Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
TAAR9	134860	broad.mit.edu	37	6	132859788	132859788	+	RNA	SNP	A	A	T			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr6:132859788A>T	ENST00000434551.1	+	0	360					NM_175057.3	NP_778227.3	Q96RI9	TAAR9_HUMAN	trace amine associated receptor 9 (gene/pseudogene)							plasma membrane	G-protein coupled receptor activity					Breast(56;0.112)			OV - Ovarian serous cystadenocarcinoma(155;0.0042)|GBM - Glioblastoma multiforme(226;0.00816)		TTGCTTCTTTATTTCATTTAT	0.403000													5	177					0	0	1	0	0
FSHR	2492	broad.mit.edu	37	2	49189874	49189874	+	Nonstop_Mutation	SNP	A	A	T			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr2:49189874A>T	ENST00000406846.2	-	10	2205	c.2086T>A	c.(2086-2088)Taa>Aaa	p.*696K	FSHR_ENST00000304421.4_Nonstop_Mutation_p.*670K|FSHR_ENST00000541117.1_Nonstop_Mutation_p.*432K|FSHR_ENST00000346173.3_Nonstop_Mutation_p.*634K	NM_000145.3	NP_000136.2	P23945	FSHR_HUMAN	follicle stimulating hormone receptor	0					female gamete generation|male gonad development|spermatogenesis	integral to membrane|plasma membrane	follicle-stimulating hormone receptor activity|protein binding			NS(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(10)|liver(1)|lung(45)|ovary(4)|pancreas(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	73		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.181)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)		Choriogonadotropin alfa(DB00097)|Follitropin beta(DB00066)|Menotropins(DB00032)|Urofollitropin(DB00094)	ATTGTGTTTTAGTTTTGGGCT	0.423000									Gonadal Dysgenesis, 46 XX				5	141					0	0	1	0	0
IGFBP5	3488	broad.mit.edu	37	2	217541537	217541537	+	Silent	SNP	T	T	C			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr2:217541537T>C	ENST00000233813.4	-	4	1505	c.756A>G	c.(754-756)ccA>ccG	p.P252P		NM_000599.3	NP_000590.1	P24593	IBP5_HUMAN	insulin-like growth factor binding protein 5	252	Thyroglobulin type-1.				negative regulation of insulin-like growth factor receptor signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of smooth muscle cell proliferation|negative regulation of translation|signal transduction		insulin-like growth factor I binding			endometrium(1)|large_intestine(3)|lung(1)	5		Renal(323;0.0822)		Epithelial(149;2.1e-06)|all cancers(144;0.000165)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		ACTCCATGCCTGGCAGCTTCA	0.607000													4	365					0	0	1	0	0
KIF5A	3798	broad.mit.edu	37	12	57957964	57957964	+	Missense_Mutation	SNP	C	C	G			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr12:57957964C>G	ENST00000455537.2	+	4	639	c.365C>G	c.(364-366)tCc>tGc	p.S122C	KIF5A_ENST00000286452.5_Intron	NM_004984.2	NP_004975.2	Q12840	KIF5A_HUMAN	kinesin family member 5A	122	Kinesin-motor.				blood coagulation|cell death|microtubule-based movement|synaptic transmission	cytosol|kinesin complex|membrane fraction|microtubule|perinuclear region of cytoplasm	ATP binding|microtubule motor activity			breast(2)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(11)|liver(1)|lung(32)|ovary(2)|prostate(2)|skin(2)	62						CACATCTACTCCATGGATGAG	0.517000													3	95					0	0	1	0	0
DNAH3	55567	broad.mit.edu	37	16	20990695	20990695	+	Missense_Mutation	SNP	C	C	T			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr16:20990695C>T	ENST00000261383.3	-	50	8032	c.8033G>A	c.(8032-8034)cGc>cAc	p.R2678H	DNAH3_ENST00000415178.1_3'UTR	NM_017539.1	NP_060009.1	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	2678	Stalk (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(3)|autonomic_ganglia(1)|breast(12)|central_nervous_system(3)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(42)|liver(2)|lung(57)|ovary(14)|pancreas(1)|prostate(7)|skin(11)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(6)	202				GBM - Glioblastoma multiforme(48;0.207)		TGTCAGGTAGCGGTTCCTCAT	0.512000													4	89					0	0	1	0	0
OR4A47	403253	broad.mit.edu	37	11	48511101	48511101	+	Missense_Mutation	SNP	A	A	T			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr11:48511101A>T	ENST00000446524.1	+	1	833	c.757A>T	c.(757-759)Att>Ttt	p.I253F		NM_001005512.2	NP_001005512.2	Q6IF82	O4A47_HUMAN	olfactory receptor, family 4, subfamily A, member 47	253					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(2)|endometrium(1)|kidney(1)|large_intestine(2)|lung(18)|ovary(1)|skin(1)|urinary_tract(2)	29						TGTTCCTTGTATTTTTATGTA	0.428000													6	649					0	0	1	0	0
CCDC91	55297	broad.mit.edu	37	12	28458580	28458580	+	Splice_Site	SNP	A	A	T			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr12:28458580A>T	ENST00000545336.1	+	7	528		c.e7-1		CCDC91_ENST00000539107.1_Splice_Site|CCDC91_ENST00000306172.5_Splice_Site|CCDC91_ENST00000381259.1_Splice_Site|CCDC91_ENST00000381256.1_Splice_Site|CCDC91_ENST00000540401.1_Splice_Site			Q7Z6B0	CCD91_HUMAN	coiled-coil domain containing 91						protein transport	Golgi apparatus|membrane				NS(1)|breast(3)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(8)|skin(1)	22	Acute lymphoblastic leukemia(23;0.00718)|all_hematologic(23;0.0113)|Lung SC(9;0.184)					GTTTTTCTTTAGTATCTGGAG	0.393000													7	359					0	0	1	0	0
SOS2	6655	broad.mit.edu	37	14	50626628	50626628	+	Missense_Mutation	SNP	T	T	C			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr14:50626628T>C	ENST00000216373.5	-	10	1647	c.1373A>G	c.(1372-1374)cAt>cGt	p.H458R	SOS2_ENST00000555794.1_5'UTR|SOS2_ENST00000543680.1_Missense_Mutation_p.H425R	NM_006939.2	NP_008870.2	Q07890	SOS2_HUMAN	son of sevenless homolog 2 (Drosophila)	458	PH.				apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	DNA binding|protein binding|Rho guanyl-nucleotide exchange factor activity			cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(13)|lung(16)|ovary(2)|skin(1)	39	all_epithelial(31;0.000822)|Breast(41;0.0065)					CAGAAAAATATGCCGTTCATG	0.388000													90	140					0	0	1	0	0
PKD1L2	114780	broad.mit.edu	37	16	81190482	81190482	+	RNA	SNP	G	G	A			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr16:81190482G>A	ENST00000533478.1	-	0	2162				PKD1L2_ENST00000525539.1_RNA	NM_001278425.1	NP_001265354.1	Q7Z442	PK1L2_HUMAN	polycystic kidney disease 1-like 2						neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity|sugar binding			breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(20)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	44						GATCCTGAGCGTCCTTCCTCC	0.547000													13	19					0	0	1	0	0
PTPDC1	138639	broad.mit.edu	37	9	96857602	96857602	+	Missense_Mutation	SNP	A	A	T			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr9:96857602A>T	ENST00000375360.3	+	6	798	c.458A>T	c.(457-459)tAc>tTc	p.Y153F	PTPDC1_ENST00000288976.3_Missense_Mutation_p.Y205F	NM_001253830.1|NM_177995.2	NP_001240759.1|NP_818931.1	A2A3K4	PTPC1_HUMAN	protein tyrosine phosphatase domain containing 1	153							protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			endometrium(1)|kidney(3)|large_intestine(7)|lung(14)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(1)	32						TTCCTAGTTTACTTCTACAAT	0.353000													4	155					0	0	1	0	0
SOAT1	6646	broad.mit.edu	37	1	179319429	179319429	+	Splice_Site	SNP	A	A	T			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr1:179319429A>T	ENST00000367619.3	+	14	1457		c.e14-1		SOAT1_ENST00000539888.1_Splice_Site|SOAT1_ENST00000535686.1_Splice_Site|SOAT1_ENST00000540564.1_Splice_Site	NM_003101.5	NP_003092.4	P35610	SOAT1_HUMAN	sterol O-acyltransferase 1						cholesterol efflux|cholesterol esterification|cholesterol homeostasis|cholesterol metabolic process|cholesterol storage|macrophage derived foam cell differentiation|positive regulation of amyloid precursor protein biosynthetic process|very-low-density lipoprotein particle assembly	endoplasmic reticulum membrane|integral to membrane|microsome	cholesterol binding|cholesterol O-acyltransferase activity|fatty-acyl-CoA binding			central_nervous_system(1)|endometrium(3)|large_intestine(1)|lung(10)|prostate(1)|skin(3)|stomach(1)	20					Ezetimibe(DB00973)|Hesperetin(DB01094)	CTTTTTCTTTAGTTTTTCTCC	0.333000													4	114					0	0	1	0	0
ZNF845	91664	broad.mit.edu	37	19	53856702	53856702	+	Missense_Mutation	SNP	G	G	A	rs150688663	by1000genomes	TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr19:53856702G>A	ENST00000458035.1	+	4	2891	c.2774G>A	c.(2773-2775)cGt>cAt	p.R925H	ZNF845_ENST00000595091.1_Missense_Mutation_p.R925H	NM_138374.1	NP_612383.1	Q96IR2	ZN845_HUMAN	zinc finger protein 845	925					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.R925H(3)		endometrium(2)|kidney(10)|lung(7)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|urinary_tract(2)	26						AAAACCTTCCGTCACAATTCA	0.363000													3	31					0	0	1	0	0
PRKAA2	5563	broad.mit.edu	37	1	57140052	57140052	+	Splice_Site	SNP	A	A	T			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr1:57140052A>T	ENST00000371244.4	+	2	160		c.e2-1			NM_006252.3	NP_006243.2	P54646	AAPK2_HUMAN	protein kinase, AMP-activated, alpha 2 catalytic subunit						carnitine shuttle|cell cycle arrest|cholesterol biosynthetic process|energy reserve metabolic process|fatty acid biosynthetic process|insulin receptor signaling pathway|regulation of fatty acid biosynthetic process|regulation of fatty acid oxidation	cytosol|nucleoplasm	ATP binding|metal ion binding			breast(6)|endometrium(1)|large_intestine(6)|lung(7)|ovary(1)|prostate(1)|stomach(1)	23						TCTTTTCTTTAGTTGGAGAAC	0.313000													7	108					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179429763	179429763	+	Silent	SNP	A	A	T			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr2:179429763A>T	ENST00000589042.1	-	326	81320	c.81096T>A	c.(81094-81096)atT>atA	p.I27032I	TTN-AS1_ENST00000590932.1_RNA|TTN-AS1_ENST00000586831.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN-AS1_ENST00000586707.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN_ENST00000460472.2_Silent_p.I17967I|TTN_ENST00000591111.1_Silent_p.I25391I|TTN-AS1_ENST00000591332.1_RNA|TTN-AS1_ENST00000438095.1_RNA|TTN-AS1_ENST00000592600.1_RNA|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000359218.5_Silent_p.I18092I|TTN_ENST00000342992.6_Silent_p.I24464I|TTN_ENST00000342175.6_Silent_p.I18159I|TTN-AS1_ENST00000456053.1_RNA|TTN-AS1_ENST00000590807.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	25391	Fibronectin type-III 97.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TGGTTATTTTAATTGTTGTTC	0.413000													4	147					0	0	1	0	0
OR4D1	26689	broad.mit.edu	37	17	56232613	56232613	+	Missense_Mutation	SNP	A	A	T			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr17:56232613A>T	ENST00000268912.5	+	1	120	c.99A>T	c.(97-99)ttA>ttT	p.L33F		NM_012374.1	NP_036506.1	Q15615	OR4D1_HUMAN	olfactory receptor, family 4, subfamily D, member 1	33					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			kidney(2)|large_intestine(4)|lung(4)|ovary(1)|stomach(1)|urinary_tract(1)	13						TGTTCCTGTTAGTCTATGTTA	0.458000													8	464					0	0	1	0	0
GPAM	57678	broad.mit.edu	37	10	113915654	113915654	+	Missense_Mutation	SNP	A	A	T			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr10:113915654A>T	ENST00000348367.4	-	20	2476	c.2279T>A	c.(2278-2280)aTa>aAa	p.I760K	GPAM_ENST00000423155.1_Missense_Mutation_p.I760K|GPAM_ENST00000369425.1_3'UTR			Q9HCL2	GPAT1_HUMAN	glycerol-3-phosphate acyltransferase, mitochondrial	760					phospholipid biosynthetic process|triglyceride biosynthetic process	integral to membrane|mitochondrial outer membrane	glycerol-3-phosphate O-acyltransferase activity			breast(2)|central_nervous_system(2)|endometrium(8)|kidney(2)|large_intestine(5)|lung(8)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	31				Epithelial(162;0.0306)|all cancers(201;0.123)		TGTTCTGGTTATTAGGTATTT	0.353000													4	102					0	0	1	0	0
IGSF5	150084	broad.mit.edu	37	21	41142841	41142841	+	Splice_Site	SNP	A	A	T			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr21:41142841A>T	ENST00000380588.4	+	4	521		c.e4-1		IGSF5_ENST00000479378.1_Splice_Site	NM_001080444.1	NP_001073913.1	Q9NSI5	IGSF5_HUMAN	immunoglobulin superfamily, member 5							integral to membrane|tight junction				breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(7)|skin(2)|stomach(1)	23		Prostate(19;5.35e-06)				TTTCTTCTTTAGTTATGGGAG	0.388000													4	132					0	0	1	0	0
RRBP1	6238	broad.mit.edu	37	20	17595443	17595443	+	Missense_Mutation	SNP	T	T	C			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr20:17595443T>C	ENST00000377813.1	-	24	4436	c.4133A>G	c.(4132-4134)cAg>cGg	p.Q1378R	RRBP1_ENST00000377807.2_Missense_Mutation_p.Q945R|RRBP1_ENST00000455029.2_Missense_Mutation_p.Q719R|RRBP1_ENST00000360807.4_Missense_Mutation_p.Q945R|RRBP1_ENST00000246043.4_Missense_Mutation_p.Q1378R|RRBP1_ENST00000468428.1_5'UTR			Q9P2E9	RRBP1_HUMAN	ribosome binding protein 1	1378					protein transport|translation|transmembrane transport	integral to endoplasmic reticulum membrane|ribosome	receptor activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(9)|ovary(2)|prostate(6)	28						CAGCTGCTCCTGGGTCGTCTT	0.582000													3	48					0	0	1	0	0
TBC1D8B	54885	broad.mit.edu	37	X	106109045	106109045	+	Missense_Mutation	SNP	A	A	T			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chrX:106109045A>T	ENST00000357242.5	+	16	2618	c.2444A>T	c.(2443-2445)tAt>tTt	p.Y815F	TBC1D8B_ENST00000276175.3_Missense_Mutation_p.Y809F	NM_017752.2	NP_060222.2	Q0IIM8	TBC8B_HUMAN	TBC1 domain family, member 8B (with GRAM domain)	815						intracellular	calcium ion binding|Rab GTPase activator activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(3)|kidney(5)|large_intestine(6)|liver(4)|lung(15)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	47						TTATCTTGTTATTGGTGTTTG	0.343000													5	142					0	0	1	0	0
TFIP11	24144	broad.mit.edu	37	22	26888109	26888109	+	Missense_Mutation	SNP	C	C	T			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr22:26888109C>T	ENST00000407690.1	-	15	2667	c.2384G>A	c.(2383-2385)cGa>cAa	p.R795Q	TFIP11_ENST00000407431.1_Missense_Mutation_p.R795Q|TFIP11_ENST00000407148.1_Missense_Mutation_p.R795Q|TFIP11_ENST00000405938.1_Missense_Mutation_p.R795Q	NM_012143.2	NP_036275.1	Q9UBB9	TFP11_HUMAN	tuftelin interacting protein 11	795					biomineral tissue development	catalytic step 2 spliceosome|cytoplasm|nuclear speck	DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(5)|kidney(2)|large_intestine(5)|liver(1)|lung(7)|prostate(2)|skin(1)|urinary_tract(1)	25						CCCTTCGTGTCGCTTCCCAAT	0.557000													4	80					0	0	1	0	0
PRSS16	10279	broad.mit.edu	37	6	27215757	27215757	+	Missense_Mutation	SNP	T	T	C			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr6:27215757T>C	ENST00000230582.3	+	2	182	c.167T>C	c.(166-168)cTc>cCc	p.L56P	PRSS16_ENST00000421826.2_Missense_Mutation_p.L56P	NM_005865.3	NP_005856.1	Q9NQE7	TSSP_HUMAN	protease, serine, 16 (thymus)	56					protein catabolic process|proteolysis	cytoplasmic membrane-bounded vesicle	serine-type peptidase activity			central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(5)|lung(9)|ovary(3)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	26						GCTGCAGCCCTCCCAAAAGTG	0.632000													3	118					0	0	1	0	0
CCDC11	220136	broad.mit.edu	37	18	47777146	47777146	+	Missense_Mutation	SNP	A	A	T			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr18:47777146A>T	ENST00000398545.4	-	5	1095	c.978T>A	c.(976-978)gaT>gaA	p.D326E		NM_145020.3	NP_659457.2	Q96M91	CCD11_HUMAN	coiled-coil domain containing 11	326										endometrium(1)|kidney(4)|large_intestine(6)|lung(6)|ovary(1)|pancreas(1)|skin(1)	20				STAD - Stomach adenocarcinoma(97;2.66e-05)|Colorectal(21;7.57e-05)|Lung(128;0.00932)|READ - Rectum adenocarcinoma(32;0.164)		GTTTCTTTTTATCTGCCTCTT	0.423000													9	568					0	0	1	0	0
SENP2	59343	broad.mit.edu	37	3	185324122	185324122	+	Missense_Mutation	SNP	A	A	T			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr3:185324122A>T	ENST00000296257.5	+	6	694	c.454A>T	c.(454-456)Act>Tct	p.T152S	SENP2_ENST00000465201.1_3'UTR|SENP2_ENST00000545472.1_Missense_Mutation_p.T142S|SENP2_ENST00000427465.2_5'UTR	NM_021627.2	NP_067640.2	Q9HC62	SENP2_HUMAN	SUMO1/sentrin/SMT3 specific peptidase 2	152					mRNA transport|protein desumoylation|protein transport|proteolysis|regulation of Wnt receptor signaling pathway|transmembrane transport|Wnt receptor signaling pathway	cytoplasm|nuclear membrane|nuclear pore	protein binding|SUMO-specific protease activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(5)|skin(3)	12	all_cancers(143;1.28e-10)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(80;1.31e-21)			GCTCAGTTTTACTTTGAACTC	0.413000													4	87					0	0	1	0	0
PSMD1	5707	broad.mit.edu	37	2	232035330	232035330	+	Silent	SNP	G	G	A			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr2:232035330G>A	ENST00000308696.6	+	24	2928	c.2766G>A	c.(2764-2766)gaG>gaA	p.E922E	PSMD1_ENST00000409643.1_Silent_p.E891E|PSMD1_ENST00000373635.4_Silent_p.E891E	NM_002807.3	NP_002798.2	Q99460	PSMD1_HUMAN	proteasome (prosome, macropain) 26S subunit, non-ATPase, 1	922					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|regulation of protein catabolic process|S phase of mitotic cell cycle|viral reproduction	proteasome regulatory particle	enzyme regulator activity|protein binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(10)|lung(10)|ovary(1)|prostate(1)|skin(4)	31		Ovarian(221;0.000626)|Medulloblastoma(418;0.0109)|Renal(207;0.0112)|Lung NSC(271;0.0538)|all_lung(227;0.0713)|all_hematologic(139;0.0748)|Acute lymphoblastic leukemia(138;0.167)		Epithelial(121;4e-26)|LUSC - Lung squamous cell carcinoma(224;0.0138)|Lung(119;0.0168)	Bortezomib(DB00188)	AAGACATTGAGGAGCTGGTGG	0.493000													3	104					0	0	1	0	0
RANBP2	5903	broad.mit.edu	37	2	109378555	109378555	+	Splice_Site	SNP	A	A	T			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr2:109378555A>T	ENST00000283195.6	+	19	2728		c.e19-1			NM_006267.4	NP_006258.3	P49792	RBP2_HUMAN	RAN binding protein 2						carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA transport|protein folding|protein import into nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear pore	peptidyl-prolyl cis-trans isomerase activity|Ran GTPase binding|zinc ion binding		RANBP2/ALK(34)	NS(1)|biliary_tract(1)|breast(3)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(21)|large_intestine(19)|lung(51)|pancreas(1)|prostate(8)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(1)	129						TTGTTTTTTTAGTTGCAACTA	0.333000													4	82					0	0	1	0	0
BOD1L1	259282	broad.mit.edu	37	4	13603058	13603058	+	Silent	SNP	C	C	T			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr4:13603058C>T	ENST00000040738.5	-	10	5601	c.5466G>A	c.(5464-5466)tcG>tcA	p.S1822S		NM_148894.2	NP_683692.2	Q8NFC6	BOD1L_HUMAN	biorientation of chromosomes in cell division 1-like 1	1822							DNA binding										CATTTTCTTCCGATTCAGAAC	0.488000													4	201					0	0	1	0	0
KIF21A	55605	broad.mit.edu	37	12	39757017	39757017	+	Splice_Site	SNP	T	T	A			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr12:39757017T>A	ENST00000395670.3	-	7	1323		c.e7-2		KIF21A_ENST00000544797.2_Splice_Site|KIF21A_ENST00000541463.2_Splice_Site|KIF21A_ENST00000361418.5_Splice_Site|KIF21A_ENST00000361961.3_Splice_Site			Q7Z4S6	KI21A_HUMAN	kinesin family member 21A						microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(14)|lung(41)|ovary(5)|pancreas(1)|prostate(1)|skin(4)|stomach(1)|urinary_tract(2)	86		Lung NSC(34;0.179)|all_lung(34;0.213)				AAGTGCCAACTAAAAGAAAGA	0.333000													5	147					0	0	1	0	0
MKI67	4288	broad.mit.edu	37	10	129907060	129907060	+	Missense_Mutation	SNP	A	A	T			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr10:129907060A>T	ENST00000368654.3	-	13	3419	c.3044T>A	c.(3043-3045)aTa>aAa	p.I1015K	MKI67_ENST00000368653.3_Missense_Mutation_p.I655K	NM_002417.4	NP_002408.3	P46013	KI67_HUMAN	marker of proliferation Ki-67	1015	16 X 122 AA approximate repeats.				cell proliferation	nucleolus	ATP binding|protein C-terminus binding			NS(2)|autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(5)|kidney(7)|large_intestine(30)|lung(64)|ovary(4)|pancreas(1)|prostate(4)|skin(2)|soft_tissue(1)|stomach(10)|upper_aerodigestive_tract(4)|urinary_tract(4)	159		all_epithelial(44;2.12e-05)|all_lung(145;0.00679)|Lung NSC(174;0.00998)|all_neural(114;0.0936)|Colorectal(57;0.14)|Breast(234;0.166)|Melanoma(40;0.203)				TGGGGTGTTTATTGGTTCTGG	0.483000													8	535					0	0	1	0	0
ARHGEF12	23365	broad.mit.edu	37	11	120331379	120331379	+	Splice_Site	SNP	A	A	T			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr11:120331379A>T	ENST00000397843.2	+	27	2693		c.e27-1		ARHGEF12_ENST00000532993.1_Splice_Site|ARHGEF12_ENST00000356641.3_Splice_Site	NM_015313.2	NP_056128.1	Q9NZN5	ARHGC_HUMAN	Rho guanine nucleotide exchange factor (GEF) 12						apoptosis|axon guidance|G-protein coupled receptor protein signaling pathway|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|membrane	G-protein-coupled receptor binding|GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			NS(1)|breast(5)|endometrium(6)|kidney(5)|large_intestine(13)|lung(23)|ovary(4)|pancreas(1)|prostate(1)|skin(2)	61		Breast(109;0.000813)|Medulloblastoma(222;0.0425)|Hepatocellular(160;0.0831)|all_hematologic(192;0.107)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.231)		TTTTATCTTTAGTTGGATTGA	0.323000			T	MLL	AML								6	174					0	0	1	0	0
ANO10	55129	broad.mit.edu	37	3	43642047	43642047	+	Silent	SNP	A	A	G			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr3:43642047A>G	ENST00000292246.3	-	3	336	c.166T>C	c.(166-168)Tta>Cta	p.L56L	ANO10_ENST00000350459.4_Silent_p.L56L|ANO10_ENST00000396091.3_Intron|ANO10_ENST00000451430.2_Intron|ANO10_ENST00000414522.2_Silent_p.L56L	NM_018075.3	NP_060545.3	Q9NW15	ANO10_HUMAN	anoctamin 10	56					cell death	chloride channel complex	chloride channel activity			NS(1)|breast(1)|endometrium(4)|kidney(2)|large_intestine(3)|lung(9)|ovary(3)|prostate(3)|skin(3)	29						TATTTATTTAACAATGGTCTA	0.318000													4	149					0	0	1	0	0
PDK3	5165	broad.mit.edu	37	X	24516944	24516944	+	Splice_Site	SNP	A	A	T			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chrX:24516944A>T	ENST00000441463.2	+	3	248		c.e3-1		PDK3_ENST00000379162.4_Splice_Site|PDK3_ENST00000493226.1_Splice_Site	NM_001142386.2	NP_001135858.1	Q15120	PDK3_HUMAN	pyruvate dehydrogenase kinase, isozyme 3						glucose metabolic process|peptidyl-histidine phosphorylation|pyruvate metabolic process|regulation of acetyl-CoA biosynthetic process from pyruvate	mitochondrial matrix	ATP binding|protein binding|pyruvate dehydrogenase (acetyl-transferring) kinase activity|two-component sensor activity			NS(1)|endometrium(5)|kidney(1)|large_intestine(1)|lung(12)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	23						TTTTCCTTTTAGGTATATGCA	0.383000													3	16					0	0	1	0	0
TRPM6	140803	broad.mit.edu	37	9	77376913	77376913	+	Splice_Site	SNP	A	A	T			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr9:77376913A>T	ENST00000451710.3	-	26	4910		c.e26+1		TRPM6_ENST00000360774.1_Splice_Site|TRPM6_ENST00000376871.3_Intron|TRPM6_ENST00000361255.3_Splice_Site|TRPM6_ENST00000449912.2_Splice_Site|TRPM6_ENST00000376864.4_Splice_Site|TRPM6_ENST00000376872.3_Intron			Q9BX84	TRPM6_HUMAN	transient receptor potential cation channel, subfamily M, member 6						response to toxin	integral to membrane	ATP binding|calcium channel activity|metal ion binding|protein binding|protein serine/threonine kinase activity			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(22)|liver(1)|lung(53)|ovary(1)|prostate(7)|skin(12)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	126						TTTATTCCTTACTTTTAATCT	0.343000													4	63					0	0	1	0	0
WDR65	149465	broad.mit.edu	37	1	43650987	43650987	+	Missense_Mutation	SNP	T	T	A			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr1:43650987T>A	ENST00000372492.4	+	5	1253	c.929T>A	c.(928-930)aTg>aAg	p.M310K	WDR65_ENST00000528956.1_Missense_Mutation_p.M310K	NM_001195831.2	NP_001182760.2	Q96MR6	WDR65_HUMAN	WD repeat domain 65	310										NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(7)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	23	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				TTTGAGAAGATGGAAGAAAAG	0.478000													5	142					0	0	1	0	0
CCDC18	343099	broad.mit.edu	37	1	93649533	93649533	+	Splice_Site	SNP	A	A	T			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr1:93649533A>T	ENST00000343253.7	+	3	636		c.e3-1		CCDC18_ENST00000334652.5_Splice_Site|CCDC18_ENST00000401026.3_Splice_Site|CCDC18_ENST00000338949.4_Splice_Site|CCDC18_ENST00000557479.1_Splice_Site			Q5T9S5	CCD18_HUMAN	coiled-coil domain containing 18											breast(5)|endometrium(3)|kidney(1)|large_intestine(6)|lung(19)|ovary(3)|pancreas(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	42		all_lung(203;0.00196)|Lung NSC(277;0.00903)|Melanoma(281;0.099)|all_neural(321;0.185)|Glioma(108;0.203)		all cancers(265;0.00166)|GBM - Glioblastoma multiforme(16;0.00551)|Epithelial(280;0.0967)		TTTTTTCTCTAGTGTTAGTCC	0.328000													7	153					0	0	1	0	0
GSTCD	79807	broad.mit.edu	37	4	106640215	106640215	+	Splice_Site	SNP	A	A	T			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr4:106640215A>T	ENST00000515279.1	+	3	646		c.e3-1		GSTCD_ENST00000507281.1_Splice_Site|GSTCD_ENST00000515255.1_Intron|GSTCD_ENST00000394730.3_Splice_Site|GSTCD_ENST00000394728.3_Splice_Site|GSTCD_ENST00000360505.5_Splice_Site			Q8NEC7	GSTCD_HUMAN	glutathione S-transferase, C-terminal domain containing							cytoplasm	rRNA methyltransferase activity			breast(2)|central_nervous_system(1)|endometrium(2)|large_intestine(5)|lung(2)|ovary(1)|skin(1)	14		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;3.15e-07)|READ - Rectum adenocarcinoma(30;0.139)		TTTGTTTTGTAGGTTAGTCAG	0.338000													6	114					0	0	1	0	0
FLG	2312	broad.mit.edu	37	1	152281389	152281389	+	Silent	SNP	C	C	T	rs138652718	byFrequency	TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr1:152281389C>T	ENST00000368799.1	-	3	6008	c.5973G>A	c.(5971-5973)gcG>gcA	p.A1991A	FLG-AS1_ENST00000420707.1_RNA|FLG-AS1_ENST00000593011.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	1991	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CATGGGATGACGCAGCCTGTC	0.572000									Ichthyosis				5	638					0	0	1	0	0
RUSC2	9853	broad.mit.edu	37	9	35547238	35547238	+	Silent	SNP	T	T	C			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr9:35547238T>C	ENST00000455600.1	+	2	1289	c.720T>C	c.(718-720)ccT>ccC	p.P240P		NM_001135999.1	NP_001129471.1	Q8N2Y8	RUSC2_HUMAN	RUN and SH3 domain containing 2	240						cytosol				NS(1)|breast(3)|endometrium(4)|kidney(1)|large_intestine(9)|lung(4)|ovary(2)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	32			Lung(28;0.000837)|LUSC - Lung squamous cell carcinoma(32;0.00109)|STAD - Stomach adenocarcinoma(86;0.194)			CAAGGAACCCTGGATGCTCCG	0.597000													3	104					0	0	1	0	0
MAP4	4134	broad.mit.edu	37	3	47958144	47958144	+	Silent	SNP	A	A	G			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr3:47958144A>G	ENST00000426837.2	-	8	1311	c.1224T>C	c.(1222-1224)gcT>gcC	p.A408A	MAP4_ENST00000360240.6_Silent_p.A391A|MAP4_ENST00000395734.3_Silent_p.A391A|MAP4_ENST00000383737.4_Intron			P27816	MAP4_HUMAN	microtubule-associated protein 4	391	17 X 14 AA tandem repeats.				negative regulation of microtubule depolymerization	cytoplasm|microtubule|microtubule associated complex	protein binding|structural molecule activity	p.A391A(2)		breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(10)|ovary(2)|pancreas(1)|skin(2)	32				BRCA - Breast invasive adenocarcinoma(193;0.000721)|KIRC - Kidney renal clear cell carcinoma(197;0.00641)|Kidney(197;0.00736)		CCTTGGAAGGAGCCAAGTCCA	0.443000													4	277					0	0	1	0	0
RALGPS2	55103	broad.mit.edu	37	1	178802557	178802557	+	Splice_Site	SNP	A	A	T			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr1:178802557A>T	ENST00000367635.3	+	8	818		c.e8-1		RALGPS2_ENST00000324778.4_Splice_Site|RALGPS2_ENST00000367634.2_Splice_Site	NM_152663.3	NP_689876.2	Q86X27	RGPS2_HUMAN	Ral GEF with PH domain and SH3 binding motif 2						small GTPase mediated signal transduction	cytoplasm|plasma membrane	guanyl-nucleotide exchange factor activity|protein binding			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(11)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	29						TTTGTTTTTTAGTTATTAAGT	0.259000													4	42					0	0	1	0	0
NFATC2	4773	broad.mit.edu	37	20	50007990	50007990	+	Splice_Site	SNP	T	T	A			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr20:50007990T>A	ENST00000371564.3	-	11	3030		c.e11-2		NFATC2_ENST00000414705.1_Splice_Site|NFATC2_ENST00000396009.3_Splice_Site	NM_001258296.1|NM_012340.4	NP_001245225.1|NP_036472.2	Q13469	NFAC2_HUMAN	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2						B cell receptor signaling pathway|positive regulation of B cell proliferation|response to DNA damage stimulus|response to drug	actin cytoskeleton|nucleus|plasma membrane	protein binding|sequence-specific DNA binding transcription factor activity		EWSR1/NFATC2(9)	breast(2)|endometrium(7)|kidney(1)|large_intestine(7)|lung(25)|ovary(2)|prostate(2)|skin(5)|stomach(1)|urinary_tract(1)	53	Hepatocellular(150;0.248)					TTTCATTAACTACAAAAGAAA	0.458000													5	182					0	0	1	0	0
CKAP2L	150468	broad.mit.edu	37	2	113500345	113500345	+	Splice_Site	SNP	G	G	A			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr2:113500345G>A	ENST00000541405.1	-	7	1788	c.1263_splice	c.e7-1	p.P422_splice	NT5DC4_ENST00000327581.4_3'UTR|CKAP2L_ENST00000302450.6_Splice_Site_p.P587_splice			Q8IYA6	CKP2L_HUMAN	cytoskeleton associated protein 2-like	587						centrosome				breast(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(15)|skin(1)|upper_aerodigestive_tract(1)	28						CTCTTGTATTGGCTGGAAGGA	0.294000													3	32					0	0	1	0	0
CNNM2	54805	broad.mit.edu	37	10	104836767	104836767	+	Missense_Mutation	SNP	C	C	T			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr10:104836767C>T	ENST00000369878.3	+	8	2582	c.2458C>T	c.(2458-2460)Cgg>Tgg	p.R820W	CNNM2_ENST00000457502.2_Missense_Mutation_p.R578W|CNNM2_ENST00000433628.2_Missense_Mutation_p.R798W|CNNM2_ENST00000475511.1_3'UTR	NM_017649.4	NP_060119.3	Q9H8M5	CNNM2_HUMAN	cyclin M2	820					ion transport	integral to membrane				central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(7)|ovary(1)|prostate(2)|urinary_tract(1)	19		Colorectal(252;0.103)|all_hematologic(284;0.152)|Breast(234;0.198)		Epithelial(162;7.89e-09)|all cancers(201;1.82e-07)|BRCA - Breast invasive adenocarcinoma(275;0.215)		GATGGCATCCCGGATGGACAA	0.463000													6	96					0	0	1	0	0
BMP10	27302	broad.mit.edu	37	2	69093688	69093688	+	Missense_Mutation	SNP	G	G	A	rs141935259		TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr2:69093688G>A	ENST00000295379.1	-	2	508	c.350C>T	c.(349-351)cCg>cTg	p.P117L		NM_014482.1	NP_055297.1	O95393	BMP10_HUMAN	bone morphogenetic protein 10	117					activin receptor signaling pathway|adult heart development|atrial cardiac muscle tissue morphogenesis|BMP signaling pathway|cardiac muscle cell proliferation|heart trabecula formation|negative regulation of cardiac muscle hypertrophy|negative regulation of cell growth|negative regulation of endothelial cell migration|Notch signaling pathway|pathway-restricted SMAD protein phosphorylation|positive regulation of cardiac muscle cell proliferation|positive regulation of cardiac muscle hypertrophy|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of transcription, DNA-dependent|sarcomere organization|ventricular cardiac muscle cell development|ventricular cardiac muscle tissue morphogenesis	cell surface|extracellular space|Z disc	cytokine activity|growth factor activity|receptor serine/threonine kinase binding	p.P117L(1)		breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(15)|ovary(2)	27						AAAACTGACCGGCTGGGAAAA	0.428000													21	26					0	0	1	0	0
TAF7L	54457	broad.mit.edu	37	X	100536765	100536765	+	Splice_Site	SNP	T	T	A			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chrX:100536765T>A	ENST00000372907.3	-	6	676		c.e6-2		TAF7L_ENST00000324762.6_Splice_Site|TAF7L_ENST00000356784.1_Splice_Site|TAF7L_ENST00000372905.2_Splice_Site	NM_024885.3	NP_079161.3	Q5H9L4	TAF7L_HUMAN	TAF7-like RNA polymerase II, TATA box binding protein (TBP)-associated factor, 50kDa						cell differentiation|multicellular organismal development|regulation of transcription, DNA-dependent|spermatogenesis|transcription initiation from RNA polymerase II promoter	cytoplasm|transcription factor TFIID complex	binding			NS(1)|breast(4)|kidney(4)|large_intestine(4)|lung(7)|ovary(1)|pancreas(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	29						GTGGCGTAACTAAAATAAATA	0.373000													4	65					0	0	1	0	0
