Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
KRTAP27-1	643812	broad.mit.edu	37	21	31709410	31709410	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr21:31709410C>G	ENST00000382835.2	-	1	602	c.577G>C	c.(577-579)Gaa>Caa	p.E193Q		NM_001077711.1	NP_001071179.1	Q3LI81	KR271_HUMAN	keratin associated protein 27-1	193						intermediate filament				endometrium(2)|large_intestine(3)|lung(9)|ovary(2)|prostate(1)|skin(1)	18						CAAGTTGGTTCAACTCCTGGA	0.443000													23	24					0	0	0.069288	0	0
FAM71F1	84691	broad.mit.edu	37	7	128359080	128359080	+	Silent	SNP	T	T	A			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr7:128359080T>A	ENST00000315184.5	+	3	683	c.630T>A	c.(628-630)atT>atA	p.I210I	FAM71F1_ENST00000485070.1_Silent_p.I111I|FAM71F1_ENST00000469348.1_3'UTR	NM_032599.2	NP_115988.1	Q96KD3	F71F1_HUMAN	family with sequence similarity 71, member F1	210										NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(6)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	18						ACCCTAGGATTCTTGTCACGC	0.537000													5	108					0	0	0.014758	0	0
ZNF337	26152	broad.mit.edu	37	20	25657009	25657009	+	Silent	SNP	G	G	C			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr20:25657009G>C	ENST00000376436.1	-	4	1454	c.915C>G	c.(913-915)tcC>tcG	p.S305S	ZNF337_ENST00000538750.1_Silent_p.S273S|RP4-694B14.5_ENST00000439498.1_RNA|ZNF337_ENST00000252979.5_Silent_p.S305S|RP4-694B14.5_ENST00000414393.1_RNA|RP4-694B14.5_ENST00000455791.1_RNA					zinc finger protein 337											breast(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(8)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	32						TGTTGTATGAGGACTTATCGT	0.473000													79	127					0	0	0.139131	0	0
RUNX1T1	862	broad.mit.edu	37	8	93027012	93027012	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr8:93027012T>C	ENST00000523629.1	-	4	717	c.263A>G	c.(262-264)aAt>aGt	p.N88S	RUNX1T1_ENST00000396218.1_Missense_Mutation_p.N61S|RUNX1T1_ENST00000436581.2_Missense_Mutation_p.N99S|RUNX1T1_ENST00000360348.2_Missense_Mutation_p.N51S|RUNX1T1_ENST00000265814.3_Missense_Mutation_p.N88S|RUNX1T1_ENST00000520724.1_Missense_Mutation_p.N51S|RUNX1T1_ENST00000521553.1_Missense_Mutation_p.N51S|RUNX1T1_ENST00000422361.2_Missense_Mutation_p.N51S|RUNX1T1_ENST00000518844.1_Missense_Mutation_p.N61S	NM_001198626.1|NM_001198630.1|NM_001198633.1|NM_175634.2	NP_001185555.1|NP_001185559.1|NP_001185562.1|NP_783552.1	Q06455	MTG8_HUMAN	runt-related transcription factor 1; translocated to, 1 (cyclin D-related)	88					generation of precursor metabolites and energy	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(17)|lung(54)|pancreas(1)|skin(3)|upper_aerodigestive_tract(2)	86			BRCA - Breast invasive adenocarcinoma(11;0.0141)			GGGGGCGCCATTCAAGGCTGT	0.517000													3	46					0	0	0.014758	0	0
KIAA0020	9933	broad.mit.edu	37	9	2829887	2829887	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr9:2829887G>A	ENST00000397885.2	-	8	945	c.739C>T	c.(739-741)Cgg>Tgg	p.R247W	KIAA0020_ENST00000469168.1_5'UTR	NM_014878.4	NP_055693.4	Q15397	K0020_HUMAN	KIAA0020	247	PUM-HD.					endoplasmic reticulum|nucleolus	RNA binding			NS(1)|breast(2)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(7)|lung(4)|ovary(1)	21				GBM - Glioblastoma multiforme(50;0.0319)		TCCGCATGCCGCAGCATCTTC	0.438000													5	122					0	0	0.014758	0	0
C1orf173	127254	broad.mit.edu	37	1	75037078	75037078	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr1:75037078C>T	ENST00000326665.5	-	14	4534	c.4316G>A	c.(4315-4317)cGg>cAg	p.R1439Q	C1orf173_ENST00000433746.2_5'UTR	NM_001002912.4	NP_001002912.4	Q5RHP9	CA173_HUMAN	chromosome 1 open reading frame 173	1439	Glu-rich.									NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(23)|lung(123)|ovary(3)|prostate(10)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)	184						TGAGGTCTTCCGCTCCAGGGC	0.612000													14	126					0	0	0.105934	0	0
FOXM1	2305	broad.mit.edu	37	12	2968408	2968408	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr12:2968408G>A	ENST00000342628.2	-	10	1915	c.1802C>T	c.(1801-1803)tCa>tTa	p.S601L	ITFG2_ENST00000545509.1_Intron|FOXM1_ENST00000359843.3_Missense_Mutation_p.S563L|FOXM1_ENST00000361953.3_Missense_Mutation_p.S548L	NM_202002.2	NP_973731.1	Q08050	FOXM1_HUMAN	forkhead box M1	563					cell cycle|embryo development|liver development|negative regulation of cell aging|negative regulation of stress-activated MAPK cascade|negative regulation of transcription from RNA polymerase II promoter|pattern specification process|positive regulation of cell proliferation|positive regulation of transcription from RNA polymerase II promoter|regulation of cell cycle arrest|regulation of cell growth|regulation of cell proliferation|regulation of oxygen and reactive oxygen species metabolic process|regulation of Ras protein signal transduction|regulation of reactive oxygen species metabolic process|regulation of sequence-specific DNA binding transcription factor activity|tissue development|transcription from RNA polymerase II promoter|vasculogenesis	cytoplasm|transcription factor complex	DNA bending activity|DNA binding|double-stranded DNA binding|promoter binding|protein binding|protein domain specific binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|transcription factor binding			breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(7)|lung(9)|prostate(1)|skin(1)|urinary_tract(3)	24			OV - Ovarian serous cystadenocarcinoma(31;0.000622)			GGGCCCCTCTGAGAAGAGCAG	0.612000													20	30					0	0	0.043863	0	0
HEATR1	55127	broad.mit.edu	37	1	236718636	236718636	+	Silent	SNP	A	A	G			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr1:236718636A>G	ENST00000366582.3	-	41	5997	c.5883T>C	c.(5881-5883)ccT>ccC	p.P1961P	HEATR1_ENST00000366581.2_Silent_p.P1880P	NM_018072.5	NP_060542.4	Q9H583	HEAT1_HUMAN	HEAT repeat containing 1	1961					rRNA processing	nucleolus|ribonucleoprotein complex	protein binding			NS(2)|breast(7)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(18)|lung(28)|ovary(3)|prostate(1)|skin(4)|stomach(3)|upper_aerodigestive_tract(3)	87	Ovarian(103;0.0634)|Breast(184;0.133)	all_cancers(173;0.0255)|Prostate(94;0.175)	OV - Ovarian serous cystadenocarcinoma(106;0.00117)			TGTCAGCAAAAGGCTTCACTA	0.483000													3	122					0	0	0.115264	0	0
HBP1	26959	broad.mit.edu	37	7	106826251	106826251	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr7:106826251C>G	ENST00000222574.4	+	4	590	c.404C>G	c.(403-405)tCt>tGt	p.S135C	HBP1_ENST00000485846.1_Missense_Mutation_p.S135C|HBP1_ENST00000468410.1_Missense_Mutation_p.S135C	NM_012257.3	NP_036389.2	O60381	HBP1_HUMAN	HMG-box transcription factor 1	135					cell cycle arrest|regulation of transcription, DNA-dependent|transcription, DNA-dependent|Wnt receptor signaling pathway	nucleus	DNA binding			large_intestine(4)|lung(3)|prostate(1)|skin(2)	10						TTTAGATCATCTCCTGTACAC	0.393000													54	85					0	0	0.139131	0	0
FBXW7	55294	broad.mit.edu	37	4	153249401	153249401	+	Silent	SNP	C	C	T			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr4:153249401C>T	ENST00000281708.4	-	9	2606	c.1377G>A	c.(1375-1377)ggG>ggA	p.G459G	FBXW7_ENST00000603548.1_Silent_p.G459G|FBXW7_ENST00000263981.5_Silent_p.G379G|FBXW7_ENST00000603841.1_Silent_p.G459G|FBXW7_ENST00000296555.5_Silent_p.G341G|FBXW7_ENST00000393956.3_Silent_p.G283G	NM_033632.3	NP_361014.1	Q969H0	FBXW7_HUMAN	F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase	459					interspecies interaction between organisms|lipid homeostasis|negative regulation of DNA endoreduplication|negative regulation of hepatocyte proliferation|negative regulation of Notch signaling pathway|negative regulation of triglyceride biosynthetic process|positive regulation of epidermal growth factor receptor activity|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein stabilization|protein ubiquitination|regulation of lipid storage|regulation of protein localization|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|sister chromatid cohesion|vasculature development	nucleolus|nucleoplasm|SCF ubiquitin ligase complex	protein binding	p.?(1)		NS(1)|biliary_tract(8)|bone(1)|breast(5)|central_nervous_system(6)|cervix(2)|endometrium(36)|haematopoietic_and_lymphoid_tissue(159)|kidney(6)|large_intestine(155)|lung(31)|ovary(10)|pancreas(3)|prostate(2)|skin(6)|stomach(16)|upper_aerodigestive_tract(9)|urinary_tract(6)	462	all_hematologic(180;0.093)	Acute lymphoblastic leukemia(8;0.000629)|all_hematologic(8;0.067)				TGGAAGTATGCCCATATAAGG	0.413000			"""Mis, N, D, F"""		"""colorectal, endometrial, T-ALL"""								4	184					0	0	0.150653	0	0
DCP1B	196513	broad.mit.edu	37	12	2062350	2062350	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr12:2062350C>G	ENST00000280665.6	-	7	835	c.756G>C	c.(754-756)caG>caC	p.Q252H	DCP1B_ENST00000397173.4_Missense_Mutation_p.Q150H|DCP1B_ENST00000541700.1_5'UTR|DCP1B_ENST00000540622.1_Missense_Mutation_p.Q126H	NM_152640.3	NP_689853.3	Q8IZD4	DCP1B_HUMAN	decapping mRNA 1B	252	Poly-Gln.				exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	cytosol|nucleus	hydrolase activity|protein binding	p.Q252H(8)		NS(1)|breast(1)|endometrium(6)|kidney(2)|large_intestine(3)|lung(10)|skin(1)	24			OV - Ovarian serous cystadenocarcinoma(31;0.00193)			gctgctgctgctgGTGGAGAG	0.552000													3	95					0	0	0.115264	0	0
IL12RB2	3595	broad.mit.edu	37	1	67787297	67787297	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr1:67787297G>C	ENST00000262345.1	+	3	729	c.89G>C	c.(88-90)aGa>aCa	p.R30T	IL12RB2_ENST00000544434.1_Missense_Mutation_p.R30T|IL12RB2_ENST00000371000.1_Missense_Mutation_p.R30T|IL12RB2_ENST00000541374.1_Missense_Mutation_p.R30T	NM_001559.2	NP_001550.1	Q99665	I12R2_HUMAN	interleukin 12 receptor, beta 2	30					positive regulation of cell proliferation|positive regulation of interferon-gamma production	integral to plasma membrane	cytokine receptor activity			breast(3)|central_nervous_system(1)|endometrium(3)|large_intestine(8)|lung(21)|ovary(3)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	45						GCGTGCAAGAGAGGCGATGTG	0.393000													33	66					0	0	0.173368	0	0
LCTL	197021	broad.mit.edu	37	15	66855887	66855887	+	Silent	SNP	G	G	A			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr15:66855887G>A	ENST00000341509.5	-	4	578	c.447C>T	c.(445-447)ccC>ccT	p.P149P	LCTL_ENST00000537670.1_5'UTR	NM_207338.2	NP_997221.2	Q6UWM7	LCTL_HUMAN	lactase-like	149					carbohydrate metabolic process	endoplasmic reticulum membrane|integral to membrane	cation binding|hydrolase activity, hydrolyzing O-glycosyl compounds			NS(1)|breast(1)|endometrium(4)|kidney(1)|large_intestine(6)|lung(10)|ovary(2)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	32						AGGTCACGATGGGAGTGATGT	0.527000													20	34					0	0	0.076483	0	0
KIAA1407	57577	broad.mit.edu	37	3	113684007	113684007	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr3:113684007C>T	ENST00000295878.3	-	17	2952	c.2806G>A	c.(2806-2808)Gaa>Aaa	p.E936K		NM_020817.1	NP_065868.1	Q8NCU4	K1407_HUMAN	KIAA1407	936										endometrium(9)|large_intestine(7)|lung(19)|ovary(2)|pancreas(1)|prostate(1)|urinary_tract(1)	40						CTGGCTCATTCGTTCACCAGA	0.438000													20	111					0	0	0.076483	0	0
RRP15	51018	broad.mit.edu	37	1	218475717	218475717	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr1:218475717G>T	ENST00000366932.3	+	2	251	c.221G>T	c.(220-222)tGt>tTt	p.C74F	RRP15_ENST00000491428.1_3'UTR	NM_016052.3	NP_057136.2	Q9Y3B9	RRP15_HUMAN	ribosomal RNA processing 15 homolog (S. cerevisiae)	74						mitochondrion|nucleolus	protein binding		ACBD6/RRP15(2)	NS(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(7)|ovary(1)|upper_aerodigestive_tract(1)	14				all cancers(67;0.0315)|OV - Ovarian serous cystadenocarcinoma(81;0.0411)|GBM - Glioblastoma multiforme(131;0.06)|Epithelial(68;0.248)		GCTGAGCCCTGTGACAAAGAA	0.428000													23	30					1.64293e-13	1.76615e-13	0.083992	1	0
DDX60L	91351	broad.mit.edu	37	4	169383027	169383027	+	Silent	SNP	C	C	T			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr4:169383027C>T	ENST00000511577.1	-	5	676	c.429G>A	c.(427-429)ctG>ctA	p.L143L	DDX60L_ENST00000505890.1_Silent_p.L143L|DDX60L_ENST00000260184.7_Silent_p.L143L			Q5H9U9	DDX6L_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like	143							ATP binding|ATP-dependent helicase activity|RNA binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(7)|lung(23)|ovary(2)|prostate(1)|skin(1)|stomach(1)	43		Prostate(90;0.00876)|Renal(120;0.0183)|all_neural(102;0.0837)|Melanoma(52;0.132)		GBM - Glioblastoma multiforme(119;0.175)		CTGAAACTATCAGAAAATACG	0.378000													4	13					0	0	0.021553	0	0
TMEM222	84065	broad.mit.edu	37	1	27657224	27657224	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr1:27657224A>G	ENST00000374076.4	+	2	246	c.208A>G	c.(208-210)Atc>Gtc	p.I70V		NM_032125.2	NP_115501.2	Q9H0R3	TM222_HUMAN	transmembrane protein 222	70						integral to membrane	protein binding	p.I70V(1)		biliary_tract(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(2)|prostate(1)	7						GTTTTTCCCCATCATCGGCCA	0.582000													74	148					0	0	0.139131	0	0
PRPF8	10594	broad.mit.edu	37	17	1582626	1582626	+	Silent	SNP	C	C	T			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr17:1582626C>T	ENST00000572621.1	-	9	1633	c.1368G>A	c.(1366-1368)ctG>ctA	p.L456L	PRPF8_ENST00000304992.6_Silent_p.L456L			Q6P2Q9	PRP8_HUMAN	pre-mRNA processing factor 8	456						catalytic step 2 spliceosome|nuclear speck|U5 snRNP	protein binding|RNA binding			NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(13)|lung(24)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(5)|urinary_tract(3)	77				UCEC - Uterine corpus endometrioid carcinoma (25;0.0855)		TCAGGGCATTCAGCACATAGT	0.542000													38	66					0	0	0.080422	0	0
LOC220729	220729	broad.mit.edu	37	3	197346715	197346715	+	RNA	SNP	C	C	T			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr3:197346715C>T	ENST00000418868.1	-	0	729					NR_003266.2																						TCAGGAGATCCAAGGCAAAAT	0.423000													5	38					0	0	0.014758	0	0
