Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
SPAG17	200162	broad.mit.edu	37	1	118512703	118512703	+	Silent	SNP	C	C	T			TCGA-D6-A6EN-01A-11D-A31L-08	TCGA-D6-A6EN-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	971ca2bc-cd7b-4ce1-a471-81445b85e3a4	20f2c75b-d578-4332-83cb-0e2307d84fff	g.chr1:118512703C>T	ENST00000336338.5	-	46	6428	c.6363G>A	c.(6361-6363)ctG>ctA	p.L2121L		NM_206996.2	NP_996879.1	Q6Q759	SPG17_HUMAN	sperm associated antigen 17	2121						cilium|flagellar axoneme|microtubule				NS(1)|biliary_tract(1)|breast(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(30)|liver(2)|lung(56)|ovary(3)|prostate(5)|skin(5)|upper_aerodigestive_tract(6)|urinary_tract(1)	123	Esophageal squamous(2;0.0106)	all_cancers(81;0.0204)|all_lung(203;9.46e-05)|Lung NSC(69;0.000675)|all_epithelial(167;0.01)		Lung(183;0.0858)		AAGTCACTTTCAGTCCTGTGC	0.413000													9	34					0	0	1	0	0
TTBK1	84630	broad.mit.edu	37	6	43222821	43222821	+	Missense_Mutation	SNP	G	G	A			TCGA-D6-A6EN-01A-11D-A31L-08	TCGA-D6-A6EN-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	971ca2bc-cd7b-4ce1-a471-81445b85e3a4	20f2c75b-d578-4332-83cb-0e2307d84fff	g.chr6:43222821G>A	ENST00000259750.4	+	7	694	c.611G>A	c.(610-612)cGc>cAc	p.R204H	TTBK1_ENST00000304139.5_Missense_Mutation_p.R153H	NM_032538.1	NP_115927.1	Q5TCY1	TTBK1_HUMAN	tau tubulin kinase 1	204	Protein kinase.					cell junction|cytoplasm|nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			breast(2)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(10)|liver(1)|lung(21)|ovary(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	53			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0125)|OV - Ovarian serous cystadenocarcinoma(102;0.0399)			GGAACGGTTCGCTATGCCTCA	0.617000													12	38					0	0	1	0	0
DCAF12L2	340578	broad.mit.edu	37	X	125299869	125299869	+	Silent	SNP	C	C	A			TCGA-D6-A6EN-01A-11D-A31L-08	TCGA-D6-A6EN-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	971ca2bc-cd7b-4ce1-a471-81445b85e3a4	20f2c75b-d578-4332-83cb-0e2307d84fff	g.chrX:125299869C>A	ENST00000538699.1	-	2	119	c.39G>T	c.(37-39)gcG>gcT	p.A13A	DCAF12L2_ENST00000360028.2_Silent_p.A13A	NM_001013628.2	NP_001013650.1	Q5VW00	DC122_HUMAN	DDB1 and CUL4 associated factor 12-like 2	13										NS(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(11)|lung(36)|ovary(2)|pancreas(1)|skin(2)|upper_aerodigestive_tract(3)	64						CGACCGCGGGCGCTTTCCGTT	0.751000													4	11					0.000602214	0.000619298	1	1	0
COL4A3BP	10087	broad.mit.edu	37	5	74695169	74695169	+	Missense_Mutation	SNP	C	C	T			TCGA-D6-A6EN-01A-11D-A31L-08	TCGA-D6-A6EN-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	971ca2bc-cd7b-4ce1-a471-81445b85e3a4	20f2c75b-d578-4332-83cb-0e2307d84fff	g.chr5:74695169C>T	ENST00000380494.5	-	12	1831	c.1538G>A	c.(1537-1539)aGt>aAt	p.S513N	COL4A3BP_ENST00000261415.7_Intron|COL4A3BP_ENST00000405807.4_Missense_Mutation_p.S385N	NM_001130105.1	NP_001123577.1	Q9Y5P4	C43BP_HUMAN	collagen, type IV, alpha 3 (Goodpasture antigen) binding protein	385	START.				ER to Golgi ceramide transport|immune response	cytosol|endoplasmic reticulum membrane|Golgi apparatus	ceramide binding|phosphatidylinositol-4-phosphate binding|protein binding|protein kinase activity			breast(1)|kidney(1)|large_intestine(5)|lung(4)|skin(3)|stomach(1)|urinary_tract(1)	16		all_lung(232;0.00101)|Lung NSC(167;0.00278)|Ovarian(174;0.0129)|Prostate(461;0.174)		OV - Ovarian serous cystadenocarcinoma(47;1e-53)		ATCAGAGGCACTGACTAGATC	0.438000													9	31					0	0	1	0	0
HRAS	3265	broad.mit.edu	37	11	533874	533874	+	Missense_Mutation	SNP	T	T	A	rs121913233		TCGA-D6-A6EN-01A-11D-A31L-08	TCGA-D6-A6EN-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	971ca2bc-cd7b-4ce1-a471-81445b85e3a4	20f2c75b-d578-4332-83cb-0e2307d84fff	g.chr11:533874T>A	ENST00000417302.1	-	3	369	c.182A>T	c.(181-183)cAg>cTg	p.Q61L	HRAS_ENST00000468682.2_5'UTR|HRAS_ENST00000397594.1_Missense_Mutation_p.Q61L|HRAS_ENST00000451590.1_Missense_Mutation_p.Q61L|HRAS_ENST00000397596.2_Missense_Mutation_p.Q61L|HRAS_ENST00000311189.7_Missense_Mutation_p.Q61L	NM_176795.3	NP_789765.1	P01112	RASH_HUMAN	Harvey rat sarcoma viral oncogene homolog	61			Q -> K (in follicular thyroid carcinoma samples; somatic mutation; increases transformation of cultured cell lines; dbSNP:rs28933406).|Q -> L (in melanoma; strongly reduced GTP hydrolysis in the presence of RAF1; increases transformation of cultured cell lines).		activation of MAPKK activity|axon guidance|blood coagulation|cell cycle arrest|cellular senescence|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|mitotic cell cycle G1/S transition checkpoint|negative regulation of cell proliferation|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of DNA replication|positive regulation of epithelial cell proliferation|Ras protein signal transduction|synaptic transmission	cytosol|Golgi membrane|plasma membrane	GTP binding|GTPase activity|protein C-terminus binding	p.Q61R(136)|p.Q61L(117)|p.Q61P(3)		adrenal_gland(1)|bone(3)|breast(7)|cervix(23)|endometrium(4)|haematopoietic_and_lymphoid_tissue(12)|kidney(1)|large_intestine(2)|liver(1)|lung(16)|oesophagus(2)|penis(2)|pituitary(10)|prostate(31)|salivary_gland(24)|skin(184)|soft_tissue(38)|stomach(14)|testis(5)|thymus(1)|thyroid(173)|upper_aerodigestive_tract(122)|urinary_tract(225)	901		all_cancers(49;4.37e-09)|all_epithelial(84;2.09e-06)|Breast(177;0.000162)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.0538)|all_lung(207;0.0713)		all cancers(45;7.63e-28)|Epithelial(43;7.29e-27)|OV - Ovarian serous cystadenocarcinoma(40;7.15e-21)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0375)|LUSC - Lung squamous cell carcinoma(625;0.0703)	Sulindac(DB00605)	GTACTCCTCCTGGCCGGCGGT	0.597000	Q61L(KNS62_LUNG)|Q61L(KYSE30_OESOPHAGUS)|Q61L(NCIH1915_LUNG)	6	Mis		"""infrequent sarcomas, rare other types"""	"""rhadomyosarcoma, ganglioneuroblastoma, bladder"""			Costello syndrome	HNSCC(11;0.0054)			34	85					0	0	1	0	0
GRHL3	57822	broad.mit.edu	37	1	24663185	24663185	+	Silent	SNP	G	G	A	rs144195527		TCGA-D6-A6EN-01A-11D-A31L-08	TCGA-D6-A6EN-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	971ca2bc-cd7b-4ce1-a471-81445b85e3a4	20f2c75b-d578-4332-83cb-0e2307d84fff	g.chr1:24663185G>A	ENST00000361548.4	+	4	710	c.480G>A	c.(478-480)gtG>gtA	p.V160V	GRHL3_ENST00000356046.2_Silent_p.V114V|GRHL3_ENST00000350501.5_Silent_p.V160V|GRHL3_ENST00000530984.1_3'UTR|GRHL3_ENST00000342072.4_Silent_p.V67V|GRHL3_ENST00000236255.4_Silent_p.V165V	NM_198173.2	NP_937816.1	Q8TE85	GRHL3_HUMAN	grainyhead-like 3 (Drosophila)	160			V -> A (in dbSNP:rs34637004).		regulation of actin cytoskeleton organization|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)|pancreas(3)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	20		Colorectal(325;3.46e-05)|Renal(390;0.0007)|Lung NSC(340;0.00171)|all_lung(284;0.00226)|Ovarian(437;0.00348)|Breast(348;0.0126)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.19)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;8.72e-25)|Colorectal(126;4.38e-08)|COAD - Colon adenocarcinoma(152;1.84e-06)|GBM - Glioblastoma multiforme(114;0.000132)|BRCA - Breast invasive adenocarcinoma(304;0.00105)|STAD - Stomach adenocarcinoma(196;0.00151)|KIRC - Kidney renal clear cell carcinoma(1967;0.00377)|READ - Rectum adenocarcinoma(331;0.0656)|Lung(427;0.143)		CCGGCTCTGTGGACAGCTACC	0.592000													35	93					0	0	1	0	0
IRF2	3660	broad.mit.edu	37	4	185310172	185310172	+	Missense_Mutation	SNP	T	T	C			TCGA-D6-A6EN-01A-11D-A31L-08	TCGA-D6-A6EN-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	971ca2bc-cd7b-4ce1-a471-81445b85e3a4	20f2c75b-d578-4332-83cb-0e2307d84fff	g.chr4:185310172T>C	ENST00000393593.3	-	9	997	c.790A>G	c.(790-792)Agc>Ggc	p.S264G		NM_002199.3	NP_002190.2	P14316	IRF2_HUMAN	interferon regulatory factor 2	264					blood coagulation|cell proliferation|interferon-gamma-mediated signaling pathway|negative regulation of transcription from RNA polymerase II promoter|type I interferon-mediated signaling pathway	focal adhesion|nucleoplasm	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			cervix(1)|endometrium(2)|kidney(1)|large_intestine(4)|liver(2)|lung(3)|ovary(2)|prostate(1)|skin(3)|stomach(1)|urinary_tract(2)	22		all_lung(41;7.86e-14)|Lung NSC(41;1.87e-13)|Colorectal(36;0.00146)|Hepatocellular(41;0.00826)|Renal(120;0.00992)|Prostate(90;0.0115)|all_neural(102;0.0573)|all_hematologic(60;0.0592)		all cancers(43;3.94e-27)|Epithelial(43;5.3e-24)|OV - Ovarian serous cystadenocarcinoma(60;1.06e-10)|Colorectal(24;7.98e-07)|STAD - Stomach adenocarcinoma(60;3.95e-05)|GBM - Glioblastoma multiforme(59;8.3e-05)|COAD - Colon adenocarcinoma(29;0.000106)|BRCA - Breast invasive adenocarcinoma(30;0.000311)|LUSC - Lung squamous cell carcinoma(40;0.0128)|READ - Rectum adenocarcinoma(43;0.0419)		CCCATGTTGCTGAGGTACTGT	0.512000													34	155					0	0	1	0	0
NCKAP5	344148	broad.mit.edu	37	2	133542417	133542417	+	Missense_Mutation	SNP	C	C	T			TCGA-D6-A6EN-01A-11D-A31L-08	TCGA-D6-A6EN-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	971ca2bc-cd7b-4ce1-a471-81445b85e3a4	20f2c75b-d578-4332-83cb-0e2307d84fff	g.chr2:133542417C>T	ENST00000409261.1	-	14	2340	c.1967G>A	c.(1966-1968)aGa>aAa	p.R656K	NCKAP5_ENST00000317721.6_Missense_Mutation_p.R656K|NCKAP5_ENST00000409213.1_Intron|NCKAP5_ENST00000405974.3_Intron	NM_207363.2	NP_997246.2	O14513	NCKP5_HUMAN	NCK-associated protein 5	656							protein binding			NS(4)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(29)|lung(51)|prostate(5)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	118						TTTTACAACTCTTTGCTGCTT	0.438000													18	35					0	0	1	0	0
HSPA14	51182	broad.mit.edu	37	10	14909272	14909272	+	Nonsense_Mutation	SNP	C	C	G			TCGA-D6-A6EN-01A-11D-A31L-08	TCGA-D6-A6EN-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	971ca2bc-cd7b-4ce1-a471-81445b85e3a4	20f2c75b-d578-4332-83cb-0e2307d84fff	g.chr10:14909272C>G	ENST00000378372.3	+	11	1423	c.1184C>G	c.(1183-1185)tCa>tGa	p.S395*		NM_016299.2	NP_057383.2	Q0VDF9	HSP7E_HUMAN	heat shock 70kDa protein 14	395					'de novo' cotranslational protein folding	cytosol	ATP binding|protein binding			breast(4)|endometrium(2)|kidney(2)|large_intestine(3)|lung(4)|ovary(2)	17						ATAGAGTGTTCAGCCAGAGAT	0.343000													6	44					0	0	1	0	0
CASP8	841	broad.mit.edu	37	2	202131229	202131229	+	Missense_Mutation	SNP	T	T	G			TCGA-D6-A6EN-01A-11D-A31L-08	TCGA-D6-A6EN-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	971ca2bc-cd7b-4ce1-a471-81445b85e3a4	20f2c75b-d578-4332-83cb-0e2307d84fff	g.chr2:202131229T>G	ENST00000358485.4	+	2	393	c.197T>G	c.(196-198)cTt>cGt	p.L66R	CASP8_ENST00000323492.7_Missense_Mutation_p.L7R|CASP8_ENST00000392259.2_Missense_Mutation_p.L7R|CASP8_ENST00000392258.3_Missense_Mutation_p.L7R|CASP8_ENST00000432109.2_Missense_Mutation_p.L7R|CASP8_ENST00000392266.3_Missense_Mutation_p.L7R|CASP8_ENST00000264274.9_Missense_Mutation_p.L7R|CASP8_ENST00000264275.5_Missense_Mutation_p.L7R	NM_001080125.1	NP_001073594.1	Q14790	CASP8_HUMAN	caspase 8, apoptosis-related cysteine peptidase	7	DED 1.				activation of caspase activity|activation of pro-apoptotic gene products|cellular component disassembly involved in apoptosis|cellular response to mechanical stimulus|induction of apoptosis by extracellular signals|induction of apoptosis by intracellular signals|positive regulation of I-kappaB kinase/NF-kappaB cascade|proteolysis involved in cellular protein catabolic process|response to tumor necrosis factor	centrosome|cytosol|mitochondrial outer membrane	cysteine-type endopeptidase activity|protein binding			breast(5)|cervix(2)|endometrium(6)|large_intestine(11)|lung(10)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(9)|urinary_tract(3)	52						AGCAGAAATCTTTATGATATT	0.408000										HNSCC(4;0.00038)			19	48					0	0	1	0	0
C10orf111	221060	broad.mit.edu	37	10	15138578	15138578	+	Silent	SNP	C	C	G			TCGA-D6-A6EN-01A-11D-A31L-08	TCGA-D6-A6EN-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	971ca2bc-cd7b-4ce1-a471-81445b85e3a4	20f2c75b-d578-4332-83cb-0e2307d84fff	g.chr10:15138578C>G	ENST00000378207.3	-	2	519	c.246G>C	c.(244-246)gtG>gtC	p.V82V		NM_153244.1	NP_694976.1	Q8N326	CJ111_HUMAN	chromosome 10 open reading frame 111	82						integral to membrane				lung(5)|upper_aerodigestive_tract(1)	6						GCCGCTTCATCACTTGTCCCC	0.507000													25	65					0	0	1	0	0
COL1A2	1278	broad.mit.edu	37	7	94057708	94057708	+	Missense_Mutation	SNP	C	C	A			TCGA-D6-A6EN-01A-11D-A31L-08	TCGA-D6-A6EN-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	971ca2bc-cd7b-4ce1-a471-81445b85e3a4	20f2c75b-d578-4332-83cb-0e2307d84fff	g.chr7:94057708C>A	ENST00000297268.6	+	50	4101	c.3630C>A	c.(3628-3630)aaC>aaA	p.N1210K		NM_000089.3	NP_000080.2	P08123	CO1A2_HUMAN	collagen, type I, alpha 2	1210	Fibrillar collagen NC1.				axon guidance|blood vessel development|collagen fibril organization|leukocyte migration|odontogenesis|platelet activation|regulation of blood pressure|Rho protein signal transduction|skeletal system development|skin morphogenesis|transforming growth factor beta receptor signaling pathway	collagen type I|extracellular space|plasma membrane	extracellular matrix structural constituent|identical protein binding|platelet-derived growth factor binding|protein binding, bridging		COL1A2/PLAG1(3)	NS(2)|breast(2)|central_nervous_system(4)|cervix(1)|endometrium(6)|kidney(8)|large_intestine(21)|lung(51)|ovary(2)|prostate(1)|skin(7)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(1)	115	all_cancers(62;2.46e-09)|all_epithelial(64;2.7e-08)		STAD - Stomach adenocarcinoma(171;0.0031)		Collagenase(DB00048)	AACCTGAAAACATCCCAGCCA	0.478000										HNSCC(75;0.22)			26	46					1.66031e-10	1.82382e-10	1	1	0
NEB	4703	broad.mit.edu	37	2	152518695	152518695	+	Missense_Mutation	SNP	G	G	A			TCGA-D6-A6EN-01A-11D-A31L-08	TCGA-D6-A6EN-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	971ca2bc-cd7b-4ce1-a471-81445b85e3a4	20f2c75b-d578-4332-83cb-0e2307d84fff	g.chr2:152518695G>A	ENST00000397345.3	-	46	6126	c.5924C>T	c.(5923-5925)tCg>tTg	p.S1975L	NEB_ENST00000427231.2_Missense_Mutation_p.S1975L|NEB_ENST00000603639.1_Missense_Mutation_p.S1975L|NEB_ENST00000604864.1_Missense_Mutation_p.S1975L|NEB_ENST00000172853.10_Missense_Mutation_p.S1975L|NEB_ENST00000409198.1_Missense_Mutation_p.S1975L	NM_001164508.1	NP_001157980.1	P20929	NEBU_HUMAN	nebulin	1975					muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			NS(5)|autonomic_ganglia(3)|breast(9)|central_nervous_system(5)|cervix(3)|endometrium(35)|kidney(16)|large_intestine(77)|liver(1)|lung(99)|ovary(9)|pancreas(3)|prostate(13)|skin(7)|stomach(8)|upper_aerodigestive_tract(6)|urinary_tract(2)	301				BRCA - Breast invasive adenocarcinoma(221;0.219)		CATGTTCATCGAGTCCATGAG	0.398000													15	30					0	0	1	0	0
PCDHGB7	56099	broad.mit.edu	37	5	140799002	140799002	+	Missense_Mutation	SNP	C	C	A			TCGA-D6-A6EN-01A-11D-A31L-08	TCGA-D6-A6EN-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	971ca2bc-cd7b-4ce1-a471-81445b85e3a4	20f2c75b-d578-4332-83cb-0e2307d84fff	g.chr5:140799002C>A	ENST00000398594.2	+	1	1576	c.1576C>A	c.(1576-1578)Cgc>Agc	p.R526S	PCDHGA10_ENST00000398610.2_Intron|PCDHGA8_ENST00000398604.2_Intron|PCDHGB3_ENST00000576222.1_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGB4_ENST00000519479.1_Intron|PCDHGA7_ENST00000518325.1_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGA6_ENST00000517434.1_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA9_ENST00000573521.1_Intron|PCDHGB6_ENST00000520790.1_Intron	NM_018927.3	NP_061750.1														central_nervous_system(2)|endometrium(9)|kidney(6)|large_intestine(13)|lung(15)|ovary(4)|prostate(3)|stomach(1)|upper_aerodigestive_tract(3)	56			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGAGCAGCTGCGCACCTTCGA	0.692000													18	54					4.96729e-08	5.41547e-08	1	1	0
SERPINA7	6906	broad.mit.edu	37	X	105277537	105277537	+	Missense_Mutation	SNP	C	C	A			TCGA-D6-A6EN-01A-11D-A31L-08	TCGA-D6-A6EN-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	971ca2bc-cd7b-4ce1-a471-81445b85e3a4	20f2c75b-d578-4332-83cb-0e2307d84fff	g.chrX:105277537C>A	ENST00000327674.4	-	4	1537	c.1202G>T	c.(1201-1203)aGg>aTg	p.R401M	SERPINA7_ENST00000372563.1_Missense_Mutation_p.R401M			P05543	THBG_HUMAN	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7	401					regulation of proteolysis	extracellular space	serine-type endopeptidase inhibitor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(14)|ovary(1)|skin(3)	24					Levothyroxine(DB00451)|Liothyronine(DB00279)	GAGAATACTCCTTGTGCTTCT	0.403000													57	56					1.03172e-35	1.22623e-35	1	1	0
