Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
CDC37L1	55664	broad.mit.edu	37	9	4697876	4697876	+	Silent	SNP	C	C	T			TCGA-F7-A622-01A-11D-A28R-08	TCGA-F7-A622-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1188c0e9-1f41-4b7e-8bfb-b6ad5a724466	46f9d879-7a87-4b25-adcb-bc10db818781	g.chr9:4697876C>T	ENST00000381854.3	+	5	946	c.744C>T	c.(742-744)gcC>gcT	p.A248A	CDC37L1_ENST00000381858.1_Silent_p.A248A	NM_017913.2	NP_060383.2	Q7L3B6	CD37L_HUMAN	cell division cycle 37-like 1	248	Self-association and interaction with Hsp90.					cytoplasm				breast(1)|kidney(1)|lung(2)	4	all_hematologic(13;0.137)	Breast(48;0.238)		GBM - Glioblastoma multiforme(50;0.0318)		TCCAGAAAGCCAAAGTAAGTA	0.373000													30	20					0	0	1	0	0
EP400	57634	broad.mit.edu	37	12	132446488	132446488	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A622-01A-11D-A28R-08	TCGA-F7-A622-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1188c0e9-1f41-4b7e-8bfb-b6ad5a724466	46f9d879-7a87-4b25-adcb-bc10db818781	g.chr12:132446488A>G	ENST00000333577.4	+	2	1433	c.1324A>G	c.(1324-1326)Atc>Gtc	p.I442V	EP400_ENST00000389561.2_Missense_Mutation_p.I442V|EP400_ENST00000389562.2_Missense_Mutation_p.I442V|EP400_ENST00000330386.6_Missense_Mutation_p.I442V|EP400_ENST00000332482.4_Missense_Mutation_p.I442V			Q96L91	EP400_HUMAN	E1A binding protein p400	442					histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nuclear speck	ATP binding|DNA binding|helicase activity			NS(1)|breast(6)|central_nervous_system(10)|cervix(1)|endometrium(21)|kidney(13)|large_intestine(25)|lung(56)|ovary(5)|prostate(8)|skin(6)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	161	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.198)		OV - Ovarian serous cystadenocarcinoma(86;3.01e-08)|Epithelial(86;3.43e-07)|all cancers(50;2.01e-06)		ATCTGAGGTTATCAATGACGA	0.368000													12	23					0	0	1	0	0
RIMS3	9783	broad.mit.edu	37	1	41107556	41107556	+	Silent	SNP	G	G	A			TCGA-F7-A622-01A-11D-A28R-08	TCGA-F7-A622-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1188c0e9-1f41-4b7e-8bfb-b6ad5a724466	46f9d879-7a87-4b25-adcb-bc10db818781	g.chr1:41107556G>A	ENST00000372684.3	-	3	511	c.42C>T	c.(40-42)tcC>tcT	p.S14S	RIMS3_ENST00000372683.1_Silent_p.S14S	NM_014747.2	NP_055562.2	Q9UJD0	RIMS3_HUMAN	regulating synaptic membrane exocytosis 3	14					neurotransmitter transport	cell junction|synapse				NS(2)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	23	Ovarian(52;0.00769)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;1.47e-17)			CCACATTCCTGGAGGCCCCAG	0.642000													12	35					0	0	1	0	0
MMP16	4325	broad.mit.edu	37	8	89128881	89128881	+	Missense_Mutation	SNP	G	G	T			TCGA-F7-A622-01A-11D-A28R-08	TCGA-F7-A622-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1188c0e9-1f41-4b7e-8bfb-b6ad5a724466	46f9d879-7a87-4b25-adcb-bc10db818781	g.chr8:89128881G>T	ENST00000286614.6	-	6	1219	c.938C>A	c.(937-939)cCt>cAt	p.P313H	MMP16_ENST00000544227.1_5'UTR	NM_005941.4	NP_005932.2	P51512	MMP16_HUMAN	matrix metallopeptidase 16 (membrane-inserted)	313					collagen catabolic process|proteolysis	cell surface|integral to plasma membrane|proteinaceous extracellular matrix	calcium ion binding|enzyme activator activity|metalloendopeptidase activity|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(5)|liver(1)|lung(51)|ovary(3)|prostate(4)|skin(1)|upper_aerodigestive_tract(5)|urinary_tract(3)	81						GTCAGCCGGAGGAATAGAGCG	0.547000													23	137					1.64293e-13	1.77984e-13	1	1	0
DDB1	1642	broad.mit.edu	37	11	61070124	61070124	+	Missense_Mutation	SNP	C	C	A			TCGA-F7-A622-01A-11D-A28R-08	TCGA-F7-A622-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1188c0e9-1f41-4b7e-8bfb-b6ad5a724466	46f9d879-7a87-4b25-adcb-bc10db818781	g.chr11:61070124C>A	ENST00000301764.7	-	24	3439	c.3042G>T	c.(3040-3042)atG>atT	p.M1014I	DDB1_ENST00000451943.2_Start_Codon_SNP_p.M1I|DDB1_ENST00000450997.2_Missense_Mutation_p.M325I|DDB1_ENST00000538470.1_Missense_Mutation_p.M61I	NM_001923.4	NP_001914.3	Q16531	DDB1_HUMAN	damage-specific DNA binding protein 1, 127kDa	1014	Interaction with CDT1 and CUL4A.				cell cycle checkpoint|interspecies interaction between organisms|nucleotide-excision repair, DNA damage removal|proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	Cul4A-RING ubiquitin ligase complex|Cul4B-RING ubiquitin ligase complex|cytoplasm|nucleoplasm	damaged DNA binding|protein binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(7)|lung(22)|ovary(2)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	48						CCAGATTCTGCATTACCAGAG	0.597000								Nucleotide excision repair (NER)					157	124					2.75688e-47	3.17564e-47	1	1	0
IGFN1	91156	broad.mit.edu	37	1	201195148	201195148	+	Silent	SNP	C	C	T			TCGA-F7-A622-01A-11D-A28R-08	TCGA-F7-A622-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1188c0e9-1f41-4b7e-8bfb-b6ad5a724466	46f9d879-7a87-4b25-adcb-bc10db818781	g.chr1:201195148C>T	ENST00000335211.4	+	22	10813	c.10683C>T	c.(10681-10683)atC>atT	p.I3561I	IGFN1_ENST00000295591.8_3'UTR	NM_001164586.1	NP_001158058.1			immunoglobulin-like and fibronectin type III domain containing 1											autonomic_ganglia(2)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(21)|ovary(2)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	45						TCCTGGGCATCCTCCCCGGCC	0.672000													26	54					0	0	1	0	0
PCDHB8	56128	broad.mit.edu	37	5	140558090	140558090	+	Nonsense_Mutation	SNP	G	G	T			TCGA-F7-A622-01A-11D-A28R-08	TCGA-F7-A622-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1188c0e9-1f41-4b7e-8bfb-b6ad5a724466	46f9d879-7a87-4b25-adcb-bc10db818781	g.chr5:140558090G>T	ENST00000239444.2	+	1	720	c.475G>T	c.(475-477)Gaa>Taa	p.E159*		NM_019120.3	NP_061993.2	Q9UN66	PCDB8_HUMAN		159	Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(2)|breast(1)|cervix(2)|endometrium(5)|kidney(6)|large_intestine(14)|liver(1)|lung(38)|prostate(6)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	83			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GAAGAATGCTGAAGACTTAGA	0.438000													24	469					7.92952e-12	8.48925e-12	1	1	0
ZSCAN5A	79149	broad.mit.edu	37	19	56733993	56733993	+	Missense_Mutation	SNP	T	T	A			TCGA-F7-A622-01A-11D-A28R-08	TCGA-F7-A622-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1188c0e9-1f41-4b7e-8bfb-b6ad5a724466	46f9d879-7a87-4b25-adcb-bc10db818781	g.chr19:56733993T>A	ENST00000587340.1	-	6	1401	c.706A>T	c.(706-708)Aca>Tca	p.T236S	ZSCAN5A_ENST00000254165.3_Missense_Mutation_p.T119S|ZSCAN5A_ENST00000391713.1_Missense_Mutation_p.T236S|ZSCAN5A_ENST00000587492.1_Missense_Mutation_p.T90S|ZSCAN5A_ENST00000592355.1_Missense_Mutation_p.T236S			Q9BUG6	ZSA5A_HUMAN	zinc finger and SCAN domain containing 5A	236					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(5)|liver(1)|lung(12)|ovary(1)|skin(6)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	37						TCTGGGGATGTCAGTCCTGGG	0.542000													19	54					0	0	1	0	0
VPS41	27072	broad.mit.edu	37	7	38869862	38869862	+	Missense_Mutation	SNP	C	C	G			TCGA-F7-A622-01A-11D-A28R-08	TCGA-F7-A622-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1188c0e9-1f41-4b7e-8bfb-b6ad5a724466	46f9d879-7a87-4b25-adcb-bc10db818781	g.chr7:38869862C>G	ENST00000310301.4	-	5	367	c.313G>C	c.(313-315)Gat>Cat	p.D105H	VPS41_ENST00000395969.2_Intron	NM_014396.3	NP_055211.2	P49754	VPS41_HUMAN	vacuolar protein sorting 41 homolog (S. cerevisiae)	105					Golgi vesicle transport|intracellular protein transport|vesicle-mediated transport	cytosol|Golgi-associated vesicle|HOPS complex|membrane fraction	zinc ion binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(5)|kidney(4)|large_intestine(5)|lung(17)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(4)	44						ACCTTGCCATCCTCTGAACAC	0.433000													6	700					0	0	1	0	0
RAB3D	9545	broad.mit.edu	37	19	11446172	11446172	+	Silent	SNP	G	G	A	rs139194537	byFrequency	TCGA-F7-A622-01A-11D-A28R-08	TCGA-F7-A622-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1188c0e9-1f41-4b7e-8bfb-b6ad5a724466	46f9d879-7a87-4b25-adcb-bc10db818781	g.chr19:11446172G>A	ENST00000222120.3	-	4	683	c.423C>T	c.(421-423)gaC>gaT	p.D141D	RAB3D_ENST00000589655.1_Silent_p.D141D	NM_004283.3	NP_004274.1	O95716	RAB3D_HUMAN	RAB3D, member RAS oncogene family	141					exocytosis|protein transport|small GTPase mediated signal transduction	plasma membrane	GTP binding|GTPase activity			cervix(1)|endometrium(3)|kidney(1)|large_intestine(3)|liver(1)|lung(3)|ovary(2)	14						CAACACGTTCGTCCTCCAGGT	0.617000													18	29					0	0	1	0	0
MCC	4163	broad.mit.edu	37	5	112824054	112824054	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A622-01A-11D-A28R-08	TCGA-F7-A622-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1188c0e9-1f41-4b7e-8bfb-b6ad5a724466	46f9d879-7a87-4b25-adcb-bc10db818781	g.chr5:112824054C>T	ENST00000408903.3	-	1	473	c.58G>A	c.(58-60)Ggc>Agc	p.G20S		NM_001085377.1	NP_001078846.1	P23508	CRCM_HUMAN	mutated in colorectal cancers	548					negative regulation of canonical Wnt receptor signaling pathway|negative regulation of epithelial cell migration|negative regulation of epithelial cell proliferation|Wnt receptor signaling pathway	cytoplasm|nucleus|plasma membrane	protein binding|receptor activity	p.G20S(1)		endometrium(4)|kidney(3)|large_intestine(15)|liver(2)|lung(8)|ovary(2)|pancreas(1)|prostate(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	42		all_cancers(142;5.89e-08)|all_epithelial(76;3.57e-11)|all_lung(232;0.000605)|Lung NSC(810;0.000697)|Colorectal(10;0.00146)|Prostate(80;0.00174)|Ovarian(225;0.0175)|Breast(839;0.198)		OV - Ovarian serous cystadenocarcinoma(64;2.04e-54)|Epithelial(69;9.69e-49)|all cancers(49;6.25e-44)|COAD - Colon adenocarcinoma(37;0.0432)|Colorectal(14;0.0766)		ccgctgccgccgccgccgccg	0.756000													4	1					0	0	1	0	0
DNAH17	8632	broad.mit.edu	37	17	76476820	76476820	+	Silent	SNP	G	G	A			TCGA-F7-A622-01A-11D-A28R-08	TCGA-F7-A622-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1188c0e9-1f41-4b7e-8bfb-b6ad5a724466	46f9d879-7a87-4b25-adcb-bc10db818781	g.chr17:76476820G>A	ENST00000389840.5	-	49	7780	c.7656C>T	c.(7654-7656)taC>taT	p.Y2552Y	DNAH17_ENST00000585328.1_Silent_p.Y2561Y|DNAH17_ENST00000586052.1_Intron					dynein, axonemal, heavy chain 17											NS(2)|breast(7)|central_nervous_system(5)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(13)|large_intestine(8)|lung(37)|ovary(8)|prostate(7)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	116			BRCA - Breast invasive adenocarcinoma(99;0.00294)|OV - Ovarian serous cystadenocarcinoma(97;0.0656)			TGCAGGCCACGTACTGACAAT	0.517000													7	25					0	0	1	0	0