COG3	83548	broad.mit.edu	37	13	46054373	46054373	+	Missense_Mutation	SNP	C	C	A			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr13:46054373C>A	ENST00000349995.5	+	4	609	c.497C>A	c.(496-498)tCc>tAc	p.S166Y		NM_031431.3	NP_113619.2	Q96JB2	COG3_HUMAN	component of oligomeric golgi complex 3	166					ER to Golgi vesicle-mediated transport|intra-Golgi vesicle-mediated transport|intracellular protein transport|protein glycosylation|protein localization to organelle|protein stabilization|retrograde vesicle-mediated transport, Golgi to ER	cis-Golgi network|Golgi cisterna membrane|Golgi transport complex	protein binding|protein transporter activity			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(8)|prostate(2)|skin(2)|stomach(1)	24		Lung NSC(96;0.000145)|Breast(56;0.000596)|Prostate(109;0.00438)|Hepatocellular(98;0.0207)|Lung SC(185;0.0262)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;0.000124)		CTTTTTGTGTCCAATAAGACA	0.378000													3	67					0.115264	0.116087	1	1	0
OSBPL3	26031	broad.mit.edu	37	7	24854824	24854824	+	Splice_Site	SNP	T	T	A			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr7:24854824T>A	ENST00000313367.2	-	19	2479		c.e19-2		OSBPL3_ENST00000396429.1_Splice_Site|OSBPL3_ENST00000431825.2_Splice_Site|OSBPL3_ENST00000396431.1_Splice_Site|OSBPL3_ENST00000352860.1_Splice_Site|OSBPL3_ENST00000353930.1_Splice_Site|OSBPL3_ENST00000409069.1_Splice_Site	NM_015550.2	NP_056365.1	Q9H4L5	OSBL3_HUMAN	oxysterol binding protein-like 3						lipid transport		lipid binding|protein binding			breast(2)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(10)|lung(19)|prostate(1)|skin(3)|urinary_tract(1)	43						TCCCCAAAACTAAAAAGAAGG	0.378000													7	132					0	0	1	0	0
CHD7	55636	broad.mit.edu	37	8	61654168	61654168	+	Silent	SNP	T	T	A			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr8:61654168T>A	ENST00000423902.2	+	2	656	c.177T>A	c.(175-177)acT>acA	p.T59T	CHD7_ENST00000525508.1_Silent_p.T59T|CHD7_ENST00000524602.1_Silent_p.T59T	NM_017780.3	NP_060250.2	Q9P2D1	CHD7_HUMAN	chromodomain helicase DNA binding protein 7	59					central nervous system development|chromatin modification|cognition|cranial nerve development|face development|heart morphogenesis|in utero embryonic development|inner ear morphogenesis|nose development|palate development|regulation of growth hormone secretion|regulation of transcription, DNA-dependent|retina development in camera-type eye|skeletal system development|T cell differentiation|transcription, DNA-dependent	nucleus	ATP binding|chromatin binding|DNA binding|helicase activity			NS(1)|breast(6)|central_nervous_system(8)|cervix(2)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(16)|lung(49)|ovary(4)|pancreas(2)|prostate(4)|skin(2)|urinary_tract(3)	123		all_cancers(86;0.2)|all_lung(136;0.0402)|Lung NSC(129;0.0459)|all_epithelial(80;0.0477)	BRCA - Breast invasive adenocarcinoma(89;0.143)			ATCCTTCAACTAATCAAAATC	0.398000													3	44					0	0	1	0	0
TBC1D23	55773	broad.mit.edu	37	3	100016854	100016854	+	Missense_Mutation	SNP	G	G	A			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr3:100016854G>A	ENST00000394144.4	+	9	971	c.964G>A	c.(964-966)Gtg>Atg	p.V322M	TBC1D23_ENST00000475134.1_Missense_Mutation_p.V185M|TBC1D23_ENST00000486274.1_3'UTR|TBC1D23_ENST00000344949.5_Missense_Mutation_p.V322M	NM_001199198.2	NP_001186127.1	Q9NUY8	TBC23_HUMAN	TBC1 domain family, member 23	322						intracellular	Rab GTPase activator activity			breast(1)|endometrium(1)|large_intestine(7)|liver(1)|lung(10)|ovary(1)|prostate(2)|skin(2)	25						GGCCATCTCCGTGTCAGAGAT	0.433000													3	58					0	0	1	0	0
SPEG	10290	broad.mit.edu	37	2	220307861	220307861	+	Missense_Mutation	SNP	G	G	A			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr2:220307861G>A	ENST00000396698.1	+	2	71	c.65G>A	c.(64-66)cGa>cAa	p.R22Q	SPEG_ENST00000396695.2_5'UTR|SPEG_ENST00000312358.7_Intron			Q15772	SPEG_HUMAN	SPEG complex locus	0					muscle organ development|negative regulation of cell proliferation	nucleus	ATP binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(3)|endometrium(10)|kidney(2)|large_intestine(9)|lung(42)|ovary(5)|pancreas(1)|prostate(8)|skin(1)|stomach(9)|upper_aerodigestive_tract(4)|urinary_tract(4)	100		Renal(207;0.0183)		Epithelial(149;4.5e-10)|all cancers(144;7.93e-08)|Lung(261;0.00639)|LUSC - Lung squamous cell carcinoma(224;0.00829)|READ - Rectum adenocarcinoma(5;0.163)		GCCTTTGGCCGACTCACCCAT	0.587000													130	159					0	0	1	0	0
PDP2	57546	broad.mit.edu	37	16	66919031	66919031	+	Missense_Mutation	SNP	G	G	A			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr16:66919031G>A	ENST00000311765.2	+	2	1178	c.844G>A	c.(844-846)Gca>Aca	p.A282T	PDP2_ENST00000568720.1_Intron	NM_020786.2	NP_065837.1	Q9P2J9	PDP2_HUMAN	pyruvate dehyrogenase phosphatase catalytic subunit 2	282					pyruvate metabolic process|regulation of acetyl-CoA biosynthetic process from pyruvate	mitochondrial matrix|protein serine/threonine phosphatase complex	[pyruvate dehydrogenase (lipoamide)] phosphatase activity|metal ion binding			kidney(1)|large_intestine(2)|lung(6)|ovary(1)|prostate(1)|urinary_tract(1)	12		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.088)|Epithelial(162;0.204)		CTTGCACGTGGCAAATGCTGG	0.552000													3	104					0	0	1	0	0
TOPORS	10210	broad.mit.edu	37	9	32541886	32541886	+	Silent	SNP	A	A	T			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr9:32541886A>T	ENST00000360538.2	-	3	2753	c.2637T>A	c.(2635-2637)acT>acA	p.T879T	TOPORS_ENST00000379858.1_Silent_p.T814T	NM_005802.4	NP_005793.2	Q9NS56	TOPRS_HUMAN	topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase	879	Interaction with TOP1.|Interaction with UBE2I.|Lys-rich.				DNA damage response, signal transduction resulting in induction of apoptosis|maintenance of protein location in nucleus|proteasomal ubiquitin-dependent protein catabolic process|protein sumoylation|transcription, DNA-dependent	nuclear speck|PML body	antigen binding|DNA binding|DNA topoisomerase I binding|SUMO ligase activity|ubiquitin-protein ligase activity|zinc ion binding			large_intestine(6)|ovary(3)|skin(2)|upper_aerodigestive_tract(1)	12			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.0018)		tATGGTGTTTAGTTGTATCAG	0.383000													5	281					0	0	1	0	0
GRIA3	2892	broad.mit.edu	37	X	122551440	122551440	+	Missense_Mutation	SNP	A	A	T			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chrX:122551440A>T	ENST00000264357.5	+	11	1980	c.1688A>T	c.(1687-1689)tAc>tTc	p.Y563F	GRIA3_ENST00000542149.1_Missense_Mutation_p.Y563F|GRIA3_ENST00000541091.1_Missense_Mutation_p.Y547F|GRIA3_ENST00000371256.5_Missense_Mutation_p.Y563F|GRIA3_ENST00000371251.1_Missense_Mutation_p.Y563F	NM_000828.4	NP_000819.3	P42263	GRIA3_HUMAN	glutamate receptor, ionotropic, AMPA 3	563					glutamate signaling pathway|synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|endocytic vesicle membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity			breast(2)|central_nervous_system(1)|endometrium(8)|kidney(3)|large_intestine(8)|lung(25)|ovary(3)|pancreas(2)|skin(2)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(1)	57					L-Glutamic Acid(DB00142)	GTCTTTGCTTACATTGGAGTC	0.433000													5	321					0	0	1	0	0
CHD1	1105	broad.mit.edu	37	5	98204341	98204341	+	Splice_Site	SNP	T	T	A			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr5:98204341T>A	ENST00000284049.3	-	30	4257		c.e30-2		CHD1_ENST00000511067.1_Splice_Site	NM_001270.2	NP_001261.2	O14646	CHD1_HUMAN	chromodomain helicase DNA binding protein 1						regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding|methylated histone residue binding			NS(1)|breast(4)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(12)|ovary(2)|pancreas(1)|prostate(7)|skin(3)|urinary_tract(2)	49		all_cancers(142;5.36e-08)|all_epithelial(76;6.97e-11)|Lung NSC(167;0.000693)|Prostate(80;0.000986)|all_lung(232;0.00119)|Ovarian(225;0.024)|Colorectal(57;0.117)		COAD - Colon adenocarcinoma(37;0.0717)	Epirubicin(DB00445)	TTCACTCAACTAAAGAAAAAG	0.368000													4	134					0	0	1	0	0
N4BP2	55728	broad.mit.edu	37	4	40123308	40123308	+	Missense_Mutation	SNP	A	A	T			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr4:40123308A>T	ENST00000261435.6	+	9	3993	c.3577A>T	c.(3577-3579)Act>Tct	p.T1193S		NM_018177.4	NP_060647.2	Q86UW6	N4BP2_HUMAN	NEDD4 binding protein 2	1193						cytoplasm	ATP binding|ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity|endonuclease activity|protein binding			breast(4)|endometrium(3)|kidney(12)|large_intestine(7)|liver(2)|lung(22)|ovary(1)|pancreas(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(1)	60						CTCACAGTCTACTTGTGATGC	0.423000													4	150					0	0	1	0	0
OR4S2	219431	broad.mit.edu	37	11	55418477	55418477	+	Missense_Mutation	SNP	A	A	T			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr11:55418477A>T	ENST00000312422.2	+	1	98	c.98A>T	c.(97-99)tAc>tTc	p.Y33F		NM_001004059.2	NP_001004059.2	Q8NH73	OR4S2_HUMAN	olfactory receptor, family 4, subfamily S, member 2	33					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(2)|large_intestine(4)|lung(28)|ovary(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	45		all_epithelial(135;0.0748)				TCTTTCTTCTACATAATCATT	0.378000													5	269					0	0	1	0	0
ST6GALNAC1	55808	broad.mit.edu	37	17	74622001	74622001	+	Splice_Site	SNP	C	C	T			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr17:74622001C>T	ENST00000156626.7	-	8	1705		c.e8-1			NM_018414.3	NP_060884.1	Q9NSC7	SIA7A_HUMAN	ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1						protein glycosylation	integral to Golgi membrane	alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity			breast(2)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(11)|prostate(1)|upper_aerodigestive_tract(1)	22						CCTCAGAAACCTGTGAAATGC	0.567000													3	97					0	0	1	0	0
NETO2	81831	broad.mit.edu	37	16	47165938	47165938	+	Splice_Site	SNP	T	T	A			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr16:47165938T>A	ENST00000562435.1	-	2	419		c.e2-2		NETO2_ENST00000303155.5_Splice_Site	NM_018092.4	NP_060562.3	Q8NC67	NETO2_HUMAN	neuropilin (NRP) and tolloid (TLL)-like 2							integral to membrane	receptor activity			breast(1)|cervix(1)|endometrium(1)|large_intestine(8)|lung(11)|prostate(1)|skin(2)|upper_aerodigestive_tract(4)	29		all_cancers(37;0.00114)|all_lung(18;0.00432)|Lung NSC(13;0.0384)|Breast(268;0.174)				TTAACAACACTAGAGAAATAA	0.313000										HNSCC(25;0.065)			5	201					0	0	1	0	0
OR4K2	390431	broad.mit.edu	37	14	20345072	20345072	+	Missense_Mutation	SNP	A	A	T			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr14:20345072A>T	ENST00000298642.2	+	1	682	c.646A>T	c.(646-648)Aat>Tat	p.N216Y		NM_001005501.1	NP_001005501.1	Q8NGD2	OR4K2_HUMAN	olfactory receptor, family 4, subfamily K, member 2	216					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(5)|kidney(2)|large_intestine(6)|lung(16)|ovary(2)|skin(9)|upper_aerodigestive_tract(2)	43	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		TGTTTTATTTAATTCATATGT	0.383000													7	384					0	0	1	0	0
F5	2153	broad.mit.edu	37	1	169510502	169510502	+	Missense_Mutation	SNP	G	G	T	rs140018525	byFrequency	TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr1:169510502G>T	ENST00000367796.3	-	13	4042	c.3841C>A	c.(3841-3843)Ctt>Att	p.L1281I	F5_ENST00000367797.3_Missense_Mutation_p.L1276I			P12259	FA5_HUMAN	coagulation factor V (proaccelerin, labile factor)	1276	35 X 9 AA approximate tandem repeats of [TNP]-L-S-P-D-L-S-Q-T.|B.				cell adhesion|platelet activation|platelet degranulation	plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity			NS(1)|breast(4)|central_nervous_system(4)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(24)|lung(55)|ovary(3)|prostate(4)|skin(5)|stomach(1)|upper_aerodigestive_tract(7)|urinary_tract(1)	128	all_hematologic(923;0.208)				Drotrecogin alfa(DB00055)	TCTGGAGAAAGGGGCATCTGA	0.502000													5	609					0.0293803	0.0298031	1	1	0
ALPK2	115701	broad.mit.edu	37	18	56247390	56247390	+	Missense_Mutation	SNP	A	A	T			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr18:56247390A>T	ENST00000361673.3	-	4	831	c.618T>A	c.(616-618)agT>agA	p.S206R		NM_052947.3	NP_443179.3	Q86TB3	ALPK2_HUMAN	alpha-kinase 2	206							ATP binding|protein serine/threonine kinase activity			NS(1)|central_nervous_system(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(13)|lung(33)|ovary(7)|prostate(1)|skin(10)|upper_aerodigestive_tract(2)	84						CTTCTGTGTTACTTGGATCAT	0.403000													7	239					0	0	1	0	0
SLC9C2	284525	broad.mit.edu	37	1	173523950	173523950	+	Missense_Mutation	SNP	T	T	A			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr1:173523950T>A	ENST00000367714.3	-	11	1641	c.1219A>T	c.(1219-1221)Ata>Tta	p.I407L	SLC9C2_ENST00000466087.1_Intron|SLC9C2_ENST00000536496.1_Missense_Mutation_p.I305L	NM_178527.3	NP_848622.2	Q5TAH2	S9A11_HUMAN	solute carrier family 9, member C2 (putative)	407					sodium ion transport	integral to membrane	ion channel activity|solute:hydrogen antiporter activity										ACATAGAGTATAAACTAAAAA	0.294000													6	146					0	0	1	0	0
SLIT2	9353	broad.mit.edu	37	4	20552448	20552448	+	Splice_Site	SNP	A	A	T			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr4:20552448A>T	ENST00000504154.1	+	25	2741		c.e25-1		SLIT2_ENST00000509394.2_Splice_Site|SLIT2_ENST00000503823.1_Splice_Site|SLIT2_ENST00000503837.1_Splice_Site|SLIT2_ENST00000273739.5_Splice_Site	NM_004787.1	NP_004778.1	O94813	SLIT2_HUMAN	slit homolog 2 (Drosophila)						apoptosis involved in luteolysis|axon extension involved in axon guidance|branching morphogenesis of a tube|cell migration involved in sprouting angiogenesis|cellular response to heparin|cellular response to hormone stimulus|chemorepulsion involved in postnatal olfactory bulb interneuron migration|corticospinal neuron axon guidance through spinal cord|induction of negative chemotaxis|motor axon guidance|negative regulation of actin filament polymerization|negative regulation of cell growth|negative regulation of cellular response to growth factor stimulus|negative regulation of chemokine-mediated signaling pathway|negative regulation of endothelial cell migration|negative regulation of lamellipodium assembly|negative regulation of mononuclear cell migration|negative regulation of neutrophil chemotaxis|negative regulation of protein phosphorylation|negative regulation of retinal ganglion cell axon guidance|negative regulation of small GTPase mediated signal transduction|negative regulation of smooth muscle cell chemotaxis|negative regulation of vascular permeability|positive regulation of apoptosis|positive regulation of axonogenesis|response to cortisol stimulus|retinal ganglion cell axon guidance|Roundabout signaling pathway|ureteric bud development	cell surface|cytoplasm|extracellular space|plasma membrane	calcium ion binding|GTPase inhibitor activity|heparin binding|laminin-1 binding|protein homodimerization activity|proteoglycan binding|Roundabout binding			NS(1)|breast(4)|central_nervous_system(4)|cervix(1)|endometrium(5)|kidney(7)|large_intestine(17)|lung(60)|ovary(3)|pancreas(1)|prostate(2)|skin(10)|upper_aerodigestive_tract(1)	116						TCTTTCTTTTAGTTCTCTACA	0.313000													7	80					0	0	1	0	0
C2CD2L	9854	broad.mit.edu	37	11	118981555	118981555	+	Splice_Site	SNP	A	A	T			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr11:118981555A>T	ENST00000336702.3	+	4	929		c.e4-1			NM_014807.3	NP_055622.3	O14523	C2C2L_HUMAN	C2CD2-like							integral to membrane				NS(1)|endometrium(1)|large_intestine(2)|lung(8)|prostate(1)	13						TCCTGTCTGTAGTTGGAAGTC	0.527000													5	310					0	0	1	0	0
NCOA2	10499	broad.mit.edu	37	8	71129001	71129001	+	Splice_Site	SNP	T	T	A			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr8:71129001T>A	ENST00000452400.2	-	3	163		c.e3-2			NM_006540.2	NP_006531.1	Q15596	NCOA2_HUMAN	nuclear receptor coactivator 2						cellular lipid metabolic process|transcription, DNA-dependent	nucleoplasm	histone acetyltransferase activity|ligand-dependent nuclear receptor binding|nuclear hormone receptor binding|signal transducer activity		PAX3/NCOA2(4)|HEY1/NCOA2(10)	NS(1)|breast(4)|endometrium(7)|kidney(4)|large_intestine(10)|lung(25)|ovary(1)|pancreas(2)|prostate(2)|skin(4)	60	Breast(64;0.201)		Epithelial(68;0.0147)|OV - Ovarian serous cystadenocarcinoma(28;0.0455)|all cancers(69;0.0606)			TATCAGCAACTAAAACAGAAA	0.408000			T	"""RUNXBP2, HEY1"""	"""AML, Chondrosarcoma"""								5	115					0	0	1	0	0
KRTAP4-11	653240	broad.mit.edu	37	17	39274371	39274371	+	Missense_Mutation	SNP	C	C	T			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr17:39274371C>T	ENST00000391413.2	-	1	235	c.197G>A	c.(196-198)cGc>cAc	p.R66H		NM_033059.3	NP_149048.2	Q9BYQ6	KR411_HUMAN	keratin associated protein 4-11	66	27 X 5 AA repeats of C-C-[GIKRQVHEL]- [SPTR]-[STVQRMC].		Missing (in allele KAP4.14).			keratin filament				endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|lung(8)|prostate(5)|skin(1)	33		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000371)			GCATCTGGGGCGGCAGCAGGT	0.657000													3	26					0	0	1	0	0
EIF2AK3	9451	broad.mit.edu	37	2	88890125	88890125	+	Splice_Site	SNP	T	T	A			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr2:88890125T>A	ENST00000303236.3	-	6	1304		c.e6-2		EIF2AK3_ENST00000419748.1_Splice_Site	NM_004836.5	NP_004827.4	Q9NZJ5	E2AK3_HUMAN	eukaryotic translation initiation factor 2-alpha kinase 3						activation of caspase activity|bone mineralization|calcium-mediated signaling|chondrocyte development|endocrine pancreas development|endoplasmic reticulum organization|endoplasmic reticulum unfolded protein response|ER overload response|insulin secretion|insulin-like growth factor receptor signaling pathway|negative regulation of myelination|negative regulation of translational initiation in response to stress|protein autophosphorylation|protein homooligomerization	endoplasmic reticulum membrane|integral to membrane	ATP binding|eukaryotic translation initiation factor 2alpha kinase activity|identical protein binding			ovary(3)	3						AGTACAAAACTAAACAAAAAT	0.303000													4	55					0	0	1	0	0
DISP1	84976	broad.mit.edu	37	1	223163965	223163965	+	Splice_Site	SNP	A	A	T			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr1:223163965A>T	ENST00000284476.6	+	4	703		c.e4-1		DISP1_ENST00000495684.1_Splice_Site	NM_032890.3	NP_116279.2	Q96F81	DISP1_HUMAN	dispatched homolog 1 (Drosophila)						diaphragm development|protein homotrimerization|regulation of protein secretion|smoothened signaling pathway	basolateral plasma membrane|integral to membrane	hedgehog receptor activity|peptide transporter activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(3)|large_intestine(20)|lung(25)|prostate(4)|skin(1)|stomach(1)|urinary_tract(5)	69				GBM - Glioblastoma multiforme(131;0.102)		TGTGTTTTGTAGTTATGCAGC	0.478000													5	203					0	0	1	0	0
VPS8	23355	broad.mit.edu	37	3	184570286	184570286	+	Splice_Site	SNP	A	A	T			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr3:184570286A>T	ENST00000287546.4	+	10	924		c.e10-1		VPS8_ENST00000437079.3_Splice_Site|VPS8_ENST00000446204.2_Splice_Site|VPS8_ENST00000436792.2_Splice_Site	NM_015303.3	NP_056118.2	Q8N3P4	VPS8_HUMAN	vacuolar protein sorting 8 homolog (S. cerevisiae)								zinc ion binding			NS(1)|breast(1)|central_nervous_system(3)|cervix(1)|endometrium(6)|kidney(4)|large_intestine(11)|lung(19)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	54	all_cancers(143;2.51e-11)|Ovarian(172;0.0339)|Breast(254;0.247)		Epithelial(37;1.02e-33)|OV - Ovarian serous cystadenocarcinoma(80;4.81e-22)			TTCTCTGTTTAGTTTACAGAT	0.299000													5	93					0	0	1	0	0
PREP	5550	broad.mit.edu	37	6	105800954	105800954	+	Splice_Site	SNP	T	T	A			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr6:105800954T>A	ENST00000369110.3	-	7	910		c.e7-2			NM_002726.4	NP_002717.3	P48147	PPCE_HUMAN	prolyl endopeptidase						proteolysis		serine-type endopeptidase activity			breast(1)|endometrium(2)|large_intestine(7)|lung(12)|ovary(3)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	29		all_cancers(87;0.000128)|Acute lymphoblastic leukemia(125;1.9e-08)|all_hematologic(75;9.25e-07)|all_epithelial(87;0.0344)|Lung NSC(302;0.191)|Colorectal(196;0.202)			Oxytocin(DB00107)	ATCAGATAACTAAAAAAGAAA	0.343000													8	95					0	0	1	0	0
DAW1	164781	broad.mit.edu	37	2	228771852	228771852	+	Splice_Site	SNP	A	A	T			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr2:228771852A>T	ENST00000373666.2	+	10	1494		c.e10-1		DAW1_ENST00000545118.1_Splice_Site|DAW1_ENST00000309931.2_Splice_Site					dynein assembly factor with WDR repeat domains 1																		TTTTAATTGTAGCTGTGGGAT	0.378000													4	136					0	0	1	0	0
F2	2147	broad.mit.edu	37	11	46760614	46760614	+	Silent	SNP	A	A	G			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr11:46760614A>G	ENST00000311907.5	+	13	1727	c.1671A>G	c.(1669-1671)gaA>gaG	p.E557E	F2_ENST00000530231.1_Silent_p.E518E	NM_000506.3	NP_000497.1	P00734	THRB_HUMAN	coagulation factor II (thrombin)	557	High affinity receptor-binding region which is also known as the TP508 peptide.|Peptidase S1.				activation of caspase activity|acute-phase response|blood coagulation, intrinsic pathway|cell surface receptor linked signaling pathway|cytosolic calcium ion homeostasis|fibrinolysis|leukocyte migration|negative regulation of astrocyte differentiation|negative regulation of fibrinolysis|negative regulation of platelet activation|negative regulation of proteolysis|peptidyl-glutamic acid carboxylation|platelet activation|positive regulation of collagen biosynthetic process|positive regulation of protein phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of release of sequestered calcium ion into cytosol|post-translational protein modification|proteolysis|STAT protein import into nucleus|tyrosine phosphorylation of STAT protein	cytosol|endoplasmic reticulum lumen|extracellular space|Golgi lumen|plasma membrane|soluble fraction	calcium ion binding|growth factor activity|serine-type endopeptidase activity|thrombospondin receptor activity	p.E557E(1)		endometrium(3)|kidney(2)|large_intestine(4)|lung(10)|ovary(3)|prostate(2)|stomach(2)|upper_aerodigestive_tract(1)	27		all_lung(304;0.000414)|Lung NSC(402;0.0011)		BRCA - Breast invasive adenocarcinoma(625;0.146)	Antihemophilic Factor(DB00025)|Argatroban(DB00278)|Bivalirudin(DB00006)|Coagulation Factor IX(DB00100)|Drotrecogin alfa(DB00055)|Enoxaparin(DB01225)|Heparin(DB01109)|Lepirudin(DB00001)|Menadione(DB00170)|Proflavine(DB01123)|Simvastatin(DB00641)|Suramin(DB04786)|Warfarin(DB00682)|Ximelagatran(DB04898)	AGCCTGATGAAGGGAAACGAG	0.552000													3	181					0	0	1	0	0
R3HDM1	23518	broad.mit.edu	37	2	136481505	136481505	+	Splice_Site	SNP	A	A	T			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr2:136481505A>T	ENST00000264160.4	+	26	3314		c.e26-1		R3HDM1_ENST00000410054.1_Splice_Site|R3HDM1_ENST00000409606.1_Splice_Site|R3HDM1_ENST00000329971.3_Splice_Site|R3HDM1_ENST00000409478.1_Splice_Site	NM_015361.2	NP_056176.2	Q15032	R3HD1_HUMAN	R3H domain containing 1								nucleic acid binding			breast(2)|endometrium(6)|kidney(5)|large_intestine(3)|lung(14)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|urinary_tract(3)	38				BRCA - Breast invasive adenocarcinoma(221;0.127)		TTTCTATTCTAGTTGTTGGGA	0.388000													4	84					0	0	1	0	0
EP300	2033	broad.mit.edu	37	22	41566408	41566408	+	Splice_Site	SNP	A	A	T			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr22:41566408A>T	ENST00000263253.7	+	27	5505		c.e27-1		RP1-85F18.6_ENST00000415054.1_RNA	NM_001429.3	NP_001420.2	Q09472	EP300_HUMAN	E1A binding protein p300						apoptosis|cell cycle|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|histone H4 acetylation|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of androgen receptor signaling pathway|response to estrogen stimulus|response to hypoxia	centrosome|histone acetyltransferase complex	androgen receptor binding|beta-catenin binding|DNA binding|histone acetyltransferase activity|RNA polymerase II activating transcription factor binding|transcription coactivator activity|zinc ion binding			NS(2)|breast(11)|central_nervous_system(7)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(31)|kidney(5)|large_intestine(31)|liver(2)|lung(33)|ovary(2)|pancreas(4)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(16)	171						TTGTATTGTTAGTTACACAAC	0.383000			"""T,  N, F, Mis, O"""	"""MLL, RUNXBP2"""	"""colorectal, breast, pancreatic, AML, ALL, DLBCL"""				Rubinstein-Taybi syndrome				4	117					0	0	1	0	0
DCAF17	80067	broad.mit.edu	37	2	172314880	172314880	+	Splice_Site	SNP	A	A	T			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr2:172314880A>T	ENST00000375255.3	+	8	1059		c.e8-1		DCAF17_ENST00000468592.1_Intron|DCAF17_ENST00000539783.1_Splice_Site	NM_025000.3	NP_079276.2	Q5H9S7	DCA17_HUMAN	DDB1 and CUL4 associated factor 17							CUL4 RING ubiquitin ligase complex|integral to membrane|nucleolus				endometrium(1)|kidney(2)|large_intestine(3)|lung(10)|prostate(1)	17						TTTTGTTTTTAGTTCATGCAA	0.358000													12	136					0	0	1	0	0
HMGN2P46	283651	broad.mit.edu	37	15	45848217	45848217	+	RNA	SNP	A	A	G			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr15:45848217A>G	ENST00000409454.1	+	0	1212																											ATAAAAATGCAGATTTTGTTT	0.313000													3	41					0	0	1	0	0
SMG7	9887	broad.mit.edu	37	1	183495733	183495733	+	Missense_Mutation	SNP	A	A	T			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr1:183495733A>T	ENST00000367537.3	+	6	597	c.402A>T	c.(400-402)ttA>ttT	p.L134F	SMG7_ENST00000507469.1_Missense_Mutation_p.L105F|SMG7_ENST00000508461.1_Missense_Mutation_p.L63F|SMG7_ENST00000347615.2_Missense_Mutation_p.L105F|SMG7_ENST00000507406.1_3'UTR|SMG7_ENST00000515829.2_Missense_Mutation_p.L105F|SMG7_ENST00000456731.2_Missense_Mutation_p.L63F			Q92540	SMG7_HUMAN	SMG7 nonsense mediated mRNA decay factor	105					mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of dephosphorylation	cytoplasm|intermediate filament cytoskeleton|nucleus	protein phosphatase 2A binding			breast(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(7)|lung(16)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	46						TCTTTTAGTTATTACAAGAAC	0.348000													4	143					0	0	1	0	0
MSMP	692094	broad.mit.edu	37	9	35753222	35753222	+	Missense_Mutation	SNP	T	T	G			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr9:35753222T>G	ENST00000436428.2	-	3	434	c.295A>C	c.(295-297)Acc>Ccc	p.T99P	RGP1_ENST00000378078.4_3'UTR|MSMP_ENST00000414286.1_5'UTR	NM_001044264.2	NP_001037729.1	Q1L6U9	MSMP_HUMAN	microseminoprotein, prostate associated	99						extracellular region				endometrium(2)|kidney(1)|lung(3)|prostate(3)	9						AACTGGCAGGTTCCTGCCTCC	0.607000													9	38					0	0	1	0	0
ACSM2A	123876	broad.mit.edu	37	16	20482856	20482856	+	Splice_Site	SNP	A	A	T			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr16:20482856A>T	ENST00000573854.1	+	6	854		c.e6-1		ACSM2A_ENST00000575690.1_Splice_Site|ACSM2A_ENST00000575558.1_Splice_Site|ACSM2A_ENST00000396104.2_Splice_Site|ACSM2A_ENST00000536134.1_Splice_Site|ACSM2A_ENST00000417235.2_Splice_Site|ACSM2A_ENST00000219054.6_Splice_Site	NM_001010845.2	NP_001010845.1	Q08AH3	ACS2A_HUMAN	acyl-CoA synthetase medium-chain family member 2A						fatty acid metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|metal ion binding			breast(2)|central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(3)|lung(34)|ovary(1)|skin(6)|stomach(1)	51						CTGTGTTTTCAGTTGGACAGG	0.483000													6	295					0	0	1	0	0
TAS2R3	50831	broad.mit.edu	37	7	141464695	141464695	+	Missense_Mutation	SNP	A	A	T			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr7:141464695A>T	ENST00000247879.2	+	1	799	c.737A>T	c.(736-738)tAc>tTc	p.Y246F	SSBP1_ENST00000465582.1_Intron	NM_016943.2	NP_058639.1	Q9NYW6	TA2R3_HUMAN	taste receptor, type 2, member 3	246					sensory perception of taste		taste receptor activity			breast(1)|central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(4)|lung(5)	14	Melanoma(164;0.0171)					ttcttactttactttcttgct	0.418000													8	185					0	0	1	0	0
SAMD9	54809	broad.mit.edu	37	7	92733627	92733627	+	Missense_Mutation	SNP	A	A	T			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr7:92733627A>T	ENST00000379958.2	-	3	2053	c.1784T>A	c.(1783-1785)aTa>aAa	p.I595K		NM_001193307.1|NM_017654.3	NP_001180236.1|NP_060124.2	Q5K651	SAMD9_HUMAN	sterile alpha motif domain containing 9	595						cytoplasm				NS(1)|breast(4)|central_nervous_system(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(20)|lung(32)|ovary(4)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	88	all_cancers(62;5.71e-11)|all_epithelial(64;3.25e-10)|Breast(17;0.000675)|Lung NSC(181;0.0969)|all_lung(186;0.125)		STAD - Stomach adenocarcinoma(171;0.000302)			TTGGTGTTTTATTAATCTTGC	0.353000													4	86					0	0	1	0	0
SSPO	23145	broad.mit.edu	37	7	149500430	149500430	+	RNA	SNP	T	T	A			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr7:149500430T>A	ENST00000378016.2	+	0	7956							A2VEC9	SSPO_HUMAN	SCO-spondin						cell adhesion	extracellular space	peptidase inhibitor activity					Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			GTGGGCATTGTGTGGAAGGTG	0.652000													2	0					0	0	1	0	0
ZNF845	91664	broad.mit.edu	37	19	53856730	53856730	+	Silent	SNP	G	G	A			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr19:53856730G>A	ENST00000458035.1	+	4	2919	c.2802G>A	c.(2800-2802)aaG>aaA	p.K934K	ZNF845_ENST00000595091.1_Silent_p.K934K	NM_138374.1	NP_612383.1	Q96IR2	ZN845_HUMAN	zinc finger protein 845	934					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.K934K(3)		endometrium(2)|kidney(10)|lung(7)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|urinary_tract(2)	26						TAATTCATAAGACAATTCATA	0.368000													3	23					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179614538	179614538	+	Missense_Mutation	SNP	C	C	T			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr2:179614538C>T	ENST00000360870.5	-	46	12811	c.12589G>A	c.(12589-12591)Gtc>Atc	p.V4197I	TTN_ENST00000589042.1_Intron|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron|TTN_ENST00000591111.1_Intron|TTN_ENST00000359218.5_Intron|TTN-AS1_ENST00000578746.1_RNA|TTN_ENST00000342992.6_Intron|TTN_ENST00000342175.6_Intron|TTN-AS1_ENST00000590773.1_RNA	NM_133379.3	NP_596870.2	Q8WZ42	TITIN_HUMAN	titin	3541							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTTAAAAGGACTCCATTTTGA	0.363000													3	83					0	0	1	0	0
MCC	4163	broad.mit.edu	37	5	112363128	112363128	+	Silent	SNP	C	C	T			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr5:112363128C>T	ENST00000302475.4	-	17	2924	c.2361G>A	c.(2359-2361)ctG>ctA	p.L787L	MCC_ENST00000514701.3_5'UTR|MCC_ENST00000515367.2_Silent_p.L724L|MCC_ENST00000408903.3_Silent_p.L977L	NM_002387.2	NP_002378.1	P23508	CRCM_HUMAN	mutated in colorectal cancers	787					negative regulation of canonical Wnt receptor signaling pathway|negative regulation of epithelial cell migration|negative regulation of epithelial cell proliferation|Wnt receptor signaling pathway	cytoplasm|nucleus|plasma membrane	protein binding|receptor activity			endometrium(4)|kidney(3)|large_intestine(15)|liver(2)|lung(8)|ovary(2)|pancreas(1)|prostate(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	42		all_cancers(142;5.89e-08)|all_epithelial(76;3.57e-11)|all_lung(232;0.000605)|Lung NSC(810;0.000697)|Colorectal(10;0.00146)|Prostate(80;0.00174)|Ovarian(225;0.0175)|Breast(839;0.198)		OV - Ovarian serous cystadenocarcinoma(64;2.04e-54)|Epithelial(69;9.69e-49)|all cancers(49;6.25e-44)|COAD - Colon adenocarcinoma(37;0.0432)|Colorectal(14;0.0766)		CTAACTTCTTCAGTTTGTTTT	0.448000													4	235					0	0	1	0	0
BPIFC	254240	broad.mit.edu	37	22	32833840	32833840	+	Splice_Site	SNP	T	T	A			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr22:32833840T>A	ENST00000397452.1	-	8	766		c.e8-2		BPIFC_ENST00000432451.2_Splice_Site|BPIFC_ENST00000300399.3_Splice_Site|BPIFC_ENST00000534972.1_Splice_Site			Q8NFQ6	BPIL2_HUMAN	BPI fold containing family C							extracellular region	lipopolysaccharide binding|phospholipid binding										TGGTTAAAACTAAATAACCAA	0.303000													4	72					0	0	1	0	0
TSGA10	80705	broad.mit.edu	37	2	99689497	99689497	+	Missense_Mutation	SNP	T	T	C			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr2:99689497T>C	ENST00000393483.3	-	13	1766	c.922A>G	c.(922-924)Atg>Gtg	p.M308V	TSGA10_ENST00000410001.1_Missense_Mutation_p.M308V|TSGA10_ENST00000539964.1_Missense_Mutation_p.M308V|TSGA10_ENST00000542655.1_Intron|TSGA10_ENST00000478090.1_5'UTR|TSGA10_ENST00000355053.4_Missense_Mutation_p.M308V	NM_025244.2	NP_079520.1	Q9BZW7	TSG10_HUMAN	testis specific, 10	308					spermatogenesis	cytoplasm|nuclear membrane				NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(10)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	34						GCCTGTTCCATCTCAGCAATG	0.338000													4	162					0	0	1	0	0
