Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
USP7	7874	broad.mit.edu	37	16	8998351	8998351	+	Missense_Mutation	SNP	T	T	C			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr16:8998351T>C	ENST00000344836.4	-	15	1843	c.1645A>G	c.(1645-1647)Agg>Ggg	p.R549G	USP7_ENST00000381886.4_Missense_Mutation_p.R533G|USP7_ENST00000535863.1_Missense_Mutation_p.R450G	NM_003470.2	NP_003461.2	Q93009	UBP7_HUMAN	ubiquitin specific peptidase 7 (herpes virus-associated)	549					interspecies interaction between organisms|multicellular organismal development|protein deubiquitination|regulation of sequence-specific DNA binding transcription factor activity|ubiquitin-dependent protein catabolic process	cytoplasm|PML body	cysteine-type endopeptidase activity|p53 binding|protein C-terminus binding|transcription factor binding|ubiquitin protein ligase binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(13)|lung(20)|ovary(3)|skin(2)|upper_aerodigestive_tract(1)	48						GCCTCGATCCTTTTCTCTTCT	0.557000													5	70					0	0	1	0	0
ZFP42	132625	broad.mit.edu	37	4	188924394	188924394	+	Missense_Mutation	SNP	G	G	C			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr4:188924394G>C	ENST00000326866.4	+	4	841	c.433G>C	c.(433-435)Gag>Cag	p.E145Q	ZFP42_ENST00000509524.1_Missense_Mutation_p.E145Q	NM_174900.3	NP_777560.2	Q96MM3	ZFP42_HUMAN	ZFP42 zinc finger protein	145					female gonad development|male gonad development|meiosis	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(15)|ovary(1)|skin(2)|stomach(1)	27		all_cancers(14;6.2e-52)|all_epithelial(14;7.36e-37)|all_lung(41;2.29e-15)|Lung NSC(41;6.7e-15)|Breast(6;1.53e-05)|Melanoma(20;3.01e-05)|Hepatocellular(41;0.00335)|all_hematologic(60;0.014)|Renal(120;0.0183)|Prostate(90;0.0421)|Colorectal(36;0.227)		OV - Ovarian serous cystadenocarcinoma(60;1.54e-11)|BRCA - Breast invasive adenocarcinoma(30;4.21e-06)|GBM - Glioblastoma multiforme(59;8.93e-05)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.157)		TGAGTATTCTGAGTACATGAC	0.443000													17	181					0	0	1	0	0
FAM71B	153745	broad.mit.edu	37	5	156592712	156592712	+	Silent	SNP	G	G	C			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr5:156592712G>C	ENST00000302938.4	-	1	563	c.468C>G	c.(466-468)ccC>ccG	p.P156P		NM_130899.2	NP_570969.2	Q8TC56	FA71B_HUMAN	family with sequence similarity 71, member B	156						nucleus				NS(3)|breast(1)|central_nervous_system(3)|cervix(1)|endometrium(2)|kidney(5)|large_intestine(10)|lung(32)|ovary(4)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	68	Renal(175;0.00212)	Medulloblastoma(196;0.0523)|all_neural(177;0.21)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			TGTCAGAAGAGGGACACAACT	0.468000													9	88					0	0	1	0	0
FRMD5	84978	broad.mit.edu	37	15	44166378	44166378	+	Missense_Mutation	SNP	T	T	G			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr15:44166378T>G	ENST00000417257.1	-	14	1594	c.1418A>C	c.(1417-1419)gAg>gCg	p.E473A	FRMD5_ENST00000402883.1_Missense_Mutation_p.E473A|FRMD5_ENST00000484674.1_Missense_Mutation_p.E379A	NM_032892.3	NP_116281.2	Q7Z6J6	FRMD5_HUMAN	FERM domain containing 5	473						cytoplasm|cytoskeleton|extrinsic to membrane|integral to membrane	cytoskeletal protein binding			breast(2)|cervix(1)|endometrium(2)|large_intestine(1)|lung(5)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	14		all_cancers(109;2.29e-15)|all_epithelial(112;9.98e-13)|Lung NSC(122;4.89e-08)|all_lung(180;5.08e-07)|Melanoma(134;0.0275)		all cancers(107;8.63e-20)|GBM - Glioblastoma multiforme(94;3.63e-06)		CCCAAGGGCCTCCACCTCTGT	0.577000													18	67					0	0	1	0	0
DNAJC3	5611	broad.mit.edu	37	13	96375576	96375576	+	Missense_Mutation	SNP	C	C	T			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr13:96375576C>T	ENST00000602402.1	+	3	391	c.274C>T	c.(274-276)Cct>Tct	p.P92S	DNAJC3_ENST00000376795.6_Missense_Mutation_p.P92S	NM_006260.4	NP_006251.1	Q13217	DNJC3_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 3	92					protein folding|response to unfolded protein|response to virus		heat shock protein binding|protein kinase inhibitor activity|unfolded protein binding			NS(1)|breast(1)|kidney(4)|large_intestine(1)|lung(4)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	15	all_neural(89;0.0878)|Breast(111;0.148)|Medulloblastoma(90;0.163)		BRCA - Breast invasive adenocarcinoma(86;0.126)			AGCTGCACTTCCTGATTTAAC	0.348000													11	138					0	0	1	0	0
SIPA1L2	57568	broad.mit.edu	37	1	232649841	232649841	+	Silent	SNP	C	C	T			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr1:232649841C>T	ENST00000366630.1	-	2	1603	c.1245G>A	c.(1243-1245)gaG>gaA	p.E415E	SIPA1L2_ENST00000262861.4_Silent_p.E415E			Q9P2F8	SI1L2_HUMAN	signal-induced proliferation-associated 1 like 2	415					regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			NS(1)|breast(5)|central_nervous_system(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(13)|lung(49)|ovary(2)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	103		all_cancers(173;0.00605)|Prostate(94;0.128)|all_epithelial(177;0.186)				CCCCTCCAGTCTCATTTCTAA	0.522000													14	252					0	0	1	0	0
SOGA2	23255	broad.mit.edu	37	18	8784583	8784583	+	Silent	SNP	G	G	A	rs115241522	by1000genomes	TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr18:8784583G>A	ENST00000359865.3	+	6	1615	c.1473G>A	c.(1471-1473)ccG>ccA	p.P491P	SOGA2_ENST00000517570.1_Silent_p.P491P|SOGA2_ENST00000306329.11_Silent_p.P851P|SOGA2_ENST00000306285.7_5'UTR|SOGA2_ENST00000400050.3_Silent_p.P491P	NM_015210.3	NP_056025.2	Q9Y4B5	CC165_HUMAN	SOGA family member 2	842																	CGCCCTTACCGGGGCCTGGCC	0.662000													5	119					0	0	1	0	0
SEC23A	10484	broad.mit.edu	37	14	39536445	39536445	+	Missense_Mutation	SNP	G	G	C			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr14:39536445G>C	ENST00000537403.1	-	6	1755	c.553C>G	c.(553-555)Caa>Gaa	p.Q185E	SEC23A_ENST00000545328.2_Missense_Mutation_p.Q358E|SEC23A_ENST00000536508.1_Missense_Mutation_p.Q261E|SEC23A_ENST00000307712.6_Missense_Mutation_p.Q387E			Q15436	SC23A_HUMAN	Sec23 homolog A (S. cerevisiae)	387					COPII vesicle coating|intracellular protein transport|post-translational protein modification|protein N-linked glycosylation via asparagine	COPII vesicle coat|cytosol|Golgi membrane|smooth endoplasmic reticulum membrane	protein binding|zinc ion binding			kidney(2)|large_intestine(3)|liver(1)|lung(11)|ovary(4)|pancreas(1)|upper_aerodigestive_tract(1)	23	Hepatocellular(127;0.213)		Lung(238;0.00047)|LUAD - Lung adenocarcinoma(48;0.000565)	GBM - Glioblastoma multiforme(112;0.0151)		AAGACTCTTTGAAAAGTTTGT	0.358000													62	108					0	0	1	0	0
MUC4	4585	broad.mit.edu	37	3	195505859	195505859	+	Missense_Mutation	SNP	T	T	C			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr3:195505859T>C	ENST00000463781.3	-	2	13051	c.12592A>G	c.(12592-12594)Act>Gct	p.T4198A	MUC4_ENST00000349607.4_Intron|MUC4_ENST00000346145.4_Intron|MUC4_ENST00000475231.1_Missense_Mutation_p.T4198A	NM_018406.6	NP_060876.5	Q99102	MUC4_HUMAN	mucin 4, cell surface associated	961					cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity	p.T4198A(2)		NS(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(5)|lung(23)|ovary(3)|prostate(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	51	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		GCTGAGGAAGTGTCGGTGACA	0.602000													4	7					0	0	1	0	0
SPTLC3	55304	broad.mit.edu	37	20	13055073	13055073	+	Missense_Mutation	SNP	G	G	A			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr20:13055073G>A	ENST00000399002.2	+	4	809	c.535G>A	c.(535-537)Gag>Aag	p.E179K	SPTLC3_ENST00000378194.4_Missense_Mutation_p.E179K	NM_018327.2	NP_060797.2	Q9NUV7	SPTC3_HUMAN	serine palmitoyltransferase, long chain base subunit 3	179					sphingoid biosynthetic process	integral to membrane|serine C-palmitoyltransferase complex	pyridoxal phosphate binding|serine C-palmitoyltransferase activity|transferase activity, transferring nitrogenous groups			breast(1)|endometrium(1)|large_intestine(7)|lung(14)|skin(1)|urinary_tract(1)	25					Pyridoxal Phosphate(DB00114)	CAAGTATGATGAGTCTATGAG	0.433000													10	74					0	0	1	0	0
RTBDN	83546	broad.mit.edu	37	19	12936651	12936651	+	Missense_Mutation	SNP	A	A	G			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr19:12936651A>G	ENST00000322912.5	-	7	972	c.655T>C	c.(655-657)Tcc>Ccc	p.S219P	RTBDN_ENST00000592204.1_Missense_Mutation_p.S197P|RTBDN_ENST00000393233.2_3'UTR|CTD-2265O21.3_ENST00000588469.1_RNA|RTBDN_ENST00000589272.1_3'UTR|RTBDN_ENST00000458671.2_Missense_Mutation_p.S187P	NM_031429.2	NP_113617.1	Q9BSG5	RTBDN_HUMAN	retbindin	187						extracellular region				kidney(1)|large_intestine(5)|liver(1)|lung(4)|prostate(1)	12						GGTACCGCGGAGATGGAGATG	0.692000											OREG0025275	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	3	35					0	0	1	0	0
SHANK2	22941	broad.mit.edu	37	11	70319147	70319147	+	Missense_Mutation	SNP	C	C	T			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr11:70319147C>T	ENST00000338508.4	-	33	5379	c.5380G>A	c.(5380-5382)Gat>Aat	p.D1794N	SHANK2_ENST00000409161.1_Missense_Mutation_p.D1197N|SHANK2_ENST00000449833.2_Missense_Mutation_p.D1198N|SHANK2_ENST00000423696.2_Missense_Mutation_p.D1414N			Q9UPX8	SHAN2_HUMAN	SH3 and multiple ankyrin repeat domains 2	1414					intracellular signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	GKAP/Homer scaffold activity|ionotropic glutamate receptor binding|SH3 domain binding			NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(30)|ovary(3)|pancreas(2)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	62			LUSC - Lung squamous cell carcinoma(11;4.72e-09)|STAD - Stomach adenocarcinoma(18;0.071)			TCCAGCCAATCGGCCACATCT	0.483000													7	494					0	0	1	0	0
OR4A47	403253	broad.mit.edu	37	11	48510886	48510886	+	Missense_Mutation	SNP	C	C	A			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr11:48510886C>A	ENST00000446524.1	+	1	618	c.542C>A	c.(541-543)cCc>cAc	p.P181H		NM_001005512.2	NP_001005512.2	Q6IF82	O4A47_HUMAN	olfactory receptor, family 4, subfamily A, member 47	181					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.P181L(1)		NS(1)|breast(2)|endometrium(1)|kidney(1)|large_intestine(2)|lung(18)|ovary(1)|skin(1)|urinary_tract(2)	29						GACATGTATCCCTTATTGAAA	0.443000													12	291					1.05317e-09	1.17327e-09	1	1	0
ADSSL1	122622	broad.mit.edu	37	14	105208336	105208336	+	Missense_Mutation	SNP	C	C	G			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr14:105208336C>G	ENST00000332972.5	+	9	1233	c.1074C>G	c.(1072-1074)atC>atG	p.I358M	ADSSL1_ENST00000330877.2_Missense_Mutation_p.I315M	NM_199165.1	NP_954634.1	Q8N142	PURA1_HUMAN	adenylosuccinate synthase like 1	315					AMP biosynthetic process|immune system process|purine base metabolic process	cytosol	adenylosuccinate synthase activity|GTP binding|magnesium ion binding|phosphate binding			central_nervous_system(1)|cervix(1)|kidney(1)|lung(5)|ovary(2)|prostate(1)	11		all_cancers(154;0.0896)|Melanoma(154;0.155)|all_epithelial(191;0.172)	all cancers(16;0.00153)|OV - Ovarian serous cystadenocarcinoma(23;0.0148)|Epithelial(46;0.0396)|GBM - Glioblastoma multiforme(11;0.116)	Epithelial(152;0.18)	L-Aspartic Acid(DB00128)	CCGAGCAGATCAACGTGAGTC	0.687000													4	131					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179496028	179496028	+	Splice_Site	SNP	C	C	A			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr2:179496028C>A	ENST00000589042.1	-	237	43972		c.e237-1		TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000591111.1_Splice_Site|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000589830.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Splice_Site|TTN-AS1_ENST00000589487.1_RNA|TTN_ENST00000359218.5_Splice_Site|TTN_ENST00000342992.6_Splice_Site|TTN_ENST00000342175.6_Splice_Site|TTN-AS1_ENST00000589907.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin								ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GGGTCTCCCTCTGCAAGTAAA	0.353000													6	38					0.00116845	0.00120644	1	1	0
USP8	9101	broad.mit.edu	37	15	50790834	50790834	+	Missense_Mutation	SNP	C	C	G			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr15:50790834C>G	ENST00000433963.1	+	20	3580	c.3080C>G	c.(3079-3081)tCt>tGt	p.S1027C	USP8_ENST00000396444.3_Missense_Mutation_p.S1027C|RP11-562A8.4_ENST00000560380.1_RNA|USP8_ENST00000425032.3_Missense_Mutation_p.S921C|USP8_ENST00000307179.4_Missense_Mutation_p.S1027C	NM_001128611.1	NP_001122083.1	P40818	UBP8_HUMAN	ubiquitin specific peptidase 8	1027					cell cycle|cell proliferation|endosome organization|protein K48-linked deubiquitination|protein K63-linked deubiquitination|ubiquitin-dependent protein catabolic process	cytosol|early endosome|extrinsic to plasma membrane|nucleus	cysteine-type endopeptidase activity|SH3 domain binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(5)|lung(16)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	35				all cancers(107;0.000225)|GBM - Glioblastoma multiforme(94;0.000771)		TTACAGACATCTGTGGACTTC	0.353000													13	152					0	0	1	0	0
WHAMMP3	339005	broad.mit.edu	37	15	23205098	23205098	+	RNA	SNP	G	G	A	rs146035894	by1000genomes	TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr15:23205098G>A	ENST00000400153.2	-	0	756					NR_003521.1																						CTGGAAGAACGTGGTTGCCAC	0.373000													3	24					0	0	1	0	0
LAMC3	10319	broad.mit.edu	37	9	133957545	133957545	+	Nonsense_Mutation	SNP	G	G	T			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr9:133957545G>T	ENST00000361069.4	+	24	4160	c.4027G>T	c.(4027-4029)Gaa>Taa	p.E1343*	LAMC3_ENST00000480883.1_Intron	NM_006059.3	NP_006050.3	Q9Y6N6	LAMC3_HUMAN	laminin, gamma 3	1343	Domain II and I.				cell adhesion	basement membrane|membrane	structural molecule activity			endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(12)|lung(31)|ovary(3)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(2)|urinary_tract(3)	69	all_hematologic(7;0.0028)	Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;5.06e-05)|Epithelial(140;0.000551)		GGCTGATCTGGAAGGTACGTG	0.622000													6	17					8.12818e-05	8.63832e-05	1	1	0
ACTL9	284382	broad.mit.edu	37	19	8808866	8808866	+	Missense_Mutation	SNP	C	C	G			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr19:8808866C>G	ENST00000324436.3	-	1	306	c.186G>C	c.(184-186)aaG>aaC	p.K62N		NM_178525.3	NP_848620.2	Q8TC94	ACTL9_HUMAN	actin-like 9	62						cytoplasm|cytoskeleton				NS(2)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(8)|lung(15)|pancreas(1)|prostate(3)|skin(1)|urinary_tract(1)	36						CAAAACCTACCTTACAGGTGC	0.652000													19	44					0	0	1	0	0
LDB1	8861	broad.mit.edu	37	10	103871212	103871212	+	Missense_Mutation	SNP	G	G	A			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr10:103871212G>A	ENST00000425280.1	-	2	449	c.107C>T	c.(106-108)aCc>aTc	p.T36I	LDB1_ENST00000361198.5_5'UTR|LDB1_ENST00000490751.1_5'UTR	NM_001113407.1	NP_001106878.1	Q86U70	LDB1_HUMAN	LIM domain binding 1	36					histone H3-K4 acetylation|negative regulation of erythrocyte differentiation|negative regulation of transcription, DNA-dependent|positive regulation of hemoglobin biosynthetic process|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription elongation, DNA-dependent|transcription, DNA-dependent|transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery	nuclear chromatin|protein complex	LIM domain binding|protein homodimerization activity|transcription corepressor activity			breast(1)|central_nervous_system(4)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(5)|prostate(1)|skin(1)	21		Colorectal(252;0.122)		Epithelial(162;1.11e-07)|all cancers(201;1.82e-06)		ATCCAGCATGGTGCCGGGATG	0.577000													20	61					0	0	1	0	0
SEC16B	89866	broad.mit.edu	37	1	177936837	177936837	+	Missense_Mutation	SNP	G	G	T			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr1:177936837G>T	ENST00000308284.6	-	2	369	c.280C>A	c.(280-282)Cgc>Agc	p.R94S	RP4-798P15.3_ENST00000354921.2_5'UTR|RP4-798P15.3_ENST00000528461.1_Missense_Mutation_p.R94S|SEC16B_ENST00000464631.1_Missense_Mutation_p.R94S	NM_033127.2	NP_149118.2	Q96JE7	SC16B_HUMAN	SEC16 homolog B (S. cerevisiae)	94	Required for endoplasmic reticulum localization.|Tyr-rich.				protein transport|vesicle-mediated transport	endoplasmic reticulum membrane|Golgi membrane				central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(7)|lung(14)|ovary(3)|skin(1)|stomach(1)	35						AACTGATTGCGATAACCACCT	0.483000													15	58					6.72482e-11	7.52469e-11	1	1	0
SLC8A1	6546	broad.mit.edu	37	2	40655965	40655965	+	Missense_Mutation	SNP	C	C	G			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr2:40655965C>G	ENST00000406785.1	-	2	1645	c.1456G>C	c.(1456-1458)Gag>Cag	p.E486Q	SLC8A1_ENST00000542756.1_Missense_Mutation_p.E486Q|SLC8A1_ENST00000542024.1_Missense_Mutation_p.E486Q|SLC8A1_ENST00000408028.2_Missense_Mutation_p.E486Q|SLC8A1_ENST00000405901.3_Missense_Mutation_p.E486Q|SLC8A1_ENST00000405269.1_Missense_Mutation_p.E486Q|SLC8A1_ENST00000403092.1_Missense_Mutation_p.E486Q|SLC8A1_ENST00000402441.1_Missense_Mutation_p.E486Q|SLC8A1_ENST00000332839.4_Missense_Mutation_p.E486Q|SLC8A1_ENST00000406391.2_Missense_Mutation_p.E486Q			P32418	NAC1_HUMAN	solute carrier family 8 (sodium/calcium exchanger), member 1	486	Calx-beta 1.				cell communication|muscle contraction|platelet activation	integral to plasma membrane	calcium:sodium antiporter activity|calmodulin binding|heat shock protein binding			NS(1)|central_nervous_system(1)|endometrium(7)|kidney(5)|large_intestine(14)|liver(1)|lung(57)|ovary(2)|pancreas(1)|skin(7)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(2)	100					Alpha-Linolenic Acid(DB00132)|Icosapent(DB00159)	TCATCCTCCTCAAAGATATCA	0.408000													18	80					0	0	1	0	0
ZSCAN29	146050	broad.mit.edu	37	15	43656252	43656252	+	Silent	SNP	G	G	A			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr15:43656252G>A	ENST00000396976.2	-	4	1685	c.1551C>T	c.(1549-1551)acC>acT	p.T517T	ZSCAN29_ENST00000562072.1_Intron|ZSCAN29_ENST00000568898.1_Intron|ZSCAN29_ENST00000396972.1_Intron	NM_152455.3	NP_689668.3	Q8IWY8	ZSC29_HUMAN	zinc finger and SCAN domain containing 29	517					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			cervix(1)|endometrium(2)|kidney(3)|large_intestine(9)|lung(7)|skin(2)	24		all_cancers(109;2.12e-14)|all_epithelial(112;1.99e-12)|Lung NSC(122;2.46e-08)|all_lung(180;2.75e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;8.97e-07)		CAGCCTCACTGGTCCCCTGGA	0.557000													23	91					0	0	1	0	0
DCLRE1A	9937	broad.mit.edu	37	10	115610123	115610123	+	Missense_Mutation	SNP	C	C	G			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr10:115610123C>G	ENST00000361384.2	-	2	1658	c.741G>C	c.(739-741)aaG>aaC	p.K247N	DCLRE1A_ENST00000369305.1_Missense_Mutation_p.K247N	NM_014881.3	NP_055696.3	Q6PJP8	DCR1A_HUMAN	DNA cross-link repair 1A	247					cell division|mitosis	nucleus	hydrolase activity			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(2)|kidney(2)|large_intestine(10)|lung(8)|prostate(1)|skin(2)|urinary_tract(1)	31				Epithelial(162;0.0157)|all cancers(201;0.0171)		GAGTAGAAATCTTTTCACTGG	0.378000								Other identified genes with known or suspected DNA repair function					22	95					0	0	1	0	0
ZBTB34	403341	broad.mit.edu	37	9	129641824	129641824	+	Missense_Mutation	SNP	C	C	A			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr9:129641824C>A	ENST00000319119.4	+	2	231	c.146C>A	c.(145-147)gCc>gAc	p.A49D	ZBTB34_ENST00000373452.2_Missense_Mutation_p.A45D	NM_001099270.1	NP_001092740.1	Q8NCN2	ZBT34_HUMAN	zinc finger and BTB domain containing 34	45	BTB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|large_intestine(2)|lung(2)|ovary(1)|prostate(3)|upper_aerodigestive_tract(1)	12						CCATTCCGAGCCCACAAAGCA	0.502000													71	115					3.58576e-35	4.15883e-35	1	1	0
SNRPA	6626	broad.mit.edu	37	19	41257370	41257370	+	Missense_Mutation	SNP	G	G	C			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr19:41257370G>C	ENST00000243563.3	+	1	607	c.57G>C	c.(55-57)gaG>gaC	p.E19D	SNRPA_ENST00000599570.1_3'UTR	NM_004596.4	NP_004587.1	P09012	SNRPA_HUMAN	small nuclear ribonucleoprotein polypeptide A	19	RRM 1.					nucleoplasm|spliceosomal complex	nucleotide binding|protein binding|RNA binding			central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(3)|ovary(1)|prostate(1)|skin(2)	10			LUSC - Lung squamous cell carcinoma(20;0.000219)|Lung(22;0.000959)			ACCTCAATGAGAAGATCAAGA	0.527000													8	196					0	0	1	0	0
AIM1	202	broad.mit.edu	37	6	106973153	106973153	+	Missense_Mutation	SNP	A	A	G			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr6:106973153A>G	ENST00000369066.3	+	4	3567	c.3080A>G	c.(3079-3081)tAt>tGt	p.Y1027C		NM_001624.2	NP_001615.1	Q9Y4K1	AIM1_HUMAN	absent in melanoma 1	1027	Beta/gamma crystallin 'Greek key' 1.						sugar binding			breast(8)|central_nervous_system(1)|cervix(2)|endometrium(6)|kidney(7)|large_intestine(13)|lung(20)|ovary(5)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	69	Breast(9;0.0138)|all_epithelial(6;0.169)	all_cancers(87;4.67e-25)|all_epithelial(87;5.46e-21)|Acute lymphoblastic leukemia(125;2.15e-07)|all_hematologic(75;5.28e-06)|Colorectal(196;3.46e-05)|all_lung(197;5.94e-05)|Lung NSC(302;7.26e-05)|Ovarian(999;0.00473)	Epithelial(6;0.00114)|all cancers(7;0.00726)|BRCA - Breast invasive adenocarcinoma(8;0.0114)|OV - Ovarian serous cystadenocarcinoma(5;0.0305)	all cancers(137;1.73e-50)|Epithelial(106;2.42e-48)|OV - Ovarian serous cystadenocarcinoma(136;1.51e-27)|BRCA - Breast invasive adenocarcinoma(108;0.00104)|GBM - Glioblastoma multiforme(226;0.00858)		GTAGTGATATATAGTGAACCC	0.388000													82	231					0	0	1	0	0
PIK3R3	8503	broad.mit.edu	37	1	46512294	46512294	+	Nonsense_Mutation	SNP	C	C	T			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr1:46512294C>T	ENST00000262741.5	-	8	1634	c.945G>A	c.(943-945)tgG>tgA	p.W315*	PIK3R3_ENST00000488808.1_5'UTR|PIK3R3_ENST00000354242.4_Nonsense_Mutation_p.W256*|PIK3R3_ENST00000420542.1_Nonsense_Mutation_p.W315*|PIK3R3_ENST00000423209.1_Nonsense_Mutation_p.W256*|PIK3R3_ENST00000340332.6_Nonsense_Mutation_p.W220*|PIK3R3_ENST00000540385.1_Nonsense_Mutation_p.W361*|PIK3R3_ENST00000372006.1_Nonsense_Mutation_p.W315*	NM_003629.3	NP_003620.3	Q92569	P55G_HUMAN	phosphoinositide-3-kinase, regulatory subunit 3 (gamma)	315					insulin receptor signaling pathway|platelet activation|T cell costimulation		1-phosphatidylinositol-3-kinase activity|protein binding			endometrium(1)|large_intestine(5)|lung(6)|prostate(2)	14	Acute lymphoblastic leukemia(166;0.155)					TGTGATTGAGCCATCTGCCAG	0.448000													4	107					0	0	1	0	0