C15orf52	388115	broad.mit.edu	37	15	40627456	40627456	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr15:40627456G>C	ENST00000397536.2	-	7	913	c.878C>G	c.(877-879)cCg>cGg	p.P293R	C15orf52_ENST00000559313.1_Missense_Mutation_p.P503R			Q6ZUT6	CO052_HUMAN	chromosome 15 open reading frame 52	503										central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(9)|urinary_tract(1)	19		all_cancers(109;9.35e-19)|all_epithelial(112;1.18e-15)|Lung NSC(122;2.45e-11)|all_lung(180;6.47e-10)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;9.06e-06)|Colorectal(105;0.0107)|BRCA - Breast invasive adenocarcinoma(123;0.0505)|READ - Rectum adenocarcinoma(2;0.0649)|Lung(196;0.0781)|LUAD - Lung adenocarcinoma(183;0.0841)		CCGGCTTCTCGGGGCCAGGCC	0.667000													5	127					0	0	0.014758	0	0
MAEA	10296	broad.mit.edu	37	4	1326563	1326563	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr4:1326563C>A	ENST00000303400.4	+	6	738	c.675C>A	c.(673-675)ttC>ttA	p.F225L	MAEA_ENST00000510794.1_Missense_Mutation_p.F224L|MAEA_ENST00000505839.1_Missense_Mutation_p.F177L|MAEA_ENST00000264750.6_Missense_Mutation_p.F184L|MAEA_ENST00000452175.2_Missense_Mutation_p.F146L|MAEA_ENST00000505177.2_Missense_Mutation_p.F263L|MAEA_ENST00000514708.1_Missense_Mutation_p.Q159K|MAEA_ENST00000512289.1_3'UTR	NM_001017405.1	NP_001017405.1	Q7L5Y9	MAEA_HUMAN	macrophage erythroblast attacher	225					cell adhesion|cell cycle|cell division|erythrocyte maturation|negative regulation of myeloid cell apoptosis|regulation of mitotic cell cycle	actomyosin contractile ring|integral to plasma membrane|membrane fraction|nuclear matrix|spindle	actin binding			NS(2)|central_nervous_system(1)|endometrium(2)|large_intestine(5)|lung(2)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	18			OV - Ovarian serous cystadenocarcinoma(23;0.0201)			GAAAGCACTTCAGCCAAGCAG	0.517000													10	26					3.07112e-06	3.16307e-06	0.080935	1	0
ANO2	57101	broad.mit.edu	37	12	6031929	6031929	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr12:6031929G>A	ENST00000546188.1	-	2	123	c.52C>T	c.(52-54)Cag>Tag	p.Q18*	ANO2_ENST00000327087.8_Nonsense_Mutation_p.Q18*|ANO2_ENST00000356134.5_Nonsense_Mutation_p.Q18*			Q9NQ90	ANO2_HUMAN	anoctamin 2	22						chloride channel complex|plasma membrane	intracellular calcium activated chloride channel activity			central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(11)|lung(23)|ovary(4)|pancreas(1)|prostate(1)|skin(5)|stomach(3)|upper_aerodigestive_tract(1)	58						GACCCTGCCTGAGGGCTCAGC	0.622000													10	18					0	0	0.093190	0	0
AFF1	4299	broad.mit.edu	37	4	88047256	88047256	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr4:88047256C>T	ENST00000307808.6	+	13	2978	c.2558C>T	c.(2557-2559)tCc>tTc	p.S853F	AFF1_ENST00000544085.1_Missense_Mutation_p.S491F|AFF1_ENST00000395146.4_Missense_Mutation_p.S860F	NM_005935.2	NP_005926.1	P51825	AFF1_HUMAN	AF4/FMR2 family, member 1	853						nucleus	sequence-specific DNA binding transcription factor activity			breast(1)|large_intestine(2)	3		Acute lymphoblastic leukemia(40;0.0935)|all_hematologic(202;0.111)|Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000233)		TCCAGGCCCTCCAGGCCCTCC	0.537000													50	69					0	0	0.139131	0	0
GSTK1	373156	broad.mit.edu	37	7	142965251	142965251	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr7:142965251G>A	ENST00000479303.1	+	6	831	c.773G>A	c.(772-774)cGg>cAg	p.R258Q	GSTK1_ENST00000409500.3_Missense_Mutation_p.R190Q|GSTK1_ENST00000358406.5_Missense_Mutation_p.R202Q|GSTK1_ENST00000443571.2_Missense_Mutation_p.R159Q|AC073342.12_ENST00000427392.1_RNA	NM_001143679.1	NP_001137151.1	Q9Y2Q3	GSTK1_HUMAN	glutathione S-transferase kappa 1	202						outer membrane-bounded periplasmic space|peroxisome	glutathione transferase activity|identical protein binding|protein disulfide oxidoreductase activity			lung(4)	4	Melanoma(164;0.059)				Glutathione(DB00143)	GGCTCTGACCGGATGGAGCTG	0.552000													5	325					0	0	0.014758	0	0
SETD5	55209	broad.mit.edu	37	3	9476528	9476528	+	Missense_Mutation	SNP	T	T	G			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr3:9476528T>G	ENST00000402466.1	+	6	785	c.17T>G	c.(16-18)gTt>gGt	p.V6G	SETD5_ENST00000407969.1_Missense_Mutation_p.V136G|SETD5_ENST00000302463.6_Missense_Mutation_p.V6G|SETD5_ENST00000406341.1_Missense_Mutation_p.V117G|SETD5_ENST00000402198.1_Missense_Mutation_p.V117G			Q9C0A6	SETD5_HUMAN	SET domain containing 5	117										NS(2)|breast(3)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(10)|lung(11)|ovary(3)|prostate(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	47	Medulloblastoma(99;0.227)			OV - Ovarian serous cystadenocarcinoma(96;0.112)		AGGGGGAAGGTTATTAGACTT	0.438000													9	31					0	0	0.093190	0	0
NHLRC1	378884	broad.mit.edu	37	6	18122141	18122141	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr6:18122141C>G	ENST00000340650.3	-	1	710	c.697G>C	c.(697-699)Gat>Cat	p.D233H		NM_198586.2	NP_940988.2	Q6VVB1	NHLC1_HUMAN	NHL repeat containing 1	233			D -> A (in EPM2).		proteasomal ubiquitin-dependent protein catabolic process|protein polyubiquitination	endoplasmic reticulum|nucleus	protein binding|ubiquitin-protein ligase activity|zinc ion binding			breast(1)|kidney(1)|large_intestine(3)|lung(3)|skin(1)|urinary_tract(2)	11	Ovarian(93;0.016)|Breast(50;0.0245)	all_hematologic(90;0.165)	all cancers(50;0.0451)|Epithelial(50;0.0493)			GCCTCCGCATCAGTTACCACA	0.542000													12	38					0	0	0.132662	0	0
PLEC	5339	broad.mit.edu	37	8	144992204	144992204	+	Silent	SNP	G	G	A			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr8:144992204G>A	ENST00000322810.4	-	32	12365	c.12196C>T	c.(12196-12198)Ctg>Ttg	p.L4066L	PLEC_ENST00000527096.1_Silent_p.L3952L|PLEC_ENST00000354958.2_Silent_p.L3907L|PLEC_ENST00000436759.2_Silent_p.L3956L|PLEC_ENST00000357649.2_Silent_p.L3933L|PLEC_ENST00000345136.3_Silent_p.L3929L|PLEC_ENST00000354589.3_Silent_p.L3929L|PLEC_ENST00000398774.2_Silent_p.L3897L|PLEC_ENST00000356346.3_Silent_p.L3915L	NM_201380.2	NP_958782.1	Q15149	PLEC_HUMAN	plectin	4066	Globular 2.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle			NS(1)|breast(3)|central_nervous_system(4)|cervix(7)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(8)|lung(57)|ovary(4)|pancreas(2)|prostate(11)|skin(9)|stomach(2)|upper_aerodigestive_tract(10)	137						GTGCCTTCCAGGAACTTCTGC	0.642000													7	8					0	0	0.038147	0	0
DMXL1	1657	broad.mit.edu	37	5	118533530	118533530	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr5:118533530G>A	ENST00000311085.8	+	32	7704	c.7624G>A	c.(7624-7626)Gaa>Aaa	p.E2542K	DMXL1_ENST00000539542.1_Missense_Mutation_p.E2542K	NM_005509.4	NP_005500.4	Q9Y485	DMXL1_HUMAN	Dmx-like 1	2542										breast(3)|central_nervous_system(1)|endometrium(14)|kidney(4)|large_intestine(20)|liver(6)|lung(28)|ovary(2)|prostate(5)|skin(2)|upper_aerodigestive_tract(1)	86		all_cancers(142;0.0314)|all_epithelial(76;0.00559)|Prostate(80;0.11)|Breast(839;0.231)		OV - Ovarian serous cystadenocarcinoma(64;0.000563)|Epithelial(69;0.00179)|all cancers(49;0.0243)		CCGACGACTTGAAATCCATGG	0.443000													73	73					0	0	0.139131	0	0
FRAS1	80144	broad.mit.edu	37	4	79403092	79403092	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr4:79403092G>A	ENST00000264895.6	+	57	9018	c.8578G>A	c.(8578-8580)Gaa>Aaa	p.E2860K		NM_025074.6	NP_079350.5	Q86XX4	FRAS1_HUMAN	Fraser syndrome 1	2855	Calx-beta 3.				cell communication	integral to membrane|plasma membrane	metal ion binding			breast(2)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(5)|lung(54)|prostate(7)|skin(2)|urinary_tract(4)	103						TCGGAAGGTGGAATTTGGGCC	0.522000													49	43					0	0	0.139131	0	0
TPR	7175	broad.mit.edu	37	1	186327736	186327736	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr1:186327736G>A	ENST00000367478.3	-	13	1732	c.1436C>T	c.(1435-1437)tCa>tTa	p.S479L	TPR_ENST00000474852.1_5'UTR	NM_003292.2	NP_003283.2	P12270	TPR_HUMAN	translocated promoter region, nuclear basket protein	479					carbohydrate metabolic process|glucose transport|mitotic cell cycle spindle assembly checkpoint|mRNA transport|protein import into nucleus|regulation of glucose transport|seryl-tRNA aminoacylation|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytoplasm|nuclear membrane|nuclear pore|nucleoplasm	ATP binding|protein binding|serine-tRNA ligase activity	p.S480*(1)		autonomic_ganglia(1)|breast(5)|central_nervous_system(4)|cervix(2)|endometrium(9)|kidney(12)|large_intestine(23)|liver(1)|lung(45)|ovary(2)|pancreas(1)|prostate(6)|skin(3)|stomach(1)|urinary_tract(8)	123		Breast(1374;0.000659)|Lung SC(1967;0.0262)|Prostate(1639;0.157)		Colorectal(1306;1.12e-05)|KIRC - Kidney renal clear cell carcinoma(1967;0.00553)		AAGTACAGATGATTGCTTGTT	0.318000			T	NTRK1	papillary thyroid								28	75					0	0	0.163468	0	0
SLC35G3	146861	broad.mit.edu	37	17	33520358	33520358	+	Silent	SNP	A	A	G	rs74740601	by1000genomes	TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr17:33520358A>G	ENST00000297307.5	-	1	1054	c.969T>C	c.(967-969)atT>atC	p.I323I		NM_152462.2	NP_689675.1	Q8N808	AMAC1_HUMAN	solute carrier family 35, member G3	323	DUF6 2.					integral to membrane		p.I323I(1)									TCTGGGCTGTAATGATGGCAA	0.547000													6	82					0	0	0.029380	0	0
C20orf112	140688	broad.mit.edu	37	20	31062481	31062481	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr20:31062481G>A	ENST00000359676.5	-	2	174	c.32C>T	c.(31-33)cCg>cTg	p.P11L	C20orf112_ENST00000375678.3_Missense_Mutation_p.P120L|C20orf112_ENST00000326071.4_Missense_Mutation_p.P11L|C20orf112_ENST00000375677.1_Missense_Mutation_p.P33L|C20orf112_ENST00000475781.1_5'UTR	NM_001256798.1|NM_080616.4	NP_001243727.1|NP_542183.2	Q96MY1	CT112_HUMAN	chromosome 20 open reading frame 112	11										endometrium(3)|kidney(2)|large_intestine(5)|lung(5)	15						GGCCAGGTGCGGGTCAGCTGA	0.597000													12	23					0	0	0.093190	0	0
CTSS	1520	broad.mit.edu	37	1	150724480	150724480	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr1:150724480G>T	ENST00000368985.3	-	5	664	c.404C>A	c.(403-405)tCt>tAt	p.S135Y	CTSS_ENST00000480760.1_5'UTR|CTSS_ENST00000448301.2_Missense_Mutation_p.S85Y	NM_001199739.1|NM_004079.4	NP_001186668.1|NP_004070.3	P25774	CATS_HUMAN	cathepsin S	135					immune response|proteolysis	extracellular region|lysosome	cysteine-type endopeptidase activity			cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(5)|skin(1)|stomach(1)|urinary_tract(1)	15	all_cancers(9;6.17e-52)|all_epithelial(9;9.7e-43)|all_lung(15;5.74e-35)|Lung NSC(24;2.09e-31)|Breast(34;0.00146)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Melanoma(130;0.128)|Colorectal(459;0.171)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0485)|Epithelial(6;5.02e-21)|all cancers(9;1.28e-20)|OV - Ovarian serous cystadenocarcinoma(6;1.09e-14)|BRCA - Breast invasive adenocarcinoma(12;0.00501)|LUSC - Lung squamous cell carcinoma(543;0.171)			AGCACCACAAGAACCCTAAAA	0.493000													15	28					6.31663e-08	6.6654e-08	0.132662	1	0
RASAL2	9462	broad.mit.edu	37	1	178433454	178433454	+	Silent	SNP	G	G	A			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr1:178433454G>A	ENST00000448150.3	+	15	4079	c.3261G>A	c.(3259-3261)gaG>gaA	p.E1087E	RASAL2_ENST00000462775.1_Silent_p.E957E|RASAL2_ENST00000367649.3_Silent_p.E1098E	NM_170692.2	NP_733793.2	Q9UJF2	NGAP_HUMAN	RAS protein activator like 2	957					negative regulation of Ras protein signal transduction|signal transduction	cytoplasm|intrinsic to internal side of plasma membrane	Ras GTPase activator activity			biliary_tract(1)|breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|liver(2)|lung(25)|ovary(2)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	54						CCCCAGTAGAGAGGACAGCAG	0.478000													15	23					0	0	0.119110	0	0
CORO6	84940	broad.mit.edu	37	17	27943185	27943185	+	Silent	SNP	G	G	A			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr17:27943185G>A	ENST00000345068.5	-	10	1284	c.1071C>T	c.(1069-1071)ctC>ctT	p.L357L	RP11-68I3.2_ENST00000581474.1_RNA|CORO6_ENST00000445145.2_Silent_p.L357L|CORO6_ENST00000577909.1_5'UTR|CORO6_ENST00000584969.1_Silent_p.L357L|CORO6_ENST00000580212.1_Silent_p.L317L|CORO6_ENST00000456796.3_Silent_p.L123L|CORO6_ENST00000388767.3_Silent_p.L357L			Q6QEF8	CORO6_HUMAN	coronin 6	357					actin cytoskeleton organization	actin cytoskeleton	actin filament binding			breast(1)|cervix(1)|endometrium(1)|large_intestine(4)|lung(4)|prostate(1)|urinary_tract(2)	14						CGTCCTGGAAGAGGTCTGACT	0.667000													8	13					0	0	0.038147	0	0
DDX60L	91351	broad.mit.edu	37	4	169383170	169383170	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr4:169383170C>T	ENST00000511577.1	-	5	533	c.286G>A	c.(286-288)Gat>Aat	p.D96N	DDX60L_ENST00000505890.1_Missense_Mutation_p.D96N|DDX60L_ENST00000260184.7_Missense_Mutation_p.D96N			Q5H9U9	DDX6L_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like	96							ATP binding|ATP-dependent helicase activity|RNA binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(7)|lung(23)|ovary(2)|prostate(1)|skin(1)|stomach(1)	43		Prostate(90;0.00876)|Renal(120;0.0183)|all_neural(102;0.0837)|Melanoma(52;0.132)		GBM - Glioblastoma multiforme(119;0.175)		TCAGGAAAATCAAAATATGCA	0.348000													7	10					0	0	0.029380	0	0
LRRC3	81543	broad.mit.edu	37	21	45876816	45876816	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr21:45876816C>T	ENST00000291592.4	+	2	606	c.289C>T	c.(289-291)Cac>Tac	p.H97Y		NM_030891.3	NP_112153.1	Q9BY71	LRRC3_HUMAN	leucine rich repeat containing 3	97						integral to membrane	protein binding			endometrium(2)|kidney(1)|lung(1)|urinary_tract(1)	5		Breast(209;0.00908)		COAD - Colon adenocarcinoma(84;0.148)|Lung(125;0.195)		GGATCTGTCTCACAACGCCAT	0.662000													23	46					0	0	0.083992	0	0
GPRC5C	55890	broad.mit.edu	37	17	72436363	72436363	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr17:72436363G>A	ENST00000392627.1	+	2	1709	c.583G>A	c.(583-585)Ggg>Agg	p.G195R	GPRC5C_ENST00000392629.2_Missense_Mutation_p.G162R|GPRC5C_ENST00000342648.5_Intron|GPRC5C_ENST00000481232.1_Intron	NM_022036.2	NP_071319.2	Q9NQ84	GPC5C_HUMAN	G protein-coupled receptor, family C, group 5, member C	150						cytoplasmic vesicle membrane|integral to plasma membrane	G-protein coupled receptor activity|protein binding			central_nervous_system(1)|large_intestine(3)|lung(9)|ovary(2)|pancreas(1)|prostate(1)	17						GAAGAACCACGGGCCCCGGGG	0.597000													4	101					0	0	0.150653	0	0