MCC	4163	broad.mit.edu	37	5	112379227	112379227	+	Splice_Site	SNP	C	C	T	rs149948216		TCGA-D6-A6EN-01A-11D-A31L-08	TCGA-D6-A6EN-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	971ca2bc-cd7b-4ce1-a471-81445b85e3a4	20f2c75b-d578-4332-83cb-0e2307d84fff	g.chr5:112379227C>T	ENST00000302475.4	-	15	2749	c.2186_splice	c.e15+1	p.R729_splice	MCC_ENST00000408903.3_Splice_Site_p.R919_splice|MCC_ENST00000515367.2_Splice_Site_p.R666_splice|MCC_ENST00000514701.3_5'UTR	NM_002387.2	NP_002378.1	P23508	CRCM_HUMAN	mutated in colorectal cancers	729					negative regulation of canonical Wnt receptor signaling pathway|negative regulation of epithelial cell migration|negative regulation of epithelial cell proliferation|Wnt receptor signaling pathway	cytoplasm|nucleus|plasma membrane	protein binding|receptor activity			endometrium(4)|kidney(3)|large_intestine(15)|liver(2)|lung(8)|ovary(2)|pancreas(1)|prostate(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	42		all_cancers(142;5.89e-08)|all_epithelial(76;3.57e-11)|all_lung(232;0.000605)|Lung NSC(810;0.000697)|Colorectal(10;0.00146)|Prostate(80;0.00174)|Ovarian(225;0.0175)|Breast(839;0.198)		OV - Ovarian serous cystadenocarcinoma(64;2.04e-54)|Epithelial(69;9.69e-49)|all cancers(49;6.25e-44)|COAD - Colon adenocarcinoma(37;0.0432)|Colorectal(14;0.0766)		GGGTGCTTACCGACGAATGGC	0.562000											OREG0016728	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	8	16					0	0	1	0	0
BICD2	23299	broad.mit.edu	37	9	95526892	95526892	+	Silent	SNP	C	C	T			TCGA-D6-A6EN-01A-11D-A31L-08	TCGA-D6-A6EN-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	971ca2bc-cd7b-4ce1-a471-81445b85e3a4	20f2c75b-d578-4332-83cb-0e2307d84fff	g.chr9:95526892C>T	ENST00000356884.6	-	1	202	c.135G>A	c.(133-135)gaG>gaA	p.E45E	BICD2_ENST00000375512.3_Silent_p.E45E	NM_001003800.1	NP_001003800.1	Q8TD16	BICD2_HUMAN	bicaudal D homolog 2 (Drosophila)	45					microtubule anchoring at microtubule organizing center|minus-end-directed organelle transport along microtubule	cytoplasmic vesicle|cytoskeleton|Golgi apparatus|plasma membrane	Rab GTPase binding			cervix(3)|endometrium(4)|kidney(1)|large_intestine(6)|lung(5)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	23						CCAGCCCGTACTCGGCCGCCT	0.662000													3	9					0	0	1	0	0
HRAS	3265	broad.mit.edu	37	11	533873	533873	+	Missense_Mutation	SNP	C	C	A	rs121913496		TCGA-D6-A6EN-01A-11D-A31L-08	TCGA-D6-A6EN-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	971ca2bc-cd7b-4ce1-a471-81445b85e3a4	20f2c75b-d578-4332-83cb-0e2307d84fff	g.chr11:533873C>A	ENST00000417302.1	-	3	370	c.183G>T	c.(181-183)caG>caT	p.Q61H	HRAS_ENST00000468682.2_5'UTR|HRAS_ENST00000397594.1_Missense_Mutation_p.Q61H|HRAS_ENST00000451590.1_Missense_Mutation_p.Q61H|HRAS_ENST00000397596.2_Missense_Mutation_p.Q61H|HRAS_ENST00000311189.7_Missense_Mutation_p.Q61H	NM_176795.3	NP_789765.1	P01112	RASH_HUMAN	Harvey rat sarcoma viral oncogene homolog	61			Q -> K (in follicular thyroid carcinoma samples; somatic mutation; increases transformation of cultured cell lines; dbSNP:rs28933406).|Q -> L (in melanoma; strongly reduced GTP hydrolysis in the presence of RAF1; increases transformation of cultured cell lines).		activation of MAPKK activity|axon guidance|blood coagulation|cell cycle arrest|cellular senescence|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|mitotic cell cycle G1/S transition checkpoint|negative regulation of cell proliferation|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of DNA replication|positive regulation of epithelial cell proliferation|Ras protein signal transduction|synaptic transmission	cytosol|Golgi membrane|plasma membrane	GTP binding|GTPase activity|protein C-terminus binding	p.Q61H(20)|p.Q61R(4)|p.Q61Q(1)|p.Q61L(1)		adrenal_gland(1)|bone(3)|breast(7)|cervix(23)|endometrium(4)|haematopoietic_and_lymphoid_tissue(12)|kidney(1)|large_intestine(2)|liver(1)|lung(16)|oesophagus(2)|penis(2)|pituitary(10)|prostate(31)|salivary_gland(24)|skin(184)|soft_tissue(38)|stomach(14)|testis(5)|thymus(1)|thyroid(173)|upper_aerodigestive_tract(122)|urinary_tract(225)	901		all_cancers(49;4.37e-09)|all_epithelial(84;2.09e-06)|Breast(177;0.000162)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.0538)|all_lung(207;0.0713)		all cancers(45;7.63e-28)|Epithelial(43;7.29e-27)|OV - Ovarian serous cystadenocarcinoma(40;7.15e-21)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0375)|LUSC - Lung squamous cell carcinoma(625;0.0703)	Sulindac(DB00605)	TGTACTCCTCCTGGCCGGCGG	0.602000	Q61H(RL952_ENDOMETRIUM)	6	Mis		"""infrequent sarcomas, rare other types"""	"""rhadomyosarcoma, ganglioneuroblastoma, bladder"""			Costello syndrome	HNSCC(11;0.0054)			34	83					3.93418e-24	4.63786e-24	1	1	0
ITSN2	50618	broad.mit.edu	37	2	24471560	24471560	+	Missense_Mutation	SNP	G	G	A			TCGA-D6-A6EN-01A-11D-A31L-08	TCGA-D6-A6EN-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	971ca2bc-cd7b-4ce1-a471-81445b85e3a4	20f2c75b-d578-4332-83cb-0e2307d84fff	g.chr2:24471560G>A	ENST00000355123.4	-	27	3669	c.3226C>T	c.(3226-3228)Cca>Tca	p.P1076S	ITSN2_ENST00000361999.3_Missense_Mutation_p.P1049S|ITSN2_ENST00000406921.3_Missense_Mutation_p.P1076S	NM_006277.2	NP_006268.2	Q9NZM3	ITSN2_HUMAN	intersectin 2	1076	SH3 4.				endocytosis|regulation of Rho protein signal transduction	cytoplasm	calcium ion binding|Rho guanyl-nucleotide exchange factor activity|SH3/SH2 adaptor activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(8)|large_intestine(11)|liver(3)|lung(28)|ovary(2)|stomach(1)	61	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					AACTGTCCTGGTGCAAGGCTA	0.338000													3	18					0	0	1	0	0
TNXB	7148	broad.mit.edu	37	6	32024589	32024589	+	Silent	SNP	G	G	A			TCGA-D6-A6EN-01A-11D-A31L-08	TCGA-D6-A6EN-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	971ca2bc-cd7b-4ce1-a471-81445b85e3a4	20f2c75b-d578-4332-83cb-0e2307d84fff	g.chr6:32024589G>A	ENST00000375244.3	-	23	8118	c.7917C>T	c.(7915-7917)gcC>gcT	p.A2639A	TNXB_ENST00000375247.2_Silent_p.A2639A			P22105	TENX_HUMAN	tenascin XB	2699	Fibronectin type-III 18.				actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|prostate(1)	8						AGTCAGGGGTGGCATCTGTCA	0.632000													25	70					0	0	1	0	0
FRG1BP	284802	broad.mit.edu	37	20	29628283	29628283	+	Silent	SNP	G	G	C			TCGA-D6-A6EN-01A-11D-A31L-08	TCGA-D6-A6EN-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	971ca2bc-cd7b-4ce1-a471-81445b85e3a4	20f2c75b-d578-4332-83cb-0e2307d84fff	g.chr20:29628283G>C	ENST00000278882.3	+	6	665	c.285G>C	c.(283-285)ggG>ggC	p.G95G	FRG1B_ENST00000439954.2_Silent_p.G100G|FRG1B_ENST00000358464.4_Silent_p.G95G														p.G95G(4)		endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						ATGAAGCAGGGGACATAGAAG	0.378000													6	102					0	0	1	0	0
PROL1	58503	broad.mit.edu	37	4	71275591	71275591	+	Silent	SNP	C	C	T			TCGA-D6-A6EN-01A-11D-A31L-08	TCGA-D6-A6EN-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	971ca2bc-cd7b-4ce1-a471-81445b85e3a4	20f2c75b-d578-4332-83cb-0e2307d84fff	g.chr4:71275591C>T	ENST00000399575.2	+	3	720	c.546C>T	c.(544-546)atC>atT	p.I182I	PROL1_ENST00000514338.1_3'UTR	NM_021225.4	NP_067048.4	Q99935	PROL1_HUMAN	proline rich, lacrimal 1	182	Thr-rich.				regulation of sensory perception of pain	extracellular region	endopeptidase inhibitor activity			endometrium(1)|kidney(1)|large_intestine(2)|lung(7)|prostate(1)|skin(3)	15		all_hematologic(202;0.196)				CAGTACCTATCTCTTCAACAC	0.498000													27	69					0	0	1	0	0
POU6F2	11281	broad.mit.edu	37	7	39500196	39500196	+	Nonsense_Mutation	SNP	C	C	T	rs145241880		TCGA-D6-A6EN-01A-11D-A31L-08	TCGA-D6-A6EN-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	971ca2bc-cd7b-4ce1-a471-81445b85e3a4	20f2c75b-d578-4332-83cb-0e2307d84fff	g.chr7:39500196C>T	ENST00000518318.2	+	9	1495	c.1453C>T	c.(1453-1455)Cga>Tga	p.R485*	POU6F2_ENST00000403058.1_Nonsense_Mutation_p.R485*|POU6F2_ENST00000559001.1_Nonsense_Mutation_p.R430*			P78424	PO6F2_HUMAN	POU class 6 homeobox 2	485	POU-specific.				central nervous system development|ganglion mother cell fate determination|transcription from RNA polymerase II promoter|visual perception		sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			NS(3)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(16)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	42						GGAGGAGATCCGAGAATTTGC	0.532000													6	17					0	0	1	0	0
TMEM110	375346	broad.mit.edu	37	3	52878919	52878919	+	Missense_Mutation	SNP	C	C	A			TCGA-D6-A6EN-01A-11D-A31L-08	TCGA-D6-A6EN-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	971ca2bc-cd7b-4ce1-a471-81445b85e3a4	20f2c75b-d578-4332-83cb-0e2307d84fff	g.chr3:52878919C>A	ENST00000355083.5	-	5	611	c.466G>T	c.(466-468)Gct>Tct	p.A156S	TMEM110-MUSTN1_ENST00000504329.1_Missense_Mutation_p.A156S	NM_198563.2	NP_940965.1			transmembrane protein 110											kidney(1)|large_intestine(1)|lung(2)	4				BRCA - Breast invasive adenocarcinoma(193;7.72e-05)|Kidney(197;0.000777)|KIRC - Kidney renal clear cell carcinoma(197;0.000915)|OV - Ovarian serous cystadenocarcinoma(275;0.0541)		ATGTAAAGAGCGCACTGCCCG	0.537000													13	65					0.00244969	0.00250145	1	1	0
ANKRD30BP2	149992	broad.mit.edu	37	21	14414844	14414844	+	RNA	SNP	T	T	C	rs148060711	by1000genomes	TCGA-D6-A6EN-01A-11D-A31L-08	TCGA-D6-A6EN-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	971ca2bc-cd7b-4ce1-a471-81445b85e3a4	20f2c75b-d578-4332-83cb-0e2307d84fff	g.chr21:14414844T>C	ENST00000507941.1	+	0	95																											ACTGGGCCTGTGCCAATGGCC	0.433000													4	36					0	0	1	0	0
KIAA2022	340533	broad.mit.edu	37	X	73963134	73963134	+	Missense_Mutation	SNP	G	G	T			TCGA-D6-A6EN-01A-11D-A31L-08	TCGA-D6-A6EN-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	971ca2bc-cd7b-4ce1-a471-81445b85e3a4	20f2c75b-d578-4332-83cb-0e2307d84fff	g.chrX:73963134G>T	ENST00000373468.1	-	3	1909	c.1258C>A	c.(1258-1260)Caa>Aaa	p.Q420K	KIAA2022_ENST00000055682.5_Missense_Mutation_p.Q420K			Q5QGS0	K2022_HUMAN	KIAA2022	420					base-excision repair, gap-filling|DNA replication proofreading|DNA replication, removal of RNA primer|nucleotide-excision repair, DNA gap filling|regulation of mitotic cell cycle|S phase of mitotic cell cycle	delta DNA polymerase complex	3'-5'-exodeoxyribonuclease activity|DNA-directed DNA polymerase activity			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(23)|liver(1)|lung(41)|ovary(7)|pancreas(2)|prostate(4)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(3)	109						TTCTTAAGTTGCTCTACTTCA	0.423000													42	38					3.43241e-23	4.01371e-23	1	1	0
GRIN3A	116443	broad.mit.edu	37	9	104499889	104499889	+	Missense_Mutation	SNP	G	G	A			TCGA-D6-A6EN-01A-11D-A31L-08	TCGA-D6-A6EN-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	971ca2bc-cd7b-4ce1-a471-81445b85e3a4	20f2c75b-d578-4332-83cb-0e2307d84fff	g.chr9:104499889G>A	ENST00000361820.3	-	1	973	c.373C>T	c.(373-375)Cgg>Tgg	p.R125W		NM_133445.2	NP_597702.2	Q8TCU5	NMD3A_HUMAN	glutamate receptor, ionotropic, N-methyl-D-aspartate 3A	125					response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|neuron projection|neuronal cell body|outer membrane-bounded periplasmic space|postsynaptic density|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|glycine binding|identical protein binding|N-methyl-D-aspartate selective glutamate receptor activity|protein phosphatase 2A binding			breast(2)|central_nervous_system(2)|endometrium(4)|kidney(3)|large_intestine(12)|lung(44)|ovary(4)|pancreas(1)|skin(7)|upper_aerodigestive_tract(1)	80		Acute lymphoblastic leukemia(62;0.0568)			Acamprosate(DB00659)|Chloroprocaine(DB01161)|Dextromethorphan(DB00514)|Ethanol(DB00898)|Ethopropazine(DB00392)|Felbamate(DB00949)|Ketamine(DB01221)|L-Glutamic Acid(DB00142)|Memantine(DB01043)|Meperidine(DB00454)|Methadone(DB00333)|Orphenadrine(DB01173)|Procaine(DB00721)|Riluzole(DB00740)	AGGGCGTCCCGTGGCCACAGG	0.697000													5	29					0	0	1	0	0
L3MBTL4	91133	broad.mit.edu	37	18	6263958	6263958	+	Missense_Mutation	SNP	C	C	A			TCGA-D6-A6EN-01A-11D-A31L-08	TCGA-D6-A6EN-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	971ca2bc-cd7b-4ce1-a471-81445b85e3a4	20f2c75b-d578-4332-83cb-0e2307d84fff	g.chr18:6263958C>A	ENST00000400104.3	-	5	407	c.207G>T	c.(205-207)gaG>gaT	p.E69D	L3MBTL4_ENST00000317931.7_Missense_Mutation_p.E69D|L3MBTL4_ENST00000284898.6_Missense_Mutation_p.E69D|L3MBTL4_ENST00000400105.2_Missense_Mutation_p.E69D			Q8NA19	LMBL4_HUMAN	l(3)mbt-like 4 (Drosophila)	69					chromatin modification	nucleus	sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(17)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	39		Colorectal(10;0.0249)				TGGAAAACAGCTCAACAGGTG	0.453000													7	48					2.17888e-05	2.30611e-05	1	1	0
NOTCH1	4851	broad.mit.edu	37	9	139413161	139413161	+	Missense_Mutation	SNP	C	C	G			TCGA-D6-A6EN-01A-11D-A31L-08	TCGA-D6-A6EN-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	971ca2bc-cd7b-4ce1-a471-81445b85e3a4	20f2c75b-d578-4332-83cb-0e2307d84fff	g.chr9:139413161C>G	ENST00000277541.6	-	6	1056	c.981G>C	c.(979-981)tgG>tgC	p.W327C		NM_017617.3	NP_060087.3	P46531	NOTC1_HUMAN	notch 1	327	EGF-like 8; calcium-binding (Potential).				aortic valve morphogenesis|immune response|negative regulation of BMP signaling pathway|negative regulation of cell-substrate adhesion|negative regulation of myoblast differentiation|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-dependent|Notch receptor processing	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			breast(16)|central_nervous_system(17)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1183)|kidney(4)|large_intestine(1)|lung(57)|oesophagus(2)|ovary(3)|pancreas(1)|prostate(3)|skin(21)|upper_aerodigestive_tract(39)|urinary_tract(3)	1359	all_cancers(76;0.223)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.34e-06)|Epithelial(140;7.77e-06)		CCTCACCAGTCCAGCCGTTGA	0.617000			"""T, Mis, O"""	TRB@	T-ALL					HNSCC(8;0.001)			52	14					0	0	1	0	0
BRAF	673	broad.mit.edu	37	7	140481411	140481411	+	Missense_Mutation	SNP	C	C	T			TCGA-D6-A6EN-01A-11D-A31L-08	TCGA-D6-A6EN-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	971ca2bc-cd7b-4ce1-a471-81445b85e3a4	20f2c75b-d578-4332-83cb-0e2307d84fff	g.chr7:140481411C>T	ENST00000288602.6	-	11	1457	c.1397G>A	c.(1396-1398)gGa>gAa	p.G466E		NM_004333.4	NP_004324.2	P15056	BRAF_HUMAN	v-raf murine sarcoma viral oncogene homolog B	466	Protein kinase.		G -> A (in melanoma).|G -> E (in melanoma).|G -> V (in LNCR).		activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding	p.G466V(15)|p.G466E(5)|p.G466A(1)	SLC45A3/BRAF(2)|AGTRAP/BRAF(2)|FAM131B_ENST00000443739/BRAF(7)|AKAP9_ENST00000356239/BRAF(10)|KIAA1549/BRAF(703)|FCHSD1/BRAF(2)	NS(588)|adrenal_gland(3)|autonomic_ganglia(3)|biliary_tract(29)|bone(7)|breast(21)|central_nervous_system(99)|cervix(6)|endometrium(33)|eye(72)|gastrointestinal_tract_(site_indeterminate)(2)|genital_tract(4)|haematopoietic_and_lymphoid_tissue(436)|kidney(3)|large_intestine(6953)|liver(17)|lung(192)|oesophagus(4)|ovary(275)|pancreas(15)|pituitary(1)|prostate(25)|salivary_gland(1)|skin(6285)|small_intestine(12)|soft_tissue(40)|stomach(11)|testis(7)|thyroid(12220)|upper_aerodigestive_tract(13)|urinary_tract(3)	27380	Melanoma(164;0.00956)				Sorafenib(DB00398)	TCCAAATGATCCAGATCCAAT	0.378000	G466V(CAL12T_LUNG)|G466V(NCIH1666_LUNG)	61	"""Mis, T, O"""	"""AKAP9, KIAA1549"""	"""melanoma, colorectal, papillary thyroid, borderline ov, Non small-cell lung cancer (NSCLC), cholangiocarcinoma, pilocytic astrocytoma"""		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous syndrome				30	84					0	0	1	0	0
NINL	22981	broad.mit.edu	37	20	25436366	25436366	+	Missense_Mutation	SNP	C	C	A			TCGA-D6-A6EN-01A-11D-A31L-08	TCGA-D6-A6EN-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	971ca2bc-cd7b-4ce1-a471-81445b85e3a4	20f2c75b-d578-4332-83cb-0e2307d84fff	g.chr20:25436366C>A	ENST00000278886.6	-	23	3973	c.3900G>T	c.(3898-3900)atG>atT	p.M1300I	NINL_ENST00000464285.1_5'UTR|NINL_ENST00000422516.1_Missense_Mutation_p.M951I	NM_025176.4	NP_079452.3	Q9Y2I6	NINL_HUMAN	ninein-like	1300					G2/M transition of mitotic cell cycle	cytosol|microtubule|microtubule organizing center	calcium ion binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(13)|lung(25)|ovary(2)|pancreas(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	57						TCTTCAGAATCATCTCCGCCT	0.517000													50	191					2.48909e-17	2.86443e-17	1	1	0