SYNE2	23224	broad.mit.edu	37	14	64595250	64595250	+	Missense_Mutation	SNP	G	G	C			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr14:64595250G>C	ENST00000357395.3	+	75	14297	c.3153G>C	c.(3151-3153)caG>caC	p.Q1051H	ESR2_ENST00000542956.1_Intron|SYNE2_ENST00000344113.4_Missense_Mutation_p.Q4666H|SYNE2_ENST00000555002.1_Missense_Mutation_p.Q1300H|SYNE2_ENST00000554584.1_Intron|SYNE2_ENST00000394768.2_Missense_Mutation_p.Q1051H|SYNE2_ENST00000358025.3_Missense_Mutation_p.Q4666H			Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	4666					centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding	p.Q4666H(1)		NS(5)|breast(17)|central_nervous_system(3)|cervix(8)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(21)|large_intestine(34)|lung(75)|ovary(10)|pancreas(2)|prostate(8)|skin(8)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(4)	224				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		TCAGTGGGCAGAGTGTTGCTG	0.358000													33	123					0	0	1	0	0
GTF3C1	2975	broad.mit.edu	37	16	27480820	27480820	+	Missense_Mutation	SNP	C	C	G			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr16:27480820C>G	ENST00000356183.4	-	32	4881	c.4866G>C	c.(4864-4866)ttG>ttC	p.L1622F	GTF3C1_ENST00000561623.1_Missense_Mutation_p.L1622F	NM_001520.3	NP_001511.2	Q12789	TF3C1_HUMAN	general transcription factor IIIC, polypeptide 1, alpha 220kDa	1622	Asp/Glu-rich (acidic).					transcription factor TFIIIC complex	DNA binding|protein binding			breast(2)|central_nervous_system(4)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(14)|liver(3)|lung(28)|ovary(2)|pancreas(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)	80						CACCTTCGTCCAAGTCATCCT	0.592000													20	55					0	0	1	0	0
BTK	695	broad.mit.edu	37	X	100630177	100630177	+	Silent	SNP	C	C	T			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chrX:100630177C>T	ENST00000308731.7	-	2	259	c.96G>A	c.(94-96)ttG>ttA	p.L32L	BTK_ENST00000464567.1_5'UTR|BTK_ENST00000372880.1_Silent_p.L32L	NM_000061.2	NP_000052.1	Q06187	BTK_HUMAN	Bruton agammaglobulinemia tyrosine kinase	32	PH.				calcium-mediated signaling|induction of apoptosis by extracellular signals|mesoderm development	cytosol|membrane raft|nucleus|plasma membrane	ATP binding|identical protein binding|metal ion binding|non-membrane spanning protein tyrosine kinase activity|phosphatidylinositol-3,4,5-trisphosphate binding			breast(4)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(10)|lung(25)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	50						TGTGCACGGTCAAGAGAAACA	0.433000									Agammaglobulinemia, X-linked				13	116					0	0	1	0	0
LIPE	3991	broad.mit.edu	37	19	42931220	42931220	+	Missense_Mutation	SNP	C	C	G			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr19:42931220C>G	ENST00000244289.4	-	1	358	c.82G>C	c.(82-84)Ggg>Cgg	p.G28R	LIPE-AS1_ENST00000593740.2_RNA|LIPE-AS1_ENST00000597203.1_RNA|LIPE-AS1_ENST00000594688.1_RNA|LIPE-AS1_ENST00000457234.2_RNA|LIPE-AS1_ENST00000594624.2_RNA	NM_005357.2	NP_005348.2	Q05469	LIPS_HUMAN	lipase, hormone-sensitive	28					cholesterol metabolic process|protein phosphorylation|triglyceride catabolic process	caveola|cytosol	hormone-sensitive lipase activity|protein binding			breast(2)|endometrium(4)|kidney(7)|large_intestine(6)|lung(8)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	32		Prostate(69;0.00682)				TTTTCTGGCCCAGGCTCTAGC	0.537000													28	88					0	0	1	0	0
LAMC3	10319	broad.mit.edu	37	9	133957544	133957544	+	Silent	SNP	G	G	T			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr9:133957544G>T	ENST00000361069.4	+	24	4159	c.4026G>T	c.(4024-4026)ctG>ctT	p.L1342L	LAMC3_ENST00000480883.1_Intron	NM_006059.3	NP_006050.3	Q9Y6N6	LAMC3_HUMAN	laminin, gamma 3	1342	Domain II and I.				cell adhesion	basement membrane|membrane	structural molecule activity			endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(12)|lung(31)|ovary(3)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(2)|urinary_tract(3)	69	all_hematologic(7;0.0028)	Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;5.06e-05)|Epithelial(140;0.000551)		TGGCTGATCTGGAAGGTACGT	0.617000													7	17					0.000157383	0.000165187	1	1	0
PRICKLE2	166336	broad.mit.edu	37	3	64085012	64085012	+	Missense_Mutation	SNP	C	C	G			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr3:64085012C>G	ENST00000295902.6	-	8	2835	c.2250G>C	c.(2248-2250)agG>agC	p.R750S	PRICKLE2_ENST00000564377.1_Missense_Mutation_p.R806S|RP11-129B22.1_ENST00000482609.1_RNA|PRICKLE2-AS1_ENST00000476308.1_RNA	NM_198859.3	NP_942559.1	Q7Z3G6	PRIC2_HUMAN	prickle homolog 2 (Drosophila)	750						cytoplasm|nuclear membrane	zinc ion binding			breast(2)|endometrium(1)|large_intestine(9)|liver(1)|lung(10)|ovary(4)|prostate(2)|skin(2)|stomach(1)	32		Lung NSC(201;0.136)		BRCA - Breast invasive adenocarcinoma(55;0.000971)|KIRC - Kidney renal clear cell carcinoma(15;0.00443)|Kidney(15;0.00497)		CCGACACAGTCCTAGGGCACT	0.597000													12	31					0	0	1	0	0
VWF	7450	broad.mit.edu	37	12	6058331	6058331	+	Missense_Mutation	SNP	G	G	C			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr12:6058331G>C	ENST00000261405.5	-	52	8546	c.8292C>G	c.(8290-8292)atC>atG	p.I2764M		NM_000552.3	NP_000543.2	P04275	VWF_HUMAN	von Willebrand factor	2764	CTCK.				blood coagulation, intrinsic pathway|cell-substrate adhesion|platelet activation|platelet degranulation|protein homooligomerization	endoplasmic reticulum|platelet alpha granule lumen|proteinaceous extracellular matrix|Weibel-Palade body	chaperone binding|collagen binding|glycoprotein binding|immunoglobulin binding|integrin binding|protease binding|protein homodimerization activity|protein N-terminus binding			NS(1)|breast(6)|central_nervous_system(5)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(25)|lung(41)|ovary(7)|pancreas(2)|prostate(6)|skin(15)|stomach(1)|upper_aerodigestive_tract(5)	129					Antihemophilic Factor(DB00025)	GCACATCGTTGATGTCAATGG	0.567000													27	47					0	0	1	0	0
RASA3	22821	broad.mit.edu	37	13	114780794	114780794	+	Silent	SNP	C	C	T			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr13:114780794C>T	ENST00000334062.7	-	14	1417	c.1296G>A	c.(1294-1296)caG>caA	p.Q432Q	RASA3_ENST00000389544.4_Silent_p.Q400Q	NM_007368.2	NP_031394.2	Q14644	RASA3_HUMAN	RAS p21 protein activator 3	432	Ras-GAP.				intracellular signal transduction|negative regulation of Ras protein signal transduction	cytoplasm|intrinsic to internal side of plasma membrane	calcium-release channel activity|metal ion binding|Ras GTPase activator activity			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(8)|lung(20)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	47	Lung NSC(43;0.00814)|all_neural(89;0.0337)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.016)|all_epithelial(44;0.00577)|all_lung(25;0.0173)|Lung NSC(25;0.0634)|Breast(118;0.188)	BRCA - Breast invasive adenocarcinoma(86;0.128)			GGTCCACATACTGCCGTAGGT	0.667000													12	68					0	0	1	0	0
PPP1R3A	5506	broad.mit.edu	37	7	113518332	113518332	+	Missense_Mutation	SNP	T	T	A			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr7:113518332T>A	ENST00000284601.3	-	4	2883	c.2815A>T	c.(2815-2817)Act>Tct	p.T939S		NM_002711.3	NP_002702.2	Q16821	PPR3A_HUMAN	protein phosphatase 1, regulatory subunit 3A	939					glycogen metabolic process	integral to membrane				NS(2)|breast(8)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(14)|liver(1)|lung(43)|ovary(10)|pancreas(7)|prostate(3)|skin(15)|stomach(1)|upper_aerodigestive_tract(2)	121						GCCATGGTAGTAACTGCATTC	0.383000													12	167					0	0	1	0	0
SLC4A5	57835	broad.mit.edu	37	2	74452001	74452001	+	Missense_Mutation	SNP	C	C	T			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr2:74452001C>T	ENST00000394019.2	-	28	3609	c.3212G>A	c.(3211-3213)aGa>aAa	p.R1071K	RP11-287D1.3_ENST00000451608.2_3'UTR|SLC4A5_ENST00000377632.1_Missense_Mutation_p.R990K|SLC4A5_ENST00000357822.5_Missense_Mutation_p.R1087K|SLC4A5_ENST00000359484.4_Missense_Mutation_p.R969K|SLC4A5_ENST00000358683.4_Missense_Mutation_p.R969K|SLC4A5_ENST00000483195.1_5'UTR|SLC4A5_ENST00000346834.4_Missense_Mutation_p.R990K|SLC4A5_ENST00000423644.1_3'UTR|SLC4A5_ENST00000377634.4_Missense_Mutation_p.R1087K	NM_133478.2	NP_597812.1	Q9BY07	S4A5_HUMAN	solute carrier family 4 (sodium bicarbonate cotransporter), member 5	1087						apical plasma membrane|integral to membrane	inorganic anion exchanger activity|sodium:bicarbonate symporter activity			breast(5)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(12)|lung(13)|ovary(5)|pancreas(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	48						CCCTTTTTTTCTCTTCCTCTT	0.517000													32	133					0	0	1	0	0
EPG5	57724	broad.mit.edu	37	18	43514833	43514833	+	Silent	SNP	C	C	T			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr18:43514833C>T	ENST00000282041.5	-	11	2233	c.2199G>A	c.(2197-2199)gaG>gaA	p.E733E		NM_020964.2	NP_066015.2	Q9HCE0	EPG5_HUMAN	ectopic P-granules autophagy protein 5 homolog (C. elegans)	733					autophagy					NS(1)|breast(9)|central_nervous_system(3)|cervix(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(22)|lung(35)|ovary(2)|pancreas(1)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	95						GCTGCAGGTTCTCGCTCTCCA	0.592000													15	36					0	0	1	0	0
NGFR	4804	broad.mit.edu	37	17	47583779	47583779	+	Silent	SNP	C	C	T			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr17:47583779C>T	ENST00000172229.3	+	3	452	c.327C>T	c.(325-327)tgC>tgT	p.C109C	NGFR_ENST00000504201.1_Silent_p.C15C|RP5-1029K10.2_ENST00000514506.1_RNA	NM_002507.3	NP_002498.1	P08138	TNR16_HUMAN	nerve growth factor receptor	109					anti-apoptosis|apoptosis|induction of apoptosis by extracellular signals|membrane protein intracellular domain proteolysis|negative regulation of axonogenesis|negative regulation of cell cycle|nerve growth factor receptor signaling pathway|positive regulation of axonogenesis	cell surface|cytosol|endosome|extracellular region|integral to plasma membrane|nucleoplasm				central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|liver(1)|lung(7)|ovary(1)	17	all_cancers(4;1.45e-13)|Breast(4;6.34e-28)|all_epithelial(4;4.95e-17)					TGTGCCGCTGCGCCTACGGCT	0.706000													9	27					0	0	1	0	0
THAP5	168451	broad.mit.edu	37	7	108204694	108204694	+	Missense_Mutation	SNP	C	C	T			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr7:108204694C>T	ENST00000415914.3	-	3	1282	c.1129G>A	c.(1129-1131)Gaa>Aaa	p.E377K	THAP5_ENST00000313516.5_Missense_Mutation_p.E335K	NM_001130475.1	NP_001123947.1	Q7Z6K1	THAP5_HUMAN	THAP domain containing 5	377					cell cycle|negative regulation of cell cycle	nucleus	DNA binding|metal ion binding|protease binding			central_nervous_system(1)|kidney(1)|large_intestine(3)|lung(2)|skin(1)	8						ACGTTTTCTTCAGATAGCCAG	0.318000													47	132					0	0	1	0	0
CAPZA2	830	broad.mit.edu	37	7	116550339	116550339	+	Nonsense_Mutation	SNP	C	C	G			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr7:116550339C>G	ENST00000458284.2	+	6	532	c.479C>G	c.(478-480)tCa>tGa	p.S160*	CAPZA2_ENST00000361183.2_Missense_Mutation_p.Q187E			P47755	CAZA2_HUMAN	capping protein (actin filament) muscle Z-line, alpha 2	166					actin cytoskeleton organization|actin filament capping|blood coagulation|cellular component movement|innate immune response|protein complex assembly	cytosol|extracellular region|F-actin capping protein complex	actin binding			endometrium(2)|kidney(3)|large_intestine(4)|lung(2)|skin(1)|upper_aerodigestive_tract(1)	13	all_cancers(3;8.53e-08)|all_epithelial(6;7.79e-08)|Lung NSC(10;0.00108)|all_lung(10;0.00125)		GBM - Glioblastoma multiforme(2;5.01e-06)|STAD - Stomach adenocarcinoma(10;0.000512)|all cancers(2;0.00326)			TTCAACCACTCAAGTGGTTGG	0.328000													3	55					0	0	1	0	0
PEX5L	51555	broad.mit.edu	37	3	179592147	179592147	+	Missense_Mutation	SNP	C	C	A	rs142589999		TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr3:179592147C>A	ENST00000467460.1	-	7	1024	c.694G>T	c.(694-696)Gct>Tct	p.A232S	PEX5L_ENST00000472994.1_Missense_Mutation_p.A173S|PEX5L_ENST00000468741.1_Missense_Mutation_p.A40S|PEX5L_ENST00000467440.2_5'UTR|PEX5L_ENST00000465751.1_Missense_Mutation_p.A208S|PEX5L_ENST00000464614.1_Missense_Mutation_p.A124S|PEX5L_ENST00000392649.3_Missense_Mutation_p.A124S|PEX5L_ENST00000263962.8_Missense_Mutation_p.A230S|PEX5L_ENST00000485199.1_Missense_Mutation_p.A197S|PEX5L_ENST00000476138.1_Missense_Mutation_p.A189S	NM_001256751.1|NM_016559.2	NP_001243680.1|NP_057643.1	Q8IYB4	PEX5R_HUMAN	peroxisomal biogenesis factor 5-like	232					protein import into peroxisome matrix|regulation of cAMP-mediated signaling	cytosol|peroxisomal membrane	peroxisome matrix targeting signal-1 binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(23)|ovary(3)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	49	all_cancers(143;3.94e-14)|Ovarian(172;0.0338)|Breast(254;0.183)		OV - Ovarian serous cystadenocarcinoma(80;1.75e-26)|GBM - Glioblastoma multiforme(14;0.000518)			AATTCTGAAGCCGACTCAGAG	0.393000													33	115					4.34311e-12	4.88119e-12	1	1	0
PBRM1	55193	broad.mit.edu	37	3	52643393	52643393	+	Missense_Mutation	SNP	G	G	A			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr3:52643393G>A	ENST00000356770.4	-	15	2409	c.2407C>T	c.(2407-2409)Cgt>Tgt	p.R803C	PBRM1_ENST00000410007.1_Missense_Mutation_p.R835C|PBRM1_ENST00000409057.1_Missense_Mutation_p.R835C|PBRM1_ENST00000409767.1_Missense_Mutation_p.R850C|PBRM1_ENST00000296302.7_Missense_Mutation_p.R835C|PBRM1_ENST00000394830.3_Missense_Mutation_p.R835C|PBRM1_ENST00000409114.3_Missense_Mutation_p.R850C|PBRM1_ENST00000337303.4_Missense_Mutation_p.R835C			Q86U86	PB1_HUMAN	polybromo 1	835	Bromo 6.				chromatin remodeling|mitosis|negative regulation of cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear chromosome	chromatin binding|DNA binding|protein binding			breast(5)|endometrium(5)|kidney(301)|liver(1)|lung(22)|pancreas(1)	335				BRCA - Breast invasive adenocarcinoma(193;1.8e-05)|Kidney(197;0.00105)|KIRC - Kidney renal clear cell carcinoma(197;0.00122)|OV - Ovarian serous cystadenocarcinoma(275;0.0613)		TCAAGCCGACGGTAGCGATTA	0.368000			"""Mis, N, F, S, D, O"""		"""clear cell renal carcinoma, breast"""								4	84					0	0	1	0	0
CNTRL	11064	broad.mit.edu	37	9	123917162	123917162	+	Missense_Mutation	SNP	G	G	A			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr9:123917162G>A	ENST00000373855.1	+	27	4596	c.4336G>A	c.(4336-4338)Gag>Aag	p.E1446K	CNTRL_ENST00000373847.1_Missense_Mutation_p.E894K|CNTRL_ENST00000373845.2_3'UTR|CNTRL_ENST00000373850.1_Missense_Mutation_p.E894K|CNTRL_ENST00000238341.5_Missense_Mutation_p.E1446K			Q7Z7A1	CNTRL_HUMAN	centriolin	1446					cell division|G2/M transition of mitotic cell cycle	centrosome|cytosol	protein binding	p.E1446K(1)		haematopoietic_and_lymphoid_tissue(2)|large_intestine(9)|lung(2)|ovary(4)|skin(3)	20						GGCAGAGGCTGAGAGTGAACT	0.463000													7	133					0	0	1	0	0
C9orf171	389799	broad.mit.edu	37	9	135374895	135374895	+	Silent	SNP	C	C	G			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr9:135374895C>G	ENST00000343036.2	+	4	588	c.540C>G	c.(538-540)ctC>ctG	p.L180L	C9orf171_ENST00000393215.3_Silent_p.L144L|C9orf171_ENST00000393216.2_Silent_p.L144L	NM_207417.1	NP_997300.1	Q6ZQR2	CI171_HUMAN	chromosome 9 open reading frame 171	180										large_intestine(7)|lung(9)|ovary(4)|prostate(3)	23						ACCGTCAGCTCAATGACATCC	0.602000													35	131					0	0	1	0	0
PPIL4	85313	broad.mit.edu	37	6	149838518	149838518	+	Translation_Start_Site	SNP	G	G	T			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr6:149838518G>T	ENST00000340881.2	-	0	482				PPIL4_ENST00000253329.2_Missense_Mutation_p.L351M			Q8WUA2	PPIL4_HUMAN	peptidylprolyl isomerase (cyclophilin)-like 4						protein folding	nucleus	nucleotide binding|peptidyl-prolyl cis-trans isomerase activity|RNA binding			endometrium(2)|kidney(4)|large_intestine(1)|lung(4)|prostate(1)|urinary_tract(1)	13		Ovarian(120;0.0164)		OV - Ovarian serous cystadenocarcinoma(155;1.11e-11)|GBM - Glioblastoma multiforme(68;0.0885)		TTATCTTTCAGAACCAAATTA	0.343000													4	100					0.217242	0.217242	1	1	0
ZNF208	7757	broad.mit.edu	37	19	22154848	22154848	+	Silent	SNP	A	A	T			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr19:22154848A>T	ENST00000397126.4	-	4	3136	c.2988T>A	c.(2986-2988)acT>acA	p.T996T	ZNF208_ENST00000599916.1_Intron|ZNF208_ENST00000601773.1_Intron	NM_007153.3	NP_009084.2			zinc finger protein 208											breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(18)|liver(1)|lung(71)|ovary(6)|prostate(3)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	113		all_lung(12;0.0961)|Lung NSC(12;0.103)				GTTTCTCTCCAGTATGAATTA	0.353000													5	68					0	0	1	0	0
DNAH6	1768	broad.mit.edu	37	2	84806759	84806759	+	Missense_Mutation	SNP	G	G	A			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr2:84806759G>A	ENST00000389394.3	+	14	2322	c.2185G>A	c.(2185-2187)Gaa>Aaa	p.E729K	DNAH6_ENST00000398278.2_Missense_Mutation_p.E729K|DNAH6_ENST00000237449.6_Missense_Mutation_p.E729K	NM_001370.1	NP_001361.1	Q9C0G6	DYH6_HUMAN	dynein, axonemal, heavy chain 6	729	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(2)|breast(9)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(3)|lung(14)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	57						TACTACCACAGAATATGTTCA	0.348000													7	137					0	0	1	0	0
ALS2CR11	151254	broad.mit.edu	37	2	202469364	202469364	+	Silent	SNP	C	C	T			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr2:202469364C>T	ENST00000439140.1	-	2	332	c.288G>A	c.(286-288)gaG>gaA	p.E96E	ALS2CR11_ENST00000450242.1_Silent_p.E96E|ALS2CR11_ENST00000286195.3_Silent_p.E96E|ALS2CR11_ENST00000439802.1_Silent_p.E96E	NM_001168221.1	NP_001161693.1	Q53TS8	AL2SA_HUMAN	amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 11	96										NS(1)|breast(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(10)|lung(11)|ovary(1)|skin(5)|urinary_tract(3)	33						AATTTGGCGTCTCCTGTGTTA	0.333000													11	160					0	0	1	0	0
PRSS36	146547	broad.mit.edu	37	16	31155036	31155036	+	Silent	SNP	G	G	C			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr16:31155036G>C	ENST00000268281.4	-	7	901	c.843C>G	c.(841-843)acC>acG	p.T281T	PRSS36_ENST00000418068.2_Silent_p.T281T|PRSS36_ENST00000569305.1_Silent_p.T281T	NM_001258290.1|NM_173502.4	NP_001245219.1|NP_775773.2	Q5K4E3	POLS2_HUMAN	protease, serine, 36	281	Peptidase S1 1.				proteolysis	cytoplasm|proteinaceous extracellular matrix	serine-type endopeptidase activity			kidney(2)|large_intestine(4)|lung(8)|ovary(3)	17						ATGCCTCATAGGTAGCCACAG	0.612000													19	51					0	0	1	0	0
GMIP	51291	broad.mit.edu	37	19	19749029	19749029	+	Missense_Mutation	SNP	G	G	A			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr19:19749029G>A	ENST00000203556.4	-	9	865	c.728C>T	c.(727-729)tCg>tTg	p.S243L	GMIP_ENST00000445806.2_Missense_Mutation_p.S243L|GMIP_ENST00000587238.1_Missense_Mutation_p.S243L	NM_016573.2	NP_057657.2	Q9P107	GMIP_HUMAN	GEM interacting protein	243					negative regulation of Rho GTPase activity|small GTPase mediated signal transduction	cytosol	metal ion binding|protein binding|Rho GTPase activator activity			breast(1)|endometrium(6)|kidney(1)|large_intestine(2)|lung(9)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	24						AGGTCCCGGCGAGGCCTGGGG	0.751000													3	16					0	0	1	0	0
HSPH1	10808	broad.mit.edu	37	13	31722148	31722148	+	Silent	SNP	T	T	C			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr13:31722148T>C	ENST00000320027.5	-	10	1670	c.1326A>G	c.(1324-1326)ctA>ctG	p.L442L	HSPH1_ENST00000429785.2_Silent_p.L261L|HSPH1_ENST00000445273.2_Silent_p.L444L|HSPH1_ENST00000380405.4_Silent_p.L442L|HSPH1_ENST00000380406.5_Silent_p.L401L	NM_006644.2	NP_006635.2	Q92598	HS105_HUMAN	heat shock 105kDa/110kDa protein 1	442					positive regulation of MHC class I biosynthetic process|positive regulation of NK T cell activation|response to unfolded protein	cytoplasm|extracellular region	ATP binding			breast(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(4)|lung(7)|ovary(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	27		Lung SC(185;0.0257)		all cancers(112;0.00385)|Epithelial(112;0.0328)|OV - Ovarian serous cystadenocarcinoma(117;0.0375)|GBM - Glioblastoma multiforme(144;0.125)		AGAAAGCTTCTAGCTCAAAAG	0.388000													63	207					0	0	1	0	0
DHX15	1665	broad.mit.edu	37	4	24557974	24557974	+	Missense_Mutation	SNP	T	T	C			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr4:24557974T>C	ENST00000336812.4	-	4	917	c.761A>G	c.(760-762)tAt>tGt	p.Y254C		NM_001358.2	NP_001349.2	O43143	DHX15_HUMAN	DEAH (Asp-Glu-Ala-His) box helicase 15	254	Helicase ATP-binding.				mRNA processing	U12-type spliceosomal complex	ATP binding|ATP-dependent helicase activity|nucleic acid binding|RNA helicase activity			breast(4)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(5)|liver(1)|lung(6)|ovary(1)|upper_aerodigestive_tract(1)	30		Breast(46;0.0503)				TATTACACCATAACGCTCCAG	0.403000													24	61					0	0	1	0	0
KCTD8	386617	broad.mit.edu	37	4	44449605	44449605	+	Missense_Mutation	SNP	G	G	T			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr4:44449605G>T	ENST00000360029.3	-	1	1219	c.936C>A	c.(934-936)agC>agA	p.S312R		NM_198353.2	NP_938167.1	Q6ZWB6	KCTD8_HUMAN	potassium channel tetramerization domain containing 8	312						cell junction|postsynaptic membrane|presynaptic membrane|voltage-gated potassium channel complex	voltage-gated potassium channel activity			central_nervous_system(3)|endometrium(4)|kidney(2)|large_intestine(5)|lung(19)|ovary(1)|prostate(3)|upper_aerodigestive_tract(4)	41						CGGTGTAGCTGCTCCAGATCT	0.637000										HNSCC(17;0.042)			8	26					0.000157383	0.000165187	1	1	0