FANCF	2188	broad.mit.edu	37	11	22647101	22647101	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A622-01A-11D-A28R-08	TCGA-F7-A622-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1188c0e9-1f41-4b7e-8bfb-b6ad5a724466	46f9d879-7a87-4b25-adcb-bc10db818781	g.chr11:22647101G>A	ENST00000327470.3	-	1	286	c.256C>T	c.(256-258)Ctc>Ttc	p.L86F	AC103801.2_ENST00000428556.2_Silent_p.E15E	NM_022725.3	NP_073562.1	Q9NPI8	FANCF_HUMAN	Fanconi anemia, complementation group F	86					DNA repair	nucleoplasm	protein binding			kidney(3)|large_intestine(3)|lung(6)|skin(1)	13						CAGTGACCGAGGGCCTGGAAG	0.662000			"""N, F"""			"""AML, leukemia"""		Involved in tolerance or repair of DNA crosslinks	Fanconi Anemia				65	134					0	0	1	0	0
NDUFB1	4707	broad.mit.edu	37	14	92583984	92583984	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A622-01A-11D-A28R-08	TCGA-F7-A622-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1188c0e9-1f41-4b7e-8bfb-b6ad5a724466	46f9d879-7a87-4b25-adcb-bc10db818781	g.chr14:92583984T>C	ENST00000329559.3	-	2	278	c.139A>G	c.(139-141)Atc>Gtc	p.I47V	NDUFB1_ENST00000605997.1_5'UTR|NDUFB1_ENST00000555441.1_5'UTR|NDUFB1_ENST00000553514.1_5'UTR	NM_004545.3	NP_004536.2	O75438	NDUB1_HUMAN	NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 1, 7kDa	0					mitochondrial electron transport, NADH to ubiquinone|transport	integral to membrane|mitochondrial respiratory chain complex I	NADH dehydrogenase (ubiquinone) activity			large_intestine(1)|lung(1)	2		all_cancers(154;0.0766)		COAD - Colon adenocarcinoma(157;0.205)	NADH(DB00157)	TTCACCATGATAGCTAAAAGA	0.378000													16	27					0	0	1	0	0
KSR2	283455	broad.mit.edu	37	12	117962852	117962852	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A622-01A-11D-A28R-08	TCGA-F7-A622-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1188c0e9-1f41-4b7e-8bfb-b6ad5a724466	46f9d879-7a87-4b25-adcb-bc10db818781	g.chr12:117962852C>T	ENST00000425217.1	-	14	1991	c.1937G>A	c.(1936-1938)gGc>gAc	p.G646D	KSR2_ENST00000545002.1_5'UTR|KSR2_ENST00000302438.5_Missense_Mutation_p.G372D|KSR2_ENST00000339824.5_Missense_Mutation_p.G675D	NM_173598.4	NP_775869.3	Q6VAB6	KSR2_HUMAN	kinase suppressor of ras 2	675					intracellular signal transduction	cytoplasm|membrane	ATP binding|metal ion binding|protein serine/threonine kinase activity			NS(1)|breast(3)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(25)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	67	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					CCCAAAGCGGCCCTTTCCAAT	0.612000													21	42					0	0	1	0	0
CES4A	283848	broad.mit.edu	37	16	67039294	67039294	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A622-01A-11D-A28R-08	TCGA-F7-A622-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1188c0e9-1f41-4b7e-8bfb-b6ad5a724466	46f9d879-7a87-4b25-adcb-bc10db818781	g.chr16:67039294G>A	ENST00000540947.2	+	11	1497	c.1313G>A	c.(1312-1314)cGa>cAa	p.R438Q	CES4A_ENST00000398354.1_Missense_Mutation_p.R411Q|CES4A_ENST00000326686.5_Missense_Mutation_p.R438Q|CES4A_ENST00000541479.1_Missense_Mutation_p.R434Q|CES4A_ENST00000338718.4_Missense_Mutation_p.R461Q|CES4A_ENST00000540579.1_Missense_Mutation_p.R340Q|CES4A_ENST00000535696.1_Missense_Mutation_p.R344Q	NM_173815.6	NP_776176.5	Q5XG92	EST4A_HUMAN	carboxylesterase 4A	438						extracellular region	carboxylesterase activity			large_intestine(2)|liver(2)|lung(4)|ovary(1)	9						CACTACCACCGAGGTATGCAG	0.542000													27	53					0	0	1	0	0
CFAP54	144535	broad.mit.edu	37	12	97078470	97078470	+	Silent	SNP	T	T	C			TCGA-F7-A622-01A-11D-A28R-08	TCGA-F7-A622-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1188c0e9-1f41-4b7e-8bfb-b6ad5a724466	46f9d879-7a87-4b25-adcb-bc10db818781	g.chr12:97078470T>C	ENST00000524981.3	+	8	1114	c.1114T>C	c.(1114-1116)Ttg>Ctg	p.L372L				Q6ZTY8	CL063_HUMAN		346										breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(26)|ovary(1)|prostate(2)|skin(11)|stomach(2)	54						AGTTCAGGCGTTGCATTCACT	0.323000													34	41					0	0	1	0	0
PDGFRB	5159	broad.mit.edu	37	5	149506164	149506164	+	Silent	SNP	C	C	T			TCGA-F7-A622-01A-11D-A28R-08	TCGA-F7-A622-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1188c0e9-1f41-4b7e-8bfb-b6ad5a724466	46f9d879-7a87-4b25-adcb-bc10db818781	g.chr5:149506164C>T	ENST00000261799.4	-	11	2062	c.1593G>A	c.(1591-1593)aaG>aaA	p.K531K		NM_002609.3	NP_002600.1	P09619	PGFRB_HUMAN	platelet-derived growth factor receptor, beta polypeptide	531					aorta morphogenesis|cardiac myofibril assembly|hemopoiesis|metanephric glomerular capillary formation|metanephric glomerular mesangial cell proliferation involved in metanephros development|peptidyl-tyrosine phosphorylation|positive regulation of calcium ion import|positive regulation of chemotaxis|positive regulation of DNA biosynthetic process|positive regulation of ERK1 and ERK2 cascade|positive regulation of MAP kinase activity|positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway|positive regulation of mitosis|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of reactive oxygen species metabolic process|positive regulation of smooth muscle cell migration|positive regulation of smooth muscle cell proliferation|protein autophosphorylation|regulation of actin cytoskeleton organization|retina vasculature development in camera-type eye|smooth muscle cell chemotaxis	apical plasma membrane|cytoplasm|integral to plasma membrane|nucleus	ATP binding|platelet activating factor receptor activity|platelet-derived growth factor beta-receptor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|vascular endothelial growth factor receptor activity			breast(3)|central_nervous_system(5)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(9)|kidney(3)|large_intestine(12)|lung(20)|ovary(3)|prostate(3)|skin(3)|stomach(6)|urinary_tract(1)	75		all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)		Becaplermin(DB00102)|Dasatinib(DB01254)|Imatinib(DB00619)|Sorafenib(DB00398)|Sunitinib(DB01268)	TCACCACCACCTTAAAGGGCA	0.572000			T	"""ETV6, TRIP11, HIP1, RAB5EP, H4, NIN, HCMOGT-1, PDE4DIP"""	"""MPD, AML, CMML, CML"""								26	17					0	0	1	0	0
MSH6	2956	broad.mit.edu	37	2	48026064	48026064	+	Missense_Mutation	SNP	C	C	G	rs150440246	byFrequency	TCGA-F7-A622-01A-11D-A28R-08	TCGA-F7-A622-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1188c0e9-1f41-4b7e-8bfb-b6ad5a724466	46f9d879-7a87-4b25-adcb-bc10db818781	g.chr2:48026064C>G	ENST00000234420.4	+	4	1094	c.942C>G	c.(940-942)agC>agG	p.S314R	MSH6_ENST00000538136.1_Missense_Mutation_p.S12R|FBXO11_ENST00000405808.1_Intron|MSH6_ENST00000540021.1_Missense_Mutation_p.S184R	NM_000179.2	NP_000170.1	P52701	MSH6_HUMAN	mutS homolog 6	314					determination of adult lifespan|DNA damage response, signal transduction resulting in induction of apoptosis|isotype switching|meiotic mismatch repair|negative regulation of DNA recombination|positive regulation of helicase activity|reciprocal meiotic recombination|response to UV|somatic hypermutation of immunoglobulin genes	MutSalpha complex	ATP binding|DNA-dependent ATPase activity|protein binding	p.0?(2)		breast(8)|central_nervous_system(29)|cervix(1)|endometrium(32)|haematopoietic_and_lymphoid_tissue(12)|kidney(2)|large_intestine(75)|lung(25)|ovary(3)|prostate(3)|skin(10)|stomach(22)|thyroid(1)|upper_aerodigestive_tract(1)|urinary_tract(5)	229		Acute lymphoblastic leukemia(82;0.0299)|all_hematologic(82;0.0358)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)			AAAGGAAAAGCTCTAGGAAGG	0.463000			"""Mis, N, F, S"""		colorectal	"""colorectal, endometrial, ovarian"""		Mismatch excision repair (MMR)	Turcot syndrome;Muir-Torre syndrome;Lynch syndrome;Constitutional Mismatch Repair Deficiency Syndrome				85	223					0	0	1	0	0
NOTCH1	4851	broad.mit.edu	37	9	139413085	139413085	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A622-01A-11D-A28R-08	TCGA-F7-A622-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1188c0e9-1f41-4b7e-8bfb-b6ad5a724466	46f9d879-7a87-4b25-adcb-bc10db818781	g.chr9:139413085G>A	ENST00000277541.6	-	6	1132	c.1057C>T	c.(1057-1059)Cgt>Tgt	p.R353C		NM_017617.3	NP_060087.3	P46531	NOTC1_HUMAN	notch 1	353	EGF-like 9; calcium-binding (Potential).				aortic valve morphogenesis|immune response|negative regulation of BMP signaling pathway|negative regulation of cell-substrate adhesion|negative regulation of myoblast differentiation|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-dependent|Notch receptor processing	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity	p.R353C(2)		breast(16)|central_nervous_system(17)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1183)|kidney(4)|large_intestine(1)|lung(57)|oesophagus(2)|ovary(3)|pancreas(1)|prostate(3)|skin(21)|upper_aerodigestive_tract(39)|urinary_tract(3)	1359	all_cancers(76;0.223)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.34e-06)|Epithelial(140;7.77e-06)		GAGGCCACACGGTCATGGCAG	0.652000			"""T, Mis, O"""	TRB@	T-ALL					HNSCC(8;0.001)			9	35					0	0	1	0	0
LINC00969	440993	broad.mit.edu	37	3	195410689	195410689	+	RNA	SNP	C	C	T	rs6583275	by1000genomes	TCGA-F7-A622-01A-11D-A28R-08	TCGA-F7-A622-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1188c0e9-1f41-4b7e-8bfb-b6ad5a724466	46f9d879-7a87-4b25-adcb-bc10db818781	g.chr3:195410689C>T	ENST00000445430.1	+	0	1886																											CTTTGAGGTGCACTGGAGGAA	0.567000													7	32					0	0	1	0	0
NOX5	79400	broad.mit.edu	37	15	69348934	69348934	+	Missense_Mutation	SNP	G	G	C			TCGA-F7-A622-01A-11D-A28R-08	TCGA-F7-A622-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1188c0e9-1f41-4b7e-8bfb-b6ad5a724466	46f9d879-7a87-4b25-adcb-bc10db818781	g.chr15:69348934G>C	ENST00000260364.5	+	17	2443	c.2142G>C	c.(2140-2142)aaG>aaC	p.K714N	NOX5_ENST00000388866.3_Missense_Mutation_p.K732N|NOX5_ENST00000448182.3_Missense_Mutation_p.K686N|NOX5_ENST00000530406.2_Missense_Mutation_p.K704N|NOX5_ENST00000455873.3_Missense_Mutation_p.K697N			Q96PH1	NOX5_HUMAN	NADPH oxidase, EF-hand calcium binding domain 5	732					angiogenesis|cytokine secretion|cytokinesis|electron transport chain|endothelial cell proliferation|induction of apoptosis|positive regulation of reactive oxygen species metabolic process|regulation of fusion of sperm to egg plasma membrane|regulation of proton transport|superoxide anion generation	endoplasmic reticulum|integral to membrane	calcium ion binding|electron carrier activity|flavin adenine dinucleotide binding|heme binding|hydrogen ion channel activity|NADP binding|superoxide-generating NADPH oxidase activity			breast(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|liver(2)|lung(18)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	35						CTGAGAAGAAGGGCAAGGTGC	0.527000													41	53					0	0	1	0	0
FOXR1	283150	broad.mit.edu	37	11	118851366	118851366	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A622-01A-11D-A28R-08	TCGA-F7-A622-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1188c0e9-1f41-4b7e-8bfb-b6ad5a724466	46f9d879-7a87-4b25-adcb-bc10db818781	g.chr11:118851366C>T	ENST00000317011.3	+	5	1003	c.778C>T	c.(778-780)Cgc>Tgc	p.R260C		NM_181721.2	NP_859072.1	Q6PIV2	FOXR1_HUMAN	forkhead box R1	260					embryo development|organ development|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(6)|prostate(1)|skin(1)	16	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0425)|all_hematologic(192;0.103)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.62e-05)		GGGACACCGCCGCTTTGCGGA	0.602000													39	102					0	0	1	0	0