PRUNE2	158471	broad.mit.edu	37	9	79318958	79318958	+	Missense_Mutation	SNP	G	G	T			TCGA-D6-A6EN-01A-11D-A31L-08	TCGA-D6-A6EN-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	971ca2bc-cd7b-4ce1-a471-81445b85e3a4	20f2c75b-d578-4332-83cb-0e2307d84fff	g.chr9:79318958G>T	ENST00000428286.1	-	9	7694	c.6494C>A	c.(6493-6495)cCt>cAt	p.P2165H	PRUNE2_ENST00000376718.3_Missense_Mutation_p.P2524H			Q8WUY3	PRUN2_HUMAN	prune homolog 2 (Drosophila)	2524					apoptosis|G1 phase|induction of apoptosis	cytoplasm	metal ion binding|pyrophosphatase activity			endometrium(1)|kidney(4)|large_intestine(3)|lung(7)|prostate(1)	16						TATCTGCTCAGGCTCTTTGGT	0.373000													16	114					2.62699e-14	2.97588e-14	1	1	0
PDZD2	23037	broad.mit.edu	37	5	31983414	31983414	+	Silent	SNP	G	G	A			TCGA-D6-A6EN-01A-11D-A31L-08	TCGA-D6-A6EN-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	971ca2bc-cd7b-4ce1-a471-81445b85e3a4	20f2c75b-d578-4332-83cb-0e2307d84fff	g.chr5:31983414G>A	ENST00000438447.1	+	3	1018	c.630G>A	c.(628-630)gcG>gcA	p.A210A	PDZD2_ENST00000282493.3_Silent_p.A210A			O15018	PDZD2_HUMAN	PDZ domain containing 2	210					cell adhesion	cell-cell junction|endoplasmic reticulum|extracellular region|nucleus				NS(2)|breast(4)|central_nervous_system(5)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(31)|lung(58)|ovary(6)|prostate(2)|skin(8)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	148						ACCGAACTGCGAAAAAGGGGA	0.537000													25	57					0	0	1	0	0
UBALD1	124402	broad.mit.edu	37	16	4659674	4659674	+	Nonsense_Mutation	SNP	G	G	C			TCGA-D6-A6EN-01A-11D-A31L-08	TCGA-D6-A6EN-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	971ca2bc-cd7b-4ce1-a471-81445b85e3a4	20f2c75b-d578-4332-83cb-0e2307d84fff	g.chr16:4659674G>C	ENST00000590891.1	-	1	1850	c.599C>G	c.(598-600)tCa>tGa	p.S200*	UBALD1_ENST00000591897.1_Nonsense_Mutation_p.S105*|UBALD1_ENST00000283474.7_Nonsense_Mutation_p.S165*|UBALD1_ENST00000587615.1_Nonsense_Mutation_p.S140*|UBALD1_ENST00000590965.1_3'UTR|UBALD1_ENST00000591401.1_Nonsense_Mutation_p.S144*					UBA-like domain containing 1																		CCTGGGTTCTGAGGTGGCCTG	0.716000													10	32					0	0	1	0	0
UNC79	57578	broad.mit.edu	37	14	94069643	94069643	+	Silent	SNP	C	C	A			TCGA-D6-A6EN-01A-11D-A31L-08	TCGA-D6-A6EN-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	971ca2bc-cd7b-4ce1-a471-81445b85e3a4	20f2c75b-d578-4332-83cb-0e2307d84fff	g.chr14:94069643C>A	ENST00000553484.1	+	26	3787	c.3633C>A	c.(3631-3633)atC>atA	p.I1211I	UNC79_ENST00000256339.4_Silent_p.I1034I|UNC79_ENST00000555664.1_Silent_p.I1211I|UNC79_ENST00000393151.2_Silent_p.I1211I			Q9P2D8	UNC79_HUMAN	unc-79 homolog (C. elegans)	1211						integral to membrane				breast(3)|cervix(2)|endometrium(10)|kidney(7)|large_intestine(18)|liver(1)|lung(64)|ovary(1)|prostate(5)|skin(3)|urinary_tract(4)	118						TATGGAAGATCAAGAGAGCTC	0.512000													20	68					2.37509e-13	2.66968e-13	1	1	0
KBTBD12	166348	broad.mit.edu	37	3	127682161	127682161	+	Missense_Mutation	SNP	G	G	A			TCGA-D6-A6EN-01A-11D-A31L-08	TCGA-D6-A6EN-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	971ca2bc-cd7b-4ce1-a471-81445b85e3a4	20f2c75b-d578-4332-83cb-0e2307d84fff	g.chr3:127682161G>A	ENST00000405109.1	+	5	2089	c.1622G>A	c.(1621-1623)cGc>cAc	p.R541H	KBTBD12_ENST00000343941.4_Missense_Mutation_p.R116H|KBTBD12_ENST00000405256.1_Missense_Mutation_p.R541H|KBTBD12_ENST00000407609.3_Missense_Mutation_p.R148H|KBTBD12_ENST00000492025.1_3'UTR			Q3ZCT8	KBTBC_HUMAN	kelch repeat and BTB (POZ) domain containing 12	541										endometrium(1)|large_intestine(6)|lung(5)|ovary(1)	13						CTCTCACTCCGCACCAATTCC	0.542000													8	12					0	0	1	0	0
C5orf34	375444	broad.mit.edu	37	5	43506488	43506488	+	Silent	SNP	G	G	A			TCGA-D6-A6EN-01A-11D-A31L-08	TCGA-D6-A6EN-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	971ca2bc-cd7b-4ce1-a471-81445b85e3a4	20f2c75b-d578-4332-83cb-0e2307d84fff	g.chr5:43506488G>A	ENST00000306862.2	-	4	669	c.294C>T	c.(292-294)ttC>ttT	p.F98F	RP11-159F24.3_ENST00000505645.1_RNA	NM_198566.2	NP_940968.1	Q96MH7	CE034_HUMAN	chromosome 5 open reading frame 34	98										breast(2)|endometrium(2)|large_intestine(2)|lung(11)|ovary(1)|prostate(1)|stomach(2)	21	Lung NSC(6;2.07e-05)					TTATGTCAATGAAGATATGCT	0.368000													10	16					0	0	1	0	0
CIZ1	25792	broad.mit.edu	37	9	130941637	130941637	+	Silent	SNP	C	C	T			TCGA-D6-A6EN-01A-11D-A31L-08	TCGA-D6-A6EN-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	971ca2bc-cd7b-4ce1-a471-81445b85e3a4	20f2c75b-d578-4332-83cb-0e2307d84fff	g.chr9:130941637C>T	ENST00000538431.1	-	8	1096	c.849G>A	c.(847-849)ccG>ccA	p.P283P	CIZ1_ENST00000476727.2_Intron|CIZ1_ENST00000277465.4_Silent_p.P283P|CIZ1_ENST00000372938.5_Silent_p.P283P|CIZ1_ENST00000393608.1_Silent_p.P283P|CIZ1_ENST00000372954.1_Silent_p.P259P|CIZ1_ENST00000541172.1_Silent_p.P182P|CIZ1_ENST00000357558.5_Silent_p.P283P|CIZ1_ENST00000325721.8_Silent_p.P254P|CIZ1_ENST00000372948.3_Silent_p.P283P	NM_001257975.1	NP_001244904.1	Q9ULV3	CIZ1_HUMAN	CDKN1A interacting zinc finger protein 1	283	Gln-rich.					nucleus	nucleic acid binding|protein binding|zinc ion binding			NS(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(8)|liver(1)|lung(9)|ovary(3)|prostate(2)|urinary_tract(2)	35						TCCGGGCCTGCGGCTGGGCCT	0.567000													18	67					0	0	1	0	0
TEX15	56154	broad.mit.edu	37	8	30695298	30695298	+	Silent	SNP	C	C	T			TCGA-D6-A6EN-01A-11D-A31L-08	TCGA-D6-A6EN-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	971ca2bc-cd7b-4ce1-a471-81445b85e3a4	20f2c75b-d578-4332-83cb-0e2307d84fff	g.chr8:30695298C>T	ENST00000256246.2	-	3	7427	c.7353G>A	c.(7351-7353)aaG>aaA	p.K2451K		NM_031271.3	NP_112561.2	Q9BXT5	TEX15_HUMAN	testis expressed 15	2451										NS(2)|breast(3)|cervix(5)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(38)|lung(56)|ovary(5)|pancreas(1)|prostate(2)|skin(7)|upper_aerodigestive_tract(5)|urinary_tract(1)	138				KIRC - Kidney renal clear cell carcinoma(542;0.0918)|Kidney(114;0.111)		CACAATCTTTCTTATCACTTT	0.358000													30	116					0	0	1	0	0
PCDHGA12	26025	broad.mit.edu	37	5	140812097	140812097	+	Missense_Mutation	SNP	G	G	A			TCGA-D6-A6EN-01A-11D-A31L-08	TCGA-D6-A6EN-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	971ca2bc-cd7b-4ce1-a471-81445b85e3a4	20f2c75b-d578-4332-83cb-0e2307d84fff	g.chr5:140812097G>A	ENST00000252085.3	+	1	1913	c.1771G>A	c.(1771-1773)Gtg>Atg	p.V591M	PCDHGA11_ENST00000518882.1_Intron|PCDHGA10_ENST00000398610.2_Intron|PCDHGB7_ENST00000398594.2_Intron|PCDHGA8_ENST00000398604.2_Intron|PCDHGB3_ENST00000576222.1_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGB4_ENST00000519479.1_Intron|PCDHGA7_ENST00000518325.1_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGA6_ENST00000517434.1_Intron|PCDHGA11_ENST00000398587.2_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA9_ENST00000573521.1_Intron|PCDHGB6_ENST00000520790.1_Intron	NM_003735.2|NM_032094.1	NP_003726.1|NP_115265.1														breast(2)|cervix(1)|endometrium(7)|kidney(1)|large_intestine(10)|lung(23)|ovary(5)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)	58			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGTGACCAAGGTGGTGGCGGT	0.687000													50	117					0	0	1	0	0
DNAJC5B	85479	broad.mit.edu	37	8	66992739	66992739	+	Missense_Mutation	SNP	C	C	T			TCGA-D6-A6EN-01A-11D-A31L-08	TCGA-D6-A6EN-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	971ca2bc-cd7b-4ce1-a471-81445b85e3a4	20f2c75b-d578-4332-83cb-0e2307d84fff	g.chr8:66992739C>T	ENST00000276570.5	+	5	748	c.461C>T	c.(460-462)tCc>tTc	p.S154F	DNAJC5B_ENST00000519330.1_3'UTR	NM_033105.4	NP_149096.2	Q9UF47	DNJ5B_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 5 beta	154					protein folding	membrane	heat shock protein binding|unfolded protein binding			endometrium(3)|large_intestine(6)|liver(1)|lung(6)|prostate(1)|skin(3)	20		Lung NSC(129;0.114)|all_lung(136;0.188)	Epithelial(68;0.0213)|all cancers(69;0.0839)|BRCA - Breast invasive adenocarcinoma(89;0.0886)|OV - Ovarian serous cystadenocarcinoma(28;0.112)			TTCTATGTGTCCCCAGAGGAT	0.552000													7	15					0	0	1	0	0
OSBPL5	114879	broad.mit.edu	37	11	3109525	3109525	+	Silent	SNP	C	C	G			TCGA-D6-A6EN-01A-11D-A31L-08	TCGA-D6-A6EN-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	971ca2bc-cd7b-4ce1-a471-81445b85e3a4	20f2c75b-d578-4332-83cb-0e2307d84fff	g.chr11:3109525C>G	ENST00000263650.7	-	22	2709	c.2550G>C	c.(2548-2550)ccG>ccC	p.P850P	OSBPL5_ENST00000525498.1_Silent_p.P761P|OSBPL5_ENST00000348039.5_Silent_p.P782P|OSBPL5_ENST00000542243.1_Silent_p.P481P|OSBPL5_ENST00000389989.3_Silent_p.P782P|OSBPL5_ENST00000478260.1_Silent_p.P304P	NM_020896.3	NP_065947.1	Q9H0X9	OSBL5_HUMAN	oxysterol binding protein-like 5	850					cholesterol metabolic process|cholesterol transport|Golgi to plasma membrane transport	cytosol	oxysterol binding|protein binding			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(7)|lung(8)|prostate(1)|upper_aerodigestive_tract(1)	25		all_epithelial(84;0.000236)|Medulloblastoma(188;0.00106)|Breast(177;0.00328)|Ovarian(85;0.00556)|all_neural(188;0.00681)		BRCA - Breast invasive adenocarcinoma(625;0.00607)|LUSC - Lung squamous cell carcinoma(625;0.207)		GGCCTGGGGTCGGTGCCTGTG	0.632000													10	29					0	0	1	0	0
RMND5B	64777	broad.mit.edu	37	5	177569714	177569714	+	Silent	SNP	C	C	A			TCGA-D6-A6EN-01A-11D-A31L-08	TCGA-D6-A6EN-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	971ca2bc-cd7b-4ce1-a471-81445b85e3a4	20f2c75b-d578-4332-83cb-0e2307d84fff	g.chr5:177569714C>A	ENST00000515098.1	+	5	621	c.270C>A	c.(268-270)ggC>ggA	p.G90G	RMND5B_ENST00000313386.4_Silent_p.G90G|RMND5B_ENST00000542098.1_Silent_p.G77G			Q96G75	RMD5B_HUMAN	required for meiotic nuclear division 5 homolog B (S. cerevisiae)	90										endometrium(3)|large_intestine(5)|lung(6)|ovary(1)|skin(2)	17	all_cancers(89;0.00294)|Renal(175;0.000269)|Lung NSC(126;0.00858)|all_lung(126;0.0139)	all_neural(177;0.00802)|Medulloblastoma(196;0.0145)|all_hematologic(541;0.248)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CCCGAGTGGGCAAAGCCATTG	0.567000													20	67					1.40151e-16	1.60015e-16	1	1	0
DNAH9	1770	broad.mit.edu	37	17	11666861	11666861	+	Missense_Mutation	SNP	A	A	C			TCGA-D6-A6EN-01A-11D-A31L-08	TCGA-D6-A6EN-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	971ca2bc-cd7b-4ce1-a471-81445b85e3a4	20f2c75b-d578-4332-83cb-0e2307d84fff	g.chr17:11666861A>C	ENST00000262442.3	+	36	7168	c.7100A>C	c.(7099-7101)aAg>aCg	p.K2367T	DNAH9_ENST00000454412.2_Missense_Mutation_p.K2367T	NM_001372.3	NP_001363.2	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9	2367					cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(2)|autonomic_ganglia(1)|breast(15)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(6)|kidney(17)|large_intestine(49)|liver(2)|lung(123)|ovary(6)|pancreas(1)|prostate(6)|skin(21)|stomach(2)|upper_aerodigestive_tract(13)|urinary_tract(4)	290		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		GACTGCCCTAAGGAAATTTAT	0.488000													16	53					0	0	1	0	0
BCL3	602	broad.mit.edu	37	19	45259540	45259540	+	Silent	SNP	G	G	A			TCGA-D6-A6EN-01A-11D-A31L-08	TCGA-D6-A6EN-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	971ca2bc-cd7b-4ce1-a471-81445b85e3a4	20f2c75b-d578-4332-83cb-0e2307d84fff	g.chr19:45259540G>A	ENST00000164227.5	+	3	706	c.462G>A	c.(460-462)ctG>ctA	p.L154L		NM_005178.4	NP_005169.2	P20749	BCL3_HUMAN	B-cell CLL/lymphoma 3	154					DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|I-kappaB kinase/NF-kappaB cascade|maintenance of protein location in nucleus|negative regulation of apoptosis|negative regulation of interleukin-8 biosynthetic process|negative regulation of transcription, DNA-dependent|positive regulation of translation|protein import into nucleus, translocation|regulation of DNA binding|regulation of NF-kappaB import into nucleus|response to UV-C|response to virus	Bcl3-Bcl10 complex|Bcl3/NF-kappaB2 complex|nucleus|perinuclear region of cytoplasm	protein binding, bridging|transcription factor binding			kidney(1)|large_intestine(2)|lung(2)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	10	Lung NSC(12;0.000698)|all_lung(12;0.002)	Ovarian(192;0.0728)				TGCACCGGCTGGTCAACCTCT	0.622000			T	IGH@	CLL								6	25					0	0	1	0	0
IRF4	3662	broad.mit.edu	37	6	407546	407546	+	Missense_Mutation	SNP	G	G	A			TCGA-D6-A6EN-01A-11D-A31L-08	TCGA-D6-A6EN-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	971ca2bc-cd7b-4ce1-a471-81445b85e3a4	20f2c75b-d578-4332-83cb-0e2307d84fff	g.chr6:407546G>A	ENST00000380956.4	+	9	1430	c.1304G>A	c.(1303-1305)aGc>aAc	p.S435N		NM_001195286.1|NM_002460.3	NP_001182215.1|NP_002451.2	Q15306	IRF4_HUMAN	interferon regulatory factor 4	435					interferon-gamma-mediated signaling pathway|positive regulation of interleukin-10 biosynthetic process|positive regulation of interleukin-13 biosynthetic process|positive regulation of interleukin-2 biosynthetic process|positive regulation of interleukin-4 biosynthetic process|positive regulation of transcription, DNA-dependent|regulation of T-helper cell differentiation|T cell activation|type I interferon-mediated signaling pathway	cytoplasm	DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding			haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|ovary(2)	5		Breast(5;0.0155)|all_lung(73;0.0691)|all_hematologic(90;0.0895)		OV - Ovarian serous cystadenocarcinoma(45;0.03)|BRCA - Breast invasive adenocarcinoma(62;0.0702)		GAACACATCAGCAATCCAGAA	0.353000			T	IGH@	MM								13	44					0	0	1	0	0
ZNF608	57507	broad.mit.edu	37	5	123984545	123984545	+	Missense_Mutation	SNP	T	T	C			TCGA-D6-A6EN-01A-11D-A31L-08	TCGA-D6-A6EN-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	971ca2bc-cd7b-4ce1-a471-81445b85e3a4	20f2c75b-d578-4332-83cb-0e2307d84fff	g.chr5:123984545T>C	ENST00000306315.5	-	4	1967	c.1532A>G	c.(1531-1533)aAc>aGc	p.N511S	ZNF608_ENST00000504926.1_Missense_Mutation_p.N84S	NM_020747.2	NP_065798.2	Q9ULD9	ZN608_HUMAN	zinc finger protein 608	511						intracellular	zinc ion binding			breast(4)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(8)|lung(12)|ovary(3)|skin(6)|urinary_tract(1)	46		all_cancers(142;0.186)|Prostate(80;0.081)	KIRC - Kidney renal clear cell carcinoma(527;0.159)|Kidney(363;0.221)	OV - Ovarian serous cystadenocarcinoma(64;0.00126)|Epithelial(69;0.00238)|all cancers(49;0.00783)		AGAGCTGGAGTTCAGGTCCAG	0.512000													19	54					0	0	1	0	0
ANKRD30BP2	149992	broad.mit.edu	37	21	14414902	14414902	+	RNA	SNP	G	G	A	rs2821609	by1000genomes	TCGA-D6-A6EN-01A-11D-A31L-08	TCGA-D6-A6EN-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	971ca2bc-cd7b-4ce1-a471-81445b85e3a4	20f2c75b-d578-4332-83cb-0e2307d84fff	g.chr21:14414902G>A	ENST00000507941.1	+	0	95																											CCAGCTTGACGTCCTTGATGG	0.443000													4	21					0	0	1	0	0
C6	729	broad.mit.edu	37	5	41158815	41158815	+	Silent	SNP	C	C	A			TCGA-D6-A6EN-01A-11D-A31L-08	TCGA-D6-A6EN-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	971ca2bc-cd7b-4ce1-a471-81445b85e3a4	20f2c75b-d578-4332-83cb-0e2307d84fff	g.chr5:41158815C>A	ENST00000263413.3	-	13	2193	c.1929G>T	c.(1927-1929)ggG>ggT	p.G643G	C6_ENST00000337836.5_Silent_p.G643G	NM_001115131.1	NP_001108603.2	P13671	CO6_HUMAN	complement component 6	643	C5b-binding domain.|Sushi 1.				complement activation, classical pathway|cytolysis|innate immune response	membrane attack complex	protein binding			central_nervous_system(2)|cervix(2)|endometrium(2)|kidney(7)|large_intestine(16)|liver(1)|lung(51)|ovary(3)|prostate(1)|skin(9)|upper_aerodigestive_tract(2)	96		Breast(839;1.07e-05)|Ovarian(839;0.0228)|Lung SC(612;0.0548)|Lung NSC(810;0.128)|all_neural(839;0.157)				GCTGAGGACACCCGGAATCTG	0.403000													7	36					0.00307968	0.00312275	1	1	0
HIST1H2AE	3012	broad.mit.edu	37	6	26217341	26217341	+	Missense_Mutation	SNP	G	G	A			TCGA-D6-A6EN-01A-11D-A31L-08	TCGA-D6-A6EN-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	971ca2bc-cd7b-4ce1-a471-81445b85e3a4	20f2c75b-d578-4332-83cb-0e2307d84fff	g.chr6:26217341G>A	ENST00000303910.2	+	1	177	c.139G>A	c.(139-141)Ggc>Agc	p.G47S		NM_021052.2	NP_066390.1	P04908	H2A1B_HUMAN	histone cluster 1, H2ae	47					nucleosome assembly	nucleosome|nucleus	DNA binding			central_nervous_system(1)|endometrium(2)|large_intestine(1)|lung(3)|ovary(1)|skin(2)	10		all_hematologic(11;0.196)				AGTCGGGGCCGGCGCTCCAGT	0.587000													15	45					0	0	1	0	0