NIPBL	25836	broad.mit.edu	37	5	37052593	37052593	+	Nonsense_Mutation	SNP	C	C	G			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr5:37052593C>G	ENST00000282516.8	+	42	7687	c.7188C>G	c.(7186-7188)taC>taG	p.Y2396*	NIPBL_ENST00000448238.2_Nonsense_Mutation_p.Y2396*	NM_015384.4|NM_133433.3	NP_056199.2|NP_597677.2	Q6KC79	NIPBL_HUMAN	Nipped-B homolog (Drosophila)	2396					brain development|cellular protein localization|cellular response to X-ray|cognition|developmental growth|ear morphogenesis|embryonic arm morphogenesis|embryonic digestive tract morphogenesis|external genitalia morphogenesis|eye morphogenesis|face morphogenesis|gall bladder development|maintenance of mitotic sister chromatid cohesion|metanephros development|negative regulation of transcription from RNA polymerase II promoter|outflow tract morphogenesis|positive regulation of histone deacetylation|regulation of developmental growth|regulation of embryonic development|regulation of hair cycle|response to DNA damage stimulus|sensory perception of sound|uterus morphogenesis	SMC loading complex	chromo shadow domain binding|histone deacetylase binding|protein C-terminus binding|protein N-terminus binding			autonomic_ganglia(1)|breast(4)|endometrium(9)|kidney(22)|large_intestine(21)|liver(1)|lung(47)|ovary(7)|pancreas(1)|prostate(1)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(4)	128	all_lung(31;0.000447)|Hepatocellular(1;0.108)		Epithelial(62;0.072)|COAD - Colon adenocarcinoma(61;0.14)|all cancers(62;0.191)|Colorectal(62;0.202)			CACACCTTTACTCCATGATCC	0.423000													45	220					0	0	1	0	0
LMTK2	22853	broad.mit.edu	37	7	97821553	97821553	+	Silent	SNP	C	C	G			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr7:97821553C>G	ENST00000297293.5	+	11	2069	c.1776C>G	c.(1774-1776)ctC>ctG	p.L592L		NM_014916.3	NP_055731.2	Q8IWU2	LMTK2_HUMAN	lemur tyrosine kinase 2	592					early endosome to late endosome transport|endocytic recycling|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|protein autophosphorylation|receptor recycling|transferrin transport	early endosome|Golgi apparatus|integral to membrane|perinuclear region of cytoplasm|recycling endosome	ATP binding|myosin VI binding|protein phosphatase inhibitor activity|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(2)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(13)|lung(25)|ovary(1)|pancreas(2)|skin(2)|stomach(3)	59	all_cancers(62;3.23e-09)|all_epithelial(64;7.65e-10)|Lung NSC(181;0.00902)|all_lung(186;0.0104)|Esophageal squamous(72;0.0125)					TCACGGCGCTCAGGAGCGTTG	0.527000													11	82					0	0	1	0	0
DPPA4	55211	broad.mit.edu	37	3	109049641	109049641	+	Missense_Mutation	SNP	T	T	G			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr3:109049641T>G	ENST00000335658.6	-	5	463	c.409A>C	c.(409-411)Aaa>Caa	p.K137Q	DPPA4_ENST00000478791.1_5'UTR	NM_018189.3	NP_060659.3	Q7L190	DPPA4_HUMAN	developmental pluripotency associated 4	137						nucleus	protein binding			central_nervous_system(1)|endometrium(2)|large_intestine(1)|lung(17)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	25						TTGGCCTCTTTTGCTGTGCTA	0.363000													71	82					0	0	1	0	0
SEC14L3	266629	broad.mit.edu	37	22	30857319	30857319	+	Silent	SNP	G	G	C			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr22:30857319G>C	ENST00000403066.1	-	12	1165	c.882C>G	c.(880-882)ctC>ctG	p.L294L	SEC14L3_ENST00000415957.2_Silent_p.L294L|SEC14L3_ENST00000540910.1_Silent_p.L276L|SEC14L3_ENST00000402286.1_Silent_p.L276L|SEC14L3_ENST00000401751.1_Silent_p.L294L|SEC14L3_ENST00000539629.1_Silent_p.L294L|SEC14L3_ENST00000215812.4_Silent_p.L353L			Q9UDX4	S14L3_HUMAN	SEC14-like 3 (S. cerevisiae)	353	GOLD.					integral to membrane|intracellular	lipid binding|transporter activity			NS(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(3)|ovary(3)|pancreas(1)|skin(2)|urinary_tract(1)	19					Vitamin E(DB00163)	CTGAGCAGGTGAGGTTCCCAT	0.597000													12	117					0	0	1	0	0
OR4D6	219983	broad.mit.edu	37	11	59224503	59224503	+	Missense_Mutation	SNP	G	G	C			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr11:59224503G>C	ENST00000300127.2	+	1	93	c.70G>C	c.(70-72)Gag>Cag	p.E24Q		NM_001004708.1	NP_001004708.1	Q8NGJ1	OR4D6_HUMAN	olfactory receptor, family 4, subfamily D, member 6	24					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(3)|lung(20)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	34						CCGAGAGCTGGAGTTTTTCTT	0.473000													5	186					0	0	1	0	0
RFX4	5992	broad.mit.edu	37	12	107113760	107113760	+	Silent	SNP	C	C	G			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr12:107113760C>G	ENST00000392842.1	+	12	1575	c.1161C>G	c.(1159-1161)ctC>ctG	p.L387L	RP11-482D24.3_ENST00000552415.1_RNA|RFX4_ENST00000357881.4_Silent_p.L396L|RP11-144F15.1_ENST00000551505.1_Intron|RFX4_ENST00000229387.5_Silent_p.L293L	NM_213594.2	NP_998759.1	Q33E94	RFX4_HUMAN	regulatory factor X, 4 (influences HLA class II expression)	387	Necessary for dimerization.				transcription, DNA-dependent	nucleus	DNA binding			NS(2)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(20)|pancreas(1)|upper_aerodigestive_tract(1)	35						TTGACCATCTCTTGGAGGAGC	0.488000													5	89					0	0	1	0	0
ANKRD20A8P	729171	broad.mit.edu	37	2	95522786	95522786	+	RNA	SNP	T	T	C			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr2:95522786T>C	ENST00000432432.2	-	0	241					NR_040113.1													p.K44K(1)									CGGCGTCGCCTTTGACAGCTG	0.687000													5	98					0	0	1	0	0
ZNF257	113835	broad.mit.edu	37	19	22255710	22255710	+	Missense_Mutation	SNP	G	G	C			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr19:22255710G>C	ENST00000594947.1	+	2	247	c.103G>C	c.(103-105)Gag>Cag	p.E35Q	ZNF257_ENST00000600162.1_Missense_Mutation_p.E35Q	NM_033468.2	NP_258429.2	Q9Y2Q1	ZN257_HUMAN	zinc finger protein 257	35	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			haematopoietic_and_lymphoid_tissue(2)|lung(4)	6		all_lung(12;0.0961)|Lung NSC(12;0.103)				TGTGATGTTAGAGAACTACAG	0.388000													14	221					0	0	1	0	0
ABCA2	20	broad.mit.edu	37	9	139902402	139902402	+	Missense_Mutation	SNP	G	G	C			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr9:139902402G>C	ENST00000265662.5	-	49	7437	c.7290C>G	c.(7288-7290)ttC>ttG	p.F2430L	ABCA2_ENST00000371605.3_Missense_Mutation_p.F2429L|ABCA2_ENST00000341511.6_Missense_Mutation_p.F2430L			Q9BZC7	ABCA2_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 2	2429					cholesterol homeostasis|lipid metabolic process|regulation of intracellular cholesterol transport|regulation of transcription from RNA polymerase II promoter|response to drug|response to steroid hormone stimulus	ATP-binding cassette (ABC) transporter complex|cytoplasmic membrane-bounded vesicle|endosome|integral to membrane|microtubule organizing center	ATP binding|ATPase activity, coupled to transmembrane movement of substances			central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|liver(1)|lung(25)|prostate(2)|skin(1)|stomach(1)|urinary_tract(1)	41	all_cancers(76;0.16)	Myeloproliferative disorder(178;0.0511)	STAD - Stomach adenocarcinoma(284;0.123)	OV - Ovarian serous cystadenocarcinoma(145;2.94e-05)|Epithelial(140;0.00048)		TGTCCGTGTTGAAGGACAGCT	0.662000													3	43					0	0	1	0	0
AGAP11	119385	broad.mit.edu	37	10	88768892	88768892	+	RNA	SNP	C	C	T			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr10:88768892C>T	ENST00000444431.1	+	0	3492				RP11-96C23.5_ENST00000433214.2_RNA|RP11-96C23.14_ENST00000444180.3_RNA			Q8TF27	AGA11_HUMAN	ankyrin repeat and GTPase domain Arf GTPase activating protein 11						regulation of ARF GTPase activity		ARF GTPase activator activity|zinc ion binding										GTATGAGGAGCGGGATGCCTG	0.552000													10	193					0	0	1	0	0
UVRAG	7405	broad.mit.edu	37	11	75851794	75851794	+	Missense_Mutation	SNP	G	G	C			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr11:75851794G>C	ENST00000356136.3	+	15	1678	c.1437G>C	c.(1435-1437)aaG>aaC	p.K479N	UVRAG_ENST00000539288.1_Missense_Mutation_p.K107N|UVRAG_ENST00000532130.1_Missense_Mutation_p.K107N|UVRAG_ENST00000531818.1_Missense_Mutation_p.K107N|UVRAG_ENST00000533454.1_Missense_Mutation_p.K107N|UVRAG_ENST00000538870.1_Missense_Mutation_p.K35N|UVRAG_ENST00000528420.1_Missense_Mutation_p.K378N	NM_003369.3	NP_003360.2	Q9P2Y5	UVRAG_HUMAN	UV radiation resistance associated	479					DNA repair|positive regulation of autophagy	early endosome|late endosome|lysosome	protein binding			central_nervous_system(1)|cervix(3)|endometrium(3)|kidney(1)|large_intestine(2)|lung(15)|skin(5)|urinary_tract(2)	32						CTGTTCCTAAGAGACAAAGCT	0.473000													8	159					0	0	1	0	0
C6	729	broad.mit.edu	37	5	41176755	41176755	+	Missense_Mutation	SNP	T	T	G			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr5:41176755T>G	ENST00000263413.3	-	8	1254	c.990A>C	c.(988-990)aaA>aaC	p.K330N	C6_ENST00000337836.5_Missense_Mutation_p.K330N|C6_ENST00000475349.1_5'UTR	NM_001115131.1	NP_001108603.2	P13671	CO6_HUMAN	complement component 6	330	MACPF.				complement activation, classical pathway|cytolysis|innate immune response	membrane attack complex	protein binding			central_nervous_system(2)|cervix(2)|endometrium(2)|kidney(7)|large_intestine(16)|liver(1)|lung(51)|ovary(3)|prostate(1)|skin(9)|upper_aerodigestive_tract(2)	96		Breast(839;1.07e-05)|Ovarian(839;0.0228)|Lung SC(612;0.0548)|Lung NSC(810;0.128)|all_neural(839;0.157)				GGTGCAGATCTTTAGCTTTCG	0.353000													12	151					0	0	1	0	0
PCSK5	5125	broad.mit.edu	37	9	78686709	78686709	+	Missense_Mutation	SNP	G	G	C			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr9:78686709G>C	ENST00000545128.1	+	7	1327	c.789G>C	c.(787-789)caG>caC	p.Q263H	PCSK5_ENST00000376752.4_Missense_Mutation_p.Q263H|PCSK5_ENST00000376767.3_Missense_Mutation_p.Q263H	NM_001190482.1	NP_001177411.1	Q92824	PCSK5_HUMAN	proprotein convertase subtilisin/kexin type 5	263	Catalytic.				anterior/posterior pattern formation|cell-cell signaling|cytokine biosynthetic process|embryo implantation|embryonic digestive tract development|embryonic skeletal system development|heart development|kidney development|limb morphogenesis|nerve growth factor processing|nerve growth factor receptor signaling pathway|peptide biosynthetic process|renin secretion into blood stream|respiratory tube development|signal peptide processing|viral assembly, maturation, egress, and release	extracellular space|Golgi lumen|stored secretory granule	peptide binding|serine-type endopeptidase activity			NS(1)|breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(7)|liver(2)|lung(25)|ovary(2)|pancreas(1)|prostate(2)|skin(3)	55						TCAACCCCCAGCACGTGCACA	0.542000													11	187					0	0	1	0	0
SLC2A2	6514	broad.mit.edu	37	3	170732436	170732436	+	Missense_Mutation	SNP	C	C	T			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr3:170732436C>T	ENST00000314251.3	-	3	272	c.193G>A	c.(193-195)Gat>Aat	p.D65N	SLC2A2_ENST00000382808.4_Intron	NM_000340.1	NP_000331.1	P11168	GTR2_HUMAN	solute carrier family 2 (facilitated glucose transporter), member 2	65					carbohydrate metabolic process|cellular lipid metabolic process|endocrine pancreas development|energy reserve metabolic process|regulation of insulin secretion	integral to plasma membrane|membrane fraction	D-glucose transmembrane transporter activity			central_nervous_system(1)|endometrium(2)|large_intestine(9)|lung(9)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	24	all_cancers(22;1.41e-19)|all_lung(20;1.59e-15)|Lung NSC(18;7.08e-15)|Ovarian(172;0.00197)|Breast(254;0.122)		LUSC - Lung squamous cell carcinoma(14;1.1e-14)|Lung(28;2.99e-14)			GGCAGTTCATCTGTACTGTTG	0.428000													7	207					0	0	1	0	0
LYZ	4069	broad.mit.edu	37	12	69746053	69746053	+	Missense_Mutation	SNP	C	C	T			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr12:69746053C>T	ENST00000261267.2	+	3	423	c.355C>T	c.(355-357)Cgt>Tgt	p.R119C	LYZ_ENST00000549690.1_Intron	NM_000239.2	NP_000230.1	P61626	LYSC_HUMAN	lysozyme	119					cell wall macromolecule catabolic process|cytolysis|defense response to bacterium|inflammatory response	extracellular space	lysozyme activity|protein binding	p.R119C(1)		endometrium(2)|lung(1)|upper_aerodigestive_tract(1)	4	all_epithelial(5;2.98e-35)|Lung NSC(4;9.93e-33)|all_lung(4;5.66e-31)|Breast(13;2.56e-06)|Esophageal squamous(21;0.187)		Epithelial(6;8.26e-19)|BRCA - Breast invasive adenocarcinoma(5;8.5e-10)|Lung(24;9.68e-05)|LUAD - Lung adenocarcinoma(15;0.00107)|STAD - Stomach adenocarcinoma(21;0.00503)|OV - Ovarian serous cystadenocarcinoma(12;0.00691)|LUSC - Lung squamous cell carcinoma(43;0.24)|Kidney(9;0.241)			GAGGGTTGTCCGTGATCCACA	0.358000													25	91					0	0	1	0	0
OR2M7	391196	broad.mit.edu	37	1	248487820	248487820	+	Silent	SNP	G	G	T			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr1:248487820G>T	ENST00000317965.2	-	1	79	c.51C>A	c.(49-51)atC>atA	p.I17I		NM_001004691.1	NP_001004691.1	Q8NG81	OR2M7_HUMAN	olfactory receptor, family 2, subfamily M, member 7	17					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(6)|large_intestine(3)|lung(29)|skin(3)	42	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			TATGATTGAAGATTCCCAGGA	0.468000													9	230					4.68919e-08	5.1785e-08	1	1	0
TTN	7273	broad.mit.edu	37	2	179584857	179584857	+	Missense_Mutation	SNP	C	C	T			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr2:179584857C>T	ENST00000589042.1	-	81	23736	c.23512G>A	c.(23512-23514)Gag>Aag	p.E7838K	TTN_ENST00000591111.1_Missense_Mutation_p.E7521K|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron|TTN_ENST00000359218.5_Intron|TTN_ENST00000342992.6_Missense_Mutation_p.E6594K|TTN_ENST00000342175.6_Intron	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	7521	Ig-like 60.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTTTCACTCTCTCTGATGACT	0.438000													20	106					0	0	1	0	0
BRWD3	254065	broad.mit.edu	37	X	79990684	79990684	+	Silent	SNP	C	C	T			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chrX:79990684C>T	ENST00000373275.4	-	10	1143	c.927G>A	c.(925-927)gtG>gtA	p.V309V		NM_153252.4	NP_694984.4	Q6RI45	BRWD3_HUMAN	bromodomain and WD repeat domain containing 3	309										breast(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|lung(39)|ovary(4)|prostate(2)|skin(3)	87						CAGTAAATTTCACCGGGCGAT	0.373000													13	42					0	0	1	0	0
SULT1B1	27284	broad.mit.edu	37	4	70596325	70596325	+	Silent	SNP	G	G	T			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr4:70596325G>T	ENST00000310613.2	-	7	969	c.672C>A	c.(670-672)atC>atA	p.I224I		NM_014465.3	NP_055280.2	O43704	ST1B1_HUMAN	sulfotransferase family, cytosolic, 1B, member 1	224					3'-phosphoadenosine 5'-phosphosulfate metabolic process|cellular biogenic amine metabolic process|flavonoid metabolic process|steroid metabolic process|sulfation|thyroid hormone metabolic process|xenobiotic metabolic process	cytosol				breast(1)|cervix(1)|endometrium(2)|large_intestine(4)|lung(14)|prostate(1)|upper_aerodigestive_tract(1)	24						TGTGATGGATGATCCTATCCA	0.373000													15	75					0.00244969	0.00251912	1	1	0
MME	4311	broad.mit.edu	37	3	154855962	154855962	+	Silent	SNP	C	C	T			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr3:154855962C>T	ENST00000460393.1	+	9	912	c.792C>T	c.(790-792)atC>atT	p.I264I	MME_ENST00000462745.1_Silent_p.I264I|MME_ENST00000360490.2_Silent_p.I264I|MME_ENST00000493237.1_Silent_p.I264I|MME_ENST00000492661.1_Silent_p.I264I	NM_000902.3|NM_007287.2	NP_000893.2|NP_009218.2	P08473	NEP_HUMAN	membrane metallo-endopeptidase	264					cell-cell signaling|proteolysis	integral to plasma membrane	metal ion binding|metalloendopeptidase activity|protein binding			central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(31)|ovary(3)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	64		all_neural(597;0.00391)|Myeloproliferative disorder(1037;0.0122)	LUSC - Lung squamous cell carcinoma(72;0.114)|Lung(72;0.135)		Candoxatril(DB00616)	GATTGCCCATCGATGAAAACC	0.338000													19	271					0	0	1	0	0
ALPK2	115701	broad.mit.edu	37	18	56202447	56202447	+	Nonsense_Mutation	SNP	C	C	A			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr18:56202447C>A	ENST00000361673.3	-	5	5185	c.4972G>T	c.(4972-4974)Gga>Tga	p.G1658*		NM_052947.3	NP_443179.3	Q86TB3	ALPK2_HUMAN	alpha-kinase 2	1658							ATP binding|protein serine/threonine kinase activity			NS(1)|central_nervous_system(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(13)|lung(33)|ovary(7)|prostate(1)|skin(10)|upper_aerodigestive_tract(2)	84						TCACGTTCTCCTGAAATAAAT	0.483000													42	91					1.52319e-26	1.75859e-26	1	1	0
SPTAN1	6709	broad.mit.edu	37	9	131348215	131348215	+	Missense_Mutation	SNP	G	G	A			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr9:131348215G>A	ENST00000372739.3	+	19	2859	c.2749G>A	c.(2749-2751)Gac>Aac	p.D917N	SPTAN1_ENST00000372731.4_Missense_Mutation_p.D917N|SPTAN1_ENST00000358161.5_Missense_Mutation_p.D917N	NM_001130438.2	NP_001123910.1	Q13813	SPTA2_HUMAN	spectrin, alpha, non-erythrocytic 1	917					actin filament capping|axon guidance|cellular component disassembly involved in apoptosis	cytosol|intracellular membrane-bounded organelle|membrane fraction|microtubule cytoskeleton|spectrin	actin binding|calcium ion binding|calmodulin binding|structural constituent of cytoskeleton			NS(2)|breast(8)|cervix(2)|endometrium(6)|kidney(4)|large_intestine(21)|liver(1)|lung(25)|ovary(5)|pancreas(1)|prostate(4)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	87						GGGCAGCACTGACTATGGCAA	0.567000													9	118					0	0	1	0	0
IDH2	3418	broad.mit.edu	37	15	90634788	90634788	+	Silent	SNP	C	C	T			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr15:90634788C>T	ENST00000330062.3	-	2	317	c.204G>A	c.(202-204)gaG>gaA	p.E68E	IDH2_ENST00000559482.1_Silent_p.E68E|IDH2_ENST00000540499.2_Silent_p.E16E|IDH2_ENST00000539790.1_Intron	NM_002168.2	NP_002159.2	P48735	IDHP_HUMAN	isocitrate dehydrogenase 2 (NADP+), mitochondrial	68					2-oxoglutarate metabolic process|glyoxylate cycle|isocitrate metabolic process|tricarboxylic acid cycle	mitochondrial matrix	isocitrate dehydrogenase (NADP+) activity|magnesium ion binding|NAD binding			biliary_tract(11)|bone(19)|central_nervous_system(107)|endometrium(1)|haematopoietic_and_lymphoid_tissue(953)|large_intestine(8)|lung(5)|skin(5)	1109	Melanoma(11;0.00551)|Lung NSC(78;0.0196)|all_lung(78;0.04)		BRCA - Breast invasive adenocarcinoma(143;0.0146)|KIRC - Kidney renal clear cell carcinoma(17;0.0286)|Kidney(142;0.0514)|STAD - Stomach adenocarcinoma(125;0.106)			GCACTACCTTCTCCTTGATGA	0.577000			M		GBM								14	96					0	0	1	0	0
IL1R1	3554	broad.mit.edu	37	2	102785108	102785108	+	Missense_Mutation	SNP	A	A	G			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr2:102785108A>G	ENST00000410023.1	+	7	1024	c.706A>G	c.(706-708)Atg>Gtg	p.M236V	IL1R1_ENST00000409589.1_Intron|IL1R1_ENST00000409288.1_Missense_Mutation_p.M236V|IL1R1_ENST00000424272.1_Missense_Mutation_p.M236V|IL1R1_ENST00000409929.1_Missense_Mutation_p.M236V|IL1R1_ENST00000233946.3_Missense_Mutation_p.M236V|IL1R1_ENST00000409329.1_Missense_Mutation_p.M236V			P14778	IL1R1_HUMAN	interleukin 1 receptor, type I	236	Ig-like C2-type 3.				innate immune response	integral to plasma membrane	interleukin-1, Type I, activating receptor activity|platelet-derived growth factor receptor binding			breast(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(4)|prostate(2)|skin(3)	19					Anakinra(DB00026)	TAATGAGACAATGGAAGTAGA	0.368000													23	122					0	0	1	0	0
RAI14	26064	broad.mit.edu	37	5	34811882	34811882	+	Missense_Mutation	SNP	A	A	T	rs140883072		TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr5:34811882A>T	ENST00000265109.3	+	9	855	c.568A>T	c.(568-570)Atg>Ttg	p.M190L	RAI14_ENST00000506376.1_Missense_Mutation_p.M182L|RAI14_ENST00000397449.1_Missense_Mutation_p.M183L|RAI14_ENST00000428746.2_Missense_Mutation_p.M190L|RAI14_ENST00000503673.1_Missense_Mutation_p.M190L|RAI14_ENST00000512629.1_Missense_Mutation_p.M190L|RAI14_ENST00000515799.1_Missense_Mutation_p.M193L	NM_001145522.1|NM_015577.2	NP_001138994.1|NP_056392.2	Q9P0K7	RAI14_HUMAN	retinoic acid induced 14	190						cell cortex|cytoskeleton	protein binding			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(19)|lung(22)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	56	all_lung(31;0.000191)					AACTGCTCTCATGCTGGCCTG	0.373000													29	131					0	0	1	0	0
C22orf31	25770	broad.mit.edu	37	22	29456409	29456409	+	Silent	SNP	G	G	A			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr22:29456409G>A	ENST00000216071.4	-	2	477	c.426C>T	c.(424-426)atC>atT	p.I142I		NM_015370.1	NP_056185.1	O95567	CV031_HUMAN	chromosome 22 open reading frame 31	142										cervix(1)|endometrium(1)|kidney(17)|large_intestine(2)|lung(4)|prostate(1)|skin(1)	27						CTACCTCTCTGATGCCTCCTG	0.527000													7	148					0	0	1	0	0
ANKRD33	341405	broad.mit.edu	37	12	52284807	52284807	+	Silent	SNP	G	G	T			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr12:52284807G>T	ENST00000301190.6	+	5	1304	c.1077G>T	c.(1075-1077)ccG>ccT	p.P359P	ANKRD33_ENST00000340970.4_Intron|ANKRD33_ENST00000547119.1_3'UTR|ANKRD33_ENST00000538991.1_Intron	NM_001130015.1|NM_182608.3	NP_001123487.1|NP_872414.3	Q7Z3H0	ANR33_HUMAN	ankyrin repeat domain 33	235								p.P359P(1)		endometrium(2)|kidney(1)|large_intestine(5)|lung(11)|ovary(1)|skin(1)|urinary_tract(1)	22				BRCA - Breast invasive adenocarcinoma(357;0.0969)		CCCAGTCCCCGCCAGGGAGTC	0.642000													5	26					1.23904e-05	1.33922e-05	1	1	0
GPRC5A	9052	broad.mit.edu	37	12	13061550	13061550	+	Missense_Mutation	SNP	G	G	A			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr12:13061550G>A	ENST00000014914.5	+	2	1257	c.367G>A	c.(367-369)Gtc>Atc	p.V123I	GPRC5A_ENST00000542056.1_Intron	NM_003979.3	NP_003970.1	Q8NFJ5	RAI3_HUMAN	G protein-coupled receptor, family C, group 5, member A	123						cytoplasmic vesicle membrane|Golgi apparatus|integral to plasma membrane	G-protein coupled receptor activity			breast(2)|endometrium(3)|kidney(1)|large_intestine(4)|lung(6)|ovary(1)|upper_aerodigestive_tract(1)	18		Prostate(47;0.141)		BRCA - Breast invasive adenocarcinoma(232;0.0708)	Tretinoin(DB00755)	GACCAAGCTCGTCCGGGGGAG	0.562000													73	235					0	0	1	0	0
