_001114394.1	NP_001107866.1	Q6PIY7	GLD2_HUMAN	PAP associated domain containing 4	213					histone mRNA catabolic process|mRNA processing|RNA polyadenylation	cytoplasm	ATP binding|metal ion binding|polynucleotide adenylyltransferase activity			biliary_tract(1)|breast(2)|endometrium(4)|kidney(3)|large_intestine(9)|lung(4)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	29		Lung NSC(167;0.00293)|all_lung(232;0.00323)|Ovarian(174;0.0261)		OV - Ovarian serous cystadenocarcinoma(54;8.61e-47)|Epithelial(54;1.32e-41)|all cancers(79;2.45e-36)		CCGGAGCAGTGATGGTGATTT	0.323000													11	358					0	0	1	0	0
FOXP1	27086	broad.mit.edu	37	3	71027029	71027029	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr3:71027029C>T	ENST00000318789.4	-	15	1823	c.1298G>A	c.(1297-1299)gGa>gAa	p.G433E	FOXP1_ENST00000498215.1_Missense_Mutation_p.G433E|FOXP1_ENST00000491238.1_Missense_Mutation_p.G435E|FOXP1_ENST00000493089.1_Missense_Mutation_p.G433E|FOXP1_ENST00000468577.1_Missense_Mutation_p.G433E|FOXP1_ENST00000484350.1_Missense_Mutation_p.G357E|FOXP1_ENST00000475937.1_Missense_Mutation_p.G433E	NM_001244810.1|NM_001244813.1|NM_032682.5	NP_001231739.1|NP_001231742.1|NP_116071.2	Q9H334	FOXP1_HUMAN	forkhead box P1	433					cardiac muscle cell differentiation|embryo development|immunoglobulin V(D)J recombination|pattern specification process|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of immunoglobulin production|positive regulation of mesenchymal cell proliferation|pre-B cell differentiation|regulation of sequence-specific DNA binding transcription factor activity|skeletal muscle tissue development|smooth muscle tissue development	cytoplasm|transcription factor complex	chromatin binding|DNA bending activity|double-stranded DNA binding|promoter binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|zinc ion binding			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(7)|lung(8)|ovary(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	31		Lung NSC(201;4.62e-05)|Prostate(10;0.0181)|Hepatocellular(537;0.186)|Myeloproliferative disorder(1037;0.209)		BRCA - Breast invasive adenocarcinoma(55;1.17e-05)|Epithelial(33;1.39e-05)|LUSC - Lung squamous cell carcinoma(21;2.35e-05)|Lung(16;4.26e-05)		GCGGATGGGTCCCACCGTGTG	0.552000			T	PAX5	ALL								12	195					0	0	1	0	0
FGL1	2267	broad.mit.edu	37	8	17722252	17722252	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr8:17722252G>C	ENST00000398056.2	-	10	1603	c.788C>G	c.(787-789)tCt>tGt	p.S263C	FGL1_ENST00000381840.2_Missense_Mutation_p.S263C|FGL1_ENST00000522444.1_Missense_Mutation_p.S263C|FGL1_ENST00000381841.2_Missense_Mutation_p.S263C|FGL1_ENST00000518650.1_Missense_Mutation_p.S263C|FGL1_ENST00000427924.1_Missense_Mutation_p.S263C|FGL1_ENST00000398054.1_Missense_Mutation_p.S263C			Q08830	FGL1_HUMAN	fibrinogen-like 1	263	Fibrinogen C-terminal.				signal transduction	fibrinogen complex	receptor binding			NS(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(4)	13				Colorectal(111;0.0573)|COAD - Colon adenocarcinoma(73;0.215)		CAGGTTTGCAGAGTGACACCT	0.408000													8	38					0	0	1	0	0
APOA4	337	broad.mit.edu	37	11	116692523	116692523	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr11:116692523G>A	ENST00000357780.3	-	3	365	c.251C>T	c.(250-252)gCc>gTc	p.A84V		NM_000482.3	NP_000473.2			apolipoprotein A-IV											cervix(1)|endometrium(2)|lung(10)|prostate(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	20	all_hematologic(175;0.0487)	Breast(348;0.0126)|Medulloblastoma(222;0.0425)|all_hematologic(158;0.0564)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;8.54e-06)|Epithelial(105;1.62e-05)|all cancers(92;0.000165)|OV - Ovarian serous cystadenocarcinoma(223;0.148)		cagctcggtggcaaagggcac	0.602000													10	130					0	0	1	0	0
CSMD2	114784	broad.mit.edu	37	1	34066517	34066517	+	Silent	SNP	G	G	C			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr1:34066517G>C	ENST00000373381.4	-	44	6980	c.6804C>G	c.(6802-6804)ctC>ctG	p.L2268L	CSMD2_ENST00000373377.1_Silent_p.L367L|CSMD2_ENST00000373380.1_Silent_p.L1141L|CSMD2_ENST00000373388.2_Silent_p.L367L|CSMD2_ENST00000489419.1_5'UTR	NM_052896.3	NP_443128.2	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	2270	CUB 13.					integral to membrane|plasma membrane	protein binding			NS(5)|breast(5)|central_nervous_system(3)|cervix(2)|endometrium(20)|haematopoietic_and_lymphoid_tissue(4)|kidney(9)|large_intestine(43)|lung(114)|ovary(8)|pancreas(1)|prostate(6)|skin(20)|upper_aerodigestive_tract(5)|urinary_tract(1)	246		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				GGTGGAACTTGAGCAGGACCT	0.582000													9	172					0	0	1	0	0
NEK1	4750	broad.mit.edu	37	4	170400599	170400599	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr4:170400599C>T	ENST00000439128.2	-	22	2650	c.2010G>A	c.(2008-2010)atG>atA	p.M670I	NEK1_ENST00000511633.1_Missense_Mutation_p.M654I|NEK1_ENST00000512193.1_Missense_Mutation_p.M601I|NEK1_ENST00000510533.1_Missense_Mutation_p.M626I|NEK1_ENST00000507142.1_Missense_Mutation_p.M698I	NM_012224.2	NP_036356.1	Q96PY6	NEK1_HUMAN	NIMA-related kinase 1	670					cell division|cilium assembly|mitosis	nucleus|pericentriolar material	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(1)|breast(3)|endometrium(3)|kidney(2)|large_intestine(13)|lung(18)|ovary(2)|prostate(2)|stomach(1)	45		Prostate(90;0.00601)|Renal(120;0.0183)		GBM - Glioblastoma multiforme(119;0.0287)|KIRC - Kidney renal clear cell carcinoma(143;0.0325)|Kidney(143;0.0385)|LUSC - Lung squamous cell carcinoma(193;0.14)		TAACAGATCTCATCTGTTGCT	0.378000													9	110					0	0	1	0	0
DZIP1	22873	broad.mit.edu	37	13	96238340	96238340	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr13:96238340G>A	ENST00000347108.3	-	19	2701	c.2269C>T	c.(2269-2271)Cgc>Tgc	p.R757C	DZIP1_ENST00000361396.2_Missense_Mutation_p.R738C|DZIP1_ENST00000361156.3_Missense_Mutation_p.R738C|DZIP1_ENST00000376829.2_Missense_Mutation_p.R757C			Q86YF9	DZIP1_HUMAN	DAZ interacting zinc finger protein 1	757					germ cell development|multicellular organismal development|spermatogenesis	cytoplasm|nucleus	nucleic acid binding|protein binding|zinc ion binding			endometrium(1)|kidney(1)|large_intestine(20)|lung(11)|ovary(2)|pancreas(1)|skin(1)|stomach(1)	38	all_neural(89;0.0878)|Breast(111;0.148)|Medulloblastoma(90;0.163)		BRCA - Breast invasive adenocarcinoma(86;0.141)			ACATTTTTGCGATGTGGAAAC	0.318000													5	78					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179414070	179414070	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr2:179414070C>G	ENST00000589042.1	-	339	92507	c.92283G>C	c.(92281-92283)aaG>aaC	p.K30761N	TTN-AS1_ENST00000592750.1_RNA|RP11-65L3.2_ENST00000603415.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.K29120N|TTN-AS1_ENST00000590932.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000586831.1_RNA|TTN-AS1_ENST00000586707.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.K21696N|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000592600.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.K21888N|TTN-AS1_ENST00000456053.1_RNA|TTN-AS1_ENST00000438095.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.K21821N|TTN_ENST00000342992.6_Missense_Mutation_p.K28193N	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	29120	Fibronectin type-III 124.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTGTGCTTTTCTTTTCTCTTC	0.418000													8	103					0	0	1	0	0
SIGLEC8	27181	broad.mit.edu	37	19	51955714	51955714	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr19:51955714G>C	ENST00000321424.3	-	7	1485	c.1419C>G	c.(1417-1419)atC>atG	p.I473M	SIGLEC8_ENST00000430817.1_Missense_Mutation_p.I364M|SIGLEC8_ENST00000340550.5_Missense_Mutation_p.I380M	NM_014442.2	NP_055257.2	Q9NYZ4	SIGL8_HUMAN	sialic acid binding Ig-like lectin 8	473					cell adhesion	integral to membrane	sugar binding|transmembrane receptor activity			NS(1)|central_nervous_system(3)|endometrium(2)|kidney(4)|large_intestine(11)|liver(3)|lung(15)|ovary(2)|skin(4)|stomach(3)|urinary_tract(2)	50		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000627)|OV - Ovarian serous cystadenocarcinoma(262;0.00979)		TGTGGATCTTGATCTCCGAGT	0.517000													9	131					0	0	1	0	0
CD209	30835	broad.mit.edu	37	19	7812249	7812249	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr19:7812249C>T	ENST00000315599.7	-	2	71	c.49G>A	c.(49-51)Gag>Aag	p.E17K	CD209_ENST00000315591.8_Missense_Mutation_p.E17K|CD209_ENST00000601256.1_Missense_Mutation_p.E17K|CD209_ENST00000354397.6_Missense_Mutation_p.E17K|CD209_ENST00000394161.5_Missense_Mutation_p.E17K|CD209_ENST00000593821.1_Intron|CD209_ENST00000301357.8_Intron|CD209_ENST00000601951.1_Missense_Mutation_p.E17K|CD209_ENST00000394173.4_Missense_Mutation_p.E17K|CD209_ENST00000204801.8_Intron|CD209_ENST00000602261.1_Missense_Mutation_p.E17K|CD209_ENST00000593660.1_Missense_Mutation_p.E17K	NM_001144895.1|NM_001144897.1|NM_021155.3	NP_001138367.1|NP_001138369.1|NP_066978.1	Q9NNX6	CD209_HUMAN	CD209 molecule	17					cell-cell recognition|endocytosis|heterophilic cell-cell adhesion|innate immune response|intracellular signal transduction|intracellular virion transport|leukocyte cell-cell adhesion|peptide antigen transport|viral genome replication|virion attachment to host cell surface receptor	cytoplasm|extracellular region|integral to membrane|plasma membrane	mannose binding|metal ion binding|peptide antigen binding|receptor activity|virion binding			endometrium(7)|kidney(3)|large_intestine(6)|lung(10)|ovary(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	35						AGCTGTTCCTCCTCTGAATGG	0.572000													22	366					0	0	1	0	0
GTF2H5	404672	broad.mit.edu	37	6	158613079	158613079	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr6:158613079C>G	ENST00000607778.1	+	3	184	c.106C>G	c.(106-108)Caa>Gaa	p.Q36E		NM_207118.2	NP_997001.1	Q6ZYL4	TF2H5_HUMAN	general transcription factor IIH, polypeptide 5	36					nucleotide-excision repair|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding						Breast(66;0.00519)|Ovarian(120;0.123)|Prostate(117;0.178)		OV - Ovarian serous cystadenocarcinoma(65;5.98e-18)|BRCA - Breast invasive adenocarcinoma(81;2.83e-05)		GTTCATCATTCAAGACATTGA	0.423000								Nucleotide excision repair (NER)					11	111					0	0	1	0	0
ANLN	54443	broad.mit.edu	37	7	36455439	36455439	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr7:36455439G>C	ENST00000265748.2	+	8	1689	c.1468G>C	c.(1468-1470)Gaa>Caa	p.E490Q	ANLN_ENST00000495714.1_Intron|ANLN_ENST00000396068.2_Missense_Mutation_p.E490Q	NM_018685.2	NP_061155.2	Q9NQW6	ANLN_HUMAN	anillin, actin binding protein	490	Interaction with F-actin.				cytokinesis|mitosis|regulation of exit from mitosis|septin ring assembly	actomyosin contractile ring|nucleus	actin binding			breast(2)|endometrium(5)|kidney(5)|large_intestine(9)|lung(17)|ovary(2)|prostate(3)|skin(2)	45						TCCAGTAACAGAAAAGGTGAC	0.383000													4	172					0	0	1	0	0
ATF1	466	broad.mit.edu	37	12	51203320	51203320	+	Silent	SNP	C	C	T			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr12:51203320C>T	ENST00000262053.3	+	4	298	c.276C>T	c.(274-276)gtC>gtT	p.V92V	ATF1_ENST00000539132.1_Intron	NM_005171.4	NP_005162.1	P18846	ATF1_HUMAN	activating transcription factor 1	92					innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway				EWSR1/ATF1(347)|FUS/ATF1(4)	breast(1)|large_intestine(1)|ovary(2)	4						CTGCTGCTGTCACTTCTATGT	0.393000			T	"""EWSR1, FUS"""	"""malignant melanoma of soft parts , angiomatoid fibrous histiocytoma """								10	114					0	0	1	0	0
FIGN	55137	broad.mit.edu	37	2	164467396	164467396	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr2:164467396G>A	ENST00000333129.3	-	3	1260	c.946C>T	c.(946-948)Ctc>Ttc	p.L316F	FIGN_ENST00000409634.1_Intron	NM_018086.2	NP_060556.2	Q5HY92	FIGN_HUMAN	fidgetin	316						nuclear matrix	ATP binding|nucleoside-triphosphatase activity			breast(2)|endometrium(3)|kidney(2)|large_intestine(13)|lung(23)|ovary(1)|prostate(2)|skin(1)	47						TTCCTTTTGAGAGAACTTGCT	0.502000													5	104					0	0	1	0	0
PRX	57716	broad.mit.edu	37	19	40902682	40902682	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr19:40902682G>A	ENST00000324001.7	-	7	1847	c.1577C>T	c.(1576-1578)tCg>tTg	p.S526L	PRX_ENST00000291825.7_3'UTR	NM_181882.2	NP_870998.2	Q9BXM0	PRAX_HUMAN	periaxin	526	55 X 5 AA approximate tandem repeats of [LVMAG]-[PSREQC]-[EDKL]-[LIVMAP]- [AQKHRPE]; that may have a tripeptide spacer of [LV]-P-[KER].				axon ensheathment	cytoplasm|nucleus|plasma membrane	protein binding	p.S526L(1)		breast(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(7)|lung(12)|ovary(2)|prostate(3)|skin(1)|urinary_tract(9)	47			Lung(22;6.24e-05)|LUSC - Lung squamous cell carcinoma(20;0.000384)			TTTCATCTCCGACACTTTCAG	0.567000													9	200					0	0	1	0	0
HNRNPA1	3178	broad.mit.edu	37	12	54678090	54678090	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr12:54678090G>C	ENST00000546500.1	+	9	1571	c.956G>C	c.(955-957)aGa>aCa	p.R319T	HNRNPA1_ENST00000547276.1_Missense_Mutation_p.R266T|HNRNPA1_ENST00000340913.6_Missense_Mutation_p.R371T|HNRNPA1_ENST00000330752.8_Missense_Mutation_p.R306T|RP11-968A15.8_ENST00000553061.1_RNA			P09651	ROA1_HUMAN	heterogeneous nuclear ribonucleoprotein A1	371	Gly-rich.				interspecies interaction between organisms|mRNA transport|nuclear import	catalytic step 2 spliceosome|cytoplasm|heterogeneous nuclear ribonucleoprotein complex|nucleolus|nucleoplasm	nucleotide binding|protein binding|single-stranded DNA binding			endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(4)|lung(6)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	20						AGTGGCAGAAGATTTTAATTA	0.378000													5	69					0	0	1	0	0
FAT4	79633	broad.mit.edu	37	4	126408688	126408688	+	Silent	SNP	C	C	T			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr4:126408688C>T	ENST00000394329.3	+	16	13018	c.13005C>T	c.(13003-13005)ttC>ttT	p.F4335F	FAT4_ENST00000335110.5_Silent_p.F2576F	NM_024582.4	NP_078858.4	Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	4335	Laminin G-like 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						CTCAGGACTTCGGTGGCCTTG	0.418000													8	106					0	0	1	0	0
MBD6	114785	broad.mit.edu	37	12	57921393	57921393	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr12:57921393C>T	ENST00000355673.3	+	8	2542	c.2186C>T	c.(2185-2187)tCa>tTa	p.S729L	MBD6_ENST00000431731.2_Missense_Mutation_p.S729L	NM_052897.3	NP_443129.3	Q96DN6	MBD6_HUMAN	methyl-CpG binding domain protein 6	729	Pro-rich.					chromosome|nucleus	chromatin binding|DNA binding			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(8)|lung(8)|ovary(1)|urinary_tract(1)	31						CCCTCCAACTCAGGGAGACCC	0.617000													7	176					0	0	1	0	0
HECW1	23072	broad.mit.edu	37	7	43447198	43447198	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr7:43447198C>G	ENST00000395891.1	+	8	1274	c.669C>G	c.(667-669)ttC>ttG	p.F223L	HECW1_ENST00000453890.1_Missense_Mutation_p.F223L|HECW1_ENST00000471043.1_3'UTR	NM_015052.3	NP_055867.3	Q76N89	HECW1_HUMAN	HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1	223	C2.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	ubiquitin-protein ligase activity			NS(2)|breast(10)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(17)|lung(57)|ovary(8)|pancreas(2)|prostate(2)|skin(6)|urinary_tract(3)	125						GGATGTTTTTCAACCCAGACC	0.428000													3	50					0	0	1	0	0
IFNGR2	3460	broad.mit.edu	37	21	34799249	34799249	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr21:34799249C>G	ENST00000290219.6	+	4	1119	c.471C>G	c.(469-471)atC>atG	p.I157M	IFNGR2_ENST00000381995.1_Missense_Mutation_p.I176M|IFNGR2_ENST00000405436.1_Missense_Mutation_p.I78M	NM_005534.3	NP_005525.2	P38484	INGR2_HUMAN	interferon gamma receptor 2 (interferon gamma transducer 1)	157	Fibronectin type-III 2.				regulation of interferon-gamma-mediated signaling pathway|response to virus	endoplasmic reticulum|integral to plasma membrane	interferon-gamma receptor activity			NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(3)|urinary_tract(1)	13					Interferon gamma-1b(DB00033)	CCCTCATCATCAGGTTCTCCT	0.453000													15	278					0	0	1	0	0
SUFU	51684	broad.mit.edu	37	10	104359284	104359284	+	Silent	SNP	C	C	T			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr10:104359284C>T	ENST00000369902.3	+	8	1171	c.1005C>T	c.(1003-1005)ctC>ctT	p.L335L	SUFU_ENST00000423559.2_Silent_p.L335L|SUFU_ENST00000369899.2_Silent_p.L335L|SUFU_ENST00000471000.1_3'UTR	NM_016169.3	NP_057253.2	Q9UMX1	SUFU_HUMAN	suppressor of fused homolog (Drosophila)	335					negative regulation of transcription from RNA polymerase II promoter|proteolysis|skeletal system development	cytoplasm|nucleus	identical protein binding|protein binding|signal transducer activity|transcription corepressor activity|transcription factor binding			breast(2)|central_nervous_system(7)|endometrium(4)|kidney(1)|large_intestine(3)|lung(4)|prostate(1)|skin(2)	24		Colorectal(252;0.207)		Epithelial(162;1.36e-08)|all cancers(201;3.81e-07)|BRCA - Breast invasive adenocarcinoma(275;0.242)		AGAATGGCCTCGCCCACGACC	0.577000			"""D, F, S"""		medulloblastoma	medulloblastoma			Medulloblastoma, associated with Germline SUFU Mutation				4	66					0	0	1	0	0
NLRP12	91662	broad.mit.edu	37	19	54327417	54327417	+	Silent	SNP	G	G	A			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr19:54327417G>A	ENST00000324134.6	-	1	180	c.12C>T	c.(10-12)acC>acT	p.T4T	NLRP12_ENST00000351894.4_Silent_p.T4T|NLRP12_ENST00000391775.3_Silent_p.T4T|NLRP12_ENST00000354278.3_Silent_p.T4T|NLRP12_ENST00000391772.1_Silent_p.T4T|NLRP12_ENST00000345770.5_Silent_p.T4T|NLRP12_ENST00000391773.1_Silent_p.T4T|NLRP12_ENST00000535162.1_Silent_p.T4T	NM_001277126.1|NM_144687.2	NP_001264055.1|NP_653288.1	P59046	NAL12_HUMAN	NLR family, pyrin domain containing 12	4	DAPIN.				negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of interleukin-1 secretion|negative regulation of interleukin-6 biosynthetic process|negative regulation of protein autophosphorylation|negative regulation of Toll signaling pathway|positive regulation of inflammatory response|positive regulation of interleukin-1 beta secretion|regulation of interleukin-18 biosynthetic process|release of cytoplasmic sequestered NF-kappaB	cytoplasm	ATP binding|caspase activator activity|protein binding			NS(1)|breast(4)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|liver(1)|lung(36)|ovary(5)|pancreas(2)|skin(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	80	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.026)		CCCTGCCTGCGGTTCGTAGCA	0.602000													5	46					0	0	1	0	0
SMAD2	4087	broad.mit.edu	37	18	45368239	45368239	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr18:45368239G>A	ENST00000402690.2	-	11	1757	c.1363C>T	c.(1363-1365)Cag>Tag	p.Q455*	SMAD2_ENST00000262160.6_Nonsense_Mutation_p.Q455*|SMAD2_ENST00000356825.4_Nonsense_Mutation_p.Q425*|SMAD2_ENST00000586040.1_Nonsense_Mutation_p.Q425*	NM_001003652.3	NP_001003652.1	Q15796	SMAD2_HUMAN	SMAD family member 2	455	MH2.				anterior/posterior pattern formation|cell fate commitment|common-partner SMAD protein phosphorylation|intracellular signal transduction|mesoderm formation|negative regulation of transcription, DNA-dependent|palate development|paraxial mesoderm morphogenesis|positive regulation of epithelial to mesenchymal transition|positive regulation of transcription from RNA polymerase II promoter|primary miRNA processing|regulation of binding|regulation of transforming growth factor beta receptor signaling pathway|response to cholesterol|SMAD protein complex assembly|transforming growth factor beta receptor signaling pathway|zygotic specification of dorsal/ventral axis	activin responsive factor complex|cytosol	activating transcription factor binding|co-SMAD binding|double-stranded DNA binding|I-SMAD binding|R-SMAD binding|sequence-specific DNA binding transcription factor activity|transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity|type I transforming growth factor beta receptor binding|ubiquitin protein ligase binding			breast(1)|central_nervous_system(2)|endometrium(4)|kidney(3)|large_intestine(21)|liver(1)|lung(8)|prostate(2)|urinary_tract(1)	43						GATCCCATCTGAGTTAATACT	0.413000													6	72					0	0	1	0	0
FANCD2	2177	broad.mit.edu	37	3	10094157	10094157	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr3:10094157G>C	ENST00000287647.3	+	18	1725	c.1632G>C	c.(1630-1632)caG>caC	p.Q544H	FANCD2_ENST00000383807.1_Missense_Mutation_p.Q544H|FANCD2_ENST00000419585.1_Missense_Mutation_p.Q544H|FANCD2_ENST00000383806.1_Missense_Mutation_p.Q544H	NM_033084.3	NP_149075.2	Q9BXW9	FACD2_HUMAN	Fanconi anemia, complementation group D2	544					DNA repair|response to gamma radiation	nucleoplasm	protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(10)|ovary(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(3)	51				OV - Ovarian serous cystadenocarcinoma(96;0.148)		TTAGCAAACAGAATGAAGCCA	0.408000			"""D, Mis, N, F"""			"""AML, leukemia"""		Involved in tolerance or repair of DNA crosslinks	Fanconi Anemia				5	77					0	0	1	0	0
TCHH	7062	broad.mit.edu	37	1	152080837	152080837	+	Missense_Mutation	SNP	C	C	G	rs71585886		TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr1:152080837C>G	ENST00000368804.1	-	2	4855	c.4856G>C	c.(4855-4857)aGa>aCa	p.R1619T		NM_007113.2	NP_009044.2	Q07283	TRHY_HUMAN	trichohyalin	1619	23 X 26 AA approximate tandem repeats.				keratinization	cytoskeleton	calcium ion binding			NS(2)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(20)|kidney(9)|large_intestine(16)|lung(33)|ovary(3)|pancreas(1)|prostate(4)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(4)	105	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GCGGAATTTTCTGTCGCGCTC	0.582000													15	171					0	0	1	0	0
IGKV1-5	28299	broad.mit.edu	37	2	89246896	89246896	+	RNA	SNP	C	C	T			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr2:89246896C>T	ENST00000496168.1	-	0	454																											AGAGTGAATTCTGTCCCAGAT	0.478000													7	190					0	0	1	0	0
FRMPD1	22844	broad.mit.edu	37	9	37745714	37745714	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr9:37745714G>C	ENST00000539465.1	+	16	4278	c.3685G>C	c.(3685-3687)Gag>Cag	p.E1229Q	FRMPD1_ENST00000377765.3_Missense_Mutation_p.E1229Q|RP11-613M10.9_ENST00000540557.1_Intron			Q5SYB0	FRPD1_HUMAN	FERM and PDZ domain containing 1	1229						cytoskeleton|cytosol|plasma membrane				NS(3)|breast(2)|central_nervous_system(2)|endometrium(5)|kidney(4)|large_intestine(22)|lung(34)|ovary(5)|prostate(3)|skin(8)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	93				GBM - Glioblastoma multiforme(29;0.00655)		GATCAAGGCAGAGGCACCTAA	0.502000													5	103					0	0	1	0	0
NPM3	10360	broad.mit.edu	37	10	103542342	103542342	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr10:103542342C>T	ENST00000370110.5	-	3	239	c.217G>A	c.(217-219)Gag>Aag	p.E73K	NPM3_ENST00000474993.1_5'UTR	NM_006993.2	NP_008924.1	O75607	NPM3_HUMAN	nucleophosmin/nucleoplasmin 3	73							nucleic acid binding			large_intestine(3)|lung(1)|skin(1)	5		Colorectal(252;0.122)		Epithelial(162;3.94e-09)|all cancers(201;2.13e-07)		TTGGCTCCCTCGGTGAGGCAG	0.577000													5	54					0	0	1	0	0
RNF43	54894	broad.mit.edu	37	17	56492888	56492888	+	Silent	SNP	C	C	T			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr17:56492888C>T	ENST00000584437.1	-	1	2006	c.51G>A	c.(49-51)ctG>ctA	p.L17L	RNF43_ENST00000583753.1_Silent_p.L17L|BZRAP1-AS1_ENST00000583841.1_RNA|RNF43_ENST00000581868.1_Intron|RNF43_ENST00000577716.1_Silent_p.L17L|RNF43_ENST00000500597.2_Silent_p.L17L|RNF43_ENST00000407977.2_Silent_p.L17L			Q68DV7	RNF43_HUMAN	ring finger protein 43	17						endoplasmic reticulum membrane|integral to membrane|nuclear envelope	ligase activity|protein binding|zinc ion binding			NS(1)|biliary_tract(5)|breast(1)|central_nervous_system(1)|endometrium(10)|kidney(2)|large_intestine(14)|lung(9)|ovary(2)|pancreas(10)|prostate(1)|skin(4)	60	Medulloblastoma(34;0.127)|all_neural(34;0.237)					GGGTAGCCATCAGCAGCCAGG	0.562000													10	73					0	0	1	0	0
CSMD3	114788	broad.mit.edu	37	8	113395847	113395847	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr8:113395847C>T	ENST00000297405.5	-	37	6224	c.5980G>A	c.(5980-5982)Gac>Aac	p.D1994N	CSMD3_ENST00000455883.2_Missense_Mutation_p.D1890N|CSMD3_ENST00000352409.3_Missense_Mutation_p.D1924N|CSMD3_ENST00000343508.3_Missense_Mutation_p.D1954N	NM_198123.1	NP_937756.1	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3	1994	CUB 11.					integral to membrane|plasma membrane				breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						TCATAAAAGTCCAGAGAATCC	0.343000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			5	91					0	0	1	0	0
NUMA1	4926	broad.mit.edu	37	11	71724989	71724989	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr11:71724989G>C	ENST00000393695.3	-	15	3891	c.3560C>G	c.(3559-3561)tCg>tGg	p.S1187W	NUMA1_ENST00000351960.6_Intron|NUMA1_ENST00000358965.6_Missense_Mutation_p.S1187W	NM_006185.2	NP_006176.2	Q14980	NUMA1_HUMAN	nuclear mitotic apparatus protein 1	1187					G2/M transition of mitotic cell cycle|mitotic anaphase|nucleus organization	chromosome|cytosol|nucleoplasm|spindle microtubule|spindle pole	protein binding|structural molecule activity			central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(12)|lung(20)|ovary(5)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	65						CCGTTGGGCCGAGGCTAAGGC	0.652000			T	RARA	APL								4	66					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9011002	9011002	+	Silent	SNP	G	G	A			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr19:9011002G>A	ENST00000397910.4	-	37	39119	c.38916C>T	c.(38914-38916)ttC>ttT	p.F12972F		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	12974					cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TCCGATGGGTGAAACCTGCAT	0.542000													10	164					0	0	1	0	0
TCHH	7062	broad.mit.edu	37	1	152083910	152083910	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr1:152083910C>T	ENST00000368804.1	-	2	1782	c.1783G>A	c.(1783-1785)Gaa>Aaa	p.E595K		NM_007113.2	NP_009044.2	Q07283	TRHY_HUMAN	trichohyalin	595	9 X 28 AA approximate tandem repeats.				keratinization	cytoskeleton	calcium ion binding			NS(2)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(20)|kidney(9)|large_intestine(16)|lung(33)|ovary(3)|pancreas(1)|prostate(4)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(4)	105	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			AGCCTCTCTTCCTGCTCGCGC	0.682000													6	99					0	0	1	0	0
SYNE2	23224	broad.mit.edu	37	14	64691258	64691258	+	Missense_Mutation	SNP	G	G	A	rs148791608		TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr14:64691258G>A	ENST00000357395.3	+	114	20692	c.9548G>A	c.(9547-9549)cGa>cAa	p.R3183Q	SYNE2_ENST00000458046.2_Missense_Mutation_p.R469Q|SYNE2_ENST00000555002.1_Missense_Mutation_p.R3455Q|SYNE2_ENST00000554584.1_Missense_Mutation_p.R6714Q|SYNE2_ENST00000555022.1_Missense_Mutation_p.R676Q|SYNE2_ENST00000554805.1_Missense_Mutation_p.R581Q|ESR2_ENST00000542956.1_Intron|SYNE2_ENST00000394768.2_Missense_Mutation_p.R3183Q|SYNE2_ENST00000358025.3_Missense_Mutation_p.R6821Q|SYNE2_ENST00000441438.2_Missense_Mutation_p.R343Q|SYNE2_ENST00000344113.4_Missense_Mutation_p.R6798Q			Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	6798					centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			NS(5)|breast(17)|central_nervous_system(3)|cervix(8)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(21)|large_intestine(34)|lung(75)|ovary(10)|pancreas(2)|prostate(8)|skin(8)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(4)	224				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		CCAGCTCCCCGAGCAAAGGTA	0.542000													6	74					0	0	1	0	0
OR2A2	442361	broad.mit.edu	37	7	143806930	143806930	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr7:143806930G>A	ENST00000408979.2	+	1	324	c.255G>A	c.(253-255)atG>atA	p.M85I		NM_001005480.2	NP_001005480.2	Q6IF42	OR2A2_HUMAN	olfactory receptor, family 2, subfamily A, member 2	85					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(1)|large_intestine(2)|lung(13)|prostate(1)|skin(4)	22	Melanoma(164;0.0783)					CAAACCTAATGAACCAGAAAA	0.428000													7	220					0	0	1	0	0
KIAA2026	158358	broad.mit.edu	37	9	5922222	5922222	+	Silent	SNP	C	C	T			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr9:5922222C>T	ENST00000399933.3	-	8	3773	c.3774G>A	c.(3772-3774)caG>caA	p.Q1258Q	KIAA2026_ENST00000381461.2_Silent_p.Q1228Q	NM_001017969.2	NP_001017969.2	Q5HYC2	K2026_HUMAN	KIAA2026	1258										breast(6)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(11)|lung(15)|ovary(2)|prostate(2)|skin(1)	46		Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.00155)|Lung(218;0.124)		AATCAGCAGTCTGTTGTGCAA	0.448000													8	82					0	0	1	0	0
MED16	10025	broad.mit.edu	37	19	880111	880111	+	Silent	SNP	G	G	A			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr19:880111G>A	ENST00000312090.6	-	8	1329	c.1179C>T	c.(1177-1179)atC>atT	p.I393I	MED16_ENST00000589119.1_Silent_p.I393I|MED16_ENST00000606828.1_Intron|MED16_ENST00000395808.3_Silent_p.I393I|MED16_ENST00000269814.4_Silent_p.I393I|MED16_ENST00000325464.1_Silent_p.I393I			Q9Y2X0	MED16_HUMAN	mediator complex subunit 16	393					androgen receptor signaling pathway|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	receptor activity|thyroid hormone receptor binding|thyroid hormone receptor coactivator activity|vitamin D receptor binding			NS(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(12)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	21		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;6.59e-06)|all_lung(49;9.97e-06)|Breast(49;9.42e-05)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GCCGGTGCACGATGTGGACGC	0.721000													3	22					0	0	1	0	0
BZW1	9689	broad.mit.edu	37	2	201680219	201680219	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr2:201680219C>G	ENST00000409600.1	+	3	675	c.220C>G	c.(220-222)Ctg>Gtg	p.L74V	BZW1_ENST00000409226.1_Missense_Mutation_p.L78V|BZW1_ENST00000452790.2_Missense_Mutation_p.L106V	NM_001207067.1|NM_014670.3	NP_001193996.1|NP_055485.2	Q7L1Q6	BZW1_HUMAN	basic leucine zipper and W2 domains 1	74					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm	protein binding			breast(1)|kidney(2)|large_intestine(1)|lung(2)	6						CTTTGACATTCTGGTGGCTGG	0.398000													4	40					0	0	1	0	0
ATN1	1822	broad.mit.edu	37	12	7045484	7045484	+	Silent	SNP	C	C	T			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr12:7045484C>T	ENST00000356654.4	+	5	1291	c.1054C>T	c.(1054-1056)Ctg>Ttg	p.L352L	ATN1_ENST00000396684.2_Silent_p.L352L	NM_001007026.1	NP_001007027.1	P54259	ATN1_HUMAN	atrophin 1	352					cell death|central nervous system development	cytoplasm|nucleus	protein domain specific binding	p.L352V(1)		breast(5)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(15)|ovary(2)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	40						GGGCCCAACTCTGGCTCCTTC	0.612000													13	140					0	0	1	0	0
ATP13A5	344905	broad.mit.edu	37	3	192997178	192997178	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr3:192997178G>A	ENST00000342358.4	-	28	3409	c.3292C>T	c.(3292-3294)Caa>Taa	p.Q1098*	ATP13A5_ENST00000495496.1_5'UTR	NM_198505.2	NP_940907.2	Q4VNC0	AT135_HUMAN	ATPase type 13A5	1098					ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			NS(1)|autonomic_ganglia(2)|breast(1)|endometrium(6)|kidney(4)|large_intestine(15)|liver(2)|lung(26)|ovary(5)|prostate(1)|skin(10)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	76	all_cancers(143;1.08e-08)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(49;5.56e-18)|LUSC - Lung squamous cell carcinoma(58;6.08e-06)|Lung(62;6.49e-06)	GBM - Glioblastoma multiforme(46;0.000307)		TATATAACTTGAAAGTCAGAA	0.358000													4	93					0	0	1	0	0
FLG	2312	broad.mit.edu	37	1	152283664	152283664	+	Nonsense_Mutation	SNP	G	G	C			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr1:152283664G>C	ENST00000368799.1	-	3	3733	c.3698C>G	c.(3697-3699)tCa>tGa	p.S1233*	FLG-AS1_ENST00000420707.1_RNA|FLG-AS1_ENST00000593011.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	1233	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			ACGTGACCCTGAGTGCCTGGA	0.567000									Ichthyosis				5	458					0	0	1	0	0
CUL1	8454	broad.mit.edu	37	7	148457514	148457514	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr7:148457514G>A	ENST00000325222.4	+	7	994	c.715G>A	c.(715-717)Gac>Aac	p.D239N	CUL1_ENST00000409469.1_Missense_Mutation_p.D239N|CUL1_ENST00000602748.1_Missense_Mutation_p.D239N	NM_003592.2	NP_003583.2	Q13616	CUL1_HUMAN	cullin 1	239					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell cycle arrest|G1/S transition of mitotic cell cycle|induction of apoptosis by intracellular signals|interspecies interaction between organisms|negative regulation of cell proliferation|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein ubiquitination|S phase of mitotic cell cycle|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	cytosol|nucleoplasm|SCF ubiquitin ligase complex	ubiquitin protein ligase binding			breast(2)|central_nervous_system(2)|endometrium(1)|kidney(5)|large_intestine(10)|liver(2)|lung(10)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(4)	40	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00291)			ATTTTTGGCTGACACAGAGAG	0.358000													12	180					0	0	1	0	0
SOWAHB	345079	broad.mit.edu	37	4	77817787	77817787	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr4:77817787C>T	ENST00000334306.2	-	1	1215	c.1216G>A	c.(1216-1218)Gag>Aag	p.E406K		NM_001029870.1	NP_001025041.1	A6NEL2	ANR56_HUMAN	sosondowah ankyrin repeat domain family member B	406																	CTGCTCTCCTCACTGCCATCA	0.582000													4	114					0	0	1	0	0
HLA-A	3105	broad.mit.edu	37	6	29912276	29912276	+	Splice_Site	SNP	G	G	T	rs45540334		TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr6:29912276G>T	ENST00000396634.1	+	7	1236		c.e7-1		HLA-A_ENST00000376806.5_Splice_Site|HLA-A_ENST00000376809.5_Splice_Site|HLA-A_ENST00000376802.2_Intron			P30443	1A01_HUMAN	major histocompatibility complex, class I, A						antigen processing and presentation of peptide antigen via MHC class I|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|regulation of immune response|type I interferon-mediated signaling pathway	integral to plasma membrane|MHC class I protein complex	MHC class I receptor activity	p.?(1)		central_nervous_system(2)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(10)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	30						TCTTTTCCCAGAGCTGTCTTC	0.587000									Osteosarcoma, Familial Clustering of;Naso-/Oropharyngeal/Laryngeal Cancer, Familial Clustering of;Melanoma, Familial Clustering of;Lichen Sclerosis et Atrophicus, Familial Clustering of	Multiple Myeloma(9;0.094)			4	85					0.00909568	0.00916356	1	1	0
UBR2	23304	broad.mit.edu	37	6	42620295	42620295	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr6:42620295C>T	ENST00000372899.1	+	25	2939	c.2681C>T	c.(2680-2682)tCa>tTa	p.S894L	UBR2_ENST00000372901.1_Missense_Mutation_p.S894L|UBR2_ENST00000372883.3_Missense_Mutation_p.S398L	NM_015255.2	NP_056070.1	Q8IWV8	UBR2_HUMAN	ubiquitin protein ligase E3 component n-recognin 2	894					cellular response to leucine|chromatin silencing|histone H2A ubiquitination|negative regulation of TOR signaling cascade	nucleus|plasma membrane	leucine binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(10)|kidney(7)|large_intestine(14)|lung(22)|ovary(3)|pancreas(1)|skin(5)	64	Colorectal(47;0.196)		Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)|all cancers(41;0.004)|KIRC - Kidney renal clear cell carcinoma(15;0.02)|Kidney(15;0.0388)|OV - Ovarian serous cystadenocarcinoma(102;0.196)			ATTTTGCAGTCAGATGTCATG	0.448000													16	230					0	0	1	0	0
MTMR7	9108	broad.mit.edu	37	8	17169112	17169112	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr8:17169112G>A	ENST00000180173.5	-	9	1043	c.1009C>T	c.(1009-1011)Cac>Tac	p.H337Y	MTMR7_ENST00000521857.1_Missense_Mutation_p.H337Y|MTMR7_ENST00000398099.3_5'UTR	NM_004686.4	NP_004677.3	Q9Y216	MTMR7_HUMAN	myotubularin related protein 7	337	Myotubularin phosphatase.						protein tyrosine phosphatase activity			breast(1)|endometrium(5)|kidney(2)|large_intestine(5)|liver(1)|lung(8)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)	32				Colorectal(111;0.112)		TCAGAACAGTGAACAAGCACA	0.537000													30	380					0	0	1	0	0
ZNF215	7762	broad.mit.edu	37	11	6977082	6977082	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr11:6977082G>C	ENST00000278319.5	+	7	1462	c.874G>C	c.(874-876)Gag>Cag	p.E292Q	ZNF215_ENST00000529903.1_Intron|ZNF215_ENST00000527171.1_3'UTR|ZNF215_ENST00000414517.2_Missense_Mutation_p.E292Q	NM_013250.2	NP_037382.2	Q9UL58	ZN215_HUMAN	zinc finger protein 215	292					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(4)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(12)|ovary(1)|prostate(2)|skin(4)	32				Epithelial(150;6.33e-08)|BRCA - Breast invasive adenocarcinoma(625;0.134)		TTTCATTCCTGAGACAATTTA	0.363000													10	141					0	0	1	0	0
TPP2	7174	broad.mit.edu	37	13	103279445	103279445	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr13:103279445C>T	ENST00000376052.3	+	7	884	c.868C>T	c.(868-870)Caa>Taa	p.Q290*	TPP2_ENST00000376065.4_Nonsense_Mutation_p.Q290*			P29144	TPP2_HUMAN	tripeptidyl peptidase II	290					proteolysis	cytoplasm|nucleus	aminopeptidase activity|serine-type endopeptidase activity|tripeptidyl-peptidase activity			breast(2)|endometrium(5)|kidney(2)|large_intestine(12)|lung(21)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	52	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					TCCTGGTGCTCAAATTCTTTC	0.458000													5	111					0	0	1	0	0
ADORA3	140	broad.mit.edu	37	1	112042929	112042929	+	Silent	SNP	G	G	A			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr1:112042929G>A	ENST00000241356.4	-	2	1005	c.600C>T	c.(598-600)atC>atT	p.I200I	ADORA3_ENST00000369717.4_Intron|ADORA3_ENST00000369716.4_Intron	NM_000677.3	NP_000668.1	P33765	AA3R_HUMAN	adenosine A3 receptor	200					activation of adenylate cyclase activity|inflammatory response|regulation of heart contraction	integral to plasma membrane	adenosine receptor activity, G-protein coupled			NS(1)|breast(2)|endometrium(1)|large_intestine(2)|lung(3)|ovary(2)|skin(1)	12		all_cancers(81;1.63e-06)|all_epithelial(167;5.01e-06)|all_lung(203;8.02e-05)|Lung NSC(277;0.000156)		all cancers(265;0.0185)|Colorectal(144;0.0186)|Lung(183;0.0238)|COAD - Colon adenocarcinoma(174;0.0644)|Epithelial(280;0.0872)|LUSC - Lung squamous cell carcinoma(189;0.134)	Adenosine(DB00640)|Aminophylline(DB01223)	TGATGTAAAAGATGTCAAGAT	0.428000													6	111					0	0	1	0	0
SIRPA	140885	broad.mit.edu	37	20	1903191	1903191	+	Silent	SNP	C	C	T			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr20:1903191C>T	ENST00000358771.4	+	4	1139	c.987C>T	c.(985-987)ctC>ctT	p.L329L	SIRPA_ENST00000400068.3_Silent_p.L329L|SIRPA_ENST00000356025.3_Silent_p.L329L	NM_001040023.1	NP_001035112.1	P78324	SHPS1_HUMAN	signal-regulatory protein alpha	329	Ig-like C1-type 2.				blood coagulation|cell adhesion|cell junction assembly|leukocyte migration	integral to membrane|plasma membrane	SH3 domain binding			cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(13)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	21				Colorectal(46;0.018)|READ - Rectum adenocarcinoma(1;0.0556)		ATGTGAAGCTCACCTGCCAGG	0.572000													6	50					0	0	1	0	0
RAB3GAP1	22930	broad.mit.edu	37	2	135908057	135908057	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr2:135908057C>T	ENST00000264158.8	+	18	2085	c.2042C>T	c.(2041-2043)tCa>tTa	p.S681L	RAB3GAP1_ENST00000487003.1_3'UTR|RAB3GAP1_ENST00000539493.1_Missense_Mutation_p.S637L|ZRANB3_ENST00000412849.1_Intron|RAB3GAP1_ENST00000442034.1_Missense_Mutation_p.S681L	NM_012233.2	NP_036365.1	Q15042	RB3GP_HUMAN	RAB3 GTPase activating protein subunit 1 (catalytic)	681						centrosome|nucleus|soluble fraction	Rab GTPase activator activity|Rab GTPase binding			breast(1)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(5)|liver(1)|lung(10)|ovary(1)|prostate(1)|skin(3)|urinary_tract(1)	32				BRCA - Breast invasive adenocarcinoma(221;0.117)		TGTCTGCTCTCAGATATGGAG	0.468000													6	70					0	0	1	0	0
C2orf42	54980	broad.mit.edu	37	2	70406677	70406677	+	Silent	SNP	C	C	T			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr2:70406677C>T	ENST00000264434.2	-	4	1300	c.921G>A	c.(919-921)aaG>aaA	p.K307K	C2orf42_ENST00000420306.1_Silent_p.K307K	NM_017880.1	NP_060350.1	Q9NWW7	CB042_HUMAN	chromosome 2 open reading frame 42	307										endometrium(2)|large_intestine(4)|lung(4)|prostate(1)|urinary_tract(1)	12						ATACTTCATCCTTTCTCCTCT	0.393000													8	90					0	0	1	0	0