BMP6	654	broad.mit.edu	37	6	7727541	7727541	+	Missense_Mutation	SNP	A	A	T			TCGA-D6-A6EN-01A-11D-A31L-08	TCGA-D6-A6EN-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	971ca2bc-cd7b-4ce1-a471-81445b85e3a4	20f2c75b-d578-4332-83cb-0e2307d84fff	g.chr6:7727541A>T	ENST00000283147.6	+	1	512	c.353A>T	c.(352-354)cAg>cTg	p.Q118L		NM_001718.4	NP_001709.1	P22004	BMP6_HUMAN	bone morphogenetic protein 6	118					BMP signaling pathway|cartilage development|growth|immune response|positive regulation of aldosterone biosynthetic process|positive regulation of bone mineralization|positive regulation of osteoblast differentiation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of transcription from RNA polymerase II promoter|SMAD protein signal transduction	extracellular space	BMP receptor binding|cytokine activity|growth factor activity|protein heterodimerization activity	p.Q118L(1)		breast(1)|endometrium(3)|kidney(2)|large_intestine(9)|lung(6)|ovary(1)|prostate(1)	23	Ovarian(93;0.0721)					cagcagcagcagcTGCCTCGC	0.731000													3	14					0	0	1	0	0
CCL25	6370	broad.mit.edu	37	19	8122796	8122796	+	Missense_Mutation	SNP	C	C	G			TCGA-D6-A6EN-01A-11D-A31L-08	TCGA-D6-A6EN-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	971ca2bc-cd7b-4ce1-a471-81445b85e3a4	20f2c75b-d578-4332-83cb-0e2307d84fff	g.chr19:8122796C>G	ENST00000253451.4	+	5	540	c.434C>G	c.(433-435)gCt>gGt	p.A145G	CCL25_ENST00000390669.3_Missense_Mutation_p.A146G	NM_001201359.1|NM_005624.3	NP_001188288.1|NP_005615.2	O15444	CCL25_HUMAN	chemokine (C-C motif) ligand 25	146					chemotaxis|G-protein coupled receptor protein signaling pathway|immune response|inflammatory response	extracellular space|soluble fraction	CCR10 chemokine receptor binding|chemokine activity|hormone activity			NS(1)|endometrium(1)|lung(1)|skin(1)|urinary_tract(1)	5						ctgatatcagctaattcaggt	0.478000													18	64					0	0	1	0	0
TOMM20	9804	broad.mit.edu	37	1	235291945	235291945	+	Missense_Mutation	SNP	C	C	T			TCGA-D6-A6EN-01A-11D-A31L-08	TCGA-D6-A6EN-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	971ca2bc-cd7b-4ce1-a471-81445b85e3a4	20f2c75b-d578-4332-83cb-0e2307d84fff	g.chr1:235291945C>T	ENST00000366607.4	-	1	306	c.86G>A	c.(85-87)cGa>cAa	p.R29Q		NM_014765.2	NP_055580.1	Q15388	TOM20_HUMAN	translocase of outer mitochondrial membrane 20 homolog (yeast)	29					protein targeting to mitochondrion	integral to membrane|mitochondrial outer membrane translocase complex	P-P-bond-hydrolysis-driven protein transmembrane transporter activity|unfolded protein binding			lung(2)|prostate(1)	3	Ovarian(103;0.0398)	all_cancers(173;0.177)|Prostate(94;0.0166)	OV - Ovarian serous cystadenocarcinoma(106;6.33e-05)|Epithelial(3;8.26e-05)			GGGGTCACTTCGTCTTTTGCG	0.602000													39	106					0	0	1	0	0
IGHV4-59	28392	broad.mit.edu	37	14	107083671	107083671	+	RNA	SNP	C	C	T			TCGA-D6-A6EN-01A-11D-A31L-08	TCGA-D6-A6EN-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	971ca2bc-cd7b-4ce1-a471-81445b85e3a4	20f2c75b-d578-4332-83cb-0e2307d84fff	g.chr14:107083671C>T	ENST00000455737.1	-	0	54																											GAAGGAAGAACCACAGATGTT	0.512000													4	37					0	0	1	0	0
OR2AG1	144125	broad.mit.edu	37	11	6807091	6807091	+	Missense_Mutation	SNP	T	T	A	rs112661648		TCGA-D6-A6EN-01A-11D-A31L-08	TCGA-D6-A6EN-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	971ca2bc-cd7b-4ce1-a471-81445b85e3a4	20f2c75b-d578-4332-83cb-0e2307d84fff	g.chr11:6807091T>A	ENST00000307401.4	+	1	844	c.823T>A	c.(823-825)Tct>Act	p.S275T		NM_001004489.2	NP_001004489.1	Q9H205	O2AG1_HUMAN	olfactory receptor, family 2, subfamily AG, member 1	275					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(2)|lung(13)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	26		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)		Epithelial(150;2.19e-08)|BRCA - Breast invasive adenocarcinoma(625;0.129)		CAACATCATCTCTGTTTTCTA	0.498000													11	39					0	0	1	0	0
ZNF160	90338	broad.mit.edu	37	19	53573249	53573249	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D6-A6EN-01A-11D-A31L-08	TCGA-D6-A6EN-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	971ca2bc-cd7b-4ce1-a471-81445b85e3a4	20f2c75b-d578-4332-83cb-0e2307d84fff	g.chr19:53573249G>A	ENST00000601421.1	-	3	1306	c.430C>T	c.(430-432)Cag>Tag	p.Q144*	ZNF160_ENST00000418871.1_Nonsense_Mutation_p.Q180*|ZNF160_ENST00000429604.1_Nonsense_Mutation_p.Q180*|ZNF160_ENST00000599056.1_Nonsense_Mutation_p.Q180*			Q9HCG1	ZN160_HUMAN	zinc finger protein 160	180					hemopoiesis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(8)|lung(10)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	35				GBM - Glioblastoma multiforme(134;0.02)		ACTCCAAGCTGATTGTTCATA	0.403000													16	54					0	0	1	0	0
ITPR2	3709	broad.mit.edu	37	12	26874260	26874260	+	Missense_Mutation	SNP	T	T	A			TCGA-D6-A6EN-01A-11D-A31L-08	TCGA-D6-A6EN-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	971ca2bc-cd7b-4ce1-a471-81445b85e3a4	20f2c75b-d578-4332-83cb-0e2307d84fff	g.chr12:26874260T>A	ENST00000242737.5	-	6	540	c.541A>T	c.(541-543)Att>Ttt	p.I181F	ITPR2_ENST00000381340.3_Intron			Q14571	ITPR2_HUMAN	inositol 1,4,5-trisphosphate receptor, type 2	0	MIR 2.				activation of phospholipase C activity|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	integral to membrane|plasma membrane enriched fraction|platelet dense tubular network membrane|sarcoplasmic reticulum membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity		ETV6/ITPR2(2)	biliary_tract(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(16)|large_intestine(20)|liver(1)|lung(51)|ovary(5)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(5)|urinary_tract(3)	125	Colorectal(261;0.0847)					CCAAATTAAATCCAGAAGCTT	0.338000													3	11					0	0	1	0	0
NPAS3	64067	broad.mit.edu	37	14	34269411	34269411	+	Missense_Mutation	SNP	C	C	T			TCGA-D6-A6EN-01A-11D-A31L-08	TCGA-D6-A6EN-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	971ca2bc-cd7b-4ce1-a471-81445b85e3a4	20f2c75b-d578-4332-83cb-0e2307d84fff	g.chr14:34269411C>T	ENST00000346562.2	+	11	1876	c.1802C>T	c.(1801-1803)cCc>cTc	p.P601L	NPAS3_ENST00000548645.1_Missense_Mutation_p.P603L|NPAS3_ENST00000551492.1_Missense_Mutation_p.P638L|NPAS3_ENST00000357798.5_Missense_Mutation_p.P620L|NPAS3_ENST00000356141.4_Missense_Mutation_p.P633L	NM_001164749.1|NM_001165893.1|NM_022123.2|NM_173159.2	NP_001158221.1|NP_001159365.1|NP_071406.1|NP_775182.1	Q8IXF0	NPAS3_HUMAN	neuronal PAS domain protein 3	633					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|signal transducer activity			breast(4)|endometrium(3)|kidney(1)|large_intestine(6)|liver(2)|lung(14)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	40	Breast(36;0.0102)|Hepatocellular(127;0.133)		LUAD - Lung adenocarcinoma(48;0.00169)|Lung(238;0.00968)	GBM - Glioblastoma multiforme(1;1.31e-09)|all cancers(1;0.000112)|OV - Ovarian serous cystadenocarcinoma(311;0.115)		CTGGTGGAGCCCCCGCGGCTG	0.652000													6	20					0	0	1	0	0
LACTB2	51110	broad.mit.edu	37	8	71570088	71570088	+	Missense_Mutation	SNP	G	G	A			TCGA-D6-A6EN-01A-11D-A31L-08	TCGA-D6-A6EN-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	971ca2bc-cd7b-4ce1-a471-81445b85e3a4	20f2c75b-d578-4332-83cb-0e2307d84fff	g.chr8:71570088G>A	ENST00000276590.4	-	3	352	c.316C>T	c.(316-318)Cgg>Tgg	p.R106W	RP11-382J12.1_ENST00000499227.2_Intron|LACTB2_ENST00000522447.1_Missense_Mutation_p.R106W	NM_016027.2	NP_057111.1	Q53H82	LACB2_HUMAN	lactamase, beta 2	106							hydrolase activity|metal ion binding			endometrium(2)|large_intestine(1)|liver(1)|lung(4)|ovary(1)|prostate(1)	10	Breast(64;0.0716)		Epithelial(68;0.00319)|all cancers(69;0.0175)|OV - Ovarian serous cystadenocarcinoma(28;0.0628)|BRCA - Breast invasive adenocarcinoma(89;0.166)			TGAGGATTCCGTGGGAGTTTT	0.323000													23	22					0	0	1	0	0
APBA1	320	broad.mit.edu	37	9	72131431	72131431	+	Silent	SNP	G	G	A			TCGA-D6-A6EN-01A-11D-A31L-08	TCGA-D6-A6EN-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	971ca2bc-cd7b-4ce1-a471-81445b85e3a4	20f2c75b-d578-4332-83cb-0e2307d84fff	g.chr9:72131431G>A	ENST00000265381.4	-	2	918	c.696C>T	c.(694-696)ggC>ggT	p.G232G		NM_001163.3	NP_001154.2	Q02410	APBA1_HUMAN	amyloid beta (A4) precursor protein-binding, family A, member 1	232	Munc-18-1 binding.				axon cargo transport|cell adhesion|intracellular protein transport|nervous system development|protein complex assembly|synaptic transmission	synaptic vesicle				endometrium(4)|kidney(2)|large_intestine(12)|lung(13)|prostate(3)|skin(3)	37						GCAGCCGCGCGCCCAGGGCCT	0.726000													5	17					0	0	1	0	0
PHOX2B	8929	broad.mit.edu	37	4	41749390	41749390	+	Silent	SNP	G	G	A	rs147497096		TCGA-D6-A6EN-01A-11D-A31L-08	TCGA-D6-A6EN-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	971ca2bc-cd7b-4ce1-a471-81445b85e3a4	20f2c75b-d578-4332-83cb-0e2307d84fff	g.chr4:41749390G>A	ENST00000226382.2	-	2	764	c.405C>T	c.(403-405)atC>atT	p.I135I		NM_003924.3	NP_003915.2	Q99453	PHX2B_HUMAN	paired-like homeobox 2b	135					positive regulation of transcription from RNA polymerase II promoter	nuclear chromatin	RNA polymerase II regulatory region sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription cofactor activity			autonomic_ganglia(7)|central_nervous_system(1)|endometrium(2)|large_intestine(5)|lung(11)|ovary(2)|skin(1)|urinary_tract(1)	30						CTGTGAGGTCGATCTTCAGGG	0.647000			"""Mis, F"""		neuroblastoma	neuroblastoma	congenital central hypoventilation syndrome		Neuroblastoma, Familial Clustering of;Congenital Central Hypoventilation Syndrome				20	46					0	0	1	0	0
WDR59	79726	broad.mit.edu	37	16	74927661	74927661	+	Missense_Mutation	SNP	C	C	T			TCGA-D6-A6EN-01A-11D-A31L-08	TCGA-D6-A6EN-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	971ca2bc-cd7b-4ce1-a471-81445b85e3a4	20f2c75b-d578-4332-83cb-0e2307d84fff	g.chr16:74927661C>T	ENST00000262144.6	-	19	2046	c.1916G>A	c.(1915-1917)cGa>cAa	p.R639Q		NM_030581.3	NP_085058.3	Q6PJI9	WDR59_HUMAN	WD repeat domain 59	639										breast(3)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(13)|ovary(1)|prostate(1)	27						CTTGATCTGTCGATTGCCAGA	0.458000													34	74					0	0	1	0	0
SPECC1L	23384	broad.mit.edu	37	22	24717411	24717411	+	Missense_Mutation	SNP	C	C	T	rs148203655		TCGA-D6-A6EN-01A-11D-A31L-08	TCGA-D6-A6EN-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	971ca2bc-cd7b-4ce1-a471-81445b85e3a4	20f2c75b-d578-4332-83cb-0e2307d84fff	g.chr22:24717411C>T	ENST00000314328.9	+	5	748	c.463C>T	c.(463-465)Cgc>Tgc	p.R155C	SPECC1L_ENST00000437398.1_Missense_Mutation_p.R155C|KB-1896H10.1_ENST00000358654.2_Missense_Mutation_p.R155C|SPECC1L_ENST00000541492.1_Missense_Mutation_p.R155C|SPECC1L_ENST00000416735.1_Intron	NM_001254733.1|NM_015330.3	NP_001241662.1|NP_056145.3	Q69YQ0	CYTSA_HUMAN	sperm antigen with calponin homology and coiled-coil domains 1-like	155					cell cycle|cell division					breast(1)|endometrium(1)|kidney(4)|large_intestine(7)|lung(6)|ovary(1)|prostate(1)|skin(3)|stomach(2)|urinary_tract(1)	27						CAAACGTTCCCGCAGTCGAAC	0.463000													27	77					0	0	1	0	0
ARAP3	64411	broad.mit.edu	37	5	141035785	141035785	+	Missense_Mutation	SNP	C	C	T			TCGA-D6-A6EN-01A-11D-A31L-08	TCGA-D6-A6EN-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	971ca2bc-cd7b-4ce1-a471-81445b85e3a4	20f2c75b-d578-4332-83cb-0e2307d84fff	g.chr5:141035785C>T	ENST00000239440.4	-	28	3913	c.3848G>A	c.(3847-3849)cGc>cAc	p.R1283H	ARAP3_ENST00000508305.1_Missense_Mutation_p.R1114H|ARAP3_ENST00000512390.1_5'UTR|ARAP3_ENST00000513878.1_Missense_Mutation_p.R945H	NM_022481.5	NP_071926.4	Q8WWN8	ARAP3_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3	1283	PH 3.				cytoskeleton organization|negative regulation of cell migration|negative regulation of Rho protein signal transduction|regulation of ARF GTPase activity|regulation of cell shape|small GTPase mediated signal transduction|vesicle-mediated transport	cytoskeleton|cytosol|lamellipodium|plasma membrane|ruffle	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|Rho GTPase activator activity|zinc ion binding			NS(1)|breast(7)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|lung(14)|ovary(1)|prostate(2)|skin(4)|stomach(1)	53						TAACTTCTTGCGGATTCCCAG	0.557000													4	116					0	0	1	0	0
ATP2B3	492	broad.mit.edu	37	X	152801884	152801884	+	Missense_Mutation	SNP	G	G	T			TCGA-D6-A6EN-01A-11D-A31L-08	TCGA-D6-A6EN-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	971ca2bc-cd7b-4ce1-a471-81445b85e3a4	20f2c75b-d578-4332-83cb-0e2307d84fff	g.chrX:152801884G>T	ENST00000370186.1	+	2	505	c.179G>T	c.(178-180)tGc>tTc	p.C60F	ATP2B3_ENST00000370181.2_Missense_Mutation_p.C60F|ATP2B3_ENST00000349466.2_Missense_Mutation_p.C60F|ATP2B3_ENST00000359149.3_Missense_Mutation_p.C60F|ATP2B3_ENST00000393842.1_Missense_Mutation_p.C60F|ATP2B3_ENST00000263519.4_Missense_Mutation_p.C60F			Q16720	AT2B3_HUMAN	ATPase, Ca++ transporting, plasma membrane 3	60					ATP biosynthetic process|platelet activation	integral to membrane|plasma membrane	ATP binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding			NS(2)|breast(5)|endometrium(7)|large_intestine(8)|lung(23)|ovary(1)|pancreas(1)|skin(3)	50	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					AGCGGGCTCTGCCGGAGGCTG	0.662000													2	2					1	1	1	1	0
ITPKC	80271	broad.mit.edu	37	19	41223947	41223947	+	Silent	SNP	T	T	C			TCGA-D6-A6EN-01A-11D-A31L-08	TCGA-D6-A6EN-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	971ca2bc-cd7b-4ce1-a471-81445b85e3a4	20f2c75b-d578-4332-83cb-0e2307d84fff	g.chr19:41223947T>C	ENST00000263370.2	+	1	940	c.907T>C	c.(907-909)Tta>Cta	p.L303L		NM_025194.2	NP_079470.1	Q96DU7	IP3KC_HUMAN	inositol-trisphosphate 3-kinase C	303						cytoplasm|nucleus	ATP binding|calmodulin binding|inositol trisphosphate 3-kinase activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(7)|ovary(1)|prostate(1)	14			LUSC - Lung squamous cell carcinoma(20;0.000219)|Lung(22;0.000959)			GGATGGCCCATTAGAGGAACC	0.572000													15	52					0	0	1	0	0
CENPF	1063	broad.mit.edu	37	1	214830486	214830486	+	Missense_Mutation	SNP	G	G	A			TCGA-D6-A6EN-01A-11D-A31L-08	TCGA-D6-A6EN-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	971ca2bc-cd7b-4ce1-a471-81445b85e3a4	20f2c75b-d578-4332-83cb-0e2307d84fff	g.chr1:214830486G>A	ENST00000366955.3	+	18	8864	c.8696G>A	c.(8695-8697)gGg>gAg	p.G2899E		NM_016343.3	NP_057427.3	P49454	CENPF_HUMAN	centromere protein F, 350/400kDa	2995	Sufficient for centromere localization.|Sufficient for self-association.				cell differentiation|cell division|cell proliferation|DNA replication|G2 phase of mitotic cell cycle|kinetochore assembly|metaphase plate congression|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|muscle organ development|negative regulation of transcription, DNA-dependent|protein transport|regulation of G2/M transition of mitotic cell cycle|regulation of striated muscle tissue development|response to drug	condensed chromosome outer kinetochore|cytosol|midbody|nuclear envelope|nuclear matrix|perinuclear region of cytoplasm|spindle pole	chromatin binding|dynein binding|protein C-terminus binding|protein homodimerization activity|transcription factor binding			NS(2)|breast(2)|central_nervous_system(4)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(37)|lung(47)|ovary(7)|prostate(3)|skin(6)|stomach(1)|urinary_tract(1)	126				all cancers(67;0.00836)|OV - Ovarian serous cystadenocarcinoma(81;0.00855)|GBM - Glioblastoma multiforme(131;0.0694)|Epithelial(68;0.0833)		GATTCCCGAGGGTCTCCTTTG	0.438000													37	105					0	0	1	0	0
BOLL	66037	broad.mit.edu	37	2	198646521	198646521	+	Silent	SNP	C	C	T			TCGA-D6-A6EN-01A-11D-A31L-08	TCGA-D6-A6EN-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	971ca2bc-cd7b-4ce1-a471-81445b85e3a4	20f2c75b-d578-4332-83cb-0e2307d84fff	g.chr2:198646521C>T	ENST00000321801.7	-	2	660	c.90G>A	c.(88-90)ttG>ttA	p.L30L	BOLL_ENST00000392296.4_Silent_p.L18L|BOLL_ENST00000430004.1_Silent_p.L18L|BOLL_ENST00000433157.1_Silent_p.L18L|BOLL_ENST00000282278.8_5'UTR	NM_197970.2	NP_932074.1	Q8N9W6	BOLL_HUMAN	boule-like RNA-binding protein	18					cell differentiation|meiosis|multicellular organismal development|positive regulation of translational initiation|spermatogenesis	cytoplasm	nucleotide binding|protein binding|RNA binding|translation activator activity			central_nervous_system(1)|endometrium(2)|lung(6)|ovary(3)|prostate(1)	13						TTGGGTTATTCAAAGGCACAG	0.378000													26	111					0	0	1	0	0