ANK3	288	broad.mit.edu	37	10	61829440	61829440	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr10:61829440C>T	ENST00000280772.1	-	37	11390	c.11199G>A	c.(11197-11199)atG>atA	p.M3733I	ANK3_ENST00000355288.2_Intron|ANK3_ENST00000503366.1_Intron|ANK3_ENST00000373827.2_Intron	NM_020987.3	NP_066267.2	Q12955	ANK3_HUMAN	ankyrin 3, node of Ranvier (ankyrin G)	3733					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						CTTCTTTCTTCATGGTCATGG	0.428000													106	151					0	0	0.139131	0	0
B2M	567	broad.mit.edu	37	15	45003747	45003747	+	Translation_Start_Site	SNP	G	G	T			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr15:45003747G>T	ENST00000558401.1	+	1	73	c.3G>T	c.(1-3)atG>atT	p.M1I	B2M_ENST00000544417.1_Start_Codon_SNP_p.M1I|B2M_ENST00000559916.1_Start_Codon_SNP_p.M1I	NM_004048.2	NP_004039.1	P61769	B2MG_HUMAN	beta-2-microglobulin	1					antigen processing and presentation of peptide antigen via MHC class I|interferon-gamma-mediated signaling pathway|regulation of defense response to virus by virus|viral reproduction	early endosome membrane|Golgi membrane|MHC class I protein complex	protein binding	p.M1I(1)|p.?(1)		breast(2)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(30)|kidney(8)|large_intestine(6)|lung(6)|ovary(2)|skin(2)|urinary_tract(1)	59		all_cancers(109;1.88e-13)|all_epithelial(112;2.13e-11)|Lung NSC(122;2.22e-07)|all_lung(180;1.81e-06)|Melanoma(134;0.0122)		all cancers(107;4.16e-21)|GBM - Glioblastoma multiforme(94;8.97e-07)|COAD - Colon adenocarcinoma(120;0.0357)|Colorectal(105;0.0377)|Lung(196;0.0903)|LUSC - Lung squamous cell carcinoma(244;0.192)		GGGCCGAGATGTCTCGCTCCG	0.612000													20	17					1.96895e-08	2.09049e-08	0.076483	1	0
COL5A1	1289	broad.mit.edu	37	9	137734077	137734077	+	Silent	SNP	C	C	T			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr9:137734077C>T	ENST00000371817.3	+	66	5859	c.5445C>T	c.(5443-5445)atC>atT	p.I1815I		NM_000093.3|NM_001278074.1	NP_000084.3|NP_001265003.1	P20908	CO5A1_HUMAN	collagen, type V, alpha 1	1815	Fibrillar collagen NC1.				axon guidance|cell adhesion|collagen biosynthetic process|collagen fibril organization|eye morphogenesis|fibril organization|integrin biosynthetic process|skin development|wound healing, spreading of epidermal cells	collagen type V	heparin binding|integrin binding|platelet-derived growth factor binding|proteoglycan binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(26)|liver(2)|lung(36)|ovary(4)|pancreas(4)|prostate(5)|skin(10)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(4)	115		Myeloproliferative disorder(178;0.0341)		all cancers(34;2.28e-08)|OV - Ovarian serous cystadenocarcinoma(145;6.03e-08)|Epithelial(140;6.4e-08)|GBM - Glioblastoma multiforme(294;0.131)		TCGTGGACATCATGTTCAATG	0.582000													14	25					0	0	0.119110	0	0
ANK3	288	broad.mit.edu	37	10	61830234	61830234	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr10:61830234C>T	ENST00000280772.1	-	37	10596	c.10405G>A	c.(10405-10407)Gag>Aag	p.E3469K	ANK3_ENST00000355288.2_Intron|ANK3_ENST00000503366.1_Intron|ANK3_ENST00000373827.2_Intron	NM_020987.3	NP_066267.2	Q12955	ANK3_HUMAN	ankyrin 3, node of Ranvier (ankyrin G)	3469					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						TTTCCCTCCTCCTCGATAACT	0.448000													28	51					0	0	0.125774	0	0
C10orf76	79591	broad.mit.edu	37	10	103799781	103799781	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr10:103799781C>G	ENST00000370033.4	-	2	210	c.91G>C	c.(91-93)Gag>Cag	p.E31Q	C10orf76_ENST00000311122.5_Missense_Mutation_p.E31Q	NM_024541.2	NP_078817.2	Q5T2E6	CJ076_HUMAN	chromosome 10 open reading frame 76	31						integral to membrane				autonomic_ganglia(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(7)|prostate(2)|upper_aerodigestive_tract(2)	24		Colorectal(252;0.123)		Epithelial(162;2.41e-08)|all cancers(201;6.41e-07)		ATGAAGATCTCATCATACATC	0.458000													67	129					0	0	0.139131	0	0
POLD3	10714	broad.mit.edu	37	11	74340350	74340350	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr11:74340350G>C	ENST00000263681.2	+	9	1117	c.988G>C	c.(988-990)Gat>Cat	p.D330H	POLD3_ENST00000532497.1_Missense_Mutation_p.D224H|POLD3_ENST00000527458.1_Missense_Mutation_p.D291H	NM_006591.2	NP_006582.1	Q15054	DPOD3_HUMAN	polymerase (DNA-directed), delta 3, accessory subunit	330					base-excision repair|DNA strand elongation involved in DNA replication|DNA synthesis involved in DNA repair|mismatch repair|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	delta DNA polymerase complex|nucleoplasm	DNA-directed DNA polymerase activity|protein binding			breast(2)|endometrium(2)|kidney(2)|large_intestine(3)|lung(6)|ovary(1)|skin(1)|stomach(1)	18	Breast(11;3.21e-06)					TCCTGAATCTGATAGCAGTGA	0.398000													40	41					0	0	0.086207	0	0
AFF1	4299	broad.mit.edu	37	4	88047277	88047277	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr4:88047277C>T	ENST00000307808.6	+	13	2999	c.2579C>T	c.(2578-2580)tCa>tTa	p.S860L	AFF1_ENST00000544085.1_Missense_Mutation_p.S498L|AFF1_ENST00000395146.4_Missense_Mutation_p.S867L	NM_005935.2	NP_005926.1	P51825	AFF1_HUMAN	AF4/FMR2 family, member 1	860						nucleus	sequence-specific DNA binding transcription factor activity			breast(1)|large_intestine(2)	3		Acute lymphoblastic leukemia(40;0.0935)|all_hematologic(202;0.111)|Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000233)		TCACAGTCCTCAAAGAAGGAA	0.552000													41	59					0	0	0.086207	0	0
COX17	10063	broad.mit.edu	37	3	119396148	119396148	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr3:119396148G>C	ENST00000261070.2	-	1	102	c.10C>G	c.(10-12)Ctg>Gtg	p.L4V	COX17_ENST00000497116.1_Missense_Mutation_p.L4V|COX17_ENST00000484810.1_Missense_Mutation_p.L4V	NM_005694.1	NP_005685.1	Q14061	COX17_HUMAN	COX17 cytochrome c oxidase copper chaperone	4	Ala/Pro-rich.				copper ion transport|generation of precursor metabolites and energy	mitochondrial intermembrane space	copper chaperone activity			central_nervous_system(1)|kidney(1)|large_intestine(1)	3				GBM - Glioblastoma multiforme(114;0.227)		GAGTCAACCAGACCCGGCATC	0.617000													6	21					0	0	0.038147	0	0
MPP1	4354	broad.mit.edu	37	X	154033630	154033630	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chrX:154033630C>T	ENST00000369534.3	-	1	166	c.19G>A	c.(19-21)Gag>Aag	p.E7K	MPP1_ENST00000413259.3_5'UTR|MPP1_ENST00000393531.1_Missense_Mutation_p.E7K	NM_001166460.1|NM_001166461.1|NM_002436.3	NP_001159932.1|NP_001159933.1|NP_002427.1	Q00013	EM55_HUMAN	membrane protein, palmitoylated 1, 55kDa	7					regulation of neutrophil chemotaxis|signal transduction	integral to plasma membrane|membrane fraction|stereocilium	guanylate kinase activity|protein binding			central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(4)|liver(1)|lung(9)|ovary(2)|prostate(1)	21	all_cancers(53;8.15e-17)|all_epithelial(53;1.1e-10)|all_lung(58;6.63e-07)|Lung NSC(58;2.08e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)					CTCTCGCCCTCGCTCGCCTTG	0.662000													5	2					0	0	0.014758	0	0
DNAJA1	3301	broad.mit.edu	37	9	33030454	33030454	+	Silent	SNP	A	A	G			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr9:33030454A>G	ENST00000330899.4	+	5	615	c.432A>G	c.(430-432)aaA>aaG	p.K144K	DNAJA1_ENST00000544625.1_5'UTR|DNAJA1_ENST00000495015.1_Intron	NM_001539.2	NP_001530.1	P31689	DNJA1_HUMAN	DnaJ (Hsp40) homolog, subfamily A, member 1	144					protein folding|response to heat|response to unfolded protein	membrane	ATP binding|heat shock protein binding|low-density lipoprotein particle receptor binding|metal ion binding|unfolded protein binding			large_intestine(2)|ovary(1)|skin(3)	6			LUSC - Lung squamous cell carcinoma(29;0.0227)	GBM - Glioblastoma multiforme(74;0.102)		GAGGTAAGAAAGGAGCAGTAG	0.353000													11	8					0	0	0.105934	0	0
ZNF512B	57473	broad.mit.edu	37	20	62598782	62598782	+	Silent	SNP	C	C	T			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr20:62598782C>T	ENST00000450537.1	-	3	276	c.216G>A	c.(214-216)aaG>aaA	p.K72K	ZNF512B_ENST00000369888.1_Silent_p.K72K|ZNF512B_ENST00000217130.3_Silent_p.K72K			Q96KM6	Z512B_HUMAN	zinc finger protein 512B	72					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|cervix(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(3)|lung(16)|ovary(1)|prostate(4)|skin(1)	33	all_cancers(38;2.14e-11)|all_epithelial(29;3.41e-13)|Lung NSC(23;3.41e-09)|all_lung(23;1.06e-08)					GCCCCTTTTTCTTCCCTTCTG	0.632000													58	85					0	0	0.139131	0	0
EZH1	2145	broad.mit.edu	37	17	40870631	40870631	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr17:40870631G>A	ENST00000428826.2	-	9	893	c.772C>T	c.(772-774)Cga>Tga	p.R258*	EZH1_ENST00000592743.1_Nonsense_Mutation_p.R258*|EZH1_ENST00000435174.1_Nonsense_Mutation_p.R119*|EZH1_ENST00000415827.2_Nonsense_Mutation_p.R249*|EZH1_ENST00000590078.1_Nonsense_Mutation_p.R188*|EZH1_ENST00000585893.1_Nonsense_Mutation_p.R218*			Q92800	EZH1_HUMAN	enhancer of zeste homolog 1 (Drosophila)	258					anatomical structure morphogenesis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	ESC/E(Z) complex	chromatin binding|DNA binding			breast(1)|endometrium(4)|large_intestine(6)|lung(9)|ovary(3)|prostate(1)|skin(1)|urinary_tract(2)	27		Breast(137;0.00104)		BRCA - Breast invasive adenocarcinoma(366;0.0784)		GTTAGTTCTCGATACCTATTT	0.507000													16	36					0	0	0.160694	0	0
SLC35B3	51000	broad.mit.edu	37	6	8421006	8421006	+	Silent	SNP	C	C	T			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr6:8421006C>T	ENST00000379660.4	-	6	1079	c.630G>A	c.(628-630)ctG>ctA	p.L210L	SLC35B3_ENST00000339306.5_Silent_p.L210L	NM_001142540.1|NM_001142541.1|NM_015948.3	NP_001136012.1|NP_001136013.1|NP_057032.2	Q9H1N7	S35B3_HUMAN	solute carrier family 35 (adenosine 3'-phospho 5'-phosphosulfate transporter), member B3	210					transmembrane transport	Golgi membrane|integral to membrane				breast(2)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(5)|lung(1)|prostate(1)	15	Ovarian(93;0.0569)					TAAACCATATCAGGCCAAGGC	0.388000													37	111					0	0	0.124865	0	0
ANK3	288	broad.mit.edu	37	10	61829289	61829289	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr10:61829289C>G	ENST00000280772.1	-	37	11541	c.11350G>C	c.(11350-11352)Gat>Cat	p.D3784H	ANK3_ENST00000355288.2_Intron|ANK3_ENST00000503366.1_Intron|ANK3_ENST00000373827.2_Intron	NM_020987.3	NP_066267.2	Q12955	ANK3_HUMAN	ankyrin 3, node of Ranvier (ankyrin G)	3784					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						TTAAAGTTATCTTTTTGAAAA	0.343000													64	96					0	0	0.139131	0	0
SLX4	84464	broad.mit.edu	37	16	3639417	3639417	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr16:3639417G>A	ENST00000294008.3	-	12	4862	c.4222C>T	c.(4222-4224)Cag>Tag	p.Q1408*		NM_032444.2	NP_115820.2	Q8IY92	SLX4_HUMAN	SLX4 structure-specific endonuclease subunit	1408	Interaction with MUS81.|Interaction with PLK1 and TERF2-TERF2IP.				DNA double-strand break processing involved in repair via single-strand annealing|double-strand break repair via homologous recombination|nucleotide-excision repair	Slx1-Slx4 complex	enzyme activator activity|protein binding			breast(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(18)|lung(20)|ovary(3)|pancreas(1)|prostate(7)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	76						CTGTTGGCCTGATGGGAGGCC	0.607000								Direct reversal of damage					49	62					0	0	0.139131	0	0
NRCAM	4897	broad.mit.edu	37	7	107880487	107880487	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr7:107880487T>C	ENST00000379028.3	-	4	492	c.22A>G	c.(22-24)Aaa>Gaa	p.K8E	NRCAM_ENST00000379024.4_Missense_Mutation_p.K8E|NRCAM_ENST00000413765.2_Missense_Mutation_p.K8E|NRCAM_ENST00000351718.4_Missense_Mutation_p.K8E|NRCAM_ENST00000379022.4_Missense_Mutation_p.K8E|NRCAM_ENST00000425651.2_Missense_Mutation_p.K8E			Q92823	NRCAM_HUMAN	neuronal cell adhesion molecule	8					angiogenesis|axon guidance|axonal fasciculation|cell-cell adhesion|central nervous system development|clustering of voltage-gated sodium channels|neuron migration|positive regulation of neuron differentiation|regulation of axon extension|synapse assembly	external side of plasma membrane|integral to plasma membrane	ankyrin binding			breast(4)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(8)|liver(1)|lung(36)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(4)	65						CGCTTCTTTTTCGGCATTATT	0.418000													45	69					0	0	0.139131	0	0
GRM5	2915	broad.mit.edu	37	11	88717906	88717906	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr11:88717906G>T	ENST00000393294.3	-	4	1231	c.862C>A	c.(862-864)Cct>Act	p.P288T	GRM5_ENST00000393297.1_Intron|GRM5_ENST00000455756.2_Intron|GRM5_ENST00000305432.5_Intron|GRM5_ENST00000305447.4_Intron|GRM5_ENST00000418177.2_Intron			P41594	GRM5_HUMAN	glutamate receptor, metabotropic 5	0					activation of phospholipase C activity by metabotropic glutamate receptor signaling pathway|synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			NS(1)|breast(5)|central_nervous_system(4)|endometrium(5)|kidney(3)|large_intestine(18)|lung(40)|ovary(3)|pancreas(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	90		Acute lymphoblastic leukemia(157;2.54e-05)|all_hematologic(158;0.00834)			Acamprosate(DB00659)	AAAGCTATAGGAGAAAGAAAG	0.303000													3	2					6.4e-05	6.51361e-05	0.115264	1	0
NT5C1B	93034	broad.mit.edu	37	2	18765360	18765360	+	Silent	SNP	G	G	A			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr2:18765360G>A	ENST00000304081.4	-	5	985	c.885C>T	c.(883-885)ttC>ttT	p.F295F	NT5C1B_ENST00000359846.2_Silent_p.F355F|NT5C1B_ENST00000600945.1_Silent_p.F355F|NT5C1B-RDH14_ENST00000532967.1_Silent_p.F355F	NM_033253.3	NP_150278.2			5'-nucleotidase, cytosolic IB											endometrium(2)|kidney(2)|large_intestine(10)|lung(8)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|urinary_tract(1)	29	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.177)	Ovarian(717;0.208)				ATACCTTGACGAAGCGGAACG	0.572000													29	67					0	0	0.153744	0	0
TMEM63A	9725	broad.mit.edu	37	1	226041387	226041387	+	Silent	SNP	G	G	C			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr1:226041387G>C	ENST00000366835.3	-	19	2010	c.1740C>G	c.(1738-1740)ctC>ctG	p.L580L		NM_014698.2	NP_055513.2	O94886	TM63A_HUMAN	transmembrane protein 63A	580						integral to membrane|lysosomal membrane	nucleotide binding			breast(2)|endometrium(3)|large_intestine(5)|lung(6)|ovary(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	24	Breast(184;0.197)					GGAAGGTATAGAGGATGAGAC	0.602000													5	5					0	0	0.014758	0	0