DNAJB11	51726	broad.mit.edu	37	3	186289886	186289886	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A622-01A-11D-A28R-08	TCGA-F7-A622-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1188c0e9-1f41-4b7e-8bfb-b6ad5a724466	46f9d879-7a87-4b25-adcb-bc10db818781	g.chr3:186289886G>A	ENST00000439351.1	+	3	1000	c.71G>A	c.(70-72)cGa>cAa	p.R24Q	DNAJB11_ENST00000265028.3_Missense_Mutation_p.R24Q			Q9UBS4	DJB11_HUMAN	DnaJ (Hsp40) homolog, subfamily B, member 11	24					protein folding	endoplasmic reticulum lumen	heat shock protein binding			breast(1)|central_nervous_system(1)|kidney(2)|large_intestine(2)|lung(5)|ovary(1)|prostate(1)|urinary_tract(2)	15	all_cancers(143;2.84e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;1.44e-20)	GBM - Glioblastoma multiforme(93;0.0476)		CTTCCCAGACGAGATTTCTAT	0.388000													5	95					0	0	1	0	0
ADHFE1	137872	broad.mit.edu	37	8	67361106	67361106	+	Missense_Mutation	SNP	C	C	G	rs61743396		TCGA-F7-A622-01A-11D-A28R-08	TCGA-F7-A622-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1188c0e9-1f41-4b7e-8bfb-b6ad5a724466	46f9d879-7a87-4b25-adcb-bc10db818781	g.chr8:67361106C>G	ENST00000396623.3	+	8	666	c.635C>G	c.(634-636)aCt>aGt	p.T212S	ADHFE1_ENST00000415254.1_Missense_Mutation_p.T164S|ADHFE1_ENST00000379385.4_Missense_Mutation_p.T212S|ADHFE1_ENST00000496501.1_3'UTR	NM_144650.2	NP_653251.2	Q8IWW8	HOT_HUMAN	alcohol dehydrogenase, iron containing, 1	212					2-oxoglutarate metabolic process|molecular hydrogen transport	mitochondrial matrix	hydroxyacid-oxoacid transhydrogenase activity|metal ion binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(8)|lung(10)|ovary(1)|pancreas(1)|skin(2)|urinary_tract(2)	29		Lung NSC(129;0.197)	Epithelial(68;0.0321)|all cancers(69;0.0751)|BRCA - Breast invasive adenocarcinoma(89;0.0855)|OV - Ovarian serous cystadenocarcinoma(28;0.226)			TTAGGCATCACTTCGAGAGCC	0.443000													46	176					0	0	1	0	0
ABCA9	10350	broad.mit.edu	37	17	67031890	67031890	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A622-01A-11D-A28R-08	TCGA-F7-A622-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1188c0e9-1f41-4b7e-8bfb-b6ad5a724466	46f9d879-7a87-4b25-adcb-bc10db818781	g.chr17:67031890T>C	ENST00000340001.4	-	7	1064	c.853A>G	c.(853-855)Atg>Gtg	p.M285V	ABCA9_ENST00000370732.2_Missense_Mutation_p.M285V|ABCA9_ENST00000453985.2_Missense_Mutation_p.M285V	NM_080283.3	NP_525022.2	Q8IUA7	ABCA9_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 9	285					transport	integral to membrane	ATP binding|ATPase activity			NS(2)|breast(4)|central_nervous_system(3)|endometrium(8)|kidney(3)|large_intestine(21)|lung(35)|ovary(4)|prostate(5)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	91	Breast(10;1.47e-12)					ATAAGAGCCATTAAAGTGGCC	0.433000													16	29					0	0	1	0	0
FAT3	120114	broad.mit.edu	37	11	92533084	92533084	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A622-01A-11D-A28R-08	TCGA-F7-A622-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1188c0e9-1f41-4b7e-8bfb-b6ad5a724466	46f9d879-7a87-4b25-adcb-bc10db818781	g.chr11:92533084T>C	ENST00000298047.6	+	9	6922	c.6905T>C	c.(6904-6906)aTt>aCt	p.I2302T	FAT3_ENST00000409404.2_Missense_Mutation_p.I2302T|FAT3_ENST00000525166.1_Missense_Mutation_p.I2152T			Q8TDW7	FAT3_HUMAN	FAT atypical cadherin 3	2302	Cadherin 21.				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(10)|kidney(4)|large_intestine(11)|liver(2)|lung(37)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	85		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				GCATCTCTTATTGGGACACCT	0.378000										TCGA Ovarian(4;0.039)			15	20					0	0	1	0	0
LINC00969	440993	broad.mit.edu	37	3	195410687	195410687	+	RNA	SNP	T	T	A	rs6583274	by1000genomes	TCGA-F7-A622-01A-11D-A28R-08	TCGA-F7-A622-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1188c0e9-1f41-4b7e-8bfb-b6ad5a724466	46f9d879-7a87-4b25-adcb-bc10db818781	g.chr3:195410687T>A	ENST00000445430.1	+	0	1884																											CCCTTTGAGGTGCACTGGAGG	0.567000													7	30					0	0	1	0	0
RHO	6010	broad.mit.edu	37	3	129251468	129251468	+	Silent	SNP	C	C	T	rs121918590		TCGA-F7-A622-01A-11D-A28R-08	TCGA-F7-A622-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1188c0e9-1f41-4b7e-8bfb-b6ad5a724466	46f9d879-7a87-4b25-adcb-bc10db818781	g.chr3:129251468C>T	ENST00000296271.3	+	4	883	c.789C>T	c.(787-789)atC>atT	p.I263I		NM_000539.3	NP_000530.1	P08100	OPSD_HUMAN	rhodopsin	263					protein-chromophore linkage|rhodopsin mediated signaling pathway	Golgi apparatus|integral to plasma membrane|photoreceptor inner segment membrane|photoreceptor outer segment membrane	G-protein coupled receptor activity|metal ion binding|photoreceptor activity|protein binding			breast(1)|endometrium(1)|large_intestine(10)|lung(6)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	22		all_neural(597;0.0227)|Myeloproliferative disorder(1037;0.0255)|Prostate(884;0.183)		GBM - Glioblastoma multiforme(114;2.58e-05)|Lung(219;0.0234)	Halothane(DB01159)	CTTTCCTGATCTGCTGGGTGC	0.582000													30	35					0	0	1	0	0
FEM1A	55527	broad.mit.edu	37	19	4793061	4793061	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A622-01A-11D-A28R-08	TCGA-F7-A622-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1188c0e9-1f41-4b7e-8bfb-b6ad5a724466	46f9d879-7a87-4b25-adcb-bc10db818781	g.chr19:4793061G>A	ENST00000269856.3	+	1	1334	c.1195G>A	c.(1195-1197)Gtg>Atg	p.V399M	AC005523.2_ENST00000601192.1_RNA	NM_018708.2	NP_061178.1	Q9BSK4	FEM1A_HUMAN	fem-1 homolog a (C. elegans)	399					regulation of ubiquitin-protein ligase activity	cytoplasm	binding|ubiquitin-protein ligase activity			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(2)|lung(5)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	17		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0139)		CAGGGGTGCCGTGTACGCCGA	0.622000													32	99					0	0	1	0	0
CCDC7	221016	broad.mit.edu	37	10	32760080	32760080	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A622-01A-11D-A28R-08	TCGA-F7-A622-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1188c0e9-1f41-4b7e-8bfb-b6ad5a724466	46f9d879-7a87-4b25-adcb-bc10db818781	g.chr10:32760080T>C	ENST00000362006.5	+	7	1142	c.599T>C	c.(598-600)gTa>gCa	p.V200A	CCDC7_ENST00000537047.1_Intron|CCDC7_ENST00000539197.1_Intron|CCDC7_ENST00000545067.1_Intron|CCDC7_ENST00000535327.1_Intron|CCDC7_ENST00000277657.6_Missense_Mutation_p.V200A	NM_145023.4	NP_659460.3	Q96M83	CCDC7_HUMAN	coiled-coil domain containing 7	200										NS(1)|breast(2)|cervix(1)|endometrium(1)|large_intestine(3)|lung(4)|prostate(2)	14		Breast(68;0.000207)|Prostate(175;0.0107)				GTAAGGCTTGTACAAAGATTT	0.313000													8	17					0	0	1	0	0
ABCA6	23460	broad.mit.edu	37	17	67083559	67083559	+	Missense_Mutation	SNP	C	C	G			TCGA-F7-A622-01A-11D-A28R-08	TCGA-F7-A622-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1188c0e9-1f41-4b7e-8bfb-b6ad5a724466	46f9d879-7a87-4b25-adcb-bc10db818781	g.chr17:67083559C>G	ENST00000284425.2	-	29	3928	c.3754G>C	c.(3754-3756)Gat>Cat	p.D1252H	ABCA6_ENST00000446604.2_5'UTR	NM_080284.2	NP_525023.2	Q8N139	ABCA6_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 6	1252					transport	integral to membrane	ATP binding|ATPase activity			breast(6)|endometrium(5)|kidney(17)|large_intestine(18)|lung(20)|ovary(3)|prostate(2)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	82	Breast(10;5.65e-12)					ATATCTTCATCTTCATCTATG	0.373000													4	118					0	0	1	0	0
LRRIQ1	84125	broad.mit.edu	37	12	85518261	85518261	+	Missense_Mutation	SNP	T	T	G			TCGA-F7-A622-01A-11D-A28R-08	TCGA-F7-A622-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1188c0e9-1f41-4b7e-8bfb-b6ad5a724466	46f9d879-7a87-4b25-adcb-bc10db818781	g.chr12:85518261T>G	ENST00000393217.2	+	17	4032	c.3971T>G	c.(3970-3972)cTg>cGg	p.L1324R		NM_001079910.1	NP_001073379.1	Q96JM4	LRIQ1_HUMAN	leucine-rich repeats and IQ motif containing 1	1324										breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(21)|liver(1)|lung(28)|ovary(5)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)	83				GBM - Glioblastoma multiforme(134;0.212)		AATTCTTTGCTGAGGAATCAC	0.318000													8	219					0	0	1	0	0
BCHE	590	broad.mit.edu	37	3	165548003	165548003	+	Silent	SNP	G	G	A			TCGA-F7-A622-01A-11D-A28R-08	TCGA-F7-A622-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1188c0e9-1f41-4b7e-8bfb-b6ad5a724466	46f9d879-7a87-4b25-adcb-bc10db818781	g.chr3:165548003G>A	ENST00000264381.3	-	2	985	c.819C>T	c.(817-819)aaC>aaT	p.N273N	BCHE_ENST00000540653.1_Intron	NM_000055.2	NP_000046.1	P06276	CHLE_HUMAN	butyrylcholinesterase	273					choline metabolic process|cocaine metabolic process|synaptic transmission, cholinergic	endoplasmic reticulum lumen|extracellular space|membrane	acetylcholinesterase activity|beta-amyloid binding|carboxylesterase activity|cholinesterase activity|enzyme binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(10)|lung(34)|ovary(4)|pancreas(2)|stomach(1)	55					Ambenonium(DB01122)|Atropine(DB00572)|Bambuterol(DB01408)|Chlorpromazine(DB00477)|Choline(DB00122)|Cinnarizine(DB00568)|Demecarium bromide(DB00944)|Dibucaine(DB00527)|Donepezil(DB00843)|Echothiophate Iodide(DB01057)|Edrophonium(DB01010)|Ethopropazine(DB00392)|Etomidate(DB00292)|Galantamine(DB00674)|Hexafluronium bromide(DB00941)|Isoflurophate(DB00677)|Mefloquine(DB00358)|Mivacurium(DB01226)|Neostigmine(DB01400)|Pancuronium(DB01337)|Pralidoxime(DB00733)|Procainamide(DB01035)|Pyridostigmine(DB00545)|Rivastigmine(DB00989)|Succinylcholine(DB00202)|Terbutaline(DB00871)|Trimethaphan(DB01116)	ATTTAGCTAAGTTCAACGTTC	0.393000													62	53					0	0	1	0	0
REST	5978	broad.mit.edu	37	4	57777618	57777618	+	Missense_Mutation	SNP	C	C	A			TCGA-F7-A622-01A-11D-A28R-08	TCGA-F7-A622-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1188c0e9-1f41-4b7e-8bfb-b6ad5a724466	46f9d879-7a87-4b25-adcb-bc10db818781	g.chr4:57777618C>A	ENST00000309042.7	+	2	1128	c.814C>A	c.(814-816)Cca>Aca	p.P272T	REST_ENST00000514063.1_3'UTR	NM_001193508.1|NM_005612.4	NP_001180437.1|NP_005603.3	Q13127	REST_HUMAN	RE1-silencing transcription factor	272					cardiac muscle cell myoblast differentiation|cellular response to drug|cellular response to electrical stimulus|cellular response to glucocorticoid stimulus|histone H4 deacetylation|negative regulation by host of viral transcription|negative regulation of aldosterone biosynthetic process|negative regulation of calcium ion-dependent exocytosis|negative regulation of cell proliferation|negative regulation of cortisol biosynthetic process|negative regulation of dense core granule biogenesis|negative regulation of insulin secretion|negative regulation of mesenchymal stem cell differentiation|negative regulation of neurogenesis|negative regulation of neuron differentiation|positive regulation of apoptosis|positive regulation of caspase activity|positive regulation of transcription, DNA-dependent	cytoplasm|transcriptional repressor complex	calcium channel activity|chromatin binding|core promoter proximal region sequence-specific DNA binding|core promoter sequence-specific DNA binding|outward rectifier potassium channel activity|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|zinc ion binding			central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|liver(2)|lung(22)|ovary(1)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	50	Glioma(25;0.08)|all_neural(26;0.181)					AAACCATTTTCCAAGGAAAGT	0.378000													13	35					9.31168e-06	9.85306e-06	1	1	0