FNBP4	23360	broad.mit.edu	37	11	47776172	47776172	+	Missense_Mutation	SNP	C	C	A			TCGA-D6-A6EN-01A-11D-A31L-08	TCGA-D6-A6EN-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	971ca2bc-cd7b-4ce1-a471-81445b85e3a4	20f2c75b-d578-4332-83cb-0e2307d84fff	g.chr11:47776172C>A	ENST00000263773.5	-	3	370	c.358G>T	c.(358-360)Gac>Tac	p.D120Y	FNBP4_ENST00000534003.1_5'UTR	NM_015308.2	NP_056123.2	Q8N3X1	FNBP4_HUMAN	formin binding protein 4	120										NS(1)|breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|lung(12)|ovary(3)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	44						ACATCATTGTCATCGTCATCA	0.393000													7	48					8.12818e-05	8.54048e-05	1	1	0
SLITRK2	84631	broad.mit.edu	37	X	144904872	144904872	+	Missense_Mutation	SNP	G	G	A			TCGA-D6-A6EN-01A-11D-A31L-08	TCGA-D6-A6EN-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	971ca2bc-cd7b-4ce1-a471-81445b85e3a4	20f2c75b-d578-4332-83cb-0e2307d84fff	g.chrX:144904872G>A	ENST00000370490.1	+	1	5184	c.929G>A	c.(928-930)cGt>cAt	p.R310H	SLITRK2_ENST00000428560.2_Missense_Mutation_p.R310H|SLITRK2_ENST00000447897.2_Missense_Mutation_p.R310H|SLITRK2_ENST00000434188.2_Missense_Mutation_p.R310H|SLITRK2_ENST00000413937.2_Missense_Mutation_p.R310H			Q9H156	SLIK2_HUMAN	SLIT and NTRK-like family, member 2	310						integral to membrane				NS(1)|breast(3)|central_nervous_system(1)|endometrium(9)|kidney(1)|large_intestine(17)|lung(40)|ovary(5)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	86	Acute lymphoblastic leukemia(192;6.56e-05)					ATGAGAAATCGTCCAACTCCT	0.552000													19	20					0	0	1	0	0
NEUROD4	58158	broad.mit.edu	37	12	55420807	55420807	+	Missense_Mutation	SNP	C	C	T			TCGA-D6-A6EN-01A-11D-A31L-08	TCGA-D6-A6EN-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	971ca2bc-cd7b-4ce1-a471-81445b85e3a4	20f2c75b-d578-4332-83cb-0e2307d84fff	g.chr12:55420807C>T	ENST00000242994.3	+	2	962	c.584C>T	c.(583-585)tCt>tTt	p.S195F		NM_021191.2	NP_067014.2	Q9HD90	NDF4_HUMAN	neuronal differentiation 4	195					amacrine cell differentiation|positive regulation of cell differentiation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(14)|ovary(3)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)	41						ATTTGTGACTCTGCCATCTCT	0.517000													17	40					0	0	1	0	0
ZMYM3	9203	broad.mit.edu	37	X	70466245	70466245	+	Missense_Mutation	SNP	C	C	T			TCGA-D6-A6EN-01A-11D-A31L-08	TCGA-D6-A6EN-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	971ca2bc-cd7b-4ce1-a471-81445b85e3a4	20f2c75b-d578-4332-83cb-0e2307d84fff	g.chrX:70466245C>T	ENST00000373998.1	-	15	3191	c.2494G>A	c.(2494-2496)Gtc>Atc	p.V832I	ZMYM3_ENST00000314425.5_Missense_Mutation_p.V844I|ZMYM3_ENST00000373988.1_Missense_Mutation_p.V846I|ZMYM3_ENST00000353904.2_Missense_Mutation_p.V844I|ZMYM3_ENST00000489332.1_5'UTR|ZMYM3_ENST00000373984.3_Missense_Mutation_p.V846I	NM_001171162.1	NP_001164633.1	Q14202	ZMYM3_HUMAN	zinc finger, MYM-type 3	844					multicellular organismal development	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(7)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(12)|lung(17)|ovary(1)|prostate(9)|upper_aerodigestive_tract(1)|urinary_tract(1)	64	Renal(35;0.156)					TTGCAGGAGACGCCCCGATTC	0.592000													10	13					0	0	1	0	0
OR4X2	119764	broad.mit.edu	37	11	48267105	48267105	+	Silent	SNP	A	A	G			TCGA-D6-A6EN-01A-11D-A31L-08	TCGA-D6-A6EN-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	971ca2bc-cd7b-4ce1-a471-81445b85e3a4	20f2c75b-d578-4332-83cb-0e2307d84fff	g.chr11:48267105A>G	ENST00000302329.3	+	1	498	c.450A>G	c.(448-450)gcA>gcG	p.A150A		NM_001004727.1	NP_001004727.1	Q8NGF9	OR4X2_HUMAN	olfactory receptor, family 4, subfamily X, member 2	150					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|large_intestine(4)|lung(12)|pancreas(1)|stomach(1)|upper_aerodigestive_tract(1)	20						ATTCCTTTGCACAAATCCTTC	0.498000													31	115					0	0	1	0	0
LRWD1	222229	broad.mit.edu	37	7	102106340	102106340	+	Missense_Mutation	SNP	G	G	T			TCGA-D6-A6EN-01A-11D-A31L-08	TCGA-D6-A6EN-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	971ca2bc-cd7b-4ce1-a471-81445b85e3a4	20f2c75b-d578-4332-83cb-0e2307d84fff	g.chr7:102106340G>T	ENST00000292616.5	+	2	309	c.157G>T	c.(157-159)Gac>Tac	p.D53Y		NM_152892.1	NP_690852.1	Q9UFC0	LRWD1_HUMAN	leucine-rich repeats and WD repeat domain containing 1	53					chromatin modification|DNA-dependent DNA replication initiation|establishment of protein localization to chromatin|G1 phase of mitotic cell cycle	centromeric heterochromatin|nuclear origin of replication recognition complex|telomeric heterochromatin	chromatin binding|methyl-CpG binding|methylated histone residue binding			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(7)|ovary(1)|skin(1)|stomach(2)	20						GCAGGAGCTTGACCTGTCTAA	0.622000													13	49					4.3838e-07	4.74367e-07	1	1	0
PCCA	5095	broad.mit.edu	37	13	100955251	100955251	+	Splice_Site	SNP	G	G	C			TCGA-D6-A6EN-01A-11D-A31L-08	TCGA-D6-A6EN-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	971ca2bc-cd7b-4ce1-a471-81445b85e3a4	20f2c75b-d578-4332-83cb-0e2307d84fff	g.chr13:100955251G>C	ENST00000376285.1	+	14	1321	c.1284_splice	c.e14+1	p.G428_splice	PCCA_ENST00000376279.3_Splice_Site_p.G428_splice|PCCA_ENST00000376286.4_Splice_Site_p.G402_splice	NM_000282.3	NP_000273.2	P05165	PCCA_HUMAN	propionyl CoA carboxylase, alpha polypeptide	428	Biotin carboxylation.				fatty acid beta-oxidation	mitochondrial matrix	ATP binding|biotin binding|biotin carboxylase activity|enzyme binding|metal ion binding|propionyl-CoA carboxylase activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(12)|lung(8)|prostate(1)|skin(2)	26	all_neural(89;0.0837)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)				Biotin(DB00121)	CATCTACCTGGTGTAAGTCAT	0.383000													7	32					0	0	1	0	0
TMOD1	7111	broad.mit.edu	37	9	100328229	100328229	+	Missense_Mutation	SNP	G	G	A			TCGA-D6-A6EN-01A-11D-A31L-08	TCGA-D6-A6EN-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	971ca2bc-cd7b-4ce1-a471-81445b85e3a4	20f2c75b-d578-4332-83cb-0e2307d84fff	g.chr9:100328229G>A	ENST00000395211.2	+	7	854	c.718G>A	c.(718-720)Gtg>Atg	p.V240M	TMOD1_ENST00000259365.3_Missense_Mutation_p.V240M|TMOD1_ENST00000375175.1_Missense_Mutation_p.V113M	NM_001166116.1	NP_001159588.1	P28289	TMOD1_HUMAN	tropomodulin 1	240					muscle filament sliding	cytosol	actin binding			breast(1)|central_nervous_system(1)|kidney(3)|large_intestine(3)|lung(2)|urinary_tract(1)	11		Acute lymphoblastic leukemia(62;0.154)		STAD - Stomach adenocarcinoma(157;0.105)		TAATGACCCCGTGGCGTATGT	0.493000													16	64					0	0	1	0	0
BCRP7	100133163	broad.mit.edu	37	22	18846098	18846098	+	RNA	SNP	G	G	A	rs9306211		TCGA-D6-A6EN-01A-11D-A31L-08	TCGA-D6-A6EN-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	971ca2bc-cd7b-4ce1-a471-81445b85e3a4	20f2c75b-d578-4332-83cb-0e2307d84fff	g.chr22:18846098G>A	ENST00000412938.1	+	0	3456																											ATGCCTCGGCGCTCGATCTCC	0.622000													7	27					0	0	1	0	0
NALCN	259232	broad.mit.edu	37	13	101844291	101844291	+	Missense_Mutation	SNP	G	G	C			TCGA-D6-A6EN-01A-11D-A31L-08	TCGA-D6-A6EN-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	971ca2bc-cd7b-4ce1-a471-81445b85e3a4	20f2c75b-d578-4332-83cb-0e2307d84fff	g.chr13:101844291G>C	ENST00000251127.6	-	14	1822	c.1741C>G	c.(1741-1743)Ctc>Gtc	p.L581V	NALCN_ENST00000376196.3_Missense_Mutation_p.L581V|NALCN_ENST00000470333.1_5'UTR	NM_052867.2	NP_443099.1	Q8IZF0	NALCN_HUMAN	sodium leak channel, non-selective	581						integral to membrane	sodium channel activity|voltage-gated ion channel activity			NS(1)|autonomic_ganglia(2)|breast(6)|central_nervous_system(2)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(33)|liver(2)|lung(81)|ovary(8)|pancreas(3)|prostate(5)|skin(6)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	177	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					AGATGATAGAGAATGAAATAG	0.413000													5	20					0	0	1	0	0
GJB3	2707	broad.mit.edu	37	1	35250780	35250780	+	Silent	SNP	C	C	T			TCGA-D6-A6EN-01A-11D-A31L-08	TCGA-D6-A6EN-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	971ca2bc-cd7b-4ce1-a471-81445b85e3a4	20f2c75b-d578-4332-83cb-0e2307d84fff	g.chr1:35250780C>T	ENST00000373366.2	+	2	1032	c.417C>T	c.(415-417)ctC>ctT	p.L139L	GJB3_ENST00000373362.3_Silent_p.L139L|RP1-34M23.5_ENST00000542839.1_RNA	NM_024009.2	NP_076872.1	O75712	CXB3_HUMAN	gap junction protein, beta 3, 31kDa	139					cell communication	connexon complex|integral to membrane	gap junction channel activity			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(2)|prostate(3)	15		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.234)				TCTTCAAGCTCATCATTGAGT	0.587000													25	81					0	0	1	0	0
TAS2R13	50838	broad.mit.edu	37	12	11061430	11061430	+	Silent	SNP	C	C	T			TCGA-D6-A6EN-01A-11D-A31L-08	TCGA-D6-A6EN-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	971ca2bc-cd7b-4ce1-a471-81445b85e3a4	20f2c75b-d578-4332-83cb-0e2307d84fff	g.chr12:11061430C>T	ENST00000390677.2	-	1	731	c.468G>A	c.(466-468)ctG>ctA	p.L156L	PRR4_ENST00000536668.1_Intron	NM_023920.2	NP_076409.1	Q9NYV9	T2R13_HUMAN	taste receptor, type 2, member 13	156					sensory perception of taste	integral to membrane	taste receptor activity			breast(1)|endometrium(1)|large_intestine(4)|lung(2)|skin(1)	9						CATATCGGTCCAGCCAGTCTT	0.348000													13	36					0	0	1	0	0
SHB	6461	broad.mit.edu	37	9	37974673	37974673	+	Missense_Mutation	SNP	C	C	T			TCGA-D6-A6EN-01A-11D-A31L-08	TCGA-D6-A6EN-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	971ca2bc-cd7b-4ce1-a471-81445b85e3a4	20f2c75b-d578-4332-83cb-0e2307d84fff	g.chr9:37974673C>T	ENST00000377707.3	-	3	1565	c.1000G>A	c.(1000-1002)Gat>Aat	p.D334N	RP11-613M10.9_ENST00000540557.1_3'UTR	NM_003028.2	NP_003019.2	Q15464	SHB_HUMAN	Src homology 2 domain containing adaptor protein B	334	Mediates interaction with LAT, FAK1, JAK1 and JAK3.				angiogenesis|apoptosis|cell differentiation|signal transduction	cytoplasm|plasma membrane	SH3/SH2 adaptor activity			central_nervous_system(2)|endometrium(4)|lung(1)|prostate(1)|skin(1)|soft_tissue(1)|stomach(1)	11		all_epithelial(88;0.122)		GBM - Glioblastoma multiforme(29;3.27e-05)|Lung(182;0.0658)		TCGTACTCATCGGCGGGCCTG	0.632000													31	76					0	0	1	0	0
HIST1H3B	8358	broad.mit.edu	37	6	26031885	26031885	+	Missense_Mutation	SNP	C	C	T			TCGA-D6-A6EN-01A-11D-A31L-08	TCGA-D6-A6EN-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	971ca2bc-cd7b-4ce1-a471-81445b85e3a4	20f2c75b-d578-4332-83cb-0e2307d84fff	g.chr6:26031885C>T	ENST00000244661.2	-	1	403	c.404G>A	c.(403-405)aGa>aAa	p.R135K		NM_003537.3	NP_003528.1	P68431	H31_HUMAN	histone cluster 1, H3b	135				Missing (in Ref. 2; AAA52651).	blood coagulation|nucleosome assembly|regulation of gene silencing|S phase	nucleoplasm|nucleosome	DNA binding|protein binding			breast(3)|central_nervous_system(10)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(4)|ovary(2)|skin(1)	25						CATTTACGCTCTTTCTCCGCG	0.453000													25	56					0	0	1	0	0
TAF1L	138474	broad.mit.edu	37	9	32631389	32631389	+	Missense_Mutation	SNP	G	G	A			TCGA-D6-A6EN-01A-11D-A31L-08	TCGA-D6-A6EN-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	971ca2bc-cd7b-4ce1-a471-81445b85e3a4	20f2c75b-d578-4332-83cb-0e2307d84fff	g.chr9:32631389G>A	ENST00000242310.4	-	1	4278	c.4189C>T	c.(4189-4191)Cgc>Tgc	p.R1397C		NM_153809.2	NP_722516.1	Q8IZX4	TAF1L_HUMAN	TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 210kDa-like	1397					male meiosis|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription initiation, DNA-dependent	transcription factor TFIID complex	DNA binding|histone acetyltransferase activity|protein serine/threonine kinase activity|TBP-class protein binding			breast(6)|central_nervous_system(4)|endometrium(14)|kidney(11)|large_intestine(32)|liver(2)|lung(68)|ovary(2)|pancreas(2)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(1)	159			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.00301)		GGGTCTGTGCGGCGTCGGTGG	0.468000													77	123					0	0	1	0	0
NCKAP5	344148	broad.mit.edu	37	2	133543010	133543010	+	Silent	SNP	C	C	G			TCGA-D6-A6EN-01A-11D-A31L-08	TCGA-D6-A6EN-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	971ca2bc-cd7b-4ce1-a471-81445b85e3a4	20f2c75b-d578-4332-83cb-0e2307d84fff	g.chr2:133543010C>G	ENST00000409261.1	-	14	1747	c.1374G>C	c.(1372-1374)ggG>ggC	p.G458G	NCKAP5_ENST00000317721.6_Silent_p.G458G|NCKAP5_ENST00000409213.1_Intron|NCKAP5_ENST00000405974.3_Intron	NM_207363.2	NP_997246.2	O14513	NCKP5_HUMAN	NCK-associated protein 5	458							protein binding			NS(4)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(29)|lung(51)|prostate(5)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	118						TGCAGGGGCTCCCCAGGTCAG	0.468000													14	11					0	0	1	0	0
VAPA	9218	broad.mit.edu	37	18	9936135	9936135	+	Silent	SNP	G	G	A			TCGA-D6-A6EN-01A-11D-A31L-08	TCGA-D6-A6EN-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	971ca2bc-cd7b-4ce1-a471-81445b85e3a4	20f2c75b-d578-4332-83cb-0e2307d84fff	g.chr18:9936135G>A	ENST00000400000.2	+	3	516	c.261G>A	c.(259-261)ccG>ccA	p.P87P	VAPA_ENST00000340541.4_Silent_p.P87P|VAPA_ENST00000584796.1_3'UTR	NM_003574.5|NM_194434.2	NP_003565.4|NP_919415.2	Q9P0L0	VAPA_HUMAN	VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa	87	MSP.				cell death|cellular membrane fusion|neuron projection development|positive regulation of I-kappaB kinase/NF-kappaB cascade|protein localization in endoplasmic reticulum|sphingolipid metabolic process	endoplasmic reticulum membrane|integral to membrane|plasma membrane|vesicle	protein heterodimerization activity|signal transducer activity|structural molecule activity			breast(1)|lung(2)|prostate(1)	4						ACTATGATCCGAATGAAAAGA	0.333000													5	56					0	0	1	0	0
DESI1	27351	broad.mit.edu	37	22	41999360	41999360	+	Missense_Mutation	SNP	G	G	A			TCGA-D6-A6EN-01A-11D-A31L-08	TCGA-D6-A6EN-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	971ca2bc-cd7b-4ce1-a471-81445b85e3a4	20f2c75b-d578-4332-83cb-0e2307d84fff	g.chr22:41999360G>A	ENST00000263256.6	-	5	572	c.316C>T	c.(316-318)Cac>Tac	p.H106Y	DESI1_ENST00000463886.1_5'UTR	NM_015704.2	NP_056519.1	Q6ICB0	PPDE2_HUMAN	desumoylating isopeptidase 1	106	PPPDE peptidase.																TTACAATTGTGTTCAAAGAGG	0.463000													29	89					0	0	1	0	0
SLC4A5	57835	broad.mit.edu	37	2	74459765	74459765	+	Missense_Mutation	SNP	C	C	T			TCGA-D6-A6EN-01A-11D-A31L-08	TCGA-D6-A6EN-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	971ca2bc-cd7b-4ce1-a471-81445b85e3a4	20f2c75b-d578-4332-83cb-0e2307d84fff	g.chr2:74459765C>T	ENST00000394019.2	-	24	3002	c.2605G>A	c.(2605-2607)Ggc>Agc	p.G869S	RP11-287D1.3_ENST00000451608.2_3'UTR|SLC4A5_ENST00000423644.1_Intron|SLC4A5_ENST00000377632.1_Missense_Mutation_p.G869S|SLC4A5_ENST00000377634.4_Missense_Mutation_p.G869S|SLC4A5_ENST00000359484.4_Missense_Mutation_p.G767S|SLC4A5_ENST00000483195.1_Intron|SLC4A5_ENST00000358683.4_Missense_Mutation_p.G767S|SLC4A5_ENST00000357822.5_Missense_Mutation_p.G869S|SLC4A5_ENST00000346834.4_Missense_Mutation_p.G869S	NM_133478.2	NP_597812.1	Q9BY07	S4A5_HUMAN	solute carrier family 4 (sodium bicarbonate cotransporter), member 5	869						apical plasma membrane|integral to membrane	inorganic anion exchanger activity|sodium:bicarbonate symporter activity			breast(5)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(12)|lung(13)|ovary(5)|pancreas(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	48						AGATGGTAGCCGGCAGCCTTC	0.602000													6	35					0	0	1	0	0
EPHB6	2051	broad.mit.edu	37	7	142562010	142562010	+	Missense_Mutation	SNP	G	G	A	rs145358081	byFrequency	TCGA-D6-A6EN-01A-11D-A31L-08	TCGA-D6-A6EN-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	971ca2bc-cd7b-4ce1-a471-81445b85e3a4	20f2c75b-d578-4332-83cb-0e2307d84fff	g.chr7:142562010G>A	ENST00000392957.2	+	7	1239	c.452G>A	c.(451-453)cGc>cAc	p.R151H	EPHB6_ENST00000442129.1_Missense_Mutation_p.R151H|EPHB6_ENST00000411471.2_Intron	NM_004445.3	NP_004436.2	O15197	EPHB6_HUMAN	EPH receptor B6	151						extracellular region|integral to plasma membrane	ATP binding|ephrin receptor activity			NS(1)|breast(1)|central_nervous_system(4)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(9)|lung(46)|ovary(2)|pancreas(2)|prostate(1)|skin(9)|stomach(1)|upper_aerodigestive_tract(1)	87	Melanoma(164;0.059)					CACCTCAAACGCTGGACCAAG	0.627000													27	67					0	0	1	0	0