KALRN	8997	broad.mit.edu	37	3	124066089	124066089	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr3:124066089G>A	ENST00000360013.3	+	10	1868	c.1741G>A	c.(1741-1743)Gat>Aat	p.D581N	KALRN_ENST00000240874.3_Missense_Mutation_p.D581N|KALRN_ENST00000460856.1_Missense_Mutation_p.D581N	NM_001024660.3	NP_001019831.2	O60229	KALRN_HUMAN	kalirin, RhoGEF kinase	581					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|vesicle-mediated transport	actin cytoskeleton|cytosol	ATP binding|GTPase activator activity|metal ion binding|protein binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(21)|lung(28)|ovary(4)|prostate(5)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	83						GAAGAGGCATGATGACTTTGA	0.527000													26	145					0	0	0.153744	0	0
AGO4	192670	broad.mit.edu	37	1	36291577	36291577	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr1:36291577G>C	ENST00000373210.3	+	6	921	c.676G>C	c.(676-678)Gag>Cag	p.E226Q		NM_017629.3	NP_060099.2			argonaute RISC catalytic component 4																		GTTCATGTGTGAGGTTTTAGA	0.418000													60	91					0	0	0.139131	0	0
ATXN7L2	127002	broad.mit.edu	37	1	110028684	110028684	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr1:110028684G>A	ENST00000369870.3	+	2	148	c.133G>A	c.(133-135)Gag>Aag	p.E45K		NM_153340.4	NP_699171.3	Q5T6C5	AT7L2_HUMAN	ataxin 7-like 2	45										breast(2)|endometrium(1)|kidney(1)|large_intestine(4)|lung(5)|ovary(2)|prostate(1)|skin(1)	17		all_epithelial(167;0.00197)|all_lung(203;0.00291)|Lung NSC(277;0.00453)		Colorectal(144;0.0129)|Lung(183;0.0426)|Epithelial(280;0.0675)|READ - Rectum adenocarcinoma(129;0.0693)|all cancers(265;0.071)|LUSC - Lung squamous cell carcinoma(189;0.228)		TCTAGGGGCTGAGCTGGAGGA	0.527000													33	43					0	0	0.064281	0	0
CHM	1121	broad.mit.edu	37	X	85211360	85211360	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chrX:85211360C>T	ENST00000357749.2	-	8	993	c.964G>A	c.(964-966)Gaa>Aaa	p.E322K	CHM_ENST00000537751.1_Missense_Mutation_p.E174K|CHM_ENST00000467744.1_Intron	NM_000390.2	NP_000381.1	P24386	RAE1_HUMAN	choroideremia (Rab escort protein 1)	322					intracellular protein transport|protein geranylgeranylation|response to stimulus|visual perception	Rab-protein geranylgeranyltransferase complex	GTPase activator activity|Rab geranylgeranyltransferase activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|liver(1)|lung(12)|ovary(1)|prostate(1)	20		all_lung(315;5.41e-06)				TTTAAATATTCATAAAATGTG	0.333000													11	3					0	0	0.093190	0	0
LMLN	89782	broad.mit.edu	37	3	197751552	197751552	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr3:197751552G>A	ENST00000330198.4	+	14	1571	c.1549G>A	c.(1549-1551)Gaa>Aaa	p.E517K	LMLN_ENST00000482695.1_Missense_Mutation_p.E502K|LMLN_ENST00000420910.2_Missense_Mutation_p.E554K|LMLN_ENST00000332636.5_Missense_Mutation_p.E465K	NM_033029.3	NP_149018.2	Q96KR4	LMLN_HUMAN	leishmanolysin-like (metallopeptidase M8 family)	517					cell adhesion|cell division|mitosis|proteolysis	cytoplasm|membrane	metalloendopeptidase activity|zinc ion binding			endometrium(3)|kidney(2)|large_intestine(4)|lung(12)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	25	all_cancers(143;1.15e-09)|Ovarian(172;0.0418)|Breast(254;0.0976)	Lung NSC(153;0.132)	Epithelial(36;9.84e-24)|all cancers(36;3.18e-22)|OV - Ovarian serous cystadenocarcinoma(49;5.35e-19)|LUSC - Lung squamous cell carcinoma(58;6.94e-07)|Lung(62;9.92e-07)	GBM - Glioblastoma multiforme(93;0.111)		CTATGGCGCTGAAAAGTATGG	0.393000													21	92					0	0	0.055883	0	0
CRELD2	79174	broad.mit.edu	37	22	50319135	50319135	+	Silent	SNP	G	G	A	rs151259822		TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr22:50319135G>A	ENST00000404488.3	+	10	1221	c.1086G>A	c.(1084-1086)ggG>ggA	p.G362G	CRELD2_ENST00000403427.3_Silent_p.G285G|CRELD2_ENST00000407217.3_Silent_p.G281G|CRELD2_ENST00000328268.4_Silent_p.G313G	NM_001135101.1	NP_001128573.1	Q6UXH1	CREL2_HUMAN	cysteine-rich with EGF-like domains 2	313						endoplasmic reticulum|extracellular region	calcium ion binding			endometrium(1)|large_intestine(1)|lung(3)|ovary(1)|stomach(3)	9		all_cancers(38;5.53e-07)|all_epithelial(38;3.84e-06)|all_lung(38;0.00208)|Breast(42;0.0104)|Lung NSC(38;0.0199)|Ovarian(80;0.0907)|Lung SC(80;0.236)		BRCA - Breast invasive adenocarcinoma(115;0.198)|LUAD - Lung adenocarcinoma(64;0.247)		ATACTCCAGGGAGCTACGTCT	0.507000													18	52					0	0	0.160694	0	0
ACTB	60	broad.mit.edu	37	7	5568921	5568921	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr7:5568921G>C	ENST00000331789.5	-	3	425	c.234C>G	c.(232-234)aaC>aaG	p.N78K		NM_001101.3	NP_001092.1	P60709	ACTB_HUMAN	actin, beta	78					'de novo' posttranslational protein folding|adherens junction organization|axon guidance|blood coagulation|cell junction assembly|cellular component movement	cytoskeleton|cytosol|MLL5-L complex|NuA4 histone acetyltransferase complex|ribonucleoprotein complex	ATP binding|kinesin binding|nitric-oxide synthase binding|structural constituent of cytoskeleton			NS(1)|central_nervous_system(1)|large_intestine(2)|lung(2)|prostate(2)	8		Ovarian(82;0.0606)		UCEC - Uterine corpus endometrioid carcinoma (126;0.175)|OV - Ovarian serous cystadenocarcinoma(56;4.24e-37)		TGTCGTCCCAGTTGGTGACGA	0.607000													33	48					0	0	0.183431	0	0
KIAA2026	158358	broad.mit.edu	37	9	5968103	5968103	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr9:5968103G>C	ENST00000399933.3	-	3	2127	c.2128C>G	c.(2128-2130)Ctt>Gtt	p.L710V	KIAA2026_ENST00000381461.2_Missense_Mutation_p.L710V	NM_001017969.2	NP_001017969.2	Q5HYC2	K2026_HUMAN	KIAA2026	710	Lys-rich.									breast(6)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(11)|lung(15)|ovary(2)|prostate(2)|skin(1)	46		Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.00155)|Lung(218;0.124)		TTGAATGCAAGAGAATGAAGA	0.308000													3	6					0	0	0.115264	0	0
FGF19	9965	broad.mit.edu	37	11	69514326	69514326	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr11:69514326C>T	ENST00000294312.3	-	3	1120	c.355G>A	c.(355-357)Gac>Aac	p.D119N		NM_005117.2	NP_005108.1	O95750	FGF19_HUMAN	fibroblast growth factor 19	119					fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|negative regulation of bile acid biosynthetic process|nervous system development|positive regulation of cell proliferation|positive regulation of ERK1 and ERK2 cascade|positive regulation of glucose import|positive regulation of JNK cascade	extracellular region	fibroblast growth factor receptor binding|growth factor activity			large_intestine(2)|lung(2)|skin(2)	6	all_cancers(3;5.53e-114)|all_epithelial(3;1.34e-121)|Breast(3;9.28e-34)|all_lung(4;1.99e-21)|Lung NSC(4;4.65e-21)|Hepatocellular(3;6.15e-15)|Melanoma(5;1.89e-05)|Ovarian(3;0.0348)		Epithelial(3;3.05e-56)|all cancers(3;2.69e-50)|Lung(3;1.13e-16)|LUSC - Lung squamous cell carcinoma(11;3.74e-15)|STAD - Stomach adenocarcinoma(18;0.0278)|LUAD - Lung adenocarcinoma(13;0.0537)			AAAGCACAGTCTTCCTCCGAG	0.567000													10	17					0	0	0.069234	0	0
CELSR1	9620	broad.mit.edu	37	22	46776788	46776788	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr22:46776788G>C	ENST00000262738.3	-	22	7152	c.7153C>G	c.(7153-7155)Ccg>Gcg	p.P2385A		NM_014246.1	NP_055061.1	Q9NYQ6	CELR1_HUMAN	cadherin, EGF LAG seven-pass G-type receptor 1	2385					central nervous system development|homophilic cell adhesion|neural tube closure|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein dimerization activity			breast(8)|central_nervous_system(5)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(5)|kidney(4)|large_intestine(13)|lung(27)|ovary(2)|pancreas(2)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(3)	95		Ovarian(80;0.00142)|Breast(42;0.00296)|all_neural(38;0.0416)|Colorectal(5;0.0766)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00643)|BRCA - Breast invasive adenocarcinoma(115;0.171)		CTCGGGAGCGGAGCCCCCTCG	0.627000													13	27					0	0	0.119110	0	0
NPY4R	5540	broad.mit.edu	37	10	47087415	47087415	+	Missense_Mutation	SNP	G	G	A	rs147108354		TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr10:47087415G>A	ENST00000374312.1	+	3	1051	c.632G>A	c.(631-633)cGc>cAc	p.R211H	NPY4R_ENST00000395716.1_Missense_Mutation_p.R211H	NM_005972.4	NP_005963.3			neuropeptide Y receptor Y4																		GCTCACCACCGCACCATCTAC	0.582000													5	177					0	0	0.021553	0	0
CAMK1	8536	broad.mit.edu	37	3	9801205	9801205	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr3:9801205C>A	ENST00000256460.3	-	10	1056	c.879G>T	c.(877-879)caG>caT	p.Q293H	OGG1_ENST00000349503.5_Intron|OGG1_ENST00000449570.2_Intron|OGG1_ENST00000383826.5_Intron|OGG1_ENST00000302008.8_Intron|OGG1_ENST00000302036.7_Intron	NM_003656.4	NP_003647.1	Q14012	KCC1A_HUMAN	calcium/calmodulin-dependent protein kinase I	293	Autoinhibitory domain (By similarity).				cell differentiation|nervous system development|positive regulation of muscle cell differentiation|signal transduction	cytoplasm|nucleus	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			endometrium(1)|large_intestine(3)|lung(6)|ovary(1)|skin(1)	12	Medulloblastoma(99;0.227)			OV - Ovarian serous cystadenocarcinoma(96;0.0475)		TCTTCTTGATCTGCTCACTCA	0.527000													7	240					5.18039e-06	5.30373e-06	0.038147	1	0
PEX5L	51555	broad.mit.edu	37	3	179597776	179597776	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr3:179597776G>A	ENST00000467460.1	-	5	776	c.446C>T	c.(445-447)aCg>aTg	p.T149M	PEX5L_ENST00000464614.1_Intron|PEX5L_ENST00000392649.3_Intron|PEX5L_ENST00000263962.8_Missense_Mutation_p.T147M|PEX5L-AS1_ENST00000466064.1_RNA|PEX5L_ENST00000485199.1_Missense_Mutation_p.T114M|PEX5L_ENST00000468741.1_De_novo_Start_InFrame|PEX5L_ENST00000476138.1_Missense_Mutation_p.T106M|PEX5L_ENST00000472994.1_Missense_Mutation_p.T90M|PEX5L_ENST00000467440.2_Intron|PEX5L_ENST00000465751.1_Missense_Mutation_p.T125M	NM_001256751.1|NM_016559.2	NP_001243680.1|NP_057643.1	Q8IYB4	PEX5R_HUMAN	peroxisomal biogenesis factor 5-like	149					protein import into peroxisome matrix|regulation of cAMP-mediated signaling	cytosol|peroxisomal membrane	peroxisome matrix targeting signal-1 binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(23)|ovary(3)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	49	all_cancers(143;3.94e-14)|Ovarian(172;0.0338)|Breast(254;0.183)		OV - Ovarian serous cystadenocarcinoma(80;1.75e-26)|GBM - Glioblastoma multiforme(14;0.000518)			CTCAGCATCCGTGCTGATGAG	0.517000													12	131					0	0	0.105934	0	0
DLGAP1	9229	broad.mit.edu	37	18	3502477	3502477	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr18:3502477C>T	ENST00000581527.1	-	12	3264	c.2738G>A	c.(2737-2739)aGa>aAa	p.R913K	DLGAP1_ENST00000581699.1_Intron|DLGAP1_ENST00000539435.1_Intron|DLGAP1_ENST00000534970.1_Intron|DLGAP1_ENST00000515196.2_Missense_Mutation_p.R913K|DLGAP1_ENST00000400145.2_Missense_Mutation_p.R611K|DLGAP1_ENST00000400147.2_Intron|DLGAP1_ENST00000400149.3_Intron|DLGAP1_ENST00000400150.3_Intron|DLGAP1_ENST00000400155.1_Intron|DLGAP1_ENST00000315677.3_Intron|DLGAP1_ENST00000584874.1_Intron	NM_001242761.1	NP_001229690.1	O14490	DLGP1_HUMAN	discs, large (Drosophila) homolog-associated protein 1	0					synaptic transmission	cell junction|postsynaptic density|postsynaptic membrane				breast(2)|endometrium(3)|kidney(1)|large_intestine(5)|lung(31)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(6)|urinary_tract(1)	56		Colorectal(8;0.0257)				CATACAAAATCTACATTGTTC	0.348000													19	27					0	0	0.055883	0	0
LIFR	3977	broad.mit.edu	37	5	38504091	38504091	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr5:38504091G>A	ENST00000263409.4	-	10	1586	c.1424C>T	c.(1423-1425)tCa>tTa	p.S475L	LIFR_ENST00000503088.1_5'UTR|LIFR_ENST00000453190.2_Missense_Mutation_p.S475L	NM_002310.5	NP_002301.1	P42702	LIFR_HUMAN	leukemia inhibitory factor receptor alpha	475	Fibronectin type-III 3.				positive regulation of cell proliferation	extracellular region|integral to plasma membrane	ciliary neurotrophic factor receptor binding|growth factor binding|leukemia inhibitory factor receptor activity			NS(2)|breast(4)|endometrium(6)|kidney(2)|large_intestine(30)|liver(2)|lung(21)|ovary(3)|skin(5)|stomach(1)|urinary_tract(2)	78	all_lung(31;0.00021)					CTCTTGTACTGAATTAGATTT	0.284000			T	PLAG1	salivary adenoma								33	53					0	0	0.069456	0	0
DCDC1	341019	broad.mit.edu	37	11	31125289	31125289	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr11:31125289C>G	ENST00000597505.1	-	12	1778	c.1779G>C	c.(1777-1779)ttG>ttC	p.L593F	DCDC1_ENST00000437348.1_5'UTR			P59894	DCDC1_HUMAN	doublecortin domain containing 1	0					intracellular signal transduction					central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(17)|pancreas(2)|prostate(1)|skin(1)|stomach(1)	31	Lung SC(675;0.225)					GGTCAAAGGTCAAACCCAAAG	0.373000													26	58					0	0	0.134883	0	0
PPIL2	23759	broad.mit.edu	37	22	22049338	22049338	+	Missense_Mutation	SNP	A	A	T			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr22:22049338A>T	ENST00000406385.1	+	19	1505	c.1445A>T	c.(1444-1446)aAg>aTg	p.K482M	PPIL2_ENST00000398831.3_Missense_Mutation_p.K482M|PPIL2_ENST00000412327.1_Missense_Mutation_p.K482M|PPIL2_ENST00000492445.2_Missense_Mutation_p.K482M|PPIL2_ENST00000456792.2_Intron|PPIL2_ENST00000335025.7_Missense_Mutation_p.K482M			Q13356	PPIL2_HUMAN	peptidylprolyl isomerase (cyclophilin)-like 2	482					blood coagulation|leukocyte migration|protein folding|protein polyubiquitination	Golgi lumen|nucleus|ubiquitin ligase complex	peptidyl-prolyl cis-trans isomerase activity|ubiquitin-ubiquitin ligase activity			endometrium(4)|kidney(2)|large_intestine(4)|lung(3)|ovary(2)|skin(2)	17	Colorectal(54;0.105)					GGCGTGGGCAAGTACATCAAC	0.647000													5	25					0	0	0.014758	0	0
NAPEPLD	222236	broad.mit.edu	37	7	102743916	102743916	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr7:102743916C>T	ENST00000417955.1	-	5	1296	c.1142G>A	c.(1141-1143)gGa>gAa	p.G381E	NAPEPLD_ENST00000455523.2_Missense_Mutation_p.G454E|NAPEPLD_ENST00000465647.1_Missense_Mutation_p.G381E|NAPEPLD_ENST00000341533.4_Missense_Mutation_p.G381E|NAPEPLD_ENST00000427257.1_Missense_Mutation_p.G381E			Q6IQ20	NAPEP_HUMAN	N-acyl phosphatidylethanolamine phospholipase D	381					phospholipid catabolic process	membrane	metal ion binding			endometrium(2)|large_intestine(5)|lung(6)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	17						TCTTGATTCTCCATGCTTCAA	0.348000													29	59					0	0	0.125774	0	0