DUSP27	92235	broad.mit.edu	37	1	167096486	167096486	+	Silent	SNP	C	C	A			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr1:167096486C>A	ENST00000361200.2	+	6	2284	c.2118C>A	c.(2116-2118)ccC>ccA	p.P706P	DUSP27_ENST00000271385.5_Silent_p.P706P|DUSP27_ENST00000485151.1_Intron|DUSP27_ENST00000443333.1_Silent_p.P706P			Q5VZP5	DUS27_HUMAN	dual specificity phosphatase 27 (putative)	706					protein dephosphorylation		protein tyrosine/serine/threonine phosphatase activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(11)|liver(1)|lung(46)|ovary(5)|prostate(5)|skin(4)|upper_aerodigestive_tract(3)	89						CCACCACACCCCTGCCTAACC	0.572000													5	48					0.000602214	0.000626895	1	1	0
PBDC1	51260	broad.mit.edu	37	X	75393429	75393429	+	Missense_Mutation	SNP	G	G	A			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chrX:75393429G>A	ENST00000373358.3	+	2	243	c.40G>A	c.(40-42)Gag>Aag	p.E14K	PBDC1_ENST00000373357.3_Missense_Mutation_p.E14K	NM_016500.3	NP_057584.2			polysaccharide biosynthesis domain containing 1																		GGTTTCCGGGGAGTTGGTGTC	0.592000													14	49					0	0	1	0	0
DRD5	1816	broad.mit.edu	37	4	9784050	9784050	+	Missense_Mutation	SNP	G	G	A			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr4:9784050G>A	ENST00000304374.2	+	1	793	c.397G>A	c.(397-399)Gtc>Atc	p.V133I		NM_000798.4	NP_000789.1	P21918	DRD5_HUMAN	dopamine receptor D5	133					activation of adenylate cyclase activity by dopamine receptor signaling pathway|activation of phospholipase C activity by dopamine receptor signaling pathway|cellular calcium ion homeostasis|negative regulation of NAD(P)H oxidase activity|reactive oxygen species metabolic process|synaptic transmission, dopaminergic	integral to plasma membrane				NS(2)|endometrium(8)|kidney(4)|large_intestine(8)|lung(22)|prostate(7)|skin(3)|stomach(2)|urinary_tract(1)	57					Apomorphine(DB00714)|Carphenazine(DB01038)|Fenoldopam(DB00800)|Zuclopenthixol(DB01624)	GAACCTGTGCGTCATCAGCGT	0.622000													16	32					0	0	1	0	0
OR51G2	81282	broad.mit.edu	37	11	4936675	4936675	+	Silent	SNP	C	C	T			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr11:4936675C>T	ENST00000322013.3	-	1	247	c.219G>A	c.(217-219)ctG>ctA	p.L73L	MMP26_ENST00000380390.1_Intron|MMP26_ENST00000477339.1_Intron	NM_001005238.1	NP_001005238.1	Q8NGK0	O51G2_HUMAN	olfactory receptor, family 51, subfamily G, member 2	73					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			autonomic_ganglia(1)|endometrium(1)|large_intestine(9)|lung(12)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;5.06e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00438)|LUSC - Lung squamous cell carcinoma(625;0.19)		CCAGGTCAATCAGAGCCAGCA	0.483000													7	30					0	0	1	0	0
TACC1	6867	broad.mit.edu	37	8	38681515	38681515	+	Missense_Mutation	SNP	G	G	A			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr8:38681515G>A	ENST00000379931.3	+	4	1778	c.1399G>A	c.(1399-1401)Gaa>Aaa	p.E467K	TACC1_ENST00000348567.4_Intron|TACC1_ENST00000520973.1_Intron|TACC1_ENST00000330691.6_Missense_Mutation_p.E29K|TACC1_ENST00000520611.1_Intron|TACC1_ENST00000317827.4_Intron|TACC1_ENST00000276520.8_Intron|TACC1_ENST00000443286.2_Intron|TACC1_ENST00000522752.1_Intron|TACC1_ENST00000520615.1_Intron|TACC1_ENST00000519416.1_Intron|TACC1_ENST00000520340.1_Intron|TACC1_ENST00000518415.1_Intron			O75410	TACC1_HUMAN	transforming, acidic coiled-coil containing protein 1	464	SPAZ 2.				cell cycle|cell division	intermediate filament cytoskeleton|microtubule organizing center|nucleus	protein binding			breast(4)|endometrium(1)|kidney(1)|large_intestine(3)|lung(4)|ovary(1)|skin(3)	17		all_lung(54;0.00292)|Lung NSC(58;0.0115)|Hepatocellular(245;0.065)	LUSC - Lung squamous cell carcinoma(45;1.7e-09)|COAD - Colon adenocarcinoma(9;0.235)			CAGGACTACTGAACAAGTGAA	0.438000													9	210					0	0	1	0	0
POLN	353497	broad.mit.edu	37	4	2082732	2082732	+	Missense_Mutation	SNP	C	C	T			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr4:2082732C>T	ENST00000511885.2	-	23	2693	c.2340G>A	c.(2338-2340)atG>atA	p.M780I	POLN_ENST00000382865.1_Missense_Mutation_p.M780I			Q7Z5Q5	DPOLN_HUMAN	polymerase (DNA directed) nu	780					DNA repair|DNA replication	nucleus	DNA binding|DNA-directed DNA polymerase activity			kidney(6)|large_intestine(5)|liver(1)|lung(8)|ovary(2)|skin(4)|urinary_tract(2)	28			OV - Ovarian serous cystadenocarcinoma(23;0.0955)			AGACATGGATCATGGCCAGCT	0.592000								DNA polymerases (catalytic subunits)					5	97					0	0	1	0	0
IGF2BP3	10643	broad.mit.edu	37	7	23391151	23391151	+	Silent	SNP	G	G	C			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr7:23391151G>C	ENST00000258729.3	-	6	812	c.456C>G	c.(454-456)gcC>gcG	p.A152A	IGF2BP3_ENST00000491719.1_5'UTR	NM_006547.2	NP_006538.2	O00425	IF2B3_HUMAN	insulin-like growth factor 2 mRNA binding protein 3	152	RRM 2.				anatomical structure morphogenesis|negative regulation of translation|translation	cytosol|nucleus	mRNA 3'-UTR binding|mRNA 5'-UTR binding|nucleotide binding|protein binding|translation regulator activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(14)|ovary(2)|prostate(2)|skin(4)|stomach(1)	34						CAGGGATATAGGCTACTTTCA	0.537000													6	98					0	0	1	0	0
SF3B3	23450	broad.mit.edu	37	16	70602960	70602960	+	Silent	SNP	T	T	C			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr16:70602960T>C	ENST00000302516.5	+	23	3391	c.3180T>C	c.(3178-3180)ccT>ccC	p.P1060P		NM_012426.4	NP_036558.3	Q15393	SF3B3_HUMAN	splicing factor 3b, subunit 3, 130kDa	1060					protein complex assembly	catalytic step 2 spliceosome|nucleoplasm|small nuclear ribonucleoprotein complex|U12-type spliceosomal complex	nucleic acid binding|protein binding			breast(2)|endometrium(8)|kidney(2)|large_intestine(8)|liver(3)|lung(21)|ovary(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	53		Ovarian(137;0.0694)				GGCTCCCACCTAACACCAATG	0.547000													3	33					0	0	1	0	0
AP1G1	164	broad.mit.edu	37	16	71805057	71805057	+	Splice_Site	SNP	A	A	G			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr16:71805057A>G	ENST00000299980.4	-	5	1007		c.e5+1		AP1G1_ENST00000393512.3_Splice_Site|AP1G1_ENST00000569748.1_Splice_Site|AP1G1_ENST00000433195.2_Splice_Site|AP1G1_ENST00000423132.2_Splice_Site	NM_001128.5	NP_001119.3	O43747	AP1G1_HUMAN	adaptor-related protein complex 1, gamma 1 subunit						endocytosis|intracellular protein transport|post-Golgi vesicle-mediated transport|regulation of defense response to virus by virus|viral reproduction	clathrin adaptor complex|clathrin coated vesicle membrane|cytosol|Golgi membrane|lysosomal membrane|recycling endosome	kinesin binding|protein transporter activity			breast(1)|endometrium(8)|large_intestine(6)|lung(7)|ovary(4)|pancreas(1)|urinary_tract(1)	28		Ovarian(137;0.125)				AAATTACATTACCATGGTTCT	0.398000													7	61					0	0	1	0	0
LDLRAD4	753	broad.mit.edu	37	18	13645287	13645287	+	Silent	SNP	G	G	A			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr18:13645287G>A	ENST00000361205.4	+	7	1220	c.552G>A	c.(550-552)caG>caA	p.Q184Q	LDLRAD4_ENST00000359446.5_Silent_p.Q184Q|LDLRAD4_ENST00000586765.1_Silent_p.Q129Q|RP11-701H16.4_ENST00000588397.1_RNA|LDLRAD4_ENST00000585931.1_Silent_p.Q107Q|LDLRAD4_ENST00000592991.1_Silent_p.Q86Q|LDLRAD4_ENST00000399848.3_Silent_p.Q166Q|LDLRAD4_ENST00000587757.1_Silent_p.Q147Q	NM_001276249.1|NM_181481.3	NP_001263178.1|NP_852146.1			low density lipoprotein receptor class A domain containing 4																		CTCCTTACCAGGGGCCCTGCA	0.597000													4	117					0	0	1	0	0
MBTD1	54799	broad.mit.edu	37	17	49279000	49279000	+	Missense_Mutation	SNP	T	T	C			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr17:49279000T>C	ENST00000586178.1	-	12	1520	c.1177A>G	c.(1177-1179)Ata>Gta	p.I393V	MBTD1_ENST00000415868.1_Missense_Mutation_p.I393V|MBTD1_ENST00000376381.2_Missense_Mutation_p.I393V	NM_017643.2	NP_060113.2	Q05BQ5	MBTD1_HUMAN	mbt domain containing 1	393					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(1)|ovary(2)|skin(1)|urinary_tract(1)	12			BRCA - Breast invasive adenocarcinoma(22;1.54e-08)			AATGGGTCTATAGCTTCCAAT	0.318000													51	153					0	0	1	0	0
AKAP9	10142	broad.mit.edu	37	7	91708996	91708996	+	Nonsense_Mutation	SNP	C	C	T			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr7:91708996C>T	ENST00000359028.2	+	32	7810	c.7585C>T	c.(7585-7587)Cag>Tag	p.Q2529*	AKAP9_ENST00000356239.3_Nonsense_Mutation_p.Q2517*|AKAP9_ENST00000358100.2_Nonsense_Mutation_p.Q2529*			Q99996	AKAP9_HUMAN	A kinase (PRKA) anchor protein 9	2529	Glu-rich.				G2/M transition of mitotic cell cycle|signal transduction|synaptic transmission|transport	centrosome|cytosol|Golgi apparatus	receptor binding			NS(1)|autonomic_ganglia(2)|breast(14)|central_nervous_system(3)|cervix(1)|endometrium(13)|kidney(12)|large_intestine(35)|lung(49)|ovary(8)|prostate(6)|skin(8)|stomach(1)|urinary_tract(2)	155	all_cancers(62;2.46e-09)|all_epithelial(64;4.42e-08)|Breast(17;0.00206)|all_lung(186;0.185)|all_hematologic(106;0.215)|Lung NSC(181;0.249)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)			AGAACTTACCCAGTGTTATAA	0.333000			T	BRAF	papillary thyroid								13	87					0	0	1	0	0
PHACTR2	9749	broad.mit.edu	37	6	144093548	144093548	+	Nonsense_Mutation	SNP	C	C	A			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr6:144093548C>A	ENST00000427704.2	+	7	1483	c.1353C>A	c.(1351-1353)taC>taA	p.Y451*	PHACTR2_ENST00000305766.6_Nonsense_Mutation_p.Y371*|PHACTR2_ENST00000440869.2_Nonsense_Mutation_p.Y462*|PHACTR2_ENST00000367582.3_Nonsense_Mutation_p.Y382*|PHACTR2_ENST00000367584.4_Nonsense_Mutation_p.Y439*	NM_001100166.1|NM_014721.2	NP_001093636.1|NP_055536.2	O75167	PHAR2_HUMAN	phosphatase and actin regulator 2	451							actin binding|protein phosphatase inhibitor activity			NS(3)|breast(1)|cervix(1)|endometrium(3)|large_intestine(4)|lung(13)|ovary(2)|prostate(1)|upper_aerodigestive_tract(2)	30				OV - Ovarian serous cystadenocarcinoma(155;1.58e-05)|GBM - Glioblastoma multiforme(68;0.0386)		CTATCTTGTACACCGATGATG	0.512000													7	18					1.06961e-07	1.17611e-07	1	1	0
RASGRF2	5924	broad.mit.edu	37	5	80513198	80513198	+	Missense_Mutation	SNP	A	A	G			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr5:80513198A>G	ENST00000265080.4	+	25	3525	c.3458A>G	c.(3457-3459)tAt>tGt	p.Y1153C	CTC-281B15.1_ENST00000511495.1_RNA|CTC-281B15.1_ENST00000503483.2_RNA	NM_006909.2	NP_008840.1	O14827	RGRF2_HUMAN	Ras protein-specific guanine nucleotide-releasing factor 2	1153	Ras-GEF.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|synaptic transmission	cytosol|endoplasmic reticulum membrane|plasma membrane	protein binding|Rho guanyl-nucleotide exchange factor activity			biliary_tract(1)|breast(5)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(15)|lung(28)|ovary(5)|prostate(3)|skin(4)|soft_tissue(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	75		Lung NSC(167;0.00498)|all_lung(232;0.00531)|Ovarian(174;0.0357)		OV - Ovarian serous cystadenocarcinoma(54;4.22e-42)|Epithelial(54;4.04e-35)|all cancers(79;2.52e-29)		GCAGTTCCTTATCTTGGGATG	0.418000													42	88					0	0	1	0	0
EIF2B4	8890	broad.mit.edu	37	2	27592056	27592056	+	Missense_Mutation	SNP	C	C	G			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr2:27592056C>G	ENST00000493344.2	-	3	610	c.298G>C	c.(298-300)Gaa>Caa	p.E100Q	EIF2B4_ENST00000451130.2_Missense_Mutation_p.E99Q|EIF2B4_ENST00000347454.4_Missense_Mutation_p.E79Q|EIF2B4_ENST00000445933.2_Missense_Mutation_p.E78Q			Q9UI10	EI2BD_HUMAN	eukaryotic translation initiation factor 2B, subunit 4 delta, 67kDa	79					myelination|negative regulation of translational initiation in response to stress|oligodendrocyte development|ovarian follicle development|response to glucose stimulus|response to heat|response to peptide hormone stimulus	cytosol|eukaryotic translation initiation factor 2B complex	translation initiation factor activity|translation initiation factor binding			breast(1)|cervix(1)|endometrium(1)|kidney(1)|lung(5)|skin(1)	10	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					ATGCCCGATTCTGGCAGTTCT	0.547000													28	125					0	0	1	0	0
HID1	283987	broad.mit.edu	37	17	72954850	72954850	+	Silent	SNP	G	G	C			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr17:72954850G>C	ENST00000425042.2	-	10	1235	c.1158C>G	c.(1156-1158)ctC>ctG	p.L386L		NM_030630.2	NP_085133.1			HID1 domain containing																		GCACGAAGAAGAGGAATTTCT	0.627000											OREG0024721	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	34					0	0	1	0	0
MYH3	4621	broad.mit.edu	37	17	10543903	10543903	+	Nonsense_Mutation	SNP	G	G	A			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr17:10543903G>A	ENST00000583535.1	-	20	2353	c.2266C>T	c.(2266-2268)Cag>Tag	p.Q756*	MYH3_ENST00000226209.7_Nonsense_Mutation_p.Q756*	NM_002470.3	NP_002461.2	P11055	MYH3_HUMAN	myosin, heavy chain 3, skeletal muscle, embryonic	756	Myosin head-like.				muscle filament sliding|muscle organ development	cytosol|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(8)|kidney(5)|large_intestine(18)|lung(30)|ovary(4)|pancreas(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(5)|urinary_tract(1)	83						AATTTGTACTGAGTGTGGTCA	0.453000													27	164					0	0	1	0	0
FAM50A	9130	broad.mit.edu	37	X	153678776	153678776	+	Missense_Mutation	SNP	G	G	A			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chrX:153678776G>A	ENST00000393600.3	+	13	1126	c.1016G>A	c.(1015-1017)cGc>cAc	p.R339H		NM_004699.3	NP_004690.1	Q14320	FA50A_HUMAN	family with sequence similarity 50, member A	339					spermatogenesis	nucleus				breast(2)|central_nervous_system(1)|lung(9)|ovary(2)|skin(1)	15	all_cancers(53;5.05e-16)|all_epithelial(53;1.87e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					CACTAGATCCGCTGAGCATCC	0.692000													8	18					0	0	1	0	0
CD8A	925	broad.mit.edu	37	2	87016465	87016465	+	Silent	SNP	G	G	T			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr2:87016465G>T	ENST00000409511.2	-	7	1636	c.606C>A	c.(604-606)atC>atA	p.I202I	CD8A_ENST00000352580.3_Intron|CD8A_ENST00000538832.1_Silent_p.I243I|CD8A_ENST00000456996.2_Intron|CD8A_ENST00000283635.3_Silent_p.I202I|CD8A_ENST00000409781.1_Silent_p.I165I	NM_001145873.1	NP_001139345.1	P01732	CD8A_HUMAN	CD8a molecule	202					antigen processing and presentation|regulation of immune response|transmembrane receptor protein tyrosine kinase signaling pathway	extracellular region|integral to plasma membrane|T cell receptor complex	coreceptor activity|MHC class I protein binding			lung(4)|ovary(1)|prostate(2)|urinary_tract(1)	8						AGTAAAGGGTGATAACCAGTG	0.617000													11	172					5.50884e-06	5.97968e-06	1	1	0
C9orf43	257169	broad.mit.edu	37	9	116185655	116185655	+	Missense_Mutation	SNP	G	G	A	rs148106673	byFrequency	TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr9:116185655G>A	ENST00000288462.4	+	7	979	c.533G>A	c.(532-534)cGa>cAa	p.R178Q	C9orf43_ENST00000374165.1_Missense_Mutation_p.R178Q	NM_152786.1	NP_689999.1	Q8TAL5	CI043_HUMAN	chromosome 9 open reading frame 43	178										breast(2)|large_intestine(6)|lung(2)|ovary(1)|pancreas(1)|prostate(3)	15						GCAGGAACACGAGTAGGAACA	0.473000													5	68					0	0	1	0	0
POM121	9883	broad.mit.edu	37	7	72413458	72413458	+	Missense_Mutation	SNP	G	G	A			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr7:72413458G>A	ENST00000395270.1	+	14	3172	c.2131G>A	c.(2131-2133)Gag>Aag	p.E711K	POM121_ENST00000446813.1_Missense_Mutation_p.E711K|POM121_ENST00000257622.4_Missense_Mutation_p.E711K|POM121_ENST00000434423.2_Missense_Mutation_p.E976K|POM121_ENST00000358357.3_Missense_Mutation_p.E711K	NM_001257190.1	NP_001244119.1	Q96HA1	P121A_HUMAN	POM121 transmembrane nucleoporin	976	Pore side (Potential).				carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	endoplasmic reticulum membrane|nuclear membrane|nuclear pore				NS(1)|breast(1)|endometrium(9)|kidney(4)|large_intestine(6)|lung(12)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	41		Lung NSC(55;0.163)				TGGGGCCGCTGAGGGGCAGCC	0.662000													5	117					0	0	1	0	0
PDLIM3	27295	broad.mit.edu	37	4	186446252	186446252	+	Missense_Mutation	SNP	C	C	G			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr4:186446252C>G	ENST00000284767.5	-	2	234	c.167G>C	c.(166-168)gGg>gCg	p.G56A	PDLIM3_ENST00000284770.5_Missense_Mutation_p.G56A|PDLIM3_ENST00000284771.6_Missense_Mutation_p.G56A			Q53GG5	PDLI3_HUMAN	PDZ and LIM domain 3	56	PDZ.					sarcomere	zinc ion binding			breast(2)|endometrium(1)|large_intestine(1)|lung(5)|ovary(2)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	17		all_lung(41;1.03e-13)|Lung NSC(41;2.49e-13)|Melanoma(20;1.91e-06)|Hepatocellular(41;0.00826)|Renal(120;0.00988)|Prostate(90;0.00996)|Colorectal(36;0.0161)|all_hematologic(60;0.0592)|all_neural(102;0.243)		OV - Ovarian serous cystadenocarcinoma(60;1.4e-10)|BRCA - Breast invasive adenocarcinoma(30;8.64e-05)|GBM - Glioblastoma multiforme(59;0.000167)|STAD - Stomach adenocarcinoma(60;0.000828)|LUSC - Lung squamous cell carcinoma(40;0.00984)|COAD - Colon adenocarcinoma(29;0.0115)|READ - Rectum adenocarcinoma(43;0.171)		GGACTCTGTCCCAAAGCCGTC	0.488000													20	184					0	0	1	0	0
ATP8A1	10396	broad.mit.edu	37	4	42553227	42553227	+	Silent	SNP	C	C	T			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr4:42553227C>T	ENST00000381668.5	-	18	1821	c.1590G>A	c.(1588-1590)gtG>gtA	p.V530V	ATP8A1_ENST00000264449.10_Silent_p.V515V	NM_006095.2	NP_006086.1	Q9Y2Q0	AT8A1_HUMAN	ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1	530					ATP biosynthetic process	chromaffin granule membrane|integral to membrane|plasma membrane	aminophospholipid transporter activity|ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|cation-transporting ATPase activity|magnesium ion binding|phospholipid-translocating ATPase activity			NS(1)|central_nervous_system(3)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(13)|lung(18)|pancreas(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(3)	51					Phosphatidylserine(DB00144)	AATCTATAATCACCGAGTCGG	0.348000													7	92					0	0	1	0	0
CXCR2	3579	broad.mit.edu	37	2	219000424	219000424	+	Silent	SNP	G	G	A			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr2:219000424G>A	ENST00000318507.2	+	3	1327	c.900G>A	c.(898-900)gaG>gaA	p.E300E		NM_001557.3	NP_001548.1	P25025	CXCR2_HUMAN	chemokine (C-X-C motif) receptor 2	300					activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|cellular defense response|dendritic cell chemotaxis|inflammatory response|neutrophil activation|neutrophil chemotaxis|positive regulation of cell proliferation	cell surface|integral to plasma membrane|mast cell granule	interleukin-8 receptor activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(11)|skin(1)|stomach(1)	22						ATGCCACCGAGATTCTGGGCA	0.567000													4	87					0	0	1	0	0
MICAL3	57553	broad.mit.edu	37	22	18293533	18293533	+	Missense_Mutation	SNP	C	C	T			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr22:18293533C>T	ENST00000441493.2	-	28	5844	c.5492G>A	c.(5491-5493)cGt>cAt	p.R1831H	MICAL3_ENST00000580469.1_5'UTR|XXbac-B461K10.4_ENST00000476405.1_RNA	NM_015241.2	NP_056056.2	Q7RTP6	MICA3_HUMAN	microtubule associated monooxygenase, calponin and LIM domain containing 3	1831						cytoplasm|cytoskeleton	monooxygenase activity|zinc ion binding			large_intestine(1)|lung(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	4		all_epithelial(15;0.198)		Lung(27;0.0427)		CTTTTGCACACGCCGGGTCAG	0.582000													14	129					0	0	1	0	0
RUNDC3B	154661	broad.mit.edu	37	7	87329767	87329767	+	Missense_Mutation	SNP	C	C	T			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr7:87329767C>T	ENST00000338056.3	+	4	731	c.320C>T	c.(319-321)cCt>cTt	p.P107L	ABCB1_ENST00000265724.3_Intron|RUNDC3B_ENST00000493037.1_Missense_Mutation_p.P90L|RUNDC3B_ENST00000394654.3_Missense_Mutation_p.P90L	NM_001134405.1|NM_138290.2	NP_001127877.1|NP_612147.1	Q96NL0	RUN3B_HUMAN	RUN domain containing 3B	107	RUN.									breast(2)|endometrium(3)|kidney(2)|large_intestine(7)|lung(8)|ovary(1)|prostate(1)|skin(2)	26	Esophageal squamous(14;0.00164)					TATGAAAGTCCTCGTAGCTTC	0.358000													21	65					0	0	1	0	0
FAM114A2	10827	broad.mit.edu	37	5	153381820	153381820	+	Missense_Mutation	SNP	G	G	C			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr5:153381820G>C	ENST00000351797.4	-	11	1323	c.1247C>G	c.(1246-1248)aCt>aGt	p.T416S	FAM114A2_ENST00000522858.1_Missense_Mutation_p.T416S|FAM114A2_ENST00000520313.1_Missense_Mutation_p.T346S|FAM114A2_ENST00000520667.1_Missense_Mutation_p.T416S	NM_018691.2	NP_061161.2	Q9NRY5	F1142_HUMAN	family with sequence similarity 114, member A2	416							purine nucleotide binding			NS(1)|breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(9)|skin(1)|urinary_tract(1)	18						CTGGGAAAGAGTTTGGCTCCT	0.423000													9	106					0	0	1	0	0
DHRS4L2	317749	broad.mit.edu	37	14	24459415	24459415	+	Silent	SNP	T	T	C			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr14:24459415T>C	ENST00000335125.6	+	2	279	c.153T>C	c.(151-153)cgT>cgC	p.R51R	DHRS4L2_ENST00000534993.1_5'UTR|DHRS4L2_ENST00000382755.4_Silent_p.R49R|DHRS4L2_ENST00000545240.1_Silent_p.R51R|DHRS4L2_ENST00000558753.1_Silent_p.R51R|DHRS4L2_ENST00000537912.1_Silent_p.R51R|DHRS4L2_ENST00000543805.1_5'UTR|DHRS4L2_ENST00000397071.1_Silent_p.R51R	NM_198083.3	NP_932349.2	D5KJA1	D5KJA1_HUMAN	dehydrogenase/reductase (SDR family) member 4 like 2	23							binding|oxidoreductase activity			breast(1)|endometrium(2)|kidney(1)|lung(2)|ovary(1)|skin(2)|stomach(1)	10				GBM - Glioblastoma multiforme(265;0.00962)		TCGCCCGGCGTTTGGCCCAGG	0.637000													6	146					0	0	1	0	0
LCE2B	26239	broad.mit.edu	37	1	152659474	152659474	+	Missense_Mutation	SNP	C	C	G			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr1:152659474C>G	ENST00000368780.3	+	2	209	c.155C>G	c.(154-156)tCt>tGt	p.S52C	LCE2B_ENST00000417924.2_Missense_Mutation_p.S52C	NM_014357.4	NP_055172.1	O14633	LCE2B_HUMAN	late cornified envelope 2B	52	Cys-rich.				keratinization					endometrium(1)|large_intestine(1)|lung(4)|ovary(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	11	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			GGTCCCATCTCTGGGGGCTGC	0.637000													18	292					0	0	1	0	0