TRIP12	9320	broad.mit.edu	37	2	230643687	230643687	+	Missense_Mutation	SNP	G	G	T			TCGA-D6-A6EN-01A-11D-A31L-08	TCGA-D6-A6EN-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	971ca2bc-cd7b-4ce1-a471-81445b85e3a4	20f2c75b-d578-4332-83cb-0e2307d84fff	g.chr2:230643687G>T	ENST00000283943.5	-	34	5067	c.4889C>A	c.(4888-4890)cCt>cAt	p.P1630H	TRIP12_ENST00000389045.3_Missense_Mutation_p.P1360H|TRIP12_ENST00000389044.4_Missense_Mutation_p.P1678H	NM_004238.1	NP_004229.1	Q14669	TRIPC_HUMAN	thyroid hormone receptor interactor 12	1630					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	proteasome complex	thyroid hormone receptor binding|ubiquitin-protein ligase activity			breast(2)|central_nervous_system(4)|cervix(1)|endometrium(5)|kidney(6)|large_intestine(19)|lung(32)|ovary(5)|prostate(4)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	87		Renal(207;0.025)|all_hematologic(139;0.122)|all_lung(227;0.126)|Acute lymphoblastic leukemia(138;0.164)		Epithelial(121;4.76e-13)|all cancers(144;4.34e-10)|LUSC - Lung squamous cell carcinoma(224;0.00864)|Lung(119;0.0116)		CTCCAGTGTAGGCCCAAGACC	0.408000													25	90					3.28513e-13	3.63621e-13	1	1	0
USP6	9098	broad.mit.edu	37	17	5064823	5064823	+	Splice_Site	SNP	T	T	A			TCGA-D6-A6EN-01A-11D-A31L-08	TCGA-D6-A6EN-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	971ca2bc-cd7b-4ce1-a471-81445b85e3a4	20f2c75b-d578-4332-83cb-0e2307d84fff	g.chr17:5064823T>A	ENST00000574788.1	+	32	5059	c.2828_splice	c.e32-1	p.R943_splice	USP6_ENST00000304328.5_Splice_Site_p.R626_splice|USP6_ENST00000250066.6_Splice_Site_p.R943_splice|USP6_ENST00000332776.4_3'UTR			P35125	UBP6_HUMAN	ubiquitin specific peptidase 6 (Tre-2 oncogene)	943					protein deubiquitination|regulation of vesicle-mediated transport|ubiquitin-dependent protein catabolic process	lysosome|plasma membrane|recycling endosome	calmodulin binding|cysteine-type endopeptidase activity|nucleic acid binding|protein binding|Rab GTPase activator activity|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(4)|lung(15)|ovary(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	34						TCTGTTTCAGTGATAACTGTA	0.433000			T	"""COL1A1, CDH11, ZNF9, OMD"""	aneurysmal bone cysts								8	15					0	0	1	0	0
ATE1	11101	broad.mit.edu	37	10	123662084	123662084	+	Missense_Mutation	SNP	C	C	T			TCGA-D6-A6EN-01A-11D-A31L-08	TCGA-D6-A6EN-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	971ca2bc-cd7b-4ce1-a471-81445b85e3a4	20f2c75b-d578-4332-83cb-0e2307d84fff	g.chr10:123662084C>T	ENST00000369043.3	-	6	721	c.635G>A	c.(634-636)cGg>cAg	p.R212Q	ATE1_ENST00000369040.3_Missense_Mutation_p.R116Q|ATE1_ENST00000224652.6_Missense_Mutation_p.R212Q|ATE1_ENST00000535655.1_Intron|ATE1_ENST00000540606.1_Missense_Mutation_p.R205Q|ATE1_ENST00000543447.1_Missense_Mutation_p.R97Q	NM_007041.2	NP_008972.2	O95260	ATE1_HUMAN	arginyltransferase 1	212					protein arginylation	cytoplasm|nucleus	acyltransferase activity|arginyltransferase activity			endometrium(2)|kidney(2)|large_intestine(2)|lung(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	14		all_neural(114;0.061)|Lung NSC(174;0.095)|all_lung(145;0.124)|Breast(234;0.212)				CCTTTCTTTCCGGATTTCCTT	0.408000													10	24					0	0	1	0	0
CDH10	1008	broad.mit.edu	37	5	24491935	24491935	+	Splice_Site	SNP	A	A	G			TCGA-D6-A6EN-01A-11D-A31L-08	TCGA-D6-A6EN-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	971ca2bc-cd7b-4ce1-a471-81445b85e3a4	20f2c75b-d578-4332-83cb-0e2307d84fff	g.chr5:24491935A>G	ENST00000264463.4	-	11	2133	c.1624_splice	c.e11-1	p.D542_splice	CDH10_ENST00000502921.1_5'UTR	NM_006727.3	NP_006718.2	Q9Y6N8	CAD10_HUMAN	cadherin 10, type 2 (T2-cadherin)	542	Cadherin 5.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(29)|lung(111)|ovary(6)|pancreas(6)|skin(4)|stomach(2)|upper_aerodigestive_tract(4)	185				STAD - Stomach adenocarcinoma(35;0.0556)		TGGCAGTATTATCTAAAACAA	0.289000										HNSCC(23;0.051)			5	15					0	0	1	0	0
AURKC	6795	broad.mit.edu	37	19	57746758	57746758	+	Silent	SNP	G	G	T	rs140410966		TCGA-D6-A6EN-01A-11D-A31L-08	TCGA-D6-A6EN-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	971ca2bc-cd7b-4ce1-a471-81445b85e3a4	20f2c75b-d578-4332-83cb-0e2307d84fff	g.chr19:57746758G>T	ENST00000302804.7	+	7	1089	c.903G>T	c.(901-903)ctG>ctT	p.L301L	AURKC_ENST00000415300.2_Silent_p.L282L|AURKC_ENST00000448930.1_Silent_p.L267L|AURKC_ENST00000598785.1_Silent_p.L267L|AURKC_ENST00000599062.1_Silent_p.L298L	NM_001015878.1	NP_001015878.1	Q9UQB9	AURKC_HUMAN	aurora kinase C	301					cell cycle|cytokinesis	condensed chromosome|cytoplasm|midbody|spindle midzone	ATP binding|protein serine/threonine kinase activity			breast(1)|endometrium(1)|large_intestine(9)|lung(9)|ovary(3)|prostate(1)|stomach(1)	25		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0122)		GAAGGGTGCTGCCTCCCTGTG	0.577000													23	60					3.28513e-13	3.63621e-13	1	1	0
NEK10	152110	broad.mit.edu	37	3	27157603	27157603	+	Missense_Mutation	SNP	A	A	G	rs111622636		TCGA-D6-A6EN-01A-11D-A31L-08	TCGA-D6-A6EN-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	971ca2bc-cd7b-4ce1-a471-81445b85e3a4	20f2c75b-d578-4332-83cb-0e2307d84fff	g.chr3:27157603A>G	ENST00000429845.2	-	37	3739	c.3377T>C	c.(3376-3378)aTt>aCt	p.I1126T	NEK10_ENST00000295720.6_Missense_Mutation_p.I438T|NEK10_ENST00000383771.4_Missense_Mutation_p.I428T|NEK10_ENST00000383770.3_Missense_Mutation_p.I381T			Q6ZWH5	NEK10_HUMAN	NIMA-related kinase 10	1126							ATP binding|metal ion binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(2)|breast(1)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(9)|ovary(5)|pancreas(1)|prostate(1)|skin(4)|stomach(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	41						CTCCAATTCAATGCTGGTTGG	0.333000													7	25					0	0	1	0	0
KIAA1429	25962	broad.mit.edu	37	8	95504027	95504027	+	Missense_Mutation	SNP	C	C	T			TCGA-D6-A6EN-01A-11D-A31L-08	TCGA-D6-A6EN-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	971ca2bc-cd7b-4ce1-a471-81445b85e3a4	20f2c75b-d578-4332-83cb-0e2307d84fff	g.chr8:95504027C>T	ENST00000297591.5	-	22	4994	c.4919G>A	c.(4918-4920)cGt>cAt	p.R1640H	KIAA1429_ENST00000437199.1_3'UTR	NM_015496.4	NP_056311.2	Q69YN4	VIR_HUMAN	KIAA1429	1640					mRNA processing|RNA splicing	nucleus				NS(1)|breast(3)|central_nervous_system(1)|endometrium(4)|kidney(5)|large_intestine(16)|lung(28)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	66	Breast(36;3.29e-05)		BRCA - Breast invasive adenocarcinoma(8;0.00185)			TTTTCTCTGACGAAAAATATC	0.453000													17	86					0	0	1	0	0
ZNF629	23361	broad.mit.edu	37	16	30795057	30795057	+	Missense_Mutation	SNP	G	G	A			TCGA-D6-A6EN-01A-11D-A31L-08	TCGA-D6-A6EN-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	971ca2bc-cd7b-4ce1-a471-81445b85e3a4	20f2c75b-d578-4332-83cb-0e2307d84fff	g.chr16:30795057G>A	ENST00000262525.4	-	3	799	c.592C>T	c.(592-594)Cgc>Tgc	p.R198C		NM_001080417.1	NP_001073886.1	Q9UEG4	ZN629_HUMAN	zinc finger protein 629	198					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(8)|ovary(1)|prostate(3)|urinary_tract(1)	22			Colorectal(24;0.198)			GTGTGCGTGCGCTGGTGCTGC	0.672000													11	35					0	0	1	0	0
TNKS1BP1	85456	broad.mit.edu	37	11	57075893	57075893	+	Missense_Mutation	SNP	C	C	G			TCGA-D6-A6EN-01A-11D-A31L-08	TCGA-D6-A6EN-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	971ca2bc-cd7b-4ce1-a471-81445b85e3a4	20f2c75b-d578-4332-83cb-0e2307d84fff	g.chr11:57075893C>G	ENST00000532437.1	-	5	4603	c.4292G>C	c.(4291-4293)gGa>gCa	p.G1431A	TNKS1BP1_ENST00000358252.3_Missense_Mutation_p.G1431A			Q9C0C2	TB182_HUMAN	tankyrase 1 binding protein 1, 182kDa	1431	Acidic.				nuclear-transcribed mRNA poly(A) tail shortening|telomere maintenance via telomerase	cytoskeleton|cytosol|nuclear telomeric heterochromatin	ankyrin binding|enzyme binding			breast(3)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(11)|lung(24)|ovary(3)|prostate(3)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	64		all_epithelial(135;0.21)				GAGGGCTTCTCCTGTCTCCAT	0.567000													63	213					0	0	1	0	0
FAM53A	152877	broad.mit.edu	37	4	1657255	1657255	+	Missense_Mutation	SNP	G	G	A			TCGA-D6-A6EN-01A-11D-A31L-08	TCGA-D6-A6EN-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	971ca2bc-cd7b-4ce1-a471-81445b85e3a4	20f2c75b-d578-4332-83cb-0e2307d84fff	g.chr4:1657255G>A	ENST00000308132.6	-	4	524	c.332C>T	c.(331-333)tCg>tTg	p.S111L	FAM53A_ENST00000472884.2_Missense_Mutation_p.S111L|FAM53A_ENST00000461064.1_Missense_Mutation_p.S111L|FAM53A_ENST00000489363.1_Missense_Mutation_p.S111L	NM_001174070.1	NP_001167541.1	Q6NSI3	FA53A_HUMAN	family with sequence similarity 53, member A	111						nucleus				breast(2)|central_nervous_system(2)|large_intestine(1)|lung(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	10		all_epithelial(65;0.206)|Breast(71;0.212)	OV - Ovarian serous cystadenocarcinoma(23;0.0145)			GGCCGTGGACGAGCCTGTGCT	0.701000													5	9					0	0	1	0	0
RYR1	6261	broad.mit.edu	37	19	38976393	38976393	+	Missense_Mutation	SNP	G	G	A			TCGA-D6-A6EN-01A-11D-A31L-08	TCGA-D6-A6EN-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	971ca2bc-cd7b-4ce1-a471-81445b85e3a4	20f2c75b-d578-4332-83cb-0e2307d84fff	g.chr19:38976393G>A	ENST00000355481.4	+	34	5229	c.5098G>A	c.(5098-5100)Gcg>Acg	p.A1700T	RYR1_ENST00000360985.3_Missense_Mutation_p.A1700T|RYR1_ENST00000359596.3_Missense_Mutation_p.A1700T	NM_000540.2|NM_001042723.1	NP_000531.2|NP_001036188.1	P21817	RYR1_HUMAN	ryanodine receptor 1 (skeletal)	1700	6 X approximate repeats.				muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(4)|autonomic_ganglia(2)|breast(3)|central_nervous_system(5)|endometrium(26)|haematopoietic_and_lymphoid_tissue(3)|kidney(34)|large_intestine(42)|liver(1)|lung(106)|ovary(11)|pancreas(5)|prostate(9)|skin(12)|stomach(11)|upper_aerodigestive_tract(4)|urinary_tract(7)	285	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	CCTGGAGGACGCGCACCTGCC	0.657000													16	70					0	0	1	0	0
ANKRD29	147463	broad.mit.edu	37	18	21214078	21214078	+	Silent	SNP	G	G	A			TCGA-D6-A6EN-01A-11D-A31L-08	TCGA-D6-A6EN-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	971ca2bc-cd7b-4ce1-a471-81445b85e3a4	20f2c75b-d578-4332-83cb-0e2307d84fff	g.chr18:21214078G>A	ENST00000592179.1	-	5	520	c.366C>T	c.(364-366)taC>taT	p.Y122Y	ANKRD29_ENST00000322980.9_Silent_p.Y122Y|ANKRD29_ENST00000284207.7_Silent_p.Y122Y	NM_173505.2	NP_775776.2	Q8N6D5	ANR29_HUMAN	ankyrin repeat domain 29	122										breast(1)|kidney(1)|large_intestine(2)|lung(4)|ovary(3)|prostate(1)|skin(1)	13	all_cancers(21;5.07e-05)|all_epithelial(16;2.49e-07)|Lung NSC(20;0.00211)|all_lung(20;0.00676)|Colorectal(14;0.0202)|Ovarian(20;0.127)					GCATGTGCCCGTACTGACTGG	0.512000													15	46					0	0	1	0	0
RELB	5971	broad.mit.edu	37	19	45515201	45515201	+	Silent	SNP	C	C	T			TCGA-D6-A6EN-01A-11D-A31L-08	TCGA-D6-A6EN-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	971ca2bc-cd7b-4ce1-a471-81445b85e3a4	20f2c75b-d578-4332-83cb-0e2307d84fff	g.chr19:45515201C>T	ENST00000221452.8	+	4	321	c.171C>T	c.(169-171)atC>atT	p.I57I	RELB_ENST00000540120.1_Silent_p.I57I|RELB_ENST00000505236.1_Silent_p.I54I	NM_006509.3	NP_006500.2	Q01201	RELB_HUMAN	v-rel avian reticuloendotheliosis viral oncogene homolog B	57	Leucine-zipper.					nucleus	protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(3)|ovary(3)|skin(1)	12		Ovarian(192;0.0728)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.00986)		CAGAGATCATCGACGAGTACA	0.557000													3	15					0	0	1	0	0
SLC39A10	57181	broad.mit.edu	37	2	196545452	196545452	+	Missense_Mutation	SNP	C	C	T	rs139926734	by1000genomes	TCGA-D6-A6EN-01A-11D-A31L-08	TCGA-D6-A6EN-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	971ca2bc-cd7b-4ce1-a471-81445b85e3a4	20f2c75b-d578-4332-83cb-0e2307d84fff	g.chr2:196545452C>T	ENST00000409086.3	+	2	961	c.686C>T	c.(685-687)cCg>cTg	p.P229L	SLC39A10_ENST00000359634.5_Missense_Mutation_p.P229L|SLC39A10_ENST00000541054.1_Intron	NM_001127257.1	NP_001120729.1	Q9ULF5	S39AA_HUMAN	solute carrier family 39 (zinc transporter), member 10	229					zinc ion transport	integral to membrane	metal ion transmembrane transporter activity			breast(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(5)|liver(1)|lung(16)|pancreas(1)|prostate(1)|skin(2)	34			OV - Ovarian serous cystadenocarcinoma(117;0.221)			GTTAAACTACCGAAAGGAAAG	0.413000													9	35					0	0	1	0	0
FGD1	2245	broad.mit.edu	37	X	54475631	54475631	+	Missense_Mutation	SNP	T	T	A			TCGA-D6-A6EN-01A-11D-A31L-08	TCGA-D6-A6EN-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	971ca2bc-cd7b-4ce1-a471-81445b85e3a4	20f2c75b-d578-4332-83cb-0e2307d84fff	g.chrX:54475631T>A	ENST00000375135.3	-	15	2952	c.2219A>T	c.(2218-2220)cAg>cTg	p.Q740L		NM_004463.2	NP_004454.2	P98174	FGD1_HUMAN	FYVE, RhoGEF and PH domain containing 1	740					actin cytoskeleton organization|apoptosis|filopodium assembly|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|organ morphogenesis|regulation of Cdc42 GTPase activity|regulation of cell shape|small GTPase mediated signal transduction	cytoskeleton|cytosol|Golgi apparatus|lamellipodium|nucleus|plasma membrane|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(10)|lung(8)|ovary(3)|pancreas(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	39						GAAGGGCTCCTGGCAGCGCAT	0.602000													3	42					0	0	1	0	0
ATXN10	25814	broad.mit.edu	37	22	46125410	46125410	+	Silent	SNP	C	C	T			TCGA-D6-A6EN-01A-11D-A31L-08	TCGA-D6-A6EN-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	971ca2bc-cd7b-4ce1-a471-81445b85e3a4	20f2c75b-d578-4332-83cb-0e2307d84fff	g.chr22:46125410C>T	ENST00000252934.5	+	7	1099	c.834C>T	c.(832-834)acC>acT	p.T278T	ATXN10_ENST00000381061.4_Silent_p.T214T	NM_013236.3	NP_037368.1	Q9UBB4	ATX10_HUMAN	ataxin 10	278					cell death|neuron projection development	dendrite|neuronal cell body|perinuclear region of cytoplasm				central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(3)|ovary(1)|skin(1)	10		Ovarian(80;0.00973)|all_neural(38;0.0417)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0223)		TTGCAAGCACCTTTGTGGATC	0.488000													12	61					0	0	1	0	0
CEP250	11190	broad.mit.edu	37	20	34053609	34053609	+	Missense_Mutation	SNP	C	C	A			TCGA-D6-A6EN-01A-11D-A31L-08	TCGA-D6-A6EN-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	971ca2bc-cd7b-4ce1-a471-81445b85e3a4	20f2c75b-d578-4332-83cb-0e2307d84fff	g.chr20:34053609C>A	ENST00000397527.1	+	6	1005	c.285C>A	c.(283-285)aaC>aaA	p.N95K	CEP250_ENST00000397524.1_Missense_Mutation_p.N95K|CEP250_ENST00000342580.4_Missense_Mutation_p.N95K	NM_007186.3	NP_009117.2	Q9BV73	CP250_HUMAN	centrosomal protein 250kDa	95					centriole-centriole cohesion|G2/M transition of mitotic cell cycle|protein localization|regulation of centriole-centriole cohesion	centriole|cilium|cytosol|microtubule basal body|perinuclear region of cytoplasm|protein complex	protein C-terminus binding|protein kinase binding			NS(1)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(13)|lung(13)|ovary(4)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	45	Lung NSC(9;0.00156)|all_lung(11;0.00243)		BRCA - Breast invasive adenocarcinoma(18;0.0106)			AGGAGCCAAACCTGGATGAGC	0.542000													4	10					0.150653	0.1517	1	1	0
TNK2	10188	broad.mit.edu	37	3	195599248	195599248	+	Silent	SNP	C	C	T	rs112025939		TCGA-D6-A6EN-01A-11D-A31L-08	TCGA-D6-A6EN-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	971ca2bc-cd7b-4ce1-a471-81445b85e3a4	20f2c75b-d578-4332-83cb-0e2307d84fff	g.chr3:195599248C>T	ENST00000333602.6	-	10	1967	c.1350G>A	c.(1348-1350)tcG>tcA	p.S450S	TNK2_ENST00000392400.1_Silent_p.S450S|TNK2_ENST00000381916.2_Silent_p.S513S|TNK2_ENST00000316664.3_Silent_p.S450S|TNK2_ENST00000428187.1_Silent_p.S482S	NM_005781.4	NP_005772.3	Q07912	ACK1_HUMAN	tyrosine kinase, non-receptor, 2	450				Missing (in Ref. 4; AAH08884).	positive regulation of peptidyl-tyrosine phosphorylation|protein ubiquitination|small GTPase mediated signal transduction	adherens junction|cytoplasmic vesicle membrane|endosome|nucleus	ATP binding|GTPase inhibitor activity|metal ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding			central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(11)|ovary(3)|prostate(4)|skin(2)|stomach(1)|urinary_tract(1)	29	all_cancers(143;6.48e-09)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;1.46e-22)|OV - Ovarian serous cystadenocarcinoma(49;8.3e-19)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;0.000757)	Adenosine triphosphate(DB00171)	TGTCCTGGGCCGACAGGCCGG	0.672000													16	53					0	0	1	0	0