LYST	1130	broad.mit.edu	37	1	235969554	235969554	+	Missense_Mutation	SNP	G	G	C			TCGA-F7-A622-01A-11D-A28R-08	TCGA-F7-A622-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1188c0e9-1f41-4b7e-8bfb-b6ad5a724466	46f9d879-7a87-4b25-adcb-bc10db818781	g.chr1:235969554G>C	ENST00000389794.3	-	6	3056	c.2882C>G	c.(2881-2883)gCa>gGa	p.A961G	LYST_ENST00000389793.2_Missense_Mutation_p.A961G|LYST_ENST00000536965.1_Missense_Mutation_p.A961G			Q99698	LYST_HUMAN	lysosomal trafficking regulator	961					defense response to bacterium|defense response to protozoan|defense response to virus|endosome to lysosome transport via multivesicular body sorting pathway|leukocyte chemotaxis|mast cell secretory granule organization|melanosome organization|natural killer cell mediated cytotoxicity|protein transport	cytoplasm|microtubule cytoskeleton	protein binding			NS(1)|breast(13)|central_nervous_system(3)|cervix(3)|endometrium(17)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(27)|lung(66)|ovary(7)|pancreas(1)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	162	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.00246)|Prostate(94;0.0771)|Acute lymphoblastic leukemia(190;0.228)	OV - Ovarian serous cystadenocarcinoma(106;0.000674)			CCAAATGTCTGCTGCTTGGTG	0.448000													33	105					0	0	1	0	0
ADH5	128	broad.mit.edu	37	4	99997692	99997692	+	Silent	SNP	G	G	A			TCGA-F7-A622-01A-11D-A28R-08	TCGA-F7-A622-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1188c0e9-1f41-4b7e-8bfb-b6ad5a724466	46f9d879-7a87-4b25-adcb-bc10db818781	g.chr4:99997692G>A	ENST00000296412.8	-	6	626	c.576C>T	c.(574-576)ggC>ggT	p.G192G	ADH5_ENST00000512991.1_5'UTR	NM_000671.3	NP_000662.3	P11766	ADHX_HUMAN	alcohol dehydrogenase 5 (class III), chi polypeptide	192					ethanol oxidation|response to redox state		alcohol dehydrogenase (NAD) activity|electron carrier activity|fatty acid binding|formaldehyde dehydrogenase activity|S-(hydroxymethyl)glutathione dehydrogenase activity|zinc ion binding			endometrium(1)|kidney(1)|large_intestine(2)|lung(7)|ovary(1)|prostate(1)	13				OV - Ovarian serous cystadenocarcinoma(123;2.5e-07)	NADH(DB00157)	CACAAACAGAGCCAGGCTCCA	0.453000													24	30					0	0	1	0	0
MCTP2	55784	broad.mit.edu	37	15	94841761	94841761	+	Silent	SNP	C	C	T			TCGA-F7-A622-01A-11D-A28R-08	TCGA-F7-A622-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1188c0e9-1f41-4b7e-8bfb-b6ad5a724466	46f9d879-7a87-4b25-adcb-bc10db818781	g.chr15:94841761C>T	ENST00000357742.4	+	1	267	c.267C>T	c.(265-267)ccC>ccT	p.P89P	MCTP2_ENST00000331706.4_5'UTR|MCTP2_ENST00000451018.3_Silent_p.P89P|MCTP2_ENST00000543482.1_Silent_p.P89P	NM_018349.3	NP_060819.3	Q6DN12	MCTP2_HUMAN	multiple C2 domains, transmembrane 2	89					calcium-mediated signaling	integral to membrane|membrane fraction	calcium ion binding			autonomic_ganglia(1)|breast(4)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(12)|liver(1)|lung(12)|ovary(1)|pancreas(1)|skin(9)|stomach(2)	49	Lung NSC(78;0.0821)|all_lung(78;0.148)		BRCA - Breast invasive adenocarcinoma(143;0.0323)|OV - Ovarian serous cystadenocarcinoma(32;0.0593)			GGATCTTTCCCAAGAGCAGCA	0.577000													94	24					0	0	1	0	0
GPR156	165829	broad.mit.edu	37	3	119887190	119887190	+	Silent	SNP	G	G	A			TCGA-F7-A622-01A-11D-A28R-08	TCGA-F7-A622-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1188c0e9-1f41-4b7e-8bfb-b6ad5a724466	46f9d879-7a87-4b25-adcb-bc10db818781	g.chr3:119887190G>A	ENST00000464295.1	-	10	1579	c.1134C>T	c.(1132-1134)aaC>aaT	p.N378N	GPR156_ENST00000315843.3_Silent_p.N378N|GPR156_ENST00000461057.1_Silent_p.N374N			Q8NFN8	GP156_HUMAN	G protein-coupled receptor 156	378						integral to membrane|plasma membrane	G-protein coupled receptor activity|GABA-B receptor activity			breast(2)|endometrium(3)|kidney(1)|large_intestine(11)|lung(12)|ovary(1)|prostate(1)|skin(1)	32				GBM - Glioblastoma multiforme(114;0.19)		TCTCTTTGGCGTTGTTTACTT	0.507000													24	63					0	0	1	0	0
COL1A1	1277	broad.mit.edu	37	17	48267696	48267696	+	Missense_Mutation	SNP	C	C	A	rs74315133		TCGA-F7-A622-01A-11D-A28R-08	TCGA-F7-A622-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1188c0e9-1f41-4b7e-8bfb-b6ad5a724466	46f9d879-7a87-4b25-adcb-bc10db818781	g.chr17:48267696C>A	ENST00000225964.5	-	35	2561	c.2443G>T	c.(2443-2445)Ggc>Tgc	p.G815C		NM_000088.3	NP_000079.2	P02452	CO1A1_HUMAN	collagen, type I, alpha 1	815	Triple-helical region.		G -> V (in OI2A).		axon guidance|blood vessel development|collagen biosynthetic process|collagen fibril organization|embryonic skeletal system development|leukocyte migration|platelet activation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell migration|positive regulation of epithelial to mesenchymal transition|positive regulation of transcription, DNA-dependent|protein localization to nucleus|sensory perception of sound|skin morphogenesis|tooth mineralization|visual perception	collagen type I|extracellular space|plasma membrane	identical protein binding|platelet-derived growth factor binding		COL1A1/PDGFB(429)	NS(1)|breast(3)|central_nervous_system(8)|endometrium(3)|kidney(4)|large_intestine(17)|liver(3)|lung(18)|ovary(1)|pancreas(1)|prostate(4)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	71					Collagenase(DB00048)|Palifermin(DB00039)	ACAGGGGGGCCAGCAAAGCCA	0.607000			T	"""PDGFB, USP6"""	"""dermatofibrosarcoma protuberans, aneurysmal bone cyst """		Osteogenesis imperfecta						31	56					3.11337e-16	3.41346e-16	1	1	0
RASGRF1	5923	broad.mit.edu	37	15	79307681	79307681	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A622-01A-11D-A28R-08	TCGA-F7-A622-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1188c0e9-1f41-4b7e-8bfb-b6ad5a724466	46f9d879-7a87-4b25-adcb-bc10db818781	g.chr15:79307681G>A	ENST00000419573.3	-	13	2088	c.1814C>T	c.(1813-1815)cCg>cTg	p.P605L	RASGRF1_ENST00000560334.1_5'UTR|RASGRF1_ENST00000558480.2_Missense_Mutation_p.P605L	NM_002891.4	NP_002882.3	Q13972	RGRF1_HUMAN	Ras protein-specific guanine nucleotide-releasing factor 1	605					activation of Rac GTPase activity|apoptosis|induction of apoptosis by extracellular signals|long-term memory|nerve growth factor receptor signaling pathway|neuron projection development|regulation of Rac protein signal transduction|small GTPase mediated signal transduction|synaptic transmission	cytosol|growth cone|plasma membrane|synaptosome	Rho guanyl-nucleotide exchange factor activity			breast(2)|central_nervous_system(2)|endometrium(7)|kidney(4)|large_intestine(18)|lung(23)|ovary(2)|prostate(6)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	71						GATCATCTGCGGCACAGTGAC	0.517000													47	18					0	0	1	0	0
FAR1	84188	broad.mit.edu	37	11	13721993	13721993	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A622-01A-11D-A28R-08	TCGA-F7-A622-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1188c0e9-1f41-4b7e-8bfb-b6ad5a724466	46f9d879-7a87-4b25-adcb-bc10db818781	g.chr11:13721993A>G	ENST00000354817.3	+	3	463	c.319A>G	c.(319-321)Att>Gtt	p.I107V		NM_032228.5	NP_115604.1	Q8WVX9	FACR1_HUMAN	fatty acyl CoA reductase 1	107					ether lipid biosynthetic process	integral to membrane|peroxisomal matrix|peroxisomal membrane	protein binding			breast(1)|endometrium(1)|kidney(3)|large_intestine(1)|liver(1)|lung(3)|ovary(1)|prostate(1)|skin(1)	13						TTCTACCAATATTATATTCCA	0.303000													17	44					0	0	1	0	0
NDE1	54820	broad.mit.edu	37	16	15758653	15758653	+	Missense_Mutation	SNP	G	G	C			TCGA-F7-A622-01A-11D-A28R-08	TCGA-F7-A622-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1188c0e9-1f41-4b7e-8bfb-b6ad5a724466	46f9d879-7a87-4b25-adcb-bc10db818781	g.chr16:15758653G>C	ENST00000396355.1	+	3	844	c.18G>C	c.(16-18)aaG>aaC	p.K6N	NDE1_ENST00000342673.5_Missense_Mutation_p.K6N|NDE1_ENST00000396354.1_Missense_Mutation_p.K6N|NDE1_ENST00000396353.2_Missense_Mutation_p.K6N	NM_001143979.1	NP_001137451.1	Q9NXR1	NDE1_HUMAN	nudE neurodevelopment protein 1	6	Self-association (By similarity).				cell differentiation|cell division|centrosome duplication|establishment of chromosome localization|establishment of mitotic spindle orientation|G2/M transition of mitotic cell cycle|mitotic prometaphase|nervous system development	cleavage furrow|condensed chromosome kinetochore|cytosol|microtubule|spindle pole centrosome	microtubule binding			endometrium(3)|kidney(3)|large_intestine(1)|lung(5)|ovary(1)	13						ACTCCGGAAAGACTTTCAGCT	0.453000													33	178					0	0	1	0	0
COLEC11	78989	broad.mit.edu	37	2	3691474	3691474	+	Silent	SNP	G	G	T			TCGA-F7-A622-01A-11D-A28R-08	TCGA-F7-A622-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1188c0e9-1f41-4b7e-8bfb-b6ad5a724466	46f9d879-7a87-4b25-adcb-bc10db818781	g.chr2:3691474G>T	ENST00000403096.3	+	6	995	c.504G>T	c.(502-504)gcG>gcT	p.A168A	COLEC11_ENST00000402922.1_Silent_p.A144A|COLEC11_ENST00000487365.1_3'UTR|COLEC11_ENST00000404205.1_Silent_p.A120A|COLEC11_ENST00000402794.1_Silent_p.A144A|COLEC11_ENST00000382062.2_Silent_p.A170A|COLEC11_ENST00000349077.4_Silent_p.A194A|COLEC11_ENST00000236693.7_Silent_p.A191A|COLEC11_ENST00000418971.2_Silent_p.A208A	NM_001255986.1	NP_001242915.1	Q9BWP8	COL11_HUMAN	collectin sub-family member 11	194	C-type lectin.					collagen	mannose binding			central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(10)|ovary(1)|skin(1)|soft_tissue(1)	22	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.093)			OV - Ovarian serous cystadenocarcinoma(76;0.127)		CATACCTGGCGCAAGCCGGCC	0.662000													24	54					2.52088e-20	2.79756e-20	1	1	0
ARHGAP39	80728	broad.mit.edu	37	8	145756232	145756232	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A622-01A-11D-A28R-08	TCGA-F7-A622-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1188c0e9-1f41-4b7e-8bfb-b6ad5a724466	46f9d879-7a87-4b25-adcb-bc10db818781	g.chr8:145756232G>A	ENST00000276826.5	-	9	3112	c.2911C>T	c.(2911-2913)Cgg>Tgg	p.R971W	ARHGAP39_ENST00000377307.2_Missense_Mutation_p.R1002W|ARHGAP39_ENST00000540274.1_Missense_Mutation_p.R971W			Q9C0H5	RHG39_HUMAN	Rho GTPase activating protein 39	971	Rho-GAP.				axon guidance|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytoskeleton|cytosol|nucleus	GTPase activator activity			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(11)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	22						TCCAGCTCCCGGTACCACAGC	0.711000													11	64					0	0	1	0	0