PKD2	5311	broad.mit.edu	37	4	88967931	88967931	+	Missense_Mutation	SNP	A	A	T			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr4:88967931A>T	ENST00000237596.2	+	6	1523	c.1457A>T	c.(1456-1458)tAc>tTc	p.Y486F	PKD2_ENST00000508588.1_Intron	NM_000297.3	NP_000288.1	Q13563	PKD2_HUMAN	polycystic kidney disease 2 (autosomal dominant)	486						basal cortex|basal plasma membrane|endoplasmic reticulum|integral to membrane|lamellipodium|microtubule basal body	calcium ion binding|cytoskeletal protein binding|voltage-gated chloride channel activity|voltage-gated sodium channel activity			breast(1)|endometrium(4)|kidney(1)|large_intestine(8)|liver(2)|lung(15)|skin(4)|upper_aerodigestive_tract(1)	36		Hepatocellular(203;0.114)|Acute lymphoblastic leukemia(40;0.221)		OV - Ovarian serous cystadenocarcinoma(123;9.98e-10)|COAD - Colon adenocarcinoma(81;0.0237)		TTTATCTTTTACTATGTGGTG	0.383000													7	215					0	0	1	0	0
EHHADH	1962	broad.mit.edu	37	3	184966307	184966307	+	Splice_Site	SNP	T	T	A			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr3:184966307T>A	ENST00000231887.3	-	2	150		c.e2-2		EHHADH_ENST00000440662.1_Splice_Site|EHHADH_ENST00000456310.1_Splice_Site|EHHADH_ENST00000475987.1_Splice_Site	NM_001166415.1|NM_001966.3	NP_001159887.1|NP_001957.2	Q08426	ECHP_HUMAN	enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase							peroxisome	3-hydroxyacyl-CoA dehydrogenase activity|coenzyme binding|dodecenoyl-CoA delta-isomerase activity|enoyl-CoA hydratase activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(9)|ovary(3)|prostate(2)|skin(3)	24	all_cancers(143;4.04e-11)|Ovarian(172;0.0339)|Breast(254;0.247)		Epithelial(37;1.98e-32)|OV - Ovarian serous cystadenocarcinoma(80;5.55e-21)		NADH(DB00157)	AAAGTCGTACTAAAAGAAAAC	0.323000													4	71					0	0	1	0	0
PCNT	5116	broad.mit.edu	37	21	47754527	47754527	+	Missense_Mutation	SNP	A	A	G			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr21:47754527A>G	ENST00000359568.5	+	3	591	c.484A>G	c.(484-486)Agt>Ggt	p.S162G	PCNT_ENST00000480896.1_3'UTR	NM_006031.5	NP_006022.3	O95613	PCNT_HUMAN	pericentrin	162					cilium assembly|G2/M transition of mitotic cell cycle	cytosol|microtubule	calmodulin binding			NS(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(15)|liver(2)|lung(41)|ovary(5)|pancreas(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	104	Breast(49;0.112)					GTTCACAGTCAGTGACCACCC	0.552000													6	246					0	0	1	0	0
ZNF462	58499	broad.mit.edu	37	9	109689490	109689490	+	Silent	SNP	A	A	C			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr9:109689490A>C	ENST00000277225.5	+	3	3586	c.3297A>C	c.(3295-3297)ccA>ccC	p.P1099P	ZNF462_ENST00000457913.1_Silent_p.P1099P			Q96JM2	ZN462_HUMAN	zinc finger protein 462	1099					transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.P1099P(1)		NS(2)|autonomic_ganglia(2)|breast(5)|central_nervous_system(4)|cervix(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(17)|large_intestine(20)|lung(32)|ovary(5)|prostate(6)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	119						TGGGTTCCCCACCCCCCCCAC	0.532000													4	57					0	0	1	0	0
CCDC58	131076	broad.mit.edu	37	3	122087171	122087171	+	Splice_Site	SNP	T	T	A			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr3:122087171T>A	ENST00000291458.5	-	3	184		c.e3-2		CCDC58_ENST00000497726.1_Intron|CCDC58_ENST00000479899.1_Splice_Site	NM_001017928.2	NP_001017928.1	Q4VC31	CCD58_HUMAN	coiled-coil domain containing 58											large_intestine(1)|lung(1)	2				GBM - Glioblastoma multiforme(114;0.148)		TGCCATCAACTAAAAGAACAA	0.328000													5	73					0	0	1	0	0
HS3ST2	9956	broad.mit.edu	37	16	22826356	22826356	+	Missense_Mutation	SNP	C	C	T			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr16:22826356C>T	ENST00000261374.3	+	1	859	c.425C>T	c.(424-426)gCc>gTc	p.A142V		NM_006043.1	NP_006034.1	Q9Y278	HS3S2_HUMAN	heparan sulfate (glucosamine) 3-O-sulfotransferase 2	142						Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine 3-sulfotransferase 2 activity			breast(2)|kidney(1)|large_intestine(5)|liver(2)|lung(5)|ovary(1)|pancreas(2)|skin(1)	19				GBM - Glioblastoma multiforme(48;0.0299)		GACGTGCGGGCCTTGGGCACG	0.647000													14	24					0	0	1	0	0
NMRK1	54981	broad.mit.edu	37	9	77684818	77684818	+	Missense_Mutation	SNP	T	T	A			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr9:77684818T>A	ENST00000376811.1	-	6	784	c.322A>T	c.(322-324)Aat>Tat	p.N108Y	NMRK1_ENST00000376808.4_Missense_Mutation_p.N104Y|NMRK1_ENST00000361092.4_Missense_Mutation_p.N104Y			Q9NWW6	NRK1_HUMAN	nicotinamide riboside kinase 1	104					pyridine nucleotide biosynthetic process		ATP binding|metal ion binding|ribosylnicotinamide kinase activity										TACTTATAATTAAAAAGAAGA	0.408000													4	114					0	0	1	0	0
TCHHL1	126637	broad.mit.edu	37	1	152058043	152058043	+	Missense_Mutation	SNP	A	A	T			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr1:152058043A>T	ENST00000368806.1	-	3	2179	c.2115T>A	c.(2113-2115)agT>agA	p.S705R		NM_001008536.1	NP_001008536.1	Q5QJ38	TCHL1_HUMAN	trichohyalin-like 1	705							calcium ion binding			breast(4)|endometrium(1)|kidney(2)|large_intestine(9)|lung(33)|ovary(2)|prostate(1)|skin(7)|stomach(1)	60	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.246)			CTTCTTTGCTACTTGGGCCTT	0.458000													6	394					0	0	1	0	0
NPL	80896	broad.mit.edu	37	1	182794914	182794914	+	Splice_Site	SNP	A	A	T			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr1:182794914A>T	ENST00000367554.3	+	10	999		c.e10-1		NPL_ENST00000367555.1_Splice_Site|NPL_ENST00000367552.2_Splice_Site|NPL_ENST00000258317.2_Splice_Site|NPL_ENST00000463899.1_Splice_Site|NPL_ENST00000367553.1_Splice_Site	NM_001200050.1	NP_001186979.1	Q9BXD5	NPL_HUMAN	N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase)						carbohydrate metabolic process	cytoplasm	N-acetylneuraminate lyase activity			breast(1)|central_nervous_system(1)|large_intestine(5)|liver(1)|lung(4)|ovary(1)|skin(1)|stomach(1)	15						GTTCTTTTCTAGTTTTGTATC	0.338000													6	203					0	0	1	0	0
KIAA1324L	222223	broad.mit.edu	37	7	86548534	86548534	+	Splice_Site	SNP	A	A	T			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr7:86548534A>T	ENST00000450689.2	-	11	1676		c.e11+1		KIAA1324L_ENST00000444627.1_Splice_Site|KIAA1324L_ENST00000416314.1_Splice_Site|KIAA1324L_ENST00000490995.1_Splice_Site|KIAA1324L_ENST00000297222.6_Splice_Site	NM_001142749.2	NP_001136221.1	A8MWY0	K132L_HUMAN	KIAA1324-like							integral to membrane				breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(14)|ovary(6)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	44	Esophageal squamous(14;0.0058)					TGTTTTCCTTACTTAAATCCT	0.383000													4	92					0	0	1	0	0
NPAS3	64067	broad.mit.edu	37	14	33836390	33836390	+	Splice_Site	SNP	A	A	T			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr14:33836390A>T	ENST00000548645.1	+	3	340		c.e3-1		NPAS3_ENST00000356141.4_Splice_Site|NPAS3_ENST00000547068.1_Intron|NPAS3_ENST00000346562.2_Intron|NPAS3_ENST00000341321.4_Splice_Site|NPAS3_ENST00000551008.1_Splice_Site|NPAS3_ENST00000551492.1_Intron|NPAS3_ENST00000357798.5_Splice_Site			Q8IXF0	NPAS3_HUMAN	neuronal PAS domain protein 3						regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|signal transducer activity			breast(4)|endometrium(3)|kidney(1)|large_intestine(6)|liver(2)|lung(14)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	40	Breast(36;0.0102)|Hepatocellular(127;0.133)		LUAD - Lung adenocarcinoma(48;0.00169)|Lung(238;0.00968)	GBM - Glioblastoma multiforme(1;1.31e-09)|all cancers(1;0.000112)|OV - Ovarian serous cystadenocarcinoma(311;0.115)		TTTTCTTTTAAGTTATAGGTG	0.368000													4	35					0	0	1	0	0
RSBN1	54665	broad.mit.edu	37	1	114340601	114340601	+	Missense_Mutation	SNP	A	A	T			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr1:114340601A>T	ENST00000261441.5	-	2	824	c.761T>A	c.(760-762)aTa>aAa	p.I254K		NM_018364.3	NP_060834.2	Q5VWQ0	RSBN1_HUMAN	round spermatid basic protein 1	254	Poly-Lys.					nucleus				breast(1)|endometrium(2)|large_intestine(4)|lung(16)|ovary(1)|prostate(3)|urinary_tract(2)	29	Lung SC(450;0.184)	all_cancers(81;3.78e-08)|all_epithelial(167;5.56e-08)|all_lung(203;6.97e-06)|Lung NSC(69;1.18e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		TTTCTTCTTTATTTTCTTCAA	0.403000													7	332					0	0	1	0	0
ELOVL5	60481	broad.mit.edu	37	6	53141056	53141056	+	Splice_Site	SNP	T	T	A			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr6:53141056T>A	ENST00000542638.1	-	4	694		c.e4-2		ELOVL5_ENST00000486973.1_Splice_Site|ELOVL5_ENST00000304434.6_Splice_Site|ELOVL5_ENST00000541407.1_Splice_Site|ELOVL5_ENST00000370918.4_Splice_Site			Q9NYP7	ELOV5_HUMAN	ELOVL fatty acid elongase 5						fatty acid elongation, monounsaturated fatty acid|fatty acid elongation, polyunsaturated fatty acid|long-chain fatty-acyl-CoA biosynthetic process|triglyceride biosynthetic process|very long-chain fatty acid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	fatty acid elongase activity|protein binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(4)	7	Lung NSC(77;0.116)					TGTTACTAACTAAAAAAGAAG	0.413000													5	78					0	0	1	0	0
ZBTB39	9880	broad.mit.edu	37	12	57398156	57398156	+	Nonsense_Mutation	SNP	A	A	T			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr12:57398156A>T	ENST00000300101.2	-	2	631	c.546T>A	c.(544-546)taT>taA	p.Y182*		NM_014830.2	NP_055645.1	O15060	ZBT39_HUMAN	zinc finger and BTB domain containing 39	182					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(3)|liver(1)|lung(3)|prostate(1)	16						CTTCCTCTTTATAGCTCCCTC	0.562000													6	372					0	0	1	0	0
ASRGL1	80150	broad.mit.edu	37	11	62123795	62123795	+	Splice_Site	SNP	A	A	T			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr11:62123795A>T	ENST00000415229.2	+	3	405		c.e3-1		ASRGL1_ENST00000301776.5_Splice_Site|ASRGL1_ENST00000535727.1_Intron	NM_001083926.1	NP_001077395.1	Q7L266	ASGL1_HUMAN	asparaginase like 1						asparagine catabolic process via L-aspartate|protein maturation	cytoplasm|microtubule cytoskeleton|nucleus	N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity			endometrium(1)|kidney(1)|lung(1)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	7					L-Asparagine(DB00174)|L-Aspartic Acid(DB00128)	TTTTGGTTTTAGGTTGTGGGT	0.542000													4	114					0	0	1	0	0
MTMR3	8897	broad.mit.edu	37	22	30384486	30384486	+	Missense_Mutation	SNP	A	A	G			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr22:30384486A>G	ENST00000333027.3	+	6	556	c.228A>G	c.(226-228)atA>atG	p.I76M	MTMR3_ENST00000323630.5_5'UTR|MTMR3_ENST00000406629.1_Missense_Mutation_p.I76M|MTMR3_ENST00000401950.2_Missense_Mutation_p.I76M|MTMR3_ENST00000415511.1_Intron|MTMR3_ENST00000351488.3_Missense_Mutation_p.I76M	NM_153050.2|NM_153051.2	NP_694690.1|NP_694691.1	Q13615	MTMR3_HUMAN	myotubularin related protein 3	76					phosphatidylinositol dephosphorylation	cytoplasm|membrane|membrane fraction|nucleus	metal ion binding|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity			breast(3)|large_intestine(3)|ovary(2)|skin(8)|upper_aerodigestive_tract(1)	17			OV - Ovarian serous cystadenocarcinoma(5;0.00204)|Epithelial(10;0.06)|all cancers(5;0.107)			TACAGCTTATAGAAAGTGTTG	0.358000													56	69					0	0	1	0	0
PCDHB3	56132	broad.mit.edu	37	5	140482593	140482593	+	Missense_Mutation	SNP	C	C	A			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr5:140482593C>A	ENST00000231130.2	+	1	2360	c.2360C>A	c.(2359-2361)cCc>cAc	p.P787H		NM_018937.2	NP_061760.1	Q9Y5E6	PCDB3_HUMAN		787					calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			NS(2)|breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(19)|lung(24)|ovary(1)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	72			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GAGGCAAATCCCAGTTTCAGG	0.453000													7	96					1.12685e-05	1.15975e-05	1	1	0
ATP1B4	23439	broad.mit.edu	37	X	119504588	119504588	+	Missense_Mutation	SNP	A	A	T			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chrX:119504588A>T	ENST00000218008.3	+	3	404	c.347A>T	c.(346-348)tAc>tTc	p.Y116F	ATP1B4_ENST00000361319.3_Missense_Mutation_p.Y112F|ATP1B4_ENST00000539306.1_Intron	NM_001142447.2	NP_001135919.1	Q9UN42	AT1B4_HUMAN	ATPase, Na+/K+ transporting, beta 4 polypeptide	116					ATP biosynthetic process|regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to plasma membrane|nuclear inner membrane	sodium:potassium-exchanging ATPase activity			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(3)|lung(14)|ovary(2)|pancreas(1)|skin(4)|upper_aerodigestive_tract(1)	33						TTACTCATTTACTTCTTCTTC	0.483000													5	207					0	0	1	0	0
CCDC181	57821	broad.mit.edu	37	1	169390644	169390644	+	Missense_Mutation	SNP	A	A	T			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr1:169390644A>T	ENST00000545005.1	-	4	1532	c.1025T>A	c.(1024-1026)cTa>cAa	p.L342Q	CCDC181_ENST00000367805.3_Missense_Mutation_p.L342Q|CCDC181_ENST00000367806.3_Missense_Mutation_p.L342Q|CCDC181_ENST00000491570.1_5'UTR					coiled-coil domain containing 181																		TTGTTTTTGTAGTTCTTTCTG	0.363000													4	185					0	0	1	0	0
FAP	2191	broad.mit.edu	37	2	163044875	163044875	+	Splice_Site	SNP	T	T	A			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr2:163044875T>A	ENST00000188790.4	-	20	1827		c.e20-2		FAP_ENST00000443424.1_Splice_Site	NM_004460.2	NP_004451.2	Q12884	SEPR_HUMAN	fibroblast activation protein, alpha						endothelial cell migration|negative regulation of extracellular matrix disassembly|proteolysis	cell junction|integral to membrane|invadopodium membrane|lamellipodium membrane	dipeptidyl-peptidase activity|metalloendopeptidase activity|protein homodimerization activity|serine-type endopeptidase activity	p.?(1)		NS(2)|breast(1)|central_nervous_system(2)|endometrium(5)|kidney(1)|large_intestine(5)|lung(34)|ovary(4)|prostate(3)|skin(2)|upper_aerodigestive_tract(4)	63						CCACCATACCTAAAGGAAAAA	0.383000													5	107					0	0	1	0	0
TCF12	6938	broad.mit.edu	37	15	57355946	57355946	+	Splice_Site	SNP	A	A	T			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr15:57355946A>T	ENST00000267811.5	+	4	452		c.e4-1		TCF12_ENST00000333725.5_Splice_Site|TCF12_ENST00000438423.2_Splice_Site|TCF12_ENST00000452095.2_Intron|TCF12_ENST00000557843.1_Splice_Site	NM_003205.3|NM_207038.1	NP_003196.1|NP_996921.1	Q99081	HTF4_HUMAN	transcription factor 12						immune response|muscle organ development|regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity		TCF12/NR4A3(2)	breast(2)|central_nervous_system(5)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(1)|lung(13)|ovary(2)|prostate(1)|skin(2)|urinary_tract(1)	36		Colorectal(260;0.0907)		all cancers(107;0.000313)|GBM - Glioblastoma multiforme(80;0.00878)|STAD - Stomach adenocarcinoma(283;0.239)		TTCTCTTTTTAGGTATTGATG	0.363000			T	TEC	extraskeletal myxoid chondrosarcoma								11	201					0	0	1	0	0
ANO10	55129	broad.mit.edu	37	3	43642047	43642047	+	Silent	SNP	A	A	G			TCGA-AK-3443-01A-01D-0966-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3dc72bb8-02a6-41b1-a6d6-5c275a82f89b	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr3:43642047A>G	ENST00000292246.3	-	3	336	c.166T>C	c.(166-168)Tta>Cta	p.L56L	ANO10_ENST00000451430.2_Intron|ANO10_ENST00000350459.4_Silent_p.L56L|ANO10_ENST00000414522.2_Silent_p.L56L|ANO10_ENST00000396091.3_Intron	NM_018075.3	NP_060545.3	Q9NW15	ANO10_HUMAN	anoctamin 10	56					cell death	chloride channel complex	chloride channel activity			NS(1)|breast(1)|endometrium(4)|kidney(2)|large_intestine(3)|lung(9)|ovary(3)|prostate(3)|skin(3)	29						TATTTATTTAACAATGGTCTA	0.318000													5	186					0	0	0.184627	0	0
MT-ND1	4535	broad.mit.edu	37	MT	3859	3859	+	Missense_Mutation	SNP	T	T	C			TCGA-AK-3443-01A-01D-0966-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3dc72bb8-02a6-41b1-a6d6-5c275a82f89b	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chrM:3859T>C	ENST00000361390.2	+	1	553	c.553T>C	c.(553-555)Tga>Cga	p.185_185insR						mitochondrially encoded NADH dehydrogenase 1											breast(1)|endometrium(13)|kidney(17)|lung(2)|prostate(1)	34						TGGCCATAATATGATTTATCT	0.478000													492	18					0	0	0.139131	0	0
SOS2	6655	broad.mit.edu	37	14	50626628	50626628	+	Missense_Mutation	SNP	T	T	C			TCGA-AK-3443-01A-01D-0966-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3dc72bb8-02a6-41b1-a6d6-5c275a82f89b	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr14:50626628T>C	ENST00000216373.5	-	10	1647	c.1373A>G	c.(1372-1374)cAt>cGt	p.H458R	SOS2_ENST00000543680.1_Missense_Mutation_p.H425R|SOS2_ENST00000555794.1_5'UTR	NM_006939.2	NP_008870.2	Q07890	SOS2_HUMAN	son of sevenless homolog 2 (Drosophila)	458	PH.				apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	DNA binding|protein binding|Rho guanyl-nucleotide exchange factor activity			cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(13)|lung(16)|ovary(2)|skin(1)	39	all_epithelial(31;0.000822)|Breast(41;0.0065)					CAGAAAAATATGCCGTTCATG	0.388000													154	204					0	0	0.139131	0	0
PKD1L2	114780	broad.mit.edu	37	16	81190482	81190482	+	RNA	SNP	G	G	A			TCGA-AK-3443-01A-01D-0966-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3dc72bb8-02a6-41b1-a6d6-5c275a82f89b	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr16:81190482G>A	ENST00000525539.1	-	0	4106				PKD1L2_ENST00000533478.1_RNA	NM_052892.3	NP_443124.3	Q7Z442	PK1L2_HUMAN	polycystic kidney disease 1-like 2						neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity|sugar binding			breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(20)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	44						GATCCTGAGCGTCCTTCCTCC	0.547000													30	43					0	0	0.153744	0	0
PLA2G6	8398	broad.mit.edu	37	22	38536025	38536025	+	Missense_Mutation	SNP	T	T	G			TCGA-AK-3443-01A-01D-0966-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3dc72bb8-02a6-41b1-a6d6-5c275a82f89b	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr22:38536025T>G	ENST00000332509.3	-	5	944	c.761A>C	c.(760-762)tAc>tCc	p.Y254S	PLA2G6_ENST00000402064.1_Missense_Mutation_p.Y254S|PLA2G6_ENST00000335539.3_Missense_Mutation_p.Y254S	NM_003560.2	NP_003551.2	O60733	PA2G6_HUMAN	phospholipase A2, group VI (cytosolic, calcium-independent)	254					cardiolipin biosynthetic process|cell death|lipid catabolic process	centrosome|membrane		p.Y254S(1)		breast(2)|endometrium(6)|kidney(1)|large_intestine(4)|liver(1)|lung(8)|ovary(1)|upper_aerodigestive_tract(1)	24	Melanoma(58;0.045)				Quinacrine(DB01103)	GTGGATGGGGTAGCCGTTGGG	0.642000													6	14					0	0	0.132662	0	0
LZTS1	11178	broad.mit.edu	37	8	20107349	20107349	+	Missense_Mutation	SNP	G	G	A	rs146878421		TCGA-AK-3443-01A-01D-0966-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3dc72bb8-02a6-41b1-a6d6-5c275a82f89b	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr8:20107349G>A	ENST00000381569.1	-	4	2032	c.1675C>T	c.(1675-1677)Cgc>Tgc	p.R559C	LZTS1_ENST00000522290.1_Missense_Mutation_p.R500C|LZTS1_ENST00000265801.6_Missense_Mutation_p.R559C			Q9Y250	LZTS1_HUMAN	leucine zipper, putative tumor suppressor 1	559					cell cycle|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase III promoter	cell junction|dendritic spine|Golgi apparatus|nucleolus|nucleoplasm|postsynaptic density|postsynaptic membrane	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			breast(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(16)|ovary(2)|skin(1)|urinary_tract(1)	29				Colorectal(74;0.0511)|COAD - Colon adenocarcinoma(73;0.207)		TTCTCCAGGCGCTGGTTCCGC	0.617000													15	220					0	0	0.175082	0	0
MTMR3	8897	broad.mit.edu	37	22	30384486	30384486	+	Missense_Mutation	SNP	A	A	G			TCGA-AK-3443-01A-01D-0966-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3dc72bb8-02a6-41b1-a6d6-5c275a82f89b	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr22:30384486A>G	ENST00000333027.3	+	6	556	c.228A>G	c.(226-228)atA>atG	p.I76M	MTMR3_ENST00000323630.5_5'UTR|MTMR3_ENST00000406629.1_Missense_Mutation_p.I76M|MTMR3_ENST00000415511.1_Intron|MTMR3_ENST00000401950.2_Missense_Mutation_p.I76M|MTMR3_ENST00000351488.3_Missense_Mutation_p.I76M	NM_153050.2|NM_153051.2	NP_694690.1|NP_694691.1	Q13615	MTMR3_HUMAN	myotubularin related protein 3	76					phosphatidylinositol dephosphorylation	cytoplasm|membrane|membrane fraction|nucleus	metal ion binding|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity			breast(3)|large_intestine(3)|ovary(2)|skin(8)|upper_aerodigestive_tract(1)	17			OV - Ovarian serous cystadenocarcinoma(5;0.00204)|Epithelial(10;0.06)|all cancers(5;0.107)			TACAGCTTATAGAAAGTGTTG	0.358000													66	93					0	0	0.139131	0	0
DNM1P47	100216544	broad.mit.edu	37	15	102304869	102304869	+	RNA	SNP	T	T	C	rs139457262	by1000genomes	TCGA-AK-3443-01A-01D-0966-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3dc72bb8-02a6-41b1-a6d6-5c275a82f89b	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr15:102304869T>C	ENST00000561463.1	+	0	12915																											GTCCAACCTGTACTCGCGTGG	0.572000													3	19					0	0	0.115264	0	0
BMP10	27302	broad.mit.edu	37	2	69093688	69093688	+	Missense_Mutation	SNP	G	G	A	rs141935259		TCGA-AK-3443-01A-01D-0966-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3dc72bb8-02a6-41b1-a6d6-5c275a82f89b	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr2:69093688G>A	ENST00000295379.1	-	2	508	c.350C>T	c.(349-351)cCg>cTg	p.P117L		NM_014482.1	NP_055297.1	O95393	BMP10_HUMAN	bone morphogenetic protein 10	117					activin receptor signaling pathway|adult heart development|atrial cardiac muscle tissue morphogenesis|BMP signaling pathway|cardiac muscle cell proliferation|heart trabecula formation|negative regulation of cardiac muscle hypertrophy|negative regulation of cell growth|negative regulation of endothelial cell migration|Notch signaling pathway|pathway-restricted SMAD protein phosphorylation|positive regulation of cardiac muscle cell proliferation|positive regulation of cardiac muscle hypertrophy|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of transcription, DNA-dependent|sarcomere organization|ventricular cardiac muscle cell development|ventricular cardiac muscle tissue morphogenesis	cell surface|extracellular space|Z disc	cytokine activity|growth factor activity|receptor serine/threonine kinase binding	p.P117L(1)		breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(15)|ovary(2)	27						AAAACTGACCGGCTGGGAAAA	0.428000													32	33					0	0	0.153744	0	0
HS3ST2	9956	broad.mit.edu	37	16	22826356	22826356	+	Missense_Mutation	SNP	C	C	T			TCGA-AK-3443-01A-01D-0966-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3dc72bb8-02a6-41b1-a6d6-5c275a82f89b	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr16:22826356C>T	ENST00000261374.3	+	1	859	c.425C>T	c.(424-426)gCc>gTc	p.A142V		NM_006043.1	NP_006034.1	Q9Y278	HS3S2_HUMAN	heparan sulfate (glucosamine) 3-O-sulfotransferase 2	142						Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine 3-sulfotransferase 2 activity			breast(2)|kidney(1)|large_intestine(5)|liver(2)|lung(5)|ovary(1)|pancreas(2)|skin(1)	19				GBM - Glioblastoma multiforme(48;0.0299)		GACGTGCGGGCCTTGGGCACG	0.647000													22	35					0	0	0.076483	0	0
GPS1	2873	broad.mit.edu	37	17	80014617	80014617	+	Missense_Mutation	SNP	G	G	A			TCGA-AK-3443-01A-01D-0966-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3dc72bb8-02a6-41b1-a6d6-5c275a82f89b	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr17:80014617G>A	ENST00000392358.2	+	11	1698	c.1349G>A	c.(1348-1350)aGt>aAt	p.S450N	GPS1_ENST00000578552.1_Missense_Mutation_p.S410N|GPS1_ENST00000306823.6_Missense_Mutation_p.S414N|GPS1_ENST00000320548.4_Missense_Mutation_p.S394N|GPS1_ENST00000355130.2_Missense_Mutation_p.S450N	NM_212492.1	NP_997657.1	Q13098	CSN1_HUMAN	G protein pathway suppressor 1	414					cell cycle|cullin deneddylation|inactivation of MAPK activity|JNK cascade	cytoplasm|signalosome	GTPase inhibitor activity|protein binding			breast(1)|central_nervous_system(1)|endometrium(3)|liver(1)|lung(4)|prostate(1)|skin(2)	13	all_neural(118;0.0878)|Ovarian(332;0.227)|all_lung(278;0.246)		BRCA - Breast invasive adenocarcinoma(99;0.0114)|OV - Ovarian serous cystadenocarcinoma(97;0.0211)			GGGCTGATCAGTGCCCGTGTG	0.657000													4	30					0	0	0.150653	0	0
SPEG	10290	broad.mit.edu	37	2	220307861	220307861	+	Missense_Mutation	SNP	G	G	A			TCGA-AK-3443-01A-01D-0966-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3dc72bb8-02a6-41b1-a6d6-5c275a82f89b	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr2:220307861G>A	ENST00000396698.1	+	2	71	c.65G>A	c.(64-66)cGa>cAa	p.R22Q	SPEG_ENST00000396695.2_5'UTR|SPEG_ENST00000312358.7_Intron			Q15772	SPEG_HUMAN	SPEG complex locus	0					muscle organ development|negative regulation of cell proliferation	nucleus	ATP binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(3)|endometrium(10)|kidney(2)|large_intestine(9)|lung(42)|ovary(5)|pancreas(1)|prostate(8)|skin(1)|stomach(9)|upper_aerodigestive_tract(4)|urinary_tract(4)	100		Renal(207;0.0183)		Epithelial(149;4.5e-10)|all cancers(144;7.93e-08)|Lung(261;0.00639)|LUSC - Lung squamous cell carcinoma(224;0.00829)|READ - Rectum adenocarcinoma(5;0.163)		GCCTTTGGCCGACTCACCCAT	0.587000													147	248					0	0	0.139131	0	0
CHRM4	1132	broad.mit.edu	37	11	46407118	46407118	+	Silent	SNP	C	C	T			TCGA-AK-3443-01A-01D-0966-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3dc72bb8-02a6-41b1-a6d6-5c275a82f89b	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr11:46407118C>T	ENST00000433765.2	-	1	989	c.990G>A	c.(988-990)ccG>ccA	p.P330P		NM_000741.2	NP_000732.2	P08173	ACM4_HUMAN	cholinergic receptor, muscarinic 4	330					cell proliferation	cell junction|integral to plasma membrane|postsynaptic membrane	muscarinic acetylcholine receptor activity			breast(1)|endometrium(7)|kidney(1)|large_intestine(1)|lung(6)|prostate(3)|skin(1)	20				GBM - Glioblastoma multiforme(35;0.0254)|Lung(87;0.14)	Atropine(DB00572)|Benzquinamide(DB00767)|Cryptenamine(DB00785)|Homatropine Methylbromide(DB00725)|Methotrimeprazine(DB01403)|Metixene(DB00340)|Olanzapine(DB00334)|Procyclidine(DB00387)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Thiethylperazine(DB00372)|Tropicamide(DB00809)	TGAGGGCCCGCGGCTGCAGGG	0.637000													11	313					0	0	0.080935	0	0
PCDHB3	56132	broad.mit.edu	37	5	140482593	140482593	+	Missense_Mutation	SNP	C	C	A			TCGA-AK-3443-01A-01D-0966-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3dc72bb8-02a6-41b1-a6d6-5c275a82f89b	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr5:140482593C>A	ENST00000231130.2	+	1	2360	c.2360C>A	c.(2359-2361)cCc>cAc	p.P787H		NM_018937.2	NP_061760.1	Q9Y5E6	PCDB3_HUMAN		787					calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			NS(2)|breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(19)|lung(24)|ovary(1)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	72			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GAGGCAAATCCCAGTTTCAGG	0.453000													14	196					2.23348e-06	3.19069e-06	0.146539	1	0
N4BP2	55728	broad.mit.edu	37	4	40123308	40123308	+	Missense_Mutation	SNP	A	A	T			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	e9f65a55-337b-4a82-a85a-b0f9a68f599d	g.chr4:40123308A>T	ENST00000261435.6	+	9	3993	c.3577A>T	c.(3577-3579)Act>Tct	p.T1193S		NM_018177.4	NP_060647.2	Q86UW6	N4BP2_HUMAN	NEDD4 binding protein 2	1193						cytoplasm	ATP binding|ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity|endonuclease activity|protein binding			breast(4)|endometrium(3)|kidney(12)|large_intestine(7)|liver(2)|lung(22)|ovary(1)|pancreas(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(1)	60						CTCACAGTCTACTTGTGATGC	0.423000													4	150					0	0	1	0	0
ANO10	55129	broad.mit.edu	37	3	43642047	43642047	+	Silent	SNP	A	A	G			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	e9f65a55-337b-4a82-a85a-b0f9a68f599d	g.chr3:43642047A>G	ENST00000292246.3	-	3	336	c.166T>C	c.(166-168)Tta>Cta	p.L56L	ANO10_ENST00000350459.4_Silent_p.L56L|ANO10_ENST00000396091.3_Intron|ANO10_ENST00000414522.2_Silent_p.L56L|ANO10_ENST00000451430.2_Intron	NM_018075.3	NP_060545.3	Q9NW15	ANO10_HUMAN	anoctamin 10	56					cell death	chloride channel complex	chloride channel activity			NS(1)|breast(1)|endometrium(4)|kidney(2)|large_intestine(3)|lung(9)|ovary(3)|prostate(3)|skin(3)	29						TATTTATTTAACAATGGTCTA	0.318000													4	149					0	0	1	0	0
DNAH3	55567	broad.mit.edu	37	16	20990695	20990695	+	Missense_Mutation	SNP	C	C	T			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	e9f65a55-337b-4a82-a85a-b0f9a68f599d	g.chr16:20990695C>T	ENST00000261383.3	-	50	8032	c.8033G>A	c.(8032-8034)cGc>cAc	p.R2678H	DNAH3_ENST00000415178.1_3'UTR	NM_017539.1	NP_060009.1	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	2678	Stalk (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(3)|autonomic_ganglia(1)|breast(12)|central_nervous_system(3)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(42)|liver(2)|lung(57)|ovary(14)|pancreas(1)|prostate(7)|skin(11)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(6)	202				GBM - Glioblastoma multiforme(48;0.207)		TGTCAGGTAGCGGTTCCTCAT	0.512000													4	89					0	0	1	0	0
TAAR9	134860	broad.mit.edu	37	6	132859788	132859788	+	RNA	SNP	A	A	T			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	e9f65a55-337b-4a82-a85a-b0f9a68f599d	g.chr6:132859788A>T	ENST00000434551.1	+	0	360					NM_175057.3	NP_778227.3	Q96RI9	TAAR9_HUMAN	trace amine associated receptor 9 (gene/pseudogene)							plasma membrane	G-protein coupled receptor activity					Breast(56;0.112)			OV - Ovarian serous cystadenocarcinoma(155;0.0042)|GBM - Glioblastoma multiforme(226;0.00816)		TTGCTTCTTTATTTCATTTAT	0.403000													5	177					0	0	1	0	0
ST6GALNAC1	55808	broad.mit.edu	37	17	74622001	74622001	+	Splice_Site	SNP	C	C	T			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	e9f65a55-337b-4a82-a85a-b0f9a68f599d	g.chr17:74622001C>T	ENST00000156626.7	-	8	1705		c.e8-1			NM_018414.3	NP_060884.1	Q9NSC7	SIA7A_HUMAN	ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1						protein glycosylation	integral to Golgi membrane	alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity			breast(2)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(11)|prostate(1)|upper_aerodigestive_tract(1)	22						CCTCAGAAACCTGTGAAATGC	0.567000													3	97					0	0	1	0	0
IGFBP5	3488	broad.mit.edu	37	2	217541537	217541537	+	Silent	SNP	T	T	C			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	e9f65a55-337b-4a82-a85a-b0f9a68f599d	g.chr2:217541537T>C	ENST00000233813.4	-	4	1505	c.756A>G	c.(754-756)ccA>ccG	p.P252P		NM_000599.3	NP_000590.1	P24593	IBP5_HUMAN	insulin-like growth factor binding protein 5	252	Thyroglobulin type-1.				negative regulation of insulin-like growth factor receptor signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of smooth muscle cell proliferation|negative regulation of translation|signal transduction		insulin-like growth factor I binding			endometrium(1)|large_intestine(3)|lung(1)	5		Renal(323;0.0822)		Epithelial(149;2.1e-06)|all cancers(144;0.000165)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		ACTCCATGCCTGGCAGCTTCA	0.607000													4	365					0	0	1	0	0
WDR65	149465	broad.mit.edu	37	1	43650987	43650987	+	Missense_Mutation	SNP	T	T	A			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	e9f65a55-337b-4a82-a85a-b0f9a68f599d	g.chr1:43650987T>A	ENST00000372492.4	+	5	1253	c.929T>A	c.(928-930)aTg>aAg	p.M310K	WDR65_ENST00000528956.1_Missense_Mutation_p.M310K	NM_001195831.2	NP_001182760.2	Q96MR6	WDR65_HUMAN	WD repeat domain 65	310										NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(7)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	23	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				TTTGAGAAGATGGAAGAAAAG	0.478000													5	142					0	0	1	0	0
NPIPA5	100288332	broad.mit.edu	37	16	15457701	15457701	+	Missense_Mutation	SNP	G	G	A			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	e9f65a55-337b-4a82-a85a-b0f9a68f599d	g.chr16:15457701G>A	ENST00000360151.4	-	8	867	c.868C>T	c.(868-870)Ctc>Ttc	p.L290F		NM_001277325.1	NP_001264254.1			nuclear pore complex interacting protein family, member A5									p.L290F(2)									AGGGGAGTGAGCAGACACTCG	0.562000													5	134					0	0	1	0	0