PCDHA11	56138	broad.mit.edu	37	5	140250635	140250635	+	Silent	SNP	G	G	A			TCGA-D6-A6EN-01A-11D-A31L-08	TCGA-D6-A6EN-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	971ca2bc-cd7b-4ce1-a471-81445b85e3a4	20f2c75b-d578-4332-83cb-0e2307d84fff	g.chr5:140250635G>A	ENST00000398640.2	+	1	1947	c.1947G>A	c.(1945-1947)ctG>ctA	p.L649L	PCDHA6_ENST00000527624.1_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA10_ENST00000506939.2_Intron|PCDHA10_ENST00000307360.5_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA8_ENST00000531613.1_Intron	NM_018902.3	NP_061725.1														breast(1)|lung(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TTCTAGTACTGGTGAAGGATC	0.667000													26	63					0	0	1	0	0
HSD17B7P2	158160	broad.mit.edu	37	10	38647361	38647361	+	RNA	SNP	C	C	T			TCGA-D6-A6EN-01A-11D-A31L-08	TCGA-D6-A6EN-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	971ca2bc-cd7b-4ce1-a471-81445b85e3a4	20f2c75b-d578-4332-83cb-0e2307d84fff	g.chr10:38647361C>T	ENST00000494540.1	+	0	232					NR_003086.1																						GGCCTCTCACCCCACTGCTGA	0.537000													7	24					0	0	1	0	0
IQCA1	79781	broad.mit.edu	37	2	237374200	237374200	+	Missense_Mutation	SNP	C	C	A			TCGA-D6-A6EN-01A-11D-A31L-08	TCGA-D6-A6EN-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	971ca2bc-cd7b-4ce1-a471-81445b85e3a4	20f2c75b-d578-4332-83cb-0e2307d84fff	g.chr2:237374200C>A	ENST00000409907.3	-	6	1148	c.874G>T	c.(874-876)Gat>Tat	p.D292Y	IQCA1_ENST00000431676.2_Missense_Mutation_p.D292Y|IQCA1_ENST00000309507.5_Missense_Mutation_p.D288Y			Q86XH1	IQCA1_HUMAN	IQ motif containing with AAA domain 1	292							ATP binding			cervix(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(12)|ovary(1)	26						TCCTTGATATCCACGCCTTCT	0.483000													3	25					0.00024832	0.000259039	1	1	0
DMXL2	23312	broad.mit.edu	37	15	51743860	51743860	+	Missense_Mutation	SNP	C	C	T			TCGA-D6-A6EN-01A-11D-A31L-08	TCGA-D6-A6EN-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	971ca2bc-cd7b-4ce1-a471-81445b85e3a4	20f2c75b-d578-4332-83cb-0e2307d84fff	g.chr15:51743860C>T	ENST00000251076.5	-	41	8952	c.8665G>A	c.(8665-8667)Gga>Aga	p.G2889R	DMXL2_ENST00000449909.3_Missense_Mutation_p.G2253R|DMXL2_ENST00000543779.2_Missense_Mutation_p.G2890R|RP11-707P17.1_ENST00000561007.1_RNA	NM_001174116.1|NM_015263.3	NP_001167587.1|NP_056078.2	Q8TDJ6	DMXL2_HUMAN	Dmx-like 2	2889						cell junction|synaptic vesicle membrane	Rab GTPase binding			breast(4)|central_nervous_system(1)|cervix(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(26)|liver(1)|lung(28)|ovary(7)|prostate(7)|skin(4)|stomach(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	101				all cancers(107;0.00494)		AGGCTGTTTCCGGGTGATATT	0.323000													7	19					0	0	1	0	0
GRM1	2911	broad.mit.edu	37	6	146480607	146480607	+	Missense_Mutation	SNP	G	G	A			TCGA-D6-A6EN-01A-11D-A31L-08	TCGA-D6-A6EN-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	971ca2bc-cd7b-4ce1-a471-81445b85e3a4	20f2c75b-d578-4332-83cb-0e2307d84fff	g.chr6:146480607G>A	ENST00000392299.2	+	3	1294	c.824G>A	c.(823-825)cGc>cAc	p.R275H	GRM1_ENST00000355289.4_Missense_Mutation_p.R275H|GRM1_ENST00000507907.1_Missense_Mutation_p.R275H|GRM1_ENST00000492807.2_Missense_Mutation_p.R275H|GRM1_ENST00000282753.1_Missense_Mutation_p.R275H|GRM1_ENST00000361719.2_Missense_Mutation_p.R275H			Q13255	GRM1_HUMAN	glutamate receptor, metabotropic 1	275					synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity	p.R275H(1)		NS(2)|breast(5)|central_nervous_system(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(54)|ovary(7)|pancreas(2)|prostate(5)|skin(7)|upper_aerodigestive_tract(4)|urinary_tract(1)	126		Ovarian(120;0.0387)		OV - Ovarian serous cystadenocarcinoma(155;5.35e-08)|GBM - Glioblastoma multiforme(68;0.00762)	Acamprosate(DB00659)|L-Glutamic Acid(DB00142)	CGACTCTTGCGCAAACTCCGA	0.577000													3	43					0	0	1	0	0
FRG1BP	284802	broad.mit.edu	37	20	29625877	29625877	+	Missense_Mutation	SNP	G	G	A	rs7266938	by1000genomes	TCGA-D6-A6EN-01A-11D-A31L-08	TCGA-D6-A6EN-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	971ca2bc-cd7b-4ce1-a471-81445b85e3a4	20f2c75b-d578-4332-83cb-0e2307d84fff	g.chr20:29625877G>A	ENST00000278882.3	+	5	501	c.121G>A	c.(121-123)Gcc>Acc	p.A41T	FRG1B_ENST00000439954.2_Missense_Mutation_p.A46T|FRG1B_ENST00000358464.4_Missense_Mutation_p.A41T														p.A41T(2)		endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						GTACAGAATCGCCCTGAAATC	0.358000													5	59					0	0	1	0	0
APOA1BP	128240	broad.mit.edu	37	1	156562233	156562233	+	Missense_Mutation	SNP	A	A	T			TCGA-D6-A6EN-01A-11D-A31L-08	TCGA-D6-A6EN-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	971ca2bc-cd7b-4ce1-a471-81445b85e3a4	20f2c75b-d578-4332-83cb-0e2307d84fff	g.chr1:156562233A>T	ENST00000368235.3	+	3	411	c.368A>T	c.(367-369)gAt>gTt	p.D123V	APOA1BP_ENST00000368234.3_Missense_Mutation_p.D123V|APOA1BP_ENST00000368233.3_Missense_Mutation_p.D123V|APOA1BP_ENST00000467374.1_3'UTR	NM_144772.2	NP_658985.2	Q8NCW5	AIBP_HUMAN	apolipoprotein A-I binding protein	123	YjeF N-terminal.					extracellular region	protein binding			central_nervous_system(1)|large_intestine(2)|lung(3)|prostate(2)|urinary_tract(1)	9	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					AATGGAGGAGATGGTCTGGTC	0.587000													19	76					0	0	1	0	0
AFM	173	broad.mit.edu	37	4	74357800	74357800	+	Missense_Mutation	SNP	C	C	G	rs151113361	byFrequency	TCGA-D6-A6EN-01A-11D-A31L-08	TCGA-D6-A6EN-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	971ca2bc-cd7b-4ce1-a471-81445b85e3a4	20f2c75b-d578-4332-83cb-0e2307d84fff	g.chr4:74357800C>G	ENST00000226355.3	+	8	1148	c.1055C>G	c.(1054-1056)gCg>gGg	p.A352G		NM_001133.2	NP_001124.1	P43652	AFAM_HUMAN	afamin	352	Albumin 2.				vitamin transport		vitamin E binding			breast(2)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(8)|lung(9)|ovary(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	32	Breast(15;0.00102)		Epithelial(6;5.69e-05)|OV - Ovarian serous cystadenocarcinoma(6;0.000324)|all cancers(17;0.000555)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			ACCTTCTTTGCGAAGTAATAT	0.343000													8	48					0	0	1	0	0
PEG3	5178	broad.mit.edu	37	19	57326722	57326722	+	Missense_Mutation	SNP	G	G	A			TCGA-D6-A6EN-01A-11D-A31L-08	TCGA-D6-A6EN-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	971ca2bc-cd7b-4ce1-a471-81445b85e3a4	20f2c75b-d578-4332-83cb-0e2307d84fff	g.chr19:57326722G>A	ENST00000326441.9	-	10	3451	c.3088C>T	c.(3088-3090)Cgg>Tgg	p.R1030W	PEG3_ENST00000423103.2_Missense_Mutation_p.R1030W|ZIM2_ENST00000593711.1_Intron|ZIM2_ENST00000221722.5_Intron|ZIM2_ENST00000601070.1_Intron|ZIM2_ENST00000599935.1_Intron|PEG3_ENST00000593695.1_Missense_Mutation_p.R904W|PEG3_ENST00000598410.1_Missense_Mutation_p.R906W|ZIM2_ENST00000391708.3_Intron	NM_006210.2	NP_006201.1	Q9GZU2	PEG3_HUMAN	paternally expressed 3	1030					apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|biliary_tract(4)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(27)|lung(84)|ovary(8)|pancreas(5)|prostate(6)|skin(8)|stomach(2)|upper_aerodigestive_tract(6)	170		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)		CATTTGTTCCGCGCTTGCTCT	0.468000													16	31					0	0	1	0	0
RPS6KA3	6197	broad.mit.edu	37	X	20190989	20190989	+	Splice_Site	SNP	G	G	A			TCGA-D6-A6EN-01A-11D-A31L-08	TCGA-D6-A6EN-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	971ca2bc-cd7b-4ce1-a471-81445b85e3a4	20f2c75b-d578-4332-83cb-0e2307d84fff	g.chrX:20190989G>A	ENST00000379565.3	-	15	1435	c.1227_splice	c.e15-1	p.Q410_splice	RPS6KA3_ENST00000379548.4_Intron|RPS6KA3_ENST00000544447.1_Splice_Site_p.Q382_splice|RPS6KA3_ENST00000540702.1_Intron	NM_004586.2	NP_004577.1	P51812	KS6A3_HUMAN	ribosomal protein S6 kinase, 90kDa, polypeptide 3	410				Missing (in Ref. 3; BAD92170).	axon guidance|central nervous system development|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|skeletal system development|stress-activated MAPK cascade|synaptic transmission|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|caspase inhibitor activity|magnesium ion binding|protein serine/threonine kinase activity			breast(4)|central_nervous_system(4)|endometrium(3)|kidney(2)|large_intestine(5)|liver(14)|lung(7)|ovary(1)|stomach(1)	41						CTGTGTAACTGCTACAAAAAA	0.353000													7	6					0	0	1	0	0
TBP	6908	broad.mit.edu	37	6	170871052	170871052	+	Silent	SNP	G	G	A	rs112083427		TCGA-D6-A6EN-01A-11D-A31L-08	TCGA-D6-A6EN-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	971ca2bc-cd7b-4ce1-a471-81445b85e3a4	20f2c75b-d578-4332-83cb-0e2307d84fff	g.chr6:170871052G>A	ENST00000392092.2	+	3	507	c.228G>A	c.(226-228)caG>caA	p.Q76Q	TBP_ENST00000230354.6_Silent_p.Q76Q|TBP_ENST00000540980.1_Silent_p.Q56Q	NM_003194.4	NP_003185.1	P20226	TBP_HUMAN	TATA box binding protein	76	Poly-Gln.				cell death|interspecies interaction between organisms|transcription elongation from RNA polymerase II promoter|transcription from RNA polymerase III promoter|viral reproduction	transcription factor TFIIA complex|transcription factor TFIID complex	repressing transcription factor binding|transcription regulatory region DNA binding	p.Q76Q(4)		breast(2)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(2)|lung(9)|ovary(1)|prostate(4)|urinary_tract(1)	26		Breast(66;5.08e-05)|Ovarian(120;0.125)|Esophageal squamous(34;0.246)		OV - Ovarian serous cystadenocarcinoma(33;1.07e-22)|BRCA - Breast invasive adenocarcinoma(81;5.01e-06)|GBM - Glioblastoma multiforme(31;0.00591)		agcaacagcagcagcagcagc	0.572000													5	58					0	0	1	0	0
RBMXL2	27288	broad.mit.edu	37	11	7111346	7111346	+	Missense_Mutation	SNP	G	G	A			TCGA-D6-A6EN-01A-11D-A31L-08	TCGA-D6-A6EN-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	971ca2bc-cd7b-4ce1-a471-81445b85e3a4	20f2c75b-d578-4332-83cb-0e2307d84fff	g.chr11:7111346G>A	ENST00000306904.5	+	1	1182	c.995G>A	c.(994-996)cGg>cAg	p.R332Q		NM_014469.4	NP_055284.3	O75526	HNRGT_HUMAN	RNA binding motif protein, X-linked-like 2	332	Arg/Gly/Pro-rich.					nucleus|ribonucleoprotein complex	nucleotide binding|RNA binding			NS(1)|breast(1)|endometrium(2)|large_intestine(2)|lung(6)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	15				Epithelial(150;5.14e-08)|BRCA - Breast invasive adenocarcinoma(625;0.189)		AGTTATGGCCGGAGCGACCGC	0.652000													6	33					0	0	1	0	0
PTPN14	5784	broad.mit.edu	37	1	214557391	214557391	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D6-A6EN-01A-11D-A31L-08	TCGA-D6-A6EN-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	971ca2bc-cd7b-4ce1-a471-81445b85e3a4	20f2c75b-d578-4332-83cb-0e2307d84fff	g.chr1:214557391G>A	ENST00000366956.5	-	13	2001	c.1807C>T	c.(1807-1809)Cag>Tag	p.Q603*	PTPN14_ENST00000543945.1_3'UTR	NM_005401.4	NP_005392.2	Q15678	PTN14_HUMAN	protein tyrosine phosphatase, non-receptor type 14	603					lymphangiogenesis	cytoplasm|cytoskeleton	protein tyrosine phosphatase activity|receptor tyrosine kinase binding			NS(2)|breast(3)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(9)|liver(3)|lung(21)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	58				OV - Ovarian serous cystadenocarcinoma(81;0.00181)|all cancers(67;0.00194)|Epithelial(68;0.0157)|GBM - Glioblastoma multiforme(131;0.155)		ACCGAGAGCTGCACCTTCCGG	0.662000													10	31					0	0	1	0	0
KLHL4	56062	broad.mit.edu	37	X	86880613	86880613	+	Missense_Mutation	SNP	C	C	A			TCGA-D6-A6EN-01A-11D-A31L-08	TCGA-D6-A6EN-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	971ca2bc-cd7b-4ce1-a471-81445b85e3a4	20f2c75b-d578-4332-83cb-0e2307d84fff	g.chrX:86880613C>A	ENST00000373119.4	+	6	1286	c.1141C>A	c.(1141-1143)Ctg>Atg	p.L381M	KLHL4_ENST00000373114.4_Missense_Mutation_p.L381M	NM_019117.4	NP_061990.2	Q9C0H6	KLHL4_HUMAN	kelch-like family member 4	381						cytoplasm|microtubule cytoskeleton|nucleolus	actin binding			NS(1)|biliary_tract(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(19)|lung(29)|ovary(2)|prostate(1)|skin(1)	67						TTTTCAGTTACTGGCAGATCT	0.408000													9	9					2.17888e-05	2.30611e-05	1	1	0
CLCA4	22802	broad.mit.edu	37	1	87040331	87040331	+	Missense_Mutation	SNP	C	C	G			TCGA-D6-A6EN-01A-11D-A31L-08	TCGA-D6-A6EN-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	971ca2bc-cd7b-4ce1-a471-81445b85e3a4	20f2c75b-d578-4332-83cb-0e2307d84fff	g.chr1:87040331C>G	ENST00000370563.3	+	10	1618	c.1576C>G	c.(1576-1578)Ctg>Gtg	p.L526V	RP4-651E10.4_ENST00000456587.1_RNA	NM_012128.3	NP_036260.2	Q14CN2	CLCA4_HUMAN	chloride channel accessory 4	526						apical plasma membrane|extracellular region|integral to plasma membrane	chloride channel activity			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(7)|liver(2)|lung(21)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	44		Lung NSC(277;0.238)		all cancers(265;0.0202)|Epithelial(280;0.0404)		ATGGAACAGTCTGCCTCCCAG	0.423000													13	49					0	0	1	0	0
AP2A2	161	broad.mit.edu	37	11	977193	977193	+	Missense_Mutation	SNP	G	G	A			TCGA-D6-A6EN-01A-11D-A31L-08	TCGA-D6-A6EN-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	971ca2bc-cd7b-4ce1-a471-81445b85e3a4	20f2c75b-d578-4332-83cb-0e2307d84fff	g.chr11:977193G>A	ENST00000448903.2	+	5	713	c.572G>A	c.(571-573)cGa>cAa	p.R191Q	AP2A2_ENST00000534328.1_Missense_Mutation_p.R191Q|AP2A2_ENST00000332231.5_Missense_Mutation_p.R191Q	NM_001242837.1|NM_012305.3	NP_001229766.1|NP_036437.1	O94973	AP2A2_HUMAN	adaptor-related protein complex 2, alpha 2 subunit	191					axon guidance|endocytosis|epidermal growth factor receptor signaling pathway|intracellular protein transport|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|regulation of defense response to virus by virus|synaptic transmission|viral reproduction	AP-2 adaptor complex|cytosol	lipid binding|protein transporter activity			breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(6)|ovary(2)	21		all_cancers(49;9.46e-06)|Breast(177;0.00257)|all_epithelial(84;0.0027)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;1.75e-24)|BRCA - Breast invasive adenocarcinoma(625;5.73e-05)|Lung(200;0.0696)|LUSC - Lung squamous cell carcinoma(625;0.082)		TGGACATCCCGAGTGGTGCAC	0.607000													6	22					0	0	1	0	0
MAP3K13	9175	broad.mit.edu	37	3	185190929	185190929	+	Missense_Mutation	SNP	G	G	A			TCGA-D6-A6EN-01A-11D-A31L-08	TCGA-D6-A6EN-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	971ca2bc-cd7b-4ce1-a471-81445b85e3a4	20f2c75b-d578-4332-83cb-0e2307d84fff	g.chr3:185190929G>A	ENST00000265026.3	+	11	2144	c.1810G>A	c.(1810-1812)Gca>Aca	p.A604T	MAP3K13_ENST00000446828.1_Missense_Mutation_p.A397T|MAP3K13_ENST00000443863.1_Missense_Mutation_p.A460T|MAP3K13_ENST00000424227.1_Missense_Mutation_p.A604T|MAP3K13_ENST00000535426.1_Missense_Mutation_p.A460T	NM_004721.4	NP_004712.1	O43283	M3K13_HUMAN	mitogen-activated protein kinase kinase kinase 13	604					activation of MAPKK activity|JNK cascade|positive regulation of NF-kappaB transcription factor activity|protein autophosphorylation	cytoplasm|membrane|membrane fraction	ATP binding|magnesium ion binding|MAP kinase kinase kinase activity|protein homodimerization activity|protein kinase binding			NS(1)|biliary_tract(1)|breast(3)|endometrium(3)|kidney(1)|large_intestine(13)|lung(22)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	54	all_cancers(143;7.21e-11)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;1.93e-20)			TGACTTTGCCGCAATCTTGAA	0.507000													5	388					0	0	1	0	0
FAT1	2195	broad.mit.edu	37	4	187521451	187521451	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D6-A6EN-01A-11D-A31L-08	TCGA-D6-A6EN-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	971ca2bc-cd7b-4ce1-a471-81445b85e3a4	20f2c75b-d578-4332-83cb-0e2307d84fff	g.chr4:187521451G>A	ENST00000441802.2	-	22	11913	c.11704C>T	c.(11704-11706)Cag>Tag	p.Q3902*		NM_005245.3	NP_005236.2	Q14517	FAT1_HUMAN	FAT atypical cadherin 1	3902	Laminin G-like.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(38)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(33)|lung(88)|ovary(13)|pancreas(2)|prostate(16)|skin(2)|upper_aerodigestive_tract(11)|urinary_tract(4)	228						TGAATGCTCTGAACAGAGACA	0.473000										HNSCC(5;0.00058)			5	11					0	0	1	0	0