DHRS9	10170	broad.mit.edu	37	2	169952147	169952147	+	Missense_Mutation	SNP	C	C	T			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr2:169952147C>T	ENST00000327239.4	+	8	2334	c.830C>T	c.(829-831)cCt>cTt	p.P277L	DHRS9_ENST00000602501.1_Missense_Mutation_p.P277L|DHRS9_ENST00000357546.2_Missense_Mutation_p.P277L|DHRS9_ENST00000428522.1_Missense_Mutation_p.P277L|DHRS9_ENST00000421653.1_Missense_Mutation_p.P130L|DHRS9_ENST00000436483.2_Missense_Mutation_p.P277L|DHRS9_ENST00000432060.2_Missense_Mutation_p.P337L|DHRS9_ENST00000412271.1_Missense_Mutation_p.P277L	NM_005771.4	NP_005762.2	Q9BPW9	DHRS9_HUMAN	dehydrogenase/reductase (SDR family) member 9	277					9-cis-retinoic acid biosynthetic process|androgen metabolic process|epithelial cell differentiation|progesterone metabolic process|retinol metabolic process	integral to endoplasmic reticulum membrane|microsome	alcohol dehydrogenase (NAD) activity|binding|racemase and epimerase activity|retinol dehydrogenase activity|testosterone dehydrogenase (NAD+) activity			breast(1)|endometrium(3)|large_intestine(2)|lung(5)|skin(1)|upper_aerodigestive_tract(1)	13						AGTCTCTTCCCTAAGACTCAT	0.423000													9	228					0	0	1	0	0
NPR3	4883	broad.mit.edu	37	5	32712495	32712495	+	Missense_Mutation	SNP	A	A	C			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr5:32712495A>C	ENST00000265074.8	+	1	956	c.613A>C	c.(613-615)Agc>Cgc	p.S205R	NPR3_ENST00000434067.2_Intron|NPR3_ENST00000415167.2_Missense_Mutation_p.S205R|NPR3_ENST00000415685.2_Intron	NM_000908.3|NM_001204375.1	NP_000899.1|NP_001191304.1	P17342	ANPRC_HUMAN	natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C)	205					osteoclast proliferation|positive regulation of urine volume|regulation of blood pressure|regulation of osteoblast proliferation|skeletal system development	integral to membrane	hormone binding|natriuretic peptide receptor activity			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(2)|large_intestine(5)|lung(12)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	24					Nesiritide(DB04899)	ACTGGTCTACAGCGACGACAA	0.637000													18	131					0	0	1	0	0
DYNC2H1	79659	broad.mit.edu	37	11	103058262	103058262	+	Silent	SNP	C	C	T			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr11:103058262C>T	ENST00000375735.2	+	43	7231	c.7087C>T	c.(7087-7089)Cta>Tta	p.L2363L	DYNC2H1_ENST00000398093.3_Silent_p.L2363L|DYNC2H1_ENST00000334267.7_Intron	NM_001080463.1|NM_001377.2	NP_001073932.1|NP_001368.2	Q8NCM8	DYHC2_HUMAN	dynein, cytoplasmic 2, heavy chain 1	2363	AAA 3 (By similarity).				cell projection organization|Golgi organization|microtubule-based movement|multicellular organismal development	cilium axoneme|dynein complex|Golgi apparatus|microtubule|plasma membrane	ATP binding|ATPase activity|microtubule motor activity			NS(1)|endometrium(4)|kidney(5)|large_intestine(9)|lung(9)|ovary(1)|prostate(2)|upper_aerodigestive_tract(2)	33		Acute lymphoblastic leukemia(157;0.000966)|all_hematologic(158;0.00348)		BRCA - Breast invasive adenocarcinoma(274;0.000177)|Epithelial(105;0.0785)		AGATATCAACCTACCTAAACT	0.363000													34	62					0	0	1	0	0
ZCCHC6	79670	broad.mit.edu	37	9	88919847	88919847	+	Missense_Mutation	SNP	A	A	C			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr9:88919847A>C	ENST00000277141.6	-	25	4193	c.1769T>G	c.(1768-1770)aTg>aGg	p.M590R	ZCCHC6_ENST00000375960.2_Missense_Mutation_p.M1065R|ZCCHC6_ENST00000375961.2_Missense_Mutation_p.M1263R|ZCCHC6_ENST00000375957.1_Missense_Mutation_p.M201R|ZCCHC6_ENST00000375963.3_Missense_Mutation_p.M1301R			Q5VYS8	TUT7_HUMAN	zinc finger, CCHC domain containing 6	1301	PAP-associated 1.				RNA 3'-end processing		nucleic acid binding|RNA uridylyltransferase activity|zinc ion binding			breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|liver(1)|lung(14)|ovary(2)|prostate(1)|skin(2)|urinary_tract(1)	46						AAAAGCCTTCATTATAAAATT	0.368000													6	56					0	0	1	0	0
SYT10	341359	broad.mit.edu	37	12	33529823	33529823	+	Missense_Mutation	SNP	G	G	A	rs34361405	byFrequency	TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr12:33529823G>A	ENST00000228567.3	-	7	1810	c.1514C>T	c.(1513-1515)gCg>gTg	p.A505V	SYT10_ENST00000535526.1_Missense_Mutation_p.A324V	NM_198992.3	NP_945343.1	Q6XYQ8	SYT10_HUMAN	synaptotagmin X	505			A -> V (in dbSNP:rs34361405).			cell junction|integral to membrane|synaptic vesicle membrane	metal ion binding|transporter activity	p.A505V(1)		NS(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|liver(1)|lung(18)|ovary(1)|prostate(3)|skin(4)|urinary_tract(1)	42	Lung NSC(5;8.37e-07)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0334)					AAAACTGGTCGCCCGGCCAGG	0.398000													5	43					0	0	1	0	0
PRMT3	10196	broad.mit.edu	37	11	20424503	20424503	+	Nonsense_Mutation	SNP	C	C	A			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr11:20424503C>A	ENST00000331079.6	+	8	961	c.744C>A	c.(742-744)taC>taA	p.Y248*	PRMT3_ENST00000437750.2_Nonsense_Mutation_p.Y186*	NM_001145167.1|NM_005788.3	NP_001138639.1|NP_005779.1	O60678	ANM3_HUMAN	protein arginine methyltransferase 3	248							zinc ion binding			endometrium(2)|kidney(2)|large_intestine(4)|lung(8)|prostate(1)	17						ATTTCATATACCAAAATCCAC	0.353000													30	64					5.8336e-16	6.64455e-16	1	1	0
ADTRP	84830	broad.mit.edu	37	6	11723676	11723676	+	Silent	SNP	G	G	C			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr6:11723676G>C	ENST00000414691.3	-	5	974	c.564C>G	c.(562-564)ctC>ctG	p.L188L	ADTRP_ENST00000229583.5_Silent_p.L206L|ADTRP_ENST00000514824.1_5'UTR|ADTRP_ENST00000379413.2_Silent_p.L188L	NM_032744.3	NP_116133.1	Q96IZ2	CF105_HUMAN	androgen-dependent TFPI-regulating protein	188						integral to membrane											CCAAGAGGCTGAGTTTGGCAA	0.498000													15	466					0	0	1	0	0
ZNF746	155061	broad.mit.edu	37	7	149171598	149171598	+	Silent	SNP	C	C	T			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr7:149171598C>T	ENST00000340622.3	-	7	2092	c.1812G>A	c.(1810-1812)ccG>ccA	p.P604P	ZNF746_ENST00000458143.2_Silent_p.P605P			Q6NUN9	ZN746_HUMAN	zinc finger protein 746	604					negative regulation of transcription, DNA-dependent|neuron death|regulation of cell death|transcription, DNA-dependent	cytoplasm|nucleus	transcription regulatory region DNA binding|ubiquitin protein ligase binding|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(5)|large_intestine(4)|lung(11)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	34	Melanoma(164;0.165)		OV - Ovarian serous cystadenocarcinoma(82;0.00358)			GAGGTGCGGGCGGCGTCGGGA	0.667000													4	11					0	0	1	0	0
TTPA	7274	broad.mit.edu	37	8	63978585	63978585	+	Missense_Mutation	SNP	C	C	A			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr8:63978585C>A	ENST00000260116.4	-	3	461	c.430G>T	c.(430-432)Gta>Tta	p.V144L	TTPA_ENST00000521138.1_Intron	NM_000370.3	NP_000361.1	P49638	TTPA_HUMAN	tocopherol (alpha) transfer protein	144	CRAL-TRIO.				lipid metabolic process		transporter activity|vitamin E binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(8)	15	Breast(64;0.0716)	all_cancers(86;0.145)|Lung NSC(129;0.0324)|all_lung(136;0.0593)|all_epithelial(80;0.123)			Vitamin E(DB00163)	ACCTCCTGTACAATAAGCTCG	0.393000													8	102					0.000157383	0.000165187	1	1	0
NT5E	4907	broad.mit.edu	37	6	86197162	86197162	+	Silent	SNP	C	C	T			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr6:86197162C>T	ENST00000257770.3	+	5	1108	c.1059C>T	c.(1057-1059)tgC>tgT	p.C353C	NT5E_ENST00000369651.3_Silent_p.C353C	NM_002526.3	NP_002517.1	P21589	5NTD_HUMAN	5'-nucleotidase, ecto (CD73)	353					DNA metabolic process|purine base metabolic process|pyrimidine base metabolic process|pyrimidine nucleoside catabolic process	anchored to membrane|cytoplasm|membrane fraction|plasma membrane	5'-nucleotidase activity|nucleotide binding			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(4)|lung(9)|ovary(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	25		all_cancers(76;0.000215)|Acute lymphoblastic leukemia(125;3.66e-08)|all_hematologic(105;8.61e-05)|all_epithelial(107;0.0427)		BRCA - Breast invasive adenocarcinoma(108;0.0417)	Pentoxifylline(DB00806)	CTCAATCATGCCGCTTTAGAG	0.413000													5	144					0	0	1	0	0
PDYN	5173	broad.mit.edu	37	20	1963676	1963676	+	Missense_Mutation	SNP	T	T	C			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr20:1963676T>C	ENST00000217305.2	-	3	280	c.55A>G	c.(55-57)Aca>Gca	p.T19A	PDYN_ENST00000540134.1_Missense_Mutation_p.T19A|RP4-684O24.5_ENST00000446562.1_RNA|PDYN_ENST00000539905.1_Missense_Mutation_p.T19A	NM_001190892.1|NM_001190898.2|NM_024411.4	NP_001177821.1|NP_001177827.1|NP_077722.1	P01213	PDYN_HUMAN	prodynorphin	19					cell death|neuropeptide signaling pathway|synaptic transmission	extracellular region|plasma membrane	opioid peptide activity			endometrium(3)|kidney(1)|large_intestine(5)|lung(22)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	38						CAGTCCGCTGTGGTGGAGGGG	0.562000													13	45					0	0	1	0	0
WDFY3	23001	broad.mit.edu	37	4	85748079	85748079	+	Silent	SNP	G	G	A			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr4:85748079G>A	ENST00000322366.6	-	10	1419	c.1012C>T	c.(1012-1014)Ctg>Ttg	p.L338L	WDFY3_ENST00000295888.4_Silent_p.L338L			Q8IZQ1	WDFY3_HUMAN	WD repeat and FYVE domain containing 3	338						cytoplasmic part|extrinsic to membrane|nuclear envelope	1-phosphatidylinositol binding|metal ion binding|protein binding			breast(5)|central_nervous_system(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(32)|lung(50)|ovary(3)|prostate(5)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	134		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000808)		GAAGTTATCAGATTAACCAGA	0.388000													6	178					0	0	1	0	0
TTLL7	79739	broad.mit.edu	37	1	84387020	84387020	+	Silent	SNP	G	G	C			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr1:84387020G>C	ENST00000260505.8	-	11	1577	c.1200C>G	c.(1198-1200)ctC>ctG	p.L400L	TTLL7_ENST00000477524.1_5'UTR	NM_024686.4	NP_078962.4	Q6ZT98	TTLL7_HUMAN	tubulin tyrosine ligase-like family, member 7	400					cell differentiation|nervous system development|protein modification process	cilium|dendrite|microtubule basal body|perikaryon	tubulin-tyrosine ligase activity			kidney(1)|large_intestine(8)|lung(15)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	29				all cancers(265;0.0126)|Epithelial(280;0.0372)|OV - Ovarian serous cystadenocarcinoma(397;0.16)		TTTGACCATAGAGCCTCCTTT	0.418000													10	138					0	0	1	0	0
KCTD8	386617	broad.mit.edu	37	4	44449606	44449606	+	Missense_Mutation	SNP	C	C	T			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr4:44449606C>T	ENST00000360029.3	-	1	1218	c.935G>A	c.(934-936)aGc>aAc	p.S312N		NM_198353.2	NP_938167.1	Q6ZWB6	KCTD8_HUMAN	potassium channel tetramerization domain containing 8	312						cell junction|postsynaptic membrane|presynaptic membrane|voltage-gated potassium channel complex	voltage-gated potassium channel activity			central_nervous_system(3)|endometrium(4)|kidney(2)|large_intestine(5)|lung(19)|ovary(1)|prostate(3)|upper_aerodigestive_tract(4)	41						GGTGTAGCTGCTCCAGATCTT	0.642000										HNSCC(17;0.042)			10	27					0	0	1	0	0
PLEKHG1	57480	broad.mit.edu	37	6	151152587	151152587	+	Silent	SNP	C	C	T			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr6:151152587C>T	ENST00000367328.1	+	16	2652	c.2340C>T	c.(2338-2340)agC>agT	p.S780S	PLEKHG1_ENST00000358517.2_Silent_p.S780S	NM_001029884.1	NP_001025055.1	Q9ULL1	PKHG1_HUMAN	pleckstrin homology domain containing, family G (with RhoGef domain) member 1	780					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			breast(3)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(10)|lung(19)|ovary(5)|prostate(4)|stomach(1)|urinary_tract(3)	53			BRCA - Breast invasive adenocarcinoma(37;0.0923)	OV - Ovarian serous cystadenocarcinoma(155;6.69e-13)		GCTGTGACAGCCTGAGGCCAT	0.552000													13	42					0	0	1	0	0
CCDC19	25790	broad.mit.edu	37	1	159842768	159842768	+	Missense_Mutation	SNP	C	C	T			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr1:159842768C>T	ENST00000426543.2	-	11	1743	c.1288G>A	c.(1288-1290)Gat>Aat	p.D430N	RP11-190A12.7_ENST00000544342.1_Missense_Mutation_p.D13N|CCDC19_ENST00000476696.1_5'UTR|CCDC19_ENST00000368099.4_Missense_Mutation_p.D515N			Q9UL16	CCD19_HUMAN	coiled-coil domain containing 19	515						mitochondrion|soluble fraction				endometrium(2)|large_intestine(7)|lung(11)|ovary(1)|prostate(2)|skin(1)|urinary_tract(2)	26	all_hematologic(112;0.0597)		BRCA - Breast invasive adenocarcinoma(70;0.151)			TTGATCTCATCGATGCGCTCA	0.577000													44	67					0	0	1	0	0
CDH4	1002	broad.mit.edu	37	20	60470074	60470074	+	Missense_Mutation	SNP	G	G	A			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr20:60470074G>A	ENST00000360469.5	+	8	1247	c.1159G>A	c.(1159-1161)Gac>Aac	p.D387N	CDH4_ENST00000543233.1_Missense_Mutation_p.D313N	NM_001794.3	NP_001785.2	P55283	CADH4_HUMAN	cadherin 4, type 1, R-cadherin (retinal)	387	Cadherin 2.				adherens junction organization|cell junction assembly		calcium ion binding			NS(2)|breast(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|liver(2)|lung(25)|ovary(2)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	74			BRCA - Breast invasive adenocarcinoma(19;2.36e-08)			AGATGTGAATGACAACCCGCC	0.567000													19	171					0	0	1	0	0
ZNF319	57567	broad.mit.edu	37	16	58030938	58030938	+	Missense_Mutation	SNP	G	G	A			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr16:58030938G>A	ENST00000299237.2	-	2	1854	c.1232C>T	c.(1231-1233)tCt>tTt	p.S411F		NM_020807.1	NP_065858.1	Q9P2F9	ZN319_HUMAN	zinc finger protein 319	411					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(2)|lung(4)|ovary(1)|urinary_tract(1)	8						CAGCTCGGCAGATTGGTCAAA	0.652000													12	71					0	0	1	0	0
ZBTB37	84614	broad.mit.edu	37	1	173840134	173840134	+	Silent	SNP	G	G	A			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr1:173840134G>A	ENST00000367704.1	+	3	1170	c.771G>A	c.(769-771)gaG>gaA	p.E257E	ZBTB37_ENST00000367701.4_Silent_p.E257E|ZBTB37_ENST00000427304.1_Silent_p.E257E|ZBTB37_ENST00000432989.1_Silent_p.E257E|ZBTB37_ENST00000367702.1_Silent_p.E257E			Q5TC79	ZBT37_HUMAN	zinc finger and BTB domain containing 37	257					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|large_intestine(1)|lung(4)|ovary(1)|prostate(1)|skin(1)|urinary_tract(4)	13						TTGGGCCTGAGAATCAGCCTT	0.493000													10	63					0	0	1	0	0
CCDC96	257236	broad.mit.edu	37	4	7043387	7043387	+	Missense_Mutation	SNP	C	C	G			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr4:7043387C>G	ENST00000310085.4	-	1	1341	c.1279G>C	c.(1279-1281)Gag>Cag	p.E427Q	RP11-367J11.2_ENST00000500031.1_RNA	NM_153376.2	NP_699207.1	Q2M329	CCD96_HUMAN	coiled-coil domain containing 96	427										endometrium(3)|kidney(1)|large_intestine(3)|lung(2)|skin(1)|urinary_tract(1)	11						AAAAGTTCCTCATTTCGTTCC	0.458000													42	225					0	0	1	0	0
DPYSL5	56896	broad.mit.edu	37	2	27121556	27121556	+	Missense_Mutation	SNP	C	C	G			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr2:27121556C>G	ENST00000288699.6	+	2	347	c.189C>G	c.(187-189)atC>atG	p.I63M	DPYSL5_ENST00000401478.1_Missense_Mutation_p.I63M	NM_001253724.1|NM_020134.3	NP_001240653.1|NP_064519.2	Q9BPU6	DPYL5_HUMAN	dihydropyrimidinase-like 5	63					axon guidance|pyrimidine base catabolic process|signal transduction	cytosol	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides			breast(1)|endometrium(5)|large_intestine(2)|lung(13)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CTGGTGGCATCGACACCAGCA	0.572000													12	44					0	0	1	0	0
TLR10	81793	broad.mit.edu	37	4	38776793	38776793	+	Missense_Mutation	SNP	T	T	C			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr4:38776793T>C	ENST00000308973.4	-	4	1024	c.419A>G	c.(418-420)aAc>aGc	p.N140S	TLR10_ENST00000361424.2_Missense_Mutation_p.N140S|TLR10_ENST00000506111.1_Missense_Mutation_p.N140S|TLR10_ENST00000508334.1_Missense_Mutation_p.N140S	NM_001017388.2|NM_001195107.1|NM_030956.3	NP_001017388.1|NP_001182036.1|NP_112218.2	Q9BXR5	TLR10_HUMAN	toll-like receptor 10	140					inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway	integral to membrane|plasma membrane	transmembrane receptor activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(11)|prostate(1)|urinary_tract(2)	25						GTGTGACATGTTGCCAGCTTC	0.393000													9	101					0	0	1	0	0
ACVR1C	130399	broad.mit.edu	37	2	158401124	158401124	+	Splice_Site	SNP	T	T	C			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr2:158401124T>C	ENST00000243349.7	-	5	1136	c.775_splice	c.e5-1	p.D259_splice	ACVR1C_ENST00000335450.7_Splice_Site_p.D179_splice|ACVR1C_ENST00000348328.5_Splice_Site_p.D102_splice|ACVR1C_ENST00000409680.3_Splice_Site_p.D209_splice	NM_145259.2	NP_660302.2	Q8NER5	ACV1C_HUMAN	activin A receptor, type IC	259	Protein kinase.				apoptosis|cell differentiation|regulation of apoptosis	activin receptor complex	activin receptor activity, type I|ATP binding|transforming growth factor beta receptor activity			NS(1)|breast(1)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(6)|liver(1)|lung(18)|ovary(3)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	42						AGTTCCATTATCTAACAAGAA	0.318000													15	60					0	0	1	0	0
SUPT20H	55578	broad.mit.edu	37	13	37598207	37598207	+	Missense_Mutation	SNP	G	G	C			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr13:37598207G>C	ENST00000360252.4	-	19	1806	c.1559C>G	c.(1558-1560)tCt>tGt	p.S520C	SUPT20H_ENST00000475892.1_Missense_Mutation_p.S519C|SUPT20H_ENST00000464744.1_Missense_Mutation_p.S520C|SUPT20H_ENST00000542180.1_Missense_Mutation_p.S483C|SUPT20H_ENST00000350612.6_Missense_Mutation_p.S519C|SUPT20H_ENST00000356185.3_Missense_Mutation_p.S520C	NM_001278481.1|NM_001278482.1|NM_017569.3	NP_001265410.1|NP_001265411.1|NP_060039.1			suppressor of Ty 20 homolog (S. cerevisiae)									p.S519Y(1)									GGCAGCTGGAGAAAGCATGCT	0.398000													13	82					0	0	1	0	0
RLTPR	146206	broad.mit.edu	37	16	67685742	67685742	+	Missense_Mutation	SNP	G	G	A			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr16:67685742G>A	ENST00000334583.6	+	25	2910	c.2582G>A	c.(2581-2583)aGg>aAg	p.R861K	RLTPR_ENST00000545661.1_Missense_Mutation_p.R825K	NM_001013838.1	NP_001013860.1	Q6F5E8	LR16C_HUMAN	RGD motif, leucine rich repeats, tropomodulin domain and proline-rich containing	861										breast(1)|cervix(1)|endometrium(4)|kidney(1)|lung(9)|urinary_tract(2)	18		Acute lymphoblastic leukemia(13;3.23e-05)|all_hematologic(13;0.00251)|Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0146)|Epithelial(162;0.0481)|all cancers(182;0.232)		GCCTTCActaggctcaggtag	0.637000													11	28					0	0	1	0	0
CLEC18C	283971	broad.mit.edu	37	16	70208872	70208872	+	Missense_Mutation	SNP	C	C	G			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr16:70208872C>G	ENST00000569347.2	+	2	401	c.147C>G	c.(145-147)ttC>ttG	p.F49L	CLEC18C_ENST00000536907.2_Missense_Mutation_p.F49L|CLEC18C_ENST00000541793.2_Missense_Mutation_p.F49L|CLEC18C_ENST00000314151.8_Missense_Mutation_p.F49L|CLEC18C_ENST00000561612.1_3'UTR	NM_173619.2	NP_775890.2			C-type lectin domain family 18, member C											endometrium(3)|large_intestine(6)|lung(1)	10						AGGAGAGTTTCTTGCTCCTCT	0.637000													10	70					0	0	1	0	0
OR5R1	219479	broad.mit.edu	37	11	56185586	56185586	+	Silent	SNP	G	G	T			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr11:56185586G>T	ENST00000312253.1	-	1	122	c.123C>A	c.(121-123)ggC>ggA	p.G41G		NM_001004744.1	NP_001004744.1	Q8NH85	OR5R1_HUMAN	olfactory receptor, family 5, subfamily R, member 1	41					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|liver(1)|lung(17)|ovary(2)|prostate(3)|stomach(1)|upper_aerodigestive_tract(1)	37	Esophageal squamous(21;0.00448)					ACCCAAGATTGCCCAGCACTG	0.448000													26	78					5.61819e-17	6.42802e-17	1	1	0
NUP155	9631	broad.mit.edu	37	5	37364039	37364039	+	Missense_Mutation	SNP	C	C	G			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr5:37364039C>G	ENST00000231498.3	-	3	546	c.343G>C	c.(343-345)Gct>Cct	p.A115P	NUP155_ENST00000513532.1_Missense_Mutation_p.A115P|NUP155_ENST00000381843.2_Missense_Mutation_p.A56P	NM_153485.1	NP_705618.1	O75694	NU155_HUMAN	nucleoporin 155kDa	115					carbohydrate metabolic process|glucose transport|mRNA transport|nucleocytoplasmic transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear membrane|nuclear pore	protein binding|structural constituent of nuclear pore|transporter activity			endometrium(1)|kidney(16)|large_intestine(5)|lung(29)|ovary(2)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	62	all_lung(31;0.000137)		COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			GTGAGCCAAGCTCTGCTGATA	0.398000													11	240					0	0	1	0	0
VWA2	340706	broad.mit.edu	37	10	116046244	116046244	+	Missense_Mutation	SNP	G	G	T			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr10:116046244G>T	ENST00000603594.1	+	11	1865	c.1544G>T	c.(1543-1545)gGg>gTg	p.G515V	VWA2_ENST00000392982.3_Missense_Mutation_p.G515V	NM_001272046.1	NP_001258975.1	Q5GFL6	VWA2_HUMAN	von Willebrand factor A domain containing 2	515	VWFA 2.					extracellular region				central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(7)|lung(6)|ovary(2)|prostate(1)|skin(1)|stomach(1)	26				Epithelial(162;0.036)|all cancers(201;0.0793)		GAGCTGCAGGGGAAGCTGTGC	0.622000													5	46					3.59834e-05	3.84024e-05	1	1	0
MAML2	84441	broad.mit.edu	37	11	95718743	95718743	+	Missense_Mutation	SNP	C	C	T			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr11:95718743C>T	ENST00000524717.1	-	4	3691	c.2407G>A	c.(2407-2409)Gac>Aac	p.D803N		NM_032427.1	NP_115803.1	Q8IZL2	MAML2_HUMAN	mastermind-like 2 (Drosophila)	803					Notch signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear speck	transcription coactivator activity		CRTC3/MAML2(26)|CRTC1/MAML2(516)	breast(2)|cervix(1)|endometrium(11)|kidney(4)|large_intestine(8)|lung(12)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	43		Acute lymphoblastic leukemia(157;2.63e-05)|all_hematologic(158;0.00837)				CTTCTTTGGTCTTTATAATCT	0.333000			T	"""MECT1, CRTC3"""	salivary gland mucoepidermoid								7	34					0	0	1	0	0