GLS2	27165	broad.mit.edu	37	12	56865935	56865935	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr12:56865935G>A	ENST00000311966.4	-	16	1834	c.1556C>T	c.(1555-1557)tCg>tTg	p.S519L		NM_013267.2	NP_037399.2	Q9UI32	GLSL_HUMAN	glutaminase 2 (liver, mitochondrial)	519					cellular amino acid biosynthetic process|glutamate secretion|glutamine metabolic process|neurotransmitter secretion	mitochondrial matrix	glutaminase activity|protein binding			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(4)|ovary(1)|stomach(1)|urinary_tract(1)	13					L-Glutamic Acid(DB00142)|L-Glutamine(DB00130)	AGCTGTGCGCGAGTCATAGTC	0.493000													26	150					0	0	1	0	0
SNX30	401548	broad.mit.edu	37	9	115593065	115593065	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr9:115593065G>A	ENST00000374232.3	+	4	684	c.520G>A	c.(520-522)Gag>Aag	p.E174K		NM_001012994.1	NP_001013012.1	Q5VWJ9	SNX30_HUMAN	sorting nexin family member 30	174	PX.				cell communication|protein transport	cytoplasm	phosphatidylinositol binding			large_intestine(1)|lung(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	8						AGAGTTTGTGGAGACCAGAAG	0.368000													8	120					0	0	1	0	0
DIP2B	57609	broad.mit.edu	37	12	51116998	51116998	+	Silent	SNP	C	C	T			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr12:51116998C>T	ENST00000301180.5	+	27	3214	c.3180C>T	c.(3178-3180)atC>atT	p.I1060I		NM_173602.2	NP_775873.2	Q9P265	DIP2B_HUMAN	DIP2 disco-interacting protein 2 homolog B (Drosophila)	1060						nucleus	catalytic activity|transcription factor binding			breast(1)|central_nervous_system(1)|endometrium(7)|kidney(4)|large_intestine(15)|lung(18)|ovary(4)|pancreas(1)|prostate(1)|skin(6)|urinary_tract(2)	60						TTGAGTTAATCGCCGCCTTCT	0.502000													18	138					0	0	1	0	0
TEK	7010	broad.mit.edu	37	9	27209227	27209227	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr9:27209227G>A	ENST00000380036.4	+	16	3126	c.2684G>A	c.(2683-2685)cGa>cAa	p.R895Q	TEK_ENST00000406359.4_Missense_Mutation_p.R852Q|TEK_ENST00000519097.1_Missense_Mutation_p.R747Q	NM_000459.3	NP_000450.2	Q02763	TIE2_HUMAN	TEK tyrosine kinase, endothelial	895	Protein kinase.				angiogenesis|blood coagulation|cell-cell signaling|leukocyte migration|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein kinase B signaling cascade|protein oligomerization|transmembrane receptor protein tyrosine kinase signaling pathway	apical plasma membrane|basolateral plasma membrane|cell surface|integral to plasma membrane|membrane raft|microvillus	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity			breast(3)|central_nervous_system(3)|kidney(1)|lung(2)|ovary(3)|skin(3)	15		all_neural(11;7.57e-10)|Myeloproliferative disorder(762;0.0255)		Lung(218;4.08e-05)|LUSC - Lung squamous cell carcinoma(38;0.00027)		TGTGAACATCGAGGTAAGATG	0.383000													4	42					0	0	1	0	0
TM4SF19	116211	broad.mit.edu	37	3	196054326	196054326	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr3:196054326G>C	ENST00000446879.1	-	2	261	c.136C>G	c.(136-138)Ctg>Gtg	p.L46V	TM4SF19_ENST00000454715.1_Missense_Mutation_p.L46V|TM4SF19_ENST00000273695.3_Missense_Mutation_p.L46V			Q96DZ7	T4S19_HUMAN	transmembrane 4 L six family member 19	46						integral to membrane				endometrium(2)|kidney(2)|large_intestine(3)|lung(5)	12	all_cancers(143;1.19e-08)|Ovarian(172;0.0634)|Breast(254;0.206)		Epithelial(36;3.94e-24)|all cancers(36;4.34e-22)|OV - Ovarian serous cystadenocarcinoma(49;8.53e-19)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00314)		CCCCTCAACAGGTAGGTGACA	0.607000													12	129					0	0	1	0	0
CCDC63	160762	broad.mit.edu	37	12	111296483	111296483	+	Silent	SNP	G	G	A			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr12:111296483G>A	ENST00000308208.5	+	4	515	c.273G>A	c.(271-273)aaG>aaA	p.K91K	CCDC63_ENST00000545036.1_Silent_p.K51K|CCDC63_ENST00000550317.1_3'UTR|CCDC63_ENST00000552694.1_Silent_p.K12K	NM_152591.1	NP_689804.1	Q8NA47	CCD63_HUMAN	coiled-coil domain containing 63	91										NS(2)|breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(15)|ovary(1)|pancreas(1)|prostate(2)|skin(7)|urinary_tract(1)	39						GGAGTGAGAAGAACTACATGG	0.478000													4	70					0	0	1	0	0
STAB2	55576	broad.mit.edu	37	12	104069774	104069774	+	Missense_Mutation	SNP	T	T	A			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr12:104069774T>A	ENST00000388887.2	+	24	2825	c.2621T>A	c.(2620-2622)cTa>cAa	p.L874Q		NM_017564.9	NP_060034.9	Q8WWQ8	STAB2_HUMAN	stabilin 2	874	EGF-like 8.				angiogenesis|cell adhesion|defense response to bacterium|receptor-mediated endocytosis	cytoplasm|external side of plasma membrane|integral to plasma membrane	Gram-negative bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			NS(4)|breast(7)|central_nervous_system(1)|cervix(1)|endometrium(15)|kidney(11)|large_intestine(26)|lung(77)|ovary(10)|pancreas(1)|prostate(5)|skin(14)|stomach(2)	174						TGCACAGGACTAACTCCAGGA	0.453000													4	60					0	0	1	0	0
SLC25A25	114789	broad.mit.edu	37	9	130854214	130854214	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr9:130854214G>A	ENST00000373066.5	+	1	472	c.65G>A	c.(64-66)aGa>aAa	p.R22K	RP11-379C10.4_ENST00000453870.1_RNA|SLC25A25_ENST00000432073.2_Missense_Mutation_p.R22K|SLC25A25_ENST00000373068.2_Intron|SLC25A25_ENST00000373069.5_Intron	NM_001265614.2	NP_001252543.1	Q6KCM7	SCMC2_HUMAN	solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25	0					transmembrane transport	integral to membrane|mitochondrial inner membrane	calcium ion binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(3)	10						CACGGCTCCAGAGAGGGGGAC	0.597000													9	169					0	0	1	0	0
SLC11A2	4891	broad.mit.edu	37	12	51402270	51402270	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr12:51402270G>C	ENST00000394904.3	-	3	308	c.259C>G	c.(259-261)Cct>Gct	p.P87A	SLC11A2_ENST00000545993.2_Missense_Mutation_p.P54A|SLC11A2_ENST00000541174.2_Missense_Mutation_p.P58A|SLC11A2_ENST00000547198.1_Missense_Mutation_p.P58A|SLC11A2_ENST00000549193.1_5'UTR|SLC11A2_ENST00000262051.7_Missense_Mutation_p.P58A|SLC11A2_ENST00000262052.5_Missense_Mutation_p.P58A|SLC11A2_ENST00000547688.1_Missense_Mutation_p.P87A|SLC11A2_ENST00000546743.1_5'UTR	NM_001174125.1	NP_001167596.1	P49281	NRAM2_HUMAN	solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2	58					activation of caspase activity|cellular iron ion homeostasis|cellular response to oxidative stress|detection of oxygen|ferrous iron import|multicellular organismal iron ion homeostasis|response to hypoxia|response to iron ion	apical plasma membrane|basal part of cell|cell surface|cytoplasmic vesicle|early endosome|late endosome|late endosome membrane|lysosomal membrane|lysosome|nucleus|paraferritin complex|perinuclear region of cytoplasm|plasma membrane|recycling endosome|trans-Golgi network	cadmium ion transmembrane transporter activity|cobalt ion transmembrane transporter activity|copper ion transmembrane transporter activity|ferrous iron transmembrane transporter activity|lead ion transmembrane transporter activity|manganese ion transmembrane transporter activity|nickel ion transmembrane transporter activity|protein binding|solute:hydrogen symporter activity|vanadium ion transmembrane transporter activity|zinc ion transmembrane transporter activity			breast(2)|cervix(1)|endometrium(3)|kidney(16)|large_intestine(4)|lung(9)|upper_aerodigestive_tract(1)	36						TCCTCCTCAGGAATGGAGATC	0.483000													14	178					0	0	1	0	0
HSPH1	10808	broad.mit.edu	37	13	31725112	31725112	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr13:31725112C>G	ENST00000320027.5	-	7	1224	c.880G>C	c.(880-882)Gat>Cat	p.D294H	HSPH1_ENST00000445273.2_Missense_Mutation_p.D296H|HSPH1_ENST00000380405.4_Missense_Mutation_p.D294H|HSPH1_ENST00000429785.2_Missense_Mutation_p.D113H|HSPH1_ENST00000380406.5_Missense_Mutation_p.D253H	NM_006644.2	NP_006635.2	Q92598	HS105_HUMAN	heat shock 105kDa/110kDa protein 1	294					positive regulation of MHC class I biosynthetic process|positive regulation of NK T cell activation|response to unfolded protein	cytoplasm|extracellular region	ATP binding			breast(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(4)|lung(7)|ovary(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	27		Lung SC(185;0.0257)		all cancers(112;0.00385)|Epithelial(112;0.0328)|OV - Ovarian serous cystadenocarcinoma(117;0.0375)|GBM - Glioblastoma multiforme(144;0.125)		ACATCTTTATCATTCATAAAG	0.388000													5	109					0	0	1	0	0
BAIAP2L1	55971	broad.mit.edu	37	7	97949564	97949564	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr7:97949564C>G	ENST00000005260.8	-	4	476	c.261G>C	c.(259-261)gaG>gaC	p.E87D	BAIAP2L1_ENST00000462558.1_5'UTR	NM_018842.4	NP_061330.2	Q9UHR4	BI2L1_HUMAN	BAI1-associated protein 2-like 1	87	IMD.				filopodium assembly|positive regulation of actin cytoskeleton reorganization|positive regulation of actin filament polymerization|response to bacterium|signal transduction	cell junction|cytoskeleton|cytosol|nucleus	actin binding|cytoskeletal adaptor activity|proline-rich region binding|SH3 domain binding			NS(1)|breast(1)|cervix(1)|endometrium(3)|large_intestine(7)|lung(8)|ovary(1)|prostate(1)	23	all_cancers(62;4.34e-10)|all_epithelial(64;5e-10)|Esophageal squamous(72;0.00918)|Lung NSC(181;0.0113)|all_lung(186;0.0126)		STAD - Stomach adenocarcinoma(171;0.215)			CATCAAGACTCTCGTTGAGTT	0.353000													4	68					0	0	1	0	0
IQUB	154865	broad.mit.edu	37	7	123152314	123152314	+	Silent	SNP	G	G	A			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr7:123152314G>A	ENST00000466202.1	-	2	657	c.81C>T	c.(79-81)gtC>gtT	p.V27V	IQUB_ENST00000434450.1_Silent_p.V27V|IQUB_ENST00000488987.1_Intron|IQUB_ENST00000324698.6_Silent_p.V27V			Q8NA54	IQUB_HUMAN	IQ motif and ubiquitin domain containing	27										breast(1)|endometrium(5)|kidney(3)|large_intestine(9)|lung(18)|ovary(3)|prostate(2)|stomach(3)|upper_aerodigestive_tract(1)	45						CTGGAATAGTGACAGTATCAA	0.373000													7	122					0	0	1	0	0
ZSCAN4	201516	broad.mit.edu	37	19	58187634	58187634	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr19:58187634G>A	ENST00000318203.5	+	3	818	c.121G>A	c.(121-123)Gag>Aag	p.E41K		NM_152677.2	NP_689890.1	Q8NAM6	ZSCA4_HUMAN	zinc finger and SCAN domain containing 4	41					telomere maintenance via telomere lengthening|viral reproduction	nuclear chromosome, telomeric region	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(3)|large_intestine(5)|liver(2)|lung(17)|ovary(1)|skin(1)|stomach(1)	30		Colorectal(82;0.000256)|all_neural(62;0.0577)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		AGGGATTTCTGAGTTCTCAAG	0.398000													8	107					0	0	1	0	0
PAMR1	25891	broad.mit.edu	37	11	35456291	35456291	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr11:35456291C>G	ENST00000378880.2	-	10	1840	c.1395G>C	c.(1393-1395)caG>caC	p.Q465H	PAMR1_ENST00000532848.1_Missense_Mutation_p.Q425H|PAMR1_ENST00000278360.3_Missense_Mutation_p.Q482H|PAMR1_ENST00000378878.3_Missense_Mutation_p.Q354H	NM_001001991.1	NP_001001991.1	Q6UXH9	PAMR1_HUMAN	peptidase domain containing associated with muscle regeneration 1	465	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(8)|ovary(3)|upper_aerodigestive_tract(1)	26						AGATGGCTGCCTGCCACGGCC	0.562000													9	99					0	0	1	0	0
CPS1	1373	broad.mit.edu	37	2	211421499	211421499	+	Silent	SNP	G	G	A			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr2:211421499G>A	ENST00000233072.5	+	1	238	c.42G>A	c.(40-42)ctG>ctA	p.L14L	CPS1_ENST00000430249.2_Silent_p.L20L	NM_001875.4	NP_001866.2	P31327	CPSM_HUMAN	carbamoyl-phosphate synthase 1, mitochondrial	14					carbamoyl phosphate biosynthetic process|citrulline biosynthetic process|glutamine metabolic process|glycogen catabolic process|nitric oxide metabolic process|positive regulation of vasodilation|response to lipopolysaccharide|triglyceride catabolic process|urea cycle	mitochondrial nucleoid	ATP binding|carbamoyl-phosphate synthase (ammonia) activity			breast(1)|central_nervous_system(4)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(17)|lung(85)|ovary(8)|pancreas(1)|prostate(6)|skin(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	142				Epithelial(149;0.00697)|Lung(261;0.0521)|LUSC - Lung squamous cell carcinoma(261;0.0544)|all cancers(144;0.0843)		TGAGGACACTGAAGACTGGTT	0.363000													9	125					0	0	1	0	0
DNAH11	8701	broad.mit.edu	37	7	21904161	21904161	+	Silent	SNP	G	G	A			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr7:21904161G>A	ENST00000328843.6	+	71	11434	c.11403G>A	c.(11401-11403)ttG>ttA	p.L3801L	DNAH11_ENST00000409508.3_Silent_p.L3794L			Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	3801					microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(1)|autonomic_ganglia(1)|breast(13)|central_nervous_system(3)|cervix(4)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(50)|lung(101)|ovary(10)|pancreas(4)|prostate(7)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	230						AGATTTTGTTGAGAAAGAAAG	0.378000									Kartagener syndrome				5	120					0	0	1	0	0
FCGR2A	2212	broad.mit.edu	37	1	161479635	161479635	+	Silent	SNP	C	C	T			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr1:161479635C>T	ENST00000271450.6	+	4	428	c.390C>T	c.(388-390)caC>caT	p.H130H	FCGR2A_ENST00000467525.1_3'UTR|FCGR2A_ENST00000367972.4_Silent_p.H129H	NM_001136219.1|NM_021642.3	NP_001129691.1|NP_067674.2	P12318	FCG2A_HUMAN	Fc fragment of IgG, low affinity IIa, receptor (CD32)	130	Ig-like C2-type 2.					integral to membrane|plasma membrane	IgG binding|receptor activity			autonomic_ganglia(1)|breast(2)|endometrium(2)|large_intestine(2)|lung(11)|ovary(1)	19	all_cancers(52;4.89e-16)|all_hematologic(112;0.0207)		BRCA - Breast invasive adenocarcinoma(70;0.00376)		Abciximab(DB00054)|Adalimumab(DB00051)|Alefacept(DB00092)|Alemtuzumab(DB00087)|Basiliximab(DB00074)|Bevacizumab(DB00112)|Cetuximab(DB00002)|Daclizumab(DB00111)|Efalizumab(DB00095)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Natalizumab(DB00108)|Palivizumab(DB00110)|Rituximab(DB00073)|Tositumomab(DB00081)|Trastuzumab(DB00072)	AGACCCCTCACCTGGAGTTCC	0.468000													11	130					0	0	1	0	0
GAPDH	2597	broad.mit.edu	37	12	6647075	6647075	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr12:6647075C>G	ENST00000229239.5	+	8	1517	c.851C>G	c.(850-852)tCt>tGt	p.S284C	GAPDH_ENST00000396858.1_Missense_Mutation_p.S242C|GAPDH_ENST00000396861.1_Missense_Mutation_p.S284C|GAPDH_ENST00000396856.1_Missense_Mutation_p.S209C|RP5-940J5.9_ENST00000602946.1_RNA|GAPDH_ENST00000396859.1_Missense_Mutation_p.S284C	NM_002046.4	NP_002037.2	P04406	G3P_HUMAN	glyceraldehyde-3-phosphate dehydrogenase	284					gluconeogenesis|glycolysis|neuron apoptosis|peptidyl-cysteine S-trans-nitrosylation|protein stabilization	cytosol|membrane|nucleus|perinuclear region of cytoplasm	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity|NAD binding|peptidyl-cysteine S-nitrosylase activity|protein binding			central_nervous_system(1)|cervix(1)|endometrium(1)|lung(4)	7					NADH(DB00157)	GTGGTCTCCTCTGACTTCAAC	0.567000											OREG0021628	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	5	60					0	0	1	0	0
VRK2	7444	broad.mit.edu	37	2	58386584	58386584	+	Nonsense_Mutation	SNP	C	C	G			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr2:58386584C>G	ENST00000435505.2	+	16	2028	c.1283C>G	c.(1282-1284)tCa>tGa	p.S428*	FANCL_ENST00000402135.3_3'UTR|FANCL_ENST00000403295.3_3'UTR|VRK2_ENST00000440705.2_Nonsense_Mutation_p.S405*|FANCL_ENST00000233741.4_3'UTR|VRK2_ENST00000340157.4_Nonsense_Mutation_p.S428*|VRK2_ENST00000417641.2_3'UTR|VRK2_ENST00000412104.2_3'UTR			Q86Y07	VRK2_HUMAN	vaccinia related kinase 2	428						integral to membrane	ATP binding|protein binding|protein serine/threonine kinase activity			endometrium(4)|kidney(2)|large_intestine(5)|lung(12)|ovary(1)	24						TTCCCAAACTCATTTTATGAG	0.378000													7	86					0	0	1	0	0
NOTCH4	4855	broad.mit.edu	37	6	32185850	32185850	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr6:32185850C>G	ENST00000375023.3	-	9	1684	c.1546G>C	c.(1546-1548)Gag>Cag	p.E516Q		NM_004557.3	NP_004548.3	Q99466	NOTC4_HUMAN	notch 4	516	EGF-like 13; calcium-binding (Potential).				cell fate determination|embryo development|hemopoiesis|mammary gland development|negative regulation of endothelial cell differentiation|Notch receptor processing|Notch signaling pathway|patterning of blood vessels|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|protein heterodimerization activity|receptor activity			NS(1)|autonomic_ganglia(1)|breast(4)|central_nervous_system(4)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(47)|ovary(5)|prostate(4)|skin(10)|upper_aerodigestive_tract(1)|urinary_tract(1)	100						GAGGCACACTCGTTGGTCTCC	0.607000													3	17					0	0	1	0	0
BRAP	8315	broad.mit.edu	37	12	112110555	112110555	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr12:112110555C>T	ENST00000419234.4	-	5	850	c.657G>A	c.(655-657)atG>atA	p.M219I	BRAP_ENST00000327551.6_Missense_Mutation_p.M189I|BRAP_ENST00000539060.1_Intron	NM_006768.3	NP_006759.3	Q7Z569	BRAP_HUMAN	BRCA1 associated protein	219					MAPKKK cascade|negative regulation of signal transduction|Ras protein signal transduction	cytoplasm|ubiquitin ligase complex	identical protein binding|nuclear localization sequence binding|nucleotide binding|ubiquitin-protein ligase activity|zinc ion binding			cervix(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(5)|prostate(2)|skin(1)|stomach(1)|urinary_tract(1)	20						CATTGCATGTCATATAAAAAC	0.393000													6	106					0	0	1	0	0
PCDH11Y	83259	broad.mit.edu	37	Y	5605718	5605718	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chrY:5605718C>T	ENST00000215473.6	+	6	3758	c.3758C>T	c.(3757-3759)tCt>tTt	p.S1253F				Q9BZA8	PC11Y_HUMAN	protocadherin 11 Y-linked	1253					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			autonomic_ganglia(1)|kidney(2)|large_intestine(7)|lung(14)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	27						CACAGCTCTTCTCTGCCACAG	0.547000													4	108					0	0	1	0	0
ANXA5	308	broad.mit.edu	37	4	122605900	122605900	+	Silent	SNP	G	G	A			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr4:122605900G>A	ENST00000296511.5	-	4	406	c.121C>T	c.(121-123)Ctg>Ttg	p.L41L	ANXA5_ENST00000501272.2_Intron|ANXA5_ENST00000515017.1_Intron|ANXA5_ENST00000509016.1_5'UTR	NM_001154.3	NP_001145.1	P08758	ANXA5_HUMAN	annexin A5	41					anti-apoptosis|blood coagulation|negative regulation of coagulation|signal transduction	cytoplasm	calcium ion binding|calcium-dependent phospholipid binding|phospholipase inhibitor activity			NS(1)|breast(1)|endometrium(2)|large_intestine(1)|lung(9)|ovary(1)	15						GATGTCAACAGAGTCAGGATG	0.468000													8	137					0	0	1	0	0
CD38	952	broad.mit.edu	37	4	15850161	15850161	+	Splice_Site	SNP	G	G	C			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr4:15850161G>C	ENST00000226279.2	+	8	976		c.e8-1			NM_001775.2	NP_001766.2	P28907	CD38_HUMAN	CD38 molecule						B cell receptor signaling pathway|induction of apoptosis by extracellular signals|negative regulation of apoptosis|negative regulation of transcription, DNA-dependent|positive regulation of B cell proliferation|positive regulation of transcription, DNA-dependent|response to drug	integral to membrane|plasma membrane	binding|NAD+ nucleosidase activity|receptor activity			endometrium(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(2)|prostate(1)|stomach(1)	14						TCTTGTCATAGACCTGACAAG	0.448000													7	62					0	0	1	0	0
AKAP6	9472	broad.mit.edu	37	14	33014457	33014457	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr14:33014457G>A	ENST00000280979.4	+	4	768	c.598G>A	c.(598-600)Gaa>Aaa	p.E200K	AKAP6_ENST00000557354.1_Missense_Mutation_p.E200K|AKAP6_ENST00000557272.1_Missense_Mutation_p.E200K	NM_004274.4	NP_004265.3	Q13023	AKAP6_HUMAN	A kinase (PRKA) anchor protein 6	200					protein targeting	calcium channel complex|nuclear membrane|sarcoplasmic reticulum	protein kinase A binding|receptor binding			NS(2)|breast(10)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(25)|lung(42)|ovary(5)|pancreas(2)|prostate(3)|skin(9)|urinary_tract(2)	122	Breast(36;0.0388)|Prostate(35;0.15)		LUAD - Lung adenocarcinoma(48;0.00107)|Lung(238;0.00677)|STAD - Stomach adenocarcinoma(7;0.116)	GBM - Glioblastoma multiforme(265;0.019)		TTCTCTAACAGAAGTGGATGA	0.398000													4	149					0	0	1	0	0
FAM160B1	57700	broad.mit.edu	37	10	116595331	116595331	+	Silent	SNP	C	C	T			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr10:116595331C>T	ENST00000369248.4	+	4	665	c.330C>T	c.(328-330)ttC>ttT	p.F110F	FAM160B1_ENST00000369250.3_Silent_p.F110F	NM_020940.3	NP_065991.3	Q5W0V3	F16B1_HUMAN	family with sequence similarity 160, member B1	110										NS(1)|central_nervous_system(3)|endometrium(2)|kidney(1)|large_intestine(5)|lung(13)	25						TTTTGGTTTTCTATACGAAAC	0.423000													4	64					0	0	1	0	0
MPP1	4354	broad.mit.edu	37	X	154019323	154019323	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chrX:154019323C>T	ENST00000413259.3	-	5	648	c.256G>A	c.(256-258)Gag>Aag	p.E86K	MPP1_ENST00000462825.1_Intron|MPP1_ENST00000369534.3_Missense_Mutation_p.E116K|MPP1_ENST00000393531.1_Missense_Mutation_p.E116K	NM_001166462.1	NP_001159934.1	Q00013	EM55_HUMAN	membrane protein, palmitoylated 1, 55kDa	116	PDZ.				regulation of neutrophil chemotaxis|signal transduction	integral to plasma membrane|membrane fraction|stereocilium	guanylate kinase activity|protein binding			central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(4)|liver(1)|lung(9)|ovary(2)|prostate(1)	21	all_cancers(53;8.15e-17)|all_epithelial(53;1.1e-10)|all_lung(58;6.63e-07)|Lung NSC(58;2.08e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)					TCTAGGATCTCATCCCCCACG	0.418000													8	137					0	0	1	0	0
PRKAR1B	5575	broad.mit.edu	37	7	645871	645871	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr7:645871C>T	ENST00000406797.1	-	6	682	c.508G>A	c.(508-510)Gaa>Aaa	p.E170K	PRKAR1B_ENST00000403562.1_Missense_Mutation_p.E170K|PRKAR1B_ENST00000537384.1_Missense_Mutation_p.E170K|AC147651.4_ENST00000429872.1_RNA|PRKAR1B_ENST00000544935.1_Missense_Mutation_p.E170K|PRKAR1B_ENST00000360274.4_Missense_Mutation_p.E170K	NM_001164761.1	NP_001158233.1	P31321	KAP1_HUMAN	protein kinase, cAMP-dependent, regulatory, type I, beta	170					activation of phospholipase C activity|activation of protein kinase A activity|blood coagulation|cellular response to glucagon stimulus|energy reserve metabolic process|nerve growth factor receptor signaling pathway|protein phosphorylation|regulation of insulin secretion|transmembrane transport|water transport	cAMP-dependent protein kinase complex|cytosol	cAMP binding|cAMP-dependent protein kinase regulator activity			endometrium(4)|large_intestine(1)|liver(1)|lung(10)|prostate(1)	17		Ovarian(82;0.0779)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0181)|Epithelial(4;5.75e-19)|OV - Ovarian serous cystadenocarcinoma(56;2.01e-18)|all cancers(6;3.96e-16)|BRCA - Breast invasive adenocarcinoma(126;0.152)		TTGTCTCCTTCATTCCCTGTA	0.423000													6	163					0	0	1	0	0
NIPBL	25836	broad.mit.edu	37	5	37027509	37027509	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr5:37027509C>T	ENST00000282516.8	+	32	6356	c.5857C>T	c.(5857-5859)Caa>Taa	p.Q1953*	NIPBL_ENST00000448238.2_Nonsense_Mutation_p.Q1953*	NM_015384.4|NM_133433.3	NP_056199.2|NP_597677.2	Q6KC79	NIPBL_HUMAN	Nipped-B homolog (Drosophila)	1953					brain development|cellular protein localization|cellular response to X-ray|cognition|developmental growth|ear morphogenesis|embryonic arm morphogenesis|embryonic digestive tract morphogenesis|external genitalia morphogenesis|eye morphogenesis|face morphogenesis|gall bladder development|maintenance of mitotic sister chromatid cohesion|metanephros development|negative regulation of transcription from RNA polymerase II promoter|outflow tract morphogenesis|positive regulation of histone deacetylation|regulation of developmental growth|regulation of embryonic development|regulation of hair cycle|response to DNA damage stimulus|sensory perception of sound|uterus morphogenesis	SMC loading complex	chromo shadow domain binding|histone deacetylase binding|protein C-terminus binding|protein N-terminus binding			autonomic_ganglia(1)|breast(4)|endometrium(9)|kidney(22)|large_intestine(21)|liver(1)|lung(47)|ovary(7)|pancreas(1)|prostate(1)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(4)	128	all_lung(31;0.000447)|Hepatocellular(1;0.108)		Epithelial(62;0.072)|COAD - Colon adenocarcinoma(61;0.14)|all cancers(62;0.191)|Colorectal(62;0.202)			GCAACTGCTTCAAAACGTGAG	0.313000													19	106					0	0	1	0	0
OGFOD1	55239	broad.mit.edu	37	16	56485645	56485645	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr16:56485645G>A	ENST00000566157.1	+	1	244	c.121G>A	c.(121-123)Gag>Aag	p.E41K	OGFOD1_ENST00000568397.1_Missense_Mutation_p.E41K	NM_018233.3	NP_060703.3	Q8N543	OGFD1_HUMAN	2-oxoglutarate and iron-dependent oxygenase domain containing 1	41							iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|skin(1)	8					Vitamin C(DB00126)	GCAGGTGGCTGAGGCCTGGAG	0.612000													4	73					0	0	1	0	0
SMAD4	4089	broad.mit.edu	37	18	48591940	48591940	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr18:48591940C>G	ENST00000342988.3	+	9	1641	c.1103C>G	c.(1102-1104)tCc>tGc	p.S368C	SMAD4_ENST00000398417.2_Missense_Mutation_p.S368C|SMAD4_ENST00000588745.1_Missense_Mutation_p.S272C	NM_005359.5	NP_005350.1	Q13485	SMAD4_HUMAN	SMAD family member 4	368	MH2.				BMP signaling pathway|negative regulation of cell growth|negative regulation of protein catabolic process|negative regulation of transcription, DNA-dependent|palate development|positive regulation of epithelial to mesenchymal transition|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of SMAD protein import into nucleus|positive regulation of transforming growth factor beta receptor signaling pathway|regulation of transforming growth factor-beta2 production|response to hypoxia|response to transforming growth factor beta stimulus|SMAD protein complex assembly|SMAD protein signal transduction|transforming growth factor beta receptor signaling pathway	activin responsive factor complex|centrosome|cytosol	I-SMAD binding|protein homodimerization activity|R-SMAD binding|transcription regulatory region DNA binding|transforming growth factor beta receptor, common-partner cytoplasmic mediator activity	p.0?(36)|p.?(2)		NS(2)|biliary_tract(19)|breast(9)|central_nervous_system(2)|endometrium(2)|gastrointestinal_tract_(site_indeterminate)(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(142)|liver(2)|lung(27)|oesophagus(4)|ovary(7)|pancreas(180)|prostate(3)|skin(1)|small_intestine(9)|stomach(5)|testis(2)|thyroid(19)|upper_aerodigestive_tract(10)|urinary_tract(2)|vulva(1)	454		all_cancers(7;0.203)|Colorectal(6;0.003)|all_epithelial(6;0.00336)		Colorectal(16;0.0032)|COAD - Colon adenocarcinoma(17;0.0708)|READ - Rectum adenocarcinoma(32;0.155)		GGTCAACTCTCCAATGTCCAC	0.403000													5	83					0	0	1	0	0
ELF1	1997	broad.mit.edu	37	13	41515396	41515396	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr13:41515396G>A	ENST00000239882.3	-	8	1231	c.917C>T	c.(916-918)tCc>tTc	p.S306F	ELF1_ENST00000498824.1_5'UTR|ELF1_ENST00000442101.1_Missense_Mutation_p.S282F	NM_172373.3	NP_758961.1	P32519	ELF1_HUMAN	E74-like factor 1 (ets domain transcription factor)	306					positive regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(8)|lung(12)|ovary(1)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	37		Lung NSC(96;8.3e-05)|Prostate(109;0.0233)|Breast(139;0.0296)|Lung SC(185;0.0367)		all cancers(112;1.87e-08)|Epithelial(112;8.45e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000202)|GBM - Glioblastoma multiforme(144;0.00266)|BRCA - Breast invasive adenocarcinoma(63;0.072)		CTCTATGCTGGAACTTGGATC	0.418000													9	194					0	0	1	0	0
SPTLC2	9517	broad.mit.edu	37	14	78028818	78028818	+	Silent	SNP	C	C	G			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr14:78028818C>G	ENST00000216484.2	-	6	964	c.771G>C	c.(769-771)ctG>ctC	p.L257L		NM_004863.3	NP_004854.1	O15270	SPTC2_HUMAN	serine palmitoyltransferase, long chain base subunit 2	257						integral to membrane|serine C-palmitoyltransferase complex	pyridoxal phosphate binding|serine C-palmitoyltransferase activity|transferase activity, transferring nitrogenous groups			kidney(1)|large_intestine(5)|lung(5)|ovary(1)|skin(2)|upper_aerodigestive_tract(5)	19			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0346)	L-Serine(DB00133)|Pyridoxal Phosphate(DB00114)	GTTCATCACTCAGAATCAGGC	0.433000													7	79					0	0	1	0	0
CASKIN2	57513	broad.mit.edu	37	17	73498870	73498870	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr17:73498870G>A	ENST00000321617.3	-	18	2871	c.2285C>T	c.(2284-2286)tCa>tTa	p.S762L	CASKIN2_ENST00000433559.2_Missense_Mutation_p.S680L	NM_020753.3	NP_065804.2	Q8WXE0	CSKI2_HUMAN	CASK interacting protein 2	762	Pro-rich.					cytoplasm				endometrium(1)|kidney(3)|lung(7)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(1)	18	all_cancers(13;3.15e-09)|all_epithelial(9;5.78e-10)|Breast(9;5.8e-10)|all_lung(278;0.246)		all cancers(21;4.57e-07)|Epithelial(20;2.92e-06)|Lung(188;0.0809)|LUSC - Lung squamous cell carcinoma(166;0.154)			GCTAGAGGGTGAGCCCTGGGG	0.657000													4	69					0	0	1	0	0
KLHL11	55175	broad.mit.edu	37	17	40010360	40010360	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr17:40010360C>T	ENST00000319121.3	-	2	1819	c.1759G>A	c.(1759-1761)Gag>Aag	p.E587K		NM_018143.1	NP_060613.1	Q9NVR0	KLH11_HUMAN	kelch-like family member 11	587						extracellular region				NS(2)|breast(2)|endometrium(1)|large_intestine(2)|lung(5)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	17		Breast(137;0.00156)				TCAAGGATCTCATCAGACACT	0.408000													8	146					0	0	1	0	0
PRIM1	5557	broad.mit.edu	37	12	57135604	57135604	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr12:57135604G>A	ENST00000338193.6	-	8	802	c.766C>T	c.(766-768)Caa>Taa	p.Q256*		NM_000946.2	NP_000937.1	P49642	PRI1_HUMAN	primase, DNA, polypeptide 1 (49kDa)	256					DNA replication, synthesis of RNA primer|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication	alpha DNA polymerase:primase complex|nucleoplasm	DNA primase activity|metal ion binding			kidney(1)|lung(6)|prostate(1)	8						AAGCTTTGTTGAAGTTCATCA	0.383000													5	223					0	0	1	0	0
PCDHA3	56145	broad.mit.edu	37	5	140180825	140180825	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr5:140180825C>G	ENST00000522353.2	+	1	43	c.43C>G	c.(43-45)Ctg>Gtg	p.L15V	PCDHA1_ENST00000504120.2_Intron|PCDHA2_ENST00000520672.2_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA3_ENST00000532566.2_Missense_Mutation_p.L15V	NM_018906.2	NP_061729.1														NS(1)|breast(1)|endometrium(16)|kidney(3)|large_intestine(19)|lung(36)|ovary(7)|prostate(8)|skin(3)|stomach(1)	95			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCAGTGCCTGCTGCTTTCTCT	0.512000													7	115					0	0	1	0	0
SCRG1	11341	broad.mit.edu	37	4	174309513	174309513	+	Silent	SNP	C	C	T			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr4:174309513C>T	ENST00000296506.2	-	3	758	c.276G>A	c.(274-276)gtG>gtA	p.V92V		NM_007281.2	NP_009212.1	O75711	SCRG1_HUMAN	stimulator of chondrogenesis 1	92					nervous system development	extracellular space				large_intestine(1)|lung(4)|skin(1)	6		Prostate(90;0.00601)|Renal(120;0.0183)|Melanoma(52;0.0749)|all_neural(102;0.0837)|all_hematologic(60;0.107)		all cancers(43;1.15e-17)|Epithelial(43;4.33e-16)|OV - Ovarian serous cystadenocarcinoma(60;6.62e-09)|STAD - Stomach adenocarcinoma(60;0.00278)|GBM - Glioblastoma multiforme(59;0.00659)|LUSC - Lung squamous cell carcinoma(193;0.0919)		TGCAAGGAATCACGAAAGAGA	0.353000													7	107					0	0	1	0	0
TMEM95	339168	broad.mit.edu	37	17	7259784	7259784	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr17:7259784G>A	ENST00000389982.4	+	6	557	c.475G>A	c.(475-477)Gag>Aag	p.E159K	TMEM95_ENST00000576060.1_Silent_p.L161L|TMEM95_ENST00000330767.4_Silent_p.L169L			Q3KNT9	TMM95_HUMAN	transmembrane protein 95	0						integral to membrane				large_intestine(1)|lung(2)	3		Prostate(122;0.173)				TGGGTGTTCTGAGCCTCCTGG	0.577000											OREG0024137	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	6	303					0	0	1	0	0
IFNGR2	3460	broad.mit.edu	37	21	34799243	34799243	+	Silent	SNP	C	C	T			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr21:34799243C>T	ENST00000290219.6	+	4	1113	c.465C>T	c.(463-465)ctC>ctT	p.L155L	IFNGR2_ENST00000381995.1_Silent_p.L174L|IFNGR2_ENST00000405436.1_Silent_p.L76L	NM_005534.3	NP_005525.2	P38484	INGR2_HUMAN	interferon gamma receptor 2 (interferon gamma transducer 1)	155	Fibronectin type-III 2.				regulation of interferon-gamma-mediated signaling pathway|response to virus	endoplasmic reticulum|integral to plasma membrane	interferon-gamma receptor activity			NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(3)|urinary_tract(1)	13					Interferon gamma-1b(DB00033)	AAGGCTCCCTCATCATCAGGT	0.443000													15	268					0	0	1	0	0
SMARCE1	6605	broad.mit.edu	37	17	38788614	38788614	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr17:38788614C>G	ENST00000348513.6	-	8	1327	c.547G>C	c.(547-549)Gat>Cat	p.D183H	SMARCE1_ENST00000431889.2_Missense_Mutation_p.D165H|SMARCE1_ENST00000544009.1_Missense_Mutation_p.D113H|SMARCE1_ENST00000580419.1_Missense_Mutation_p.D148H|SMARCE1_ENST00000377808.4_Missense_Mutation_p.D148H|SMARCE1_ENST00000400122.3_Missense_Mutation_p.D113H|SMARCE1_ENST00000578044.1_Missense_Mutation_p.D113H|KRT222_ENST00000476049.1_3'UTR	NM_003079.4	NP_003070.3	Q969G3	SMCE1_HUMAN	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1	183					chromatin modification|negative regulation of transcription, DNA-dependent|nervous system development|nucleosome disassembly|regulation of transcription from RNA polymerase II promoter	nBAF complex|npBAF complex|nuclear chromosome|SWI/SNF complex|transcriptional repressor complex	chromatin binding|DNA binding|N-acetyltransferase activity|protein binding|protein N-terminus binding|transcription coactivator activity			large_intestine(1)	1		Breast(137;0.000812)				AAGCCATCATCATAATCTGGA	0.438000													5	63					0	0	1	0	0
BRCA1	672	broad.mit.edu	37	17	41249303	41249303	+	Translation_Start_Site	SNP	G	G	C			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr17:41249303G>C	ENST00000309486.4	-	0	690				BRCA1_ENST00000354071.3_Missense_Mutation_p.S184C|BRCA1_ENST00000351666.3_Intron|BRCA1_ENST00000591849.1_Intron|BRCA1_ENST00000591534.1_Intron|BRCA1_ENST00000352993.3_Missense_Mutation_p.S184C|BRCA1_ENST00000586385.1_Intron|BRCA1_ENST00000357654.3_Missense_Mutation_p.S184C|BRCA1_ENST00000346315.3_Missense_Mutation_p.S184C|BRCA1_ENST00000491747.2_Missense_Mutation_p.S184C|BRCA1_ENST00000468300.1_Missense_Mutation_p.S184C|BRCA1_ENST00000471181.2_Missense_Mutation_p.S184C|BRCA1_ENST00000493795.1_Missense_Mutation_p.S137C	NM_007297.3	NP_009228.2	P38398	BRCA1_HUMAN	breast cancer 1, early onset						androgen receptor signaling pathway|apoptosis|cellular response to indole-3-methanol|chromosome segregation|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|DNA damage response, signal transduction resulting in induction of apoptosis|double-strand break repair via homologous recombination|fatty acid biosynthetic process|G2/M transition DNA damage checkpoint|negative regulation of centriole replication|negative regulation of fatty acid biosynthetic process|negative regulation of histone H3-K9 methylation|negative regulation of transcription, DNA-dependent|positive regulation of cell cycle arrest|positive regulation of DNA repair|positive regulation of histone acetylation|positive regulation of histone H3-K4 methylation|positive regulation of histone H4-K20 methylation|positive regulation of protein ubiquitination|positive regulation of transcription from RNA polymerase II promoter|postreplication repair|protein autoubiquitination|protein K6-linked ubiquitination|regulation of cell motility|regulation of cell proliferation|regulation of transcription from RNA polymerase III promoter|response to estrogen stimulus|response to ionizing radiation|substrate adhesion-dependent cell spreading	BRCA1-A complex|BRCA1-BARD1 complex|gamma-tubulin ring complex|nucleoplasm|plasma membrane|ribonucleoprotein complex|ruffle	androgen receptor binding|identical protein binding|protein binding|RNA binding|transcription coactivator activity|transcription regulatory region DNA binding|tubulin binding|ubiquitin protein ligase binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|breast(30)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(7)|lung(28)|ovary(36)|skin(2)|stomach(4)|urinary_tract(2)	120		Breast(137;0.000717)		BRCA - Breast invasive adenocarcinoma(366;0.126)		AGAAGAATCAGATCCTAAAAA	0.284000			"""D, Mis, N, F, S"""		ovarian	"""breast, ovarian"""		Homologous recombination	Hereditary Breast-Ovarian Cancer, BRCA1 type	TCGA Ovarian(2;0.000030)			7	143					0	0	1	0	0
DLEC1	9940	broad.mit.edu	37	3	38138180	38138180	+	Silent	SNP	C	C	T			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr3:38138180C>T	ENST00000308059.6	+	15	2313	c.2292C>T	c.(2290-2292)atC>atT	p.I764I	DLEC1_ENST00000452631.2_Silent_p.I764I|DLEC1_ENST00000346219.3_Silent_p.I764I			Q9Y238	DLEC1_HUMAN	deleted in lung and esophageal cancer 1	764					negative regulation of cell proliferation	cytoplasm				NS(1)|breast(3)|central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(14)|ovary(3)|pancreas(3)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)	51				KIRC - Kidney renal clear cell carcinoma(284;0.0664)|Kidney(284;0.0827)		ATGCCCTCATCATCCCAGGGG	0.498000													13	191					0	0	1	0	0
DNAH10	196385	broad.mit.edu	37	12	124257476	124257476	+	Silent	SNP	C	C	T			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr12:124257476C>T	ENST00000409039.3	+	4	334	c.309C>T	c.(307-309)ctC>ctT	p.L103L		NM_207437.3	NP_997320.2	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	103	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(14)|ovary(4)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	52	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		TGTTTTTCCTCAGAAATACCA	0.463000													7	87					0	0	1	0	0
GMPS	8833	broad.mit.edu	37	3	155615828	155615828	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr3:155615828C>T	ENST00000496455.1	+	3	657	c.322C>T	c.(322-324)Cag>Tag	p.Q108*	GMPS_ENST00000295920.7_Intron|GMPS_ENST00000476145.1_3'UTR	NM_003875.2	NP_003866.1	P49915	GUAA_HUMAN	guanine monphosphate synthase	108	Glutamine amidotransferase type-1.				glutamine metabolic process|purine base biosynthetic process	cytosol	ATP binding|GMP synthase (glutamine-hydrolyzing) activity|GMP synthase activity			breast(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(5)|lung(12)|ovary(2)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	32			Lung(72;0.11)|LUSC - Lung squamous cell carcinoma(72;0.114)		L-Glutamic Acid(DB00142)|L-Glutamine(DB00130)	CTATGGTATGCAGGTATGTCA	0.363000			T	MLL	AML								5	243					0	0	1	0	0
GAL3ST3	89792	broad.mit.edu	37	11	65810634	65810634	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr11:65810634C>G	ENST00000312006.4	-	3	921	c.640G>C	c.(640-642)Gag>Cag	p.E214Q	GAL3ST3_ENST00000527878.1_Missense_Mutation_p.E214Q	NM_033036.2	NP_149025.1	Q96A11	G3ST3_HUMAN	galactose-3-O-sulfotransferase 3	214					monosaccharide metabolic process|oligosaccharide metabolic process|poly-N-acetyllactosamine metabolic process|proteoglycan biosynthetic process|sulfur compound metabolic process	Golgi cisterna membrane|integral to membrane	3'-phosphoadenosine 5'-phosphosulfate binding|carbohydrate binding|galactosylceramide sulfotransferase activity|proteoglycan sulfotransferase activity			kidney(1)|lung(9)|ovary(2)|skin(2)	14						GGGCTGCGCTCATTGTCGCCG	0.672000													4	94					0	0	1	0	0
ADCY9	115	broad.mit.edu	37	16	4164326	4164326	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr16:4164326G>C	ENST00000294016.3	-	2	1656	c.1118C>G	c.(1117-1119)tCt>tGt	p.S373C		NM_001116.3	NP_001107.2	O60503	ADCY9_HUMAN	adenylate cyclase 9	373					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding			breast(4)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(3)|large_intestine(11)|lung(9)|ovary(5)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	47						TTGGATGGAAGACTTTTTCTT	0.453000													5	122					0	0	1	0	0
SCN1A	6323	broad.mit.edu	37	2	166859020	166859020	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr2:166859020C>T	ENST00000423058.2	-	21	4263	c.4246G>A	c.(4246-4248)Gat>Aat	p.D1416N	SCN1A_ENST00000375405.3_Missense_Mutation_p.D1405N|AC010127.3_ENST00000595647.1_RNA|SCN1A_ENST00000303395.4_Missense_Mutation_p.D1416N|SCN1A_ENST00000409050.1_Missense_Mutation_p.D1388N|AC010127.3_ENST00000597623.1_RNA	NM_001165963.1|NM_001202435.1	NP_001159435.1|NP_001189364.1	P35498	SCN1A_HUMAN	sodium channel, voltage-gated, type I, alpha subunit	1416						voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(4)|breast(5)|endometrium(16)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(33)|lung(87)|ovary(7)|pancreas(1)|prostate(9)|skin(23)|upper_aerodigestive_tract(2)|urinary_tract(1)	200					Lamotrigine(DB00555)|Levetiracetam(DB01202)|Phenacemide(DB01121)|Phenytoin(DB00252)|Topiramate(DB00273)|Zonisamide(DB00909)	CCTACATTATCAAAGTTTACT	0.308000													4	62					0	0	1	0	0