GPR68	8111	broad.mit.edu	37	14	91701363	91701363	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A622-01A-11D-A28R-08	TCGA-F7-A622-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1188c0e9-1f41-4b7e-8bfb-b6ad5a724466	46f9d879-7a87-4b25-adcb-bc10db818781	g.chr14:91701363A>G	ENST00000535815.1	-	2	372	c.32T>C	c.(31-33)aTg>aCg	p.M11T	GPR68_ENST00000238699.3_Missense_Mutation_p.M21T|GPR68_ENST00000531499.2_Missense_Mutation_p.M11T	NM_001177676.1	NP_001171147.1	Q15743	OGR1_HUMAN	G protein-coupled receptor 68	11					inflammatory response	integral to plasma membrane	G-protein coupled receptor activity			central_nervous_system(2)|endometrium(1)|kidney(1)|lung(2)|skin(1)|urinary_tract(1)	8		all_cancers(154;0.0555)		COAD - Colon adenocarcinoma(157;0.21)		GGTACAGCTCATCGAGGAGTT	0.612000													20	47					0	0	1	0	0
PRICKLE3	4007	broad.mit.edu	37	X	49032432	49032432	+	Missense_Mutation	SNP	G	G	T			TCGA-F7-A622-01A-11D-A28R-08	TCGA-F7-A622-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1188c0e9-1f41-4b7e-8bfb-b6ad5a724466	46f9d879-7a87-4b25-adcb-bc10db818781	g.chrX:49032432G>T	ENST00000376317.3	-	9	1532	c.1438C>A	c.(1438-1440)Ctg>Atg	p.L480M	PRICKLE3_ENST00000540849.1_Missense_Mutation_p.L412M|PRICKLE3_ENST00000536904.1_Missense_Mutation_p.L399M|PRICKLE3_ENST00000538114.1_Missense_Mutation_p.L316M	NM_006150.3	NP_006141.2	O43900	PRIC3_HUMAN	prickle homolog 3 (Drosophila)	480				Missing (in Ref. 5; AAB92357).			protein binding|zinc ion binding			breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(8)|skin(2)	22						TCAGACACCAGAGGGTCGCGG	0.741000													5	7					0.000602214	0.000615747	1	1	0
HMCN1	83872	broad.mit.edu	37	1	186114938	186114938	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A622-01A-11D-A28R-08	TCGA-F7-A622-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1188c0e9-1f41-4b7e-8bfb-b6ad5a724466	46f9d879-7a87-4b25-adcb-bc10db818781	g.chr1:186114938G>A	ENST00000271588.4	+	93	14720	c.14491G>A	c.(14491-14493)Gga>Aga	p.G4831R	HMCN1_ENST00000367492.2_Missense_Mutation_p.G4831R	NM_031935.2	NP_114141.2	Q96RW7	HMCN1_HUMAN	hemicentin 1	4831	TSP type-1 6.				response to stimulus|visual perception	basement membrane	calcium ion binding			NS(2)|autonomic_ganglia(1)|breast(10)|central_nervous_system(2)|cervix(1)|endometrium(28)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(58)|liver(3)|lung(101)|ovary(23)|pancreas(4)|prostate(20)|skin(8)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(18)	308						TGCCTCCTGTGGAGGAGGTGA	0.532000													37	96					0	0	1	0	0
TGFBR2	7048	broad.mit.edu	37	3	30732969	30732969	+	Missense_Mutation	SNP	C	C	T	rs104893810		TCGA-F7-A622-01A-11D-A28R-08	TCGA-F7-A622-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1188c0e9-1f41-4b7e-8bfb-b6ad5a724466	46f9d879-7a87-4b25-adcb-bc10db818781	g.chr3:30732969C>T	ENST00000295754.5	+	7	1964	c.1582C>T	c.(1582-1584)Cgt>Tgt	p.R528C	TGFBR2_ENST00000359013.4_Missense_Mutation_p.R553C	NM_003242.5	NP_003233.4	P37173	TGFR2_HUMAN	transforming growth factor, beta receptor II (70/80kDa)	528	Protein kinase.		R -> C (in LDS1B).|R -> H (in LDS1B).		activation of protein kinase activity|brain development|embryonic cranial skeleton morphogenesis|embryonic hemopoiesis|heart development|myeloid dendritic cell differentiation|palate development|pathway-restricted SMAD protein phosphorylation|patterning of blood vessels|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of B cell tolerance induction|positive regulation of mesenchymal cell proliferation|positive regulation of NK T cell differentiation|positive regulation of reactive oxygen species metabolic process|positive regulation of T cell tolerance induction|positive regulation of tolerance induction to self antigen|response to cholesterol|response to drug|transforming growth factor beta receptor signaling pathway|vasculogenesis	caveola|external side of plasma membrane	ATP binding|glycosaminoglycan binding|metal ion binding|protein binding|receptor signaling protein serine/threonine kinase activity|SMAD binding|transforming growth factor beta binding|transforming growth factor beta receptor activity, type II|type I transforming growth factor beta receptor binding|type III transforming growth factor beta receptor binding	p.R528C(2)		breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(15)|lung(10)|ovary(3)|pancreas(12)|skin(1)|stomach(5)|upper_aerodigestive_tract(2)	53						CCCAGAGGCCCGTCTCACAGC	0.597000													28	36					0	0	1	0	0
SUPT16H	11198	broad.mit.edu	37	14	21837411	21837411	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A622-01A-11D-A28R-08	TCGA-F7-A622-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1188c0e9-1f41-4b7e-8bfb-b6ad5a724466	46f9d879-7a87-4b25-adcb-bc10db818781	g.chr14:21837411G>A	ENST00000216297.2	-	6	1072	c.734C>T	c.(733-735)cCt>cTt	p.P245L		NM_007192.3	NP_009123.1	Q9Y5B9	SP16H_HUMAN	suppressor of Ty 16 homolog (S. cerevisiae)	245					DNA repair|DNA replication|nucleosome disassembly|positive regulation of transcription elongation, DNA-dependent|positive regulation of viral transcription|transcription elongation from RNA polymerase II promoter|viral reproduction	chromosome|nucleoplasm	GTP binding			breast(3)|endometrium(4)|kidney(1)|large_intestine(9)|lung(6)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	27	all_cancers(95;0.00115)		Epithelial(56;1.62e-06)|all cancers(55;1.49e-05)	GBM - Glioblastoma multiforme(265;0.0159)		CTGAATGATAGGAGGGTAACA	0.408000													23	47					0	0	1	0	0
FAM193A	8603	broad.mit.edu	37	4	2632856	2632856	+	Missense_Mutation	SNP	G	G	C			TCGA-F7-A622-01A-11D-A28R-08	TCGA-F7-A622-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1188c0e9-1f41-4b7e-8bfb-b6ad5a724466	46f9d879-7a87-4b25-adcb-bc10db818781	g.chr4:2632856G>C	ENST00000324666.5	+	3	476	c.125G>C	c.(124-126)tGc>tCc	p.C42S	FAM193A_ENST00000505311.1_Missense_Mutation_p.C42S|FAM193A_ENST00000502458.1_Missense_Mutation_p.C42S|FAM193A_ENST00000382839.3_Missense_Mutation_p.C42S|FAM193A_ENST00000545951.1_Missense_Mutation_p.C42S	NM_001256666.1	NP_001243595.1	P78312	F193A_HUMAN	family with sequence similarity 193, member A	42										NS(2)|breast(1)|endometrium(4)|kidney(4)|large_intestine(3)|lung(12)|ovary(4)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(3)	40						GGCGCCCTCTGCCAGGCCGCA	0.587000													15	86					0	0	1	0	0
DSCAML1	57453	broad.mit.edu	37	11	117391933	117391933	+	Silent	SNP	C	C	T	rs147591517		TCGA-F7-A622-01A-11D-A28R-08	TCGA-F7-A622-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1188c0e9-1f41-4b7e-8bfb-b6ad5a724466	46f9d879-7a87-4b25-adcb-bc10db818781	g.chr11:117391933C>T	ENST00000321322.6	-	6	1306	c.1305G>A	c.(1303-1305)tcG>tcA	p.S435S	DSCAML1_ENST00000527706.1_Silent_p.S165S	NM_020693.2	NP_065744.2	Q8TD84	DSCL1_HUMAN	Down syndrome cell adhesion molecule like 1	375	Ig-like C2-type 5.				axonogenesis|brain development|cell fate determination|dorsal/ventral pattern formation|embryonic skeletal system morphogenesis|homophilic cell adhesion	cell surface|integral to membrane|plasma membrane	protein homodimerization activity			breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|large_intestine(24)|lung(49)|ovary(6)|pancreas(1)|prostate(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	110	all_hematologic(175;0.0487)	Breast(348;0.0424)|Medulloblastoma(222;0.0523)|all_hematologic(192;0.232)		BRCA - Breast invasive adenocarcinoma(274;9.12e-06)|Epithelial(105;0.00172)		TCTTCTGGGCCGAGGTGATGA	0.632000													66	211					0	0	1	0	0
HTR3C	170572	broad.mit.edu	37	3	183777668	183777668	+	Silent	SNP	C	C	T			TCGA-F7-A622-01A-11D-A28R-08	TCGA-F7-A622-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1188c0e9-1f41-4b7e-8bfb-b6ad5a724466	46f9d879-7a87-4b25-adcb-bc10db818781	g.chr3:183777668C>T	ENST00000318351.1	+	8	1012	c.978C>T	c.(976-978)acC>acT	p.T326T		NM_130770.2	NP_570126.2	Q8WXA8	5HT3C_HUMAN	5-hydroxytryptamine (serotonin) receptor 3C, ionotropic	326						integral to membrane|plasma membrane|postsynaptic membrane	extracellular ligand-gated ion channel activity|receptor activity			central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(14)|ovary(1)|prostate(1)|skin(2)|stomach(2)	32	all_cancers(143;2.33e-10)|Ovarian(172;0.0303)		Epithelial(37;1.74e-35)|OV - Ovarian serous cystadenocarcinoma(80;3.11e-22)			TGCTGGAGACCGTCTTCATTA	0.562000													32	140					0	0	1	0	0
KMT2B	9757	broad.mit.edu	37	19	36221489	36221489	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A622-01A-11D-A28R-08	TCGA-F7-A622-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1188c0e9-1f41-4b7e-8bfb-b6ad5a724466	46f9d879-7a87-4b25-adcb-bc10db818781	g.chr19:36221489G>A	ENST00000420124.1	+	25	5248	c.5248G>A	c.(5248-5250)Gag>Aag	p.E1750K	KMT2B_ENST00000607650.1_RNA|WBP7_ENST00000222270.7_Missense_Mutation_p.E1750K																							CTCGGACTGCGAGGGACGGCT	0.607000													7	393					0	0	1	0	0
C4orf22	255119	broad.mit.edu	37	4	81504291	81504291	+	Missense_Mutation	SNP	C	C	T	rs142731425	byFrequency	TCGA-F7-A622-01A-11D-A28R-08	TCGA-F7-A622-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1188c0e9-1f41-4b7e-8bfb-b6ad5a724466	46f9d879-7a87-4b25-adcb-bc10db818781	g.chr4:81504291C>T	ENST00000358105.3	+	3	336	c.287C>T	c.(286-288)aCg>aTg	p.T96M	C4orf22_ENST00000512931.1_3'UTR|C4orf22_ENST00000508675.1_Missense_Mutation_p.T96M	NM_152770.2	NP_689983.2	Q6V702	CD022_HUMAN	chromosome 4 open reading frame 22	96										NS(1)|large_intestine(3)|lung(5)|prostate(1)|skin(5)	15						AATTTTCTGACGGCCCTGGCA	0.353000													14	55					0	0	1	0	0
MYH10	4628	broad.mit.edu	37	17	8393845	8393845	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A622-01A-11D-A28R-08	TCGA-F7-A622-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1188c0e9-1f41-4b7e-8bfb-b6ad5a724466	46f9d879-7a87-4b25-adcb-bc10db818781	g.chr17:8393845C>T	ENST00000360416.3	-	35	4835	c.4697G>A	c.(4696-4698)cGg>cAg	p.R1566Q	MYH10_ENST00000396239.1_Missense_Mutation_p.R1556Q|MYH10_ENST00000379980.4_Missense_Mutation_p.R1551Q|MYH10_ENST00000269243.4_Missense_Mutation_p.R1535Q	NM_001256012.1	NP_001242941.1	P35580	MYH10_HUMAN	myosin, heavy chain 10, non-muscle	1535					actin filament-based movement|axon guidance|cytokinesis after mitosis|regulation of cell shape	cell cortex|cleavage furrow|midbody|myosin complex|stress fiber	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity			breast(5)|endometrium(9)|kidney(2)|large_intestine(16)|lung(9)|ovary(3)|prostate(3)|skin(4)|stomach(1)	52						CTCTAGGGCCCGTTTGGATTT	0.522000													4	94					0	0	1	0	0