SOS2	6655	broad.mit.edu	37	14	50626628	50626628	+	Missense_Mutation	SNP	T	T	C			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	e9f65a55-337b-4a82-a85a-b0f9a68f599d	g.chr14:50626628T>C	ENST00000216373.5	-	10	1647	c.1373A>G	c.(1372-1374)cAt>cGt	p.H458R	SOS2_ENST00000543680.1_Missense_Mutation_p.H425R|SOS2_ENST00000555794.1_5'UTR	NM_006939.2	NP_008870.2	Q07890	SOS2_HUMAN	son of sevenless homolog 2 (Drosophila)	458	PH.				apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	DNA binding|protein binding|Rho guanyl-nucleotide exchange factor activity			cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(13)|lung(16)|ovary(2)|skin(1)	39	all_epithelial(31;0.000822)|Breast(41;0.0065)					CAGAAAAATATGCCGTTCATG	0.388000													90	140					0	0	1	0	0
PKD1L2	114780	broad.mit.edu	37	16	81190482	81190482	+	RNA	SNP	G	G	A			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	e9f65a55-337b-4a82-a85a-b0f9a68f599d	g.chr16:81190482G>A	ENST00000533478.1	-	0	2162				PKD1L2_ENST00000525539.1_RNA	NM_001278425.1	NP_001265354.1	Q7Z442	PK1L2_HUMAN	polycystic kidney disease 1-like 2						neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity|sugar binding			breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(20)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	44						GATCCTGAGCGTCCTTCCTCC	0.547000													13	19					0	0	1	0	0
TRGV5	6978	broad.mit.edu	37	7	38389495	38389495	+	RNA	SNP	C	C	A	rs2012300	by1000genomes	TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	e9f65a55-337b-4a82-a85a-b0f9a68f599d	g.chr7:38389495C>A	ENST00000390344.2	-	0	128																											CTTAAAACTCCGGCCCCACTC	0.542000													5	22					0.00198382	0.00210781	1	1	0
TTN	7273	broad.mit.edu	37	2	179614538	179614538	+	Missense_Mutation	SNP	C	C	T			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	e9f65a55-337b-4a82-a85a-b0f9a68f599d	g.chr2:179614538C>T	ENST00000360870.5	-	46	12811	c.12589G>A	c.(12589-12591)Gtc>Atc	p.V4197I	TTN-AS1_ENST00000578746.1_RNA|TTN_ENST00000460472.2_Intron|TTN_ENST00000342175.6_Intron|TTN_ENST00000342992.6_Intron|TTN-AS1_ENST00000590773.1_RNA|TTN_ENST00000359218.5_Intron|TTN_ENST00000589042.1_Intron|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000591111.1_Intron	NM_133379.3	NP_596870.2	Q8WZ42	TITIN_HUMAN	titin	3541							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTTAAAAGGACTCCATTTTGA	0.363000													3	83					0	0	1	0	0
MCC	4163	broad.mit.edu	37	5	112363128	112363128	+	Silent	SNP	C	C	T			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	e9f65a55-337b-4a82-a85a-b0f9a68f599d	g.chr5:112363128C>T	ENST00000302475.4	-	17	2924	c.2361G>A	c.(2359-2361)ctG>ctA	p.L787L	MCC_ENST00000515367.2_Silent_p.L724L|MCC_ENST00000514701.3_5'UTR|MCC_ENST00000408903.3_Silent_p.L977L	NM_002387.2	NP_002378.1	P23508	CRCM_HUMAN	mutated in colorectal cancers	787					negative regulation of canonical Wnt receptor signaling pathway|negative regulation of epithelial cell migration|negative regulation of epithelial cell proliferation|Wnt receptor signaling pathway	cytoplasm|nucleus|plasma membrane	protein binding|receptor activity			endometrium(4)|kidney(3)|large_intestine(15)|liver(2)|lung(8)|ovary(2)|pancreas(1)|prostate(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	42		all_cancers(142;5.89e-08)|all_epithelial(76;3.57e-11)|all_lung(232;0.000605)|Lung NSC(810;0.000697)|Colorectal(10;0.00146)|Prostate(80;0.00174)|Ovarian(225;0.0175)|Breast(839;0.198)		OV - Ovarian serous cystadenocarcinoma(64;2.04e-54)|Epithelial(69;9.69e-49)|all cancers(49;6.25e-44)|COAD - Colon adenocarcinoma(37;0.0432)|Colorectal(14;0.0766)		CTAACTTCTTCAGTTTGTTTT	0.448000													4	235					0	0	1	0	0
MTMR3	8897	broad.mit.edu	37	22	30384486	30384486	+	Missense_Mutation	SNP	A	A	G			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	e9f65a55-337b-4a82-a85a-b0f9a68f599d	g.chr22:30384486A>G	ENST00000333027.3	+	6	556	c.228A>G	c.(226-228)atA>atG	p.I76M	MTMR3_ENST00000406629.1_Missense_Mutation_p.I76M|MTMR3_ENST00000401950.2_Missense_Mutation_p.I76M|MTMR3_ENST00000415511.1_Intron|MTMR3_ENST00000323630.5_5'UTR|MTMR3_ENST00000351488.3_Missense_Mutation_p.I76M	NM_153050.2|NM_153051.2	NP_694690.1|NP_694691.1	Q13615	MTMR3_HUMAN	myotubularin related protein 3	76					phosphatidylinositol dephosphorylation	cytoplasm|membrane|membrane fraction|nucleus	metal ion binding|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity			breast(3)|large_intestine(3)|ovary(2)|skin(8)|upper_aerodigestive_tract(1)	17			OV - Ovarian serous cystadenocarcinoma(5;0.00204)|Epithelial(10;0.06)|all cancers(5;0.107)			TACAGCTTATAGAAAGTGTTG	0.358000													56	69					0	0	1	0	0
CKAP2L	150468	broad.mit.edu	37	2	113500345	113500345	+	Splice_Site	SNP	G	G	A			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	e9f65a55-337b-4a82-a85a-b0f9a68f599d	g.chr2:113500345G>A	ENST00000541405.1	-	7	1788	c.1263_splice	c.e7-1	p.P422_splice	NT5DC4_ENST00000327581.4_3'UTR|CKAP2L_ENST00000302450.6_Splice_Site_p.P587_splice			Q8IYA6	CKP2L_HUMAN	cytoskeleton associated protein 2-like	587						centrosome				breast(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(15)|skin(1)|upper_aerodigestive_tract(1)	28						CTCTTGTATTGGCTGGAAGGA	0.294000													3	32					0	0	1	0	0
CNNM2	54805	broad.mit.edu	37	10	104836767	104836767	+	Missense_Mutation	SNP	C	C	T			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	e9f65a55-337b-4a82-a85a-b0f9a68f599d	g.chr10:104836767C>T	ENST00000369878.3	+	8	2582	c.2458C>T	c.(2458-2460)Cgg>Tgg	p.R820W	CNNM2_ENST00000433628.2_Missense_Mutation_p.R798W|CNNM2_ENST00000457502.2_Missense_Mutation_p.R578W|CNNM2_ENST00000475511.1_3'UTR	NM_017649.4	NP_060119.3	Q9H8M5	CNNM2_HUMAN	cyclin M2	820					ion transport	integral to membrane				central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(7)|ovary(1)|prostate(2)|urinary_tract(1)	19		Colorectal(252;0.103)|all_hematologic(284;0.152)|Breast(234;0.198)		Epithelial(162;7.89e-09)|all cancers(201;1.82e-07)|BRCA - Breast invasive adenocarcinoma(275;0.215)		GATGGCATCCCGGATGGACAA	0.463000													6	96					0	0	1	0	0
KIF5A	3798	broad.mit.edu	37	12	57957964	57957964	+	Missense_Mutation	SNP	C	C	G			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	e9f65a55-337b-4a82-a85a-b0f9a68f599d	g.chr12:57957964C>G	ENST00000455537.2	+	4	639	c.365C>G	c.(364-366)tCc>tGc	p.S122C	KIF5A_ENST00000286452.5_Intron	NM_004984.2	NP_004975.2	Q12840	KIF5A_HUMAN	kinesin family member 5A	122	Kinesin-motor.				blood coagulation|cell death|microtubule-based movement|synaptic transmission	cytosol|kinesin complex|membrane fraction|microtubule|perinuclear region of cytoplasm	ATP binding|microtubule motor activity			breast(2)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(11)|liver(1)|lung(32)|ovary(2)|prostate(2)|skin(2)	62						CACATCTACTCCATGGATGAG	0.517000													3	95					0	0	1	0	0
BMP10	27302	broad.mit.edu	37	2	69093688	69093688	+	Missense_Mutation	SNP	G	G	A	rs141935259		TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	e9f65a55-337b-4a82-a85a-b0f9a68f599d	g.chr2:69093688G>A	ENST00000295379.1	-	2	508	c.350C>T	c.(349-351)cCg>cTg	p.P117L		NM_014482.1	NP_055297.1	O95393	BMP10_HUMAN	bone morphogenetic protein 10	117					activin receptor signaling pathway|adult heart development|atrial cardiac muscle tissue morphogenesis|BMP signaling pathway|cardiac muscle cell proliferation|heart trabecula formation|negative regulation of cardiac muscle hypertrophy|negative regulation of cell growth|negative regulation of endothelial cell migration|Notch signaling pathway|pathway-restricted SMAD protein phosphorylation|positive regulation of cardiac muscle cell proliferation|positive regulation of cardiac muscle hypertrophy|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of transcription, DNA-dependent|sarcomere organization|ventricular cardiac muscle cell development|ventricular cardiac muscle tissue morphogenesis	cell surface|extracellular space|Z disc	cytokine activity|growth factor activity|receptor serine/threonine kinase binding	p.P117L(1)		breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(15)|ovary(2)	27						AAAACTGACCGGCTGGGAAAA	0.428000													21	26					0	0	1	0	0
ATP1B4	23439	broad.mit.edu	37	X	119504588	119504588	+	Missense_Mutation	SNP	A	A	T			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	e9f65a55-337b-4a82-a85a-b0f9a68f599d	g.chrX:119504588A>T	ENST00000218008.3	+	3	404	c.347A>T	c.(346-348)tAc>tTc	p.Y116F	ATP1B4_ENST00000539306.1_Intron|ATP1B4_ENST00000361319.3_Missense_Mutation_p.Y112F	NM_001142447.2	NP_001135919.1	Q9UN42	AT1B4_HUMAN	ATPase, Na+/K+ transporting, beta 4 polypeptide	116					ATP biosynthetic process|regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to plasma membrane|nuclear inner membrane	sodium:potassium-exchanging ATPase activity			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(3)|lung(14)|ovary(2)|pancreas(1)|skin(4)|upper_aerodigestive_tract(1)	33						TTACTCATTTACTTCTTCTTC	0.483000													5	207					0	0	1	0	0
TAF7L	54457	broad.mit.edu	37	X	100536765	100536765	+	Splice_Site	SNP	T	T	A			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	e9f65a55-337b-4a82-a85a-b0f9a68f599d	g.chrX:100536765T>A	ENST00000372907.3	-	6	676		c.e6-2		TAF7L_ENST00000372905.2_Splice_Site|TAF7L_ENST00000324762.6_Splice_Site|TAF7L_ENST00000356784.1_Splice_Site	NM_024885.3	NP_079161.3	Q5H9L4	TAF7L_HUMAN	TAF7-like RNA polymerase II, TATA box binding protein (TBP)-associated factor, 50kDa						cell differentiation|multicellular organismal development|regulation of transcription, DNA-dependent|spermatogenesis|transcription initiation from RNA polymerase II promoter	cytoplasm|transcription factor TFIID complex	binding			NS(1)|breast(4)|kidney(4)|large_intestine(4)|lung(7)|ovary(1)|pancreas(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	29						GTGGCGTAACTAAAATAAATA	0.373000													4	65					0	0	1	0	0
PCNT	5116	broad.mit.edu	37	21	47754527	47754527	+	Missense_Mutation	SNP	A	A	G			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	e9f65a55-337b-4a82-a85a-b0f9a68f599d	g.chr21:47754527A>G	ENST00000359568.5	+	3	591	c.484A>G	c.(484-486)Agt>Ggt	p.S162G	PCNT_ENST00000480896.1_3'UTR	NM_006031.5	NP_006022.3	O95613	PCNT_HUMAN	pericentrin	162					cilium assembly|G2/M transition of mitotic cell cycle	cytosol|microtubule	calmodulin binding			NS(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(15)|liver(2)|lung(41)|ovary(5)|pancreas(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	104	Breast(49;0.112)					GTTCACAGTCAGTGACCACCC	0.552000													6	246					0	0	1	0	0
GPAM	57678	broad.mit.edu	37	10	113915654	113915654	+	Missense_Mutation	SNP	A	A	T			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	e9f65a55-337b-4a82-a85a-b0f9a68f599d	g.chr10:113915654A>T	ENST00000348367.4	-	20	2476	c.2279T>A	c.(2278-2280)aTa>aAa	p.I760K	GPAM_ENST00000369425.1_3'UTR|GPAM_ENST00000423155.1_Missense_Mutation_p.I760K			Q9HCL2	GPAT1_HUMAN	glycerol-3-phosphate acyltransferase, mitochondrial	760					phospholipid biosynthetic process|triglyceride biosynthetic process	integral to membrane|mitochondrial outer membrane	glycerol-3-phosphate O-acyltransferase activity			breast(2)|central_nervous_system(2)|endometrium(8)|kidney(2)|large_intestine(5)|lung(8)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	31				Epithelial(162;0.0306)|all cancers(201;0.123)		TGTTCTGGTTATTAGGTATTT	0.353000													4	102					0	0	1	0	0
TSGA10	80705	broad.mit.edu	37	2	99689497	99689497	+	Missense_Mutation	SNP	T	T	C			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	e9f65a55-337b-4a82-a85a-b0f9a68f599d	g.chr2:99689497T>C	ENST00000393483.3	-	13	1766	c.922A>G	c.(922-924)Atg>Gtg	p.M308V	TSGA10_ENST00000542655.1_Intron|TSGA10_ENST00000410001.1_Missense_Mutation_p.M308V|TSGA10_ENST00000478090.1_5'UTR|TSGA10_ENST00000539964.1_Missense_Mutation_p.M308V|TSGA10_ENST00000355053.4_Missense_Mutation_p.M308V	NM_025244.2	NP_079520.1	Q9BZW7	TSG10_HUMAN	testis specific, 10	308					spermatogenesis	cytoplasm|nuclear membrane				NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(10)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	34						GCCTGTTCCATCTCAGCAATG	0.338000													4	162					0	0	1	0	0
HS3ST2	9956	broad.mit.edu	37	16	22826356	22826356	+	Missense_Mutation	SNP	C	C	T			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	e9f65a55-337b-4a82-a85a-b0f9a68f599d	g.chr16:22826356C>T	ENST00000261374.3	+	1	859	c.425C>T	c.(424-426)gCc>gTc	p.A142V		NM_006043.1	NP_006034.1	Q9Y278	HS3S2_HUMAN	heparan sulfate (glucosamine) 3-O-sulfotransferase 2	142						Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine 3-sulfotransferase 2 activity			breast(2)|kidney(1)|large_intestine(5)|liver(2)|lung(5)|ovary(1)|pancreas(2)|skin(1)	19				GBM - Glioblastoma multiforme(48;0.0299)		GACGTGCGGGCCTTGGGCACG	0.647000													14	24					0	0	1	0	0
COG3	83548	broad.mit.edu	37	13	46054373	46054373	+	Missense_Mutation	SNP	C	C	A			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	e9f65a55-337b-4a82-a85a-b0f9a68f599d	g.chr13:46054373C>A	ENST00000349995.5	+	4	609	c.497C>A	c.(496-498)tCc>tAc	p.S166Y		NM_031431.3	NP_113619.2	Q96JB2	COG3_HUMAN	component of oligomeric golgi complex 3	166					ER to Golgi vesicle-mediated transport|intra-Golgi vesicle-mediated transport|intracellular protein transport|protein glycosylation|protein localization to organelle|protein stabilization|retrograde vesicle-mediated transport, Golgi to ER	cis-Golgi network|Golgi cisterna membrane|Golgi transport complex	protein binding|protein transporter activity			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(8)|prostate(2)|skin(2)|stomach(1)	24		Lung NSC(96;0.000145)|Breast(56;0.000596)|Prostate(109;0.00438)|Hepatocellular(98;0.0207)|Lung SC(185;0.0262)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;0.000124)		CTTTTTGTGTCCAATAAGACA	0.378000													3	67					0.115264	0.119969	1	1	0
RRBP1	6238	broad.mit.edu	37	20	17595443	17595443	+	Missense_Mutation	SNP	T	T	C			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	e9f65a55-337b-4a82-a85a-b0f9a68f599d	g.chr20:17595443T>C	ENST00000377813.1	-	24	4436	c.4133A>G	c.(4132-4134)cAg>cGg	p.Q1378R	RRBP1_ENST00000468428.1_5'UTR|RRBP1_ENST00000455029.2_Missense_Mutation_p.Q719R|RRBP1_ENST00000246043.4_Missense_Mutation_p.Q1378R|RRBP1_ENST00000377807.2_Missense_Mutation_p.Q945R|RRBP1_ENST00000360807.4_Missense_Mutation_p.Q945R			Q9P2E9	RRBP1_HUMAN	ribosome binding protein 1	1378					protein transport|translation|transmembrane transport	integral to endoplasmic reticulum membrane|ribosome	receptor activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(9)|ovary(2)|prostate(6)	28						CAGCTGCTCCTGGGTCGTCTT	0.582000													3	48					0	0	1	0	0
TFIP11	24144	broad.mit.edu	37	22	26888109	26888109	+	Missense_Mutation	SNP	C	C	T			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	e9f65a55-337b-4a82-a85a-b0f9a68f599d	g.chr22:26888109C>T	ENST00000407690.1	-	15	2667	c.2384G>A	c.(2383-2385)cGa>cAa	p.R795Q	TFIP11_ENST00000407431.1_Missense_Mutation_p.R795Q|TFIP11_ENST00000407148.1_Missense_Mutation_p.R795Q|TFIP11_ENST00000405938.1_Missense_Mutation_p.R795Q	NM_012143.2	NP_036275.1	Q9UBB9	TFP11_HUMAN	tuftelin interacting protein 11	795					biomineral tissue development	catalytic step 2 spliceosome|cytoplasm|nuclear speck	DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(5)|kidney(2)|large_intestine(5)|liver(1)|lung(7)|prostate(2)|skin(1)|urinary_tract(1)	25						CCCTTCGTGTCGCTTCCCAAT	0.557000													4	80					0	0	1	0	0
PRSS16	10279	broad.mit.edu	37	6	27215757	27215757	+	Missense_Mutation	SNP	T	T	C			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	e9f65a55-337b-4a82-a85a-b0f9a68f599d	g.chr6:27215757T>C	ENST00000230582.3	+	2	182	c.167T>C	c.(166-168)cTc>cCc	p.L56P	PRSS16_ENST00000421826.2_Missense_Mutation_p.L56P	NM_005865.3	NP_005856.1	Q9NQE7	TSSP_HUMAN	protease, serine, 16 (thymus)	56					protein catabolic process|proteolysis	cytoplasmic membrane-bounded vesicle	serine-type peptidase activity			central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(5)|lung(9)|ovary(3)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	26						GCTGCAGCCCTCCCAAAAGTG	0.632000													3	118					0	0	1	0	0
ZNF845	91664	broad.mit.edu	37	19	53856702	53856702	+	Missense_Mutation	SNP	G	G	A	rs150688663	by1000genomes	TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	e9f65a55-337b-4a82-a85a-b0f9a68f599d	g.chr19:53856702G>A	ENST00000458035.1	+	4	2891	c.2774G>A	c.(2773-2775)cGt>cAt	p.R925H	ZNF845_ENST00000595091.1_Missense_Mutation_p.R925H	NM_138374.1	NP_612383.1	Q96IR2	ZN845_HUMAN	zinc finger protein 845	925					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.R925H(3)		endometrium(2)|kidney(10)|lung(7)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|urinary_tract(2)	26						AAAACCTTCCGTCACAATTCA	0.363000													3	31					0	0	1	0	0
CHD7	55636	broad.mit.edu	37	8	61654168	61654168	+	Silent	SNP	T	T	A			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	e9f65a55-337b-4a82-a85a-b0f9a68f599d	g.chr8:61654168T>A	ENST00000423902.2	+	2	656	c.177T>A	c.(175-177)acT>acA	p.T59T	CHD7_ENST00000524602.1_Silent_p.T59T|CHD7_ENST00000525508.1_Silent_p.T59T	NM_017780.3	NP_060250.2	Q9P2D1	CHD7_HUMAN	chromodomain helicase DNA binding protein 7	59					central nervous system development|chromatin modification|cognition|cranial nerve development|face development|heart morphogenesis|in utero embryonic development|inner ear morphogenesis|nose development|palate development|regulation of growth hormone secretion|regulation of transcription, DNA-dependent|retina development in camera-type eye|skeletal system development|T cell differentiation|transcription, DNA-dependent	nucleus	ATP binding|chromatin binding|DNA binding|helicase activity			NS(1)|breast(6)|central_nervous_system(8)|cervix(2)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(16)|lung(49)|ovary(4)|pancreas(2)|prostate(4)|skin(2)|urinary_tract(3)	123		all_cancers(86;0.2)|all_lung(136;0.0402)|Lung NSC(129;0.0459)|all_epithelial(80;0.0477)	BRCA - Breast invasive adenocarcinoma(89;0.143)			ATCCTTCAACTAATCAAAATC	0.398000													3	44					0	0	1	0	0
SENP2	59343	broad.mit.edu	37	3	185324122	185324122	+	Missense_Mutation	SNP	A	A	T			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	e9f65a55-337b-4a82-a85a-b0f9a68f599d	g.chr3:185324122A>T	ENST00000296257.5	+	6	694	c.454A>T	c.(454-456)Act>Tct	p.T152S	SENP2_ENST00000427465.2_5'UTR|SENP2_ENST00000465201.1_3'UTR|SENP2_ENST00000545472.1_Missense_Mutation_p.T142S	NM_021627.2	NP_067640.2	Q9HC62	SENP2_HUMAN	SUMO1/sentrin/SMT3 specific peptidase 2	152					mRNA transport|protein desumoylation|protein transport|proteolysis|regulation of Wnt receptor signaling pathway|transmembrane transport|Wnt receptor signaling pathway	cytoplasm|nuclear membrane|nuclear pore	protein binding|SUMO-specific protease activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(5)|skin(3)	12	all_cancers(143;1.28e-10)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(80;1.31e-21)			GCTCAGTTTTACTTTGAACTC	0.413000													4	87					0	0	1	0	0
PSMD1	5707	broad.mit.edu	37	2	232035330	232035330	+	Silent	SNP	G	G	A			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	e9f65a55-337b-4a82-a85a-b0f9a68f599d	g.chr2:232035330G>A	ENST00000308696.6	+	24	2928	c.2766G>A	c.(2764-2766)gaG>gaA	p.E922E	PSMD1_ENST00000409643.1_Silent_p.E891E|PSMD1_ENST00000373635.4_Silent_p.E891E	NM_002807.3	NP_002798.2	Q99460	PSMD1_HUMAN	proteasome (prosome, macropain) 26S subunit, non-ATPase, 1	922					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|regulation of protein catabolic process|S phase of mitotic cell cycle|viral reproduction	proteasome regulatory particle	enzyme regulator activity|protein binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(10)|lung(10)|ovary(1)|prostate(1)|skin(4)	31		Ovarian(221;0.000626)|Medulloblastoma(418;0.0109)|Renal(207;0.0112)|Lung NSC(271;0.0538)|all_lung(227;0.0713)|all_hematologic(139;0.0748)|Acute lymphoblastic leukemia(138;0.167)		Epithelial(121;4e-26)|LUSC - Lung squamous cell carcinoma(224;0.0138)|Lung(119;0.0168)	Bortezomib(DB00188)	AAGACATTGAGGAGCTGGTGG	0.493000													3	104					0	0	1	0	0
BOD1L1	259282	broad.mit.edu	37	4	13603058	13603058	+	Silent	SNP	C	C	T			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	e9f65a55-337b-4a82-a85a-b0f9a68f599d	g.chr4:13603058C>T	ENST00000040738.5	-	10	5601	c.5466G>A	c.(5464-5466)tcG>tcA	p.S1822S		NM_148894.2	NP_683692.2	Q8NFC6	BOD1L_HUMAN	biorientation of chromosomes in cell division 1-like 1	1822							DNA binding										CATTTTCTTCCGATTCAGAAC	0.488000													4	201					0	0	1	0	0
TBC1D23	55773	broad.mit.edu	37	3	100016854	100016854	+	Missense_Mutation	SNP	G	G	A			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	e9f65a55-337b-4a82-a85a-b0f9a68f599d	g.chr3:100016854G>A	ENST00000394144.4	+	9	971	c.964G>A	c.(964-966)Gtg>Atg	p.V322M	TBC1D23_ENST00000475134.1_Missense_Mutation_p.V185M|TBC1D23_ENST00000344949.5_Missense_Mutation_p.V322M|TBC1D23_ENST00000486274.1_3'UTR	NM_001199198.2	NP_001186127.1	Q9NUY8	TBC23_HUMAN	TBC1 domain family, member 23	322						intracellular	Rab GTPase activator activity			breast(1)|endometrium(1)|large_intestine(7)|liver(1)|lung(10)|ovary(1)|prostate(2)|skin(2)	25						GGCCATCTCCGTGTCAGAGAT	0.433000													3	58					0	0	1	0	0
SPEG	10290	broad.mit.edu	37	2	220307861	220307861	+	Missense_Mutation	SNP	G	G	A			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	e9f65a55-337b-4a82-a85a-b0f9a68f599d	g.chr2:220307861G>A	ENST00000396698.1	+	2	71	c.65G>A	c.(64-66)cGa>cAa	p.R22Q	SPEG_ENST00000312358.7_Intron|SPEG_ENST00000396695.2_5'UTR			Q15772	SPEG_HUMAN	SPEG complex locus	0					muscle organ development|negative regulation of cell proliferation	nucleus	ATP binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(3)|endometrium(10)|kidney(2)|large_intestine(9)|lung(42)|ovary(5)|pancreas(1)|prostate(8)|skin(1)|stomach(9)|upper_aerodigestive_tract(4)|urinary_tract(4)	100		Renal(207;0.0183)		Epithelial(149;4.5e-10)|all cancers(144;7.93e-08)|Lung(261;0.00639)|LUSC - Lung squamous cell carcinoma(224;0.00829)|READ - Rectum adenocarcinoma(5;0.163)		GCCTTTGGCCGACTCACCCAT	0.587000													130	159					0	0	1	0	0
ZNF845	91664	broad.mit.edu	37	19	53856730	53856730	+	Silent	SNP	G	G	A			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	e9f65a55-337b-4a82-a85a-b0f9a68f599d	g.chr19:53856730G>A	ENST00000458035.1	+	4	2919	c.2802G>A	c.(2800-2802)aaG>aaA	p.K934K	ZNF845_ENST00000595091.1_Silent_p.K934K	NM_138374.1	NP_612383.1	Q96IR2	ZN845_HUMAN	zinc finger protein 845	934					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.K934K(3)		endometrium(2)|kidney(10)|lung(7)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|urinary_tract(2)	26						TAATTCATAAGACAATTCATA	0.368000													3	23					0	0	1	0	0
PDP2	57546	broad.mit.edu	37	16	66919031	66919031	+	Missense_Mutation	SNP	G	G	A			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	e9f65a55-337b-4a82-a85a-b0f9a68f599d	g.chr16:66919031G>A	ENST00000311765.2	+	2	1178	c.844G>A	c.(844-846)Gca>Aca	p.A282T	PDP2_ENST00000568720.1_Intron	NM_020786.2	NP_065837.1	Q9P2J9	PDP2_HUMAN	pyruvate dehyrogenase phosphatase catalytic subunit 2	282					pyruvate metabolic process|regulation of acetyl-CoA biosynthetic process from pyruvate	mitochondrial matrix|protein serine/threonine phosphatase complex	[pyruvate dehydrogenase (lipoamide)] phosphatase activity|metal ion binding			kidney(1)|large_intestine(2)|lung(6)|ovary(1)|prostate(1)|urinary_tract(1)	12		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.088)|Epithelial(162;0.204)		CTTGCACGTGGCAAATGCTGG	0.552000													3	104					0	0	1	0	0
PCDHB3	56132	broad.mit.edu	37	5	140482593	140482593	+	Missense_Mutation	SNP	C	C	A			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	e9f65a55-337b-4a82-a85a-b0f9a68f599d	g.chr5:140482593C>A	ENST00000231130.2	+	1	2360	c.2360C>A	c.(2359-2361)cCc>cAc	p.P787H		NM_018937.2	NP_061760.1	Q9Y5E6	PCDB3_HUMAN		787					calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			NS(2)|breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(19)|lung(24)|ovary(1)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	72			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GAGGCAAATCCCAGTTTCAGG	0.453000													7	96					1.12685e-05	1.22275e-05	1	1	0
EP300	2033	broad.mit.edu	37	22	41566408	41566408	+	Splice_Site	SNP	A	A	T			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	e9f65a55-337b-4a82-a85a-b0f9a68f599d	g.chr22:41566408A>T	ENST00000263253.7	+	27	5505		c.e27-1		RP1-85F18.6_ENST00000415054.1_RNA	NM_001429.3	NP_001420.2	Q09472	EP300_HUMAN	E1A binding protein p300						apoptosis|cell cycle|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|histone H4 acetylation|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of androgen receptor signaling pathway|response to estrogen stimulus|response to hypoxia	centrosome|histone acetyltransferase complex	androgen receptor binding|beta-catenin binding|DNA binding|histone acetyltransferase activity|RNA polymerase II activating transcription factor binding|transcription coactivator activity|zinc ion binding			NS(2)|breast(11)|central_nervous_system(7)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(31)|kidney(5)|large_intestine(31)|liver(2)|lung(33)|ovary(2)|pancreas(4)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(16)	171						TTGTATTGTTAGTTACACAAC	0.383000			"""T,  N, F, Mis, O"""	"""MLL, RUNXBP2"""	"""colorectal, breast, pancreatic, AML, ALL, DLBCL"""				Rubinstein-Taybi syndrome				4	117					0	0	1	0	0
HMGN2P46	283651	broad.mit.edu	37	15	45848217	45848217	+	RNA	SNP	A	A	G			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	e9f65a55-337b-4a82-a85a-b0f9a68f599d	g.chr15:45848217A>G	ENST00000409454.1	+	0	1212																											ATAAAAATGCAGATTTTGTTT	0.313000													3	41					0	0	1	0	0
ANO10	55129	broad.mit.edu	37	3	43642047	43642047	+	Silent	SNP	A	A	G			TCGA-AK-3443-01A-01D-0966-08	TCGA-AK-3443-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3dc72bb8-02a6-41b1-a6d6-5c275a82f89b	e9f65a55-337b-4a82-a85a-b0f9a68f599d	g.chr3:43642047A>G	ENST00000292246.3	-	3	336	c.166T>C	c.(166-168)Tta>Cta	p.L56L	ANO10_ENST00000414522.2_Silent_p.L56L|ANO10_ENST00000451430.2_Intron|ANO10_ENST00000350459.4_Silent_p.L56L|ANO10_ENST00000396091.3_Intron	NM_018075.3	NP_060545.3	Q9NW15	ANO10_HUMAN	anoctamin 10	56					cell death	chloride channel complex	chloride channel activity			NS(1)|breast(1)|endometrium(4)|kidney(2)|large_intestine(3)|lung(9)|ovary(3)|prostate(3)|skin(3)	29						TATTTATTTAACAATGGTCTA	0.318000													5	186					0	0	0.184627	0	0
SOS2	6655	broad.mit.edu	37	14	50626628	50626628	+	Missense_Mutation	SNP	T	T	C			TCGA-AK-3443-01A-01D-0966-08	TCGA-AK-3443-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3dc72bb8-02a6-41b1-a6d6-5c275a82f89b	e9f65a55-337b-4a82-a85a-b0f9a68f599d	g.chr14:50626628T>C	ENST00000216373.5	-	10	1647	c.1373A>G	c.(1372-1374)cAt>cGt	p.H458R	SOS2_ENST00000543680.1_Missense_Mutation_p.H425R|SOS2_ENST00000555794.1_5'UTR	NM_006939.2	NP_008870.2	Q07890	SOS2_HUMAN	son of sevenless homolog 2 (Drosophila)	458	PH.				apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	DNA binding|protein binding|Rho guanyl-nucleotide exchange factor activity			cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(13)|lung(16)|ovary(2)|skin(1)	39	all_epithelial(31;0.000822)|Breast(41;0.0065)					CAGAAAAATATGCCGTTCATG	0.388000													154	204					0	0	0.139131	0	0
TRGV5	6978	broad.mit.edu	37	7	38389495	38389495	+	RNA	SNP	C	C	A	rs2012300	by1000genomes	TCGA-AK-3443-01A-01D-0966-08	TCGA-AK-3443-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3dc72bb8-02a6-41b1-a6d6-5c275a82f89b	e9f65a55-337b-4a82-a85a-b0f9a68f599d	g.chr7:38389495C>A	ENST00000390344.2	-	0	128																											CTTAAAACTCCGGCCCCACTC	0.542000													5	13					3.59834e-05	4.94771e-05	0.217242	1	0
LZTS1	11178	broad.mit.edu	37	8	20107349	20107349	+	Missense_Mutation	SNP	G	G	A	rs146878421		TCGA-AK-3443-01A-01D-0966-08	TCGA-AK-3443-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3dc72bb8-02a6-41b1-a6d6-5c275a82f89b	e9f65a55-337b-4a82-a85a-b0f9a68f599d	g.chr8:20107349G>A	ENST00000381569.1	-	4	2032	c.1675C>T	c.(1675-1677)Cgc>Tgc	p.R559C	LZTS1_ENST00000522290.1_Missense_Mutation_p.R500C|LZTS1_ENST00000265801.6_Missense_Mutation_p.R559C			Q9Y250	LZTS1_HUMAN	leucine zipper, putative tumor suppressor 1	559					cell cycle|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase III promoter	cell junction|dendritic spine|Golgi apparatus|nucleolus|nucleoplasm|postsynaptic density|postsynaptic membrane	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			breast(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(16)|ovary(2)|skin(1)|urinary_tract(1)	29				Colorectal(74;0.0511)|COAD - Colon adenocarcinoma(73;0.207)		TTCTCCAGGCGCTGGTTCCGC	0.617000													15	220					0	0	0.175082	0	0
MTMR3	8897	broad.mit.edu	37	22	30384486	30384486	+	Missense_Mutation	SNP	A	A	G			TCGA-AK-3443-01A-01D-0966-08	TCGA-AK-3443-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3dc72bb8-02a6-41b1-a6d6-5c275a82f89b	e9f65a55-337b-4a82-a85a-b0f9a68f599d	g.chr22:30384486A>G	ENST00000333027.3	+	6	556	c.228A>G	c.(226-228)atA>atG	p.I76M	MTMR3_ENST00000415511.1_Intron|MTMR3_ENST00000351488.3_Missense_Mutation_p.I76M|MTMR3_ENST00000323630.5_5'UTR|MTMR3_ENST00000406629.1_Missense_Mutation_p.I76M|MTMR3_ENST00000401950.2_Missense_Mutation_p.I76M	NM_153050.2|NM_153051.2	NP_694690.1|NP_694691.1	Q13615	MTMR3_HUMAN	myotubularin related protein 3	76					phosphatidylinositol dephosphorylation	cytoplasm|membrane|membrane fraction|nucleus	metal ion binding|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity			breast(3)|large_intestine(3)|ovary(2)|skin(8)|upper_aerodigestive_tract(1)	17			OV - Ovarian serous cystadenocarcinoma(5;0.00204)|Epithelial(10;0.06)|all cancers(5;0.107)			TACAGCTTATAGAAAGTGTTG	0.358000													66	93					0	0	0.139131	0	0
BMP10	27302	broad.mit.edu	37	2	69093688	69093688	+	Missense_Mutation	SNP	G	G	A	rs141935259		TCGA-AK-3443-01A-01D-0966-08	TCGA-AK-3443-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3dc72bb8-02a6-41b1-a6d6-5c275a82f89b	e9f65a55-337b-4a82-a85a-b0f9a68f599d	g.chr2:69093688G>A	ENST00000295379.1	-	2	508	c.350C>T	c.(349-351)cCg>cTg	p.P117L		NM_014482.1	NP_055297.1	O95393	BMP10_HUMAN	bone morphogenetic protein 10	117					activin receptor signaling pathway|adult heart development|atrial cardiac muscle tissue morphogenesis|BMP signaling pathway|cardiac muscle cell proliferation|heart trabecula formation|negative regulation of cardiac muscle hypertrophy|negative regulation of cell growth|negative regulation of endothelial cell migration|Notch signaling pathway|pathway-restricted SMAD protein phosphorylation|positive regulation of cardiac muscle cell proliferation|positive regulation of cardiac muscle hypertrophy|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of transcription, DNA-dependent|sarcomere organization|ventricular cardiac muscle cell development|ventricular cardiac muscle tissue morphogenesis	cell surface|extracellular space|Z disc	cytokine activity|growth factor activity|receptor serine/threonine kinase binding	p.P117L(1)		breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(15)|ovary(2)	27						AAAACTGACCGGCTGGGAAAA	0.428000													32	33					0	0	0.153744	0	0
PKD1L2	114780	broad.mit.edu	37	16	81190482	81190482	+	RNA	SNP	G	G	A			TCGA-AK-3443-01A-01D-0966-08	TCGA-AK-3443-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3dc72bb8-02a6-41b1-a6d6-5c275a82f89b	e9f65a55-337b-4a82-a85a-b0f9a68f599d	g.chr16:81190482G>A	ENST00000533478.1	-	0	2162				PKD1L2_ENST00000525539.1_RNA	NM_001278425.1	NP_001265354.1	Q7Z442	PK1L2_HUMAN	polycystic kidney disease 1-like 2						neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity|sugar binding			breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(20)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	44						GATCCTGAGCGTCCTTCCTCC	0.547000													30	43					0	0	0.153744	0	0
HS3ST2	9956	broad.mit.edu	37	16	22826356	22826356	+	Missense_Mutation	SNP	C	C	T			TCGA-AK-3443-01A-01D-0966-08	TCGA-AK-3443-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3dc72bb8-02a6-41b1-a6d6-5c275a82f89b	e9f65a55-337b-4a82-a85a-b0f9a68f599d	g.chr16:22826356C>T	ENST00000261374.3	+	1	859	c.425C>T	c.(424-426)gCc>gTc	p.A142V		NM_006043.1	NP_006034.1	Q9Y278	HS3S2_HUMAN	heparan sulfate (glucosamine) 3-O-sulfotransferase 2	142						Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine 3-sulfotransferase 2 activity			breast(2)|kidney(1)|large_intestine(5)|liver(2)|lung(5)|ovary(1)|pancreas(2)|skin(1)	19				GBM - Glioblastoma multiforme(48;0.0299)		GACGTGCGGGCCTTGGGCACG	0.647000													22	35					0	0	0.076483	0	0