FBN1	2200	broad.mit.edu	37	15	48737641	48737641	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr15:48737641G>C	ENST00000316623.5	-	48	6304	c.5849C>G	c.(5848-5850)aCa>aGa	p.T1950R		NM_000138.4	NP_000129.3	P35555	FBN1_HUMAN	fibrillin 1	1950	EGF-like 33; calcium-binding.				heart development|negative regulation of BMP signaling pathway by extracellular sequestering of BMP|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|skeletal system development	basement membrane|extracellular space|microfibril	calcium ion binding|extracellular matrix structural constituent|protein binding			NS(1)|breast(5)|cervix(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(43)|liver(1)|lung(49)|ovary(4)|pancreas(1)|prostate(9)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	139		all_lung(180;0.00279)		all cancers(107;4.24e-07)|GBM - Glioblastoma multiforme(94;1.41e-05)		AGACCCCACTGTATTAATGCA	0.438000													41	59					0	0	0.111260	0	0
KIAA1598	57698	broad.mit.edu	37	10	118646072	118646072	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr10:118646072G>T	ENST00000355371.4	-	17	2176	c.1679C>A	c.(1678-1680)cCc>cAc	p.P560H	KIAA1598_ENST00000497044.1_5'UTR|ENO4_ENST00000369207.2_Intron|KIAA1598_ENST00000392903.2_Missense_Mutation_p.P560H|KIAA1598_ENST00000260777.10_Silent_p.S455S	NM_001127211.2|NM_001258298.1|NM_001258299.1	NP_001120683.1|NP_001245227.1|NP_001245228.1	A0MZ66	SHOT1_HUMAN	KIAA1598	560					axon guidance	axon				endometrium(1)|kidney(1)|large_intestine(5)|lung(3)	10				all cancers(201;0.00494)		AATGCTACTGGGAGGCCTATG	0.373000													26	48					4.7796e-09	5.10616e-09	0.099896	1	0
VSIG10	54621	broad.mit.edu	37	12	118506244	118506244	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr12:118506244C>G	ENST00000359236.5	-	8	1781	c.1505G>C	c.(1504-1506)aGa>aCa	p.R502T		NM_019086.5	NP_061959.2	Q8N0Z9	VSI10_HUMAN	V-set and immunoglobulin domain containing 10	502						integral to membrane				endometrium(5)|large_intestine(3)|lung(6)|skin(1)|stomach(1)|urinary_tract(1)	17						GGCGGTCACTCTGTGAATGTG	0.468000													37	77					0	0	0.074837	0	0
WDR82	80335	broad.mit.edu	37	3	52292653	52292653	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr3:52292653C>A	ENST00000296490.3	-	8	1092	c.811G>T	c.(811-813)Ggt>Tgt	p.G271C		NM_025222.3	NP_079498.2	Q6UXN9	WDR82_HUMAN	WD repeat domain 82	271					histone H3-K4 methylation	chromatin|PTW/PP1 phosphatase complex|Set1C/COMPASS complex	protein binding								BRCA - Breast invasive adenocarcinoma(193;2.67e-05)|Kidney(197;0.00198)|KIRC - Kidney renal clear cell carcinoma(197;0.00223)|OV - Ovarian serous cystadenocarcinoma(275;0.246)		ACTTTTATACCGCTCTCTCCA	0.448000													8	48					0.00307968	0.00311591	0.038147	1	0
PAX2	5076	broad.mit.edu	37	10	102568873	102568873	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr10:102568873G>A	ENST00000370296.2	+	8	1418	c.868G>A	c.(868-870)Gag>Aag	p.E290K	PAX2_ENST00000556085.1_Missense_Mutation_p.E266K|PAX2_ENST00000355243.3_Missense_Mutation_p.E267K|PAX2_ENST00000361791.3_Missense_Mutation_p.E267K|PAX2_ENST00000428433.1_Missense_Mutation_p.E290K			Q02962	PAX2_HUMAN	paired box 2	290					anti-apoptosis|axonogenesis|brain morphogenesis|branching involved in ureteric bud morphogenesis|cell fate determination|cellular response to glucose stimulus|cellular response to hydrogen peroxide|cellular response to retinoic acid|cochlea development|glial cell differentiation|inner ear morphogenesis|mesenchymal to epithelial transition involved in metanephros morphogenesis|mesodermal cell fate specification|mesonephros development|metanephric collecting duct development|metanephric distal convoluted tubule development|metanephric mesenchymal cell differentiation|metanephric nephron tubule formation|negative regulation of caspase activity|negative regulation of cytolysis|negative regulation of mesenchymal stem cell apoptosis involved in metanephric nephron morphogenesis|negative regulation of reactive oxygen species metabolic process|negative regulation of transcription, DNA-dependent|nephric duct formation|neural tube closure|optic chiasma development|optic cup morphogenesis involved in camera-type eye development|optic nerve structural organization|positive regulation of branching involved in ureteric bud morphogenesis|positive regulation of epithelial cell proliferation|positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis|positive regulation of metanephric DCT cell differentiation|positive regulation of metanephric glomerulus development|positive regulation of optic nerve formation|positive regulation of transcription from RNA polymerase II promoter|pronephric field specification|protein kinase B signaling cascade|reactive oxygen species metabolic process|regulation of metanephric nephron tubule epithelial cell differentiation|regulation of metanephros size|retinal pigment epithelium development|stem cell differentiation|transcription from RNA polymerase II promoter|ureter maturation|vestibulocochlear nerve formation|visual perception	centriolar satellite|nucleus|protein complex|protein-DNA complex	core promoter proximal region sequence-specific DNA binding|superoxide-generating NADPH oxidase activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(10)|prostate(1)|upper_aerodigestive_tract(1)	18		Colorectal(252;0.234)		Epithelial(162;1.32e-08)|all cancers(201;7.32e-07)		CCAGGGGAACGAGTACTCCCT	0.587000													40	111					0	0	0.111260	0	0
PGK1	5230	broad.mit.edu	37	X	77380864	77380864	+	Silent	SNP	G	G	T			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chrX:77380864G>T	ENST00000373316.4	+	10	1322	c.1155G>T	c.(1153-1155)acG>acT	p.T385T	PGK1_ENST00000537456.1_Silent_p.T357T|PGK1_ENST00000476531.1_3'UTR|PGK1_ENST00000442431.1_Silent_p.T249T	NM_000291.3	NP_000282.1	P00558	PGK1_HUMAN	phosphoglycerate kinase 1	385					gluconeogenesis|glycolysis	cytosol	ATP binding|phosphoglycerate kinase activity			breast(1)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(5)|lung(10)|ovary(1)|upper_aerodigestive_tract(1)	24						AATGGAACACGGAGGATAAAG	0.488000													44	20					4.44712e-29	4.87201e-29	0.139131	1	0
WBSCR17	64409	broad.mit.edu	37	7	70597882	70597882	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr7:70597882G>A	ENST00000333538.5	+	1	728	c.94G>A	c.(94-96)Gcg>Acg	p.A32T		NM_022479.1	NP_071924.1	Q6IS24	GLTL3_HUMAN	Williams-Beuren syndrome chromosome region 17	32						Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			NS(5)|breast(2)|central_nervous_system(1)|endometrium(7)|kidney(7)|large_intestine(22)|lung(45)|ovary(2)|pancreas(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)	100		all_cancers(73;0.2)|Lung NSC(55;0.094)|all_lung(88;0.125)				CCGGCCCATCGCGGTGCGCAG	0.637000													9	16					0	0	0.069234	0	0
GSTA2	2939	broad.mit.edu	37	6	52615381	52615381	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr6:52615381C>A	ENST00000493422.1	-	7	818	c.663G>T	c.(661-663)agG>agT	p.R221S		NM_000846.4	NP_000837.3	P09210	GSTA2_HUMAN	glutathione S-transferase alpha 2	221					glutathione metabolic process|xenobiotic metabolic process	cytosol	glutathione transferase activity	p.R221S(1)		breast(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(4)|ovary(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	16	Lung NSC(77;0.118)				Aminophenazone(DB01424)|Amsacrine(DB00276)|Busulfan(DB01008)|Chlorambucil(DB00291)|Chloroquine(DB00608)|Cinnarizine(DB00568)|Clofibrate(DB00636)|Ethacrynic acid(DB00903)|Glutathione(DB00143)|Mechlorethamine(DB00888)|Praziquantel(DB01058)|Vitamin E(DB00163)	TTTATTAAAACCTGAAAATCT	0.413000													8	101					1.11149e-13	1.20237e-13	0.069234	1	0
CORO6	84940	broad.mit.edu	37	17	27943190	27943190	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr17:27943190C>G	ENST00000345068.5	-	10	1279	c.1066G>C	c.(1066-1068)Gac>Cac	p.D356H	RP11-68I3.2_ENST00000581474.1_RNA|CORO6_ENST00000445145.2_Missense_Mutation_p.D356H|CORO6_ENST00000577909.1_5'UTR|CORO6_ENST00000584969.1_Missense_Mutation_p.D356H|CORO6_ENST00000580212.1_Missense_Mutation_p.D316H|CORO6_ENST00000456796.3_Missense_Mutation_p.D122H|CORO6_ENST00000388767.3_Missense_Mutation_p.D356H			Q6QEF8	CORO6_HUMAN	coronin 6	356					actin cytoskeleton organization	actin cytoskeleton	actin filament binding			breast(1)|cervix(1)|endometrium(1)|large_intestine(4)|lung(4)|prostate(1)|urinary_tract(2)	14						TGGAAGAGGTCTGACTGCGGG	0.677000													7	14					0	0	0.029380	0	0
PRKCQ	5588	broad.mit.edu	37	10	6506278	6506278	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr10:6506278G>A	ENST00000263125.5	-	13	1541	c.1442C>T	c.(1441-1443)gCg>gTg	p.A481V	PRKCQ_ENST00000539722.1_Missense_Mutation_p.A356V|PRKCQ_ENST00000397176.2_Missense_Mutation_p.A481V	NM_006257.3	NP_006248.1	Q04759	KPCT_HUMAN	protein kinase C, theta	481	Protein kinase.				axon guidance|cellular component disassembly involved in apoptosis|intracellular signal transduction|membrane protein ectodomain proteolysis|platelet activation|regulation of cell growth|T cell receptor signaling pathway	cytosol	ATP binding|metal ion binding|protein binding|protein kinase C activity			NS(1)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|liver(1)|lung(13)|ovary(4)|prostate(1)|skin(4)|stomach(2)	45						CTCTTACGTCGCTCTGGAAAG	0.448000													88	275					0	0	0.139131	0	0
SIMC1	375484	broad.mit.edu	37	5	175740719	175740719	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr5:175740719T>C	ENST00000443967.1	+	7	2110	c.1703T>C	c.(1702-1704)cTt>cCt	p.L568P	SIMC1_ENST00000332772.4_Missense_Mutation_p.L29P|SIMC1_ENST00000341199.6_Missense_Mutation_p.L153P|SIMC1_ENST00000430704.2_Missense_Mutation_p.L153P					SUMO-interacting motifs containing 1																		GGGCGAGTCCTTTTCCTGCGT	0.488000													4	313					0	0	0.150653	0	0
FRG1BP	284802	broad.mit.edu	37	20	29628263	29628263	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr20:29628263A>G	ENST00000278882.3	+	6	645	c.265A>G	c.(265-267)Att>Gtt	p.I89V	FRG1B_ENST00000358464.4_Missense_Mutation_p.I89V|FRG1B_ENST00000439954.2_Missense_Mutation_p.I94V														p.I89V(4)		endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						TAGCTGCTTTATTAGATGCAA	0.363000													5	63					0	0	0.014758	0	0
ANK3	288	broad.mit.edu	37	10	61831482	61831482	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr10:61831482C>G	ENST00000280772.1	-	37	9348	c.9157G>C	c.(9157-9159)Gag>Cag	p.E3053Q	ANK3_ENST00000355288.2_Intron|ANK3_ENST00000503366.1_Intron|ANK3_ENST00000373827.2_Intron	NM_020987.3	NP_066267.2	Q12955	ANK3_HUMAN	ankyrin 3, node of Ranvier (ankyrin G)	3053					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						GGGCTAAACTCTAAAGAATCA	0.473000													56	82					0	0	0.139131	0	0
ZNF331	55422	broad.mit.edu	37	19	54080933	54080933	+	Silent	SNP	C	C	T			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr19:54080933C>T	ENST00000253144.9	+	7	2452	c.1119C>T	c.(1117-1119)caC>caT	p.H373H	ZNF331_ENST00000513999.1_Silent_p.H373H|ZNF331_ENST00000449416.1_Silent_p.H373H|ZNF331_ENST00000511593.2_Silent_p.H373H|ZNF331_ENST00000411977.2_Silent_p.H373H|ZNF331_ENST00000511154.1_Silent_p.H373H|ZNF331_ENST00000513265.1_3'UTR|ZNF331_ENST00000512387.1_Silent_p.H373H	NM_001253801.1|NM_018555.5	NP_001240730.1|NP_061025.5	Q9NQX6	ZN331_HUMAN	zinc finger protein 331	373					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|large_intestine(1)|lung(1)|ovary(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	10				GBM - Glioblastoma multiforme(134;0.00555)		TCACTCAGCACGAGAGAATCC	0.498000			T	?	follicular thyroid adenoma								7	39					0	0	0.038147	0	0
PCDHA11	56138	broad.mit.edu	37	5	140250408	140250408	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr5:140250408G>A	ENST00000398640.2	+	1	1720	c.1720G>A	c.(1720-1722)Ggc>Agc	p.G574S	PCDHA8_ENST00000531613.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA10_ENST00000307360.5_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA10_ENST00000506939.2_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA2_ENST00000526136.1_Intron	NM_018902.3	NP_061725.1														breast(1)|lung(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CAGCGCGGGAGGCGCAGTTAA	0.667000													64	73					0	0	0.139131	0	0
TAS2R31	259290	broad.mit.edu	37	12	11183373	11183373	+	Missense_Mutation	SNP	A	A	T			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr12:11183373A>T	ENST00000390675.2	-	1	633	c.562T>A	c.(562-564)Ttc>Atc	p.F188I	PRR4_ENST00000536668.1_Intron|TAS2R14_ENST00000381852.4_Intron	NM_176885.2	NP_795366.2	P59538	T2R31_HUMAN	taste receptor, type 2, member 31	188					sensory perception of taste	integral to membrane	G-protein coupled receptor activity			kidney(1)|lung(6)	7						GTCAGAGTGAAGGGCACTAAG	0.428000													41	92					0	0	0.104719	0	0
FAM71F1	84691	broad.mit.edu	37	7	128359081	128359081	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr7:128359081C>G	ENST00000315184.5	+	3	684	c.631C>G	c.(631-633)Ctt>Gtt	p.L211V	FAM71F1_ENST00000485070.1_Missense_Mutation_p.L112V|FAM71F1_ENST00000469348.1_3'UTR	NM_032599.2	NP_115988.1	Q96KD3	F71F1_HUMAN	family with sequence similarity 71, member F1	211										NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(6)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	18						CCCTAGGATTCTTGTCACGCA	0.542000													5	105					0	0	0.014758	0	0
ST6GALNAC1	55808	broad.mit.edu	37	17	74625693	74625693	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr17:74625693C>T	ENST00000156626.7	-	2	431	c.232G>A	c.(232-234)Gag>Aag	p.E78K	ST6GALNAC1_ENST00000590878.1_5'UTR	NM_018414.3	NP_060884.1	Q9NSC7	SIA7A_HUMAN	ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1	78					protein glycosylation	integral to Golgi membrane	alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity			breast(2)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(11)|prostate(1)|upper_aerodigestive_tract(1)	22						GGCACTGGCTCTGCATAGATG	0.567000													53	88					0	0	0.139131	0	0