FRY	10129	broad.mit.edu	37	13	32812053	32812053	+	Silent	SNP	G	G	T			TCGA-F7-A622-01A-11D-A28R-08	TCGA-F7-A622-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1188c0e9-1f41-4b7e-8bfb-b6ad5a724466	46f9d879-7a87-4b25-adcb-bc10db818781	g.chr13:32812053G>T	ENST00000380250.3	+	44	6844	c.6348G>T	c.(6346-6348)ctG>ctT	p.L2116L		NM_023037.2	NP_075463.2	Q5TBA9	FRY_HUMAN	furry homolog (Drosophila)	2116					regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to membrane				NS(3)|breast(4)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(31)|lung(50)|ovary(5)|pancreas(1)|prostate(6)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	132		Lung SC(185;0.0271)		all cancers(112;4.81e-05)|Epithelial(112;0.000656)|OV - Ovarian serous cystadenocarcinoma(117;0.0123)|BRCA - Breast invasive adenocarcinoma(63;0.0295)|GBM - Glioblastoma multiforme(144;0.104)		CCACAGACCTGACCCTGCAGC	0.542000													43	86					9.39024e-22	1.05495e-21	1	1	0
BTBD7	55727	broad.mit.edu	37	14	93760714	93760714	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A622-01A-11D-A28R-08	TCGA-F7-A622-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1188c0e9-1f41-4b7e-8bfb-b6ad5a724466	46f9d879-7a87-4b25-adcb-bc10db818781	g.chr14:93760714C>T	ENST00000334746.5	-	3	959	c.652G>A	c.(652-654)Gat>Aat	p.D218N	BTBD7_ENST00000555525.1_Missense_Mutation_p.D218N|BTBD7_ENST00000554565.1_Intron|BTBD7_ENST00000298896.3_Missense_Mutation_p.D218N	NM_001002860.2	NP_001002860.2	Q9P203	BTBD7_HUMAN	BTB (POZ) domain containing 7	218										breast(1)|endometrium(3)|kidney(3)|large_intestine(9)|lung(8)|ovary(1)|pancreas(1)|skin(8)|upper_aerodigestive_tract(1)	35		all_cancers(154;0.08)		Epithelial(152;0.196)|COAD - Colon adenocarcinoma(157;0.212)|all cancers(159;0.223)		ACAAGGATATCGACATTTTGA	0.383000													18	33					0	0	1	0	0
EVX2	344191	broad.mit.edu	37	2	176948135	176948135	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A622-01A-11D-A28R-08	TCGA-F7-A622-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1188c0e9-1f41-4b7e-8bfb-b6ad5a724466	46f9d879-7a87-4b25-adcb-bc10db818781	g.chr2:176948135C>T	ENST00000308618.4	-	1	506	c.370G>A	c.(370-372)Gcg>Acg	p.A124T		NM_001080458.1	NP_001073927.1	Q03828	EVX2_HUMAN	even-skipped homeobox 2	124						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			kidney(1)|large_intestine(3)|liver(1)|lung(8)|ovary(3)	16			OV - Ovarian serous cystadenocarcinoma(117;0.0207)|Epithelial(96;0.18)	READ - Rectum adenocarcinoma(9;0.0678)|Colorectal(32;0.115)		GAGCGAAGCGCGGAGCAGCCC	0.672000													9	26					0	0	1	0	0
GUCY2C	2984	broad.mit.edu	37	12	14827630	14827630	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A622-01A-11D-A28R-08	TCGA-F7-A622-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1188c0e9-1f41-4b7e-8bfb-b6ad5a724466	46f9d879-7a87-4b25-adcb-bc10db818781	g.chr12:14827630A>G	ENST00000261170.3	-	8	1149	c.1013T>C	c.(1012-1014)aTa>aCa	p.I338T	RP11-174G6.1_ENST00000501178.2_RNA	NM_004963.3	NP_004954.2	P25092	GUC2C_HUMAN	guanylate cyclase 2C (heat stable enterotoxin receptor)	338					intracellular signal transduction|receptor guanylyl cyclase signaling pathway	integral to membrane	ATP binding|GTP binding|guanylate cyclase activity|protein binding|protein kinase activity|receptor activity			breast(3)|endometrium(7)|kidney(3)|large_intestine(9)|lung(17)|ovary(4)|skin(7)|urinary_tract(1)	51						TTCAAGAAATATCTTCAGCAT	0.368000													41	72					0	0	1	0	0
SHPRH	257218	broad.mit.edu	37	6	146273490	146273490	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A622-01A-11D-A28R-08	TCGA-F7-A622-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1188c0e9-1f41-4b7e-8bfb-b6ad5a724466	46f9d879-7a87-4b25-adcb-bc10db818781	g.chr6:146273490A>G	ENST00000367503.3	-	3	1156	c.758T>C	c.(757-759)aTt>aCt	p.I253T	SHPRH_ENST00000367505.2_Missense_Mutation_p.I253T|SHPRH_ENST00000275233.7_Missense_Mutation_p.I253T|SHPRH_ENST00000438092.2_Missense_Mutation_p.I253T	NM_001042683.2	NP_001036148.2	Q149N8	SHPRH_HUMAN	SNF2 histone linker PHD RING helicase, E3 ubiquitin protein ligase	253					DNA repair|nucleosome assembly	nucleosome|nucleus	ATP binding|DNA binding|helicase activity|ligase activity|zinc ion binding			breast(2)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(15)|lung(33)|ovary(3)|pancreas(2)|prostate(7)|skin(1)|urinary_tract(1)	79		Ovarian(120;0.0365)		OV - Ovarian serous cystadenocarcinoma(155;1.47e-07)|GBM - Glioblastoma multiforme(68;0.0124)		ATTACCTGGAATAATAGAATT	0.323000													6	7					0	0	1	0	0
LILRB3	11025	broad.mit.edu	37	19	54723046	54723046	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A622-01A-11D-A28R-08	TCGA-F7-A622-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1188c0e9-1f41-4b7e-8bfb-b6ad5a724466	46f9d879-7a87-4b25-adcb-bc10db818781	g.chr19:54723046G>A	ENST00000391750.1	-	9	1514	c.1378C>T	c.(1378-1380)Ctc>Ttc	p.L460F	LILRA6_ENST00000440558.2_Missense_Mutation_p.L460F|LILRA6_ENST00000419410.2_Missense_Mutation_p.L460F|LILRB3_ENST00000424807.1_Missense_Mutation_p.L460F|LILRB3_ENST00000407860.2_Missense_Mutation_p.L477F|LILRB3_ENST00000346401.6_Missense_Mutation_p.L472F|LILRA6_ENST00000270464.5_Missense_Mutation_p.L460F|LILRA6_ENST00000391735.3_3'UTR|LILRB3_ENST00000245620.9_Missense_Mutation_p.L460F|LILRB3_ENST00000469273.1_5'UTR			O75022	LIRB3_HUMAN	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3	460					cell surface receptor linked signaling pathway|defense response	integral to plasma membrane	transmembrane receptor activity			endometrium(3)|kidney(13)|large_intestine(1)|lung(6)|ovary(2)|prostate(5)|skin(2)|stomach(1)|urinary_tract(1)	34	all_cancers(19;0.00723)|all_epithelial(19;0.00389)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		aggaggaagaggaggaggaag	0.592000													4	26					0	0	1	0	0
CADM1	23705	broad.mit.edu	37	11	115080343	115080343	+	Silent	SNP	G	G	T			TCGA-F7-A622-01A-11D-A28R-08	TCGA-F7-A622-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1188c0e9-1f41-4b7e-8bfb-b6ad5a724466	46f9d879-7a87-4b25-adcb-bc10db818781	g.chr11:115080343G>T	ENST00000537058.1	-	8	1049	c.1029C>A	c.(1027-1029)acC>acA	p.T343T	CADM1_ENST00000452722.2_Silent_p.T343T|CADM1_ENST00000537140.1_Intron|CADM1_ENST00000542447.2_Intron|CADM1_ENST00000536727.1_Intron|CADM1_ENST00000331581.6_Silent_p.T343T			Q9BY67	CADM1_HUMAN	cell adhesion molecule 1	343				PPTTIPPPTTTTTTTTTTTTTILTIIT -> TTATTEPAVH GLTQLPNSAEELDSEDLS (in Ref. 3; BAC11657).	adherens junction organization|apoptosis|cell differentiation|cell junction assembly|cell recognition|detection of stimulus|heterophilic cell-cell adhesion|homophilic cell adhesion|multicellular organismal development|positive regulation of cytokine secretion|spermatogenesis|susceptibility to natural killer cell mediated cytotoxicity	basolateral plasma membrane|cell-cell junction|integral to membrane	PDZ domain binding|protein C-terminus binding|protein homodimerization activity|receptor binding	p.T343T(5)		cervix(1)|endometrium(4)|kidney(4)|large_intestine(11)|lung(9)|ovary(2)|skin(1)	32	all_hematologic(175;0.0628)	all_cancers(61;2.98e-14)|all_epithelial(67;2.64e-08)|all_hematologic(158;0.000154)|Melanoma(852;0.000952)|Acute lymphoblastic leukemia(157;0.00101)|Breast(348;0.0102)|Medulloblastoma(222;0.0429)|Prostate(24;0.145)|all_neural(223;0.237)		BRCA - Breast invasive adenocarcinoma(274;5.01e-06)|Epithelial(105;0.000305)|all cancers(92;0.00303)		tggtggtggtggttgttgtgg	0.433000													4	97					0.150653	0.150653	1	1	0
CHD2	1106	broad.mit.edu	37	15	93499774	93499774	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A622-01A-11D-A28R-08	TCGA-F7-A622-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1188c0e9-1f41-4b7e-8bfb-b6ad5a724466	46f9d879-7a87-4b25-adcb-bc10db818781	g.chr15:93499774C>T	ENST00000394196.4	+	16	2963	c.1895C>T	c.(1894-1896)aCt>aTt	p.T632I	CHD2_ENST00000557381.1_Missense_Mutation_p.T632I	NM_001271.3	NP_001262.3	O14647	CHD2_HUMAN	chromodomain helicase DNA binding protein 2	632	Helicase ATP-binding.				regulation of transcription from RNA polymerase II promoter	nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(5)|kidney(2)|large_intestine(10)|lung(17)|ovary(1)|prostate(2)|skin(2)|stomach(1)|urinary_tract(2)	47	Lung NSC(78;0.00976)|all_lung(78;0.016)		BRCA - Breast invasive adenocarcinoma(143;0.0282)|OV - Ovarian serous cystadenocarcinoma(32;0.0814)			TTGTATAAAACTCTGATTGAT	0.443000													4	77					0	0	1	0	0
ZNF468	90333	broad.mit.edu	37	19	53344032	53344032	+	Missense_Mutation	SNP	A	A	T			TCGA-F7-A622-01A-11D-A28R-08	TCGA-F7-A622-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1188c0e9-1f41-4b7e-8bfb-b6ad5a724466	46f9d879-7a87-4b25-adcb-bc10db818781	g.chr19:53344032A>T	ENST00000595646.1	-	4	1635	c.1515T>A	c.(1513-1515)agT>agA	p.S505R	ZNF468_ENST00000243639.4_3'UTR|ZNF468_ENST00000390651.4_Missense_Mutation_p.S452R|ZNF28_ENST00000594602.1_Intron|ZNF468_ENST00000396409.4_Missense_Mutation_p.S452R			Q5VIY5	ZN468_HUMAN	zinc finger protein 468	505					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(5)|lung(5)|ovary(2)|skin(1)|stomach(3)|urinary_tract(1)	23				GBM - Glioblastoma multiforme(134;0.0358)		ATGACATCTGACTGAAGGTCT	0.443000													56	118					0	0	1	0	0
OR4N2	390429	broad.mit.edu	37	14	20296135	20296135	+	Missense_Mutation	SNP	C	C	A			TCGA-F7-A622-01A-11D-A28R-08	TCGA-F7-A622-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1188c0e9-1f41-4b7e-8bfb-b6ad5a724466	46f9d879-7a87-4b25-adcb-bc10db818781	g.chr14:20296135C>A	ENST00000568211.1	+	1	528	c.528C>A	c.(526-528)aaC>aaA	p.N176K	OR4N2_ENST00000315947.1_Missense_Mutation_p.N176K			Q8NGD1	OR4N2_HUMAN	olfactory receptor, family 4, subfamily N, member 2	176					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|liver(1)|lung(32)|ovary(2)|prostate(1)|skin(2)|stomach(2)	52	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		AGCTGGACAACTTCTTCTGTG	0.527000													50	163					3.10996e-30	3.53758e-30	1	1	0
DNAH3	55567	broad.mit.edu	37	16	21156602	21156602	+	Missense_Mutation	SNP	C	C	A			TCGA-F7-A622-01A-11D-A28R-08	TCGA-F7-A622-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1188c0e9-1f41-4b7e-8bfb-b6ad5a724466	46f9d879-7a87-4b25-adcb-bc10db818781	g.chr16:21156602C>A	ENST00000261383.3	-	3	347	c.348G>T	c.(346-348)ttG>ttT	p.L116F	DNAH3_ENST00000575491.1_5'UTR|DNAH3_ENST00000415178.1_Missense_Mutation_p.L116F	NM_017539.1	NP_060009.1	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	116	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(3)|autonomic_ganglia(1)|breast(12)|central_nervous_system(3)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(42)|liver(2)|lung(57)|ovary(14)|pancreas(1)|prostate(7)|skin(11)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(6)	202				GBM - Glioblastoma multiforme(48;0.207)		CCTGGGCCATCAAGGAGTAGT	0.572000													4	37					0.00024832	0.000259737	1	1	0