MAEA	10296	broad.mit.edu	37	4	1316234	1316234	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr4:1316234G>C	ENST00000303400.4	+	4	585	c.522G>C	c.(520-522)gaG>gaC	p.E174D	MAEA_ENST00000452175.2_Missense_Mutation_p.E95D|MAEA_ENST00000505177.2_Missense_Mutation_p.E174D|MAEA_ENST00000514708.1_Intron|MAEA_ENST00000510794.1_Missense_Mutation_p.E173D|MAEA_ENST00000264750.6_Intron|MAEA_ENST00000505839.1_Missense_Mutation_p.E126D	NM_001017405.1	NP_001017405.1	Q7L5Y9	MAEA_HUMAN	macrophage erythroblast attacher	174	CTLH.				cell adhesion|cell cycle|cell division|erythrocyte maturation|negative regulation of myeloid cell apoptosis|regulation of mitotic cell cycle	actomyosin contractile ring|integral to plasma membrane|membrane fraction|nuclear matrix|spindle	actin binding			NS(2)|central_nervous_system(1)|endometrium(2)|large_intestine(5)|lung(2)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	18			OV - Ovarian serous cystadenocarcinoma(23;0.0201)			AGAGGCGTGAGACGGCCACCT	0.597000													4	95					0	0	1	0	0
PLK4	10733	broad.mit.edu	37	4	128806873	128806873	+	Silent	SNP	C	C	T			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr4:128806873C>T	ENST00000270861.5	+	5	622	c.348C>T	c.(346-348)ttC>ttT	p.F116F	PLK4_ENST00000514379.1_Silent_p.F75F|PLK4_ENST00000515069.1_Silent_p.F116F|PLK4_ENST00000513090.1_Silent_p.F84F|PLK4_ENST00000507249.1_Silent_p.F116F	NM_014264.4	NP_055079.3	O00444	PLK4_HUMAN	polo-like kinase 4	116	Protein kinase.				G2/M transition of mitotic cell cycle|positive regulation of centriole replication|trophoblast giant cell differentiation	centriole|cleavage furrow|cytosol|nucleolus	ATP binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(10)|lung(12)|prostate(1)|upper_aerodigestive_tract(1)	31						CTCGACACTTCATGCACCAGA	0.368000													13	173					0	0	1	0	0
CNTN2	6900	broad.mit.edu	37	1	205027780	205027780	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr1:205027780C>T	ENST00000331830.4	+	5	760	c.476C>T	c.(475-477)gCc>gTc	p.A159V		NM_005076.3	NP_005067.1	Q02246	CNTN2_HUMAN	contactin 2 (axonal)	159	Ig-like C2-type 2.				axon guidance|clustering of voltage-gated potassium channels	anchored to membrane|juxtaparanode region of axon|myelin sheath|node of Ranvier|synapse part	identical protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(11)|lung(23)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	54	all_cancers(21;0.144)|Breast(84;0.0437)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.158)			AACCCACCTGCCCACTACCCA	0.577000													3	24					0	0	1	0	0
ARHGAP12	94134	broad.mit.edu	37	10	32128591	32128591	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr10:32128591G>A	ENST00000311380.4	-	5	1222	c.1204C>T	c.(1204-1206)Ccc>Tcc	p.P402S	ARHGAP12_ENST00000375250.5_Intron|ARHGAP12_ENST00000375245.4_Missense_Mutation_p.P402S|ARHGAP12_ENST00000396144.4_Missense_Mutation_p.P449S|ARHGAP12_ENST00000344936.2_Missense_Mutation_p.P449S	NM_001270697.1|NM_001270699.1	NP_001257626.1|NP_001257628.1	Q8IWW6	RHG12_HUMAN	Rho GTPase activating protein 12	449					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			NS(1)|breast(3)|endometrium(2)|kidney(1)|large_intestine(11)|lung(10)|skin(1)|urinary_tract(2)	31		Prostate(175;0.0199)				GGTGAGGAGGGAGAAGACTCA	0.308000													5	52					0	0	1	0	0
GPR37	2861	broad.mit.edu	37	7	124387288	124387288	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr7:124387288G>A	ENST00000303921.2	-	2	1783	c.1133C>T	c.(1132-1134)tCa>tTa	p.S378L		NM_005302.2	NP_005293.1	O15354	GPR37_HUMAN	G protein-coupled receptor 37 (endothelin receptor type B-like)	378						endoplasmic reticulum membrane|integral to plasma membrane	G-protein coupled receptor activity			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(5)|large_intestine(8)|lung(11)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	36						GGCAGTTGTTGAGGAACAGTT	0.483000													6	77					0	0	1	0	0
ENPP3	5169	broad.mit.edu	37	6	132068003	132068003	+	Silent	SNP	C	C	T			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr6:132068003C>T	ENST00000414305.1	+	26	2863	c.2535C>T	c.(2533-2535)ctC>ctT	p.L845L	ENPP3_ENST00000357639.3_Silent_p.L845L|ENPP3_ENST00000358229.5_3'UTR			O14638	ENPP3_HUMAN	ectonucleotide pyrophosphatase/phosphodiesterase 3	845	Nuclease.				immune response|nucleoside triphosphate catabolic process|phosphate metabolic process	extracellular region|integral to plasma membrane|perinuclear region of cytoplasm	metal ion binding|nucleic acid binding|nucleoside-triphosphate diphosphatase activity|nucleotide diphosphatase activity|phosphodiesterase I activity|polysaccharide binding|scavenger receptor activity			NS(1)|breast(2)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(5)|lung(24)|ovary(3)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	53	Breast(56;0.0753)			GBM - Glioblastoma multiforme(226;0.0252)|OV - Ovarian serous cystadenocarcinoma(155;0.0511)		TAGAACTTCTCACTGGGCTTG	0.388000													10	164					0	0	1	0	0
TRRAP	8295	broad.mit.edu	37	7	98522761	98522761	+	Silent	SNP	G	G	A			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr7:98522761G>A	ENST00000359863.4	+	22	3059	c.2850G>A	c.(2848-2850)ctG>ctA	p.L950L	TRRAP_ENST00000446306.3_Silent_p.L949L|TRRAP_ENST00000355540.3_Silent_p.L950L	NM_001244580.1	NP_001231509.1	Q9Y4A5	TRRAP_HUMAN	transformation/transcription domain-associated protein	950					histone deubiquitination|histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|PCAF complex|STAGA complex|transcription factor TFTC complex	phosphotransferase activity, alcohol group as acceptor|protein binding|transcription cofactor activity			NS(3)|breast(1)|central_nervous_system(10)|endometrium(16)|kidney(7)|large_intestine(36)|liver(1)|lung(54)|ovary(10)|pancreas(1)|prostate(8)|skin(16)|stomach(5)|upper_aerodigestive_tract(6)|urinary_tract(2)	176	all_cancers(62;6.96e-09)|all_epithelial(64;4.86e-09)|Lung NSC(181;0.01)|all_lung(186;0.016)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)			TGGACTGCCTGAAAAGCGCCA	0.488000													7	51					0	0	1	0	0
DCLK1	9201	broad.mit.edu	37	13	36700207	36700207	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr13:36700207C>T	ENST00000255448.4	-	2	279	c.68G>A	c.(67-69)cGa>cAa	p.R23Q	DCLK1_ENST00000379892.4_Missense_Mutation_p.R23Q|DCLK1_ENST00000360631.3_Missense_Mutation_p.R23Q	NM_004734.4	NP_004725.1	O15075	DCLK1_HUMAN	doublecortin-like kinase 1	23					cell differentiation|central nervous system development|endosome transport|intracellular signal transduction|response to virus	integral to plasma membrane	ATP binding|protein serine/threonine kinase activity|receptor signaling protein activity			breast(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(18)|lung(17)|ovary(2)|prostate(3)|skin(4)|stomach(6)|urinary_tract(1)	64		Breast(139;0.0147)|Lung SC(185;0.0685)|Prostate(109;0.122)	KIRC - Kidney renal clear cell carcinoma(5;0.119)|Kidney(79;0.169)	all cancers(112;1.72e-06)|Epithelial(112;4.24e-05)|BRCA - Breast invasive adenocarcinoma(63;0.00159)|OV - Ovarian serous cystadenocarcinoma(117;0.0158)|GBM - Glioblastoma multiforme(144;0.0638)		CCGCGACCCTCGGCTGTATCT	0.637000													10	133					0	0	1	0	0
CKAP4	10970	broad.mit.edu	37	12	106633715	106633715	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr12:106633715G>A	ENST00000378026.4	-	2	1032	c.896C>T	c.(895-897)tCa>tTa	p.S299L	CKAP4_ENST00000552828.1_5'UTR	NM_006825.3	NP_006816.2	Q07065	CKAP4_HUMAN	cytoskeleton-associated protein 4	299						ER-Golgi intermediate compartment membrane|integral to membrane|membrane fraction				NS(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(8)|pancreas(1)|urinary_tract(1)	20						GGACTTGGCTGAGGTCTGTAT	0.517000													5	161					0	0	1	0	0
VCAM1	7412	broad.mit.edu	37	1	101190204	101190204	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr1:101190204C>T	ENST00000294728.2	+	4	787	c.686C>T	c.(685-687)tCt>tTt	p.S229F	VCAM1_ENST00000347652.2_Missense_Mutation_p.S229F|VCAM1_ENST00000370115.1_Missense_Mutation_p.S229F|VCAM1_ENST00000370119.4_Missense_Mutation_p.S167F	NM_001078.3	NP_001069.1	P19320	VCAM1_HUMAN	vascular cell adhesion molecule 1	229	Ig-like C2-type 3.				heterophilic cell-cell adhesion|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|leukocyte tethering or rolling|membrane to membrane docking|positive regulation of T cell proliferation|regulation of immune response	alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex|apical part of cell|external side of plasma membrane|extracellular space|filopodium|integral to membrane|microvillus|podosome	cell adhesion molecule binding|integrin binding			central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|liver(1)|lung(27)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	56		all_epithelial(167;3.83e-06)|all_lung(203;0.000485)|Lung NSC(277;0.0011)		Epithelial(280;0.0227)|all cancers(265;0.0276)|COAD - Colon adenocarcinoma(174;0.149)|Colorectal(144;0.169)|Lung(183;0.196)	Carvedilol(DB01136)	ACAGTTATTTCTGTGAATCCA	0.413000													10	143					0	0	1	0	0
BCL2L12	83596	broad.mit.edu	37	19	50169080	50169080	+	Translation_Start_Site	SNP	G	G	A			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr19:50169080G>A	ENST00000246785.3	+	0	258				BCL2L12_ENST00000441864.2_De_novo_Start_InFrame|IRF3_ENST00000598808.1_5'UTR|IRF3_ENST00000597198.1_5'UTR|BCL2L12_ENST00000246784.3_Intron|IRF3_ENST00000377139.3_5'UTR	NM_001040668.1|NM_138639.1	NP_001035758.1|NP_619580.1	Q9HB09	B2L12_HUMAN	BCL2-like 12 (proline rich)						apoptosis					central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(2)|skin(1)	8		all_lung(116;3.24e-07)|Lung NSC(112;1.6e-06)|all_neural(266;0.0459)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.000681)|GBM - Glioblastoma multiforme(134;0.0214)		CCCAAAAGCCGATGGGACGGC	0.532000													4	83					0	0	1	0	0
POLR2J	5439	broad.mit.edu	37	7	102119287	102119287	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr7:102119287G>C	ENST00000292614.5	-	1	67	c.21C>G	c.(19-21)ttC>ttG	p.F7L	POLR2J_ENST00000393794.3_Missense_Mutation_p.F7L	NM_006234.4	NP_006225.1	P52435	RPB11_HUMAN	polymerase (RNA) II (DNA directed) polypeptide J, 13.3kDa	7					mRNA capping|nuclear mRNA splicing, via spliceosome|positive regulation of viral transcription|protein phosphorylation|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	DNA-directed RNA polymerase II, core complex	DNA binding|DNA-directed RNA polymerase activity|LRR domain binding|protein dimerization activity			pancreas(2)	2						AGAACGACTCGAAGGCTGGAG	0.677000											OREG0018232	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	3	44					0	0	1	0	0
AAR2	25980	broad.mit.edu	37	20	34843614	34843614	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr20:34843614G>C	ENST00000373932.3	+	4	1448	c.1102G>C	c.(1102-1104)Gag>Cag	p.E368Q	AAR2_ENST00000320849.4_Missense_Mutation_p.E368Q|AAR2_ENST00000397286.3_Intron	NM_015511.3	NP_056326.2			AAR2 splicing factor homolog (S. cerevisiae)																		TGCGGAACCTGAGGACTGTGC	0.617000													4	81					0	0	1	0	0
NUDCD3	23386	broad.mit.edu	37	7	44524878	44524878	+	Silent	SNP	G	G	A			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr7:44524878G>A	ENST00000355451.6	-	2	477	c.198C>T	c.(196-198)ttC>ttT	p.F66F		NM_015332.3	NP_056147.2	Q8IVD9	NUDC3_HUMAN	NudC domain containing 3	66										endometrium(2)|large_intestine(1)|lung(3)|skin(1)	7						CAAAGGTTTTGAATACCTAAA	0.418000													7	78					0	0	1	0	0
RMI1	80010	broad.mit.edu	37	9	86617353	86617353	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr9:86617353G>A	ENST00000325875.3	+	3	1784	c.1452G>A	c.(1450-1452)atG>atA	p.M484I		NM_024945.2	NP_079221.2	Q9H9A7	RMI1_HUMAN	RecQ mediated genome instability 1	484					DNA replication	nucleus				biliary_tract(1)|central_nervous_system(1)|kidney(2)|large_intestine(7)|lung(3)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	18						CTATTGCCATGGATTTGTATT	0.318000													5	150					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179475984	179475984	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr2:179475984C>G	ENST00000589042.1	-	270	51096	c.50872G>C	c.(50872-50874)Gac>Cac	p.D16958H	TTN-AS1_ENST00000589487.1_RNA|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000589234.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.D15317H|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000589830.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.D7893H|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.D8085H|TTN-AS1_ENST00000456053.1_RNA|TTN-AS1_ENST00000589907.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.D8018H|TTN_ENST00000342992.6_Missense_Mutation_p.D14390H	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	15317	Fibronectin type-III 23.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GTCTCCAGGTCAATTGTTGGC	0.353000													5	36					0	0	1	0	0
MLLT3	4300	broad.mit.edu	37	9	20414340	20414340	+	Silent	SNP	G	G	A			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr9:20414340G>A	ENST00000380338.4	-	5	790	c.504C>T	c.(502-504)agC>agT	p.S168S	MLLT3_ENST00000355930.6_5'UTR|MLLT3_ENST00000429426.2_Silent_p.S165S|MLLT3_ENST00000475957.1_5'UTR	NM_004529.2	NP_004520.2	P42568	AF9_HUMAN	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3	168	Poly-Ser.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding	p.S168S(5)		central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(6)|lung(24)|ovary(1)|prostate(4)|skin(1)|urinary_tract(7)	66				GBM - Glioblastoma multiforme(3;4.35e-105)|Lung(42;3.48e-06)|LUSC - Lung squamous cell carcinoma(42;7.92e-05)		tgctgctgctgctactgctgc	0.537000			T	MLL	ALL								9	100					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179401824	179401824	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr2:179401824C>T	ENST00000589042.1	-	356	100236	c.100012G>A	c.(100012-100014)Gaa>Aaa	p.E33338K	TTN-AS1_ENST00000585358.1_RNA|TTN-AS1_ENST00000588244.1_RNA|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000588257.1_RNA|TTN-AS1_ENST00000450692.2_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.E31697K|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000586831.1_RNA|TTN-AS1_ENST00000586707.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000589434.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.E24273K|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000592600.1_RNA|TTN-AS1_ENST00000588804.1_RNA|TTN-AS1_ENST00000592836.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.E24465K|TTN-AS1_ENST00000456053.1_RNA|TTN-AS1_ENST00000591466.1_RNA|TTN-AS1_ENST00000590040.1_RNA|TTN-AS1_ENST00000591867.1_RNA|TTN-AS1_ENST00000589391.1_RNA|TTN-AS1_ENST00000431259.2_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN-AS1_ENST00000592182.1_RNA|TTN-AS1_ENST00000588716.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.E24398K|TTN_ENST00000342992.6_Missense_Mutation_p.E30770K|TTN-AS1_ENST00000585487.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	31697	Ig-like 146.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AATTGCCATTCAGCCCCCTCC	0.507000													7	55					0	0	1	0	0
ZNF420	147923	broad.mit.edu	37	19	37619055	37619055	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr19:37619055G>A	ENST00000337995.3	+	5	1377	c.1162G>A	c.(1162-1164)Gaa>Aaa	p.E388K	ZNF420_ENST00000304239.7_Missense_Mutation_p.E388K|ZNF585A_ENST00000588723.1_Intron	NM_144689.3	NP_653290.2	Q8TAQ5	ZN420_HUMAN	zinc finger protein 420	388					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(2)|large_intestine(9)|lung(10)|prostate(1)|skin(3)	27			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			TCACACCAATGAAAAGCCCTA	0.408000													7	116					0	0	1	0	0
ANKEF1	63926	broad.mit.edu	37	20	10025043	10025043	+	Splice_Site	SNP	C	C	T			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr20:10025043C>T	ENST00000378380.3	+	4	877	c.546_splice	c.e4-1	p.S183_splice	SNAP25-AS1_ENST00000421143.2_RNA|ANKEF1_ENST00000378392.1_Splice_Site_p.S183_splice|SNAP25-AS1_ENST00000603542.1_RNA|ANKEF1_ENST00000488991.1_3'UTR	NM_198798.1	NP_942093.1			ankyrin repeat and EF-hand domain containing 1																		CATGTCCAGTCCACAGGCCGC	0.413000													6	105					0	0	1	0	0
SKI	6497	broad.mit.edu	37	1	2234792	2234792	+	Silent	SNP	G	G	A			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr1:2234792G>A	ENST00000378536.4	+	3	1236	c.1164G>A	c.(1162-1164)gcG>gcA	p.A388A	SKI_ENST00000478223.2_3'UTR	NM_003036.3	NP_003027.1	P12755	SKI_HUMAN	v-ski avian sarcoma viral oncogene homolog	388					anterior/posterior axis specification|BMP signaling pathway|bone morphogenesis|cell motility|cell proliferation|embryonic limb morphogenesis|face morphogenesis|lens morphogenesis in camera-type eye|myelination in peripheral nervous system|myotube differentiation|negative regulation of activin receptor signaling pathway|negative regulation of BMP signaling pathway|negative regulation of fibroblast proliferation|negative regulation of osteoblast differentiation|negative regulation of Schwann cell proliferation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transforming growth factor beta receptor signaling pathway|neural tube closure|nose morphogenesis|olfactory bulb development|palate development|positive regulation of DNA binding|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway|protein homotrimerization|regulation of apoptosis|retina development in camera-type eye|skeletal muscle fiber development|SMAD protein signal transduction|somatic stem cell maintenance|transcription, DNA-dependent|transforming growth factor beta receptor signaling pathway	cytoplasm|PML body|transcription factor complex|transcriptional repressor complex	histone deacetylase inhibitor activity|nucleotide binding|protein domain specific binding|protein kinase binding|repressing transcription factor binding|SMAD binding|transcription corepressor activity|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding			central_nervous_system(1)|kidney(2)|lung(5)|prostate(1)|stomach(1)	10	all_cancers(77;0.000139)|all_epithelial(69;4.45e-05)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)			Epithelial(90;2.14e-37)|OV - Ovarian serous cystadenocarcinoma(86;2.72e-29)|GBM - Glioblastoma multiforme(42;2.45e-08)|Colorectal(212;5.33e-05)|COAD - Colon adenocarcinoma(227;0.000228)|Kidney(185;0.00268)|BRCA - Breast invasive adenocarcinoma(365;0.00471)|STAD - Stomach adenocarcinoma(132;0.0147)|KIRC - Kidney renal clear cell carcinoma(229;0.0385)|Lung(427;0.207)		CAGTGTCAGCGAGTGAGAAAG	0.622000													10	199					0	0	1	0	0
TTK	7272	broad.mit.edu	37	6	80718147	80718147	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr6:80718147G>C	ENST00000509894.1	+	4	1236	c.407G>C	c.(406-408)aGa>aCa	p.R136T	TTK_ENST00000369798.2_Missense_Mutation_p.R136T|TTK_ENST00000230510.3_Missense_Mutation_p.R136T			P33981	TTK_HUMAN	TTK protein kinase	136					mitotic cell cycle spindle assembly checkpoint|mitotic spindle organization|positive regulation of cell proliferation|positive regulation of pathway-restricted SMAD protein phosphorylation	spindle	ATP binding|identical protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			endometrium(4)|kidney(2)|large_intestine(12)|lung(22)|ovary(7)|pancreas(1)|prostate(1)|stomach(3)|urinary_tract(1)	53		all_cancers(76;0.00177)|Acute lymphoblastic leukemia(125;1.24e-05)|all_hematologic(105;0.00223)|all_epithelial(107;0.2)		BRCA - Breast invasive adenocarcinoma(397;0.0321)		CAAATGGCCAGAGCAAACTGC	0.303000													9	190					0	0	1	0	0
SERPINA6	866	broad.mit.edu	37	14	94780855	94780855	+	Missense_Mutation	SNP	A	A	G			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr14:94780855A>G	ENST00000341584.3	-	2	277	c.131T>C	c.(130-132)gTt>gCt	p.V44A		NM_001756.3	NP_001747.2	P08185	CBG_HUMAN	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6	44					regulation of proteolysis|transport	extracellular space	serine-type endopeptidase inhibitor activity|steroid binding			central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(11)|ovary(1)|skin(4)|upper_aerodigestive_tract(1)	26		all_cancers(154;0.0482)|all_epithelial(191;0.166)		COAD - Colon adenocarcinoma(157;0.211)	Alclometasone(DB00240)|Beclomethasone(DB00394)|Ciclesonide(DB01410)|Flumethasone Pivalate(DB00663)|Flunisolide(DB00180)|Fluocinolone Acetonide(DB00591)|Fluocinonide(DB01047)|Fluorometholone(DB00324)|Flurandrenolide(DB00846)|Fluticasone Propionate(DB00588)|Halobetasol Propionate(DB00596)|Medrysone(DB00253)|Mitotane(DB00648)|Paramethasone(DB01384)|Prednisolone(DB00860)|Rimexolone(DB00896)|Triamcinolone(DB00620)	GGCAAAGTCAACGTTGGCTGA	0.542000													18	111					0	0	1	0	0
CARD6	84674	broad.mit.edu	37	5	40841605	40841605	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr5:40841605G>A	ENST00000254691.5	+	1	320	c.121G>A	c.(121-123)Gag>Aag	p.E41K	CARD6_ENST00000381677.3_Missense_Mutation_p.E41K	NM_032587.3	NP_115976.2	Q9BX69	CARD6_HUMAN	caspase recruitment domain family, member 6	41	CARD.				apoptosis|regulation of apoptosis	intracellular				NS(1)|breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|liver(2)|lung(29)|ovary(2)|pancreas(1)|prostate(2)|skin(3)|urinary_tract(1)	62						GCTGATTTCTGAGGAAGAGTA	0.408000													5	91					0	0	1	0	0
CYP27B1	1594	broad.mit.edu	37	12	58160754	58160754	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr12:58160754G>C	ENST00000228606.4	-	1	280	c.71C>G	c.(70-72)tCc>tGc	p.S24C	RP11-571M6.13_ENST00000546609.1_RNA	NM_000785.3	NP_000776.1	O15528	CP27B_HUMAN	cytochrome P450, family 27, subfamily B, polypeptide 1	24					bone mineralization|calcium ion homeostasis|calcium ion transport|decidualization|G1 to G0 transition|hormone biosynthetic process|negative regulation of calcidiol 1-monooxygenase activity|negative regulation of cell growth|negative regulation of cell proliferation|positive regulation of keratinocyte differentiation|positive regulation of vitamin D 24-hydroxylase activity|positive regulation of vitamin D receptor signaling pathway|regulation of bone mineralization|response to estrogen stimulus|response to interferon-gamma|response to lipopolysaccharide|response to tumor necrosis factor|response to vitamin D|vitamin D biosynthetic process|xenobiotic metabolic process	mitochondrial outer membrane	calcidiol 1-monooxygenase activity|electron carrier activity|heme binding			central_nervous_system(3)|endometrium(1)|kidney(1)|large_intestine(3)|lung(5)|prostate(1)|urinary_tract(1)	15	all_cancers(7;8.09e-80)|Lung NSC(6;2.26e-27)|all_lung(6;1.99e-25)|all_epithelial(6;3.62e-18)|Glioma(12;6.95e-05)|all_neural(12;0.00016)|Melanoma(17;0.122)		GBM - Glioblastoma multiforme(5;1.97e-113)|all cancers(5;1.54e-78)|BRCA - Breast invasive adenocarcinoma(9;0.0294)		Calcidiol(DB00146)|Calcitriol(DB00136)|Ergocalciferol(DB00153)	GTAGCCTAGGGAGGCGCCCAA	0.632000													12	204					0	0	1	0	0
CAPS2	84698	broad.mit.edu	37	12	75693620	75693620	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr12:75693620G>A	ENST00000393284.3	-	9	813	c.212C>T	c.(211-213)tCa>tTa	p.S71L	CAPS2_ENST00000409004.1_5'UTR|CAPS2_ENST00000442339.2_Intron|CAPS2_ENST00000409799.1_Missense_Mutation_p.S253L|CAPS2_ENST00000409445.3_Missense_Mutation_p.S303L			Q9BXY5	CAYP2_HUMAN	calcyphosine 2	303							calcium ion binding			endometrium(2)|large_intestine(1)|lung(4)|ovary(2)|skin(1)	10						CAATTACCGTGATACGATCCT	0.264000													6	189					0	0	1	0	0
HAVCR2	84868	broad.mit.edu	37	5	156533768	156533768	+	Silent	SNP	G	G	A			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr5:156533768G>A	ENST00000307851.4	-	2	994	c.264C>T	c.(262-264)ttC>ttT	p.F88F	CTB-120L21.1_ENST00000517708.1_RNA|HAVCR2_ENST00000522593.1_Silent_p.F88F|HAVCR2_ENST00000517358.1_5'UTR	NM_032782.4	NP_116171.3	Q8TDQ0	HAVR2_HUMAN	hepatitis A virus cellular receptor 2	88	Ig-like V-type.					integral to membrane				cervix(1)|large_intestine(4)|lung(12)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	22	Renal(175;0.00212)	Medulloblastoma(196;0.0354)|all_neural(177;0.0999)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			CTCCTTTGCGGAAATCCCCAT	0.473000													13	132					0	0	1	0	0
MYH2	4620	broad.mit.edu	37	17	10428364	10428364	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr17:10428364C>T	ENST00000245503.5	-	34	5065	c.4681G>A	c.(4681-4683)Gag>Aag	p.E1561K	CTC-297N7.7_ENST00000399342.2_RNA|MYH2_ENST00000397183.2_Missense_Mutation_p.E1561K|CTC-297N7.7_ENST00000587182.1_RNA|MYH2_ENST00000532183.1_Intron|CTC-297N7.7_ENST00000581304.1_RNA	NM_017534.5	NP_060004.3	Q9UKX2	MYH2_HUMAN	myosin, heavy chain 2, skeletal muscle, adult	1561					muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(16)|lung(99)|ovary(6)|pancreas(4)|prostate(3)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(4)	176						ATCTTTCCCTCTTCATGTTCA	0.408000													15	215					0	0	1	0	0
ADNP2	22850	broad.mit.edu	37	18	77895633	77895633	+	Silent	SNP	C	C	T			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr18:77895633C>T	ENST00000262198.4	+	4	2792	c.2337C>T	c.(2335-2337)ttC>ttT	p.F779F		NM_014913.3	NP_055728.1	Q6IQ32	ADNP2_HUMAN	ADNP homeobox 2	779					cellular response to oxidative stress|cellular response to retinoic acid|negative regulation of cell death|neuron differentiation|positive regulation of cell growth	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(3)|large_intestine(9)|liver(1)|lung(15)|ovary(5)|prostate(2)	42		all_cancers(4;1.06e-15)|all_epithelial(4;2.36e-10)|all_lung(4;0.000302)|Lung NSC(4;0.000518)|Esophageal squamous(42;0.0212)|Ovarian(4;0.0256)|all_hematologic(56;0.15)|Melanoma(33;0.2)		Epithelial(2;1.1e-11)|OV - Ovarian serous cystadenocarcinoma(15;7.54e-09)|BRCA - Breast invasive adenocarcinoma(31;0.00247)|STAD - Stomach adenocarcinoma(84;0.164)		CATGCACCTTCCATGATATCA	0.473000													11	150					0	0	1	0	0
PFKM	5213	broad.mit.edu	37	12	48535527	48535527	+	Silent	SNP	C	C	T			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr12:48535527C>T	ENST00000340802.6	+	18	1854	c.1630C>T	c.(1630-1632)Cta>Tta	p.L544L	PFKM_ENST00000551804.1_Silent_p.L442L|PFKM_ENST00000547587.1_Silent_p.L473L|PFKM_ENST00000395233.2_Silent_p.L442L|PFKM_ENST00000359794.5_Silent_p.L473L|PFKM_ENST00000312352.7_Silent_p.L473L	NM_001166686.1	NP_001160158.1	P08237	K6PF_HUMAN	phosphofructokinase, muscle	473					fructose 6-phosphate metabolic process|glycolysis|muscle cell homeostasis	6-phosphofructokinase complex|apical plasma membrane	6-phosphofructokinase activity|ATP binding|identical protein binding|kinase binding|metal ion binding|protein C-terminus binding			NS(3)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(16)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	35						AACTAGGACTCTACCCAAGAA	0.483000													12	185					0	0	1	0	0
MAGI3	260425	broad.mit.edu	37	1	114196526	114196526	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr1:114196526G>C	ENST00000369615.1	+	15	2577	c.2515G>C	c.(2515-2517)Gag>Cag	p.E839Q	MAGI3_ENST00000369611.4_Missense_Mutation_p.E839Q|MAGI3_ENST00000307546.9_Missense_Mutation_p.E839Q|MAGI3_ENST00000369617.4_Missense_Mutation_p.E864Q	NM_152900.2	NP_690864.2	Q5TCQ9	MAGI3_HUMAN	membrane associated guanylate kinase, WW and PDZ domain containing 3	864					apoptosis|interspecies interaction between organisms|intracellular signal transduction	nucleus|tight junction	ATP binding|guanylate kinase activity|protein binding			NS(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(8)|lung(9)|ovary(3)|prostate(7)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	41	Lung SC(450;0.184)	all_cancers(81;2.34e-09)|all_epithelial(167;7.41e-09)|all_lung(203;7.13e-06)|Lung NSC(69;1.2e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		GAACCGGGCAGAGGTCCCAGC	0.483000													20	310					0	0	1	0	0
LINC00969	440993	broad.mit.edu	37	3	195400728	195400728	+	RNA	SNP	A	A	G	rs12107841	by1000genomes	TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr3:195400728A>G	ENST00000445430.1	+	0	1324																											GATTGTGCCCAGCCTGTACGC	0.587000													5	28					0	0	1	0	0
SIRT5	23408	broad.mit.edu	37	6	13584426	13584426	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr6:13584426G>C	ENST00000606117.1	+	3	380	c.84G>C	c.(82-84)caG>caC	p.Q28H	SIRT5_ENST00000379262.4_Missense_Mutation_p.Q28H|SIRT5_ENST00000359782.3_Missense_Mutation_p.Q28H|SIRT5_ENST00000397350.2_5'UTR	NM_012241.4	NP_036373.1	Q9NXA8	SIRT5_HUMAN	sirtuin 5	28					chromatin silencing|protein ADP-ribosylation|protein deacetylation	mitochondrial intermembrane space|mitochondrial matrix	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides|NAD+ ADP-ribosyltransferase activity|NAD+ binding|zinc ion binding			breast(1)|endometrium(1)|large_intestine(3)|lung(1)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)	11	Breast(50;0.00669)|Ovarian(93;0.0634)	all_hematologic(90;0.117)	Epithelial(50;0.176)		Suramin(DB04786)	CACGAAACCAGATTTGCCTGA	0.483000													6	89					0	0	1	0	0
GRIP1	23426	broad.mit.edu	37	12	66773095	66773095	+	Silent	SNP	C	C	G			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr12:66773095C>G	ENST00000359742.4	-	20	2826	c.2586G>C	c.(2584-2586)ctG>ctC	p.L862L	GRIP1_ENST00000286445.7_Silent_p.L862L|GRIP1_ENST00000398016.3_Silent_p.L810L			Q9Y3R0	GRIP1_HUMAN	glutamate receptor interacting protein 1	862					androgen receptor signaling pathway|intracellular signal transduction|positive regulation of transcription, DNA-dependent|synaptic transmission	cell junction|cytoplasmic membrane-bounded vesicle|cytosol|endoplasmic reticulum|postsynaptic membrane	androgen receptor binding|beta-catenin binding|protein C-terminus binding|receptor signaling complex scaffold activity|transcription coactivator activity			NS(3)|breast(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(10)|lung(19)|ovary(2)|prostate(2)|skin(1)	50			GBM - Glioblastoma multiforme(2;0.00069)	GBM - Glioblastoma multiforme(28;0.0933)		CTTCATAACTCAGCCCCACAT	0.502000													8	231					0	0	1	0	0
GALC	2581	broad.mit.edu	37	14	88429749	88429749	+	Silent	SNP	G	G	A			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr14:88429749G>A	ENST00000261304.2	-	10	1246	c.1140C>T	c.(1138-1140)ctC>ctT	p.L380L	GALC_ENST00000393569.2_Silent_p.L354L|GALC_ENST00000393568.4_Silent_p.L357L|GALC_ENST00000544807.2_Silent_p.L324L	NM_000153.3|NM_001201401.1	NP_000144.2|NP_001188330.1	P54803	GALC_HUMAN	galactosylceramidase	380					carbohydrate metabolic process|galactosylceramide catabolic process	lysosome	cation binding|galactosylceramidase activity			endometrium(2)|kidney(2)|large_intestine(1)|lung(10)|ovary(1)|prostate(1)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	21						TGATGATGGTGAGGTTCCCTA	0.378000													5	100					0	0	1	0	0
SMYD2	56950	broad.mit.edu	37	1	214488132	214488132	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr1:214488132G>A	ENST00000366957.5	+	3	287	c.265G>A	c.(265-267)Gaa>Aaa	p.E89K	SMYD2_ENST00000415093.2_Missense_Mutation_p.E89K|SMYD2_ENST00000491455.1_3'UTR	NM_020197.2	NP_064582.2	Q9NRG4	SMYD2_HUMAN	SET and MYND domain containing 2	89					negative regulation of cell proliferation|negative regulation of transcription from RNA polymerase II promoter|peptidyl-lysine dimethylation|peptidyl-lysine monomethylation|regulation of DNA damage response, signal transduction by p53 class mediator|transcription, DNA-dependent	cytosol|nucleus	histone methyltransferase activity (H3-K36 specific)|p53 binding|RNA polymerase II core binding|zinc ion binding			breast(2)|endometrium(3)|kidney(1)|large_intestine(1)|lung(5)|ovary(1)|upper_aerodigestive_tract(1)	14				OV - Ovarian serous cystadenocarcinoma(81;0.0122)|all cancers(67;0.0209)|GBM - Glioblastoma multiforme(131;0.106)|Epithelial(68;0.144)		GCACAAGCTGGAATGTTCTCC	0.423000													4	105					0	0	1	0	0
FRYL	285527	broad.mit.edu	37	4	48502084	48502084	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr4:48502084C>G	ENST00000358350.4	-	63	9350	c.8746G>C	c.(8746-8748)Gaa>Caa	p.E2916Q	FRYL_ENST00000507873.2_Missense_Mutation_p.E306Q|FRYL_ENST00000264319.7_Missense_Mutation_p.E306Q|FRYL_ENST00000537810.1_Missense_Mutation_p.E2916Q|FRYL_ENST00000503238.1_Missense_Mutation_p.E2916Q	NM_015030.1	NP_055845.1	O94915	FRYL_HUMAN	FRY-like	2916					regulation of transcription, DNA-dependent|transcription, DNA-dependent		protein binding	p.E2916*(1)		breast(2)|central_nervous_system(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(21)|lung(38)|ovary(1)|pancreas(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	91						GATATAAATTCTTTATTTTTC	0.343000													4	69					0	0	1	0	0
CNTN6	27255	broad.mit.edu	37	3	1262490	1262490	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr3:1262490C>T	ENST00000446702.2	+	3	802	c.175C>T	c.(175-177)Cat>Tat	p.H59Y	CNTN6_ENST00000350110.2_Missense_Mutation_p.H59Y|CNTN6_ENST00000539053.1_5'UTR			Q9UQ52	CNTN6_HUMAN	contactin 6	59	Ig-like C2-type 1.				axon guidance|cell adhesion|central nervous system development|Notch signaling pathway	anchored to membrane|plasma membrane				breast(6)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(25)|lung(34)|ovary(1)|pancreas(1)|prostate(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	90		all_cancers(2;0.000164)|all_epithelial(2;0.107)		Epithelial(13;0.000233)|all cancers(10;0.0013)|OV - Ovarian serous cystadenocarcinoma(96;0.0139)		CCCTTCGCCTCATTATAGGTA	0.363000													8	129					0	0	1	0	0
RBAK	57786	broad.mit.edu	37	7	5104496	5104496	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr7:5104496C>T	ENST00000396912.1	+	5	1928	c.1409C>T	c.(1408-1410)tCa>tTa	p.S470L	RBAK_ENST00000407184.1_Intron|RBAK_ENST00000353796.3_Missense_Mutation_p.S470L|RBAK_ENST00000396904.2_Intron	NM_021163.3	NP_066986.1	Q9NYW8	RBAK_HUMAN	RB-associated KRAB zinc finger	470	Interaction with AR.				negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			NS(1)|kidney(1)|large_intestine(2)|ovary(4)|skin(1)|upper_aerodigestive_tract(1)	10		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0916)|OV - Ovarian serous cystadenocarcinoma(56;2.44e-14)		AATTTAAATTCAGCCTTCATT	0.368000													8	101					0	0	1	0	0
MMP27	64066	broad.mit.edu	37	11	102564686	102564686	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr11:102564686C>T	ENST00000260229.4	-	8	1235	c.1144G>A	c.(1144-1146)Gat>Aat	p.D382N		NM_022122.2	NP_071405.2	Q9H306	MMP27_HUMAN	matrix metallopeptidase 27	382	Hemopexin-like 3.				collagen catabolic process|proteolysis	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(4)|liver(2)|lung(12)|ovary(2)|prostate(2)|skin(11)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	45	all_cancers(8;0.000843)|all_epithelial(12;0.00362)|Lung NSC(15;0.21)	all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)	Epithelial(9;0.0509)|Lung(13;0.0696)|LUSC - Lung squamous cell carcinoma(19;0.13)|all cancers(10;0.176)	BRCA - Breast invasive adenocarcinoma(274;0.0151)		GTGGTCTTATCACAGACGGCT	0.393000													13	158					0	0	1	0	0
RNF168	165918	broad.mit.edu	37	3	196210708	196210708	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr3:196210708C>T	ENST00000318037.3	-	4	1207	c.613G>A	c.(613-615)Gat>Aat	p.D205N		NM_152617.3	NP_689830.2	Q8IYW5	RN168_HUMAN	ring finger protein 168, E3 ubiquitin protein ligase	205					double-strand break repair|histone H2A K63-linked ubiquitination|positive regulation of DNA repair|response to ionizing radiation	nucleus|ubiquitin ligase complex	chromatin binding|histone binding|ubiquitin binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|endometrium(2)|large_intestine(7)|lung(9)|ovary(1)	20	all_cancers(143;1e-08)|Ovarian(172;0.0634)|Breast(254;0.206)		Epithelial(36;5.25e-24)|all cancers(36;5.47e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.76e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00348)		GTAACTGGATCAGATTTTCTG	0.348000													6	213					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9009320	9009320	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr19:9009320G>C	ENST00000397910.4	-	40	39356	c.39153C>G	c.(39151-39153)ttC>ttG	p.F13051L		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	13053	SEA 7.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TGGAGTTCTTGAACAAGGGAC	0.532000													10	115					0	0	1	0	0
CHUK	1147	broad.mit.edu	37	10	101969423	101969423	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr10:101969423C>T	ENST00000370397.7	-	10	1143	c.1057G>A	c.(1057-1059)Gaa>Aaa	p.E353K		NM_001278.3	NP_001269.3	O15111	IKKA_HUMAN	conserved helix-loop-helix ubiquitous kinase	353					I-kappaB phosphorylation|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	CD40 receptor complex|cytosol|internal side of plasma membrane|nucleus	ATP binding|identical protein binding|IkappaB kinase activity			breast(1)|central_nervous_system(2)|endometrium(2)|large_intestine(9)|lung(8)|ovary(2)|prostate(1)|skin(1)|stomach(1)	27		Colorectal(252;0.117)		Epithelial(162;2.05e-10)|all cancers(201;1.91e-08)		GAAAGAAGTTCTTGAGAACCA	0.368000													5	83					0	0	1	0	0
STAG3L4	64940	broad.mit.edu	37	7	66771028	66771028	+	RNA	SNP	C	C	T			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr7:66771028C>T	ENST00000416602.2	+	0	320					NR_040586.1		Q8TBR4	STG34_HUMAN												endometrium(2)|lung(5)	7		Lung NSC(55;0.0839)|all_lung(88;0.181)				TGCAGGATTTCTGGAGCTTGT	0.393000													5	193					0	0	1	0	0
RGS12	6002	broad.mit.edu	37	4	3424646	3424646	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr4:3424646C>G	ENST00000336727.3	+	12	3952	c.3048C>G	c.(3046-3048)caC>caG	p.H1016Q	RGS12_ENST00000306648.7_Missense_Mutation_p.H414Q|RGS12_ENST00000538395.1_Missense_Mutation_p.H358Q|RGS12_ENST00000508158.1_3'UTR|RGS12_ENST00000382788.3_Missense_Mutation_p.H1016Q|RGS12_ENST00000344733.5_Missense_Mutation_p.H1016Q|RGS12_ENST00000338806.4_Missense_Mutation_p.H368Q	NM_002926.3	NP_002917.1	O14924	RGS12_HUMAN	regulator of G-protein signaling 12	1016	RBD 1.					condensed nuclear chromosome|cytoplasm|plasma membrane	GTPase activator activity|receptor signaling protein activity			autonomic_ganglia(1)|breast(4)|endometrium(3)|kidney(2)|large_intestine(9)|lung(16)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	43				UCEC - Uterine corpus endometrioid carcinoma (64;0.168)		TGGTGCTGCACCAAGACAGTA	0.582000													9	109					0	0	1	0	0
FAM71B	153745	broad.mit.edu	37	5	156589669	156589669	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr5:156589669G>C	ENST00000302938.4	-	2	1702	c.1607C>G	c.(1606-1608)tCt>tGt	p.S536C		NM_130899.2	NP_570969.2	Q8TC56	FA71B_HUMAN	family with sequence similarity 71, member B	536						nucleus				NS(3)|breast(1)|central_nervous_system(3)|cervix(1)|endometrium(2)|kidney(5)|large_intestine(10)|lung(32)|ovary(4)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	68	Renal(175;0.00212)	Medulloblastoma(196;0.0523)|all_neural(177;0.21)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			CCTTAAAAAAGAGCTGATCTT	0.463000													4	93					0	0	1	0	0
HERPUD1	9709	broad.mit.edu	37	16	56973985	56973985	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr16:56973985C>T	ENST00000439977.2	+	6	930	c.733C>T	c.(733-735)Cgg>Tgg	p.R245W	HERPUD1_ENST00000570273.1_3'UTR|HERPUD1_ENST00000344114.4_Intron|HERPUD1_ENST00000300302.5_Missense_Mutation_p.R244W|HERPUD1_ENST00000379792.2_Missense_Mutation_p.R220W	NM_001010989.1|NM_014685.2	NP_001010989.1|NP_055500.1	Q15011	HERP1_HUMAN	homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1	245						endoplasmic reticulum membrane|integral to membrane	protein binding			cervix(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(4)|prostate(1)|stomach(1)	11						TCAAAATTTGCGGATGAATGC	0.438000			T	ERG	prostate								4	107					0	0	1	0	0
STK17B	9262	broad.mit.edu	37	2	197008314	197008314	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr2:197008314G>A	ENST00000263955.4	-	5	863	c.577C>T	c.(577-579)Cgg>Tgg	p.R193W	STK17B_ENST00000409228.1_Missense_Mutation_p.R193W	NM_004226.3	NP_004217.1	O94768	ST17B_HUMAN	serine/threonine kinase 17b	193	Protein kinase.				apoptosis|induction of apoptosis|intracellular protein kinase cascade	nucleus	ATP binding|protein serine/threonine kinase activity			breast(1)|cervix(1)|kidney(2)|large_intestine(1)|lung(10)	15			OV - Ovarian serous cystadenocarcinoma(117;0.141)			ATGATTTCCCGAAGTTCACAC	0.338000													7	121					0	0	1	0	0
OLFML2A	169611	broad.mit.edu	37	9	127549484	127549484	+	Silent	SNP	G	G	A			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr9:127549484G>A	ENST00000373580.3	+	2	321	c.321G>A	c.(319-321)gaG>gaA	p.E107E		NM_182487.2	NP_872293.2	Q68BL7	OLM2A_HUMAN	olfactomedin-like 2A	107										endometrium(5)|kidney(1)|large_intestine(8)|lung(8)|ovary(2)|upper_aerodigestive_tract(1)	25						GGAAGATGGAGAAACTCAAAA	0.587000													5	49					0	0	1	0	0