SNX13	23161	broad.mit.edu	37	7	17833690	17833690	+	Silent	SNP	C	C	T			TCGA-D6-A6EN-01A-11D-A31L-08	TCGA-D6-A6EN-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	971ca2bc-cd7b-4ce1-a471-81445b85e3a4	20f2c75b-d578-4332-83cb-0e2307d84fff	g.chr7:17833690C>T	ENST00000428135.3	-	26	3051	c.2853G>A	c.(2851-2853)gcG>gcA	p.A951A	SNX13_ENST00000496855.1_5'UTR|SNX13_ENST00000409389.1_3'UTR	NM_015132.4	NP_055947.1	Q9Y5W8	SNX13_HUMAN	sorting nexin 13	962					cell communication|intracellular protein transport|negative regulation of signal transduction|positive regulation of GTPase activity	early endosome membrane	phosphatidylinositol binding|signal transducer activity			breast(1)|central_nervous_system(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(10)|lung(13)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	38	Lung NSC(10;0.0261)|all_lung(11;0.0521)					GCAAAGAAGGCGCTTGAGTAG	0.398000													6	16					0	0	1	0	0
CLOCK	9575	broad.mit.edu	37	4	56301652	56301652	+	Missense_Mutation	SNP	T	T	A			TCGA-D6-A6EN-01A-11D-A31L-08	TCGA-D6-A6EN-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	971ca2bc-cd7b-4ce1-a471-81445b85e3a4	20f2c75b-d578-4332-83cb-0e2307d84fff	g.chr4:56301652T>A	ENST00000309964.4	-	22	2721	c.2471A>T	c.(2470-2472)cAg>cTg	p.Q824L	CLOCK_ENST00000381322.1_Missense_Mutation_p.Q824L|CLOCK_ENST00000513440.1_Missense_Mutation_p.Q824L	NM_004898.3	NP_004889.1	O15516	CLOCK_HUMAN	clock circadian regulator	824	Poly-Gln.				circadian rhythm|photoperiodism|positive regulation of transcription from RNA polymerase II promoter	cytoplasm|transcription factor complex	DNA binding|histone acetyltransferase activity|sequence-specific DNA binding transcription factor activity|signal transducer activity			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(4)|kidney(5)|large_intestine(9)|lung(8)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	38	Lung NSC(11;0.00335)|Glioma(25;0.08)|all_epithelial(27;0.0992)|all_neural(26;0.101)		LUSC - Lung squamous cell carcinoma(4;1.62e-07)|Lung(4;1.34e-06)|Epithelial(7;0.0107)			CTGCTGTTGCTGAGACTGATG	0.527000													4	102					0	0	1	0	0
EPHA2	1969	broad.mit.edu	37	1	16475080	16475094	+	In_Frame_Del	DEL	GCAGCAGCTCGGGGC	GCAGCAGCTCGGGGC	-			TCGA-D6-A6EN-01A-11D-A31L-08	TCGA-D6-A6EN-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	971ca2bc-cd7b-4ce1-a471-81445b85e3a4	20f2c75b-d578-4332-83cb-0e2307d84fff	g.chr1:16475080_16475094delGCAGCAGCTCGGGGC	ENST00000358432.5	-	3	756_770	c.602_616delGCCCCGAGCTGCTGC	c.(601-618)tag>t	p.CPELLQ201del	EPHA2_ENST00000461614.1_5'UTR	NM_004431.3	NP_004422.2	P29317	EPHA2_HUMAN	EPH receptor A2	201	Cys-rich.				activation of Rac GTPase activity|angiogenesis|apoptosis|cell chemotaxis|negative regulation of protein kinase B signaling cascade|positive regulation of establishment of protein localization in plasma membrane|protein kinase B signaling cascade|regulation of blood vessel endothelial cell migration|regulation of cell adhesion mediated by integrin|regulation of lamellipodium assembly|response to growth factor stimulus	focal adhesion|integral to plasma membrane|lamellipodium membrane|ruffle membrane	ATP binding|ephrin receptor activity|protein binding			NS(1)|biliary_tract(1)|breast(3)|central_nervous_system(3)|cervix(2)|endometrium(1)|kidney(1)|large_intestine(6)|lung(12)|ovary(2)|pancreas(1)|prostate(3)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	42		Colorectal(325;3.46e-05)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0181)|Colorectal(212;3.63e-07)|COAD - Colon adenocarcinoma(227;2.25e-05)|BRCA - Breast invasive adenocarcinoma(304;9.58e-05)|Kidney(64;0.000175)|KIRC - Kidney renal clear cell carcinoma(64;0.00261)|STAD - Stomach adenocarcinoma(313;0.00669)|READ - Rectum adenocarcinoma(331;0.0649)	Dasatinib(DB01254)	GCCAGGCCCTGCAGCAGCTCGGGGCACTTCTTGTA	0.665													16	25	---	---	---	---					
NES	10763	broad.mit.edu	37	1	156639587	156639590	+	Frame_Shift_Del	DEL	CACT	CACT	-			TCGA-D6-A6EN-01A-11D-A31L-08	TCGA-D6-A6EN-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	971ca2bc-cd7b-4ce1-a471-81445b85e3a4	20f2c75b-d578-4332-83cb-0e2307d84fff	g.chr1:156639587_156639590delCACT	ENST00000368223.3	-	4	4522_4525	c.4390_4393delAGTG	c.(4390-4395)tcfs	p.SV1466fs		NM_006617.1	NP_006608.1	P48681	NEST_HUMAN	nestin	1466	Tail.				brain development|embryonic camera-type eye development|G2/M transition of mitotic cell cycle|negative regulation of apoptosis|positive regulation of intermediate filament depolymerization|positive regulation of neural precursor cell proliferation|stem cell proliferation	cytoplasm|intermediate filament	intermediate filament binding|structural molecule activity			central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(30)|ovary(6)|prostate(1)|skin(3)|stomach(1)|urinary_tract(4)	64	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					GGGACACTGACACTCACAGAATCA	0.637													11	52	---	---	---	---					
NIFK-AS1	254128	broad.mit.edu	37	2	122466739	122466740	+	RNA	INS	-	-	T	rs6733674	by1000genomes	TCGA-D6-A6EN-01A-11D-A31L-08	TCGA-D6-A6EN-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	971ca2bc-cd7b-4ce1-a471-81445b85e3a4	20f2c75b-d578-4332-83cb-0e2307d84fff	g.chr2:122466739_122466740insT	ENST00000419902.1	+	0	637					NR_037857.1																						tttttttgttgttttttttttg	0.460													3	5	---	---	---	---					
STAB1	23166	broad.mit.edu	37	3	52555493	52555494	+	Frame_Shift_Del	DEL	TG	TG	-			TCGA-D6-A6EN-01A-11D-A31L-08	TCGA-D6-A6EN-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	971ca2bc-cd7b-4ce1-a471-81445b85e3a4	20f2c75b-d578-4332-83cb-0e2307d84fff	g.chr3:52555493_52555494delTG	ENST00000321725.6	+	56	6101_6102	c.6025_6026delTG	c.(6025-6027)tfs	p.C2009fs		NM_015136.2	NP_055951.2	Q9NY15	STAB1_HUMAN	stabilin 1	2009	Laminin EGF-like 2.				cell adhesion|cell-cell signaling|defense response to bacterium|inflammatory response|negative regulation of angiogenesis|receptor-mediated endocytosis	integral to plasma membrane	bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			breast(4)|central_nervous_system(3)|endometrium(7)|kidney(2)|large_intestine(13)|liver(1)|lung(27)|ovary(1)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(3)	76				BRCA - Breast invasive adenocarcinoma(193;1.73e-05)|Kidney(197;0.00182)|KIRC - Kidney renal clear cell carcinoma(197;0.00205)|OV - Ovarian serous cystadenocarcinoma(275;0.0482)		CTGTGAACTCTGTGCTCCTGGT	0.604													22	59	---	---	---	---					
PODXL	5420	broad.mit.edu	37	7	131241030	131241035	+	In_Frame_Del	DEL	GGCGAC	GGCGAC	-	rs11277659		TCGA-D6-A6EN-01A-11D-A31L-08	TCGA-D6-A6EN-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	971ca2bc-cd7b-4ce1-a471-81445b85e3a4	20f2c75b-d578-4332-83cb-0e2307d84fff	g.chr7:131241030_131241035delGGCGAC	ENST00000541194.1	-	1	341_346	c.84_89delGTCGCC	c.(82-90)ccc>cc	p.PSP28del	PODXL_ENST00000537928.1_In_Frame_Del_p.PSP28del|PODXL_ENST00000465001.1_Intron|PODXL_ENST00000322985.9_In_Frame_Del_p.PSP28del|PODXL_ENST00000378555.3_In_Frame_Del_p.PSP28del	NM_001018111.2	NP_001018121.1	O00592	PODXL_HUMAN	podocalyxin-like	28					cell adhesion|epithelial tube formation|negative regulation of cell-cell adhesion|positive regulation of cell migration|positive regulation of cell-cell adhesion mediated by integrin|regulation of microvillus assembly	actin cytoskeleton|apical plasma membrane|centrosome|filopodium|integral to plasma membrane|lamellipodium|membrane raft|microvillus membrane|nucleolus|ruffle		p.P30_S31delPS(2)		NS(1)|breast(3)|endometrium(3)|kidney(3)|large_intestine(4)|lung(4)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	24	Melanoma(18;0.162)					ATTCTGGGAGggcgacggcgacggcg	0.748													2	4	---	---	---	---					
SSPO	23145	broad.mit.edu	37	7	149526874	149526874	+	RNA	DEL	C	C	-			TCGA-D6-A6EN-01A-11D-A31L-08	TCGA-D6-A6EN-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	971ca2bc-cd7b-4ce1-a471-81445b85e3a4	20f2c75b-d578-4332-83cb-0e2307d84fff	g.chr7:149526874delC	ENST00000378016.2	+	0	15142							A2VEC9	SSPO_HUMAN	SCO-spondin						cell adhesion	extracellular space	peptidase inhibitor activity					Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			cctcctgtgtcccccccacag	0.657													2	4	---	---	---	---					
CDKN2A	1029	broad.mit.edu	37	9	21971199	21971200	+	Frame_Shift_Ins	INS	-	-	AT	rs104894095		TCGA-D6-A6EN-01A-11D-A31L-08	TCGA-D6-A6EN-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	971ca2bc-cd7b-4ce1-a471-81445b85e3a4	20f2c75b-d578-4332-83cb-0e2307d84fff	g.chr9:21971199_21971200insAT	ENST00000579755.1	-	2	493_494	c.201_202insAT	c.(199-204)gaatggfs	p.W68fs	CDKN2A_ENST00000498628.2_Frame_Shift_Ins_p.N2fs|CDKN2A_ENST00000479692.2_Frame_Shift_Ins_p.N2fs|CDKN2A_ENST00000578845.2_Frame_Shift_Ins_p.N2fs|CDKN2A_ENST00000530628.2_Frame_Shift_Ins_p.W68fs|RP11-145E5.5_ENST00000404796.2_Intron|CDKN2A_ENST00000304494.5_Frame_Shift_Ins_p.N53fs|CDKN2A_ENST00000494262.1_Frame_Shift_Ins_p.N2fs|CDKN2A_ENST00000579122.1_Frame_Shift_Ins_p.N53fs|CDKN2A_ENST00000498124.1_Frame_Shift_Ins_p.N53fs|CDKN2A_ENST00000361570.3_Frame_Shift_Ins_p.W109fs|CDKN2A_ENST00000446177.1_Frame_Shift_Ins_p.N53fs|CDKN2A_ENST00000497750.1_Frame_Shift_Ins_p.N2fs			P42771	CD2A1_HUMAN	cyclin-dependent kinase inhibitor 2A	44			A -> L (in CMM2; requires 2 nucleotide substitutions).|A -> T (in an esophagus tumor).|A -> V.|Missing (in melanoma; loss of CDK4 binding).		cell cycle arrest|cell cycle checkpoint|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of cell-matrix adhesion|negative regulation of cyclin-dependent protein kinase activity|negative regulation of NF-kappaB transcription factor activity|positive regulation of macrophage apoptosis|positive regulation of smooth muscle cell apoptosis|Ras protein signal transduction|replicative senescence	cytosol|nucleus	cyclin-dependent protein kinase inhibitor activity|NF-kappaB binding|protein binding|protein kinase binding	p.0?(1315)|p.?(45)|p.M53_R58del(3)|p.M53I(2)|p.0(1)|p.V28_V51del(1)|p.D109H(1)|p.M53T(1)		NS(28)|adrenal_gland(6)|autonomic_ganglia(11)|biliary_tract(74)|bone(84)|breast(46)|central_nervous_system(522)|cervix(23)|endometrium(14)|eye(4)|genital_tract(15)|haematopoietic_and_lymphoid_tissue(698)|kidney(39)|large_intestine(11)|liver(92)|lung(365)|meninges(18)|oesophagus(239)|ovary(98)|pancreas(263)|pleura(94)|prostate(13)|salivary_gland(10)|skin(541)|small_intestine(1)|soft_tissue(93)|stomach(48)|thymus(4)|thyroid(24)|upper_aerodigestive_tract(436)|urinary_tract(283)|vulva(2)	4199		all_cancers(5;0)|Acute lymphoblastic leukemia(3;0)|all_hematologic(3;0)|all_epithelial(2;2.37e-290)|Lung NSC(2;1.26e-139)|all_lung(2;4.48e-131)|Glioma(2;3.26e-60)|all_neural(2;2.1e-52)|Renal(3;1.07e-46)|Esophageal squamous(3;3.83e-46)|Melanoma(2;2.74e-34)|Breast(3;1.14e-11)|Ovarian(3;0.000128)|Hepatocellular(5;0.00162)|Colorectal(97;0.172)		all cancers(2;0)|GBM - Glioblastoma multiforme(3;0)|Lung(2;4.07e-74)|Epithelial(2;1.08e-61)|LUSC - Lung squamous cell carcinoma(2;3.82e-48)|LUAD - Lung adenocarcinoma(2;4.56e-26)|OV - Ovarian serous cystadenocarcinoma(39;7.64e-10)|BRCA - Breast invasive adenocarcinoma(2;5.01e-09)|STAD - Stomach adenocarcinoma(4;4.63e-07)|Kidney(2;5.79e-07)|KIRC - Kidney renal clear cell carcinoma(2;7.27e-07)|COAD - Colon adenocarcinoma(8;5.15e-05)		CGCTGCCCATCATCATGACCTG	0.678		17								HNSCC(2;<9.43e_08)|TSP Lung(5;3.83e-07)			10	18	---	---	---	---					
BCL9L	283149	broad.mit.edu	37	11	118771661	118771662	+	Frame_Shift_Ins	INS	-	-	C			TCGA-D6-A6EN-01A-11D-A31L-08	TCGA-D6-A6EN-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	971ca2bc-cd7b-4ce1-a471-81445b85e3a4	20f2c75b-d578-4332-83cb-0e2307d84fff	g.chr11:118771661_118771662insC	ENST00000334801.3	-	6	3754_3755	c.2790_2791insG	c.(2788-2793)ggacttfs	p.L931fs	BCL9L_ENST00000526143.1_5'UTR	NM_182557.2	NP_872363.1	Q86UU0	BCL9L_HUMAN	B-cell CLL/lymphoma 9-like	931	Pro-rich.				negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of epithelial to mesenchymal transition|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		transcription coactivator activity			NS(3)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(13)|lung(20)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(2)	56	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0425)|all_hematologic(192;0.103)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.66e-05)		GACTTCAAGTGCCCCATGCCCG	0.619													36	47	---	---	---	---					
AJUBA	84962	broad.mit.edu	37	14	23447645	23447646	+	Frame_Shift_Ins	INS	-	-	T			TCGA-D6-A6EN-01A-11D-A31L-08	TCGA-D6-A6EN-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	971ca2bc-cd7b-4ce1-a471-81445b85e3a4	20f2c75b-d578-4332-83cb-0e2307d84fff	g.chr14:23447645_23447646insT	ENST00000262713.2	-	2	1390_1391	c.1015_1016insA	c.(1015-1017)caafs	p.Q339fs	AJUBA_ENST00000361265.4_Frame_Shift_Ins_p.Q339fs|RP11-298I3.5_ENST00000555074.1_Intron	NM_032876.4	NP_116265.1	Q96IF1	JUB_HUMAN	ajuba LIM protein	339	LIM zinc-binding 1.				cell cycle|gene silencing by miRNA|positive regulation of protein complex assembly	cell-cell junction|cytoplasmic mRNA processing body|microtubule organizing center	alpha-catenin binding|zinc ion binding										GTTGCACTTGATACAGGTGCCT	0.540													20	79	---	---	---	---					
ZNF594	84622	broad.mit.edu	37	17	5087404	5087404	+	Frame_Shift_Del	DEL	T	T	-			TCGA-D6-A6EN-01A-11D-A31L-08	TCGA-D6-A6EN-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	971ca2bc-cd7b-4ce1-a471-81445b85e3a4	20f2c75b-d578-4332-83cb-0e2307d84fff	g.chr17:5087404delT	ENST00000399604.4	-	1	288	c.148delA	c.(148-150)gcfs	p.S50fs	ZNF594_ENST00000575779.1_Frame_Shift_Del_p.S50fs			Q96JF6	ZN594_HUMAN	zinc finger protein 594	50					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(3)|lung(10)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	33						TTTAAAGGGCTTACCCAGTGC	0.458													26	52	---	---	---	---					
TBC1D3P2	440452	broad.mit.edu	37	17	60347260	60347260	+	RNA	DEL	T	T	-	rs71816198		TCGA-D6-A6EN-01A-11D-A31L-08	TCGA-D6-A6EN-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	971ca2bc-cd7b-4ce1-a471-81445b85e3a4	20f2c75b-d578-4332-83cb-0e2307d84fff	g.chr17:60347260delT	ENST00000581291.1	-	0	581																				breast(2)|kidney(1)|lung(2)	5						CTCTGAATGATTTTTTTTTTT	0.448													4	4	---	---	---	---					
KMT2B	9757	broad.mit.edu	37	19	36218439	36218440	+	Frame_Shift_Ins	INS	-	-	G			TCGA-D6-A6EN-01A-11D-A31L-08	TCGA-D6-A6EN-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	971ca2bc-cd7b-4ce1-a471-81445b85e3a4	20f2c75b-d578-4332-83cb-0e2307d84fff	g.chr19:36218439_36218440insG	ENST00000420124.1	+	16	4218_4219	c.4218_4219insG	c.(4216-4221)aggggcfs	p.RG1406fs	WBP7_ENST00000222270.7_Frame_Shift_Ins_p.RG1406fs|KMT2B_ENST00000607650.1_RNA																							AGGCCCTGAGCGGGGCCCTCCA	0.688													25	69	---	---	---	---					
HNRNPUL1	11100	broad.mit.edu	37	19	41770697	41770697	+	Frame_Shift_Del	DEL	G	G	-			TCGA-D6-A6EN-01A-11D-A31L-08	TCGA-D6-A6EN-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	971ca2bc-cd7b-4ce1-a471-81445b85e3a4	20f2c75b-d578-4332-83cb-0e2307d84fff	g.chr19:41770697delG	ENST00000392006.3	+	1	462	c.289delG	c.(289-291)gafs	p.G97fs	HNRNPUL1_ENST00000595018.1_Intron|HNRNPUL1_ENST00000378215.4_Frame_Shift_Del_p.G54fs|HNRNPUL1_ENST00000352456.3_Intron|HNRNPUL1_ENST00000602130.1_Frame_Shift_Del_p.G97fs	NM_007040.3	NP_008971.2	Q9BUJ2	HNRL1_HUMAN	heterogeneous nuclear ribonucleoprotein U-like 1	97	Necessary for interaction with HRMT1L1.				nuclear mRNA splicing, via spliceosome|regulation of transcription, DNA-dependent|response to virus|transcription, DNA-dependent	heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	enzyme binding|RNA binding			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(8)|prostate(1)|skin(1)|urinary_tract(1)	29						GGGGCCGGACGGACATTGTGA	0.776													2	4	---	---	---	---					
SNRNP70	6625	broad.mit.edu	37	19	49611236	49611236	+	Frame_Shift_Del	DEL	A	A	-			TCGA-D6-A6EN-01A-11D-A31L-08	TCGA-D6-A6EN-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	971ca2bc-cd7b-4ce1-a471-81445b85e3a4	20f2c75b-d578-4332-83cb-0e2307d84fff	g.chr19:49611236delA	ENST00000221448.5	+	10	1019	c.823delA	c.(823-825)agfs	p.K275fs	SNRNP70_ENST00000598441.1_Frame_Shift_Del_p.K284fs	NM_003089.4	NP_003080.2	P08621	RU17_HUMAN	small nuclear ribonucleoprotein 70kDa (U1)	284	Arg/Glu-rich (mixed charge).				nuclear mRNA splicing, via spliceosome|regulation of RNA splicing	nucleoplasm|spliceosomal complex	nucleotide binding|protein binding|RNA binding			cervix(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(3)|skin(2)	12						GAGCAAGGACAAGGACCGGGA	0.751													2	4	---	---	---	---