PCDHB12	56124	broad.mit.edu	37	5	140589992	140589992	+	Missense_Mutation	SNP	T	T	C			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr5:140589992T>C	ENST00000239450.2	+	1	1702	c.1513T>C	c.(1513-1515)Tcc>Ccc	p.S505P	PCDHB12_ENST00000541609.1_Missense_Mutation_p.S168P	NM_018932.3	NP_061755.1	Q9Y5F1	PCDBC_HUMAN		505	Cadherin 5.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			NS(1)|breast(3)|endometrium(10)|large_intestine(17)|lung(38)|ovary(3)|pancreas(1)|prostate(2)|skin(7)|stomach(1)	83			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CTCCCTGGTCTCCATCAACGC	0.672000													9	139					0	0	1	0	0
HNF4A	3172	broad.mit.edu	37	20	43034712	43034712	+	Missense_Mutation	SNP	G	G	C			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr20:43034712G>C	ENST00000316099.3	+	2	219	c.130G>C	c.(130-132)Gaa>Caa	p.E44Q	HNF4A_ENST00000457232.1_Missense_Mutation_p.E22Q|HNF4A_ENST00000415691.1_Missense_Mutation_p.E44Q|HNF4A_ENST00000443598.2_Missense_Mutation_p.E44Q	NM_000457.4|NM_001258355.1	NP_000448.3|NP_001245284.1	P41235	HNF4A_HUMAN	hepatocyte nuclear factor 4, alpha	44					blood coagulation|endocrine pancreas development|glucose homeostasis|negative regulation of cell growth|negative regulation of cell proliferation|ornithine metabolic process|phospholipid homeostasis|positive regulation of cholesterol homeostasis|regulation of growth hormone receptor signaling pathway|regulation of insulin secretion|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to glucose stimulus|triglyceride homeostasis|xenobiotic metabolic process	cytoplasm	activating transcription factor binding|protein homodimerization activity|receptor binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|steroid hormone receptor activity|transcription regulatory region DNA binding|zinc ion binding			endometrium(4)|large_intestine(7)|lung(17)|ovary(1)|pancreas(1)|skin(2)|urinary_tract(2)	34		Myeloproliferative disorder(115;0.0122)	COAD - Colon adenocarcinoma(18;0.00189)			GTCCCCATCAGAAGGCACCAA	0.627000													31	212					0	0	1	0	0
EP300	2033	broad.mit.edu	37	22	41513481	41513481	+	Missense_Mutation	SNP	G	G	T			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr22:41513481G>T	ENST00000263253.7	+	2	1604	c.385G>T	c.(385-387)Gca>Tca	p.A129S		NM_001429.3	NP_001420.2	Q09472	EP300_HUMAN	E1A binding protein p300	129	Interaction with ALX1.				apoptosis|cell cycle|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|histone H4 acetylation|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of androgen receptor signaling pathway|response to estrogen stimulus|response to hypoxia	centrosome|histone acetyltransferase complex	androgen receptor binding|beta-catenin binding|DNA binding|histone acetyltransferase activity|RNA polymerase II activating transcription factor binding|transcription coactivator activity|zinc ion binding			NS(2)|breast(11)|central_nervous_system(7)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(31)|kidney(5)|large_intestine(31)|liver(2)|lung(33)|ovary(2)|pancreas(4)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(16)	171						AATGACACAGGCAGGCTTGAC	0.527000			"""T,  N, F, Mis, O"""	"""MLL, RUNXBP2"""	"""colorectal, breast, pancreatic, AML, ALL, DLBCL"""				Rubinstein-Taybi syndrome				24	85					1.85244e-09	2.05467e-09	1	1	0
PCDHA9	9752	broad.mit.edu	37	5	140229382	140229382	+	Silent	SNP	A	A	G	rs144490151		TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr5:140229382A>G	ENST00000378122.3	+	1	2026	c.1302A>G	c.(1300-1302)tcA>tcG	p.S434S	PCDHA5_ENST00000529619.1_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA9_ENST00000532602.1_Silent_p.S434S|PCDHA4_ENST00000512229.2_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA7_ENST00000525929.1_Intron	NM_014005.3	NP_054724.1														breast(1)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|lung(18)|ovary(4)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	59			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCTCGCCTTCACTGTGGGCCA	0.622000													5	156					0	0	1	0	0
FAT4	79633	broad.mit.edu	37	4	126412508	126412508	+	Missense_Mutation	SNP	C	C	G			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr4:126412508C>G	ENST00000394329.3	+	17	14544	c.14531C>G	c.(14530-14532)tCc>tGc	p.S4844C	FAT4_ENST00000335110.5_Missense_Mutation_p.S3085C	NM_024582.4	NP_078858.4	Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	4844					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						GATAGTGACTCCCATGAATCT	0.453000													10	111					0	0	1	0	0
TMF1	7110	broad.mit.edu	37	3	69084235	69084235	+	Missense_Mutation	SNP	G	G	C			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr3:69084235G>C	ENST00000543976.1	-	9	2438	c.2192C>G	c.(2191-2193)aCa>aGa	p.T731R	CTD-2013N24.2_ENST00000596732.1_RNA|CTD-2013N24.2_ENST00000598783.1_RNA|CTD-2013N24.2_ENST00000596523.1_RNA|CTD-2013N24.2_ENST00000601735.1_RNA|CTD-2013N24.2_ENST00000599467.1_RNA|TMF1_ENST00000398559.2_Missense_Mutation_p.T728R|CTD-2013N24.2_ENST00000595925.1_RNA|CTD-2013N24.2_ENST00000601511.1_RNA|CTD-2013N24.2_ENST00000597950.1_RNA|CTD-2013N24.2_ENST00000482368.2_RNA	NM_007114.2	NP_009045.2	P82094	TMF1_HUMAN	TATA element modulatory factor 1	728					regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	Golgi membrane|nucleus	DNA binding|protein binding|transcription cofactor activity			cervix(1)|kidney(1)|large_intestine(4)|lung(13)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	22		Lung NSC(201;0.0193)|Prostate(884;0.174)		BRCA - Breast invasive adenocarcinoma(55;4.48e-05)|Epithelial(33;0.000274)|LUSC - Lung squamous cell carcinoma(21;0.0123)|KIRC - Kidney renal clear cell carcinoma(39;0.211)|Kidney(39;0.247)		CGCTTGTTCTGTACGCTGCAA	0.438000													28	148					0	0	1	0	0
RPS11	6205	broad.mit.edu	37	19	50002790	50002790	+	Silent	SNP	C	C	T			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr19:50002790C>T	ENST00000270625.2	+	5	458	c.375C>T	c.(373-375)atC>atT	p.I125I	RPS11_ENST00000599561.1_3'UTR|RPS11_ENST00000594493.1_Silent_p.I46I	NM_001015.4	NP_001006.1	P62280	RS11_HUMAN	ribosomal protein S11	125					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic small ribosomal subunit	protein binding|rRNA binding|structural constituent of ribosome			kidney(1)|large_intestine(1)|lung(3)|skin(1)|urinary_tract(1)	7		all_lung(116;1.62e-07)|Lung NSC(112;8.47e-07)|all_neural(266;0.0381)|Ovarian(192;0.0392)		OV - Ovarian serous cystadenocarcinoma(262;0.00206)|GBM - Glioblastoma multiforme(486;0.0245)		TCGGTGACATCGTCACAGTGG	0.632000													5	43					0	0	1	0	0
PARD6G	84552	broad.mit.edu	37	18	77918269	77918269	+	Missense_Mutation	SNP	G	G	C			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr18:77918269G>C	ENST00000353265.3	-	3	713	c.516C>G	c.(514-516)ttC>ttG	p.F172L	AC139100.2_ENST00000589574.1_Intron|AC139100.2_ENST00000586421.1_Intron|AC139100.2_ENST00000587254.1_Intron|AC139100.2_ENST00000585422.1_Intron	NM_032510.3	NP_115899.1	Q9BYG4	PAR6G_HUMAN	par-6 family cell polarity regulator gamma	172	Interaction with PARD3 and CDC42 (By similarity).|PDZ.				cell cycle|cell division|tight junction assembly	cytosol|tight junction	protein binding			haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(1)|skin(1)|upper_aerodigestive_tract(1)	8		all_cancers(4;5.63e-22)|all_epithelial(4;5.86e-15)|all_lung(4;1.32e-05)|Ovarian(4;1.33e-05)|Lung NSC(4;2.77e-05)|Esophageal squamous(42;0.0157)|all_hematologic(56;0.13)|Melanoma(33;0.144)		Epithelial(2;1.48e-13)|all cancers(1;5.77e-13)|OV - Ovarian serous cystadenocarcinoma(15;2.74e-10)|BRCA - Breast invasive adenocarcinoma(31;0.00166)|STAD - Stomach adenocarcinoma(84;0.18)|Lung(128;0.23)		CGCGGATGTAGAAGCCCAGCG	0.687000													7	14					0	0	1	0	0
ZNF415	55786	broad.mit.edu	37	19	53619585	53619585	+	Nonsense_Mutation	SNP	G	G	A			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr19:53619585G>A	ENST00000455735.2	-	4	375	c.55C>T	c.(55-57)Cag>Tag	p.Q19*	ZNF415_ENST00000597503.1_Silent_p.Y39Y|ZNF415_ENST00000243643.4_Silent_p.Y39Y|ZNF415_ENST00000595193.1_Silent_p.Y39Y|ZNF415_ENST00000595813.1_Silent_p.Y39Y|ZNF415_ENST00000594011.1_Silent_p.Y39Y|ZNF415_ENST00000500065.4_Silent_p.Y39Y|ZNF415_ENST00000599261.1_Silent_p.Y39Y|ZNF415_ENST00000597748.1_Silent_p.Y39Y|ZNF415_ENST00000448501.1_Nonsense_Mutation_p.Q19*|ZNF415_ENST00000440291.1_5'UTR|ZNF415_ENST00000601493.1_Intron|ZNF415_ENST00000601215.1_Intron|ZNF415_ENST00000596683.1_5'UTR|ZNF415_ENST00000600574.1_Silent_p.Y39Y|ZNF415_ENST00000421033.1_Nonsense_Mutation_p.Q19*			Q09FC8	ZN415_HUMAN	zinc finger protein 415	19					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|microtubule cytoskeleton|nucleolus	DNA binding|zinc ion binding			breast(1)|kidney(3)|large_intestine(8)|lung(11)|ovary(2)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	31				GBM - Glioblastoma multiforme(134;0.0191)		CCAGGTTCCTGTAGTTCTCCA	0.473000													53	157					0	0	1	0	0
FUNDC1	139341	broad.mit.edu	37	X	44383462	44383462	+	Silent	SNP	C	C	T			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chrX:44383462C>T	ENST00000378045.4	-	5	618	c.450G>A	c.(448-450)ttG>ttA	p.L150L	FUNDC1_ENST00000483115.1_5'UTR	NM_173794.3	NP_776155.1	Q8IVP5	FUND1_HUMAN	FUN14 domain containing 1	150										breast(1)|large_intestine(2)|lung(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	6						CAAGTCCGAGCAAAAAGCCTC	0.378000													9	12					0	0	1	0	0
PEX5L	51555	broad.mit.edu	37	3	179593188	179593188	+	Missense_Mutation	SNP	C	C	T			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr3:179593188C>T	ENST00000467460.1	-	6	913	c.583G>A	c.(583-585)Gag>Aag	p.E195K	PEX5L_ENST00000472994.1_Missense_Mutation_p.E136K|PEX5L_ENST00000468741.1_Missense_Mutation_p.E3K|PEX5L_ENST00000467440.2_5'UTR|PEX5L_ENST00000465751.1_Missense_Mutation_p.E171K|PEX5L_ENST00000464614.1_Missense_Mutation_p.E87K|PEX5L_ENST00000392649.3_Missense_Mutation_p.E87K|PEX5L_ENST00000263962.8_Missense_Mutation_p.E193K|PEX5L-AS1_ENST00000466064.1_RNA|PEX5L_ENST00000485199.1_Missense_Mutation_p.E160K|PEX5L_ENST00000476138.1_Missense_Mutation_p.E152K	NM_001256751.1|NM_016559.2	NP_001243680.1|NP_057643.1	Q8IYB4	PEX5R_HUMAN	peroxisomal biogenesis factor 5-like	195					protein import into peroxisome matrix|regulation of cAMP-mediated signaling	cytosol|peroxisomal membrane	peroxisome matrix targeting signal-1 binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(23)|ovary(3)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	49	all_cancers(143;3.94e-14)|Ovarian(172;0.0338)|Breast(254;0.183)		OV - Ovarian serous cystadenocarcinoma(80;1.75e-26)|GBM - Glioblastoma multiforme(14;0.000518)			GATTTTCTCTCTGCCATTGGA	0.388000													5	168					0	0	1	0	0
TVP23C-CDRT4	100533496	broad.mit.edu	37	17	15458637	15458637	+	Silent	SNP	C	C	T			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr17:15458637C>T	ENST00000522212.2	-	2	166	c.54G>A	c.(52-54)gcG>gcA	p.A18A	TVP23C_ENST00000438826.3_Silent_p.A18A|TVP23C_ENST00000225576.3_Silent_p.A18A|TVP23C_ENST00000428082.2_Silent_p.A18A|TVP23C_ENST00000518321.1_Silent_p.A18A|TVP23C_ENST00000584811.1_5'UTR|TVP23C_ENST00000519970.1_5'UTR	NM_001204478.1	NP_001191407.1																					TCTCCTCTTCCGCATCAAACA	0.398000													8	200					0	0	1	0	0
RIPK2	8767	broad.mit.edu	37	8	90782102	90782102	+	Missense_Mutation	SNP	G	G	C			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr8:90782102G>C	ENST00000220751.4	+	4	900	c.586G>C	c.(586-588)Gaa>Caa	p.E196Q	RIPK2_ENST00000540020.1_Missense_Mutation_p.E59Q	NM_003821.5	NP_003812.1	O43353	RIPK2_HUMAN	receptor-interacting serine-threonine kinase 2	196	Protein kinase.				activation of MAPK activity|anti-apoptosis|apoptosis|inflammatory response|innate immune response|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of protein ubiquitination|stress-activated MAPK cascade|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol	ATP binding|CARD domain binding|LIM domain binding|protein homodimerization activity|protein serine/threonine kinase activity|signal transducer activity			kidney(1)|large_intestine(3)|lung(2)|ovary(2)|prostate(2)	10			BRCA - Breast invasive adenocarcinoma(11;0.0474)			TATGCCACCTGAAAACTATGA	0.418000													56	244					0	0	1	0	0
NCOR1	9611	broad.mit.edu	37	17	15942786	15942786	+	Missense_Mutation	SNP	C	C	T			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr17:15942786C>T	ENST00000268712.3	-	44	7173	c.6916G>A	c.(6916-6918)Gag>Aag	p.E2306K	NCOR1_ENST00000395851.1_Missense_Mutation_p.E2203K|NCOR1_ENST00000395857.3_Missense_Mutation_p.E890K	NM_006311.3	NP_006302.2	O75376	NCOR1_HUMAN	nuclear receptor corepressor 1	2306	Interaction with C1D (By similarity).				cellular lipid metabolic process|chromatin modification|negative regulation of JNK cascade|regulation of glycolysis by negative regulation of transcription from an RNA polymerase II promoter|regulation of lipid transport by negative regulation of transcription from an RNA polymerase II promoter|spindle assembly|transcription from RNA polymerase II promoter	nuclear chromatin|spindle microtubule|transcriptional repressor complex	histone deacetylase binding|transcription corepressor activity|transcription regulatory region DNA binding			NS(2)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(17)|lung(26)|ovary(1)|prostate(7)|skin(2)|upper_aerodigestive_tract(6)|urinary_tract(10)	107				UCEC - Uterine corpus endometrioid carcinoma (92;0.101)		CTTCGTGTCTCACCACTGGTC	0.483000													6	108					0	0	1	0	0
RP1	6101	broad.mit.edu	37	8	55538911	55538911	+	Silent	SNP	T	T	C			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr8:55538911T>C	ENST00000220676.1	+	4	2617	c.2469T>C	c.(2467-2469)ttT>ttC	p.F823F		NM_006269.1	NP_006260.1	P56715	RP1_HUMAN	retinitis pigmentosa 1 (autosomal dominant)	823					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			NS(4)|breast(6)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(29)|lung(69)|ovary(6)|pancreas(1)|prostate(9)|skin(17)|upper_aerodigestive_tract(3)|urinary_tract(2)	169		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			TTCATGTATTTAACATCCTTG	0.328000													6	138					0	0	1	0	0
SLC9B1	150159	broad.mit.edu	37	4	103822451	103822451	+	Silent	SNP	G	G	A			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr4:103822451G>A	ENST00000296422.7	-	12	1512	c.1371C>T	c.(1369-1371)gtC>gtT	p.V457V	SLC9B1_ENST00000394789.3_Intron|SLC9B1_ENST00000512651.2_5'UTR	NM_139173.3	NP_631912.2	Q4ZJI4	NHDC1_HUMAN	solute carrier family 9, subfamily B (NHA1, cation proton antiporter 1), member 1	457						integral to membrane	solute:hydrogen antiporter activity										GGGGTGCGGAGACTCTTGCTG	0.423000													5	220					0	0	1	0	0
SH3GL3	6457	broad.mit.edu	37	15	84241424	84241424	+	Missense_Mutation	SNP	C	C	G			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr15:84241424C>G	ENST00000324537.5	+	8	955	c.463C>G	c.(463-465)Caa>Gaa	p.Q155E	SH3GL3_ENST00000427482.2_Missense_Mutation_p.Q147E|SH3GL3_ENST00000434347.1_Missense_Mutation_p.Q155E|SH3GL3_ENST00000535412.1_Missense_Mutation_p.Q147E			Q99963	SH3G3_HUMAN	SH3-domain GRB2-like 3	147	BAR.				central nervous system development|endocytosis|signal transduction	early endosome membrane	identical protein binding|lipid binding			central_nervous_system(1)|endometrium(3)|large_intestine(9)|lung(11)|ovary(1)|pancreas(1)|skin(3)|urinary_tract(1)	30						TCAGTTACTACAAGATAAAGA	0.323000													9	54					0	0	1	0	0
ZCCHC6	79670	broad.mit.edu	37	9	88932136	88932136	+	Missense_Mutation	SNP	G	G	A			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr9:88932136G>A	ENST00000277141.6	-	18	3563	c.1139C>T	c.(1138-1140)tCa>tTa	p.S380L	ZCCHC6_ENST00000375960.2_Missense_Mutation_p.S855L|ZCCHC6_ENST00000375961.2_Missense_Mutation_p.S1091L|ZCCHC6_ENST00000375957.1_Missense_Mutation_p.S29L|ZCCHC6_ENST00000375963.3_Missense_Mutation_p.S1091L			Q5VYS8	TUT7_HUMAN	zinc finger, CCHC domain containing 6	1091					RNA 3'-end processing		nucleic acid binding|RNA uridylyltransferase activity|zinc ion binding			breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|liver(1)|lung(14)|ovary(2)|prostate(1)|skin(2)|urinary_tract(1)	46						AGAGGTACCTGAATGTTTTCT	0.363000													8	124					0	0	1	0	0
GSTP1	2950	broad.mit.edu	37	11	67353607	67353607	+	Silent	SNP	G	G	T			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr11:67353607G>T	ENST00000398606.3	+	6	618	c.369G>T	c.(367-369)ctG>ctT	p.L123L	GSTP1_ENST00000498765.1_3'UTR|GSTP1_ENST00000398603.1_Intron	NM_000852.3	NP_000843.1	P09211	GSTP1_HUMAN	glutathione S-transferase pi 1	123	GST C-terminal.				anti-apoptosis|cellular response to lipopolysaccharide|central nervous system development|common myeloid progenitor cell proliferation|glutathione metabolic process|negative regulation of acute inflammatory response|negative regulation of ERK1 and ERK2 cascade|negative regulation of fibroblast proliferation|negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of interleukin-1 beta production|negative regulation of JUN kinase activity|negative regulation of leukocyte proliferation|negative regulation of monocyte chemotactic protein-1 production|negative regulation of necrotic cell death|negative regulation of nitric-oxide synthase 2 biosynthetic process|negative regulation of stress-activated MAPK cascade|negative regulation of tumor necrosis factor production|nitric oxide storage|positive regulation of superoxide anion generation|response to reactive oxygen species|xenobiotic metabolic process	cytosol|protein complex	dinitrosyl-iron complex binding|glutathione transferase activity|JUN kinase binding|kinase regulator activity|nitric oxide binding|S-nitrosoglutathione binding			central_nervous_system(1)|cervix(1)|endometrium(4)|lung(2)|ovary(1)	9					Ethacrynic acid(DB00903)|Glutathione(DB00143)	TGAAGGCACTGCCCGGGCAAC	0.597000													6	33					0.217242	0.217242	1	1	0
CNR2	1269	broad.mit.edu	37	1	24201772	24201772	+	Silent	SNP	G	G	A	rs142210955		TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr1:24201772G>A	ENST00000536471.1	-	3	594	c.336C>T	c.(334-336)agC>agT	p.S112S	CNR2_ENST00000374472.4_Silent_p.S112S			P34972	CNR2_HUMAN	cannabinoid receptor 2 (macrophage)	112					behavior|G-protein signaling, coupled to cyclic nucleotide second messenger|immune response|inflammatory response	dendrite|integral to plasma membrane|perikaryon	cannabinoid receptor activity			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|lung(9)|pancreas(1)|skin(2)|stomach(6)|upper_aerodigestive_tract(2)	26		Colorectal(325;3.46e-05)|Renal(390;0.000219)|Lung NSC(340;0.000233)|all_lung(284;0.000321)|Ovarian(437;0.00348)|Breast(348;0.00957)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;1.32e-24)|Colorectal(126;6.09e-08)|COAD - Colon adenocarcinoma(152;3.33e-06)|GBM - Glioblastoma multiforme(114;2.9e-05)|BRCA - Breast invasive adenocarcinoma(304;0.00101)|KIRC - Kidney renal clear cell carcinoma(1967;0.00359)|STAD - Stomach adenocarcinoma(196;0.0131)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.146)	Nabilone(DB00486)	TCATAGTCACGCTGCCAATCT	0.527000													4	111					0	0	1	0	0
SGK3	23678	broad.mit.edu	37	8	67740902	67740902	+	Nonsense_Mutation	SNP	C	C	G			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr8:67740902C>G	ENST00000396596.1	+	7	645	c.431C>G	c.(430-432)tCa>tGa	p.S144*	SGK3_ENST00000522398.1_Nonsense_Mutation_p.S144*|C8orf44-SGK3_ENST00000519289.1_Nonsense_Mutation_p.S144*|SGK3_ENST00000345714.4_Nonsense_Mutation_p.S144*|SGK3_ENST00000520976.1_Nonsense_Mutation_p.S144*|SGK3_ENST00000521198.2_Nonsense_Mutation_p.S144*	NM_013257.4	NP_037389.4	Q96BR1	SGK3_HUMAN	serum/glucocorticoid regulated kinase family, member 3	144					cell communication|response to stress	cytoplasmic membrane-bounded vesicle|early endosome	ATP binding|phosphatidylinositol binding|protein serine/threonine kinase activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(9)|ovary(1)|upper_aerodigestive_tract(1)	18	Breast(64;0.186)	Lung NSC(129;0.0908)|all_lung(136;0.152)	Epithelial(68;0.0046)|OV - Ovarian serous cystadenocarcinoma(28;0.0112)|all cancers(69;0.0141)|BRCA - Breast invasive adenocarcinoma(89;0.206)			CACTCTACCTCACAGAACATC	0.323000													20	218					0	0	1	0	0
PCDH9	5101	broad.mit.edu	37	13	67801523	67801523	+	Silent	SNP	A	A	G			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr13:67801523A>G	ENST00000544246.1	-	2	1741	c.1050T>C	c.(1048-1050)gaT>gaC	p.D350D	PCDH9_ENST00000328454.5_Silent_p.D350D|PCDH9_ENST00000377865.2_Silent_p.D350D|PCDH9_ENST00000377861.3_Silent_p.D350D|PCDH9_ENST00000456367.1_Silent_p.D350D	NM_203487.2	NP_982354.1	Q9HC56	PCDH9_HUMAN	protocadherin 9	350	Cadherin 3.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(2)|central_nervous_system(3)|cervix(2)|endometrium(7)|kidney(4)|large_intestine(33)|lung(30)|ovary(5)|pancreas(2)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(5)|urinary_tract(3)	103		Hepatocellular(98;0.0906)|Breast(118;0.107)		GBM - Glioblastoma multiforme(99;0.00819)		TATCATTTACATCGGTGACAT	0.448000													17	180					0	0	1	0	0
LDB3	11155	broad.mit.edu	37	10	88478496	88478496	+	Missense_Mutation	SNP	G	G	C			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr10:88478496G>C	ENST00000429277.2	+	12	2030	c.1885G>C	c.(1885-1887)Gcc>Ccc	p.A629P	LDB3_ENST00000352360.5_Missense_Mutation_p.A367P|LDB3_ENST00000458213.2_Missense_Mutation_p.A514P|LDB3_ENST00000263066.6_Missense_Mutation_p.A514P|LDB3_ENST00000361373.4_Missense_Mutation_p.A624P	NM_001171610.1	NP_001165081.1	O75112	LDB3_HUMAN	LIM domain binding 3	624	LIM zinc-binding 2.					cytoskeleton|perinuclear region of cytoplasm|pseudopodium	zinc ion binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(5)|lung(9)|ovary(3)|prostate(1)|soft_tissue(1)	25						AGTAATGCATGCCTTGAGACA	0.587000													44	87					0	0	1	0	0
OR2AE1	81392	broad.mit.edu	37	7	99474188	99474188	+	Silent	SNP	G	G	A			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr7:99474188G>A	ENST00000316368.2	-	1	492	c.469C>T	c.(469-471)Cta>Tta	p.L157L		NM_001005276.1	NP_001005276.1	Q8NHA4	O2AE1_HUMAN	olfactory receptor, family 2, subfamily AE, member 1	157					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(3)|prostate(2)	11	Esophageal squamous(72;0.0166)|Lung NSC(181;0.0211)|all_lung(186;0.0323)					ATGTGAATTAGGGAGTTCACG	0.507000													4	130					0	0	1	0	0