KIAA1432	57589	broad.mit.edu	37	9	5763450	5763450	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr9:5763450G>A	ENST00000414202.2	+	19	2614	c.2423G>A	c.(2422-2424)aGa>aAa	p.R808K	KIAA1432_ENST00000418622.3_Missense_Mutation_p.R729K|KIAA1432_ENST00000251879.6_Missense_Mutation_p.R808K|KIAA1432_ENST00000449720.2_Missense_Mutation_p.R692K|KIAA1432_ENST00000381532.2_Missense_Mutation_p.R729K	NM_001206557.1|NM_020829.3	NP_001193486.1|NP_065880.2	Q4ADV7	RIC1_HUMAN	KIAA1432	808						integral to membrane				breast(2)|cervix(2)|endometrium(6)|kidney(4)|large_intestine(6)|lung(23)|prostate(1)|upper_aerodigestive_tract(1)	45		Acute lymphoblastic leukemia(23;0.154)		GBM - Glioblastoma multiforme(50;0.000525)|Lung(218;0.122)		AACAATGCTAGAGAACAGCTG	0.448000													15	189					0	0	1	0	0
IRX6	79190	broad.mit.edu	37	16	55359008	55359008	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr16:55359008C>G	ENST00000290552.7	+	1	1337	c.5C>G	c.(4-6)tCc>tGc	p.S2C	RP11-26L20.3_ENST00000558730.2_RNA	NM_024335.2	NP_077311.2	P78412	IRX6_HUMAN	iroquois homeobox 6	2						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|central_nervous_system(5)|endometrium(3)|kidney(2)|large_intestine(6)|liver(2)|lung(10)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	33						GCCACCATGTCCTTCCCACAC	0.627000													4	42					0	0	1	0	0
WDR45	11152	broad.mit.edu	37	X	48934116	48934116	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chrX:48934116C>G	ENST00000356463.3	-	7	850	c.412G>C	c.(412-414)Gag>Cag	p.E138Q	WDR45_ENST00000322995.8_Missense_Mutation_p.E137Q|WDR45_ENST00000553851.1_Intron|WDR45_ENST00000396681.4_Missense_Mutation_p.E137Q|WDR45_ENST00000376358.3_Intron|WDR45_ENST00000376368.2_Missense_Mutation_p.E138Q|WDR45_ENST00000376372.3_Missense_Mutation_p.E137Q|WDR45_ENST00000470270.1_5'UTR|WDR45_ENST00000485908.1_Missense_Mutation_p.E102Q|WDR45_ENST00000473974.1_Missense_Mutation_p.E137Q	NM_007075.3	NP_009006.2	Q9Y484	WIPI4_HUMAN	WD repeat domain 45	137					autophagy|response to starvation	organelle membrane	phosphatidylinositol-3,5-bisphosphate binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(7)|ovary(1)|skin(1)	19						GTATCAAACTCAAACAGCTTT	0.537000													7	87					0	0	1	0	0
DHX9	1660	broad.mit.edu	37	1	182836128	182836128	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr1:182836128C>T	ENST00000367549.3	+	14	1617	c.1507C>T	c.(1507-1509)Cga>Tga	p.R503*		NM_001357.4	NP_001348.2	Q08211	DHX9_HUMAN	DEAH (Asp-Glu-Ala-His) box helicase 9	503	Helicase ATP-binding.				CRD-mediated mRNA stabilization|nuclear mRNA splicing, via spliceosome	centrosome|CRD-mediated mRNA stability complex|nucleolus|nucleoplasm|ribonucleoprotein complex	ATP binding|ATP-dependent DNA helicase activity|ATP-dependent RNA helicase activity|DNA binding|double-stranded RNA binding|protein binding			NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(10)|kidney(3)|large_intestine(7)|liver(1)|lung(19)|ovary(2)|prostate(1)|skin(1)|urinary_tract(2)	49						AGCAGGCATTCGAGGAATCAG	0.308000													6	156					0	0	1	0	0
ZFYVE1	53349	broad.mit.edu	37	14	73437692	73437692	+	Silent	SNP	G	G	A			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr14:73437692G>A	ENST00000556143.1	-	12	2952	c.2232C>T	c.(2230-2232)ttC>ttT	p.F744F	ZFYVE1_ENST00000394207.2_Silent_p.F329F|ZFYVE1_ENST00000553891.1_Silent_p.F744F|ZFYVE1_ENST00000318876.5_Silent_p.F730F|ZFYVE1_ENST00000555072.1_Silent_p.F329F	NM_021260.2	NP_067083.1	Q9HBF4	ZFYV1_HUMAN	zinc finger, FYVE domain containing 1	744						endoplasmic reticulum|Golgi stack|perinuclear region of cytoplasm	1-phosphatidylinositol binding|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(6)|lung(17)|ovary(1)|prostate(2)|skin(1)	35		all_lung(585;1.33e-09)		OV - Ovarian serous cystadenocarcinoma(108;1.6e-46)|BRCA - Breast invasive adenocarcinoma(234;0.00349)		ACTCATCACAGAAGCCCTGTC	0.592000													11	94					0	0	1	0	0
PIK3C2A	5286	broad.mit.edu	37	11	17139073	17139073	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr11:17139073C>G	ENST00000265970.7	-	18	3180	c.3181G>C	c.(3181-3183)Gaa>Caa	p.E1061Q	PIK3C2A_ENST00000540361.1_Missense_Mutation_p.E681Q|PIK3C2A_ENST00000531428.1_Intron	NM_002645.2	NP_002636.2	O00443	P3C2A_HUMAN	phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha	1061					cell communication|phosphatidylinositol biosynthetic process|phosphatidylinositol-mediated signaling	clathrin-coated vesicle|Golgi apparatus|nucleus|phosphatidylinositol 3-kinase complex|plasma membrane	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity			central_nervous_system(4)|endometrium(5)|kidney(5)|large_intestine(7)|lung(24)|ovary(3)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	58					Phosphatidylserine(DB00144)	CTTACTTTTTCTGCTACTCCT	0.408000													7	156					0	0	1	0	0
TLR2	7097	broad.mit.edu	37	4	154626061	154626061	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr4:154626061C>G	ENST00000260010.6	+	1	3410	c.2002C>G	c.(2002-2004)Ccc>Gcc	p.P668A		NM_003264.3	NP_003255.2	O60603	TLR2_HUMAN	toll-like receptor 2	668	TIR.				cellular response to diacyl bacterial lipopeptide|cellular response to lipoteichoic acid|cellular response to triacyl bacterial lipopeptide|detection of diacyl bacterial lipopeptide|detection of triacyl bacterial lipopeptide|I-kappaB phosphorylation|induction of apoptosis|inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway|positive regulation of chemokine production|positive regulation of interferon-beta production|positive regulation of interleukin-12 production|positive regulation of interleukin-18 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of toll-like receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|positive regulation of Wnt receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	cytoplasm|integral to plasma membrane|Toll-like receptor 1-Toll-like receptor 2 protein complex	Gram-positive bacterial cell surface binding|lipopolysaccharide receptor activity|peptidoglycan binding|protein heterodimerization activity|transmembrane receptor activity|triacyl lipopeptide binding			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(6)|lung(11)|ovary(1)|pancreas(1)|skin(1)|urinary_tract(1)	29	all_hematologic(180;0.093)	Renal(120;0.117)				GAACTTCAATCCCCCCTTCAA	0.463000													4	139					0	0	1	0	0
RFWD2	64326	broad.mit.edu	37	1	176012350	176012350	+	Silent	SNP	G	G	C			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr1:176012350G>C	ENST00000367669.3	-	14	2098	c.1584C>G	c.(1582-1584)ctC>ctG	p.L528L	RFWD2_ENST00000308769.8_Silent_p.L504L	NM_022457.5	NP_071902.2	Q8NHY2	RFWD2_HUMAN	ring finger and WD repeat domain 2, E3 ubiquitin protein ligase	528					DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	centrosome|cytosol|focal adhesion|nuclear speck	protein binding|ubiquitin-protein ligase activity|zinc ion binding			endometrium(1)|kidney(2)|large_intestine(5)|lung(17)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	30						CTGAAGCCAAGAGTTTAGGAT	0.438000													5	172					0	0	1	0	0
SF3B1	23451	broad.mit.edu	37	2	198260841	198260841	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr2:198260841C>T	ENST00000335508.5	-	23	3569	c.3478G>A	c.(3478-3480)Gaa>Aaa	p.E1160K		NM_012433.2	NP_036565.2	O75533	SF3B1_HUMAN	splicing factor 3b, subunit 1, 155kDa	1160					nuclear mRNA splicing, via spliceosome	catalytic step 2 spliceosome|nuclear speck|U12-type spliceosomal complex	protein binding			NS(35)|breast(10)|central_nervous_system(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(524)|kidney(4)|large_intestine(10)|lung(19)|ovary(1)|pancreas(4)|prostate(6)|salivary_gland(1)|skin(4)|testis(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	633			OV - Ovarian serous cystadenocarcinoma(117;0.246)			TTTCCCATTTCACCAATATAT	0.333000			Mis		myelodysplastic syndrome								12	155					0	0	1	0	0
DHX9	1660	broad.mit.edu	37	1	182856289	182856289	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr1:182856289C>G	ENST00000367549.3	+	28	3643	c.3533C>G	c.(3532-3534)tCt>tGt	p.S1178C	DHX9_ENST00000485081.1_3'UTR	NM_001357.4	NP_001348.2	Q08211	DHX9_HUMAN	DEAH (Asp-Glu-Ala-His) box helicase 9	1178	NTD.				CRD-mediated mRNA stabilization|nuclear mRNA splicing, via spliceosome	centrosome|CRD-mediated mRNA stability complex|nucleolus|nucleoplasm|ribonucleoprotein complex	ATP binding|ATP-dependent DNA helicase activity|ATP-dependent RNA helicase activity|DNA binding|double-stranded RNA binding|protein binding	p.S1178F(1)		NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(10)|kidney(3)|large_intestine(7)|liver(1)|lung(19)|ovary(2)|prostate(1)|skin(1)|urinary_tract(2)	49						AGGGGAGGTTCTAGTTACAGT	0.532000													6	131					0	0	1	0	0
ZNF441	126068	broad.mit.edu	37	19	11891591	11891591	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr19:11891591C>T	ENST00000357901.4	+	4	1054	c.952C>T	c.(952-954)Ctt>Ttt	p.L318F	ZNF441_ENST00000454339.2_Missense_Mutation_p.L251F	NM_152355.2	NP_689568.2	Q8N8Z8	ZN441_HUMAN	zinc finger protein 441	318					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|kidney(1)|large_intestine(3)|lung(7)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	19						AAAAGGCTTTCTTTCTCCCAG	0.398000													6	169					0	0	1	0	0
SLC15A2	6565	broad.mit.edu	37	3	121647331	121647331	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr3:121647331G>A	ENST00000489711.1	+	15	1658	c.1270G>A	c.(1270-1272)Gat>Aat	p.D424N	SLC15A2_ENST00000295605.2_Missense_Mutation_p.D393N|SLC15A2_ENST00000465060.1_3'UTR	NM_021082.3	NP_066568.3	Q16348	S15A2_HUMAN	solute carrier family 15 (oligopeptide transporter), member 2	424					protein transport	integral to plasma membrane	peptide:hydrogen symporter activity|protein binding			NS(1)|endometrium(1)|kidney(4)|large_intestine(5)|lung(17)|skin(6)|upper_aerodigestive_tract(2)	36				GBM - Glioblastoma multiforme(114;0.0967)	Cefadroxil(DB01140)	TCTGGCAGATGATGAGGTGAA	0.448000													13	178					0	0	1	0	0
IL17RA	23765	broad.mit.edu	37	22	17589873	17589873	+	Silent	SNP	G	G	A			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr22:17589873G>A	ENST00000319363.6	+	13	1897	c.1764G>A	c.(1762-1764)gaG>gaA	p.E588E		NM_014339.5	NP_055154.3	Q96F46	I17RA_HUMAN	interleukin 17 receptor A	588					fibroblast activation|positive regulation of interleukin-23 production	integral to plasma membrane	interleukin-17 receptor activity			endometrium(2)|large_intestine(8)|lung(16)|ovary(1)|skin(2)|stomach(1)	30		all_epithelial(15;0.0181)|Lung NSC(13;0.109)|all_lung(157;0.132)		Colorectal(9;0.241)		TCGAATGTGAGAACCTCTACT	0.667000													4	22					0	0	1	0	0
PEG3	5178	broad.mit.edu	37	19	57327616	57327616	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr19:57327616G>C	ENST00000326441.9	-	10	2557	c.2194C>G	c.(2194-2196)Cag>Gag	p.Q732E	PEG3_ENST00000423103.2_Missense_Mutation_p.Q732E|ZIM2_ENST00000391708.3_Intron|ZIM2_ENST00000599935.1_Intron|ZIM2_ENST00000221722.5_Intron|PEG3_ENST00000593695.1_Missense_Mutation_p.Q606E|ZIM2_ENST00000601070.1_Intron|ZIM2_ENST00000593711.1_Intron|PEG3_ENST00000598410.1_Missense_Mutation_p.Q608E	NM_006210.2	NP_006201.1	Q9GZU2	PEG3_HUMAN	paternally expressed 3	732					apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|biliary_tract(4)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(27)|lung(84)|ovary(8)|pancreas(5)|prostate(6)|skin(8)|stomach(2)|upper_aerodigestive_tract(6)	170		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)		TGACTCTTCTGAGATTCAGTG	0.418000													9	164					0	0	1	0	0
ANK1	286	broad.mit.edu	37	8	41559121	41559121	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr8:41559121C>G	ENST00000396942.1	-	22	2491	c.2408G>C	c.(2407-2409)cGa>cCa	p.R803P	ANK1_ENST00000379758.2_Missense_Mutation_p.R803P|ANK1_ENST00000347528.4_Missense_Mutation_p.R803P|ANK1_ENST00000396945.1_Missense_Mutation_p.R803P|ANK1_ENST00000265709.8_Missense_Mutation_p.R836P|ANK1_ENST00000289734.7_Missense_Mutation_p.R803P|ANK1_ENST00000352337.4_Missense_Mutation_p.R803P			P16157	ANK1_HUMAN	ankyrin 1, erythrocytic	803	89 kDa domain.				axon guidance|cytoskeleton organization|exocytosis|maintenance of epithelial cell apical/basal polarity|signal transduction	basolateral plasma membrane|cytosol|sarcomere|sarcoplasmic reticulum|spectrin-associated cytoskeleton	cytoskeletal adaptor activity|enzyme binding|protein binding|spectrin binding|structural constituent of cytoskeleton	p.R803Q(1)		breast(5)|central_nervous_system(4)|endometrium(9)|kidney(1)|large_intestine(26)|lung(62)|ovary(3)|prostate(5)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	122	Ovarian(28;0.00541)|Colorectal(14;0.0398)|Lung SC(25;0.211)	all_lung(54;0.000626)|Lung NSC(58;0.00245)|Esophageal squamous(32;0.0559)|Hepatocellular(245;0.0663)|Renal(179;0.188)	OV - Ovarian serous cystadenocarcinoma(14;0.000984)|Lung(22;0.00108)|Colorectal(10;0.00245)|LUSC - Lung squamous cell carcinoma(45;0.00392)|COAD - Colon adenocarcinoma(11;0.0264)			GAAACTCATTCGATGCTTATC	0.488000											OREG0018740	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	83					0	0	1	0	0
ZFC3H1	196441	broad.mit.edu	37	12	72057343	72057343	+	Silent	SNP	C	C	T			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr12:72057343C>T	ENST00000378743.3	-	1	406	c.48G>A	c.(46-48)ccG>ccA	p.P16P	ZFC3H1_ENST00000548100.1_Silent_p.P16P|THAP2_ENST00000308086.2_5'UTR|ZFC3H1_ENST00000552037.1_Silent_p.P16P	NM_144982.4	NP_659419.3	O60293	ZC3H1_HUMAN	zinc finger, C3H1-type containing	16					RNA processing	intracellular	metal ion binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(4)|large_intestine(12)|lung(31)|ovary(3)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	69						CTTCTTCCTTCGGCGAGAGGC	0.647000											OREG0021993	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	12	189					0	0	1	0	0
DLL3	10683	broad.mit.edu	37	19	39998560	39998560	+	Silent	SNP	G	G	A			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr19:39998560G>A	ENST00000205143.4	+	8	1771	c.1764G>A	c.(1762-1764)gcG>gcA	p.A588A	DLL3_ENST00000356433.5_Intron	NM_016941.3	NP_058637.1	Q9NYJ7	DLL3_HUMAN	delta-like 3 (Drosophila)	588					Notch signaling pathway|skeletal system development	integral to membrane	Notch binding			breast(1)|central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(4)|lung(7)	19	all_cancers(60;4.04e-06)|all_lung(34;1.77e-07)|Lung NSC(34;2.09e-07)|all_epithelial(25;1.13e-05)|Ovarian(47;0.159)		Epithelial(26;5.89e-26)|all cancers(26;1.96e-23)|LUSC - Lung squamous cell carcinoma(53;0.000657)			GGGAGGTAGCGACGCCCCTTT	0.562000													4	53					0	0	1	0	0
SDAD1P1	157489	broad.mit.edu	37	8	26237440	26237440	+	RNA	SNP	C	C	T			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr8:26237440C>T	ENST00000519902.1	-	0	2508																											CATTCGCCATCGGCATCCTCC	0.473000													5	125					0	0	1	0	0
KDM2B	84678	broad.mit.edu	37	12	121881866	121881866	+	Silent	SNP	C	C	T			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr12:121881866C>T	ENST00000377069.4	-	16	2713	c.2307G>A	c.(2305-2307)ctG>ctA	p.L769L	KDM2B_ENST00000542973.1_Silent_p.L168L|KDM2B_ENST00000536437.1_Intron|KDM2B_ENST00000377071.4_Silent_p.L800L	NM_001005366.1	NP_001005366.1	Q8NHM5	KDM2B_HUMAN	lysine (K)-specific demethylase 2B	800					embryonic camera-type eye morphogenesis|fourth ventricle development|histone H2A monoubiquitination|initiation of neural tube closure|lateral ventricle development|midbrain development|midbrain-hindbrain boundary morphogenesis|negative regulation of neural precursor cell proliferation|negative regulation of neuron apoptosis|negative regulation of transcription from RNA polymerase II promoter|spermatogenesis|third ventricle development|transcription, DNA-dependent	nucleolus	DNA binding|histone demethylase activity (H3-K36 specific)|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|rRNA binding|zinc ion binding			breast(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(8)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	19						GCTTCTTCCTCAGGTGCACGT	0.647000											OREG0022201	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	7	106					0	0	1	0	0
SLCO3A1	28232	broad.mit.edu	37	15	92647588	92647588	+	Silent	SNP	C	C	T			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr15:92647588C>T	ENST00000318445.6	+	4	1039	c.825C>T	c.(823-825)ctC>ctT	p.L275L	SLCO3A1_ENST00000424469.2_Silent_p.L275L|SLCO3A1_ENST00000555549.1_3'UTR	NM_013272.3	NP_037404.2	Q9UIG8	SO3A1_HUMAN	solute carrier organic anion transporter family, member 3A1	275					sodium-independent organic anion transport	integral to membrane|plasma membrane	sodium-independent organic anion transmembrane transporter activity			breast(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(6)|pancreas(1)|prostate(1)|skin(2)	25	Lung NSC(78;0.0158)|all_lung(78;0.0255)		BRCA - Breast invasive adenocarcinoma(143;0.0841)			GTGCCTTACTCTTCTTCTCTT	0.577000													6	132					0	0	1	0	0
PITRM1	10531	broad.mit.edu	37	10	3180435	3180435	+	Silent	SNP	C	C	T			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr10:3180435C>T	ENST00000380989.2	-	26	3053	c.3015G>A	c.(3013-3015)gtG>gtA	p.V1005V	PITRM1_ENST00000380994.1_Silent_p.V562V|PITRM1_ENST00000451104.2_Silent_p.V906V|PITRM1_ENST00000224949.4_Silent_p.V1004V|PITRM1_ENST00000464395.1_5'UTR	NM_001242307.1|NM_014889.3	NP_001229236.1|NP_055704.2	E7ES23	E7ES23_HUMAN	pitrilysin metallopeptidase 1	906					proteolysis		metalloendopeptidase activity|zinc ion binding			breast(2)|cervix(1)|endometrium(2)|kidney(5)|large_intestine(5)|liver(1)|lung(5)|ovary(1)|pancreas(1)|prostate(4)|skin(1)|stomach(2)|urinary_tract(3)	33						ACCTATCGCTCACGGCCAGGA	0.592000													4	47					0	0	1	0	0
HIST1H2BJ	8970	broad.mit.edu	37	6	27100308	27100308	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr6:27100308G>C	ENST00000607124.1	-	1	221	c.222C>G	c.(220-222)atC>atG	p.I74M	HIST1H2BJ_ENST00000339812.2_Missense_Mutation_p.I74M|HIST1H2BJ_ENST00000541790.1_Missense_Mutation_p.I74M			P06899	H2B1J_HUMAN	histone cluster 1, H2bj	74					defense response to bacterium|nucleosome assembly	nucleosome|nucleus	DNA binding			breast(1)|kidney(2)|lung(5)|ovary(1)|prostate(1)	10						CCTCACCTGCGATGCGCTCGA	0.582000													5	196					0	0	1	0	0
MMP8	4317	broad.mit.edu	37	11	102592156	102592156	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr11:102592156C>T	ENST00000236826.3	-	4	696	c.598G>A	c.(598-600)Gaa>Aaa	p.E200K		NM_002424.2	NP_002415.1	P22894	MMP8_HUMAN	matrix metallopeptidase 8 (neutrophil collagenase)	200					collagen catabolic process|proteolysis	extracellular space|proteinaceous extracellular matrix	metalloendopeptidase activity|serine-type endopeptidase activity|zinc ion binding			autonomic_ganglia(1)|breast(3)|kidney(1)|large_intestine(4)|lung(11)|ovary(4)|skin(6)|stomach(1)|urinary_tract(1)	32	all_cancers(8;0.00092)|all_epithelial(12;0.00389)|Lung NSC(15;0.227)	all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)	Epithelial(9;0.0555)|Lung(13;0.0828)|LUSC - Lung squamous cell carcinoma(19;0.151)|all cancers(10;0.189)	BRCA - Breast invasive adenocarcinoma(274;0.0141)		GTCCATGTTTCTTCGGCATCA	0.433000													6	111					0	0	1	0	0
CUL1	8454	broad.mit.edu	37	7	148457442	148457442	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr7:148457442G>A	ENST00000325222.4	+	7	922	c.643G>A	c.(643-645)Gaa>Aaa	p.E215K	CUL1_ENST00000409469.1_Missense_Mutation_p.E215K|CUL1_ENST00000602748.1_Missense_Mutation_p.E215K	NM_003592.2	NP_003583.2	Q13616	CUL1_HUMAN	cullin 1	215					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell cycle arrest|G1/S transition of mitotic cell cycle|induction of apoptosis by intracellular signals|interspecies interaction between organisms|negative regulation of cell proliferation|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein ubiquitination|S phase of mitotic cell cycle|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	cytosol|nucleoplasm|SCF ubiquitin ligase complex	ubiquitin protein ligase binding			breast(2)|central_nervous_system(2)|endometrium(1)|kidney(5)|large_intestine(10)|liver(2)|lung(10)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(4)	40	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00291)			GGGGCTGAATGAAGATGATGC	0.348000													27	111					0	0	1	0	0
TANC1	85461	broad.mit.edu	37	2	160085351	160085351	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr2:160085351G>C	ENST00000263635.6	+	26	4332	c.4095G>C	c.(4093-4095)ttG>ttC	p.L1365F	TANC1_ENST00000454300.1_Missense_Mutation_p.L1259F	NM_001145909.1|NM_033394.2	NP_001139381.1|NP_203752.2	Q9C0D5	TANC1_HUMAN	tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1	1365						cell junction|postsynaptic density|postsynaptic membrane	binding			breast(3)|central_nervous_system(4)|cervix(2)|endometrium(6)|kidney(4)|large_intestine(9)|lung(25)|ovary(7)|pancreas(1)|prostate(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(2)	77						CTCTCGAATTGAAGCCCAAGT	0.468000													17	249					0	0	1	0	0
STXBP5L	9515	broad.mit.edu	37	3	120976074	120976074	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr3:120976074C>T	ENST00000273666.6	+	17	1997	c.1726C>T	c.(1726-1728)Ccg>Tcg	p.P576S	STXBP5L_ENST00000472879.1_Missense_Mutation_p.P576S|STXBP5L_ENST00000492541.1_Missense_Mutation_p.P576S|STXBP5L_ENST00000471454.1_Missense_Mutation_p.P576S|STXBP5L_ENST00000497029.1_Missense_Mutation_p.P576S	NM_014980.2	NP_055795.1	Q9Y2K9	STB5L_HUMAN	syntaxin binding protein 5-like	576					exocytosis|protein transport	cytoplasm|integral to membrane|plasma membrane				NS(1)|breast(3)|endometrium(3)|kidney(3)|large_intestine(12)|lung(28)|ovary(7)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	68				GBM - Glioblastoma multiforme(114;0.0694)		AACAAGTCCTCCGTTTCCAGA	0.388000													7	195					0	0	1	0	0
NABP2	79035	broad.mit.edu	37	12	56619246	56619246	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr12:56619246G>A	ENST00000380198.2	+	2	667	c.169G>A	c.(169-171)Gat>Aat	p.D57N	NABP2_ENST00000341463.5_Missense_Mutation_p.D57N|NABP2_ENST00000267023.4_Missense_Mutation_p.D57N					nucleic acid binding protein 2																		TGTCTGGGACGATGTTGGCAA	0.527000													8	121					0	0	1	0	0
KRT9	3857	broad.mit.edu	37	17	39724518	39724518	+	Silent	SNP	G	G	A	rs145501803	byFrequency	TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr17:39724518G>A	ENST00000246662.4	-	6	1355	c.1290C>T	c.(1288-1290)atC>atT	p.I430I	KRT9_ENST00000588431.1_Silent_p.I197I	NM_000226.3	NP_000217.2	P35527	K1C9_HUMAN	keratin 9	430	Coil 2.|Rod.				intermediate filament organization|skin development		protein binding|structural constituent of cytoskeleton			autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(4)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	25		Breast(137;0.000307)				TCTGGCACTCGATCTCTTGCC	0.542000													5	91					0	0	1	0	0
AKAP9	10142	broad.mit.edu	37	7	91682117	91682117	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr7:91682117G>C	ENST00000359028.2	+	23	5707	c.5482G>C	c.(5482-5484)Gag>Cag	p.E1828Q	AKAP9_ENST00000358100.2_Missense_Mutation_p.E1828Q|AKAP9_ENST00000356239.3_Missense_Mutation_p.E1816Q			Q99996	AKAP9_HUMAN	A kinase (PRKA) anchor protein 9	1828					G2/M transition of mitotic cell cycle|signal transduction|synaptic transmission|transport	centrosome|cytosol|Golgi apparatus	receptor binding			NS(1)|autonomic_ganglia(2)|breast(14)|central_nervous_system(3)|cervix(1)|endometrium(13)|kidney(12)|large_intestine(35)|lung(49)|ovary(8)|prostate(6)|skin(8)|stomach(1)|urinary_tract(2)	155	all_cancers(62;2.46e-09)|all_epithelial(64;4.42e-08)|Breast(17;0.00206)|all_lung(186;0.185)|all_hematologic(106;0.215)|Lung NSC(181;0.249)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)			AAAAGTAACTGAGGAAGGAAC	0.393000			T	BRAF	papillary thyroid								4	65					0	0	1	0	0
SPATA22	84690	broad.mit.edu	37	17	3346491	3346491	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr17:3346491G>C	ENST00000573128.1	-	8	1360	c.877C>G	c.(877-879)Ctg>Gtg	p.L293V	SPATA22_ENST00000575375.1_Missense_Mutation_p.L293V|SPATA22_ENST00000572969.1_Missense_Mutation_p.L293V|SPATA22_ENST00000397168.3_Missense_Mutation_p.L293V|SPATA22_ENST00000268981.5_Intron|SPATA22_ENST00000355380.4_Missense_Mutation_p.L250V|SPATA22_ENST00000541913.1_Missense_Mutation_p.L277V			Q8NHS9	SPT22_HUMAN	spermatogenesis associated 22	293										breast(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(8)|skin(2)	19						ACACAAGGCAGAGTATTTTTC	0.358000													6	57					0	0	1	0	0
CD2BP2	10421	broad.mit.edu	37	16	30364372	30364372	+	Silent	SNP	C	C	T			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr16:30364372C>T	ENST00000305596.3	-	7	1135	c.960G>A	c.(958-960)cgG>cgA	p.R320R	CD2BP2_ENST00000569466.1_Silent_p.R320R	NM_006110.2	NP_006101.1	O95400	CD2B2_HUMAN	CD2 (cytoplasmic tail) binding protein 2	320	GYF.				assembly of spliceosomal tri-snRNP	cytoplasm|nucleoplasm|U5 snRNP	protein binding|ribonucleoprotein binding			breast(1)|large_intestine(4)|lung(8)|ovary(1)|skin(1)	15						GGTCCAGCTTCCGGCAATAAA	0.587000													4	51					0	0	1	0	0
PPARGC1A	10891	broad.mit.edu	37	4	23886407	23886407	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr4:23886407G>A	ENST00000264867.2	-	2	321	c.202C>T	c.(202-204)Cag>Tag	p.Q68*	PPARGC1A_ENST00000507380.1_Nonsense_Mutation_p.Q68*	NM_013261.3	NP_037393.1	Q9UBK2	PRGC1_HUMAN	peroxisome proliferator-activated receptor gamma, coactivator 1 alpha	68					androgen receptor signaling pathway|brown fat cell differentiation|cellular glucose homeostasis|digestion|fatty acid oxidation|gluconeogenesis|mitochondrion organization|mRNA processing|neuron death|positive regulation of fatty acid oxidation|positive regulation of gluconeogenesis|positive regulation of histone acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|protein complex assembly|protein stabilization|response to muscle activity|response to starvation|RNA splicing|temperature homeostasis|transcription initiation from RNA polymerase II promoter	DNA-directed RNA polymerase II, core complex	androgen receptor binding|DNA binding|ligand-dependent nuclear receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|nucleotide binding|RNA binding|RNA polymerase II transcription cofactor activity|transcription factor binding			central_nervous_system(1)|endometrium(7)|kidney(3)|large_intestine(7)|liver(1)|lung(24)|ovary(3)|skin(5)	51		Breast(46;0.0503)				TTGTTGTACTGATTGGATATT	0.393000													6	91					0	0	1	0	0
ABCB4	5244	broad.mit.edu	37	7	87072740	87072740	+	Silent	SNP	C	C	T			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr7:87072740C>T	ENST00000265723.4	-	12	1362	c.1251G>A	c.(1249-1251)ctG>ctA	p.L417L	ABCB4_ENST00000358400.3_Silent_p.L417L|ABCB4_ENST00000359206.3_Silent_p.L417L|ABCB4_ENST00000545634.1_Silent_p.L417L|ABCB4_ENST00000453593.1_Silent_p.L417L	NM_000443.3|NM_018849.2	NP_000434.1|NP_061337.1	P21439	MDR3_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 4	417	ABC transporter 1.				cellular lipid metabolic process	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus|membrane fraction	ATP binding|xenobiotic-transporting ATPase activity			breast(5)|endometrium(7)|kidney(2)|large_intestine(15)|lung(32)|ovary(4)|pancreas(2)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	77	Esophageal squamous(14;0.0058)|all_lung(186;0.201)|Lung NSC(181;0.203)					TCTGCACCTTCAGGTTGAGGC	0.473000													9	157					0	0	1	0	0
JAK1	3716	broad.mit.edu	37	1	65349056	65349056	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr1:65349056C>T	ENST00000342505.4	-	3	357	c.109G>A	c.(109-111)Gaa>Aaa	p.E37K		NM_002227.2	NP_002218.2	P23458	JAK1_HUMAN	Janus kinase 1	37	FERM.				interferon-gamma-mediated signaling pathway|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|response to antibiotic|type I interferon-mediated signaling pathway	cytoskeleton|cytosol|endomembrane system|membrane|nucleus	ATP binding|growth hormone receptor binding|non-membrane spanning protein tyrosine kinase activity			breast(5)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(48)|kidney(3)|large_intestine(8)|liver(2)|lung(19)|ovary(1)|prostate(12)|skin(1)|soft_tissue(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	120				BRCA - Breast invasive adenocarcinoma(111;0.0485)		AAGATCACTTCCACCCCTGGC	0.547000			Mis		ALL								8	79					0	0	1	0	0
FRYL	285527	broad.mit.edu	37	4	48578166	48578166	+	Silent	SNP	G	G	A			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr4:48578166G>A	ENST00000358350.4	-	24	3206	c.2602C>T	c.(2602-2604)Ctg>Ttg	p.L868L	FRYL_ENST00000507711.1_Silent_p.L868L|FRYL_ENST00000264319.7_5'UTR|FRYL_ENST00000537810.1_Silent_p.L868L|FRYL_ENST00000503238.1_Silent_p.L868L	NM_015030.1	NP_055845.1	O94915	FRYL_HUMAN	FRY-like	868					regulation of transcription, DNA-dependent|transcription, DNA-dependent		protein binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(21)|lung(38)|ovary(1)|pancreas(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	91						CAAAGGATCAGATAGTTTCTC	0.463000													8	94					0	0	1	0	0
BEND5	79656	broad.mit.edu	37	1	49193586	49193586	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr1:49193586C>T	ENST00000371833.3	-	6	1324	c.1238G>A	c.(1237-1239)cGa>cAa	p.R413Q	BEND5_ENST00000476096.1_5'UTR|AGBL4_ENST00000371838.1_Intron|AGBL4_ENST00000371839.1_Intron	NM_024603.2	NP_078879.2	Q7L4P6	BEND5_HUMAN	BEN domain containing 5	413										large_intestine(5)|lung(2)|skin(1)	8						TGCTTCCCTTCGTTCTTCATT	0.373000													6	84					0	0	1	0	0
SEMA5A	9037	broad.mit.edu	37	5	9052003	9052003	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr5:9052003C>G	ENST00000382496.5	-	20	3492	c.2827G>C	c.(2827-2829)Gac>Cac	p.D943H		NM_003966.2	NP_003957.2	Q13591	SEM5A_HUMAN	sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A	943	TSP type-1 7.				cell adhesion|cell-cell signaling	integral to membrane|plasma membrane				biliary_tract(1)|breast(4)|central_nervous_system(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(13)|lung(40)|ovary(2)|prostate(5)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	81						AAATTAGAGTCAAACACACAC	0.502000													4	76					0	0	1	0	0
ADRA1D	146	broad.mit.edu	37	20	4202277	4202277	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr20:4202277C>T	ENST00000379453.4	-	2	1728	c.1612G>A	c.(1612-1614)Gag>Aag	p.E538K		NM_000678.3	NP_000669.1	P25100	ADA1D_HUMAN	adrenoceptor alpha 1D	538				KPPSAFREWRLLGPFRRPTTQLRAKVSSLSHKIRAGGAQRA EAACAQRSEVEAVSLGVPHEVAEGATCQAYELADYSNLRET DI -> SHPAPSASGGCWGRSGDPRPSCAPKSPACRTRSPP GARSAQRQRAPSAQRWRLCP (in Ref. 1).	cell proliferation|cell-cell signaling|DNA metabolic process|G-protein signaling, coupled to cAMP nucleotide second messenger|multicellular organismal development|positive regulation of cell proliferation	integral to plasma membrane	alpha1-adrenergic receptor activity			endometrium(1)|large_intestine(2)|lung(7)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	14					Alfuzosin(DB00346)|Bethanidine(DB00217)|Dapiprazole(DB00298)|Debrisoquin(DB04840)|Doxazosin(DB00590)|Guanadrel Sulfate(DB00226)|Guanethidine(DB01170)|Methotrimeprazine(DB01403)|Norepinephrine(DB00368)|Promazine(DB00420)|Propericiazine(DB01608)|Propiomazine(DB00777)|Sertindole(DB06144)|Tamsulosin(DB00706)|Terazosin(DB01162)	GCCTCCACCTCTGAGCGCTGG	0.697000													4	68					0	0	1	0	0
SLC25A10	1468	broad.mit.edu	37	17	79674211	79674211	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr17:79674211G>A	ENST00000571730.1	+	5	669	c.538G>A	c.(538-540)Gag>Aag	p.E180K	SLC25A10_ENST00000541223.1_Missense_Mutation_p.E180K|MRPL12_ENST00000333676.3_Missense_Mutation_p.E180K			Q9UBX3	DIC_HUMAN	solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10	0					gluconeogenesis|mitochondrial transport	integral to membrane|mitochondrial inner membrane|nucleus	protein binding			endometrium(1)|lung(9)|ovary(1)|prostate(1)|skin(2)	14	all_neural(118;0.0878)|Ovarian(332;0.12)|all_lung(278;0.23)		BRCA - Breast invasive adenocarcinoma(99;0.0117)|OV - Ovarian serous cystadenocarcinoma(97;0.0955)		Succinic acid(DB00139)	CGCCAAAGCTGAGGCGGAGAA	0.642000													6	114					0	0	1	0	0
AMBRA1	55626	broad.mit.edu	37	11	46568686	46568686	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr11:46568686C>T	ENST00000458649.2	-	4	773	c.355G>A	c.(355-357)Gag>Aag	p.E119K	AMBRA1_ENST00000314845.3_Missense_Mutation_p.E119K|AMBRA1_ENST00000298834.3_Missense_Mutation_p.E119K|AMBRA1_ENST00000528950.1_Missense_Mutation_p.E119K|AMBRA1_ENST00000534300.1_Missense_Mutation_p.E119K|AMBRA1_ENST00000533727.1_Missense_Mutation_p.E119K|AMBRA1_ENST00000426438.1_Missense_Mutation_p.E119K			Q9C0C7	AMRA1_HUMAN	autophagy/beclin-1 regulator 1	119					autophagy|cell differentiation|nervous system development	autophagic vacuole|cytoplasmic vesicle				NS(1)|breast(3)|central_nervous_system(1)|endometrium(10)|kidney(2)|large_intestine(6)|lung(10)|ovary(2)|prostate(1)|skin(1)|urinary_tract(2)	39				GBM - Glioblastoma multiforme(35;0.0435)|Lung(87;0.182)		ATCCTAACCTCCCCATCTAGG	0.448000													8	140					0	0	1	0	0
SAYSD1	55776	broad.mit.edu	37	6	39073331	39073331	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr6:39073331C>G	ENST00000229903.4	-	2	528	c.429G>C	c.(427-429)gaG>gaC	p.E143D	SAYSD1_ENST00000373249.1_Missense_Mutation_p.E76D	NM_018322.1	NP_060792.1	Q9NPB0	CF064_HUMAN	SAYSVFN motif domain containing 1	143						integral to membrane											CCTCTTTCTTCTCTTCAGGGC	0.532000													25	164					0	0	1	0	0
L3MBTL4	91133	broad.mit.edu	37	18	6239847	6239847	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr18:6239847G>A	ENST00000400104.3	-	9	777	c.577C>T	c.(577-579)Cag>Tag	p.Q193*	L3MBTL4_ENST00000400105.2_Nonsense_Mutation_p.Q193*|L3MBTL4_ENST00000317931.7_Nonsense_Mutation_p.Q193*|L3MBTL4_ENST00000284898.6_Nonsense_Mutation_p.Q193*|L3MBTL4_ENST00000535782.1_Nonsense_Mutation_p.Q6*			Q8NA19	LMBL4_HUMAN	l(3)mbt-like 4 (Drosophila)	193					chromatin modification	nucleus	sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(17)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	39		Colorectal(10;0.0249)				ATTCCAACCTGAAATTCTTTA	0.468000													4	65					0	0	1	0	0
PHLDB1	23187	broad.mit.edu	37	11	118516501	118516501	+	Silent	SNP	G	G	A			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr11:118516501G>A	ENST00000361417.2	+	18	3876	c.3465G>A	c.(3463-3465)ctG>ctA	p.L1155L	PHLDB1_ENST00000527898.1_Silent_p.L206L|PHLDB1_ENST00000524713.1_Silent_p.L298L|PHLDB1_ENST00000356063.5_Silent_p.L1108L|PHLDB1_ENST00000534672.1_3'UTR	NM_015157.3	NP_055972.1	Q86UU1	PHLB1_HUMAN	pleckstrin homology-like domain, family B, member 1	1155										breast(3)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(10)|liver(3)|lung(14)|ovary(2)|pancreas(1)|prostate(3)|skin(1)	46	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0523)|all_hematologic(192;0.0735)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;3.4e-05)		AGAAGATGCTGAAAGAGGCTC	0.587000													8	140					0	0	1	0	0
FBXO5	26271	broad.mit.edu	37	6	153293475	153293475	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr6:153293475G>C	ENST00000367241.3	-	4	1266	c.886C>G	c.(886-888)Caa>Gaa	p.Q296E	FBXO5_ENST00000229758.3_Missense_Mutation_p.Q342E|FBXO5_ENST00000477822.1_5'UTR	NM_001142522.1	NP_001135994.1	Q9UKT4	FBX5_HUMAN	F-box protein 5	342	F-box.				anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|mitotic metaphase/anaphase transition|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of mitotic cell cycle|regulation of transcription involved in G1/S phase of mitotic cell cycle	cytosol|nucleoplasm|spindle	metal ion binding|protein binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(3)|prostate(2)|upper_aerodigestive_tract(1)	15		Ovarian(120;0.125)		OV - Ovarian serous cystadenocarcinoma(155;4.38e-10)|BRCA - Breast invasive adenocarcinoma(81;0.0893)		AACTTGGTTTGAGCATCTTTT	0.368000													5	105					0	0	1	0	0
C11orf30	56946	broad.mit.edu	37	11	76237521	76237521	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr11:76237521C>T	ENST00000529032.1	+	12	1837	c.1837C>T	c.(1837-1839)Cag>Tag	p.Q613*	C11orf30_ENST00000334736.3_Nonsense_Mutation_p.Q613*|C11orf30_ENST00000343878.3_Nonsense_Mutation_p.Q613*|C11orf30_ENST00000524490.1_Nonsense_Mutation_p.Q529*|C11orf30_ENST00000533248.1_Nonsense_Mutation_p.Q627*|C11orf30_ENST00000525038.1_Nonsense_Mutation_p.Q628*|C11orf30_ENST00000524767.1_Nonsense_Mutation_p.Q628*|C11orf30_ENST00000525919.1_Nonsense_Mutation_p.Q614*			Q7Z589	EMSY_HUMAN	chromosome 11 open reading frame 30	613	Thr-rich.				chromatin modification|DNA repair|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				NS(1)|breast(4)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(10)|liver(1)|lung(23)|ovary(5)|prostate(2)|skin(4)|stomach(1)|urinary_tract(2)	60						AAAGACTATTCAGACAGTGCC	0.363000													4	73					0	0	1	0	0
MAGI2	9863	broad.mit.edu	37	7	78150787	78150787	+	Silent	SNP	C	C	T			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr7:78150787C>T	ENST00000354212.4	-	4	967	c.714G>A	c.(712-714)gaG>gaA	p.E238E	MAGI2_ENST00000536571.1_Silent_p.E70E|MAGI2_ENST00000522391.1_Silent_p.E238E|MAGI2_ENST00000535697.1_Silent_p.E75E|MAGI2_ENST00000517762.1_5'UTR|MAGI2_ENST00000419488.1_Silent_p.E238E	NM_012301.3	NP_036433.2	Q86UL8	MAGI2_HUMAN	membrane associated guanylate kinase, WW and PDZ domain containing 2	238	Guanylate kinase-like.					cell junction|synapse|synaptosome	phosphatase binding			NS(1)|breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(12)|lung(37)|ovary(5)|prostate(1)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(3)	84		all_cancers(73;0.0064)|all_epithelial(88;0.087)|all_neural(109;0.0936)|Medulloblastoma(109;0.166)|Melanoma(862;0.236)				CCACAGGCCTCTCTTCCTCTT	0.408000													26	249					0	0	1	0	0
NUDT1	4521	broad.mit.edu	37	7	2290555	2290555	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr7:2290555G>C	ENST00000397049.1	+	5	561	c.459G>C	c.(457-459)aaG>aaC	p.K153N	NUDT1_ENST00000397048.1_Missense_Mutation_p.K153N|NUDT1_ENST00000343985.4_Missense_Mutation_p.K153N|NUDT1_ENST00000356714.1_Missense_Mutation_p.K130N|NUDT1_ENST00000487426.1_3'UTR|NUDT1_ENST00000397046.1_Missense_Mutation_p.K130N|NUDT1_ENST00000339737.2_Missense_Mutation_p.K130N	NM_198948.1|NM_198949.1	NP_945186.1|NP_945187.1	P36639	8ODP_HUMAN	nudix (nucleoside diphosphate linked moiety X)-type motif 1	171	Nudix hydrolase.				DNA protection|DNA repair|response to oxidative stress	cytoplasm	8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity|8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity|GTPase activity|metal ion binding|protein binding			large_intestine(3)|lung(8)|urinary_tract(1)	12		Ovarian(82;0.0253)|Melanoma(862;0.155)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0822)|OV - Ovarian serous cystadenocarcinoma(56;2.8e-14)|BRCA - Breast invasive adenocarcinoma(126;0.15)		TGCTTCAGAAGAAGAAATTCC	0.572000								Modulation of nucleotide pools					11	287					0	0	1	0	0
FAM46D	169966	broad.mit.edu	37	X	79698716	79698716	+	Silent	SNP	G	G	A			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chrX:79698716G>A	ENST00000538312.1	+	5	1012	c.678G>A	c.(676-678)agG>agA	p.R226R	FAM46D_ENST00000308293.5_Silent_p.R226R	NM_001170574.1	NP_001164045.1	Q8NEK8	FA46D_HUMAN	family with sequence similarity 46, member D	226										kidney(1)|large_intestine(6)|liver(3)|lung(11)|ovary(1)|upper_aerodigestive_tract(1)	23						TATGTACCAGGAAACCTGAAG	0.448000													10	50					0	0	1	0	0
EPS15	2060	broad.mit.edu	37	1	51930972	51930972	+	Silent	SNP	G	G	A			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr1:51930972G>A	ENST00000371733.3	-	6	432	c.336C>T	c.(334-336)atC>atT	p.I112I	EPS15_ENST00000371730.2_Silent_p.I112I	NM_001981.2	NP_001972.1	P42566	EPS15_HUMAN	epidermal growth factor receptor pathway substrate 15	112					cell proliferation|clathrin coat assembly|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|protein transport	cytosol|early endosome membrane	calcium ion binding|SH3 domain binding	p.0?(1)		endometrium(3)|kidney(5)|large_intestine(8)|lung(13)|prostate(2)|skin(1)|stomach(1)|urinary_tract(2)	35						AGGTTCCACTGATTAGCAAAG	0.388000			T	MLL	ALL								5	65					0	0	1	0	0
C1orf162	128346	broad.mit.edu	37	1	112019465	112019465	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr1:112019465C>T	ENST00000343534.5	+	3	333	c.83C>T	c.(82-84)gCa>gTa	p.A28V	C1orf162_ENST00000369718.3_Missense_Mutation_p.A28V|C1orf162_ENST00000464591.1_3'UTR	NM_174896.2	NP_777556.1	Q8NEQ5	CA162_HUMAN	chromosome 1 open reading frame 162	28						integral to membrane				NS(1)|kidney(1)|large_intestine(1)|lung(1)|ovary(1)	5		all_cancers(81;0.00116)|all_epithelial(167;0.000761)|all_lung(203;0.00277)|Lung NSC(277;0.0043)		Lung(183;0.0236)|Colorectal(144;0.0286)|all cancers(265;0.0572)|Epithelial(280;0.0862)|COAD - Colon adenocarcinoma(174;0.112)|LUSC - Lung squamous cell carcinoma(189;0.134)		ACTAGCCCTGCACCCTGTCTC	0.463000													8	131					0	0	1	0	0