ANK3	288	broad.mit.edu	37	10	61828403	61828403	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr10:61828403C>G	ENST00000280772.1	-	37	12427	c.12236G>C	c.(12235-12237)aGa>aCa	p.R4079T	ANK3_ENST00000355288.2_Intron|ANK3_ENST00000503366.1_Intron|ANK3_ENST00000373827.2_Intron	NM_020987.3	NP_066267.2	Q12955	ANK3_HUMAN	ankyrin 3, node of Ranvier (ankyrin G)	4079					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						ACCAGTCCTTCTACTGCTCCT	0.473000													56	100					0	0	0.139131	0	0
CTSS	1520	broad.mit.edu	37	1	150724458	150724458	+	Silent	SNP	G	G	A			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr1:150724458G>A	ENST00000368985.3	-	5	686	c.426C>T	c.(424-426)ttC>ttT	p.F142F	CTSS_ENST00000480760.1_5'UTR|CTSS_ENST00000448301.2_Silent_p.F92F	NM_001199739.1|NM_004079.4	NP_001186668.1|NP_004070.3	P25774	CATS_HUMAN	cathepsin S	142					immune response|proteolysis	extracellular region|lysosome	cysteine-type endopeptidase activity			cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(5)|skin(1)|stomach(1)|urinary_tract(1)	15	all_cancers(9;6.17e-52)|all_epithelial(9;9.7e-43)|all_lung(15;5.74e-35)|Lung NSC(24;2.09e-31)|Breast(34;0.00146)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Melanoma(130;0.128)|Colorectal(459;0.171)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0485)|Epithelial(6;5.02e-21)|all cancers(9;1.28e-20)|OV - Ovarian serous cystadenocarcinoma(6;1.09e-14)|BRCA - Breast invasive adenocarcinoma(12;0.00501)|LUSC - Lung squamous cell carcinoma(543;0.171)			CCACAGCACTGAAAGCCCAGC	0.478000													15	32					0	0	0.175082	0	0
PCDH7	5099	broad.mit.edu	37	4	30723353	30723353	+	Silent	SNP	C	C	T			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr4:30723353C>T	ENST00000361762.2	+	1	1317	c.309C>T	c.(307-309)ttC>ttT	p.F103F	PCDH7_ENST00000543491.1_Silent_p.F103F	NM_002589.2	NP_002580.2	O60245	PCDH7_HUMAN	protocadherin 7	103	Cadherin 1.				homophilic cell adhesion	integral to plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(8)|liver(1)|lung(26)|ovary(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	55						AGATGATCTTCGACGAGAACG	0.602000													11	10					0	0	0.093190	0	0
PCBP2	5094	broad.mit.edu	37	12	53861083	53861083	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr12:53861083G>C	ENST00000541275.1	+	13	1342	c.793G>C	c.(793-795)Gat>Cat	p.D265H	PCBP2_ENST00000437231.1_Intron|PCBP2_ENST00000549863.1_Intron|PCBP2_ENST00000548933.1_Intron|PCBP2_ENST00000359462.5_Intron|PCBP2_ENST00000359282.5_Intron|RP11-793H13.8_ENST00000547717.1_RNA|PCBP2_ENST00000546463.1_Intron|PCBP2_ENST00000455667.3_Intron|PCBP2_ENST00000447282.1_Intron|PCBP2_ENST00000439930.3_Intron|PCBP2_ENST00000603815.1_Intron|PCBP2_ENST00000552819.1_Intron|PCBP2_ENST00000552296.2_Intron			Q15366	PCBP2_HUMAN	poly(rC) binding protein 2	269					innate immune response|negative regulation of defense response to virus|negative regulation of type I interferon production|nuclear mRNA splicing, via spliceosome|proteasomal ubiquitin-dependent protein catabolic process|response to virus	cytosol|nucleoplasm|ribonucleoprotein complex	DNA binding|RNA binding|ubiquitin protein ligase binding			central_nervous_system(4)|endometrium(2)|kidney(1)|large_intestine(2)|lung(4)|skin(1)|upper_aerodigestive_tract(1)	15						CAGTGGTATGGATACCTCAGT	0.468000													39	60					0	0	0.139131	0	0
GFRA3	2676	broad.mit.edu	37	5	137599972	137599972	+	Silent	SNP	G	G	A			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr5:137599972G>A	ENST00000274721.3	-	2	603	c.357C>T	c.(355-357)acC>acT	p.T119T	GFRA3_ENST00000378362.3_Silent_p.T119T	NM_001496.3	NP_001487.2	O60609	GFRA3_HUMAN	GDNF family receptor alpha 3	119					peripheral nervous system development	anchored to membrane|cytoplasm|extrinsic to membrane|intracellular membrane-bounded organelle	receptor binding			central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(4)|ovary(1)	12			KIRC - Kidney renal clear cell carcinoma(527;0.004)|Kidney(363;0.00592)			CACGGTGAACGGTCCAATAGA	0.552000													25	49					0	0	0.116897	0	0
PLCB3	5331	broad.mit.edu	37	11	64022744	64022744	+	Silent	SNP	C	C	T			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr11:64022744C>T	ENST00000540288.1	+	5	529	c.426C>T	c.(424-426)atC>atT	p.I142I	PLCB3_ENST00000279230.6_Silent_p.I142I|PLCB3_ENST00000325234.5_Silent_p.I75I	NM_000932.2	NP_000923.1	Q01970	PLCB3_HUMAN	phospholipase C, beta 3 (phosphatidylinositol-specific)	142					intracellular signal transduction|lipid catabolic process|synaptic transmission	cytosol	calcium ion binding|calmodulin binding|phosphatidylinositol phospholipase C activity|signal transducer activity			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(14)|ovary(1)|pancreas(1)|prostate(3)|urinary_tract(1)	33						CTATGAACATCCTGGCTCAGA	0.647000													11	22					0	0	0.069234	0	0
ANK3	288	broad.mit.edu	37	10	61831782	61831782	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr10:61831782C>T	ENST00000280772.1	-	37	9048	c.8857G>A	c.(8857-8859)Gag>Aag	p.E2953K	ANK3_ENST00000355288.2_Intron|ANK3_ENST00000503366.1_Intron|ANK3_ENST00000373827.2_Intron	NM_020987.3	NP_066267.2	Q12955	ANK3_HUMAN	ankyrin 3, node of Ranvier (ankyrin G)	2953					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						GCTGAGCTCTCGCTCCTCCTG	0.468000													24	54					0	0	0.108266	0	0
ICA1	3382	broad.mit.edu	37	7	8196806	8196806	+	Silent	SNP	A	A	T			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr7:8196806A>T	ENST00000402384.3	-	8	1010	c.744T>A	c.(742-744)acT>acA	p.T248T	ICA1_ENST00000396675.3_Silent_p.T248T|ICA1_ENST00000401396.1_Silent_p.T236T|ICA1_ENST00000406470.2_Silent_p.T248T|ICA1_ENST00000407906.1_Silent_p.T248T|ICA1_ENST00000422063.2_Silent_p.T248T|ICA1_ENST00000265577.7_Silent_p.T247T			Q05084	ICA69_HUMAN	islet cell autoantigen 1, 69kDa	248	AH.				neurotransmitter transport	cell junction|cytosol|Golgi membrane|nucleus|secretory granule membrane|synaptic vesicle membrane|transport vesicle membrane				breast(1)|central_nervous_system(2)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(8)|urinary_tract(1)	23		Ovarian(82;0.0612)		UCEC - Uterine corpus endometrioid carcinoma (126;0.246)		TGGCTGCCATAGTGTGAGAAG	0.398000													6	88					0	0	0.029380	0	0
DNAJA4	55466	broad.mit.edu	37	15	78557113	78557113	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr15:78557113A>G	ENST00000394855.3	+	2	323	c.95A>G	c.(94-96)aAg>aGg	p.K32R	DNAJA4_ENST00000489435.2_Missense_Mutation_p.K32R|DNAJA4_ENST00000394852.3_Missense_Mutation_p.K3R|DNAJA4_ENST00000343789.3_Missense_Mutation_p.K3R	NM_018602.3	NP_061072.3	Q8WW22	DNJA4_HUMAN	DnaJ (Hsp40) homolog, subfamily A, member 4	3	J.				protein folding|response to heat	membrane	ATP binding|heat shock protein binding|metal ion binding|unfolded protein binding			NS(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(1)|ovary(1)|skin(1)	8						AAGATGGTGAAGGAGACCCAG	0.716000													3	13					0	0	0.115264	0	0
TTN	7273	broad.mit.edu	37	2	179529439	179529439	+	Silent	SNP	G	G	T			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr2:179529439G>T	ENST00000589042.1	-	167	36368	c.36144C>A	c.(36142-36144)gtC>gtA	p.V12048V	TTN_ENST00000342175.6_Intron|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000589487.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000431752.1_RNA|TTN_ENST00000591111.1_Intron|TTN-AS1_ENST00000589830.1_RNA|TTN_ENST00000359218.5_Intron|TTN_ENST00000342992.6_Intron|TTN_ENST00000460472.2_Intron	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	10196	Ig-like 80.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCTTTTCAGGGACAATTTCTT	0.383000													8	56					1.06961e-07	1.12179e-07	0.038147	1	0
SEMA5B	54437	broad.mit.edu	37	3	122629104	122629104	+	Silent	SNP	G	G	A			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr3:122629104G>A	ENST00000357599.3	-	23	3728	c.3342C>T	c.(3340-3342)ttC>ttT	p.F1114F	SEMA5B_ENST00000195173.4_3'UTR|SEMA5B_ENST00000451055.2_Silent_p.F1168F	NM_001031702.3|NM_001256348.1	NP_001026872.2|NP_001243277.1	Q9P283	SEM5B_HUMAN	sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5B	1114					cell differentiation|nervous system development	integral to membrane	receptor activity			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(13)|lung(26)|ovary(2)|pancreas(3)|skin(2)|upper_aerodigestive_tract(3)	55				GBM - Glioblastoma multiforme(114;0.0367)		GCAATGGGTAGAAGTTGGCTC	0.537000													41	129					0	0	0.117977	0	0
YPEL1	29799	broad.mit.edu	37	22	22057704	22057704	+	Silent	SNP	G	G	A			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr22:22057704G>A	ENST00000339468.3	-	4	608	c.225C>T	c.(223-225)gcC>gcT	p.A75A		NM_013313.3	NP_037445.1	O60688	YPEL1_HUMAN	yippee-like 1 (Drosophila)	75						nucleus				breast(1)|large_intestine(1)|lung(1)	3	Colorectal(54;0.105)					AGTAGATGTCGGCAACCGCAT	0.642000													32	70					0	0	0.173368	0	0
SLC35G3	146861	broad.mit.edu	37	17	33520392	33520392	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr17:33520392G>C	ENST00000297307.5	-	1	1020	c.935C>G	c.(934-936)gCg>gGg	p.A312G		NM_152462.2	NP_689675.1	Q8N808	AMAC1_HUMAN	solute carrier family 35, member G3	312	DUF6 2.					integral to membrane		p.A312G(4)									AACCCCTGCCGCCACGATGTC	0.567000													6	140					0	0	0.029380	0	0
CRELD2	79174	broad.mit.edu	37	22	50319169	50319169	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr22:50319169G>A	ENST00000404488.3	+	10	1255	c.1120G>A	c.(1120-1122)Gaa>Aaa	p.E374K	CRELD2_ENST00000403427.3_Missense_Mutation_p.E297K|CRELD2_ENST00000407217.3_Missense_Mutation_p.E293K|CRELD2_ENST00000328268.4_Missense_Mutation_p.E325K	NM_001135101.1	NP_001128573.1	Q6UXH1	CREL2_HUMAN	cysteine-rich with EGF-like domains 2	325						endoplasmic reticulum|extracellular region	calcium ion binding			endometrium(1)|large_intestine(1)|lung(3)|ovary(1)|stomach(3)	9		all_cancers(38;5.53e-07)|all_epithelial(38;3.84e-06)|all_lung(38;0.00208)|Breast(42;0.0104)|Lung NSC(38;0.0199)|Ovarian(80;0.0907)|Lung SC(80;0.236)		BRCA - Breast invasive adenocarcinoma(115;0.198)|LUAD - Lung adenocarcinoma(64;0.247)		CGGCTTCGAAGAAACGGAAGA	0.587000													19	43					0	0	0.069288	0	0
ANK3	288	broad.mit.edu	37	10	61831953	61831953	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr10:61831953C>T	ENST00000280772.1	-	37	8877	c.8686G>A	c.(8686-8688)Gaa>Aaa	p.E2896K	ANK3_ENST00000355288.2_Intron|ANK3_ENST00000503366.1_Intron|ANK3_ENST00000373827.2_Intron	NM_020987.3	NP_066267.2	Q12955	ANK3_HUMAN	ankyrin 3, node of Ranvier (ankyrin G)	2896					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						GACATAAATTCATTCTTTTGA	0.353000													20	52					0	0	0.069288	0	0
CCDC42	146849	broad.mit.edu	37	17	8638891	8638891	+	Silent	SNP	C	C	A			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr17:8638891C>A	ENST00000293845.3	-	5	757	c.531G>T	c.(529-531)acG>acT	p.T177T	CCDC42_ENST00000539522.2_Intron	NM_144681.2	NP_653282.2	Q96M95	CCD42_HUMAN	coiled-coil domain containing 42	177				Missing (in Ref. 2; AAH29224).						kidney(1)|large_intestine(4)|lung(3)|ovary(1)	9						TGCTCACCAGCGTCTTGTAGC	0.627000													16	20					1.99824e-07	2.08301e-07	0.160694	1	0
CMTR1	23070	broad.mit.edu	37	6	37429416	37429416	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr6:37429416G>A	ENST00000373451.4	+	11	1351	c.1187G>A	c.(1186-1188)cGg>cAg	p.R396Q	FTSJD2_ENST00000493656.1_3'UTR	NM_015050.2	NP_055865.1	Q8N1G2	MTR1_HUMAN		396					mRNA capping	cytoplasm|nucleus	mRNA (nucleoside-2'-O-)-methyltransferase activity|nucleic acid binding			breast(3)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(10)|lung(6)|ovary(2)|pancreas(2)|upper_aerodigestive_tract(2)	31						TCCATTGTCCGGACAGGTGAC	0.537000													3	74					0	0	0.150653	0	0
RECK	8434	broad.mit.edu	37	9	36117110	36117110	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr9:36117110A>G	ENST00000377966.3	+	17	2755	c.2189A>G	c.(2188-2190)gAg>gGg	p.E730G		NM_021111.2	NP_066934.1	O95980	RECK_HUMAN	reversion-inducing-cysteine-rich protein with kazal motifs	730	Kazal-like 2.					anchored to membrane|peripheral to membrane of membrane fraction|plasma membrane	metalloendopeptidase inhibitor activity|serine-type endopeptidase inhibitor activity			cervix(1)|endometrium(7)|kidney(3)|large_intestine(6)|lung(10)|ovary(1)|pancreas(1)|skin(2)|stomach(1)	32			LUSC - Lung squamous cell carcinoma(32;0.112)|STAD - Stomach adenocarcinoma(86;0.228)			GACCACATGGAGCACAACAAT	0.453000													5	52					0	0	0.021553	0	0
TTN	7273	broad.mit.edu	37	2	179529438	179529438	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr2:179529438G>A	ENST00000589042.1	-	167	36369	c.36145C>T	c.(36145-36147)Cct>Tct	p.P12049S	TTN_ENST00000342175.6_Intron|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000589487.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000431752.1_RNA|TTN_ENST00000591111.1_Intron|TTN-AS1_ENST00000589830.1_RNA|TTN_ENST00000359218.5_Intron|TTN_ENST00000342992.6_Intron|TTN_ENST00000460472.2_Intron	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	10197	Ig-like 80.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTCTTTTCAGGGACAATTTCT	0.383000													9	56					0	0	0.047766	0	0
CIITA	4261	broad.mit.edu	37	16	10995908	10995908	+	Silent	SNP	T	T	A			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr16:10995908T>A	ENST00000324288.8	+	7	628	c.495T>A	c.(493-495)acT>acA	p.T165T	CIITA_ENST00000537380.1_3'UTR|CIITA_ENST00000381835.5_Intron	NM_000246.3	NP_000237.2	P33076	C2TA_HUMAN	class II, major histocompatibility complex, transactivator	165					interferon-gamma-mediated signaling pathway|negative regulation of transcription from RNA polymerase II promoter|positive regulation of MHC class I biosynthetic process|positive regulation of transcription from RNA polymerase II promoter|response to antibiotic|transcription, DNA-dependent	nucleus	activating transcription factor binding|ATP binding|protein C-terminus binding|protein complex binding|transcription coactivator activity|transcription regulatory region DNA binding			central_nervous_system(1)|large_intestine(7)|ovary(1)|skin(1)|stomach(2)	12						AGCCCCCCACTGTGGTGACTG	0.647000			T	"""FLJ27352, CD274, CD273, RALGDS, RUNDC2A, C16orf75, BCL6"""	"""PMBL, Hodgkin Lymphona, """								4	127					0	0	0.150653	0	0