SPEG	10290	broad.mit.edu	37	2	220307861	220307861	+	Missense_Mutation	SNP	G	G	A			TCGA-AK-3443-01A-01D-0966-08	TCGA-AK-3443-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3dc72bb8-02a6-41b1-a6d6-5c275a82f89b	e9f65a55-337b-4a82-a85a-b0f9a68f599d	g.chr2:220307861G>A	ENST00000396698.1	+	2	71	c.65G>A	c.(64-66)cGa>cAa	p.R22Q	SPEG_ENST00000396695.2_5'UTR|SPEG_ENST00000312358.7_Intron			Q15772	SPEG_HUMAN	SPEG complex locus	0					muscle organ development|negative regulation of cell proliferation	nucleus	ATP binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(3)|endometrium(10)|kidney(2)|large_intestine(9)|lung(42)|ovary(5)|pancreas(1)|prostate(8)|skin(1)|stomach(9)|upper_aerodigestive_tract(4)|urinary_tract(4)	100		Renal(207;0.0183)		Epithelial(149;4.5e-10)|all cancers(144;7.93e-08)|Lung(261;0.00639)|LUSC - Lung squamous cell carcinoma(224;0.00829)|READ - Rectum adenocarcinoma(5;0.163)		GCCTTTGGCCGACTCACCCAT	0.587000													147	248					0	0	0.139131	0	0
CHRM4	1132	broad.mit.edu	37	11	46407118	46407118	+	Silent	SNP	C	C	T			TCGA-AK-3443-01A-01D-0966-08	TCGA-AK-3443-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3dc72bb8-02a6-41b1-a6d6-5c275a82f89b	e9f65a55-337b-4a82-a85a-b0f9a68f599d	g.chr11:46407118C>T	ENST00000433765.2	-	1	989	c.990G>A	c.(988-990)ccG>ccA	p.P330P		NM_000741.2	NP_000732.2	P08173	ACM4_HUMAN	cholinergic receptor, muscarinic 4	330					cell proliferation	cell junction|integral to plasma membrane|postsynaptic membrane	muscarinic acetylcholine receptor activity			breast(1)|endometrium(7)|kidney(1)|large_intestine(1)|lung(6)|prostate(3)|skin(1)	20				GBM - Glioblastoma multiforme(35;0.0254)|Lung(87;0.14)	Atropine(DB00572)|Benzquinamide(DB00767)|Cryptenamine(DB00785)|Homatropine Methylbromide(DB00725)|Methotrimeprazine(DB01403)|Metixene(DB00340)|Olanzapine(DB00334)|Procyclidine(DB00387)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Thiethylperazine(DB00372)|Tropicamide(DB00809)	TGAGGGCCCGCGGCTGCAGGG	0.637000													11	313					0	0	0.080935	0	0
FOXO3	2309	broad.mit.edu	37	6	108984910	108984910	+	Missense_Mutation	SNP	C	C	T			TCGA-AK-3443-01A-01D-0966-08	TCGA-AK-3443-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3dc72bb8-02a6-41b1-a6d6-5c275a82f89b	e9f65a55-337b-4a82-a85a-b0f9a68f599d	g.chr6:108984910C>T	ENST00000406360.1	+	2	1217	c.874C>T	c.(874-876)Cct>Tct	p.P292S	FOXO3_ENST00000343882.6_Missense_Mutation_p.P292S|FOXO3_ENST00000540898.1_Missense_Mutation_p.P72S	NM_001455.3	NP_001446.1	O43524	FOXO3_HUMAN	forkhead box O3	292				PGSPTSRSSDELDAWTDFRSRTNSNASTVSGRLSPIMAS -> AWQPHVNAAVMSWMRGRTSVHAPILTPAQSVAACRPSW QV (in Ref. 5; CAA04860).	antral ovarian follicle growth|apoptosis|embryo development|glucose homeostasis|induction of apoptosis|initiation of primordial ovarian follicle growth|insulin receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|nerve growth factor receptor signaling pathway|oocyte maturation|ovulation from ovarian follicle|pattern specification process|phosphatidylinositol-mediated signaling|positive regulation of erythrocyte differentiation|positive regulation of transcription from RNA polymerase II promoter|regulation of cell proliferation|regulation of sequence-specific DNA binding transcription factor activity|tissue development	cytosol|transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|protein kinase binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription factor binding			central_nervous_system(5)|endometrium(1)|kidney(1)|large_intestine(2)|lung(6)|ovary(2)|prostate(4)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	26		all_cancers(87;1.78e-07)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;3.88e-05)|Colorectal(196;0.0294)|all_lung(197;0.0487)|Lung SC(18;0.152)		Epithelial(106;0.000759)|all cancers(137;0.00121)|BRCA - Breast invasive adenocarcinoma(108;0.00163)|OV - Ovarian serous cystadenocarcinoma(136;0.00718)		CTCCAAGTGGCCTGGCAGCCC	0.622000													4	44					0	0	0.150653	0	0
PCDHB3	56132	broad.mit.edu	37	5	140482593	140482593	+	Missense_Mutation	SNP	C	C	A			TCGA-AK-3443-01A-01D-0966-08	TCGA-AK-3443-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3dc72bb8-02a6-41b1-a6d6-5c275a82f89b	e9f65a55-337b-4a82-a85a-b0f9a68f599d	g.chr5:140482593C>A	ENST00000231130.2	+	1	2360	c.2360C>A	c.(2359-2361)cCc>cAc	p.P787H		NM_018937.2	NP_061760.1	Q9Y5E6	PCDB3_HUMAN		787					calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			NS(2)|breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(19)|lung(24)|ovary(1)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	72			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GAGGCAAATCCCAGTTTCAGG	0.453000													14	196					2.23348e-06	3.35023e-06	0.146539	1	0
SSU72	29101	broad.mit.edu	37	1	1500119	1500120	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr1:1500119_1500120insG	ENST00000359060.4	-	2	283_284	c.257_258insC	c.(256-258)ctgfs	p.L86fs	SSU72_ENST00000291386.3_Intron			Q9NP77	SSU72_HUMAN	SSU72 RNA polymerase II CTD phosphatase homolog (S. cerevisiae)	0					mRNA processing	cytoplasm|nucleus	phosphoprotein phosphatase activity			large_intestine(2)|lung(5)	7	all_cancers(77;0.00125)|all_epithelial(69;0.000703)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;5.03e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;5.04e-37)|OV - Ovarian serous cystadenocarcinoma(86;3.72e-23)|GBM - Glioblastoma multiforme(42;1.2e-07)|Colorectal(212;0.000188)|COAD - Colon adenocarcinoma(227;0.000214)|Kidney(185;0.00254)|STAD - Stomach adenocarcinoma(132;0.00645)|BRCA - Breast invasive adenocarcinoma(365;0.00837)|KIRC - Kidney renal clear cell carcinoma(229;0.037)|Lung(427;0.205)		GAGGACCACACGGGGGGTTTTT	0.505													7	304	---	---	---	---					
AGO1	26523	broad.mit.edu	37	1	36354044	36354045	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr1:36354044_36354045insC	ENST00000373204.4	+	2	255_256	c.42_43insC	c.(40-45)ctccccfs	p.LP14fs	AGO1_ENST00000373206.1_5'UTR	NM_012199.2	NP_036331.1			argonaute RISC catalytic component 1																		GCGCTTACCTGCCCCCCCTGCA	0.569													8	178	---	---	---	---					
ZMYND12	84217	broad.mit.edu	37	1	42898878	42898879	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr1:42898878_42898879insG	ENST00000372565.3	-	7	1179_1180	c.910_911insC	c.(910-912)aaafs	p.K304fs	ZMYND12_ENST00000475426.1_5'UTR|ZMYND12_ENST00000433602.2_Frame_Shift_Ins_p.K194fs	NM_032257.4	NP_115633.3	Q9H0C1	ZMY12_HUMAN	zinc finger, MYND-type containing 12	304						intracellular	zinc ion binding			NS(1)|endometrium(2)|large_intestine(3)|lung(5)|ovary(2)|prostate(2)|skin(2)	17	Ovarian(52;0.00744)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				GATGGTTTTTTGGGGGGCTTTG	0.411													8	357	---	---	---	---					
FAM151A	338094	broad.mit.edu	37	1	55081756	55081757	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr1:55081756_55081757insG	ENST00000302250.2	-	3	511_512	c.351_352insC	c.(349-354)ccctatfs	p.Y118fs	ACOT11_ENST00000371316.3_Intron|FAM151A_ENST00000371304.2_Frame_Shift_Ins_p.Y118fs	NM_176782.2	NP_788954.2	Q8WW52	F151A_HUMAN	family with sequence similarity 151, member A	118						integral to membrane		p.T118fs*43(1)		breast(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(2)|ovary(1)|stomach(1)|upper_aerodigestive_tract(1)	12						CTGTAGATAGTGGGGGGGTGTG	0.594													9	237	---	---	---	---					
FGGY	55277	broad.mit.edu	37	1	59812016	59812017	+	Frame_Shift_Ins	INS	-	-	G	rs145440779	by1000genomes	TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr1:59812016_59812017insG	ENST00000371218.4	+	4	595_596	c.411_412insG	c.(409-414)gtggggfs	p.VG137fs	FGGY_ENST00000303721.7_Frame_Shift_Ins_p.VG137fs|FGGY_ENST00000371212.1_Intron|FGGY_ENST00000474476.1_3'UTR	NM_001113411.1	NP_001106882.1	Q96C11	FGGY_HUMAN	FGGY carbohydrate kinase domain containing	137					carbohydrate metabolic process|cell death|neuron homeostasis		kinase activity|phosphotransferase activity, alcohol group as acceptor			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(13)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	22	all_cancers(7;7.36e-05)					TCCAGTACGTCGGGGGGGTGAT	0.500													16	155	---	---	---	---					
GBP7	388646	broad.mit.edu	37	1	89613321	89613322	+	Frame_Shift_Ins	INS	-	-	C	rs138127555		TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr1:89613321_89613322insC	ENST00000294671.2	-	8	1431_1432	c.1293_1294insG	c.(1291-1296)ggacaafs	p.Q432fs		NM_207398.2	NP_997281.2	Q8N8V2	GBP7_HUMAN	guanylate binding protein 7	432						integral to membrane	GTP binding|GTPase activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(2)|large_intestine(9)|lung(5)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	27		Lung NSC(277;0.0908)		all cancers(265;0.00835)|Epithelial(280;0.0322)		TAGATATTGTGCCCCCCCGGAA	0.436													11	160	---	---	---	---					
EPHX4	253152	broad.mit.edu	37	1	92511121	92511122	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr1:92511121_92511122insG	ENST00000370383.4	+	4	606_607	c.508_509insG	c.(508-510)gggfs	p.G170fs		NM_173567.4	NP_775838.3	Q8IUS5	EPHX4_HUMAN	epoxide hydrolase 4	170						integral to membrane	hydrolase activity			central_nervous_system(1)|large_intestine(3)|lung(8)	12						TGGCCATGACTGGGGGGGCATG	0.386													20	258	---	---	---	---					
OVGP1	5016	broad.mit.edu	37	1	111959046	111959047	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr1:111959046_111959047insC	ENST00000369732.3	-	10	1109_1110	c.1054_1055insG	c.(1054-1056)catfs	p.H352fs	OVGP1_ENST00000540696.1_3'UTR	NM_002557.3	NP_002548.3	Q12889	OVGP1_HUMAN	oviductal glycoprotein 1, 120kDa	352					chitin catabolic process|female pregnancy|single fertilization	transport vesicle	cation binding|chitinase activity			NS(1)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(13)|ovary(4)|prostate(1)|skin(4)|stomach(3)|urinary_tract(1)	39		all_cancers(81;8.18e-06)|all_epithelial(167;5.64e-06)|all_lung(203;0.000152)|Lung NSC(277;0.000302)		Lung(183;0.0253)|Colorectal(144;0.033)|all cancers(265;0.0552)|Epithelial(280;0.0802)|COAD - Colon adenocarcinoma(174;0.123)|LUSC - Lung squamous cell carcinoma(189;0.14)		CCACACCATGGCCCCCCCAAAA	0.505													26	349	---	---	---	---					
ITGA10	8515	broad.mit.edu	37	1	145534121	145534122	+	Frame_Shift_Ins	INS	-	-	C	rs147270843		TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr1:145534121_145534122insC	ENST00000369304.3	+	14	1801_1802	c.1626_1627insC	c.(1624-1629)gaccccfs	p.DP542fs	ITGA10_ENST00000538811.1_Frame_Shift_Ins_p.DP411fs|ITGA10_ENST00000539363.1_Frame_Shift_Ins_p.DP399fs	NM_003637.3	NP_003628.2	O75578	ITA10_HUMAN	integrin, alpha 10	542					cell-matrix adhesion|integrin-mediated signaling pathway	integrin complex	collagen binding|receptor activity			NS(1)|breast(2)|endometrium(3)|kidney(5)|large_intestine(12)|lung(25)|ovary(2)|prostate(3)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	59	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					TTCAGCCAGAACCCCCCCAGGA	0.554													18	329	---	---	---	---					
PIAS3	10401	broad.mit.edu	37	1	145585532	145585533	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr1:145585532_145585533insG	ENST00000393045.2	+	14	1887_1888	c.1797_1798insG	c.(1795-1800)ccggggfs	p.PG599fs	PIAS3_ENST00000369298.1_Frame_Shift_Ins_p.PG564fs	NM_006099.3	NP_006090.2	Q9Y6X2	PIAS3_HUMAN	protein inhibitor of activated STAT, 3	599					positive regulation of protein sumoylation|protein sumoylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear speck	enzyme binding|nucleic acid binding|protein C-terminus binding|zinc ion binding			cervix(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(14)|ovary(1)|prostate(2)	28	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					TTGTGGCCCCTGGGGGGGCCTT	0.663													8	108	---	---	---	---					
SCAMP3	10067	broad.mit.edu	37	1	155230128	155230129	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr1:155230128_155230129insC	ENST00000355379.3	-	3	580_581	c.302_303insG	c.(301-303)gacfs	p.D101fs	SCAMP3_ENST00000302631.3_Frame_Shift_Ins_p.D127fs|SCAMP3_ENST00000472397.1_5'UTR	NM_052837.2	NP_443069.1	O14828	SCAM3_HUMAN	secretory carrier membrane protein 3	127					post-Golgi vesicle-mediated transport|protein transport	integral to membrane				breast(1)|endometrium(3)|large_intestine(3)|lung(7)|ovary(4)|urinary_tract(1)	19	all_lung(78;2.32e-23)|Hepatocellular(266;0.0877)|all_hematologic(923;0.088)		Epithelial(20;3.72e-10)|all cancers(21;1.19e-09)|BRCA - Breast invasive adenocarcinoma(34;0.000752)|LUSC - Lung squamous cell carcinoma(543;0.193)			TACTAGCTGTGCCCCCCAGGGC	0.589													9	249	---	---	---	---					
NES	10763	broad.mit.edu	37	1	156642803	156642804	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr1:156642803_156642804insG	ENST00000368223.3	-	4	1308_1309	c.1176_1177insC	c.(1174-1179)cccaccfs	p.T393fs		NM_006617.1	NP_006608.1	P48681	NEST_HUMAN	nestin	393	Tail.				brain development|embryonic camera-type eye development|G2/M transition of mitotic cell cycle|negative regulation of apoptosis|positive regulation of intermediate filament depolymerization|positive regulation of neural precursor cell proliferation|stem cell proliferation	cytoplasm|intermediate filament	intermediate filament binding|structural molecule activity			central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(30)|ovary(6)|prostate(1)|skin(3)|stomach(1)|urinary_tract(4)	64	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					GCCTGAGGTGTGGGGGGGATGG	0.594													7	119	---	---	---	---					
MRPL24	79590	broad.mit.edu	37	1	156708444	156708445	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr1:156708444_156708445insG	ENST00000361531.2	-	2	188_189	c.52_53insC	c.(52-54)ttafs	p.L18fs	MRPL24_ENST00000368211.4_Frame_Shift_Ins_p.L18fs			Q96A35	RM24_HUMAN	mitochondrial ribosomal protein L24	18					translation	mitochondrion|ribosome	structural constituent of ribosome			endometrium(1)|large_intestine(1)|lung(4)	6	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					ATAGCGGTAATGGGGGGGCAGA	0.574													8	121	---	---	---	---					
KCNJ10	3766	broad.mit.edu	37	1	160012017	160012018	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr1:160012017_160012018insG	ENST00000368089.3	-	2	531_532	c.305_306insC	c.(304-306)cgcfs	p.R102fs	KCNJ10_ENST00000509700.1_5'UTR	NM_002241.4	NP_002232.2	P78508	IRK10_HUMAN	potassium inwardly-rectifying channel, subfamily J, member 10	102						integral to plasma membrane	ATP binding|ATP-activated inward rectifier potassium channel activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(7)|ovary(1)|prostate(1)	17	all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			TGTGGTTGGCCGGGGGGTCCAG	0.584													7	306	---	---	---	---					
PAPPA2	60676	broad.mit.edu	37	1	176762723	176762724	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr1:176762723_176762724insC	ENST00000367662.3	+	20	6212_6213	c.5048_5049insC	c.(5047-5049)accfs	p.T1683fs		NM_020318.2	NP_064714.2	Q9BXP8	PAPP2_HUMAN	pappalysin 2	1683	Sushi 5.				cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			NS(3)|breast(3)|central_nervous_system(7)|cervix(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(19)|lung(136)|ovary(7)|pancreas(1)|prostate(4)|skin(10)|upper_aerodigestive_tract(8)|urinary_tract(1)	226						TTGTGTGTAATCCCCCCCAGTG	0.470													12	307	---	---	---	---					
FAM129A	116496	broad.mit.edu	37	1	184764537	184764538	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr1:184764537_184764538insC	ENST00000367511.3	-	14	2553_2554	c.2360_2361insG	c.(2359-2361)gttfs	p.V787fs	FAM129A_ENST00000487074.1_5'UTR	NM_052966.2	NP_443198.1	Q9BZQ8	NIBAN_HUMAN	family with sequence similarity 129, member A	787	Glu-rich.				negative regulation of protein phosphorylation|positive regulation of protein phosphorylation|positive regulation of translation|response to endoplasmic reticulum stress	cytoplasm|nucleus|plasma membrane				autonomic_ganglia(1)|breast(1)|cervix(2)|endometrium(4)|large_intestine(6)|liver(1)|lung(22)|ovary(3)|skin(3)|upper_aerodigestive_tract(2)	45						CCTCTGGAAATCCCCCCAACTC	0.668													7	398	---	---	---	---					
CACNA1S	779	broad.mit.edu	37	1	201046125	201046126	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr1:201046125_201046126insC	ENST00000362061.3	-	12	1975_1976	c.1749_1750insG	c.(1747-1752)ggggtafs	p.V584fs	CACNA1S_ENST00000367338.3_Frame_Shift_Ins_p.V584fs	NM_000069.2	NP_000060.2	Q13698	CAC1S_HUMAN	calcium channel, voltage-dependent, L type, alpha 1S subunit	584					axon guidance	I band|T-tubule|voltage-gated calcium channel complex	high voltage-gated calcium channel activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(13)|large_intestine(19)|lung(37)|ovary(6)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	102					Magnesium Sulfate(DB00653)|Verapamil(DB00661)	AAGTCATACCTCCCCCCAAAGA	0.574													7	295	---	---	---	---					
ATP2B4	493	broad.mit.edu	37	1	203667345	203667346	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr1:203667345_203667346insC	ENST00000357681.5	+	3	1377_1378	c.254_255insC	c.(253-255)accfs	p.T85fs	ATP2B4_ENST00000391954.2_Frame_Shift_Ins_p.T85fs|ATP2B4_ENST00000367218.3_Frame_Shift_Ins_p.T85fs|ATP2B4_ENST00000341360.2_Frame_Shift_Ins_p.T85fs|ATP2B4_ENST00000367219.3_Frame_Shift_Ins_p.T85fs	NM_001684.4	NP_001675.3	P23634	AT2B4_HUMAN	ATPase, Ca++ transporting, plasma membrane 4	85					ATP biosynthetic process|platelet activation	integral to plasma membrane	ATP binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding|protein binding			NS(1)|breast(1)|central_nervous_system(2)|cervix(2)|endometrium(5)|kidney(2)|large_intestine(10)|lung(20)|ovary(2)|prostate(6)|skin(1)|stomach(1)|urinary_tract(3)	56	all_cancers(21;0.071)|all_epithelial(62;0.228)		BRCA - Breast invasive adenocarcinoma(75;0.109)			CACAACGTGATCCCCCCCAAAA	0.480													7	168	---	---	---	---					
PIK3C2B	5287	broad.mit.edu	37	1	204438071	204438072	+	Frame_Shift_Ins	INS	-	-	G	rs115574296	by1000genomes	TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr1:204438071_204438072insG	ENST00000367187.3	-	3	1415_1416	c.859_860insC	c.(859-861)cacfs	p.H287fs	PIK3C2B_ENST00000424712.2_Frame_Shift_Ins_p.H287fs	NM_002646.3	NP_002637.3	O00750	P3C2B_HUMAN	phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta	287	Interaction with GRB2.				cell communication|phosphatidylinositol-mediated signaling	endoplasmic reticulum|microsome|nucleus|phosphatidylinositol 3-kinase complex|plasma membrane	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity|protein binding	p.R287fs*92(1)		breast(3)|central_nervous_system(1)|cervix(2)|endometrium(4)|large_intestine(11)|lung(24)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	52	all_cancers(21;0.00347)|all_neural(3;0.0218)|Glioma(3;0.0382)|all_epithelial(62;0.171)|Breast(84;0.179)|Prostate(682;0.227)		GBM - Glioblastoma multiforme(2;2.69e-45)|all cancers(3;1.66e-30)|KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.143)|Epithelial(59;0.193)			GGCATAGGTGCGGGGGGGCACC	0.624													16	240	---	---	---	---					
DIEXF	27042	broad.mit.edu	37	1	210014266	210014267	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr1:210014266_210014267insC	ENST00000491415.2	+	8	1408_1409	c.1351_1352insC	c.(1351-1353)cccfs	p.P451fs		NM_014388.6	NP_055203.4	Q68CQ4	DIEXF_HUMAN	digestive organ expansion factor homolog (zebrafish)	451					multicellular organismal development	nucleus				breast(6)|central_nervous_system(2)|cervix(2)|endometrium(2)|kidney(15)|large_intestine(7)|lung(12)|ovary(1)|skin(3)|stomach(1)|urinary_tract(2)	53						CCTCATTGCTTCCCCCCTGGGC	0.465													7	284	---	---	---	---					
MYT1L	23040	broad.mit.edu	37	2	1947094	1947094	+	Frame_Shift_Del	DEL	A	A	-			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr2:1947094delA	ENST00000399161.2	-	9	912	c.165delT	c.(163-165)tgfs	p.C55fs	MYT1L_ENST00000428368.2_Frame_Shift_Del_p.C55fs	NM_015025.2	NP_055840.2	Q9UL68	MYT1L_HUMAN	myelin transcription factor 1-like	55					cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(6)|large_intestine(16)|lung(50)|ovary(5)|prostate(2)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	97	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.037)|all_epithelial(98;0.241)		OV - Ovarian serous cystadenocarcinoma(76;0.169)|all cancers(51;0.244)		TCGCCAAGGGACAACCATATA	0.418													2	4	---	---	---	---					
AGBL5	60509	broad.mit.edu	37	2	27292516	27292517	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr2:27292516_27292517insC	ENST00000360131.4	+	14	2590_2591	c.2431_2432insC	c.(2431-2433)cccfs	p.P811fs		NM_021831.5	NP_068603.4	Q8NDL9	CBPC5_HUMAN	ATP/GTP binding protein-like 5	811					protein branching point deglutamylation|proteolysis	cytosol|nucleus	metallocarboxypeptidase activity|tubulin binding|zinc ion binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|large_intestine(5)|lung(8)|ovary(3)|pancreas(1)|prostate(2)|skin(1)	28	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CACATCCCCTACCCCCCGGACC	0.644													7	171	---	---	---	---					
CAD	790	broad.mit.edu	37	2	27456981	27456982	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr2:27456981_27456982insC	ENST00000264705.4	+	22	3667_3668	c.3505_3506insC	c.(3505-3507)cccfs	p.P1169fs	CAD_ENST00000403525.1_Frame_Shift_Ins_p.P1106fs	NM_004341.3	NP_004332.2	P27708	PYR1_HUMAN	carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase	1169	ATP-grasp 2.|CPSase (Carbamoyl-phosphate synthase).|CPSase B.				'de novo' pyrimidine base biosynthetic process|drug metabolic process|glutamine metabolic process|peptidyl-threonine phosphorylation|protein autophosphorylation|pyrimidine nucleoside biosynthetic process|pyrimidine nucleotide biosynthetic process	cytosol|neuronal cell body|nuclear matrix|terminal button	aspartate binding|aspartate carbamoyltransferase activity|ATP binding|carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity|dihydroorotase activity|enzyme binding|identical protein binding|metal ion binding|protein kinase activity			NS(1)|breast(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(19)|lung(40)|ovary(6)|pancreas(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	92	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				L-Aspartic Acid(DB00128)|L-Glutamine(DB00130)	GACGCTGGTGACCCCCCCACAA	0.574													7	73	---	---	---	---					
ANTXR1	84168	broad.mit.edu	37	2	69409763	69409764	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr2:69409763_69409764insC	ENST00000303714.4	+	16	1646_1647	c.1324_1325insC	c.(1324-1326)cccfs	p.P442fs		NM_032208.2	NP_115584.1	Q9H6X2	ANTR1_HUMAN	anthrax toxin receptor 1	442					actin cytoskeleton reorganization|substrate adhesion-dependent cell spreading	filopodium membrane|integral to membrane|lamellipodium membrane	actin filament binding|collagen binding|metal ion binding|protein binding|transmembrane receptor activity			haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(16)|ovary(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	29						TCGGCCTTCTTCCCCCCGGAAG	0.421									Familial Infantile Hemangioma				7	367	---	---	---	---					
ANKRD36BP2	645784	broad.mit.edu	37	2	89082293	89082294	+	RNA	INS	-	-	ATTT			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr2:89082293_89082294insATTT	ENST00000393525.3	+	0	503																											ATTAAAGTCTCATATGTTGAAC	0.332													7	39	---	---	---	---					
XIRP2	129446	broad.mit.edu	37	2	168099957	168099958	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr2:168099957_168099958insG	ENST00000409195.1	+	9	2144_2145	c.2055_2056insG	c.(2053-2058)acggggfs	p.TG685fs	XIRP2_ENST00000409728.1_Intron|XIRP2_ENST00000295237.9_Frame_Shift_Ins_p.TG685fs|XIRP2_ENST00000409043.1_Intron|XIRP2_ENST00000409605.1_Intron|XIRP2_ENST00000409756.2_Intron|XIRP2_ENST00000420519.1_Intron|XIRP2_ENST00000409273.1_Frame_Shift_Ins_p.TG463fs	NM_152381.5	NP_689594.4	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2	510					actin cytoskeleton organization	cell junction	actin binding			NS(3)|biliary_tract(2)|breast(5)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(51)|lung(160)|ovary(7)|pancreas(3)|prostate(11)|skin(14)|stomach(5)|upper_aerodigestive_tract(8)|urinary_tract(7)	315						AGGACATAACTGGGGGGGATGT	0.421													8	166	---	---	---	---					
NEUROD1	4760	broad.mit.edu	37	2	182542971	182542972	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr2:182542971_182542972insG	ENST00000295108.3	-	2	1073_1074	c.616_617insC	c.(616-618)cctfs	p.P206fs	CERKL_ENST00000479558.1_Intron|NEUROD1_ENST00000496876.1_Intron	NM_002500.4	NP_002491.2	Q13562	NDF1_HUMAN	neuronal differentiation 1	206					amacrine cell differentiation|cerebellum development|dentate gyrus development|embryonic organ morphogenesis|enteroendocrine cell differentiation|glucose homeostasis|inner ear development|insulin secretion|negative regulation of apoptosis|nitric oxide mediated signal transduction|positive regulation of apoptosis|positive regulation of neuron differentiation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of cell cycle arrest|regulation of intestinal epithelial structure maintenance|response to glucose stimulus	cytoplasm|nucleus	chromatin binding|E-box binding|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription factor binding			endometrium(3)|kidney(1)|large_intestine(6)|lung(9)|ovary(3)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	25			OV - Ovarian serous cystadenocarcinoma(117;0.088)			CGTCGGCAGGTGGGGGGGCATG	0.619													9	192	---	---	---	---					
ITGAV	3685	broad.mit.edu	37	2	187521084	187521085	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr2:187521084_187521085insG	ENST00000261023.3	+	17	1949_1950	c.1675_1676insG	c.(1675-1677)gggfs	p.G559fs	ITGAV_ENST00000374907.3_Frame_Shift_Ins_p.G523fs|ITGAV_ENST00000433736.2_Frame_Shift_Ins_p.G513fs|AC017101.10_ENST00000453665.1_RNA	NM_002210.3	NP_002201.1	P06756	ITAV_HUMAN	integrin, alpha V	559					angiogenesis|axon guidance|blood coagulation|cell-matrix adhesion|entry of bacterium into host cell|entry of symbiont into host cell by promotion of host phagocytosis|entry of virus into host cell|ERK1 and ERK2 cascade|integrin-mediated signaling pathway|leukocyte migration|negative regulation of apoptosis|negative regulation of lipid storage|negative regulation of lipid transport|negative regulation of lipoprotein metabolic process|negative regulation of low-density lipoprotein particle receptor biosynthetic process|negative regulation of macrophage derived foam cell differentiation|positive regulation of cell adhesion|positive regulation of cell proliferation|regulation of apoptotic cell clearance	integrin complex	receptor activity|transforming growth factor beta binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(6)|lung(19)|ovary(2)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	47			OV - Ovarian serous cystadenocarcinoma(117;0.0185)|Epithelial(96;0.072)|all cancers(119;0.189)	STAD - Stomach adenocarcinoma(3;0.106)|COAD - Colon adenocarcinoma(31;0.108)		GACTATTTCAAGGGGGGGACTG	0.431													15	321	---	---	---	---					
INPP5D	3635	broad.mit.edu	37	2	234072358	234072359	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr2:234072358_234072359insC	ENST00000359570.5	+	14	1210_1211	c.1210_1211insC	c.(1210-1212)cccfs	p.P404fs	INPP5D_ENST00000538935.1_Frame_Shift_Ins_p.P403fs|INPP5D_ENST00000455936.2_Frame_Shift_Ins_p.P168fs|INPP5D_ENST00000450745.1_Frame_Shift_Ins_p.P168fs			Q92835	SHIP1_HUMAN	inositol polyphosphate-5-phosphatase, 145kDa	416					apoptosis|blood coagulation|leukocyte migration|T cell receptor signaling pathway	cytosol	inositol-polyphosphate 5-phosphatase activity|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|SH3 domain binding			central_nervous_system(1)|ovary(1)	2		Breast(86;0.0013)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0273)|Acute lymphoblastic leukemia(138;0.0328)|Lung NSC(271;0.0843)		Epithelial(121;1.16e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000479)|LUSC - Lung squamous cell carcinoma(224;0.00655)|Lung(119;0.00802)|GBM - Glioblastoma multiforme(43;0.0185)		TGAAGGTAACGCCCCCCCTCCC	0.535													11	261	---	---	---	---					
FANCD2	2177	broad.mit.edu	37	3	10088407	10088410	+	Splice_Site	DEL	AGTA	AGTA	-	rs146316187		TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr3:10088407_10088410delAGTA	ENST00000287647.3	+	15	1371	c.1278_splice	c.e15+1	p.426_splice	FANCD2_ENST00000419585.1_Splice_Site_p.426_splice|FANCD2_ENST00000383807.1_Splice_Site_p.426_splice|FANCD2_ENST00000383806.1_Splice_Site_p.426_splice	NM_033084.3	NP_149075.2	Q9BXW9	FACD2_HUMAN	Fanconi anemia, complementation group D2	426					DNA repair|response to gamma radiation	nucleoplasm	protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(10)|ovary(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(3)	51				OV - Ovarian serous cystadenocarcinoma(96;0.148)		TTCATTACTTAGTAAGTGTCAGAG	0.358			"""D, Mis, N, F"""			"""AML, leukemia"""		Involved in tolerance or repair of DNA crosslinks	Fanconi Anemia				18	44	---	---	---	---					
RPL32	6161	broad.mit.edu	37	3	12880929	12880930	+	Frame_Shift_Ins	INS	-	-	T			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr3:12880929_12880930insT	ENST00000429711.2	-	3	295_296	c.196_197insA	c.(196-198)aaafs	p.K66fs	RPL32_ENST00000396957.1_Frame_Shift_Ins_p.K66fs|RPL32_ENST00000435983.1_Frame_Shift_Ins_p.K66fs|RPL32_ENST00000273223.6_Frame_Shift_Ins_p.K84fs|RPL32_ENST00000396953.2_Frame_Shift_Ins_p.K66fs	NM_000994.3	NP_000985.1	P62910	RL32_HUMAN	ribosomal protein L32	66					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosol|ribosome	protein binding|structural constituent of ribosome			kidney(1)|large_intestine(2)|lung(2)|ovary(1)	6						CATGTGCTTTGTTTTTTTGTTG	0.515													9	385	---	---	---	---					
KCTD6	200845	broad.mit.edu	37	3	58486771	58486772	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr3:58486771_58486772insG	ENST00000355076.6	+	2	1109_1110	c.126_127insG	c.(124-129)ttggggfs	p.LG42fs	KCTD6_ENST00000404589.3_Frame_Shift_Ins_p.LG42fs|KCTD6_ENST00000479470.1_3'UTR|KCTD6_ENST00000490264.1_Frame_Shift_Ins_p.LG42fs	NM_153331.3	NP_699162.3	Q8NC69	KCTD6_HUMAN	potassium channel tetramerization domain containing 6	42	BTB.					voltage-gated potassium channel complex	voltage-gated potassium channel activity			endometrium(1)|large_intestine(2)|lung(1)|skin(1)	5				BRCA - Breast invasive adenocarcinoma(55;0.000177)|Kidney(10;0.00229)|KIRC - Kidney renal clear cell carcinoma(10;0.00258)|OV - Ovarian serous cystadenocarcinoma(275;0.148)		GAGCTATGTTTGGGGGGGACTT	0.465													8	254	---	---	---	---					
GRK7	131890	broad.mit.edu	37	3	141535707	141535708	+	Frame_Shift_Ins	INS	-	-	G	rs149574289		TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr3:141535707_141535708insG	ENST00000264952.2	+	4	1614_1615	c.1477_1478insG	c.(1477-1479)gggfs	p.G493fs		NM_139209.2	NP_631948.1	Q8WTQ7	GRK7_HUMAN	G protein-coupled receptor kinase 7	493	AGC-kinase C-terminal.				visual perception	membrane	ATP binding|G-protein coupled receptor kinase activity|signal transducer activity	p.R493L(1)		endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(3)|lung(14)|ovary(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	26						CTCTGAGGTTCGGGGGGTGGAA	0.460													15	628	---	---	---	---					
SAMD7	344658	broad.mit.edu	37	3	169646267	169646268	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr3:169646267_169646268insG	ENST00000428432.2	+	7	1331_1332	c.942_943insG	c.(940-945)atggggfs	p.MG314fs	SAMD7_ENST00000335556.3_Frame_Shift_Ins_p.MG314fs	NM_182610.2	NP_872416.1	Q7Z3H4	SAMD7_HUMAN	sterile alpha motif domain containing 7	314										NS(1)|biliary_tract(1)|breast(1)|kidney(1)|large_intestine(4)|lung(15)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	31	all_cancers(22;1.55e-22)|all_epithelial(15;2.41e-27)|all_lung(20;3.52e-17)|Lung NSC(18;1.44e-16)|Ovarian(172;0.000337)|Breast(254;0.169)		Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.0106)			TGGTTACAATTGGGGGGAATCT	0.381													7	300	---	---	---	---					
ABCC5	10057	broad.mit.edu	37	3	183700629	183700630	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr3:183700629_183700630insC	ENST00000334444.6	-	6	997_998	c.757_758insG	c.(757-759)catfs	p.H253fs	ABCC5_ENST00000265586.6_Frame_Shift_Ins_p.H253fs|ABCC5_ENST00000492216.1_5'UTR	NM_005688.2	NP_005679.2	O15440	MRP5_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 5	253	ABC transmembrane type-1 1.					integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of substances|organic anion transmembrane transporter activity			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(9)|lung(32)|ovary(3)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	62	all_cancers(143;1.85e-10)|Ovarian(172;0.0303)		Epithelial(37;1.74e-35)|OV - Ovarian serous cystadenocarcinoma(80;6.48e-22)			GGTTAGGATGGCCCCCCGCAAG	0.515													7	184	---	---	---	---					