ANKRD27	84079	broad.mit.edu	37	19	33108525	33108525	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr19:33108525C>G	ENST00000306065.4	-	21	2180	c.2022G>C	c.(2020-2022)ttG>ttC	p.L674F		NM_032139.2	NP_115515.2	Q96NW4	ANR27_HUMAN	ankyrin repeat domain 27 (VPS9 domain)	674					early endosome to late endosome transport	early endosome|lysosome	GTPase activator activity|guanyl-nucleotide exchange factor activity			breast(3)|endometrium(7)|kidney(2)|large_intestine(6)|lung(15)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(2)	42	Esophageal squamous(110;0.137)					CAACTGCTCTCAAAAGTTTTT	0.274000													4	72					0	0	1	0	0
ATAD2B	54454	broad.mit.edu	37	2	23980425	23980425	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr2:23980425G>A	ENST00000238789.5	-	25	4284	c.3941C>T	c.(3940-3942)tCa>tTa	p.S1314L	ATAD2B_ENST00000474583.1_5'UTR	NM_001242338.1|NM_017552.2	NP_001229267.1|NP_060022.1	Q9ULI0	ATD2B_HUMAN	ATPase family, AAA domain containing 2B	1314							ATP binding|nucleoside-triphosphatase activity			central_nervous_system(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TTTTTCTTTTGACTGGTCCTC	0.393000													10	200					0	0	1	0	0
PDE10A	10846	broad.mit.edu	37	6	165806202	165806202	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr6:165806202G>A	ENST00000366882.1	-	17	1713	c.1559C>T	c.(1558-1560)gCg>gTg	p.A520V	PDE10A_ENST00000539869.2_Missense_Mutation_p.A530V|PDE10A_ENST00000354448.4_Missense_Mutation_p.A520V			Q9Y233	PDE10_HUMAN	phosphodiesterase 10A	520					platelet activation|signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cAMP binding|cGMP binding|metal ion binding	p.A520V(1)		breast(4)|endometrium(5)|kidney(1)|large_intestine(13)|liver(1)|lung(39)|ovary(3)|skin(4)|upper_aerodigestive_tract(1)	71		Breast(66;0.000425)|Prostate(117;0.104)|Ovarian(120;0.221)		OV - Ovarian serous cystadenocarcinoma(33;1.5e-17)|BRCA - Breast invasive adenocarcinoma(81;1.8e-06)|GBM - Glioblastoma multiforme(31;1.92e-05)	Dipyridamole(DB00975)	TACAGTGACCGCATGCTTCCA	0.438000													8	74					0	0	1	0	0
POLR3B	55703	broad.mit.edu	37	12	106895152	106895152	+	Silent	SNP	G	G	A			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr12:106895152G>A	ENST00000228347.4	+	26	3258	c.3036G>A	c.(3034-3036)ctG>ctA	p.L1012L	POLR3B_ENST00000539066.1_Silent_p.L954L|RP11-144F15.1_ENST00000551505.1_Intron	NM_018082.5	NP_060552.4	Q9NW08	RPC2_HUMAN	polymerase (RNA) III (DNA directed) polypeptide B	1012					innate immune response|positive regulation of innate immune response|positive regulation of interferon-beta production|response to virus|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase III promoter	nucleoplasm	DNA binding|DNA-directed RNA polymerase activity|metal ion binding|ribonucleoside binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(14)|lung(22)|ovary(1)|prostate(3)|skin(3)|urinary_tract(2)	57						ATCAGAAGCTGAAACACATGG	0.438000													4	120					0	0	1	0	0
ARPC1A	10552	broad.mit.edu	37	7	98961223	98961223	+	Silent	SNP	C	C	T			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr7:98961223C>T	ENST00000432884.2	+	11	1361	c.900C>T	c.(898-900)ggC>ggT	p.G300G	ARPC1A_ENST00000262942.5_Silent_p.G347G			Q92747	ARC1A_HUMAN	actin related protein 2/3 complex, subunit 1A, 41kDa	347					actin cytoskeleton organization|regulation of actin filament polymerization	actin cytoskeleton|cytoplasm	actin binding			endometrium(3)|large_intestine(5)|liver(2)|lung(7)|ovary(1)|prostate(1)	19	all_cancers(62;4.46e-09)|all_epithelial(64;3.44e-10)|Lung NSC(181;0.0053)|all_lung(186;0.00895)|Esophageal squamous(72;0.0258)		STAD - Stomach adenocarcinoma(171;0.215)			GCACTACTGGCATCGATGGAG	0.338000													11	81					0	0	1	0	0
CYP2C18	1562	broad.mit.edu	37	10	96447916	96447916	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr10:96447916G>C	ENST00000285979.6	+	3	565	c.366G>C	c.(364-366)gaG>gaC	p.E122D	CYP2C19_ENST00000464755.1_3'UTR|CYP2C18_ENST00000339022.5_Missense_Mutation_p.E122D	NM_000772.2	NP_000763.1			cytochrome P450, family 2, subfamily C, polypeptide 18											NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(11)|ovary(3)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	26		Colorectal(252;0.09)		all cancers(201;2.8e-06)|KIRC - Kidney renal clear cell carcinoma(50;0.0646)|Kidney(138;0.0805)		GATGGAAGGAGATCCGGCGTT	0.517000													15	114					0	0	1	0	0
ABCC9	10060	broad.mit.edu	37	12	22068703	22068703	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr12:22068703G>A	ENST00000261200.4	-	5	714	c.715C>T	c.(715-717)Cac>Tac	p.H239Y	ABCC9_ENST00000261201.4_Missense_Mutation_p.H239Y|ABCC9_ENST00000345162.2_Missense_Mutation_p.H239Y	NM_020297.2	NP_064693.2	O60706	ABCC9_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 9	239					defense response to virus|potassium ion import	ATP-sensitive potassium channel complex	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium channel regulator activity|sulfonylurea receptor activity			NS(2)|breast(5)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(15)|lung(56)|ovary(4)|pancreas(1)|prostate(4)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(5)	118					Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	GGCTTTTTGTGAGCAGATATA	0.373000													9	127					0	0	1	0	0
OR1N2	138882	broad.mit.edu	37	9	125316290	125316290	+	Nonsense_Mutation	SNP	C	C	G			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr9:125316290C>G	ENST00000373688.2	+	1	900	c.842C>G	c.(841-843)tCa>tGa	p.S281*		NM_001004457.1	NP_001004457.1	Q8NGR9	OR1N2_HUMAN	olfactory receptor, family 1, subfamily N, member 2	281					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|large_intestine(6)|lung(10)|ovary(2)|skin(3)|stomach(3)	26						CTTCCTCCATCAACTTACTCT	0.463000													10	151					0	0	1	0	0
NFATC2	4773	broad.mit.edu	37	20	50140149	50140149	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr20:50140149G>C	ENST00000371564.3	-	2	850	c.631C>G	c.(631-633)Cat>Gat	p.H211D	NFATC2_ENST00000414705.1_Missense_Mutation_p.H191D|NFATC2_ENST00000396009.3_Missense_Mutation_p.H211D	NM_001258296.1|NM_012340.4	NP_001245225.1|NP_036472.2	Q13469	NFAC2_HUMAN	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2	211	3 X approximate SP repeats.				B cell receptor signaling pathway|positive regulation of B cell proliferation|response to DNA damage stimulus|response to drug	actin cytoskeleton|nucleus|plasma membrane	protein binding|sequence-specific DNA binding transcription factor activity		EWSR1/NFATC2(9)	breast(2)|endometrium(7)|kidney(1)|large_intestine(7)|lung(25)|ovary(2)|prostate(2)|skin(5)|stomach(1)|urinary_tract(1)	53	Hepatocellular(150;0.248)					GGGGAATAATGAGCAGGGATG	0.632000													7	161					0	0	1	0	0
NDNF	79625	broad.mit.edu	37	4	121958385	121958385	+	Silent	SNP	G	G	A			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr4:121958385G>A	ENST00000379692.4	-	4	1267	c.741C>T	c.(739-741)ttC>ttT	p.F247F	NDNF_ENST00000506900.1_5'UTR	NM_024574.3	NP_078850.3	Q8TB73	CD031_HUMAN	neuron-derived neurotrophic factor	247										breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(10)|prostate(3)|skin(1)|urinary_tract(1)	29						CAAAGGGGCTGAAGTCCAGAC	0.453000													5	74					0	0	1	0	0
REV3L	5980	broad.mit.edu	37	6	111694120	111694120	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr6:111694120G>A	ENST00000435970.1	-	15	6020	c.5204C>T	c.(5203-5205)tCa>tTa	p.S1735L	REV3L_ENST00000368805.1_Missense_Mutation_p.S1813L|REV3L_ENST00000368802.3_Missense_Mutation_p.S1813L|REV3L_ENST00000358835.3_Missense_Mutation_p.S1813L			O60673	DPOLZ_HUMAN	REV3-like, polymerase (DNA directed), zeta, catalytic subunit	1813					DNA-dependent DNA replication|translesion synthesis	nucleus|zeta DNA polymerase complex	DNA binding|DNA-directed DNA polymerase activity|metal ion binding|nucleotide binding			NS(2)|breast(1)|endometrium(6)|kidney(7)|large_intestine(30)|lung(25)|ovary(3)|prostate(5)|skin(8)|upper_aerodigestive_tract(1)	88		all_cancers(87;7.57e-06)|Acute lymphoblastic leukemia(125;2.46e-08)|all_hematologic(75;1.08e-06)|all_epithelial(87;0.00138)|Colorectal(196;0.021)		OV - Ovarian serous cystadenocarcinoma(136;0.0314)|Epithelial(106;0.057)|all cancers(137;0.0663)		GGTATTGGCTGAGTCAAGAGA	0.423000								DNA polymerases (catalytic subunits)					11	199					0	0	1	0	0
PTPRB	5787	broad.mit.edu	37	12	70983815	70983815	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr12:70983815C>A	ENST00000334414.6	-	8	2023	c.1979G>T	c.(1978-1980)aGa>aTa	p.R660I	PTPRB_ENST00000550857.1_Intron|PTPRB_ENST00000538174.2_5'UTR|PTPRB_ENST00000451516.2_Intron|PTPRB_ENST00000261266.5_Missense_Mutation_p.R442I|PTPRB_ENST00000538708.1_Missense_Mutation_p.R442I|PTPRB_ENST00000550358.1_Missense_Mutation_p.R660I|PTPRB_ENST00000551525.1_Missense_Mutation_p.R659I	NM_001109754.2	NP_001103224.1	P23467	PTPRB_HUMAN	protein tyrosine phosphatase, receptor type, B	442	Fibronectin type-III 8.				angiogenesis	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			breast(4)|central_nervous_system(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(8)|lung(46)|prostate(4)|skin(18)|upper_aerodigestive_tract(1)|urinary_tract(3)	107	Renal(347;0.236)		GBM - Glioblastoma multiforme(2;2.17e-05)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00306)|STAD - Stomach adenocarcinoma(21;0.149)			CTCATACTGTCTTCCCGGTAC	0.458000											OREG0021990	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	8	117					0.00307968	0.00311428	1	1	0
UGGT2	55757	broad.mit.edu	37	13	96675963	96675963	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr13:96675963G>C	ENST00000376747.3	-	3	362	c.292C>G	c.(292-294)Cta>Gta	p.L98V	UGGT2_ENST00000397618.3_Missense_Mutation_p.L98V|UGGT2_ENST00000376712.4_Missense_Mutation_p.L98V|UGGT2_ENST00000376714.3_Missense_Mutation_p.L98V	NM_020121.3	NP_064506.3	Q9NYU1	UGGG2_HUMAN	UDP-glucose glycoprotein glucosyltransferase 2	98					post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum lumen|ER-Golgi intermediate compartment	UDP-glucose:glycoprotein glucosyltransferase activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(17)|lung(20)|ovary(3)|pancreas(1)|prostate(4)|urinary_tract(2)	60						AAATTGTCTAGAAACTGTCCA	0.328000													10	170					0	0	1	0	0
POM121	9883	broad.mit.edu	37	7	72413727	72413727	+	Silent	SNP	C	C	T			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr7:72413727C>T	ENST00000395270.1	+	14	3441	c.2400C>T	c.(2398-2400)ttC>ttT	p.F800F	POM121_ENST00000257622.4_Silent_p.F800F|POM121_ENST00000358357.3_Silent_p.F800F|POM121_ENST00000434423.2_Silent_p.F1065F|POM121_ENST00000446813.1_Silent_p.F800F	NM_001257190.1	NP_001244119.1	Q96HA1	P121A_HUMAN	POM121 transmembrane nucleoporin	1065	Pore side (Potential).|Thr-rich.				carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	endoplasmic reticulum membrane|nuclear membrane|nuclear pore				NS(1)|breast(1)|endometrium(9)|kidney(4)|large_intestine(6)|lung(12)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	41		Lung NSC(55;0.163)				CTGTCTTCTTCGGTGCAGCCA	0.657000													4	92					0	0	1	0	0
YTHDC2	64848	broad.mit.edu	37	5	112871475	112871475	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr5:112871475G>A	ENST00000161863.4	+	7	1295	c.1082G>A	c.(1081-1083)gGa>gAa	p.G361E	YTHDC2_ENST00000515883.1_Missense_Mutation_p.G361E	NM_022828.3	NP_073739.3	Q9H6S0	YTDC2_HUMAN	YTH domain containing 2	361	Helicase ATP-binding.						ATP binding|ATP-dependent helicase activity|nucleic acid binding			NS(2)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(6)|large_intestine(13)|lung(10)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	43		all_cancers(142;7.69e-05)|all_epithelial(76;6.42e-07)|Colorectal(10;0.00278)|Prostate(80;0.00955)|Ovarian(225;0.0444)|Lung NSC(810;0.143)|all_lung(232;0.163)|Breast(839;0.244)		OV - Ovarian serous cystadenocarcinoma(64;7.2e-08)|Epithelial(69;8.83e-08)|all cancers(49;6.9e-06)|COAD - Colon adenocarcinoma(37;0.0458)|Colorectal(14;0.0594)		AGATATTTTGGAAGTTGTCCA	0.299000													3	35					0	0	1	0	0
SCN1A	6323	broad.mit.edu	37	2	166894586	166894586	+	Silent	SNP	G	G	A			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr2:166894586G>A	ENST00000423058.2	-	15	2663	c.2646C>T	c.(2644-2646)atC>atT	p.I882I	AC010127.3_ENST00000595268.1_RNA|SCN1A_ENST00000375405.3_Silent_p.I871I|AC010127.3_ENST00000595647.1_RNA|SCN1A_ENST00000303395.4_Silent_p.I882I|SCN1A_ENST00000409050.1_Silent_p.I854I|AC010127.3_ENST00000599041.1_RNA	NM_001165963.1|NM_001202435.1	NP_001159435.1|NP_001189364.1	P35498	SCN1A_HUMAN	sodium channel, voltage-gated, type I, alpha subunit	882						voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(4)|breast(5)|endometrium(16)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(33)|lung(87)|ovary(7)|pancreas(1)|prostate(9)|skin(23)|upper_aerodigestive_tract(2)|urinary_tract(1)	200					Lamotrigine(DB00555)|Levetiracetam(DB01202)|Phenacemide(DB01121)|Phenytoin(DB00252)|Topiramate(DB00273)|Zonisamide(DB00909)	AATTGCCGATGATCTTTATTA	0.403000													6	118					0	0	1	0	0
CCDC54	84692	broad.mit.edu	37	3	107097120	107097120	+	Nonsense_Mutation	SNP	C	C	A			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr3:107097120C>A	ENST00000261058.1	+	1	933	c.686C>A	c.(685-687)tCa>tAa	p.S229*		NM_032600.2	NP_115989.1	Q8NEL0	CCD54_HUMAN	coiled-coil domain containing 54	229										NS(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(8)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	19						CAAAATGCATCAAGGAGCTTT	0.368000													10	147					4.68919e-08	4.79576e-08	1	1	0
GPR179	440435	broad.mit.edu	37	17	36486420	36486420	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr17:36486420C>T	ENST00000342292.4	-	11	3052	c.3032G>A	c.(3031-3033)gGc>gAc	p.G1011D		NM_001004334.2	NP_001004334.2	Q6PRD1	GP179_HUMAN	G protein-coupled receptor 179	1011						integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(4)|cervix(2)|endometrium(9)|kidney(3)|large_intestine(16)|lung(15)|ovary(4)|pancreas(1)|prostate(1)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	60	Breast(7;2.97e-12)	Breast(25;0.0101)|Ovarian(249;0.15)				CCCTGAGGGGCCTTCCTGGGG	0.622000													9	63					0	0	1	0	0
TGM4	7047	broad.mit.edu	37	3	44952515	44952515	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr3:44952515G>A	ENST00000296125.4	+	12	1740	c.1672G>A	c.(1672-1674)Gag>Aag	p.E558K		NM_003241.3	NP_003232.2	P49221	TGM4_HUMAN	transglutaminase 4	558					peptide cross-linking|protein polyamination		acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			NS(1)|breast(1)|endometrium(2)|large_intestine(9)|lung(21)|ovary(2)|stomach(1)|upper_aerodigestive_tract(1)	38				BRCA - Breast invasive adenocarcinoma(193;0.00963)|KIRC - Kidney renal clear cell carcinoma(197;0.0546)|Kidney(197;0.0686)	L-Glutamine(DB00130)	ATTAGATGATGAGCCAGTTAT	0.458000													7	90					0	0	1	0	0
CNNM3	26505	broad.mit.edu	37	2	97490929	97490929	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr2:97490929G>A	ENST00000305510.3	+	2	1388	c.1360G>A	c.(1360-1362)Gaa>Aaa	p.E454K	CNNM3_ENST00000377060.3_Intron|ANKRD23_ENST00000476975.1_Intron	NM_017623.4	NP_060093.3	Q8NE01	CNNM3_HUMAN	cyclin M3	454					ion transport	integral to membrane|plasma membrane	protein binding			NS(1)|kidney(2)|large_intestine(2)|lung(3)|ovary(2)|skin(1)|urinary_tract(2)	13						GGACGAGTCTGAAGACTACCG	0.607000													3	34					0	0	1	0	0
ZBTB20	26137	broad.mit.edu	37	3	114070460	114070460	+	Silent	SNP	A	A	T			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr3:114070460A>T	ENST00000462705.1	-	11	1067	c.246T>A	c.(244-246)atT>atA	p.I82I	ZBTB20_ENST00000393785.2_Silent_p.I82I|ZBTB20_ENST00000474710.1_Silent_p.I155I|ZBTB20_ENST00000357258.3_Silent_p.I82I|ZBTB20_ENST00000464560.1_Silent_p.I82I|ZBTB20_ENST00000481632.1_Silent_p.I82I|ZBTB20_ENST00000471418.1_Silent_p.I82I	NM_001164343.1	NP_001157815.1	Q9HC78	ZBT20_HUMAN	zinc finger and BTB domain containing 20	155					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(10)|kidney(2)|large_intestine(8)|lung(15)|ovary(4)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	48				LUSC - Lung squamous cell carcinoma(41;0.0581)|Lung(219;0.191)		ACATGAAGTCAATGAGCTTTT	0.577000													13	72					0	0	1	0	0
TLE1	7088	broad.mit.edu	37	9	84226786	84226786	+	Silent	SNP	C	C	T			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr9:84226786C>T	ENST00000376499.3	-	13	2216	c.1152G>A	c.(1150-1152)ctG>ctA	p.L384L	TLE1_ENST00000464999.1_5'UTR|TLE1_ENST00000376472.1_Silent_p.L59L|TLE1_ENST00000376484.1_Silent_p.L59L	NM_005077.3	NP_005068.2	Q04724	TLE1_HUMAN	transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)	384	Pro/Ser-rich.				negative regulation of Wnt receptor signaling pathway|organ morphogenesis|transcription, DNA-dependent|Wnt receptor signaling pathway		transcription factor binding			NS(1)|endometrium(5)|kidney(2)|large_intestine(2)|lung(11)|ovary(1)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	29						CTGGGCTGGTCAGCTCGCCGT	0.672000													4	57					0	0	1	0	0
BTN2A2	10385	broad.mit.edu	37	6	26393148	26393148	+	Missense_Mutation	SNP	G	G	A	rs114098566	by1000genomes	TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr6:26393148G>A	ENST00000356709.4	+	8	1636	c.1525G>A	c.(1525-1527)Gaa>Aaa	p.E509K	BTN2A2_ENST00000482536.1_Missense_Mutation_p.E299K|BTN2A2_ENST00000469230.1_Intron|BTN2A2_ENST00000416795.2_Missense_Mutation_p.E509K|BTN2A2_ENST00000432533.2_3'UTR|BTN2A2_ENST00000352867.2_Missense_Mutation_p.E393K	NM_001197240.1|NM_006995.4	NP_001184169.1|NP_008926.2	Q8WVV5	BT2A2_HUMAN	butyrophilin, subfamily 2, member A2	509					negative regulation of activated T cell proliferation|negative regulation of cellular metabolic process|negative regulation of cytokine secretion	integral to membrane				breast(2)|endometrium(3)|large_intestine(5)|lung(13)	23						CATGGTGCCTGAAGAGGGCCT	0.552000													7	67					0	0	1	0	0
UBE3C	9690	broad.mit.edu	37	7	157046701	157046701	+	Silent	SNP	G	G	C			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr7:157046701G>C	ENST00000348165.5	+	20	3108	c.2748G>C	c.(2746-2748)cgG>cgC	p.R916R		NM_014671.2	NP_055486.2	Q15386	UBE3C_HUMAN	ubiquitin protein ligase E3C	916	HECT.				protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus|proteasome complex	protein binding|ubiquitin-protein ligase activity			central_nervous_system(2)|endometrium(3)|kidney(16)|large_intestine(13)|lung(25)|ovary(2)|prostate(1)|urinary_tract(1)	63		all_hematologic(28;0.0185)|all_epithelial(9;0.0664)	OV - Ovarian serous cystadenocarcinoma(82;0.00448)	UCEC - Uterine corpus endometrioid carcinoma (81;0.19)		GCGCCAACCGGATTGCGTACA	0.517000													7	46					0	0	1	0	0
ENPP6	133121	broad.mit.edu	37	4	185012400	185012400	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr4:185012400G>A	ENST00000296741.2	-	8	1394	c.1253C>T	c.(1252-1254)gCc>gTc	p.A418V		NM_153343.3	NP_699174.1	Q6UWR7	ENPP6_HUMAN	ectonucleotide pyrophosphatase/phosphodiesterase 6	418					lipid catabolic process	extracellular region|integral to membrane|plasma membrane				breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(5)|skin(2)	15		all_lung(41;7.99e-12)|Lung NSC(41;1.46e-11)|Colorectal(36;0.00435)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|all_hematologic(60;0.0749)		all cancers(43;4.98e-27)|Epithelial(43;3.15e-24)|OV - Ovarian serous cystadenocarcinoma(60;4.09e-12)|Colorectal(24;3.78e-05)|STAD - Stomach adenocarcinoma(60;4.5e-05)|COAD - Colon adenocarcinoma(29;0.000154)|GBM - Glioblastoma multiforme(59;0.000167)|BRCA - Breast invasive adenocarcinoma(30;0.000378)|LUSC - Lung squamous cell carcinoma(40;0.0151)		GGCAGTGCTGGCGCGGCCCTT	0.562000													6	73					0	0	1	0	0
TRIM15	89870	broad.mit.edu	37	6	30138306	30138306	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr6:30138306G>C	ENST00000376694.4	+	5	1229	c.760G>C	c.(760-762)Gag>Cag	p.E254Q	TRIM15_ENST00000376688.1_Intron	NM_033229.2	NP_150232.2	Q9C019	TRI15_HUMAN	tripartite motif containing 15	254					mesodermal cell fate determination	intracellular	zinc ion binding			large_intestine(2)|lung(8)|prostate(2)|skin(1)|urinary_tract(1)	14						TGTGAGTCCTGAGGCCATTTC	0.473000													7	86					0	0	1	0	0
PCDHB13	56123	broad.mit.edu	37	5	140594698	140594698	+	Silent	SNP	C	C	T			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr5:140594698C>T	ENST00000341948.4	+	1	1190	c.1003C>T	c.(1003-1005)Ctg>Ttg	p.L335L		NM_018933.2	NP_061756.1	Q9Y5F0	PCDBD_HUMAN		335	Cadherin 3.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			NS(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(14)|liver(4)|lung(24)|ovary(5)|pancreas(1)|skin(4)|upper_aerodigestive_tract(1)	66			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			ATGCACCGTTCTGATTCAAGT	0.423000													22	256					0	0	1	0	0
C12orf5	57103	broad.mit.edu	37	12	4430449	4430449	+	Silent	SNP	C	C	T			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr12:4430449C>T	ENST00000179259.4	+	1	79	c.12C>T	c.(10-12)ttC>ttT	p.F4F		NM_020375.2	NP_065108.1	Q9NQ88	TIGAR_HUMAN	chromosome 12 open reading frame 5	4						intracellular	fructose-2,6-bisphosphate 2-phosphatase activity			endometrium(1)|large_intestine(1)|lung(5)|skin(3)	10			all cancers(3;1.15e-07)|Colorectal(7;0.00165)|OV - Ovarian serous cystadenocarcinoma(31;0.00596)|COAD - Colon adenocarcinoma(12;0.0229)|GBM - Glioblastoma multiforme(3;0.0266)|STAD - Stomach adenocarcinoma(119;0.206)			TGGCTCGCTTCGCTCTGACTG	0.647000													4	72					0	0	1	0	0
ITGAD	3681	broad.mit.edu	37	16	31429877	31429877	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr16:31429877G>A	ENST00000389202.2	+	23	2821	c.2772G>A	c.(2770-2772)atG>atA	p.M924I		NM_005353.2	NP_005344.2	Q13349	ITAD_HUMAN	integrin, alpha D	924					cell-cell adhesion|cell-matrix adhesion|immune response|integrin-mediated signaling pathway	integrin complex	receptor activity			breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|liver(2)|lung(43)|ovary(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	71						TCTACACCATGATCAGCAGGT	0.557000													5	92					0	0	1	0	0
TOP2A	7153	broad.mit.edu	37	17	38573102	38573102	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr17:38573102C>G	ENST00000423485.1	-	2	225	c.67G>C	c.(67-69)Gat>Cat	p.D23H		NM_001067.3	NP_001058.2	P11388	TOP2A_HUMAN	topoisomerase (DNA) II alpha 170kDa	23					apoptotic chromosome condensation|DNA ligation|DNA repair|DNA topological change|DNA-dependent DNA replication|mitotic cell cycle G2/M transition decatenation checkpoint|mitotic recombination|phosphatidylinositol-mediated signaling|positive regulation of apoptosis|positive regulation of retroviral genome replication|resolution of meiotic recombination intermediates|sister chromatid segregation	cytoplasm|DNA topoisomerase complex (ATP-hydrolyzing)|nucleolus|nucleoplasm|synaptonemal complex	ATP binding|chromatin binding|DNA topoisomerase (ATP-hydrolyzing) activity|DNA-dependent ATPase activity|drug binding|histone deacetylase binding|protein C-terminus binding|protein heterodimerization activity|protein homodimerization activity|protein kinase C binding|sequence-specific DNA binding transcription factor activity|ubiquitin binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(8)|lung(9)|ovary(5)|pancreas(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)	39		Breast(137;0.00328)	STAD - Stomach adenocarcinoma(5;0.00183)		Amsacrine(DB00276)|Ciprofloxacin(DB00537)|Dexrazoxane(DB00380)|Doxorubicin(DB00997)|Enoxacin(DB00467)|Epirubicin(DB00445)|Etoposide(DB00773)|Fleroxacin(DB04576)|Gatifloxacin(DB01044)|Idarubicin(DB01177)|Levofloxacin(DB01137)|Lomefloxacin(DB00978)|Lucanthone(DB04967)|Mitoxantrone(DB01204)|Moxifloxacin(DB00218)|Norfloxacin(DB01059)|Ofloxacin(DB01165)|Pefloxacin(DB00487)|Podofilox(DB01179)|Sparfloxacin(DB01208)|Teniposide(DB00444)|Trovafloxacin(DB00685)|Valrubicin(DB00385)	TTCTTAGCATCTTCATTTTTC	0.318000													5	84					0	0	1	0	0
FOXP1	27086	broad.mit.edu	37	3	71027138	71027138	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr3:71027138C>T	ENST00000318789.4	-	15	1714	c.1189G>A	c.(1189-1191)Gag>Aag	p.E397K	FOXP1_ENST00000498215.1_Missense_Mutation_p.E397K|FOXP1_ENST00000491238.1_Missense_Mutation_p.E399K|FOXP1_ENST00000493089.1_Missense_Mutation_p.E397K|FOXP1_ENST00000468577.1_Missense_Mutation_p.E397K|FOXP1_ENST00000484350.1_Missense_Mutation_p.E321K|FOXP1_ENST00000475937.1_Missense_Mutation_p.E397K	NM_001244810.1|NM_001244813.1|NM_032682.5	NP_001231739.1|NP_001231742.1|NP_116071.2	Q9H334	FOXP1_HUMAN	forkhead box P1	397					cardiac muscle cell differentiation|embryo development|immunoglobulin V(D)J recombination|pattern specification process|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of immunoglobulin production|positive regulation of mesenchymal cell proliferation|pre-B cell differentiation|regulation of sequence-specific DNA binding transcription factor activity|skeletal muscle tissue development|smooth muscle tissue development	cytoplasm|transcription factor complex	chromatin binding|DNA bending activity|double-stranded DNA binding|promoter binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|zinc ion binding			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(7)|lung(8)|ovary(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	31		Lung NSC(201;4.62e-05)|Prostate(10;0.0181)|Hepatocellular(537;0.186)|Myeloproliferative disorder(1037;0.209)		BRCA - Breast invasive adenocarcinoma(55;1.17e-05)|Epithelial(33;1.39e-05)|LUSC - Lung squamous cell carcinoma(21;2.35e-05)|Lung(16;4.26e-05)		GGAGAAGCCTCCGATGCGGAC	0.527000			T	PAX5	ALL								5	150					0	0	1	0	0
KATNB1	10300	broad.mit.edu	37	16	57786825	57786825	+	Silent	SNP	C	C	T			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr16:57786825C>T	ENST00000379661.3	+	10	1232	c.840C>T	c.(838-840)atC>atT	p.I280I		NM_005886.2	NP_005877.2	Q9BVA0	KTNB1_HUMAN	katanin p80 (WD repeat containing) subunit B 1	280	Interaction with centrosomes.|Interaction with dynein (By similarity).				cell division|mitosis|negative regulation of microtubule depolymerization|positive regulation of microtubule depolymerization|protein targeting	katanin complex|microtubule|spindle pole	microtubule binding|protein heterodimerization activity			cervix(1)|endometrium(3)|kidney(2)|large_intestine(1)|lung(6)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	16		all_neural(199;0.223)				ACCTGGCCATCTGCAATGACC	0.667000													3	21					0	0	1	0	0
ZNF383	163087	broad.mit.edu	37	19	37733871	37733871	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr19:37733871C>G	ENST00000589413.1	+	8	1316	c.733C>G	c.(733-735)Cag>Gag	p.Q245E	ZNF383_ENST00000352998.3_Missense_Mutation_p.Q245E|ZNF383_ENST00000590503.1_Missense_Mutation_p.Q245E			Q8NA42	ZN383_HUMAN	zinc finger protein 383	245					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding	p.Q245E(1)		NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(8)|ovary(1)|skin(1)	15			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			TTCTCAACATCAGAGAATCCA	0.408000													5	80					0	0	1	0	0
CD38	952	broad.mit.edu	37	4	15850186	15850186	+	Silent	SNP	G	G	C			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr4:15850186G>C	ENST00000226279.2	+	8	1001	c.864G>C	c.(862-864)gtG>gtC	p.V288V		NM_001775.2	NP_001766.2	P28907	CD38_HUMAN	CD38 molecule	288					B cell receptor signaling pathway|induction of apoptosis by extracellular signals|negative regulation of apoptosis|negative regulation of transcription, DNA-dependent|positive regulation of B cell proliferation|positive regulation of transcription, DNA-dependent|response to drug	integral to membrane|plasma membrane	binding|NAD+ nucleosidase activity|receptor activity			endometrium(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(2)|prostate(1)|stomach(1)	14						TTCAGTGTGTGAAAAATCCTG	0.428000													9	86					0	0	1	0	0
ASIC1	41	broad.mit.edu	37	12	50473825	50473825	+	Nonsense_Mutation	SNP	G	G	T			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr12:50473825G>T	ENST00000228468.4	+	8	1577	c.1192G>T	c.(1192-1194)Gag>Tag	p.E398*	ASIC1_ENST00000447966.2_Nonsense_Mutation_p.E398*|ASIC1_ENST00000552438.1_Nonsense_Mutation_p.E432*	NM_020039.3	NP_064423.2	P78348	ACCN2_HUMAN	acid-sensing (proton-gated) ion channel 1	398					calcium ion transport|response to pH|signal transduction	integral to plasma membrane	ligand-gated sodium channel activity|protein binding									Amiloride(DB00594)	CAACAAATCTGAGCAATACAT	0.557000													4	69					0.150653	0.150653	1	1	0
NUDT17	200035	broad.mit.edu	37	1	145586858	145586858	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr1:145586858C>G	ENST00000334513.5	-	7	841	c.830G>C	c.(829-831)aGa>aCa	p.R277T		NM_001012758.2	NP_001012776.1	P0C025	NUD17_HUMAN	nudix (nucleoside diphosphate linked moiety X)-type motif 17	277							hydrolase activity|metal ion binding			endometrium(3)|large_intestine(1)|lung(2)|skin(1)|urinary_tract(2)	9	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					AGTGCTGACTCTCTCTTTGTC	0.547000													14	210					0	0	1	0	0
KIAA1109	84162	broad.mit.edu	37	4	123275103	123275103	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr4:123275103G>A	ENST00000264501.4	+	82	14609	c.14236G>A	c.(14236-14238)Gaa>Aaa	p.E4746K	KIAA1109_ENST00000388738.3_Missense_Mutation_p.E4746K			Q2LD37	K1109_HUMAN	KIAA1109	4746					regulation of cell growth|regulation of epithelial cell differentiation	integral to membrane|nucleus				breast(7)|central_nervous_system(1)|cervix(1)|endometrium(16)|kidney(6)|large_intestine(33)|liver(4)|lung(74)|ovary(9)|pancreas(1)|prostate(5)|skin(6)|upper_aerodigestive_tract(6)|urinary_tract(3)	172						GCGTCGCCATGAAAATCCACC	0.388000													5	68					0	0	1	0	0
SPR	6697	broad.mit.edu	37	2	73115471	73115471	+	Silent	SNP	C	C	T			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr2:73115471C>T	ENST00000234454.5	+	2	406	c.333C>T	c.(331-333)ttC>ttT	p.F111F	SPR_ENST00000498749.1_Intron	NM_003124.4	NP_003115.1	P35270	SPRE_HUMAN	sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)	111					nitric oxide biosynthetic process|tetrahydrobiopterin biosynthetic process	cytoplasm	aldo-keto reductase (NADP) activity|NADP binding|sepiapterin reductase activity			lung(4)|ovary(2)	6						CCAAAGGCTTCGTGGACCTGA	0.552000											OREG0014704	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	8	119					0	0	1	0	0
DEPDC1	55635	broad.mit.edu	37	1	68948054	68948054	+	Silent	SNP	G	G	A			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr1:68948054G>A	ENST00000456315.2	-	8	1551	c.1437C>T	c.(1435-1437)ttC>ttT	p.F479F	RP4-694A7.2_ENST00000425820.1_RNA|DEPDC1_ENST00000370966.5_Intron	NM_001114120.1	NP_001107592.1	Q5TB30	DEP1A_HUMAN	DEP domain containing 1	479					intracellular signal transduction|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	transcriptional repressor complex	GTPase activator activity|protein binding			endometrium(1)|kidney(1)|large_intestine(3)|lung(4)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	13				OV - Ovarian serous cystadenocarcinoma(397;7.21e-36)		AACCAGCACTGAATGGCTTTT	0.373000													5	52					0	0	1	0	0
NUP133	55746	broad.mit.edu	37	1	229633923	229633923	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr1:229633923G>C	ENST00000261396.3	-	6	870	c.779C>G	c.(778-780)tCt>tGt	p.S260C	NUP133_ENST00000537506.1_Missense_Mutation_p.S244C|NUP133_ENST00000366679.1_Missense_Mutation_p.S260C	NM_018230.2	NP_060700.2	Q8WUM0	NU133_HUMAN	nucleoporin 133kDa	260					carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA export from nucleus|nuclear pore organization|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytosol|Nup107-160 complex	nucleocytoplasmic transporter activity|protein binding	p.S260F(1)		NS(1)|breast(7)|endometrium(1)|kidney(6)|large_intestine(9)|lung(20)|ovary(1)|pancreas(1)|prostate(3)|skin(3)|stomach(4)	56	Breast(184;0.104)|Ovarian(103;0.249)	Prostate(94;0.167)				AAAAAGAGAAGAAACTTTTCG	0.353000													5	88					0	0	1	0	0
RNF165	494470	broad.mit.edu	37	18	44015328	44015328	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr18:44015328C>G	ENST00000269439.7	+	3	505	c.454C>G	c.(454-456)Cag>Gag	p.Q152E	RNF165_ENST00000543885.1_Intron	NM_152470.2	NP_689683.2	Q6ZSG1	RN165_HUMAN	ring finger protein 165	152							zinc ion binding			NS(1)|large_intestine(4)|lung(6)	11				READ - Rectum adenocarcinoma(1;0.0873)		GCAGACACCTCAGCCCAGGTA	0.627000													4	58					0	0	1	0	0
MUC13	56667	broad.mit.edu	37	3	124653538	124653538	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr3:124653538G>C	ENST00000311075.3	-	1	57	c.19C>G	c.(19-21)Ctt>Gtt	p.L7V	MUC13_ENST00000497378.1_Intron	NM_033049.3	NP_149038.3	Q9H3R2	MUC13_HUMAN	mucin 13, cell surface associated	7						extracellular region|integral to membrane|plasma membrane				breast(1)|central_nervous_system(1)|cervix(1)|kidney(1)|large_intestine(6)|lung(5)|prostate(1)|skin(1)|stomach(1)	18						AGAAGAGTAAGATGAATGATG	0.378000													4	86					0	0	1	0	0
IL17A	3605	broad.mit.edu	37	6	52053869	52053869	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr6:52053869G>C	ENST00000340057.1	+	3	292	c.247G>C	c.(247-249)Gag>Cag	p.E83Q		NM_002190.2	NP_002181.1	Q16552	IL17_HUMAN	interleukin 17A	83					apoptosis|cell-cell signaling|fibroblast activation|immune response|inflammatory response|positive regulation of interleukin-23 production|positive regulation of osteoclast differentiation|positive regulation of transcription from RNA polymerase II promoter|protein glycosylation	extracellular space	cytokine activity			endometrium(3)|large_intestine(2)|lung(8)|prostate(3)|skin(1)	17	Lung NSC(77;0.116)					TGAGGACCCTGAGAGATATCC	0.502000													4	32					0	0	1	0	0
SERPINE3	647174	broad.mit.edu	37	13	51915427	51915427	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr13:51915427G>A	ENST00000524365.1	+	4	825	c.200G>A	c.(199-201)gGa>gAa	p.G67E	SERPINE3_ENST00000400389.4_Missense_Mutation_p.G67E|SERPINE3_ENST00000521255.1_Missense_Mutation_p.G67E			A8MV23	SERP3_HUMAN	serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 3	67					regulation of proteolysis	extracellular region	serine-type endopeptidase inhibitor activity			ovary(2)	2						CTGCAGTTTGGAGCAGAAGGG	0.572000													3	37					0	0	1	0	0
ZBTB40	9923	broad.mit.edu	37	1	22838582	22838582	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr1:22838582C>T	ENST00000404138.1	+	12	2927	c.2416C>T	c.(2416-2418)Cca>Tca	p.P806S	ZBTB40_ENST00000374651.4_Missense_Mutation_p.P694S|ZBTB40_ENST00000375647.4_Missense_Mutation_p.P806S	NM_001083621.1	NP_001077090.1	Q9NUA8	ZBT40_HUMAN	zinc finger and BTB domain containing 40	806					bone mineralization|regulation of transcription, DNA-dependent|response to DNA damage stimulus|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(4)|kidney(4)|large_intestine(6)|lung(8)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	26		Colorectal(325;3.46e-05)|Lung NSC(340;6.55e-05)|all_lung(284;9.87e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;2.86e-26)|Colorectal(126;8.55e-08)|COAD - Colon adenocarcinoma(152;4.1e-06)|GBM - Glioblastoma multiforme(114;1.39e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000712)|KIRC - Kidney renal clear cell carcinoma(1967;0.00374)|STAD - Stomach adenocarcinoma(196;0.00645)|READ - Rectum adenocarcinoma(331;0.0693)|Lung(427;0.216)		GAAGAGGCTTCCAGTGACATG	0.498000													4	79					0	0	1	0	0
TRPM7	54822	broad.mit.edu	37	15	50888513	50888513	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr15:50888513G>A	ENST00000313478.7	-	23	3510	c.3229C>T	c.(3229-3231)Caa>Taa	p.Q1077*	TRPM7_ENST00000560955.1_Nonsense_Mutation_p.Q1077*	NM_017672.4	NP_060142.3	Q96QT4	TRPM7_HUMAN	transient receptor potential cation channel, subfamily M, member 7	1077					cell death	integral to membrane	ATP binding|calcium channel activity|metal ion binding|protein serine/threonine kinase activity			breast(3)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(17)|lung(13)|ovary(4)|pancreas(1)|skin(4)|stomach(3)	52				all cancers(107;0.000819)|GBM - Glioblastoma multiforme(94;0.0045)		TAGACTGCTTGAAGAAATGGA	0.318000													8	120					0	0	1	0	0
COLGALT2	23127	broad.mit.edu	37	1	183913451	183913451	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr1:183913451C>T	ENST00000361927.4	-	10	1647	c.1276G>A	c.(1276-1278)Gat>Aat	p.D426N	COLGALT2_ENST00000546159.1_Missense_Mutation_p.D426N|COLGALT2_ENST00000367520.3_Missense_Mutation_p.D163N|COLGALT2_ENST00000367521.1_Missense_Mutation_p.D34N	NM_015101.2	NP_055916.1			collagen beta(1-O)galactosyltransferase 2																		AGCTCTCGATCAATTACCTGC	0.363000													5	86					0	0	1	0	0
ITGB6	3694	broad.mit.edu	37	2	160968678	160968678	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr2:160968678G>C	ENST00000283249.2	-	13	2251	c.2014C>G	c.(2014-2016)Ctg>Gtg	p.L672V	ITGB6_ENST00000428609.2_Missense_Mutation_p.L630V|ITGB6_ENST00000409872.1_Missense_Mutation_p.L672V|ITGB6_ENST00000409967.2_Missense_Mutation_p.L565V			P18564	ITB6_HUMAN	integrin, beta 6	672					cell-matrix adhesion|integrin-mediated signaling pathway|interspecies interaction between organisms|multicellular organismal development	integrin complex	receptor activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(8)|lung(7)|ovary(1)|pancreas(1)|prostate(1)|skin(1)	23						TCTCCTTGCAGAGAGCAGGAA	0.348000													5	122					0	0	1	0	0
LPHN3	23284	broad.mit.edu	37	4	62598777	62598777	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr4:62598777C>T	ENST00000512091.1	+	7	1447	c.700C>T	c.(700-702)Cgg>Tgg	p.R234W	LPHN3_ENST00000506700.1_Missense_Mutation_p.R234W|LPHN3_ENST00000506746.1_Missense_Mutation_p.R302W|LPHN3_ENST00000514157.1_Missense_Mutation_p.R234W|LPHN3_ENST00000508946.1_Missense_Mutation_p.R234W|LPHN3_ENST00000506720.1_Missense_Mutation_p.R302W|LPHN3_ENST00000514591.1_Missense_Mutation_p.R234W|LPHN3_ENST00000514996.1_Missense_Mutation_p.R234W|LPHN3_ENST00000511324.1_Missense_Mutation_p.R302W|LPHN3_ENST00000509896.1_Missense_Mutation_p.R302W|LPHN3_ENST00000504896.1_Missense_Mutation_p.R234W|LPHN3_ENST00000508693.1_Missense_Mutation_p.R302W|LPHN3_ENST00000545650.1_Missense_Mutation_p.R234W|LPHN3_ENST00000507625.1_Missense_Mutation_p.R302W|LPHN3_ENST00000507164.1_Missense_Mutation_p.R302W			Q9HAR2	LPHN3_HUMAN	latrophilin 3	234	Olfactomedin-like.				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|sugar binding	p.R234W(3)		breast(5)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(5)|kidney(4)|large_intestine(21)|lung(73)|ovary(1)|pancreas(1)|prostate(6)|upper_aerodigestive_tract(1)	125						GTTTGATTTGCGGACTAGGAT	0.468000													5	40					0	0	1	0	0
FGF23	8074	broad.mit.edu	37	12	4479668	4479668	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr12:4479668C>T	ENST00000237837.1	-	3	742	c.597G>A	c.(595-597)atG>atA	p.M199I		NM_020638.2	NP_065689.1	Q9GZV9	FGF23_HUMAN	fibroblast growth factor 23	199					cell differentiation|insulin receptor signaling pathway|negative regulation of bone mineralization|negative regulation of hormone secretion|negative regulation of osteoblast differentiation|positive regulation of vitamin D 24-hydroxylase activity|regulation of phosphate transport|vitamin D catabolic process	extracellular space	growth factor activity			NS(1)|breast(2)|kidney(1)|large_intestine(1)|lung(7)|ovary(2)|pancreas(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)	22			Colorectal(7;0.00165)|COAD - Colon adenocarcinoma(12;0.0229)|STAD - Stomach adenocarcinoma(119;0.206)			GGGCCGGGGTCATCCGGGCCC	0.682000													5	49					0	0	1	0	0
TMBIM1	64114	broad.mit.edu	37	2	219144753	219144753	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr2:219144753C>T	ENST00000444881.1	-	4	1024	c.299G>A	c.(298-300)cGa>cAa	p.R100Q	PNKD_ENST00000472650.1_Intron|TMBIM1_ENST00000258412.3_Missense_Mutation_p.R100Q|TMBIM1_ENST00000396809.2_Missense_Mutation_p.R100Q|PNKD_ENST00000273077.4_Intron|TMBIM1_ENST00000445635.1_5'UTR			Q969X1	TMBI1_HUMAN	transmembrane BAX inhibitor motif containing 1	100						integral to membrane				NS(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(2)	9		Renal(207;0.0474)		Epithelial(149;8.56e-07)|all cancers(144;0.000154)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		TCTTACCTTTCGGATAAAAGT	0.587000													7	85					0	0	1	0	0
FANCI	55215	broad.mit.edu	37	15	89844556	89844556	+	Splice_Site	SNP	G	G	A			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr15:89844556G>A	ENST00000310775.7	+	27	2975		c.e27-1		FANCI_ENST00000300027.8_Splice_Site	NM_001113378.1	NP_001106849.1	Q9NVI1	FANCI_HUMAN	Fanconi anemia, complementation group I						cell cycle|DNA repair	nucleoplasm	protein binding			breast(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(7)|ovary(2)|pancreas(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	31	Lung NSC(78;0.0472)|all_lung(78;0.089)					TCCTTTCTCAGAGGTCCTTGT	0.443000								Involved in tolerance or repair of DNA crosslinks	Fanconi Anemia				7	106					0	0	1	0	0