RAB12	201475	broad.mit.edu	37	18	8624994	8624994	+	Missense_Mutation	SNP	C	C	G			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr18:8624994C>G	ENST00000329286.6	+	2	568	c.285C>G	c.(283-285)atC>atG	p.I95M		NM_001025300.2	NP_001020471.2	Q6IQ22	RAB12_HUMAN	RAB12, member RAS oncogene family	95					protein transport|small GTPase mediated signal transduction	Golgi membrane	GTP binding			breast(1)|lung(4)|prostate(1)|urinary_tract(1)	7						GATTACAGATCTGGTAAGTGG	0.358000													21	122					0	0	1	0	0
RGPD8	727851	broad.mit.edu	37	2	113146877	113146877	+	Silent	SNP	G	G	A			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr2:113146877G>A	ENST00000302558.3	-	20	3836	c.3645C>T	c.(3643-3645)gtC>gtT	p.V1215V	RGPD8_ENST00000409750.1_Silent_p.V1075V	NM_001164463.1	NP_001157935.1			RANBP2-like and GRIP domain containing 8											endometrium(4)|kidney(1)|lung(1)|prostate(3)|urinary_tract(1)	10						CTTCCTCAGTGACTTTTGTTT	0.418000													13	521					0	0	1	0	0
TUBA3E	112714	broad.mit.edu	37	2	130951771	130951771	+	Missense_Mutation	SNP	C	C	T			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr2:130951771C>T	ENST00000312988.7	-	4	744	c.644G>A	c.(643-645)cGc>cAc	p.R215H		NM_207312.2	NP_997195.1	Q6PEY2	TBA3E_HUMAN	tubulin, alpha 3e	215					microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|structural molecule activity			endometrium(4)|kidney(7)|large_intestine(6)|lung(9)|skin(2)	28	Colorectal(110;0.1)					GTCCAGGTTGCGCCGACATAT	0.552000													5	156					0	0	1	0	0
TEKT5	146279	broad.mit.edu	37	16	10729668	10729668	+	Silent	SNP	C	C	G			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr16:10729668C>G	ENST00000283025.2	-	6	1265	c.1194G>C	c.(1192-1194)cgG>cgC	p.R398R	TEKT5_ENST00000574923.1_5'UTR	NM_144674.1	NP_653275.1	Q96M29	TEKT5_HUMAN	tektin 5	398					microtubule cytoskeleton organization	cilium axoneme|flagellar axoneme|microtubule				breast(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(9)|lung(9)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(4)	34						GGCGCCGGGTCCGGCACTCCA	0.622000													14	174					0	0	1	0	0
FMNL2	114793	broad.mit.edu	37	2	153494169	153494169	+	Missense_Mutation	SNP	G	G	A			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr2:153494169G>A	ENST00000288670.9	+	23	3294	c.2927G>A	c.(2926-2928)cGg>cAg	p.R976Q	FMNL2_ENST00000475377.2_Missense_Mutation_p.R351Q	NM_052905.3	NP_443137.2	Q96PY5	FMNL2_HUMAN	formin-like 2	976	FH2.				actin cytoskeleton organization	cytoplasm	actin binding|Rho GTPase binding			central_nervous_system(2)|endometrium(3)|large_intestine(5)|liver(2)|lung(3)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	23						GTCTTTGTCCGGTTTGTGAAA	0.438000													7	57					0	0	1	0	0
ESYT2	57488	broad.mit.edu	37	7	158552833	158552833	+	Silent	SNP	G	G	A			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr7:158552833G>A	ENST00000251527.5	-	12	1448	c.1383C>T	c.(1381-1383)ttC>ttT	p.F461F		NM_020728.2	NP_065779.1	A0FGR8	ESYT2_HUMAN	extended synaptotagmin-like protein 2	489	C2 1.					integral to membrane|plasma membrane				breast(1)|central_nervous_system(2)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(7)|lung(16)|prostate(2)	32						CGTCCAGAGTGAACCACTGAA	0.438000													5	90					0	0	1	0	0
ZNF285	26974	broad.mit.edu	37	19	44891920	44891920	+	Nonsense_Mutation	SNP	G	G	A			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr19:44891920G>A	ENST00000330997.4	-	4	551	c.487C>T	c.(487-489)Cag>Tag	p.Q163*	CTC-512J12.6_ENST00000588212.1_Intron|ZNF285_ENST00000544719.2_Nonsense_Mutation_p.Q163*|ZNF285_ENST00000591679.1_Nonsense_Mutation_p.Q170*	NM_152354.3	NP_689567.3			zinc finger protein 285											breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(15)|ovary(2)|prostate(5)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	44						TATCTTCCCTGAGAGTTCTGG	0.453000													14	235					0	0	1	0	0
PLXNB2	23654	broad.mit.edu	37	22	50722576	50722576	+	Missense_Mutation	SNP	C	C	T			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr22:50722576C>T	ENST00000449103.1	-	13	2388	c.2248G>A	c.(2248-2250)Gac>Aac	p.D750N	PLXNB2_ENST00000496720.1_5'UTR|PLXNB2_ENST00000359337.4_Missense_Mutation_p.D750N			O15031	PLXB2_HUMAN	plexin B2	750					regulation of small GTPase mediated signal transduction	integral to membrane|intracellular	GTPase activator activity|protein binding|receptor activity			breast(2)|central_nervous_system(4)|cervix(2)|endometrium(11)|kidney(4)|large_intestine(3)|liver(1)|lung(20)|ovary(5)|prostate(6)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	66		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		AGCTTGCTGTCGATATTCTTG	0.682000													28	64					0	0	1	0	0
F9	2158	broad.mit.edu	37	X	138643976	138643976	+	Missense_Mutation	SNP	G	G	A			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chrX:138643976G>A	ENST00000218099.2	+	8	1139	c.1132G>A	c.(1132-1134)Gac>Aac	p.D378N	F9_ENST00000394090.2_Missense_Mutation_p.D340N	NM_000133.3	NP_000124.1	P00740	FA9_HUMAN	coagulation factor IX	378	Peptidase S1.				blood coagulation, extrinsic pathway|blood coagulation, intrinsic pathway|peptidyl-glutamic acid carboxylation|post-translational protein modification|proteolysis	endoplasmic reticulum lumen|extracellular region|Golgi lumen|plasma membrane	calcium ion binding|serine-type endopeptidase activity			breast(1)|central_nervous_system(2)|endometrium(4)|large_intestine(7)|lung(19)|ovary(1)|skin(1)	35	Acute lymphoblastic leukemia(192;0.000127)				Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Heparin(DB01109)|Menadione(DB00170)	TCCACTTGTTGACCGAGCCAC	0.443000													8	54					0	0	1	0	0
POTEC	388468	broad.mit.edu	37	18	14542841	14542841	+	Missense_Mutation	SNP	C	C	A			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr18:14542841C>A	ENST00000358970.5	-	1	304	c.305G>T	c.(304-306)tGc>tTc	p.C102F	POTEC_ENST00000389891.4_5'UTR	NM_001137671.1	NP_001131143.1	B2RU33	POTEC_HUMAN	POTE ankyrin domain family, member C	102										NS(2)|breast(1)|endometrium(9)|kidney(13)|lung(14)|prostate(3)|skin(6)|soft_tissue(1)|urinary_tract(3)	52						GCAGTGACAGCACCACTTGCC	0.617000													57	271					1.4709e-25	1.69054e-25	1	1	0
NRXN1	9378	broad.mit.edu	37	2	50850745	50850745	+	Nonsense_Mutation	SNP	C	C	A			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr2:50850745C>A	ENST00000404971.1	-	7	2279	c.940G>T	c.(940-942)Gaa>Taa	p.E314*	NRXN1_ENST00000402717.3_Nonsense_Mutation_p.E281*|NRXN1_ENST00000406859.3_Nonsense_Mutation_p.E281*|NRXN1_ENST00000406316.2_Nonsense_Mutation_p.E281*|NRXN1_ENST00000331040.5_5'UTR|NRXN1_ENST00000401669.2_Nonsense_Mutation_p.E281*|NRXN1_ENST00000405472.3_Nonsense_Mutation_p.E281*	NM_001135659.1	NP_001129131.1	Q9ULB1	NRX1A_HUMAN	neurexin 1	281	Laminin G-like 2.				adult behavior|axon guidance|cell adhesion|grooming behavior|learning|neuromuscular process controlling balance|positive regulation of excitatory postsynaptic membrane potential|prepulse inhibition	cell surface|integral to plasma membrane	metal ion binding|protein binding|receptor activity			breast(1)|endometrium(3)|kidney(3)|large_intestine(10)|lung(33)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	58		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.192)	Lung(47;0.0813)|LUSC - Lung squamous cell carcinoma(58;0.116)			GCAATATATTCTTCTTTTCCT	0.358000													15	35					1.49906e-05	1.61339e-05	1	1	0
ANK3	288	broad.mit.edu	37	10	61898790	61898790	+	Silent	SNP	C	C	T			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr10:61898790C>T	ENST00000280772.1	-	24	2861	c.2670G>A	c.(2668-2670)aaG>aaA	p.K890K	ANK3_ENST00000503366.1_Silent_p.K891K|ANK3_ENST00000373827.2_Silent_p.K884K|ANK3_ENST00000460468.1_Silent_p.K54K|ANK3_ENST00000355288.2_Silent_p.K24K	NM_020987.3	NP_066267.2	Q12955	ANK3_HUMAN	ankyrin 3, node of Ranvier (ankyrin G)	890					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						CACCCAATTCCTTAAGGTCCT	0.483000													35	110					0	0	1	0	0
NCAPD3	23310	broad.mit.edu	37	11	134027841	134027841	+	Missense_Mutation	SNP	C	C	T			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr11:134027841C>T	ENST00000534548.2	-	31	4220	c.4156G>A	c.(4156-4158)Gaa>Aaa	p.E1386K		NM_015261.2	NP_056076.1	P42695	CNDD3_HUMAN	non-SMC condensin II complex, subunit D3	1386					cell division|mitotic chromosome condensation	nuclear centromeric heterochromatin|nuclear condensin complex	methylated histone residue binding			NS(1)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(10)|kidney(5)|large_intestine(9)|liver(1)|lung(28)|ovary(3)|prostate(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	71	all_hematologic(175;0.127)	all_cancers(12;1.68e-21)|all_epithelial(12;5.86e-16)|all_lung(97;1.19e-05)|Lung NSC(97;2.76e-05)|Breast(109;0.000182)|Medulloblastoma(222;0.0245)|all_neural(223;0.0505)|Esophageal squamous(93;0.0559)		Epithelial(10;8.74e-10)|BRCA - Breast invasive adenocarcinoma(10;1e-08)|all cancers(11;1.46e-08)|OV - Ovarian serous cystadenocarcinoma(99;0.00345)|Lung(977;0.227)		CACGTTTTTTCTGGGCTTCCA	0.443000													36	247					0	0	1	0	0
PCDHA9	9752	broad.mit.edu	37	5	140229355	140229355	+	Silent	SNP	T	T	G			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr5:140229355T>G	ENST00000378122.3	+	1	1999	c.1275T>G	c.(1273-1275)gtT>gtG	p.V425V	PCDHA5_ENST00000529619.1_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA9_ENST00000532602.1_Silent_p.V425V|PCDHA4_ENST00000512229.2_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA7_ENST00000525929.1_Intron	NM_014005.3	NP_054724.1														breast(1)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|lung(18)|ovary(4)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	59			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGCTGGTGGTTACCGCGCGGG	0.637000													7	199					0	0	1	0	0
SIDT1	54847	broad.mit.edu	37	3	113342480	113342480	+	Missense_Mutation	SNP	C	C	G			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr3:113342480C>G	ENST00000264852.4	+	23	2933	c.2207C>G	c.(2206-2208)tCt>tGt	p.S736C	SIDT1_ENST00000393830.3_Missense_Mutation_p.S741C|SIDT1_ENST00000463226.1_3'UTR	NM_017699.2	NP_060169.2	Q9NXL6	SIDT1_HUMAN	SID1 transmembrane family, member 1	736						integral to membrane				breast(1)|central_nervous_system(1)|endometrium(9)|kidney(1)|large_intestine(11)|liver(2)|lung(15)|ovary(3)|pancreas(3)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	50						CTCCGCAGCTCTGAAAAGGTC	0.642000													10	250					0	0	1	0	0
NINL	22981	broad.mit.edu	37	20	25472025	25472025	+	Nonsense_Mutation	SNP	C	C	A			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr20:25472025C>A	ENST00000278886.6	-	11	1520	c.1447G>T	c.(1447-1449)Gag>Tag	p.E483*	NINL_ENST00000422516.1_Nonsense_Mutation_p.E483*	NM_025176.4	NP_079452.3	Q9Y2I6	NINL_HUMAN	ninein-like	483					G2/M transition of mitotic cell cycle	cytosol|microtubule|microtubule organizing center	calcium ion binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(13)|lung(25)|ovary(2)|pancreas(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	57						AGGCCAGCCTCCTCAGCCTGC	0.701000													10	55					2.68362e-12	3.02951e-12	1	1	0
STX17	55014	broad.mit.edu	37	9	102713369	102713369	+	Missense_Mutation	SNP	G	G	C			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr9:102713369G>C	ENST00000259400.6	+	4	353	c.217G>C	c.(217-219)Gag>Cag	p.E73Q	STX17_ENST00000534052.1_Missense_Mutation_p.E73Q|STX17_ENST00000525847.1_3'UTR|STX17_ENST00000525640.1_Missense_Mutation_p.E73Q	NM_017919.2	NP_060389.2	P56962	STX17_HUMAN	syntaxin 17	73					intracellular protein transport|vesicle-mediated transport	endoplasmic reticulum|integral to membrane|nucleolus	SNAP receptor activity			endometrium(2)|large_intestine(2)|lung(2)|upper_aerodigestive_tract(1)	7		Acute lymphoblastic leukemia(62;0.0559)|all_hematologic(171;0.189)				CCGAGAAATTGAGAAACTTTG	0.333000													16	55					0	0	1	0	0
DHRS9	10170	broad.mit.edu	37	2	169952187	169952187	+	Silent	SNP	C	C	T			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr2:169952187C>T	ENST00000327239.4	+	8	2374	c.870C>T	c.(868-870)ttC>ttT	p.F290F	DHRS9_ENST00000602501.1_Silent_p.F290F|DHRS9_ENST00000357546.2_Silent_p.F290F|DHRS9_ENST00000428522.1_Silent_p.F290F|DHRS9_ENST00000421653.1_Silent_p.F143F|DHRS9_ENST00000436483.2_Silent_p.F290F|DHRS9_ENST00000432060.2_Silent_p.F350F|DHRS9_ENST00000412271.1_Silent_p.F290F	NM_005771.4	NP_005762.2	Q9BPW9	DHRS9_HUMAN	dehydrogenase/reductase (SDR family) member 9	290					9-cis-retinoic acid biosynthetic process|androgen metabolic process|epithelial cell differentiation|progesterone metabolic process|retinol metabolic process	integral to endoplasmic reticulum membrane|microsome	alcohol dehydrogenase (NAD) activity|binding|racemase and epimerase activity|retinol dehydrogenase activity|testosterone dehydrogenase (NAD+) activity			breast(1)|endometrium(3)|large_intestine(2)|lung(5)|skin(1)|upper_aerodigestive_tract(1)	13						CCAAAATTTTCTGGATACCTC	0.468000													8	173					0	0	1	0	0
EVC	2121	broad.mit.edu	37	4	5785373	5785373	+	Missense_Mutation	SNP	A	A	T	rs140567069		TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr4:5785373A>T	ENST00000382674.2	+	12	1842	c.1658A>T	c.(1657-1659)gAg>gTg	p.E553V	EVC_ENST00000264956.6_Missense_Mutation_p.E553V			P57679	EVC_HUMAN	Ellis van Creveld syndrome	553					muscle organ development	integral to membrane				NS(1)|breast(1)|endometrium(2)|large_intestine(10)|lung(11)|ovary(1)|skin(1)|stomach(1)	28		Myeloproliferative disorder(84;0.117)				CCCCCGGAAGAGTGTGACTAC	0.587000													9	48					0	0	1	0	0
IKBIP	121457	broad.mit.edu	37	12	99019911	99019911	+	Missense_Mutation	SNP	T	T	A			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr12:99019911T>A	ENST00000299157.4	-	3	1304	c.931A>T	c.(931-933)Atg>Ttg	p.M311L	IKBIP_ENST00000420861.1_Intron|IKBIP_ENST00000393042.3_Intron|IKBIP_ENST00000342502.2_Intron	NM_153687.3	NP_710154.1	Q70UQ0	IKIP_HUMAN	IKBKB interacting protein	312					induction of apoptosis|response to X-ray	endoplasmic reticulum membrane|integral to membrane	protein binding			NS(1)|kidney(1)|large_intestine(1)|lung(1)|prostate(2)	6						GCTTTCAGCATATCATCTTCC	0.348000													22	59					0	0	1	0	0
ADAM9	8754	broad.mit.edu	37	8	38871556	38871556	+	Silent	SNP	T	T	C			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr8:38871556T>C	ENST00000487273.2	+	4	405	c.327T>C	c.(325-327)aaT>aaC	p.N109N	ADAM9_ENST00000481513.1_Silent_p.N109N|ADAM9_ENST00000466936.1_Silent_p.N109N	NM_003816.2	NP_003807.1	Q13443	ADAM9_HUMAN	ADAM metallopeptidase domain 9	109				Missing (in Ref. 2; no nucleotide entry).	activation of MAPKK activity|cell-cell adhesion mediated by integrin|cell-matrix adhesion|keratinocyte differentiation|monocyte activation|PMA-inducible membrane protein ectodomain proteolysis|positive regulation of cell adhesion mediated by integrin|positive regulation of keratinocyte migration|positive regulation of macrophage fusion|positive regulation of membrane protein ectodomain proteolysis|positive regulation of protein secretion|response to calcium ion|response to glucocorticoid stimulus|response to hydrogen peroxide|response to manganese ion|response to tumor necrosis factor|transforming growth factor beta receptor signaling pathway	extracellular space|integral to membrane|intrinsic to external side of plasma membrane	collagen binding|integrin binding|laminin binding|metalloendopeptidase activity|protein kinase C binding|SH3 domain binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(5)|lung(14)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	31		all_lung(54;0.00292)|Lung NSC(58;0.0115)|Hepatocellular(245;0.0153)	LUSC - Lung squamous cell carcinoma(45;2.74e-07)			ACCATCCCAATATACAGGTAA	0.328000													14	160					0	0	1	0	0
SEC23A	10484	broad.mit.edu	37	14	39508284	39508284	+	Nonsense_Mutation	SNP	G	G	C			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr14:39508284G>C	ENST00000537403.1	-	15	2755	c.1553C>G	c.(1552-1554)tCa>tGa	p.S518*	SEC23A_ENST00000545328.2_Nonsense_Mutation_p.S691*|SEC23A_ENST00000536508.1_Nonsense_Mutation_p.S618*|SEC23A_ENST00000307712.6_Nonsense_Mutation_p.S720*			Q15436	SC23A_HUMAN	Sec23 homolog A (S. cerevisiae)	720					COPII vesicle coating|intracellular protein transport|post-translational protein modification|protein N-linked glycosylation via asparagine	COPII vesicle coat|cytosol|Golgi membrane|smooth endoplasmic reticulum membrane	protein binding|zinc ion binding			kidney(2)|large_intestine(3)|liver(1)|lung(11)|ovary(4)|pancreas(1)|upper_aerodigestive_tract(1)	23	Hepatocellular(127;0.213)		Lung(238;0.00047)|LUAD - Lung adenocarcinoma(48;0.000565)	GBM - Glioblastoma multiforme(112;0.0151)		GTTGACTTTTGAAAGGAGGAA	0.328000													10	147					0	0	1	0	0
PDIA3	2923	broad.mit.edu	37	15	44053674	44053674	+	Silent	SNP	C	C	G			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr15:44053674C>G	ENST00000300289.5	+	4	565	c.417C>G	c.(415-417)ctC>ctG	p.L139L	PDIA3_ENST00000538521.1_Silent_p.L119L	NM_005313.4	NP_005304.3	P30101	PDIA3_HUMAN	protein disulfide isomerase family A, member 3	139					cell redox homeostasis|glycerol ether metabolic process|post-translational protein modification|protein folding|protein import into nucleus|protein N-linked glycosylation via asparagine|protein retention in ER lumen|signal transduction	endoplasmic reticulum lumen|melanosome	cysteine-type endopeptidase activity|electron carrier activity|phospholipase C activity|protein binding|protein disulfide isomerase activity|protein disulfide oxidoreductase activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(9)|ovary(2)|skin(1)	17		all_cancers(109;2.61e-15)|all_epithelial(112;1.12e-12)|Lung NSC(122;2.17e-08)|all_lung(180;2.45e-07)|Melanoma(134;0.027)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;9.48e-07)		CAGTGCCTCTCAGGACTGAGG	0.363000													3	63					0	0	1	0	0
ZNF134	7693	broad.mit.edu	37	19	58131949	58131949	+	Missense_Mutation	SNP	C	C	A			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr19:58131949C>A	ENST00000396161.5	+	3	772	c.462C>A	c.(460-462)caC>caA	p.H154Q		NM_003435.3	NP_003426.3	P52741	ZN134_HUMAN	zinc finger protein 134	154						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(3)|lung(3)|prostate(1)	11		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0265)		AGGCCATCCACAGTAAGAGGA	0.483000													10	46					0.0692343	0.0700618	1	1	0
BZRAP1	9256	broad.mit.edu	37	17	56388367	56388367	+	Missense_Mutation	SNP	C	C	G			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr17:56388367C>G	ENST00000355701.3	-	19	4159	c.3289G>C	c.(3289-3291)Gag>Cag	p.E1097Q	BZRAP1_ENST00000343736.4_Missense_Mutation_p.E1097Q|BZRAP1_ENST00000268893.6_Missense_Mutation_p.E1037Q	NM_001261835.1|NM_004758.3	NP_001248764.1|NP_004749.2	O95153	RIMB1_HUMAN	benzodiazapine receptor (peripheral) associated protein 1	1097	Pro-rich.					mitochondrion	benzodiazepine receptor binding			cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|liver(2)|lung(16)|ovary(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	54	Medulloblastoma(34;0.127)|all_neural(34;0.237)					GCTCTGGCCTCTGGGCTTGGG	0.701000													7	9					0	0	1	0	0
ZNF549	256051	broad.mit.edu	37	19	58049430	58049430	+	Missense_Mutation	SNP	G	G	A			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr19:58049430G>A	ENST00000376233.3	+	4	1239	c.1058G>A	c.(1057-1059)aGa>aAa	p.R353K	ZNF549_ENST00000602149.1_Intron|ZNF550_ENST00000601415.1_Intron|ZNF549_ENST00000594943.1_Intron|ZNF549_ENST00000240719.3_Missense_Mutation_p.R340K	NM_001199295.1	NP_001186224.1	Q6P9A3	ZN549_HUMAN	zinc finger protein 549	353					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(3)|endometrium(1)|kidney(1)|large_intestine(8)|lung(3)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	21		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.221)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		CATCAGCAGAGAATCCACACT	0.443000													6	136					0	0	1	0	0
SEMA3C	10512	broad.mit.edu	37	7	80447685	80447685	+	Missense_Mutation	SNP	T	T	C			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr7:80447685T>C	ENST00000265361.3	-	5	938	c.377A>G	c.(376-378)cAt>cGt	p.H126R	SEMA3C_ENST00000536800.1_Intron|SEMA3C_ENST00000544525.1_Missense_Mutation_p.H144R|SEMA3C_ENST00000419255.2_Missense_Mutation_p.H126R	NM_006379.3	NP_006370.1	Q99985	SEM3C_HUMAN	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C	126	Sema.				immune response|response to drug	membrane	receptor activity			NS(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(17)|ovary(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	34						GACATACAAATGTGTGCGATT	0.388000													5	96					0	0	1	0	0
UBXN6	80700	broad.mit.edu	37	19	4445519	4445519	+	Silent	SNP	C	C	A			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr19:4445519C>A	ENST00000301281.6	-	11	1426	c.1302G>T	c.(1300-1302)ctG>ctT	p.L434L	UBXN6_ENST00000394765.3_Silent_p.L381L	NM_025241.2	NP_079517.1	Q9BZV1	UBXN6_HUMAN	UBX domain protein 6	434						microtubule organizing center|nucleus	protein binding			NS(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(4)|skin(1)	12						CGATGGCTGACAGGAGCTCGG	0.627000													8	175					0.0477658	0.04853	1	1	0
OSBP2	23762	broad.mit.edu	37	22	31302302	31302302	+	Nonsense_Mutation	SNP	G	G	A			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr22:31302302G>A	ENST00000332585.6	+	14	2831	c.2727G>A	c.(2725-2727)tgG>tgA	p.W909*	OSBP2_ENST00000401475.1_Nonsense_Mutation_p.W542*|OSBP2_ENST00000437268.2_Nonsense_Mutation_p.W652*|OSBP2_ENST00000446658.2_Nonsense_Mutation_p.W908*|OSBP2_ENST00000403222.3_Nonsense_Mutation_p.W743*|OSBP2_ENST00000382310.3_3'UTR|OSBP2_ENST00000535268.1_Nonsense_Mutation_p.W453*|OSBP2_ENST00000407373.1_Nonsense_Mutation_p.W736*	NM_030758.3	NP_110385.1	Q969R2	OSBP2_HUMAN	oxysterol binding protein 2	909					lipid transport	membrane	lipid binding			breast(3)|central_nervous_system(1)|endometrium(2)|kidney(2)|lung(6)|ovary(1)|skin(3)|urinary_tract(1)	19						AGCAAGACTGGCATATGTGCC	0.557000													4	128					0	0	1	0	0