DAB2IP	153090	broad.mit.edu	37	9	124535130	124535130	+	Nonsense_Mutation	SNP	C	C	T			TCGA-F7-A622-01A-11D-A28R-08	TCGA-F7-A622-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1188c0e9-1f41-4b7e-8bfb-b6ad5a724466	46f9d879-7a87-4b25-adcb-bc10db818781	g.chr9:124535130C>T	ENST00000408936.3	+	12	2505	c.2323C>T	c.(2323-2325)Cag>Tag	p.Q775*	DAB2IP_ENST00000309989.1_Nonsense_Mutation_p.Q651*|DAB2IP_ENST00000259371.2_Nonsense_Mutation_p.Q747*			Q5VWQ8	DAB2P_HUMAN	DAB2 interacting protein	775					activation of JUN kinase activity|apoptosis in response to endoplasmic reticulum stress|cellular response to epidermal growth factor stimulus|cellular response to tumor necrosis factor|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of catenin import into nucleus|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of epithelial cell migration|negative regulation of epithelial cell proliferation|negative regulation of epithelial to mesenchymal transition|negative regulation of fibroblast proliferation|negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of MAP kinase activity|negative regulation of NF-kappaB transcription factor activity|negative regulation of Ras GTPase activity|negative regulation of transcription from RNA polymerase II promoter|positive regulation of apoptosis|positive regulation of transcription from RNA polymerase II promoter	cytoplasm|intrinsic to internal side of plasma membrane	14-3-3 protein binding|death receptor binding|mitogen-activated protein kinase kinase kinase binding|protein homodimerization activity|protein phosphatase 2A binding|Ras GTPase activator activity|signaling adaptor activity			breast(3)|central_nervous_system(2)|cervix(1)|endometrium(3)|large_intestine(8)|lung(6)|ovary(1)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	27						CACAGATGGGCAGGCCGCTGC	0.741000													17	15					0	0	1	0	0
WDR33	55339	broad.mit.edu	37	2	128466386	128466386	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A622-01A-11D-A28R-08	TCGA-F7-A622-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1188c0e9-1f41-4b7e-8bfb-b6ad5a724466	46f9d879-7a87-4b25-adcb-bc10db818781	g.chr2:128466386G>A	ENST00000322313.4	-	21	3804	c.3646C>T	c.(3646-3648)Cgc>Tgc	p.R1216C		NM_018383.4	NP_060853.3	Q9C0J8	WDR33_HUMAN	WD repeat domain 33	1216					postreplication repair|spermatogenesis	collagen|nucleus	protein binding			NS(1)|breast(3)|endometrium(2)|kidney(2)|large_intestine(9)|lung(17)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	39	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0695)		GAAGAGGAGCGTTCTCTGCTG	0.567000													21	89					0	0	1	0	0
NLRP12	91662	broad.mit.edu	37	19	54313428	54313428	+	Silent	SNP	G	G	C			TCGA-F7-A622-01A-11D-A28R-08	TCGA-F7-A622-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1188c0e9-1f41-4b7e-8bfb-b6ad5a724466	46f9d879-7a87-4b25-adcb-bc10db818781	g.chr19:54313428G>C	ENST00000324134.6	-	3	1653	c.1485C>G	c.(1483-1485)ctC>ctG	p.L495L	NLRP12_ENST00000391775.3_Silent_p.L495L|NLRP12_ENST00000391772.1_Silent_p.L495L|NLRP12_ENST00000535162.1_Silent_p.L495L|NLRP12_ENST00000391773.1_Silent_p.L495L|NLRP12_ENST00000345770.5_Silent_p.L495L|NLRP12_ENST00000354278.3_Silent_p.L495L|NLRP12_ENST00000351894.4_Silent_p.L495L	NM_001277126.1|NM_144687.2	NP_001264055.1|NP_653288.1	P59046	NAL12_HUMAN	NLR family, pyrin domain containing 12	495	NACHT.				negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of interleukin-1 secretion|negative regulation of interleukin-6 biosynthetic process|negative regulation of protein autophosphorylation|negative regulation of Toll signaling pathway|positive regulation of inflammatory response|positive regulation of interleukin-1 beta secretion|regulation of interleukin-18 biosynthetic process|release of cytoplasmic sequestered NF-kappaB	cytoplasm	ATP binding|caspase activator activity|protein binding			NS(1)|breast(4)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|liver(1)|lung(36)|ovary(5)|pancreas(2)|skin(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	80	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.026)		TGTTCATGTTGAGGAAGGCAG	0.502000													6	144					0	0	1	0	0
SPATS1	221409	broad.mit.edu	37	6	44337830	44337830	+	Silent	SNP	G	G	A			TCGA-F7-A622-01A-11D-A28R-08	TCGA-F7-A622-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1188c0e9-1f41-4b7e-8bfb-b6ad5a724466	46f9d879-7a87-4b25-adcb-bc10db818781	g.chr6:44337830G>A	ENST00000288390.2	+	6	1085	c.738G>A	c.(736-738)gaG>gaA	p.E246E	SPATS1_ENST00000323108.8_Silent_p.E246E			Q496A3	SPAS1_HUMAN	spermatogenesis associated, serine-rich 1	246										NS(1)|central_nervous_system(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|liver(2)|lung(5)|skin(1)|urinary_tract(1)	14	all_lung(25;0.00469)|Ovarian(13;0.0273)|all_hematologic(164;0.208)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)			TTCCACTTGAGCCTCTTCCAC	0.343000													15	47					0	0	1	0	0
ZNF831	128611	broad.mit.edu	37	20	57769568	57769568	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A622-01A-11D-A28R-08	TCGA-F7-A622-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1188c0e9-1f41-4b7e-8bfb-b6ad5a724466	46f9d879-7a87-4b25-adcb-bc10db818781	g.chr20:57769568G>A	ENST00000371030.2	+	1	3494	c.3494G>A	c.(3493-3495)cGc>cAc	p.R1165H		NM_178457.1	NP_848552.1	Q5JPB2	ZN831_HUMAN	zinc finger protein 831	1165						intracellular	nucleic acid binding|zinc ion binding	p.R1165H(1)		NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(15)|lung(71)|ovary(2)|pancreas(1)|prostate(4)|skin(16)|upper_aerodigestive_tract(2)|urinary_tract(3)	125	all_lung(29;0.0085)					CACAGCACCCGCAGTCCCCAC	0.672000													4	153					0	0	1	0	0
ANO9	338440	broad.mit.edu	37	11	418799	418799	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A622-01A-11D-A28R-08	TCGA-F7-A622-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1188c0e9-1f41-4b7e-8bfb-b6ad5a724466	46f9d879-7a87-4b25-adcb-bc10db818781	g.chr11:418799C>T	ENST00000332826.6	-	22	2135	c.2051G>A	c.(2050-2052)cGc>cAc	p.R684H		NM_001012302.2	NP_001012302.2	A1A5B4	ANO9_HUMAN	anoctamin 9	684						chloride channel complex	chloride channel activity			central_nervous_system(2)|cervix(1)|endometrium(3)|kidney(1)|lung(5)|ovary(1)|prostate(4)|skin(4)	21						GGGGGGATTGCGGTAGTCCCT	0.577000													47	133					0	0	1	0	0
ENO3	2027	broad.mit.edu	37	17	4858480	4858480	+	Silent	SNP	C	C	T			TCGA-F7-A622-01A-11D-A28R-08	TCGA-F7-A622-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1188c0e9-1f41-4b7e-8bfb-b6ad5a724466	46f9d879-7a87-4b25-adcb-bc10db818781	g.chr17:4858480C>T	ENST00000323997.6	+	7	687	c.555C>T	c.(553-555)ggC>ggT	p.G185G	ENO3_ENST00000519584.1_Silent_p.G142G|ENO3_ENST00000518175.1_Silent_p.G185G	NM_001976.4|NM_053013.3	NP_001967.3|NP_443739.3	P13929	ENOB_HUMAN	enolase 3 (beta, muscle)	185					gluconeogenesis|glycolysis	phosphopyruvate hydratase complex	magnesium ion binding|phosphopyruvate hydratase activity			cervix(1)|endometrium(1)|large_intestine(4)|lung(8)|ovary(1)	15						TGCGCATTGGCGCCGAGGTCT	0.577000													4	103					0	0	1	0	0
AGRN	375790	broad.mit.edu	37	1	983661	983661	+	Frame_Shift_Del	DEL	G	G	-			TCGA-F7-A622-01A-11D-A28R-08	TCGA-F7-A622-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1188c0e9-1f41-4b7e-8bfb-b6ad5a724466	46f9d879-7a87-4b25-adcb-bc10db818781	g.chr1:983661delG	ENST00000379370.2	+	23	4071	c.4021delG	c.(4021-4023)ggfs	p.G1342fs		NM_198576.3	NP_940978.2	O00468	AGRIN_HUMAN	agrin	1342	EGF-like 1.				axon guidance|clustering of voltage-gated sodium channels|muscarinic acetylcholine receptor signaling pathway|receptor clustering	basal lamina	laminin binding|structural constituent of cytoskeleton			breast(1)|central_nervous_system(2)|endometrium(8)|kidney(3)|large_intestine(2)|lung(20)|ovary(1)|prostate(1)|skin(3)|urinary_tract(1)	42	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		UCEC - Uterine corpus endometrioid carcinoma (11;0.00462)|Epithelial(90;5.98e-38)|OV - Ovarian serous cystadenocarcinoma(86;5.43e-23)|Colorectal(212;5.97e-05)|COAD - Colon adenocarcinoma(227;0.000201)|Kidney(185;0.0024)|BRCA - Breast invasive adenocarcinoma(365;0.00246)|STAD - Stomach adenocarcinoma(132;0.00645)|KIRC - Kidney renal clear cell carcinoma(229;0.0354)|Lung(427;0.201)		CTGCTTCCACGGGGGGACCTG	0.716													2	4	---	---	---	---					
BCL9	607	broad.mit.edu	37	1	147091501	147091501	+	Frame_Shift_Del	DEL	C	C	-			TCGA-F7-A622-01A-11D-A28R-08	TCGA-F7-A622-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1188c0e9-1f41-4b7e-8bfb-b6ad5a724466	46f9d879-7a87-4b25-adcb-bc10db818781	g.chr1:147091501delC	ENST00000234739.3	+	8	2280	c.1540delC	c.(1540-1542)ccfs	p.P517fs		NM_004326.2	NP_004317.2	O00512	BCL9_HUMAN	B-cell CLL/lymphoma 9	517	Poly-Pro.|Pro-rich.				Wnt receptor signaling pathway	nucleus	protein binding			breast(1)|large_intestine(2)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	7	all_hematologic(923;0.115)					GGTCCGAGGACCCCCCCCTCC	0.582			T	"""IGH@, IGL@"""	B-ALL								9	264	---	---	---	---					
PTGS2	5743	broad.mit.edu	37	1	186646921	186646922	+	Frame_Shift_Ins	INS	-	-	T			TCGA-F7-A622-01A-11D-A28R-08	TCGA-F7-A622-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1188c0e9-1f41-4b7e-8bfb-b6ad5a724466	46f9d879-7a87-4b25-adcb-bc10db818781	g.chr1:186646921_186646922insT	ENST00000367468.5	-	5	634_635	c.498_499insA	c.(496-501)aatgctfs	p.NA166fs	PTGS2_ENST00000490885.2_5'UTR	NM_000963.2	NP_000954.1	P35354	PGH2_HUMAN	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)	166					cellular component movement|cyclooxygenase pathway|hormone biosynthetic process|positive regulation of brown fat cell differentiation|positive regulation of cell migration involved in sprouting angiogenesis|positive regulation of fever generation|positive regulation of fibroblast growth factor production|positive regulation of nitric oxide biosynthetic process|positive regulation of platelet-derived growth factor production|positive regulation of prostaglandin biosynthetic process|positive regulation of transforming growth factor-beta production|positive regulation vascular endothelial growth factor production|regulation of blood pressure|response to oxidative stress|xenobiotic metabolic process	endoplasmic reticulum lumen|endoplasmic reticulum membrane|microsome|neuron projection|nucleus	enzyme binding|heme binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|peroxidase activity|prostaglandin-endoperoxide synthase activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(5)|lung(11)|ovary(1)|skin(2)|upper_aerodigestive_tract(2)	27					Acetaminophen(DB00316)|Aspirin(DB00945)|Balsalazide(DB01014)|Bromfenac(DB00963)|Carprofen(DB00821)|Celecoxib(DB00482)|Ciclopirox(DB01188)|Diclofenac(DB00586)|Diflunisal(DB00861)|Epoprostenol(DB01240)|Etodolac(DB00749)|Etoricoxib(DB01628)|Fenoprofen(DB00573)|Flurbiprofen(DB00712)|gamma-Homolinolenic acid(DB00154)|Ginseng(DB01404)|Ibuprofen(DB01050)|Icosapent(DB00159)|Indomethacin(DB00328)|Ketoprofen(DB01009)|Ketorolac(DB00465)|Lenalidomide(DB00480)|Lumiracoxib(DB01283)|Meclofenamic acid(DB00939)|Mefenamic acid(DB00784)|Meloxicam(DB00814)|Mesalazine(DB00244)|Nabumetone(DB00461)|Naproxen(DB00788)|Oxaprozin(DB00991)|Phenylbutazone(DB00812)|Rofecoxib(DB00533)|Salicyclic acid(DB00936)|Salsalate(DB01399)|Sulindac(DB00605)|Suprofen(DB00870)|Tenoxicam(DB00469)|Thalidomide(DB01041)|Tiaprofenic acid(DB01600)|Tolmetin(DB00500)|Valdecoxib(DB00580)	CTTAGAAGCAATTTTTCCACAA	0.391													8	82	---	---	---	---					