OS9	10956	broad.mit.edu	37	12	58114262	58114262	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr12:58114262G>T	ENST00000315970.7	+	14	1880	c.1839G>T	c.(1837-1839)gaG>gaT	p.E613D	OS9_ENST00000552285.1_Missense_Mutation_p.E558D|OS9_ENST00000439210.2_Missense_Mutation_p.E484D|RP11-571M6.7_ENST00000549477.1_RNA|OS9_ENST00000389146.6_Missense_Mutation_p.E598D|OS9_ENST00000413095.2_Missense_Mutation_p.E352D|OS9_ENST00000389142.5_Missense_Mutation_p.E543D|OS9_ENST00000435406.2_Missense_Mutation_p.E506D|OS9_ENST00000551035.1_Missense_Mutation_p.E526D|OS9_ENST00000257966.8_Missense_Mutation_p.E559D	NM_001017958.2|NM_006812.3	NP_001017958.1|NP_006803.1	Q13438	OS9_HUMAN	osteosarcoma amplified 9, endoplasmic reticulum lectin	613					ER-associated protein catabolic process|protein retention in ER lumen|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to endoplasmic reticulum stress	endoplasmic reticulum lumen|Hrd1p ubiquitin ligase complex	glycoprotein binding|protein binding|sugar binding			autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(2)|large_intestine(4)|lung(8)|ovary(2)|prostate(1)|urinary_tract(1)	21	all_neural(12;0.00548)|Glioma(12;0.0126)|Melanoma(17;0.122)		BRCA - Breast invasive adenocarcinoma(9;0.109)			TGACTGATGAGGACACGAGAA	0.542000													6	54					0.0215528	0.0216329	1	1	0
KRT27	342574	broad.mit.edu	37	17	38936044	38936044	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr17:38936044C>G	ENST00000301656.3	-	4	794	c.754G>C	c.(754-756)Gac>Cac	p.D252H		NM_181537.3	NP_853515.2	Q7Z3Y8	K1C27_HUMAN	keratin 27	252	Linker 12.|Rod.					cytoplasm|intermediate filament	structural molecule activity			NS(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(6)|ovary(1)|prostate(3)|skin(1)|stomach(1)	21		Breast(137;0.000812)				ACCGTGAGGTCTACCCCGGGG	0.537000													4	60					0	0	1	0	0
MASTL	84930	broad.mit.edu	37	10	27459638	27459638	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr10:27459638G>A	ENST00000375946.4	+	8	2353	c.1750G>A	c.(1750-1752)Gaa>Aaa	p.E584K	MASTL_ENST00000375940.4_Missense_Mutation_p.E584K|MASTL_ENST00000477034.1_3'UTR|MASTL_ENST00000342386.6_Missense_Mutation_p.E584K	NM_001172303.1|NM_032844.3	NP_001165774.1|NP_116233.2	Q96GX5	GWL_HUMAN	microtubule associated serine/threonine kinase-like	584	Protein kinase.				cell division|G2/M transition of mitotic cell cycle|mitosis|negative regulation of protein phosphatase type 2A activity|regulation of cell cycle|response to DNA damage stimulus	centrosome|cleavage furrow|nucleus	ATP binding|protein phosphatase 2A binding|protein serine/threonine kinase activity			breast(3)|cervix(2)|endometrium(2)|large_intestine(7)|lung(9)|ovary(1)|pancreas(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29						AAGTCCATTAGAAAGTCAGCC	0.318000													4	97					0	0	1	0	0
NLN	57486	broad.mit.edu	37	5	65084006	65084006	+	Silent	SNP	G	G	A			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr5:65084006G>A	ENST00000380985.5	+	8	1198	c.1020G>A	c.(1018-1020)ttG>ttA	p.L340L	NLN_ENST00000502464.1_Silent_p.L236L	NM_020726.4	NP_065777.1	Q9BYT8	NEUL_HUMAN	neurolysin (metallopeptidase M3 family)	340					proteolysis	mitochondrial intermembrane space	metal ion binding|metalloendopeptidase activity			central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(4)|lung(10)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	26		Lung NSC(167;7.21e-05)|Prostate(74;0.0174)|Ovarian(174;0.186)		UCEC - Uterine corpus endometrioid carcinoma (4;0.0743)|Lung(70;0.00616)		TTTTGAATTTGAAGAAAAAGG	0.358000													11	142					0	0	1	0	0
ZNFX1	57169	broad.mit.edu	37	20	47886750	47886750	+	Silent	SNP	C	C	T			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr20:47886750C>T	ENST00000396105.1	-	3	1845	c.1599G>A	c.(1597-1599)caG>caA	p.Q533Q	ZNFX1_ENST00000371754.4_Silent_p.Q533Q|ZNFX1_ENST00000371752.1_Silent_p.Q533Q	NM_021035.2	NP_066363.1	Q9P2E3	ZNFX1_HUMAN	zinc finger, NFX1-type containing 1	533							metal ion binding			cervix(2)|endometrium(8)|kidney(7)|large_intestine(15)|liver(1)|lung(17)|ovary(2)|prostate(4)|skin(3)|urinary_tract(1)	60			BRCA - Breast invasive adenocarcinoma(12;0.00173)|COAD - Colon adenocarcinoma(4;0.14)|Colorectal(8;0.166)			CGATATTCCTCTGGAAGGGAA	0.502000													11	108					0	0	1	0	0
GPR124	25960	broad.mit.edu	37	8	37691311	37691311	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr8:37691311C>T	ENST00000315215.7	+	10	1765	c.1402C>T	c.(1402-1404)Cag>Tag	p.Q468*	GPR124_ENST00000412232.2_Nonsense_Mutation_p.Q468*			Q96PE1	GP124_HUMAN	G protein-coupled receptor 124	468					central nervous system development|endothelial cell migration|neuropeptide signaling pathway|regulation of angiogenesis|regulation of chemotaxis|sprouting angiogenesis	integral to membrane|plasma membrane	G-protein coupled receptor activity			central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(4)|lung(16)|ovary(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	37			BRCA - Breast invasive adenocarcinoma(5;2.75e-24)|LUSC - Lung squamous cell carcinoma(8;3.5e-10)			CTATGTGGCTCAGATGATCCA	0.527000													5	73					0	0	1	0	0
GFAP	2670	broad.mit.edu	37	17	42987581	42987581	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr17:42987581G>C	ENST00000435360.2	-	8	1226	c.1219C>G	c.(1219-1221)Ctc>Gtc	p.L407V	GFAP_ENST00000253408.5_Intron|GFAP_ENST00000588735.1_Intron	NM_001131019.2|NM_001242376.1	NP_001124491.1|NP_001229305.1	P14136	GFAP_HUMAN	glial fibrillary acidic protein	405	Tail.					cytoplasm|intermediate filament	structural constituent of cytoskeleton			endometrium(3)|kidney(1)|large_intestine(2)|liver(1)|lung(11)|ovary(1)|pancreas(1)|skin(2)|urinary_tract(1)	23		Prostate(33;0.0959)				AGGCTTTTGAGATATCTTGTG	0.483000													10	178					0	0	1	0	0
GPAM	57678	broad.mit.edu	37	10	113928627	113928627	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr10:113928627C>T	ENST00000348367.4	-	10	1075	c.878G>A	c.(877-879)aGa>aAa	p.R293K	GPAM_ENST00000423155.1_Missense_Mutation_p.R293K|GPAM_ENST00000369425.1_Missense_Mutation_p.R293K			Q9HCL2	GPAT1_HUMAN	glycerol-3-phosphate acyltransferase, mitochondrial	293					phospholipid biosynthetic process|triglyceride biosynthetic process	integral to membrane|mitochondrial outer membrane	glycerol-3-phosphate O-acyltransferase activity			breast(2)|central_nervous_system(2)|endometrium(8)|kidney(2)|large_intestine(5)|lung(8)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	31				Epithelial(162;0.0306)|all cancers(201;0.123)		GAGCAAAGCTCTATAGAGAAC	0.408000													4	85					0	0	1	0	0
GTPBP1	9567	broad.mit.edu	37	22	39112877	39112877	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr22:39112877G>C	ENST00000216044.5	+	4	939	c.706G>C	c.(706-708)Gag>Cag	p.E236Q		NM_004286.4	NP_004277.2	O00178	GTPB1_HUMAN	GTP binding protein 1	236					immune response|positive regulation of mRNA catabolic process|signal transduction	cytoplasmic exosome (RNase complex)|cytosol	GTP binding|GTPase activity			endometrium(2)|large_intestine(3)|lung(9)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(1)	18	Melanoma(58;0.04)					CGGCAGCCTGGAGTGGACCAA	0.517000													5	132					0	0	1	0	0
HOOK2	29911	broad.mit.edu	37	19	12874125	12874125	+	Silent	SNP	G	G	A			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr19:12874125G>A	ENST00000264827.5	-	22	2295	c.2125C>T	c.(2125-2127)Ctg>Ttg	p.L709L	HOOK2_ENST00000397668.3_Silent_p.L711L	NM_001100176.1	NP_001093646.1	Q96ED9	HOOK2_HUMAN	hook microtubule-tethering protein 2	711	Required for localization to the centrosome and induction of aggresome formation.|Sufficient for interaction with CEP110.				early endosome to late endosome transport|endocytosis|endosome organization|endosome to lysosome transport|lysosome organization|microtubule cytoskeleton organization|protein transport	centrosome|FHF complex|microtubule	identical protein binding|microtubule binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(7)|ovary(1)|prostate(5)|skin(1)	20						CGAAGGTTCAGAGATGCCAGG	0.647000													6	65					0	0	1	0	0
GCNT4	51301	broad.mit.edu	37	5	74325489	74325489	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr5:74325489G>A	ENST00000322348.4	-	1	1235	c.374C>T	c.(373-375)tCa>tTa	p.S125L		NM_016591.2	NP_057675.1	Q9P109	GCNT4_HUMAN	glucosaminyl (N-acetyl) transferase 4, core 2	125					protein O-linked glycosylation	Golgi membrane|integral to membrane	beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity|N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity			NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(3)|ovary(2)|skin(1)|stomach(2)	19		all_lung(232;0.0131)|Lung NSC(167;0.0282)|Ovarian(174;0.0798)		OV - Ovarian serous cystadenocarcinoma(47;8.44e-57)		CTCCTCCTTTGAGACAAGCTT	0.403000													11	141					0	0	1	0	0
C9orf84	158401	broad.mit.edu	37	9	114538159	114538159	+	Silent	SNP	G	G	A			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr9:114538159G>A	ENST00000374287.3	-	5	422	c.162C>T	c.(160-162)gtC>gtT	p.V54V	C9orf84_ENST00000318737.4_Silent_p.V54V|C9orf84_ENST00000374283.5_Silent_p.V118V			Q5VXU9	CI084_HUMAN	chromosome 9 open reading frame 84	54										breast(1)|cervix(1)|endometrium(3)|kidney(7)|large_intestine(10)|liver(1)|lung(7)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	35						TGTATAAACTGACCTCCTCTA	0.373000													7	101					0	0	1	0	0
OR5A2	219981	broad.mit.edu	37	11	59190019	59190019	+	Silent	SNP	G	G	A			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr11:59190019G>A	ENST00000302040.4	-	1	430	c.408C>T	c.(406-408)ctC>ctT	p.L136L		NM_001001954.1	NP_001001954.1	Q8NGI9	OR5A2_HUMAN	olfactory receptor, family 5, subfamily A, member 2	136					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(3)|liver(1)|lung(15)|skin(1)|upper_aerodigestive_tract(1)	21						TATGGGATATGAGGACTGTGT	0.458000													6	68					0	0	1	0	0
KNTC1	9735	broad.mit.edu	37	12	123069497	123069497	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr12:123069497C>T	ENST00000333479.7	+	36	3671	c.3494C>T	c.(3493-3495)tCc>tTc	p.S1165F	KNTC1_ENST00000450485.2_Intron	NM_014708.4	NP_055523.1	P50748	KNTC1_HUMAN	kinetochore associated 1	1165					cell division|mitotic cell cycle checkpoint|mitotic prometaphase|protein complex assembly|regulation of exit from mitosis	condensed chromosome kinetochore|cytosol|kinetochore microtubule|nucleus|spindle pole	protein binding			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(12)|kidney(8)|large_intestine(12)|lung(20)|ovary(7)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(4)	72	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;7.21e-05)|Epithelial(86;0.000178)|BRCA - Breast invasive adenocarcinoma(302;0.217)		GTAGAGCTTTCCAGACAATGC	0.328000													4	53					0	0	1	0	0
GOLT1A	127845	broad.mit.edu	37	1	204170841	204170841	+	Silent	SNP	C	C	T			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr1:204170841C>T	ENST00000308302.3	-	3	401	c.216G>A	c.(214-216)ctG>ctA	p.L72L		NM_198447.1	NP_940849.1	Q6ZVE7	GOT1A_HUMAN	golgi transport 1A	72					protein transport|vesicle-mediated transport	Golgi membrane|integral to membrane				kidney(1)|lung(2)|urinary_tract(1)	4	all_cancers(21;0.0165)|Breast(84;0.179)|all_epithelial(62;0.242)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|BRCA - Breast invasive adenocarcinoma(75;0.0833)|Kidney(21;0.0934)|Epithelial(59;0.244)			CCACACCCCCCAGGAGGAAGC	0.537000													6	129					0	0	1	0	0
DNAH2	146754	broad.mit.edu	37	17	7663189	7663189	+	Silent	SNP	C	C	T			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr17:7663189C>T	ENST00000572933.1	+	17	4178	c.2718C>T	c.(2716-2718)gtC>gtT	p.V906V	DNAH2_ENST00000389173.2_Silent_p.V906V			Q9P225	DYH2_HUMAN	dynein, axonemal, heavy chain 2	906	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(3)|breast(11)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(2)|kidney(16)|large_intestine(53)|liver(2)|lung(49)|ovary(7)|prostate(7)|skin(15)|upper_aerodigestive_tract(1)|urinary_tract(1)	189		all_cancers(10;4.66e-07)|Prostate(122;0.081)				CCATCTCTGTCTTCTGCCACC	0.542000													14	256					0	0	1	0	0
POLR3E	55718	broad.mit.edu	37	16	22320778	22320778	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr16:22320778C>T	ENST00000299853.5	+	6	478	c.311C>T	c.(310-312)tCt>tTt	p.S104F	POLR3E_ENST00000359210.4_Missense_Mutation_p.S104F|POLR3E_ENST00000564209.1_Missense_Mutation_p.S104F|POLR3E_ENST00000418581.2_Missense_Mutation_p.S68F|POLR3E_ENST00000564256.1_3'UTR	NM_001258033.1|NM_001258035.1|NM_018119.3	NP_001244962.1|NP_001244964.1|NP_060589.1	Q9NVU0	RPC5_HUMAN	polymerase (RNA) III (DNA directed) polypeptide E (80kD)	104					innate immune response|response to virus|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase III promoter	nucleoplasm	DNA-directed RNA polymerase activity			central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(7)|lung(10)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	27				GBM - Glioblastoma multiforme(48;0.012)		ACCTTCTGCTCTTCCCAGACC	0.637000													5	381					0	0	1	0	0
CAMK2D	817	broad.mit.edu	37	4	114381309	114381309	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr4:114381309C>G	ENST00000454265.2	-	18	2131	c.1273G>C	c.(1273-1275)Gaa>Caa	p.E425Q	CAMK2D_ENST00000508738.1_Missense_Mutation_p.E411Q|CAMK2D_ENST00000429180.1_Missense_Mutation_p.E420Q|CAMK2D_ENST00000514328.1_Missense_Mutation_p.E399Q|CAMK2D_ENST00000394524.3_Missense_Mutation_p.E400Q|CAMK2D_ENST00000394522.3_Missense_Mutation_p.E414Q|CAMK2D_ENST00000505990.1_Missense_Mutation_p.E434Q|CAMK2D_ENST00000394526.2_Missense_Mutation_p.E411Q|CAMK2D_ENST00000515496.1_Missense_Mutation_p.E411Q|CAMK2D_ENST00000379773.2_Missense_Mutation_p.E400Q|CAMK2D_ENST00000418639.2_Missense_Mutation_p.E414Q|CAMK2D_ENST00000511664.1_Missense_Mutation_p.E434Q|CAMK2D_ENST00000296402.5_Missense_Mutation_p.E400Q|CAMK2D_ENST00000342666.5_Missense_Mutation_p.E400Q			Q13557	KCC2D_HUMAN	calcium/calmodulin-dependent protein kinase II delta	400					interferon-gamma-mediated signaling pathway|regulation of cell growth|synaptic transmission	calcium- and calmodulin-dependent protein kinase complex|cytosol|endocytic vesicle membrane|nucleoplasm|plasma membrane	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(3)|ovary(1)|prostate(1)	13		Ovarian(17;0.00369)|Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.000271)		GTACCATTTTCAAAGTAGAAT	0.343000													5	108					0	0	1	0	0
PLEKHG2	64857	broad.mit.edu	37	19	39912806	39912806	+	Missense_Mutation	SNP	T	T	G			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr19:39912806T>G	ENST00000425673.1	+	15	1793	c.1468T>G	c.(1468-1470)Tca>Gca	p.S490A	PLEKHG2_ENST00000409794.3_Missense_Mutation_p.S519A|PLEKHG2_ENST00000458508.2_Missense_Mutation_p.S460A|PLEKHG2_ENST00000378550.1_Missense_Mutation_p.S519A|PLEKHG2_ENST00000409797.2_Missense_Mutation_p.S519A			Q9H7P9	PKHG2_HUMAN	pleckstrin homology domain containing, family G (with RhoGef domain) member 2	519					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity			breast(3)|central_nervous_system(1)|endometrium(8)|kidney(2)|large_intestine(2)|liver(1)|lung(13)|pancreas(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	40	all_cancers(60;3.08e-07)|all_lung(34;2.66e-08)|Lung NSC(34;3e-08)|all_epithelial(25;6.57e-07)|Ovarian(47;0.0569)		Epithelial(26;2.92e-26)|all cancers(26;2.01e-23)|Lung(45;0.000499)|LUSC - Lung squamous cell carcinoma(53;0.000657)			GCCACCAGTTTCAGGCTCTGC	0.572000													4	27					0	0	1	0	0
LMBR1L	55716	broad.mit.edu	37	12	49498291	49498291	+	Silent	SNP	G	G	A			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr12:49498291G>A	ENST00000267102.8	-	5	717	c.375C>T	c.(373-375)atC>atT	p.I125I	LMBR1L_ENST00000395141.4_Silent_p.I120I|LMBR1L_ENST00000547382.1_Silent_p.I125I|LMBR1L_ENST00000553204.1_Intron	NM_018113.2	NP_060583.2	Q6UX01	LMBRL_HUMAN	limb development membrane protein 1-like	125					endocytosis	integral to membrane|plasma membrane	receptor activity			endometrium(2)|kidney(2)|large_intestine(1)|lung(5)|pancreas(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	15						GCATGAGGAAGATGAGGGACA	0.498000													8	120					0	0	1	0	0
MYO1H	283446	broad.mit.edu	37	12	109834318	109834318	+	Silent	SNP	G	G	A			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr12:109834318G>A	ENST00000310903.5	+	4	478	c.372G>A	c.(370-372)gtG>gtA	p.V124V	MYO1H_ENST00000431443.2_Silent_p.V124V			B4DNW6	B4DNW6_HUMAN	myosin IH	0						myosin complex	motor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(17)|prostate(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	47						ATTTTGCAGTGACCTGCCCAA	0.493000													4	54					0	0	1	0	0
DNMT1	1786	broad.mit.edu	37	19	10257201	10257201	+	Splice_Site	SNP	C	C	G	rs9676676		TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr19:10257201C>G	ENST00000340748.4	-	27	2908		c.e27-1		DNMT1_ENST00000359526.4_Splice_Site|DNMT1_ENST00000540357.1_Splice_Site			P26358	DNMT1_HUMAN	DNA (cytosine-5-)-methyltransferase 1						chromatin modification|maintenance of DNA methylation|negative regulation of histone H3-K9 methylation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of gene expression|positive regulation of histone H3-K4 methylation|transcription, DNA-dependent	nucleus	DNA (cytosine-5-)-methyltransferase activity|DNA binding|transcription factor binding			breast(5)|endometrium(8)|kidney(5)|large_intestine(21)|lung(11)|ovary(2)|pancreas(1)|prostate(10)|skin(5)|stomach(1)|urinary_tract(1)	70			OV - Ovarian serous cystadenocarcinoma(20;1.59e-09)|Epithelial(33;2.86e-06)|all cancers(31;6.68e-06)		Azacitidine(DB00928)|Decitabine(DB01262)|Flucytosine(DB01099)|Ifosfamide(DB01181)|Procainamide(DB01035)	CACACAGAATCTGAAGGAAAC	0.562000													5	90					0	0	1	0	0
PDZRN3	23024	broad.mit.edu	37	3	73433958	73433958	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr3:73433958C>G	ENST00000263666.4	-	10	1873	c.1759G>C	c.(1759-1761)Gag>Cag	p.E587Q	PDZRN3_ENST00000535920.1_Missense_Mutation_p.E309Q|PDZRN3_ENST00000466780.1_Missense_Mutation_p.E244Q|PDZRN3_ENST00000479530.1_Missense_Mutation_p.E304Q|PDZRN3_ENST00000462146.2_Missense_Mutation_p.E244Q	NM_015009.1	NP_055824.1	Q9UPQ7	PZRN3_HUMAN	PDZ domain containing ring finger 3	587							ubiquitin-protein ligase activity|zinc ion binding			breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(13)|lung(31)|ovary(4)|pancreas(2)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	69		Prostate(10;0.114)|Lung NSC(201;0.187)|Lung SC(41;0.236)		BRCA - Breast invasive adenocarcinoma(55;0.00041)|Epithelial(33;0.0023)|LUSC - Lung squamous cell carcinoma(21;0.0048)|Lung(16;0.0105)|KIRC - Kidney renal clear cell carcinoma(39;0.111)|Kidney(39;0.134)		CCATTGTTCTCTTGCTCCGAG	0.637000													4	63					0	0	1	0	0
HOXB1	3211	broad.mit.edu	37	17	46607143	46607143	+	Silent	SNP	G	G	A			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr17:46607143G>A	ENST00000239174.6	-	2	764	c.672C>T	c.(670-672)ttC>ttT	p.F224F	HOXB1_ENST00000577092.1_3'UTR	NM_002144.3	NP_002135.2	P14653	HXB1_HUMAN	homeobox B1	224						nucleus	protein domain specific binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(2)|lung(18)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	30						GGTACTTGTTGAAATGGAACT	0.577000													11	203					0	0	1	0	0
WSCD2	9671	broad.mit.edu	37	12	108589738	108589738	+	Silent	SNP	C	C	T			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr12:108589738C>T	ENST00000332082.4	+	3	947	c.129C>T	c.(127-129)ccC>ccT	p.P43P	WSCD2_ENST00000261400.3_Silent_p.P43P|WSCD2_ENST00000549903.1_Silent_p.P43P|WSCD2_ENST00000547525.1_Silent_p.P43P			Q2TBF2	WSCD2_HUMAN	WSC domain containing 2	43						integral to membrane				breast(4)|endometrium(3)|kidney(1)|large_intestine(16)|liver(2)|lung(23)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	57						TGGGCCAGCCCGCTGTCTCGG	0.612000													8	137					0	0	1	0	0
ZNF214	7761	broad.mit.edu	37	11	7022032	7022032	+	Silent	SNP	C	C	T			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr11:7022032C>T	ENST00000278314.4	-	3	1197	c.882G>A	c.(880-882)caG>caA	p.Q294Q	ZNF214_ENST00000536068.1_Silent_p.Q294Q	NM_013249.2	NP_037381.2	Q9UL59	ZN214_HUMAN	zinc finger protein 214	294					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|lung(10)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	29				Epithelial(150;3.87e-08)|BRCA - Breast invasive adenocarcinoma(625;0.081)		TGTGAACTCTCTGATGAAAGT	0.433000													14	211					0	0	1	0	0
MINK1	50488	broad.mit.edu	37	17	4798511	4798511	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr17:4798511C>T	ENST00000355280.6	+	25	3255	c.3059C>T	c.(3058-3060)tCc>tTc	p.S1020F	MINK1_ENST00000347992.7_Missense_Mutation_p.S991F|MINK1_ENST00000453408.3_Missense_Mutation_p.S1000F	NM_001024937.3|NM_015716.4|NM_153827.4	NP_001020108.1|NP_056531.1|NP_722549.2	Q8N4C8	MINK1_HUMAN	misshapen-like kinase 1	1020	CNH.|Mediates interaction with RAP2A.				JNK cascade	cytoplasm	ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			central_nervous_system(2)|large_intestine(1)|lung(1)|skin(1)|stomach(1)	6						CGATTCAACTCCGAGATCCTC	0.597000													6	262					0	0	1	0	0
SLC25A6	293	broad.mit.edu	37	X	1508295	1508295	+	Missense_Mutation	SNP	C	C	G	rs143851976		TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chrX:1508295C>G	ENST00000381401.5	-	2	1151	c.437G>C	c.(436-438)gGa>gCa	p.G146A	SLC25A6_ENST00000475167.1_5'UTR	NM_001636.3	NP_001627.2	P12236	ADT3_HUMAN	solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6	146					active induction of host immune response by virus|apoptosis|energy reserve metabolic process|regulation of insulin secretion|viral infectious cycle	integral to membrane|mitochondrial inner membrane presequence translocase complex	ATP:ADP antiporter activity|protein binding			haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(8)|upper_aerodigestive_tract(1)	11		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)			Clodronate(DB00720)	GCCTGACTTTCCCACGTCCGC	0.667000													7	218					0	0	1	0	0
OR5H1	26341	broad.mit.edu	37	3	97852033	97852033	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr3:97852033C>G	ENST00000354565.2	+	1	492	c.492C>G	c.(490-492)ttC>ttG	p.F164L	RP11-343D2.11_ENST00000508964.1_RNA	NM_001005338.1	NP_001005338.1	A6NKK0	OR5H1_HUMAN	olfactory receptor, family 5, subfamily H, member 1	164					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(7)|kidney(8)|large_intestine(3)|lung(13)|ovary(1)|skin(1)	34						GATTTTTATTCAGACTAACCT	0.343000													6	184					0	0	1	0	0
CXXC5	51523	broad.mit.edu	37	5	139061005	139061005	+	Silent	SNP	C	C	G			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr5:139061005C>G	ENST00000302517.3	+	2	1611	c.897C>G	c.(895-897)ctC>ctG	p.L299L	CXXC5_ENST00000515038.1_3'UTR|CXXC5_ENST00000511048.1_Silent_p.L299L	NM_016463.7	NP_057547.5	Q7LFL8	CXXC5_HUMAN	CXXC finger protein 5	299					positive regulation of I-kappaB kinase/NF-kappaB cascade	cytoplasm|nucleus	DNA binding|signal transducer activity|zinc ion binding			central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(7)|upper_aerodigestive_tract(1)	12			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GTGAGGAACTCAAAAAGAAGC	0.567000													5	156					0	0	1	0	0
MSI2	124540	broad.mit.edu	37	17	55339539	55339539	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr17:55339539C>T	ENST00000284073.2	+	5	507	c.298C>T	c.(298-300)Cga>Tga	p.R100*	MSI2_ENST00000416426.2_Nonsense_Mutation_p.R78*|MSI2_ENST00000322684.3_Nonsense_Mutation_p.R96*	NM_138962.2	NP_620412.1	Q96DH6	MSI2H_HUMAN	musashi RNA-binding protein 2	100	RRM 1.					cytoplasm	nucleotide binding|RNA binding			central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|ovary(1)|pancreas(1)|skin(1)	7	Breast(9;1.78e-08)			GBM - Glioblastoma multiforme(1;0.0025)		ATTTCCTCGTCGAGCGCAACC	0.358000			T	HOXA9	CML								10	126					0	0	1	0	0
C3	718	broad.mit.edu	37	19	6694573	6694573	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr19:6694573G>A	ENST00000245907.6	-	24	3115	c.3023C>T	c.(3022-3024)tCg>tTg	p.S1008L		NM_000064.2	NP_000055.2	P01024	CO3_HUMAN	complement component 3	1008					complement activation, alternative pathway|complement activation, classical pathway|G-protein coupled receptor protein signaling pathway|inflammatory response|positive regulation vascular endothelial growth factor production	extracellular space	endopeptidase inhibitor activity|receptor binding			breast(5)|endometrium(7)|kidney(6)|large_intestine(18)|liver(1)|lung(18)|ovary(1)|pancreas(1)|prostate(5)|skin(7)|upper_aerodigestive_tract(3)	72				GBM - Glioblastoma multiforme(1328;1.36e-05)|Lung(535;0.00661)		CCCGCAGCCCGAGGGGGTCAC	0.607000													7	77					0	0	1	0	0
CNTN3	5067	broad.mit.edu	37	3	74411183	74411183	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr3:74411183G>A	ENST00000263665.6	-	10	1249	c.1222C>T	c.(1222-1224)Cca>Tca	p.P408S		NM_020872.1	NP_065923.1	Q9P232	CNTN3_HUMAN	contactin 3 (plasmacytoma associated)	408	Ig-like C2-type 5.				cell adhesion	anchored to membrane|plasma membrane	protein binding			NS(2)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(39)|ovary(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	83		Lung NSC(201;0.138)|Lung SC(41;0.21)		Epithelial(33;0.00212)|BRCA - Breast invasive adenocarcinoma(55;0.00258)|LUSC - Lung squamous cell carcinoma(21;0.00461)|Lung(16;0.01)		GAAAAATCTGGAGCAGAAGCT	0.433000													6	60					0	0	1	0	0
GMPS	8833	broad.mit.edu	37	3	155628611	155628611	+	Silent	SNP	G	G	A			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr3:155628611G>A	ENST00000496455.1	+	6	992	c.657G>A	c.(655-657)gtG>gtA	p.V219V	GMPS_ENST00000295920.7_Silent_p.V120V	NM_003875.2	NP_003866.1	P49915	GUAA_HUMAN	guanine monphosphate synthase	219					glutamine metabolic process|purine base biosynthetic process	cytosol	ATP binding|GMP synthase (glutamine-hydrolyzing) activity|GMP synthase activity			breast(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(5)|lung(12)|ovary(2)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	32			Lung(72;0.11)|LUSC - Lung squamous cell carcinoma(72;0.114)		L-Glutamic Acid(DB00142)|L-Glutamine(DB00130)	CCTTCACCGTGCAGAACAGAG	0.388000			T	MLL	AML								11	73					0	0	1	0	0
LYZL6	57151	broad.mit.edu	37	17	34266358	34266358	+	Translation_Start_Site	SNP	C	C	T			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr17:34266358C>T	ENST00000585556.1	-	2	337	c.3G>A	c.(1-3)atG>atA	p.M1I	LYZL6_ENST00000293274.4_Start_Codon_SNP_p.M1I|LYZL6_ENST00000394523.3_Start_Codon_SNP_p.M1I			O75951	LYZL6_HUMAN	lysozyme-like 6	1					cell wall macromolecule catabolic process	extracellular region	lysozyme activity			breast(1)|endometrium(1)|large_intestine(1)|lung(8)|stomach(1)	12				UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		GCGCCTTTGTCATCCTTGGAG	0.557000													6	147					0	0	1	0	0
BTN2A2	10385	broad.mit.edu	37	6	26393159	26393159	+	Silent	SNP	G	G	A			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr6:26393159G>A	ENST00000356709.4	+	8	1647	c.1536G>A	c.(1534-1536)ctG>ctA	p.L512L	BTN2A2_ENST00000482536.1_Silent_p.L302L|BTN2A2_ENST00000469230.1_Intron|BTN2A2_ENST00000416795.2_Silent_p.L512L|BTN2A2_ENST00000432533.2_3'UTR|BTN2A2_ENST00000352867.2_Silent_p.L396L	NM_001197240.1|NM_006995.4	NP_001184169.1|NP_008926.2	Q8WVV5	BT2A2_HUMAN	butyrophilin, subfamily 2, member A2	512					negative regulation of activated T cell proliferation|negative regulation of cellular metabolic process|negative regulation of cytokine secretion	integral to membrane				breast(2)|endometrium(3)|large_intestine(5)|lung(13)	23						AAGAGGGCCTGAAACTTCACA	0.562000													5	53					0	0	1	0	0
OR4N5	390437	broad.mit.edu	37	14	20612771	20612771	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr14:20612771G>A	ENST00000333629.1	+	1	877	c.877G>A	c.(877-879)Gag>Aag	p.E293K		NM_001004724.1	NP_001004724.1	Q8IXE1	OR4N5_HUMAN	olfactory receptor, family 4, subfamily N, member 5	293					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|lung(23)|ovary(1)|skin(2)|urinary_tract(1)	29	all_cancers(95;0.00108)		Epithelial(56;7.58e-07)|all cancers(55;3.84e-06)	GBM - Glioblastoma multiforme(265;0.0143)		TCGCAACCAGGAGGTGAAAGC	0.413000													10	151					0	0	1	0	0
OR2M3	127062	broad.mit.edu	37	1	248366390	248366390	+	Silent	SNP	C	C	T	rs139852822	byFrequency	TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr1:248366390C>T	ENST00000456743.1	+	1	59	c.21C>T	c.(19-21)acC>acT	p.T7T		NM_001004689.1	NP_001004689.1	Q8NG83	OR2M3_HUMAN	olfactory receptor, family 2, subfamily M, member 3	7					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(6)|large_intestine(4)|lung(33)|ovary(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	50	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			AGAATTCGACCTTCAACTCCG	0.448000													15	202					0	0	1	0	0
KMT2C	58508	broad.mit.edu	37	7	151851163	151851163	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr7:151851163G>A	ENST00000355193.2	-	49	12597	c.12379C>T	c.(12379-12381)Cct>Tct	p.P4127S	KMT2C_ENST00000485241.1_5'UTR|KMT2C_ENST00000262189.6_Missense_Mutation_p.P4070S					lysine (K)-specific methyltransferase 2C																		TTTGGGGAAGGACCAAAAGGT	0.368000													12	93					0	0	1	0	0
FMN1	342184	broad.mit.edu	37	15	33261005	33261005	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr15:33261005G>A	ENST00000334528.9	-	4	2227	c.2228C>T	c.(2227-2229)tCt>tTt	p.S743F	FMN1_ENST00000561249.1_Missense_Mutation_p.S868F|FMN1_ENST00000559047.1_Missense_Mutation_p.S966F	NM_001103184.2	NP_001096654.1	Q68DA7	FMN1_HUMAN	formin 1	966	Mediates interaction with alpha-catenin (By similarity).				actin cytoskeleton organization	actin cytoskeleton|adherens junction|cytoplasm|nucleus	actin binding			endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(3)|lung(14)|ovary(2)|prostate(1)|upper_aerodigestive_tract(3)	29		all_lung(180;1.14e-07)		all cancers(64;3.05e-15)|Epithelial(43;1.67e-10)|GBM - Glioblastoma multiforme(186;4.95e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0262)		TTGACTGGAAGAAGAGCCAAG	0.552000													6	105					0	0	1	0	0
DCHS2	54798	broad.mit.edu	37	4	155254071	155254071	+	Missense_Mutation	SNP	G	G	A	rs72966165	by1000genomes	TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr4:155254071G>A	ENST00000357232.3	-	9	1791	c.1792C>T	c.(1792-1794)Ctc>Ttc	p.L598F	DCHS2_ENST00000339452.1_Missense_Mutation_p.L1097F	NM_017639.3	NP_060109.2	Q6V1P9	PCD23_HUMAN	dachsous cadherin-related 2	598	Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(3)|endometrium(8)|kidney(5)|large_intestine(54)|lung(63)|ovary(4)|pancreas(1)|prostate(14)|skin(12)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	176	all_hematologic(180;0.208)	Renal(120;0.0854)		LUSC - Lung squamous cell carcinoma(193;0.107)		ATCGGTGAGAGAGACTCACTG	0.562000													10	79					0	0	1	0	0
NPR3	4883	broad.mit.edu	37	5	32724823	32724823	+	Silent	SNP	C	C	T			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr5:32724823C>T	ENST00000265074.8	+	2	1132	c.789C>T	c.(787-789)agC>agT	p.S263S	NPR3_ENST00000415685.2_Silent_p.S47S|NPR3_ENST00000434067.2_Silent_p.S47S|NPR3_ENST00000415167.2_Silent_p.S263S	NM_000908.3|NM_001204375.1	NP_000899.1|NP_001191304.1	P17342	ANPRC_HUMAN	natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C)	263					osteoclast proliferation|positive regulation of urine volume|regulation of blood pressure|regulation of osteoblast proliferation|skeletal system development	integral to membrane	hormone binding|natriuretic peptide receptor activity			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(2)|large_intestine(5)|lung(12)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	24					Nesiritide(DB04899)	TGTGTGCGAGCAGTGACACCA	0.537000													8	53					0	0	1	0	0
FREM2	341640	broad.mit.edu	37	13	39264296	39264296	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr13:39264296G>A	ENST00000280481.7	+	1	3031	c.2815G>A	c.(2815-2817)Gaa>Aaa	p.E939K		NM_207361.4	NP_997244.3	Q5SZK8	FREM2_HUMAN	FRAS1 related extracellular matrix protein 2	939					cell communication|homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(35)|lung(39)|ovary(9)|pancreas(2)|prostate(12)|skin(11)|upper_aerodigestive_tract(7)|urinary_tract(2)	148		Lung NSC(96;1.04e-07)|Prostate(109;0.00384)|Breast(139;0.00396)|Lung SC(185;0.0565)|Hepatocellular(188;0.114)		all cancers(112;3.32e-07)|Epithelial(112;1.66e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00154)|BRCA - Breast invasive adenocarcinoma(63;0.00631)|GBM - Glioblastoma multiforme(144;0.0312)		AGTGGATGATGAAGTGCCCAT	0.493000													4	62					0	0	1	0	0
TANGO6	79613	broad.mit.edu	37	16	68909060	68909060	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr16:68909060G>A	ENST00000261778.1	+	5	1010	c.998G>A	c.(997-999)gGa>gAa	p.G333E		NM_024562.1	NP_078838.1			transport and golgi organization 6 homolog (Drosophila)																		GTGCCAGCGGGAGCAGCTGGT	0.473000													6	59					0	0	1	0	0
RSPO2	340419	broad.mit.edu	37	8	108970488	108970488	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr8:108970488C>T	ENST00000276659.5	-	5	1056	c.436G>A	c.(436-438)Gaa>Aaa	p.E146K	RSPO2_ENST00000517939.1_Missense_Mutation_p.E79K|RSPO2_ENST00000517781.1_Missense_Mutation_p.E82K|RSPO2_ENST00000378439.2_Missense_Mutation_p.E82K	NM_178565.4	NP_848660.3	Q6UXX9	RSPO2_HUMAN	R-spondin 2	146	TSP type-1.				Wnt receptor signaling pathway	extracellular region	heparin binding		EIF3E/RSPO2(6)	haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(14)|ovary(2)|pancreas(1)|prostate(1)|skin(3)	28			OV - Ovarian serous cystadenocarcinoma(57;1.55e-09)			TGACCAACTTCACATCCTTCT	0.358000													5	102					0	0	1	0	0
GCLC	2729	broad.mit.edu	37	6	53370645	53370645	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr6:53370645G>A	ENST00000229416.6	-	11	1729	c.1246C>T	c.(1246-1248)Cca>Tca	p.P416S	RP1-27K12.4_ENST00000508884.1_RNA	NM_001197115.1|NM_001498.3	NP_001184044.1|NP_001489.1	P48506	GSH1_HUMAN	glutamate-cysteine ligase, catalytic subunit	416					anti-apoptosis|cell redox homeostasis|cysteine metabolic process|glutamate metabolic process|glutathione biosynthetic process|negative regulation of transcription, DNA-dependent|regulation of blood vessel size|response to heat|response to hormone stimulus|response to oxidative stress|xenobiotic metabolic process	cytosol	ADP binding|ATP binding|coenzyme binding|glutamate binding|glutamate-cysteine ligase activity|magnesium ion binding			breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(4)|liver(1)|lung(11)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	22	Lung NSC(77;0.0137)				L-Cysteine(DB00151)|L-Glutamic Acid(DB00142)	TCTGAGTTTGGAGGAGGGGGC	0.423000													6	126					0	0	1	0	0
DDX26B	203522	broad.mit.edu	37	X	134706908	134706908	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chrX:134706908G>C	ENST00000370752.4	+	11	1790	c.1456G>C	c.(1456-1458)Gaa>Caa	p.E486Q	DDX26B_ENST00000493637.1_3'UTR	NM_182540.4	NP_872346.3	Q5JSJ4	DX26B_HUMAN	DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 26B	486										large_intestine(1)|lung(8)	9	Acute lymphoblastic leukemia(192;6.56e-05)					TAGACTGACAGAATTGAACAC	0.343000													4	50					0	0	1	0	0
CLIC1	1192	broad.mit.edu	37	6	31701363	31701363	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr6:31701363G>A	ENST00000375780.2	-	5	934	c.362C>T	c.(361-363)tCa>tTa	p.S121L	CLIC1_ENST00000375779.2_Missense_Mutation_p.S121L|CLIC1_ENST00000395892.1_Missense_Mutation_p.S121L|CLIC1_ENST00000375784.3_Missense_Mutation_p.S121L			O00299	CLIC1_HUMAN	chloride intracellular channel 1	121	GST C-terminal.				signal transduction	brush border|chloride channel complex|cytoplasm|membrane fraction|nuclear membrane|plasma membrane|soluble fraction	protein binding|voltage-gated chloride channel activity			central_nervous_system(1)|endometrium(1)|lung(3)|ovary(1)|skin(1)	7						TGCTGGGTTTGAATTCTTGAT	0.537000													5	51					0	0	1	0	0
PEX5	5830	broad.mit.edu	37	12	7344263	7344263	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr12:7344263G>A	ENST00000266563.5	+	5	598	c.415G>A	c.(415-417)Gac>Aac	p.D139N	PEX5_ENST00000266564.3_Missense_Mutation_p.D139N|PEX5_ENST00000412720.2_Missense_Mutation_p.D160N|PEX5_ENST00000545220.1_3'UTR|PEX5_ENST00000420616.2_Missense_Mutation_p.D139N|PEX5_ENST00000434354.2_Missense_Mutation_p.D154N|PEX5_ENST00000455147.2_Missense_Mutation_p.D139N	NM_001131024.1	NP_001124496.1	P50542	PEX5_HUMAN	peroxisomal biogenesis factor 5	139					protein import into peroxisome matrix, translocation|protein targeting to peroxisome|protein tetramerization|protein transport	cytosol|peroxisomal matrix|peroxisomal membrane	peroxisome matrix targeting signal-1 binding|protein C-terminus binding|protein N-terminus binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(8)|ovary(1)|prostate(1)|skin(1)	21						TAATGAGACTGACTGGTCCCA	0.463000													10	88					0	0	1	0	0
DMGDH	29958	broad.mit.edu	37	5	78359574	78359574	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr5:78359574C>T	ENST00000255189.3	-	2	166	c.138G>A	c.(136-138)tgG>tgA	p.W46*	DMGDH_ENST00000520388.1_Intron|DMGDH_ENST00000380311.4_Missense_Mutation_p.E2K|DMGDH_ENST00000540686.1_5'UTR	NM_013391.2	NP_037523.2	Q9UI17	M2GD_HUMAN	dimethylglycine dehydrogenase	46					choline metabolic process|glycine catabolic process	mitochondrial matrix	aminomethyltransferase activity|dimethylglycine dehydrogenase activity|electron carrier activity			breast(2)|endometrium(2)|kidney(2)|large_intestine(10)|liver(1)|lung(10)|ovary(2)|pancreas(1)|skin(3)|upper_aerodigestive_tract(1)	34		all_lung(232;0.000638)|Lung NSC(167;0.00173)|Ovarian(174;0.0262)|Prostate(461;0.192)		OV - Ovarian serous cystadenocarcinoma(54;6.52e-45)|Epithelial(54;5.96e-40)|all cancers(79;3.56e-35)		CTCTGTCTTTCCATTGTGTTT	0.463000													7	133					0	0	1	0	0
TTC17	55761	broad.mit.edu	37	11	43436179	43436179	+	Missense_Mutation	SNP	C	C	G	rs112155488		TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr11:43436179C>G	ENST00000039989.4	+	16	2118	c.2104C>G	c.(2104-2106)Ctg>Gtg	p.L702V	TTC17_ENST00000299240.6_Missense_Mutation_p.L702V|TTC17_ENST00000526774.1_3'UTR	NM_018259.5	NP_060729.2	Q96AE7	TTC17_HUMAN	tetratricopeptide repeat domain 17	702							binding			breast(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(7)|lung(27)|ovary(5)|prostate(3)|skin(3)	53						TTACCTTGCTCTGAAGAATAT	0.403000													13	221					0	0	1	0	0
TG	7038	broad.mit.edu	37	8	133894785	133894785	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr8:133894785G>A	ENST00000220616.4	+	7	857	c.817G>A	c.(817-819)Gaa>Aaa	p.E273K	TG_ENST00000377869.1_Missense_Mutation_p.E273K	NM_003235.4	NP_003226.4	P01266	THYG_HUMAN	thyroglobulin	273	Thyroglobulin type-1 3.				hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity	p.E273*(1)		NS(1)|breast(11)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(34)|liver(2)|lung(59)|ovary(9)|pancreas(2)|prostate(6)|skin(7)|stomach(4)|upper_aerodigestive_tract(4)|urinary_tract(8)	168	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		CACCTTCACTGAAACCACCCT	0.463000													8	210					0	0	1	0	0
RXFP2	122042	broad.mit.edu	37	13	32376538	32376538	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr13:32376538C>T	ENST00000298386.2	+	18	2332	c.2261C>T	c.(2260-2262)tCc>tTc	p.S754F	RXFP2_ENST00000380314.1_Missense_Mutation_p.S730F	NM_130806.3	NP_570718.1	Q8WXD0	RXFP2_HUMAN	relaxin/insulin-like family peptide receptor 2	754						integral to membrane|plasma membrane				cervix(1)|endometrium(2)|large_intestine(15)|lung(13)|prostate(1)|stomach(1)	33		Lung SC(185;0.0262)		all cancers(112;0.000559)|Epithelial(112;0.0017)|OV - Ovarian serous cystadenocarcinoma(117;0.0145)|BRCA - Breast invasive adenocarcinoma(63;0.0535)		AAACCAGTTTCCTAGCAATCA	0.403000													7	398					0	0	1	0	0
CEBPA	1050	broad.mit.edu	37	19	33792385	33792385	+	Silent	SNP	C	C	T			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr19:33792385C>T	ENST00000498907.2	-	1	1085	c.936G>A	c.(934-936)caG>caA	p.Q312Q	CTD-2540B15.7_ENST00000587312.1_RNA	NM_004364.3	NP_004355.2	P49715	CEBPA_HUMAN	CCAAT/enhancer binding protein (C/EBP), alpha	312					cytokine-mediated signaling pathway|generation of precursor metabolites and energy|interspecies interaction between organisms|positive regulation of transcription from RNA polymerase III promoter		sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription factor binding|transcription regulatory region DNA binding	p.Q312_K313insQ(19)|p.Q312del(3)|p.H200_K352>Q(1)|p.?(1)|p.K313fs*6(1)|p.N307_Q312del(1)|p.Q312_K313insQRNVETQQ(1)|p.Q312_K313insQQ(1)|p.K313del(1)		cervix(1)|haematopoietic_and_lymphoid_tissue(912)|lung(5)|prostate(1)|stomach(1)	920	Esophageal squamous(110;0.137)					CCAGCACCTTCTGCTGCGTCT	0.647000			"""Mis, N, F"""		"""AML, MDS"""				Acute Myeloid Leukemia, Familial, associated with CEBPA germline mutation				6	81					0	0	1	0	0