APOA5	116519	broad.mit.edu	37	11	116661546	116661546	+	Silent	SNP	C	C	T			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr11:116661546C>T	ENST00000542499.1	-	4	471	c.399G>A	c.(397-399)acG>acA	p.T133T	APOA5_ENST00000227665.4_Silent_p.T133T	NM_001166598.1|NM_052968.4	NP_001160070.1|NP_443200.2	Q6Q788	APOA5_HUMAN	apolipoprotein A-V	133					acylglycerol homeostasis|cholesterol homeostasis|lipid transport|lipoprotein metabolic process|positive regulation of fatty acid biosynthetic process|positive regulation of lipoprotein lipase activity|positive regulation of receptor-mediated endocytosis|positive regulation of triglyceride catabolic process|positive regulation of very-low-density lipoprotein particle remodeling|tissue regeneration|triglyceride catabolic process|triglyceride homeostasis	chylomicron|high-density lipoprotein particle|very-low-density lipoprotein particle	enzyme binding|heparin binding|lipoprotein lipase activator activity|low-density lipoprotein particle receptor binding|phosphatidylcholine binding			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(8)|urinary_tract(1)	14	all_hematologic(175;0.0487)	all_cancers(61;3.31e-09)|all_epithelial(67;8.03e-06)|Breast(348;0.0126)|Melanoma(852;0.0153)|Acute lymphoblastic leukemia(157;0.0257)|Medulloblastoma(222;0.0425)|all_hematologic(158;0.0433)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|Epithelial(105;4.93e-06)|all cancers(92;0.000123)|OV - Ovarian serous cystadenocarcinoma(223;0.149)		TCAGATCCATCGTGTAGGGCT	0.652000													28	17					0	0	0.134883	0	0
ECSCR	641700	broad.mit.edu	37	5	138842247	138842247	+	Silent	SNP	G	G	A			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr5:138842247G>A	ENST00000515823.1	-	1	81	c.9C>T	c.(7-9)acC>acT	p.T3T		NM_001077693.2	NP_001071161.1	Q19T08	ECSCR_HUMAN	endothelial cell surface expressed chemotaxis and apoptosis regulator	3					angiogenesis|cell differentiation|chemotaxis	integral to membrane|plasma membrane											TGGCTCCTGCGGTGCCCATGT	0.632000													5	7					0	0	0.029380	0	0
KIF5C	3800	broad.mit.edu	37	2	149838001	149838001	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr2:149838001G>A	ENST00000435030.1	+	14	1863	c.1495G>A	c.(1495-1497)Gac>Aac	p.D499N	KIF5C_ENST00000464066.1_3'UTR|KIF5C_ENST00000414838.2_Missense_Mutation_p.D404N|KIF5C_ENST00000397413.1_Missense_Mutation_p.D267N			O60282	KIF5C_HUMAN	kinesin family member 5C	499					microtubule-based movement|organelle organization	cytoplasm|kinesin complex|microtubule	ATP binding|microtubule motor activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(13)|lung(12)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	36				BRCA - Breast invasive adenocarcinoma(221;0.108)		TGTCAATTATGACCAGAAATC	0.532000													6	7					0	0	0.029380	0	0
ATP5S	27109	broad.mit.edu	37	14	50789270	50789270	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr14:50789270C>T	ENST00000245448.6	+	3	886	c.194C>T	c.(193-195)gCg>gTg	p.A65V	ATP5S_ENST00000554438.1_3'UTR|ATP5S_ENST00000358473.1_Missense_Mutation_p.A37V|ATP5S_ENST00000426751.2_Missense_Mutation_p.A65V|ATP5S_ENST00000311459.7_Missense_Mutation_p.A65V	NM_001003805.2	NP_001003805.1	Q99766	ATP5S_HUMAN	ATP synthase, H+ transporting, mitochondrial Fo complex, subunit s (factor B)	65					ATP biosynthetic process	mitochondrial inner membrane|proton-transporting ATP synthase complex, coupling factor F(o)	hydrogen ion transmembrane transporter activity			breast(2)|kidney(1)|large_intestine(2)|liver(1)|lung(2)|ovary(1)|skin(2)|stomach(1)	12	all_epithelial(31;0.000636)|Breast(41;0.0102)			OV - Ovarian serous cystadenocarcinoma(311;0.0685)		CCTGACAGGGCGGCATCCGAG	0.527000													20	40					0	0	0.062417	0	0
CDKN1B	1027	broad.mit.edu	37	12	12871106	12871106	+	Silent	SNP	G	G	A			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr12:12871106G>A	ENST00000228872.4	+	1	1049	c.333G>A	c.(331-333)ggG>ggA	p.G111G	CDKN1B_ENST00000477087.1_Intron|CDKN1B_ENST00000396340.1_Silent_p.G111G	NM_004064.3	NP_004055.1	P46527	CDN1B_HUMAN	cyclin-dependent kinase inhibitor 1B (p27, Kip1)	111					autophagic cell death|cell cycle arrest|cellular response to lithium ion|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|negative regulation of transcription, DNA-dependent|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of protein catabolic process|S phase of mitotic cell cycle	cytosol|endosome|nucleoplasm	cyclin-dependent protein kinase inhibitor activity|protein phosphatase binding|transforming growth factor beta receptor, cytoplasmic mediator activity			breast(1)|large_intestine(3)|lung(3)|ovary(1)|prostate(5)	13		Prostate(47;0.0322)|all_epithelial(100;0.159)		BRCA - Breast invasive adenocarcinoma(232;0.0336)		ATGTCAGCGGGAGCCGCCCGG	0.647000													32	42					0	0	0.163468	0	0
PTAR1	375743	broad.mit.edu	37	9	72338300	72338300	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr9:72338300C>G	ENST00000377200.5	-	4	654	c.652G>C	c.(652-654)Gaa>Caa	p.E218Q	PTAR1_ENST00000340434.4_Missense_Mutation_p.E297Q			Q7Z6K3	PTAR1_HUMAN	protein prenyltransferase alpha subunit repeat containing 1	297					protein prenylation		protein prenyltransferase activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)	5						GTGCTGAATTCAACTTCTTCT	0.408000													59	90					0	0	0.139131	0	0
KIF26B	55083	broad.mit.edu	37	1	245850334	245850334	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr1:245850334C>G	ENST00000366518.4	+	9	3010	c.2906C>G	c.(2905-2907)tCt>tGt	p.S969C	KIF26B_ENST00000407071.2_Missense_Mutation_p.S1350C			Q2KJY2	KI26B_HUMAN	kinesin family member 26B	1350					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(21)|ovary(4)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	51	all_cancers(71;3.86e-05)|all_epithelial(71;0.000121)|Ovarian(71;0.0412)|all_lung(81;0.0498)|Lung NSC(105;0.0708)|Breast(184;0.127)		OV - Ovarian serous cystadenocarcinoma(106;0.022)			GGAGATGACTCTTTCAACAAA	0.557000													13	19					0	0	0.093190	0	0
DST	667	broad.mit.edu	37	6	56496810	56496810	+	Silent	SNP	G	G	C			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr6:56496810G>C	ENST00000370754.5	-	28	3734	c.3735C>G	c.(3733-3735)ctC>ctG	p.L1245L	DST_ENST00000370769.4_Silent_p.L1067L|DST_ENST00000446842.2_Silent_p.L741L|DST_ENST00000370765.6_Silent_p.L741L|DST_ENST00000312431.6_Silent_p.L1067L|DST_ENST00000361203.3_Silent_p.L1067L|DST_ENST00000518935.1_Silent_p.L741L|DST_ENST00000244364.6_Silent_p.L741L|DST_ENST00000370788.2_Silent_p.L1067L|DST_ENST00000421834.2_Silent_p.L1067L			Q03001	DYST_HUMAN	dystonin	1067					cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			NS(1)|breast(5)|central_nervous_system(8)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(22)|lung(43)|ovary(7)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)	105	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			CAGAGATGTAGAGATTATAAA	0.348000													17	38					0	0	0.160694	0	0
PTPRD	5789	broad.mit.edu	37	9	8484233	8484233	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr9:8484233G>A	ENST00000381196.4	-	27	3842	c.3299C>T	c.(3298-3300)aCg>aTg	p.T1100M	PTPRD_ENST00000537002.1_Missense_Mutation_p.T686M|PTPRD_ENST00000358503.5_Missense_Mutation_p.T1078M|PTPRD_ENST00000486161.1_Missense_Mutation_p.T689M|PTPRD_ENST00000360074.4_Missense_Mutation_p.T1087M|PTPRD_ENST00000356435.5_Missense_Mutation_p.T1100M|PTPRD_ENST00000355233.5_Missense_Mutation_p.T689M|PTPRD_ENST00000397606.3_Missense_Mutation_p.T679M|PTPRD_ENST00000397611.3_Missense_Mutation_p.T686M|PTPRD_ENST00000397617.3_Missense_Mutation_p.T679M|PTPRD_ENST00000540109.1_Missense_Mutation_p.T1100M	NM_002839.3	NP_002830.1	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	1100	Fibronectin type-III 8.				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(7)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|liver(1)|lung(83)|ovary(4)|pancreas(1)|prostate(7)|skin(19)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	168		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		AGTCTTTGCCGTGACCCTGTG	0.483000										TSP Lung(15;0.13)			24	49					0	0	0.083992	0	0
SLTM	79811	broad.mit.edu	37	15	59172279	59172279	+	Silent	SNP	T	T	C			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr15:59172279T>C	ENST00000380516.2	-	21	3111	c.3024A>G	c.(3022-3024)gtA>gtG	p.V1008V	SLTM_ENST00000536328.1_Silent_p.V577V	NM_001013843.1|NM_024755.2	NP_001013865.1|NP_079031.2	Q9NWH9	SLTM_HUMAN	SAFB-like, transcription modulator	1008					apoptosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleotide binding|RNA binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(9)|lung(10)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	28						CACTGATTTGTACAATTCTAT	0.413000													7	55					0	0	0.029380	0	0
NCK2	8440	broad.mit.edu	37	2	106498358	106498358	+	Silent	SNP	A	A	G			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr2:106498358A>G	ENST00000233154.4	+	4	1243	c.801A>G	c.(799-801)ccA>ccG	p.P267P	NCK2_ENST00000451463.2_Intron|NCK2_ENST00000393349.2_Silent_p.P267P|NCK2_ENST00000522586.1_Intron	NM_003581.4	NP_003572.2	O43639	NCK2_HUMAN	NCK adaptor protein 2	267					axon guidance|epidermal growth factor receptor signaling pathway|negative regulation of cell proliferation|positive regulation of actin filament polymerization|positive regulation of T cell proliferation|regulation of epidermal growth factor receptor activity|regulation of translation|signal complex assembly|T cell activation	cytosol|endoplasmic reticulum	cytoskeletal adaptor activity|receptor signaling complex scaffold activity			endometrium(1)|lung(3)|ovary(1)	5						CGCACGCCCCACAGATAAGCT	0.667000													19	32					0	0	0.055883	0	0
PDE11A	50940	broad.mit.edu	37	2	178592823	178592823	+	Silent	SNP	G	G	A			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr2:178592823G>A	ENST00000286063.5	-	11	2183	c.1866C>T	c.(1864-1866)gcC>gcT	p.A622A	PDE11A_ENST00000449286.2_Silent_p.A264A|PDE11A_ENST00000409504.1_Silent_p.A264A|PDE11A_ENST00000358450.4_Silent_p.A372A|PDE11A_ENST00000389683.3_Silent_p.A178A|PDE11A_ENST00000497003.1_5'UTR	NM_016953.3	NP_058649.3	Q9HCR9	PDE11_HUMAN	phosphodiesterase 11A	622					platelet activation|signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|metal ion binding			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(13)|lung(28)|ovary(4)|skin(3)|upper_aerodigestive_tract(3)	58			OV - Ovarian serous cystadenocarcinoma(117;0.00121)|Epithelial(96;0.00455)|all cancers(119;0.02)			CTGTGATCATGGCATCAACGT	0.443000									Primary Pigmented Nodular Adrenocortical Disease, Familial				23	38					0	0	0.091800	0	0
ANK3	288	broad.mit.edu	37	10	61831830	61831830	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr10:61831830C>T	ENST00000280772.1	-	37	9000	c.8809G>A	c.(8809-8811)Gaa>Aaa	p.E2937K	ANK3_ENST00000355288.2_Intron|ANK3_ENST00000503366.1_Intron|ANK3_ENST00000373827.2_Intron	NM_020987.3	NP_066267.2	Q12955	ANK3_HUMAN	ankyrin 3, node of Ranvier (ankyrin G)	2937					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						TGGTCCCCTTCTTTCACAACA	0.443000													14	38					0	0	0.105934	0	0
GALR2	8811	broad.mit.edu	37	17	74072818	74072818	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr17:74072818C>G	ENST00000329003.3	+	2	560	c.470C>G	c.(469-471)tCc>tGc	p.S157C		NM_003857.2	NP_003848.1	O43603	GALR2_HUMAN	galanin receptor 2	157					digestion|elevation of cytosolic calcium ion concentration|feeding behavior|learning or memory|muscle contraction	integral to membrane|plasma membrane	galanin receptor activity			cervix(1)|lung(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	8						CTGCTCTTCTCCGGGCCCTAC	0.692000													14	35					0	0	0.132662	0	0
RYR2	6262	broad.mit.edu	37	1	237713931	237713931	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr1:237713931G>A	ENST00000366574.2	+	27	3471	c.3154G>A	c.(3154-3156)Gag>Aag	p.E1052K	RYR2_ENST00000542537.1_Missense_Mutation_p.E1036K|RYR2_ENST00000360064.6_Missense_Mutation_p.E1050K	NM_001035.2	NP_001026.2	Q92736	RYR2_HUMAN	ryanodine receptor 2 (cardiac)	1052	4 X approximate repeats.|B30.2/SPRY 2.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding	p.E1050K(1)		NS(4)|breast(8)|central_nervous_system(11)|cervix(2)|endometrium(39)|haematopoietic_and_lymphoid_tissue(5)|kidney(17)|large_intestine(83)|liver(4)|lung(353)|ovary(18)|pancreas(5)|prostate(12)|skin(8)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(4)	586	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			CAGCCTCCGCGAGGCTGTGCG	0.493000													6	6					0	0	0.029380	0	0
MVB12B	89853	broad.mit.edu	37	9	129157913	129157913	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr9:129157913C>T	ENST00000361171.3	+	6	680	c.599C>T	c.(598-600)tCa>tTa	p.S200L	MVB12B_ENST00000535766.1_Missense_Mutation_p.S193L|MVB12B_ENST00000436593.3_Missense_Mutation_p.S185L|MVB12B_ENST00000545391.1_Missense_Mutation_p.S200L	NM_033446.2	NP_258257.1			multivesicular body subunit 12B																		AATCATGACTCATCTCAACCC	0.532000													57	91					0	0	0.139131	0	0
DENND2A	27147	broad.mit.edu	37	7	140266910	140266910	+	Missense_Mutation	SNP	T	T	A			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr7:140266910T>A	ENST00000275884.6	-	8	2172	c.1755A>T	c.(1753-1755)gaA>gaT	p.E585D	DENND2A_ENST00000496613.1_Missense_Mutation_p.E585D|DENND2A_ENST00000537639.1_Missense_Mutation_p.E585D|DENND2A_ENST00000492720.1_Missense_Mutation_p.E585D			Q9ULE3	DEN2A_HUMAN	DENN/MADD domain containing 2A	585	UDENN.									breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(22)|ovary(3)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	49	Melanoma(164;0.00956)					GTTGGGTGAGTTCTGGCACGT	0.562000													6	5					0	0	0.029380	0	0
ACOT2	10965	broad.mit.edu	37	14	74040259	74040259	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr14:74040259G>A	ENST00000238651.5	+	2	993	c.811G>A	c.(811-813)Gaa>Aaa	p.E271K	ACOT2_ENST00000538782.1_Missense_Mutation_p.E74K	NM_006821.5	NP_006812.3	P49753	ACOT2_HUMAN	acyl-CoA thioesterase 2	271					acyl-CoA metabolic process|long-chain fatty acid metabolic process|very long-chain fatty acid metabolic process	mitochondrion	carboxylesterase activity|palmitoyl-CoA hydrolase activity|protein binding			breast(1)|kidney(1)|large_intestine(1)|lung(6)|prostate(2)|skin(1)|urinary_tract(1)	13				BRCA - Breast invasive adenocarcinoma(234;0.0033)|OV - Ovarian serous cystadenocarcinoma(108;0.0639)		GGAGTACTTTGAAGAAGCCAT	0.453000													62	89					0	0	0.139131	0	0