SLC51A	200931	broad.mit.edu	37	3	195955037	195955038	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr3:195955037_195955038insG	ENST00000296327.5	+	5	623_624	c.414_415insG	c.(412-417)ttggggfs	p.LG138fs		NM_152672.5	NP_689885.4			solute carrier family 51, alpha subunit																		TGGAAGGCTTTGGGGGGAAGGA	0.614													7	602	---	---	---	---					
EVC	2121	broad.mit.edu	37	4	5785361	5785362	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr4:5785361_5785362insC	ENST00000382674.2	+	12	1830_1831	c.1646_1647insC	c.(1645-1647)cccfs	p.P549fs	EVC_ENST00000264956.6_Frame_Shift_Ins_p.P549fs			P57679	EVC_HUMAN	Ellis van Creveld syndrome	549					muscle organ development	integral to membrane				NS(1)|breast(1)|endometrium(2)|large_intestine(10)|lung(11)|ovary(1)|skin(1)|stomach(1)	28		Myeloproliferative disorder(84;0.117)				ATGACTGGCCTCCCCCCGGAAG	0.584													7	363	---	---	---	---					
ANK2	287	broad.mit.edu	37	4	114280134	114280135	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr4:114280134_114280135insG	ENST00000357077.4	+	38	10413_10414	c.10360_10361insG	c.(10360-10362)gggfs	p.G3454fs	ANK2_ENST00000506722.1_Intron|ANK2_ENST00000394537.3_Intron|ANK2_ENST00000509550.1_Intron|ANK2_ENST00000510275.2_Intron|ANK2_ENST00000264366.6_Frame_Shift_Ins_p.G3421fs	NM_001148.4	NP_001139.3	Q01484	ANK2_HUMAN	ankyrin 2, neuronal	3421					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding	p.T3457fs*8(1)		NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(10)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(54)|liver(2)|lung(112)|ovary(8)|pancreas(1)|prostate(7)|skin(11)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(10)	248		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		ATCTTCCTGCAGGGGGGGCACG	0.455													10	111	---	---	---	---					
TLR3	7098	broad.mit.edu	37	4	186997804	186997805	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr4:186997804_186997805insG	ENST00000296795.2	+	2	135_136	c.31_32insG	c.(31-33)gggfs	p.G11fs		NM_003265.2	NP_003256.1	O15455	TLR3_HUMAN	toll-like receptor 3	11					activation of NF-kappaB-inducing kinase activity|cellular response to mechanical stimulus|defense response to bacterium|defense response to virus|detection of virus|hyperosmotic response|I-kappaB phosphorylation|inflammatory response|innate immune response|MyD88-independent toll-like receptor signaling pathway|negative regulation of osteoclast differentiation|positive regulation of chemokine production|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of interferon-beta production|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of toll-like receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|toll-like receptor 3 signaling pathway	endoplasmic reticulum membrane|endosome membrane|integral to plasma membrane	double-stranded RNA binding|transmembrane receptor activity			breast(1)|endometrium(5)|large_intestine(8)|lung(8)|ovary(2)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	29		all_cancers(14;4.27e-52)|all_epithelial(14;7.69e-39)|all_lung(41;1.34e-13)|Lung NSC(41;3.58e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.0066)|Hepatocellular(41;0.00886)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|all_neural(102;0.243)		OV - Ovarian serous cystadenocarcinoma(60;1.47e-11)|BRCA - Breast invasive adenocarcinoma(30;1.14e-05)|GBM - Glioblastoma multiforme(59;0.000107)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.16)		TATCTACTTTTGGGGGGGCCTT	0.446													8	173	---	---	---	---					
FAT1	2195	broad.mit.edu	37	4	187558038	187558039	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr4:187558038_187558039insG	ENST00000441802.2	-	5	3881_3882	c.3672_3673insC	c.(3670-3675)ccaatcfs	p.I1225fs		NM_005245.3	NP_005236.2	Q14517	FAT1_HUMAN	FAT atypical cadherin 1	1225	Cadherin 10.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(38)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(33)|lung(88)|ovary(13)|pancreas(2)|prostate(16)|skin(2)|upper_aerodigestive_tract(11)|urinary_tract(4)	228						ATGGTTGATTTGGGGGGACTAC	0.361										HNSCC(5;0.00058)			7	604	---	---	---	---					
PDZD2	23037	broad.mit.edu	37	5	31799540	31799541	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr5:31799540_31799541insC	ENST00000438447.1	+	2	573_574	c.185_186insC	c.(184-186)accfs	p.T62fs	PDZD2_ENST00000282493.3_Frame_Shift_Ins_p.T62fs			O15018	PDZD2_HUMAN	PDZ domain containing 2	62					cell adhesion	cell-cell junction|endoplasmic reticulum|extracellular region|nucleus		p.E65fs*34(1)|p.E65fs*21(1)		NS(2)|breast(4)|central_nervous_system(5)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(31)|lung(58)|ovary(6)|prostate(2)|skin(8)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	148						CCTGATCACAGCCCCCCCGAAA	0.589													7	154	---	---	---	---					
SLC1A3	6507	broad.mit.edu	37	5	36679798	36679799	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr5:36679798_36679799insG	ENST00000265113.4	+	7	1406_1407	c.930_931insG	c.(928-933)atggggfs	p.MG310fs	CTD-2353F22.1_ENST00000510740.1_RNA|SLC1A3_ENST00000381918.3_Frame_Shift_Ins_p.MG310fs	NM_004172.4	NP_004163.3	P43003	EAA1_HUMAN	solute carrier family 1 (glial high affinity glutamate transporter), member 3	310					D-aspartate import|L-glutamate import|neurotransmitter uptake	integral to membrane|membrane fraction	high-affinity glutamate transmembrane transporter activity|sodium:dicarboxylate symporter activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(8)|liver(1)|lung(23)|skin(1)	41	all_lung(31;0.000245)		Epithelial(62;0.0444)|Lung(74;0.111)|all cancers(62;0.128)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)		L-Glutamic Acid(DB00142)	TGGGTGTGATTGGGGGGCAGCT	0.520													7	477	---	---	---	---					
C6	729	broad.mit.edu	37	5	41181559	41181560	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr5:41181559_41181560insC	ENST00000263413.3	-	7	1092_1093	c.828_829insG	c.(826-831)gggctcfs	p.L277fs	C6_ENST00000475349.1_5'UTR|C6_ENST00000337836.5_Frame_Shift_Ins_p.L277fs	NM_001115131.1	NP_001108603.2	P13671	CO6_HUMAN	complement component 6	277	MACPF.				complement activation, classical pathway|cytolysis|innate immune response	membrane attack complex	protein binding			central_nervous_system(2)|cervix(2)|endometrium(2)|kidney(7)|large_intestine(16)|liver(1)|lung(51)|ovary(3)|prostate(1)|skin(9)|upper_aerodigestive_tract(2)	96		Breast(839;1.07e-05)|Ovarian(839;0.0228)|Lung SC(612;0.0548)|Lung NSC(810;0.128)|all_neural(839;0.157)				CTGAAAGAGCTCCCCCCCTGAC	0.376													10	156	---	---	---	---					
ARAP3	64411	broad.mit.edu	37	5	141049341	141049342	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr5:141049341_141049342insC	ENST00000239440.4	-	16	2351_2352	c.2286_2287insG	c.(2284-2289)ggggatfs	p.D763fs	ARAP3_ENST00000513878.1_Frame_Shift_Ins_p.D425fs|ARAP3_ENST00000508305.1_Frame_Shift_Ins_p.D665fs	NM_022481.5	NP_071926.4	Q8WWN8	ARAP3_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3	763					cytoskeleton organization|negative regulation of cell migration|negative regulation of Rho protein signal transduction|regulation of ARF GTPase activity|regulation of cell shape|small GTPase mediated signal transduction|vesicle-mediated transport	cytoskeleton|cytosol|lamellipodium|plasma membrane|ruffle	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|Rho GTPase activator activity|zinc ion binding			NS(1)|breast(7)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|lung(14)|ovary(1)|prostate(2)|skin(4)|stomach(1)	53						TGCTGGATCCTCCCCCCAGCGA	0.579													8	492	---	---	---	---					
PCDH12	51294	broad.mit.edu	37	5	141336747	141336748	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr5:141336747_141336748insG	ENST00000231484.3	-	1	1879_1880	c.669_670insC	c.(667-672)ccagtcfs	p.V224fs		NM_016580.2	NP_057664.1	Q9NPG4	PCD12_HUMAN	protocadherin 12	224	Cadherin 2.				neuron recognition	integral to plasma membrane	calcium ion binding			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|lung(14)|ovary(3)|prostate(2)|skin(1)	38		all_hematologic(541;0.0999)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GTACCTGACTTGGGGGGGTTCC	0.480													9	243	---	---	---	---					
TCOF1	6949	broad.mit.edu	37	5	149755744	149755745	+	Frame_Shift_Ins	INS	-	-	C	rs2071240	byFrequency	TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr5:149755744_149755745insC	ENST00000451292.1	+	13	2101_2102	c.1993_1994insC	c.(1993-1995)cccfs	p.P665fs	TCOF1_ENST00000394269.3_Frame_Shift_Ins_p.P665fs|TCOF1_ENST00000377797.3_Frame_Shift_Ins_p.P665fs|TCOF1_ENST00000445265.2_Frame_Shift_Ins_p.P588fs|TCOF1_ENST00000323668.7_Frame_Shift_Ins_p.P588fs|TCOF1_ENST00000439160.2_Frame_Shift_Ins_p.P665fs|TCOF1_ENST00000504761.2_Frame_Shift_Ins_p.P665fs|TCOF1_ENST00000513346.1_Frame_Shift_Ins_p.P665fs			Q13428	TCOF_HUMAN	Treacher Collins-Franceschetti syndrome 1	665			A -> P (in dbSNP:rs2071240).		skeletal system development	nucleolus	protein binding|transporter activity			NS(1)|breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(8)|ovary(2)|pancreas(1)|prostate(2)|skin(1)	35		all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			GGGCACCCAAGCCCCCCGGAAA	0.584													7	288	---	---	---	---					
GCNT2	2651	broad.mit.edu	37	6	10557409	10557410	+	Frame_Shift_Ins	INS	-	-	C	rs55808116		TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr6:10557409_10557410insC	ENST00000316170.3	+	1	1170_1171	c.753_754insC	c.(751-756)ccccccfs	p.PP251fs	GCNT2_ENST00000379597.3_Intron|GCNT2_ENST00000397423.2_Intron|GCNT2_ENST00000495262.1_Intron|GCNT2_ENST00000410107.1_Intron	NM_001491.2	NP_001482.1	Q8N0V5	GNT2A_HUMAN	glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)	253						Golgi membrane|integral to membrane	N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity			endometrium(2)|kidney(1)|large_intestine(5)|lung(2)|ovary(2)	12	Ovarian(93;0.107)|Breast(50;0.148)	all_hematologic(90;0.107)		KIRC - Kidney renal clear cell carcinoma(1;0.099)|Kidney(1;0.119)		TGAAACCGCCTCCCCCCCATAA	0.485													18	256	---	---	---	---					
PHACTR1	221692	broad.mit.edu	37	6	13206134	13206135	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr6:13206134_13206135insG	ENST00000379350.1	+	7	881_882	c.752_753insG	c.(751-753)gggfs	p.G251fs	PHACTR1_ENST00000379345.2_Intron|PHACTR1_ENST00000457702.2_Frame_Shift_Ins_p.G106fs|PHACTR1_ENST00000332995.7_Frame_Shift_Ins_p.G251fs			Q9C0D0	PHAR1_HUMAN	phosphatase and actin regulator 1	251						cell junction|cytoplasm|synapse	actin binding|protein phosphatase inhibitor activity			breast(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(10)|ovary(1)|skin(2)|upper_aerodigestive_tract(3)	26	Breast(50;0.0427)|Ovarian(93;0.12)	all_hematologic(90;0.122)|Lung SC(78;0.195)	Epithelial(50;0.146)|BRCA - Breast invasive adenocarcinoma(129;0.239)			TGTATGCCCGTGGGGGGGCCAG	0.599													11	202	---	---	---	---					
DCDC2	51473	broad.mit.edu	37	6	24205282	24205283	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr6:24205282_24205283insC	ENST00000378454.3	-	8	1271_1272	c.970_971insG	c.(970-972)agcfs	p.S324fs	DCDC2_ENST00000378450.3_Frame_Shift_Ins_p.S77fs	NM_001195610.1|NM_016356.3	NP_001182539.1|NP_057440.2	Q9UHG0	DCDC2_HUMAN	doublecortin domain containing 2	324					cellular defense response|intracellular signal transduction|neuron migration					breast(1)|endometrium(2)|kidney(3)|large_intestine(8)|lung(12)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	32		Ovarian(999;0.101)				GACTTCTGCTGCCCCCCGTGTT	0.411													36	1090	---	---	---	---					
NOTCH4	4855	broad.mit.edu	37	6	32181941	32181942	+	Frame_Shift_Ins	INS	-	-	C	rs143622513		TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr6:32181941_32181942insC	ENST00000375023.3	-	13	2250_2251	c.2112_2113insG	c.(2110-2115)ggcctgfs	p.L705fs	NOTCH4_ENST00000465528.1_5'UTR	NM_004557.3	NP_004548.3	Q99466	NOTC4_HUMAN	notch 4	705	EGF-like 18.				cell fate determination|embryo development|hemopoiesis|mammary gland development|negative regulation of endothelial cell differentiation|Notch receptor processing|Notch signaling pathway|patterning of blood vessels|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|protein heterodimerization activity|receptor activity			NS(1)|autonomic_ganglia(1)|breast(4)|central_nervous_system(4)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(47)|ovary(5)|prostate(4)|skin(10)|upper_aerodigestive_tract(1)|urinary_tract(1)	100						GGGTAGCAGGTCCCCCCATGGG	0.604													8	462	---	---	---	---					
FANCE	2178	broad.mit.edu	37	6	35425714	35425715	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr6:35425714_35425715insC	ENST00000229769.2	+	4	1107_1108	c.922_923insC	c.(922-924)cccfs	p.P308fs		NM_021922.2	NP_068741.1	Q9HB96	FANCE_HUMAN	Fanconi anemia, complementation group E	308	Interaction with FANCC.				DNA repair	nucleoplasm	protein binding			NS(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(3)|ovary(1)|skin(2)	13						ATTGGAGGATGCCCCCCCAGTT	0.540			"""N, F, S"""			"""AML, leukemia"""		Involved in tolerance or repair of DNA crosslinks	Fanconi Anemia				9	113	---	---	---	---					
BRPF3	27154	broad.mit.edu	37	6	36181728	36181729	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr6:36181728_36181729insC	ENST00000357641.6	+	8	2807_2808	c.2554_2555insC	c.(2554-2556)cccfs	p.P852fs	BRPF3_ENST00000534400.1_Frame_Shift_Ins_p.P852fs|BRPF3_ENST00000339717.7_Intron|BRPF3_ENST00000543502.1_Intron|BRPF3_ENST00000443324.2_Intron|BRPF3_ENST00000534694.1_Intron	NM_015695.2	NP_056510.2	Q9ULD4	BRPF3_HUMAN	bromodomain and PHD finger containing, 3	852					histone H3 acetylation|platelet activation|platelet degranulation	cytosol|extracellular region|MOZ/MORF histone acetyltransferase complex	protein binding|zinc ion binding			breast(1)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(8)|lung(15)|ovary(1)|prostate(1)|skin(4)|urinary_tract(2)	40						TGAGCAAGAATCCCCCCCGGAG	0.500													8	81	---	---	---	---					
REV3L	5980	broad.mit.edu	37	6	111693903	111693904	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr6:111693903_111693904insG	ENST00000435970.1	-	15	6236_6237	c.5420_5421insC	c.(5419-5421)cagfs	p.Q1807fs	REV3L_ENST00000358835.3_Frame_Shift_Ins_p.Q1885fs|REV3L_ENST00000368802.3_Frame_Shift_Ins_p.Q1885fs|REV3L_ENST00000368805.1_Frame_Shift_Ins_p.Q1885fs			O60673	DPOLZ_HUMAN	REV3-like, polymerase (DNA directed), zeta, catalytic subunit	1885					DNA-dependent DNA replication|translesion synthesis	nucleus|zeta DNA polymerase complex	DNA binding|DNA-directed DNA polymerase activity|metal ion binding|nucleotide binding			NS(2)|breast(1)|endometrium(6)|kidney(7)|large_intestine(30)|lung(25)|ovary(3)|prostate(5)|skin(8)|upper_aerodigestive_tract(1)	88		all_cancers(87;7.57e-06)|Acute lymphoblastic leukemia(125;2.46e-08)|all_hematologic(75;1.08e-06)|all_epithelial(87;0.00138)|Colorectal(196;0.021)		OV - Ovarian serous cystadenocarcinoma(136;0.0314)|Epithelial(106;0.057)|all cancers(137;0.0663)		CTTCCCTACTTGGGGGGGACAT	0.431								DNA polymerases (catalytic subunits)					18	323	---	---	---	---					
TAB2	23118	broad.mit.edu	37	6	149700166	149700167	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr6:149700166_149700167insC	ENST00000367456.1	+	4	1692_1693	c.1115_1116insC	c.(1114-1116)accfs	p.T372fs	TAB2_ENST00000392282.1_Frame_Shift_Ins_p.T372fs|TAB2_ENST00000536230.1_Frame_Shift_Ins_p.T340fs|TAB2_ENST00000538427.1_Frame_Shift_Ins_p.T372fs|TAB2_ENST00000286332.5_Frame_Shift_Ins_p.T372fs			Q9NYJ8	TAB2_HUMAN	TGF-beta activated kinase 1/MAP3K7 binding protein 2	372					activation of MAPK activity|heart development|I-kappaB kinase/NF-kappaB cascade|innate immune response|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|stress-activated MAPK cascade|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|endosome membrane|plasma membrane	K63-linked polyubiquitin binding|zinc ion binding	p.S372S(1)		breast(2)|endometrium(6)|kidney(3)|large_intestine(2)|lung(7)|ovary(1)|urinary_tract(1)	22						ATAGCTGCCAGCCCCCCAAATA	0.495													7	131	---	---	---	---					
GRM3	2913	broad.mit.edu	37	7	86415681	86415682	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr7:86415681_86415682insC	ENST00000361669.2	+	3	1672_1673	c.573_574insC	c.(571-576)gtccccfs	p.VP191fs	AC005009.2_ENST00000452471.1_RNA|GRM3_ENST00000394720.2_Frame_Shift_Ins_p.VP189fs|GRM3_ENST00000536043.1_Frame_Shift_Ins_p.VP63fs|GRM3_ENST00000546348.1_Intron|GRM3_ENST00000439827.1_Frame_Shift_Ins_p.VP191fs|AC005009.2_ENST00000418031.1_RNA	NM_000840.2	NP_000831.2	Q14832	GRM3_HUMAN	glutamate receptor, metabotropic 3	191					synaptic transmission	integral to plasma membrane				NS(2)|breast(6)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(43)|ovary(3)|pancreas(2)|prostate(4)|skin(25)|upper_aerodigestive_tract(5)	109	Esophageal squamous(14;0.0058)|all_lung(186;0.132)|Lung NSC(181;0.142)				Acamprosate(DB00659)|Nicotine(DB00184)	CCAGGACCGTGCCCCCCGACTT	0.564													8	198	---	---	---	---					
KEL	3792	broad.mit.edu	37	7	142639979	142639980	+	Frame_Shift_Ins	INS	-	-	C	rs140258059		TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr7:142639979_142639980insC	ENST00000355265.2	-	17	2397_2398	c.1923_1924insG	c.(1921-1926)ggtagcfs	p.S642fs		NM_000420.2	NP_000411.1	P23276	KELL_HUMAN	Kell blood group, metallo-endopeptidase	642					proteolysis|vasoconstriction	integral to membrane|plasma membrane	metal ion binding|metalloendopeptidase activity|protein binding			central_nervous_system(1)|endometrium(3)|kidney(5)|large_intestine(11)|lung(34)|ovary(3)|prostate(2)|skin(1)	60	Melanoma(164;0.059)					GCGATGGCTAGCCCCCCAACGT	0.500													8	646	---	---	---	---					
ABCA1	19	broad.mit.edu	37	9	107593322	107593323	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr9:107593322_107593323insC	ENST00000374736.3	-	14	2169_2170	c.1775_1776insG	c.(1774-1776)gttfs	p.V592fs		NM_005502.3	NP_005493.2	O95477	ABCA1_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 1	592					Cdc42 protein signal transduction|cellular lipid metabolic process|cholesterol efflux|cholesterol homeostasis|cholesterol metabolic process|endosome transport|G-protein coupled receptor protein signaling pathway|high-density lipoprotein particle assembly|interleukin-1 beta secretion|intracellular cholesterol transport|lysosome organization|negative regulation of cholesterol storage|negative regulation of macrophage derived foam cell differentiation|phospholipid efflux|phospholipid homeostasis|platelet dense granule organization|positive regulation of cAMP biosynthetic process|reverse cholesterol transport	integral to plasma membrane|membrane fraction|membrane raft|phagocytic vesicle	anion transmembrane transporter activity|apolipoprotein A-I receptor activity|ATP binding|ATPase activity|cholesterol transporter activity|phospholipid transporter activity|small GTPase binding|syntaxin-13 binding			NS(1)|autonomic_ganglia(1)|breast(5)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(31)|liver(1)|lung(40)|ovary(5)|pancreas(2)|prostate(4)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	115				OV - Ovarian serous cystadenocarcinoma(323;0.023)	Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	AGTAGGCGAAGCCCCCCCAGAC	0.540													11	177	---	---	---	---					
ZNF462	58499	broad.mit.edu	37	9	109691601	109691602	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr9:109691601_109691602insG	ENST00000277225.5	+	3	5697_5698	c.5408_5409insG	c.(5407-5409)tggfs	p.W1803fs	ZNF462_ENST00000441147.2_Frame_Shift_Ins_p.W648fs|ZNF462_ENST00000457913.1_Frame_Shift_Ins_p.W1803fs			Q96JM2	ZN462_HUMAN	zinc finger protein 462	1803					transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(2)|autonomic_ganglia(2)|breast(5)|central_nervous_system(4)|cervix(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(17)|large_intestine(20)|lung(32)|ovary(5)|prostate(6)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	119						GCCAGCAAGTTGGGGGGCTACT	0.550													9	199	---	---	---	---					
BTRC	8945	broad.mit.edu	37	10	103310572	103310573	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr10:103310572_103310573insC	ENST00000370187.3	+	14	1891_1892	c.1773_1774insC	c.(1771-1776)gaccccfs	p.DP591fs	BTRC_ENST00000393441.4_Frame_Shift_Ins_p.DP550fs|BTRC_ENST00000408038.2_Frame_Shift_Ins_p.DP555fs|BTRC_ENST00000493877.1_3'UTR	NM_033637.3	NP_378663.1	Q9Y297	FBW1A_HUMAN	beta-transducin repeat containing E3 ubiquitin protein ligase	591					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|positive regulation of proteolysis|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein destabilization|viral reproduction|Wnt receptor signaling pathway	cytosol|nucleus|SCF ubiquitin ligase complex				endometrium(4)|kidney(2)|large_intestine(6)|lung(11)|ovary(2)|stomach(1)|urinary_tract(1)	27		Colorectal(252;0.234)		Epithelial(162;1.05e-08)|all cancers(201;6.59e-07)		CCCAAGCTGAACCCCCCCGTTC	0.431													7	131	---	---	---	---					
OR51E1	143503	broad.mit.edu	37	11	4674216	4674217	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr11:4674216_4674217insG	ENST00000396952.5	+	2	1110_1111	c.460_461insG	c.(460-462)gggfs	p.G154fs	OR51E1_ENST00000530215.1_Intron	NM_152430.3	NP_689643.2	Q8TCB6	O51E1_HUMAN	olfactory receptor, family 51, subfamily E, member 1	153					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.A155fs*3(1)		NS(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(13)|ovary(1)|pancreas(1)|skin(1)|stomach(2)	30		Medulloblastoma(188;0.0025)|Breast(177;0.0101)|all_neural(188;0.0227)		Epithelial(150;7.37e-14)|GBM - Glioblastoma multiforme(2;2.85e-05)|BRCA - Breast invasive adenocarcinoma(625;0.00222)|LUSC - Lung squamous cell carcinoma(625;0.19)		TGCTGTGGTGCGGGGGGCTGCA	0.559													9	416	---	---	---	---					
DCHS1	8642	broad.mit.edu	37	11	6662141	6662142	+	Frame_Shift_Ins	INS	-	-	G	rs143767864	byFrequency	TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr11:6662141_6662142insG	ENST00000299441.3	-	2	1114_1115	c.703_704insC	c.(703-705)gagfs	p.E235fs		NM_003737.2	NP_003728.1	Q96JQ0	PCD16_HUMAN	dachsous cadherin-related 1	235	Cadherin 2.				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding	p.R235Q(1)		breast(3)|central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(4)|kidney(4)|large_intestine(16)|liver(1)|lung(41)|ovary(4)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(6)|urinary_tract(4)	103		Medulloblastoma(188;0.00263)|all_neural(188;0.026)		Epithelial(150;6.35e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CTGGGCCCTCCGGGGGGGTGAA	0.589													13	120	---	---	---	---					
DENND5A	23258	broad.mit.edu	37	11	9167316	9167317	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr11:9167316_9167317insC	ENST00000328194.3	-	17	3223_3224	c.2903_2904insG	c.(2902-2904)gtcfs	p.V968fs	DENND5A_ENST00000530044.1_Frame_Shift_Ins_p.V968fs|DENND5A_ENST00000527700.1_Frame_Shift_Ins_p.V311fs	NM_001243254.1|NM_015213.3	NP_001230183.1|NP_056028.2	Q6IQ26	DEN5A_HUMAN	DENN/MADD domain containing 5A	968	PLAT.									breast(1)|endometrium(7)|kidney(2)|large_intestine(8)|liver(1)|lung(16)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	39						TGAACATGGAGCCCCCCAGCTT	0.480													7	445	---	---	---	---					
PAMR1	25891	broad.mit.edu	37	11	35513669	35513670	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr11:35513669_35513670insC	ENST00000378880.2	-	3	747_748	c.302_303insG	c.(301-303)gacfs	p.D101fs	PAMR1_ENST00000532848.1_Frame_Shift_Ins_p.D61fs|PAMR1_ENST00000378878.3_Frame_Shift_Ins_p.D101fs|PAMR1_ENST00000534803.1_5'UTR|PAMR1_ENST00000278360.3_Frame_Shift_Ins_p.D101fs	NM_001001991.1	NP_001001991.1	Q6UXH9	PAMR1_HUMAN	peptidase domain containing associated with muscle regeneration 1	101					proteolysis	extracellular region	serine-type endopeptidase activity			breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(8)|ovary(3)|upper_aerodigestive_tract(1)	26						CATCCAAGGTACCCCCCCATGA	0.520													23	539	---	---	---	---					
DDB1	1642	broad.mit.edu	37	11	61094367	61094368	+	Splice_Site	INS	-	-	G			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr11:61094367_61094368insG	ENST00000301764.7	-	5	947		c.e5-2		DDB1_ENST00000545930.1_Splice_Site|DDB1_ENST00000450997.2_Intron	NM_001923.4	NP_001914.3	Q16531	DDB1_HUMAN	damage-specific DNA binding protein 1, 127kDa						cell cycle checkpoint|interspecies interaction between organisms|nucleotide-excision repair, DNA damage removal|proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	Cul4A-RING ubiquitin ligase complex|Cul4B-RING ubiquitin ligase complex|cytoplasm|nucleoplasm	damaged DNA binding|protein binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(7)|lung(22)|ovary(2)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	48						CTGAGGGTCCTGGGGGGGAAAG	0.515								Nucleotide excision repair (NER)					8	205	---	---	---	---					
CCS	9973	broad.mit.edu	37	11	66366957	66366958	+	Frame_Shift_Ins	INS	-	-	G	rs61731811	byFrequency	TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr11:66366957_66366958insG	ENST00000533244.1	+	4	719_720	c.278_279insG	c.(277-279)cggfs	p.R93fs	CCS_ENST00000310190.4_Frame_Shift_Ins_p.R74fs	NM_005125.1	NP_005116.1	O14618	CCS_HUMAN	copper chaperone for superoxide dismutase	93	Superoxide dismutase-like.				intracellular copper ion transport|oxidation-reduction process|removal of superoxide radicals	cytosol|mitochondrial inner membrane|nucleus|soluble fraction	copper ion transmembrane transporter activity|protein binding|superoxide dismutase copper chaperone activity|zinc ion binding			breast(2)|cervix(1)|large_intestine(2)|lung(3)|stomach(1)	9						GTGGCCATCCTGGGGGGGCCTG	0.644													9	68	---	---	---	---					
OR10G8	219869	broad.mit.edu	37	11	123900396	123900397	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr11:123900396_123900397insC	ENST00000431524.1	+	1	100_101	c.67_68insC	c.(67-69)cccfs	p.P23fs		NM_001004464.1	NP_001004464.1	Q8NGN5	O10G8_HUMAN	olfactory receptor, family 10, subfamily G, member 8	23					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.A23T(1)		breast(1)|endometrium(7)|large_intestine(2)|lung(21)|ovary(1)|prostate(5)|skin(1)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	44		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0521)		AGCGCTGGACGCCCCCCTCTTT	0.589													7	504	---	---	---	---					
ADAMTS8	11095	broad.mit.edu	37	11	130275723	130275724	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr11:130275723_130275724insG	ENST00000257359.6	-	9	3105_3106	c.2399_2400insC	c.(2398-2400)caafs	p.Q800fs		NM_007037.4	NP_008968.4	Q9UP79	ATS8_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 8	800	Spacer.				negative regulation of cell proliferation|proteolysis	proteinaceous extracellular matrix	heparin binding|integrin binding|low affinity phosphate transmembrane transporter activity|metalloendopeptidase activity|zinc ion binding			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(2)|prostate(1)|skin(1)	10	all_hematologic(175;0.0429)	Lung NSC(97;0.000601)|Breast(109;0.000962)|all_lung(97;0.00125)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.039)|Lung(977;0.213)		ATTTGACTTTTGGGGGGAAGAC	0.579													11	895	---	---	---	---					
KDM5A	5927	broad.mit.edu	37	12	442810	442811	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr12:442810_442811insC	ENST00000399788.2	-	12	1857_1858	c.1495_1496insG	c.(1495-1497)gccfs	p.A499fs	KDM5A_ENST00000382815.4_Frame_Shift_Ins_p.A499fs	NM_001042603.1	NP_001036068.1	P29375	KDM5A_HUMAN	lysine (K)-specific demethylase 5A	499	JmjC.				chromatin modification|multicellular organismal development|positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|nucleolus	DNA binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(2)|breast(4)|central_nervous_system(2)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(29)|ovary(1)|prostate(5)|skin(6)|stomach(1)|urinary_tract(2)	77						TGTCTTTGGCTCCCCCCTAGCA	0.465			T	NUP98	AML								8	263	---	---	---	---					
CD4	920	broad.mit.edu	37	12	6924042	6924043	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr12:6924042_6924043insG	ENST00000011653.4	+	5	749_750	c.491_492insG	c.(490-492)cggfs	p.R164fs	CD4_ENST00000541982.1_Frame_Shift_Ins_p.R109fs|CD4_ENST00000538827.1_3'UTR	NM_000616.4|NM_001195015.2|NM_001195016.2|NM_001195017.2	NP_000607.1|NP_001181944.1|NP_001181945.1|NP_001181946.1	P01730	CD4_HUMAN	CD4 molecule	164	Ig-like C2-type 1.				cell adhesion|entry into host cell|immune response|induction by virus of host cell-cell fusion|initiation of viral infection|maintenance of protein location in cell|positive regulation of interleukin-2 biosynthetic process|positive regulation of protein kinase activity|protein palmitoleylation|regulation of defense response to virus by virus|T cell costimulation|T cell receptor signaling pathway|T cell selection|transmembrane receptor protein tyrosine kinase signaling pathway	early endosome|endoplasmic reticulum membrane|integral to membrane|T cell receptor complex	coreceptor activity|extracellular matrix structural constituent|glycoprotein binding|MHC class II protein binding|protein homodimerization activity|protein kinase binding|transmembrane receptor activity|zinc ion binding			breast(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(7)|ovary(1)|prostate(1)	23		Myeloproliferative disorder(1001;0.0122)				AAAAACATACAGGGGGGGAAGA	0.564													9	278	---	---	---	---					
HEBP1	50865	broad.mit.edu	37	12	13142224	13142225	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr12:13142224_13142225insC	ENST00000536942.1	-	2	353_354	c.203_204insG	c.(202-204)gacfs	p.D68fs	HEBP1_ENST00000014930.4_Frame_Shift_Ins_p.D68fs			Q9NRV9	HEBP1_HUMAN	heme binding protein 1	68					circadian rhythm	extracellular region				breast(1)|endometrium(1)|large_intestine(3)|lung(1)|urinary_tract(1)	7		Prostate(47;0.183)		BRCA - Breast invasive adenocarcinoma(232;0.153)		TGTCATTGGTGCCCCCCGCATA	0.554													15	627	---	---	---	---					
KMT2D	8085	broad.mit.edu	37	12	49445525	49445526	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr12:49445525_49445526insG	ENST00000301067.7	-	10	1939_1940	c.1940_1941insC	c.(1939-1941)cccfs	p.P647fs		NM_003482.3	NP_003473.3			lysine (K)-specific methyltransferase 2D																		ATACCTCAGGTGGGGGGGACAT	0.634													11	149	---	---	---	---					
PCBP2	5094	broad.mit.edu	37	12	53856277	53856278	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr12:53856277_53856278insC	ENST00000603815.1	+	8	867_868	c.517_518insC	c.(517-519)cccfs	p.P173fs	PCBP2_ENST00000359462.5_Frame_Shift_Ins_p.P173fs|PCBP2_ENST00000359282.5_Splice_Site_p.P169_splice|PCBP2_ENST00000541275.1_Splice_Site_p.P169_splice|PCBP2_ENST00000437231.1_Splice_Site_p.P169_splice|RP11-793H13.8_ENST00000547717.1_RNA|PCBP2_ENST00000552296.2_Splice_Site_p.P169_splice|PCBP2_ENST00000546463.1_Splice_Site_p.P169_splice|PCBP2_ENST00000552819.1_Frame_Shift_Ins_p.P173fs|PCBP2_ENST00000455667.3_Splice_Site_p.P169_splice|PCBP2_ENST00000447282.1_Frame_Shift_Ins_p.P173fs|PCBP2_ENST00000439930.3_Frame_Shift_Ins_p.P173fs|PCBP2_ENST00000549863.1_Frame_Shift_Ins_p.P173fs|PCBP2_ENST00000548933.1_Frame_Shift_Ins_p.P173fs	NM_001128911.1|NM_001128912.1|NM_005016.5|NM_031989.4	NP_001122383.1|NP_001122384.1|NP_005007.2|NP_114366.1	Q15366	PCBP2_HUMAN	poly(rC) binding protein 2	173					innate immune response|negative regulation of defense response to virus|negative regulation of type I interferon production|nuclear mRNA splicing, via spliceosome|proteasomal ubiquitin-dependent protein catabolic process|response to virus	cytosol|nucleoplasm|ribonucleoprotein complex	DNA binding|RNA binding|ubiquitin protein ligase binding			central_nervous_system(4)|endometrium(2)|kidney(1)|large_intestine(2)|lung(4)|skin(1)|upper_aerodigestive_tract(1)	15						TCTCTCCCAGTCCCCCCCGAAG	0.500													8	128	---	---	---	---					
PDE1B	5153	broad.mit.edu	37	12	54971059	54971060	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr12:54971059_54971060insC	ENST00000243052.3	+	15	1994_1995	c.1558_1559insC	c.(1558-1560)cccfs	p.P520fs	PDE1B_ENST00000550620.1_Frame_Shift_Ins_p.P500fs|PDE1B_ENST00000394277.3_3'UTR|PDE1B_ENST00000538346.1_Frame_Shift_Ins_p.P479fs|PPP1R1A_ENST00000547431.1_3'UTR	NM_000924.3	NP_000915.1	Q01064	PDE1B_HUMAN	phosphodiesterase 1B, calmodulin-dependent	520					activation of phospholipase C activity|apoptosis|nerve growth factor receptor signaling pathway|platelet activation	cytosol|nucleus	3',5'-cyclic-AMP phosphodiesterase activity|calmodulin binding|calmodulin-dependent cyclic-nucleotide phosphodiesterase activity|metal ion binding			endometrium(1)|kidney(3)|large_intestine(4)|lung(16)|ovary(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(4)	31						TGAAGAAGAGGCCCCCCCATCC	0.559													14	349	---	---	---	---					