CEP350	9857	broad.mit.edu	37	1	180022217	180022217	+	Silent	SNP	A	A	G			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr1:180022217A>G	ENST00000367607.3	+	23	5323	c.4905A>G	c.(4903-4905)agA>agG	p.R1635R		NM_014810.4	NP_055625.4	Q5VT06	CE350_HUMAN	centrosomal protein 350kDa	1635						centrosome|nucleus|spindle				central_nervous_system(1)|endometrium(9)|kidney(4)|large_intestine(7)|lung(35)|ovary(4)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	66						GTCACCGCAGATTTAACATGG	0.368000													13	79					0	0	1	0	0
OR2J3	442186	broad.mit.edu	37	6	29080141	29080141	+	Missense_Mutation	SNP	C	C	G			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr6:29080141C>G	ENST00000377169.1	+	1	474	c.474C>G	c.(472-474)aaC>aaG	p.N158K		NM_001005216.2	NP_001005216.2	O76001	OR2J3_HUMAN	olfactory receptor, family 2, subfamily J, member 3	158					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|large_intestine(5)|lung(13)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	24						GTTTTACCAACTCAGCACTTC	0.493000													10	207					0	0	1	0	0
INO80D	54891	broad.mit.edu	37	2	206869117	206869117	+	Missense_Mutation	SNP	G	G	C			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr2:206869117G>C	ENST00000403263.1	-	11	3463	c.3059C>G	c.(3058-3060)tCt>tGt	p.S1020C		NM_017759.4	NP_060229.3	Q53TQ3	IN80D_HUMAN	INO80 complex subunit D	0					DNA recombination|DNA repair|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				NS(1)|cervix(2)|endometrium(3)|kidney(3)|large_intestine(3)|lung(9)|ovary(2)|prostate(1)|urinary_tract(2)	26						AAAGGGAGAAGATGCATTATT	0.522000													4	10					0	0	1	0	0
PEX5L	51555	broad.mit.edu	37	3	179592146	179592146	+	Missense_Mutation	SNP	G	G	A			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr3:179592146G>A	ENST00000467460.1	-	7	1025	c.695C>T	c.(694-696)gCt>gTt	p.A232V	PEX5L_ENST00000472994.1_Missense_Mutation_p.A173V|PEX5L_ENST00000468741.1_Missense_Mutation_p.A40V|PEX5L_ENST00000467440.2_5'UTR|PEX5L_ENST00000465751.1_Missense_Mutation_p.A208V|PEX5L_ENST00000464614.1_Missense_Mutation_p.A124V|PEX5L_ENST00000392649.3_Missense_Mutation_p.A124V|PEX5L_ENST00000263962.8_Missense_Mutation_p.A230V|PEX5L_ENST00000485199.1_Missense_Mutation_p.A197V|PEX5L_ENST00000476138.1_Missense_Mutation_p.A189V	NM_001256751.1|NM_016559.2	NP_001243680.1|NP_057643.1	Q8IYB4	PEX5R_HUMAN	peroxisomal biogenesis factor 5-like	232					protein import into peroxisome matrix|regulation of cAMP-mediated signaling	cytosol|peroxisomal membrane	peroxisome matrix targeting signal-1 binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(23)|ovary(3)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	49	all_cancers(143;3.94e-14)|Ovarian(172;0.0338)|Breast(254;0.183)		OV - Ovarian serous cystadenocarcinoma(80;1.75e-26)|GBM - Glioblastoma multiforme(14;0.000518)			CAATTCTGAAGCCGACTCAGA	0.393000													33	115					0	0	1	0	0
LRRC8D	55144	broad.mit.edu	37	1	90399031	90399031	+	Missense_Mutation	SNP	C	C	G			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr1:90399031C>G	ENST00000337338.5	+	3	811	c.404C>G	c.(403-405)aCa>aGa	p.T135R	LRRC8D_ENST00000394593.3_Missense_Mutation_p.T135R	NM_001134479.1	NP_001127951.1	Q7L1W4	LRC8D_HUMAN	leucine rich repeat containing 8 family, member D	135						integral to membrane	protein binding			breast(2)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(10)|lung(10)|ovary(2)|skin(1)	29		all_lung(203;0.0894)|Lung NSC(277;0.227)		all cancers(265;0.0109)|Epithelial(280;0.0427)		AAAGATCCAACAGGTCGAAAA	0.408000													5	71					0	0	1	0	0
C17orf70	80233	broad.mit.edu	37	17	79517412	79517412	+	Missense_Mutation	SNP	C	C	T			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr17:79517412C>T	ENST00000537152.1	-	3	1180	c.655G>A	c.(655-657)Gat>Aat	p.D219N	C17orf70_ENST00000327787.8_Missense_Mutation_p.D370N	NM_025161.5	NP_079437.5	Q0VG06	FP100_HUMAN	chromosome 17 open reading frame 70	370					DNA repair	cytoplasm|intermediate filament cytoskeleton|nucleoplasm	DNA binding			breast(1)|central_nervous_system(1)|endometrium(1)|lung(11)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	19	all_neural(118;0.0878)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0282)|OV - Ovarian serous cystadenocarcinoma(97;0.0371)			CGAGACAGATCCACCACACAG	0.692000													41	60					0	0	1	0	0
KCNJ12	3768	broad.mit.edu	37	17	21319683	21319683	+	Silent	SNP	G	G	A	rs111482429	byFrequency	TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr17:21319683G>A	ENST00000583088.1	+	3	1924	c.1029G>A	c.(1027-1029)tcG>tcA	p.S343S	KCNJ12_ENST00000331718.5_Silent_p.S343S	NM_021012.4	NP_066292.2			potassium inwardly-rectifying channel, subfamily J, member 12									p.S343S(2)		NS(1)|breast(4)|endometrium(4)|kidney(1)|large_intestine(5)|lung(39)|ovary(5)|skin(8)|stomach(3)	70				Colorectal(15;0.0183)|COAD - Colon adenocarcinoma(3;0.0732)		TTGACTACTCGCACTTCCACA	0.582000										Prostate(3;0.18)			29	237					0	0	1	0	0
ABCA12	26154	broad.mit.edu	37	2	215818734	215818734	+	Missense_Mutation	SNP	G	G	A			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr2:215818734G>A	ENST00000272895.7	-	44	6710	c.6491C>T	c.(6490-6492)tCg>tTg	p.S2164L	ABCA12_ENST00000389661.4_Missense_Mutation_p.S1846L|AC072062.1_ENST00000607412.1_RNA	NM_173076.2	NP_775099.2	Q86UK0	ABCAC_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 12	2164					cellular homeostasis|lipid transport	integral to membrane	ATP binding|ATPase activity			NS(3)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(45)|lung(44)|ovary(8)|pancreas(2)|prostate(4)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	139		Renal(323;0.127)		Epithelial(149;1.01e-05)|all cancers(144;0.00112)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.011)		GTCTAGGACCGACTGTTGTTG	0.398000													31	78					0	0	1	0	0
MARK4	57787	broad.mit.edu	37	19	45797632	45797632	+	Missense_Mutation	SNP	C	C	T			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr19:45797632C>T	ENST00000300843.4	+	14	1817	c.1520C>T	c.(1519-1521)aCc>aTc	p.T507I	MARK4_ENST00000262891.4_Missense_Mutation_p.T507I	NM_031417.3	NP_113605.2	Q96L34	MARK4_HUMAN	MAP/microtubule affinity-regulating kinase 4	507					microtubule bundle formation|nervous system development|positive regulation of programmed cell death	centrosome|neuron projection	ATP binding|gamma-tubulin binding|microtubule binding|protein serine/threonine kinase activity|tau-protein kinase activity|ubiquitin binding			NS(1)|biliary_tract(1)|central_nervous_system(4)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(6)|lung(7)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	31		all_neural(266;0.224)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.0102)		AGCATGATGACCCGCAGAAAC	0.587000													20	69					0	0	1	0	0
PCK1	5105	broad.mit.edu	37	20	56137247	56137247	+	Silent	SNP	C	C	T			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr20:56137247C>T	ENST00000319441.4	+	3	509	c.345C>T	c.(343-345)cgC>cgT	p.R115R	PCK1_ENST00000535860.1_Intron|PCK1_ENST00000543666.1_Intron	NM_002591.3	NP_002582.3	P35558	PCKGC_HUMAN	phosphoenolpyruvate carboxykinase 1 (soluble)	115					gluconeogenesis|glucose homeostasis|glycerol biosynthetic process from pyruvate|response to insulin stimulus	cytosol|nucleus	carboxylic acid binding|GTP binding|magnesium ion binding|manganese ion binding|phosphoenolpyruvate carboxykinase (GTP) activity			endometrium(2)|kidney(1)|large_intestine(4)|liver(2)|lung(19)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	34	Lung NSC(12;0.000764)|all_lung(29;0.00264)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(13;9.88e-12)|Epithelial(14;3.41e-08)|all cancers(14;2.13e-07)			AGCTCGGTCGCTGGATGTCAG	0.527000													7	54					0	0	1	0	0
WNK3	65267	broad.mit.edu	37	X	54276531	54276531	+	Missense_Mutation	SNP	C	C	A			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chrX:54276531C>A	ENST00000354646.2	-	16	3047	c.2609G>T	c.(2608-2610)cGg>cTg	p.R870L	WNK3_ENST00000375159.2_Missense_Mutation_p.R870L|WNK3_ENST00000375169.3_Missense_Mutation_p.R870L	NM_020922.4	NP_065973.2	Q9BYP7	WNK3_HUMAN	WNK lysine deficient protein kinase 3	870					intracellular protein kinase cascade|positive regulation of establishment of protein localization in plasma membrane|positive regulation of peptidyl-threonine phosphorylation|positive regulation of rubidium ion transmembrane transporter activity|positive regulation of rubidium ion transport|positive regulation of sodium ion transmembrane transporter activity|positive regulation of sodium ion transport|protein autophosphorylation	adherens junction|tight junction	ATP binding|protein binding|protein serine/threonine kinase activity|rubidium ion transmembrane transporter activity|sodium ion transmembrane transporter activity			autonomic_ganglia(1)|biliary_tract(1)|breast(4)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|lung(24)|ovary(4)|pancreas(2)|prostate(4)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	80						GAATCGCCACCGACCAACTGG	0.418000													6	7					0.217242	0.217242	1	1	0
ZFAT	57623	broad.mit.edu	37	8	135621016	135621016	+	Silent	SNP	G	G	A			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr8:135621016G>A	ENST00000520727.1	-	6	1004	c.705C>T	c.(703-705)taC>taT	p.Y235Y	ZFAT_ENST00000523399.1_Silent_p.Y185Y|ZFAT_ENST00000520214.1_Silent_p.Y235Y|ZFAT_ENST00000377838.3_Silent_p.Y247Y|ZFAT_ENST00000520356.1_Silent_p.Y235Y|ZFAT_ENST00000429442.2_Silent_p.Y235Y	NM_001029939.3	NP_001025110.2	Q9P243	ZFAT_HUMAN	zinc finger and AT hook domain containing	247					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nucleus	DNA binding|zinc ion binding			autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(10)|kidney(9)|large_intestine(8)|lung(16)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	54	all_epithelial(106;8.26e-19)|Lung NSC(106;3.47e-07)|all_lung(105;1.39e-06)|Ovarian(258;0.0102)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0432)			GCTGAATGGCGTATTCCTGGT	0.507000													44	119					0	0	1	0	0
IRAK1	3654	broad.mit.edu	37	X	153284056	153284056	+	Silent	SNP	C	C	T			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chrX:153284056C>T	ENST00000369980.3	-	5	890	c.723G>A	c.(721-723)ctG>ctA	p.L241L	IRAK1_ENST00000393687.2_Silent_p.L241L|IRAK1_ENST00000477274.1_5'UTR|IRAK1_ENST00000369974.2_Silent_p.L241L|IRAK1_ENST00000429936.2_Silent_p.L267L|IRAK1_ENST00000393682.1_Silent_p.L267L	NM_001025242.1|NM_001569.3	NP_001020413.1|NP_001560.2	P51617	IRAK1_HUMAN	interleukin-1 receptor-associated kinase 1	241	Protein kinase.				activation of MAPK activity|activation of NF-kappaB-inducing kinase activity|anti-apoptosis|innate immune response|interleukin-1-mediated signaling pathway|JNK cascade|lipopolysaccharide-mediated signaling pathway|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of NF-kappaB transcription factor activity|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of transcription, DNA-dependent|protein autophosphorylation|protein oligomerization|regulation of cytokine-mediated signaling pathway|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|transmembrane receptor protein serine/threonine kinase signaling pathway	cytosol|endosome membrane|interleukin-1 receptor complex	ATP binding|NF-kappaB-inducing kinase activity|protein binding|protein heterodimerization activity|protein homodimerization activity|ubiquitin-protein ligase activity			breast(1)|central_nervous_system(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(15)|ovary(2)	25	all_cancers(53;3.7e-16)|all_epithelial(53;3.44e-10)|all_lung(58;2.06e-07)|Lung NSC(58;2.72e-07)|all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					TCACCTCCTTCAGCCTCTTCA	0.602000													25	90					0	0	1	0	0
ZNF789	285989	broad.mit.edu	37	7	99084423	99084423	+	Missense_Mutation	SNP	G	G	C			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr7:99084423G>C	ENST00000331410.5	+	5	860	c.590G>C	c.(589-591)aGa>aCa	p.R197T	ZNF789_ENST00000493485.1_Intron|ZNF789_ENST00000448667.1_3'UTR|ZNF789_ENST00000494186.1_Intron	NM_213603.2	NP_998768.2	Q5FWF6	ZN789_HUMAN	zinc finger protein 789	197					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(2)|kidney(2)|large_intestine(4)|lung(2)|ovary(1)	11	all_cancers(62;2.54e-08)|all_epithelial(64;2.55e-09)|Lung NSC(181;0.0053)|all_lung(186;0.00895)|Esophageal squamous(72;0.0166)					ATTCTCACAAGAGCAAAGTCT	0.413000													15	182					0	0	1	0	0
MKRN1	23608	broad.mit.edu	37	7	140158912	140158912	+	Silent	SNP	G	G	A			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr7:140158912G>A	ENST00000255977.2	-	4	890	c.666C>T	c.(664-666)tgC>tgT	p.C222C	MKRN1_ENST00000443720.2_Silent_p.C222C|MKRN1_ENST00000474576.1_Silent_p.C158C|MKRN1_ENST00000437223.2_Intron|MKRN1_ENST00000480552.1_Intron	NM_013446.3	NP_038474.2	Q9UHC7	MKRN1_HUMAN	makorin ring finger protein 1	222							ligase activity|nucleic acid binding|protein binding|zinc ion binding			endometrium(1)|kidney(1)|large_intestine(3)|lung(9)|ovary(1)|skin(1)	16	Melanoma(164;0.00956)					CCCCGTATCGGCACTCTCCCA	0.557000													5	193					0	0	1	0	0
ATP11B	23200	broad.mit.edu	37	3	182602674	182602674	+	Frame_Shift_Del	DEL	T	T	-			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr3:182602674delT	ENST00000323116.5	+	22	2903	c.2643delT	c.(2641-2643)tafs	p.Y881fs		NM_014616.2	NP_055431.1	Q9Y2G3	AT11B_HUMAN	ATPase, class VI, type 11B	881					aminophospholipid transport|ATP biosynthetic process	integral to membrane|nuclear inner membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity	p.Y884fs*30(1)		breast(3)|cervix(2)|endometrium(2)|kidney(4)|large_intestine(6)|liver(2)|lung(14)|ovary(2)|pancreas(2)|prostate(1)|skin(2)|urinary_tract(1)	41	all_cancers(143;9.04e-15)|Ovarian(172;0.0355)		all cancers(12;1.2e-42)|Epithelial(37;2.77e-36)|LUSC - Lung squamous cell carcinoma(7;7.58e-24)|Lung(8;4.66e-22)|OV - Ovarian serous cystadenocarcinoma(80;2.35e-20)			TTGTACAGTATTTTTTTTATA	0.269													8	183	---	---	---	---					
OR2H1	26716	broad.mit.edu	37	6	29429951	29429951	+	Frame_Shift_Del	DEL	C	C	-			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr6:29429951delC	ENST00000377136.1	+	4	870	c.405delC	c.(403-405)cafs	p.H135fs	OR2H1_ENST00000396792.2_Frame_Shift_Del_p.H135fs|OR2H1_ENST00000442615.1_Frame_Shift_Del_p.H135fs|OR2H1_ENST00000377133.1_Frame_Shift_Del_p.H135fs|OR2H1_ENST00000377132.1_Frame_Shift_Del_p.H135fs|OR2H1_ENST00000473369.1_3'UTR			Q9GZK4	OR2H1_HUMAN	olfactory receptor, family 2, subfamily H, member 1	135					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(5)|lung(12)	17						CCATCATCCACCCCCGCCTGT	0.597													24	203	---	---	---	---					
EP400	57634	broad.mit.edu	37	12	132496061	132496063	+	In_Frame_Del	DEL	TTG	TTG	-			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr12:132496061_132496063delTTG	ENST00000333577.4	+	17	3540_3542	c.3431_3433delTTG	c.(3430-3435)ctt>c	p.LV1144del	EP400_ENST00000389562.2_In_Frame_Del_p.LV1107del|EP400_ENST00000332482.4_In_Frame_Del_p.LV1071del|EP400_ENST00000330386.6_In_Frame_Del_p.LV1108del|EP400_ENST00000389561.2_In_Frame_Del_p.LV1108del			Q96L91	EP400_HUMAN	E1A binding protein p400	1144	Helicase ATP-binding.|Interactions with RUVBL1 and RUVBL2.				histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nuclear speck	ATP binding|DNA binding|helicase activity	p.V1108L(1)		NS(1)|breast(6)|central_nervous_system(10)|cervix(1)|endometrium(21)|kidney(13)|large_intestine(25)|lung(56)|ovary(5)|prostate(8)|skin(6)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	161	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.198)		OV - Ovarian serous cystadenocarcinoma(86;3.01e-08)|Epithelial(86;3.43e-07)|all cancers(50;2.01e-06)		GGCCCCCATCTTGTTGTTGTGAG	0.453													9	132	---	---	---	---					
EDNRB	1910	broad.mit.edu	37	13	78475267	78475267	+	Frame_Shift_Del	DEL	A	A	-			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr13:78475267delA	ENST00000377211.4	-	5	1299	c.1147delT	c.(1147-1149)atfs	p.Y383fs	EDNRB_ENST00000334286.5_Frame_Shift_Del_p.Y293fs|EDNRB_ENST00000446573.1_Frame_Shift_Del_p.Y293fs	NM_001201397.1	NP_001188326.1	P24530	EDNRB_HUMAN	endothelin receptor type B	293			P -> L (in HSCR2; familial).		activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|enteric nervous system development|enteric smooth muscle cell differentiation|macrophage chemotaxis|negative regulation of adenylate cyclase activity|negative regulation of cellular protein metabolic process|negative regulation of neuron maturation|negative regulation of transcription from RNA polymerase II promoter|vein smooth muscle contraction	integral to plasma membrane	endothelin-B receptor activity|peptide hormone binding	p.Y293fs*3(1)		breast(2)|endometrium(2)|kidney(1)|large_intestine(18)|lung(16)|skin(3)	42		Acute lymphoblastic leukemia(28;0.0279)|Breast(118;0.037)		GBM - Glioblastoma multiforme(99;0.0933)	Bosentan(DB00559)	ATTAGTGTATAAAAAAATGCA	0.343													21	91	---	---	---	---					
TP53	7157	broad.mit.edu	37	17	7577531	7577532	+	Frame_Shift_Del	DEL	GG	GG	-			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr17:7577531_7577532delGG	ENST00000420246.2	-	7	881_882	c.749_750delCC	c.(748-750)cfs	p.P250fs	TP53_ENST00000455263.2_Frame_Shift_Del_p.P250fs|TP53_ENST00000359597.4_Frame_Shift_Del_p.P250fs|TP53_ENST00000413465.2_Frame_Shift_Del_p.P250fs|TP53_ENST00000269305.4_Frame_Shift_Del_p.P250fs|TP53_ENST00000445888.2_Frame_Shift_Del_p.P250fs	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	250	Interaction with AXIN1 (By similarity).|Interaction with HIPK1 (By similarity).		P -> A (in sporadic cancers; somatic mutation).|P -> F (in sporadic cancers; somatic mutation; requires 2 nucleotide substitutions).|P -> H (in sporadic cancers; somatic mutation).|P -> L (in sporadic cancers; somatic mutation).|P -> N (in sporadic cancers; somatic mutation; requires 2 nucleotide substitutions).|P -> Q (in sporadic cancers; somatic mutation).|P -> S (in sporadic cancers; somatic mutation).|P -> T (in sporadic cancers; somatic mutation).|RP -> SA (in a sporadic cancer; somatic mutation).|RP -> SS (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.P250L(45)|p.0?(8)|p.?(5)|p.P250H(4)|p.P250P(4)|p.P250F(3)|p.P250N(2)|p.M246_P250delMNRRP(2)|p.P250Q(2)|p.P250_L252delPIL(2)|p.P250_I251insXXXXXX(1)|p.N247_P250delNRRP(1)|p.P250_T253delPILT(1)|p.R249_I251delRPI(1)|p.R248_P250delRRP(1)|p.I251fs*13(1)|p.P250_I251insXXXXXXX(1)|p.I251fs*96(1)|p.R249_T256delRPILTIIT(1)|p.I251fs*94(1)|p.R249_P250delRP(1)|p.P250_I251insX(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		TGGTGAGGATGGGCCTCCGGTT	0.574		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			51	53	---	---	---	---					
TP53	7157	broad.mit.edu	37	17	7578250	7578250	+	Frame_Shift_Del	DEL	T	T	-			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr17:7578250delT	ENST00000420246.2	-	6	731	c.599delA	c.(598-600)atfs	p.N200fs	TP53_ENST00000574684.1_Intron|TP53_ENST00000455263.2_Frame_Shift_Del_p.N200fs|TP53_ENST00000359597.4_Frame_Shift_Del_p.N200fs|TP53_ENST00000413465.2_Frame_Shift_Del_p.N200fs|TP53_ENST00000269305.4_Frame_Shift_Del_p.N200fs|TP53_ENST00000445888.2_Frame_Shift_Del_p.N200fs	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	200	Interaction with AXIN1 (By similarity).|Interaction with HIPK1 (By similarity).|Required for interaction with FBXO42.		N -> D (in sporadic cancers; somatic mutation).|N -> I (in sporadic cancers; somatic mutation).|N -> K (in a sporadic cancer; somatic mutation).|N -> P (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|N -> S (in sporadic cancers; somatic mutation).|N -> T (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.0?(8)|p.?(5)|p.N200fs*47(2)|p.N200I(2)|p.N200S(2)|p.E198_L201>V(1)|p.N200fs*4(1)|p.E198fs*7(1)|p.N200fs*9(1)|p.N200fs*8(1)|p.P191fs*6(1)|p.N200T(1)|p.G199fs*42(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CACACGCAAATTTCCTTCCAC	0.547		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			18	94	---	---	---	---					
ZNF750	79755	broad.mit.edu	37	17	80789951	80789951	+	Frame_Shift_Del	DEL	C	C	-			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr17:80789951delC	ENST00000269394.3	-	2	1213	c.380delG	c.(379-381)gafs	p.G127fs	TBCD_ENST00000355528.4_Intron|TBCD_ENST00000539345.2_Intron|ZNF750_ENST00000572562.1_Intron|TBCD_ENST00000397466.2_Intron	NM_024702.2	NP_078978.2	Q32MQ0	ZN750_HUMAN	zinc finger protein 750	127						intracellular	zinc ion binding			NS(3)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|large_intestine(4)|lung(12)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	31	Breast(20;0.000523)|all_neural(118;0.0779)	all_cancers(8;0.0514)|all_epithelial(8;0.0748)	OV - Ovarian serous cystadenocarcinoma(97;0.0868)|BRCA - Breast invasive adenocarcinoma(99;0.149)			TGGCTTCTGTCCCAGGCACCT	0.642													12	54	---	---	---	---					
LGALS16	148003	broad.mit.edu	37	19	40148570	40148570	+	Frame_Shift_Del	DEL	A	A	-			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr19:40148570delA	ENST00000392051.3	+	2	131	c.63delA	c.(61-63)atfs	p.I22fs		NM_001190441.1	NP_001177370.1	A8MUM7	A8MUM7_HUMAN	lectin, galactoside-binding, soluble, 16	22							sugar binding										CCTGCGTGATAATCAAAGGGA	0.483													29	108	---	---	---	---					
OR11H1	81061	broad.mit.edu	37	22	16449803	16449805	+	Translation_Start_Site	DEL	ATT	ATT	-			TCGA-MZ-A7D7-01A-21D-A34J-08	TCGA-MZ-A7D7-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	664738f6-61da-48fa-aa97-0f115384a71d	a4e20a0d-a705-4c7a-b83a-249ad1e46724	g.chr22:16449803_16449805delATT	ENST00000252835.4	-	0	0_2					NM_001005239.1	NP_001005239.1	Q8NG94	O11H1_HUMAN	olfactory receptor, family 11, subfamily H, member 1						sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(2)|large_intestine(3)|lung(4)|skin(1)	11	all_hematologic(4;0.00567)|Acute lymphoblastic leukemia(84;0.0977)	all_epithelial(15;0.208)		Kidney(3;0.00216)|KIRC - Kidney renal clear cell carcinoma(3;0.00244)|Lung(27;0.0724)|COAD - Colon adenocarcinoma(3;0.211)		CAAGGGACACATTATCAGTCAGG	0.340													9	57	---	---	---	---