MYT1L	23040	broad.mit.edu	37	2	1947087	1947087	+	Frame_Shift_Del	DEL	C	C	-			TCGA-F7-A622-01A-11D-A28R-08	TCGA-F7-A622-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1188c0e9-1f41-4b7e-8bfb-b6ad5a724466	46f9d879-7a87-4b25-adcb-bc10db818781	g.chr2:1947087delC	ENST00000399161.2	-	9	919	c.172delG	c.(172-174)cgfs	p.A58fs	MYT1L_ENST00000428368.2_Frame_Shift_Del_p.A58fs	NM_015025.2	NP_055840.2	Q9UL68	MYT1L_HUMAN	myelin transcription factor 1-like	58					cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(6)|large_intestine(16)|lung(50)|ovary(5)|prostate(2)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	97	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.037)|all_epithelial(98;0.241)		OV - Ovarian serous cystadenocarcinoma(76;0.169)|all cancers(51;0.244)		CTTTTTTTCGCCAAGGGACAA	0.408													2	4	---	---	---	---					
ANKRD44	91526	broad.mit.edu	37	2	197878278	197878279	+	Frame_Shift_Del	DEL	AA	AA	-			TCGA-F7-A622-01A-11D-A28R-08	TCGA-F7-A622-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1188c0e9-1f41-4b7e-8bfb-b6ad5a724466	46f9d879-7a87-4b25-adcb-bc10db818781	g.chr2:197878278_197878279delAA	ENST00000328737.2	-	18	1881_1882	c.1805_1806delTT	c.(1804-1806)tfs	p.F602fs	ANKRD44_ENST00000282272.8_Frame_Shift_Del_p.F619fs|ANKRD44_ENST00000450567.1_Frame_Shift_Del_p.F602fs|ANKRD44_ENST00000337207.5_Frame_Shift_Del_p.F602fs			Q8N8A2	ANR44_HUMAN	ankyrin repeat domain 44	627							protein binding			NS(1)|endometrium(3)|kidney(2)|large_intestine(9)|lung(20)|ovary(4)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	45			OV - Ovarian serous cystadenocarcinoma(117;0.246)			TGTCTTTCACAAAGATGGATGC	0.470													50	143	---	---	---	---					
CPOX	1371	broad.mit.edu	37	3	98243852	98243853	+	RNA	DEL	TT	TT	-	rs148870367		TCGA-F7-A622-01A-11D-A28R-08	TCGA-F7-A622-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1188c0e9-1f41-4b7e-8bfb-b6ad5a724466	46f9d879-7a87-4b25-adcb-bc10db818781	g.chr3:98243852_98243853delTT	ENST00000502999.1	+	0	264																											GAGAACAGTCTTTTTTTTTTTT	0.347													4	2	---	---	---	---					
FBXW7	55294	broad.mit.edu	37	4	153249517	153249526	+	Frame_Shift_Del	DEL	TATGTCCCAC	TATGTCCCAC	-			TCGA-F7-A622-01A-11D-A28R-08	TCGA-F7-A622-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1188c0e9-1f41-4b7e-8bfb-b6ad5a724466	46f9d879-7a87-4b25-adcb-bc10db818781	g.chr4:153249517_153249526delTATGTCCCAC	ENST00000281708.4	-	9	2481_2490	c.1252_1261delGTGGGACATA	c.(1252-1263)cafs	p.VGHT418fs	FBXW7_ENST00000296555.5_Frame_Shift_Del_p.VGHT300fs|FBXW7_ENST00000603548.1_Frame_Shift_Del_p.VGHT418fs|FBXW7_ENST00000603841.1_Frame_Shift_Del_p.VGHT418fs|FBXW7_ENST00000263981.5_Frame_Shift_Del_p.VGHT338fs|FBXW7_ENST00000393956.3_Frame_Shift_Del_p.VGHT242fs	NM_033632.3	NP_361014.1	Q969H0	FBXW7_HUMAN	F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase	418					interspecies interaction between organisms|lipid homeostasis|negative regulation of DNA endoreduplication|negative regulation of hepatocyte proliferation|negative regulation of Notch signaling pathway|negative regulation of triglyceride biosynthetic process|positive regulation of epidermal growth factor receptor activity|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein stabilization|protein ubiquitination|regulation of lipid storage|regulation of protein localization|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|sister chromatid cohesion|vasculature development	nucleolus|nucleoplasm|SCF ubiquitin ligase complex	protein binding	p.H420Y(1)|p.?(1)		NS(1)|biliary_tract(8)|bone(1)|breast(5)|central_nervous_system(6)|cervix(2)|endometrium(36)|haematopoietic_and_lymphoid_tissue(159)|kidney(6)|large_intestine(155)|lung(31)|ovary(10)|pancreas(3)|prostate(2)|skin(6)|stomach(16)|upper_aerodigestive_tract(9)|urinary_tract(6)	462	all_hematologic(180;0.093)	Acute lymphoblastic leukemia(8;0.000629)|all_hematologic(8;0.067)				ACTCCACCTGTATGTCCCACTAATGTTCTC	0.357			"""Mis, N, D, F"""		"""colorectal, endometrial, T-ALL"""								73	55	---	---	---	---					
FAT1	2195	broad.mit.edu	37	4	187630162	187630163	+	Frame_Shift_Ins	INS	-	-	A			TCGA-F7-A622-01A-11D-A28R-08	TCGA-F7-A622-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1188c0e9-1f41-4b7e-8bfb-b6ad5a724466	46f9d879-7a87-4b25-adcb-bc10db818781	g.chr4:187630162_187630163insA	ENST00000441802.2	-	2	1028_1029	c.819_820insT	c.(817-822)tacaatfs	p.N274fs		NM_005245.3	NP_005236.2	Q14517	FAT1_HUMAN	FAT atypical cadherin 1	274					actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(38)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(33)|lung(88)|ovary(13)|pancreas(2)|prostate(16)|skin(2)|upper_aerodigestive_tract(11)|urinary_tract(4)	228						GTCACAATTGCATATGCTGGGT	0.505										HNSCC(5;0.00058)			200	129	---	---	---	---					
CEP164P1	100289237	broad.mit.edu	37	10	45551207	45551207	+	RNA	DEL	T	T	-			TCGA-F7-A622-01A-11D-A28R-08	TCGA-F7-A622-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1188c0e9-1f41-4b7e-8bfb-b6ad5a724466	46f9d879-7a87-4b25-adcb-bc10db818781	g.chr10:45551207delT	ENST00000456938.2	-	0	411																											ATACCTTCAATCAAAAACCTT	0.358													2	4	---	---	---	---					
SPTBN2	6712	broad.mit.edu	37	11	66483306	66483306	+	Frame_Shift_Del	DEL	T	T	-			TCGA-F7-A622-01A-11D-A28R-08	TCGA-F7-A622-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1188c0e9-1f41-4b7e-8bfb-b6ad5a724466	46f9d879-7a87-4b25-adcb-bc10db818781	g.chr11:66483306delT	ENST00000533211.1	-	4	635	c.304delA	c.(304-306)tafs	p.I102fs	SPTBN2_ENST00000529997.1_Frame_Shift_Del_p.I102fs|SPTBN2_ENST00000309996.2_Frame_Shift_Del_p.I102fs			O15020	SPTN2_HUMAN	spectrin, beta, non-erythrocytic 2	102	Actin-binding.|CH 1.				actin filament capping|axon guidance|cell death|vesicle-mediated transport	cytosol|spectrin	actin binding|structural constituent of cytoskeleton			autonomic_ganglia(1)|breast(1)|central_nervous_system(4)|cervix(1)|endometrium(10)|kidney(5)|large_intestine(15)|liver(1)|lung(22)|ovary(2)|pancreas(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	74						CTCACCAGTATCTCTCCCGAG	0.637													8	38	---	---	---	---					
PLEKHG6	55200	broad.mit.edu	37	12	6436582	6436583	+	In_Frame_Ins	INS	-	-	GCC			TCGA-F7-A622-01A-11D-A28R-08	TCGA-F7-A622-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1188c0e9-1f41-4b7e-8bfb-b6ad5a724466	46f9d879-7a87-4b25-adcb-bc10db818781	g.chr12:6436582_6436583insGCC	ENST00000449001.2	+	14	2231_2232	c.1737_1738insGCC	c.(1735-1740)agccct>agGCCccct	p.579_579S>RP	PLEKHG6_ENST00000396988.3_In_Frame_Ins_p.611_611S>RP|PLEKHG6_ENST00000011684.7_In_Frame_Ins_p.611_611S>RP|PLEKHG6_ENST00000304581.8_In_Frame_Ins_p.141_141S>RP	NM_001144857.1	NP_001138329.1	Q3KR16	PKHG6_HUMAN	pleckstrin homology domain containing, family G (with RhoGef domain) member 6	611					regulation of Rho protein signal transduction	cleavage furrow|cytoplasm|spindle pole	GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|kidney(3)|large_intestine(4)|lung(6)|ovary(1)|prostate(2)|skin(4)	23						TACGCCAAAGAGCCCTTCGGCG	0.658													79	178	---	---	---	---					
KMT2D	8085	broad.mit.edu	37	12	49445506	49445521	+	Frame_Shift_Del	DEL	ATAGGCGCGATACCTC	ATAGGCGCGATACCTC	-			TCGA-F7-A622-01A-11D-A28R-08	TCGA-F7-A622-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1188c0e9-1f41-4b7e-8bfb-b6ad5a724466	46f9d879-7a87-4b25-adcb-bc10db818781	g.chr12:49445506_49445521delATAGGCGCGATACCTC	ENST00000301067.7	-	10	1944_1959	c.1945_1960delGAGGTATCGCGCCTAT	c.(1945-1962)ccfs	p.EVSRLS649fs		NM_003482.3	NP_003473.3			lysine (K)-specific methyltransferase 2D																		GGCAGGGGGGATAGGCGCGATACCTCAGGTGGGGGG	0.639													11	72	---	---	---	---					
CXXC1	30827	broad.mit.edu	37	18	47809071	47809071	+	Frame_Shift_Del	DEL	A	A	-			TCGA-F7-A622-01A-11D-A28R-08	TCGA-F7-A622-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1188c0e9-1f41-4b7e-8bfb-b6ad5a724466	46f9d879-7a87-4b25-adcb-bc10db818781	g.chr18:47809071delA	ENST00000285106.6	-	15	2577	c.1863delT	c.(1861-1863)aafs	p.N621fs	CXXC1_ENST00000412036.2_Frame_Shift_Del_p.N625fs|CXXC1_ENST00000589940.1_Frame_Shift_Del_p.M609fs	NM_001101654.1|NM_014593.3	NP_001095124.1|NP_055408.2	Q9P0U4	CXXC1_HUMAN	CXXC finger protein 1	621					histone H3-K4 methylation|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear speck|Set1C/COMPASS complex	protein binding|unmethylated CpG binding|zinc ion binding			autonomic_ganglia(1)|endometrium(5)|kidney(1)|large_intestine(3)|lung(8)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	24						CTGTGCGCACATTGCGCTCCT	0.647													30	63	---	---	---	---					
KIAA1683	80726	broad.mit.edu	37	19	18368905	18368909	+	Frame_Shift_Del	DEL	GTCCG	GTCCG	-	rs61746499	byFrequency	TCGA-F7-A622-01A-11D-A28R-08	TCGA-F7-A622-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1188c0e9-1f41-4b7e-8bfb-b6ad5a724466	46f9d879-7a87-4b25-adcb-bc10db818781	g.chr19:18368905_18368909delGTCCG	ENST00000392413.3	-	4	3400_3404	c.3185_3189delCGGAC	c.(3184-3189)gfs	p.AD1062fs	KIAA1683_ENST00000600328.2_Frame_Shift_Del_p.AD875fs|KIAA1683_ENST00000600359.2_Frame_Shift_Del_p.AD829fs	NM_001145304.1|NM_001145305.1|NM_025249.3	NP_001138776.1|NP_001138777.1|NP_079525.1	Q9H0B3	K1683_HUMAN	KIAA1683	1076						mitochondrion				breast(1)|endometrium(7)|kidney(2)|large_intestine(7)|lung(11)|ovary(2)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	37						CCACACCAGCGTCCGCGGGGCCCTG	0.639													17	81	---	---	---	---					
CEACAM20	125931	broad.mit.edu	37	19	45015427	45015427	+	RNA	DEL	T	T	-			TCGA-F7-A622-01A-11D-A28R-08	TCGA-F7-A622-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1188c0e9-1f41-4b7e-8bfb-b6ad5a724466	46f9d879-7a87-4b25-adcb-bc10db818781	g.chr19:45015427delT	ENST00000454753.1	-	0	1891							Q6UY09	CEA20_HUMAN	carcinoembryonic antigen-related cell adhesion molecule 20							integral to membrane				central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(8)|prostate(1)	15		Prostate(69;0.0352)				CCCAGCCTCCTTTTCACCCCA	0.552													2	4	---	---	---	---					
ZNF880	400713	broad.mit.edu	37	19	52877717	52877717	+	Frame_Shift_Del	DEL	T	T	-	rs77187934		TCGA-F7-A622-01A-11D-A28R-08	TCGA-F7-A622-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1188c0e9-1f41-4b7e-8bfb-b6ad5a724466	46f9d879-7a87-4b25-adcb-bc10db818781	g.chr19:52877717delT	ENST00000597976.1	+	3	325	c.305delT	c.(304-306)atfs	p.I102fs	ZNF880_ENST00000600321.1_Intron|ZNF880_ENST00000344085.5_Intron|ZNF880_ENST00000422689.2_Intron|ZNF880_ENST00000424032.2_Intron			Q6PDB4	ZN880_HUMAN	zinc finger protein 880	0					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(2)|skin(1)	10						GGCCCCATAAttttttttttt	0.473													5	10	---	---	---	---