IKZF4	64375	broad.mit.edu	37	12	56429092	56429093	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr12:56429092_56429093insG	ENST00000262032.5	+	12	2102_2103	c.1735_1736insG	c.(1735-1737)gggfs	p.G579fs	IKZF4_ENST00000431367.2_Frame_Shift_Ins_p.G477fs|IKZF4_ENST00000547791.1_Frame_Shift_Ins_p.G534fs|IKZF4_ENST00000547167.1_Frame_Shift_Ins_p.G579fs|RP11-603J24.4_ENST00000551846.1_RNA			Q9H2S9	IKZF4_HUMAN	IKAROS family zinc finger 4 (Eos)	579					negative regulation of transcription, DNA-dependent	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|endometrium(2)|lung(3)|ovary(1)|prostate(1)	8			UCEC - Uterine corpus endometrioid carcinoma (6;0.025)|OV - Ovarian serous cystadenocarcinoma(18;0.123)			CCACATTGTCCGGGGGGAGCAT	0.554													8	529	---	---	---	---					
PA2G4	5036	broad.mit.edu	37	12	56505301	56505302	+	Frame_Shift_Ins	INS	-	-	A	rs149549286	byFrequency	TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr12:56505301_56505302insA	ENST00000303305.6	+	12	1526_1527	c.1107_1108insA	c.(1105-1110)aaaaaafs	p.KK369fs	PA2G4_ENST00000552766.1_Intron|RP11-603J24.17_ENST00000548595.1_RNA	NM_006191.2	NP_006182.2	Q9UQ80	PA2G4_HUMAN	proliferation-associated 2G4, 38kDa	369	Interaction with RNA (By similarity).|Necessary for nucleolar localization.				cell cycle arrest|cell proliferation|negative regulation of transcription, DNA-dependent|regulation of translation|rRNA processing	cytoplasm|nucleolus|ribonucleoprotein complex	DNA binding|RNA binding|sequence-specific DNA binding transcription factor activity|ubiquitin protein ligase binding			NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(4)|ovary(1)|urinary_tract(1)	12			OV - Ovarian serous cystadenocarcinoma(18;0.0739)			CCCAGAAAAAGAAAAAAAAGAA	0.386													7	177	---	---	---	---					
BAZ2A	11176	broad.mit.edu	37	12	57009177	57009178	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr12:57009177_57009178insC	ENST00000179765.5	-	3	549_550	c.350_351insG	c.(349-351)gcafs	p.A117fs	BAZ2A_ENST00000551812.1_Frame_Shift_Ins_p.A119fs|BAZ2A_ENST00000379441.3_Frame_Shift_Ins_p.A119fs|BAZ2A_ENST00000549884.1_Frame_Shift_Ins_p.A117fs			Q9UIF9	BAZ2A_HUMAN	bromodomain adjacent to zinc finger domain, 2A	119					chromatin silencing at rDNA|DNA methylation|transcription, DNA-dependent	chromatin silencing complex|nucleolus|rDNA heterochromatin	DNA binding|histone acetyl-lysine binding|ligand-dependent nuclear receptor binding|RNA binding|zinc ion binding			breast(1)|cervix(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(15)|urinary_tract(1)	31						GTGGGTATTGTCCCCCCGAGAA	0.584													7	223	---	---	---	---					
NACA	4666	broad.mit.edu	37	12	57114417	57114418	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr12:57114417_57114418insG	ENST00000454682.1	-	3	1177_1178	c.896_897insC	c.(895-897)cgafs	p.R299fs	NACA_ENST00000546392.1_Intron|NACA_ENST00000548563.1_Intron|NACA_ENST00000356769.3_Intron|NACA_ENST00000552540.1_Intron|NACA_ENST00000393891.4_Intron|NACA_ENST00000551793.1_Intron|NACA_ENST00000550952.1_Frame_Shift_Ins_p.R299fs	NM_001113203.2	NP_001106674.2	Q13765	NACA_HUMAN	nascent polypeptide-associated complex alpha subunit	0					interspecies interaction between organisms|protein transport|transcription, DNA-dependent|translation	nascent polypeptide-associated complex|nucleus	DNA binding			breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(1)|ovary(2)|upper_aerodigestive_tract(1)	10						TGGGAAAATCTGGGGGGGTGTT	0.490			T	BCL6	NHL								7	68	---	---	---	---					
STAT6	6778	broad.mit.edu	37	12	57499093	57499094	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr12:57499093_57499094insG	ENST00000300134.3	-	9	1166_1167	c.841_842insC	c.(841-843)ggtfs	p.G281fs	STAT6_ENST00000537215.2_Frame_Shift_Ins_p.G171fs|STAT6_ENST00000454075.3_Frame_Shift_Ins_p.G281fs|STAT6_ENST00000543873.2_Frame_Shift_Ins_p.G281fs|STAT6_ENST00000538913.2_Frame_Shift_Ins_p.G171fs|STAT6_ENST00000556155.1_Frame_Shift_Ins_p.G281fs	NM_001178078.1|NM_003153.4	NP_001171549.1|NP_003144.3	P42226	STAT6_HUMAN	signal transducer and activator of transcription 6, interleukin-4 induced	281					regulation of transcription from RNA polymerase II promoter	cytosol|nucleus	calcium ion binding|DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			breast(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(5)|kidney(2)|large_intestine(2)|lung(8)|ovary(4)|skin(1)	28						CTTCAGTACCTGGGGGGGCTGC	0.639													10	109	---	---	---	---					
GLI1	2735	broad.mit.edu	37	12	57860074	57860075	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr12:57860074_57860075insG	ENST00000228682.2	+	8	905_906	c.814_815insG	c.(814-816)gggfs	p.G272fs	GLI1_ENST00000543426.1_Frame_Shift_Ins_p.G144fs|GLI1_ENST00000546141.1_Frame_Shift_Ins_p.G231fs	NM_005269.2	NP_005260.1	P08151	GLI1_HUMAN	GLI family zinc finger 1	272					epidermal cell differentiation|negative regulation of canonical Wnt receptor signaling pathway|osteoblast differentiation|positive regulation of DNA replication|positive regulation of smoothened signaling pathway|positive regulation of transcription from RNA polymerase II promoter	cytosol|nucleus	transcription regulatory region DNA binding|zinc ion binding			NS(1)|breast(7)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(8)|lung(22)|ovary(6)|pancreas(2)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	69			GBM - Glioblastoma multiforme(3;3.99e-32)			CGTGTGCCACTGGGGGGGCTGC	0.599													20	429	---	---	---	---					
IRAK3	11213	broad.mit.edu	37	12	66610953	66610954	+	Frame_Shift_Ins	INS	-	-	A			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr12:66610953_66610954insA	ENST00000261233.4	+	6	1012_1013	c.591_592insA	c.(589-594)gaaaaafs	p.EK197fs	IRAK3_ENST00000457197.2_Frame_Shift_Ins_p.EK136fs	NM_007199.2	NP_009130.2	Q9Y616	IRAK3_HUMAN	interleukin-1 receptor-associated kinase 3	197	Protein kinase.				interleukin-1-mediated signaling pathway|MyD88-dependent toll-like receptor signaling pathway|negative regulation of innate immune response|negative regulation of interleukin-12 production|negative regulation of interleukin-6 production|negative regulation of macrophage cytokine production|negative regulation of MAP kinase activity|negative regulation of NF-kappaB transcription factor activity|negative regulation of protein catabolic process|negative regulation of protein complex disassembly|negative regulation of toll-like receptor signaling pathway|negative regulation of tumor necrosis factor production|positive regulation of macrophage tolerance induction|positive regulation of NF-kappaB transcription factor activity|response to exogenous dsRNA|response to lipopolysaccharide|response to peptidoglycan	cytoplasm|nucleus	ATP binding|magnesium ion binding|protein heterodimerization activity|protein homodimerization activity|protein serine/threonine kinase activity			breast(3)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(17)|ovary(2)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	36				GBM - Glioblastoma multiforme(28;0.0203)		ATATGTAGGAGAAAAAAATGCA	0.361													7	773	---	---	---	---					
TMCC3	57458	broad.mit.edu	37	12	94975857	94975858	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr12:94975857_94975858insG	ENST00000261226.4	-	2	666_667	c.535_536insC	c.(535-537)ttgfs	p.L179fs	TMCC3_ENST00000551457.1_Frame_Shift_Ins_p.L148fs	NM_020698.2	NP_065749.2	Q9ULS5	TMCC3_HUMAN	transmembrane and coiled-coil domain family 3	179						integral to membrane				NS(1)|breast(3)|endometrium(2)|kidney(2)|large_intestine(8)|lung(10)|ovary(1)|skin(1)|urinary_tract(1)	29						CTCCATGCAATGGGGGGCAGTT	0.495													8	190	---	---	---	---					
MSI1	4440	broad.mit.edu	37	12	120800902	120800903	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr12:120800902_120800903insC	ENST00000257552.2	-	6	433_434	c.345_346insG	c.(343-348)ggtgtcfs	p.V116fs		NM_002442.3	NP_002433.1	O43347	MSI1H_HUMAN	musashi RNA-binding protein 1	116	RRM 2.				nervous system development	cytoplasm|nucleus	nucleotide binding			breast(4)|central_nervous_system(2)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(5)|skin(2)	19	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					TTCACCGACAGCCCCCCCACAA	0.564													12	245	---	---	---	---					
ATP12A	479	broad.mit.edu	37	13	25262563	25262564	+	Frame_Shift_Ins	INS	-	-	G	rs35191129		TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr13:25262563_25262564insG	ENST00000218548.6	+	4	668_669	c.335_336insG	c.(334-336)gggfs	p.G112fs	ATP12A_ENST00000381946.3_Frame_Shift_Ins_p.G112fs	NM_001185085.1|NM_001676.5	NP_001172014.1|NP_001667.4	P54707	AT12A_HUMAN	ATPase, H+/K+ transporting, nongastric, alpha polypeptide	112					ATP biosynthetic process	hydrogen:potassium-exchanging ATPase complex	ATP binding|hydrogen:potassium-exchanging ATPase activity|metal ion binding	p.V112V(1)		breast(6)|central_nervous_system(4)|endometrium(3)|kidney(5)|large_intestine(23)|lung(23)|ovary(2)|pancreas(1)|prostate(2)|skin(5)	74		Lung SC(185;0.0225)|Breast(139;0.077)		all cancers(112;0.0307)|Epithelial(112;0.086)|OV - Ovarian serous cystadenocarcinoma(117;0.228)	Esomeprazole(DB00736)|Pantoprazole(DB00213)	AAGCAGATGGTGGGGGGGTTCT	0.584													43	1285	---	---	---	---					
OR4N5	390437	broad.mit.edu	37	14	20612063	20612064	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr14:20612063_20612064insC	ENST00000333629.1	+	1	169_170	c.169_170insC	c.(169-171)cccfs	p.P57fs		NM_001004724.1	NP_001004724.1	Q8IXE1	OR4N5_HUMAN	olfactory receptor, family 4, subfamily N, member 5	57					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|lung(23)|ovary(1)|skin(2)|urinary_tract(1)	29	all_cancers(95;0.00108)		Epithelial(56;7.58e-07)|all cancers(55;3.84e-06)	GBM - Glioblastoma multiforme(265;0.0143)		TGGGCTCACAGCCCCCCTCTAT	0.460													7	859	---	---	---	---					
FNTB	2342	broad.mit.edu	37	14	65520040	65520041	+	Frame_Shift_Ins	INS	-	-	G	rs149471226		TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr14:65520040_65520041insG	ENST00000246166.2	+	10	1274_1275	c.1040_1041insG	c.(1039-1041)gggfs	p.G347fs	CHURC1-FNTB_ENST00000448390.2_Frame_Shift_Ins_p.G103fs|CHURC1-FNTB_ENST00000542227.1_Frame_Shift_Ins_p.G301fs|CHURC1-FNTB_ENST00000447296.2_Frame_Shift_Ins_p.G381fs|MAX_ENST00000341653.2_Intron	NM_002028.3	NP_002019.1			farnesyltransferase, CAAX box, beta									p.A347A(1)		breast(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(2)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	14				all cancers(60;0.00115)|OV - Ovarian serous cystadenocarcinoma(108;0.00412)|BRCA - Breast invasive adenocarcinoma(234;0.011)		CAGTGCCCTGCGGGGGGGCTTC	0.599													8	50	---	---	---	---					
GALNT16	57452	broad.mit.edu	37	14	69800299	69800300	+	Frame_Shift_Ins	INS	-	-	G	rs144140025		TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr14:69800299_69800300insG	ENST00000337827.4	+	9	1276_1277	c.949_950insG	c.(949-951)gggfs	p.G317fs	GALNT16_ENST00000448469.3_Frame_Shift_Ins_p.G317fs|GALNT16_ENST00000553669.1_Frame_Shift_Ins_p.G317fs	NM_001168368.1|NM_020692.2	NP_001161840.1|NP_065743.2			UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 16																		GATGGACATCTGGGGGGGAGAG	0.470													7	151	---	---	---	---					
ELMSAN1	91748	broad.mit.edu	37	14	74206605	74206606	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr14:74206605_74206606insG	ENST00000286523.5	-	2	888_889	c.106_107insC	c.(106-108)gcafs	p.A36fs	ELMSAN1_ENST00000394071.2_Frame_Shift_Ins_p.A36fs	NM_194278.3	NP_919254.2			ELM2 and Myb/SANT-like domain containing 1																		GATGGACTGCTGGGGGGGCTGC	0.668													7	95	---	---	---	---					
OR4M2	390538	broad.mit.edu	37	15	22369023	22369024	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr15:22369023_22369024insG	ENST00000332663.2	+	1	546_547	c.448_449insG	c.(448-450)gggfs	p.G150fs	RP11-69H14.6_ENST00000558896.1_RNA	NM_001004719.2	NP_001004719.2	Q8NGB6	OR4M2_HUMAN	olfactory receptor, family 4, subfamily M, member 2	150					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.R150M(2)|p.R150W(1)		NS(2)|endometrium(2)|kidney(4)|large_intestine(6)|lung(38)|ovary(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(3)	63		all_cancers(20;1.94e-20)|all_epithelial(15;3.94e-18)|Lung NSC(15;8.53e-15)|all_lung(15;2.87e-14)|Breast(32;0.00519)|Colorectal(260;0.101)	GBM - Glioblastoma multiforme(6;0.124)	all cancers(64;1.64e-11)|Epithelial(43;5.81e-10)|BRCA - Breast invasive adenocarcinoma(123;0.000255)|Kidney(6;0.00736)|KIRC - Kidney renal clear cell carcinoma(6;0.0135)|GBM - Glioblastoma multiforme(186;0.0963)		TCTCTCCTGGAGGGGGGGCTTC	0.500													18	527	---	---	---	---					
HERC2	8924	broad.mit.edu	37	15	28478873	28478874	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr15:28478873_28478874insG	ENST00000261609.7	-	28	4395_4396	c.4287_4288insC	c.(4285-4290)ccagcafs	p.A1430fs		NM_004667.5	NP_004658.3	O95714	HERC2_HUMAN	HECT and RLD domain containing E3 ubiquitin protein ligase 2	1430					DNA repair|intracellular protein transport|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	guanyl-nucleotide exchange factor activity|heme binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding	p.P1429P(1)		NS(1)|autonomic_ganglia(1)|breast(3)|central_nervous_system(3)|cervix(3)|endometrium(20)|kidney(11)|large_intestine(33)|lung(95)|ovary(7)|prostate(8)|skin(7)|upper_aerodigestive_tract(8)|urinary_tract(4)	204		all_lung(180;1.3e-11)|Breast(32;0.000194)|Colorectal(260;0.227)		all cancers(64;3.93e-09)|Epithelial(43;9.99e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0271)|GBM - Glioblastoma multiforme(186;0.0497)|Lung(196;0.199)		ACGGGATGCTCGGGGGGAAACA	0.450													7	135	---	---	---	---					
C15orf52	388115	broad.mit.edu	37	15	40630771	40630772	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr15:40630771_40630772insG	ENST00000559313.1	-	5	624_625	c.609_610insC	c.(607-612)cccgcafs	p.A204fs		NM_207380.2	NP_997263.2	Q6ZUT6	CO052_HUMAN	chromosome 15 open reading frame 52	204										central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(9)|urinary_tract(1)	19		all_cancers(109;9.35e-19)|all_epithelial(112;1.18e-15)|Lung NSC(122;2.45e-11)|all_lung(180;6.47e-10)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;9.06e-06)|Colorectal(105;0.0107)|BRCA - Breast invasive adenocarcinoma(123;0.0505)|READ - Rectum adenocarcinoma(2;0.0649)|Lung(196;0.0781)|LUAD - Lung adenocarcinoma(183;0.0841)		GCCACCTGCGTGGGGGGGCTTC	0.584											OREG0023060	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	7	156	---	---	---	---					
ACSM2B	348158	broad.mit.edu	37	16	20556547	20556548	+	Frame_Shift_Ins	INS	-	-	G	rs146499503		TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr16:20556547_20556548insG	ENST00000329697.6	-	10	1380_1381	c.1212_1213insC	c.(1210-1215)ccgcacfs	p.H405fs	ACSM2B_ENST00000567288.1_5'UTR|ACSM2B_ENST00000565322.1_Frame_Shift_Ins_p.H326fs|ACSM2B_ENST00000567001.1_Frame_Shift_Ins_p.H405fs|ACSM2B_ENST00000565232.1_Frame_Shift_Ins_p.H405fs	NM_001105069.1	NP_001098539.1	Q68CK6	ACS2B_HUMAN	acyl-CoA synthetase medium-chain family member 2B	405					fatty acid metabolic process|xenobiotic metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|CoA-ligase activity|metal ion binding			breast(4)|central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(4)|lung(33)|ovary(1)|prostate(1)|skin(5)	57						CCTTCTGTGCCGGGGGGCAGGA	0.515													9	191	---	---	---	---					
DNAH3	55567	broad.mit.edu	37	16	21063027	21063028	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr16:21063027_21063028insG	ENST00000261383.3	-	29	4200_4201	c.4201_4202insC	c.(4201-4203)gctfs	p.A1401fs	DNAH3_ENST00000415178.1_Frame_Shift_Ins_p.A1401fs	NM_017539.1	NP_060009.1	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	1401	AAA 1 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(3)|autonomic_ganglia(1)|breast(12)|central_nervous_system(3)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(42)|liver(2)|lung(57)|ovary(14)|pancreas(1)|prostate(7)|skin(11)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(6)	202				GBM - Glioblastoma multiforme(48;0.207)		GATCACCAGCCGGGGGGAGTTT	0.569													12	289	---	---	---	---					
ARHGAP17	55114	broad.mit.edu	37	16	24942179	24942180	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr16:24942179_24942180insG	ENST00000289968.6	-	19	2509_2510	c.2440_2441insC	c.(2440-2442)accfs	p.T814fs	ARHGAP17_ENST00000441763.2_3'UTR|ARHGAP17_ENST00000303665.5_Frame_Shift_Ins_p.T736fs	NM_001006634.1	NP_001006635.1	Q68EM7	RHG17_HUMAN	Rho GTPase activating protein 17	814	Pro-rich.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|tight junction	GTPase activator activity|SH3 domain binding			breast(2)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(3)|lung(13)|ovary(1)|urinary_tract(2)	30				GBM - Glioblastoma multiforme(48;0.0407)		ACCAGGAGGTTGGGGGGGTGGG	0.574													8	95	---	---	---	---					
TBX6	6911	broad.mit.edu	37	16	30100077	30100078	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr16:30100077_30100078insC	ENST00000553607.1	-	4	1397_1398	c.704_705insG	c.(703-705)gatfs	p.D235fs	TBX6_ENST00000395224.2_Frame_Shift_Ins_p.D235fs|TBX6_ENST00000279386.2_Frame_Shift_Ins_p.D235fs			O95947	TBX6_HUMAN	T-box 6	235					anatomical structure morphogenesis|mesoderm development|multicellular organismal development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(1)|lung(2)|ovary(1)|pancreas(1)	9						AGGAGGCCATGCCCCCCCAGTG	0.629													8	131	---	---	---	---					
MT4	84560	broad.mit.edu	37	16	56602768	56602769	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr16:56602768_56602769insC	ENST00000219162.3	+	3	193_194	c.113_114insC	c.(112-114)tccfs	p.S38fs		NM_032935.2	NP_116324.1	P47944	MT4_HUMAN	metallothionein 4	38						cytoplasm	copper ion binding|zinc ion binding			ovary(1)|upper_aerodigestive_tract(1)	2						TGTCCCTGCTGCCCCCCGGGCT	0.599													17	633	---	---	---	---					
CLEC3A	10143	broad.mit.edu	37	16	78090272	78090272	+	RNA	DEL	G	G	-			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr16:78090272delG	ENST00000563114.1	-	0	41																											CAGGCAGGGTGGCCAGCTTGC	0.527													2	4	---	---	---	---					
ALOX12	239	broad.mit.edu	37	17	6903739	6903740	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr17:6903739_6903740insC	ENST00000251535.6	+	7	945_946	c.892_893insC	c.(892-894)cccfs	p.P298fs	AC027763.2_ENST00000574377.1_Intron|RP11-589P10.7_ENST00000572547.1_RNA|AC027763.2_ENST00000575727.1_Intron|AC027763.2_ENST00000399541.2_Intron	NM_000697.2	NP_000688.2	P18054	LOX12_HUMAN	arachidonate 12-lipoxygenase	298	Lipoxygenase.		A -> T.		anti-apoptosis|cellular component movement|fatty acid oxidation|leukotriene biosynthetic process|positive regulation of cell adhesion|positive regulation of cell growth|positive regulation of cell proliferation|superoxide anion generation	cytosol|sarcolemma	arachidonate 12-lipoxygenase activity|hepoxilin-epoxide hydrolase activity|iron ion binding|lipoxygenase activity|protein binding			breast(2)|central_nervous_system(1)|endometrium(3)|large_intestine(4)|lung(4)|ovary(1)|prostate(3)|urinary_tract(1)	19						ATACCTGGCTGCCCCCCTCGTT	0.554													7	671	---	---	---	---					
EFNB3	1949	broad.mit.edu	37	17	7612855	7612856	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr17:7612855_7612856insC	ENST00000226091.2	+	5	1381_1382	c.984_985insC	c.(982-987)ggccccfs	p.GP328fs		NM_001406.3	NP_001397.1	Q15768	EFNB3_HUMAN	ephrin-B3	328					cell-cell signaling|interspecies interaction between organisms	integral to plasma membrane	ephrin receptor binding|transmembrane-ephrin receptor activity			large_intestine(3)|lung(2)|ovary(1)|prostate(1)|urinary_tract(1)	8		all_cancers(10;1.14e-06)|Prostate(122;0.081)				TGCAGGATGGGCCCCCCCAGAG	0.574													9	158	---	---	---	---					
SSH2	85464	broad.mit.edu	37	17	27963294	27963295	+	Frame_Shift_Ins	INS	-	-	G	rs35554312		TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr17:27963294_27963295insG	ENST00000269033.3	-	14	2023_2024	c.1872_1873insC	c.(1870-1875)cctgtcfs	p.V625fs	RP11-68I3.2_ENST00000581474.1_RNA|SSH2_ENST00000540801.1_Frame_Shift_Ins_p.V652fs	NM_033389.2	NP_203747.2	Q76I76	SSH2_HUMAN	slingshot protein phosphatase 2	625					actin cytoskeleton organization|regulation of actin polymerization or depolymerization|regulation of axonogenesis|regulation of lamellipodium assembly	cytoplasm|cytoskeleton	actin binding|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity		SSH2/SUZ12(2)	breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(5)|lung(16)|ovary(1)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	39						TCAGGGGACATGGGGGGGTCTT	0.470													10	192	---	---	---	---					
ACACA	31	broad.mit.edu	37	17	35600370	35600371	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr17:35600370_35600371insG	ENST00000353139.5	-	22	3328_3329	c.2847_2848insC	c.(2845-2850)ccatgtfs	p.C950fs	ACACA_ENST00000335166.5_Frame_Shift_Ins_p.C835fs|ACACA_ENST00000360679.3_Frame_Shift_Ins_p.C855fs|ACACA_ENST00000394406.2_Frame_Shift_Ins_p.C913fs	NM_198834.1|NM_198839.1	NP_942131.1|NP_942136.1	Q13085	ACACA_HUMAN	acetyl-CoA carboxylase alpha	913					acetyl-CoA metabolic process|energy reserve metabolic process|fatty acid biosynthetic process|long-chain fatty-acyl-CoA biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|triglyceride biosynthetic process	cytosol	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			NS(2)|breast(5)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(24)|lung(23)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	83		Breast(25;0.00157)|Ovarian(249;0.15)			Biotin(DB00121)	TTCTCCACATTGGGGGGAATGC	0.470													8	514	---	---	---	---					
CDK12	51755	broad.mit.edu	37	17	37687471	37687472	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr17:37687471_37687472insG	ENST00000447079.4	+	14	4408_4409	c.4375_4376insG	c.(4375-4377)gggfs	p.G1459fs	CDK12_ENST00000430627.2_Frame_Shift_Ins_p.G1450fs	NM_015083.1|NM_016507.2	NP_055898.1|NP_057591.2	Q9NYV4	CDK12_HUMAN	cyclin-dependent kinase 12	1459					mRNA processing|phosphorylation of RNA polymerase II C-terminal domain|protein autophosphorylation|regulation of MAP kinase activity|RNA splicing	nuclear cyclin-dependent protein kinase holoenzyme complex|nuclear speck|nucleolus	ATP binding|cyclin-dependent protein kinase activity|protein binding|RNA polymerase II carboxy-terminal domain kinase activity			NS(4)|breast(3)|endometrium(5)|kidney(4)|large_intestine(11)|lung(23)|ovary(11)|prostate(4)|skin(2)|urinary_tract(3)	70						AGGCCTTCACTGGGGGGGCCCA	0.559			"""Mis, N, F"""		serous ovarian					TCGA Ovarian(9;0.13)			8	106	---	---	---	---					
KRT26	353288	broad.mit.edu	37	17	38926341	38926342	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr17:38926341_38926342insC	ENST00000335552.4	-	4	762_763	c.714_715insG	c.(712-717)ggacgtfs	p.R239fs		NM_181539.4	NP_853517.2	Q7Z3Y9	K1C26_HUMAN	keratin 26	239	Linker 12.|Rod.					intermediate filament	structural molecule activity			central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(5)	16		Breast(137;0.00526)				ACGTTCACGTTCCCCCCAGCTG	0.480													7	237	---	---	---	---					
KCNH4	23415	broad.mit.edu	37	17	40328258	40328259	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr17:40328258_40328259insC	ENST00000264661.3	-	5	974_975	c.642_643insG	c.(640-645)ggctcgfs	p.S215fs	KCNH4_ENST00000607371.1_Frame_Shift_Ins_p.S215fs	NM_012285.2	NP_036417.1	Q9UQ05	KCNH4_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 4	215					regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	two-component sensor activity|voltage-gated potassium channel activity			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(6)|lung(15)|skin(2)|urinary_tract(1)	32		all_cancers(22;1.24e-06)|all_epithelial(22;4.33e-05)|Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.126)		AGGCAGCGAGACCCCCCCACGG	0.604													11	316	---	---	---	---					
MTMR4	9110	broad.mit.edu	37	17	56590245	56590246	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr17:56590245_56590246insG	ENST00000323456.5	-	3	184_185	c.60_61insC	c.(58-63)ccaggafs	p.G21fs	MTMR4_ENST00000579925.1_Frame_Shift_Ins_p.G21fs	NM_004687.4	NP_004678.3	Q9NYA4	MTMR4_HUMAN	myotubularin related protein 4	21						cytoplasm|membrane	metal ion binding|protein tyrosine phosphatase activity	p.K21fs*20(1)		breast(10)|endometrium(2)|kidney(2)|large_intestine(5)|lung(12)|skin(5)	36	Medulloblastoma(34;0.127)|all_neural(34;0.237)					ACTAGTTCCTTGGGGGGGAACA	0.569													7	111	---	---	---	---					
MARCH10	162333	broad.mit.edu	37	17	60814265	60814266	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr17:60814265_60814266insC	ENST00000544856.2	-	7	1338_1339	c.960_961insG	c.(958-963)ggcatcfs	p.I321fs	MARCH10_ENST00000311269.5_Frame_Shift_Ins_p.I322fs|RP11-156L14.1_ENST00000582564.1_RNA|RP11-156L14.1_ENST00000577270.1_RNA|MARCH10_ENST00000456609.2_Frame_Shift_Ins_p.I322fs|MARCH10_ENST00000583600.1_Frame_Shift_Ins_p.I360fs			Q8NA82	MARHA_HUMAN	membrane-associated ring finger (C3HC4) 10, E3 ubiquitin protein ligase	322							ligase activity|zinc ion binding			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(11)|liver(1)|lung(15)	38						GGGGTCGATGTCCCCCCAAATC	0.460													10	755	---	---	---	---					
ABCA6	23460	broad.mit.edu	37	17	67083603	67083604	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr17:67083603_67083604insG	ENST00000284425.2	-	29	3883_3884	c.3709_3710insC	c.(3709-3711)aagfs	p.K1237fs	ABCA6_ENST00000446604.2_5'UTR	NM_080284.2	NP_525023.2	Q8N139	ABCA6_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 6	1237					transport	integral to membrane	ATP binding|ATPase activity			breast(6)|endometrium(5)|kidney(17)|large_intestine(18)|lung(20)|ovary(3)|prostate(2)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	82	Breast(10;5.65e-12)					ATCTCTACTTTGGGGGGAAATT	0.376													10	709	---	---	---	---					
FAM104A	84923	broad.mit.edu	37	17	71223356	71223357	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr17:71223356_71223357insG	ENST00000405159.3	-	2	332_333	c.268_269insC	c.(268-270)gacfs	p.D90fs	FAM104A_ENST00000583024.1_Intron|FAM104A_ENST00000581110.1_Intron|FAM104A_ENST00000583178.1_5'UTR|FAM104A_ENST00000580032.1_5'UTR|FAM104A_ENST00000403627.3_Frame_Shift_Ins_p.D90fs	NM_001098832.1	NP_001092302.1	Q969W3	F104A_HUMAN	family with sequence similarity 104, member A	90										endometrium(1)|kidney(1)|large_intestine(1)|lung(3)	6			LUSC - Lung squamous cell carcinoma(166;0.197)			TCTTTTGGTCTGGGGGGGAAGA	0.416													9	198	---	---	---	---					
PTBP1	5725	broad.mit.edu	37	19	797500	797500	+	Translation_Start_Site	DEL	G	G	-			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr19:797500delG	ENST00000356948.6	+	0	426				PTBP1_ENST00000394601.4_Start_Codon_Del|PTBP1_ENST00000349038.4_Start_Codon_Del|PTBP1_ENST00000350092.4_Start_Codon_Del	NM_002819.4	NP_002810.1	P26599	PTBP1_HUMAN	polypyrimidine tract binding protein 1						negative regulation of muscle cell differentiation|nuclear mRNA splicing, via spliceosome|regulation of alternative nuclear mRNA splicing, via spliceosome	heterogeneous nuclear ribonucleoprotein complex|nucleolus|nucleoplasm	mRNA binding|nucleotide binding|poly-pyrimidine tract binding|protein binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(4)|ovary(1)|skin(2)|upper_aerodigestive_tract(4)	19		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;6.59e-06)|all_lung(49;9.97e-06)|Breast(49;0.000172)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TGTGTGCCATGGACGGGTGAG	0.736													2	4	---	---	---	---					
C3	718	broad.mit.edu	37	19	6697480	6697481	+	Frame_Shift_Ins	INS	-	-	G	rs137956083		TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr19:6697480_6697481insG	ENST00000245907.6	-	21	2762_2763	c.2670_2671insC	c.(2668-2673)ccagtcfs	p.V891fs		NM_000064.2	NP_000055.2	P01024	CO3_HUMAN	complement component 3	891					complement activation, alternative pathway|complement activation, classical pathway|G-protein coupled receptor protein signaling pathway|inflammatory response|positive regulation vascular endothelial growth factor production	extracellular space	endopeptidase inhibitor activity|receptor binding			breast(5)|endometrium(7)|kidney(6)|large_intestine(18)|liver(1)|lung(18)|ovary(1)|pancreas(1)|prostate(5)|skin(7)|upper_aerodigestive_tract(3)	72				GBM - Glioblastoma multiforme(1328;1.36e-05)|Lung(535;0.00661)		AACGAGGACTTGGGGGGGATGG	0.574													8	159	---	---	---	---					
SH2D3A	10045	broad.mit.edu	37	19	6754945	6754946	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr19:6754945_6754946insG	ENST00000245908.6	-	5	1146_1147	c.877_878insC	c.(877-879)gaafs	p.E293fs	SH2D3A_ENST00000437152.3_Frame_Shift_Ins_p.E171fs	NM_005490.2	NP_005481.2	Q9BRG2	SH23A_HUMAN	SH2 domain containing 3A	293					JNK cascade|small GTPase mediated signal transduction	intracellular	guanyl-nucleotide exchange factor activity|SH3/SH2 adaptor activity			breast(3)|endometrium(3)|kidney(1)|large_intestine(4)|lung(9)|skin(3)|urinary_tract(1)	24						GGGCCGATTCTGGGGGCCCAGC	0.599													7	356	---	---	---	---					
MUC16	94025	broad.mit.edu	37	19	9064309	9064310	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr19:9064309_9064310insG	ENST00000397910.4	-	3	23339_23340	c.23136_23137insC	c.(23134-23139)ccctccfs	p.S7713fs		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	7715	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GGAAGGGGAGAGGGGGGGATAT	0.530													8	285	---	---	---	---					
ANGPTL6	83854	broad.mit.edu	37	19	10204185	10204186	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr19:10204185_10204186insC	ENST00000253109.4	-	5	1299_1300	c.1061_1062insG	c.(1060-1062)gcgfs	p.A354fs	ANGPTL6_ENST00000592641.1_Frame_Shift_Ins_p.A354fs|ANGPTL6_ENST00000589181.1_Frame_Shift_Ins_p.A314fs	NM_031917.2	NP_114123.2	Q8NI99	ANGL6_HUMAN	angiopoietin-like 6	354	Fibrinogen C-terminal.				angiogenesis|cell differentiation|signal transduction	extracellular space	receptor binding			endometrium(1)|kidney(1)|large_intestine(2)|lung(6)|ovary(1)|pancreas(1)	12			OV - Ovarian serous cystadenocarcinoma(20;3.58e-08)|Epithelial(33;2.5e-05)|all cancers(31;5.96e-05)			GTGCTCCACGGCCCCCCCAGTC	0.639													7	57	---	---	---	---					
TSHZ3	57616	broad.mit.edu	37	19	31769061	31769062	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr19:31769061_31769062insC	ENST00000240587.4	-	2	1964_1965	c.1637_1638insG	c.(1636-1638)gtafs	p.V546fs		NM_020856.2	NP_065907.2	Q63HK5	TSH3_HUMAN	teashirt zinc finger homeobox 3	546					negative regulation of transcription, DNA-dependent|regulation of respiratory gaseous exchange by neurological system process	growth cone|nucleus	chromatin binding|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(4)|endometrium(15)|kidney(9)|large_intestine(20)|lung(60)|ovary(4)|pancreas(2)|prostate(4)|skin(5)	123	Esophageal squamous(110;0.226)					TGCTGGGATAGCCCCCCCAGCT	0.559													10	188	---	---	---	---					
TSHZ3	57616	broad.mit.edu	37	19	31769141	31769142	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr19:31769141_31769142insC	ENST00000240587.4	-	2	1884_1885	c.1557_1558insG	c.(1555-1560)ggttgafs	p.*520fs		NM_020856.2	NP_065907.2	Q63HK5	TSH3_HUMAN	teashirt zinc finger homeobox 3	520					negative regulation of transcription, DNA-dependent|regulation of respiratory gaseous exchange by neurological system process	growth cone|nucleus	chromatin binding|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(4)|endometrium(15)|kidney(9)|large_intestine(20)|lung(60)|ovary(4)|pancreas(2)|prostate(4)|skin(5)	123	Esophageal squamous(110;0.226)					AGGATATCAAGCCCCCCCTTGG	0.500													15	355	---	---	---	---					
PSG7	5676	broad.mit.edu	37	19	43439519	43439520	+	RNA	INS	-	-	C	rs59911953	by1000genomes	TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr19:43439519_43439520insC	ENST00000406070.2	-	0	527				PSG7_ENST00000446844.3_RNA	NM_002783.2	NP_002774.2	Q13046	PSG7_HUMAN	pregnancy specific beta-1-glycoprotein 7 (gene/pseudogene)						female pregnancy	extracellular region							Prostate(69;0.00682)				AATGACCCCTGCCCCCCAACAC	0.515													13	637	---	---	---	---					
TEAD2	8463	broad.mit.edu	37	19	49850472	49850473	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr19:49850472_49850473insG	ENST00000377214.4	-	8	1254_1255	c.892_893insC	c.(892-894)tgcfs	p.C298fs	TEAD2_ENST00000601519.1_Frame_Shift_Ins_p.C298fs|TEAD2_ENST00000593945.1_Frame_Shift_Ins_p.C299fs|TEAD2_ENST00000539846.1_Frame_Shift_Ins_p.C167fs|TEAD2_ENST00000598810.1_Frame_Shift_Ins_p.C299fs|TEAD2_ENST00000311227.2_Frame_Shift_Ins_p.C295fs			Q15562	TEAD2_HUMAN	TEA domain family member 2	295	Transcriptional activation (Potential).				hippo signaling cascade		DNA binding|protein binding|sequence-specific DNA binding transcription factor activity	p.H295fs*12(1)		central_nervous_system(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(12)|ovary(2)|prostate(1)	29		all_lung(116;7.65e-05)|Lung NSC(112;0.000132)|all_neural(266;0.0506)|Ovarian(192;0.15)		OV - Ovarian serous cystadenocarcinoma(262;0.00093)|GBM - Glioblastoma multiforme(486;0.0467)		GAAGAAGGCATGGGGGGGGCCA	0.564													20	331	---	---	---	---					