TP53I3	9540	broad.mit.edu	37	2	24302332	24302332	+	Silent	SNP	C	C	T			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr2:24302332C>T	ENST00000238721.4	-	4	1652	c.798G>A	c.(796-798)ctG>ctA	p.L266L	TP53I3_ENST00000335934.4_Silent_p.L266L|TP53I3_ENST00000313482.4_Intron|TP53I3_ENST00000407482.1_Intron|FAM228B_ENST00000461972.1_Intron	NM_004881.4	NP_004872.2	Q53FA7	QORX_HUMAN	tumor protein p53 inducible protein 3	266					induction of apoptosis by oxidative stress|NADP metabolic process		NADPH binding|NADPH:quinone reductase activity|protein homodimerization activity|quinone binding|zinc ion binding			endometrium(1)|kidney(4)|large_intestine(2)|lung(3)|urinary_tract(2)	12	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CCCTAGACCTCAGCAAACTGG	0.438000													35	90					0	0	0.080422	0	0
LY9	4063	broad.mit.edu	37	1	160771628	160771628	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr1:160771628G>A	ENST00000368039.2	+	3	504	c.503G>A	c.(502-504)cGc>cAc	p.R168H	LY9_ENST00000263285.5_Intron|LY9_ENST00000368040.1_Intron|LY9_ENST00000368041.2_Intron|LY9_ENST00000471816.1_Intron|LY9_ENST00000341032.4_Intron	NM_001033667.2	NP_001028839.1	Q9HBG7	LY9_HUMAN	lymphocyte antigen 9	0	Ig-like C2-type 1.				cell adhesion|immunoglobulin mediated immune response	integral to membrane		p.R168H(1)		autonomic_ganglia(1)|breast(1)|endometrium(4)|kidney(3)|large_intestine(5)|lung(17)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	36	all_cancers(52;2.72e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00737)			GGTGACCACCGCACACTCCTG	0.572000													4	148					0	0	0.150653	0	0
DOK1	1796	broad.mit.edu	37	2	74784055	74784055	+	Silent	SNP	C	C	A			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr2:74784055C>A	ENST00000233668.5	+	5	1929	c.1260C>A	c.(1258-1260)ctC>ctA	p.L420L	DOK1_ENST00000409429.1_Silent_p.L281L|DOK1_ENST00000340004.6_3'UTR|DOK1_ENST00000480318.1_3'UTR	NM_001381.3	NP_001372.1	Q99704	DOK1_HUMAN	docking protein 1, 62kDa (downstream of tyrosine kinase 1)	420	Pro-rich.				fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway	cytosol|perinuclear region of cytoplasm	insulin receptor binding			endometrium(3)|large_intestine(2)|liver(2)|lung(6)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	16						CAAAGCCCCTCCTTGCTCCCA	0.617000													81	147					3.16549e-35	3.49015e-35	0.139131	1	0
KIAA2026	158358	broad.mit.edu	37	9	5968206	5968206	+	Silent	SNP	G	G	A			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr9:5968206G>A	ENST00000399933.3	-	3	2024	c.2025C>T	c.(2023-2025)ctC>ctT	p.L675L	KIAA2026_ENST00000381461.2_Silent_p.L675L	NM_001017969.2	NP_001017969.2	Q5HYC2	K2026_HUMAN	KIAA2026	675	Lys-rich.									breast(6)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(11)|lung(15)|ovary(2)|prostate(2)|skin(1)	46		Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.00155)|Lung(218;0.124)		TAGTTAGTTTGAGTTTCTTGT	0.333000													23	41					0	0	0.076483	0	0
CTSS	1520	broad.mit.edu	37	1	150724308	150724308	+	Silent	SNP	G	G	A			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr1:150724308G>A	ENST00000368985.3	-	5	836	c.576C>T	c.(574-576)atC>atT	p.I192I	CTSS_ENST00000480760.1_5'UTR|CTSS_ENST00000448301.2_Silent_p.I142I	NM_001199739.1|NM_004079.4	NP_001186668.1|NP_004070.3	P25774	CATS_HUMAN	cathepsin S	192					immune response|proteolysis	extracellular region|lysosome	cysteine-type endopeptidase activity			cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(5)|skin(1)|stomach(1)|urinary_tract(1)	15	all_cancers(9;6.17e-52)|all_epithelial(9;9.7e-43)|all_lung(15;5.74e-35)|Lung NSC(24;2.09e-31)|Breast(34;0.00146)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Melanoma(130;0.128)|Colorectal(459;0.171)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0485)|Epithelial(6;5.02e-21)|all cancers(9;1.28e-20)|OV - Ovarian serous cystadenocarcinoma(6;1.09e-14)|BRCA - Breast invasive adenocarcinoma(12;0.00501)|LUSC - Lung squamous cell carcinoma(543;0.171)			TGTTATCAATGATGTACTGGA	0.468000													48	88					0	0	0.139131	0	0
CAMSAP3	57662	broad.mit.edu	37	19	7677766	7677766	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr19:7677766G>A	ENST00000446248.2	+	13	2569	c.2468G>A	c.(2467-2469)aGg>aAg	p.R823K	CAMSAP3_ENST00000160298.4_Missense_Mutation_p.R796K	NM_001080429.2	NP_001073898.1	Q9P1Y5	CAMP3_HUMAN	calmodulin regulated spectrin-associated protein family, member 3	796	Pro-rich.				epithelial cell-cell adhesion|microtubule anchoring|regulation of microtubule cytoskeleton organization|zonula adherens maintenance	cytoplasm|microtubule|zonula adherens	microtubule minus-end binding			cervix(1)|endometrium(7)|kidney(3)|lung(6)|urinary_tract(2)	19						CCCTTGACCAGGGTGCTTACG	0.726000													3	8					0	0	0.115264	0	0
SLC12A8	84561	broad.mit.edu	37	3	124839586	124839586	+	Silent	SNP	C	C	A			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr3:124839586C>A	ENST00000430155.2	-	1	112	c.84G>T	c.(82-84)ggG>ggT	p.G28G	SLC12A8_ENST00000423114.2_Intron|SLC12A8_ENST00000465475.1_Intron|SLC12A8_ENST00000393469.4_Intron|SLC12A8_ENST00000314584.7_Intron|SLC12A8_ENST00000469902.1_Intron			A0AV02	S12A8_HUMAN	solute carrier family 12, member 8	0					potassium ion transport	integral to membrane	symporter activity			endometrium(2)|kidney(2)|lung(12)	16						GCATCGCCTTCCCCAGGGCTG	0.637000													8	7					3.09899e-07	3.211e-07	0.047766	1	0
NFATC1	4772	broad.mit.edu	37	18	77208872	77208872	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr18:77208872C>T	ENST00000253506.5	+	4	1846	c.1477C>T	c.(1477-1479)Cag>Tag	p.Q493*	NFATC1_ENST00000545796.1_Nonsense_Mutation_p.Q21*|NFATC1_ENST00000542384.1_Nonsense_Mutation_p.Q493*|NFATC1_ENST00000397790.2_Nonsense_Mutation_p.Q21*|NFATC1_ENST00000329101.4_Nonsense_Mutation_p.Q480*|NFATC1_ENST00000427363.2_Nonsense_Mutation_p.Q493*|NFATC1_ENST00000318065.5_Nonsense_Mutation_p.Q480*|NFATC1_ENST00000587635.1_Nonsense_Mutation_p.Q493*|NFATC1_ENST00000592223.1_Nonsense_Mutation_p.Q480*|NFATC1_ENST00000591814.1_Nonsense_Mutation_p.Q493*|NFATC1_ENST00000586434.1_Nonsense_Mutation_p.Q480*	NM_006162.3	NP_006153.2	O95644	NFAC1_HUMAN	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1	493	RHD.				intracellular signal transduction|positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|nucleus	FK506 binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			NS(2)|breast(1)|endometrium(7)|kidney(1)|large_intestine(4)|lung(17)|ovary(2)|prostate(4)|skin(1)|soft_tissue(1)	40		Esophageal squamous(42;0.0157)|Melanoma(33;0.144)		OV - Ovarian serous cystadenocarcinoma(15;3.73e-07)|BRCA - Breast invasive adenocarcinoma(31;0.0257)		CGCCTTCTACCAGGTGCACCG	0.622000													18	13					0	0	0.175082	0	0
RPE	6120	broad.mit.edu	37	2	210867428	210867428	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr2:210867428G>A	ENST00000359429.6	+	1	140	c.43G>A	c.(43-45)Gac>Aac	p.D15N	RPE_ENST00000454822.1_5'UTR|RPE_ENST00000438204.2_5'UTR|RPE_ENST00000429907.1_5'UTR|RPE_ENST00000436630.2_5'UTR|RPE_ENST00000429921.1_5'UTR|RPE_ENST00000411934.2_5'UTR|RPE_ENST00000354506.6_Missense_Mutation_p.D15N|RPE_ENST00000540255.1_Missense_Mutation_p.D15N|RPE_ENST00000435437.2_Missense_Mutation_p.D15N|RPE_ENST00000452025.1_Missense_Mutation_p.D15N|RPE_ENST00000445268.1_5'UTR	NM_199229.1	NP_954699.1	Q96AT9	RPE_HUMAN	ribulose-5-phosphate-3-epimerase	15					pentose-phosphate shunt	cytosol	metal ion binding|protein homodimerization activity|ribulose-phosphate 3-epimerase activity			endometrium(1)|kidney(1)|large_intestine(2)|lung(3)|skin(2)	9				Epithelial(149;0.00241)|Lung(261;0.041)|all cancers(144;0.0429)|LUSC - Lung squamous cell carcinoma(261;0.0431)		CCTCAACAGCGACCTGGCCAA	0.617000													16	34					0	0	0.132662	0	0
POT1	25913	broad.mit.edu	37	7	124481048	124481048	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr7:124481048C>T	ENST00000357628.3	-	14	1946	c.1348G>A	c.(1348-1350)Gaa>Aaa	p.E450K	POT1_ENST00000393329.1_Missense_Mutation_p.E319K	NM_015450.2	NP_056265.2	Q9NUX5	POTE1_HUMAN	protection of telomeres 1	450					DNA duplex unwinding|negative regulation of telomere maintenance via telomerase|positive regulation of DNA strand elongation|positive regulation of helicase activity|positive regulation of telomerase activity|positive regulation of telomere maintenance via telomerase|telomere capping|telomere formation via telomerase|telomere maintenance via telomerase	nuclear telomere cap complex|nucleoplasm	DEAD/H-box RNA helicase binding|single-stranded telomeric DNA binding|telomerase inhibitor activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(4)|liver(1)|lung(23)|ovary(1)|prostate(1)|skin(3)|stomach(1)|urinary_tract(1)	47						AGTAGACATTCATTTGAAAGC	0.269000													30	77					0	0	0.163468	0	0
UNC5D	137970	broad.mit.edu	37	8	35616853	35616853	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr8:35616853G>A	ENST00000287272.2	+	13	1992	c.1972G>A	c.(1972-1974)Gaa>Aaa	p.E658K	UNC5D_ENST00000420357.1_Missense_Mutation_p.E660K|UNC5D_ENST00000416672.1_Missense_Mutation_p.E732K|UNC5D_ENST00000453357.2_Missense_Mutation_p.E722K|UNC5D_ENST00000404895.2_Missense_Mutation_p.E727K|UNC5D_ENST00000449677.1_Missense_Mutation_p.E303K			Q6UXZ4	UNC5D_HUMAN	unc-5 homolog D (C. elegans)	727					apoptosis|axon guidance	integral to membrane	receptor activity			NS(2)|breast(7)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(14)|lung(56)|ovary(3)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(6)|urinary_tract(2)	112				READ - Rectum adenocarcinoma(1;1.31e-05)|Colorectal(1;0.000723)		GGTTTCAGATGAAAGGCATCA	0.378000													37	70					0	0	0.069456	0	0
HERC1	8925	broad.mit.edu	37	15	64026927	64026927	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr15:64026927C>A	ENST00000443617.2	-	13	2729	c.2642G>T	c.(2641-2643)gGa>gTa	p.G881V		NM_003922.3	NP_003913.3	Q15751	HERC1_HUMAN	HECT and RLD domain containing E3 ubiquitin protein ligase family member 1	881					protein modification process|transport	cytosol|Golgi apparatus|membrane	acid-amino acid ligase activity|ARF guanyl-nucleotide exchange factor activity			NS(3)|breast(9)|central_nervous_system(4)|endometrium(23)|haematopoietic_and_lymphoid_tissue(1)|kidney(12)|large_intestine(22)|liver(1)|lung(36)|ovary(7)|prostate(4)|skin(3)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	132						GCCTACCTGTCCTTTAGATAA	0.403000													25	49					7.76418e-22	8.45215e-22	0.108266	1	0
MARCH7	64844	broad.mit.edu	37	2	160615841	160615841	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr2:160615841G>A	ENST00000259050.3	+	7	2010	c.1888G>A	c.(1888-1890)Gaa>Aaa	p.E630K	MARCH7_ENST00000409175.1_Missense_Mutation_p.E630K|MARCH7_ENST00000409591.1_Missense_Mutation_p.E592K|MARCH7_ENST00000539065.1_Missense_Mutation_p.E574K	NM_022826.2	NP_073737.1	Q9H992	MARH7_HUMAN	membrane-associated ring finger (C3HC4) 7, E3 ubiquitin protein ligase	630							ligase activity|zinc ion binding			breast(1)|endometrium(2)|kidney(3)|large_intestine(5)|lung(3)|prostate(1)|skin(1)|stomach(2)	18						TCATGCAAATGAACAAGTTAG	0.353000													38	57					0	0	0.098360	0	0
LOC100288069	100288069	broad.mit.edu	37	1	700532	700532	+	RNA	DEL	T	T	-			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr1:700532delT	ENST00000428504.1	-	0	1021					NR_033908.1																						aaaaaaaaaaTTCCTTTGGGA	0.453													3	4	---	---	---	---					
ARID5A	10865	broad.mit.edu	37	2	97215191	97215195	+	Splice_Site	DEL	AGCAG	AGCAG	-			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr2:97215191_97215195delAGCAG	ENST00000454558.2	+	3	1227_1231	c.55_splice	c.e3+1	p.KQ17_splice	ARID5A_ENST00000357485.3_Splice_Site_p.KQ85_splice			Q03989	ARI5A_HUMAN	AT rich interactive domain 5A (MRF1-like)	85					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus	DNA binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(6)|prostate(2)|skin(1)|urinary_tract(2)	14						CTCGGCTTCAAGCAGAGTGCGTCCC	0.678													21	54	---	---	---	---					
FBLL1	345630	broad.mit.edu	37	5	167956924	167956924	+	Frame_Shift_Del	DEL	G	G	-			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr5:167956924delG	ENST00000338333.4	+	1	804	c.415delG	c.(415-417)agfs	p.E139fs																								CACGGTGACCGAGGGCGGCGT	0.677													2	4	---	---	---	---					
ANKRD13A	88455	broad.mit.edu	37	12	110463612	110463618	+	Frame_Shift_Del	DEL	AAAAAAG	AAAAAAG	-			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr12:110463612_110463618delAAAAAAG	ENST00000261739.4	+	8	1033_1039	c.867_873delAAAAAAG	c.(865-873)gafs	p.EKK289fs		NM_033121.1	NP_149112.1	Q8IZ07	AN13A_HUMAN	ankyrin repeat domain 13A	289										endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(8)|lung(3)|urinary_tract(1)	16						CCGAGGAGGAAAAAAAGAGATATAAAG	0.406													12	92	---	---	---	---					
DNM1P47	100216544	broad.mit.edu	37	15	102299886	102299887	+	RNA	INS	-	-	G			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr15:102299886_102299887insG	ENST00000561463.1	+	0	7932_7933																											AACCTGTACTCGCGTCGGAACC	0.589													3	5	---	---	---	---					
SLC1A5	6510	broad.mit.edu	37	19	47282157	47282157	+	Frame_Shift_Del	DEL	G	G	-			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr19:47282157delG	ENST00000542575.2	-	5	1461	c.833delC	c.(832-834)ctfs	p.P278fs	SLC1A5_ENST00000434726.2_Frame_Shift_Del_p.P76fs|SLC1A5_ENST00000412532.2_Frame_Shift_Del_p.P50fs|SLC1A5_ENST00000594991.1_Frame_Shift_Del_p.P102fs	NM_005628.2	NP_005619.1	Q15758	AAAT_HUMAN	solute carrier family 1 (neutral amino acid transporter), member 5	278					cellular nitrogen compound metabolic process	integral to plasma membrane|melanosome|membrane fraction	neutral amino acid transmembrane transporter activity|protein binding|receptor activity|sodium:dicarboxylate symporter activity			cervix(1)|endometrium(3)|kidney(3)|large_intestine(3)|lung(2)|stomach(1)	13		all_epithelial(76;0.00314)|Ovarian(192;0.0798)|all_neural(266;0.107)		OV - Ovarian serous cystadenocarcinoma(262;0.000338)|all cancers(93;0.000882)|Epithelial(262;0.0211)|GBM - Glioblastoma multiforme(486;0.0341)	L-Asparagine(DB00174)|L-Glutamine(DB00130)	GATGCCCACAGGGGCGTACCT	0.582													15	27	---	---	---	---					
TPTEP1	387590	broad.mit.edu	37	22	17127506	17127507	+	RNA	INS	-	-	A			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr22:17127506_17127507insA	ENST00000426585.1	+	0	442																											AGGGCCTAGAGAAAAAAAAAAT	0.421													7	87	---	---	---	---