CHD3	1107	broad.mit.edu	37	17	7808456	7808456	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr17:7808456G>C	ENST00000380358.4	+	26	4289	c.4288G>C	c.(4288-4290)Gat>Cat	p.D1430H	CHD3_ENST00000358181.4_Missense_Mutation_p.D1371H|CHD3_ENST00000330494.7_Missense_Mutation_p.D1371H	NM_001005271.2	NP_001005271.2	Q12873	CHD3_HUMAN	chromodomain helicase DNA binding protein 3	1371					chromatin modification|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	microtubule organizing center|NuRD complex	ATP binding|ATP-dependent DNA helicase activity|DNA binding|protein binding|zinc ion binding			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(11)|kidney(6)|large_intestine(13)|liver(2)|lung(14)|ovary(1)|pancreas(1)|prostate(7)|skin(3)|urinary_tract(2)	65		Prostate(122;0.202)				AGAGGAGGAGGATGAAGACTT	0.537000													4	93					0	0	1	0	0
PROX2	283571	broad.mit.edu	37	14	75323591	75323591	+	Silent	SNP	G	G	A			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr14:75323591G>A	ENST00000556084.2	-	2	839	c.840C>T	c.(838-840)gtC>gtT	p.V280V	PROX2_ENST00000556489.2_Silent_p.V507V|PROX2_ENST00000445876.1_Silent_p.V507V	NM_001080408.2	NP_001073877.2	Q3B8N5	PROX2_HUMAN	prospero homeobox 2	507					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			kidney(1)|large_intestine(2)|lung(3)	6			KIRC - Kidney renal clear cell carcinoma(43;0.238)	BRCA - Breast invasive adenocarcinoma(234;0.00652)		TGGGATTTGTGACACCATCTG	0.418000													8	144					0	0	1	0	0
HAVCR2	84868	broad.mit.edu	37	5	156533909	156533909	+	Silent	SNP	G	G	A			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr5:156533909G>A	ENST00000307851.4	-	2	853	c.123C>T	c.(121-123)acC>acT	p.T41T	CTB-120L21.1_ENST00000517708.1_RNA|HAVCR2_ENST00000522593.1_Silent_p.T41T|HAVCR2_ENST00000517358.1_5'UTR	NM_032782.4	NP_116171.3	Q8TDQ0	HAVR2_HUMAN	hepatitis A virus cellular receptor 2	41	Ig-like V-type.					integral to membrane				cervix(1)|large_intestine(4)|lung(12)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	22	Renal(175;0.00212)	Medulloblastoma(196;0.0354)|all_neural(177;0.0999)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			GGGCGGCTGGGGTGTAGAAGC	0.577000													5	130					0	0	1	0	0
DCLK1	9201	broad.mit.edu	37	13	36384994	36384994	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr13:36384994G>C	ENST00000255448.4	-	12	1877	c.1666C>G	c.(1666-1668)Cca>Gca	p.P556A	DCLK1_ENST00000379893.1_Missense_Mutation_p.P249A|DCLK1_ENST00000360631.3_Missense_Mutation_p.P556A	NM_004734.4	NP_004725.1	O15075	DCLK1_HUMAN	doublecortin-like kinase 1	556	Protein kinase.				cell differentiation|central nervous system development|endosome transport|intracellular signal transduction|response to virus	integral to plasma membrane	ATP binding|protein serine/threonine kinase activity|receptor signaling protein activity			breast(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(18)|lung(17)|ovary(2)|prostate(3)|skin(4)|stomach(6)|urinary_tract(1)	64		Breast(139;0.0147)|Lung SC(185;0.0685)|Prostate(109;0.122)	KIRC - Kidney renal clear cell carcinoma(5;0.119)|Kidney(79;0.169)	all cancers(112;1.72e-06)|Epithelial(112;4.24e-05)|BRCA - Breast invasive adenocarcinoma(63;0.00159)|OV - Ovarian serous cystadenocarcinoma(117;0.0158)|GBM - Glioblastoma multiforme(144;0.0638)		ATGATTTCTGGAGCCACGTAT	0.483000													15	223					0	0	1	0	0
OR4C6	219432	broad.mit.edu	37	11	55433207	55433207	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr11:55433207G>A	ENST00000314259.3	+	1	594	c.565G>A	c.(565-567)Gac>Aac	p.D189N		NM_001004704.1	NP_001004704.1	Q8NH72	OR4C6_HUMAN	olfactory receptor, family 4, subfamily C, member 6	189					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(4)|lung(49)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	71						TGCCTGCACGGACACCCACAT	0.433000													31	182					0	0	1	0	0
DMXL2	23312	broad.mit.edu	37	15	51791702	51791702	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr15:51791702G>C	ENST00000251076.5	-	18	4006	c.3719C>G	c.(3718-3720)tCt>tGt	p.S1240C	DMXL2_ENST00000543779.2_Missense_Mutation_p.S1240C|DMXL2_ENST00000449909.3_Intron	NM_001174116.1|NM_015263.3	NP_001167587.1|NP_056078.2	Q8TDJ6	DMXL2_HUMAN	Dmx-like 2	1240						cell junction|synaptic vesicle membrane	Rab GTPase binding			breast(4)|central_nervous_system(1)|cervix(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(26)|liver(1)|lung(28)|ovary(7)|prostate(7)|skin(4)|stomach(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	101				all cancers(107;0.00494)		ATCAACAGAAGATACCAAGTC	0.418000													9	134					0	0	1	0	0
EXOC2	55770	broad.mit.edu	37	6	549252	549252	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr6:549252G>C	ENST00000230449.4	-	22	2296	c.2161C>G	c.(2161-2163)Cta>Gta	p.L721V	EXOC2_ENST00000448181.3_Missense_Mutation_p.L316V	NM_018303.4	NP_060773.3	Q96KP1	EXOC2_HUMAN	exocyst complex component 2	721					exocytosis|protein transport					breast(4)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(9)|liver(1)|lung(16)|ovary(4)|pancreas(1)|prostate(2)	46	Ovarian(93;0.0733)	Breast(5;0.0014)|all_lung(73;0.0697)|all_hematologic(90;0.0897)		OV - Ovarian serous cystadenocarcinoma(45;0.0507)|BRCA - Breast invasive adenocarcinoma(62;0.14)		TGACGTTCTAGATAGCAGCAA	0.378000													13	155					0	0	1	0	0
C22orf43	51233	broad.mit.edu	37	22	23974145	23974145	+	Silent	SNP	G	G	A			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr22:23974145G>A	ENST00000317749.5	-	1	363	c.66C>T	c.(64-66)ccC>ccT	p.P22P	AP000346.2_ENST00000390329.2_RNA	NM_016449.3	NP_057533.2	Q6PGQ1	CV043_HUMAN	chromosome 22 open reading frame 43	22										endometrium(1)|large_intestine(3)|lung(5)|pancreas(1)|skin(1)	11						ATTCATAACAGGGTGCGTCCT	0.547000													5	120					0	0	1	0	0
EIF2AK3	9451	broad.mit.edu	37	2	88913261	88913261	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr2:88913261G>A	ENST00000303236.3	-	2	720	c.419C>T	c.(418-420)tCc>tTc	p.S140F	EIF2AK3_ENST00000419748.1_5'UTR	NM_004836.5	NP_004827.4	Q9NZJ5	E2AK3_HUMAN	eukaryotic translation initiation factor 2-alpha kinase 3	140					activation of caspase activity|bone mineralization|calcium-mediated signaling|chondrocyte development|endocrine pancreas development|endoplasmic reticulum organization|endoplasmic reticulum unfolded protein response|ER overload response|insulin secretion|insulin-like growth factor receptor signaling pathway|negative regulation of myelination|negative regulation of translational initiation in response to stress|protein autophosphorylation|protein homooligomerization	endoplasmic reticulum membrane|integral to membrane	ATP binding|eukaryotic translation initiation factor 2alpha kinase activity|identical protein binding			ovary(3)	3						GCTAAGGCTGGATGACACCAA	0.398000													5	125					0	0	1	0	0
CYP27B1	1594	broad.mit.edu	37	12	58160810	58160810	+	Silent	SNP	G	G	C			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr12:58160810G>C	ENST00000228606.4	-	1	224	c.15C>G	c.(13-15)ctC>ctG	p.L5L	RP11-571M6.13_ENST00000546609.1_RNA	NM_000785.3	NP_000776.1	O15528	CP27B_HUMAN	cytochrome P450, family 27, subfamily B, polypeptide 1	5					bone mineralization|calcium ion homeostasis|calcium ion transport|decidualization|G1 to G0 transition|hormone biosynthetic process|negative regulation of calcidiol 1-monooxygenase activity|negative regulation of cell growth|negative regulation of cell proliferation|positive regulation of keratinocyte differentiation|positive regulation of vitamin D 24-hydroxylase activity|positive regulation of vitamin D receptor signaling pathway|regulation of bone mineralization|response to estrogen stimulus|response to interferon-gamma|response to lipopolysaccharide|response to tumor necrosis factor|response to vitamin D|vitamin D biosynthetic process|xenobiotic metabolic process	mitochondrial outer membrane	calcidiol 1-monooxygenase activity|electron carrier activity|heme binding			central_nervous_system(3)|endometrium(1)|kidney(1)|large_intestine(3)|lung(5)|prostate(1)|urinary_tract(1)	15	all_cancers(7;8.09e-80)|Lung NSC(6;2.26e-27)|all_lung(6;1.99e-25)|all_epithelial(6;3.62e-18)|Glioma(12;6.95e-05)|all_neural(12;0.00016)|Melanoma(17;0.122)		GBM - Glioblastoma multiforme(5;1.97e-113)|all cancers(5;1.54e-78)|BRCA - Breast invasive adenocarcinoma(9;0.0294)		Calcidiol(DB00146)|Calcitriol(DB00136)|Ergocalciferol(DB00153)	AGGCGTACTTGAGGGTCTGGG	0.587000													7	163					0	0	1	0	0
RIF1	55183	broad.mit.edu	37	2	152301876	152301876	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr2:152301876G>A	ENST00000243326.4	+	18	2494	c.2011G>A	c.(2011-2013)Gcc>Acc	p.A671T	RIF1_ENST00000444746.2_Missense_Mutation_p.A671T|RIF1_ENST00000430328.2_Missense_Mutation_p.A671T|RIF1_ENST00000428287.2_Missense_Mutation_p.A671T|RIF1_ENST00000453091.2_Missense_Mutation_p.A671T			Q5UIP0	RIF1_HUMAN	RAP1 interacting factor homolog (yeast)	671					cell cycle|response to DNA damage stimulus	chromosome, telomeric region|cytoplasm|nucleus|spindle	binding			NS(2)|breast(8)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(19)|liver(1)|lung(34)|ovary(6)|pancreas(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	97				BRCA - Breast invasive adenocarcinoma(221;0.0429)		TCAAGGTGATGCCTTAGAACA	0.313000													6	63					0	0	1	0	0
ZNF528	84436	broad.mit.edu	37	19	52918855	52918855	+	Silent	SNP	C	C	T			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr19:52918855C>T	ENST00000360465.3	+	7	1176	c.750C>T	c.(748-750)ttC>ttT	p.F250F	ZNF528_ENST00000391788.2_3'UTR	NM_032423.2	NP_115799.2	Q3MIS6	ZN528_HUMAN	zinc finger protein 528	250					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(6)|ovary(1)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	39				GBM - Glioblastoma multiforme(134;0.00249)|OV - Ovarian serous cystadenocarcinoma(262;0.00817)		GCAAGCTCTTCAGTAGCAATT	0.398000													6	129					0	0	1	0	0
SPATC1	375686	broad.mit.edu	37	8	145094865	145094865	+	Silent	SNP	G	G	A			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr8:145094865G>A	ENST00000377470.3	+	2	369	c.267G>A	c.(265-267)gtG>gtA	p.V89V	SPATC1_ENST00000447830.2_Silent_p.V89V	NM_198572.2	NP_940974.2	Q76KD6	SPERI_HUMAN	spermatogenesis and centriole associated 1	89										NS(1)|central_nervous_system(1)|kidney(1)|large_intestine(1)|lung(8)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	15	all_cancers(97;8.2e-11)|all_epithelial(106;1.1e-09)|Lung NSC(106;5.89e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;6.79e-41)|Epithelial(56;1.02e-39)|all cancers(56;3.67e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			TCGAAGAAGTGGGGATCATGG	0.637000													11	108					0	0	1	0	0
NXF5	55998	broad.mit.edu	37	X	101092466	101092466	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chrX:101092466C>G	ENST00000537026.1	-	15	1439	c.1080G>C	c.(1078-1080)caG>caC	p.Q360H	NXF5_ENST00000473265.2_Missense_Mutation_p.Q360H|NXF5_ENST00000361708.2_Missense_Mutation_p.Q360H	NM_032946.2	NP_116564.2	Q9H1B4	NXF5_HUMAN	nuclear RNA export factor 5	360	NTF2; truncated.				mRNA export from nucleus|multicellular organismal development	actin cytoskeleton|cytoplasm|nucleus	nucleocytoplasmic transporter activity|nucleotide binding|protein binding|RNA binding			breast(2)|central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(7)|lung(16)|skin(1)	30						CTACCCACCTCTGGCTCTCTG	0.547000													18	134					0	0	1	0	0
LRRC37BP1	147172	broad.mit.edu	37	17	28961071	28961071	+	RNA	SNP	G	G	C			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr17:28961071G>C	ENST00000417404.1	+	0	1329				LRRC37BP1_ENST00000412831.1_RNA|SMURF2P1_ENST00000578265.1_RNA																							CAATATCTGTGACTGTCATAC	0.254000													4	56					0	0	1	0	0
GALNT7	51809	broad.mit.edu	37	4	174242759	174242759	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr4:174242759C>T	ENST00000265000.4	+	12	1948	c.1865C>T	c.(1864-1866)tCa>tTa	p.S622L		NM_017423.2	NP_059119.2	Q86SF2	GALT7_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 7 (GalNAc-T7)	622	Ricin B-type lectin.				protein O-linked glycosylation	Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			central_nervous_system(1)|kidney(3)|large_intestine(5)|liver(1)|lung(9)	19		Prostate(90;0.0132)|Renal(120;0.0183)|Melanoma(52;0.0749)|all_hematologic(60;0.107)|all_neural(102;0.122)		all cancers(43;1.87e-18)|Epithelial(43;3.44e-17)|OV - Ovarian serous cystadenocarcinoma(60;2.48e-09)|STAD - Stomach adenocarcinoma(60;0.0019)|GBM - Glioblastoma multiforme(59;0.0119)|LUSC - Lung squamous cell carcinoma(193;0.0199)		CATATTCCTTCAGGAAAGTGT	0.373000													6	93					0	0	1	0	0
USP8	9101	broad.mit.edu	37	15	50790857	50790857	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr15:50790857C>G	ENST00000433963.1	+	20	3603	c.3103C>G	c.(3103-3105)Ctt>Gtt	p.L1035V	USP8_ENST00000307179.4_Missense_Mutation_p.L1035V|RP11-562A8.4_ENST00000560380.1_RNA|USP8_ENST00000396444.3_Missense_Mutation_p.L1035V|USP8_ENST00000425032.3_Missense_Mutation_p.L929V	NM_001128611.1	NP_001122083.1	P40818	UBP8_HUMAN	ubiquitin specific peptidase 8	1035					cell cycle|cell proliferation|endosome organization|protein K48-linked deubiquitination|protein K63-linked deubiquitination|ubiquitin-dependent protein catabolic process	cytosol|early endosome|extrinsic to plasma membrane|nucleus	cysteine-type endopeptidase activity|SH3 domain binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(5)|lung(16)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	35				all cancers(107;0.000225)|GBM - Glioblastoma multiforme(94;0.000771)		GTTAGAAAATCTTGACTTGTC	0.343000													4	134					0	0	1	0	0
FLG	2312	broad.mit.edu	37	1	152277637	152277637	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr1:152277637G>A	ENST00000368799.1	-	3	9760	c.9725C>T	c.(9724-9726)tCt>tTt	p.S3242F	FLG-AS1_ENST00000420707.1_RNA|FLG-AS1_ENST00000593011.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	3242	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CTCCTGAACAGATCCACGATG	0.592000									Ichthyosis				24	428					0	0	1	0	0
GPR113	165082	broad.mit.edu	37	2	26533860	26533860	+	Silent	SNP	C	C	T			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr2:26533860C>T	ENST00000333478.6	-	8	2721	c.2139G>A	c.(2137-2139)ctG>ctA	p.L713L	GPR113_ENST00000421160.2_Silent_p.L843L|GPR113_ENST00000311519.1_Silent_p.L912L|GPR113_ENST00000541401.1_Silent_p.L515L|GPR113_ENST00000459892.1_5'UTR	NM_153835.3	NP_722577.2	Q8IZF5	GP113_HUMAN	G protein-coupled receptor 113	912	GPS.				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(5)|ovary(4)|prostate(2)|skin(1)|stomach(1)|urinary_tract(1)	24	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CCCCCTCCCTCAGGTATTGCC	0.612000													3	28					0	0	1	0	0
BMPR2	659	broad.mit.edu	37	2	203383743	203383743	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr2:203383743G>C	ENST00000374580.4	+	6	1359	c.820G>C	c.(820-822)Gaa>Caa	p.E274Q	BMPR2_ENST00000374574.2_Missense_Mutation_p.E274Q	NM_001204.6	NP_001195.2	Q13873	BMPR2_HUMAN	bone morphogenetic protein receptor, type II (serine/threonine kinase)	274	Protein kinase.				anterior/posterior pattern formation|BMP signaling pathway|cellular response to starvation|lung alveolus development|mesoderm formation|negative regulation of cell growth|negative regulation of systemic arterial blood pressure|negative regulation of vasoconstriction|positive regulation of BMP signaling pathway|positive regulation of bone mineralization|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of epithelial cell migration|positive regulation of osteoblast differentiation|positive regulation of pathway-restricted SMAD protein phosphorylation|regulation of lung blood pressure|transcription from RNA polymerase II promoter|vascular endothelial growth factor receptor signaling pathway	integral to plasma membrane	ATP binding|metal ion binding|transforming growth factor beta receptor activity			autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(6)|large_intestine(11)|lung(7)|ovary(4)|pancreas(1)|skin(1)|stomach(1)|urinary_tract(2)	42						TGGACGCATGGAATATTTGCT	0.418000													9	141					0	0	1	0	0
IGSF22	283284	broad.mit.edu	37	11	18731033	18731033	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr11:18731033C>G	ENST00000513874.1	-	18	3038	c.2899G>C	c.(2899-2901)Gag>Cag	p.E967Q	RP11-1081L13.4_ENST00000527285.1_RNA	NM_173588.3	NP_775859.3	Q8N9C0	IGS22_HUMAN	immunoglobulin superfamily, member 22	866										NS(2)|autonomic_ganglia(1)|breast(3)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(20)|ovary(4)|prostate(4)|skin(3)	56						TTCTGCCTCTCGATGAGTCCT	0.567000													5	95					0	0	1	0	0
DDTL	100037417	broad.mit.edu	37	22	24313562	24313562	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr22:24313562G>C	ENST00000215770.5	+	3	386	c.372G>C	c.(370-372)ttG>ttC	p.L124F	DDT_ENST00000398344.4_3'UTR|DDT_ENST00000350608.3_3'UTR	NM_001084393.1	NP_001077862.1	A6NHG4	DDTL_HUMAN	D-dopachrome tautomerase-like	124						cytoplasm	lyase activity			kidney(1)|urinary_tract(1)	2						AGTCATGTTTGAATGAGGAAG	0.473000													4	60					0	0	1	0	0
CCT7	10574	broad.mit.edu	37	2	73476281	73476281	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr2:73476281G>A	ENST00000539919.1	+	9	1185	c.814G>A	c.(814-816)Gag>Aag	p.E272K	CCT7_ENST00000398422.2_Missense_Mutation_p.E112K|CCT7_ENST00000258091.5_Missense_Mutation_p.E316K|CCT7_ENST00000473786.1_3'UTR|CCT7_ENST00000540468.1_Missense_Mutation_p.E229K|CCT7_ENST00000538797.1_Missense_Mutation_p.E188K|CCT7_ENST00000537131.1_Missense_Mutation_p.E216K	NM_001166285.1	NP_001159757.1	Q99832	TCPH_HUMAN	chaperonin containing TCP1, subunit 7 (eta)	316					'de novo' posttranslational protein folding		ATP binding|unfolded protein binding			breast(1)|cervix(1)|endometrium(1)|lung(3)|stomach(1)	7						CCGAGTACCTGAGGAGGATCT	0.517000													4	65					0	0	1	0	0
ZNF479	90827	broad.mit.edu	37	7	57194303	57194303	+	Silent	SNP	G	G	T			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr7:57194303G>T	ENST00000331162.4	-	3	432	c.162C>A	c.(160-162)tcC>tcA	p.S54S		NM_033273.1	NP_150376.1	Q96JC4	ZN479_HUMAN	zinc finger protein 479	54	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(14)|lung(53)|ovary(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	84			GBM - Glioblastoma multiforme(1;9.18e-12)			CCTCACCCAGGGAGACCAGGT	0.363000													5	211					0.00116845	0.00118379	1	1	0
SPTAN1	6709	broad.mit.edu	37	9	131348158	131348158	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr9:131348158G>A	ENST00000372739.3	+	19	2802	c.2692G>A	c.(2692-2694)Gat>Aat	p.D898N	SPTAN1_ENST00000372731.4_Missense_Mutation_p.D898N|SPTAN1_ENST00000358161.5_Missense_Mutation_p.D898N	NM_001130438.2	NP_001123910.1	Q13813	SPTA2_HUMAN	spectrin, alpha, non-erythrocytic 1	898					actin filament capping|axon guidance|cellular component disassembly involved in apoptosis	cytosol|intracellular membrane-bounded organelle|membrane fraction|microtubule cytoskeleton|spectrin	actin binding|calcium ion binding|calmodulin binding|structural constituent of cytoskeleton			NS(2)|breast(8)|cervix(2)|endometrium(6)|kidney(4)|large_intestine(21)|liver(1)|lung(25)|ovary(5)|pancreas(1)|prostate(4)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	87						GTACTTTGCTGATGCTAACGA	0.572000													11	82					0	0	1	0	0
RPS6KA2	6196	broad.mit.edu	37	6	166889325	166889325	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr6:166889325C>G	ENST00000366863.2	-	11	1127	c.448G>C	c.(448-450)Gag>Cag	p.E150Q	RPS6KA2_ENST00000405189.3_Intron|RPS6KA2_ENST00000265678.4_Intron|RPS6KA2_ENST00000510118.1_Intron|RPS6KA2_ENST00000503859.1_Intron|RPS6KA2_ENST00000481261.2_Intron			Q15349	KS6A2_HUMAN	ribosomal protein S6 kinase, 90kDa, polypeptide 2	0	Protein kinase 1.				axon guidance|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|stress-activated MAPK cascade|synaptic transmission|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(13)|lung(15)|ovary(2)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	45		Breast(66;2.04e-05)|Ovarian(120;0.0652)|Prostate(117;0.105)		OV - Ovarian serous cystadenocarcinoma(33;2.76e-18)|GBM - Glioblastoma multiforme(31;9.94e-06)|BRCA - Breast invasive adenocarcinoma(81;1.36e-05)		GCCGTTTTCTCACCTGCAGAG	0.483000													5	76					0	0	1	0	0
TMPRSS11A	339967	broad.mit.edu	37	4	68812202	68812202	+	Silent	SNP	C	C	A	rs147036994		TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr4:68812202C>A	ENST00000508048.1	-	2	131	c.96G>T	c.(94-96)gtG>gtT	p.V32V	TMPRSS11A_ENST00000334830.7_Silent_p.V33V|TMPRSS11A_ENST00000396188.2_Silent_p.V33V|RP11-453E17.1_ENST00000500538.2_RNA			Q6ZMR5	TM11A_HUMAN	transmembrane protease, serine 11A	33					cell cycle|proteolysis	extracellular region|integral to plasma membrane	serine-type endopeptidase activity			breast(1)|cervix(2)|kidney(1)|large_intestine(8)|lung(11)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)	29						GACCTATGGTCACTGCCACCA	0.408000													7	79					5.4927e-09	5.6282e-09	1	1	0
NPTX1	4884	broad.mit.edu	37	17	78447056	78447056	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr17:78447056C>G	ENST00000306773.4	-	3	998	c.841G>C	c.(841-843)Gag>Cag	p.E281Q		NM_002522.3	NP_002513.2	Q15818	NPTX1_HUMAN	neuronal pentraxin I	281	Pentaxin.				central nervous system development|synaptic transmission|transport	transport vesicle	metal ion binding			kidney(1)|large_intestine(2)|liver(1)|lung(4)|prostate(2)|upper_aerodigestive_tract(1)	11	all_neural(118;0.0538)		BRCA - Breast invasive adenocarcinoma(99;0.0232)|OV - Ovarian serous cystadenocarcinoma(97;0.0487)			AGGACCAGCTCGTTGGCCTGG	0.642000													8	115					0	0	1	0	0
FANCI	55215	broad.mit.edu	37	15	89843085	89843085	+	Silent	SNP	G	G	A			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr15:89843085G>A	ENST00000310775.7	+	25	2777	c.2691G>A	c.(2689-2691)aaG>aaA	p.K897K	FANCI_ENST00000300027.8_Silent_p.K837K	NM_001113378.1	NP_001106849.1	Q9NVI1	FANCI_HUMAN	Fanconi anemia, complementation group I	897					cell cycle|DNA repair	nucleoplasm	protein binding			breast(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(7)|ovary(2)|pancreas(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	31	Lung NSC(78;0.0472)|all_lung(78;0.089)					AGTCGGGAAAGAAAGAGAAAG	0.428000								Involved in tolerance or repair of DNA crosslinks	Fanconi Anemia				9	79					0	0	1	0	0
DLGAP2	9228	broad.mit.edu	37	8	1649519	1649519	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr8:1649519G>A	ENST00000421627.2	+	12	3009	c.2875G>A	c.(2875-2877)Gag>Aag	p.E959K		NM_004745.3	NP_004736.2	Q9P1A6	DLGP2_HUMAN	discs, large (Drosophila) homolog-associated protein 2	1038					neuron-neuron synaptic transmission	cell junction|neurofilament|postsynaptic density|postsynaptic membrane	protein binding			breast(1)|endometrium(6)|lung(31)|prostate(3)	41		Ovarian(12;0.0271)|Hepatocellular(245;0.0838)|Colorectal(14;0.0846)		BRCA - Breast invasive adenocarcinoma(11;0.000169)|READ - Rectum adenocarcinoma(644;0.171)		TTCCGCCTCCGAGCGCGCGGA	0.687000													3	13					0	0	1	0	0
ZNF236	7776	broad.mit.edu	37	18	74631794	74631794	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr18:74631794G>A	ENST00000253159.8	+	20	3529	c.3331G>A	c.(3331-3333)Gag>Aag	p.E1111K	ZNF236_ENST00000320610.9_Missense_Mutation_p.E1113K	NM_007345.3	NP_031371.3	Q9UL36	ZN236_HUMAN	zinc finger protein 236	1111					cellular response to glucose stimulus	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(43)|ovary(7)|pancreas(1)|prostate(6)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	94		Prostate(75;0.0405)|Esophageal squamous(42;0.129)|Melanoma(33;0.132)		OV - Ovarian serous cystadenocarcinoma(15;4.36e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0686)		GTCTCGTCCTGAGGTCATCAC	0.517000													11	163					0	0	1	0	0
ATAD5	79915	broad.mit.edu	37	17	29220954	29220954	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr17:29220954G>C	ENST00000321990.4	+	21	5461	c.5083G>C	c.(5083-5085)Gag>Cag	p.E1695Q		NM_024857.3	NP_079133.3	Q96QE3	ATAD5_HUMAN	ATPase family, AAA domain containing 5	1695					response to DNA damage stimulus	nucleus	ATP binding|nucleoside-triphosphatase activity			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(8)|kidney(3)|large_intestine(18)|lung(13)|ovary(3)|pancreas(1)	51		all_hematologic(16;0.0202)|Acute lymphoblastic leukemia(14;0.0238)|Myeloproliferative disorder(56;0.0393)				GTTTAGTCTTGAGAGTAATGA	0.368000													5	111					0	0	1	0	0
TCFL5	10732	broad.mit.edu	37	20	61492825	61492825	+	Silent	SNP	C	C	T			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr20:61492825C>T	ENST00000335351.3	-	1	290	c.198G>A	c.(196-198)gaG>gaA	p.E66E	TCFL5_ENST00000217162.5_Silent_p.E18E	NM_006602.2	NP_006593.2	Q9UL49	TCFL5_HUMAN	transcription factor-like 5 (basic helix-loop-helix)	66					cell differentiation|multicellular organismal development|regulation of cell differentiation|regulation of cell proliferation|spermatogenesis|transcription from RNA polymerase II promoter		DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(1)|large_intestine(5)|lung(1)|urinary_tract(1)	9	Breast(26;5.68e-08)					CAGCCGCCGCCTCCATGTGCG	0.736000													4	26					0	0	1	0	0
GBE1	2632	broad.mit.edu	37	3	81695605	81695605	+	Silent	SNP	G	G	A			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr3:81695605G>A	ENST00000429644.2	-	6	1363	c.720C>T	c.(718-720)atC>atT	p.I240I	GBE1_ENST00000489715.1_Silent_p.I199I	NM_000158.3	NP_000149.3	Q04446	GLGB_HUMAN	glucan (1,4-alpha-), branching enzyme 1	240					glucose metabolic process|glycogen biosynthetic process	cytosol	1,4-alpha-glucan branching enzyme activity|cation binding|hydrolase activity, hydrolyzing O-glycosyl compounds			breast(1)|endometrium(5)|large_intestine(2)|lung(4)|ovary(3)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	18		Lung NSC(201;0.0117)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0654)|Epithelial(33;0.00305)|LUSC - Lung squamous cell carcinoma(29;0.00646)|BRCA - Breast invasive adenocarcinoma(55;0.00813)|Lung(72;0.0129)|KIRC - Kidney renal clear cell carcinoma(39;0.212)|Kidney(39;0.247)		CATGCTCCATGATTGCCATCA	0.348000									Glycogen Storage Disease, type IV				11	120					0	0	1	0	0
TRPC4AP	26133	broad.mit.edu	37	20	33632354	33632354	+	Silent	SNP	C	C	T			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr20:33632354C>T	ENST00000252015.2	-	7	908	c.819G>A	c.(817-819)caG>caA	p.Q273Q	TRPC4AP_ENST00000451813.1_Silent_p.Q273Q|TRPC4AP_ENST00000432634.2_Silent_p.Q234Q			Q8TEL6	TP4AP_HUMAN	transient receptor potential cation channel, subfamily C, member 4 associated protein	273	Interaction with TNFRSF1A (By similarity).				protein ubiquitination|ubiquitin-dependent protein catabolic process	Cul4A-RING ubiquitin ligase complex	protein binding			breast(3)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(13)|skin(1)|stomach(1)|urinary_tract(1)	32			BRCA - Breast invasive adenocarcinoma(18;0.00936)			AGCTCTTCTTCTGTTGAGCAT	0.448000													14	130					0	0	1	0	0
RAB11FIP1	80223	broad.mit.edu	37	8	37732103	37732103	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr8:37732103C>G	ENST00000330843.4	-	3	1564	c.1552G>C	c.(1552-1554)Gag>Cag	p.E518Q	RAB11FIP1_ENST00000522727.1_Missense_Mutation_p.E370Q|RAB11FIP1_ENST00000524118.1_Missense_Mutation_p.E370Q|RAB11FIP1_ENST00000287263.4_Missense_Mutation_p.E518Q	NM_001002814.2	NP_001002814.2	Q6WKZ4	RFIP1_HUMAN	RAB11 family interacting protein 1 (class I)	518					protein transport	centrosome|phagocytic vesicle membrane|recycling endosome	protein binding			NS(1)|breast(1)|central_nervous_system(4)|endometrium(3)|large_intestine(6)|lung(20)|ovary(3)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	49		Lung NSC(58;0.118)|all_lung(54;0.195)	LUSC - Lung squamous cell carcinoma(8;3.62e-11)			GACTTGGACTCTGGCTCAGCT	0.542000													6	88					0	0	1	0	0
HMCN1	83872	broad.mit.edu	37	1	185984368	185984368	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr1:185984368G>A	ENST00000271588.4	+	31	4937	c.4708G>A	c.(4708-4710)Gaa>Aaa	p.E1570K	HMCN1_ENST00000367492.2_Missense_Mutation_p.E1570K	NM_031935.2	NP_114141.2	Q96RW7	HMCN1_HUMAN	hemicentin 1	1570	Ig-like C2-type 13.			E -> K (in Ref. 1).	response to stimulus|visual perception	basement membrane	calcium ion binding			NS(2)|autonomic_ganglia(1)|breast(10)|central_nervous_system(2)|cervix(1)|endometrium(28)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(58)|liver(3)|lung(101)|ovary(23)|pancreas(4)|prostate(20)|skin(8)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(18)	308						ACTGGAATGTGAAACACGGGG	0.398000													5	85					0	0	1	0	0
ARID1A	8289	broad.mit.edu	37	1	27057874	27057874	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr1:27057874C>T	ENST00000324856.7	+	3	1953	c.1582C>T	c.(1582-1584)Cag>Tag	p.Q528*	ARID1A_ENST00000457599.2_Nonsense_Mutation_p.Q528*|ARID1A_ENST00000374152.2_Nonsense_Mutation_p.Q145*	NM_006015.4	NP_006006.3	O14497	ARI1A_HUMAN	AT rich interactive domain 1A (SWI-like)	528					androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding		ARID1A/MAST2_ENST00000361297(2)	NS(1)|autonomic_ganglia(1)|biliary_tract(1)|breast(13)|central_nervous_system(6)|cervix(2)|endometrium(56)|haematopoietic_and_lymphoid_tissue(8)|kidney(10)|large_intestine(41)|liver(31)|lung(34)|ovary(130)|pancreas(18)|prostate(8)|skin(9)|stomach(14)|upper_aerodigestive_tract(4)|urinary_tract(24)	411		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		GCCTCCACATCAGCAGTCCCC	0.617000			"""Mis, N, F, S, D"""		"""clear cell ovarian carcinoma, RCC"""								15	258					0	0	1	0	0
CDC42BPG	55561	broad.mit.edu	37	11	64602837	64602837	+	Silent	SNP	C	C	T			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr11:64602837C>T	ENST00000342711.5	-	16	1934	c.1935G>A	c.(1933-1935)ctG>ctA	p.L645L		NM_017525.2	NP_059995.2	Q6DT37	MRCKG_HUMAN	CDC42 binding protein kinase gamma (DMPK-like)	645					actin cytoskeleton reorganization|intracellular signal transduction	cell leading edge|centrosome	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			central_nervous_system(1)|lung(3)	4						GCTCCCGGCTCAGCCTCCGGT	0.657000													24	380					0	0	1	0	0
FAM57A	79850	broad.mit.edu	37	17	644738	644738	+	Silent	SNP	C	C	T			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr17:644738C>T	ENST00000308278.8	+	5	938	c.702C>T	c.(700-702)atC>atT	p.I234I	FAM57A_ENST00000301324.8_Silent_p.I202I	NM_024792.1	NP_079068.1	Q8TBR7	FA57A_HUMAN	family with sequence similarity 57, member A	234	TLC.					integral to membrane|plasma membrane				cervix(1)|endometrium(2)|large_intestine(1)|lung(2)|prostate(2)|urinary_tract(2)	10				UCEC - Uterine corpus endometrioid carcinoma (25;0.0217)		CTCCTCAGATCTACTGGTTCT	0.567000													6	85					0	0	1	0	0
GPR123	84435	broad.mit.edu	37	10	134896174	134896174	+	Silent	SNP	G	G	A			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr10:134896174G>A	ENST00000607359.1	+	6	1260	c.1260G>A	c.(1258-1260)ctG>ctA	p.L420L				Q86SQ6	GP123_HUMAN	G protein-coupled receptor 123	0						integral to membrane|plasma membrane	G-protein coupled receptor activity			endometrium(2)|kidney(2)|large_intestine(1)|lung(6)|prostate(3)	14		all_cancers(35;1.8e-10)|all_epithelial(44;8.95e-09)|Lung NSC(174;0.000845)|all_lung(145;0.00144)|all_neural(114;0.0299)|Colorectal(31;0.0585)|Melanoma(40;0.123)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;9.16e-06)|Epithelial(32;1.21e-05)|all cancers(32;1.63e-05)		GCCTTGGCCTGAGGTGGGCAT	0.622000													4	27					0	0	1	0	0
RPL32P3	132241	broad.mit.edu	37	3	129116038	129116038	+	RNA	SNP	C	C	T			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr3:129116038C>T	ENST00000514355.1	-	0	412																				lung(1)	1						GAGGCTTTCCCGCCCAGGGAC	0.567000													6	166					0	0	1	0	0
HMGCL	3155	broad.mit.edu	37	1	24129001	24129001	+	Silent	SNP	C	C	T			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr1:24129001C>T	ENST00000374483.4	-	10	1526	c.855G>A	c.(853-855)ctG>ctA	p.L285L	HMGCL_ENST00000374490.3_Silent_p.L310L|HMGCL_ENST00000436439.2_Silent_p.L239L			P35914	HMGCL_HUMAN	3-hydroxymethyl-3-methylglutaryl-CoA lyase	310					acetoacetic acid biosynthetic process|ketone body biosynthetic process	mitochondrial matrix	hydroxymethylglutaryl-CoA lyase activity|metal ion binding			central_nervous_system(1)|endometrium(2)|large_intestine(2)|lung(3)|ovary(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	12		Colorectal(325;3.46e-05)|Renal(390;0.000219)|Lung NSC(340;0.000233)|all_lung(284;0.000321)|Ovarian(437;0.00348)|Breast(348;0.0044)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;2.38e-24)|Colorectal(126;5.58e-08)|COAD - Colon adenocarcinoma(152;3.12e-06)|GBM - Glioblastoma multiforme(114;4.9e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000982)|KIRC - Kidney renal clear cell carcinoma(1967;0.0034)|STAD - Stomach adenocarcinoma(196;0.0128)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.0856)|LUSC - Lung squamous cell carcinoma(448;0.188)		TTTTTCTGTTCAGGGCTTGAC	0.498000													7	124					0	0	1	0	0
GLDC	2731	broad.mit.edu	37	9	6606647	6606647	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr9:6606647G>C	ENST00000321612.6	-	5	808	c.658C>G	c.(658-660)Ctc>Gtc	p.L220V		NM_000170.2	NP_000161.2	P23378	GCSP_HUMAN	glycine dehydrogenase (decarboxylating)	220					glycine catabolic process	mitochondrion	electron carrier activity|glycine dehydrogenase (decarboxylating) activity|lyase activity|pyridoxal phosphate binding			cervix(1)|endometrium(2)|large_intestine(5)|lung(23)|ovary(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	37		Acute lymphoblastic leukemia(23;0.161)		GBM - Glioblastoma multiforme(50;0.0421)|Lung(218;0.134)	Glycine(DB00145)|Pyridoxal Phosphate(DB00114)	GGATCAACGAGAAATTTCCTC	0.373000													5	152					0	0	1	0	0
DIXDC1	85458	broad.mit.edu	37	11	111887438	111887438	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr11:111887438C>G	ENST00000440460.2	+	19	2074	c.1777C>G	c.(1777-1779)Cca>Gca	p.P593A	DIXDC1_ENST00000389821.4_3'UTR|DIXDC1_ENST00000315253.5_Missense_Mutation_p.P382A	NM_001037954.2	NP_001033043.1	Q155Q3	DIXC1_HUMAN	DIX domain containing 1	594					multicellular organismal development|positive regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	cytosol|focal adhesion	actin binding|gamma-tubulin binding|signal transducer activity			cervix(2)|endometrium(4)|kidney(1)|large_intestine(3)|lung(6)|ovary(1)	17		all_cancers(61;7.58e-15)|all_epithelial(67;5.42e-09)|Melanoma(852;1.91e-06)|all_hematologic(158;0.000405)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0112)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		Epithelial(105;2.99e-07)|BRCA - Breast invasive adenocarcinoma(274;6.72e-07)|all cancers(92;6.25e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.0548)		ACAGAGCTCTCCAACTGTCAG	0.453000													3	27					0	0	1	0	0
GPM6B	2824	broad.mit.edu	37	X	13794420	13794420	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chrX:13794420G>C	ENST00000454189.2	-	6	724	c.597C>G	c.(595-597)ttC>ttG	p.F199L	GPM6B_ENST00000356942.5_Missense_Mutation_p.F218L|GPM6B_ENST00000493677.1_Missense_Mutation_p.F232L|GPM6B_ENST00000398361.3_Missense_Mutation_p.F132L|GPM6B_ENST00000316715.4_Missense_Mutation_p.F258L|GPM6B_ENST00000355135.2_Missense_Mutation_p.F258L	NM_001001994.1	NP_001001994.1	Q13491	GPM6B_HUMAN	glycoprotein M6B	218					cell differentiation|nervous system development	integral to membrane				central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|ovary(1)|pancreas(1)	6						AGGACATGTAGAACTACAAAA	0.493000													6	61					0	0	1	0	0
LBH	81606	broad.mit.edu	37	2	30457343	30457343	+	Silent	SNP	C	C	T			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr2:30457343C>T	ENST00000395323.3	+	2	307	c.99C>T	c.(97-99)ctC>ctT	p.L33L	LBH_ENST00000467242.1_3'UTR|LBH_ENST00000401506.1_Silent_p.L39L|LBH_ENST00000404397.1_Silent_p.L33L|LBH_ENST00000407930.2_Silent_p.L16L|LBH_ENST00000406087.1_Silent_p.L33L	NM_030915.3	NP_112177.2	Q53QV2	LBH_HUMAN	limb bud and heart development	33					multicellular organismal development|transcription, DNA-dependent	cytoplasm|nucleolus				endometrium(2)|large_intestine(1)|lung(2)	5	Acute lymphoblastic leukemia(172;0.155)					AGATCGGCCTCAGCCCCCGCA	0.557000													6	76					0	0	1	0	0
ADAMTS19	171019	broad.mit.edu	37	5	129070703	129070703	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr5:129070703G>A	ENST00000274487.4	+	22	3518	c.3373G>A	c.(3373-3375)Gaa>Aaa	p.E1125K	CTC-575N7.1_ENST00000503616.1_RNA|ADAMTS19_ENST00000509467.1_3'UTR	NM_133638.3	NP_598377.3	Q8TE59	ATS19_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 19	1125	TSP type-1 5.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(4)|endometrium(10)|kidney(9)|large_intestine(14)|lung(34)|ovary(6)|pancreas(1)|prostate(6)|skin(6)	91		all_cancers(142;0.0148)|Prostate(80;0.0494)|Breast(839;0.238)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	OV - Ovarian serous cystadenocarcinoma(64;0.222)		ACATGGAAATGAATGTTTTTC	0.418000													6	97					0	0	1	0	0
TMEM108	66000	broad.mit.edu	37	3	133099627	133099627	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr3:133099627G>A	ENST00000515826.1	+	3	1195	c.1072G>A	c.(1072-1074)Ggg>Agg	p.G358R	TMEM108_ENST00000393130.3_Missense_Mutation_p.G358R|TMEM108_ENST00000508711.1_Intron|TMEM108_ENST00000321871.6_Missense_Mutation_p.G358R			Q6UXF1	TM108_HUMAN	transmembrane protein 108	358						integral to membrane				endometrium(3)|kidney(1)|large_intestine(5)|lung(22)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	38						GGCTGCCACGGGGCCCACCCC	0.622000													5	84					0	0	1	0	0
DAGLA	747	broad.mit.edu	37	11	61502369	61502369	+	Silent	SNP	C	C	T			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr11:61502369C>T	ENST00000257215.5	+	10	1139	c.1023C>T	c.(1021-1023)atC>atT	p.I341I		NM_006133.2	NP_006124.1	Q9Y4D2	DGLA_HUMAN	diacylglycerol lipase, alpha	341					cell death|lipid catabolic process|platelet activation	integral to membrane|plasma membrane	acylglycerol lipase activity|metal ion binding|triglyceride lipase activity			breast(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|liver(2)|lung(17)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(4)	43				READ - Rectum adenocarcinoma(4;0.219)		GAGTCACCATCGAGGAAGACA	0.602000													27	230					0	0	1	0	0
PGK2	5232	broad.mit.edu	37	6	49754123	49754123	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr6:49754123C>T	ENST00000304801.3	-	1	930	c.778G>A	c.(778-780)Gaa>Aaa	p.E260K		NM_138733.4	NP_620061.2	P07205	PGK2_HUMAN	phosphoglycerate kinase 2	260					glycolysis	cytosol	ATP binding|phosphoglycerate kinase activity			autonomic_ganglia(1)|endometrium(3)|large_intestine(12)|lung(25)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	47	Lung NSC(77;0.0402)					GCTCCCTCTTCATCAAACAGG	0.403000													5	211					0	0	1	0	0
TLR3	7098	broad.mit.edu	37	4	187004931	187004931	+	Silent	SNP	A	A	G			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr4:187004931A>G	ENST00000296795.2	+	4	2195	c.2091A>G	c.(2089-2091)aaA>aaG	p.K697K	TLR3_ENST00000504367.1_Silent_p.K420K	NM_003265.2	NP_003256.1	O15455	TLR3_HUMAN	toll-like receptor 3	697	LRRCT.				activation of NF-kappaB-inducing kinase activity|cellular response to mechanical stimulus|defense response to bacterium|defense response to virus|detection of virus|hyperosmotic response|I-kappaB phosphorylation|inflammatory response|innate immune response|MyD88-independent toll-like receptor signaling pathway|negative regulation of osteoclast differentiation|positive regulation of chemokine production|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of interferon-beta production|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of toll-like receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|toll-like receptor 3 signaling pathway	endoplasmic reticulum membrane|endosome membrane|integral to plasma membrane	double-stranded RNA binding|transmembrane receptor activity			breast(1)|endometrium(5)|large_intestine(8)|lung(8)|ovary(2)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	29		all_cancers(14;4.27e-52)|all_epithelial(14;7.69e-39)|all_lung(41;1.34e-13)|Lung NSC(41;3.58e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.0066)|Hepatocellular(41;0.00886)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|all_neural(102;0.243)		OV - Ovarian serous cystadenocarcinoma(60;1.47e-11)|BRCA - Breast invasive adenocarcinoma(30;1.14e-05)|GBM - Glioblastoma multiforme(59;0.000107)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.16)		CATCTTGCAAAGACAGTGCCC	0.428000													43	318					0	0	1	0	0
SECISBP2L	9728	broad.mit.edu	37	15	49320677	49320677	+	Silent	SNP	C	C	T			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr15:49320677C>T	ENST00000559471.1	-	5	1130	c.867G>A	c.(865-867)ttG>ttA	p.L289L	SECISBP2L_ENST00000261847.3_Silent_p.L289L	NM_001193489.1	NP_001180418.1	Q93073	SBP2L_HUMAN	SECIS binding protein 2-like	289										breast(1)|endometrium(5)|kidney(8)|large_intestine(12)|lung(11)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|urinary_tract(1)	46						CAGGATTTCTCAAAGCCCCTG	0.438000													6	91					0	0	1	0	0