TSKS	60385	broad.mit.edu	37	19	50243063	50243064	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr19:50243063_50243064insG	ENST00000246801.3	-	11	1830_1831	c.1748_1749insC	c.(1747-1749)caafs	p.Q583fs	TSKS_ENST00000358830.3_Frame_Shift_Ins_p.Q383fs	NM_021733.1	NP_068379.1	Q9UJT2	TSKS_HUMAN	testis-specific serine kinase substrate	583							protein binding			breast(3)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(12)|liver(1)|lung(9)|prostate(3)|skin(3)	38		all_lung(116;3.24e-07)|Lung NSC(112;1.6e-06)|all_neural(266;0.0459)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.00153)|GBM - Glioblastoma multiforme(134;0.0145)		CCCCCTGTTTTGGGGGGGTTCC	0.545													11	243	---	---	---	---					
GPR32	2854	broad.mit.edu	37	19	51274914	51274915	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr19:51274914_51274915insC	ENST00000270590.4	+	1	1194_1195	c.1057_1058insC	c.(1057-1059)cccfs	p.P353fs		NM_001506.1	NP_001497.1	O75388	GPR32_HUMAN	G protein-coupled receptor 32	353						integral to plasma membrane	N-formyl peptide receptor activity			breast(4)|endometrium(4)|kidney(1)|large_intestine(3)|lung(12)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	29		all_neural(266;0.131)		OV - Ovarian serous cystadenocarcinoma(262;0.00641)|GBM - Glioblastoma multiforme(134;0.028)		CCGTGGCAACGCCCCCCGGGAA	0.525													7	127	---	---	---	---					
KLK1	3816	broad.mit.edu	37	19	51326962	51326963	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr19:51326962_51326963insC	ENST00000301420.2	-	1	77_78	c.42_43insG	c.(40-45)ggctggfs	p.W15fs	KLK1_ENST00000448701.2_5'UTR	NM_002257.2	NP_002248.1	P06870	KLK1_HUMAN	kallikrein 1	15					proteolysis	nucleus	serine-type endopeptidase activity			breast(1)|large_intestine(4)|lung(7)|urinary_tract(1)	13		all_neural(266;0.0199)		OV - Ovarian serous cystadenocarcinoma(262;0.00224)|GBM - Glioblastoma multiforme(134;0.00399)	Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GTCTCACCAGTCCCCCCCAGGG	0.653													9	215	---	---	---	---					
NRSN2	80023	broad.mit.edu	37	20	333922	333923	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr20:333922_333923insC	ENST00000382291.3	+	4	498_499	c.258_259insC	c.(256-261)gtccccfs	p.VP86fs	NRSN2_ENST00000492242.1_3'UTR|NRSN2_ENST00000382285.2_Frame_Shift_Ins_p.VP86fs	NM_024958.2	NP_079234.1	Q9GZP1	NRSN2_HUMAN	neurensin 2	86						integral to membrane|plasma membrane|transport vesicle				endometrium(1)|large_intestine(2)|lung(4)|urinary_tract(1)	8		all_cancers(10;0.0834)				GCTATGCAGTGCCCCCCAAGCT	0.644													11	277	---	---	---	---					
CST4	1472	broad.mit.edu	37	20	23667825	23667826	+	Frame_Shift_Ins	INS	-	-	C	rs140501583		TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr20:23667825_23667826insC	ENST00000217423.3	-	2	311_312	c.241_242insG	c.(241-243)gaafs	p.E81fs		NM_001899.2	NP_001890.1	P01036	CYTS_HUMAN	cystatin S	81						extracellular region	cysteine-type endopeptidase inhibitor activity			breast(1)|endometrium(1)|large_intestine(2)|lung(10)|skin(1)|upper_aerodigestive_tract(1)	16	Lung NSC(19;0.0789)|Colorectal(13;0.0993)|all_lung(19;0.169)					GAAGTAATTCACCCCCCCAAAG	0.554													10	194	---	---	---	---					
CNBD2	140894	broad.mit.edu	37	20	34618503	34618504	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr20:34618503_34618504insC	ENST00000373973.3	+	12	1837_1838	c.1664_1665insC	c.(1663-1665)cccfs	p.P555fs	CNBD2_ENST00000538900.1_3'UTR|CNBD2_ENST00000349339.1_Frame_Shift_Ins_p.P551fs					cyclic nucleotide binding domain containing 2																		CAGAAATACCTCCCCCCATTGA	0.455													7	637	---	---	---	---					
SLPI	6590	broad.mit.edu	37	20	43881730	43881731	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr20:43881730_43881731insG	ENST00000338380.2	-	3	326_327	c.306_307insC	c.(304-309)ccatttfs	p.F103fs		NM_003064.2	NP_003055.1	P03973	SLPI_HUMAN	secretory leukocyte peptidase inhibitor	103	Elastase inhibitory domain.|WAP 2.					extracellular region	serine-type endopeptidase inhibitor activity			lung(3)|ovary(1)	4		Myeloproliferative disorder(115;0.0122)				TCACAGAAATTGGGGGGGTTAA	0.535													11	249	---	---	---	---					
KCNB1	3745	broad.mit.edu	37	20	47989771	47989772	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr20:47989771_47989772insG	ENST00000371741.4	-	2	2491_2492	c.2325_2326insC	c.(2323-2328)ccaaagfs	p.PK775fs		NM_004975.2	NP_004966.1	Q14721	KCNB1_HUMAN	potassium voltage-gated channel, Shab-related subfamily, member 1	775					energy reserve metabolic process|regulation of insulin secretion	voltage-gated potassium channel complex	protein binding|voltage-gated potassium channel activity			central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(8)|liver(1)|lung(22)|pancreas(2)|prostate(7)|skin(4)|stomach(1)|urinary_tract(1)	53			BRCA - Breast invasive adenocarcinoma(12;0.000405)|COAD - Colon adenocarcinoma(4;0.14)|Colorectal(8;0.166)			GGGAGGCTTTTGGGGGGGCTGG	0.545													28	571	---	---	---	---					
OSBPL2	9885	broad.mit.edu	37	20	60854257	60854258	+	Frame_Shift_Ins	INS	-	-	C	rs79735057		TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr20:60854257_60854258insC	ENST00000313733.3	+	7	738_739	c.536_537insC	c.(535-537)cccfs	p.P179fs	OSBPL2_ENST00000439951.2_Frame_Shift_Ins_p.P87fs|OSBPL2_ENST00000358053.2_Frame_Shift_Ins_p.P167fs	NM_144498.1	NP_653081.1	Q9H1P3	OSBL2_HUMAN	oxysterol binding protein-like 2	179					lipid transport		lipid binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|large_intestine(2)|lung(8)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	17	Breast(26;7.76e-09)		BRCA - Breast invasive adenocarcinoma(19;1.33e-06)			GTCAGTCACCACCCCCCCATCA	0.465													12	144	---	---	---	---					
KRTAP26-1	388818	broad.mit.edu	37	21	31691917	31691918	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr21:31691917_31691918insG	ENST00000360542.3	-	1	689_690	c.436_437insC	c.(436-438)attfs	p.I146fs		NM_203405.1	NP_981950.1	Q6PEX3	KR261_HUMAN	keratin associated protein 26-1	146						intermediate filament				endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(7)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	16						CAAGCAGAATTGGGGGCGATAG	0.550													7	428	---	---	---	---					
CECR2	27443	broad.mit.edu	37	22	18022285	18022286	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr22:18022285_18022286insC	ENST00000262608.8	+	15	2390_2391	c.2390_2391insC	c.(2389-2391)gccfs	p.A797fs	CECR2_ENST00000400585.2_Frame_Shift_Ins_p.A655fs|CECR2_ENST00000400573.4_Frame_Shift_Ins_p.A796fs	NM_031413.3	NP_113601.2	Q9BXF3	CECR2_HUMAN	cat eye syndrome chromosome region, candidate 2	838					chromatin modification|cytokinesis|cytoskeleton organization|DNA fragmentation involved in apoptotic nuclear change|vesicle-mediated transport		protein binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(22)|ovary(1)|pancreas(1)|prostate(2)|skin(5)|stomach(1)|urinary_tract(1)	59		all_epithelial(15;0.139)		Lung(27;0.146)		AGACCACCTGTCCCCCCCAACC	0.609													7	127	---	---	---	---					
BMS1P20	96610	broad.mit.edu	37	22	22661173	22661174	+	RNA	INS	-	-	C	rs7410785		TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr22:22661173_22661174insC	ENST00000426066.1	+	0	265_266					NR_027293.1																						ATACAGGTTTTCCCCCCCCACC	0.406													10	88	---	---	---	---					
DDX17	10521	broad.mit.edu	37	22	38895454	38895455	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr22:38895454_38895455insC	ENST00000396821.3	-	3	587_588	c.488_489insG	c.(487-489)ggafs	p.G163fs	DDX17_ENST00000381633.3_Frame_Shift_Ins_p.G84fs|DDX17_ENST00000432525.1_5'UTR	NM_001098504.1|NM_006386.4	NP_001091974.1|NP_006377.2	Q92841	DDX17_HUMAN	DEAD (Asp-Glu-Ala-Asp) box helicase 17	84	Helicase ATP-binding.				RNA processing	nucleus	ATP binding|ATP-dependent helicase activity|RNA binding|RNA helicase activity|RNA-dependent ATPase activity	p.G163fs*20(1)		breast(1)|endometrium(1)|kidney(3)|large_intestine(9)|lung(6)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	25	Melanoma(58;0.0286)					GACAAACATCTCCCCCCCTCAC	0.381													10	163	---	---	---	---					
SSX3	10214	broad.mit.edu	37	X	48207024	48207025	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chrX:48207024_48207025insC	ENST00000298396.2	-	7	533_534	c.481_482insG	c.(481-483)acafs	p.T161fs	SSX3_ENST00000376895.1_Frame_Shift_Ins_p.T73fs	NM_021014.2	NP_066294.1	Q99909	SSX3_HUMAN	synovial sarcoma, X breakpoint 3	161					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding			endometrium(3)|large_intestine(1)|lung(9)	13						CCAGGCATGTTCCCCCCTTTTG	0.480													7	549	---	---	---	---					
LINC01317	104355287	broad.mit.edu	37	2	34441226	34441227	+	RNA	DEL	TG	TG	-	rs10701526		TCGA-AK-3443-01A-01D-0966-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3dc72bb8-02a6-41b1-a6d6-5c275a82f89b	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr2:34441226_34441227delTG	ENST00000366209.2	+	0	389																											gaagtgtatatgtgtgtgtgtg	0.470													2	4	---	---	---	---					
ENTPD3-AS1	285266	broad.mit.edu	37	3	40418607	40418610	+	RNA	DEL	AGGA	AGGA	-	rs112497421		TCGA-AK-3443-01A-01D-0966-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3dc72bb8-02a6-41b1-a6d6-5c275a82f89b	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr3:40418607_40418610delAGGA	ENST00000439293.1	-	0	143																											ggagggagggaggaaggaaggaag	0.554													5	6	---	---	---	---					
SEMA3B	7869	broad.mit.edu	37	3	50314241	50314241	+	RNA	DEL	T	T	-			TCGA-AK-3443-01A-01D-0966-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3dc72bb8-02a6-41b1-a6d6-5c275a82f89b	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr3:50314241delT	ENST00000418948.1	+	0	2588							Q13214	SEM3B_HUMAN	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B						axon guidance|cell-cell signaling	endoplasmic reticulum|extracellular region|membrane	receptor activity			central_nervous_system(2)|kidney(1)|lung(2)|skin(1)	6				BRCA - Breast invasive adenocarcinoma(193;0.000272)|KIRC - Kidney renal clear cell carcinoma(197;0.00544)|Kidney(197;0.00605)		ACATTGGGGGTCACCGGCCGA	0.622													2	4	---	---	---	---					
KIAA0408	9729	broad.mit.edu	37	6	127768325	127768329	+	Frame_Shift_Del	DEL	TTCTG	TTCTG	-			TCGA-AK-3443-01A-01D-0966-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3dc72bb8-02a6-41b1-a6d6-5c275a82f89b	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr6:127768325_127768329delTTCTG	ENST00000483725.3	-	5	1471_1475	c.1135_1139delCAGAA	c.(1135-1140)afs	p.QK379fs	SOGA3_ENST00000481848.2_3'UTR|SOGA3_ENST00000556132.1_3'UTR	NM_014702.4	NP_055517.3	Q6ZU52	K0408_HUMAN	KIAA0408	379							protein binding			endometrium(3)|large_intestine(7)|lung(15)|ovary(1)|pancreas(1)|skin(1)	28				GBM - Glioblastoma multiforme(226;0.0217)|all cancers(137;0.13)		AGAGCAGGTTTTCTGAAACCACGAA	0.434													9	273	---	---	---	---					
LINC01410	103352539	broad.mit.edu	37	9	66459739	66459740	+	RNA	INS	-	-	T	rs141706281		TCGA-AK-3443-01A-01D-0966-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3dc72bb8-02a6-41b1-a6d6-5c275a82f89b	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr9:66459739_66459740insT	ENST00000424345.1	+	0	67																											atttctttcagttttttttttt	0.292													5	4	---	---	---	---					
NPIPB3	23117	broad.mit.edu	37	16	21415876	21415894	+	Frame_Shift_Del	DEL	GCGGCCCCCGCAGACGCTC	GCGGCCCCCGCAGACGCTC	-			TCGA-AK-3443-01A-01D-0966-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3dc72bb8-02a6-41b1-a6d6-5c275a82f89b	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr16:21415876_21415894delGCGGCCCCCGCAGACGCTC	ENST00000458643.2	-	7	1365_1383	c.814_832delGAGCGTCTGCGGGGGCCGC	c.(814-834)ttfs	p.ERLRGPL272fs	NPIPB3_ENST00000448012.2_Frame_Shift_Del_p.PSVCGGR410fs|NPIPB3_ENST00000542817.1_Intron					nuclear pore complex interacting protein family, member B3																		GAGGGTGGAAGCGGCCCCCGCAGACGCTCGGCAGGTGTC	0.562													2	4	---	---	---	---					
LINC00669	647946	broad.mit.edu	37	18	37248431	37248454	+	RNA	DEL	AGGGAGGAAGGAAGGAAGGAAGGA	AGGGAGGAAGGAAGGAAGGAAGGA	-	rs141334489	by1000genomes	TCGA-AK-3443-01A-01D-0966-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3dc72bb8-02a6-41b1-a6d6-5c275a82f89b	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr18:37248431_37248454delAGGGAGGAAGGAAGGAAGGAAGGA	ENST00000591629.1	-	0	282					NR_024391.1																						ggagggagggagggaggaaggaaggaaggaaggaaggaaggaag	0.402													5	9	---	---	---	---					
BAGE2	85319	broad.mit.edu	37	21	11089271	11089273	+	RNA	DEL	CAC	CAC	-	rs150553952		TCGA-AK-3443-01A-01D-0966-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3dc72bb8-02a6-41b1-a6d6-5c275a82f89b	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr21:11089271_11089273delCAC	ENST00000470054.1	-	0	324									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		gtaatcccaacactttggaaggc	0.433													2	4	---	---	---	---					
LINC00229	414351	broad.mit.edu	37	22	45015083	45015084	+	RNA	DEL	GT	GT	-	rs71810069		TCGA-AK-3443-01A-01D-0966-08	TCGA-AK-3443-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3dc72bb8-02a6-41b1-a6d6-5c275a82f89b	b5d14d5a-4207-450e-9edb-106ab50ecbc7	g.chr22:45015083_45015084delGT	ENST00000443783.1	-	0	390					NR_044991.1																						gtactgtggagtgtgtgtgtgt	0.515													3	4	---	---	---	---					
MYT1L	23040	broad.mit.edu	37	2	1947094	1947094	+	Frame_Shift_Del	DEL	A	A	-			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	e9f65a55-337b-4a82-a85a-b0f9a68f599d	g.chr2:1947094delA	ENST00000399161.2	-	9	912	c.165delT	c.(163-165)tgfs	p.C55fs	MYT1L_ENST00000428368.2_Frame_Shift_Del_p.C55fs	NM_015025.2	NP_055840.2	Q9UL68	MYT1L_HUMAN	myelin transcription factor 1-like	55					cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(6)|large_intestine(16)|lung(50)|ovary(5)|prostate(2)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	97	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.037)|all_epithelial(98;0.241)		OV - Ovarian serous cystadenocarcinoma(76;0.169)|all cancers(51;0.244)		TCGCCAAGGGACAACCATATA	0.418													2	4	---	---	---	---					
OR10G8	219869	broad.mit.edu	37	11	123900396	123900397	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	e9f65a55-337b-4a82-a85a-b0f9a68f599d	g.chr11:123900396_123900397insC	ENST00000431524.1	+	1	100_101	c.67_68insC	c.(67-69)cccfs	p.P23fs		NM_001004464.1	NP_001004464.1	Q8NGN5	O10G8_HUMAN	olfactory receptor, family 10, subfamily G, member 8	23					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.A23T(1)		breast(1)|endometrium(7)|large_intestine(2)|lung(21)|ovary(1)|prostate(5)|skin(1)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	44		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0521)		AGCGCTGGACGCCCCCCTCTTT	0.589													7	504	---	---	---	---					
ROBO3	64221	broad.mit.edu	37	11	124750448	124750453	+	In_Frame_Del	DEL	CGGAGT	CGGAGT	-	rs55725290		TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	e9f65a55-337b-4a82-a85a-b0f9a68f599d	g.chr11:124750448_124750453delCGGAGT	ENST00000397801.1	+	27	4285_4290	c.4093_4098delCGGAGT	c.(4093-4098)del	p.RS1367del	ROBO3_ENST00000525482.1_3'UTR|ROBO3_ENST00000543966.1_In_Frame_Del_p.RS130del|ROBO3_ENST00000538940.1_In_Frame_Del_p.RS1345del	NM_022370.3	NP_071765.2	Q96MS0	ROBO3_HUMAN	roundabout, axon guidance receptor, homolog 3 (Drosophila)	1367					axon midline choice point recognition	integral to membrane	receptor activity			breast(2)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(17)|ovary(1)|prostate(3)|upper_aerodigestive_tract(1)	35	all_hematologic(175;0.215)	Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|Breast(109;0.0481)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.5e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0296)		TGgccggagccggagtcggagtcaga	0.660													9	4	---	---	---	---					
CLEC3A	10143	broad.mit.edu	37	16	78090272	78090272	+	RNA	DEL	G	G	-			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	e9f65a55-337b-4a82-a85a-b0f9a68f599d	g.chr16:78090272delG	ENST00000563114.1	-	0	41																											CAGGCAGGGTGGCCAGCTTGC	0.527													2	4	---	---	---	---					
CNTROB	116840	broad.mit.edu	37	17	7851879	7851880	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	e9f65a55-337b-4a82-a85a-b0f9a68f599d	g.chr17:7851879_7851880insG	ENST00000380262.3	+	17	3380_3381	c.2455_2456insG	c.(2455-2457)gggfs	p.G819fs	CNTROB_ENST00000380255.3_3'UTR|CNTROB_ENST00000563694.1_Frame_Shift_Ins_p.G819fs|CNTROB_ENST00000565740.1_Frame_Shift_Ins_p.G819fs	NM_001037144.5	NP_001032221.1	Q8N137	CNTRB_HUMAN	centrobin, centrosomal BRCA2 interacting protein	819	Required for centrosome localization.				centriole replication|centrosome separation|cytokinesis	centriole	protein domain specific binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(8)|lung(9)	25		Prostate(122;0.173)				GGCTCGGGGCTGGGGGGCTCTG	0.579													8	253	---	---	---	---					
AF038458.3	0	broad.mit.edu	37	19	36448398	36448398	+	RNA	DEL	T	T	-	rs35742682		TCGA-AK-3443-01A-01W-0886-08	TCGA-AK-3443-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99b7c42f-06e2-4ed9-83fa-954ef9993bf2	e9f65a55-337b-4a82-a85a-b0f9a68f599d	g.chr19:36448398delT	ENST00000592518.1	+	0	244																											ACCATAACCCttttttttttt	0.498													2	4	---	---	---	---					
PADI6	353238	broad.mit.edu	37	1	17699379	17699380	+	RNA	INS	-	-	AC	rs10690473	by1000genomes	TCGA-AK-3443-01A-01D-0966-08	TCGA-AK-3443-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3dc72bb8-02a6-41b1-a6d6-5c275a82f89b	e9f65a55-337b-4a82-a85a-b0f9a68f599d	g.chr1:17699379_17699380insAC	ENST00000434762.2	+	0	166							Q6TGC4	PADI6_HUMAN	peptidyl arginine deiminase, type VI						peptidyl-citrulline biosynthetic process from peptidyl-arginine	cytoplasm|nucleus	calcium ion binding|protein-arginine deiminase activity			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(9)|lung(9)|ovary(2)	29		Colorectal(325;3.46e-05)|Breast(348;0.000162)|all_lung(284;0.000337)|Lung NSC(340;0.000419)|Renal(390;0.000518)|Ovarian(437;0.00409)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00488)|BRCA - Breast invasive adenocarcinoma(304;7.59e-06)|COAD - Colon adenocarcinoma(227;1.18e-05)|Kidney(64;0.000186)|KIRC - Kidney renal clear cell carcinoma(64;0.00272)|STAD - Stomach adenocarcinoma(196;0.0134)|READ - Rectum adenocarcinoma(331;0.0655)|Lung(427;0.189)	L-Citrulline(DB00155)	TCGGAGAGCAAACACAGGGGTC	0.569													4	3	---	---	---	---					
LINC00969	440993	broad.mit.edu	37	3	195400639	195400641	+	RNA	DEL	GTG	GTG	-	rs145880653		TCGA-AK-3443-01A-01D-0966-08	TCGA-AK-3443-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3dc72bb8-02a6-41b1-a6d6-5c275a82f89b	e9f65a55-337b-4a82-a85a-b0f9a68f599d	g.chr3:195400639_195400641delGTG	ENST00000445430.1	+	0	1284																											AGGTGGGCTTGTGGAGGAATGGG	0.552													4	9	---	---	---	---					
HLA-DRB6	3128	broad.mit.edu	37	6	32521539	32521540	+	RNA	INS	-	-	GAAA	rs71843515		TCGA-AK-3443-01A-01D-0966-08	TCGA-AK-3443-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3dc72bb8-02a6-41b1-a6d6-5c275a82f89b	e9f65a55-337b-4a82-a85a-b0f9a68f599d	g.chr6:32521539_32521540insGAAA	ENST00000411500.1	-	0	851					NR_001298.1																						GGTCATTTGGGGAAAGACTTTA	0.431													4	2	---	---	---	---					
KIAA0408	9729	broad.mit.edu	37	6	127768325	127768329	+	Frame_Shift_Del	DEL	TTCTG	TTCTG	-			TCGA-AK-3443-01A-01D-0966-08	TCGA-AK-3443-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3dc72bb8-02a6-41b1-a6d6-5c275a82f89b	e9f65a55-337b-4a82-a85a-b0f9a68f599d	g.chr6:127768325_127768329delTTCTG	ENST00000483725.3	-	5	1471_1475	c.1135_1139delCAGAA	c.(1135-1140)afs	p.QK379fs	SOGA3_ENST00000481848.2_3'UTR|SOGA3_ENST00000556132.1_3'UTR	NM_014702.4	NP_055517.3	Q6ZU52	K0408_HUMAN	KIAA0408	379							protein binding			endometrium(3)|large_intestine(7)|lung(15)|ovary(1)|pancreas(1)|skin(1)	28				GBM - Glioblastoma multiforme(226;0.0217)|all cancers(137;0.13)		AGAGCAGGTTTTCTGAAACCACGAA	0.434													9	273	---	---	---	---					
TRGC2	6967	broad.mit.edu	37	7	38284914	38284917	+	RNA	DEL	CTGA	CTGA	-	rs147429736	by1000genomes	TCGA-AK-3443-01A-01D-0966-08	TCGA-AK-3443-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3dc72bb8-02a6-41b1-a6d6-5c275a82f89b	e9f65a55-337b-4a82-a85a-b0f9a68f599d	g.chr7:38284914_38284917delCTGA	ENST00000436911.2	-	0	330																											gtgtgtgtgtctgagtgtgtctgt	0.392													16	72	---	---	---	---					
STAG3L4	64940	broad.mit.edu	37	7	66767611	66767611	+	RNA	DEL	T	T	-	rs12531701	by1000genomes	TCGA-AK-3443-01A-01D-0966-08	TCGA-AK-3443-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3dc72bb8-02a6-41b1-a6d6-5c275a82f89b	e9f65a55-337b-4a82-a85a-b0f9a68f599d	g.chr7:66767611delT	ENST00000416602.2	+	0	4					NR_040586.1		Q8TBR4	STG34_HUMAN												endometrium(2)|lung(5)	7		Lung NSC(55;0.0839)|all_lung(88;0.181)				ACCGGACTGCTTTTTTTTTTT	0.542													3	5	---	---	---	---					
TNKS	8658	broad.mit.edu	37	8	9413576	9413577	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3443-01A-01D-0966-08	TCGA-AK-3443-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3dc72bb8-02a6-41b1-a6d6-5c275a82f89b	e9f65a55-337b-4a82-a85a-b0f9a68f599d	g.chr8:9413576_9413577insC	ENST00000310430.6	+	1	153_154	c.127_128insC	c.(127-129)cacfs	p.H43fs	RP11-375N15.2_ENST00000607598.1_RNA|TNKS_ENST00000520408.1_Frame_Shift_Ins_p.H43fs|TNKS_ENST00000522110.1_Frame_Shift_Ins_p.H43fs	NM_003747.2	NP_003738.2	O95271	TNKS1_HUMAN	tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase	43					mitotic spindle organization|mRNA transport|negative regulation of DNA binding|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of telomere maintenance via telomerase|protein auto-ADP-ribosylation|protein localization to chromosome, telomeric region|protein poly-ADP-ribosylation|protein polyubiquitination|protein transport|spindle assembly|transmembrane transport|Wnt receptor signaling pathway	chromosome, centromeric region|Golgi membrane|microsome|nuclear chromosome, telomeric region|nuclear membrane|nuclear pore|pericentriolar material	NAD+ ADP-ribosyltransferase activity|protein binding|zinc ion binding			NS(1)|endometrium(10)|kidney(6)|large_intestine(4)|lung(17)|ovary(2)|prostate(4)|skin(3)|upper_aerodigestive_tract(2)	49				COAD - Colon adenocarcinoma(149;0.0467)		GGCCCCGGGGACCACCCCAGCC	0.748													7	45	---	---	---	---					
RGS3	5998	broad.mit.edu	37	9	116356323	116356323	+	Frame_Shift_Del	DEL	T	T	-			TCGA-AK-3443-01A-01D-0966-08	TCGA-AK-3443-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3dc72bb8-02a6-41b1-a6d6-5c275a82f89b	e9f65a55-337b-4a82-a85a-b0f9a68f599d	g.chr9:116356323delT	ENST00000462403.1	+	1	558	c.124delT	c.(124-126)ttfs	p.F44fs	RGS3_ENST00000394646.3_Intron|RGS3_ENST00000342620.5_Intron|RGS3_ENST00000374140.2_Intron|RGS3_ENST00000343817.5_Intron|RGS3_ENST00000462143.1_Intron|RGS3_ENST00000350696.5_Intron|RGS3_ENST00000374134.3_Intron	NM_144489.2	NP_652760.2	P49796	RGS3_HUMAN	regulator of G-protein signaling 3	207					inactivation of MAPK activity|regulation of G-protein coupled receptor protein signaling pathway	cytosol|nucleus|plasma membrane	GTPase activator activity|signal transducer activity			cervix(1)|endometrium(3)|kidney(5)|large_intestine(11)|lung(22)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	48						CCAGAAGGAATTTTTTTTTCC	0.622													9	548	---	---	---	---					
MICALCL	84953	broad.mit.edu	37	11	12316384	12316389	+	In_Frame_Del	DEL	CTCCTA	CTCCTA	-	rs3812754	byFrequency	TCGA-AK-3443-01A-01D-0966-08	TCGA-AK-3443-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3dc72bb8-02a6-41b1-a6d6-5c275a82f89b	e9f65a55-337b-4a82-a85a-b0f9a68f599d	g.chr11:12316384_12316389delCTCCTA	ENST00000256186.2	+	3	1697_1702	c.1406_1411delCTCCTA	c.(1405-1413)cca>c	p.PPT469del		NM_032867.2	NP_116256.2	Q6ZW33	MICLK_HUMAN	MICAL C-terminal like	469	Poly-Pro.				cell differentiation|multicellular organismal development|spermatogenesis	cytoplasm	mitogen-activated protein kinase binding	p.T471delT(2)		breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(5)|lung(5)|ovary(3)|skin(3)|upper_aerodigestive_tract(1)	30				Epithelial(150;0.00177)		cctcctcctcctcctACAGCGGGAGG	0.573													8	23	---	---	---	---					
ROBO3	64221	broad.mit.edu	37	11	124750448	124750453	+	In_Frame_Del	DEL	CGGAGT	CGGAGT	-	rs55725290		TCGA-AK-3443-01A-01D-0966-08	TCGA-AK-3443-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3dc72bb8-02a6-41b1-a6d6-5c275a82f89b	e9f65a55-337b-4a82-a85a-b0f9a68f599d	g.chr11:124750448_124750453delCGGAGT	ENST00000397801.1	+	27	4285_4290	c.4093_4098delCGGAGT	c.(4093-4098)del	p.RS1367del	ROBO3_ENST00000538940.1_In_Frame_Del_p.RS1345del|ROBO3_ENST00000543966.1_In_Frame_Del_p.RS130del|ROBO3_ENST00000525482.1_3'UTR	NM_022370.3	NP_071765.2	Q96MS0	ROBO3_HUMAN	roundabout, axon guidance receptor, homolog 3 (Drosophila)	1367					axon midline choice point recognition	integral to membrane	receptor activity			breast(2)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(17)|ovary(1)|prostate(3)|upper_aerodigestive_tract(1)	35	all_hematologic(175;0.215)	Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|Breast(109;0.0481)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.5e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0296)		TGgccggagccggagtcggagtcaga	0.660													6	6	---	---	---	---					
C12orf43	64897	broad.mit.edu	37	12	121442108	121442109	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3443-01A-01D-0966-08	TCGA-AK-3443-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3dc72bb8-02a6-41b1-a6d6-5c275a82f89b	e9f65a55-337b-4a82-a85a-b0f9a68f599d	g.chr12:121442108_121442109insG	ENST00000445832.3	-	6	648_649	c.546_547insC	c.(544-549)ccccagfs	p.Q183fs	C12orf43_ENST00000536407.2_Intron|C12orf43_ENST00000539736.1_Frame_Shift_Ins_p.Q203fs|C12orf43_ENST00000537817.1_Frame_Shift_Ins_p.Q214fs|C12orf43_ENST00000288757.3_Frame_Shift_Ins_p.Q213fs|C12orf43_ENST00000366211.2_Frame_Shift_Ins_p.Q172fs			Q96C57	CL043_HUMAN	chromosome 12 open reading frame 43	213										cervix(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(10)	14	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)					GCCATGCTGGTGGGGGTGGTGG	0.550													8	313	---	---	---	---					
SLC24A1	9187	broad.mit.edu	37	15	65918177	65918179	+	In_Frame_Del	DEL	CTG	CTG	-			TCGA-AK-3443-01A-01D-0966-08	TCGA-AK-3443-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3dc72bb8-02a6-41b1-a6d6-5c275a82f89b	e9f65a55-337b-4a82-a85a-b0f9a68f599d	g.chr15:65918177_65918179delCTG	ENST00000261892.6	+	2	2046_2048	c.1759_1761delCTG	c.(1759-1761)del	p.L591del	SLC24A1_ENST00000399033.4_In_Frame_Del_p.L591del|SLC24A1_ENST00000544319.2_In_Frame_Del_p.L591del|SLC24A1_ENST00000339868.6_In_Frame_Del_p.L591del|SLC24A1_ENST00000537259.1_In_Frame_Del_p.L591del|SLC24A1_ENST00000546330.1_In_Frame_Del_p.L591del	NM_001254740.1|NM_004727.2	NP_001241669.1|NP_004718.1	O60721	NCKX1_HUMAN	solute carrier family 24 (sodium/potassium/calcium exchanger), member 1	591					response to light intensity|visual perception	integral to plasma membrane|membrane fraction|outer membrane	calcium, potassium:sodium antiporter activity|protein binding|symporter activity			breast(2)|endometrium(7)|kidney(1)|large_intestine(4)|lung(6)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	23						GTGGGAGAGCCTGCTGCTGCTGC	0.547													8	212	---	---	---	---					
IL32	9235	broad.mit.edu	37	16	3119304	3119305	+	Frame_Shift_Ins	INS	-	-	G	rs2981599		TCGA-AK-3443-01A-01D-0966-08	TCGA-AK-3443-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3dc72bb8-02a6-41b1-a6d6-5c275a82f89b	e9f65a55-337b-4a82-a85a-b0f9a68f599d	g.chr16:3119304_3119305insG	ENST00000525643.2	+	7	847_848	c.515_516insG	c.(514-516)gaafs	p.E172fs	IL32_ENST00000440815.3_Frame_Shift_Ins_p.E172fs|IL32_ENST00000526464.2_Frame_Shift_Ins_p.E172fs|IL32_ENST00000552936.1_Frame_Shift_Ins_p.E196fs|IL32_ENST00000529550.1_Frame_Shift_Ins_p.E172fs|IL32_ENST00000008180.9_Frame_Shift_Ins_p.E152fs|IL32_ENST00000552356.1_Frame_Shift_Ins_p.E152fs|IL32_ENST00000548652.1_Frame_Shift_Ins_p.E163fs|IL32_ENST00000548476.1_Frame_Shift_Ins_p.E218fs|IL32_ENST00000444393.3_Frame_Shift_Ins_p.E172fs|IL32_ENST00000551513.1_Frame_Shift_Ins_p.E209fs|IL32_ENST00000530538.2_Frame_Shift_Ins_p.E172fs|IL32_ENST00000534507.1_Frame_Shift_Ins_p.E218fs|IL32_ENST00000533097.2_Frame_Shift_Ins_p.E172fs|IL32_ENST00000531965.1_Frame_Shift_Ins_p.E162fs|IL32_ENST00000382213.3_Frame_Shift_Ins_p.E163fs|IL32_ENST00000552664.1_Frame_Shift_Ins_p.E172fs|IL32_ENST00000529699.1_Frame_Shift_Ins_p.E152fs|IL32_ENST00000528163.2_Frame_Shift_Ins_p.E172fs|IL32_ENST00000549213.1_Frame_Shift_Ins_p.E115fs|IL32_ENST00000551122.1_Frame_Shift_Ins_p.E115fs|IL32_ENST00000530890.1_Frame_Shift_Ins_p.E152fs|IL32_ENST00000396890.2_Frame_Shift_Ins_p.E218fs|IL32_ENST00000396887.3_Frame_Shift_Ins_p.E115fs|IL32_ENST00000548246.1_Frame_Shift_Ins_p.E132fs|IL32_ENST00000325568.5_Frame_Shift_Ins_p.E172fs			P24001	IL32_HUMAN	interleukin 32	218					cell adhesion|defense response|immune response	extracellular space	cytokine activity			breast(1)|endometrium(1)|large_intestine(3)|lung(6)|ovary(1)|pancreas(1)|skin(1)|urinary_tract(1)	15						CCACGGGGGGACAAGGAGGAGC	0.574													43	396	---	---	---	---					
NPIPB3	23117	broad.mit.edu	37	16	21415876	21415894	+	Frame_Shift_Del	DEL	GCGGCCCCCGCAGACGCTC	GCGGCCCCCGCAGACGCTC	-			TCGA-AK-3443-01A-01D-0966-08	TCGA-AK-3443-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3dc72bb8-02a6-41b1-a6d6-5c275a82f89b	e9f65a55-337b-4a82-a85a-b0f9a68f599d	g.chr16:21415876_21415894delGCGGCCCCCGCAGACGCTC	ENST00000458643.2	-	7	1365_1383	c.814_832delGAGCGTCTGCGGGGGCCGC	c.(814-834)ttfs	p.ERLRGPL272fs	NPIPB3_ENST00000448012.2_Frame_Shift_Del_p.PSVCGGR410fs|NPIPB3_ENST00000542817.1_Intron					nuclear pore complex interacting protein family, member B3																		GAGGGTGGAAGCGGCCCCCGCAGACGCTCGGCAGGTGTC	0.562													2	4	---	---	---	---					
CDC27	996	broad.mit.edu	37	17	45219612	45219612	+	Frame_Shift_Del	DEL	A	A	-			TCGA-AK-3443-01A-01D-0966-08	TCGA-AK-3443-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3dc72bb8-02a6-41b1-a6d6-5c275a82f89b	e9f65a55-337b-4a82-a85a-b0f9a68f599d	g.chr17:45219612delA	ENST00000066544.3	-	11	1454	c.1361delT	c.(1360-1362)cafs	p.L454fs	CDC27_ENST00000446365.2_Frame_Shift_Del_p.L393fs|CDC27_ENST00000531206.1_Frame_Shift_Del_p.L460fs|CDC27_ENST00000527547.1_Frame_Shift_Del_p.L454fs	NM_001114091.1|NM_001256.3	NP_001107563.1|NP_001247.3	P30260	CDC27_HUMAN	cell division cycle 27	454					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell proliferation|mitotic cell cycle spindle assembly checkpoint|mitotic metaphase/anaphase transition|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination	anaphase-promoting complex|centrosome|cytosol|nucleoplasm|spindle microtubule	protein phosphatase binding			NS(1)|breast(5)|central_nervous_system(3)|cervix(1)|endometrium(2)|kidney(17)|large_intestine(18)|lung(11)|ovary(5)|pancreas(1)|prostate(19)|skin(5)|upper_aerodigestive_tract(2)	90						TGCTTTTTGTAGATTAAAGGC	0.308													8	86	---	---	---	---					
MICAL3	57553	broad.mit.edu	37	22	18301237	18301238	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3443-01A-01D-0966-08	TCGA-AK-3443-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3dc72bb8-02a6-41b1-a6d6-5c275a82f89b	e9f65a55-337b-4a82-a85a-b0f9a68f599d	g.chr22:18301237_18301238insC	ENST00000441493.2	-	26	4541_4542	c.4189_4190insG	c.(4189-4191)gccfs	p.A1397fs		NM_015241.2	NP_056056.2	Q7RTP6	MICA3_HUMAN	microtubule associated monooxygenase, calponin and LIM domain containing 3	1397	Pro-rich.					cytoplasm|cytoskeleton	monooxygenase activity|zinc ion binding			large_intestine(1)|lung(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	4		all_epithelial(15;0.198)		Lung(27;0.0427)		GGACAACGGCTCGCCTTCCGGC	0.644													11	339	---	---	---	---					
KANTR	102723508	broad.mit.edu	37	X	53142508	53142509	+	RNA	INS	-	-	A	rs145002653	by1000genomes	TCGA-AK-3443-01A-01D-0966-08	TCGA-AK-3443-10A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3dc72bb8-02a6-41b1-a6d6-5c275a82f89b	e9f65a55-337b-4a82-a85a-b0f9a68f599d	g.chrX:53142508_53142509insA	ENST00000604849.1	+	0	96																											AACACACACACAAAAAAAAACC	0.356													6	5	---	---	---	---