KRT18	3875	broad.mit.edu	37	12	53346617	53346617	+	Silent	SNP	G	G	C			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr12:53346617G>C	ENST00000388835.3	+	7	1494	c.1284G>C	c.(1282-1284)ctG>ctC	p.L428L	KRT18_ENST00000388837.2_Silent_p.L428L	NM_000224.2	NP_000215.1	P05783	K1C18_HUMAN	keratin 18	428	Tail.				anatomical structure morphogenesis|cell cycle|Golgi to plasma membrane CFTR protein transport|interspecies interaction between organisms|negative regulation of apoptosis	centriolar satellite|keratin filament|perinuclear region of cytoplasm	protein binding|structural molecule activity			central_nervous_system(1)|large_intestine(2)|lung(4)|prostate(3)|skin(1)	11						CCAAAGTTCTGAGGCATTAAG	0.493000													7	73					0	0	1	0	0
FANCI	55215	broad.mit.edu	37	15	89843089	89843089	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr15:89843089G>A	ENST00000310775.7	+	25	2781	c.2695G>A	c.(2695-2697)Gag>Aag	p.E899K	FANCI_ENST00000300027.8_Missense_Mutation_p.E839K	NM_001113378.1	NP_001106849.1	Q9NVI1	FANCI_HUMAN	Fanconi anemia, complementation group I	899					cell cycle|DNA repair	nucleoplasm	protein binding			breast(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(7)|ovary(2)|pancreas(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	31	Lung NSC(78;0.0472)|all_lung(78;0.089)					GGGAAAGAAAGAGAAAGGAAA	0.423000								Involved in tolerance or repair of DNA crosslinks	Fanconi Anemia				10	84					0	0	1	0	0
GALNT15	117248	broad.mit.edu	37	3	16254169	16254169	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr3:16254169G>A	ENST00000339732.5	+	6	1794	c.1291G>A	c.(1291-1293)Gag>Aag	p.E431K	GALNT15_ENST00000437509.1_Missense_Mutation_p.E431K	NM_054110.4	NP_473451.3			UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 15																		CCTCGACCAGGAGGCCACCCT	0.557000													7	101					0	0	1	0	0
MAP3K3	4215	broad.mit.edu	37	17	61767679	61767679	+	Silent	SNP	C	C	T			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr17:61767679C>T	ENST00000361357.3	+	13	1530	c.1212C>T	c.(1210-1212)ttC>ttT	p.F404F	MAP3K3_ENST00000577395.1_Silent_p.F369F|MAP3K3_ENST00000361733.3_Silent_p.F373F|MAP3K3_ENST00000579585.1_Silent_p.F404F|MAP3K3_ENST00000584573.1_Silent_p.F400F	NM_203351.1	NP_976226.1	Q99759	M3K3_HUMAN	mitogen-activated protein kinase kinase kinase 3	373	Protein kinase.				MAPKKK cascade|positive regulation of I-kappaB kinase/NF-kappaB cascade|protein autophosphorylation	cytosol	ATP binding|MAP kinase kinase kinase activity|metal ion binding|protein binding			breast(1)|endometrium(4)|kidney(2)|large_intestine(6)|lung(10)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	28						AGGGTGCCTTCGGCAGGGTCT	0.527000													11	117					0	0	1	0	0
ATF6B	1388	broad.mit.edu	37	6	32085106	32085106	+	Silent	SNP	C	C	T			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr6:32085106C>T	ENST00000375201.4	-	14	1644	c.1599G>A	c.(1597-1599)gaG>gaA	p.E533E	ATF6B_ENST00000375203.3_Silent_p.E536E			Q99941	ATF6B_HUMAN	activating transcription factor 6 beta	536					response to unfolded protein|signal transduction	endoplasmic reticulum membrane|integral to membrane|nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(11)|prostate(2)|skin(1)|urinary_tract(1)	22						CTACCTGTCTCTCCTGGGCCC	0.597000													5	36					0	0	1	0	0
PFKP	5214	broad.mit.edu	37	10	3154456	3154456	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr10:3154456G>C	ENST00000381075.2	+	13	1332	c.1108G>C	c.(1108-1110)Gat>Cat	p.D370H	PFKP_ENST00000381125.4_Missense_Mutation_p.D378H	NM_001242339.1	NP_001229268.1	Q01813	K6PP_HUMAN	phosphofructokinase, platelet	378					glycolysis	6-phosphofructokinase complex	6-phosphofructokinase activity|ATP binding|metal ion binding|protein binding			breast(2)|central_nervous_system(4)|endometrium(3)|large_intestine(3)|lung(10)|ovary(2)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	31				GBM - Glioblastoma multiforme(1;0.000975)|all cancers(11;0.00351)|Epithelial(11;0.142)		GAGATTTCAAGATGCGGTTCG	0.512000													5	73					0	0	1	0	0
TRIM27	5987	broad.mit.edu	37	6	28872323	28872323	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr6:28872323G>T	ENST00000377199.3	-	8	1422	c.1066C>A	c.(1066-1068)Ctg>Atg	p.L356M	TRIM27_ENST00000377194.3_Intron	NM_006510.4	NP_006501.1	P14373	TRI27_HUMAN	tripartite motif containing 27	356	B30.2/SPRY.				cell proliferation|negative regulation of gene expression, epigenetic|negative regulation of transcription from RNA polymerase II promoter|protein trimerization|spermatogenesis|transcription, DNA-dependent	cytoplasm|integral to plasma membrane|membrane fraction|nuclear membrane|PML body	DNA binding|protein binding|transmembrane receptor protein tyrosine kinase activity|zinc ion binding			endometrium(1)|large_intestine(2)|lung(6)|ovary(1)	10						CAGGGAAACAGATTGAACCTC	0.542000			T	RET	papillary thyroid								10	45					0.00621372	0.00627179	1	1	0
OR4K1	79544	broad.mit.edu	37	14	20404108	20404108	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr14:20404108G>C	ENST00000285600.4	+	1	342	c.283G>C	c.(283-285)Gag>Cag	p.E95Q		NM_001004063.2	NP_001004063.2	Q8NGD4	OR4K1_HUMAN	olfactory receptor, family 4, subfamily K, member 1	95					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|lung(24)|ovary(1)|pancreas(1)|skin(3)|upper_aerodigestive_tract(1)	43	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00124)		TATCTCCTTTGAGGGTTGCAT	0.403000													5	442					0	0	1	0	0
CDH16	1014	broad.mit.edu	37	16	66951592	66951592	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr16:66951592C>T	ENST00000299752.4	-	3	275	c.82G>A	c.(82-84)Gaa>Aaa	p.E28K	CDH16_ENST00000565796.1_Missense_Mutation_p.E28K|CDH16_ENST00000568632.1_Missense_Mutation_p.E28K|CDH16_ENST00000570262.1_Intron|CDH16_ENST00000394055.3_Missense_Mutation_p.E28K	NM_001204744.1|NM_001204745.1|NM_004062.3	NP_001191673.1|NP_001191674.1|NP_004053.1	O75309	CAD16_HUMAN	cadherin 16, KSP-cadherin	28	Cadherin 1.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			endometrium(1)|kidney(3)|large_intestine(10)|lung(15)|ovary(2)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	41		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0877)|Epithelial(162;0.203)		TCTGGAACTTCCACAGACAGC	0.582000													4	22					0	0	1	0	0
ARHGAP31	57514	broad.mit.edu	37	3	119133435	119133435	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr3:119133435G>C	ENST00000264245.4	+	12	3191	c.2659G>C	c.(2659-2661)Gac>Cac	p.D887H		NM_020754.2	NP_065805.2	Q2M1Z3	RHG31_HUMAN	Rho GTPase activating protein 31	887					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|focal adhesion|lamellipodium	GTPase activator activity			breast(5)|central_nervous_system(1)|cervix(1)|endometrium(10)|kidney(3)|large_intestine(11)|lung(29)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	67						GGAGCCTTCAGACTGTGACGA	0.552000													4	106					0	0	1	0	0
CAPN2	824	broad.mit.edu	37	1	223943283	223943283	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr1:223943283C>G	ENST00000295006.5	+	10	1546	c.1237C>G	c.(1237-1239)Cag>Gag	p.Q413E	CAPN2_ENST00000433674.2_Missense_Mutation_p.Q335E	NM_001748.4	NP_001739.2	P17655	CAN2_HUMAN	calpain 2, (m/II) large subunit	413	Domain III.				proteolysis	cytoplasm|plasma membrane				breast(3)|endometrium(1)|kidney(1)|large_intestine(9)|lung(10)|prostate(1)|skin(1)|stomach(3)	29				GBM - Glioblastoma multiforme(131;0.109)		GGGGCTCATTCAGAAGCACCG	0.607000													4	35					0	0	1	0	0
PPL	5493	broad.mit.edu	37	16	4937178	4937178	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr16:4937178C>G	ENST00000345988.2	-	21	2654	c.2565G>C	c.(2563-2565)caG>caC	p.Q855H	PPL_ENST00000590782.2_Missense_Mutation_p.Q853H	NM_002705.4	NP_002696.3	O60437	PEPL_HUMAN	periplakin	855					keratinization	cytoskeleton|desmosome|mitochondrion|nucleus	protein binding|structural constituent of cytoskeleton			breast(6)|central_nervous_system(1)|endometrium(11)|kidney(5)|large_intestine(12)|lung(12)|ovary(4)|prostate(5)|skin(3)|stomach(1)|urinary_tract(2)	62						TCTGCAGCCTCTGTCTGTTGA	0.463000													17	275					0	0	1	0	0
SEC31A	22872	broad.mit.edu	37	4	83784530	83784530	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr4:83784530C>T	ENST00000432794.1	-	12	1613	c.1450G>A	c.(1450-1452)Gat>Aat	p.D484N	SEC31A_ENST00000508479.1_Missense_Mutation_p.D484N|SEC31A_ENST00000436790.2_5'UTR|SEC31A_ENST00000326950.5_Missense_Mutation_p.D484N|SEC31A_ENST00000505472.1_Missense_Mutation_p.D484N|SEC31A_ENST00000448323.1_Missense_Mutation_p.D484N|SEC31A_ENST00000505984.1_Missense_Mutation_p.D484N|SEC31A_ENST00000508502.1_Missense_Mutation_p.D484N|SEC31A_ENST00000395310.2_Missense_Mutation_p.D484N|SEC31A_ENST00000355196.2_Missense_Mutation_p.D484N|SEC31A_ENST00000264405.5_Missense_Mutation_p.D256N|SEC31A_ENST00000443462.2_Missense_Mutation_p.D479N|SEC31A_ENST00000348405.4_Missense_Mutation_p.D484N|SEC31A_ENST00000500777.2_Missense_Mutation_p.D484N|SEC31A_ENST00000311785.7_Missense_Mutation_p.D484N|SEC31A_ENST00000513858.1_Missense_Mutation_p.D484N|SEC31A_ENST00000509142.1_Missense_Mutation_p.D484N			O94979	SC31A_HUMAN	SEC31 homolog A (S. cerevisiae)	484					COPII vesicle coating|post-translational protein modification|protein N-linked glycosylation via asparagine|protein transport|response to calcium ion	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|perinuclear region of cytoplasm	calcium-dependent protein binding		SEC31A/ALK(3)|SEC31A/JAK2(4)	breast(1)	1		Hepatocellular(203;0.114)				CCACGAGAATCATCCTCAAAG	0.308000													7	138					0	0	1	0	0
FAM13B	51306	broad.mit.edu	37	5	137342716	137342716	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr5:137342716C>T	ENST00000033079.3	-	7	1262	c.811G>A	c.(811-813)Gaa>Aaa	p.E271K	FAM13B_ENST00000420893.2_Missense_Mutation_p.E271K|FAM13B_ENST00000425075.2_Missense_Mutation_p.E153K	NM_016603.2	NP_057687.2	Q9NYF5	FA13B_HUMAN	family with sequence similarity 13, member B	271					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			endometrium(4)|kidney(2)|lung(5)	11						AGGATGTTTTCAGTCATCCTT	0.378000													7	136					0	0	1	0	0
ARMC7	79637	broad.mit.edu	37	17	73106605	73106605	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr17:73106605C>A	ENST00000245543.1	+	2	441	c.139C>A	c.(139-141)Ccc>Acc	p.P47T	ARMC7_ENST00000582136.1_Missense_Mutation_p.P47T|ARMC7_ENST00000581078.1_Missense_Mutation_p.P47T|ARMC7_ENST00000584947.1_Missense_Mutation_p.P47T	NM_024585.2	NP_078861.1	Q9H6L4	ARMC7_HUMAN	armadillo repeat containing 7	47							binding			breast(2)|haematopoietic_and_lymphoid_tissue(1)|lung(3)|pancreas(3)	9	all_lung(278;0.14)|Lung NSC(278;0.168)		LUSC - Lung squamous cell carcinoma(166;0.162)|Lung(188;0.235)			CGCTTATGACCCCAGCAACTA	0.577000													7	96					0.000157383	0.000160051	1	1	0
WHAMMP3	339005	broad.mit.edu	37	15	23205193	23205193	+	RNA	SNP	A	A	G			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr15:23205193A>G	ENST00000400153.2	-	0	661					NR_003521.1																						GGTGTCCTTGAATAACCTAGA	0.398000													3	28					0	0	1	0	0
ECD	11319	broad.mit.edu	37	10	74914175	74914175	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr10:74914175G>A	ENST00000372979.4	-	6	828	c.622C>T	c.(622-624)Cga>Tga	p.R208*	ECD_ENST00000430082.1_Nonsense_Mutation_p.R208*|ECD_ENST00000454759.1_Nonsense_Mutation_p.R208*	NM_007265.2	NP_009196.1	O95905	SGT1_HUMAN	ecdysoneless homolog (Drosophila)	208					regulation of glycolysis|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|nucleus	transcription coactivator activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(5)|pancreas(1)|prostate(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	21	Prostate(51;0.0119)					CAGTGTGCTCGATGAAGTGAG	0.443000													5	63					0	0	1	0	0
ADAMTS10	81794	broad.mit.edu	37	19	8656945	8656945	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr19:8656945C>T	ENST00000270328.4	-	13	1896	c.1630G>A	c.(1630-1632)Gag>Aag	p.E544K	ADAMTS10_ENST00000595838.1_Silent_p.Q34Q|ADAMTS10_ENST00000597188.1_Missense_Mutation_p.E544K			Q9H324	ATS10_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 10	544	Disintegrin.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(2)|kidney(16)|large_intestine(5)|lung(9)|ovary(1)|pancreas(2)|prostate(3)|skin(10)|urinary_tract(1)	53						TCCACACCCTCTGGGCGCGAC	0.687000													4	56					0	0	1	0	0
SLC39A10	57181	broad.mit.edu	37	2	196571476	196571476	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr2:196571476G>A	ENST00000409086.3	+	4	1628	c.1353G>A	c.(1351-1353)atG>atA	p.M451I	SLC39A10_ENST00000541054.1_Start_Codon_SNP_p.M1I|SLC39A10_ENST00000359634.5_Missense_Mutation_p.M451I	NM_001127257.1	NP_001120729.1	Q9ULF5	S39AA_HUMAN	solute carrier family 39 (zinc transporter), member 10	451					zinc ion transport	integral to membrane	metal ion transmembrane transporter activity			breast(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(5)|liver(1)|lung(16)|pancreas(1)|prostate(1)|skin(2)	34			OV - Ovarian serous cystadenocarcinoma(117;0.221)			TAGGAACAATGAGTGGAGACG	0.368000													15	157					0	0	1	0	0
EPB41L5	57669	broad.mit.edu	37	2	120885271	120885271	+	Silent	SNP	C	C	T			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr2:120885271C>T	ENST00000263713.5	+	17	1559	c.1345C>T	c.(1345-1347)Ctg>Ttg	p.L449L	EPB41L5_ENST00000452780.1_Silent_p.L449L|EPB41L5_ENST00000443902.2_Silent_p.L449L	NM_020909.3	NP_065960.2	Q9HCM4	E41L5_HUMAN	erythrocyte membrane protein band 4.1 like 5	449						cytoplasm|cytoskeleton|extrinsic to membrane	cytoskeletal protein binding			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(5)|lung(12)|ovary(1)	26						CAGCATTCCTCTGAATATTGA	0.373000													8	189					0	0	1	0	0
ZNF660	285349	broad.mit.edu	37	3	44635767	44635767	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr3:44635767G>A	ENST00000322734.2	+	3	415	c.82G>A	c.(82-84)Gaa>Aaa	p.E28K	RP11-944L7.4_ENST00000457331.1_RNA	NM_173658.2	NP_775929.2	Q6AZW8	ZN660_HUMAN	zinc finger protein 660	28					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(2)|lung(4)	6				KIRC - Kidney renal clear cell carcinoma(197;0.0468)|Kidney(197;0.0585)		CCAAGAATCTGAAAAAGACAA	0.393000													6	88					0	0	1	0	0
ANK2	287	broad.mit.edu	37	4	114276810	114276810	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr4:114276810G>C	ENST00000357077.4	+	38	7089	c.7036G>C	c.(7036-7038)Gag>Cag	p.E2346Q	ANK2_ENST00000506722.1_Intron|ANK2_ENST00000394537.3_Intron|ANK2_ENST00000509550.1_Intron|ANK2_ENST00000264366.6_Missense_Mutation_p.E2313Q|ANK2_ENST00000510275.2_Intron	NM_001148.4	NP_001139.3	Q01484	ANK2_HUMAN	ankyrin 2, neuronal	2313					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding			NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(10)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(54)|liver(2)|lung(112)|ovary(8)|pancreas(1)|prostate(7)|skin(11)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(10)	248		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		ACTGACTGAGGAGGCAGCCTG	0.488000													4	47					0	0	1	0	0
IQGAP3	128239	broad.mit.edu	37	1	156502888	156502888	+	Silent	SNP	G	G	A	rs139057334		TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr1:156502888G>A	ENST00000361170.2	-	32	3997	c.3987C>T	c.(3985-3987)atC>atT	p.I1329I		NM_178229.4	NP_839943.2	Q86VI3	IQGA3_HUMAN	IQ motif containing GTPase activating protein 3	1329					small GTPase mediated signal transduction	intracellular	calmodulin binding|Ras GTPase activator activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(8)|kidney(2)|large_intestine(14)|lung(29)|ovary(5)|prostate(5)|skin(5)|urinary_tract(3)	75	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					CATCTGCAGCGATGCTCTCAC	0.547000													17	148					0	0	1	0	0
FN1	2335	broad.mit.edu	37	2	216274733	216274733	+	Silent	SNP	G	G	A			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr2:216274733G>A	ENST00000354785.4	-	14	2415	c.2046C>T	c.(2044-2046)atC>atT	p.I682I	FN1_ENST00000323926.6_Silent_p.I682I|FN1_ENST00000345488.5_Silent_p.I682I|FN1_ENST00000336916.4_Silent_p.I682I|FN1_ENST00000357009.2_Silent_p.I682I|FN1_ENST00000446046.1_Silent_p.I682I|FN1_ENST00000432072.2_Silent_p.I682I|FN1_ENST00000443816.1_Silent_p.I682I|FN1_ENST00000346544.3_Silent_p.I682I|FN1_ENST00000359671.1_Silent_p.I682I|FN1_ENST00000357867.4_Silent_p.I682I|FN1_ENST00000421182.1_Silent_p.I682I|FN1_ENST00000356005.4_Silent_p.I682I			P02751	FINC_HUMAN	fibronectin 1	682	Fibronectin type-III 1.				acute-phase response|angiogenesis|leukocyte migration|peptide cross-linking|platelet activation|platelet degranulation|regulation of cell shape|substrate adhesion-dependent cell spreading	ER-Golgi intermediate compartment|fibrinogen complex|platelet alpha granule lumen|proteinaceous extracellular matrix	collagen binding|extracellular matrix structural constituent|heparin binding		FN1/ALK(2)	NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(7)|endometrium(9)|kidney(8)|large_intestine(33)|lung(38)|ovary(1)|pancreas(1)|prostate(3)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)	109		Renal(323;0.127)		Epithelial(149;9.59e-07)|all cancers(144;0.000174)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)	Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GCTGGATGCTGATGAGCTGGC	0.537000													7	140					0	0	1	0	0
ZNF91	7644	broad.mit.edu	37	19	23543349	23543349	+	Nonsense_Mutation	SNP	G	G	C			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr19:23543349G>C	ENST00000300619.7	-	4	2637	c.2432C>G	c.(2431-2433)tCa>tGa	p.S811*	ZNF91_ENST00000397082.2_Nonsense_Mutation_p.S779*|ZNF91_ENST00000599743.1_Intron	NM_003430.2	NP_003421.2	Q05481	ZNF91_HUMAN	zinc finger protein 91	811						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding						all_lung(12;0.0349)|Lung NSC(12;0.0538)|all_epithelial(12;0.0611)				AGTAAGGGTTGAGGAACGGCT	0.408000													4	128					0	0	1	0	0
KMT2A	4297	broad.mit.edu	37	11	118344632	118344632	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr11:118344632G>C	ENST00000534358.1	+	3	2781	c.2758G>C	c.(2758-2760)Gat>Cat	p.D920H	KMT2A_ENST00000389506.5_Missense_Mutation_p.D920H|KMT2A_ENST00000354520.4_Missense_Mutation_p.D920H	NM_001197104.1|NM_005933.3	NP_001184033.1|NP_005924.2			lysine (K)-specific methyltransferase 2A									p.D920Y(2)									TGTTGGTGAAGATGTTGCCAC	0.433000													7	104					0	0	1	0	0
OR8H3	390152	broad.mit.edu	37	11	55890051	55890051	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr11:55890051C>T	ENST00000313472.3	+	1	203	c.203C>T	c.(202-204)tCa>tTa	p.S68L		NM_001005201.1	NP_001005201.1	Q8N146	OR8H3_HUMAN	olfactory receptor, family 8, subfamily H, member 3	68					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.S68*(1)		endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(30)|ovary(2)|prostate(1)|skin(3)|stomach(1)	42	Esophageal squamous(21;0.00693)					ACTCACCTGTCATTTATTGAC	0.438000													18	391					0	0	1	0	0
ARFGAP3	26286	broad.mit.edu	37	22	43230262	43230262	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr22:43230262G>A	ENST00000263245.5	-	5	682	c.463C>T	c.(463-465)Cac>Tac	p.H155Y	ARFGAP3_ENST00000437119.2_Missense_Mutation_p.H111Y|ARFGAP3_ENST00000429508.2_Intron	NM_001142293.1|NM_014570.4	NP_001135765.1|NP_055385.3	Q9NP61	ARFG3_HUMAN	ADP-ribosylation factor GTPase activating protein 3	155					intracellular protein transport|protein secretion|regulation of ARF GTPase activity|vesicle-mediated transport	cytosol|Golgi membrane	ARF GTPase activator activity|protein transporter activity|zinc ion binding			breast(3)|endometrium(1)|kidney(1)|large_intestine(3)|lung(2)|ovary(1)	11						GGAGAAACGTGAGAGGCAAAA	0.408000													8	195					0	0	1	0	0
DAXX	1616	broad.mit.edu	37	6	33287244	33287244	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr6:33287244G>A	ENST00000374542.5	-	6	2057	c.1853C>T	c.(1852-1854)tCt>tTt	p.S618F	DAXX_ENST00000414083.2_Missense_Mutation_p.S543F|DAXX_ENST00000266000.6_Missense_Mutation_p.S618F	NM_001141969.1|NM_001141970.1|NM_001350.4	NP_001135441.1|NP_001135442.1|NP_001341.1	Q9UER7	DAXX_HUMAN	death-domain associated protein	618	Interaction with MAP3K5.				activation of JUN kinase activity|androgen receptor signaling pathway|apoptosis|induction of apoptosis via death domain receptors|interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|regulation of protein ubiquitination|transcription, DNA-dependent	chromosome, centromeric region|cytosol|nucleolus|PML body	androgen receptor binding|heat shock protein binding|p53 binding|protein homodimerization activity|protein N-terminus binding|receptor signaling protein activity|transcription factor binding|ubiquitin protein ligase binding			breast(1)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(2)|lung(7)|ovary(3)|pancreas(18)|prostate(3)|skin(4)|upper_aerodigestive_tract(4)|urinary_tract(1)	55						GTTGTGAGGAGAGACGCCTCC	0.493000			"""Mis, F, N"""		Pancreatic neuroendocrine tumors. Paediatric GBM								4	145					0	0	1	0	0
RHOBTB1	9886	broad.mit.edu	37	10	62648292	62648292	+	Silent	SNP	G	G	A			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr10:62648292G>A	ENST00000337910.5	-	6	1471	c.1134C>T	c.(1132-1134)ttC>ttT	p.F378F	RHOBTB1_ENST00000357917.4_Silent_p.F378F	NM_001242359.1|NM_014836.4	NP_001229288.1|NP_055651.1	O94844	RHBT1_HUMAN	Rho-related BTB domain containing 1	378	BTB 1.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|plasma membrane	GTP binding			endometrium(4)|large_intestine(6)|lung(11)|ovary(1)|upper_aerodigestive_tract(1)	23	Prostate(12;0.0112)					GCATGCCAATGAACCCCTTAC	0.557000													6	110					0	0	1	0	0
CD209	30835	broad.mit.edu	37	19	7812273	7812273	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr19:7812273C>T	ENST00000593660.1	-	1	124	c.25G>A	c.(25-27)Gat>Aat	p.D9N	CD209_ENST00000315591.8_Intron|CD209_ENST00000315599.7_Intron|CD209_ENST00000601256.1_Missense_Mutation_p.D9N|CD209_ENST00000354397.6_Intron|CD209_ENST00000394161.5_Intron|CD209_ENST00000593821.1_Intron|CD209_ENST00000301357.8_Intron|CD209_ENST00000601951.1_Missense_Mutation_p.D9N|CD209_ENST00000394173.4_Intron|CD209_ENST00000204801.8_Intron|CD209_ENST00000602261.1_Intron			Q9NNX6	CD209_HUMAN	CD209 molecule	0					cell-cell recognition|endocytosis|heterophilic cell-cell adhesion|innate immune response|intracellular signal transduction|intracellular virion transport|leukocyte cell-cell adhesion|peptide antigen transport|viral genome replication|virion attachment to host cell surface receptor	cytoplasm|extracellular region|integral to membrane|plasma membrane	mannose binding|metal ion binding|peptide antigen binding|receptor activity|virion binding			endometrium(7)|kidney(3)|large_intestine(6)|lung(10)|ovary(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	35						GACGTGAAATCAGAGCCTGGG	0.587000													19	333					0	0	1	0	0
ZCCHC5	203430	broad.mit.edu	37	X	77913882	77913882	+	Silent	SNP	C	C	T			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chrX:77913882C>T	ENST00000321110.1	-	2	331	c.36G>A	c.(34-36)ctG>ctA	p.L12L		NM_152694.2	NP_689907.1	Q8N8U3	ZCHC5_HUMAN	zinc finger, CCHC domain containing 5	12							nucleic acid binding|zinc ion binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(6)|lung(18)|ovary(1)|prostate(1)|skin(1)	37						TCTCCAATTTCAGAACAATAT	0.473000													3	23					0	0	1	0	0
SERPINA5	5104	broad.mit.edu	37	14	95058471	95058471	+	Silent	SNP	C	C	T			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr14:95058471C>T	ENST00000329597.7	+	6	1326	c.1116C>T	c.(1114-1116)ttC>ttT	p.F372F	SERPINA5_ENST00000554276.1_Silent_p.F372F|SERPINA5_ENST00000554866.1_Silent_p.F372F|SERPINA5_ENST00000553780.1_Silent_p.F372F|SERPINA3_ENST00000553947.1_5'UTR	NM_000624.4	NP_000615.3	P05154	IPSP_HUMAN	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5	372					fusion of sperm to egg plasma membrane|regulation of proteolysis|spermatogenesis	extracellular region|membrane|protein complex	acrosin binding|heparin binding|protease binding|serine-type endopeptidase inhibitor activity			endometrium(3)|large_intestine(5)|lung(18)|ovary(2)|skin(5)|upper_aerodigestive_tract(3)	36				COAD - Colon adenocarcinoma(157;0.21)	Drotrecogin alfa(DB00055)|Urokinase(DB00013)	TATTCACTTTCAGGTCGGCCC	0.557000													20	405					0	0	1	0	0
BCO2	83875	broad.mit.edu	37	11	112065459	112065459	+	Silent	SNP	G	G	T			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr11:112065459G>T	ENST00000357685.5	+	5	852	c.717G>T	c.(715-717)ggG>ggT	p.G239G	BCO2_ENST00000532593.1_Silent_p.G134G|BCO2_ENST00000438022.1_Silent_p.G205G|BCO2_ENST00000361053.4_Intron|SDHD_ENST00000532612.1_Intron|BCO2_ENST00000393032.2_Silent_p.G205G|BCO2_ENST00000531169.1_Silent_p.G205G|BCO2_ENST00000526088.1_Silent_p.G205G			Q9BYV7	BCDO2_HUMAN	beta-carotene oxygenase 2	239					carotene metabolic process|retinal metabolic process|retinoic acid metabolic process		metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			NS(1)|breast(1)|kidney(3)|large_intestine(1)|lung(9)|skin(1)	16						ACAATATGGGGAACTCCTTTG	0.393000													7	138					1.12685e-05	1.14811e-05	1	1	0
DLGAP1	9229	broad.mit.edu	37	18	3879988	3879988	+	Silent	SNP	G	G	A			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr18:3879988G>A	ENST00000315677.3	-	4	676	c.81C>T	c.(79-81)tcC>tcT	p.S27S	DLGAP1_ENST00000581527.1_Silent_p.S27S|DLGAP1_ENST00000584874.1_Silent_p.S27S|DLGAP1_ENST00000515196.2_Silent_p.S27S|DLGAP1-AS3_ENST00000577649.1_RNA	NM_004746.3	NP_004737.2	O14490	DLGP1_HUMAN	discs, large (Drosophila) homolog-associated protein 1	27					synaptic transmission	cell junction|postsynaptic density|postsynaptic membrane				breast(2)|endometrium(3)|kidney(1)|large_intestine(5)|lung(31)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(6)|urinary_tract(1)	56		Colorectal(8;0.0257)				GCTTGCGGTCGGAGTGGTGCG	0.667000													10	70					0	0	1	0	0
C15orf39	56905	broad.mit.edu	37	15	75498768	75498768	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr15:75498768C>G	ENST00000360639.2	+	2	699	c.379C>G	c.(379-381)Ctg>Gtg	p.L127V	C15orf39_ENST00000394987.4_Missense_Mutation_p.L127V|C15orf39_ENST00000567617.1_Missense_Mutation_p.L127V			Q6ZRI6	CO039_HUMAN	chromosome 15 open reading frame 39	127										autonomic_ganglia(1)|breast(2)|endometrium(3)|large_intestine(4)|lung(4)|skin(1)|upper_aerodigestive_tract(1)	16						AGGCCCACCACTGGCAGCACC	0.607000													4	41					0	0	1	0	0
MECR	51102	broad.mit.edu	37	1	29542604	29542604	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr1:29542604C>T	ENST00000373791.3	-	3	463	c.91G>A	c.(91-93)Gaa>Aaa	p.E31K	MECR_ENST00000489248.1_5'UTR|MECR_ENST00000263702.6_Missense_Mutation_p.E107K	NM_001024732.1|NM_016011.2	NP_001019903.1|NP_057095.2	Q9BV79	MECR_HUMAN	mitochondrial trans-2-enoyl-CoA reductase	107					fatty acid biosynthetic process	mitochondrion	trans-2-enoyl-CoA reductase (NADPH) activity|zinc ion binding			NS(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(1)|ovary(2)|prostate(1)	11		Colorectal(325;0.000389)|Breast(348;0.00765)|Lung NSC(340;0.0081)|all_lung(284;0.00914)|all_neural(195;0.0199)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)|Medulloblastoma(700;0.123)		Colorectal(126;3.39e-07)|COAD - Colon adenocarcinoma(152;2.04e-05)|STAD - Stomach adenocarcinoma(196;0.0195)|BRCA - Breast invasive adenocarcinoma(304;0.053)|READ - Rectum adenocarcinoma(331;0.0649)|KIRC - Kidney renal clear cell carcinoma(1967;0.137)		GCAACACCTTCGTTCCCTCCA	0.527000													6	103					0	0	1	0	0
PYCR2	29920	broad.mit.edu	37	1	226108948	226108948	+	Silent	SNP	G	G	A			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr1:226108948G>A	ENST00000343818.6	-	6	905	c.757C>T	c.(757-759)Ctg>Ttg	p.L253L	RP4-559A3.7_ENST00000432920.2_Silent_p.L179L|PYCR2_ENST00000478402.1_5'UTR	NM_013328.2	NP_037460.2	Q96C36	P5CR2_HUMAN	pyrroline-5-carboxylate reductase family, member 2	253					proline biosynthetic process	cytoplasm	binding|pyrroline-5-carboxylate reductase activity			kidney(1)|lung(3)	4	Breast(184;0.197)				L-Proline(DB00172)|NADH(DB00157)	TTGATGAGCAGAGAGCGGAAG	0.602000													5	41					0	0	1	0	0
OR2B6	26212	broad.mit.edu	37	6	27925696	27925696	+	Silent	SNP	G	G	A			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr6:27925696G>A	ENST00000244623.1	+	1	678	c.678G>A	c.(676-678)ttG>ttA	p.L226L		NM_012367.1	NP_036499.1	P58173	OR2B6_HUMAN	olfactory receptor, family 2, subfamily B, member 6	226					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|large_intestine(3)|lung(12)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	19						GAGCAGTATTGAGGATACAGT	0.428000													8	234					0	0	1	0	0
ZNF112	7665	broad.mit.edu	37	19	44833880	44833880	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr19:44833880G>A	ENST00000354340.4	-	4	481	c.430C>T	c.(430-432)Cag>Tag	p.Q144*	ZNF112_ENST00000337401.4_Nonsense_Mutation_p.Q150*|CTC-512J12.6_ENST00000588212.1_Nonsense_Mutation_p.Q149*|ZNF112_ENST00000536500.1_Nonsense_Mutation_p.Q167*	NM_013380.3	NP_037512.3			zinc finger protein 112																		TCAGAAATCTGAACTGGTATT	0.393000													5	103					0	0	1	0	0
OR4C12	283093	broad.mit.edu	37	11	50003584	50003584	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr11:50003584G>A	ENST00000335238.4	-	1	487	c.454C>T	c.(454-456)Ctt>Ttt	p.L152F		NM_001005270.2	NP_001005270.1	Q96R67	OR4CC_HUMAN	olfactory receptor, family 4, subfamily C, member 12	152					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|kidney(4)|large_intestine(3)|liver(1)|lung(19)|ovary(2)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	36						GTTGCATGAAGAAATCCTCCC	0.483000													11	239					0	0	1	0	0
SMAD3	4088	broad.mit.edu	37	15	67477138	67477138	+	Silent	SNP	C	C	G			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr15:67477138C>G	ENST00000327367.4	+	7	1255	c.945C>G	c.(943-945)gtC>gtG	p.V315V	SMAD3_ENST00000540846.2_Silent_p.V210V|SMAD3_ENST00000439724.3_Silent_p.V271V|SMAD3_ENST00000537194.2_Silent_p.V120V	NM_005902.3	NP_005893.1	P84022	SMAD3_HUMAN	SMAD family member 3	315	MH2.|Sufficient for interaction with XPO4.				activation of caspase activity|cell cycle arrest|cell-cell junction organization|evasion of host defenses by virus|immune response|induction of apoptosis|negative regulation of cell growth|negative regulation of mitotic cell cycle|negative regulation of protein catabolic process|negative regulation of protein phosphorylation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of catenin import into nucleus|positive regulation of epithelial to mesenchymal transition|positive regulation of transcription factor import into nucleus|positive regulation of transcription from RNA polymerase II promoter|primary miRNA processing|protein stabilization|regulation of transforming growth factor beta receptor signaling pathway|regulation of transforming growth factor-beta2 production|response to hypoxia|SMAD protein complex assembly|transforming growth factor beta receptor signaling pathway|transport|wound healing	cytosol|nuclear inner membrane|receptor complex	beta-catenin binding|co-SMAD binding|metal ion binding|protein homodimerization activity|protein kinase binding|R-SMAD binding|RNA polymerase II activating transcription factor binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transforming growth factor beta receptor binding|transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity|ubiquitin protein ligase binding			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(4)|large_intestine(11)|lung(9)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	31				Colorectal(3;0.0129)|READ - Rectum adenocarcinoma(7;0.125)		CTATTTTTGTCCAGTCTCCCA	0.582000													6	81					0	0	1	0	0
PIK3CA	5290	broad.mit.edu	37	3	178916854	178916854	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr3:178916854G>A	ENST00000263967.3	+	2	398	c.241G>A	c.(241-243)Gaa>Aaa	p.E81K		NM_006218.2	NP_006209.2	P42336	PK3CA_HUMAN	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha	81	PI3K-ABD.				epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.E81K(8)		NS(16)|autonomic_ganglia(4)|biliary_tract(22)|bone(1)|breast(2150)|central_nervous_system(110)|cervix(33)|endometrium(473)|eye(1)|haematopoietic_and_lymphoid_tissue(35)|kidney(14)|large_intestine(1202)|liver(42)|lung(202)|meninges(1)|oesophagus(28)|ovary(235)|pancreas(17)|penis(8)|pituitary(12)|prostate(10)|skin(155)|small_intestine(1)|soft_tissue(18)|stomach(121)|thyroid(80)|upper_aerodigestive_tract(70)|urinary_tract(208)	5269	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			AGAAAGGGAAGAATTTTTTGA	0.358000		57	Mis		"""colorectal, gastric, gliobastoma, breast"""					HNSCC(19;0.045)|TSP Lung(28;0.18)			8	135					0	0	1	0	0
MAP1A	4130	broad.mit.edu	37	15	43815760	43815760	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr15:43815760G>A	ENST00000382031.1	+	5	2834	c.2803G>A	c.(2803-2805)Gag>Aag	p.E935K	MAP1A_ENST00000300231.5_Missense_Mutation_p.E697K|MAP1A_ENST00000399453.1_Missense_Mutation_p.E697K			P78559	MAP1A_HUMAN	microtubule-associated protein 1A	697						cytoplasm|microtubule|microtubule associated complex	protein binding|structural molecule activity			breast(5)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(11)|liver(2)|lung(19)|ovary(5)|pancreas(3)|prostate(2)|skin(6)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	66		all_cancers(109;1.03e-14)|all_epithelial(112;2.23e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.05e-06)	Estramustine(DB01196)	AAGGAGCCGGGAGGCTTTTGG	0.547000													4	38					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179611824	179611824	+	Silent	SNP	C	C	T			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr2:179611824C>T	ENST00000360870.5	-	46	15525	c.15303G>A	c.(15301-15303)gaG>gaA	p.E5101E	TTN_ENST00000591111.1_Intron|TTN_ENST00000589042.1_Intron|TTN_ENST00000460472.2_Intron|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000578746.1_RNA|TTN_ENST00000342175.6_Intron|TTN-AS1_ENST00000590773.1_RNA|TTN_ENST00000359218.5_Intron|TTN_ENST00000342992.6_Intron	NM_133379.3	NP_596870.2	Q8WZ42	TITIN_HUMAN	titin	1209	Ig-like 31.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GCTCTAGAGTCTCTCCTGGGG	0.502000													12	129					0	0	1	0	0
PTER	9317	broad.mit.edu	37	10	16528557	16528557	+	Silent	SNP	C	C	T			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr10:16528557C>T	ENST00000378000.1	+	4	885	c.639C>T	c.(637-639)atC>atT	p.I213I	PTER_ENST00000298942.3_Silent_p.I213I|PTER_ENST00000535784.2_Silent_p.I213I|PTER_ENST00000423462.2_Silent_p.I213I|PTER_ENST00000485788.1_3'UTR	NM_001001484.2|NM_001261838.1|NM_030664.4	NP_001001484.1|NP_001248767.1|NP_109589.2	Q96BW5	PTER_HUMAN	phosphotriesterase related	213					catabolic process		hydrolase activity, acting on ester bonds|zinc ion binding			endometrium(1)|kidney(1)|large_intestine(7)|lung(4)|ovary(2)	15						TTCAGATTATCCGAATATTGC	0.478000													6	98					0	0	1	0	0
AFF3	3899	broad.mit.edu	37	2	100623823	100623823	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr2:100623823G>A	ENST00000317233.4	-	5	509	c.274C>T	c.(274-276)Ctc>Ttc	p.L92F	AFF3_ENST00000409236.1_Missense_Mutation_p.L92F|AFF3_ENST00000409579.1_Missense_Mutation_p.L117F|AFF3_ENST00000356421.2_Missense_Mutation_p.L117F	NM_002285.2	NP_002276.2	P51826	AFF3_HUMAN	AF4/FMR2 family, member 3	92					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(3)|endometrium(9)|kidney(4)|large_intestine(20)|liver(1)|lung(28)|ovary(3)|pancreas(1)|prostate(4)|skin(5)|urinary_tract(3)	86						ACTCCAACGAGATGACTCTGA	0.443000													4	101					0	0	1	0	0
LOXL2	4017	broad.mit.edu	37	8	23160816	23160816	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr8:23160816C>G	ENST00000389131.3	-	11	2344	c.1975G>C	c.(1975-1977)Gag>Cag	p.E659Q		NM_002318.2	NP_002309.1	Q9Y4K0	LOXL2_HUMAN	lysyl oxidase-like 2	659	Lysyl-oxidase like.				aging|cell adhesion|protein modification process	extracellular space|membrane	copper ion binding|electron carrier activity|oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor|scavenger receptor activity			breast(2)|endometrium(4)|kidney(3)|large_intestine(12)|lung(5)|ovary(2)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	35		Prostate(55;0.0453)|Breast(100;0.143)		Colorectal(74;0.0288)|COAD - Colon adenocarcinoma(73;0.096)		TCTGTGTCCTCCAAGCAGAAG	0.597000													4	68					0	0	1	0	0
KIAA0907	22889	broad.mit.edu	37	1	155885709	155885710	+	Frame_Shift_Ins	INS	-	-	T			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr1:155885709_155885710insT	ENST00000368320.3	-	13	1624_1625	c.1599_1600insA	c.(1597-1602)acagtcfs	p.V534fs	KIAA0907_ENST00000368321.3_Frame_Shift_Ins_p.V534fs			Q7Z7F0	K0907_HUMAN	KIAA0907	534										breast(1)|endometrium(2)|kidney(1)|large_intestine(4)|liver(1)|lung(11)|urinary_tract(1)	21	Hepatocellular(266;0.133)|all_hematologic(923;0.145)|all_neural(408;0.195)		OV - Ovarian serous cystadenocarcinoma(3;8.82e-06)			TCATCGGACTCTGTTTTTATTC	0.426													56	428	---	---	---	---					
ANKRD36BP2	645784	broad.mit.edu	37	2	89083945	89083946	+	RNA	INS	-	-	GC			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr2:89083945_89083946insGC	ENST00000393525.3	+	0	576																											GTATTCCTTTTTTTTCAGTGTA	0.347													3	5	---	---	---	---					
STRADB	55437	broad.mit.edu	37	2	202343234	202343234	+	Frame_Shift_Del	DEL	G	G	-			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr2:202343234delG	ENST00000194530.3	+	10	1345	c.980delG	c.(979-981)atfs	p.S327fs	STRADB_ENST00000392249.2_Frame_Shift_Del_p.S327fs	NM_001206864.1|NM_018571.5	NP_001193793.1|NP_061041.2	Q9C0K7	STRAB_HUMAN	STE20-related kinase adaptor beta	327	Protein kinase.				activation of protein kinase activity|cell cycle arrest|insulin receptor signaling pathway|protein export from nucleus|regulation of fatty acid oxidation	cytosol|nucleus	ATP binding|protein binding|protein kinase activity			breast(1)|large_intestine(2)|lung(5)|prostate(1)|skin(3)|stomach(1)	13						ACAGTAAATAGTGACCGATTA	0.423													10	77	---	---	---	---					
HLA-V	352962	broad.mit.edu	37	6	29760353	29760373	+	RNA	DEL	GCGGGCGCCGTGGATGGAGCA	GCGGGCGCCGTGGATGGAGCA	-	rs74661005	by1000genomes	TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr6:29760353_29760373delGCGGGCGCCGTGGATGGAGCA	ENST00000457107.1	+	0	223_243																											GGATGGAGCCGCGGGCGCCGTGGATGGAGCAGGAGGGGCCG	0.674													3	4	---	---	---	---					
ADCK5	203054	broad.mit.edu	37	8	145617535	145617549	+	Splice_Site	DEL	GGGGGTGCAAGGTGA	GGGGGTGCAAGGTGA	-	rs11270020		TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr8:145617535_145617549delGGGGGTGCAAGGTGA	ENST00000308860.6	+	12	1301_1311	c.1267_splice	c.e12+1	p.L419_splice		NM_174922.3	NP_777582.3	Q3MIX3	ADCK5_HUMAN	aarF domain containing kinase 5	419	Protein kinase.					integral to membrane	protein serine/threonine kinase activity	p.?(2)		endometrium(1)|lung(2)|prostate(2)|skin(1)|stomach(2)	8	all_cancers(97;6.64e-12)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;8.96e-41)|Epithelial(56;4.08e-40)|all cancers(56;4.51e-35)|BRCA - Breast invasive adenocarcinoma(115;0.0323)|Colorectal(110;0.055)			CAGCCGCACTGGGGGTGCAAGGTGAGGGGGTGCAA	0.730													3	3	---	---	---	---					
LOC101928823	101928823	broad.mit.edu	37	11	112332121	112332121	+	RNA	DEL	T	T	-			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr11:112332121delT	ENST00000528496.1	+	0	231																											TGATTTTATGTTTTTTTTTTT	0.378													2	4	---	---	---	---					
ROBO3	64221	broad.mit.edu	37	11	124750448	124750453	+	In_Frame_Del	DEL	CGGAGT	CGGAGT	-	rs55725290		TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr11:124750448_124750453delCGGAGT	ENST00000397801.1	+	27	4285_4290	c.4093_4098delCGGAGT	c.(4093-4098)del	p.RS1367del	ROBO3_ENST00000543966.1_In_Frame_Del_p.RS130del|ROBO3_ENST00000538940.1_In_Frame_Del_p.RS1345del|ROBO3_ENST00000525482.1_3'UTR	NM_022370.3	NP_071765.2	Q96MS0	ROBO3_HUMAN	roundabout, axon guidance receptor, homolog 3 (Drosophila)	1367					axon midline choice point recognition	integral to membrane	receptor activity			breast(2)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(17)|ovary(1)|prostate(3)|upper_aerodigestive_tract(1)	35	all_hematologic(175;0.215)	Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|Breast(109;0.0481)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.5e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0296)		TGgccggagccggagtcggagtcaga	0.660													3	6	---	---	---	---					
LRRC63	220416	broad.mit.edu	37	13	46844505	46844505	+	Splice_Site	DEL	C	C	-			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr13:46844505delC	ENST00000446175.1	+	10	1932	c.1588_splice	c.e10+1	p.L529_splice	LRRC63_ENST00000595396.1_Intron					leucine rich repeat containing 63											lung(1)|ovary(1)	2						TTGCACCTCTCTGTAAGATTT	0.428													8	163	---	---	---	---					
SNAI3-AS1	197187	broad.mit.edu	37	16	88734767	88734769	+	RNA	DEL	CCC	CCC	-			TCGA-CN-A6V1-01A-12D-A34J-08	TCGA-CN-A6V1-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79e65f7b-baad-443a-9b93-8d7aab74f090	1de93cac-f6b5-4c6d-b5c1-176fbd48c647	g.chr16:88734767_88734769delCCC	ENST00000563475.1	+	0	21				SNAI3-AS1_ENST00000563261.1_RNA|SNAI3-AS1_ENST00000565633.1_RNA|SNAI3-AS1_ENST00000569786.1_RNA	NR_024402.1																						ctcctgccctccccccatctttt	0.571													2	4	---	---	---	---